WorldWideScience

Sample records for cell research problems

  1. Embryonic stem cell research: an ethical problem

    OpenAIRE

    Рамазанова, А.

    2014-01-01

    Embryonic stem cells offer hope for new therapies, but their use and research entail an ethical problem, which does not have a certain solution. Therefore, we can ask: What exactly are the ethical arguments? Why are they so tricky to resolve?Embryonic stem cell research poses a moral dilemma. It forces us to choose between two moral principles: The duty to prevent or alleviate suffering The duty to respect the value of human life To obtain embryonic stem cells, the early embryo has to be dest...

  2. State of the art: Multi-fuel reformers for automotive fuel cell applications. Problem identification and research needs

    Energy Technology Data Exchange (ETDEWEB)

    Westerholm, R. [Stockholm Univ. (Sweden). Dept. of Analytical Chemistry; Pettersson, L.J. [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Chemical Engineering and Technology

    1999-12-01

    On an assignment from the Transport and Communications Research Board (KFB) a literature study and a study trip to the USA and Great Britain have been performed. The literature study and the study trip was made during late spring and autumn 1999.The purpose of the project was to collect available information about the chemical composition of the product gas from a multi-fuel reformer for a fuel cell vehicle. It was furthermore to identify problems and research needs. The report recommends directions for future major research efforts. The results of the literature study and the study trip led to the following general conclusions: With the technology available today it does not seem feasible to develop a highly efficient and reliable multi-fuel reformer for automotive applications, i. e. for applications where all types of fuels ranging from natural gas to heavy diesel fuels can be used. The potential for developing a durable and reliable system is considerably higher if dedicated fuel reformers are used.The authors propose that petroleum-derived fuels should be designed for potential use in mobile fuel cell applications. In the present literature survey and the site visit discussions we found that there are relatively low emissions from fuel cell engines compared to internal combustion engines. However, the major research work on reformers/fuel cells have been performed during steady-state operation. Emissions during start-up, shutdown and transient operation are basically unknown and must be investigated in more detail. The conclusions and findings in this report are based on open/available information, such as discussions at site visits, reports, scientific publications and symposium proceedings.

  3. Fuel cells problems and solutions

    CERN Document Server

    Bagotsky, Vladimir S

    2012-01-01

    The comprehensive, accessible introduction to fuel cells, their applications, and the challenges they pose Fuel cells-electrochemical energy devices that produce electricity and heat-present a significant opportunity for cleaner, easier, and more practical energy. However, the excitement over fuel cells within the research community has led to such rapid innovation and development that it can be difficult for those not intimately familiar with the science involved to figure out exactly how this new technology can be used. Fuel Cells: Problems and Solutions, Second Edition addresses this i

  4. caBIG® Spotlight - Solving Research Problems: Analyze Mouse Embryonic Stem Cell Transcriptional Profiles —

    Science.gov (United States)

    Read a case study to learn more about how Dr. Bradley Merrill of the University of Illinois at Chicago and his lab were able to perform their first gene expression array experiment comparing a mutant mouse embryonic stem cell line to a non-mutant control line using GenePattern, an application supported by the Molecular Analysis Tools Knowledge Center which provides bioinformatics tools for gene expression, proteomic and SNP analysis.

  5. No Problem? No Research, Little Learning ... Big Problem!

    Directory of Open Access Journals (Sweden)

    Fernando Ornelas Marques

    2012-06-01

    Full Text Available The motivation to carry out this study stemmed from the generalized perception that nowadays youth lacks the skills for the 21st century. Especially the high-level competences like critical thinking, problem solving and autonomy. Several tools can help to improve these competences (e.g. the SCRATCH programming language, but, as researchers and educators, we are mostly concerned with the skill to recognize problems. What if we do not find problems to solve? What if we do not even feel the need to find or solve problems? The problem is to recognize the problem; the next step is to equate the problem; finally we have to feel the need to solve it. No need? No invention. Recognizing a problem is probably the biggest problem of everyday life, because we are permanently faced with problems (many ill-defined problems, which we need to identify, equate and solve.

  6. No Problem? No Research, Little Learning ... Big Problem!

    Directory of Open Access Journals (Sweden)

    Fernando Ornelas Marques

    2012-06-01

    Full Text Available The motivation to carry out this study stemmed from the generalized perception that nowadays youth lacks the skills for the 21st century. Especially the high-level competences like critical thinking, problem solving and autonomy. Several tools can help to improve these competences (e.g. the SCRATCH programming language, but, as researchers and educators, we are mostly concerned with the skill to recognize problems. What if we do not find problems to solve? What if we do not even feel the need to find or solve problems? The problem is to recognize the problem; the next step is to equate the problem; finally we have to feel the need to solve it. No need? No invention. Recognizing a problem is probably the biggest problem of everyday life, because we are permanently faced with problems (many ill-defined problems, which we need to identify, equate and solve.

  7. CELL RESEARCH

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    REVIEWSInducible resistance to Fas-mediated apoptosis in B cells…………………………………ROTHSTEIN Thomas L (245)Executionary pathway for apoptosis: lessons from mutant mice………………………………………WOO Minna, Razqallah Hakem, Tak W Mak (267)The SHP-2 tyrosine phosphatase: Signaling mechanisms and biological functions…………………………………QU Cheng Kui (279)REGULAR ARTICLESTemperature dependent expression of cdc2 and cyclin B1 in spermatogenic cells during spermatogenesis…………………………KONG Wei Hua, Zheng GU, Jining LU, Jiake TSO (289)Transgenic mice overexpressing γ-aminobutyric acid transporter subtype I develop obesity…………………………………MA Ying Hua, Jia Hua HU, Xiao Gang ZHOU, Ruo Wang ZENG, Zhen Tong MEI, Jian FEI, Li He GUO (303)Genetic aberration in primary hepatocellular carcinoma: correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and 9p21-p23………………………………………WANG Gang, Chang Hui HUANG, Yan ZHAO, Ling CAI, Ying WANG, Shi Jin XIU, Zheng Wen JIANG, Shuang YANG, Xin Tai ZHAO, Wei HUANG, Jian Ren GU (311)Identification and genetic mapping of four novel genes that regulate leaf deve- lopment in Arabidopsis………………………………………………SUN Yue, Wei ZHANG, Feng Ling LI, Ying Li GUO, Tian Lei LIU, Hai HUANG (325)NOTICE FOR CONTRIBUTORS…………………………………(337)CONTENTS of Vol. 10, 2000…………………………………………………(338)

  8. Methodological problems in Rorschach research

    Directory of Open Access Journals (Sweden)

    Đurić-Jočić Dragana

    2007-01-01

    Full Text Available Comprehensive System of Rorschach interpretation is considered as nomotetic system that makes possible using of projective method in research projects. However, research use of Rorschach method besides of appropriate knowledge of assign procedures and interpretation rules, means a knowledge of specific methodological issues. The Rorschach indicators are nor independent, as they are a part of specific net, so in some research it is necessary to control basic variables not to get artifacts in our research. This is basically relied on researches where we compare groups, as well as in normative studies where through cross-cultural we compare Rorschach indicators. .

  9. Engaged Problem Formulation in IS Research

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby

    2016-01-01

    problems requires a more substantial engagement with the different stakeholders, especially when their problems are ill structured and situated in complex organizational settings. On this basis, we present an engaged approach to formulating IS problems with, not for, IS practitioners. We have come......“Is this the problem?”: the question that haunts many information systems (IS) researchers when they pursue work relevant to both practice and research. Nevertheless, a deliberate answer to this question requires more than simply asking the involved IS practitioners. Deliberately formulating...... to understand engaged problem formulation as joint researching and as the defining of contemporary and complex problems by researchers and those practitioners who experience and know these problems. We used this approach in investigating IS management in Danish municipalities. In this paper, we present...

  10. RESEARCH ON NONLINEAR PROBLEMS IN STRUCTURAL DYNAMICS.

    Science.gov (United States)

    Research on nonlinear problems structural dynamics is briefly summarized. Panel flutter was investigated to make a critical comparison between theory...panel flutter in aerospace vehicles, plausible simplifying assumptions are examined in the light of experimental results. Structural dynamics research

  11. Engaged Problem Formulation in IS Research

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby

    2016-01-01

    “Is this the problem?”: the question that haunts many information systems (IS) researchers when they pursue work relevant to both practice and research. Nevertheless, a deliberate answer to this question requires more than simply asking the involved IS practitioners. Deliberately formulating...... to understand engaged problem formulation as joint researching and as the defining of contemporary and complex problems by researchers and those practitioners who experience and know these problems. We used this approach in investigating IS management in Danish municipalities. In this paper, we present...... the approach to formulating problems in an engaged way. We discuss it in relation to ideas and assumptions that underpin engaged scholarship, and we discuss the implications for IS action research, design science research, and mixed approaches....

  12. Fuel Cell Research

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Peter M. [Brown University

    2014-03-30

    Executive Summary In conjunction with the Brown Energy Initiative, research Projects selected for the fuel cell research grant were selected on the following criteria: They should be fundamental research that has the potential to significantly impact the nation’s energy infrastructure. They should be scientifically exciting and sound. They should synthesize new materials, lead to greater insights, explore new phenomena, or design new devices or processes that are of relevance to solving the energy problems. They involve top-caliper senior scientists with a record of accomplishment, or junior faculty with outstanding promise of achievement. They should promise to yield at least preliminary results within the given funding period, which would warrant further research development. They should fit into the overall mission of the Brown Energy Initiative, and the investigators should contribute as partners to an intellectually stimulating environment focused on energy science. Based on these criteria, fourteen faculty across three disciplines (Chemistry, Physics and Engineering) and the Charles Stark Draper Laboratory were selected to participate in this effort.1 In total, there were 30 people supported, at some level, on these projects. This report highlights the findings and research outcomes of the participating researchers.

  13. Problem-Oriented Researches in Literary Studies

    Directory of Open Access Journals (Sweden)

    Dr. A. Razi

    2012-01-01

    Full Text Available Being familiar with research methodology causes an increase in the effectivity and efficiency in research. One of the most valuable subjects in research methodology is to discuss about principles and skill of "Problem-oriented" researches that seems to be less known in literary studies.Propagation of problem-oriented researches in the field of Persian language and literature needs serious considerations to its principles and regulations, changing the viewpoint of literary researches, reconsideration in the curriculum of higher education centers, and finally revision in methods and procedure of doing a research plan in this field.Emphasing the necessity of the further consideration of problem-oriented in literary studies, in this article the characteristics and features of this type of research is discussed. Also the methods and skills of problem-finding in the field of literature are described and types of literary problem are introduced. Moreover the different steps that must be followed by a researcher in order to solve the literary problems are stated.

  14. Operations research problems statements and solutions

    CERN Document Server

    Poler, Raúl; Díaz-Madroñero, Manuel

    2014-01-01

    The objective of this book is to provide a valuable compendium of problems as a reference for undergraduate and graduate students, faculty, researchers and practitioners of operations research and management science. These problems can serve as a basis for the development or study of assignments and exams. Also, they can be useful as a guide for the first stage of the model formulation, i.e. the definition of a problem. The book is divided into 11 chapters that address the following topics: Linear programming, integer programming, non linear programming, network modeling, inventory theory, queue theory, tree decision, game theory, dynamic programming and markov processes. Readers are going to find a considerable number of statements of operations research applications for management decision-making. The solutions of these problems are provided in a concise way although all topics start with a more developed resolution. The proposed problems are based on the research experience of the authors in real-world com...

  15. Research mathematicians’ practices in selecting mathematical problems

    DEFF Research Database (Denmark)

    Misfeldt, Morten; Johansen, Mikkel Willum

    2015-01-01

    Developing abilities to create, inquire into, qualify, and choose among mathematical problems is an important educational goal. In this paper, we elucidate how mathematicians work with mathematical problems in order to understand this mathematical process. More specifically, we investigate how...... mathematicians select and pose problems and discuss to what extent our results can be used to inform, criticize, and develop educational practice at various levels. Selecting and posing problems is far from simple. In fact, it is considered hard, complex, and of crucial importance. A number of criteria...... and suggest that mathematics education research could further investigate how students select and develop problems, work with multiple problems over a longer period of time, and use the solutions to problems to support the development of new problems. Furthermore, the negative emotional aspects of being stuck...

  16. [Reprogramming of somatic cells. Problems and solutions].

    Science.gov (United States)

    Schneider, T A; Fishman, V S; Liskovykh, M A; Ponamartsev, S V; Serov, O L; Tomilin, A N; Alenina, N

    2014-01-01

    An adult mammal is composed of more than 200 different types of specialized somatic cells whose differentiated state remains stable over the life of the organism. For a long time it was believed that the differentiation process is irreversible, and the transition between the two types of specialized cells is impossible. The possibility of direct conversion of one differentiated cell type to another was first shown in the 80s of the last century in experiments on the conversion of fibroblasts into myoblasts by ectopic expression of the transcription factor MyoD. Surprisingly, this technology has remained unclaimed in cell biology for a long time. Interest in it revived after 200 thanks to the research of Novel Prize winner Shinya Yamanaka who has shown that a small set of transcription factors (Oct4, Sox2, Klf4 and c-Myc) is capable of restoring pluripotency in somatic cells which they lost in the process of differentiation. In 2010, using a similar strategy and the tissue-specific transcription factors Vierbuchen and coauthors showed the possibility of direct conversion of fibroblasts into neurons, i. e. the possibility of transdifferentiation of one type of somatic cells in the other. The works of these authoras were a breakthrough in the field of cell biology and gave a powerful impulse to the development of cell technologies for the needs of regenerative medicine. The present review discusses the main historical discoveries that preceded this work, evaluates the status of the problem and the progress in the development of methods for reprogramming at the moment, describes the main approaches to solving the problems of reprogramming of somatic cells into neuronal, and briefly discusses the prospect of application of reprogramming and transdifferentiation of cells for such important application areas as regenerative medicine, cell replacement therapy and drug screening.

  17. Pondering over Several Problems in Disaster Research

    Institute of Scientific and Technical Information of China (English)

    SHAN Xiuzheng

    2001-01-01

    Some related problems in disaster research are presented. The paper concludes that catastrophology is an extremely important natural-social science, that human calamities are even more destructive than natural disasters and that research on disasters such as highway traffic accidents, nuclear wars, population expansion, environment pollution and the like are of important practical meaning and far-reaching historic significance.

  18. Engaged Problem Formulation in IS Research

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby

    2016-01-01

    “Is this the problem?”: the question that haunts many information systems (IS) researchers when they pursue work relevant to both practice and research. Nevertheless, a deliberate answer to this question requires more than simply asking the involved IS practitioners. Deliberately formulating...

  19. Actual problems of research in food science.

    Science.gov (United States)

    Schmandke, H

    1981-01-01

    Starting from the necessary trend towards development in the field of food production, the author outlines, on the basis of current knowledge, the problems to be solved in food science. A general research conception is deduced for the essential nutrient "protein" (as an example) which is illustrated by results from studies on protein fibre and protein gel formation.

  20. Some Problems in International Comparative Research.

    Science.gov (United States)

    Halloran, James D.

    1995-01-01

    Examines some problems and difficulties encountered in international comparative research programs in mass communications: comparability of units of analysis; lack of consensus manifested in dichotomization into "conventional" and "critical" approaches; and suitability of exported models, theories, concepts, and methods to Third World conditions.…

  1. Landmine research: technology solutions looking for problems

    Science.gov (United States)

    Trevelyan, James P.

    2004-09-01

    The global landmine problem came to the attention of researchers in the mid 1990's and by 1997 several advanced and expensive sensor research programs had started. Yet, by the end of 2003, there is little sign of a major advance in the technology available to humanitarian demining programs. Given the motivation and dedication of researchers, public goodwill to support such programs, and substantial research resources devoted to the problem, it is worth asking why these programs do not seem to have had an impact on demining costs or casualty rates. Perhaps there are factors that have been overlooked. This paper reviews several research programs to gain a deeper understanding of the problem. A possible explanation is that researchers have accepted mistaken ideas on the nature of the landmine problems that need to be solved. The paper provides several examples where the realities of minefield conditions are quite different to what researchers have been led to believe. Another explanation may lie in the political and economic realities that drive the worldwide effort to eliminate landmines. Most of the resources devoted to landmine clearance programs come from humanitarian aid budgets: landmine affected countries often contribute only a small proportion because they have different priorities based on realistic risk-based assessment of needs and political views of local people. Some aid projects have been driven by the need to find a market for demining technologies rather than by user needs. Finally, there is a common misperception that costs in less developed countries are intrinsically low, reflecting low rates paid for almost all classes of skilled labour. When actual productivity is taken into account, real costs can be higher than industrialized countries. The costs of implementing technological solutions (even using simple technologies) are often significantly under-estimated. Some political decisions may have discouraged thorough investigation of cost

  2. Advanced Research Workshop on Nonlinear Hyperbolic Problems

    CERN Document Server

    Serre, Denis; Raviart, Pierre-Arnaud

    1987-01-01

    The field of nonlinear hyperbolic problems has been expanding very fast over the past few years, and has applications - actual and potential - in aerodynamics, multifluid flows, combustion, detonics amongst other. The difficulties that arise in application are of theoretical as well as numerical nature. In fact, the papers in this volume of proceedings deal to a greater extent with theoretical problems emerging in the resolution of nonlinear hyperbolic systems than with numerical methods. The volume provides an excellent up-to-date review of the current research trends in this area.

  3. The fencing problem and Coleochaete cell division.

    Science.gov (United States)

    Wang, Yuandi; Dou, Mingya; Zhou, Zhigang

    2015-03-01

    The findings in this study suggest that the solution of a boundary value problem for differential equation system can be used to discuss the fencing problem in mathematics and Coleochaete, a green algae, cell division. This differential equation model in parametric expression is used to simulate the two kinds of cell division process, one is for the usual case and the case with a "dead" daughter cell.

  4. Dye solar cell research

    CSIR Research Space (South Africa)

    Cummings, F

    2009-11-01

    Full Text Available stream_source_info Cummings_2009.pdf.txt stream_content_type text/plain stream_size 3362 Content-Encoding UTF-8 stream_name Cummings_2009.pdf.txt Content-Type text/plain; charset=UTF-8 DYE SOLAR CELL RESEARCH Franscious... Cummings Energy and Processes Materials Science and Manufacturing Council for Scientific and Industrial Research P.O. Box 395 Pretoria 0001, South Africa 27 November 2009 CONTENT head2rightBackground head2rightCSIR Dye Solar Cell Research head2...

  5. Longitudinal research strategies: advantages, problems, and prospects.

    Science.gov (United States)

    Farrington, D P

    1991-05-01

    The single-cohort, long-term longitudinal survey has many advantages in comparison with a cross-sectional survey in advancing knowledge about offending and other types of psychopathology, notably in providing information about onset and desistance, about continuity and prediction, and about within-individual change. However, the longitudinal survey also has significant problems, notably in confounding aging and period effects, delayed results, achieving continuity in funding and research direction, and cumulative attrition. This paper suggests the use of a multiple-cohort sequential strategy (the "accelerated longitudinal design") as a way of achieving the benefits of the longitudinal method while minimizing the problems in advancing knowledge about the natural history, causes, prevention, and treatment of psychopathological disorders.

  6. 柔性Job Shop类型机器人制造单元调度研究%Research on Flexible Job Shop Scheduling Problem of Robotic Manufacturing Cell

    Institute of Scientific and Technical Information of China (English)

    张沙清; 杨海东; 赵洁

    2015-01-01

    Flexible Job Shop scheduling problem of robotic manufacturing cell is a new kind of scheduling problem with wide engineering application background and tough challenges,which attracts much attention of academia and industry. The content and features of flexible Job Shop scheduling problem of robotic manufacturing cell were analyzed,a scheduling model based on molds manufacturing with the op-timizing targets to minimal makespan was proposed in this paper. A Chaotic Quantum-behaved Particle Swarm Optimization algorithm (CQPSO) was put forward to solve the model. Based on the Quantum-behaved Particle Swarm Optimization (QPSO),the improved Tend chaotic mapping mechanism was introduced. The shortcoming of easily falling into local minimum for QPSO could be avoided, meanwhile,the fast convergence speed of QPSO could be kept in this algorithm. So the effectiveness of algorithm was improved. The sim-ulation results show that CQPSO could effectively solved the flexible Job Shop scheduling problem of robotic manufacturing cell.%柔性Job Shop类型机器人制造单元调度问题是一类新的具有广泛工程应用背景而又极富挑战的调度问题,引起了学术界和工业界的极大关注。文中分析了柔性Job Shop类型机器人单元调度问题的内容与特点,并以模具生产为背景,构建了一种以工件组最大完工时间最小为目标的Job Shop类型机器人单元调度模型,进而提出了一种混沌量子粒子群算法( CQPSO)用于模型求解。该算法在量子粒子群算法( QPSO)基础上,引入改进的Tent混沌映射机制,在保持QPSO算法收敛速度快的同时,克服了其易陷入局部极小值的缺点,提高了算法求解效率。仿真实验结果表明,CQPSO算法在求解柔性Job Shop类型机器人调度问题方面具有较大的应用优势。

  7. Engaged Problem Formulation in IS Research

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby

    2016-01-01

    problems requires a more substantial engagement with the different stakeholders, especially when their problems are ill structured and situated in complex organizational settings. On this basis, we present an engaged approach to formulating IS problems with, not for, IS practitioners. We have come...

  8. Advances in stem cell research

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@In 1998, biologists Thomson and Gearhart successfully derived stem cells from human embryos. One year later, several researchers discovered that adult stem cells still retain the ability to be differentiated into unrelated types of cells. Advances in stem cell research open a promising direction for applied medical science. Moreover, it may also force scientists to reconsider the fundamental theory about how cells grow up. Stem cell research was considered by Science as the top of the ten breakthroughs of science of the year[1]. This paper gives a survey of recent advances in stem cell research. 1 Overview In the 1980s, embryonic stem cell and/or embryonic germ cell line (ES cell line, EG cell line) of multifarious mammalian animals, especially those of non-human pri-mates, had been established. In 1998, Thomson and Shamblott obtained ES, EG cell lines from human blasto-cysts and gonad ridges of early human embryos, respec-tively. Their research brought up an ethical debate about whether human embryos can be used as experimental materials. It was not appeased until 1999 when research-ers discovered that stem cells from adults still retain the ability to become different kinds of tissue cells. For in-stance, brain cells can become blood cells[2], and cells from bone marrow can become cells in liver. Scientists believe, for a long time, that cells can only be developed from early pluripotent embryo cells; the differentiation potential of stem cells from mature tissues is restricted to only one of the cell types of the tissue where stem cells are obtained. Recent stem cell researches, however, sub-verted the traditional view of stem cells. These discoveries made scientists speed ahead with the work on adult stem cells, hoping to discover whether their promise will rival that of ES cells.

  9. Researching wicked problems in a construction project

    DEFF Research Database (Denmark)

    Jacobsen, Peter Holm

    to empirical research. I will argue that uncertainty is an important aspect of doing empirical research because the empirical research is a part of a situated learning process and that uncertain situations are a central part of conducting empirical research. I will use an example from my study of the early...

  10. Information on Stem Cell Research

    Science.gov (United States)

    ... Home » Current Research » Focus on Research Focus on Stem Cell Research Stem cells possess the unique ability to differentiate into many ... they also retain the ability to produce more stem cells, a process termed self-renewal. There are multiple ...

  11. The Factors Affecting Definition of Research Problems in Educational Technology Researches

    Science.gov (United States)

    Bahçekapili, Ekrem; Bahçekapili, Tugba; Fis Erümit, Semra; Göktas, Yüksel; Sözbilir, Mustafa

    2013-01-01

    Research problems in a scientific research are formed after a certain process. This process starts with defining a research topic and transforms into a specific research problem or hypothesis. The aim of this study was to examine the way educational technology researchers identify their research problems. To this end, sources that educational…

  12. Internet Marketing Research: Opportunities and Problems

    NARCIS (Netherlands)

    Furrer, O.F.G.; Sudharshan, D.

    2001-01-01

    The Internet is promised a brilliant future among the favorite tools of marketing researchers. Develops a typology of Internet marketing surveys showing the existence of eight different designs that can be used by marketers. However, researchers who plan to develop research using the Internet need t

  13. THE PROBLEM FIELD OF NEOSHAMANISM CULTURE RESEARCH

    Directory of Open Access Journals (Sweden)

    Ms. Yanina A. Yelinskaya

    2016-09-01

    Full Text Available The article is aimed at considering the problems of cultural studies of neoshamanism and at defining the specificity of this phenomenon. The problem of the content and scope of the concept of «neoshamanism» is focused on; the basic types of neoshamanism are defined. The issues of religious nature of neoshamanism, shamanic ecstasy and the shamanic universe representation are analyzed in the article. The issues of neoshamanism functioning within the framework of contemporary culture and interaction with external cultural institutions are raised.

  14. Problem Complexity Research from Energy Perspective

    CERN Document Server

    Feng, Pan; Jie, Qi

    2013-01-01

    Computational complexity is a particularly important objective. The idea of Landauer principle was extended through mapping three classic problems (sorting,ordered searching and max of N unordered numbers) into Maxwell demon thought experiment in this paper. The problems'complexity is defined on the entropy basis and the minimum energy required to solve them are rigorous deduced from the perspective of energy (entropy) and the second law of thermodynamics. Then the theoretical energy consumed by real program and basic operators of classical computer are both analyzed, the time complexity lower bounds of three problems'all possible algorithms are derived in this way. The lower bound is also deduced for the two n*n matrix multiplication problem. In the end, the reason why reversible computation is impossible and the possibility of super-linear energy consumption capacity which may be the power behind quantum computation are discussed, a conjecture is proposed which may prove NP!=P. The study will bring fresh an...

  15. Chinese Family Problems: Research and Trends.

    Science.gov (United States)

    Zhangling, Wei

    1983-01-01

    Discusses family life in China, which has undergone several dramatic changes including raising of the legal marriage age, less restrictions on divorce, and official promotion of family planning. Because these policies and practices conflict with Chinese traditions, inevitable problems have arisen. (JAC)

  16. Technology, relationships, and problems: a research synthesis.

    Science.gov (United States)

    Hertlein, Katherine M; Webster, Megan

    2008-10-01

    The advances in technology alter the ways we interact with each other. For some, the use of technology can facilitate a relationship; for others, technology can complicate aspects of a relationship. The purpose of this research synthesis is to summarize current research exploring the ways in which technology impacts relationships negatively. Eight studies were reviewed across the following areas: preoperational definitions, sample, methodology, control of extraneous variables, causal influence, generalizability, validity of statistical findings, and conclusions. Implications for authors, researchers, and therapists working with couples and families struggling with technology issues are discussed.

  17. Vaal River catchment: problems and research needs

    CSIR Research Space (South Africa)

    Braune, E

    1987-01-01

    Full Text Available disappearance of chlorinated pesticides from the environment. Such surveys should be followed up in potential problem tributaries with intensive agricultural activity like the Harts River. Conservation and recreation Conservation Demands on the Vaal system... Spitskop Dam. 3.2.4 Rainfall stimulation The potential for rainfall and runoff enhancement through weather modification is being intensively investigated by the Weather Bureau of the Department of Environment Affairs in cooperation with the Department...

  18. RESEARCH Problems related to cytomegalovirus infection and ...

    African Journals Online (AJOL)

    RESEARCH. 890 November ... include an embryonic form (BA splenic malformation (BASM)) ... We performed a retrospective review of hospital records of patients with ... Ethical approval of the study was granted (S12/02/061) by the ethics.

  19. Organic Solar Cells: Problems and Perspectives

    Directory of Open Access Journals (Sweden)

    G. Chidichimo

    2010-01-01

    Full Text Available For photovoltaic cells to convert solar into electric energy is probably the most interesting research challenge nowadays. A good efficiency of these devices has been obtained by using inorganic semiconductor materials. On the other hand, manufacture processes are very expensive in terms of both materials and techniques. For this reason organic-based photovoltaic (OPV cells are attracting the general attention because of the possible realization of more economical devices. Organic materials are abundant and easily handling. Unfortunately OPV cells efficiency is significantly lower than that of inorganic-based devices, representing a big point of weakness at the present. This is mainly due to the fact that organic semiconductors have a much higher band gap with respect to inorganic semiconductors. In addition, OPV cells are very susceptible to oxygen and water. In this paper we will describe some of the different approaches to the understanding and improving of organic photovoltaic devices.

  20. Computational problems in magnetic fusion research

    Energy Technology Data Exchange (ETDEWEB)

    Killeen, J.

    1981-08-31

    Numerical calculations have had an important role in fusion research since its beginning, but the application of computers to plasma physics has advanced rapidly in the last few years. One reason for this is the increasing sophistication of the mathematical models of plasma behavior, and another is the increased speed and memory of the computers which made it reasonable to consider numerical simulation of fusion devices. The behavior of a plasma is simulated by a variety of numerical models. Some models used for short times give detailed knowledge of the plasma on a microscopic scale, while other models used for much longer times compute macroscopic properties of the plasma dynamics. The computer models used in fusion research are surveyed. One of the most active areas of research is in time-dependent, three-dimensional, resistive magnetohydrodynamic models. These codes are reviewed briefly.

  1. Academic Freedom: Problems in Conceptualization and Research

    Science.gov (United States)

    Abdel Latif, Muhammad M. M.

    2014-01-01

    Academic freedom is of central importance to higher education and it affects all aspects of work at universities. It symbolizes academics' acceptance of the need for openness and flexibility (Balyer, 2011) and it protects the conditions leading to the creation of good teaching and learning, sound research, and scholarship (Atkinson, 2004).…

  2. Problems Portraying Migrants in Applied Linguistics Research

    Science.gov (United States)

    Block, David

    2010-01-01

    This paper is a very personal attempt to explore the problematics of portraying migrants in Applied Linguistics research. I begin with a discussion of identity, in particular what we might mean when we use the term, and from there I go on to explore its fundamental imprecision through an analysis of a census question about ethnicity. I then…

  3. Problem Solving: Polya's Heuristic Applied to Psychological Research.

    Science.gov (United States)

    Damarin, Suzanne K.

    Using the "How to Solve It" list developed by Polya as a vehicle of comparison, research findings and key concepts from the psychological study of problem solving are applied to mathematical problem solving. Hypotheses concerning the interpretation of psychological phenomena for mathematical problem situations are explored. Several areas…

  4. ADDRESSING RESEARCH DESIGN PROBLEM IN MIXED METHODS RESEARCH

    OpenAIRE

    Hamed ALAVI; Patrycja HĄBEK

    2016-01-01

    Alongside other disciplines in social sciences, management researchers use mixed methods research more and more in conduct of their scientific investigations. Mixed methods approach can also be used in the field of production engineering. In comparison with traditional quantitative and qualitative research methods, reasons behind increasing popularity of mixed research method in management science can be traced in different factors. First of all, any particular discipline in management can be...

  5. ADDRESSING RESEARCH DESIGN PROBLEM IN MIXED METHODS RESEARCH

    Directory of Open Access Journals (Sweden)

    Hamed ALAVI

    2016-01-01

    Full Text Available Alongside other disciplines in social sciences, management researchers use mixed methods research more and more in conduct of their scientific investigations. Mixed methods approach can also be used in the field of production engineering. In comparison with traditional quantitative and qualitative research methods, reasons behind increasing popularity of mixed research method in management science can be traced in different factors. First of all, any particular discipline in management can be theoretically related to it. Second is that concurrent approach of mixed research method to inductive and deductive research logic provides researchers with opportunity to generate theory and test hypothesis in one study simultaneously. In addition, it provides a better justification for chosen method of investigation and higher validity for obtained answers to research questions. Despite increasing popularity of mixed research methods among management scholars, there is still need for a comprehensive approach to research design typology and process in mixed research method from the perspective of management science. The authors in this paper try to explain fundamental principles of mixed research method, its typology and different steps in its design process.

  6. Immobilized Cell Research

    Science.gov (United States)

    1990-10-31

    beads, the plasmid is twice as stable as in cells In a process where immobilized cells produce material grown in continuous culture over 200...carrageenan) or chemically cross-linked, or- Penicillium chrysogenum than in washed freely suspended ganic polymer (Ca-alginate, polyacrylamide, and mycelium ...these materials are formed into the freely suspended cells stopped after 6 days. If the beads of several millimeters in diameter by allowing the

  7. Problems of information support in scientific research

    Science.gov (United States)

    Shamaev, V. G.; Gorshkov, A. B.

    2015-11-01

    This paper reports on the creation of the open access Akustika portal (AKDATA.RU) designed to provide Russian-language easy-to-read and search information on acoustics and related topics. The absence of a Russian-language publication in foreign databases means that it is effectively lost for much of the scientific community. The portal has three interrelated sections: the Akustika information search system (ISS) (Acoustics), full-text archive of the Akusticheskii Zhurnal (Acoustic Journal), and 'Signal'naya informatsiya' ('Signaling information') on acoustics. The paper presents a description of the Akustika ISS, including its structure, content, interface, and information search capabilities for basic and applied research in diverse areas of science, engineering, biology, medicine, etc. The intended users of the portal are physicists, engineers, and engineering technologists interested in expanding their research activities and seeking to increase their knowledge base. Those studying current trends in the Russian-language contribution to international science may also find the portal useful.

  8. Sexual problems in gay men: an overview of empirical research.

    Science.gov (United States)

    Sandfort, T G; de Keizer, M

    2001-01-01

    This article summarizes the findings and theoretical perspectives of 19 empirical studies of sexual problems in gay men. In order to understand these problems better, various differences between male homosexual and heterosexual functioning are discussed first. The studies included differ widely in terms of the issues explored, the populations studied, and the way data have been collected. In a few studies, researchers generally have looked at the prevalence and experience of sexual problems. In other studies, researchers have focused on the etiology and treatment of specific problems, such as sexual desire disorders, sexual aversion, excitement and arousal problems, orgasm disorders, sexual pain disorders and sexual compulsivity. Overall it is surprising how little is known about these problems in gay men. This is also true, however, for same-sex sexuality in general. Suggestions are made for studies that will enable us to obtain a better understanding of sexual problems in gay men.

  9. Cell Science and Cell Biology Research at MSFC: Summary

    Science.gov (United States)

    2003-01-01

    The common theme of these research programs is that they investigate regulation of gene expression in cells, and ultimately gene expression is controlled by the macromolecular interactions between regulatory proteins and DNA. The NASA Critical Path Roadmap identifies Muscle Alterations and Atrophy and Radiation Effects as Very Serious Risks and Severe Risks, respectively, in long term space flights. The specific problem addressed by Dr. Young's research ("Skeletal Muscle Atrophy and Muscle Cell Signaling") is that skeletal muscle loss in space cannot be prevented by vigorous exercise. Aerobic skeletal muscles (i.e., red muscles) undergo the most extensive atrophy during long-term space flight. Of the many different potential avenues for preventing muscle atrophy, Dr. Young has chosen to study the beta-adrenergic receptor (betaAR) pathway. The reason for this choice is that a family of compounds called betaAR agonists will preferentially cause an increase in muscle mass of aerobic muscles (i.e., red muscle) in animals, potentially providing a specific pharmacological solution to muscle loss in microgravity. In addition, muscle atrophy is a widespread medical problem in neuromuscular diseases, spinal cord injury, lack of exercise, aging, and any disease requiring prolonged bedridden status. Skeletal muscle cells in cell culture are utilized as a model system to study this problem. Dr. Richmond's research ("Radiation & Cancer Biology of Mammary Cells in Culture") is directed toward developing a laboratory model for use in risk assessment of cancer caused by space radiation. This research is unique because a human model will be developed utilizing human mammary cells that are highly susceptible to tumor development. This approach is preferential over using animal cells because of problems in comparing radiation-induced cancers between humans and animals.

  10. Cell Science and Cell Biology Research at MSFC: Summary

    Science.gov (United States)

    2003-01-01

    The common theme of these research programs is that they investigate regulation of gene expression in cells, and ultimately gene expression is controlled by the macromolecular interactions between regulatory proteins and DNA. The NASA Critical Path Roadmap identifies Muscle Alterations and Atrophy and Radiation Effects as Very Serious Risks and Severe Risks, respectively, in long term space flights. The specific problem addressed by Dr. Young's research ("Skeletal Muscle Atrophy and Muscle Cell Signaling") is that skeletal muscle loss in space cannot be prevented by vigorous exercise. Aerobic skeletal muscles (i.e., red muscles) undergo the most extensive atrophy during long-term space flight. Of the many different potential avenues for preventing muscle atrophy, Dr. Young has chosen to study the beta-adrenergic receptor (betaAR) pathway. The reason for this choice is that a family of compounds called betaAR agonists will preferentially cause an increase in muscle mass of aerobic muscles (i.e., red muscle) in animals, potentially providing a specific pharmacological solution to muscle loss in microgravity. In addition, muscle atrophy is a widespread medical problem in neuromuscular diseases, spinal cord injury, lack of exercise, aging, and any disease requiring prolonged bedridden status. Skeletal muscle cells in cell culture are utilized as a model system to study this problem. Dr. Richmond's research ("Radiation & Cancer Biology of Mammary Cells in Culture") is directed toward developing a laboratory model for use in risk assessment of cancer caused by space radiation. This research is unique because a human model will be developed utilizing human mammary cells that are highly susceptible to tumor development. This approach is preferential over using animal cells because of problems in comparing radiation-induced cancers between humans and animals.

  11. Problems of Translation in Cross-Cultural Research

    Science.gov (United States)

    Sechrest, Lee; And Others

    1972-01-01

    Various types of translation problems in cross-cultural research are translation of questions or other verbal stimuli, vocabulary equivalence, equivalence in idiom, grammar, syntax, and back-translation. (Author/SB)

  12. Esperanto and International Language Problems: A Research Bibliography.

    Science.gov (United States)

    Tonkin, Humphrey R.

    This bibliography is intended both for the researcher and for the occasional student of international language problems, particularly as these relate to the international language Esperanto. The book is divided into two main sections: Part One deals with problems arising from communication across national boundaries and the search for a solution…

  13. Transdisciplinary weed research: new leverage on challenging weed problems?

    NARCIS (Netherlands)

    Jordan, N.; Schut, M.; Graham, S.; Barney, J.N.; Childs, D.Z.; Christensen, S.B.; Cousens, R.D.; Davis, A.S.; Eizenberg, H.; Ervin, D.E.; Fernandez-Quintanilla, C.; Harrison, L.J.; Harsch, M.A.; Heijting, S.; Liebman, M.; Loddo, D.; Mirsky, S.B.; Riemens, M.; Neve, P.; Peltzer, D.A.; Renton, M.; Williams, M.; Recasens, J.; Sønderskov, M.

    2016-01-01

    Transdisciplinary weed research (TWR) is a promising path to more effective management of challenging weed problems. We define TWR as an integrated process of inquiry and action that addresses complex weed problems in the context of broader efforts to improve economic, environmental and social

  14. Transdisciplinary weed research: new leverage on challenging weed problems?

    Science.gov (United States)

    Transdisciplinary Weed Research (TWR) is a promising path to more effective management of challenging weed problems. We define TWR as an integrated process of inquiry and action that addresses complex weed problems in the context of broader efforts to improve economic, environmental and social aspec...

  15. Cognitive variables in science problem solving: a review of research

    OpenAIRE

    Solaz Portolés, Joan Josep; Vicente SANJOSÉ LÓPEZ

    2007-01-01

    This paper provides an overview of research into cognitive variables that are involved in problem solving and how these variables affect the performance of problem solvers. The variables discussed are grouped together in: prior knowledge, formal reasoning ability and neo-Piagetian variables, long-term memory and working memory, knowledge base, and metacognitive variables.

  16. A Methodological Problem Associated with Researching Women Entrepreneurs

    OpenAIRE

    Beatrice E. Avolio

    2011-01-01

    This article highlights one of the most significant methodological problems of researching women entrepreneurs and understanding the female entrepreneurial experience, which is related to the definition of what is a women entrepreneur. The article outlines the state of research on women entrepreneurs, presents the diverse definitions used in research, conceptualizes the different aspects related to the definition of a woman entrepreneur, and proposes future directions for developing research ...

  17. [Stem cells, stem cell therapy, and ethical problems of medicine].

    Science.gov (United States)

    Hruska, I; Filip, S

    2007-01-01

    Common denominator of many philosophic approaches to the problem of using human embryos in medicine is the statement that it is "a full-value human subject that deserves respect as an adult human being". It has a defined identity in which it starts its own coordinated gradual development. Therefore, it is not just a simple cluster of cells. Integrity or holistic properties of a new quality of cells that, as a whole, represent an early embryo, and in fact are not a cluster of pre-embryonic "structural" parts or a sum of cells etc. They have theirs own evolution, previously inherently encoded, but not precisely predestined. In other words, only autointegrity alone in evolution, inherence as a part of predetermination in evolution of embryo, is not able to exist as a unit "alone". Human foetus since the first moments of its existence goes through many qualitative (externally or internally determined) transformations before it becomes a respectable human being. It is possible to say that medicine, as many times before, is now coming to a stage when axiologic values, ethical directives or moral feelings of its subjects and human objects proved in the past, are no more relevant at present. Therefore, medicine has no other alternative than an active approach to study this problem from all philosophical, biological and medical aspects to evolutionize itself in this new dimension. In this paper some of these questions are discussed and some ways of forming the ethics in therapeutic use of stem cells are presented.

  18. Bioprinting for stem cell research.

    Science.gov (United States)

    Tasoglu, Savas; Demirci, Utkan

    2013-01-01

    Recently, there has been growing interest in applying bioprinting techniques to stem cell research. Several bioprinting methods have been developed utilizing acoustics, piezoelectricity, and lasers to deposit living cells onto receiving substrates. Using these technologies, spatially defined gradients of immobilized biomolecules can be engineered to direct stem cell differentiation into multiple subpopulations of different lineages. Stem cells can also be patterned in a high-throughput manner onto flexible implementation patches for tissue regeneration or onto substrates with the goal of accessing encapsulated stem cells of interest for genomic analysis. Here, we review recent achievements with bioprinting technologies in stem cell research, and identify future challenges and potential applications including tissue engineering and regenerative medicine, wound healing, and genomics.

  19. Researching Historical Problems. An Introduction to Basic Resources.

    Science.gov (United States)

    Freeman, Michael Stuart

    The Dartmouth College Library has produced this slide/tape individualized instruction module to assist students in researching historical problems. The 79-slide lesson begins with methods of organizing a search and continues through collecting information and analyzing the utility of research strategy. Information sources cited include numerous…

  20. The Research State and Problems Needing Study of Green Maintenance

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    According with the request of sustainable development for asset maintenance, in this paper the research state of China and other countries are indexed, then the contents of green maintenance were described and a system model of green maintenance was established. This paper discussed in brief the problems needing research, key techniques and adoptable methods of green maintenance.``

  1. A facility for using cluster research to study environmental problems

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This report begins by describing the general application of cluster based research to environmental chemistry and the development of a Cluster Structure and Dynamics Research Facility (CSDRF). Next, four important areas of cluster research are described in more detail, including how they can impact environmental problems. These are: surface-supported clusters, water and contaminant interactions, time-resolved dynamic studies in clusters, and cluster structures and reactions. These facilities and equipment required for each area of research are then presented. The appendices contain workshop agenda and a listing of the researchers who participated in the workshop discussions that led to this report.

  2. [Problems in medicinal materials research of new traditional Chinese medicine].

    Science.gov (United States)

    Zhou, Gang; Wang, Ting; He, Yan-Ping

    2014-08-01

    Medicinal materials research and development of new drug of traditional Chinese medicine (TCM) research is the premise and foundation of new drug research and development, it throughout the whole process of new drug research. Medicinal materials research is one of the main content of the pharmaceutical research of new drug of TCM, and it is also the focus of the new medicine pharmaceutical evaluation content. This article through the analysis of the present problems existing in the development of TCM research of new drug of TCM, from medicine research concept, quality stability, quality standard, etc are expounded, including medicine research idea value medicine study should focus on the important role and from the purpose for the top-level design of new drug research problem. Medicinal materials quality stability should pay attention to the original, medicinal part, origin, processing, storage, planting (breeding), and other aspects. Aspect of quality standard of medicinal materials should pay attention to establish the quality standards of conform to the characteristics of new drug of TCM. As the instruction of TCM new drug research and development and the scientific nature of the review, and provide the basis for medicinal material standards.

  3. Researching consumers' attitudes: Some difficulties, problems and dilemmas

    Directory of Open Access Journals (Sweden)

    Gutić Dragutin

    2010-01-01

    Full Text Available Consumers' attitudes have always had a central place in marketing theory and practice. There is a great number of different problems, difficulties and dilemmas, which come from different sources and have different content, and which very often arise as a stumbling block in researching consumers' attitudes. Part of them is already contained in different views on term attitudes itself. The second part lies in an unsolved puzzle of consumers' attitudes and behaviour relation. The third part is of methodological nature in research. The fourth is in usage of different, numerous techniques that researchers have at their disposal when researching attitudes. It might sound unbelievable, but since the 1960s till today, very few researchers have understood, and knew real nature of the term, essence and meaning of attitudes in marketing. There is even less of them who know how to examine attitudes and generally use adequately and productively. Attitudes belong to the most complex psychical processes. The complexity of attitudes is manifesting during the research. It is not a rarity to become convinced that important contents, such as: determining dimensions, components, sources of emerging and stability of researched attitudes are not present in attitudes' examination and research. In most cases, research results of consumers' attitudes are actually nothing more than statements about the existence of positive and negative attitudes. There is still no complex method that can be used in research. Different, essentially partial methods are being used instead, usually to investigate particular components and dimensions of consumers' attitudes. There are more groups of problems that appear in consumers' attitudes examination. For this occasion, we point out three: problems that result from lack of knowledge and not adequate understanding of attitudes; problems related to level of examinee's (consumer's consciousness of his attitude; problems emerging from

  4. Research assessment in the humanities: problems and challenges

    OpenAIRE

    Galimberti Paola,

    2010-01-01

    Research assessment is going to play a new role in the governance of universities and research institutions. Evaluation of results is evolving from a simple tool for resource allocation towards policy design. In this respect "measuring" implies a different approach to quantitative aspects as well as to an estimation of qualitative criteria that are difficult to define. Bibliometrics became so popular, in spite of its limits, just offering a simple solution to complex problems. The theory behi...

  5. Enabling Effective Problem-oriented Research for Sustainable Development

    Directory of Open Access Journals (Sweden)

    Michael Stauffacher

    2012-12-01

    Full Text Available Environmental problems caused by human activities are increasing; biodiversity is disappearing at an unprecedented rate, soils are being irreversibly damaged, freshwater is increasingly in short supply, and the climate is changing. To reverse or even to reduce these trends will require a radical transformation in the relationship between humans and the natural environment. Just how this can be achieved within, at most, a few decades is unknown, but it is clear that academia must play a crucial role. Many believe, however, that academic institutions need to become more effective in helping societies move toward sustainability. We first synthesize current thinking about this crisis of research effectiveness. We argue that those involved in producing knowledge to solve societal problems face three particular challenges: the complexity of real-world sustainability problems, maintaining impartiality when expert knowledge is used in decision making, and ensuring the salience of the scientific knowledge for decision makers. We discuss three strategies to meet these challenges: conducting research in interdisciplinary teams, forming research partnerships with actors and experts from outside academia, and framing research questions with the aim of solving specific problems (problem orientation. However, we argue that implementing these strategies within academia will require both cultural and institutional change. We then use concepts from transition management to suggest how academic institutions can make the necessary changes. At the level of system optimization, we call for: quality criteria, career incentives, and funding schemes that reward not only disciplinary excellence but also achievements in inter-/transdisciplinary work; professional services and training through specialized centers that facilitate problem-oriented research and reciprocal knowledge exchange with society; and the integration of sustainability and inter

  6. Data, Problems, Heuristics and Results in Cognitive Metaphor Research

    Science.gov (United States)

    Kertesz, Andras; Rakosi, Csilla; Csatar, Peter

    2012-01-01

    Cognitive metaphor research is characterized by the diversity of rival theories. Starting from this observation, the paper focuses on the problem of how the unity and diversity of cognitive theories of metaphor can be accounted for. The first part of the paper outlines a suitable metascientific approach which emerges as a modification of B. von…

  7. Spatial extent in demographic research - approach and problems

    Directory of Open Access Journals (Sweden)

    Knežević Aleksandar

    2015-01-01

    Full Text Available One of the starting methodological problems in demographic research is the definition of spatial extent, which mostly doesn’t correspond to spatial extent already defined by different levels of administrative-territorial unitsthat are used for distribution of usable statistical data. That’s why determining the spatial extent of a demographic research is closely tied with administrative-territorial division of the territory that is being researched, wherein the fact that differentiation of demographic phenomena and processes cannot be the only basis of setting the principles of regionalization must be strictly acknowledged. This problem is particularly common in historical demographic analyses of geographically determined wholes, which are in administratively-territorial sense represented by one or more smaller territorial units, with their borders changing through the history, which directly affects comparability of the statistical data, and makes it considerably more difficult to track demographic change through longer time intervals. The result of these efforts is usually a solution based on a compromise which enables us to examine the dynamics of population change with little deviation from already defined borders of regional geographic wholes. For that reason in this paper the problem of defining spatial extent in demographic research is examined trough several different approaches in case of Eastern Serbia, as a geographically determined region, a historic area, a spatially functioning whole and as a statistical unit for demographic research, with no judgment calls in regard to any of the regionalization principles. [Projekat Ministarstva nauke Republike Srbije, br. III 47006

  8. [The research of the idea of population problems (author's transl)].

    Science.gov (United States)

    Shinozaki, N

    1982-07-01

    Approximately 200 years have passed since Malthus pointed out various population problems. Since then, many scholars have discussed and researched the population principles attributable to Malthus. Formal demography has developed recently. However, the conception of population problems has been discussed more on an a priori level rather than on a philosophical level. We cannot conceive of man himself without introspection about what is man. This problem has also been approached by other philosophers--Plato, Aristotle, Kant, Feuerbach, Marx, Neitzche, Scheler, Heidegger, Dilthey, Pascal, Northrop, Sartre, Buber, Landmann, and others. It is possible to classify views of the human being into about 20 patterns. Until now, there have been different ideas among population researchers and students in Japan. Some have thought of population as the abstract mass of man; others thought of it as a concrete mass of man. Further inquiry into this idea would allow the author to proceed to examine man himself, population, and population problems from a philosopher's point of view. A new theory of population problems could then be established by improving the population principles of Malthus. (author's modified)

  9. A problem with inclusion in learning disability research.

    Science.gov (United States)

    McClimens, Alex; Allmark, Peter

    2011-09-01

    People with severe learning disability are particularly difficult to include in the research process. As a result, researchers may be tempted to focus on those with learning disability who can be included. The problem is exacerbated in this field as the political agenda of inclusion and involvement is driven by those people with learning disability who are the higher functioning. To overcome this we should first detach the notion of consent from ideas about autonomy and think instead of it as a way to avoid wronging others; this fits the original historical use of consent in research. This allows us to think in terms of including participants to the best of their abilities rather than in terms of a threshold of autonomy. Researchers could then use imaginative ways to include the least able and to ensure they are not wronged in research or by exclusion from it.

  10. International Society for Stem Cell Research

    Science.gov (United States)

    ... and regenerative medicine community in the world. More stem cell research Take a closer look Recent Blogs View ... story independent nonprofit organization & the voice of the stem cell research community The International Society for Stem Cell ...

  11. Artificial intelligence and design: Opportunities, research problems and directions

    Science.gov (United States)

    Amarel, Saul

    1990-01-01

    The issues of industrial productivity and economic competitiveness are of major significance in the U.S. at present. By advancing the science of design, and by creating a broad computer-based methodology for automating the design of artifacts and of industrial processes, we can attain dramatic improvements in productivity. It is our thesis that developments in computer science, especially in Artificial Intelligence (AI) and in related areas of advanced computing, provide us with a unique opportunity to push beyond the present level of computer aided automation technology and to attain substantial advances in the understanding and mechanization of design processes. To attain these goals, we need to build on top of the present state of AI, and to accelerate research and development in areas that are especially relevant to design problems of realistic complexity. We propose an approach to the special challenges in this area, which combines 'core work' in AI with the development of systems for handling significant design tasks. We discuss the general nature of design problems, the scientific issues involved in studying them with the help of AI approaches, and the methodological/technical issues that one must face in developing AI systems for handling advanced design tasks. Looking at basic work in AI from the perspective of design automation, we identify a number of research problems that need special attention. These include finding solution methods for handling multiple interacting goals, formation problems, problem decompositions, and redesign problems; choosing representations for design problems with emphasis on the concept of a design record; and developing approaches for the acquisition and structuring of domain knowledge with emphasis on finding useful approximations to domain theories. Progress in handling these research problems will have major impact both on our understanding of design processes and their automation, and also on several fundamental questions

  12. Artificial intelligence and design: Opportunities, research problems and directions

    Science.gov (United States)

    Amarel, Saul

    1990-01-01

    The issues of industrial productivity and economic competitiveness are of major significance in the U.S. at present. By advancing the science of design, and by creating a broad computer-based methodology for automating the design of artifacts and of industrial processes, we can attain dramatic improvements in productivity. It is our thesis that developments in computer science, especially in Artificial Intelligence (AI) and in related areas of advanced computing, provide us with a unique opportunity to push beyond the present level of computer aided automation technology and to attain substantial advances in the understanding and mechanization of design processes. To attain these goals, we need to build on top of the present state of AI, and to accelerate research and development in areas that are especially relevant to design problems of realistic complexity. We propose an approach to the special challenges in this area, which combines 'core work' in AI with the development of systems for handling significant design tasks. We discuss the general nature of design problems, the scientific issues involved in studying them with the help of AI approaches, and the methodological/technical issues that one must face in developing AI systems for handling advanced design tasks. Looking at basic work in AI from the perspective of design automation, we identify a number of research problems that need special attention. These include finding solution methods for handling multiple interacting goals, formation problems, problem decompositions, and redesign problems; choosing representations for design problems with emphasis on the concept of a design record; and developing approaches for the acquisition and structuring of domain knowledge with emphasis on finding useful approximations to domain theories. Progress in handling these research problems will have major impact both on our understanding of design processes and their automation, and also on several fundamental questions

  13. Recent developments in blood cell labeling research

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, S.C.; Straub, R.F.; Meinken, G.E.

    1988-09-07

    A number of recent developments in research on blood cell labeling techniques are presented. The discussion relates to three specific areas: (1) a new in vitro method for red blood cell labeling with /sup 99m/Tc; (2) a method for labeling leukocytes and platelets with /sup 99m/Tc; and (3) the use of monoclonal antibody technique for platelet labeling. The advantages and the pitfalls of these techniques are examined in the light of available mechanistic information. Problems that remain to be resolved are reviewed. An assessment is made of the progress as well as prospects in blood cell labeling methodology including that using the monoclonal antibody approach. 37 refs., 4 figs.

  14. Conference Essay: Tackling Problems of Qualitative Social Research: A Conversation

    Directory of Open Access Journals (Sweden)

    Paul Sebastian Ruppel

    2008-01-01

    Full Text Available This paper comprises discussions from a residential symposium, "Methods in Dialogue", that took place near Cambridge, UK, in May 2005. The symposium concluded a series of seminars organised by the London East Research Institute and the Centre for Narrative Research at the University of East London and supported by the Economic and Social Research Council. Public support for social research increasingly depends on its ability to deliver scientifically valid and reliable studies to guide policy and practice. The theoretical foundations of social research, however, seem to be in a critical state. Evidence generated by both qualitative and quantitative methods is more and more seen to be conflicting, open to many interpretations. The aim of the event was to bring together qualitative researchers in the social sciences, many working in the field of narrative but also a number working with life history and auto/biography, discourse analysis, grounded theory methodology, visual methods and ethnography, to discuss the theoretical foundations of qualitative social research. The discussions addressed narrative itself as an index case for methodological debate; methodological considerations of objectivity and evidence, interpretation and context; appropriate levels of research focus and their interactions; the role of dialogue between disciplines; and the interaction between social science and the wider environment of which it is a part. Questions such as the following were discussed throughout the symposium: Who and what is social research for, and whose voices does it represent? What are social researchers' and participants' interpretative rights over their data and each other? How does thick description and the rich social interpretation it affords relate to the need for precise methods of explanation and generalisable conclusions? What special problems of research design or delivery arise when attempts are made to "empower" informants, to enable them

  15. Water Security Problem in North China: Research and Perspective

    Institute of Scientific and Technical Information of China (English)

    XIA Jun; LIU Meng-Yu; JIA Shao-Feng

    2005-01-01

    This paper addresses the emergence of water security problems in North China with the aim of highlighting key water resources management and water security issues for the long-term development of North China. Three key problems related to water resources and security issues in North China in the 21st century are addressed, namely 1) the water cycle under environmental change, 2) agricultural water saving, and 3) water security. Development of international research related to these issues is also reviewed. The research plan developed recently by the Chinese Academy of Sciences (CAS) is discussed and suggestions on research and development of water resources science in North China are presented.Thanks to focus on experimental catchments and dedicated research stations, a detailed knowledge of the water cycle on North China farmland has been compiled. A range of techniques that include isotope tracers has been used to acquire hydrologic data. Much research has been devoted to developing distributed hydrological models at different scales. In the well irrigation district, five different water saving irrigation regimes have been investigated, and these regimes have had widespread application, and reduced water use 60-150 mm while they increased water use efficiency (WUE) by 20%-30%.Furthermore, preventing water pollution is the most essential step to ensure North China's water security.

  16. Research on hydraulic-powered roof supports test problems

    Institute of Scientific and Technical Information of China (English)

    SUN Hong-bo; JIANG Jin-qiu; MA Qiang

    2011-01-01

    The load-bearing characters of hydraulic-powered roof support with dual telescopic legs were analyzed. With a specific type hydraulic-powered roof support with dual telescopic legs for research object, the inside load test problems in factories was analyzed, and the correct test methods were given, which can enhance the test efficiency and make the factories away from the error design of hydraulic-powered roof supports and legs.

  17. Current challenges in dedifferentiated fat cells research.

    Science.gov (United States)

    Shah, Mickey; George, Richard L; Evancho-Chapman, M Michelle; Zhang, Ge

    2016-07-02

    Dedifferentiated fat cells show great promises as a novel cell source for stem cell research. It has many advantages when used for cell-based therapeutics including abundance, pluripotency, and safety. However, there are many obstacles researchers need to overcome to make the next big move in DFAT cells research. In this review, we summarize the current main challenges in DFAT cells research including cell culture purity, phenotypic properties, and dedifferentiation mechanisms. The common methods to produce DFAT cells as well as the cell purity issue during DFAT cell production have been introduced. Current approaches to improve DFAT cell purity have been discussed. The phenotypic profile of DFAT cells have been listed and compared with other stem cells. Further studies on elucidating the underlying dedifferentiation mechanisms will dramatically advance DFAT cell research.

  18. University bioscientists' risk epistemologies and research problem choices

    Science.gov (United States)

    Appuhamilage Dilshani Eranga Sarathchandra, Walakada

    Scientific discoveries take place within scientific communities that are established in legitimating organizations such as universities and research institutes. Often times, scientists undergo tensions and paradoxes as they evaluate the risks they are willing to accept in their work. The types of risk/benefit decisions scientists make to determine which research projects to engage in and how they engage in them is more important than ever, due to current restrictions on funding for scientific research. The main objective of this dissertation is to analyze the ways in which university bioscientists define, evaluate, and manage risks in science, i.e. their risk epistemologies. In the process, I examine bioscientists' risk perceptions and demographic and contextual factors that influence those perceptions. Additionally, I investigate the associations between risk perceptions and research problem choices. This dissertation followed a mix-methods approach. The data collection included twenty semi-structured in-depth interviews and a large-scale online survey of university bioscientists. Based on three theoretically driven research questions that surfaced through examining current literature, I organized the dissertation into three different essays. The first essay explores risk epistemologies of university bioscientists as they determine the best trajectories for their scientific careers. This essay analyses data gathered by conducting in-depth interviews meant to elicit university bioscientists' different understandings of the notion of risk. The second essay quantifies bioscientists' risk perceptions using data gathered from the online survey. In this essay, I investigate the influence of life-course, gender, sources of funding, research orientation, network interactions, and perceived significance of research on risk perception. In the third essay I use data gathered from the online survey to investigate the associations between university bioscientists' risk

  19. CREATIVE CORE WITHIN THE SCIENTIFIC RESEARCH OF EDUCATIONAL PROBLEMS

    Directory of Open Access Journals (Sweden)

    Vladimir I. Zagvyazinsky

    2014-01-01

    Full Text Available Abstract. The authors continue to explore the issue of practical methodology of research studies (Education and Science No 8, 2014. The aim of the study is to reveal theoretical and practical issues of empirical-research activity at the stages of conceptual problem understanding of pedagogical research, ideas promotion, development of the conception of their practical implementation and formation of scientifically grounded constructive hypotheses. Methods. The applied methods include theoretical analysis, synthesis, abstraction, idealization, generalization, specification, comparison, classification, extrapolation, modelling and hermeneutic interpretation. Results. Scientifically grounded description of the process of creative research of educational problems is presented in the paper. The content of such notions as «concept», «creative core», «idea», «plot», and «research hypothesis» is revealed. The creative core of scientific research is considered in close relation to the key aspects of the scientific inquiry: problematics definition, research topic and subject selection, clarification of initial facts and theoretical statements, definition of the conceptual framework, determination of essential novelty. The authors explore the mechanisms of the scientific research through the analysis of the educational situation and initial facts to the formation of a conceptual framework of research and the further working out of its instrumental component. The creative core of research is characterised as its most difficult element including the inception of idea transformation, its realisation into some conception and expansion into productive hypothesis. The authors describe the types of hypotheses, such as working and scientific (ready, functional and explanatory. The logical and gnoseological structure of a scientific hypothesis is shown in the study. The methodological requirements to the formulation of the scientific hypotheses are

  20. [Stem cell research and science and technology policy in Japan].

    Science.gov (United States)

    Yashiro, Yoshimi

    2011-12-01

    In this paper I review the present condition of the regeneration medicine research using pluripotency and a somatic stem cell, and I describe the subject of the science and technology policy in Japan towards realization of regeneration medicine. The Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) supported research promotion by the prompt action in 2007 when establishment of the iPS cell was reported by Shinya Yamanaka. Although the hospitable support of the Japanese government to an iPS cell is continued still now, there are some problems in respect of the support to other stem cell researches, and industrialization of regeneration medicine. In order to win a place in highly competitive area of investigation, MEXT needs to change policy so that funds may be widely supplied also to stem cell researches other than iPS cell research.

  1. [Reference standards in diagnostic research: problems and solutions].

    Science.gov (United States)

    de Groot, Joris A H; Reitsma, Johannes B; Moons, Karel G M

    2014-01-01

    The accuracy of diagnostic tests is of utmost importance as biased test results may lead to wrong decisions in clinical practice. In diagnostic accuracy research the results of a diagnostic test, model or strategy are compared to those of the reference standard, i.e. the best available method to determine whether a certain condition or disease is present or absent. Problems with the reference standard lead to biased test results. The umbrella term for this is 'verification bias'. Verification bias arises if the reference standard cannot be applied to all patients, if investigators use different reference standards or simply because there is no reference standard. Correction of these problems is often possible, and, if it is applied in a transparent and reproducible fashion it will deliver useful diagnostic information. Clinicians who use a diagnostic test should take possible verification bias into account.

  2. Theory Building in Qualitative Research: Reconsidering the Problem of Induction

    Directory of Open Access Journals (Sweden)

    Pedro F. Bendassolli

    2013-01-01

    Full Text Available The problem of induction refers to the difficulties involved in the process of justifying experience-based scientific conclusions. More specifically, inductive reasoning assumes a leap from singular observational statements to general theoretical statements. It calls into question the role of empirical evidence in the theory-building process. In the philosophy of science, the validity of inductive reasoning has been severely questioned since at least the writings of David HUME. At the same time, induction has been lauded as one of the main pillars of qualitative research methods, and its identity as such has consolidated to the detriment of hypothetical-deductive methods. This article proposes reviving discussion on the problem of induction in qualitative research. It is argued that qualitative methods inherit many of the tensions intrinsic to inductive reasoning, such as those between the demands of empiricism and of formal scientific explanation, suggesting the need to reconsider the role of theory in qualitative research. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1301258

  3. Problem-centric Process for Research-based Learning

    Directory of Open Access Journals (Sweden)

    Khaled Shaban

    2015-05-01

    Full Text Available Research-based Learning (RbL extends Inquiry and Project-based Learning by facilitating an early stage exposure and training for future scientists through authentic research activities. In this paper, an iterative problem-centric RbL process is introduced, and its activities and management aspects are described. The process helps implement course-integrated research systematically and practically. Furthermore, the novel process follows constructivist methods in incorporating inquiry, scaffolding, open-ended projects, as well as a goal oriented learning approach. The RbL process is adopted in two advanced computing courses, at two different universities: a leading comprehensive Western university and a new university in a developing country. The paper summarizes new lessons learned in these rewarding experiences. In particular, the instructor should help students start their projects, by providing them with previous work or data and pre-approving the papers to review by students. He should also maintain a continuous feedback to and from students to keep the students motivated and help the instructor refine and adapt the RBL process. We note that research collaborators can help students in identifying the research topics early. The paper also shows how to alleviate difficulties that may be encountered by students who find the novel approach demanding, and consequently it also helps the instructors better manage the course contents.

  4. Trends and problems in marital and family therapy research: Possible use of action research

    Directory of Open Access Journals (Sweden)

    Robert Cvetek

    2006-03-01

    Full Text Available Although research in marital and family therapy (MFT is becoming increasingly important, it continues to encounter several major problems. Studies have shown that research has very little influence on the practice of the majority of MFT practitioners. Practitioners see research as unrelated to their concerns. The practice of the majority of MFT practitioners is very individualized, as are the clinical problems and circumstances. Some have therefore started to emphasize the transferability of results instead of generalizability, and studying the practitioner's own practice instead of general concepts. Action research in the field of psychotherapy, as well as in the field of MFT, has been mainly overlooked as a potential method for solving these problems in MFT research. The paper addresses one of many possible ways to use the repeating cycles of the four basic steps in action research (observing and gathering information, reflecting, planning, and acting. The use of these four steps in action research enables therapists to study and improve their own practice in a more systematic, structured, and valid manner. This kind of research connects research and therapy. It is very individualized and oriented towards actions that create therapeutic changes.

  5. THE CONSTRUCTION OF THE RESEARCH PROBLEM AND ITS DISCUSSION

    Directory of Open Access Journals (Sweden)

    Eva Pasek de Pinto

    2008-04-01

    Full Text Available Language has different functions. One of them, the communication, is fundamental for the investigation, because the textualization of its process and results is the base of the diffusion of the advance and increase of the scientific knowledge. However, most students - and those who are not already so - present difficulties in using references, in breaks in cohesion, or in logical and argumentative coherence. Such difficulties limit the generation of texts, as they constitute an obstacle to translate written ideas into an argumentative discourse, typical of science and research. The latter requires the argued presentation of an idea, whose perception, description and obvious reasons make up the problem that is wanted to know, to explain, to verify, to understand or to interpret. Therefore, this short space / time has the purpose of reflecting on the discursive construction of the problem of an inquiry. Its importance lies precisely in the disadvantages of its configuration. In this sense, the reflection is developed from a vision of language and communication; The argumentative discourse and the types of reasoning involved in order to fulfill certain guidelines that underlie the construction of the problem of inquiry and its approach in terms of a positivist-quantitative and / or qualitative study.

  6. Translation of clinical problems in osteoarthritis into pathophysiological research goals.

    Science.gov (United States)

    van der Kraan, Peter M; Berenbaum, Francis; Blanco, Francisco J; Cosimo, de Bari; Lafeber, Floris; Hauge, Ellen; Higginbottom, Adele; Ioan-Facsinay, Andreea; Loughlin, John; Meulenbelt, Ingrid; Moilanen, Eeva; Pitsillidou, Irene; Tsezou, Aspasia; van Meurs, Joyce; Vincent, Tonia; Wittoek, Ruth; Lories, Rik

    2016-01-01

    Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent has a strongly ageing population and an obesity epidemic; obesity and age both being major risk factors for OA. No adequate therapeutic options, besides joint replacement, are available, although they are greatly needed and should be acquired by adequate research investments. However, the perspective on OA from a researcher's point of view is not always aligned with the perspective of a patient with OA. Researchers base their views on OA mainly on abnormalities in structure and function while patients consider OA as a collection of symptoms. In this viewpoint paper, we discuss the possibility of translating the most important clinical problems into pathophysiological research goals to facilitate the translation from bench to bedside and vice versa. This viewpoint is the outcome of a dialogue within the 'European League Against Rheumatism study group on OA' and People with Arthritis/Rheumatism across Europe (PARE) representatives.

  7. Robust optimization of a mathematical model to design a dynamic cell formation problem considering labor utilization

    Science.gov (United States)

    Vafaeinezhad, Moghadaseh; Kia, Reza; Shahnazari-Shahrezaei, Parisa

    2016-11-01

    Cell formation (CF) problem is one of the most important decision problems in designing a cellular manufacturing system includes grouping machines into machine cells and parts into part families. Several factors should be considered in a cell formation problem. In this work, robust optimization of a mathematical model of a dynamic cell formation problem integrating CF, production planning and worker assignment is implemented with uncertain scenario-based data. The robust approach is used to reduce the effects of fluctuations of the uncertain parameters with regards to all possible future scenarios. In this research, miscellaneous cost parameters of the cell formation and demand fluctuations are subject to uncertainty and a mixed-integer nonlinear programming model is developed to formulate the related robust dynamic cell formation problem. The objective function seeks to minimize total costs including machine constant, machine procurement, machine relocation, machine operation, inter-cell and intra-cell movement, overtime, shifting labors between cells and inventory holding. Finally, a case study is carried out to display the robustness and effectiveness of the proposed model. The tradeoff between solution robustness and model robustness is also analyzed in the obtained results.

  8. Inverse problem of HIV cell dynamics using Genetic Algorithms

    Science.gov (United States)

    González, J. A.; Guzmán, F. S.

    2017-01-01

    In order to describe the cell dynamics of T-cells in a patient infected with HIV, we use a flavour of Perelson's model. This is a non-linear system of Ordinary Differential Equations that describes the evolution of healthy, latently infected, infected T-cell concentrations and the free viral cells. Different parameters in the equations give different dynamics. Considering the concentration of these types of cells is known for a particular patient, the inverse problem consists in estimating the parameters in the model. We solve this inverse problem using a Genetic Algorithm (GA) that minimizes the error between the solutions of the model and the data from the patient. These errors depend on the parameters of the GA, like mutation rate and population, although a detailed analysis of this dependence will be described elsewhere.

  9. Challenges in Education Research in Taiwan: Research Institutes and Organizations, Research Policies, and Problems

    Directory of Open Access Journals (Sweden)

    Jia Li Huang

    2017-02-01

    Full Text Available Since the 1990s, many education researchers and policy makers worldwide have reviewed education research to attempt to provide strategies to improve the quality of such research in their countries. Taiwan’s government has launched policies and funded support to set the benchmark for Taiwan’s leading universities in international academic competition. The external environment of global competition based on research policy influences the ecosystem of social science research production. To assure the quality of education policy, peer review from within the education community is one approach to supplementing the government’s governance, including the establishment of research institutes, promotion, rewards, and research value. This study tracked the mode of academic research and provides an overview of the status of academic education research in Taiwan. Because education research is part of the humanities and social sciences fields, this study identified the challenges in educational research by examining the trend of social science research and by analyzing research organizations, policy, and the evaluation of research performance. Due to the environment of education research in Taiwan is not friendly to education researcher to accumulate papers in SSCI or international journal, additional concerns entail how education research communities can develop and agree on its quality.

  10. Thyroid cell lines in research on goitrogenesis.

    Science.gov (United States)

    Gerber, H; Peter, H J; Asmis, L; Studer, H

    1991-12-01

    Thyroid cell lines have contributed a lot to the understanding of goitrogenesis. The cell lines mostly used in thyroid research are briefly discussed, namely the rat thyroid cell lines FRTL and FRTL-5, the porcine thyroid cell lines PORTHOS and ARTHOS, The sheep thyroid cell lines OVNIS 5H and 6H, the cat thyroid cell lines PETCAT 1 to 4 and ROMCAT, and the human thyroid cell lines FTC-133 and HTh 74. Chinese hamster ovary (CHO) cells and COS-7 cells, stably transfected with TSH receptor cDNA and expressing a functional TSH receptor, are discussed as examples for non-thyroidal cells, transfected with thyroid genes.

  11. Research Problems in Data Curation: Outcomes from the Data Curation Education in Research Centers Program

    Science.gov (United States)

    Palmer, C. L.; Mayernik, M. S.; Weber, N.; Baker, K. S.; Kelly, K.; Marlino, M. R.; Thompson, C. A.

    2013-12-01

    The need for data curation is being recognized in numerous institutional settings as national research funding agencies extend data archiving mandates to cover more types of research grants. Data curation, however, is not only a practical challenge. It presents many conceptual and theoretical challenges that must be investigated to design appropriate technical systems, social practices and institutions, policies, and services. This presentation reports on outcomes from an investigation of research problems in data curation conducted as part of the Data Curation Education in Research Centers (DCERC) program. DCERC is developing a new model for educating data professionals to contribute to scientific research. The program is organized around foundational courses and field experiences in research and data centers for both master's and doctoral students. The initiative is led by the Graduate School of Library and Information Science at the University of Illinois at Urbana-Champaign, in collaboration with the School of Information Sciences at the University of Tennessee, and library and data professionals at the National Center for Atmospheric Research (NCAR). At the doctoral level DCERC is educating future faculty and researchers in data curation and establishing a research agenda to advance the field. The doctoral seminar, Research Problems in Data Curation, was developed and taught in 2012 by the DCERC principal investigator and two doctoral fellows at the University of Illinois. It was designed to define the problem space of data curation, examine relevant concepts and theories related to both technical and social perspectives, and articulate research questions that are either unexplored or under theorized in the current literature. There was a particular emphasis on the Earth and environmental sciences, with guest speakers brought in from NCAR, National Snow and Ice Data Center (NSIDC), and Rensselaer Polytechnic Institute. Through the assignments, students

  12. Treatment for alcohol-related problems: special populations: research opportunities.

    Science.gov (United States)

    Gomberg, Edith S Lisansky

    2003-01-01

    For the subgroups indicated, a few questions/issues are relevant to all three (women, elderly, minorities): 1. Heterogeneity of the special populations, for example, Hispanic-Americans are from different countries with different cultures. Women and the elderly vary by age, education, income, social class, health status, etc., to say nothing of ethnicity/color/religion. 2. Of therapy modalities, professional and indigenous, which are more efficacious? 3. Are group-specific therapies needed, or will sensitivity to a particular group work as well? WOMEN: Stereotypes and myths have prevailed, for example, the long-standing belief that women have poorer prognoses than male alcoholics. When female and male alcoholics are compared, women report more positive family history, a later onset of drinking and problems, more marital disruption, more comorbidity, etc. The review of treatment outcomes (Vannicelli, 1986) showed few significant gender differences in outcomes. Research recommendations include biological and genetic studies, women's view of and use of therapeutic modalities, and outcome studies of different modalities, including all female facilities. ELDERLY: Medications are used more by older patients, and such patients are more likely to experience adverse drug reactions. In the moderate social use of alcohol, there are conflicting reports and the extent of elderly use awaits decisive study. The etiology of problem drinking by older persons is studied rarely. An attempt has been made to explain onset later in life (vs. earlier onset) based on the stresses of aging (loss, loneliness, health problems, etc.); research results have not been supportive. Consequences of older persons' heavy drinking seems to be most often alcohol-related medical disorders, although there are often familial and social consequences. Atkinson (1995) recommended the development of elder-specific outcome measures, study of the efficacy of different treatment modalities, and study of the

  13. Research status of direct methanol fuel cell and current key problems%直接甲醇燃料电池研究现状及主要问题

    Institute of Scientific and Technical Information of China (English)

    李建玲; 毛宗强

    2001-01-01

    直接甲醇燃料电池(DMFC)具有燃料易运输与存储、重量轻、体积小、结构简单、能量效率高等优点,以固体聚合物作为电解质的直接甲醇燃料电池是理想的车用动力电源,具有广阔的发展前景。从DMFC性能研究、甲醇穿过Nafion膜渗透的影响、膜研究及电催化剂研究等四个方面描述了直接甲醇燃料电池的研究现状及存在的主要问题,结合当前的最新研究成果,给出DMFC研究中需要解决的几个关键问题。%Direct methanol fuel cells (DMFC) had several advantagesincluding ease transportation and storage of the fuel,reduced system weight,size and complexity,high energy efficiency.Polymer electrolyte membrane direct methanol fuel cells (PEMDMFC) were ideal power source for vehicles with bright prospects to be expected.The state-of-art and problems in the fields of DMFC performance,the impact of methanol crossover across the Nafion membrane,membrane and eletrocatalysts were described.Several key problems needed to be solved in the study of DMFC were suggested according to recent advances.

  14. Setting FIRES to Stem Cell Research

    Science.gov (United States)

    Miller, Roxanne Grietz

    2005-01-01

    The goal of this lesson is to present the basic scientific knowledge about stem cells, the promise of stem cell research to medicine, and the ethical considerations and arguments involved. One of the challenges of discussing stem cell research is that the field is constantly evolving and the most current information changes almost daily. Few…

  15. Setting FIRES to Stem Cell Research

    Science.gov (United States)

    Miller, Roxanne Grietz

    2005-01-01

    The goal of this lesson is to present the basic scientific knowledge about stem cells, the promise of stem cell research to medicine, and the ethical considerations and arguments involved. One of the challenges of discussing stem cell research is that the field is constantly evolving and the most current information changes almost daily. Few…

  16. Research of Flexible Robotic Manufacturing Cell Scheduling Problem Based on Hybrid Genetic Algorithm%基于遗传算法的柔性机器人制造单元调度问题研究

    Institute of Scientific and Technical Information of China (English)

    龙传泽; 杨煜俊

    2015-01-01

    考虑机器人在装载站、机床、卸载站三者间搬运时间和空载时间的情况下求解柔性机器人制造单元Job-shop类型调度问题,目标是求所有工件加工完成并搬至卸载站的最短时间. 首先,在分析机器人制造单元调度问题特点的基础上建立其数学模型,提出了一种新的对机器人搬运工序排序组成搬运序列矩阵的调度方法,机器人按搬运序列搬运,机床则按先到先服务规则( FCFS )加工;然后针对这种调度方法提出了一种改进遗传算法,为遗传算法设计了一种基于搬运工序编码方法与启发式分配策略,设计了一种启发式搬运矩阵调整方法,最后,把启发式调整算法与遗传算法结合组成混合算法对调度问题进行求解,通过标准算例计算,验证了算法的有效性.%Considering the transport time of robot among loading station machine and unloading station to solve flexible robotic manufacturing cell scheduling problem . The goal is to find the shortest time for all workpiece is completed and moved to unload station. Firstly, mathematical model is established based on a-nalysis of the characteristics of flexible robot manufacturing cell scheduling problems. A new scheduling method based on sequence matrix of robot transport operation is proposed, machine processing is based on first come first serve rule ( FCFS); Then, an improved genetic algorithm is proposed for this scheduling method ,handling procedure code method and heuristic assignment strategy for genetic algorithm is designed, heuristic handling sequence adjustment algorithm is proposed;Finally, heuristic algorithm is combined with genetic algorithm to build hybrid algorithm to solve this scheduling problem, through the standard example calculation, verified the effectiveness of the algorithm.

  17. Population problems and population research in a market economy.

    Science.gov (United States)

    Tian, X

    1994-01-01

    A market driven economy has many effects on population growth. The laws of social production were explicated by Marx and Engels, and Comrade Deng Xiaoping presents his views on China's socialist market economy and population problems in this article. Modern market economies have changed greatly over time. Before the 1960s, the focus of the interaction between population and economic change was in macro control. Since the 1960s, the focus shifted to micro control. Theories on maximum growth and neomodern population theory provide only a few useful elements. Cost-benefit analysis of child production functions, despite limitations, has universal appeal. Western theories with sound scientific evidence and Marxist theories should be examined and integrated within the Chinese experience. Two areas of concern in China are the spatial imbalance between population and economic development and an appropriate time period for any research activity. Scientific research in China will be advanced by careful integration of theory and practice, careful study of the Chinese experience, in-depth analysis, and bold, practical approaches which incorporate existing research results from the West. There are three dominant views of economic reforms. 1) Economic development plans should include a market economy. 2) Chinese population control would depend upon administrative means rather than market forces. 3) There are indirect ways in which the market affects population production. The last position is favored. The conclusions are made that family planning has been and continues to be a driving force in declining birth rates and that a focus on government population control does not discount the importance of the influence of economic factors on changes in the birth rate. Market forces are beginning to show their impact on people's choice in reproduction, and the impact is increasing. Reforms must be made appropriate to both the position and the negative influence of the market economy on

  18. Applications of systems thinking and soft operations research in managing complexity from problem framing to problem solving

    CERN Document Server

    2016-01-01

    This book captures current trends and developments in the field of systems thinking and soft operations research which can be applied to solve today's problems of dynamic complexity and interdependency. Such ‘wicked problems’ and messes are seemingly intractable problems characterized as value-laden, ambiguous, and unstable, that resist being tamed by classical problem solving. Actions and interventions associated with this complex problem space can have highly unpredictable and unintended consequences. Examples of such complex problems include health care reform, global climate change, transnational serious and organized crime, terrorism, homeland security, human security, disaster management, and humanitarian aid. Moving towards the development of solutions to these complex problem spaces depends on the lens we use to examine them and how we frame the problem. It will be shown that systems thinking and soft operations research has had great success in contributing to the management of complexity. .

  19. Problem-Based Learning in an Eleventh Grade Chemistry Class: "Factors Affecting Cell Potential"

    Science.gov (United States)

    Tarhan, Leman; Acar, Burcin

    2007-01-01

    The purpose of this research study was to examine the effectiveness of problem-based learning (PBL) on eleventh grade students' understanding of "The effects of temperature, concentration and pressure on cell potential" and also their social skills. Stratified randomly selected control and experimental groups with 20 students each were used in…

  20. Cyclic flow shop scheduling problem with two-machine cells

    Directory of Open Access Journals (Sweden)

    Bożejko Wojciech

    2017-06-01

    Full Text Available In the paper a variant of cyclic production with setups and two-machine cell is considered. One of the stages of the problem solving consists of assigning each operation to the machine on which it will be carried out. The total number of such assignments is exponential. We propose a polynomial time algorithm finding the optimal operations to machines assignment.

  1. 干细胞再生生物学研究悖论及相关法律问题探讨%Discuss of Stem Cell Regenerative Biology Research Paradox and Problems Related Law

    Institute of Scientific and Technical Information of China (English)

    杨荣华; William Isaacs; 徐学红; 李忠光; 崔婧; 王荣荣; 王春慧; 牟玉莲; Hiroshi Takeshima; MengMeng Xu; 刘万红

    2016-01-01

    Stem cells have a pluripotency to develop to over 250 different cells composed of human body.This characteristic makes a great promise for human being to conquer life threatening diseases entirely and meanwhile brings rigorous challenging.Uncertainty on stem cell research needs more solid data from animal pre-clinic experiments.Issues on challenge of scientific medical workers’ ethics, inexact scientific experi-ments argument and dishonest research reports etc need to be put an end to so as to speed up the pace of stem cell regenerative biology from basic and clinical trials to cure patients.The formulation of related laws and regulations of stem cells clinical application must learn from the experience of developed countries and set up legal committees related stem cell application at least including senior scholars of legal profession, experts on medical ethics, front-line researchers of regenerative biology and policy makers.It is urgent to promulgate legal provisions in accordance with the national conditions.%干细胞可分化为构成人体的250余种细胞,这一特性为彻底攻克人类疾病带来了极大的希望,然而,现阶段也存在大量亟待解决的问题。干细胞基础研究结果应用于临床试验还有许多问题没有解决,仍然需要包括动物实验等中间试验在内的数据积累。干细胞应用前期的临床试验面临的科研人员职业道德的挑战、科学实验立论不够严谨、急功近利的虚假研究报道等问题必须坚决杜绝,在此基础上才能加快干细胞再生生物学从基础及临床试验走向临床应用的步伐。中国干细胞临床应用相关的法律法规必须借鉴发达国家的经验,组建至少包括法律界资深学者、医学伦理学专家、再生生物学领域的一线科研工作者和政治政策的制定者在内的干细胞应用相关法律委员会,颁布符合国情的法律。

  2. Classroom Discipline Problems and Reality Therapy: Research Support

    Science.gov (United States)

    Cates, Jean T.; Gang, Mark J.

    1976-01-01

    Reports the methods and results of two studies on the successful application of reality therapy (RT) to classroom discipline problems. Results indicate RT is an effective humanizing approach for solving problems. (Author)

  3. Stem cell research in hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Chengyi SUN; Shi ZUO

    2008-01-01

    The traditional view that adult human liver tumors, mainly hepatocellular carcinoma (HCC), arise from mature cell types has been challenged in recent dec-ades. The results of several studies suggest that HCC can be derived from liver stem cells. There are four levels of cells in the liver stem cell lineage: hepatocytes, hepatic stem cells/oval cells, bone marrow stem cells and hepato-pancreas stem cells. However, whether HCC is resulted from the differentiation block of stem cells and, moreover, which liver stem cell lineage is the source cell of hepatocarcinogenesis remain controversial. In this review, we focus on the current status of liver stem cell research and their roles in carcinogenesis of HCC, in order to explore new approaches for stem cell therapy of HCC.

  4. Researching and Working for Transgender Youth: Contexts, Problems and Solutions

    Directory of Open Access Journals (Sweden)

    Tiffany Jones

    2016-08-01

    Full Text Available In May 2016, two events epitomized the complexities of working for global transgender youth rights. First, United Nations Educational Scientific and Cultural Organisation (UNESCO hosted a ministerial event in which education ministers from around the world released a call to action for protection of students on the basis of their gender identity and expression in schools. Second, the United Nations (UN hosted an event celebrating the family, attended by conservative ministers and activists who mobilized family protectionist discourse against transgender students. This article contemplates, in light of transgender activist Raewyn Connell’s Southern Theory contributions, the complexity of global research and work for transgender youth. It considers key informant interviews with 50 stakeholders in the global push for transgender student rights in education, including members of government and non-government organisations, and academics from Northern and Southern countries. Problems in aiding transgender youth at the global level included safety concerns, the impacts of conservative advocates and media backlash (within family and national protectionist discourses, cultural complexities hampering engagement and translation, dissemination hindrances pertaining to established publishing biases, and financial and collaboration barriers. Solutions including virtual work; multi-level leadership; alliance-building; representation; visibility of transgender youth citizenship and family membership; and legal, financial and capacity-building aid are considered.

  5. Cell Phones: Current Research Results

    Science.gov (United States)

    ... Potential Biological or Adverse Health Effects of Wireless Communication Devices World Health Organization: Electromagnetic Fields and Public Health: Mobile Phones International Agency for Research on Cancer Press ...

  6. Prostate Cancer Stem Cells: Research Advances

    Directory of Open Access Journals (Sweden)

    Dagmara Jaworska

    2015-11-01

    Full Text Available Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve the prognosis for patients with advanced stages of the disease.

  7. Cell culture techniques in honey bee research

    Science.gov (United States)

    Cell culture techniques are indispensable in most if not all life science disciplines to date. Wherever cell culture models are lacking scientific development is hampered. Unfortunately this has been and still is the case in honey bee research because permanent honey bee cell lines have not yet been...

  8. The cell method for electrical engineering and multiphysics problems. An introduction

    Energy Technology Data Exchange (ETDEWEB)

    Alotto, Piergiorgio [Padova Univ. (Italy). Dipt. di Ingegneria Industriale; Freschi, Fabio; Repetto, Maurizio [Politecnico di Torino (Italy). Dipt. Energia; Rosso, Carlo [Politecnico di Torino (Italy). Dipt. di Ingegneria Meccanica e Aerospaziale

    2013-03-01

    Introduction to the Cell Method, a numerical method for the solution of a large class of physical problems as an alternative to the classical Finite Element techniques. Presents important implementation aspects of the technique as well as a complete fully working computer code for the solution of three-dimensional stationary thermal problem. All chapters include extensive bibliographic references. This book presents a numerical scheme for the solution of field problems governed by partial differential equations: the cell method. The technique lends itself naturally to the solution of multiphysics problems with several interacting phenomena. The Cell Method, based on a space-time tessellation, is intimately related to the work of Tonti and to his ideas of classification diagrams or, as they are nowadays called, Tonti diagrams: a graphical representation of the problem's equations made possible by a suitable selection of a space-time framework relating physical variables to each other. The main features of the cell method are presented and links with many other discrete numerical methods (finite integration techniques, finite difference time domain, finite volumes, mimetic finite differences, etc.) are discussed. After outlining the theoretical basis of the method, a set of physical problems which have been solved with the cell method is described. These single and multiphysics problems stem from the authors' research experience in the fields of electromagnetism, elasticity, thermo-elasticity and others. Finally, the implementation of the numerical technique is described in all its main components: space-time discretization, problem formulation, solution and representation of the resulting physical fields.

  9. Efficient Parallel Sorting for Migrating Birds Optimization When Solving Machine-Part Cell Formation Problems

    National Research Council Canada - National Science Library

    Soto, Ricardo; Crawford, Broderick; Almonacid, Boris; Paredes, Fernando

    2016-01-01

    The Machine-Part Cell Formation Problem (MPCFP) is a NP-Hard optimization problem that consists in grouping machines and parts in a set of cells, so that each cell can operate independently and the intercell movements are minimized...

  10. TA-designed vs. research-oriented problem solutions

    CERN Document Server

    Lin, Shih-Yin; Mamudi, William; Henderson, Charles R; Yerushalmi, Edit

    2016-01-01

    In order to study graduate teaching assistants (TAs) beliefs and values about the design of instructor problem solutions, twenty-four TAs were provided with different solutions and asked to discuss their preferences for prominent solution features. TAs preferences for solution features were examined in light of the modeling of expert-like problem solving process as recommended in the literature. Results suggest that while many of the features TAs valued align with expert-like problem solving approaches, they noticed primarily "surface features" of solutions. Moreover, self-reported preferences did not match well with the solutions TAs wrote on their own.

  11. The Vaal river catchment: Problems and research needs

    CSIR Research Space (South Africa)

    Braune, E

    1987-01-01

    Full Text Available 500 to 4 000 mg 1-I). Discharge of lime (or soda ash) neutralized brackish mine service water, as well as wastewater from reduction works may present problems to the environment and need to be carefully monitored and controlled. Kine d m... similar problems to pla~ed urban development. Air pollution levels from coal and wood burning are generally high. Solid wastes are mainly an aesthetic problem but could also lead to deterioration in water quality. Lack of proper sewerage leads...

  12. Researching the Film Audience: Purposes, Procedures, and Problems.

    Science.gov (United States)

    Austin, Bruce A.

    Film audience research complements institutional research, verifying scholarship on the meanings films have to viewers and providing broad-based explanations of film images. Most important, such research focuses on the decision and motivation processes people use before they set foot in the movie theater, thereby helping to construct a context…

  13. Trees Without Fruit: The Problem with Research About Higher Education.

    Science.gov (United States)

    Keller, George

    1985-01-01

    "If the research in higher education ended, it would scarcely be missed." This is the time when excellent research and scholarship about higher learning and its institutions is needed, yet the study of this national resource is at a low ebb. The reasons for low appraisals of research are discussed. (MLW)

  14. Embryonic Stem Cell Research: A Policy Analysis.

    Science.gov (United States)

    Warren, Hermine

    Many health care issues generate minimal passion, promoting benign commentary and support from the various stakeholders involved. Stem cell research does not fall into this category, and on the contrary, embryonic stem cell (ESC) research has continued to foster controversy and emotion. Since 1998, which marked the first successful laboratory isolation of ESCs, this research continues to ignite moral, ethical, and legal debate over its efficacy. The focus of this policy analysis is to introduce the issues, examine and address the various perspectives that surround ESC research, and present policy options and/or solutions that may be used to successfully create a policy consensus regarding this much debated topic.

  15. Research Projects in Physics: A Mechanism for Teaching Ill-Structured Problem Solving

    Science.gov (United States)

    Milbourne, Jeff; Bennett, Jonathan

    2017-10-01

    Physics education research has a tradition of studying problem solving, exploring themes such as physical intuition and differences between expert and novice problem solvers. However, most of this work has focused on traditional, or well-structured, problems, similar to what might appear in a textbook. Less work has been done with open-ended, or ill-structured, problems, similar to the types of problems students might face in their professional lives. Given the national discourse on educational system reform aligned with 21st century skills, including problem solving, it is critical to provide educational experiences that help students learn to solve all types of problems, including ill-structured problems.

  16. Research Advances of Social Security Problems in China —Visualization Research based on Bibliometrics

    Institute of Scientific and Technical Information of China (English)

    赵琳

    2016-01-01

    This article summarized the research progress and characteristics of Chinese social security issues from 2000 papers, which record in CNKI. We find that, the topic in the field of social security is board and dispersion. Due to the huge system and complex problem of social security, there is no central theme. Through cluster analysis, multi dimensional scaling analysis and social network analysis, we got the high frequency keywords atlas. Then, we summarized the research topic to six parts. They are rural social security, urban and rural social security co-ordination, vulnerable group social security, social security fund management, the social insurance system, and social security system and government responsibility. It summed up the theme of the module, meanwhile, combined the practice analysis.

  17. Periodic cells for large-scale problem initialization

    Science.gov (United States)

    Ciantia, Matteo O.; Arroyo, Marcos; Zhang, Ningning; Emam, Sacha

    2017-06-01

    In geotechnical applications the success of the discrete element method (DEM) in simulating fundamental aspects of soil behaviour has increased the interest in applications for direct simulation of engineering scale boundary value problems (BVP's). The main problem is that the method remains relatively expensive in terms of computational cost. A non-negligible part of that cost is related to specimen creation and initialization. As the response of soil is strongly dependant on its initial state (stress and porosity), attaining a specified initial state is a crucial part of a DEM model. Different procedures for controlled sample generation are available. However, applying the existing REV-oriented initialization procedures to such models is inefficient in terms of computational cost and challenging in terms of sample homogeneity. In this work a simple but efficient procedure to initialize large-scale DEM models is presented. Periodic cells are first generated with a sufficient number of particles matching a desired particle size distribution (PSD). The cells are then equilibrated at low-level isotropic stress at target porosity. Once the cell is in equilibrium, it is replicated in space in order to fill the model domain. After the domain is thus filled a few mechanical cycles are needed to re-equilibrate the large domain. The result is a large, homogeneous sample, equilibrated under prescribed stress at the desired porosity. The method is applicable to both isotropic and anisotropic initial stress states, with stress magnitude varying in space.

  18. IRB Problems and Solutions in Health Communication Research.

    Science.gov (United States)

    King, Carie S Tucker; Bivens, Kristin Marie; Pumroy, Erin; Rauch, Susan; Koerber, Amy

    2017-06-06

    In this article, we contribute to the current literature on the difficulties that social scientists encounter with IRBs, but with a focus on the distinct challenges that health communication scholars face in dealing with IRBs at their own institutions and elsewhere. Although health communication researchers, like other communication researchers, can expect to face many of the same challenges that their social science colleagues face during the IRB process, the researcher narratives we present in this article suggest that health communication research presents some distinct challenges because the communication interactions that we investigate occur in highly protected, private spaces, including the medical exam room, online patient forums, and electronic health records. To that end, we present a series of examples in which health communication researchers were able to find solutions or workarounds to the challenges they faced in gaining IRB approval for their research. In every case that we present, the researcher had to revise her initial study design to get around the constraints imposed by IRB requirements, and in every case, the researcher reports having experienced points of incommensurability similar to those reported by many other social scientists. In some situations, investigators even express frustration that the IRB's needs and demands superseded those of healthcare professionals and the patients whom they serve. Additionally, in some situations, investigators' understandings of human subjects' protection actually go further to protect patients' privacy and confidentiality than the IRB required. But, in all four cases that we present, the health communication research was ultimately successful.

  19. Problems in turbidite research: A need for COMFAN

    Science.gov (United States)

    Normark, W.R.; Mutti, E.; Bouma, A.H.

    1984-01-01

    Comparison of modern submarine fans and ancient turbidite sequences is still in its infancy, mainly because of the incompatibility of study approaches. Research on modern fan systems mainly deals with morphologic aspects and surficial sediments, while observations on ancient turbidite formations are mostly directed to vertical sequences. The lack of a common data set also results from different scales of observation. To review the current status of modern and ancient turbidite research, an international group of specialists formed COMFAN (Committee on Fans) and met in September 1982 at the Gulf Research and Development Company research facilities in Pennsylvania. ?? 1984 Springer-Verlag New York Inc.

  20. RESEARCH ANNOUNCEMENTS On a Spectrum Problem for Analytic Function

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ 1 Introduction Let Ω be the unit disk {z: |z| < 1} in the complex plane C. In this paper, we consider the following boundary value problem: Find out a λ and the analytic function u(z) in the unit disk Ω such that they satisfy the boundary condition

  1. An exploration of knowledge integration problems in interdisciplinary research teams

    NARCIS (Netherlands)

    Bayerl, P.S.; Steinheider, B.

    2009-01-01

    The integration of function-specific expertise into a shared knowledge base is a crucial, but complex process for success in interdisciplinary teams. This paper presents an empirically derived typology of knowledge integration problems and links their occurrence to degree of heterogeneity and presen

  2. Stem Cell Research and Health Education

    Science.gov (United States)

    Eve, David J.; Marty, Phillip J.; McDermott, Robert J.; Klasko, Stephen K.; Sanberg, Paul R.

    2008-01-01

    Stem cells are being touted as the greatest discovery for the potential treatment of a myriad of diseases in the new millennium, but there is still much research to be done before it will be known whether they can live up to this description. There is also an ethical debate over the production of one of the most valuable types of stem cell: the…

  3. Research on Life Science and Life Support Engineering Problems of Manned Deep Space Exploration Mission

    Science.gov (United States)

    Qi, Bin; Guo, Linli; Zhang, Zhixian

    2016-07-01

    Space life science and life support engineering are prominent problems in manned deep space exploration mission. Some typical problems are discussed in this paper, including long-term life support problem, physiological effect and defense of varying extraterrestrial environment. The causes of these problems are developed for these problems. To solve these problems, research on space life science and space medical-engineering should be conducted. In the aspect of space life science, the study of space gravity biology should focus on character of physiological effect in long term zero gravity, co-regulation of physiological systems, impact on stem cells in space, etc. The study of space radiation biology should focus on target effect and non-target effect of radiation, carcinogenicity of radiation, spread of radiation damage in life system, etc. The study of basic biology of space life support system should focus on theoretical basis and simulating mode of constructing the life support system, filtration and combination of species, regulation and optimization method of life support system, etc. In the aspect of space medical-engineering, the study of bio-regenerative life support technology should focus on plants cultivation technology, animal-protein production technology, waste treatment technology, etc. The study of varying gravity defense technology should focus on biological and medical measures to defend varying gravity effect, generation and evaluation of artificial gravity, etc. The study of extraterrestrial environment defense technology should focus on risk evaluation of radiation, monitoring and defending of radiation, compound prevention and removal technology of dust, etc. At last, a case of manned lunar base is analyzed, in which the effective schemes of life support system, defense of varying gravity, defense of extraterrestrial environment are advanced respectively. The points in this paper can be used as references for intensive study on key

  4. Problems Teachers Face When Doing Action Research and Finding Possible Solutions: Three Cases

    Science.gov (United States)

    Zhou, Jun

    2012-01-01

    Through case studies, this paper explores problems teachers face when doing action research: for instance, teachers may misunderstand the research, mistrust university researchers, lack the time or adequate library resources to conduct research, lack theoretical guidance or knowledge of research methodology, and feel pressure or frustration during…

  5. Sickle Cell Screening: Medical, Legal, Ethical, Psychological and Social Problems; A Sickle Cell Crisis.

    Science.gov (United States)

    Bowman, James E.

    In recent years, sickle cell screening programs have been initiated by community groups, health centers, hospitals, medical schools, health departments, school systems, city and State governments, various branches of the Federal Government, fraternal and social clubs, and other organizations. Problems have resulted from mass sickle cell screening,…

  6. RESEARCH ANNOUNCEMENTS Helly Type Problems for Some Special Convex Polygons

    Institute of Scientific and Technical Information of China (English)

    苑立平; 丁仁

    2001-01-01

    @@In the combinatorial geometry of convex sets the question of how efficiently a family of convex sets can be pierced by points has led to various problems which may be regarded as extensions of the Helly-type problems. A family of sets is said to be n-pierceable (abbreviated as Пn) if there exists a set of n points such that each member of the family contains at least one of them. A family of sets is said to be Пnk if every subfamily of size k or less is Пn. The famous Helly theorem in combinatorial geometry asserts that for finite families of convex sets in the plane П13 implies П1. In a recent paper by M. Katchalski and D. Nashtir[a] the following conjecture of Griinbaum[2] was mentioned again:

  7. RESEARCH OF PROBLEMS ON REALIZING DIRECT ALGORITHM OF WAVELET TRANSFORM

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Direct algorithm of wavelet transform (WT) is the numerical algorithm obtained from the integral formula of WT by directly digitization.Some problems on realizing the algorithm are studied.Some conclusions on the direct algorithm of discrete wavelet transform (DWT), such as discrete convolution operation formula of wavelet coefficients and wavelet components, sampling principle and technology to wavelets, deciding method for scale range of wavelets, measures to solve edge effect problem, etc, are obtained.The realization of direct algorithm of continuous wavelet transform (CWT) is also studied.The computing cost of direct algorithm and Mallat algorithm of DWT are still studied, and the computing formulae are obtained.These works are beneficial to deeply understand WT and Mallat algorithm.Examples in the end show that direct algorithm can also be applied widely.

  8. Issues and ethical problems of stem cell therapy--where is Hippocrates?

    Science.gov (United States)

    Rousková, Lucie; Hruska, Ivan; Filip, Stanislav

    2008-01-01

    Stem cells and their therapeutic use present many questions associated with ethical problems in medicine. There is great effort on the part of physicians to help millions of patients while there are ethical problems with the use of new methods and technologies and all of these are affected by economic and political influences. How will the current generation deal with these problems? Medicine, in this begard, is experiencing a stormy evolution of human culture in the relationships between disease, patient and doctor. Philosophy approaches the same juncture of human culture, but seemingly from the other side. Both disciplines are facing a great problem: How to unite the content of current human morality and the desire for health? Both philosophers and physicians perceive this deficit in human culture as it does not provide immediately usable normatives, which the living generation of healthy and ill is waiting for. It may be said that medicine, as many times before, has reached a stage where it cannot rely only on the proved axiologic values from the past, ethical normatives or cultivated moral sense of its subjects. Medicine has no other alternative than to take an active part in resolution of interdisciplinary problems originating from philosophic-biologic or philosophic-medical inquiries of axiologic, ethical, and moral issues. Our paper indicates some ways of the search in forming ethical principles of the stem-cell therapy from the view of biologists and physicians. New ways are recommended in theoretical-methodological interdisciplinary research, especially, in theoretical and experimental biology, and theoretical and clinical medicine, as well as philosophy. In this paper important ethical problems are pointed out in order to find answers to some key problems connected with cell therapy and the use of stem cells.

  9. Understanding Acquisition Cycle Time: Focusing the Research Problem

    Science.gov (United States)

    2013-11-01

    including requisite skills, tools, and information) exercised could many problems be averted? Alternatively, are extreme schedule and cost growth more...internal management would be less culpable or able to address program schedule and cost impacts. One useful exercise might be to assess extreme outcomes...Leon-Girard R., and Burton E. McKenzie . Lessons Learned in USAF Weapon System Acquisition Management: A Case Study Approach. MS thesis, School of

  10. Social Problem Solving Skill Research and Social-Skill Training

    OpenAIRE

    一前, 春子

    1996-01-01

    Reseach on the relation between social information-processing and social adjustment in childhood is reviewed and interpreted within the framework of social informationprocessing model and INS model.The review suggests that two models have different useful aspects. Then, efforts of social-skill training and their effects on children are examined.Results of social-skill training indicates that both children with problems and normal children receive benefit.

  11. Problems and pitfalls in a clinical research data management system.

    Science.gov (United States)

    Brower, R W; ten Katen, H J; Meester, G T

    1984-01-01

    The problems and pitfalls encountered in the computerized data bank for the Netherlands Coronary Surgery (NCS) study are reviewed. This study involved 848 patients seen before coronary artery surgery and at 1 and 3 yr after surgery. Nineteen data forms were used resulting in maximally 1142 variables per patient. The importance of quality control is emphasized as well as the efficient transfer of information from data bank to statistical processing.

  12. Research briefing on contemporary problems in plasma science

    Science.gov (United States)

    1991-01-01

    An overview is presented of the broad perspective of all plasma science. Detailed discussions are given of scientific opportunities in various subdisciplines of plasma science. The first subdiscipline to be discussed is the area where the contemporary applications of plasma science are the most widespread, low temperature plasma science. Opportunities for new research and technology development that have emerged as byproducts of research in magnetic and inertial fusion are then highlighted. Then follows a discussion of new opportunities in ultrafast plasma science opened up by recent developments in laser and particle beam technology. Next, research that uses smaller scale facilities is discussed, first discussing non-neutral plasmas, and then the area of basic plasma experiments. Discussions of analytic theory and computational plasma physics and of space and astrophysical plasma physics are then presented.

  13. Structural dialectical approach in psychology: problems and research results

    Directory of Open Access Journals (Sweden)

    Veraksa, Nikolay E.

    2013-06-01

    Full Text Available In this article dialectical thinking is regarded as one of the central cognitive processes. Because of this cognitive function we can analyze the development of processes and objects. It also determines the possibilities for the creative transformation of some content and for solving problems. The article presents a description and the results of experimental studies. This evidence proves that dialectical thinking is a specific line of cognitive development in children and adults. This line can degrade during school time if the educational program follows formal logical principles, or it can become significantly stronger if the pedagogy is based on dialectical methodology.

  14. Multispecies networks: visualizing the psychological research of the Committee for Research in Problems of Sex.

    Science.gov (United States)

    Pettit, Michael; Serykh, Darya; Green, Christopher D

    2015-03-01

    In our current moment, there is considerable interest in networks, in how people and things are connected. This essay outlines one approach that brings together insights from actor-network theory, social network analysis, and digital history to interpret past scientific activity. Multispecies network analysis (MNA) is a means of understanding the historical interactions among scientists, institutions, and preferred experimental animals. A reexamination of studies of sexual behavior funded by the Committee for Research in Problems of Sex between the 1920s and the 1940s demonstrates the applicability of MNA to clarifying the relations that sustained this area of psychology. The measures of weighted degree and betweenness can highlight which nodes (whether organisms or institutions) were particularly "central" to this network. Rats featured as the animals most widely studied during this period, but the analysis also reveals distinct institutional and disciplinary cultures where different species were favored as either surrogates for humans or representatives of more general biological groups.

  15. [Ethical problems raised by new reproductive biotechnologies and stem cells].

    Science.gov (United States)

    Le Douarin, Nicole M

    2015-01-01

    Research about the hormonal mechanisms controlling reproduction in mammals has soared during the first half of the 20th century. It has produced a series of discoveries with important outcomes, not only scientific, but also impacting the ways of life. Besides the advent of the contraceptive pill, it has permitted to isolate and cultivate in vitro the female gamete, to fertilize it, thus obtaining a zygote that continues to develop until the blastocyst stage outside the maternal organism. The embryo, transferred into a foster-mother, develops normally until term: the first "test-tube baby" was born in this way in 1978. But the only fact of being able to cultivate the human egg in vitro was to open other possibilities and allow further biological advances: embryonic stem cells (ES cells) obtained from blastocysts and, more recently, from induced Pluripotent Stem cells (iPS), which can potentially be derived from all types of differentiated cell types obtained from adult individuals. From then on, the advent of a new medicine could be anticipated, regenerative because able to replace deficient or absent cells within the organism. As each of these steps was reached, scientists have encountered vigorous opposition from the people: the new potentials disturbed the conceptions that man had of his relationship to nature, in particular in two sensitive domains: sexuality and reproduction. The progress of science has however been accepted by most as soon as it was understood that humanity could anticipate advantages from these advances.

  16. Optical voltage sensors: principle, problem and research proposal

    Science.gov (United States)

    Li, Changsheng

    2016-10-01

    Sensing principles and main problems to be solved for optical voltage sensors are briefly reviewed. Optical effects used for voltage sensing usually include electro-optic Pockels and Kerr effects, electro-gyration effect, elasto-optical effect, and electroluminescent effects, etc. In principle, typical optical voltage sensor is based on electro-optic Pockels crystals and closed-loop signal detection scheme. Main problems to be solved for optical voltage sensors include: how to remove influence of unwanted multiple optical effects on voltage sensing performance; how to select or develop a proper voltage sensing material and element; how to keep optical phase bias to be stable under temperature fluctuation and vibration; how to achieve dc voltage sensing, etc. In order to suppress the influence of unwanted optical effects and light beam coupling-related loss on voltage sensing signals, we may pay more attention to all-fiber and waveguide voltage sensors. Voltage sensors based on electroluminescent effects are also promising in some application fields due to their compact configuration, low cost and potential long-term reliability.

  17. Graduate Social Work Students' Attitudes toward Research: Problems and Prospects

    Science.gov (United States)

    Morgenshtern, Marina; Freymond, Nancy; Agyapong, Samuel; Greeson, Clare

    2011-01-01

    This study examines the attitudes of graduate social work students toward research in the contexts of academic study, professional social work practice, and students' personal lives. The authors collected quantitative and qualitative data from MSW students (n = 102) at a major Canadian school of social work. Findings suggest that MSW students…

  18. Fisheye Interfaces—Research Problems and Practical Challenges

    DEFF Research Database (Denmark)

    Jakobsen, Mikkel Rønne; Hornbæk, Kasper Anders Søren

    2011-01-01

    Fisheye interfaces give access to a large information structure by providing users with both local detail and global context. Despite decades of research in fisheye interfaces, their design and use are not well understood. To foster a discussion of fisheye views and their theoretical foundations,...

  19. INFORMATION ASPECTS OF EDUCATIONAL RESEARCH EXPERIMENTAL PROBLEMS IN ELECTRODYNAMICS

    Directory of Open Access Journals (Sweden)

    Tchernykh A. G.

    2014-06-01

    Full Text Available The article discusses the experimental task, the analysis of which cannot be carried out without the use of methods of calculus mathematics. It is shown that the use of modern information technology in educational research tasks to confront theory with real physical experiments lets us raise the level of quality of training future teachers of physics and computer science

  20. Television in South Africa: The Research Paradox, Problem and Potential.

    Science.gov (United States)

    Harrison, Randall; Ekman, Paul

    South Africa, the last urban, industrial, Western-culture society without television, called for television introduction on January 1, 1976. Thus, South Africa represented the last chance to explore certain research questions about the impact of television in modern societies. A study was made of: (1) factors in the South African context which…

  1. Fisheye interfaces—research problems and practical challenges

    DEFF Research Database (Denmark)

    Jakobsen, Mikkel Rønne; Hornbæk, Kasper

    2009-01-01

    Fisheye interfaces give access to a large information structure by providing users with both local detail and global context. Despite decades of research in fisheye interfaces, their design and use are not well understood. To foster a discussion of fisheye views and their theoretical foundations...

  2. Stem Cell Research: Unlocking the Mystery of Disease

    Science.gov (United States)

    ... Home Current Issue Past Issues From the Director: Stem Cell Research: Unlocking the Mystery of Disease Past Issues / ... Zerhouni, NIH Director, described the need for expanding stem cell research. Recently, he spoke about stem cell research ...

  3. Ufa scientific school by e. a. Mukhacheva: applied operational research problems

    OpenAIRE

    Filippova, A.; Valiakhmetova, Yu; Karamova, L.

    2013-01-01

    The Ufa Scientific Group busy with the research of cutting-packing problems was founded more than 50 years ago in the Ufa Aviation Institute. The class of cutting-packing problems includes problems of various applied interpretation. They are regarded as NP-hart problems, and development and research of effective methods of their solution is actual nowadays. This paper is devoted to the review of the basic problems and the methods of their solution developed under the guidance of Prof. E. A. M...

  4. Latest Sickle Cell Research | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... this page please turn Javascript on. Special Section: Sickle Cell Disease Latest Sickle Cell Research Past Issues / Winter 2011 Table of Contents ... Complications of sickle cell trait 100 Years of Sickle Cell Research Dr. James B. Herrick Photo: National Library ...

  5. PROBLEMS AND OUTLOOK OF RESEARCH ACTIVITIES IN KAZAKHSTAN

    Directory of Open Access Journals (Sweden)

    Botagoz Turdalieva

    2013-10-01

    Full Text Available Performance evaluation of scientific work on regional and individual levels can be achieved by the using scientometric methods of a quantitative analysis of bibliographic information available in such databases as Science Citation Index (SCI. Unfortunately, Kazakhstan scientific journals have not been included yet in the Thomson Reuters Corp. register of periodicals, that substantially distorts the actual national scientometric indexes. The analysis of Database “National Citation Reports” (Kazakhstan, which correlated with a contribution of Kazakhstan into the world science development, has shown the low level of research activities of Kazakhstan scientists on international arena. So, the share of international publications of Kazakhstan in the global flow is equal to 0,021 % (1044 doc. that corresponds to the 87th place in the general list of countries of 177 names. Subject to the ranking of countries into groups by the number of the published works, Kazakhstan is referring to the group of 46 countries having 1000-10000 publications over 5 years, of which 8,6% in  medicine. In this article the use of statistics and appropriate software by the authors of original articles in such journals as recommended by the Kazakh National Centre for Scientific & Technical Expertise (NCSTE and included in the Database еlibrary.kz was evaluated. Research was conducted according to Research Report, due to which a research design and statistical analysis methods were estimated.  In the rating of the research design, the authors of articles mostly used as follows: description of a series of cases–63,2%, description of the individual cases -27,1%, and description of specific cases–9,1%. A scope of selection in Section “Research Methods” was only calculated in 21,8% of cases, and in 63,9% of cases there was no description how the selection was carried out. Methods of analytical statistics were used in the 46,0% of cases. And there were references to

  6. Advances in research of stress-assisted corrosion fatigue problem

    Institute of Scientific and Technical Information of China (English)

    TANG Zhi-bo; LI Qiang

    2007-01-01

    Ceramic materials are notable for their rigidity, insulation and resistance to hostile environment. Nevertheless, if a stressed ceramic component is exposed to chemical attack, it may suffer from a form of delayed fracture known as static fatigue.From the point of view of a designer, it is clearly desirable to determine the behavior of sub-critical crack growth; the crack path and crack growth rate, as a function of material properties and loading conditions are of particular interest. This paper presents a review of advances in stress assisted corrosion problem in history and its corresponding numerical approaches in the last decades,and finally, comes up with consideration and crucial suggestions for future work.

  7. Problems of integrating between innovative enterprises and a researching university

    Directory of Open Access Journals (Sweden)

    Andrey Gennadyevich Svetlakov

    2011-03-01

    Full Text Available The problems that currently face the establishments of agriculture are the following: competition with import products, regionalization of support, i.e. prevention to a single market space formation, monopolization of processing enterprises and sensitivity to investments. The technique of assessing the level of economic security of the agroindustrial complex organizations was suggested and described. It identifies the indicators of economic security, indicative markers of economic security and thresholds for performance indicators, current values of performance indicators etc. At the same time, such indicators of economic security of agroindustrial complex organizations are used: availability of arable land, labour, funds etc.; profitability, efficiency, and cost effectiveness. This technique will reduce the risks to economic security of agroindustrial complex organizations, improve quality of life and enhance food security of the state.

  8. Status, problems and future directions of research in volleyball

    Directory of Open Access Journals (Sweden)

    Stankiewicz Błażej

    2013-12-01

    Full Text Available Purpose . To analyse of publications on various aspects of volleyball and identify the most promising areas of research. Material and methods . As information sources were selected journals from different databases, full-text catalogs and libraries. Results . It is noted that the selection and training process of young volleyball players largely determines the level of club and national teams. In this case, the application of modern techniques, systems and approaches to research is a key component of the success of the team and the level of training of talented volleyball players. Found that the combination of sports orientation and quality of life of young people through passion volleyball helps educate conscious attitude towards their health and desire for high professional achievements. Conclusions . Promising areas should be recognized, such as: improving orientation sessions volleyball; biomechanical prerequisites of development and realization of motor actions, adaptation of existing technical facilities for volleyball.

  9. Prospets of stem cell research and regeneration medicine

    Institute of Scientific and Technical Information of China (English)

    QING Chun; LU Shu-liang

    2012-01-01

    Since the new century,stem cell research has become a hot field in medicine and life science.Scientists in Harvard Plans Stem Cell Center in 2004 have dreamed that one day they can lead stem cells to grow into tissues and even organs in the lab,which can be used to replace the damaged tissues or organs in severe injuries or applied in diseases at the end stage(incurable diseases)in order to prolong the life time and improve the life quality of patients.But this is a long way full of difficulties! Nevertheless,the stem cell research has helped our mankind to understand how single cells grow and develop into tissues as well as organs,and how healthy cells replace the damaged cells in adult body and so on,which induces us to explore the way of treating diseases on cell levels(repairing or regeneration medicine as we usually say)because gene therapies have many unsolved problems.

  10. A genetic algorithm for a bi-objective mathematical model for dynamic virtual cell formation problem

    Science.gov (United States)

    Moradgholi, Mostafa; Paydar, Mohammad Mahdi; Mahdavi, Iraj; Jouzdani, Javid

    2016-05-01

    Nowadays, with the increasing pressure of the competitive business environment and demand for diverse products, manufacturers are force to seek for solutions that reduce production costs and rise product quality. Cellular manufacturing system (CMS), as a means to this end, has been a point of attraction to both researchers and practitioners. Limitations of cell formation problem (CFP), as one of important topics in CMS, have led to the introduction of virtual CMS (VCMS). This research addresses a bi-objective dynamic virtual cell formation problem (DVCFP) with the objective of finding the optimal formation of cells, considering the material handling costs, fixed machine installation costs and variable production costs of machines and workforce. Furthermore, we consider different skills on different machines in workforce assignment in a multi-period planning horizon. The bi-objective model is transformed to a single-objective fuzzy goal programming model and to show its performance; numerical examples are solved using the LINGO software. In addition, genetic algorithm (GA) is customized to tackle large-scale instances of the problems to show the performance of the solution method.

  11. Discovery of HeLa Cell Contamination in HES Cells: Call for Cell Line Authentication in Reproductive Biology Research.

    Science.gov (United States)

    Kniss, Douglas A; Summerfield, Taryn L

    2014-08-01

    Continuous cell lines are used frequently in reproductive biology research to study problems in early pregnancy events and parturition. It has been recognized for 50 years that many mammalian cell lines contain inter- or intraspecies contaminations with other cells. However, most investigators do not routinely test their culture systems for cross-contamination. The most frequent contributor to cross-contamination of cell lines is the HeLa cell isolated from an aggressive cervical adenocarcinoma. We report on the discovery of HeLa cell contamination of the human endometrial epithelial cell line HES isolated in our laboratory. Short tandem repeat analysis of 9 unique genetic loci demonstrated molecular identity between HES and HeLa cells. In addition, we verified that WISH cells, isolated originally from human amnion epithelium, were also contaminated with HeLa cells. Inasmuch as our laboratory did not culture HeLa cells at the time of HES cell derivations, the source of contamination was the WISH cell line. These data highlight the need for continued diligence in authenticating cell lines used in reproductive biology research. © The Author(s) 2014.

  12. The research and demonstration of some major geological problems of Three Gorges Project%The research and demonstration of some major geological problems of Three Gorges Project

    Institute of Scientific and Technical Information of China (English)

    Chen Deji; Man Zuowu

    2011-01-01

    The research process, main contents, methods and conclusions for some major engineering geological problems of the Three Gorges Project (TGP) are reviewed and introduced, including dam site selection, regional tectonic stability and seismic activity, stability of reservoir bank and reservoir-induced earthquake. Meanwhile, the above mentioned engineering geological problems are evaluated according to the preliminary test results since TGP operation and impoundment in 2003.

  13. Are reviewers obstructing stem cell research?

    Directory of Open Access Journals (Sweden)

    Bernard Binetruy

    2010-08-01

    Full Text Available Bernard BinetruyINSERM U626, Faculté de Médecine La Timone, Marseille, FranceA current controversy in stem cell research was published on the BBC website recently. Some stem cell researchers have said that "they believe a small group of scientists is effectively vetoing high quality science from publication in journals". They strongly suspected some reviewers to be deliberately sending back negative comments or asking for unnecessary experiments. Nature editor, Dr Philip Campbell, has said that "this idea is utterly false".

  14. Updates in colorectal cancer stem cell research

    Directory of Open Access Journals (Sweden)

    Chun-Jie Li

    2014-01-01

    Full Text Available Colorectal cancer (CRC is one of the world most common malignant tumors, also is the main disease, which cause tumor-associated death. Surgery and chemotherapy are the most used treatment of CRC. Recent research reported that, cancer stem cells (CSCs are considered as the origin of tumor genesis, development, metastasis and recurrence in theory. At present, it has been proved that, CSCs existed in many tumors including CRC. In this review, we summary the identification of CSCs according to the cell surface markers, and the development of drugs that target colorectal cancer stem cells.

  15. Mixed Methods Research: The "Thing-ness" Problem.

    Science.gov (United States)

    Hesse-Biber, Sharlene

    2015-06-01

    Contemporary mixed methods research (MMR) veers away from a "loosely bounded" to a "bounded" concept that has important negative implications for how qualitatively driven mixed methods approaches are positioned in the field of mixed methods and overall innovation in the praxis of MMR. I deploy the concept of reification defined as taking an object/abstraction and treating it as if it were real such that it takes on the quality of "thing-ness," having a concrete independent existence. I argue that the contemporary reification of mixed methods as a "thing" is fueled by three interrelated factors: (a) the growing formalization of mixed methods as design, (b) the unexamined belief in the "synergy" of mixed methods and, (c) the deployment of a "practical pragmatism" as the "philosophical partner" for mixed methods inquiry. © The Author(s) 2015.

  16. Mathematical models of physics problems (physics research and technology)

    CERN Document Server

    Anchordoqui, Luis Alfredo

    2013-01-01

    This textbook is intended to provide a foundation for a one-semester introductory course on the advanced mathematical methods that form the cornerstones of the hard sciences and engineering. The work is suitable for first year graduate or advanced undergraduate students in the fields of Physics, Astronomy and Engineering. This text therefore employs a condensed narrative sufficient to prepare graduate and advanced undergraduate students for the level of mathematics expected in more advanced graduate physics courses, without too much exposition on related but non-essential material. In contrast to the two semesters traditionally devoted to mathematical methods for physicists, the material in this book has been quite distilled, making it a suitable guide for a one-semester course. The assumption is that the student, once versed in the fundamentals, can master more esoteric aspects of these topics on his or her own if and when the need arises during the course of conducting research. The book focuses on two cor...

  17. Insect cell culture in research: Indian scenario.

    Science.gov (United States)

    Sudeep, A B; Mourya, D T; Mishra, A C

    2005-06-01

    Insect cell cultures are widely used in viral diagnosis and biotechnology, for the production of recombinant proteins, viral pesticides and vaccines as well as in basic research in genetics, molecular biology, biochemistry, endocrinology and virology. Following KRP Singh's pioneering research in 1967, a large number of cell lines from diptera, hemiptera, and lepidopteran insects were established and characterized in India. With the availability of the modern tools in molecular biology and the advancements made in biotechnology, the indigenous cell lines may prove useful in creating a future without biohazardous chemical pesticides as well as producing life saving pharmaceuticals and vaccines for many diseases. This review summarizes information gathered regarding the insect cell lines established so far in India. It also covers the familiarization of the well characterized continuous cell lines and their potential applications. Special attention is given to virus susceptibility of the cell lines, the yield of virus with a comparative analysis with other conventional systems. The potential applications of dipteran and lepidopteran cell lines in agriculture and biotechnology are also briefly discussed for prospective studies.

  18. Handbook of Research on Creative Problem-Solving Skill Development in Higher Education

    DEFF Research Database (Denmark)

    Developing students’ creative problem-solving skills is paramount to today’s teachers, due to the exponentially growing demand for cognitive plasticity and critical thinking in the workforce. In today’s knowledge economy, workers must be able to participate in creative dialogue and complex problem-solving....... This has prompted institutions of higher education to implement new pedagogical methods such as problem-based and case-based education. The Handbook of Research on Creative Problem-Solving Skill Development in Higher Education is an essential, comprehensive collection of the newest research in higher...... education, creativity, problem solving, and pedagogical design. It provides the framework for further research opportunities in these dynamic, necessary fields. Featuring work regarding problem-oriented curriculum and its applications and challenges, this book is essential for policy makers, teachers...

  19. Handbook of Research on Creative Problem-Solving Skill Development in Higher Education

    DEFF Research Database (Denmark)

    Chemi, Tatiana

    2016-01-01

    Developing students’ creative problem-solving skills is paramount to today’s teachers, due to the exponentially growing demand for cognitive plasticity and critical thinking in the workforce. In today’s knowledge economy, workers must be able to participate in creative dialogue and complex problem......-solving. This has prompted institutions of higher education to implement new pedagogical methods such as problem-based and case-based education. The Handbook of Research on Creative Problem-Solving Skill Development in Higher Education is an essential, comprehensive collection of the newest research in higher...... education, creativity, problem solving, and pedagogical design. It provides the framework for further research opportunities in these dynamic, necessary fields. Featuring work regarding problem-oriented curriculum and its applications and challenges, this book is essential for policy makers, teachers...

  20. 75 FR 13137 - National Institutes of Health Guidelines for Human Stem Cell Research

    Science.gov (United States)

    2010-03-18

    ... on a revision to the definition of human embryonic stem cells (hESCs) in the ``National Institutes of Health Guidelines for Human Stem Cell Research'' (Guidelines). Due to a technical problem, comments... . Comments may also be mailed to: NIH Stem Cell Guidelines, MSC 7997, 9000 Rockville Pike, Bethesda, Maryland...

  1. Lingua-Pedagogy as the Interdisciplinary Research Problem

    Directory of Open Access Journals (Sweden)

    A. N. Yakovleva

    2012-01-01

    Full Text Available  The paper is devoted to lingua-pedagogy – one of the modern branches of pedagogy dealing with personal socialization in the process of foreign language learning. This interdisciplinary field of knowledge is related to linguistics, pedagogic psychology, development psychology and acmeology. Lingua-pedagogy undergoes the formation process; therefore, there still are a number of open questions concerning its place among the other sciences, and the final definitions of the main concepts and terms. The author recommends the systematic approach to developing the theoretical foundation of lingua- pedagogy. The paper outlines the subject and aims of the lingua-pedagogic research, its content and affecting means. The system in question is poly- functional, its main functions being the integral pedagogic effect in foreign language teaching, stimulating self-dependent learning, and arranging the in- tercultural integration. The linguistic faculties at universities can be taken as the key elements of the lingua-pedagogic system – the development centers, nurturing the value-oriented respectful attitude to the native and foreign cul- ture, providing intercultural competence acquisition, and training pedagogic staff capable of fulfilling the poly-cultural development tasks. Identification of the conformities of intercultural socialization makes it possible to organize the system of pedagogic facilitation for students learning foreign languages; and develop the perspective methods and technologies of language competence acquisition and consolidation. 

  2. The problem with pleasure: part II. The research.

    Science.gov (United States)

    Migdow, Janet

    2011-01-01

    This study explores how adult survivors of chronic abuse and neglect define pleasure, the disruption of pleasure, and the repair of the capacity for pleasure in the context of the therapeutic relationship. Using narrative methodology, I interviewed 15 clinical pairs of patients and their therapists separately. Thematic analysis revealed 8 findings. All patients reported the capacity to experience pleasure throughout life prior to therapy. Subjects defined pleasure as a variety of positive affects that fell into 2 categories: pleasure in activities and interests and pleasure in relationships. All patients reported a history of traumatic disruption of pleasure in childhood. Patients reported a history of internalizing and reenacting their own disruption of pleasure. Narratives of the patients were consistent with the narratives told by the therapists. In many clinical pairs, both parties spoke positively of an important therapeutic event when the therapist stepped out of his or her usual treatment frame. Safety, consistency, reliability, predictability, and compassionate caring were spoken of throughout the sample as elements that created a pleasurable and therapeutically reparative relationship. Patients spoke repeatedly of the importance of "finding a self" to the experience of pleasure. Pleasure enhanced the ability to find a self, and finding a self enhanced patients' capacity for pleasure. This study invites further research to investigate the function of pleasure in the process of therapeutic repair for chronically traumatized populations.

  3. What Undergraduates Misunderstand about Stem Cell Research

    Science.gov (United States)

    Halverson, Kristy Lynn; Freyermuth, Sharyn K.; Siegel, Marcelle A.; Clark, Catharine G.

    2010-01-01

    As biotechnology-related scientific advances, such as stem cell research (SCR), are increasingly permeating the popular media, it has become ever more important to understand students' ideas about this issue. Very few studies have investigated learners' ideas about biotechnology. Our study was designed to understand the types of alternative…

  4. Web Resources for Stem Cell Research

    Institute of Scientific and Technical Information of China (English)

    Ting Wei; Xing Peng; Lili Ye; Jiajia Wang; Fuhai Song; Zhouxian Bai; Guangchun Han; Fengmin Ji; Hongxing Lei

    2015-01-01

    In this short review, we have presented a brief overview on major web resources relevant to stem cell research. To facilitate more efficient use of these resources, we have provided a pre-liminary rating based on our own user experience of the overall quality for each resource. We plan to update the information on an annual basis.

  5. Medical Research on Stem Cells to Continue

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    China will maintain its opposition to human reproductive cloning but will continue to allow closely monitored embryo stem cell research for the treatment and prevention of disease, said Wang Hongguang, president of the China National Center for Biotechnology Development, on February 20 in Beijing.

  6. What Undergraduates Misunderstand about Stem Cell Research

    Science.gov (United States)

    Halverson, Kristy Lynn; Freyermuth, Sharyn K.; Siegel, Marcelle A.; Clark, Catharine G.

    2010-01-01

    As biotechnology-related scientific advances, such as stem cell research (SCR), are increasingly permeating the popular media, it has become ever more important to understand students' ideas about this issue. Very few studies have investigated learners' ideas about biotechnology. Our study was designed to understand the types of alternative…

  7. Data Linkage: A powerful research tool with potential problems

    Directory of Open Access Journals (Sweden)

    Scott Ian

    2010-12-01

    Full Text Available Abstract Background Policy makers, clinicians and researchers are demonstrating increasing interest in using data linked from multiple sources to support measurement of clinical performance and patient health outcomes. However, the utility of data linkage may be compromised by sub-optimal or incomplete linkage, leading to systematic bias. In this study, we synthesize the evidence identifying participant or population characteristics that can influence the validity and completeness of data linkage and may be associated with systematic bias in reported outcomes. Methods A narrative review, using structured search methods was undertaken. Key words "data linkage" and Mesh term "medical record linkage" were applied to Medline, EMBASE and CINAHL databases between 1991 and 2007. Abstract inclusion criteria were; the article attempted an empirical evaluation of methodological issues relating to data linkage and reported on patient characteristics, the study design included analysis of matched versus unmatched records, and the report was in English. Included articles were grouped thematically according to patient characteristics that were compared between matched and unmatched records. Results The search identified 1810 articles of which 33 (1.8% met inclusion criteria. There was marked heterogeneity in study methods and factors investigated. Characteristics that were unevenly distributed among matched and unmatched records were; age (72% of studies, sex (50% of studies, race (64% of studies, geographical/hospital site (93% of studies, socio-economic status (82% of studies and health status (72% of studies. Conclusion A number of relevant patient or population factors may be associated with incomplete data linkage resulting in systematic bias in reported clinical outcomes. Readers should consider these factors in interpreting the reported results of data linkage studies.

  8. Ethical problems inherent in psychological research based on internet communication as stored information

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter; Dyhrberg, Johan

    2007-01-01

    This paper deals with certain ethical problems inherent in psychological research based on internet communication as stored information. Section 1 contains an analysis of research on Internet debates. In particular, it takes into account a famous example of deception for psychology research...... purposes. In section 2, the focus is on research on personal data in texts published on the Internet. Section 3 includes an attempt to formulate some ethical principles and guidelines, which should be regarded as fundamental in research on stored information....

  9. Ethical problems inherent in psychological research based on internet communication as stored information

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter; Dyhrberg, Johan

    2007-01-01

    This paper deals with certain ethical problems inherent in psychological research based on internet communication as stored information. Section 1 contains an analysis of research on Internet debates. In particular, it takes into account a famous example of deception for psychology research...... purposes. In section 2, the focus is on research on personal data in texts published on the Internet. Section 3 includes an attempt to formulate some ethical principles and guidelines, which should be regarded as fundamental in research on stored information....

  10. Survey of the research on dynamic weapon-target assignment problem

    Institute of Scientific and Technical Information of China (English)

    Cai Huaiping; Liu Jingxu; Chen Yingwu; Wang Hao

    2006-01-01

    The basic concepts and models of weapon-target assignment (WTA) are introduced and the mathematical nature of the WTA models is also analyzed. A systematic survey of research on WTA problem is provided. The present research on WTA is focused on models and algorithms. In the research on models of WTA, the static WTA models are mainly studied and the dynamic WTA models are not fully studied in deed. In the research on algorithms of WTA, the intelligent algorithms are often used to solve the WTA problem. The small scale of static WTA problems has been solved very well, however, the large scale of dynamic WTA problems has not been solved effectively so far. Finally, the characteristics of dynamic WTA are analyzed and directions for the future research on dynamic WTA are discussed.

  11. The SERP Approach to Problem-Solving Research, Development, and Implementation

    Science.gov (United States)

    Donovan, M. Suzanne; Snow, Catherine; Daro, Phil

    2013-01-01

    Education researchers are increasingly working in practice-based partnerships in order to direct their research efforts toward important problems of practice. We argue for the creation of an infrastructure to support routine and sustained interaction among researchers, practitioners, and designers in order to make partnership efforts more…

  12. Final Technical Report for "Applied Mathematics Research: Simulation Based Optimization and Application to Electromagnetic Inverse Problems"

    Energy Technology Data Exchange (ETDEWEB)

    Haber, Eldad

    2014-03-17

    The focus of research was: Developing adaptive mesh for the solution of Maxwell's equations; Developing a parallel framework for time dependent inverse Maxwell's equations; Developing multilevel methods for optimization problems with inequal- ity constraints; A new inversion code for inverse Maxwell's equations in the 0th frequency (DC resistivity); A new inversion code for inverse Maxwell's equations in low frequency regime. Although the research concentrated on electromagnetic forward and in- verse problems the results of the research was applied to the problem of image registration.

  13. Adapting Cell-Based Assays to the High Throughput Screening Platform: Problems Encountered and Lessons Learned.

    Science.gov (United States)

    Maddox, Clinton B; Rasmussen, Lynn; White, E Lucile

    2008-06-01

    In recent years, cell-based phenotypic assays have emerged as an effective and robust addition to the array of assay technologies available for drug discovery in the high throughput screening arena. Previously, biochemical target-based assays have been the technology of choice. With the emergence of stem cells as a basis for a new screening technology, it is important to keep in mind the lessons that have been learned from the adaptation of existing stable cell lines onto the high throughput screening drug discovery platform, with special consideration being given to assay miniaturization, liquid handling complications and instrument-introduced artifacts. We present an overview of the problems encountered with the implementation of multiple cell-based assays at the High Throughput Screening Center at Southern Research Institute as well as empirically defined effective solutions to these problems. These include examples of artifacts induced by temperature differences throughout the screening campaign, cell plating conditions including the effect of room temperature incubation on assay consistency, DMSO carry-over, and incubator induced artifacts.

  14. 3 CFR - Guidelines for Human Stem Cell Research

    Science.gov (United States)

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Guidelines for Human Stem Cell Research Presidential Documents Other Presidential Documents Memorandum of July 30, 2009 Guidelines for Human Stem Cell Research..., scientifically worthy human stem cell research, including human embryonic stem cell research, to the extent...

  15. Key Problems in Organizing and Structuring University Research in Vietnam: The Lack of an Effective Research "Behaviour Formalization" System

    Science.gov (United States)

    Nguyen, Huong Thi Lan; Meek, Vincent Lynn

    2016-01-01

    Structure and organization seems to be at the root of many of the questions raised about institutional behaviour; however, with respect to research on university capacity building, few studies have examined research organizational problems, particularly in developing countries. This study investigates academic reactions to the structure and…

  16. European stem cell research in legal shackles.

    Science.gov (United States)

    Nielen, Myrthe G; de Vries, Sybe A; Geijsen, Niels

    2013-12-11

    Advances in stem cell biology have raised legal challenges to the patentability of stem cells and any derived technologies and processes. In 1999, Oliver Brüstle was granted a patent for the generation and therapeutic use of neural cells derived from human embryonic stem cells (hESCs). The patent was challenged and put before the European Court of Justice, which ruled that inventions involving the prior destruction of human embryos cannot be patented. The legal maneuvering around this case demonstrates that the future of stem cell-based patents in Europe remains unsettled. Furthermore, owing to the European Court's broad definition of hESC as 'any cell that is capable of commencing development into a human being,' novel technologies that could eliminate the need for hESCs, such as induced pluripotent stem cells (iPSCs), are at risk of being included under the same ruling. Advances in the in vitro development of germ cells from pluripotent stem cells may one day provide a direct developmental path from iPSC to oocyte and sperm, and, according to the European Court's reasoning, legally equate iPSCs with human embryos. In this review, we will briefly discuss the Brüstle v Greenpeace case and the implications of the European Court of Justice's ruling. We will identify potential risks for stem cell research and future therapeutics resulting from the broad legal definition of the human embryo. Finally, we will broach the current legal landscape, as this broad definition has also created great uncertainty about the status of human iPSCs.

  17. Requirements Engineering as Creative Problem Solving: A Research Agenda for Idea Finding

    OpenAIRE

    Maiden, N.; Jones, S; Karlsen, I. K.; Neill, R.; Zachos, K.; Milne, A.

    2010-01-01

    This vision paper frames requirements engineering as a creative problem solving process. Its purpose is to enable requirements researchers and practitioners to recruit relevant theories, models, techniques and tools from creative problem solving to understand and support requirements processes more effectively. It uses 4 drivers to motivate the case for requirements engineering as a creative problem solving process. It then maps established requirements activities onto one of the longest-esta...

  18. Practical problems and possible corrections of agricultural research at tertiary education institutions

    Directory of Open Access Journals (Sweden)

    J. J. Human

    1989-03-01

    Full Text Available Agricultural research at tertiary institutions is subjected to quite a few practical problems. The most important of these are time, assistance and money. Due to the relatively high lecture load of agricultural teaching staff, it is impossible for them to do any significant research without suitable assistance. The provision in this regard is however totally inadequate at the moment. Several problems arise around funding. The most important are that it is inadequate, that there is no continuity and that poor provision is being made for the creation and maintenance of a research infrastructure. Further problems highlighted are the limited availability of funds for so called “free” research and that several problems exist around all the existing financing agents.

  19. Translational research on reprogramming of somatic cells

    Institute of Scientific and Technical Information of China (English)

    Yanhua Li; Jiahui Yin; Bingbing Zhang; Ping Zhou; Bin Feng; Fangyi Zhang; Yongzhong Lin; Zhanhua Liang; Jianling Du; Minghui Lü; Tiezheng Zheng; Jie Lin; Siyu Liu; Hao Hong; Xing Meng; Dandan Xia; Yang Sun; Pan Wei; Nan Cai; Hongye Li; Shuang Wu; Hui Zhao; Changkai Sun; Yuyuan Li; Changyu Gao; Wei Li; Ye Dai; Junde Wang; Hui Zhao; Xiaoxin Tan; Lili Men; Hui Ma; Jun Xu; Xiaohan Yang; Zengchun Hu; Ling Wang; Hong Wang; Pin Sun; Huifang Guo; Guirong Song; Hui Liu1; Baoshuai Shan; Lu Han; Linlang Liang; Min Wang; Xiaochen Wang; Dan Wang; Guihua Chen; Jianting Chen; Xiangyou Sun; Jun Xue; Zhiqi Wang; Jing Wang; Yongqing Zhang; Dongfeng Cai; Mozhen Liu; Guiping Zhang; Guoming Luan; Jianli Wang; Ming Fan; Xuetao Cao; Chao Wan; Qigui Liu; Anchun Yin

    2014-01-01

    Cerebrovascular diseases,dementia,diabetes,malignant tumors and degenerative bone diseases remain high prevalence,incidence,disability and mortality rates.One important reason might be the slow or stagnated progress in translating and applying cytoprotection and cellular repair researches into clinical practice.Based on collaboration among biomedical re-searchers,database experts,computer programmers,statisticians and management engineers,this is the first study to apply quanti-tative comparison on the overall characteristics and partial correlation analysis on the large-scale complex information and data regarding the topic“mature cells can be reprogrammed to become pluripotent”proposed by Sir John B.Gurdon and Shinya Yamanaka who were jointly awarded with 2012 Nobel Prize in Physiology or Medicine,as well as articles that cited publications of the two Nobel Laureates to discuss the prospects of translating somatic cell reprogramming researches into clinical practice and cor-responding implementation strategies.The study found that there was statistically significant difference between the two Nobel Laureates with regard to the number,publication date,subject categories and scientific and technological focuses of their origi-nal researches.The study revealed the importance,objectives,approaches and research trends of translational medicine,especially translational neuroscience.The study also identified the challenges that China should overcome to improve its medical research management scheme.

  20. The Problem of Empirical Redundancy of Constructs in Organizational Research: An Empirical Investigation

    Science.gov (United States)

    Le, Huy; Schmidt, Frank L.; Harter, James K.; Lauver, Kristy J.

    2010-01-01

    Construct empirical redundancy may be a major problem in organizational research today. In this paper, we explain and empirically illustrate a method for investigating this potential problem. We applied the method to examine the empirical redundancy of job satisfaction (JS) and organizational commitment (OC), two well-established organizational…

  1. Future Directions for Research on the Development and Prevention of Early Conduct Problems

    Science.gov (United States)

    Shaw, Daniel S.

    2013-01-01

    This article describes our state of knowledge regarding the development and prevention of conduct problems in early childhood, then identifies directions that would benefit future basic and applied research. Our understanding about the course and risk factors associated with early-developing conduct problems has been significantly enhanced during…

  2. The Problem of Empirical Redundancy of Constructs in Organizational Research: An Empirical Investigation

    Science.gov (United States)

    Le, Huy; Schmidt, Frank L.; Harter, James K.; Lauver, Kristy J.

    2010-01-01

    Construct empirical redundancy may be a major problem in organizational research today. In this paper, we explain and empirically illustrate a method for investigating this potential problem. We applied the method to examine the empirical redundancy of job satisfaction (JS) and organizational commitment (OC), two well-established organizational…

  3. Impact of problem finding on the quality of authentic open inquiry science research projects

    Science.gov (United States)

    Labanca, Frank

    2008-11-01

    Problem finding is a creative process whereby individuals develop original ideas for study. Secondary science students who successfully participate in authentic, novel, open inquiry studies must engage in problem finding to determine viable and suitable topics. This study examined problem finding strategies employed by students who successfully completed and presented the results of their open inquiry research at the 2007 Connecticut Science Fair and the 2007 International Science and Engineering Fair. A multicase qualitative study was framed through the lenses of creativity, inquiry strategies, and situated cognition learning theory. Data were triangulated by methods (interviews, document analysis, surveys) and sources (students, teachers, mentors, fair directors, documents). The data demonstrated that the quality of student projects was directly impacted by the quality of their problem finding. Effective problem finding was a result of students using resources from previous, specialized experiences. They had a positive self-concept and a temperament for both the creative and logical perspectives of science research. Successful problem finding was derived from an idiosyncratic, nonlinear, and flexible use and understanding of inquiry. Finally, problem finding was influenced and assisted by the community of practicing scientists, with whom the students had an exceptional ability to communicate effectively. As a result, there appears to be a juxtaposition of creative and logical/analytical thought for open inquiry that may not be present in other forms of inquiry. Instructional strategies are suggested for teachers of science research students to improve the quality of problem finding for their students and their subsequent research projects.

  4. Dye solar cell research: EU delegation presentation

    CSIR Research Space (South Africa)

    Cummings, F

    2009-11-09

    Full Text Available stream_source_info Cummings1_2009.pdf.txt stream_content_type text/plain stream_size 3236 Content-Encoding UTF-8 stream_name Cummings1_2009.pdf.txt Content-Type text/plain; charset=UTF-8 DYE SOLAR CELL RESEARCH... Franscious Cummings Energy and Processes Materials Science and Manufacturing Council for Scientific and Industrial Research P.O. Box 395 Pretoria 0001, South Africa 13 November 2009 © CSIR 2007 www.csir.co.za CONTENT head2right...

  5. Automated solar cell assembly team process research

    Science.gov (United States)

    Nowlan, M. J.; Hogan, S. J.; Darkazalli, G.; Breen, W. F.; Murach, J. M.; Sutherland, S. F.; Patterson, J. S.

    1994-06-01

    This report describes work done under the Photovoltaic Manufacturing Technology (PVMaT) project, Phase 3A, which addresses problems that are generic to the photovoltaic (PV) industry. Spire's objective during Phase 3A was to use its light soldering technology and experience to design and fabricate solar cell tabbing and interconnecting equipment to develop new, high-yield, high-throughput, fully automated processes for tabbing and interconnecting thin cells. Areas that were addressed include processing rates, process control, yield, throughput, material utilization efficiency, and increased use of automation. Spire teamed with Solec International, a PV module manufacturer, and the University of Massachusetts at Lowell's Center for Productivity Enhancement (CPE), automation specialists, who are lower-tier subcontractors. A number of other PV manufacturers, including Siemens Solar, Mobil Solar, Solar Web, and Texas instruments, agreed to evaluate the processes developed under this program.

  6. Research on magnetic metallization of bacterial cells

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    A multidisciplinary approach to the fabrication of biologically based magnetic monomers for biolimited forming is described. Rod-like Bacilli cereus about 0.5 μm in diameter and 3-5 μm in length, were used as templates on which the ferromagnetic material was deposited by an electroless deposition method. Different electroless plating solutions were compared in detail and CoNiP solution was selected. During the deposition process, both dispersant and mechanical stirring were used to solve the problem of aggregation of bacterial cells so as to obtain a uniform plating layer. The CoNiP film on Bacilli cereus was a mixture of crystalline and non-crystalline in the phase structure and showed a good magnetism. The magnetic metallized bacterial cells could be manipulated with a magnetic field. Parallel arrays of these micro magnetic particles were achieved and they could rotate along with the magnetic field.

  7. Problems

    Directory of Open Access Journals (Sweden)

    Yekini Shehu

    2010-01-01

    real Banach space which is also uniformly smooth using the properties of generalized f-projection operator. Using this result, we discuss strong convergence theorem concerning general H-monotone mappings and system of generalized mixed equilibrium problems in Banach spaces. Our results extend many known recent results in the literature.

  8. Review of Problems in Research of Individual Differences in Second Language Acquisition

    Institute of Scientific and Technical Information of China (English)

    LIU Fei

    2015-01-01

    Although research on individual differences became the mainstream in SLA, it still obviously lag behind research on similarities over the whole. In order to find a clear developing direction for research in this field, main problems and difficulties arose in earlier research will be discussed. Suggestions and prospects for research on individual differences of SLA will be also pro⁃posed. The ideal of modifying one’s way of teaching to suit the special requirements of each class or case should be the main trend of research on individual differences of SLA.

  9. A review of three decades of research on some combinatorial optimization problems

    Directory of Open Access Journals (Sweden)

    Horacio Hideki Yanasse

    2013-04-01

    Full Text Available This paper presents an overview of our research in combinatorial optimization problems. Over the last three decades, our team has been studying mostly optimization problems that arise in industrial environments through the elaboration and solution of mathematical decision models. In addition to elaborating innovative models, we have improved upon existing solutions to complex problems, helping decision makers and researchers to better understand complex industrial systems. Our work has focused on the development of computationally more efficient algorithms that improve on existing methods by improving the solution quality or reducing the computation effort to obtain good solutions. While some of our earlier work became less necessary with the speed up of the computational facilities, the search for improved solution quality and reduced computational effort continues. After reviewing our findings on lot sizing, production scheduling, cutting problems, pattern sequencing, tool switches in flexible manufacturing machines and integrated cutting and sequencing problems, we propose topics for future study.

  10. Efficient Parallel Sorting for Migrating Birds Optimization When Solving Machine-Part Cell Formation Problems

    OpenAIRE

    Ricardo Soto; Broderick Crawford; Boris Almonacid; Fernando Paredes

    2016-01-01

    The Machine-Part Cell Formation Problem (MPCFP) is a NP-Hard optimization problem that consists in grouping machines and parts in a set of cells, so that each cell can operate independently and the intercell movements are minimized. This problem has largely been tackled in the literature by using different techniques ranging from classic methods such as linear programming to more modern nature-inspired metaheuristics. In this paper, we present an efficient parallel version of the Migrating Bi...

  11. TRANSPARENT COATINGS FOR SOLAR CELLS RESEARCH

    Energy Technology Data Exchange (ETDEWEB)

    Glatkowski, P. J.; Landis, D. A.

    2013-04-16

    Todays solar cells are fabricated using metal oxide based transparent conductive coatings (TCC) or metal wires with optoelectronic performance exceeding that currently possible with Carbon Nanotube (CNT) based TCCs. The motivation for replacing current TCC is their inherent brittleness, high deposition cost, and high deposition temperatures; leading to reduced performance on thin substrates. With improved processing, application and characterization techniques Nanofiber and/or CNT based TCCs can overcome these shortcomings while offering the ability to be applied in atmospheric conditions using low cost coating processes At todays level of development, CNT based TCC are nearing commercial use in touch screens, some types of information displays (i.e. electronic paper), and certain military applications. However, the resistivity and transparency requirements for use in current commercial solar cells are more stringent than in many of these applications. Therefore, significant research on fundamental nanotube composition, dispersion and deposition are required to reach the required performance commanded by photovoltaic devices. The objective of this project was to research and develop transparent conductive coatings based on novel nanomaterial composite coatings, which comprise nanotubes, nanofibers, and other nanostructured materials along with binder materials. One objective was to show that these new nanomaterials perform at an electrical resistivity and optical transparency suitable for use in solar cells and other energy-related applications. A second objective was to generate new structures and chemistries with improved resistivity and transparency performance. The materials also included the binders and surface treatments that facilitate the utility of the electrically conductive portion of these composites in solar photovoltaic devices. Performance enhancement venues included: CNT purification and metallic tube separation techniques, chemical doping, CNT

  12. Building pathology in the Netherlands – main problems and results through research and practice.

    NARCIS (Netherlands)

    Thomsen, A.F.

    2014-01-01

    This report is dedicated to the main problems of building pathologies in the Netherlands and the main solutions through research and practice as questioned by the CIB W086 Building Pathology Commission for its 2014 meeting in Sao Paulo, Brazil. Objective is to contribute to the Research Roadmap 2014

  13. New paradigms for old problems: some (small) advances in laser resonator research at the CSIR

    Science.gov (United States)

    Forbes, Andrew

    2010-02-01

    In this paper we outline new approaches to old problems, namely understanding the transverse modes in Porro prism resonators, and creating methods to select Gaussian beams by phase-only intra-cavity elements. In the process we outline some of the recent research that has taken place within the Mathematical Optics research group.

  14. Constructing Transformative Experiences through Problem Posing in a High School English Research Project

    Science.gov (United States)

    Revelle, Carol L.

    2009-01-01

    This dissertation chronicles my search to engage high school English students in inquiry as part of a formal research process. The perspective of critical literacy theory is used to describe the four phases of the problem posing process in shaping student research and action. Grounded in Freire's approach and consistent with Dewey and others who…

  15. OPERATIONS-RESEARCH AS A TOOL FOR ANALYSIS OF FOOD SECURITY PROBLEMS

    NARCIS (Netherlands)

    SCHWEIGMAN, C; BAKKER, EJ; SNIJDERS, TAB

    1990-01-01

    In the first part of the paper the role of operations research in analyzing daily life problems of farmers in developing countries is discussed. Experiences on village studies in Tanzania are reported which formed part of the training in operations research of students of the University of Dar es

  16. Scientific Paradigms and Falsification: Kuhn, Popper, and Problems in Education Research

    Science.gov (United States)

    Hyslop-Margison, Emery James

    2010-01-01

    By examining the respective contributions of Karl Popper and Thomas Kuhn to the philosophy of science, the author highlights some prevailing problems in this article with the methods of so-called scientific research in education. The author enumerates a number of reasons why such research, in spite of its limited tangible return, continues to gain…

  17. Discarded leukoreduction filters: a new source of stem cells for research, cell engineering and therapy?

    Science.gov (United States)

    Peytour, Yann; Villacreces, Arnaud; Chevaleyre, Jean; Ivanovic, Zoran; Praloran, Vincent

    2013-09-01

    New adult stem cell sources, devoid of the technical/ethical/economical barriers of those presently available, would favor the ongoing development of in vitro cell engineering and transplantation. Hematopoietic transplantation opened the way to and remains the most successful cell transplantation procedure. CD34+ cells that include hematopoietic stem cells (HSCs) and hematopoietic progenitors (HPs) are presently harvested from bone marrow (BM), cord blood or peripheral blood (after being mobilized from BM). The panel of potential donors, the quantities of collected cells and some other technical/medical problems still represent limiting factors to their transplantation in some patients. Steady state peripheral blood (SSPB) contains very low frequencies of CD34+ cells. They are trapped in leukoreduction filters (LRFs), which are discarded after the preparation of therapeutic red blood cell concentrates from individual blood donations. We recently developed a procedure allowing the easy and rapid elution of CD34+ cells from LRFs and we showed that they are functionally similar to those harvested from other sources. After providing an overview of the sources, interests and limitations of therapeutic HSCs presently available, we will provide arguments based on our and others' results suggesting that SSPB could become an attractive source of HSCs for hematopoietic transplantation and of other cell types for various research/development procedures.

  18. A facility for using cluster research to study environmental problems. Workshop proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This report begins by describing the general application of cluster based research to environmental chemistry and the development of a Cluster Structure and Dynamics Research Facility (CSDRF). Next, four important areas of cluster research are described in more detail, including how they can impact environmental problems. These are: surface-supported clusters, water and contaminant interactions, time-resolved dynamic studies in clusters, and cluster structures and reactions. These facilities and equipment required for each area of research are then presented. The appendices contain workshop agenda and a listing of the researchers who participated in the workshop discussions that led to this report.

  19. Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.

    Science.gov (United States)

    Smith, Rosanna C G; Stumpf, Patrick S; Ridden, Sonya J; Sim, Aaron; Filippi, Sarah; Harrington, Heather A; MacArthur, Ben D

    2017-06-20

    A number of important pluripotency regulators, including the transcription factor Nanog, are observed to fluctuate stochastically in individual embryonic stem cells. By transiently priming cells for commitment to different lineages, these fluctuations are thought to be important to the maintenance of, and exit from, pluripotency. However, because temporal changes in intracellular protein abundances cannot be measured directly in live cells, fluctuations are typically assessed using genetically engineered reporter cell lines that produce a fluorescent signal as a proxy for protein expression. Here, using a combination of mathematical modeling and experiment, we show that there are unforeseen ways in which widely used reporter strategies can systematically disturb the dynamics they are intended to monitor, sometimes giving profoundly misleading results. In the case of Nanog, we show how genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type. These findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  20. Mixed-Method Nursing Research: "A Public and Its Problems?" A Commentary on French Nursing Research.

    Science.gov (United States)

    Dupin, Cécile Marie; Debout, Christophe; Rothan-Tondeur, Monique

    2014-02-01

    Nursing in France is undergoing a transition. In 2009, the preregistration nursing education program was reformed in line with the European Bologna Process, bringing nursing education to the universities. In 2010, the French Programme Hospitalier de Recherche Infirmière, the first national French nursing research funding program, was launched by the French Health Ministry. Of the 149 French research proposals submitted by registered nurses in 2010 and 2011, 13 were mixed-method proposals. The registered nurse principal investigator argued for a complementary use of qualitative and quantitative methods. These trends highlight major issues regarding mixed-method and nursing research. We can reasonably assume that mixed-method research has a broad appeal for nurse scholars, particularly for the exploration of complex phenomena related to nursing. Moreover, the recent movement in the domain of nursing education and research experienced in France highlights the need for dedicated research education in the development of nursing research capacity. © The Author(s) 2014 Reprints and permissions:]br]sagepub.co.uk/journalsPermissions.nav.

  1. Intermodal safety research needs report of the sixth workshop on national transportation problems

    Energy Technology Data Exchange (ETDEWEB)

    Warshawer, A.J. (ed.)

    1976-04-01

    This conference brought together DOT policymakers, university principal investigators and other professionals to consider the intermodal safety research requirements of the Department of Transportation. The objectives of the conference were: (1) to highlight safety problems and needed transportation safety research identified by DOT modal safety managers and to stimulate university or university/industry teams to respond with research proposals which emphasize multi-modal applicability and a system view; and (2) to provide a forum for university research groups to inform DOT safety managers of promising new directions in transportation safety research and new tools with which to address safety related problems. The conference addressed the research requirements for safety as identified by the Statement of National Transportation Policy and by the modal safety managers in three principal contexts, each a workshop panel: I, Inter-Institutional Problems of Transportation Safety. Problems were described as: Federal-State, local; Federal-Industry; Federal-Public, Consumer groups. II, Goal Setting and Planning for Transportation Safety Programs. Issues were: modifying risk behavior, safety as a social value, and involving citizens in development of standards as a way of increasing probability of achieving program objectives. III, DOT Information, Management, and Evaluation Systems Requirements. Needs were: data requirements and analytic tools for management of safety programs.

  2. Language and rigour in qualitative research: problems and principles in analyzing data collected in Mandarin.

    Science.gov (United States)

    Smith, Helen J; Chen, Jing; Liu, Xiaoyun

    2008-07-10

    In collaborative qualitative research in Asia, data are usually collected in the national language, and this poses challenges for analysis. Translation of transcripts to a language common to the whole research team is time consuming and expensive; meaning can easily be lost in translation; and validity of the data may be compromised in this process. We draw on several published examples from public health research conducted in mainland China, to highlight how language can influence rigour in the qualitative research process; for each problem we suggest potential solutions based on the methods used in one of our research projects in China. Problems we have encountered include obtaining sufficient depth and detail in qualitative data; deciding on language for data collection; managing data collected in Mandarin; and the influence of language on interpreting meaning. We have suggested methods for overcoming problems associated with collecting, analysing, and interpreting qualitative data in a local language, that we think help maintain analytical openness in collaborative qualitative research. We developed these methods specifically in research conducted in Mandarin in mainland China; but they need further testing in other countries with data collected in other languages. Examples from other researchers are needed.

  3. Estimating Rates of Psychosocial Problems in Urban and Poor Children with Sickle Cell Anemia.

    Science.gov (United States)

    Barbarin, Oscar A.; And Others

    1994-01-01

    Examined adjustment problems for children and adolescents with sickle cell anemia (SCA). Parents provided information on social, emotional, academic, and family adjustment of 327 children with SCA. Over 25% of children had emotional adjustment problems in form of internalizing symptoms (anxiety and depression); at least 20% had problems related to…

  4. Estimating Rates of Psychosocial Problems in Urban and Poor Children with Sickle Cell Anemia.

    Science.gov (United States)

    Barbarin, Oscar A.; And Others

    1994-01-01

    Examined adjustment problems for children and adolescents with sickle cell anemia (SCA). Parents provided information on social, emotional, academic, and family adjustment of 327 children with SCA. Over 25% of children had emotional adjustment problems in form of internalizing symptoms (anxiety and depression); at least 20% had problems related to…

  5. How can we improve problem-solving in undergraduate biology? Applying lessons from 30 years of physics education research

    CERN Document Server

    Hoskinson, Anne-Marie; Knight, Jennifer K

    2012-01-01

    Modern biological problems are complex. If students are to successfully grapple with such problems as scientists and citizens, they need to have practiced solving authentic, complex problems during their undergraduate years. Physics education researchers have investigated student problem-solving for the last three decades. Although the surface features and content of biology problems differ from physics problems, teachers of both sciences want students to learn to explain patterns and processes in the natural world and to make predictions about system behaviors. After surveying literature on problem-solving in physics and biology, we propose how biology education researchers could apply research-supported pedagogical techniques from physics to enhance biology students' problem-solving. First, we characterize the problems that biology students are typically asked to solve. We then describe the development of research-validated physics problem-solving curricula. Finally, we propose how biology scholars can appl...

  6. Major research approaches to solve gas-dynamic problems in Donbass coal mines

    Energy Technology Data Exchange (ETDEWEB)

    Kuzyara, V.I.; Agaphonov, A.V. [Makeyevka State Safety in Mine Research Institute, Makeyevka (Ukraine)

    1997-12-31

    The number of gas-dynamic events per million tons of coal mined remains great though coal output from underground coal mines in Donetsk basin has dropped. This dictates enhanced research efforts to solve the following gas-dynamic problems: sudden coal, rock and gas outbursts, sudden coal, rock and gas outbursts, sudden squeezing, falls (coal spillage) sudden methane inrushes from the bottom, and bumps. New approaches to solve these problems have been based on modern concepts and ideas of natural mechanisms of the events. Current and future research needs are discussed. 7 refs., 3 figs., 2 tabs.

  7. Ground Zero in the Debate over Stem-Cell Research.

    Science.gov (United States)

    Southwick, Ron

    2001-01-01

    Describes how political, legal, and ethical battles over embryonic stem-cell research are focused on the University of Wisconsin at Madison, where the cells were first isolated. Addresses the issue of access to the university's stem cells and a recent presidential decision regarding funding for stem-cell research.(EV)

  8. Ground Zero in the Debate over Stem-Cell Research.

    Science.gov (United States)

    Southwick, Ron

    2001-01-01

    Describes how political, legal, and ethical battles over embryonic stem-cell research are focused on the University of Wisconsin at Madison, where the cells were first isolated. Addresses the issue of access to the university's stem cells and a recent presidential decision regarding funding for stem-cell research.(EV)

  9. Radiolabeled red blood cells: status, problems, and prospects

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, S.C.

    1983-01-01

    Radionuclidic labels for red cells can be divided into two main categories - cohort or pulse labels, and random labels. The random labels are incorporated into circulating cells of all ages and the labeling process is usually carried out in vitro. The red cell labels in predominant use involve random labeling and employ technetium-99m, chromium-51, indium-111, and gallium-68, roughly in that order. The extent of usefulness depends on the properties of the label such as the half-life, decay mode, and in-vivo stability, etc. Labeled cells can be used for red cell survival measurements when the half-life of the radionuclide is sufficiently long. The major portion of this article deals with random labels.

  10. Gordon Memorial Lecture. Problems and crusades: a history of poultry disease research in the United Kingdom.

    Science.gov (United States)

    Payne, L N

    1994-03-01

    1. Poultry disease research in the UK began recognisably in the 1920s, in consequence of the development of a national poultry industry of economic importance. 2. Increasing disease problems during the 1930s revealed the need for more research, resulting notably in the growth of the Poultry Department of the Central Veterinary Laboratory and the establishment of Houghton Poultry Research Station. 3. Continued growth of the egg industry and the introduction of the broiler industry in the 1950s stimulated increased disease research, much of it publicly funded, during the following two decades. 4. Changing government attitudes to agricultural research in the 1980s brought about far-reaching changes to the funding, organisation, nature and amount of disease research conducted. Arrangements for such research continue to evolve.

  11. Stem cells for cardiac repair: problems and possibilities.

    Science.gov (United States)

    Henning, Robert J

    2013-11-01

    Ischemic heart disease is a major cause of death throughout the world. In order to limit myocardial damage and possibly generate new myocardium, stem cells are currently being injected into patients with ischemic heart disease. Three major patient investigations, The LateTIME, the TIME and the Swiss Myocardial Infarction trials, have recently addressed the questions of whether progenitor cells from unfractionated bone marrow mononuclear cells limit myocardial damage and what the optimal time to inject these cells after acute myocardial infarctions (AMIs) is. In each of these trials, there were no significant differences between treated and control patients when bone marrow cells were administered 5-7 days or 2-3 weeks after AMIs. Nevertheless, these investigations provide important information regarding clinical trial designs. Patients with AMIs in these trials were treated with percutaneous coronary intervention within a median of 4-5 h after the onset of chest pain. Thereafter, all patients received guideline-guided optimal medical therapy. Consequently, the sizes of AMIs were significantly limited. In patients with small AMIs and near-normal left ventricular ejection fractions, progenitor cells are least effective. However, these trials do question whether autologous bone marrow mononuclear cells are the optimal cells for myocardial repair owing to low numbers of progenitor cells in bone marrow aspirates and the significant variability in potency and efficacy of these cells in patients with chronic multisystem diseases. In contrast, the SCIPIO and the CAUDUCEUS trials examined cardiac progenitor cells in patients with ischemic cardiomyopathies. These trials reported over 1-2 years that cardiac progenitor cells produced significant improvements in left ventricular contractility due to 12-24 g decreases in myocardial scars and 18-23 g increases in viable myocardial muscle. However, caution must be exercised in the interpretation of these studies due to the small

  12. International Research Workshop on Integrating GIS and Environmental Modeling: Problems, Prospects, and Research Needs

    Science.gov (United States)

    Parks, Bradley

    2001-01-01

    The 4th International Conference on Integrating GIS and Environmental Modeling (GIS/EM4) was convened in Banff, Canada, September 2-8, 2000 at The Banff Centre for Conferences. The meeting's purpose, like it's predecessors was to reformulate, each three to four years, the collaborative research agenda for integrating spatio-temporal analysis with environmental simulation modeling.

  13. Sourcing human embryos for embryonic stem cell lines: Problems & perspectives

    OpenAIRE

    Mehta, Rajvi H.

    2014-01-01

    The ability to successfully derive human embryonic stem cells (hESC) lines from human embryos following in vitro fertilization (IVF) opened up a plethora of potential applications of this technique. These cell lines could have been successfully used to increase our understanding of human developmental biology, transplantation medicine and the emerging science of regenerative medicine. The main source for human embryos has been ′discarded′ or ′spare′ fresh or frozen human embryos following IVF...

  14. MULTICRITERIA HYBRID FLOW SHOP SCHEDULING PROBLEM: LITERATURE REVIEW, ANALYSIS, AND FUTURE RESEARCH

    Directory of Open Access Journals (Sweden)

    Marcia de Fatima Morais

    2014-12-01

    Full Text Available This research focuses on the Hybrid Flow Shop production scheduling problem, which is one of the most difficult problems to solve. The literature points to several studies that focus the Hybrid Flow Shop scheduling problem with monocriteria functions. Despite of the fact that, many real world problems involve several objective functions, they can often compete and conflict, leading researchers to concentrate direct their efforts on the development of methods that take consider this variant into consideration. The goal of the study is to review and analyze the methods in order to solve the Hybrid Flow Shop production scheduling problem with multicriteria functions in the literature. The analyses were performed using several papers that have been published over the years, also the parallel machines types, the approach used to develop solution methods, the type of method develop, the objective function, the performance criterion adopted, and the additional constraints considered. The results of the reviewing and analysis of 46 papers showed opportunities for future research on this topic, including the following: (i use uniform and dedicated parallel machines, (ii use exact and metaheuristics approaches, (iv develop lower and uppers bounds, relations of dominance and different search strategies to improve the computational time of the exact methods,  (v develop  other types of metaheuristic, (vi work with anticipatory setups, and (vii add constraints faced by the production systems itself.

  15. Means-end chains and laddering: An inventory of problems and an agenda for research

    DEFF Research Database (Denmark)

    Grunert, Klaus G.; Beckmann, Suzanne C.; Sørensen, Elin

    2001-01-01

    and unconscious (or, at least, semiconscious) factors. It is intuitively appealing to the practitioner but has, likewise, attracted academic research. Increased acceptance and use of a new approach inevitably leads to the detection of unresolved issues and problems. Many of these unresolved issues are related...

  16. Research on the Problem of Spur Gear Teeth Contact in the Car Gear Box

    Directory of Open Access Journals (Sweden)

    Viktor Skrickij

    2011-04-01

    Full Text Available The article presents research on the problem of two gear contact in the car gearbox. Contact stiffness is evaluated for the whole period of mesh. Also, contact stresses are evaluated in the contact place. The presented method can be used for calculating spur gear.Article in Lithuanian

  17. Factors Affecting the Identification of Research Problems in Educational Administration Studies

    Science.gov (United States)

    Yalçin, Mikail; Bektas, Fatih; Öztekin, Özge; Karadag, Engin

    2016-01-01

    The purpose of this study is to reveal the factors that affect the identification of research problems in educational administration studies. The study was designed using the case study method. Criterion sampling was used to determine the work group; the criterion used to select the participants was that of having a study in the field of…

  18. Research on sub-Saharan Africa's unrecorded international trade : some methodological and conceptual problems

    NARCIS (Netherlands)

    Ellis, S.D.K.; MacGaffey, Janet

    1996-01-01

    This paper describes some of the methodological and conceptual problems in researching aspects of sub-Saharan Africa's international 'underground' trade, meaning commercial transactions which are conducted across international frontiers but which are unrecorded in official data. The authors focus in

  19. Hierarchical Multiple Regression in Counseling Research: Common Problems and Possible Remedies.

    Science.gov (United States)

    Petrocelli, John V.

    2003-01-01

    A brief content analysis was conducted on the use of hierarchical regression in counseling research published in the "Journal of Counseling Psychology" and the "Journal of Counseling & Development" during the years 1997-2001. Common problems are cited and possible remedies are described. (Contains 43 references and 3 tables.) (Author)

  20. Ten-Year Research Update Review: Psychiatric Problems in Children with Epilepsy

    Science.gov (United States)

    Plioplys, Sigita; Dunn, David W.; Caplan, Rochelle

    2007-01-01

    The research on epilepsy, a neuropsychiatric disorder characterized by seizures, psychopathology, cognitive, and linguistic problems among children in the age group of 0 to 18 years is reported. Early identification of children with epilepsy (CWE) and the development of multidisciplinary management strategies would advance relevant clinical…

  1. Scaffolding the Science: Problem Based Strategies for Teaching Interdisciplinary Undergraduate Research Methods

    Science.gov (United States)

    Keebaugh, Alaine; Darrow, Lyndsey; Tan, David; Jamerson, Heather

    2009-01-01

    Previous research has highlighted the effectiveness of Problem-Based Learning (PBL) in multiple disciplinary settings, including medicine, teacher education, business, allied health, and the social sciences. Yet interdisciplinary educators have very little information about how to implement PBL in classrooms where multiple disciplines are…

  2. Research Progress of Nuclear Astrophysics Physics:Study of Key Scientific Problems in Nuclear Synthesis

    Institute of Scientific and Technical Information of China (English)

    GUO; Bing; LIU; Wei-ping; LI; Zhi-hong; WANG; You-bao; HE; Jian-jun; SHI; Jian-rong; TANG; Xiao-dong; YAN; Sheng-quan; SU; Jun; LI; Yun-ju; ZENG; Sheng; LIAN; Gang; BAI; Xi-xiang; CHEN; Yong-shou; PANG; Dan-yang; GU; Jian-zhong; HAN; Zhi-yu; LI; Xin-yue

    2015-01-01

    1 Summary A systematic study of the key scientific problems in nuclear synthesis has been conducted.Significant research achievements from several important subjects such as direct measurement of astrophysical reaction,observation of abundances of elements,studies on decay properties of nuclei and reaction rates of primordial nucleosynthesis have been made utilizing large scientific facilities from China

  3. Competitive Benchmarking: An IS Research Approach to Address Wicked Problems with Big Data and Analytics

    NARCIS (Netherlands)

    W. Ketter (Wolfgang); M. Peters (Markus); J. Collins (John); A. Gupta (Alok)

    2015-01-01

    textabstractWicked problems like sustainable energy and financial market stability are societal challenges that arise from complex socio-technical systems in which numerous social, economic, political, and technical factors interact. Understanding and mitigating them requires research methods that s

  4. Solving problems in social-ecological systems: definition, practice and barriers of transdisciplinary research.

    Science.gov (United States)

    Angelstam, Per; Andersson, Kjell; Annerstedt, Matilda; Axelsson, Robert; Elbakidze, Marine; Garrido, Pablo; Grahn, Patrik; Jönsson, K Ingemar; Pedersen, Simen; Schlyter, Peter; Skärbäck, Erik; Smith, Mike; Stjernquist, Ingrid

    2013-03-01

    Translating policies about sustainable development as a social process and sustainability outcomes into the real world of social-ecological systems involves several challenges. Hence, research policies advocate improved innovative problem-solving capacity. One approach is transdisciplinary research that integrates research disciplines, as well as researchers and practitioners. Drawing upon 14 experiences of problem-solving, we used group modeling to map perceived barriers and bridges for researchers' and practitioners' joint knowledge production and learning towards transdisciplinary research. The analysis indicated that the transdisciplinary research process is influenced by (1) the amount of traditional disciplinary formal and informal control, (2) adaptation of project applications to fill the transdisciplinary research agenda, (3) stakeholder participation, and (4) functional team building/development based on self-reflection and experienced leadership. Focusing on implementation of green infrastructure policy as a common denominator for the delivery of ecosystem services and human well-being, we discuss how to diagnose social-ecological systems, and use knowledge production and collaborative learning as treatments.

  5. An Exploratory Research on Deviant Behaviors of Problem Patrons in Taiwan’s Public Library

    Directory of Open Access Journals (Sweden)

    Chen Su-May Sheih

    2016-11-01

    Full Text Available Patrons of public libraries are more diverse and complex than those of other types of libraries, implying potentially more unexpected and difficult situations. Negative emotions such as frustration and anxiety are generated among librarians when they must handle problem patrons, an effort that may influence the work efficiency of librarians and their physical and mental health. This study conducted a semi-structured in-depth interview, using public service librarians in Taiwan as subjects, to explore the categories of problem patrons and their behavioral characteristics. According to the results, the behavioral characteristics of problem patrons can be divided into 6 categories: interfering with others, violating library regulations, influencing library works, improperly using resources and facilities, breaking laws, and exhibiting a psychological disorder as well as violating social norms. On the basis of the research results, this study offers suggestions for future reference when public libraries must handle problem patrons.

  6. The cell method for electrical engineering and multiphysics problems an introduction

    CERN Document Server

    Alotto, Piergiorgio; Repetto, Maurizio; Rosso, Carlo

    2013-01-01

    This book presents a numerical scheme for the solution of field problems governed by partial differential equations: the cell method. The technique lends itself naturally to the solution of multiphysics problems with several interacting phenomena. The Cell Method, based on a space-time tessellation, is intimately related to the work of Tonti and to his ideas of classification diagrams or, as they are nowadays called, Tonti diagrams: a graphical representation of the problem's equations made possible by a suitable selection of a space-time framework relating physical variables to each other. The main features of the cell method are presented and links with many other discrete numerical methods (finite integration techniques, finite difference time domain, finite volumes, mimetic finite differences, etc.) are discussed. After outlining the theoretical basis of the method, a set of physical problems which have been solved with the cell method is described. These single and multiphysics problems stem from the aut...

  7. Assessing corrosion problems in photovoltaic cells via electrochemical stress testing

    Science.gov (United States)

    Shalaby, H.

    1985-01-01

    A series of accelerated electrochemical experiments to study the degradation properties of polyvinylbutyral-encapsulated silicon solar cells has been carried out. The cells' electrical performance with silk screen-silver and nickel-solder contacts was evaluated. The degradation mechanism was shown to be electrochemical corrosion of the cell contacts; metallization elements migrate into the encapsulating material, which acts as an ionic conducting medium. The corrosion products form a conductive path which results in a gradual loss of the insulation characteristics of the encapsulant. The precipitation of corrosion products in the encapsulant also contributes to its discoloration which in turn leads to a reduction in its transparency and the consequent optical loss. Delamination of the encapsulating layers could be attributed to electrochemical gas evolution reactions. The usefulness of the testing technique in qualitatively establishing a reliability difference between metallizations and antireflection coating types is demonstrated.

  8. Mexico City air quality research initiative. Volume 2, Problem definition, background, and summary of prior research

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    Air pollution in Mexico City has increased along with the growth of the city, the movement of its population, and the growth of employment created by industry. The main cause of pollution in the city is energy consumption. Therefore, it is necessary to take into account the city`s economic development and its prospects when considering the technological relationships between well-being and energy consumption. Air pollution in the city from dust and other particles suspended in the air is an old problem. However, pollution as we know it today began about 50 years ago with the growth of industry, transportation, and population. The level of well-being attained in Mexico City implies a high energy use that necessarily affects the valley`s natural air quality. However, the pollution has grown so fast that the City must act urgently on three fronts: first, following a comprehensive strategy, transform the economic foundation of the city with nonpolluting activities to replace the old industries, second, halt pollution growth through the development of better technologies; and third, use better fuels, emission controls, and protection of wooded areas.

  9. Problems in Using Diagnosis in Child and Adolescent Mental Health Services Research

    Directory of Open Access Journals (Sweden)

    Leonard Bickman

    2012-10-01

    Full Text Available This paper presents results from a three-part study on diagnosis of children with affective and behavior disorders. We examined the reliability, discriminant, and predictive validity of common diagnoses used in mental health services research using a research diagnostic interview. Results suggest four problems: a some diagnoses demonstrate internal consistency only slightly better than symptoms chosen at random; b diagnosis did not add appreciably to a brief global functioning screen in predicting service use; c low inter-rater reliability among informants and clinicians for six of the most common diagnoses; and d clinician diagnoses differed between sites in ways that reflect different reimbursement strategies. The study concludes that clinicians and researchers should not assume diagnosis is a useful measure of child and adolescent problems and outcomes until there is more evidence supporting the validity of diagnosis.

  10. Active and Healthy Ageing as a Wicked Problem: The Contribution of a Multidisciplinary Research University.

    Science.gov (United States)

    Riva, Giuseppe; Graffigna, Guendalina; Baitieri, Maddalena; Amato, Alessandra; Bonanomi, Maria Grazia; Valentini, Paolo; Castelli, Guido

    2014-01-01

    The quest for an active and healthy ageing can be considered a "wicked problem." It is a social and cultural problem, which is difficult to solve because of incomplete, changing, and contradictory requirements. These problems are tough to manage because of their social complexity. They are a group of linked problems embedded in the structure of the communities in which they occur. First, they require the knowledge of the social and cultural context in which they occur. They can be solved only by understanding of what people do and why they do it. Second, they require a multidisciplinary approach. Wicked problems can have different solutions, so it is critical to capture the full range of possibilities and interpretations. Thus, we suggest that Università Cattolica del Sacro Cuore (UCSC) is well suited for accepting and managing this challenge because of its applied research orientation, multidisciplinary approach, and integrated vision. After presenting the research activity of UCSC, we describe a possible "systems thinking" strategy to consider the complexity and interdependence of active ageing and healthy living.

  11. College Students' Conceptions of Stem Cells, Stem Cell Research, and Cloning

    Science.gov (United States)

    Concannon, James P.; Siegel, Marcelle A.; Halverson, Kristy; Freyermuth, Sharyn

    2010-01-01

    In this study, we examined 96 undergraduate non-science majors' conceptions of stem cells, stem cell research, and cloning. This study was performed at a large, Midwest, research extensive university. Participants in the study were asked to answer 23 questions relating to stem cells, stem cell research, and cloning in an on-line assessment before…

  12. College Students' Conceptions of Stem Cells, Stem Cell Research, and Cloning

    Science.gov (United States)

    Concannon, James P.; Siegel, Marcelle A.; Halverson, Kristy; Freyermuth, Sharyn

    2010-01-01

    In this study, we examined 96 undergraduate non-science majors' conceptions of stem cells, stem cell research, and cloning. This study was performed at a large, Midwest, research extensive university. Participants in the study were asked to answer 23 questions relating to stem cells, stem cell research, and cloning in an on-line assessment before…

  13. Fundamentalism, multiculturalism and problems of conducting research with populations in developing nations.

    Science.gov (United States)

    Crigger, N J; Holcomb, L; Weiss, J

    2001-09-01

    A growing number of nurse researchers travel globally to conduct research in poor and underserved populations in developing nations. These researchers, while well versed in research ethics, often find it difficult to apply traditional ethical standards to populations in developing countries. The problem of applying ethical standards across cultures is explained by a long-standing debate about the nature of ethical principles. Fundamentalism is the philosophical stance that ethical principles are universal, while the anthropologically-based 'multicultural' model claims the philosophical position that principles are culturally bound. The authors explicate the two philosophical stances and advocate a morally sensitive but moderate position of 'ethical multiculturalism' rather than favouring either of the above philosophical positions. The final section suggests ways to promote ethical multiculturalism while planning and conducting nursing research.

  14. Subsynchronous Oscillation Problem Research in the UHVDC System of a Regional Power Grid in China

    Directory of Open Access Journals (Sweden)

    Qu Ying

    2016-01-01

    Full Text Available Along with the grid structure being more and more complex and the rapid development of the HVDC system, studying the subsynchronous oscillation (SSO problem on HVDC system has more engineering practice significance. The paper studies subsynchronous oscillations problem of generators near the ±800kV UHVDC converter station, and analyzes the subsynchronous oscillation possibilities through PSCAD/EMTDC simulation. At last, though the researched UHVDC thermal plants have none SSO risk but it needs other measures to make the relevant generators return on normal operation.

  15. Common statistical and research design problems in manuscripts submitted to high-impact medical journals

    Directory of Open Access Journals (Sweden)

    Harris Alex HS

    2011-08-01

    Full Text Available Abstract Background To assist educators and researchers in improving the quality of medical research, we surveyed the editors and statistical reviewers of high-impact medical journals to ascertain the most frequent and critical statistical errors in submitted manuscripts. Findings The Editors-in-Chief and statistical reviewers of the 38 medical journals with the highest impact factor in the 2007 Science Journal Citation Report and the 2007 Social Science Journal Citation Report were invited to complete an online survey about the statistical and design problems they most frequently found in manuscripts. Content analysis of the responses identified major issues. Editors and statistical reviewers (n = 25 from 20 journals responded. Respondents described problems that we classified into two, broad themes: A. statistical and sampling issues and B. inadequate reporting clarity or completeness. Problems included in the first theme were (1 inappropriate or incomplete analysis, including violations of model assumptions and analysis errors, (2 uninformed use of propensity scores, (3 failing to account for clustering in data analysis, (4 improperly addressing missing data, and (5 power/sample size concerns. Issues subsumed under the second theme were (1 Inadequate description of the methods and analysis and (2 Misstatement of results, including undue emphasis on p-values and incorrect inferences and interpretations. Conclusions The scientific quality of submitted manuscripts would increase if researchers addressed these common design, analytical, and reporting issues. Improving the application and presentation of quantitative methods in scholarly manuscripts is essential to advancing medical research.

  16. European stem cell research in legal shackles

    NARCIS (Netherlands)

    Nielen, M.G.; de Vries, S.A.; Geijsen, N.

    2013-01-01

    Advances in stem cell biology have raised legal challenges to the patentability of stem cells and any derived technologies and processes. In 1999, Oliver Brustle was granted a patent for the generation and therapeutic use of neural cells derived from human embryonic stem cells (hESCs). The patent wa

  17. [Problems in quality standard research of new traditional Chinese medicine compound].

    Science.gov (United States)

    Zhou, Gang; He, Yan-Ping

    2014-09-01

    The new traditional Chinese medicine compound is the main part of the research of new drug of traditional Chinese medicine (TCM), and the new Chinese herbal compound reflects the characteristics of TCM theory. The new traditional Chinese medicine compound quality standard research is one of the main content of pharmaceutical research, and is also the focus of the new medicine pharmaceutical evaluation content. Although in recent years the research level of new traditional Chinese medicine compound has been greatly improved, but the author during the review found still some common problems existing in new traditional Chinese medicine compound quality standard research data, this paper analyzed the current quality standards for new traditional Chinese medicine compound and the problems existing in the research data, respectively from measurement of the content of index selection, determine the scope of the content, and the quality standard design concept, the paper expounds developers need to concern. The quality of new traditional Chinese medicine compound quality standard is not only itself can be solved, but quality standards is to ensure the key and important content of product quality, improving the quality of products cannot do without quality standards. With the development of science and technology, on the basis of quality by design under the guidance of the concept, new traditional Chinese medicine compound quality standard system will be more scientific, systematic and perfect.

  18. Sourcing human embryos for embryonic stem cell lines: Problems & perspectives

    Directory of Open Access Journals (Sweden)

    Rajvi H Mehta

    2014-01-01

    Full Text Available The ability to successfully derive human embryonic stem cells (hESC lines from human embryos following in vitro fertilization (IVF opened up a plethora of potential applications of this technique. These cell lines could have been successfully used to increase our understanding of human developmental biology, transplantation medicine and the emerging science of regenerative medicine. The main source for human embryos has been ′discarded′ or ′spare′ fresh or frozen human embryos following IVF. It is a common practice to stimulate the ovaries of women undergoing any of the assisted reproductive technologies (ART and retrieve multiple oocytes which subsequently lead to multiple embryos. Of these, only two or maximum of three embryos are transferred while the rest are cryopreserved as per the decision of the couple. In case a couple does not desire to ′cryopreserve′ their embryos then all the embryos remaining following embryo transfer can be considered ′spare′ or if a couple is no longer in need of the ′cryopreserved′ embryos then these also can be considered as ′spare′. But, the question raised by the ethicists is, "what about ′slightly′ over-stimulating a woman to get a few extra eggs and embryos? The decision becomes more difficult when it comes to ′discarded′ embryos. As of today, the quality of the embryos is primarily assessed based on morphology and the rate of development mainly judged by single point assessment. Despite many criteria described in the literature, the quality assessment is purely subjective. The question that arises is on the decision of ′discarding′ embryos. What would be the criteria for discarding embryos and the potential ′use′ of ESC derived from the ′abnormal appearing′ embryos? This paper discusses some of the newer methods to procure embryos for the derivation of embryonic stem cell lines which will respect the ethical concerns but still provide the source material.

  19. Sourcing human embryos for embryonic stem cell lines: problems & perspectives.

    Science.gov (United States)

    Mehta, Rajvi H

    2014-11-01

    The ability to successfully derive human embryonic stem cells (hESC) lines from human embryos following in vitro fertilization (IVF) opened up a plethora of potential applications of this technique. These cell lines could have been successfully used to increase our understanding of human developmental biology, transplantation medicine and the emerging science of regenerative medicine. The main source for human embryos has been 'discarded' or 'spare' fresh or frozen human embryos following IVF. It is a common practice to stimulate the ovaries of women undergoing any of the assisted reproductive technologies (ART) and retrieve multiple oocytes which subsequently lead to multiple embryos. Of these, only two or maximum of three embryos are transferred while the rest are cryopreserved as per the decision of the couple. in case a couple does not desire to 'cryopreserve' their embryos then all the embryos remaining following embryo transfer can be considered 'spare' or if a couple is no longer in need of the 'cryopreserved' embryos then these also can be considered as 'spare'. But, the question raised by the ethicists is, "what about 'slightly' over-stimulating a woman to get a few extra eggs and embryos? The decision becomes more difficult when it comes to 'discarded' embryos. As of today, the quality of the embryos is primarily assessed based on morphology and the rate of development mainly judged by single point assessment. Despite many criteria described in the literature, the quality assessment is purely subjective. The question that arises is on the decision of 'discarding' embryos. What would be the criteria for discarding embryos and the potential 'use' of ESC derived from the 'abnormal appearing' embryos? This paper discusses some of the newer methods to procure embryos for the derivation of embryonic stem cell lines which will respect the ethical concerns but still provide the source material.

  20. Systemic Problems: A perspective on stem cell aging and rejuvenation

    Science.gov (United States)

    Conboy, Irina M.; Conboy, Michael J.; Rebo, Justin

    2015-01-01

    This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a “silver bullet” putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are “beyond parabiosis” for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging. PMID:26540176

  1. A Glimpse of Stem Cell Research in China

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhi-Guo; ZHANG Y.Alex

    2011-01-01

    2010 has seen rapid progress in stem cell research in China.Not only the major funding agencies had provided extensive funding to stem cell research,the publications by Chinese stem cell biologists also flourished in top-notch scientific journals.In this special review,we highlighted some recent studies that had been published in Science China Life Sciences and Cell Research,two key SCI journals based in China.Not surprisingly,these studies mainly focused on some of the highly pursued stem cell types:embryonic stem cells(ES cells),induced pluripotent stem cells (iPSCs),neural stem cells(NSCs)and mesenchymal stem cells(MSCs).

  2. Perspectives and controversies in the field of stem cell research.

    Science.gov (United States)

    Romano, Gaetano

    2006-09-01

    The fourth annual meeting of the International Society for Stem Cell Research focused on a number of pressing issues, including: (I) the need to better characterize the biology of stem cells; (II) the need to exploit and optimize the great therapeutic potential of stem cells in tissue regeneration; (III) ethical and safety considerations related to the use of human embryonic stem cells; (IV) the contribution of adult stem cells to carcinogenesis; (V) the need to investigate the biology of cancer stem cells. The purpose of this report is to summarize the current status of stem cell research, as surmised by the proceedings of this meeting.

  3. Problem Solving

    Science.gov (United States)

    Kinsella, John J.

    1970-01-01

    Discussed are the nature of a mathematical problem, problem solving in the traditional and modern mathematics programs, problem solving and psychology, research related to problem solving, and teaching problem solving in algebra and geometry. (CT)

  4. Excursions in classical analysis pathways to advanced problem solving and undergraduate research

    CERN Document Server

    Chen, Hongwei

    2010-01-01

    Excursions in Classical Analysis introduces undergraduate students to advanced problem solving and undergraduate research in two ways. Firstly, it provides a colourful tour of classical analysis which places a wide variety of problems in their historical context. Secondly, it helps students gain an understanding of mathematical discovery and proof. In demonstrating a variety of possible solutions to the same sample exercise, the reader will come to see how the connections between apparently inapplicable areas of mathematics can be exploited in problem-solving. This book will serve as excellent preparation for participation in mathematics competitions, as a valuable resource for undergraduate mathematics reading courses and seminars and as a supplement text in a course on analysis. It can also be used in independent study, since the chapters are free-standing.

  5. Interventions for comorbid problem gambling and psychiatric disorders: Advancing a developing field of research.

    Science.gov (United States)

    Dowling, N A; Merkouris, S S; Lorains, F K

    2016-07-01

    Despite significant psychiatric comorbidity in problem gambling, there is little evidence on which to base treatment recommendations for subpopulations of problem gamblers with comorbid psychiatric disorders. This mini-review draws on two separate systematic searches to identify possible interventions for comorbid problem gambling and psychiatric disorders, highlight the gaps in the currently available evidence base, and stimulate further research in this area. In this mini-review, only 21 studies that have conducted post-hoc analyses to explore the influence of psychiatric disorders or problem gambling subtypes on gambling outcomes from different types of treatment were identified. The findings of these studies suggest that most gambling treatments are not contraindicated by psychiatric disorders. Moreover, only 6 randomized studies comparing the efficacy of interventions targeted towards specific comorbidity subgroups with a control/comparison group were identified. The results of these studies provide preliminary evidence for modified dialectical behavior therapy for comorbid substance use, the addition of naltrexone to cognitive-behavioral therapy (CBT) for comorbid alcohol use problems, and the addition of N-acetylcysteine to tobacco support programs and imaginal desensitisation/motivational interviewing for comorbid nicotine dependence. They also suggest that lithium for comorbid bipolar disorder, escitalopram for comorbid anxiety disorders, and the addition of CBT to standard drug treatment for comorbid schizophrenia may be effective. Future research evaluating interventions sequenced according to disorder severity or the functional relationship between the gambling behavior and comorbid symptomatology, identifying psychiatric disorders as moderators of the efficacy of problem gambling interventions, and evaluating interventions matched to client comorbidity could advance this immature field of study.

  6. Human embryonic stem cell research debates: a confucian argument.

    Science.gov (United States)

    Tsai, D F-C

    2005-11-01

    Human embryonic stem cell research can bring about major biomedical breakthroughs and thus contribute enormously to human welfare, yet it raises serious moral problems because it involves using human embryos for experiment. The "moral status of the human embryo" remains the core of such debates. Three different positions regarding the moral status of the human embryo can be categorised: the "all" position, the "none" position, and the "gradualist" position. The author proposes that the "gradualist" position is more plausible than the other two positions. Confucius's moral principle of jen, which proposes a unique theory of "love of gradation", and the principle of yi, which advocates "due treatment for persons", are then explored. The author then argues that our moral obligations to do good to other living organisms, persons, and our families are different. Putting together the "gradualist" position on the human embryo, and Confucius's theories of "love of gradation" and "due treatment for persons", the author concludes that the early embryo has less ethical significance than the later fetus and adult human. The moral obligation we have toward persons is clearer and stronger than that which we have toward human embryos. Embryo research is justifiable if it brings enormous welfare to human persons that cannot be otherwise achieved. The "love of gradation" requires us, however, to extend love and respect towards other entities according to their different status. We should therefore be very cautious in using human embryos for research, acknowledging the gradualist nature of their moral status.

  7. Problems with change in R2 as applied to theory of reasoned action research.

    Science.gov (United States)

    Trafimow, David

    2004-12-01

    The paradigm of choice for theory of reasoned action research seems to depend largely on the notion of change in variance accounted for (DeltaR2) as new independent variables are added to a multiple regression equation. If adding a particular independent variable of interest increases the variance in the dependent variable that can be accounted for by the list of independent variables, then the research is deemed to be 'successful', and the researcher is considered to have made a convincing argument about the importance of the new variable. In contrast to this trend, I present arguments that suggest serious problems with the paradigm, and conclude that studies on attitude-behaviour relations would advance the field of psychology to a far greater extent if researchers abandoned it.

  8. Stem cell research:from molecular physiology to therapeutic applications

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Stem cell research promises remedies to many devastating diseases that are currently incurable, ranging from diabetes and Parkinson’s disease to paralysis. Totipotent embryonic stem cells have great potential for generating a wide

  9. Problem gambling worldwide: An update and systematic review of empirical research (2000-2015).

    Science.gov (United States)

    Calado, Filipa; Griffiths, Mark D

    2016-12-01

    Background and aims Problem gambling has been identified as an emergent public health issue, and there is a need to identify gambling trends and to regularly update worldwide gambling prevalence rates. This paper aims to review recent research on adult gambling and problem gambling (since 2000) and then, in the context of a growing liberalization of the gambling market in the European Union, intends to provide a more detailed analysis of adult gambling behavior across European countries. Methods A systematic literature search was carried out using academic databases, Internet, and governmental websites. Results Following this search and utilizing exclusion criteria, 69 studies on adult gambling prevalence were identified. These studies demonstrated that there are wide variations in past-year problem gambling rates across different countries in the world (0.12-5.8%) and in Europe (0.12-3.4%). However, it is difficult to directly compare studies due to different methodological procedures, instruments, cut-offs, and time frames. Despite the variability among instruments, some consistent results with regard to demographics were found. Discussion and conclusion The findings highlight the need for continuous monitoring of problem gambling prevalence rates in order to examine the influence of cultural context on gambling patterns, assess the effectiveness of policies on gambling-related harms, and establish priorities for future research.

  10. Ethical issues in stem cell research and therapy.

    Science.gov (United States)

    King, Nancy Mp; Perrin, Jacob

    2014-07-07

    Rapid progress in biotechnology has introduced a host of pressing ethical and policy issues pertaining to stem cell research. In this review, we provide an overview of the most significant issues with which the stem cell research community should be familiar. We draw on a sample of the bioethics and scientific literatures to address issues that are specific to stem cell research and therapy, as well as issues that are important for stem cell research and therapy but also for translational research in related fields, and issues that apply to all clinical research and therapy. Although debate about the moral status of the embryo in human embryonic stem cell research continues to have relevance, the discovery of other highly multipotent stem cell types and alternative methods of isolating and creating highly multipotent stem cells has raised new questions and concerns. Induced pluripotent stem cells hold great promise, but care is needed to ensure their safety in translational clinical trials, despite the temptation to move quickly from bench to bedside. A variety of highly multipotent stem cells - such as mesenchymal stem/stromal cells and stem cells derived from amniotic fluid, umbilical cord blood, adipose tissue, or urine - present the opportunity for widespread biobanking and increased access. With these increased opportunities, however, come pressing policy issues of consent, control, and justice. The imperatives to minimize risks of harm, obtain informed consent, reduce the likelihood of the therapeutic misconception, and facilitate sound translation from bench to bedside are not unique to stem cell research; their application to stem cell research and therapy nonetheless merits particular attention. Because stem cell research is both scientifically promising and ethically challenging, both the application of existing ethical frameworks and careful consideration of new ethical implications are necessary as this broad and diverse field moves forward.

  11. Symposium Connects Government Problems with State of the Art Network Science Research

    Science.gov (United States)

    2015-10-16

    the new era of data democratization and user self-awareness and empowerment . Noise and interference in networks: Exploiting graphs in the...exploitation of graph data. The goal was to bring together academic research- ers, industry practitioners, and end users to discuss problems of interest to...robustly handle stochastic cascades on the network and be able to localize control effects. User -centric algorithms: Combining user -centric

  12. Guidelines for the use of cell lines in biomedical research.

    Science.gov (United States)

    Geraghty, R J; Capes-Davis, A; Davis, J M; Downward, J; Freshney, R I; Knezevic, I; Lovell-Badge, R; Masters, J R W; Meredith, J; Stacey, G N; Thraves, P; Vias, M

    2014-09-09

    Cell-line misidentification and contamination with microorganisms, such as mycoplasma, together with instability, both genetic and phenotypic, are among the problems that continue to affect cell culture. Many of these problems are avoidable with the necessary foresight, and these Guidelines have been prepared to provide those new to the field and others engaged in teaching and instruction with the information necessary to increase their awareness of the problems and to enable them to deal with them effectively. The Guidelines cover areas such as development, acquisition, authentication, cryopreservation, transfer of cell lines between laboratories, microbial contamination, characterisation, instability and misidentification. Advice is also given on complying with current legal and ethical requirements when deriving cell lines from human and animal tissues, the selection and maintenance of equipment and how to deal with problems that may arise.

  13. Research priorities for non-pharmacological therapies for common musculoskeletal problems: nationally and internationally agreed recommendations

    Directory of Open Access Journals (Sweden)

    Windt Danielle

    2009-01-01

    Full Text Available Abstract Background Musculoskeletal problems such as low back pain, neck, knee and shoulder pain are leading causes of disability and activity limitation in adults and are most frequently managed within primary care. There is a clear trend towards large, high quality trials testing the effectiveness of common non-pharmacological interventions for these conditions showing, at best, small to moderate benefits. This paper summarises the main lessons learnt from recent trials of the effectiveness of non-pharmacological therapies for common musculoskeletal conditions in primary care and provides agreed research priorities for future clinical trials. Methods Consensus development using nominal group techniques through national (UK and international workshops. During a national Clinical Trials Thinktank workshop in April 2007 in the UK, a group of 30 senior researchers experienced in clinical trials for musculoskeletal conditions and 2 patient representatives debated the possible explanations for the findings of recent high quality trials of non-pharmacological interventions. Using the qualitative method of nominal group technique, these experts developed and ranked a set of priorities for future research, guided by the evidence from recent trials of treatments for common musculoskeletal problems. The recommendations from the national workshop were presented and further ranked at an international symposium (hosted in Canada in June 2007. Results 22 recommended research priorities were developed, of which 12 reached consensus as priorities for future research from the UK workshop. The 12 recommendations were reduced to 7 agreed priorities at the international symposium. These were: to increase the focus on implementation (research into practice; to develop national musculoskeletal research networks in which large trials can be sited and smaller trials supported; to use more innovative trial designs such as those based on stepped care and subgrouping for

  14. Translational research of adult stem cell therapy.

    Science.gov (United States)

    Suzuki, Gen

    2015-11-26

    Congestive heart failure (CHF) secondary to chronic coronary artery disease is a major cause of morbidity and mortality world-wide. Its prevalence is increasing despite advances in medical and device therapies. Cell based therapies generating new cardiomyocytes and vessels have emerged as a promising treatment to reverse functional deterioration and prevent the progression to CHF. Functional efficacy of progenitor cells isolated from the bone marrow and the heart have been evaluated in preclinical large animal models. Furthermore, several clinical trials using autologous and allogeneic stem cells and progenitor cells have demonstrated their safety in humans yet their clinical relevance is inconclusive. This review will discuss the clinical therapeutic applications of three specific adult stem cells that have shown particularly promising regenerative effects in preclinical studies, bone marrow derived mesenchymal stem cell, heart derived cardiosphere-derived cell and cardiac stem cell. We will also discuss future therapeutic approaches.

  15. Translational research of adult stem cell therapy

    Institute of Scientific and Technical Information of China (English)

    Gen; Suzuki

    2015-01-01

    Congestive heart failure(CHF) secondary to chronic coronary artery disease is a major cause of morbidity and mortality world-wide. Its prevalence is increasing despite advances in medical and device therapies. Cell based therapies generating new cardiomyocytes and vessels have emerged as a promising treatment to reverse functional deterioration and prevent the progression to CHF. Functional efficacy of progenitor cells isolated from the bone marrow and the heart have been evaluated in preclinical large animal models. Furthermore, several clinical trials using autologous and allogeneic stem cells and progenitor cells have demonstrated their safety in humans yet their clinical relevance is inconclusive. This review will discuss the clinical therapeutic applications of three specific adult stem cells that have shown particularly promising regenerative effects in preclinical studies, bone marrow derived mesenchymal stem cell, heart derived cardiosphere-derived cell and cardiac stem cell. We will also discuss future therapeutic approaches.

  16. Micro-Cognitive-Processes at the Interface Research-Education-Problem Solving

    Directory of Open Access Journals (Sweden)

    Josiane Caron-Pargue

    2013-02-01

    Full Text Available A first part of this paper gives a rough picture of some difficulties encountered in research, in education, and in problem solving, for integrating them to one another. One can notice a much too global characterization of cognitive processes and a lack in the characterization of semiotic aspects. A second part analyses some theoretical limits to this integration. They are mainly due to the current conception of memories unable to take into consideration the micro-cognitive-processes at work under the reorganizations of knowledge when actualized within the situation. A third part presents a way toward the integration research-education-problem solving, relying on a cognitive approach of Culioli's enunciative theory of language, and presents some of the author's data. Micro-cognitive-processes are depicted in terms of the construction of aggregates (declarative versus procedural ones, standing at different levels of internalization and externalization, and of different processes of detachment from the situation. Then several kinds of interactions allow an on-line identification of the constraints of the task. The characterization of these constraints seems basic for each of the considered areas, research, education, and problem solving.

  17. Assessing the status of research on violence-related problems among youth.

    Science.gov (United States)

    Acosta, O M; Albus, K E; Reynolds, M W; Spriggs, D; Weist, M D

    2001-06-01

    Presents results of a systematic review of abstracts on studies related to violence and youth in an effort to identify areas that have received little attention in the psychological literature and to present recommendations for future research. A total of 1,168 empirical articles on violence-related problems in youth were identified by a PsycINFO (American Psychological Association, 1980-1999) search. These articles were then classified in a multidimensional grid, allowing for comparisons among different types of articles. A review of abstracts from these articles indicated that most of the research activity has been descriptive (e.g., reviewing correlates or predictors of violence involvement) or assessment related (e.g., evaluating specific measures). Fewer articles examined the treatment or prevention of violence-related problems among youth. Further, the majority of studies pertained to direct exposure to violence (as a victim or perpetrator), with very few studies looking at the effects of witnessing violence, knowing individuals exposed to violence, or being exposed to violence through the media. Comparing treatment and prevention articles, we found that the least empirical attention was paid to the prevention of violence-related problems in youth, and not a single study was identified through this search that sought to examine the prevention of youth witnessing violence. Implications for future research agendas are discussed.

  18. Commercialization and stem cell research: a review of emerging issues.

    Science.gov (United States)

    Burningham, Sarah; Ollenberger, Adam; Caulfield, Timothy

    2013-12-01

    Stem cell researchers face pressure to develop therapies that will reach the clinic within a short period of time. Yet, this pressure may be unrealistic, as bringing stem cell innovations to the clinic will likely require significant time and financial investment. In a variety of biomedical fields, some evidence suggests that commercialization pressures and strategies may negatively impact research. These negative impacts may also be felt in the field of stem cell research, unless the challenges and issues are addressed in the design and implementation of commercialization policies. Further inquiry into the impact of commercialization on the field of stem cell research is required.

  19. Erroneous efficiency reports harm organic solar cell research

    Science.gov (United States)

    Zimmermann, Eugen; Ehrenreich, Philipp; Pfadler, Thomas; Dorman, James A.; Weickert, Jonas; Schmidt-Mende, Lukas

    2014-09-01

    Mischaracterization of solar cell power conversion efficiencies and widespread publication of inconsistent data in scientific journals threatens to undermine progress in organic and hybrid photovoltaics research.

  20. Electrocatalysis research for fuel cells and hydrogen production

    CSIR Research Space (South Africa)

    Mathe, MK

    2012-01-01

    Full Text Available The CSIR undertakes research in the Electrocatalysis of fuel cells and for hydrogen production. The Hydrogen South Africa (HySA) strategy supports research on electrocatalysts due to their importance to the national beneficiation strategy. The work...

  1. Children's Media Use and Sleep Problems: Issues and Unanswered Questions. Research Brief

    Science.gov (United States)

    Zimmerman, Frederick J.

    2008-01-01

    Research shows that most children and adolescents do not get enough high-quality sleep, and that their sleep times appear to have declined over the last two decades. Coinciding with this trend has been the rise in popularity of new media forms including the Internet, video games, cell phones and DVDs. Because of the immediacy and interactivity of…

  2. Convergence of Cell Based Finite Volume Discretizations for Problems of Control in the Conduction Coefficients

    DEFF Research Database (Denmark)

    Evgrafov, Anton; Gregersen, Misha Marie; Sørensen, Mads Peter

    2011-01-01

    design, in particular shape and topology optimization, and are most often solved numerically utilizing a finite element approach. Within the FV framework for control in the coefficients problems the main difficulty we face is the need to analyze the convergence of fluxes defined on the faces of cells......We present a convergence analysis of a cell-based finite volume (FV) discretization scheme applied to a problem of control in the coefficients of a generalized Laplace equation modelling, for example, a steady state heat conduction. Such problems arise in applications dealing with geometric optimal...

  3. ”Generalizability” as Recognition: Reflections on a Foundational Problem in Qualitative Research

    Directory of Open Access Journals (Sweden)

    Charlotte Delmar

    2010-10-01

    Full Text Available The aim of the article is to develop what counts as “generalizability” in qualitative research. By taking an ontological and epistemic stance in relation to the four foundational problems: 1Knowledge and its various forms. 2 Properties of reality and the doubleness of the situation. 3 How is understanding possible? 4 The researcher’s role: What are the fundamental questions that the researcher must ask himself before a study is designed? we are able to approach the exploration of ”generalizability” in qualitative research. Methodological theorists agree that the question of applicability is essential in the discussion of “generalizability” in qualitative research. If the quantitative tradition’s requirement for replicability also has to be met, the pressing question during the article is what counts as replicability and applicability in qualitative research. In the exploration of what is involved in “generalizability” in qualitative research a combination of Gadamer and Flyvbjerg´s thinking are important sources for a reflection on the ontological and epistemic questions related to the four foundational problems. The ontological question of what establishes a situation is an essential interpretation for the finding. A situation is characterised by its quality of doubleness: it is unique and typical at the same time. People with each their unique story and life world constitute the uniqueness of the situation. And a situation is typical in the sense that fundamental experiences can be found in every situation. The typical is what we as people have in common. There will be typical traits and recogizable patterns in every situation. The finding show us that “generalizability” in qualitative research builds on recognisability and a challenge to practice as a practical reasoning.

  4. Stem cell research: from molecular physiology to therapeutic applications

    Institute of Scientific and Technical Information of China (English)

    Chengyu Jiang

    2009-01-01

    @@ Stem cell research promises remedies to many devastating diseases that are currently incurable, ranging from diabetes and Parkinson's disease to paralysis. Totipotent embryonic stem cells have great potential for generating a wide range of different human cells that can be used to restore malfunctioning or damaged cells and tissues in patients. Recent studies have shown that pluripotent stem cells derived from adult bone marrow, the umbilical cord and the placenta could also be induced to differentiate into a variety of different tissues. In this issue, we have invited several scientists in China to summarize their pioneering works in the stem cell research field.

  5. A problem-solving education intervention in caregivers and patients during allogeneic hematopoietic stem cell transplantation.

    Science.gov (United States)

    Bevans, Margaret; Wehrlen, Leslie; Castro, Kathleen; Prince, Patricia; Shelburne, Nonniekaye; Soeken, Karen; Zabora, James; Wallen, Gwenyth R

    2014-05-01

    The aim of this study was to determine the effect of problem-solving education on self-efficacy and distress in informal caregivers of allogeneic hematopoietic stem cell transplantation patients. Patient/caregiver teams attended three 1-hour problem-solving education sessions to help cope with problems during hematopoietic stem cell transplantation. Primary measures included the Cancer Self-Efficacy Scale-transplant and Brief Symptom Inventory-18. Active caregivers reported improvements in self-efficacy (p caregiver responders also reported better health outcomes such as fatigue. The effect of problem-solving education on self-efficacy and distress in hematopoietic stem cell transplantation caregivers supports its inclusion in future interventions to meet the multifaceted needs of this population.

  6. How can we improve problem solving in undergraduate biology? Applying lessons from 30 years of physics education research.

    Science.gov (United States)

    Hoskinson, A-M; Caballero, M D; Knight, J K

    2013-06-01

    If students are to successfully grapple with authentic, complex biological problems as scientists and citizens, they need practice solving such problems during their undergraduate years. Physics education researchers have investigated student problem solving for the past three decades. Although physics and biology problems differ in structure and content, the instructional purposes align closely: explaining patterns and processes in the natural world and making predictions about physical and biological systems. In this paper, we discuss how research-supported approaches developed by physics education researchers can be adopted by biologists to enhance student problem-solving skills. First, we compare the problems that biology students are typically asked to solve with authentic, complex problems. We then describe the development of research-validated physics curricula emphasizing process skills in problem solving. We show that solving authentic, complex biology problems requires many of the same skills that practicing physicists and biologists use in representing problems, seeking relationships, making predictions, and verifying or checking solutions. We assert that acquiring these skills can help biology students become competent problem solvers. Finally, we propose how biology scholars can apply lessons from physics education in their classrooms and inspire new studies in biology education research.

  7. Globalization and the contemporary development of Marxist philosophy: precondition, problem domain and research outline

    Institute of Scientific and Technical Information of China (English)

    Ouyang Kang

    2006-01-01

    Globalization was just emerging but did not really take shape during Karl Marx's time.In fact,both Karl Marx and Engels predicted the trend of globalization but did not really live in such a time.Therefore,globalization is still a new issue and a new research area for Marxist philosophy today.Based on the distinctions between some important concepts such as globalization and modernization,this paper probes the problems concerning the development of modernity theory,social morphology and civilization theory,and the Marxist theory of values raised in the process of globalization.The paper also explores some theoretical issues concerning the socialist modernization with Chinese characteristics in the Marxist philosophy,and contemplates possible research areas,angles and methods of Marxist philosophical research in the global era.

  8. The role of nanotechnology in induced pluripotent and embryonic stem cells research.

    Science.gov (United States)

    Chen, Lukui; Qiu, Rong; Li, Lushen

    2014-12-01

    This paper reviews the recent studies on development of nanotechnology in the field of induced pluripotent and embryonic stem cells. Stem cell therapy is a promising therapy that can improve the quality of life for patients with refractory diseases. However, this option is limited by the scarcity of tissues, ethical problem, and tumorigenicity. Nanotechnology is another promising therapy that can be used to mimic the extracellular matrix, label the implanted cells, and also can be applied in the tissue engineering. In this review, we briefly introduce implementation of nanotechnology in induced pluripotent and embryonic stem cells research. Finally, the potential application of nanotechnology in tissue engineering and regenerative medicine is also discussed.

  9. A Glimpse of Scientific Research on Fundamental Problems of Military and Civil Aeronautics

    Science.gov (United States)

    1939-01-01

    Among the outstanding accomplishments of the last century is man's conquest of the air. That conquest began in 1903 when the Wright brothers made the first successful flight of an airplane at Kitty Hawk, N. C. Five years later the United States Government purchased its first airplane for the use of the Army, and began the training of officers for military flying. During the years immediately preceding the outbreak of the World War the Government and a meager aircraft industry had made important progress, but the Government, practically the only customer, had purchased less than 100 airplanes. In the meantime, leading European nations, sensing acutely the potentialities of aircraft in warfare, had made greater progress and had begun laying the foundations for the new science of aeronautics. The World War gave a remarkable impetus to the development of aeronautics and emphasized the need for organized research on the fundamental problems of flight. By act of Congress approved March 3, 1915, the National Advisory Committee for Aeronautics was created and charged with the duty of supervising, directing, and conducting fundamental scientific research and experiment in aeronautics. With the farsighted support of the Congress the Committee has led the world in the development of unique aeronautical research facilities in its laboratories at Langley Field, Va. The research programs include problems initiated by the Committee and its subcommittees and also investigations requested by the Army, the Navy, and the Civil Aeronautics Authority. The results of researches conducted under one control, serve without duplication of effort, the needs of all branches of aviation, civil and military, and exert a profound influence on the progress of aeronautics by improving the performance, efficiency, and safety of aircraft. A brief description of the results of some of the committee's researches and of the equipment employed will be found in the following pages.

  10. Thymic selection of T-cell receptors as an extreme value problem

    CERN Document Server

    Kosmrlj, Andrej; Kardar, Mehran; Shakhnovich, Eugene I

    2009-01-01

    T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors (TCRs) on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility (MHC) gene products (displayed on antigen presenting cells). A diverse and self-tolerant T cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected TCRs (which enable its recognition functions).

  11. A RESEARCH ON INSTITUTIONALIZATION PROBLEMS OF SECOND GENERATION IN FAMILY BUSINESS

    Directory of Open Access Journals (Sweden)

    Kezban Esra SARAL KOBAL

    2016-08-01

    Full Text Available All family enterprises nowadays are trying to have competitive advantage in their market and increase the productivity and efficiency of their operations. These are mandatory factors for those companies to survive and stay competitive in their markets. Institutionalization is one of the most important elements provides enterprises better competitive advantage, productivity and efficiency. This study aims to specify the level of institutionalization at family business and the problems that second generation of the related family faces during the institutionalization process. Because of this, study emphasizes, family business, institutionalization and second generation of the family’s problems. In parallel with the goal of this study, first institutionalization and levels of institutionalization will be shortly described. After this, the details of the problems that second generations are facing shall be determined. As the last concept of this study, the fundamentals of institutionalization at family business and corporate management will be analyzed. This study consisted of 3 sections. The first section is about the analysis of literature, second section defines the corporate fundamentals of the research and definition of the basic concepts, last section is about evaluation of the research and findings.

  12. Internet as a resource for solving the problems of adolescence: a review of psychological research

    Directory of Open Access Journals (Sweden)

    A.V. Zhilinskaya,

    2014-08-01

    Full Text Available We analyzed psychological research that consider the Internet as a resource for solving the problems of adolescence. Based on the understanding of self-consciousness as a central adolescence new formation, we formulated a set of tasks of adolescence. It is shown that for the successful solution of age problems by teenagers on the Internet, specialized environments should be designed. Internet as a medium of teenagers’ socialization is characterized by a high degree of variety and uncontrollability. Behavior of adolescents on the Internet depends on the social and cultural context in which they live. The emergence of the Internet makes new demands on media competence of the teenager and his environment. Adolescents face online with a variety of risks. An essential resource for successful adolescent development is the presence of a person whom he trusts, with whom he can consult in difficult situations. The research plan involves the creation of Internet resources, contributing to the solution of teenagers’ problems age, as well as the mapping of the Internet in terms of its developmental potential.

  13. Taking power, politics, and policy problems seriously: the limits of knowledge translation for urban health research.

    Science.gov (United States)

    Murphy, Kelly; Fafard, Patrick

    2012-08-01

    Knowledge translation (KT) is a growing movement in clinical and health services research, aimed to help make research more relevant and to move research into practice and policy. This paper examines the conventional model of policy change presented in KT and assesses its applicability for increasing the impact of urban health research on urban health policy. In general, KT conceptualizes research utilization in terms of the technical implementation of scientific findings, on the part of individual decision-makers who can be "targeted" for a KT intervention, in a context that is absent of political interests. However, complex urban health problems and interventions infrequently resemble this single decision, single decision-maker model posited by KT. In order to clarify the conditions under which urban health research is more likely or not to have an influence on public policy development, we propose to supplement the conventional model with three concepts drawn from the social science: policy stages, policy networks, and a discourse analysis approach for theorizing power in policy-making.

  14. Quality of life of people with mental health problems: a synthesis of qualitative research

    Directory of Open Access Journals (Sweden)

    Connell Janice

    2012-11-01

    Full Text Available Abstract Purpose To identify the domains of quality of life important to people with mental health problems. Method A systematic review of qualitative research undertaken with people with mental health problems using a framework synthesis. Results We identified six domains: well-being and ill-being; control, autonomy and choice; self-perception; belonging; activity; and hope and hopelessness. Firstly, symptoms or ‘ill-being’ were an intrinsic aspect of quality of life for people with severe mental health problems. Additionally, a good quality of life was characterised by the feeling of being in control (particularly of distressing symptoms, autonomy and choice; a positive self-image; a sense of belonging; engagement in meaningful and enjoyable activities; and feelings of hope and optimism. Conversely, a poor quality life, often experienced by those with severe mental health difficulties, was characterized by feelings of distress; lack of control, choice and autonomy; low self-esteem and confidence; a sense of not being part of society; diminished activity; and a sense of hopelessness and demoralization. Conclusions Generic measures fail to address the complexity of quality of life measurement and the broad range of domains important to people with mental health problems.

  15. Some Problems in the Research of Cartographic Representations of Croatian Cities from the 16th Century

    Directory of Open Access Journals (Sweden)

    Ivka Kljajić

    2006-12-01

    Full Text Available Analysis of representations of Croatian cities bound into five manuscript atlases: two atlases (signature Cod. 8607 and Cod. 8609 from the Collection of Manuscripts, Documents and Heritage of the AustrianNational Library (Handschriften-, Autographen- und Nachlass-Sammlung der Österreichischen Nationalbibliothek in Vienna, two (signature Schr. XXVI, F. 96, Nr. 6 and Schr. XXVI, F. 96, Nr. 11 from the Saxon Central State Archive (Sächsisches Hauptstaatsarchiv in Dresden and one (signature Hfk. Bd. XV from the Main Land Archive (Generallandesarchiv in Karlsruhe. Some of the problems encountered during the research are described and explained in the paper. They are: determination of more accurate data about the first discoveries about the existence of representations of Croatian cities, the titles of the atlases and the time of their production. Incorrect signature citation is stressed, as well as the problem of incomplete data. 

  16. An Existential Perspective on Death Anxiety, Retirement, and Related Research Problems.

    Science.gov (United States)

    Osborne, John W

    2017-06-01

    Aspects of existentialism relevant to existence and death anxiety (DA) are discussed. Included are the "thrownness" of existence, being-with-others, the motivational influence of inevitable death, the search for meaning, making the most of existence by taking responsibility for one's own life, and coping with existential isolation. The attempted separation of DA from object anxiety is a significant difficulty. The correlations among age, gender, and DA are variable. Personality and role-oriented problems in the transition to retirement are discussed along with Erikson's notion of "generativity" as an expression of the energy and purpose of mid-life. Furthermore, methodological and linguistic problems in DA research are considered. The article suggests qualitative methodologies as an interpersonal means of exploring DA within the contexts of psychotherapy and counselling.

  17. The implications of different developmental patterns of disruptive behavior problems for school adjustment. Conduct Problems Prevention Research Group.

    Science.gov (United States)

    Stormshak, E A; Bierman, K L

    1998-01-01

    Based upon developmental models of disruptive behavior problems, this study examined the hypothesis that the nature of a child's externalizing problems at home may be important in predicting the probability of and nature of school adjustment problems at school entry. Parent ratings were collected for a sample of 631 behaviorally disruptive children using the Child Behavior Checklist. Confirmatory factor analyses revealed differentiated ratings of oppositional, aggressive, and hyperactive/inattentive behaviors at home. Teacher and peer nominations assessed school adjustment at the end of first grade. As expected from a developmental perspective, aggressive behaviors indicated more severe dysfunction and were more likely to generalize to the school setting than were oppositional behaviors. Hyperactive/inattentive behaviors at home led to more classroom disruption than did aggressive or oppositional behaviors. Co-occurring patterns of oppositional/aggressive and hyperactive/inattentive behaviors were more common than were single-problem patterns, and were associated with broad dysfunction in the social and classroom contexts. The results were interpreted within a developmental framework, in which oppositional, aggressive, and hyperactive/inattentive behaviors may reflect distinct (as well as shared) developmental processes that have implications for the home-to-school generalization of behavior problems and subsequent school adjustment.

  18. Potential high efficiency solar cells: Applications from space photovoltaic research

    Science.gov (United States)

    Flood, D. J.

    1986-01-01

    NASA involvement in photovoltaic energy conversion research development and applications spans over two decades of continuous progress. Solar cell research and development programs conducted by the Lewis Research Center's Photovoltaic Branch have produced a sound technology base not only for the space program, but for terrestrial applications as well. The fundamental goals which have guided the NASA photovoltaic program are to improve the efficiency and lifetime, and to reduce the mass and cost of photovoltaic energy conversion devices and arrays for use in space. The major efforts in the current Lewis program are on high efficiency, single crystal GaAs planar and concentrator cells, radiation hard InP cells, and superlattice solar cells. A brief historical perspective of accomplishments in high efficiency space solar cells will be given, and current work in all of the above categories will be described. The applicability of space cell research and technology to terrestrial photovoltaics will be discussed.

  19. Research problems and trends of the pharmaceutical market Sudan as social oriented structure of the country

    Directory of Open Access Journals (Sweden)

    Олена Миколаївна Євтушенко

    2016-04-01

    Full Text Available Aim: The research object was the definition of problems and tendencies of pharmaceutical market development of Sudan as the country which in recent years tries to pull through the consequence of political and economic crisis and to build the socially oriented model of the state.Methods: In the researches it has been used the marketing and economic analysis methods as well as the historical, logical, comparative and graphic methods.Results: The authors represented the marketing analysis results of pharmaceutical market of Sudan. It has been identified the main problems and tendencies of it development. It has been made the macroeconomic indexes analysis which has the influence to the availability level of the pharmaceutical assistance to the population of the country. It has been studied the spending dynamics of the medical and pharmaceutical provision per capita in the country, the tendencies of the amounts changes in the pharmaceutical market, the branded market structure. It has been established the position of Sudan according to the national systems division of the public health and pharmaceutical assistance of population depending on the macroeconomic indexes of region development.Conclusions: It has been established the positive and negative tendencies indicative to the modern state of the county. After the research results it has been distinguished the further development directions especially the actions for the rational model creation for the population assistance in public health

  20. JEFC PROBLEMS AND POSSIBLE SOLUTIONS IN XINJIANG UYGUR AUTONOMOUS REGION——A Report of JEFC Research in Xinjiang

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Foreword JEFC Research is one of the ten education research items of the eighth-five- year plan in Xinjiang U. A. R. The research mainly focuses on the new syllabus, JEFC itself, the new methodology, teacher training and problems and solutions of JEFC in Xinjiang. The research has been finished with the hard work of the researchers and the help of some experts and VSO teachers. Many thanks to these kind people. The following is a report of the research into the main problems and solutions of JEFC teaching in Xinjiang.

  1. Stem cell concepts renew cancer research.

    Science.gov (United States)

    Dick, John E

    2008-12-15

    Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the individual cells that make up the tumor exhibit considerable variation in many properties, including morphology, proliferation kinetics, and the ability to initiate tumor growth in transplant assays. Understanding the molecular and cellular basis of this heterogeneity has important implications in the design of therapeutic strategies. The mechanistic basis of tumor heterogeneity has been uncertain; however, there is now strong evidence that cancer is a cellular hierarchy with cancer stem cells at the apex. This review provides a historical overview of the influence of hematology on the development of stem cell concepts and their linkage to cancer.

  2. Trends and Prospects of Stem Cell Research in China

    Institute of Scientific and Technical Information of China (English)

    Jing-wen Cao; Lu Zhang; Ye Li; Qing Yang; Wen-hua Fu; Xiao-chen Wang; Wen-long Huang

    2016-01-01

    Great progresses have been made in fundamental and clinical stem cell research in China in recent years. The official policy on stem cells, which was announced in 2015, seems as the spring of stem cell therapy in China. However, the regulation, governance, and management of clinical expectations are still challenging. This review summarized the current stem cell research and development in the field, as well as its rapidly evolving commercial, regulatory and ethical environment in China. As expected, the prospects of stem cells in China look prospective.

  3. Acoel and platyhelminth models for stem-cell research

    Science.gov (United States)

    2010-01-01

    Acoel and platyhelminth worms are particularly attractive invertebrate models for stem-cell research because their bodies are continually renewed from large pools of somatic stem cells. Several recent studies, including one in BMC Developmental Biology, are beginning to reveal the cellular dynamics and molecular basis of stem-cell function in these animals. See research article http://www.biomedcentral.com/1471-213X/9/69. PMID:20236484

  4. Human embryonic stem cell research: ethical and legal issues.

    Science.gov (United States)

    Robertson, J A

    2001-01-01

    The use of human embryonic stem cells to replace damaged cells and tissues promises future hope for the treatment of many diseases. However, many countries now face complex ethical and legal questions as a result of the research needed to develop these cell-replacement therapies. The challenge that must be met is how to permit research on human embryonic tissue to occur while maintaining respect for human life generally.

  5. Software design as a problem in learning theory (a research overview)

    Science.gov (United States)

    Fass, Leona F.

    1992-01-01

    Our interest in automating software design has come out of our research in automated reasoning, inductive inference, learnability, and algebraic machine theory. We have investigated these areas extensively, in connection with specific problems of language representation, acquisition, processing, and design. In the case of formal context-free (CF) languages we established existence of finite learnable models ('behavioral realizations') and procedures for constructing them effectively. We also determined techniques for automatic construction of the models, inductively inferring them from finite examples of how they should 'behave'. These results were obtainable due to appropriate representation of domain knowledge, and constraints on the domain that the representation defined. It was when we sought to generalize our results, and adapt or apply them, that we began investigating the possibility of determining similar procedures for constructing correct software. Discussions with other researchers led us to examine testing and verification processes, as they are related to inference, and due to their considerable importance in correct software design. Motivating papers by other researchers, led us to examine these processes in some depth. Here we present our approach to those software design issues raised by other researchers, within our own theoretical context. We describe our results, relative to those of the other researchers, and conclude that they do not compare unfavorably.

  6. Research on the Optimal Parallel Algorithms of Broadcast—Class Problems

    Institute of Scientific and Technical Information of China (English)

    李晓峰; 寿标; 等

    1998-01-01

    Speedup is considered as the criterion of determining whether a parallel algorithm is optimal.But broadcast-class problems,existing only on parallel computer system,have no sequential algorithms at all.Speedup standard becomes invalid here.Through this research on broadcast algorithms under several typical prallel computation models,a model-independent evaluation standard min C2 is developed,which can be not only used to determine an optimal broadcasting algorithm,but also normalized to apply to any parallel algorithm.As a new idea,min C2 will lead to a new way in this field.

  7. [Thought on several problems of clinical revaluation of post-marketing herb research].

    Science.gov (United States)

    He, Wei; Xie, Yanming; Wang, Yongyan

    2010-06-01

    The revaluation of post-marketing herb is a complex research work, which concerns widely content and difficult to put it into practice. The starting of our country's revaluation post-marketing herb was comparatively late. It should profect it both in laws and regulations mechanism as well as technological specification. This article is try to focus on some attention problems in revaluation of postmarketing herb process. Such as the laws and regulations demand, the basement and the subject of revaluation of post-marketing herb.

  8. Cell lineage and cell death: Caenorhabditis elegans and cancer research.

    Science.gov (United States)

    Potts, Malia B; Cameron, Scott

    2011-01-01

    Cancer is a complex disease in which cells have circumvented normal restraints on tissue growth and have acquired complex abnormalities in their genomes, posing a considerable challenge to identifying the pathways and mechanisms that drive fundamental aspects of the malignant phenotype. Genetic analyses of the normal development of the nematode Caenorhabditis elegans have revealed evolutionarily conserved mechanisms through which individual cells establish their fates, and how they make and execute the decision to survive or undergo programmed cell death. The pathways identified through these studies have mammalian counterparts that are co-opted by malignant cells. Effective cancer drugs now target some of these pathways, and more are likely to be discovered.

  9. PROBLEM OF RESEARCH OF EMOTIONAL DEVELOPMENT OF MENTALLY RETARDED CHILDREN IN FOREIGN PSYCHOLOGY

    Directory of Open Access Journals (Sweden)

    Larisa Valentinovna Shipova

    2016-02-01

    Full Text Available The review of psychology and pedagogical researches of the mentally retarded children devoted to studying of a problem of emotional development in foreign science and practice is presented in article. Various approaches to an assessment of the importance of violations of the emotional sphere of the personality at mentally retarded children for all mental development of the child are considered, need of the accounting of emotional frustration of mentally retarded children for their education and education, and also social adaptation and integration into sociocultural and educational space is discussed. Research of emotional development of mentally retarded children in the course of training is important for development of programs of psychology and pedagogical diagnostics and correction of emotional violations at this category of school students, formation of their self-control, development of the emotional relations.

  10. Communicating Academic Research Findings to IS Professionals: An Analysis of Problems

    Directory of Open Access Journals (Sweden)

    Michael Lang

    2003-01-01

    Full Text Available Because research findings often do not have direct or immediate relevance to IS professionals in industry, the question arises as to how those findings should be disseminated to them in a suitable form at such time as they do become relevant. A central argument of this paper is that the traditional mechanisms whereby academic researchers disseminate their work are prone to numerous communication breakdowns, and that much work which could potentially make valuable contributions to practice is haplessly lost within the vaults of academia. Using the well-known Shannon & Weaver communication model, three major problems are analyzed: the choice of dissemination channels, language barriers, and the alienation of academia from industry.

  11. Thymic Selection of T-Cell Receptors as an Extreme Value Problem

    Science.gov (United States)

    Kosmrlj, Andrej; Chakraborty, Arup K.; Kardar, Mehran; Shakhnovich, Eugene I.

    2010-03-01

    T lymphocytes (T cells) orchestrate adaptive immune responses that clear pathogens from infected hosts. T cells recognize short peptides (p) derived from foreign proteins, which are bound to major histocompatibility complex (MHC) gene products (displayed on antigen- presenting cells). Recognition occurs when T cell receptor (TCR) proteins expressed on T cells bind sufficiently strongly to antigen- derived pMHC complexes on the surface of antigen-presenting cells. A diverse repertoire of self-tolerant TCR sequences is shaped during development of T cells in the thymus by processes called positive and negative selection. We map thymic selection processes to an extreme value problem and provide analytic expression for the amino acid composition of selected TCR sequences (which enable its recognition functions).

  12. A Research Review of Crime Problems%犯罪问题研究综述

    Institute of Scientific and Technical Information of China (English)

    段丽华

    2012-01-01

      犯罪问题具有普遍性,是长期困扰人类社会的难题之一。文章从宏观和微观角度阐述了国内外研究现状,并详细总结了近几年的研究方法,如数据挖掘、模糊数学、神经网络、灰色系统等。然后,指出了犯罪问题研究中存在的犯罪明数与犯罪暗数问题,最后给出了犯罪问题研究的发展趋势,对犯罪问题研究具有较强的指导意义。%  Crime problems are universal, which have long plagued human society. This article elaborates the current situation of studies both at home and abroad from macroscopic and microscopic angles respectively and summarizes the research methods in recent years in detail, such as data mining, fuzzy mathematics, neural network, gray system. Then this article points out the existing problems concerning light figure of crime and dark figure of crime in the studies on crime problems. Finally this article will play a very important role in guiding future studies by providing the development tendency.

  13. Overhanging Features and the SLM/DMLS Residual Stresses Problem: Review and Future Research Need

    Directory of Open Access Journals (Sweden)

    Albert E. Patterson

    2017-04-01

    Full Text Available A useful and increasingly common additive manufacturing (AM process is the selective laser melting (SLM or direct metal laser sintering (DMLS process. SLM/DMLS can produce full-density metal parts from difficult materials, but it tends to suffer from severe residual stresses introduced during processing. This limits the usefulness and applicability of the process, particularly in the fabrication of parts with delicate overhanging and protruding features. The purpose of this study was to examine the current insight and progress made toward understanding and eliminating the problem in overhanging and protruding structures. To accomplish this, a survey of the literature was undertaken, focusing on process modeling (general, heat transfer, stress and distortion and material models, direct process control (input and environmental control, hardware-in-the-loop monitoring, parameter optimization and post-processing, experiment development (methods for evaluation, optical and mechanical process monitoring, imaging and design-of-experiments, support structure optimization and overhang feature design; approximately 143 published works were examined. The major findings of this study were that a small minority of the literature on SLM/DMLS deals explicitly with the overhanging stress problem, but some fundamental work has been done on the problem. Implications, needs and potential future research directions are discussed in-depth in light of the present review.

  14. Intelligence and Creativity in Problem Solving: The Importance of Test Features in Cognition Research.

    Science.gov (United States)

    Jaarsveld, Saskia; Lachmann, Thomas

    2017-01-01

    This paper discusses the importance of three features of psychometric tests for cognition research: construct definition, problem space, and knowledge domain. Definition of constructs, e.g., intelligence or creativity, forms the theoretical basis for test construction. Problem space, being well or ill-defined, is determined by the cognitive abilities considered to belong to the constructs, e.g., convergent thinking to intelligence, divergent thinking to creativity. Knowledge domain and the possibilities it offers cognition are reflected in test results. We argue that (a) comparing results of tests with different problem spaces is more informative when cognition operates in both tests on an identical knowledge domain, and (b) intertwining of abilities related to both constructs can only be expected in tests developed to instigate such a process. Test features should guarantee that abilities can contribute to self-generated and goal-directed processes bringing forth solutions that are both new and applicable. We propose and discuss a test example that was developed to address these issues.

  15. Intelligence and Creativity in Problem Solving: The Importance of Test Features in Cognition Research

    Science.gov (United States)

    Jaarsveld, Saskia; Lachmann, Thomas

    2017-01-01

    This paper discusses the importance of three features of psychometric tests for cognition research: construct definition, problem space, and knowledge domain. Definition of constructs, e.g., intelligence or creativity, forms the theoretical basis for test construction. Problem space, being well or ill-defined, is determined by the cognitive abilities considered to belong to the constructs, e.g., convergent thinking to intelligence, divergent thinking to creativity. Knowledge domain and the possibilities it offers cognition are reflected in test results. We argue that (a) comparing results of tests with different problem spaces is more informative when cognition operates in both tests on an identical knowledge domain, and (b) intertwining of abilities related to both constructs can only be expected in tests developed to instigate such a process. Test features should guarantee that abilities can contribute to self-generated and goal-directed processes bringing forth solutions that are both new and applicable. We propose and discuss a test example that was developed to address these issues. PMID:28220098

  16. Fuel Cell Research at the University of Delaware

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Jingguang G; Advani, Suresh G

    2006-01-27

    The grant initiated nine basic and applied research projects to improve fundamental understanding and performance of the proton exchange membrane (PEM) fuel cells, to explore innovative methods for hydrogen production and storage, and to address the critical issues and barriers to commercialization. The focus was on catalysis, hydrogen production and storage, membrane durability and flow modeling and characterization of Gas Diffusion Media. Three different types of equipment were purchase with this grant to provide testing and characterization infrastructure for fuel cell research and to provide undergraduate and graduate students with the opportunity to study fuel cell membrane design and operation. They are (i) Arbin Hydrogen cell testing station, (ii) MTS Alliance RT/5 material testing system with an ESPEC custom-designed environmental chamber for membrane Durability Testing and (iii) Chemisorption for surface area measurements of electrocatalysts. The research team included ten faculty members who addressed various issues that pertain to Fuel Cells, Hydrogen Production and Storage, Fuel Cell transport mechanisms. Nine research tasks were conducted to address the critical issues and various barriers to commercialization of Fuel Cells. These research tasks are subdivided in the general areas of (i) Alternative electrocatalysis (ii) Fuel Processing and Hydrogen Storage and (iii) Modeling and Characterization of Membranes as applied to Fuel Cells research.. The summary of accomplishments and approaches for each of the tasks is presented below

  17. On some transmission problems set in a biological cell, analysis and resolution

    Science.gov (United States)

    Labbas, Rabah; Lemrabet, Keddour; Limam, Kheira; Medeghri, Ahmed; Meisner, Maëlis

    2015-10-01

    Some transmission problems are set in bodies with a crown of small thickness ε > 0. For instance, those concerning the conductivity in the biological cell. By a natural change of variables, we transform them in transmission problems set in two cylindrical bodies ] - ∞, 0 [ × ] - π, π [ and ] 0, δ [ × ] - π, π [ (where δ = ln ⁡ (1 + ε)) and then, in some general elliptic abstract differential equations (Pδ) δ > 0. The goal of this work is to give a complete study of these problems (Pδ) δ > 0 for every δ > 0. Existence, uniqueness and maximal regularity results are obtained for the classical solutions essentially by using the semigroups theory.

  18. Cardiac stem cell therapy research in China

    Institute of Scientific and Technical Information of China (English)

    Junbo GE

    2006-01-01

    @@ For more than two decades, the morbidity and mortality of coronary artery disease (CAD) has been increasing rapidly in China. Despite tremendous advances in treatment strategies of CAD, heart failure after acute myocardial infarction (AMI) continues to be one of the greatest medical challenges throughout the world. In 1994, Soonpaa and colleagues first reported the possibility of cardiomyocytes implantation and suggested that intracardiac cell grafting might provide a useful approach for myocardial repair.1 Cell implantation has become a novel therapeutic option for ischemic cardiac injury and heart failure.

  19. Research Progress on the Problem of Fluid, Heat and Energy Distribution near the Earthquake Source Area

    Institute of Scientific and Technical Information of China (English)

    Yan Rui; Jiang Changsheng; Shao Zhigang; Zhou Longquan; Li Yingchun

    2011-01-01

    As the basic problems in seismology, fluid, heat and energy distribution near earthquake sources during earthquake generation have been the leading subjects of concern to seismologists. Currently, more and more research shows fluid around earthquake source areas, which plays an important role in the process of earthquake preparation and generation. However, there is considerable controversy over the source of fluid in the deep crust. As for the problem of heat around earthquake source areas, different models have been proposed to explain the stress heat flow paradox. Among them, the dynamic weakening model has been thought to be the key to solving the heat flow paradox issue. After large earthquakes, energy distribution is directly related to friction heat. It is of timely and important practical significance to immediately implement deep drilling in-site surveying to gain understanding of fluid, friction heat and energy distribution during earthquake generation. The latest international progress in fluid, heat and energy distribution research has been reviewed in this paper which will bring important inspiration for the understanding of earthquake preparation and occurrence.

  20. Persisting problems related to race and ethnicity in public health and epidemiology research

    Directory of Open Access Journals (Sweden)

    Jean-Claude Moubarac

    2013-02-01

    Full Text Available A recent and comprehensive review of the use of race and ethnicity in research that address health disparities in epidemiology and public health is provided. First it is described the theoretical basis upon which race and ethnicity differ drawing from previous work in anthropology, social science and public health. Second, it is presented a review of 280 articles published in high impacts factor journals in regards to public health and epidemiology from 2009-2011. An analytical grid enabled the examination of conceptual, theoretical and methodological questions related to the use of both concepts. The majority of articles reviewed were grounded in a theoretical framework and provided interpretations from various models. However, key problems identified include a a failure from researchers to differentiate between the concepts of race and ethnicity; b an inappropriate use of racial categories to ascribe ethnicity; c a lack of transparency in the methods used to assess both concepts; and d failure to address limits associated with the construction of racial or ethnic taxonomies and their use. In conclusion, future studies examining health disparities should clearly establish the distinction between race and ethnicity, develop theoretically driven research and address specific questions about the relationships between race, ethnicity and health. One argue that one way to think about ethnicity, race and health is to dichotomize research into two sets of questions about the relationship between human diversity and health.

  1. Dendritic cells in melanoma - immunohistochemical study and research trends.

    Science.gov (United States)

    Nedelcu, Roxana Ioana; Ion, Daniela Adriana; Holeab, Cosmin Adrian; Cioplea, Mirela Daniela; Brînzea, Alice; Zurac, Sabina Andrada

    2015-01-01

    Cutaneous dendritic cells play multiple physiological roles and are involved in various pathophysiological processes. Research studies of dendritic cells abound in the medical literature. Nevertheless, the role of dendritic cells in melanoma regression phenomenon is not completely understood. We conducted a scientometric analysis in order to highlight the current state on research regarding dendritic cells and melanoma. We also performed an immunohistochemical study, using specific markers for dendritic cells (CD1a, langerin). We evaluated the frequency and distribution of dendritic cells in areas of tumor regression compared to the areas of inflammatory infiltrate of melanoma without regression. The immunohistochemical study we performed revealed that dendritic cells are more frequent in the regressed areas, comparing with non-regressed ones. In regressed areas, dendritic cells have a predominant nodular pattern (19 cases), followed by diffuse isolate pattern (eight cases) and mixed pattern (diffuse and nodular) (three cases). In melanoma without regression, most cases presented a diffuse pattern (27 cases) of dendritic cells distribution. In conclusion, our immunohistochemical study stressed differences between frequency and distribution of dendritic cells located in the melanoma with regression and melanoma without regression. These data suggest that dendritic cells are involved in the regression phenomenon. Following the literature analysis we obtained, we observed that dendritic cells profile in melanoma with regression was poorly studied. Insights into antitumor immune response and dendritic cells may be essential for the understanding of the potential prognostic role of dendritic cells in melanoma and for the development of new promising therapeutic strategies for melanoma.

  2. The ethics of moral compromise for stem cell research policy.

    Science.gov (United States)

    Master, Zubin; Crozier, G K D

    2012-03-01

    In the US, stem cell research is at a moral impasse-many see this research as ethically mandated due to its potential for ameliorating major diseases, while others see this research as ethically impermissible because it typically involves the destruction of embryos and use of ova from women. Because their creation does not require embryos or ova, induced pluripotent stem cells offer the most promising path for addressing the main ethical objections to stem cell research; however, this technology is still in development. In order for scientists to advance induced pluripotent stem cell research to a point of translational readiness, they must continue to use ova and embryos in the interim. How then are we to ethically move forward with stem cell research? We argue that there is personal integrity and value in adopting a 'moral compromise' as a means for moving past the moral impasse in stem cell research. In a moral compromise, each party concedes part of their desired outcome in order to engage in a process that respects the values and desires of all parties equitably. Whereas some contend that moral compromise in stem cell research necessarily involves self-contradiction or loss of personal integrity, we argue that in the US context, stem cell research satisfies many of the key pre-conditions of an effective moral compromise. To illustrate our point, we offer a model solution wherein eggs and embryos are temporarily used until non-egg and non-embryonic sources of pluripotent stem cells are developed to a state of translational readiness.

  3. Fuel cell research: Towards efficient energy

    CSIR Research Space (South Africa)

    Rohwer, MB

    2008-11-01

    Full Text Available .3 of this paper, and ranked the alcohols in terms of reactivity (i.e. power output from the cell) as follows: ethylene glycol > glycerol > methanol > erythritol > xylitol. We conducted a similar study, using a commercial PEM DMFC to evaluate...

  4. Pluripotent stem cell-derived neural stem cells: From basic research to applications

    Institute of Scientific and Technical Information of China (English)

    Masahiro; Otsu; Takashi; Nakayama; Nobuo; Inoue

    2014-01-01

    Basic research on pluripotent stem cells is designed to enhance understanding of embryogenesis, whereas applied research is designed to develop novel therapies and prevent diseases. Attainment of these goals has been enhanced by the establishment of embryonic stem cell lines, the technological development of genomic reprogramming to generate induced-pluripotent stem cells, and improvements in in vitro techniques to manipulate stem cells. This review summarizes the techniques required to generate neural cells from pluripotent stem cells. In particular, this review describes current research applications of a simple neural differentiation method, the neural stem sphere method, which we developed.

  5. Stem cells have the potential to rejuvenate regenerative medicine research.

    Science.gov (United States)

    Eve, David J; Fillmore, Randolph; Borlongan, Cesar V; Sanberg, Paul R

    2010-10-01

    The increasing number of publications featuring the use of stem cells in regenerative processes supports the idea that they are revolutionizing regenerative medicine research. In an analysis of the articles published in the journal Cell Transplantation - The Regenerative Medicine Journal between 2008 and 2009, which reveals the topics and categories that are on the cutting edge of regenerative medicine research, stem cells are becoming increasingly relevant as the "runner-up" category to "neuroscience" related articles. The high volume of stem cell research casts a bright light on the hope for stem cells and their role in regenerative medicine as a number of reports deal with research using stem cells entering, or seeking approval for, clinical trials. The "methods and new technologies" and "tissue engineering" sections were almost equally as popular, and in part, reflect attempts to maximize the potential of stem cells and other treatments for the repair of damaged tissue. Transplantation studies were again more popular than non-transplantation, and the contribution of stem cell-related transplants was greater than other types of transplants. The non-transplantation articles were predominantly related to new methods for the preparation, isolation and manipulation of materials for transplant by specific culture media, gene therapy, medicines, dietary supplements, and co-culturing with other cells and further elucidation of disease mechanisms. A sizeable proportion of the transplantation articles reported on how previously new methods may have aided the ability of the cells or tissue to exert beneficial effects following transplantation.

  6. The Usefulness of Qualitative and Quantitative Approaches and Methods in Researching Problem-Solving Ability in Science Education Curriculum

    Science.gov (United States)

    Eyisi, Daniel

    2016-01-01

    Research in science education is to discover the truth which involves the combination of reasoning and experiences. In order to find out appropriate teaching methods that are necessary for teaching science students problem-solving skills, different research approaches are used by educational researchers based on the data collection and analysis…

  7. Review of Research for People with ID and Mental Health Problems: A View from the United Kingdom

    Science.gov (United States)

    Hemmings, Colin; Deb, Shoumitro; Chaplin, Eddie; Hardy, Steve; Mukherjee, Rittick

    2013-01-01

    This review of research into mental disorders in people with intellectual disabilities (ID) focuses on research in this field that has originated from the United Kingdom in the last 2 decades. It considers research developments into the epidemiology of mental disorders and problem behaviors, psychopharmacology, psychosocial interventions, and…

  8. Review of Research for People with ID and Mental Health Problems: A View from the United Kingdom

    Science.gov (United States)

    Hemmings, Colin; Deb, Shoumitro; Chaplin, Eddie; Hardy, Steve; Mukherjee, Rittick

    2013-01-01

    This review of research into mental disorders in people with intellectual disabilities (ID) focuses on research in this field that has originated from the United Kingdom in the last 2 decades. It considers research developments into the epidemiology of mental disorders and problem behaviors, psychopharmacology, psychosocial interventions, and…

  9. Promises and challenges of stem cell research for regenerative medicine.

    Science.gov (United States)

    Power, Carl; Rasko, John E J

    2011-11-15

    In recent years, stem cells have generated increasing excitement, with frequent claims that they are revolutionizing medicine. For those not directly involved in stem cell research, however, it can be difficult to separate fact from fiction or realistic expectation from wishful thinking. This article aims to provide internists with a clear and concise introduction to the field. While recounting some scientific and medical milestones, the authors discuss the 3 main varieties of stem cells-adult, embryonic, and induced pluripotent-comparing their advantages and disadvantages for clinical medicine. The authors have sought to avoid the moral and political debates surrounding stem cell research, focusing instead on scientific and medical issues.

  10. A Sokhotski-Plemelj problem related to a renewable T-cell

    African Journals Online (AJOL)

    2005-08-08

    Aug 8, 2005 ... Therefore, human inspections are indispensable in attempts at ..... cell, IEEE Transactions on Robotics and Automation, 12, pp. 1–13. [5] Dhillon BS ... times, European Journal of Operational Research, 139, pp. 96–114.

  11. Problem Types in Synthetic Organic Chemistry Research: Implications for the Development of Curricular Problems for Second-Year Level Organic Chemistry Instruction

    Science.gov (United States)

    Raker, Jeffrey R.; Towns, Marcy H.

    2012-01-01

    Understanding of the nature of science is key to the development of new curricular materials that mirror the practice of science. Three problem types (project level, synthetic planning, and day-to-day) in synthetic organic chemistry emerged during a thematic content analysis of the research experiences of eight practising synthetic organic…

  12. Bioethics and the Stem Cell Research Debate

    Science.gov (United States)

    Shapiro, Robyn S.

    2006-01-01

    Bioethics--the study of ethical issues in science and medicine--has grown to become a significant academic and service-oriented discipline with its own research centers, conferences, journals, and degree programs. As these issues have moved to the center of public debate, the law has assumed an increasingly important place in the discipline of…

  13. Bioethics and the Stem Cell Research Debate

    Science.gov (United States)

    Shapiro, Robyn S.

    2006-01-01

    Bioethics--the study of ethical issues in science and medicine--has grown to become a significant academic and service-oriented discipline with its own research centers, conferences, journals, and degree programs. As these issues have moved to the center of public debate, the law has assumed an increasingly important place in the discipline of…

  14. Amniotic fluid-derived stem cells in regenerative medicine research.

    Science.gov (United States)

    Joo, Sunyoung; Ko, In Kap; Atala, Anthony; Yoo, James J; Lee, Sang Jin

    2012-02-01

    The stem cells isolated from amniotic fluid present an exciting possible contribution to the field of regenerative medicine and amniotic fluid-derived stem (AFS) cells have significant potential for research and therapeutic applications. AFS cells are multipotent, showing the ability to differentiate into cell types from all three embryonic germ layers. They express both embryonic and adult stem cell markers, expand extensively without feeder cells, double in 36 h, and are not tumorigenic. The AFS cells can be maintained for over 250 population doublings and preserve their telomere length and a normal karyotype. They differentiate easily into specific cell lineages and do not require human embryo tissue for their isolation, thus avoiding the current controversies associated with the use of human embryonic stem (ES) cells. The discovery of the AFS cells has been recent, and a great deal of work remains to be performed on the characterization and use of these cells. This review describes the various differentiated lineages that AFS cells can form and the future of these promising new stem cells in regenerative medicine research.

  15. Sequencing technologies for animal cell culture research.

    Science.gov (United States)

    Kremkow, Benjamin G; Lee, Kelvin H

    2015-01-01

    Over the last 10 years, 2nd and 3rd generation sequencing technologies have made the use of genomic sequencing within the animal cell culture community increasingly commonplace. Each technology's defining characteristics are unique, including the cost, time, sequence read length, daily throughput, and occurrence of sequence errors. Given each sequencing technology's intrinsic advantages and disadvantages, the optimal technology for a given experiment depends on the particular experiment's objective. This review discusses the current characteristics of six next-generation sequencing technologies, compares the differences between them, and characterizes their relevance to the animal cell culture community. These technologies are continually improving, as evidenced by the recent achievement of the field's benchmark goal: sequencing a human genome for less than $1,000.

  16. Three-Dimensional Problems of Thermoviscoplasticity: Focus on Ukrainian Research (Review)

    Science.gov (United States)

    Shevchenko, Yu. N.; Savchenko, V. G.

    2016-05-01

    Methods and results of studying the three-dimensional viscoplastic stress-strain state of engineering structures under thermomechanical loading are presented. The following classes of thermoviscoelastic problems are considered: axisymmetric problems, nonaxisymmetric problems for bodies of revolution, three-dimensional problems for arbitrarily shaped bodies, three-dimensional problems for isotropic and anisotropic bodies of revolution

  17. CONCEPTUALIZATION OF IDEAS OF PSYCHOLOGICAL SAFETY IN SPORTS: PROBLEMS OF EXPERIMENTAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Yulia Vladimirovna Vardanyan

    2013-09-01

    Full Text Available This article is devoted to the research of the concept “psychological safety in sports”. On the basis of analysis of ideas about psychological safety in sports and their representation in printed or verbal form the necessity of overcoming the fragmentation and lack of system is substantiated. The authors state that one and the same sports situation can constructively or destructively affect the psychological safety of direct or indirect participants of sports events. In this context, it is important to create the psycholinguistic basis of experimental research of psychological safety in sports. Great attention is paid to systematization of the content of the concept “psychological safety in sports”. The created models of words and expressions that convey ideas about this phenomenon are of particular value. In the structure of the concept the dominant meanings, expressed in the nucleus, and additional meanings, related to the periphery of the concept are distinguished.Purpose: to explore the ideas of psychological safety in sports and their representation in printed or verbal form; to determine ways of overcoming the conceptual psycholinguistic problems in the process of experimental research of psychological safety in sports; to create the model of words and expressions which are used to verbalize the concept “psychological safety in sports”.Methodology: theoretical analysis of psychological and linguistic literature, creation of the psycholinguistic basis of experimental research, modeling of the conceptual ideas of psychological safety in sports.Results: psycholinguistic basis of experimental research of psychological safety in sports, the model of content and structure of the corresponding concept.Practical implications: Pedagogical Psychology, Sports Psychology, Philology, Psycholinguistics.DOI: http://dx.doi.org/10.12731/2218-7405-2013-8-11

  18. Temas e problemas nos projetos de pesquisa Thems and problems in research projects

    Directory of Open Access Journals (Sweden)

    Alvaro Bianchi

    2007-05-01

    Full Text Available O ponto de partida da atividade cienífica é o espanto e a admiração perante o desconhecido que provocam a imaginação científica, conduzindo o investigador à escolha de uma dada temática. Relevância para o mundo real e contribuição para um campo específico do conhecimento são, aqui, critérios de definição temática. Para o cientista, o tema de pesquisa é o terreno sobre o qual ele formulará problemas relevantes de investigação capazes de suprir lacunas em nossos conhecimentos. Tais problemas devem ser construídos de tal maneira que suas soluções não só esclareçam aspectos até então não explicados do tema, como apontem para novos problemas, ou seja, futuras investigações científicas. Constatando a crescente exigência de monografias de conclusão de curso para a obtenção de título nos cursos de graduação, o artigo procura construir um guia para a definição de temas e a formulação de pesquisa nas ciências humanas. Para tanto, procederá a uma reconstrução metodológica do caminho percorrido por C. Wright Mills em sua obra The power elite. Palavras-chave: Metodologia da pesquisa. Pesquisa cientifica. Problemas científicos. The starting point of the scientific activity is the puzzle and admiration in face of the unknown, which, certainly, will challenge the scientific imagination, leading the researcher in the choice of a certain theme. Relevance for the real world and contribution for a specific field of knowledge are the basic criteria for the thematic definition used here. For the scientist, the theme of the research is the base to formulate relevant research problems able to fill in the gaps of our knowledge. Such problems must be built in such a way that is solutions will not only clarify some aspects of the theme that remained not explained but also provide a path for new questions, i.e., for new scientifc researches to come. As there is a growing demand of under-graduate monographs for

  19. Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.

    Directory of Open Access Journals (Sweden)

    Paolo Cremaschi

    Full Text Available Moderate DNA damage resulting from metabolic activities or sub-lethal doses of exogenous insults may eventually lead to cancer onset. Human 46BR.1G1 cells bear a mutation in replicative DNA ligase I (LigI which results in low levels of replication-dependent DNA damage. This replication stress elicits a constitutive phosphorylation of the ataxia telangiectasia mutated (ATM checkpoint kinase that fails to arrest cell cycle progression or to activate apoptosis or cell senescence. Stable transfection of wild type LigI, as in 7A3 cells, prevents DNA damage and ATM activation. Here we show that parental 46BR.1G1 and 7A3 cells differ in important features such as cell morphology, adhesion and migration. Comparison of gene expression profiles in the two cell lines detects Bio-Functional categories consistent with the morphological and migration properties of LigI deficient cells. Interestingly, ATM inhibition makes 46BR.1G1 more similar to 7A3 cells for what concerns morphology, adhesion and expression of cell-cell adhesion receptors. These observations extend the influence of the DNA damage response checkpoint pathways and unveil a role for ATM kinase activity in modulating cell biology parameters relevant to cancer progression.

  20. Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.

    Science.gov (United States)

    Cremaschi, Paolo; Oliverio, Matteo; Leva, Valentina; Bione, Silvia; Carriero, Roberta; Mazzucco, Giulia; Palamidessi, Andrea; Scita, Giorgio; Biamonti, Giuseppe; Montecucco, Alessandra

    2015-01-01

    Moderate DNA damage resulting from metabolic activities or sub-lethal doses of exogenous insults may eventually lead to cancer onset. Human 46BR.1G1 cells bear a mutation in replicative DNA ligase I (LigI) which results in low levels of replication-dependent DNA damage. This replication stress elicits a constitutive phosphorylation of the ataxia telangiectasia mutated (ATM) checkpoint kinase that fails to arrest cell cycle progression or to activate apoptosis or cell senescence. Stable transfection of wild type LigI, as in 7A3 cells, prevents DNA damage and ATM activation. Here we show that parental 46BR.1G1 and 7A3 cells differ in important features such as cell morphology, adhesion and migration. Comparison of gene expression profiles in the two cell lines detects Bio-Functional categories consistent with the morphological and migration properties of LigI deficient cells. Interestingly, ATM inhibition makes 46BR.1G1 more similar to 7A3 cells for what concerns morphology, adhesion and expression of cell-cell adhesion receptors. These observations extend the influence of the DNA damage response checkpoint pathways and unveil a role for ATM kinase activity in modulating cell biology parameters relevant to cancer progression.

  1. The New Federalism: State Policies Regarding Embryonic Stem Cell Research.

    Science.gov (United States)

    Acosta, Nefi D; Golub, Sidney H

    2016-09-01

    Stem cell policy in the United States is an amalgam of federal and state policies. The scientific development of human pluripotent embryonic stem cells (ESCs) triggered a contentious national stem cell policy debate during the administration of President George W. Bush. The Bush "compromise" that allowed federal funding to study only a very limited number of ESC derived cell lines did not satisfy either the researchers or the patient advocates who saw great medical potential being stifled. Neither more restrictive legislation nor expansion of federal funding proved politically possible and the federal impasse opened the door for a variety of state-based experiments. In 2004, California became the largest and most influential state venture into stem cell research by passing "Prop 71," a voter initiative that created a new stem cell agency and funded it with $3 billion. Several states followed suit with similar programs to protect the right of investigators to do stem cell research and in some cases to invest state funding in such projects. Other states devised legislation to restrict stem cell research and in five states, criminal penalties were included. Thus, the US stem cell policy is a patchwork of multiple, often conflicting, state and federal policies.

  2. The ethical dilemma of embryonic stem cell research.

    Science.gov (United States)

    Manzar, Nabeel; Manzar, Bushra; Hussain, Nuzhat; Hussain, M Fawwad Ahmed; Raza, Sajjad

    2013-03-01

    To determine the knowledge, attitude, and ethical concerns of medical students and graduates with regard to Embryonic Stem Cell (ESC) research. This questionnaire based descriptive study was conducted at the Civil Hospital Karachi (CHK), Pakistan from February to July 2008. A well structured questionnaire was administered to medical students and graduate doctors, which included their demographic profile as well as questions in line with the study objective. Informed consent was taken and full confidentiality was assured to the participants. Data were entered in a Statistical Package for Social Sciences (SPSS version.12) and analyzed. A total of 204 male and 216 female medical students and doctors were administered questionnaires out of which 105 males (51.4%) and 108 females (50%) were aware of the embryonic stem cell research and its ethical implications. Forty percent males and 47% of females were of the opinion that life begins at conception. Forty-six percent males and 39% females were in favor of stem cell research while only 31% males and 28% females supported the ESC research. Less than 1/3 of students supported using frozen embryos for research purposes while more than 2/3 indicated that they were unlikely to support abortion for stem cell research purposes. The majority of the students were in favor of stem cell research with some reservations regarding ESC research. A sizeable number of students withheld their views, reflecting their poor understanding of medical ethics. The result of the study indicates a need for incorporating bioethics into the medical curriculum.

  3. Managing Ethical Problems in Qualitative Research Involving Vulnerable Populations, Using a Pilot Study

    Directory of Open Access Journals (Sweden)

    Evalina van Wijk RN, PhD

    2013-02-01

    Full Text Available The purpose of the researcher's study was to examine the meaning that intimate partners of female rape victims attached to their lived experiences after the rape. The conduct of qualitative research concerning non-offending partners of female rape victims, however, often involves multifaceted ethical and practical challenges, which can be managed through the use of pilot studies. The pilot study described in this report had three objectives. The first was to pretest and refine the proposed method for locating, accessing, and recruiting intimate partners of female rape victims, within the first two weeks after the rape, for participation in a six-month longitudinal study. The second objective was to identify and prevent all possible risk factors in the proposed recruitment and data collection methods that could harm the participants' safety during the main study. The third objective was to determine the feasibility of the main study, in terms of the limited financial and human resources available. The pilot phase was valuable in identifying ethical and methodological problems during the recruitment of participants and collection of data. It allowed for methodological adjustments prior to the main study and confirmed the feasibility of the overall research design. A pilot, pretesting phase is therefore seen as an essential component of a qualitative study involving a vulnerable population.

  4. An open data ecosystem for cell migration research

    NARCIS (Netherlands)

    Masuzzo, P.; Martens, L.; Ampe, C.; Anderson, K.I.; Barry, J.; Wever, O. De; Debeir, O.; Decaestecker, C.; Dolznig, H.; Friedl, P.H.A.; Gaggioli, C.; Geiger, B.; Goldberg, I.G.; Horn, E.; Horwitz, R.; Kam, Z.; Devedec, S.E. Le; Vignjevic, D.M.; Moore, J.; Olivo-Marin, J.C.; Sahai, E.; Sansone, S.A.; Sanz-Moreno, V.; Stromblad, S.; Swedlow, J.; Textor, J.C.; Troys, M. Van; Zantl, R.

    2015-01-01

    Cell migration research has recently become both a high content and a high throughput field thanks to technological, computational, and methodological advances. Simultaneously, however, urgent bioinformatics needs regarding data management, standardization, and dissemination have emerged. To address

  5. An open data ecosystem for cell migration research

    NARCIS (Netherlands)

    Masuzzo, P.; Martens, L.; Ampe, C.; Anderson, K.I.; Barry, J.; Wever, O. De; Debeir, O.; Decaestecker, C.; Dolznig, H.; Friedl, P.H.A.; Gaggioli, C.; Geiger, B.; Goldberg, I.G.; Horn, E.; Horwitz, R.; Kam, Z.; Devedec, S.E. Le; Vignjevic, D.M.; Moore, J.; Olivo-Marin, J.C.; Sahai, E.; Sansone, S.A.; Sanz-Moreno, V.; Stromblad, S.; Swedlow, J.; Textor, J.C.; Troys, M. Van; Zantl, R.

    2015-01-01

    Cell migration research has recently become both a high content and a high throughput field thanks to technological, computational, and methodological advances. Simultaneously, however, urgent bioinformatics needs regarding data management, standardization, and dissemination have emerged. To address

  6. Problem-Solving Test: RNA and Protein Synthesis in Bacteriophage-Infected "E. coli" Cells

    Science.gov (United States)

    Szeberenyi, Jozsef

    2008-01-01

    The classic experiment presented in this problem-solving test was designed to identify the template molecules of translation by analyzing the synthesis of phage proteins in "Escherichia coli" cells infected with bacteriophage T4. The work described in this test led to one of the most seminal discoveries of early molecular biology: it dealt a…

  7. Problem-Solving Test: RNA and Protein Synthesis in Bacteriophage-Infected "E. coli" Cells

    Science.gov (United States)

    Szeberenyi, Jozsef

    2008-01-01

    The classic experiment presented in this problem-solving test was designed to identify the template molecules of translation by analyzing the synthesis of phage proteins in "Escherichia coli" cells infected with bacteriophage T4. The work described in this test led to one of the most seminal discoveries of early molecular biology: it dealt a…

  8. Stem cell research in stroke: how far from the clinic?

    Science.gov (United States)

    Lindvall, Olle; Kokaia, Zaal

    2011-08-01

    Stem cell-based approaches hold much promise as potential novel treatments to restore function after stroke. Studies in animal models have shown that stem cell transplantation can improve function by replacing neurons or by trophic actions, modulation of inflammation, promotion of angiogenesis, remyelination and axonal plasticity, and neuroprotection. Endogenous neural stem cells are also potential therapeutic targets because they produce new neurons after stroke. Clinical trials are ongoing but there is currently no proven stem cell-based therapy for stroke. Preclinical studies and clinical research will be needed to optimize the therapeutic benefit and minimize the risks of stem cells in stroke.

  9. Stem cells: basic research on health, from ethics to panacea

    Directory of Open Access Journals (Sweden)

    Naara Luna

    2007-01-01

    Full Text Available Even though stem cell therapies are still under experimentation, the media has represented them as a panacea that would cure all diseases. This fact secured the authorization for using human embryos as research material. Therapies include manipulation of human material in tissue bioengineering, suggesting a representation of the body as a factory. This article describes stem cell research projects being carried out in the health sciences center of a higher education institution, focusing on field organization and on the system of values underlying scientific activity. Researchers at different levels were interviewed about perspectives on, and implications of, their research in order to analyze the discourse of the projects' participants. Experiments with adult stem cells enjoyed wide support, while the use of human embryos was disputed. The foundations of those arguments were sought in their relation both to the structure of the scientific field and to the researchers' religious background.

  10. Ethical issues of the research on human embryonic stem cells.

    Science.gov (United States)

    Hotta, Yoshitaro

    2008-09-01

    This paper examines the debate on human embryonic stem cell (hES) research. In Japan, as in many Western countries, the moral status of the human embryo has been the main focus. There is a dichotomy between the advocates of research on hES cells and the advocates of the dignity of the embryos. Advocates of research on hES cells claim that the act of abandoning the embryo and the act of using it for research have the same moral status. Critics of research using embryos reject this position, claiming that the embryo has a status incommensurable with other values. This paper points out that the standpoint of the woman providing the embryos has been overlooked in this discussion.

  11. WebMail versus WebApp: Comparing Problem-Based Learning Methods in a Business Research Methods Course

    Science.gov (United States)

    Williams van Rooij, Shahron

    2007-01-01

    This study examined the impact of two Problem-Based Learning (PBL) approaches on knowledge transfer, problem-solving self-efficacy, and perceived learning gains among four intact classes of adult learners engaged in a group project in an online undergraduate business research methods course. With two of the classes using a text-only PBL workbook…

  12. Training Interdisciplinary "Wicked Problem" Solvers: Applying Lessons from HERO in Community-Based Research Experiences for Undergraduates

    Science.gov (United States)

    Cantor, Alida; DeLauer, Verna; Martin, Deborah; Rogan, John

    2015-01-01

    Management of "wicked problems", messy real-world problems that defy resolution, requires thinkers who can transcend disciplinary boundaries, work collaboratively, and handle complexity and obstacles. This paper explores how educators can train undergraduates in these skills through applied community-based research, using the example of…

  13. Proceedings of the workshop on hydrocarbon processing mixing and scale-up problems. [Fuels processing for fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Gabor, J. D. [ed.

    1978-01-01

    A workshop was convened by the Division of Fossil Fuel Utilization of the US Department of Energy in cooperation with the Particulate and Multiphase Process Program of the National Science Foundation to identify needs for fundamental engineering support for the design of chemical reactors for processing heavy hydrocarbon liquids. The problems associated with dispersing liquid hydrocarbons in a reacting gas and mixing within the gas phase are of primary concern. The transactions of the workshop begin with an introduction to the immediate goals of the Department of Energy. Fuel cell systems and current research and development are reviewed. Modeling of combustion and the problems of soot formation and deposits in hydrocarbon fuels are next considered. The fluid mechanics of turbulent mixing and its effect on chemical reactions are then presented. Current experimental work and process development provide an update on the present state-of-the-art.

  14. HESS Opinions "Integration of groundwater and surface water research: an interdisciplinary problem?"

    Directory of Open Access Journals (Sweden)

    R. Barthel

    2014-02-01

    Full Text Available Today there is a great consensus that water resources research needs to become more holistic, integrating perspectives of a large variety of disciplines. Groundwater and surface water (hereafter: GW and SW are typically identified as different compartments of the hydrological cycle and were traditionally often studied and managed separately. However, despite this separation, these respective fields of study are usually not considered to be different disciplines. They are often seen as different specialisations of hydrology with different focus, yet similar theory, concepts, methodology. The present article discusses how this notion may form a substantial obstacle in the further integration of GW and SW research and management. The article focusses on the regional scale (areas of approx. 103 to 106 km2, which is identified as the scale where integration is most greatly needed, but ironically the least amount of fully integrated research seems to be undertaken. The state of research on integrating GW and SW research is briefly reviewed and the most essential differences between GW hydrology (or hydrogeology, geohydrology and SW hydrology are presented. Groundwater recharge and baseflow are used as examples to illustrate different perspectives on similar phenomena that can cause severe misunderstandings and errors in the conceptualisation of integration schemes. It is also discussed that integration of GW and SW research on the regional scale necessarily must move beyond the hydrological aspects, by collaborating with social sciences and increasing the interaction between science and the society in general. The typical elements of an ideal interdisciplinary workflow are presented and their relevance with respect to integration of GW and SW is discussed. The overall conclusions are that GW hydrology and SW hydrogeology study rather different objects of interest, using different types of observation, working on different problem settings. They have

  15. The rising tide of ocean diseases: Unsolved problems and research priorities

    Science.gov (United States)

    Harvell, Drew; Aronson, Richard; Baron, Nancy; Connell, Joseph; Dobson, Andrew P.; Ellner, Steve; Gerber, Leah R.; Kim, Kiho; Kuris, Armand M.; McCallum, Hamish; Lafferty, Kevin D.; McKay, Bruce; Porter, James; Pascual, Mercedes; Smith, Garriett; Sutherland, Katherine; Ward, Jessica

    2004-01-01

    New studies have detected a rising number of reports of diseases in marine organisms such as corals, molluscs, turtles, mammals, and echinoderms over the past three decades. Despite the increasing disease load, microbiological, molecular, and theoretical tools for managing disease in the world's oceans are under-developed. Review of the new developments in the study of these diseases identifies five major unsolved problems and priorities for future research: (1) detecting origins and reservoirs for marine diseases and tracing the flow of some new pathogens from land to sea; (2) documenting the longevity and host range of infectious stages; (3) evaluating the effect of greater taxonomic diversity of marine relative to terrestrial hosts and pathogens; (4) pinpointing the facilitating role of anthropogenic agents as incubators and conveyors of marine pathogens; (5) adapting epidemiological models to analysis of marine disease.

  16. Applying Ant Colony Optimization to the Problem of Cell Planning in Mobile Telephone System Radio Network

    Directory of Open Access Journals (Sweden)

    Osmar Viera Carcache

    2017-03-01

    Full Text Available This paper presents a computational proposal for the solution of the Cell Planning Problem. The importance of this problem in the area of Telecommunications imposes it as a reference in the search for new methods of optimization. Due to the complexity of the problem, this work uses a discrete relaxation and proposes a mathematical model for the application of the Meta-heuristic Ant Colony Optimization (ACO. For the analysis of the results, 5 instances of the problem of different sizes were selected and the Ants System (AS algorithm was applied. The results show that the proposal efficiently explores the search space, finding the optimal solution for each instance with a relatively low computational cost. These results are compared with 3 evolutionary alternatives of international reference that have been applied to the same study instances, showing a significant improvement by our proposal.

  17. Research

    Science.gov (United States)

    Mathematics Teaching, 1973

    1973-01-01

    Implications for teachers from Piagetian-oriented piagetian-oriented research on problem solving reported in an article by Eleanor Duckworth are presented. Edward de Bono's Children Solve Problems,'' a collection of examples, is also discussed. (MS)

  18. Applications of carbon nanotubes in stem cell research.

    Science.gov (United States)

    Ramón-Azcón, Javier; Ahadian, Samad; Obregón, Raquel; Shiku, Hitoshi; Ramalingam, Murugan; Matsue, Tomokazu

    2014-10-01

    Stem cells are a key element in tissue engineering and regenerative medicine. However, they require a suitable microenvironment to grow and regenerate. Carbon nanotubes (CNTs) have attracted much attention as promising materials for stem cell research due to their extraordinary properties, such as their extracellular matrix-like structure, high mechanical strength, optical properties, and high electrical conductivity. Of particular interest is the use of CNTs as biomimetic substrates to control the differentiation of stem cells. CNTs have also been combined with commonly used scaffolds to fabricate functional scaffolds to direct stem cell fate. CNTs can also be used for stem cell labeling due to their high optical absorbance in the near-infrared regime. In this paper, we review and discuss the applications of CNTs in stem cell research along with CNT toxicity issues.

  19. Assessing Risks to Wildlife Populations from Multiple Stressors: Overview of the Problem and Research Needs.

    Directory of Open Access Journals (Sweden)

    Wayne R. Munns, Jr.

    2006-06-01

    Full Text Available Wildlife populations are experiencing increasing pressure from human-induced changes in the landscape. Stressors including agricultural and urban land use, introduced invasive and exotic species, nutrient enrichment, direct human disturbance, and toxic chemicals directly or indirectly influence the quality and quantity of habitat used by terrestrial and aquatic wildlife. Governmental agencies such as the U.S. Environmental Protection Agency are required to assess risks to wildlife populations, in its broadest definition, that result from exposure to these stressors, yet considerable uncertainty exists with respect to how such assessments should be conducted. This uncertainty is compounded by questions concerning the interactive effects of co-occurring stressors, appropriate spatial scales of analysis, extrapolation of response data among species and from organisms to populations, and imperfect knowledge and use of limited data sets. Further, different risk problems require varying degrees of sophistication, methodological refinement, and data quality. These issues suggest a number of research needs to improve methods for wildlife risk assessments, including continued development of population dynamics models to evaluate the effects of multiple stressors at varying spatial scales, methods for extrapolating across endpoints and species with reasonable confidence, stressor-response relations and methods for combining them in predictive and diagnostic assessments, and accessible data sets describing the ecology of terrestrial and aquatic species. Case study application of models and methods for assessing wildlife risk will help to demonstrate their strengths and limitations for solving particular risk problems.

  20. Problem solving in physics: research review, analysis, and a methodological proposal

    Directory of Open Access Journals (Sweden)

    Maria Helena Fávero

    2001-05-01

    Full Text Available This article presents a literature review on problem solving in Physics based on the scientific articles published in periodicals of the related field of study. The articles considered for this study were published in the period between the end of the 70`s until 1999. A categorization of the publications , according to the issue investigated, the theoretical background used, the research method adopted, the results and conclusions are considered as a starting point in order to present a research profile of the field of study. Next, this profile is discussed and analyzed , pointing out the convergent aspects that characterize the field. Taking this analysis into account, the following thesis (based on Fávero`s proposal, 2000 is defended: in order to generate tools for the teaching practice of Physics through the study of problem solving, a method that substitutes the idea of knowledge transmission in the communication processes that takes place in the classroom should be developed. This method should comprise the idea of interlocution (Vion, 2000 which focuses on social interaction as a means to reveal metacognitive regulations of the subjects, pariticipants in the process, and their development of awareness in relation to a conceptual field (Vergnaud, 1990 – Physics, in this case. The analysis of these processes considers the verbal exchanges among the subjects (Bromberg & Chabrol, 1999 developed in the situation of interaction. This thesis is supported by the articulation of concepts in Psychology, including its interface with linguistics, such as conceptual field, development of awareness and acts of speech, which are reconsidered in this study.

  1. SULFUR DIOXIDE - SULFUR TRIOXIDE REGENERATIVE FUEL CELL RESEARCH

    Science.gov (United States)

    The thermodynamics and electrolytic characteristics are discussed of an SO2-SO3 regenerative, closed-cycle fuel cell , and summarizes the electrolytic...electrochemical, and phase separation research conducted during a study program to determine the practicability of such a fuel cell . The...experimental results obtained were at such wide variance with the theoretical concept that it became apparent that a fuel cell of this type is not feasible. (Author)

  2. Translational Research on Esophageal Cancer: From Cell Line to Clinic

    NARCIS (Netherlands)

    J.J. Boonstra (Jurjen)

    2011-01-01

    textabstractWorldwide esophageal cancer is a signifi cant and an increasing health problem. In 2005, there were 497,700 new cases, and the prevalence is expected to increase by approximately 140% by 2025. Esophageal squamous cell carcinoma (ESCC) accounts for most of the cases of esophageal cancer w

  3. Proceedings of the Queen's-RMC Fuel Cell Research Centre fuel cell technology day

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The Queen's-RMC Fuel Cell Research Centre was formed to conduct research on polymer electrolyte membrane (PEM) and solid oxide (SOFC) fuel cells as well as fuel processing and hydrogen production and storage technologies. The centre focuses on the development of manufacturing methods, mathematical modelling, catalysis and reaction engineering, and computational thermodynamics. The fuel cell technology day provided a forum for research leaders from various institutions to discuss recent studies related to PEM and SOFC fuel cells. Issues related to materials and system degradation in fuel cells were discussed along with recent developments in the micro-engineering of SOFC cathodes. Commercialization plans for megawatt fuel cells were also discussed, and recent spectroscopy and voltammetry studies of PEM fuel cells were presented. A panel discussion was also held to determine research directions for the future. The technology day featured 7 presentations, of which 2 have been catalogued separately for inclusion in this database. tabs., figs.

  4. Measuring Human Performance on Clustering Problems: Some Potential Objective Criteria and Experimental Research Opportunities

    Science.gov (United States)

    Brusco, Michael J.

    2007-01-01

    The study of human performance on discrete optimization problems has a considerable history that spans various disciplines. The two most widely studied problems are the Euclidean traveling salesperson problem and the quadratic assignment problem. The purpose of this paper is to outline a program of study for the measurement of human performance on…

  5. Biorefinery and Hydrogen Fuel Cell Research

    Energy Technology Data Exchange (ETDEWEB)

    K.C. Das; Thomas T. Adams; Mark A. Eiteman; John Stickney; Joy Doran Peterson; James R. Kastner; Sudhagar Mani; Ryan Adolphson

    2012-06-12

    In this project we focused on several aspects of technology development that advances the formation of an integrated biorefinery. These focus areas include: [1] establishment of pyrolysis processing systems and characterization of the product oils for fuel applications, including engine testing of a preferred product and its pro forma economic analysis; [2] extraction of sugars through a novel hotwater extaction process, and the development of levoglucosan (a pyrolysis BioOil intermediate); [3] identification and testing of the use of biochar, the coproduct from pyrolysis, for soil applications; [4] developments in methods of atomic layer epitaxy (for efficient development of coatings as in fuel cells); [5] advancement in fermentation of lignocellulosics, [6] development of algal biomass as a potential substrate for the biorefinery, and [7] development of catalysts from coproducts. These advancements are intended to provide a diverse set of product choices within the biorefinery, thus improving the cost effectiveness of the system. Technical effectiveness was demonstrated in the pyrolysis biooil based diesel fuel supplement, sugar extraction from lignocelluose, use of biochar, production of algal biomass in wastewaters, and the development of catalysts. Economic feasibility of algal biomass production systems seems attractive, relative to the other options. However, further optimization in all paths, and testing/demonstration at larger scales are required to fully understand the economic viabilities. The various coproducts provide a clear picture that multiple streams of value can be generated within an integrated biorefinery, and these include fuels and products.

  6. Causes of Indoor Air Quality Problems in Schools: Summary of Scientific Research

    Energy Technology Data Exchange (ETDEWEB)

    Bayer, C.W.

    2001-02-22

    chemical sensitivity versus bioaerosols (aerosolized microbes), or the contribution of the microorganisms to the chemical sensitivities, is not yet understood. If the inhabitants of a building exhibit similar symptoms of a clearly defined disease with a nature and time of onset that can be related to building occupancy, the disease is generally referred to as ''building-related illness.'' Once the SBS has been allowed to elevate to this level, buildings are typically evacuated and the costs associated with disruption of the building occupants, identification of the source of the problem, and eventual remediation can be significant. Understanding the primary causes of IAQ problems and how controllable factors--proper HVAC system design, allocation of adequate outdoor air, proper filtration, effective humidity control, and routine maintenance--can avert the problems may help all building owners, operators, and occupants to be more productive (Arens and Baughman 1996). This paper provides a comprehensive summary of IAQ research that has been conducted in various types of facilities. However, it focuses primarily on school facilities because, for numerous reasons that will become evident, they are far more susceptible to developing IAQ problems than most other types of facilities; and the occupants, children, are more significantly affected than adults (EPA 1998).

  7. Utilizing a logic model to identify clinical research problems: a lesson from philosophy of science

    Directory of Open Access Journals (Sweden)

    Collins CR

    2016-10-01

    Full Text Available Cynthia R Collins School of Nursing, College of Social Sciences, Loyola University, New Orleans, LA, USA Abstract: Communication and decision making in the health care workplace often involve finding solutions to ill-structured problems in uncertain, dynamic environments influenced by the competing interests of multiple stakeholders. In this environment, doctoral-prepared nurses who practice as administrators, policy makers, or advanced practice practitioners are often compelled to make important decisions based upon evaluating the merit of colleagues’ proposals against some desired organizational or population outcome. Of equal importance is the nurse leader’s own capacity to construct a compelling argument or proposal that will drive the organization forward to meet the evolving needs for quality health care. Where do we learn the skills necessary to foster this kind of critical thinking in our professional communications? The author suggests that one teaching–learning approach can be found through the thoughtful application of the work of British philosopher Steven Toulmin. Toulmin defined a model for both the analysis and derivation of logical arguments or proposals that can be readily learned and applied for use in health care systems. This model posits that a substantive argument or claim can be evaluated based on the assumptions it presumes (warrants and the strength of the evidence base (backing. Several of the social science professions have adapted Toulmin’s model to generate analysis and creative solutions to complex or emergent problems. The author proposes that an application of this model be included in the pedagogy of doctoral level Philosophy of Science or Nursing Theory courses. The Toulmin process often provides the doctoral student or novice researcher with their first real learning experience in defining the scope and inherent challenges of framing a clinical issue to be the focus of their scholarly translational

  8. Stem cell research: paths to cancer therapies and regenerative medicine.

    Science.gov (United States)

    Weissman, Irving

    2005-09-21

    Most tissues in complex metazoans contain a rare subset of cells that, at the single-cell level, can self-renew and also give rise to mature daughter cells. Such stem cells likely in development build tissues and are retained in adult life to regenerate them. Cancers and leukemias are apparently not an exception: rare leukemia stem cells and cancer stem cells have been isolated that contain all of the tumorigenicity of the whole tumor, and it is their properties that will guide future therapies. None of this was apparent just 20 years ago, yet this kind of stem cell thinking already provides new perspectives in medical science and could usher in new therapies. Today, political, religious, and ethical issues surround embryonic stem cell and patient-specific pluripotent stem cell research and are center stage in the attempts by governments to ban these fields for discovery and potential therapies. These interventions require physicians and physician-scientists to determine for themselves whether patient welfare or personal ethics will dominate in their practices, and whether all aspects of stem cell research can be pursued in a safe and regulated fashion.

  9. Development of New Technologies for Stem Cell Research

    Directory of Open Access Journals (Sweden)

    Xibo Ma

    2012-01-01

    Full Text Available Since the 1960s, the stem cells have been extensively studied including embryonic stem cells, neural stem cells, bone marrow hematopoietic stem cells, and mesenchymal stem cells. In the recent years, several stem cells have been initially used in the treatment of diseases, such as in bone marrow transplant. At the same time, isolation and culture experimental technologies for stem cell research have been widely developed in recent years. In addition, molecular imaging technologies including optical molecular imaging, positron emission tomography, single-photon emission computed tomography, and computed tomography have been developed rapidly in recent the 10 years and have also been used in the research on disease mechanism and evaluation of treatment of disease related with stem cells. This paper will focus on recent typical isolation, culture, and observation techniques of stem cells followed by a concise introduction. Finally, the current challenges and the future applications of the new technologies in stem cells are given according to the understanding of the authors, and the paper is then concluded.

  10. Some applications of nanotechnologies in stem cells research

    Energy Technology Data Exchange (ETDEWEB)

    Belicchi, M. [Fondazione IRCCS Ospedale Policlinico di Milano, Via Francesco Sforza, Milano 20122 (Italy); Cancedda, R. [Istituto Nazionale per la Ricerca sul Cancro and Dipartimento di Oncologia Biologia e Genetica - Universita di Genova, Largo R. Benzi 10, Genova 16132 (Italy); Cedola, A. [Istituto di Fotonica e Nanotecnologie - CNR, Via Cinto Romano 42, Roma 00156 (Italy); Fiori, F. [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); INBB - Istituto Nazionale Biostrutture e Biosistemi (Italy); CNISM - Matec (Ancona) (Italy); Gavina, M. [Fondazione IRCCS Ospedale Policlinico di Milano, Via Francesco Sforza, Milano 20122 (Italy); Giuliani, A. [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); CNISM - Matec (Ancona) (Italy); Komlev, V.S. [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); Institute for Physical Chemistry of Ceramics, Russian Academy of Sciences, Ozernaya 48, 119361 Moscow (Russian Federation); Lagomarsino, S. [Istituto di Fotonica e Nanotecnologie - CNR, Via Cinto Romano 42, Roma 00156 (Italy); Mastrogiacomo, M. [Istituto Nazionale per la Ricerca sul Cancro and Dipartimento di Oncologia Biologia e Genetica - Universita di Genova, Largo R. Benzi 10, Genova 16132 (Italy); Renghini, C. [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); INBB - Istituto Nazionale Biostrutture e Biosistemi (Italy); CNISM - Matec (Ancona) (Italy); Rustichelli, F., E-mail: f.rustichelli@univpm.i [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); INBB - Istituto Nazionale Biostrutture e Biosistemi (Italy); CNISM - Matec (Ancona) (Italy)

    2009-12-15

    Stem cell based tissue engineering therapies involve the administration of ex vivo manipulated stem cell populations with the purpose of repairing and regenerating damaged or diseased tissue. Currently available methods of monitoring transplanted cells are quite limited. To monitor the outcomes of stem cell therapy longitudinally requires the development of non-destructive strategies that are capable of identifying the location, magnitude, and duration of cellular survival and fate. The recent development of imaging techniques offers great potential to address these critical issues by non-invasively tracking the fate of the transplanted cells. This review offers a focused presentation of some examples of the use of imaging techniques connected to the nanotechnological world in research areas related to stem cells. In particular investigations will be considered concerning tissue-engineered bone, treatment of intervertebral disc degeneration, treatment by human stem cells of muscular dystrophy of Duchenne in small animal models and the repair of spinal cord injuries.

  11. A research agenda for helminth diseases of humans: the problem of helminthiases.

    Directory of Open Access Journals (Sweden)

    Sara Lustigman

    Full Text Available A disproportionate burden of helminthiases in human populations occurs in marginalised, low-income, and resource-constrained regions of the world, with over 1 billion people in developing areas of sub-Saharan Africa, Asia, and the Americas infected with one or more helminth species. The morbidity caused by such infections imposes a substantial burden of disease, contributing to a vicious circle of infection, poverty, decreased productivity, and inadequate socioeconomic development. Furthermore, helminth infection accentuates the morbidity of malaria and HIV/AIDS, and impairs vaccine efficacy. Polyparasitism is the norm in these populations, and infections tend to be persistent. Hence, there is a great need to reduce morbidity caused by helminth infections. However, major deficiencies exist in diagnostics and interventions, including vector control, drugs, and vaccines. Overcoming these deficiencies is hampered by major gaps in knowledge of helminth biology and transmission dynamics, platforms from which to help develop such tools. The Disease Reference Group on Helminths Infections (DRG4, established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR, was given the mandate to review helminthiases research and identify research priorities and gaps. In this review, we provide an overview of the forces driving the persistence of helminthiases as a public health problem despite the many control initiatives that have been put in place; identify the main obstacles that impede progress towards their control and elimination; and discuss recent advances, opportunities, and challenges for the understanding of the biology, epidemiology, and control of these infections. The helminth infections that will be discussed include: onchocerciasis, lymphatic filariasis, soil-transmitted helminthiases, schistosomiasis, food-borne trematodiases, and taeniasis/cysticercosis.

  12. Assessment of Research Needs for Advanced Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Penner, S.S.

    1985-11-01

    The DOE Advanced Fuel Cell Working Group (AFCWG) was formed and asked to perform a scientific evaluation of the current status of fuel cells, with emphasis on identification of long-range research that may have a significant impact on the practical utilization of fuel cells in a variety of applications. The AFCWG held six meetings at locations throughout the country where fuel cell research and development are in progress, for presentations by experts on the status of fuel cell research and development efforts, as well as for inputs on research needs. Subsequent discussions by the AFCWG have resulted in the identification of priority research areas that should be explored over the long term in order to advance the design and performance of fuel cells of all types. Surveys describing the salient features of individual fuel cell types are presented in Chapters 2 to 6 and include elaborations of long-term research needs relating to the expeditious introduction of improved fuel cells. The Introduction and the Summary (Chapter 1) were prepared by AFCWG. They were repeatedly revised in response to comments and criticism. The present version represents the closest approach to a consensus that we were able to reach, which should not be interpreted to mean that each member of AFCWG endorses every statement and every unexpressed deletion. The Introduction and Summary always represent a majority view and, occasionally, a unanimous judgment. Chapters 2 to 6 provide background information and carry the names of identified authors. The identified authors of Chapters 2 to 6, rather than AFCWG as a whole, bear full responsibility for the scientific and technical contents of these chapters.

  13. The effects of child- and youth-coaching for children in multi-problem families : Research proposal

    NARCIS (Netherlands)

    van Assen, Arjen; Grietens, Hans; Post, Wendy; Knot-Dickscheit, Jana

    2015-01-01

    This research proposal was presented at the ISED research days 2015 at Leiden University. Children and teenagers growing up in environments with multiple stressors are at an increased risk for developing behavioural and emotional problems. In this proposal a study is presented that aims to evaluate

  14. One More Time: The Need for More Mathematical Problem Solving and What the Research Says about It

    Science.gov (United States)

    Woodward, John

    2013-01-01

    This article reviews recent research in math problem solving for students with learning disabilities. Two recently published syntheses of research on mathematics by the Institute of Education Sciences (IES) are used as frameworks for interpreting this body of work. A significant amount of the work in special education over the last decade is…

  15. Identifying Opportunities for Collaborations in International Engineering Education Research on Problem-and Project-Based Learning

    Science.gov (United States)

    Beddoes, Kacey D.; Jesiek, Brent K.; Borrego, Maura

    2010-01-01

    We report on the results of a study to examine the global state of engineering education research on problem-and project-based learning (PBL). This paper has two major aims. First, we analyze a large collection of conference papers and journal articles to report on research trends in PBL, including in specific, leading countries. Second, based…

  16. Virtual manufacturing cells : A taxonomy of past research and identification of future research issues

    NARCIS (Netherlands)

    Nomden, G.; Slomp, J.; Suresh, N.

    This paper reviews prior research in the area of virtual manufacturing cells. A virtual manufacturing cell (VMC) is a group of resources that is dedicated to the manufacturing of a part family, though this grouping is not reflected in the physical structure of the manufacturing system.

  17. Virtual manufacturing cells : A taxonomy of past research and identification of future research issues

    NARCIS (Netherlands)

    Nomden, G; Slomp, J; Suresh, NC

    2005-01-01

    This paper reviews prior research in the area of virtual manufacturing cells. A virtual manufacturing cell (VMC) is a group of resources that is dedicated to the manufacturing of a part family, though this grouping is not reflected in the physical structure of the manufacturing system. Distinguishin

  18. A Bibliometric Analysis of Publications on Pluripotent Stem Cell Research

    Directory of Open Access Journals (Sweden)

    Changshuan L. Lin

    2015-04-01

    Full Text Available Objective: Human pluripotent stem cells are self-renewing cells with the ability to differentiate into a variety of cells and are viewed to have great potential in the field of regenerative medicine. Research in pluripotent stem cells holds great promise for patient specific therapy in various diseases. In this study, pluripotent stem cell articles published from 1991 to 2012 were screened and retrieved from Science Citation Index Expanded (SCI-EXPANDED. Materials and Methods: In this retrospective study, the publication trend, citation trends for top articles, distributions of journals and Web of Science categories were analyzed. Five bibliometric indicators including total articles, independent articles, collaborative articles, first author articles, and corresponding author articles were applied to compare publications between countries and institutions. Results: The impact of top articles changed from year to year. Top cited articles in previous publication years were not the same as recent years. "Induced pluripotent stem cell (s" and "embryonic stem cell (s" were the most used author keywords in pluripotent stem cell research. In addition, the winner of the Nobel Prize in physiology or medicine in 2012, Prof. Shinya Yamanaka, published four of the top ten most frequently cited articles. Conclusion: The comprehensive analysis of highly cited articles in the stem cell field could identify milestones and important contributors, giving a historic perspective on scientific progress.

  19. Nuclear Methods for Transmutation of Nuclear Waste: Problems, Perspextives, Cooperative Research - Proceedings of the International Workshop

    Science.gov (United States)

    Khankhasayev, Zhanat B.; Kurmanov, Hans; Plendl, Mikhail Kh.

    1996-12-01

    The Table of Contents for the full book PDF is as follows: * Preface * I. Review of Current Status of Nuclear Transmutation Projects * Accelerator-Driven Systems — Survey of the Research Programs in the World * The Los Alamos Accelerator-Driven Transmutation of Nuclear Waste Concept * Nuclear Waste Transmutation Program in the Czech Republic * Tentative Results of the ISTC Supported Study of the ADTT Plutonium Disposition * Recent Neutron Physics Investigations for the Back End of the Nuclear Fuel Cycle * Optimisation of Accelerator Systems for Transmutation of Nuclear Waste * Proton Linac of the Moscow Meson Factory for the ADTT Experiments * II. Computer Modeling of Nuclear Waste Transmutation Methods and Systems * Transmutation of Minor Actinides in Different Nuclear Facilities * Monte Carlo Modeling of Electro-nuclear Processes with Nonlinear Effects * Simulation of Hybrid Systems with a GEANT Based Program * Computer Study of 90Sr and 137Cs Transmutation by Proton Beam * Methods and Computer Codes for Burn-Up and Fast Transients Calculations in Subcritical Systems with External Sources * New Model of Calculation of Fission Product Yields for the ADTT Problem * Monte Carlo Simulation of Accelerator-Reactor Systems * III. Data Basis for Transmutation of Actinides and Fission Products * Nuclear Data in the Accelerator Driven Transmutation Problem * Nuclear Data to Study Radiation Damage, Activation, and Transmutation of Materials Irradiated by Particles of Intermediate and High Energies * Radium Institute Investigations on the Intermediate Energy Nuclear Data on Hybrid Nuclear Technologies * Nuclear Data Requirements in Intermediate Energy Range for Improvement of Calculations of ADTT Target Processes * IV. Experimental Studies and Projects * ADTT Experiments at the Los Alamos Neutron Science Center * Neutron Multiplicity Distributions for GeV Proton Induced Spallation Reactions on Thin and Thick Targets of Pb and U * Solid State Nuclear Track Detector and

  20. Solving a four-destination traveling salesman problem using Escherichia coli cells as biocomputers.

    Science.gov (United States)

    Esau, Michael; Rozema, Mark; Zhang, Tuo Huang; Zeng, Dawson; Chiu, Stephanie; Kwan, Rachel; Moorhouse, Cadence; Murray, Cameron; Tseng, Nien-Tsu; Ridgway, Doug; Sauvageau, Dominic; Ellison, Michael

    2014-12-19

    The Traveling Salesman Problem involves finding the shortest possible route visiting all destinations on a map only once before returning to the point of origin. The present study demonstrates a strategy for solving Traveling Salesman Problems using modified E. coli cells as processors for massively parallel computing. Sequential, combinatorial DNA assembly was used to generate routes, in the form of plasmids made up of marker genes, each representing a path between destinations, and short connecting linkers, each representing a given destination. Upon growth of the population of modified E. coli, phenotypic selection was used to eliminate invalid routes, and statistical analysis was performed to successfully identify the optimal solution. The strategy was successfully employed to solve a four-destination test problem.

  1. Hematopoietic Stem Cell Transplantation in Adult Sickle Cell Disease: Problems and Solutions

    Directory of Open Access Journals (Sweden)

    Hakan Özdoğu

    2015-09-01

    Full Text Available Sickle cell disease-related organ injuries cannot be prevented despite hydroxyurea use, infection prophylaxis, and supportive therapies. As a consequence, disease-related mortality reaches 14% in adolescents and young adults. Hematopoietic stem cell transplantation is a unique curative therapeutic approach for sickle cell disease. Myeloablative allogeneic hematopoietic stem cell transplantation is curative for children with sickle cell disease. Current data indicate that long-term disease-free survival is about 90% and overall survival about 95% after transplantation. However, it is toxic in adults due to organ injuries. In addition, this curative treatment approach has several limitations, such as difficulties to find donors, transplant-related mortality, graft loss, graft-versus-host disease (GVHD, and infertility. Engraftment effectivity and toxicity for transplantations performed with nonmyeloablative reduced-intensity regimens in adults are being investigated in phase 1/2 trials at many centers. Preliminary data indicate that GVHD could be prevented with transplantations performed using reduced-intensity regimens. It is necessary to develop novel regimens to prevent graft loss and reduce the risk of GVHD.

  2. Prostate Cancer Stem-Like Cells | Center for Cancer Research

    Science.gov (United States)

    Prostate cancer is the third leading cause of cancer-related death among men, killing an estimated 27,000 men each year in the United States. Men with advanced prostate cancer often become resistant to conventional therapies. Many researchers speculate that the emergence of resistance is due to the presence of cancer stem cells, which are believed to be a small subpopulation of tumor cells that can self-renew and give rise to more differentiated tumor cells. It is thought that these stem cells survive initial therapies (such as chemotherapy and hormone therapy) and then generate new tumor cells that are resistant to these standard treatments. If prostate cancer stem cells could be identified and characterized, it might be possible to design treatments that prevent resistance.

  3. Unique cell culture systems for ground based research

    Science.gov (United States)

    Lewis, Marian L.

    1990-01-01

    The horizontally rotating fluid-filled, membrane oxygenated bioreactors developed at NASA Johnson for spacecraft applications provide a powerful tool for ground-based research. Three-dimensional aggregates formed by cells cultured on microcarrier beads are useful for study of cell-cell interactions and tissue development. By comparing electron micrographs of plant seedlings germinated during Shuttle flight 61-C and in an earth-based rotating bioreactor it is shown that some effects of microgravity are mimicked. Bioreactors used in the UAH Bioreactor Laboratory will make it possible to determine some of the effects of altered gravity at the cellular level. Bioreactors can be valuable for performing critical, preliminary-to-spaceflight experiments as well as medical investigations such as in vitro tumor cell growth and chemotherapeutic drug response; the enrichment of stem cells from bone marrow; and the effect of altered gravity on bone and muscle cell growth and function and immune response depression.

  4. New perspectives in human stem cell therapeutic research

    Directory of Open Access Journals (Sweden)

    Trounson Alan

    2009-06-01

    Full Text Available Abstract Human stem cells are in evaluation in clinical stem cell trials, primarily as autologous bone marrow studies, autologous and allogenic mesenchymal stem cell trials, and some allogenic neural stem cell transplantation projects. Safety and efficacy are being addressed for a number of disease state applications. There is considerable data supporting safety of bone marrow and mesenchymal stem cell transplants but the efficacy data are variable and of mixed benefit. Mechanisms of action of many of these cells are unknown and this raises the concern of unpredictable results in the future. Nevertheless there is considerable optimism that immune suppression and anti-inflammatory properties of mesenchymal stem cells will be of benefit for many conditions such as graft versus host disease, solid organ transplants and pulmonary fibrosis. Where bone marrow and mesenchymal stem cells are being studied for heart disease, stroke and other neurodegenerative disorders, again progress is mixed and mostly without significant benefit. However, correction of multiple sclerosis, at least in the short term is encouraging. Clinical trials on the use of embryonic stem cell derivatives for spinal injury and macular degeneration are beginning and a raft of other clinical trials can be expected soon, for example, the use of neural stem cells for killing inoperable glioma and embryonic stem cells for regenerating β islet cells for diabetes. The change in attitude to embryonic stem cell research with the incoming Obama administration heralds a new co-operative environment for study and evaluation of stem cell therapies. The Californian stem cell initiative (California Institute for Regenerative Medicine has engendered global collaboration for this new medicine that will now also be supported by the US Federal Government. The active participation of governments, academia, biotechnology, pharmaceutical companies, and private investment is a powerful consortium for

  5. A numerical method for the inverse problem of cell traction in 3D

    Science.gov (United States)

    Vitale, G.; Preziosi, L.; Ambrosi, D.

    2012-09-01

    Force traction microscopy is an inversion method that allows us to obtain the stress field applied by a living cell on the environment on the basis of a pointwise knowledge of the displacement produced by the cell itself. This classical biophysical problem, usually addressed in terms of Green’s functions, can be alternatively tackled in a variational framework. In such a case, a variation of the error functional under suitable regularization is operated in view of its minimization. This setting naturally suggests the introduction of a new equation, based on the adjoint operator of the elasticity problem. In this paper, we illustrate a numerical strategy of the inversion method that discretizes the partial differential equations associated with the optimal control problem by finite elements. A detailed discussion of the numerical approximation of a test problem (with known solution) that contains most of the mathematical difficulties of the real one allows a precise evaluation of the degree of confidence that one can achieve in the numerical results.

  6. RESEARCH ON PROBLEMS WITH PROJECTS AND PARTNERSHIPS THAT PUBLIC INSTITUTIONS IN THE CENTRE REGION FACED IN ACCESSING EUROPEAN FUNDS

    Directory of Open Access Journals (Sweden)

    DUMITRASCU DANUT

    2012-12-01

    Full Text Available European project management is the main filed of the article. Assuming a connection between the degree of absorption of European funds and the degree of maturity of the Romanian society in terms of project management, the article seeks to identify the negative factors on accessing and carrying out European projects. The identified problem is a low degree of absorption of European funds in Romania, and the main objective of the research is to identify the problems faced by the public institutions in the Centre Region in accessing European funds and also the causes that led to the low absorption of European funds. This article’s research is based on a preliminary analysis performed by the authors on the rate of accessing of European funds published in the article called “The current state of European funds absorption through funding programmes – measure of the Romanian performances in the project management practice”. The conclusion of this article was a low rate of absorption of European funds in Romania, a fact that reveals a poor practice of the theory on project management. This article identifies part of the causes of this situation by identifying a part of the problems that stood in the way of beneficiaries of European funds The qualitative and quantitative research methods are used in combination in the research. The investigation has however a highly quantitative character, the purpose of the qualitative research being to provide the prerequisites for achieving the quantitative research. The interview-based qualitative research enabled the researcher to get acquainted with the subjects’ problems related to the theme of investigation, the causes that have generated these problems. This preliminary investigation to the questionnaire-based research aims to provide information that would help the researcher prepare the questionnaire, so that the questions allow getting the most comprehensive information to

  7. Problems of scientific and development research concerning the reclamation of used foundry sands

    Directory of Open Access Journals (Sweden)

    R. Dańko

    2010-10-01

    Full Text Available In traditional technologies of casting moulds and core production on the basis of high-silica sands with binding agent addition, the reclamation consists mainly of a sand recovery and very seldom of a sand and bentonite recovery.Analysis of data from several countries indicates that from 600 to 1200 kg of fresh sand is used for 1 tonne of ferrous casting alloys. In Poland it is 1000 kg of sand for 1 tonne of castings [1]. Out of this amount approximately 20% of fresh sand is used for core production and the remaining amount for rebounding moulding sands. Analysis of data from 20 largest Polish foundries, performed in 2004 [2] indicates that approximately 50% of waste foundry sands is reclaimed while the rest is directed to dumping grounds. Taking into account all remaining foundries it can be estimated that approximately 250-350 000 tonnes of waste foundry sands are sent to dumping grounds annually.Important issue are costs of storage, which depend on the kind of wastes and on the ownership form of dump-sites (municipal dumpinggrounds, plant’s or own [belonging to the foundry] as well as on their relation to the costs of purchasing fresh sands. Average charges for storage of moulding sands wastes on storage yards in Europe are within the range: 12.5 to 61 Eu, which means from 85% to above 400% of purchasing costs of 1 tonne of fresh high-silica sand. The contractual price accepted for such sand in the BREF UE document [3] is 14.56 Eu. Problems of scientific and development research concerning the reclamation of used foundry sands can be systematised according to the research fields and the actual state of knowledge - based on the analysis of scientific papers.

  8. Gold deposits in metamorphic belts: Overview of current understanding, outstanding problems, future research, and exploration significance

    Science.gov (United States)

    Groves, D.I.; Goldfarb, R.J.; Robert, F.; Hart, C.J.R.

    2003-01-01

    Metamorphic belts are complex regions where accretion or collision has added to, or thickened, continental crust. Gold-rich deposits can be formed at all stages of orogen evolution, so that evolving metamorphic belts contain diverse gold deposit types that may be juxtaposed or overprint each other. This partly explains the high level of controversy on the origin of some deposit types, particularly those formed or overprinted/remobilized during the major compressional orogeny that shaped the final geometry of the hosting metamorphic belts. These include gold-dominated orogenic and intrusion-related deposits, but also particularly controversial gold deposits with atypical metal associations. There are a number of outstanding problems for all types of gold deposits in metamorphc belts. These include the following: (1) definitive classifications, (2) unequivocal recognition of fluid and metal sources, (3) understanding of fluid migration and focusing at all scales, (4) resolution of the precise role of granitoid magmatism, (5) precise gold-depositional mechanisms, particularly those producing high gold grades, and (6) understanding of the release of CO2-rich fluids from subducting slabs and subcreted oceanic crust and granitoid magmas at different crustal levels. Research needs to be better coordinated and more integrated, such that detailed fluid-inclusion, trace-element, and isotopic studies of both gold deposits and potential source rocks, using cutting-edge technology, are embedded in a firm geological framework at terrane to deposit scales. Ultimately, four-dimensional models need to be developed, involving high-quality, three-dimensional geological data combined with integrated chemical and fluid-flow modeling, to understand the total history of the hydrothermal systems involved. Such research, particularly that which can predict superior targets visible in data sets available to exploration companies before discovery, has obvious spin-offs for global- to deposit

  9. How GIS can help address the uncertain geographic context problem in social science research

    NARCIS (Netherlands)

    Kwan, M.P.

    2012-01-01

    The uncertain geographic context problem (UGCoP), first articulated by Kwan (2012; The uncertain geographic context problem. Annals of the Association of American Geographers, 102 (5), 958–968), refers to the problem that findings about the effects of area-based contextual variables on individual be

  10. Efficient Parallel Sorting for Migrating Birds Optimization When Solving Machine-Part Cell Formation Problems

    Directory of Open Access Journals (Sweden)

    Ricardo Soto

    2016-01-01

    Full Text Available The Machine-Part Cell Formation Problem (MPCFP is a NP-Hard optimization problem that consists in grouping machines and parts in a set of cells, so that each cell can operate independently and the intercell movements are minimized. This problem has largely been tackled in the literature by using different techniques ranging from classic methods such as linear programming to more modern nature-inspired metaheuristics. In this paper, we present an efficient parallel version of the Migrating Birds Optimization metaheuristic for solving the MPCFP. Migrating Birds Optimization is a population metaheuristic based on the V-Flight formation of the migrating birds, which is proven to be an effective formation in energy saving. This approach is enhanced by the smart incorporation of parallel procedures that notably improve performance of the several sorting processes performed by the metaheuristic. We perform computational experiments on 1080 benchmarks resulting from the combination of 90 well-known MPCFP instances with 12 sorting configurations with and without threads. We illustrate promising results where the proposal is able to reach the global optimum in all instances, while the solving time with respect to a nonparallel approach is notably reduced.

  11. [D-cells of the gastroenteropancreatic system: development, structure, function and regeneration (history and current state of the problem)].

    Science.gov (United States)

    Ivanova, V F; Kostiukevich, S V

    2015-01-01

    The present review summarizes the literature data and the results of authors' own research on the development, structure, function and regeneration of D-endocrinocytes of gastroenteropancreatic (GEP) system. The history of the research of these cells is reviewed and its current state of the problem is discussed. The information on the difference of somatostatin-producing D-endocrinocytes from other types of endocrine cells of GAP system is presented, namely, the prevalence of these cells in all the organs of the digestive system (stomach, small and large intestine, pancreas) and other systems of the body, the peculiarities of their structure and regeneration in various species of vertebrate animals and humans in embryonic development, under conditions of normal functioning and in various types of pathology. On the basis of the data on the early differentiation of D-endocrinocytes and their secretion of hormones during embryonic development, structure, cytophysiology and relationships within the general endocrinocyte population, it is suggested that D-endocrinocytes play an important role in the morpho-functional state of GEP system.

  12. Thoughts and Practice on Some Problems about Research and Application of Two-Line Hybrid Rice

    Directory of Open Access Journals (Sweden)

    Li-yun CHEN

    2011-06-01

    Full Text Available The main problems about research and application of two-line hybrid rice were reviewed, including the confusing nomenclature and male sterile lines classification, the unclear characteristics of photoperiod and temperature responses and the unsuitable site selection for male sterile line and hybrid rice seed production. In order to efficiently and accurately use dual-purpose genic male sterile lines, four types, including PTGMS (photo-thermo-sensitive genic male sterile rice, TGMS (thermo-sensitive genic male sterile rice, reverse PTGMS and reverse TGMS, were proposed. A new idea for explaining the mechanism of sterility in dual-purpose hybrid rice was proposed. The transition from sterile to fertile was involved in the cooperative regulation of major-effect sterile genes and photoperiod and/or temperature sensitive ones. The minor-effect genes with accumulative effect on sterility were important factors that affected the critical temperature of sterility transfer. In order to make better use of dual-purpose lines, the characterization of responses to photoperiod and temperature of PTGMS should be made and the identification method for the characterization of photoperiod and temperature responses of PTGMS should also be put forward. The optimal ecological site for seed production could be determined according to the historical climate data and the requirements for the meteorological conditions during the different periods of seed production.

  13. Thoughts and Practice on Some Problems about Research and Application of Two-Line Hybrid Rice

    Institute of Scientific and Technical Information of China (English)

    CHEN Li-yun; LEI Dong-yang; TANG Wen-bang; XIAO Ying-hui

    2011-01-01

    The main problems about research and application of two-line hybrid rice were reviewed,including the confusing nomenclature and male sterile lines classification,the unclear characteristics of photoperiod and temperature responses and the unsuitable site selection for male sterile line and hybrid rice seed production.In order to efficiently and accurately use dual-purpose genic male sterile lines,four types,including PTGMS (photo-thermo-sensitive genic male sterile rice),TGMS (thermo-sensitive genic male sterile rice),reverse PTGMS and reverse TGMS,were proposed.A new idea for explaining the mechanism of sterility in dual-purpose hybrid rice was proposed.The transition from sterile to fertile was involved in the cooperative regulation of major-effect sterile genes and photoperiod and/or temperature sensitive ones.The minor-effect genes with accumulative effect on sterility were important factors that affected the critical temperature of sterility transfer.In order to make better use of dual-purpose lines,the charecterization of responses to photoperiod and temperature of PTGMS should be made and the identification method for the characterization of photoperiod and temperature responses of PTGMS should also be put forward.The optimal ecological site for seed production could be determined according to the historical climate data and the requirements for the meteorological conditions during the different periods of seed production.

  14. Transforming ocular surface stem cell research into successful clinical practice

    Directory of Open Access Journals (Sweden)

    Virender S Sangwan

    2014-01-01

    Full Text Available It has only been a quarter of a century since the discovery of adult stem cells at the human corneo-scleral limbus. These limbal stem cells are responsible for generating a constant and unending supply of corneal epithelial cells throughout life, thus maintaining a stable and uniformly refractive corneal surface. Establishing this hitherto unknown association between ocular surface disease and limbal dysfunction helped usher in therapeutic approaches that successfully addressed blinding conditions such as ocular burns, which were previously considered incurable. Subsequent advances in ocular surface biology through basic science research have translated into innovations that have made the surgical technique of limbal stem cell transplantation simpler and more predictable. This review recapitulates the basic biology of the limbus and the rationale and principles of limbal stem cell transplantation in ocular surface disease. An evidence-based algorithm is presented, which is tailored to clinical considerations such as laterality of affliction, severity of limbal damage and concurrent need for other procedures. Additionally, novel findings in the form of factors influencing the survival and function of limbal stem cells after transplantation and the possibility of substituting limbal cells with epithelial stem cells of other lineages is also discussed. Finally this review focuses on the future directions in which both basic science and clinical research in this field is headed.

  15. Polymer electrolyte fuel cell stack research and development

    Energy Technology Data Exchange (ETDEWEB)

    Squadrito, G.; Barbera, O.; Giacoppo, G.; Urbani, F.; Passalacqua, E. [Istituto di Tecnologie Avanzate per l' Energia ' ' Nicola Giordano' ' del CNR (CNR, ITAE), via Salita per, Santa Lucia sopra Contesse 5, Messina (Italy)

    2008-04-15

    The research activity in polymer electrolyte fuel cell (PEFC) is oriented to the evolution of components and devices for the temperature range from 20 to 130{sup o}C, and covers all the aspects of this matter: membranes and electrodes, fuel cell stack engineering (design and manufacturing) and characterization, computational modelling and small demonstration systems prototyping. Particular attention is devoted to portable and automotive application. Membranes research is focused on thermostable polymers (polyetheretherketone, polysulphone, etc.) and composite membranes able to operate at higher temperature (>100{sup o}C) and lower humidification than the commercial Nafion {sup registered}, while Pt load reduction and gas diffusion layer improvement are the main goals for the electrode development. PEFC stack engineering and characterization activity involve different aspects such as the investigation of new materials for stack components, fuel cell modelling and performance optimization by computational techniques, single cell and stack electrochemical characterization, development of investigation tools for stack monitoring and data acquisition. A lot of work has been focused to the fuel cell stack architecture, assembling, gas leakage and cross-over reduction (gasketing), flow field and manifold design. Computational fluid dynamics studies have been performed to investigate and improve reactants distribution inside the cell. A flow field design methodology, developed in this framework and related to serpentine like flow field, is actually under investigation. All of these aspects of PEFC stack research are realized in the framework of National and European research projects, or in collaboration with industries and other research centres. In the present work our stack research activity is reported and the most important results are also considered. (author)

  16. Integrative genome-wide approaches in embryonic stem cell research.

    Science.gov (United States)

    Zhang, Xinyue; Huang, Jing

    2010-10-01

    Embryonic stem (ES) cells are derived from blastocysts. They can differentiate into the three embryonic germ layers and essentially any type of somatic cells. They therefore hold great potential in tissue regeneration therapy. The ethical issues associated with the use of human embryonic stem cells are resolved by the technical break-through of generating induced pluripotent stem (iPS) cells from various types of somatic cells. However, how ES and iPS cells self-renew and maintain their pluripotency is still largely unknown in spite of the great progress that has been made in the last two decades. Integrative genome-wide approaches, such as the gene expression microarray, chromatin immunoprecipitation based microarray (ChIP-chip) and chromatin immunoprecipitation followed by massive parallel sequencing (ChIP-seq) offer unprecedented opportunities to elucidate the mechanism of the pluripotency, reprogramming and DNA damage response of ES and iPS cells. This frontier article summarizes the fundamental biological questions about ES and iPS cells and reviews the recent advances in ES and iPS cell research using genome-wide technologies. To this end, we offer our perspectives on the future of genome-wide studies on stem cells.

  17. Research progress on the red cell diseases in China

    Institute of Scientific and Technical Information of China (English)

    YUE Lan-zhu; SHAO Zong-hong

    2012-01-01

    In recent years,there have been lots of progresses in the studies on red cell diseases in China,especially bone marrow failure diseases including immune-related pancytopenia,aplastic anemia,myelodysplastic syndrome,and paroxymal nocturnal hemoglobinuria.Numerous laboratory experiments as well as clinical researches have been carried out by Chinese hematologists,which brought about much clearer pathogenesis,more rational diagnosis methods and more effective therapies for red cell diseases.

  18. Research on the Problem of Workstation Copy in the Process of Mixed Production Line Reconstruction to Japanese Cell Production%面向JCP的混流生产线重构过程中的工位复制问题研究

    Institute of Scientific and Technical Information of China (English)

    夏春燕; 樊树海; 王进; 王宇乾

    2012-01-01

    介绍了日本式单元生产方式,并与混流生产方式进行了比较,日本式单元生产是将一条长的生产线分拆成多条短的生产线,使其既能适应多样的市场需求,又具有较高的生产效率.讨论了两者如何转化.重点研究了混流生产方式重构成日本式单元生产方式(JCP)过程中的工位复制问题.总结了解决该问题的一般步骤.首先,对产品进行分类,每一个生产单元生产一类产品.然后,通过物流费用与工位复制费用的比较,判断出需要复制的工位,最后,计算不复制工位情况下的总费用和复制工位情况下的总费用.%The Japanese cell production (JCP)is introduced,and is compared it mixed productionA long production line is divided into several short, lines in JCP,which can not only satisfy various market demands, but also has a high productivity.A nd how to translate from one to another is studied.A problem about how the mixed production could be changed into the Japanese cell production (JCP)is discussed.First,the products were clustered,and each cluster of products was produced by a production cell.Then through comparing logistic cost with the cost of workstation copy, it could be determined which workstation needs to be copied. At last,the cost was calculated under the condition that the workstations were copied.

  19. Modifying a Research-Based Problem-Solving Intervention to Improve the Problem-Solving Performance of Fifth and Sixth Graders With and Without Learning Disabilities.

    Science.gov (United States)

    Krawec, Jennifer; Huang, Jia

    2016-05-10

    The purpose of the present study was to test the efficacy of a modified cognitive strategy instructional intervention originally developed to improve the mathematical problem solving of middle and high school students with learning disabilities (LD). Fifth and sixth grade general education mathematics teachers and their students of varying ability (i.e., average-achieving [AA] students, low-achieving [LA] students, and students with LD) participated in the research study. Several features of the intervention were modified, including (a) explicitness of instruction, (b) emphasis on meta-cognition, (c) focus on problem-solving prerequisites, (d) extended duration of initial intervention, and (e) addition of visual supports. General education math teachers taught all instructional sessions to their inclusive classrooms. Curriculum-based measures (CBMs) of math problem solving were administered five times over the course of the year. A multilevel model (repeated measures nested within students and students nested within schools) was used to analyze student progress on CBMs. Though CBM scores in the intervention group were initially lower than that of the comparison group, intervention students improved significantly more in the first phase, with no differences in the second phase. Implications for instruction are discussed as well as directions for future research.

  20. Adult human brain cell culture for neuroscience research.

    Science.gov (United States)

    Gibbons, Hannah M; Dragunow, Mike

    2010-06-01

    Studies of the brain have progressed enormously through the use of in vivo and in vitro non-human models. However, it is unlikely such studies alone will unravel the complexities of the human brain and so far no neuroprotective treatment developed in animals has worked in humans. In this review we discuss the use of adult human brain cell culture methods in brain research to unravel the biology of the normal and diseased human brain. The advantages of using adult human brain cells as tools to study human brain function from both historical and future perspectives are discussed. In particular, studies using dissociated cultures of adult human microglia, astrocytes, oligodendrocytes and neurons are described and the applications of these types of study are evaluated. Alternative sources of human brain cells such as adult neural stem cells, induced pluripotent stem cells and slice cultures of adult human brain tissue are also reviewed. These adult human brain cell culture methods could benefit basic research and more importantly, facilitate the translation of basic neuroscience research to the clinic for the treatment of brain disorders. Copyright 2009 Elsevier Ltd. All rights reserved.

  1. In focus: molecular and cell biology research in China.

    Science.gov (United States)

    Yao, Xuebiao; Li, Dangsheng; Pei, Gang

    2013-09-01

    An interactive, intellectual environment with good funding opportunities is essential for the development and success of basic research. The fast-growing economy and investment in science, together with a visionary plan, have attracted foreign scholars to work in China, motivated world-class Chinese scientists to return and strengthened the country's international collaborations. As a result, molecular and cell biology research in China has evolved rapidly over the past decade.

  2. Quantitative and qualitative approaches in educational researchproblems and examples of controlled understanding through interpretive methods

    Science.gov (United States)

    Neumann, Karl

    1987-06-01

    In the methodological discussion of recent years it has become apparent that many research problems, including problems relating to the theory of educational science, cannot be solved by using quantitative methods. The multifaceted aspects of human behaviour and all its environment-bound subtle nuances, especially the process of education or the development of identity, cannot fully be taken into account within a rigid neopositivist approach. In employing the paradigm of symbolic interactionism as a suitable model for the analysis of processes of education and formation, the research has generally to start out from complex reciprocal social interactions instead of unambigious connections of causes. In analysing several particular methodological problems, the article demonstrates some weaknesses of quantitative approaches and then shows the advantages in and the necessity for using qualitative research tools.

  3. The future of human embryonic stem cell research: addressing ethical conflict with responsible scientific research.

    Science.gov (United States)

    Gilbert, David M

    2004-05-01

    Embryonic stem (ES) cells have almost unlimited regenerative capacity and can potentially generate any body tissue. Hence they hold great promise for the cure of degenerative human diseases. But their derivation and the potential for misuse have raised a number of ethical issues. These ethical issues threaten to paralyze pubic funding for ES cell research, leaving experimentation in the hands of the private sector and precluding the public's ability to monitor practices, research alternatives, and effectively address the very ethical issues that are cause for concern in the first place. With new technology being inevitable, and the potential for abuse high, government must stay involved if the public is to play a role in shaping the direction of research. In this essay, I will define levels of ethical conflict that can be delineated by the anticipated advances in technology. From the urgent need to derive new ES cell lines with existing technology, to the most far-reaching goal of deriving genetically identical tissues from an adult patients cells, technology-specific ethical dilemmas can be defined and addressed. This staged approach provides a solid ethical framework for moving forward with ES cell research. Moreover, by anticipating the moral conflicts to come, one can predict the types of scientific advances that could overcome these conflicts, and appropriately direct federal funding toward these goals to offset potentially less responsible research directives that will inevitably go forward via private or foreign funding.

  4. Proteomics research on muscle-invasive bladder transitional cell carcinoma

    Directory of Open Access Journals (Sweden)

    Cao Yan

    2011-06-01

    Full Text Available Abstract Background Aimed to facilitate candidate biomarkers selection and improve network-based multi-target therapy, we perform comparative proteomics research on muscle-invasive bladder transitional cell carcinoma. Laser capture microdissection was used to harvest purified muscle-invasive bladder cancer cells and normal urothelial cells from 4 paired samples. Two-dimensional liquid chromatography tandem mass spectrometry was used to identify the proteome expression profile. The differential proteins were further analyzed using bioinformatics tools and compared with the published literature. Results A total of 885/890 proteins commonly appeared in 4 paired samples. 295/337 of the 488/493 proteins that specific expressed in tumor/normal cells own gene ontology (GO cellular component annotation. Compared with the entire list of the international protein index (IPI, there are 42/45 GO terms exhibited as enriched and 9/5 exhibited as depleted, respectively. Several pathways exhibit significantly changes between cancer and normal cells, mainly including spliceosome, endocytosis, oxidative phosphorylation, etc. Finally, descriptive statistics show that the PI Distribution of candidate biomarkers have certain regularity. Conclusions The present study identified the proteome expression profile of muscle-invasive bladder cancer cells and normal urothelial cells, providing information for subcellular pattern research of cancer and offer candidate proteins for biomarker panel and network-based multi-target therapy.

  5. Stem cell therapy for joint problems using the horse as a clinically relevant animal model

    DEFF Research Database (Denmark)

    Koch, Thomas Gadegaard; Betts, Dean H.

    2007-01-01

    of the developmental biology of synovial joints and their pathologies. Before human clinical trials are undertaken, stem cell-based therapies for non-life-threatening disorders should be evaluated for their safety and efficacy using animal models of spontaneous disease and not solely by the existing laboratory models...... of experimentally induced lesions. The horse lends itself as a good animal model of spontaneous joint disorders that are clinically relevant to similar human disorders. Equine stem cell and tissue engineering studies may be financially feasible to principal investigators and small biotechnology companies......Research into articular cartilage is a surprisingly recent endeavour and much remains to be learned about the normal development of the synovial joint and its components that interplay in osteoarthritis and focal cartilage defects. Stem cell research is likely to contribute to the understanding...

  6. Proceedings of REMR Workshop on Research Priorities for Drainage System and Relief Well Problems. Repair, Evaluation, Maintenance, and Rehabilitation Research Program

    Science.gov (United States)

    1989-07-01

    assimilate inorganic carbon for cell growth and development. Later research by Molisch in 1892 and 1910, however, showed that some iron bacteria grew well...heterotrophically; therefore, they used organic carbon for an energy source and cell development. As a result of the research of Molisch , it is the...deposition of iron by these bacteria. Molisch , in a series of studies from 1892 through 1910, was able to grow cultures of iron bacteria on organic medium

  7. The stem cell and tissue engineering research in Chinese ophthalmology

    Institute of Scientific and Technical Information of China (English)

    GE Jian; LIU Jingbo

    2007-01-01

    Much has been considerably developed recently in the ophthalmic research of stem cell (SC) and tissue engineering (TE).They have become closer to the clinical practice,standardized and observable.Leading edge research of SC and TE on the ocular surface reconstruction,neuroregeneration and protection,and natural animal model has become increasingly available.However,challenges remain on the way,especially on the aspects of function reconstruction and specific differentiation.This paper reviews the new developments in this area with an intention of identifying research priorities for the future.

  8. [In vitro cell culture technology in cosmetology research].

    Science.gov (United States)

    Gojniczek, Katarzyna; Garncarczyk, Agnieszka; Pytel, Agata

    2005-01-01

    For ages the humanity has been looking for all kind of active substances, which could be used in improving the health and the appearance of our skin. People try to find out how to protect the skin from harmful, environmental factors. Every year a lot of new natural and synthetic, chemical substances are discovered. All of them potentially could be used as a cosmetic ingredient. In cosmetology research most of new xenobiotics were tested in vivo on animals. Alternative methods to in vivo tests are in vitro tests with skin cell culture system. The aim of this work was to describe two-dimensional and tree-dimensional skin cell cultures. Additionally, in this work we wanted to prove the usefulness of in vitro skin cell cultures in cosmetology research.

  9. Physical Chemistry Research Toward Proton Exchange Membrane Fuel Cell Advancement.

    Science.gov (United States)

    Swider-Lyons, Karen E; Campbell, Stephen A

    2013-02-07

    Hydrogen fuel cells, the most common type of which are proton exchange membrane fuel cells (PEMFCs), are on a rapid path to commercialization. We credit physical chemistry research in oxygen reduction electrocatalysis and theory with significant breakthroughs, enabling more cost-effective fuel cells. However, most of the physical chemistry has been restricted to studies of platinum and related alloys. More work is needed to better understand electrocatalysts generally in terms of properties and characterization. While the advent of such highly active catalysts will enable smaller, less expensive, and more powerful stacks, they will require better understanding and a complete restructuring of the diffusion media in PEMFCs to facilitate faster transport of the reactants (O2) and products (H2O). Even Ohmic losses between materials become more important at high power. Such lessons from PEMFC research are relevant to other electrochemical conversion systems, including Li-air batteries and flow batteries.

  10. Organized ambivalence: when sickle cell disease and stem cell research converge.

    Science.gov (United States)

    Benjamin, Ruha

    2011-01-01

    This article analyzes sickle cell patient families' responses to stem cell transplant recruitment efforts. It identifies key dynamics that explain why sickle cell patient families are not undergoing stem cell transplants at the rate of other patient populations. It challenges the conventional focus on 'African-American distrust' as a set of attitudes grounded in collective memories of past abuses and projected on to current initiatives, by examining the sociality of distrust produced daily in the clinic and reinforced in broader politics of health investment. It draws upon a two-year multi-sited ethnography of a US-based stem cell research and cures initiative. Fieldwork included participant observation in a state stem cell agency, a publicly-funded stem cell transplant program, a sickle cell clinic, and semi-structured, open-ended interviews with caregivers and stem cell research stakeholders, all of which were subject to qualitative analysis. This paper finds ambivalence-in-action structured by three contextual strands: therapeutic uncertainties of the clinic, institutionalized conflation of healthcare and medical research, and political contests over scientific and medical investments. The paper posits that organized ambivalence is an analytic alternative to individualized notions of distrust and as a framework for implementing more participatory research initiatives that better account for the multiple uncertainties characteristic of regenerative medicine.

  11. Psychiatric Problems in Children and Adolescents with Sickle cell Disease, Based on Parent and Teacher Reports

    Directory of Open Access Journals (Sweden)

    Özalp Ekinci

    2012-09-01

    Full Text Available OBJECTIVE: This study aimed to investigate the occurrence of psychiatric problems in children and adolescents with sickle cell disease (SCD. METHODS: The Child Behavior Checklist for ages 4-18 years (CBCL/4-18, Conners’ Parent Rating Scale (CPRS, Conners’ Teacher Rating Scale (CTRS-R, and The Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale, clinician and parent forms (T-DSM-IV-S were given to the caregivers and teachers of 31 children with SCD aged between 7-18 years and the caregivers and teachers of 34 age matched controls with irondeficiency anemia. RESULTS: The SCD patients had higher scores on all 4 of scales. Among the subscales, internalizing problems, and attention problems were more prominent in the SCD patients. CONCLUSION: Children and adolescents with SCD appear to have an increased risk for psychiatric problems. Regular psychological evaluation and referral to child and adolescent psychiatry clinics may facilitate timely diagnosis and effective treatment of at-risk children and adolescents.

  12. Community Problem-Solving Framed as a Distributed Information Use Environment: Bridging Research and Practice

    Science.gov (United States)

    Durrance, Joan C.; Souden, Maria; Walker, Dana; Fisher, Karen E.

    2006-01-01

    Introduction: This article results from a qualitative study of 1) information behavior in community problem-solving framed as a distributed information use environment and 2) approaches used by a best-practice library to anticipate information needs associated with community problem solving. Method: Several approaches to data collection were…

  13. A Research on English Educational Problems among Intermediates in Middle School

    Institute of Scientific and Technical Information of China (English)

    兰凤英

    2015-01-01

    This paper mainly centers on the neglecting parts of English intermediates in middle school and presents their existing study problems. According to intermediates' characters and learning motivation, I will reveal reasons of these problems and come up with effective strategies from two aspects of English teachers and students.

  14. Research on ZnO/Si heterojunction solar cells

    Science.gov (United States)

    Chen, Li; Chen, Xinliang; Liu, Yiming; Zhao, Ying; Zhang, Xiaodan

    2017-06-01

    We put forward an n-ZnO/p-Si heterojunction solar cell model based on AFORS-HET simulations and provide experimental support in this article. ZnO:B (B-doped ZnO) thin films deposited by metal-organic chemical vapor deposition (MOCVD) are planned to act as electrical emitter layer on p-type c-Si substrate for photovoltaic applications. We investigate the effects of thickness, buffer layer, ZnO:B affinity and work function of electrodes on performances of solar cells through computer simulations using AFORS-HET software package. The energy conversion efficiency of the ZnO:B(n)/ZnO/c-Si(p) solar cell can achieve 17.16% ({V}{oc}: 675.8 mV, {J}{sc}: 30.24 mA/cm2, FF: 83.96%) via simulation. On a basis of optimized conditions in simulation, we carry out some experiments, which testify that the ZnO buffer layer of 20 nm contributes to improving performances of solar cells. The influences of growth temperature, thickness and diborane (B2H6) flow rates are also discussed. We achieve an appropriate condition for the fabrication of the solar cells using the MOCVD technique. The obtained conversion efficiency reaches 2.82% ({V}{oc}: 294.4 mV, {J}{sc}: 26.108 mA/cm2, FF: 36.66%). Project supported by the State Key Development Program for Basic Research of China (Nos. 2011CBA00706, 2011CBA00707), the Tianjin Applied Basic Research Project and Cutting-Edge Technology Research Plan (No. 13JCZDJC26900), the Tianjin Major Science and Technology Support Project (No. 11TXSYGX22100), the National High Technology Research and Development Program of China (No. 2013AA050302), and the Fundamental Research Funds for the Central Universities (No. 65010341).

  15. The A3 Problem Solving Report: A 10-Step Scientific Method to Execute Performance Improvements in an Academic Research Vivarium

    OpenAIRE

    Bassuk, James A.; Washington, Ida M.

    2013-01-01

    The purpose of this study was to illustrate the application of A3 Problem Solving Reports of the Toyota Production System to our research vivarium through the methodology of Continuous Performance Improvement, a lean approach to healthcare management at Seattle Children's (Hospital, Research Institute, Foundation). The Report format is described within the perspective of a 10-step scientific method designed to realize measurable improvements of Issues identified by the Report's Author, Sponso...

  16. Mature red blood cells: from optical model to inverse light-scattering problem.

    Science.gov (United States)

    Gilev, Konstantin V; Yurkin, Maxim A; Chernyshova, Ekaterina S; Strokotov, Dmitry I; Chernyshev, Andrei V; Maltsev, Valeri P

    2016-04-01

    We propose a method for characterization of mature red blood cells (RBCs) morphology, based on measurement of light-scattering patterns (LSPs) of individual RBCs with the scanning flow cytometer and on solution of the inverse light-scattering (ILS) problem for each LSP. We considered a RBC shape model, corresponding to the minimal bending energy of the membrane with isotropic elasticity, and constructed an analytical approximation, which allows rapid simulation of the shape, given the diameter and minimal and maximal thicknesses. The ILS problem was solved by the nearest-neighbor interpolation using a preliminary calculated database of 250,000 theoretical LSPs. For each RBC in blood sample we determined three abovementioned shape characteristics and refractive index, which also allows us to calculate volume, surface area, sphericity index, spontaneous curvature, hemoglobin concentration and content.

  17. [Mechanism research on the lupeol treatment on MCF-7 breast cancer cells based on cell metabonomics].

    Science.gov (United States)

    Shi, Dongdong; Kuang, Yuanyuan; Wang, Guiming; Peng, Zhangxiao; Wang, Yan; Yan, Chao

    2014-03-01

    The objective of this research is to investigate the suppressive effects of lupeol on MCF-7 breast cancer cells, and explore its mechanism on inhibiting the proliferation of MCF-7 cells based on cell metabonomics and cell cycle. Gas chromatography-mass spectrometry (GC-MS) was used in the cell metabonomics assay to identify metabolites of MCF-7 cells and MCF-7 cells treated with lupeol. Then, orthogonal partial least squares discriminant analysis (OPLS-DA) was used to process the metabolic data and model parameters of OPLS-DA were as follows: R2Ycum = 0.988, Q2Ycum = 0.964, which indicated that these two groups could be distinguished clearly. The metabolites (VIP (variable importance in the projection) > 1) were analyzed by t-test, and finally, metabolites (t < 0.05) were identified to be biomarkers. Eleven metabolites such as butanedioic acid, phosphoric acid, L-leucine and isoleucine which had a significant contribution to classification were selected and preliminarily identified due to the accurate mass. Cell cycle assay was analyzed by FACSCalibur. Since the cells in the phase of G1 were increased significantly after the treatment of lupeol, we speculated that lupeol has a blocking effect on the generation of succinyl-CoA and the reaction of substrate phosphorylation of tricarboxylic acid cycle of MCF-7 cells. This study provided a novel approach to the mechanism research on the lupeol treatment on MCF-7 breast cancer cells based on cell metabonomics.

  18. Against Lung Cancer Cells: To Be, or Not to Be, That Is the Problem

    Directory of Open Access Journals (Sweden)

    Naoko Okumura

    2012-01-01

    Full Text Available Tobacco smoke and radioactive radon gas impose a high risk for lung cancer. The radon-derived ionizing radiation and some components of cigarette smoke induce oxidative stress by generating reactive oxygen species (ROS. Respiratory lung cells are subject to the ROS that causes DNA breaks, which subsequently bring about DNA mutagenesis and are intimately linked with carcinogenesis. The damaged cells by oxidative stress are often destroyed through the active apoptotic pathway. However, the ROS also perform critical signaling functions in stress responses, cell survival, and cell proliferation. Some molecules enhance radiation-induced tumor cell killing via the reduction in DNA repair levels. Hence the DNA repair levels may be a novel therapeutic modality in overcoming drug resistance in lung cancer. Either survival or apoptosis, which is determined by the balance between DNA damage and DNA repair levels, may lender the major problems in cancer therapy. The purpose of this paper is to take a closer look at risk factor and at therapy modulation factor in lung cancer relevant to the ROS.

  19. An Improved Formulation of the Disclosure Auditing Problem for Secondary Cell Suppression

    Directory of Open Access Journals (Sweden)

    Jacco Daalmans

    2010-12-01

    Full Text Available Statistical agencies have to ensure that respondents' private information cannot be revealed from the tables they release. A well-known protection method is cell suppression, where values that provide too much information are left out from the table to be published. In a first step, sensitive cell values are suppressed. This is called primary suppression. In a second step, other values are suppressed as well to exclude that primarily suppressed values can be re-calculated from the values published in the table. This second step is called secondary cell suppression. In this article we explain that the problem of checking whether a pattern of secondary cell suppressions is safe for release or not is generally described in a slightly inconsistent way in the literature. We illustrate with examples that the criteria that are often applied to judge whether a table can be safely published or not do not always give satisfactory results. Furthermore, we present a new criterion and explore some of its consequences. The new criterion is an extension of the well-known (p,q-prior-posterior rule. This extension is for aggregations of suppressed cells for which a value can be derived from the table. Finally, we provide a method to apply the new criterion in practice.

  20. What's missing? Discussing stem cell translational research in educational information on stem cell "tourism".

    Science.gov (United States)

    Master, Zubin; Zarzeczny, Amy; Rachul, Christen; Caulfield, Timothy

    2013-01-01

    Stem cell tourism is a growing industry in which patients pursue unproven stem cell therapies for a wide variety of illnesses and conditions. It is a challenging market to regulate due to a number of factors including its international, online, direct-to-consumer approach. Calls to provide education and information to patients, their families, physicians, and the general public about the risks associated with stem cell tourism are mounting. Initial studies examining the perceptions of patients who have pursued stem cell tourism indicate many are highly critical of the research and regulatory systems in their home countries and believe them to be stagnant and unresponsive to patient needs. We suggest that educational material should include an explanation of the translational research process, in addition to other aspects of stem cell tourism, as one means to help promote greater understanding and, ideally, curb patient demand for unproven stem cell interventions. The material provided must stress that strong scientific research is required in order for therapies to be safe and have a greater chance at being effective. Through an analysis of educational material on stem cell tourism and translational stem cell research from patient groups and scientific societies, we describe essential elements that should be conveyed in educational material provided to patients. Although we support the broad dissemination of educational material on stem cell translational research, we also acknowledge that education may simply not be enough to engender patient and public trust in domestic research and regulatory systems. However, promoting patient autonomy by providing good quality information to patients so they can make better informed decisions is valuable in itself, irrespective of whether it serves as an effective deterrent of stem cell tourism. © 2013 American Society of Law, Medicine & Ethics, Inc.

  1. Insights from Ayurveda for translational stem cell research.

    Science.gov (United States)

    Joshi, Kalpana S; Bhonde, Ramesh

    2014-01-01

    Ayurveda, the traditional Indian system of medicine has given great emphasis to the promotion of health. Ayurveda therapies are based on restoration of body balance and nourishment of dhatus or tissues. Rasayana concept of Ayurveda explains tissue regeneration and cell renewal. The drugs and therapies explained as rasayana provide research opportunities for biology of regeneration. Specific rasayana stimulate and nourish respective dhatus. Interpretation of this description offers clues for specific differentiation of stem cells with appropriate extract. The preliminary experiments on Medhya drugs suggest neuronal stem cells differentiation. Authors highlight the potential of Ayurveda and its possible contributions in regenerative medicine. Authors propose a protocol based on integrative approach derived from Ayurveda concepts and current understanding of regenerative medicine. The advanced understanding about adult and embryonic stem cells along with concepts of regeneration in Ayurveda has immense potential in the development of regenerative medicine.

  2. Research Progress of Photoanodes for Quantum Dot Sensitized Solar Cells

    Directory of Open Access Journals (Sweden)

    LI Zhi-min

    2017-08-01

    Full Text Available This paper presents the development status and tendency of quantum dot sensitized solar cells. Photoanode research progress and its related technologies are analyzed in detail from the three ways of semiconductor thin films, quantum dot co-sensitization and quantum dot doping, deriving from the approach that the conversion efficiency can be improved by photoanode modification for quantum dot sensitized solar cells. According to the key factors which restrict the cell efficiency, the promising future development of quantum dot sensitized solar cells is proposed,for example,optimizing further the compositions and structures of semiconductor thin films for the photoanodes, exploring new quantum dots with broadband absorption and developing high efficient techniques of interface modification.

  3. Moving beyond "It Worked": The Ongoing Evolution of Research on Problem-Based Learning in Medical Education

    Science.gov (United States)

    Svinicki, Marilla D.

    2007-01-01

    Research on Problem-Based Learning in medical education has undergone an evolutionary process from initial proof of concept studies through critiques of the original methods and beyond. Initial studies focused on whether or not the instructional method was effective for medical students and the goals of medical education. Despite much movement…

  4. College Students' Conceptions of Stem Cells, Stem Cell Research, and Cloning

    Science.gov (United States)

    Concannon, James P.; Siegel, Marcelle A.; Halverson, Kristy; Freyermuth, Sharyn

    2010-04-01

    In this study, we examined 96 undergraduate non-science majors' conceptions of stem cells, stem cell research, and cloning. This study was performed at a large, Midwest, research extensive university. Participants in the study were asked to answer 23 questions relating to stem cells, stem cell research, and cloning in an on-line assessment before and after instruction. Two goals of the instruction were to: (1) help students construct accurate scientific ideas, and (2) enhance their reasoning about socioscientific issues. The course structure included interactive lectures, case discussions, hands-on activities, and independent projects. Overall, students' understandings of stem cells, stem cell research, and cloning increased from pre-test to post-test. For example, on the post-test, students gained knowledge concerning the age of an organism related to the type of stem cell it possesses. However, we found that some incorrect ideas that were evident on the pre-test persisted after instruction. For example, before and after instruction several students maintained the idea that stem cells can currently be used to produce organs.

  5. Induced Pluripotent Stem Cells in Huntington's Disease Research: Progress and Opportunity.

    Science.gov (United States)

    Tousley, Adelaide; Kegel-Gleason, Kimberly B

    2016-06-28

    Induced pluripotent stem cells (iPSCs) derived from controls and patients can act as a starting point for in vitro differentiation into human brain cells for discovery of novel targets and treatments for human disease without the same ethical limitations posed by embryonic stem cells. Numerous groups have successfully produced and characterized Huntington's disease (HD) iPSCs with different CAG repeat lengths, including cells from patients with one or two HD alleles. HD iPSCs and the neural cell types derived from them recapitulate some disease phenotypes found in both human patients and animal models. Although these discoveries are encouraging, the use of iPSCs for cutting edge and reproducible research has been limited due to some of the inherent problems with cell lines and the technological differences in the way laboratories use them. The goal of this review is to summarize the current state of the HD iPSC field, and to highlight some of the issues that need to be addressed to maximize their potential as research tools.

  6. Induced Pluripotent Stem Cells in Huntington’s Disease Research: Progress and Opportunity

    Science.gov (United States)

    Tousley, Adelaide; Kegel-Gleason, Kimberly B.

    2016-01-01

    Induced pluripotent stem cells (iPSCs) derived from controls and patients can act as a starting point for in vitro differentiation into human brain cells for discovery of novel targets and treatments for human disease without the same ethical limitations posed by embryonic stem cells. Numerous groups have successfully produced and characterized Huntington’s disease (HD) iPSCs with different CAG repeat lengths, including cells from patients with one or two HD alleles. HD iPSCs and the neural cell types derived from them recapitulate some disease phenotypes found in both human patients and animal models. Although these discoveries are encouraging, the use of iPSCs for cutting edge and reproducible research has been limited due to some of the inherent problems with cell lines and the technological differences in the way laboratories use them. The goal of this review is to summarize the current state of the HD iPSC field, and to highlight some of the issues that need to be addressed to maximize their potential as research tools. PMID:27372054

  7. STEM CELL RESEARCH DEVELOPMENT AND ITS PROTECTION IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Tomi Suryo Utomo

    2013-02-01

    Full Text Available This research discusses the possibility of patenting stem cells under the Indonesian patent law by focusing on two essential issues: (a what approaches should be chosen by the Indonesian government to protect stem cell research under the Indonesian Patent Act and non-patent regulations? and (b what types of stem cells can be protected under the Indonesian Patent Act? In order to provide comparative perspectives, this paper discusses the experience and policies of the US, German and South Korean governments in protecting stem cell research under their patent acts. Penelitian ini mendiskusikan kemungkinan mematenkan sel punca dalam hukum paten di Indonesia dengan memfokuskan pada dua isu pokok: (a Pendekatan apa yang sebaiknya dipilih oleh pemerintahan Indonesia untuk melindungi penelitian sel punca dalam hukum paten Indonesia dan peraturan non paten? (b Tipe sel punca apa yang dapat dilindungi dalam hukum paten Indonesia? Untuk mencakupi pendekatan melalui perbandingan dengan luar negeri, penelitian ini membahas pengalaman dan kebijakan di pemerintahan AS, Jerman, dan Korea Selatan dalam melindungi penelitan sel punca dalam hukum paten masing-masing negara.

  8. [Impact of DSM-5: Application and Problems Based on Clinical and Research Viewpoints on Anxiety Disorders].

    Science.gov (United States)

    Shioiri, Toshiki

    2015-01-01

    of fears from two or more agoraphobia-related situations is now required, because this is a robust means for distinguishing agoraphobia from specific phobias. Also, the criteria for agoraphobia are now extended to be consistent with criteria sets for other anxiety disorders (e.g., a clinician's judgment of the fears as being out of proportion to the actual danger in the situation, with a typical duration of 6 months or more). From the above, these changes from DSM-IV-TR to DSM-5 in anxiety disorders make our judgments faster and more efficient in clinical practice, and DSM-5 is more useful to elucidate the pathology. In this manuscript, we discuss the application and problems based on clinical and research viewpoints regarding anxiety disorders in DSM-5.

  9. Cauchy problem for multiscale conservation laws: Application to structured cell populations

    CERN Document Server

    Shang, Peipei

    2010-01-01

    In this paper, we study a vector conservation law that models the growth and selection of ovarian follicles. During each ovarian cycle, only a definite number of follicles ovulate, while the others undergo a degeneration process called atresia. This work is motivated by a multiscale mathematical model starting on the cellular scale, where ovulation or atresia result from a hormonally controlled selection process. A two-dimensional conservation law describes the age and maturity structuration of the follicular cell populations. The densities intersect through a coupled hyperbolic system between different follicles and cell phases, which results in a vector conservation law and coupling boundary conditions. The maturity velocity functions possess both a local and nonlocal character. We prove the existence and uniqueness of the weak solution to the Cauchy problem with bounded initial and boundary data.

  10. A stochastic model for the cell formation problem considering machine reliability

    Science.gov (United States)

    Esmailnezhad, Bahman; Fattahi, Parviz; Kheirkhah, Amir Saman

    2015-03-01

    This paper presents a new mathematical model to solve cell formation problem in cellular manufacturing systems, where inter-arrival time, processing time, and machine breakdown time are probabilistic. The objective function maximizes the number of operations of each part with more arrival rate within one cell. Because a queue behind each machine; queuing theory is used to formulate the model. To solve the model, two metaheurstic algorithms such as modified particle swarm optimization and genetic algorithm are proposed. For the generation of initial solutions in these algorithms, a new heuristic method is developed, which always creates feasible solutions. Both metaheurstic algorithms are compared against global solutions obtained from Lingo software's branch and bound (B&B). Also, a statistical method will be used for comparison of solutions of two metaheurstic algorithms. The results of numerical examples indicate that considering the machine breakdown has significant effect on block structures of machine-part matrixes.

  11. A survey of waterfowl problems in Alaska for the purpose of identifying research needs: Preliminary draft

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report highlights the many and varied problems facing the waterfowl resource of Alaska. Current waterfowl investigations and management programs aimed at...

  12. Problems and Solutions in Human Resources Management of Family Business: A Research in Konya City

    Directory of Open Access Journals (Sweden)

    Sefa CETIN

    2016-06-01

    Full Text Available The constant progress of the socio-economic development in our time has triggered competition worldwide which makes industrial and commercial establishments divert to human resources in order to distinguish themselves and survive. Family businesses both in Turkey and other countries, therefore, apply to HRM so as to overcome such problems deriving from their structures. This study tackles the family business that faces the problems in HRM and finds the solution to these problems. Studies show that companies who efficiently benefit from the principles of human resources have made remarkable headway. Additionally the family businesses which benefit from HRM and functions can solve the structural problems and catch the successful and institutionalized line.

  13. RESEARCH ON SOME THEORETICAL PROBLEMS OF MAP DATA HANDLING USING FRACTAL APPROACH

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Some theoretical problems of fractal geographical map data handling are dis cussed and some new methods about fractal dimension introducing, developing, comparing and estimating are proposed in this paper.

  14. Giant cell tumors of lower end of the radius : Problems and solutions

    Directory of Open Access Journals (Sweden)

    Dhammi I

    2005-01-01

    Full Text Available Background: Giant cell tumors of bone are aggressive, potentially malignant lesions. Juxtaarticular giant cell tumours of lower end radius are common and present a special problem of reconstruction after tumor excision. Out of the various reconstructive procedures described, use of nonvascularised fibular autograft has been widely used with satisfactory functional results. Methods: Sixteen patients with a mean age of 20.2 years, with either Campanacci grade II or III histologically proven giant cell tumours of lower end radius were treated with wide excision and reconstruction with ipsilateral nonvascularised proximal fibular autograft. Host graft junction was fixed with intramedullary nail in 12 cases and DCP in last 4 cases. Wrist ligament reconstruction and fixation of the head of fibula with carpal bones using K-wires and primary cancellous iliac crest grafting at graft host junction with DCP was done in last 2 cases. Results: The follow up ranges from 2 - 5 years (mean 3.5 years. At last follow up, the average combined range of motion was 110° with range varying from 60-125°. The average grip strength was 39% in comparison to the contralateral side (range 21-88%. The average union time was 8 months (range 4-12 months. Sound union occurred in 5 months, where DCPs were used. There were 5 nonunions, one resorption of graft, 10 wrist subluxations (2 painful, one recurrence, 3 superficial infections, one wound dehiscence and one amputation. There was no case of graft fracture, metastasis, death or significant donor site morbidity. A total of 10 secondary procedures were required. Conclusions: Enbloc resection of giant cell tumours of lower end radius is a widely accepted method. Reconstruction with nonvascularised fibular graft, internal fixation with DCP with primary corticocancellous bone grafting with transfixation of the fibular head and wrist ligament reconstruction minimizes the problem and gives satisfactory functional results.

  15. Small-Cell Lung Cancer: Clinical Management and Unmet Needs New Perspectives for an Old Problem.

    Science.gov (United States)

    Lo Russo, Giuseppe; Macerelli, Marianna; Platania, Marco; Zilembo, Nicoletta; Vitali, Milena; Signorelli, Diego; Proto, Claudia; Ganzinelli, Monica; Gallucci, Rosaria; Agustoni, Francesco; Fasola, Gianpiero; de Braud, Filippo; Garassino, Marina Chiara

    2017-01-01

    Small cell lung cancer is a highly aggressive, difficult to treat neoplasm. Among all lung tumors, small cell lung cancers account for about 20%. Patients typically include heavy smokers in 70s age group, presenting with symptoms such as intrathoracic tumors growth, distant spread or paraneoplastic syndromes at the time of diagnosis. A useful and functional classification divides small cell lung cancers into limited disease and extensive disease. Concurrent chemo-radiotherapy is the standard treatment for limited disease, with improved survival when combined with prophylactic cranial irradiation. Platinum compounds (cisplatin/carboplatin) plus etoposide remain the cornerstone for extensive disease. Nevertheless, despite high chemo- and radio-sensitivity of this cancer, nearly all patients relapse within the first two years and the prognosis is extremely poor. A deeper understanding about small cell lung cancer carcinogenesis led to develop and test a considerable number of new and targeted agents but the results are currently weak or insufficient. To date, small cell lung cancer is still a challenge for researchers. In this review, key aspects of small cell lung cancer management and controversial points of standard and new treatments will be discussed.

  16. Community problem-solving framed as a distributed information use environment: bridging research and practice

    Directory of Open Access Journals (Sweden)

    Joan C. Durrance

    2006-01-01

    Full Text Available Introduction. This article results from a qualitative study of 1 information behavior in community problem-solving framed as a distributed information use environment and 2 approaches used by a best-practice library to anticipate information needs associated with community problem solving. Method. Several approaches to data collection were used - focus groups, interviews, observation of community and library meetings, and analysis of supporting documents. We focused first on the information behaviour of community groups. Finding that the library supported these activities we sought to understand its approach. Analysis. Data were coded thematically for both information behaviour concepts and themes germane to problem-solving activity. A grounded theory approach was taken to capture aspects of the library staff's practice. Themes evolved from the data; supporting documentation - reports, articles and library communication - was also coded. Results. The study showed 1 how information use environment components (people, setting, problems, problem resolutions combine in this distributed information use environment to determine specific information needs and uses; and 2 how the library contributed to the viability of this distributed information use environment. Conclusion. Community problem solving, here explicated as a distributed IUE, is likely to be seen in multiple communities. The library model presented demonstrates that by reshaping its information practice within the framework of an information use environment, a library can anticipate community information needs as they are generated and where they are most relevant.

  17. Research on Software-Cell-Based Software System

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The aim of research on software architecture is to improve the quality attributes of software sys tems, such as security, reliability, maintainability, testability , reassembility , evolvability. However, a sin gle running system is hard to achieve all these goals. In this paper, software-cell is introduced as the basic u nit throughout developing process. Then it is further advanced that a robust, safe and high-quality software system is composed of a running system and four supportive systems. This paper especially discusses the structure of software-cell, the construction of the five systems, and the relations between them.

  18. Gravity research on plants: use of single cell experimental models

    Directory of Open Access Journals (Sweden)

    Youssef eChebli

    2011-09-01

    Full Text Available Future space missions and implementation of permanent bases on Moon and Mars will greatly depend on the availability of ambient air and sustainable food supply. Therefore, understanding the effects of altered gravity conditions on plant metabolism and growth is vital for space missions and extra-terrestrial human existence. In this mini-review we summarize how plant cells are thought to perceive changes in magnitude and orientation of the gravity vector. The particular advantages of several single celled model systems for gravity research are explored and an overview over recent advancements and potential use of these systems is provided.

  19. Stem Cells: A Renaissance in Human Biology Research.

    Science.gov (United States)

    Wu, Jun; Izpisua Belmonte, Juan Carlos

    2016-06-16

    The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological innovations, such as single cell "omics" and human stem cell derivation, have now greatly accelerated our ability to gain insights into uniquely human biology. The opportunities afforded to delve molecularly into scarce material and to model human embryogenesis and pathophysiological processes are leading to new insights of human development and are changing our understanding of disease and choice of therapy options.

  20. Qualitative Research as Policy Knowledge: Framing Policy Problems and Transforming Education from the Ground Up

    Science.gov (United States)

    Dumas, Michael J.; Anderson, Gary

    2014-01-01

    As educational research becomes privatized, commodified and commercialized, research relevance increasingly means being incorporated into neoliberal ideological and economic agendas. Within this social context, qualitative research in particular is often deemed less relevant (if not irrelevant) because it does not provide prescriptions for best…

  1. Using Working Agreements in Participatory Action Research: Working through Moral Problems with Malaysian Students

    Science.gov (United States)

    Balakrishnan, Vishalache; Cornforth, Sue

    2013-01-01

    In this paper we propose that taking time before the work begins to develop agreements about how to work together in participatory action research enables researchers to directly address several ethical issues that can be problematic in this type of research: gaining fully informed consent; in-group confidentiality; cultural misconceptions; and…

  2. Survey of editors and reviewers of high-impact psychology journals: statistical and research design problems in submitted manuscripts.

    Science.gov (United States)

    Harris, Alex; Reeder, Rachelle; Hyun, Jenny

    2011-01-01

    The authors surveyed 21 editors and reviewers from major psychology journals to identify and describe the statistical and design errors they encounter most often and to get their advice regarding prevention of these problems. Content analysis of the text responses revealed themes in 3 major areas: (a) problems with research design and reporting (e.g., lack of an a priori power analysis, lack of congruence between research questions and study design/analysis, failure to adequately describe statistical procedures); (b) inappropriate data analysis (e.g., improper use of analysis of variance, too many statistical tests without adjustments, inadequate strategy for addressing missing data); and (c) misinterpretation of results. If researchers attended to these common methodological and analytic issues, the scientific quality of manuscripts submitted to high-impact psychology journals might be significantly improved.

  3. Cost Effective Polymer Solar Cells Research and Education

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Sam-Shajing [Norfolk State Univ, Norfolk, VA (United States)

    2015-10-13

    The technical or research objective of this project is to investigate and develop new polymers and polymer based optoelectronic devices for potentially cost effective (or cost competitive), durable, lightweight, flexible, and high efficiency solar energy conversion applications. The educational objective of this project includes training of future generation scientists, particularly young, under-represented minority scientists, working in the areas related to the emerging organic/polymer based solar energy technologies and related optoelectronic devices. Graduate and undergraduate students will be directly involved in scientific research addressing issues related to the development of polymer based solar cell technology.

  4. Open science, e-science and the new technologies: Challenges and old problems in qualitative research in the social sciences

    Directory of Open Access Journals (Sweden)

    Ercilia García-Álvarez

    2012-12-01

    Full Text Available Purpose: As well as introducing the articles in the special issue titled "Qualitative Research in the Social Sciences", this article reviews the challenges, problems and main advances made by the qualitative paradigm in the context of the new European science policy based on open science and e-Science and analysis alternative technologies freely available in the 2.0 environment and their application to fieldwork and data analysis. Design/methodology: Theoretical review. Practical implications: The article identifies open access technologies with applications in qualitative research such as applications for smartphones and tablets, web platforms and specific qualitative data analysis software, all developed in both the e-Science context and the 2.0 environment. Social implications: The article discusses the possible role to be played by qualitative research in the open science and e-Science context and considers the impact of this new context on the size and structure of research groups, the development of truly collaborative research, the emergence of new ethical problems and quality assessment in review processes in an open environment. Originality/value: The article describes the characteristics that define the new scientific environment and the challenges posed for qualitative research, reviews the latest open access technologies available to researchers in terms of their main features and proposes specific applications suitable for fieldwork and data analysis.

  5. Cell-centered nonlinear finite-volume methods for the heterogeneous anisotropic diffusion problem

    Science.gov (United States)

    Terekhov, Kirill M.; Mallison, Bradley T.; Tchelepi, Hamdi A.

    2017-02-01

    We present two new cell-centered nonlinear finite-volume methods for the heterogeneous, anisotropic diffusion problem. The schemes split the interfacial flux into harmonic and transversal components. Specifically, linear combinations of the transversal vector and the co-normal are used that lead to significant improvements in terms of the mesh-locking effects. The harmonic component of the flux is represented using a conventional monotone two-point flux approximation; the component along the parameterized direction is treated nonlinearly to satisfy either positivity of the solution as in [29], or the discrete maximum principle as in [9]. In order to make the method purely cell-centered, we derive a homogenization function that allows for seamless interpolation in the presence of heterogeneity following a strategy similar to [46]. The performance of the new schemes is compared with existing multi-point flux approximation methods [3,5]. The robustness of the scheme with respect to the mesh-locking problem is demonstrated using several challenging test cases.

  6. HISTORICAL-PEDAGOGICAL ANALYSIS OF THE PROBLEM OF DEVELOPING RESEARCH SKILLS IN STUDENTS, AS A FACTOR IN EFFECTIVE LEARNING

    Directory of Open Access Journals (Sweden)

    Marianna Albertovna Gorodilova

    2016-02-01

    Full Text Available A special form of the process of cognition this study, i.e. targeted and systematic study that uses the tools of science, and which results in the formation of knowledge about the studied objects. In a broad sense, research is the search for new knowledge. On the other hand (in the narrow sense research is a scientific method of studying something. Cognitive abilities of students based on the ability to «explore».The aim of our study is the problem of formation and development of research skills among students. These skills characterize many kinds of activities corresponding to different levels of professionalism. The development of research skills determines the success of the training. Methodical skill of the teacher is manifested, not only in dealing with certain tasks of teaching, but rather in how these tasks are solved. Without knowledge of historical and pedagogical heritage is impossible to solve the problem of development of research skills in the students.The article conducts historical and pedagogical analysis of literary sources on the problem of developing research skills in students. Considered certain periods in the formation process of formation and development of research abilities of students during their education. This idea existed not in isolation, but in the General system of other Sciences, especially mathematics and philosophy and relevant is not a single century. Changing pedagogical approaches to the implementation of this idea, as changing the conditions of teaching and the individual characteristics of students. But to form and develop in students the ability to think independently, implement research – one of methods of successful training.

  7. Commentary on: Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research. Problems with atheoretical and confirmatory research approaches in the study of behavioral addictions.

    Science.gov (United States)

    Kardefelt-Winther, Daniel

    2015-09-01

    This commentary is written in response to a paper by Billieux, Schimmenti, Khazaal, Maurage and Hereen (2015) published in the Journal of Behavioral Addictions. It supports and extends the arguments by Billieux, Schimmenti et al. (2015): that the study of behavioral addictions too often rests on atheoretical and confirmatory research approaches. This tends to lead to theories that lack specificity and a neglect of the underlying processes that might explain why repetitive problem behaviors occur. In this commentary I extend the arguments by Billieux, Schimmenti et al. (2015) and argue that such research approaches might take us further away from conceptualizing psychiatric diagnoses that can be properly validated, which is already a problem in the field. Furthermore, I discuss whether the empirical support for conceptualizing repetitive problem behaviors as addictions might rest on research practices that have been methodologically biased to produce a result congruent with the proposal that substance addictions and behavioral addictions share similar traits. I conclude by presenting a number of ways of going forward, chief of which is the proposal that we might wish to go beyond a priori assumptions of addiction in favor of identifying the essential problem manifestations for each new potential behavioral addiction.

  8. An action research inquiry into a health visitor parenting programme for parents of pre-school children with behaviour problems.

    Science.gov (United States)

    Kilgour, C; Fleming, V

    2000-09-01

    An action research inquiry into a health visitor parenting programme for parents of pre-school children with behaviour problems Parent education programmes have recently been given a high profile in this country, such provision deemed necessary because of the commonality of children's behaviour problems and because of their potentially far-reaching effects on the child, the family and society. This action research study, undertaken in Scotland, aims to explore a health visitor parenting programme for parents of pre-school children with behaviour problems. Within this study, children with behaviour problems were identified as those whose parents perceived them to have such problems, the children eliciting a wide range of behaviours and to varying degrees. Critical social science is the chosen methodology, since it allows exploration of how people comprehend their social reality. Group interactions were recorded on audio-tape and themes associated with the methodology of enlightenment, empowerment and emancipation were identified. The results of the study demonstrate how a liberating, collaborative approach to parental education can empower mothers, by increasing understanding and raising self-esteem.

  9. Single cell analysis contemporary research and clinical applications

    CERN Document Server

    Cossarizza, Andrea

    2017-01-01

    This book highlights the current state of the art in single cell analysis, an area that involves many fields of science – from clinical hematology, functional analysis and drug screening, to platelet and microparticle analysis, marine biology and fundamental cancer research. This book brings together an eclectic group of current applications, all of which have a significant impact on our current state of knowledge. The authors of these chapters are all pioneering researchers in the field of single cell analysis. The book will not only appeal to those readers more focused on clinical applications, but also those interested in highly technical aspects of the technologies. All of the technologies identified utilize unique applications of photon detection systems.

  10. Human cloning, stem cell research. An Islamic perspective.

    Science.gov (United States)

    Al-Aqeel, Aida I

    2009-12-01

    The rapidly changing technologies that involve human subjects raise complex ethical, legal, social, and religious issues. Recent advances in the field of cloning and stem cell research have introduced new hopes for the treatment of serious diseases. But this promise has raised many complex questions. This field causes debate and challenge, not only among scientists but also among ethicists, religious scholars, governments, and politicians. There is no consensus on the morality of human cloning, even within specific religious traditions. In countries in which religion has a strong influence on political decision making, the moral status of the human embryo is at the center of the debate. Because of the inevitable consequences of reproductive cloning, it is prohibited in Islam. However, stem cell research for therapeutic purposes is permissible with full consideration, and all possible precautions in the pre-ensoulment stages of early fetus development, if the source is legitimate.

  11. Solving the influence maximization problem reveals regulatory organization of the yeast cell cycle.

    Directory of Open Access Journals (Sweden)

    David L Gibbs

    2017-06-01

    Full Text Available The Influence Maximization Problem (IMP aims to discover the set of nodes with the greatest influence on network dynamics. The problem has previously been applied in epidemiology and social network analysis. Here, we demonstrate the application to cell cycle regulatory network analysis for Saccharomyces cerevisiae. Fundamentally, gene regulation is linked to the flow of information. Therefore, our implementation of the IMP was framed as an information theoretic problem using network diffusion. Utilizing more than 26,000 regulatory edges from YeastMine, gene expression dynamics were encoded as edge weights using time lagged transfer entropy, a method for quantifying information transfer between variables. By picking a set of source nodes, a diffusion process covers a portion of the network. The size of the network cover relates to the influence of the source nodes. The set of nodes that maximizes influence is the solution to the IMP. By solving the IMP over different numbers of source nodes, an influence ranking on genes was produced. The influence ranking was compared to other metrics of network centrality. Although the top genes from each centrality ranking contained well-known cell cycle regulators, there was little agreement and no clear winner. However, it was found that influential genes tend to directly regulate or sit upstream of genes ranked by other centrality measures. The influential nodes act as critical sources of information flow, potentially having a large impact on the state of the network. Biological events that affect influential nodes and thereby affect information flow could have a strong effect on network dynamics, potentially leading to disease. Code and data can be found at: https://github.com/gibbsdavidl/miergolf.

  12. Solving the influence maximization problem reveals regulatory organization of the yeast cell cycle

    Science.gov (United States)

    Shmulevich, Ilya

    2017-01-01

    The Influence Maximization Problem (IMP) aims to discover the set of nodes with the greatest influence on network dynamics. The problem has previously been applied in epidemiology and social network analysis. Here, we demonstrate the application to cell cycle regulatory network analysis for Saccharomyces cerevisiae. Fundamentally, gene regulation is linked to the flow of information. Therefore, our implementation of the IMP was framed as an information theoretic problem using network diffusion. Utilizing more than 26,000 regulatory edges from YeastMine, gene expression dynamics were encoded as edge weights using time lagged transfer entropy, a method for quantifying information transfer between variables. By picking a set of source nodes, a diffusion process covers a portion of the network. The size of the network cover relates to the influence of the source nodes. The set of nodes that maximizes influence is the solution to the IMP. By solving the IMP over different numbers of source nodes, an influence ranking on genes was produced. The influence ranking was compared to other metrics of network centrality. Although the top genes from each centrality ranking contained well-known cell cycle regulators, there was little agreement and no clear winner. However, it was found that influential genes tend to directly regulate or sit upstream of genes ranked by other centrality measures. The influential nodes act as critical sources of information flow, potentially having a large impact on the state of the network. Biological events that affect influential nodes and thereby affect information flow could have a strong effect on network dynamics, potentially leading to disease. Code and data can be found at: https://github.com/gibbsdavidl/miergolf. PMID:28628618

  13. Research on problem solving skills of orienteering athletes in terms of some variables

    Directory of Open Access Journals (Sweden)

    Eroğlu Başak

    2016-01-01

    Full Text Available The aim of this study is to examine the problem solving skills of orienteering athletes in terms of different variables. 157 male and 43 female orienteering athletes, making a total of 200 athletes that joined the 3rd Level of Turkey Championship in 2015 have participated in this study which is in a survey model. The data collection tools were the Problem Solving Inventory and Personal Information Form that were formed by Heppner & Peterson (1982 and adapted into Turkish by Şahin, Şahin & Heppner (1993. In the data analysis, descriptive statics, anova, t test and Tukey test have been utilized. In the line with the findings, it has been determined that the difference between the total mean values (85.55+20.45 that the orienteering athletes got from the problem solving inventory and their age, marital status, sports age, the years of practice in orienteering sports, and the status of being national player is significant (p<0.05. It has been found that male orienteering athletes perform higher evaluating approach compared to the female athletes, and that as the age levels increase, the problem solving skill is affected more positively. Furthermore, it has been determined that the perceptions of the participants that have more experience and sports age in orienteering sports and that do orienteering sports at a national level are more positive in the matter of problem solving skills.

  14. Ethical issues in implementation research: a discussion of the problems in achieving informed consent

    Directory of Open Access Journals (Sweden)

    Eccles Martin P

    2008-12-01

    Full Text Available Abstract Background Improved quality of care is a policy objective of health care systems around the world. Implementation research is the scientific study of methods to promote the systematic uptake of clinical research findings into routine clinical practice, and hence to reduce inappropriate care. It includes the study of influences on healthcare professionals' behaviour and methods to enable them to use research findings more effectively. Cluster randomized trials represent the optimal design for evaluating the effectiveness of implementation strategies. Various codes of medical ethics, such as the Nuremberg Code and the Declaration of Helsinki inform medical research, but their relevance to cluster randomised trials in implementation research is unclear. This paper discusses the applicability of various ethical codes to obtaining consent in cluster trials in implementation research. Discussion The appropriate application of biomedical codes to implementation research is not obvious. Discussion of the nature and practice of informed consent in implementation research cluster trials must consider the levels at which consent can be sought, and for what purpose it can be sought. The level at which an intervention is delivered can render the idea of patient level consent meaningless. Careful consideration of the ownership of information, and rights of access to and exploitation of data is required. For health care professionals and organizations, there is a balance between clinical freedom and responsibility to participate in research. Summary While ethical justification for clinical trials relies heavily on individual consent, for implementation research aspects of distributive justice, economics, and political philosophy underlie the debate. Societies may need to trade off decisions on the choice between individualized consent and valid implementation research. We suggest that social sciences codes could usefully inform the consideration of

  15. A simulation based research on chance constrained programming in robust facility location problem

    Science.gov (United States)

    Kaijun, Leng; Wen, Shi; Guanghua, Song; Lin, Pan

    2017-03-01

    Since facility location decisions problem include long-term character and potential parameter variations, it is important to consider uncertainty in its modeling. This paper examines robust facility location problem considering supply uncertainty, in which we assume the supply of the facility in the actual operation is not equal to the supply initially established, the supply is subject to random fluctuation. The chance constraints are introduced when formulating the robust facility location model to make sure the system operate properly with a certain probability while the supply fluctuates. The chance constraints are approximated safely by using Hoeffding's inequality and the problem is transformed to a general deterministic linear programming. Furthermore, how the facility location cost change with confidence level is investigated through a numerical example. The sensitivity analysis is conducted for important parameters of the model and we get the main factors that affect the facility location cost.

  16. Research on multi-objective emergency logistics vehicle routing problem under constraint conditions

    Directory of Open Access Journals (Sweden)

    Miaomiao Du

    2013-03-01

    Full Text Available Purpose: Aim at choosing a relative good vehicle routing in emergency conditions under constraint conditions when disaster happens. Rapid response and rescue can save a lot of people. Design/methodology/approach: Modeling analysis: establishing a mathematical model of multi-objective emergency logistics vehicle routing problem. And in end of the paper, we intend to use genetic algorithms to solve the problem. Findings: Considering time requirement and cost limit both while choosing vehicle routing when the disasters happens is meaningful. We can get a relative good result and give a guidance to rescue teams. Originality/value: Consider cost and time objectives and kinds of realistic conditions (such as the road congestion in the model when solving the problem, having expanded the theory scope.

  17. 2012 PLANT CELL WALLS GORDON RESEARCH CONFERENCE AND GORDON RESEARCH SEMINAR, AUGUST 4-10, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Jocelyn

    2012-08-10

    The sub-theme of this year’s meeting, ‘Cell Wall Research in a Post-Genome World’, will be a consideration of the dramatic technological changes that have occurred in the three years since the previous cell wall Gordon Conference in the area of DNA sequencing. New technologies are providing additional perspectives of plant cell wall biology across a rapidly growing number of species, highlighting a myriad of architectures, compositions, and functions in both "conventional" and specialized cell walls. This meeting will focus on addressing the knowledge gaps and technical challenges raised by such diversity, as well as our need to understand the underlying processes for critical applications such as crop improvement and bioenergy resource development.

  18. Concise review: carbon nanotechnology: perspectives in stem cell research.

    Science.gov (United States)

    Pryzhkova, Marina V

    2013-05-01

    Carbon nanotechnology has developed rapidly during the last decade, and carbon allotropes, especially graphene and carbon nanotubes, have already found a wide variety of applications in industry, high-tech fields, biomedicine, and basic science. Electroconductive nanomaterials have attracted great attention from tissue engineers in the design of remotely controlled cell-substrate interfaces. Carbon nanoconstructs are also under extensive investigation by clinical scientists as potential agents in anticancer therapies. Despite the recent progress in human pluripotent stem cell research, only a few attempts to use carbon nanotechnology in the stem cell field have been reported. However, acquired experience with and knowledge of carbon nanomaterials may be efficiently used in the development of future personalized medicine and in tissue engineering.

  19. A problem-based approach to teaching research methodology to medical graduates in Iran

    Directory of Open Access Journals (Sweden)

    Mehrdad Jalalian Hosseini

    2009-08-01

    Full Text Available Physicians are reticent to participate in research projects for avariety of reasons. Facilitating the active involvement ofdoctors in research projects is a high priority for the IranianBlood Transfusion Organization (IBTO. A one-month trainingcourse on research methodology was conducted for a groupof physicians in Mashhad, in northeast Iran. The participantswere divided in ten groups. They prepared a researchproposal under the guidance of a workshop leader. Thequality of the research proposals, which were prepared by allparticipants, went beyond our expectations. All of theresearch proposals were relevant to blood safety. In this briefreport we describe our approach.

  20. 'Nursing research culture' in the context of clinical nursing practice: addressing a conceptual problem.

    Science.gov (United States)

    Berthelsen, Connie Bøttcher; Hølge-Hazelton, Bibi

    2017-05-01

    To report an analysis of the concept of nursing research culture in the context of clinical nursing practice. Nursing research culture should be valued for its contribution to improving patient care and should be considered as a routine hospital activity. However, the demand for efficiency, nurses' barriers to research use and the lack of definition of the concept of nursing research culture make it difficult to establish. Concept analysis. Data were collected through a literature review in PubMed, CINAHL and PsycINFO during March 2016. Walker and Avant's eight-step framework for concept analysis. Five defining attributes of nursing research culture in the context of clinical nursing practice were identified: strong monodisciplinary nursing professionalism, academic thinking and socialization, research use as a part of daily nursing practice, acceptance by colleagues and management and facilitation of resources from management and organization. Although the method of concept analysis has been criticized and heavily debated, the development of nursing research cultures based on the defining attributes and antecedents of the concept will be important to emphasize evidence-based clinical nursing care. Further research should support the development and the implementation of nursing research culture in clinical nursing practice. © 2016 John Wiley & Sons Ltd.

  1. Enrichment and Function Research of Large Cell Lung Cancer Stem Cell-like Cells

    Directory of Open Access Journals (Sweden)

    Wenke YUE

    2011-06-01

    Full Text Available Background and objective There are no universal method to recognize and screen for lung cancer stem cell markers and indicators. Commonly used methods are flow Cytometry and learning from other cancer stem cell sorting tags to sort lung cancer stem cells. But this method has low specificity screening, the workload is huge. In this study, Serum-free suspension culture was used to enrich lung cancer stem cells, and explore method for lung cancer stem cell screening. Methods Human large lung cancer cell line-L9981 was cultured in serum-free and growth factors added medium, and spheres were obtained. Then the morphological differences of sphere cells and adherent L9981 cells cultured in serum-containing mediums are observed. Cell proliferation was analyzed by Vi-cell viability analyzer; invasion ability was tested by transwell assay; and in vivo tumorigenicity of the two groups of cells was studied in nude mouse. Results Compared with adherent L9981 cells cultured in serum-containing mediums, cells cultured in serum-free medium display sphere appearance. Doubling time of adherent cells and sphere cells are (56.05±1.95 h and (33.00±1.44 h respectively; Spheroid cells had higher invasion and tumorigenicity ability, 5 times and 20 times respectively, than adherent cells. Conclusion Suspension cultured L9981 in Serum-free medium could form spheroid populations. Cells in spheres had higher ability of invasion and Tumorigenicity than adherent L9981 cells. These results indicated spheroid L9981 cells contained enriched lung cancer stem cells, and Serum-free suspension culture can be a candidate method for enriching lung cancer stem cell.

  2. Black boxes on wheels: research challenges and ethical problems in MEA-based robotics

    DEFF Research Database (Denmark)

    Bentzen, Martin Mose

    2016-01-01

    Robotic systems consisting of a neuron culture grown on a multielectrode array (MEA) which is connected to a virtual or mechanical robot have been studied for approximately 15 years. It is hoped that these MEA-based robots will be able to address the problem that robots based on conventional comp...

  3. Maintaining a permanent plot data base for growth and yield research: Solutions to some recurring problems

    Science.gov (United States)

    John C. Byrne

    1993-01-01

    Methods for solving some recurring problems of maintaining a permanent plot data base for growth and yield reseuch are described. These methods include documenting data from diverse sampling designs, changing sampling designs, changing field procedures, and coordinating activities in the plots with the land management agency. Managing a permanent plot data base (...

  4. Exploring quantum mechanics a collection of 700+ solved problems for students, lecturers, and researchers

    CERN Document Server

    Galitski, Victor; Kogan, Vladimir; Galitski, Victor Jr

    2013-01-01

    A series of seminal technological revolutions has led to a new generation of electronic devices miniaturized to such tiny scales where the strange laws of quantum physics come into play. There is no doubt that, unlike scientists and engineers of the past, technology leaders of the future will have to rely on quantum mechanics in their everyday work. This makes teaching and learning the subject of paramount importance for further progress. Mastering quantum physics is a very non-trivial task and its deep understanding can only be achieved through working out real-life problems and examples. It is notoriously difficult to come up with new quantum-mechanical problems that would be solvable with a pencil and paper, and within a finite amount of time. This book remarkably presents some 700+ original problems in quantum mechanics together with detailed solutions covering nearly 1000 pages on all aspects of quantum science. The material is largely new to the English-speaking audience. The problems have been collect...

  5. Information problem solving instruction: An overview of 21st century research

    NARCIS (Netherlands)

    Wopereis, Iwan; Frerejean, Jimmy; Testers, Laurent; Van Strien, Johan; Walhout, Jaap; Brand-Gruwel, Saskia

    2015-01-01

    Information problem solving (IPS) is the process of locating, selecting, evaluating, and integrating information from various sources to fulfill an information need (Brand-Gruwel, Wopereis, & Vermetten, 2005). It is regarded an important contemporary skill, at times categorized as twenty-first centu

  6. Microcomputers and Evaluation Research: Potential Benefits and Problems. Paper and Report Series, No. 98.

    Science.gov (United States)

    Gray, Peter J.

    This paper deals with two questions: (1) what are the the applications that might be made of microcomputers in evaluation? and (2) what are the kinds of problems (personnel, organizational, and technical) that must be overcome if microcomputers are to be used effectively? The applications include proposals and planning, management, data…

  7. Problem-Based Learning and Action Research in Postgraduate Teaching: The Interdisciplinary Core

    Science.gov (United States)

    Servan, M. J.; Soto, E.; Murillo, J. F.; Sola, M.; Perez, A. I.

    2009-01-01

    The purpose of this article is to describe innovatory online teaching carried out in the inter-university master's "Educational Innovation Policies and Practices for the Knowledge Society", with the participation of Malaga, Almeria and Internacional de Andalucia Universities. The master's focuses on the exploration of a problem-based…

  8. Ecosystem services and cooperative fisheries research to address a complex fishery problem

    Science.gov (United States)

    The St. Louis River represents a complex fishery management problem. Current fishery management goals have to be developed taking into account bi-state commercial, subsistence and recreational fisheries which are valued for different characteristics by a wide range of anglers, as...

  9. Information problem solving instruction: An overview of 21st century research

    NARCIS (Netherlands)

    Wopereis, Iwan; Frerejean, Jimmy; Testers, Laurent; Van Strien, Johan; Walhout, Jaap; Brand-Gruwel, Saskia

    2015-01-01

    Information problem solving (IPS) is the process of locating, selecting, evaluating, and integrating information from various sources to fulfill an information need (Brand-Gruwel, Wopereis, & Vermetten, 2005). It is regarded an important contemporary skill, at times categorized as twenty-first

  10. The Problem of Correspondence of Educational and Professional Standards (Results of Empirical Research)

    Science.gov (United States)

    Piskunova, Elena; Sokolova, Irina; Kalimullin, Aydar

    2016-01-01

    In the article, the problem of correspondence of educational standards of higher pedagogical education and teacher professional standards in Russia is actualized. Modern understanding of the quality of vocational education suggests that in the process of education the student develops a set of competencies that will enable him or her to carry out…

  11. The global social problem : challenges for a Research School like CERES

    NARCIS (Netherlands)

    Dietz, A.J.

    2003-01-01

    The text starts with a reminder of the historical roots of the debate about the social problem in early industrial England, and connects it with the current debate about social exclusion and poverty, with an example from South Africa. Poverty issues should be related to the debates about labour cond

  12. Agent-Based Modeling of Collaborative Problem Solving. Research Report. ETS RR-16-27

    Science.gov (United States)

    Bergner, Yoav; Andrews, Jessica J.; Zhu, Mengxiao; Gonzales, Joseph E.

    2016-01-01

    Collaborative problem solving (CPS) is a critical competency in a variety of contexts, including the workplace, school, and home. However, only recently have assessment and curriculum reformers begun to focus to a greater extent on the acquisition and development of CPS skill. One of the major challenges in psychometric modeling of CPS is…

  13. The Rise and Fall of a Social Problem: Critical Reflections on Educational Policy and Research Issues

    Science.gov (United States)

    Franberg, Gun-Marie; Wrethander, Marie

    2012-01-01

    This article examines a growing and distressing social phenomenon, namely, bullying, the historical development, social dimensions, and political impact of which are taken into account and subjected to reflection and critical consideration. It describes both the progress of and problems with the concept of bullying. It also reflects on the…

  14. Bully/Victim Problems among Preschool Children: A Review of Current Research Evidence

    Science.gov (United States)

    Vlachou, Maria; Andreou, Eleni; Botsoglou, Kafenia; Didaskalou, Eleni

    2011-01-01

    Bullying in schools has been identified as a serious and complex worldwide problem associated with negative short- and long-term effects on children's psychosocial adjustment (Smith 1999; Ttofi and Farrington, "Aggressive Behav" 34(4):352-368, 2008). Entering kindergarten is a crucial developmental step in many children's lives mainly because it…

  15. Information problem solving instruction: An overview of 21st century research

    NARCIS (Netherlands)

    Wopereis, Iwan; Frerejean, Jimmy; Testers, Laurent; Van Strien, Johan; Walhout, Jaap; Brand-Gruwel, Saskia

    2015-01-01

    Information problem solving (IPS) is the process of locating, selecting, evaluating, and integrating information from various sources to fulfill an information need (Brand-Gruwel, Wopereis, & Vermetten, 2005). It is regarded an important contemporary skill, at times categorized as twenty-first centu

  16. Bully/Victim Problems among Preschool Children: A Review of Current Research Evidence

    Science.gov (United States)

    Vlachou, Maria; Andreou, Eleni; Botsoglou, Kafenia; Didaskalou, Eleni

    2011-01-01

    Bullying in schools has been identified as a serious and complex worldwide problem associated with negative short- and long-term effects on children's psychosocial adjustment (Smith 1999; Ttofi and Farrington, "Aggressive Behav" 34(4):352-368, 2008). Entering kindergarten is a crucial developmental step in many children's lives mainly because it…

  17. Use of Open-Ended Problems in Mathematics Classroom. Research Report 176.

    Science.gov (United States)

    Pehkonen, Erkki, Ed.

    During the years 1993-96, there has existed an active discussion group entitled "Using Open-Ended Problems in Mathematics" as a part of the scientific program of the Psychology of Mathematics Education (PME) conference. This report contains revised versions of presentations given in the discussion group. Since the PME is an international…

  18. Global competencies of regional stem cell research: bibliometrics for investigating and forecasting research trends.

    Science.gov (United States)

    Watatani, Kenji; Xie, Zhongquan; Nakatsuji, Norio; Sengoku, Shintaro

    2013-09-01

    We employed a bibliometric approach to examine regional stem cell research in the USA, the UK, Japan and China based on publications from 2007 to 2011 with a co-citation clustering analysis to identify region-specific clusters of global competencies. We observed that there are clear differences in the number and interdisciplinary spread of competencies across regions: the USA retains the largest capacity and capability for pursuing medical and pharmaceutical applications; China has shown substantial growth through fusion approaches with chemistry and material sciences; Japan has been pursuing basic biology and is currently seeking further growth; and the UK has shown considerable growth and quality with a focus on medical research and the widest interdisciplinary spread. Furthermore, we discuss policy implications from these results in terms of industrial and clinical applications. These findings provide a rational way of evaluating research policies and forecasting research trends.

  19. Adult neurogenesis, neural stem cells and Alzheimer's disease: developments, limitations, problems and promises.

    Science.gov (United States)

    Taupin, Philippe

    2009-12-01

    Alzheimer's disease (AD) is an irreversible progressive neurodegenerative disease, leading to severe incapacity and death. It is the most common form of dementia among older people. AD is characterized in the brain by amyloid plaques, neurofibrillary tangles, neuronal degeneration, aneuploidy and enhanced neurogenesis and by cognitive, behavioral and physical impairments. Inherited mutations in several genes and genetic, acquired and environmental risk factors have been reported as causes for developing the disease, for which there is currently no cure. Current treatments for AD involve drugs and occupational therapies, and future developments involve early diagnosis and stem cell therapy. In this manuscript, we will review and discuss the recent developments, limitations, problems and promises on AD, particularly related to aneuploidy, adult neurogenesis, neural stem cells (NSCs) and cellular therapy. Though adult neurogenesis may be beneficial for regeneration of the nervous system, it may underly the pathogenesis of AD. Cellular therapy is a promising strategy for AD. Limitations in protocols to establish homogeneous populations of neural progenitor and stem cells and niches for neurogenesis need to be resolved and unlocked, for the full potential of adult NSCs to be realized for therapy.

  20. Thin film polycrystalline silicon: Promise and problems in displays and solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Fonash, S.J. [Pennsylvania State Univ., University Park, PA (United States)

    1995-08-01

    Thin film polycrystalline Si (poly-Si) with its carrier mobilities, potentially good stability, low intragrain defect density, compatibility with silicon processing, and ease of doping activation is an interesting material for {open_quotes}macroelectronics{close_quotes} applications such as TFTs for displays and solar cells. The poly-Si films needed for these applications can be ultra-thin-in the 500{Angstrom} to 1000{Angstrom} thickness range for flat panel display TFTs and in the 4{mu}m to 10{mu}m thickness range for solar cells. Because the films needed for these microelectronics applications can be so thin, an effective approach to producing the films is that of crystallizing a-Si precursor material. Unlike cast materials, poly-Si films made this way can be produced using low temperature processing. Unlike deposited poly-Si films, these crystallized poly-Si films can have grain widths that are much larger than the film thickness and almost atomically smooth surfaces. This thin film poly-Si crystallized from a-Si precursor films, and its promise and problems for TFTs and solar cells, is the focus of this discussion.

  1. Problems in biology with many scales of length: Cell-cell adhesion and cell jamming in collective cellular migration.

    Science.gov (United States)

    Pegoraro, Adrian F; Fredberg, Jeffrey J; Park, Jin-Ah

    2016-04-10

    As do all things in biology, cell mechanosensation, adhesion and migration begin at the scale of the molecule. Collections of molecules assemble to comprise microscale objects such as adhesions, organelles and cells. And collections of cells in turn assemble to comprise macroscale tissues. From the points of view of mechanism and causality, events at the molecular scale are seen most often as being the most upstream and, therefore, the most fundamental and the most important. In certain collective systems, by contrast, events at many scales of length conspire to make contributions of equal importance, and even interact directly and strongly across disparate scales. Here we highlight recent examples in cellular mechanosensing and collective cellular migration where physics at some scale bigger than the cell but smaller than the tissue - the mesoscale - becomes the missing link that is required to tie together findings that might otherwise seem counterintuitive or even unpredictable. These examples, taken together, establish that the phenotypes and the underlying physics of collective cellular migration are far richer than previously anticipated. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. The Problem of Data in the Cognitive Linguistic Research on Metonymy: A Cross-Linguistic Perspective

    Science.gov (United States)

    Brdar-Szabo, Rita; Brdar, Mario

    2012-01-01

    The general goal of the present paper is to demonstrate how cross-linguistic (contrastive) data can broaden the perspective in cognitive linguistic research on metonymy, which may raise a host of questions calling for a revision of some widely accepted views. A more specific, methodological goal is to show how the introspection-driven research and…

  3. Introduction: The Incorporation Problem in Interdisciplinary Legal Research : Part 1: Theoretical Discussions

    NARCIS (Netherlands)

    H.S. Taekema (Sanne); W. van der Burg (Wibren)

    2015-01-01

    textabstractIn the past decades, there has been a rapid increase of interdisciplinary research with regard to law, exemplified in socio-legal research and law and economics. More recently, there has also been – albeit in some countries more than in others – a growing interest in the methodology of l

  4. Inter- and Transdisciplinary Work: Connecting Research on Hormones with Problems of Educational Practice

    Science.gov (United States)

    Rappolt-Schlichtmann, Gabrielle; Watamura, Sarah E.

    2010-01-01

    More than ever before, leaders within the field of education are looking to research on basic processes to inform and improve educational practices. Success requires building a reciprocal relationship between the field of education and research on learning and development, similar to what exists between biology and medicine. Key to this effort is…

  5. A Roadmap to Cope with Common Problems in E-Learning Research Designs

    Science.gov (United States)

    Sarsa, Javier; Escudero, Tomás

    2016-01-01

    E-learning research is plenty of difficulties, as also research in education is. Usually, the high number of features involved in e-learning processes complicates and masks the identification and isolation of the factors which cause the expected benefits, when they exist. At the same time, a bunch of threats are ready to weaken the validity of the…

  6. Ethical problems in health research with indigenous or originary peoples in Peru.

    Science.gov (United States)

    Minaya, Gabriela; Roque, Joel

    2015-07-01

    The varied, abrupt and amazing geography of the land of Peru is home of one of the major concentrations of indigenous peoples in the world. The asymmetry of power, however, in their relationship with the rest of society and the State is still very evident in their social exclusion, their gap in social and economic development, barriers in their access to health services as well as their marginalization and exploitation as subjects of health research. In this paper, we analyse two cases of research on indigenous populations in Peru, discuss them from the point of view of bioethics and reflect on important issues for researchers, research participants and the society, such as the need to respect different cultures, the need that the research being done is relevant to the needs of the population in which it is conducted and the necessity to empower indigenous communities in participatory research, to strengthen the institutions and to protect human rights, namely through ethics committees for research and the free, informed and meaningful informed consent. This approach should foster quality research, while at the same time fully respecting human rights and bioethics. We cannot forget that advancements in genetics, throughout the world, are very much in debt to indigenous populations.

  7. Research versus Problem Solving for the Education Leadership Doctoral Thesis: Implications for Form and Function

    Science.gov (United States)

    Archbald, Doug

    2008-01-01

    Background: A growing literature is questioning the appropriateness of a research dissertation for practitioners in education doctoral programs. Although this literature persuasively critiques the prevailing theory-research orientation of most programs and theses, it goes little beyond exhorting change and describing extant alternatives in a few…

  8. A mathematical approach to research problems of science and technology theoretical basis and developments in mathematical modeling

    CERN Document Server

    Ei, Shin-ichiro; Koiso, Miyuki; Ochiai, Hiroyuki; Okada, Kanzo; Saito, Shingo; Shirai, Tomoyuki

    2014-01-01

    This book deals with one of the most novel advances in mathematical modeling for applied scientific technology, including computer graphics, public-key encryption, data visualization, statistical data analysis, symbolic calculation, encryption, error correcting codes, and risk management. It also shows that mathematics can be used to solve problems from nature, e.g., slime mold algorithms. One of the unique features of this book is that it shows readers how to use pure and applied mathematics, especially those mathematical theory/techniques developed in the twentieth century, and developing now, to solve applied problems in several fields of industry. Each chapter includes clues on how to use "mathematics" to solve concrete problems faced in industry as well as practical applications. The target audience is not limited to researchers working in applied mathematics and includes those in engineering, material sciences, economics, and life sciences.

  9. Maternal cell phone and cordless phone use during pregnancy and behaviour problems in 5-year-old children

    NARCIS (Netherlands)

    Guxens, Monica; van Eijsden, Manon; Vermeulen, Roel; Loomans, Eva; Vrijkotte, Tanja G. M.; Komhout, Hans; van Strien, Rob T.; Huss, Anke

    2013-01-01

    Background A previous study found an association between maternal cell phone use during pregnancy and maternal-reported child behaviour problems at age 7. Together with cell phones, cordless phones represent the main exposure source of radiofrequency-electromagnetic fields to the head. Therefore, we

  10. Data-Intensive Cloud Service Provision for Research Institutes: the Network Connectivity Problem

    CERN Document Server

    Cass, Tony; CERN. Geneva. IT Department

    2016-01-01

    Much effort (and money) has been invested in recent years to ensure that academic and research sites are well interconnected with high-capacity networks that, in most cases, span national and continental boundaries. However, these dedicated research and education networks, whether national (NRENs) or trans-continental (RENs), frequently have Acceptable Use Policies (AUPs) that restrict their use by commercial entities, notably Cloud Service Providers (CSPs). After a brief summary of the issues involved, we describe three approaches to removing the network connectivity barrier that threatens to limit the ability of academic and research institutions to profit effectively from services offered by CSPs.

  11. Design of a Maglev Vibration Test Platform for the Research of Maglev Vehicle-girder Coupled Vibration Problem

    Directory of Open Access Journals (Sweden)

    Zhou Danfeng

    2017-01-01

    Full Text Available The maglev vehicle-girder coupled vibration problem has been encountered in many maglev test or commercial lines, which significantly degrade the performance of the maglev train. In previous research on the principle of the coupled vibration problem, it has been discovered that the fundamental model of the maglev girder can be simplified as a series of mass-spring resonators of different but related resonance frequencies, and that the stability of the vehicle-girder coupled system can be investigated by separately examining the stability of each mass-spring resonator – electromagnet coupled system. Based on this conclusion, a maglev test platform, which includes a single electromagnetic suspension control system, is built for experimental study of the coupled vibration problem. The guideway of the test platform is supported by a number of springs so as to change its flexibility. The mass of the guideway can also be changed by adjusting extra weights attached to it. By changing the flexibility and mass of the guideway, the rules of the maglev vehicle-girder coupled vibration problem are to be examined through experiments, and related theory on the vehicle-girder self-excited vibration proposed in previous research is also testified.

  12. Contextual Uncertainties, Human Mobility, and Perceived Food Environment: The Uncertain Geographic Context Problem in Food Access Research.

    Science.gov (United States)

    Chen, Xiang; Kwan, Mei-Po

    2015-09-01

    We examined the uncertainty of the contextual influences on food access through an analytic framework of the uncertain geographic context problem (UGCoP). We first examined the compounding effects of two kinds of spatiotemporal uncertainties on people's everyday efforts to procure food and then outlined three key dimensions (food access in real time, temporality of the food environment, and perceived nutrition environment) in which research on food access must improve to better represent the contributing environmental influences that operate at the individual level. Guidelines to address the UGCoP in future food access research are provided to account for the multidimensional influences of the food environment on dietary behaviors.

  13. The waste management at research laboratories - problems and solutions; Gestao de rejeitos radioativos em laboratorios de pesquisa - problemas e solucoes

    Energy Technology Data Exchange (ETDEWEB)

    Dellamano, Jose Claudio; Vicente, Roberto, E-mail: jcdellam@ipen.b, E-mail: rvicente@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Gerencia de Rejeitos Radioativos

    2011-10-26

    The radioactive management in radioactive installations must be planned and controlled. However, in the case of research laboratories, that management is compromised due to the common use of materials and installations, the lack of trained personnel and the nonexistence of clear and objective orientations by the regulator organism. Such failures cause an increasing of generated radioactive wastes and the imprecision or nonexistence of record of radioactive substances, occasioning a financial wastage, and the cancelling of licences for use of radioactive substances. This paper discusses and proposes solutions for the problems found at radioactive waste management in research laboratories

  14. RESEARCH ON SOLVING TRAVELLING SALESMAN PROBLEM USING RANK BASED ANT SYSTEM ON GPU

    Directory of Open Access Journals (Sweden)

    Khushbu Khatri

    2015-10-01

    Full Text Available Ant Colony Optimization (ACO is meta-heuristic algorithm inspired from nature to solve many combinatorial optimization problems such as Travelling Salesman Problem (TSP. There are many versions of ACO used to solve TSP like, Ant System, Elitist Ant System, Max-Min Ant System, Rank based Ant System algorithm. For improved performance, these methods can be implemented in parallel architecture like GPU, CUDA architecture. Graphics Processing Unit (GPU provides highly parallel and fully programmable platform. GPUs which have many processing units with an off-chip global memory can be used for general purpose parallel computation. This paper presents a parallel Rank Based Ant System algorithm to solve TSP by use of Pre Roulette Wheel Selection Method.

  15. Research on cultural algorithm for solving routing problem of mobile agent

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The key idea behind cultural algorithm is to explicitly acquire problem-solving knowledge from the evolving population and in return apply that knowledge to guide the search. In this article, cultural algorithm-simulated annealing is proposed to solve the routing problem of mobile agent. The optimal individual is accepted to improve the belief space's evolution of cultural algorithms by simulated annealing. The step size in search is used as situational knowledge to guide the search of optimal solution in the population space. Because of this feature, the search time is reduced. Experimental results show that the algorithm proposed in this article can ensure the quality of optimal solutions, and also has better convergence speed. The operation efficiency of the system is considerably improved.

  16. Time domain analysis for discrete difference equation on discrete linear system controllable problem's research

    Institute of Scientific and Technical Information of China (English)

    DENG Shu-xian; DING Yu; GE Lei

    2008-01-01

    We usually describle a comparatively more complex control system, especially a multi-inputs and multioutputs system by time domation analytical procedure. While the system's controllability means whether the system is controllable according to certain requirements. It involves not only the system's outputs' controllability but also the controllability of the system's partial or total conditions. The movement is described by difference equation in the linear discrete-time system. Therefore, the problem of controllability of the linear discrete-time system has been converted into a problem of the controllability of discrete-time difference equation. The thesis makes out the determination method of the discrete-time system's controllability and puts forward the sufficient and necessary conditions to determine it's controllability by making a study on the controllability of the linear discrete-time equation.

  17. A Research on Structural Characteristics and Problems of Goat Breeding in Nigde

    Directory of Open Access Journals (Sweden)

    Ayhan Ceyhan

    2014-09-01

    Full Text Available This study was carried out to reveal the present status of goat farms in Nigde, to detect basic priority problems and to offer some solutions to these problems. For this purpose, a survey was conducted to the goat breeders face to face in randomly selected total 38 goat farms.The survey questions; goat farms and growing core business activities of enterprises that reveals the overall structure, and also the level of satisfaction with the priority issues of breeders are designed to measure. Analyze the results was shown that a large portion of goat breeders (85.0% were primary school graduates, 5.3%secondery school and also 5.3% high school graduates, goat farms have whole hair goat breed. Goat enterprises have rate of 44.7%, more than 500 goat, 92.1% of goat enterprises go out to highlands, also provided 73.7% of the shepherd's family. In addition, operating revenues were determined come from 50% of goat's milk. Goat breeders were evaluated only 39.5% the form of cheese production, as 60.5% of the cheese, butter, yogurt, and the sale of raw milk of the total milk yield. All business was assessed that owners a profitable goat farming as an occupation and the first five main problems were member alliance, ownership sufficient technical knowledge, serving the technical staff, buck mating and breeding presses, goat shelter, respectively. In addition, it was seen that according to Likert scale, at least the first five issues were satisfied that such as feed, labor, and electricity inputs, product marketing price, sold animals the price, market opportunities related to the sale of manufactured products and finacial supply, respectively. As a result, it could be said that the most important problem for goat enterprises in Nigde province is high production costs and low product prices.

  18. Problem-Solving Teams in Shipbuilding (The National Shipbuilding Research Program)

    Science.gov (United States)

    1986-11-01

    drew up flip charts listing all the consolidated problems in a manner that w$uld allow each Steering Committee member to have his individual rating of... flip chart , while the engineer and the pipe sketcher were affixing blown-up engineering drawings on two easels in front of the classroom. The two men...changing the yard in a small way. Now that everyone was seated and the flip charts in place, the facilitator asked John to introduce himself and his

  19. Using Electron Paramagnetic Resonance Spectroscopy To Facilitate Problem Solving in Pharmaceutical Research and Development.

    Science.gov (United States)

    Mangion, Ian; Liu, Yizhou; Reibarkh, Mikhail; Williamson, R Thomas; Welch, Christopher J

    2016-08-19

    As new chemical methodologies driven by single-electron chemistry emerge, process and analytical chemists must develop approaches to rapidly solve problems in this nontraditional arena. Electron paramagnetic resonance spectroscopy has been long known as a preferred technique for the study of paramagnetic species. However, it is only recently finding application in contemporary pharmaceutical development, both to study reactions and to track the presence of undesired impurities. Several case studies are presented here to illustrate its utility in modern pharmaceutical development efforts.

  20. Countermeasure Research on Problems Impeding Farmers’ Successful Entrepreneurship in Minority Areas

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    By investigating the problem of farmers’ entrepreneurship in Gongcheng Yaozu Autonomous County,lying in Guilin,Guangxi,the thesis expounds the existing problems impacting farmers’ successful entrepreneurship in minority areas as follows:firstly,the musty idea of local cadre is obstacle to farmers’ successful entrepreneurship;secondly,the problems of scattered farmers’ entrepreneurship resources,waste and shortage of resources impact good effect of entrepreneurship;thirdly,farmers lack awareness of characteristics and brand,influencing the market competitiveness of products;fourthly,the existence of smallholder consciousness critically hampers the marketization and internationalization of entrepreneurship accomplishments;fifthly,the government pays no attention to the construction of industrial chain,which makes farmers’ entrepreneurship lack sustainability.Based on these,corresponding countermeasures are put forward to promote farmers’ successful entrepreneurship in minority areas as follows:firstly,we should update local leaders’ ideas and emphasize the positive role of farmers’ successful entrepreneurship in county economic development;secondly,we should integrate local entrepreneurship resources and promote the efficiency of farmers’ entrepreneurship;thirdly,we should foster the consciousness of brand and characteristics and strengthen the market competitiveness of entrepreneurship accomplishments;fourthly,we should strengthen the construction of industrial chain to promote sustainable development of farmers’ entrepreneurship.

  1. Review : Public service motivation—practical problems, scientific evidence and the role of a research community

    OpenAIRE

    Vandenabeele, Wouter|info:eu-repo/dai/nl/323038816; Skelcher, Chris

    2015-01-01

    This review article introduces Public Money & Management's theme papers and articles on public service motivation (PSM). PSM has proven to be a promising road in creating public performance and public value and this theme brings it to an even wider audience, ensuring that policy-makers and those responsible for delivering public services worldwide are aware of the value of PSM research. The article also presents new findings about how best to further PSM research.

  2. Present status of research activities relating global warming problems in Japan (mainly MITI and relating organizations)

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, O.

    1993-12-31

    Japanese government has issued action program so called {open_quotes}Action Program to Arrest Global Warming{close_quotes} for preventing global warming at Oct., 1990. According to the program, CO{sub 2} emission should be stabilized on a per capita basis in the year 2000 and beyond at about same level as in 2000 by introducing several methods such as energy conservation, improvement of energy using efficiency, expanding use of renewable energy and so on. The basic concept, target and methods are summarized. At the same time, MITI published so called {open_quotes}New Earth 21{close_quotes} project which aims remedying the earth environment modified by human activities since industrial innovation began at about 200 years ago in coming 100 years. This plan proposed yearly step of research development of technology for mitigating CO{sub 2} emission. According to the MITI`s plan, 15 institutions belonging to AIST have carrying research for developing technology of reducing emission of CO{sub 2} and other greenhouse gases, with cooperation of other research organizations such as RITE (research Institute of Innovative Technology for Earth) and NEDO (New Energy and Industrial Technology Developing Organization). Time schedule of the research development by The New Earth 21 project is summarized in Table 2. Now, in Japan, many national institutions and universities, research works relating reduction and mitigation of GHG are carried out according to this guideline.

  3. Ethical questions concerning research on human embryos, embryonic stem cells and chimeras.

    Science.gov (United States)

    Bobbert, Monika

    2006-12-01

    Research using human embryos and embryonic stem cells is viewed as important for various reasons. Apart from questions concerning legal regulations, numerous ethical objections are raised pertaining to the use of surplus embryos from reproductive medicine as well as the creation of embryos and stem cells through cloning. In the hopes of avoiding ethical problems, alternatives have been proposed including the extraction of egg cells from "dead" embryos derived from in vitro fertilization procedures, the extraction of pluripotent stem cells from blastocysts, technologies such as "altered nuclear transfer" (ANT) and "oocyte-assisted reprogramming" (ANT-OAR) as well as parthenogenesis. Initial ethical assessments show that certain questions pertaining to such strategies have remained unanswered. Furthermore, with the help of new or more differentiated biotechnological procedures, it is possible to create chimeras and hybrids in which human and non-human cells are combined. Human-animal chimeras, in which gametes or embryonic tissue have been mixed with embryonic or adult stem cells, demonstrate a different "quality" and "degree of penetration" from those produced in previous experiments. Not only does this have consequences regarding questions of patentability, this situation also raises fundamental questions concerning the human being's self image, the concept of person, identity and species and the moral rights and duties that are connected with such concepts. There is a need for legal regulation, on the national as well as the international level.

  4. Sickle cell disease and associated problems: Case study of Homozygous sicklers

    Directory of Open Access Journals (Sweden)

    Jyoti Jhariya

    2016-02-01

    Full Text Available This paper is focused on the problems faced by homozygous individuals of sickle cell disease. In a survey of 500 household of 17 villages of district Mandla, a total of 2316 individuals were covered out of which 13 were found homozygous for the disorder; whereas 3 homozygous children were reported died preceding to one year of the survey. In depth case studies of these children were recorded. The highest age of surviving homozygous individual was 30 years. After 4-5 years of age their survival is very difficult and they require frequent blood transfusion. They face frequent episodes of various infections and unbearable pain. The findings are based on longitudinal and cross sectional study as well as empirical field investigation. It was found that the homozygous children have to face multiple problems, acute pain, priapism, alienation, frequent hospitalization, economic constraints. The families of homozygous children have to face frequent emotional shock as well as economic burden. The problem of homozygous sicklers can be categorized as clinical, educational, economic etc. and is a challenge for achieving the goal of human development. Further to understand the relationship of the prevalence of gene and Human Development, district and state wise gene (HbS frequency were computed. The bivariate correlation analysis between the district wise prevalence of gene and human development index was found positive but insignificant (r2=0.065, p>0.8. At the same time, the correlation of prevalence of the HbS gene and human development index for 11 states was found negative and insignificant (r2=-0.237, p>0.5. It leads to conclude that there is no apparent correlation between the prevalence of gene and the human development in that particular region, although there is lack of sufficient data.

  5. Ceramic Lithium Ion Conductor to Solve the Anode Coking Problem of Practical Solid Oxide Fuel Cells.

    Science.gov (United States)

    Wang, Wei; Wang, Feng; Chen, Yubo; Qu, Jifa; Tadé, Moses O; Shao, Zongping

    2015-09-07

    For practical solid oxide fuel cells (SOFCs) operated on hydrocarbon fuels, the facile coke formation over Ni-based anodes has become a key factor that limits their widespread application. Modification of the anodes with basic elements may effectively improve their coking resistance in the short term; however, the easy loss of basic elements by thermal evaporation at high temperatures is a new emerging problem. Herein, we propose a new design to develop coking-resistant and stable SOFCs using Li(+) -conducting Li0.33 La0.56 TiO3 (LLTO) as an anode component. In the Ni/LLTO composite, any loss of surface lithium can be efficiently compensated by lithium diffused from the LLTO bulk under operation. Therefore, the SOFC with the Ni/LLTO anode catalyst layer yields excellent power outputs and operational stability. Our results suggest that the simple adoption of a Li(+) conductor as a modifier for Ni-based anodes is a practical and easy way to solve the coking problem of SOFCs that operate on hydrocarbons.

  6. A time dependent approach for removing the cell boundary error in elliptic homogenization problems

    Science.gov (United States)

    Arjmand, Doghonay; Runborg, Olof

    2016-06-01

    This paper concerns the cell-boundary error present in multiscale algorithms for elliptic homogenization problems. Typical multiscale methods have two essential components: a macro and a micro model. The micro model is used to upscale parameter values which are missing in the macro model. To solve the micro model, boundary conditions are required on the boundary of the microscopic domain. Imposing a naive boundary condition leads to O (ε / η) error in the computation, where ε is the size of the microscopic variations in the media and η is the size of the micro-domain. The removal of this error in modern multiscale algorithms still remains an important open problem. In this paper, we present a time-dependent approach which is general in terms of dimension. We provide a theorem which shows that we have arbitrarily high order convergence rates in terms of ε / η in the periodic setting. Additionally, we present numerical evidence showing that the method improves the O (ε / η) error to O (ε) in general non-periodic media.

  7. Paid to share: IVF patients, eggs and stem cell research.

    Science.gov (United States)

    Roberts, Celia; Throsby, Karen

    2008-01-01

    Following a recent decision by the human fertilisation and embryology authority (HFEA), British women undergoing in vitro fertilisation (IVF) treatment can be 'paid to share' their eggs with stem cell researchers. The HFEA and the clinic proposing the scheme present this as a 'win-win' arrangement benefiting both infertile women and couples and British science. It is also represented as concurrently both 'business as usual' and an exceptional case. Constituting a significant departure from the previous policy and practice of altruistic donation, the scheme has raised significant concerns among clinicians and activists. Here, we ask what questions feminists can bring to these debates without resorting to a position of either refusal or affirmation. Drawing on diverse materials from public debates, as well as social scientific literature on gamete and embryo donation, we undertake a close analysis of the discursive framing and justification of the proposal. We argue that these discourses are characterised by three linked areas of elision and distinction: treatment and research; eggs and embryos; and donation and selling. Our analysis highlights the need for innovative social, ethical and political consideration of egg sharing for stem cell research.

  8. One cell, one love: a journal for microbial research

    Directory of Open Access Journals (Sweden)

    Didac Carmona-Gutierrez

    2014-01-01

    Full Text Available With their broad utility for biotechnology, their continuous menace as infectious pathogens, and as an integral part of our bodies (intestinal flora, unicellular organisms remain in the focus of global research. This interest has been further stimulated by the challenge to counteract the emergence of multi-resistant microbes, as well as by the recent advances in establishing unicellular organisms as valid models for human diseases. It is our great pleasure to launch the inaugural issue of Microbial Cell (MIC, an international, open-access, peer-reviewed journal dedicated to microbial research. MIC is committed to the publication of articles that deal with the characterization of unicellular organisms (or multicellular microorganisms in their response to internal and external stimuli and/or in the context of human health and disease. Thus, MIC covers heterogeneous topics in diverse areas ranging from microbial and general cell biology to molecular signaling, disease modeling and pathogen targeting. MIC’s Editorial Board counts with world-class leaders in a wide variety of fields, including microbiology, aging, evolution, biotechnology, ecology, biochemistry, infection biology, and human pathophysiology. We are convinced that MIC will appeal to readers from a broad scientific and medical background, including basic researchers, microbiologists, clinicians, educators and – we hope – policy makers as well as to any interested individual.

  9. Research development and demonstration of a fuel cell/battery powered bus system. Interim report, August 1, 1991--April 30, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Romano, S.; Wimmer, R.

    1992-04-30

    This report describes the progress in the Georgetown University research, development and demonstration project of a fuel cell/battery powered bus system. The topics addressed in the report include vehicle design and application analysis, technology transfer activities, coordination and monitoring of system design and integration contractor, application of fuel cells to other vehicles, current problems, work planned, and manpower, cost and schedule reports.

  10. Employment of Questionnaire as Tool for Effective Business Research Outcome: Problems and Challenges

    Directory of Open Access Journals (Sweden)

    ADENIYI AKINGBADE WAIDI

    2016-06-01

    Full Text Available Questionnaire has to do with questions designed to gather information or data for analysis. Questionnaire has to be adequate, simple, focused and related to the subject which the research is set to achieve and to test the hypotheses and questions that are formulated for the study. But many questionnaires are constructed and administered without following proper guideline which hinders there end result. This paper assesses some of the guides for constructing questionnaire as well as it uses and the extent to which it enhanced manager’s access to reliable data and information. Descriptive method is employed for the study. Findings revealed that poor or badly prepared questionnaire produce questionnaire that does not provide effective results. Managers and researchers that use such questionnaire hardly achieve their organisational and research objectives. The need for good, well prepared and adequate questionnaire is exemplified by its being the primary tool for analytical research. The study recommends that questionnaire be properly prepared for effective research outcome.

  11. Way Search to Research: from Academic Exercises in Architecture to Scientific Investigations into Actual Problems

    Directory of Open Access Journals (Sweden)

    Gintaras Stauskis

    2012-05-01

    Full Text Available Abstract. An interest in doctoral studies reflects the overall status of the scientist in the country in general and the role of science in the architect profession in particular. The article analyses the basic channels of how the students of architecture search for and find the ways to transfer themselves from the study area into an academic research environment. In order to figure out general trends and to outline the differences and similarities of doctoral studies that could further facilitate cooperation, the paper presents the thematic outputs of doctoral programmes in architecture schools in Vilnius, Riga, Venice, Jelgava and Weimar. With reference to the example of the Faculty of Architecture, VGTU, the trends towards developing research activities are analysed taking into account three interconnected branches of architecture: urban design, building architecture and landscape architecture. The cooperation and coordination of academic and research activities in wider European space is taking place upon common interest based on the specificities of each school and priorities of the chosen region. The awareness of global and regional processes in architectural research is an important point for the present and coming generations of researchers in Europe as they are building their careers on the basis of investigation into the options of the local applications of global competences in a cross-professional and inter-disciplinary way.

  12. Electrical research on solar cells and photovoltaic materials

    Science.gov (United States)

    Orehotsky, J.

    1985-01-01

    A systematic study of the properties of various polymer pottant materials and of the electrochemical corrosion mechanisms in solar cell materials is required for advancing the technology of terrestrial photovoltaic modules. The items of specific concern in this sponsored research activity involve: (1) kinetics of plasticizer loss in PVB, (2) kinetics of water absorption and desorption in PVB, (3) kinetics of water absorption and desorption in EVA, (4) the electrical properties at PVB as a function of temperature and humidity, (5) the electrical properties of EVA as a function of temperature and humidity, (6) solar cell corrosion characteristics, (7) water absorption effects in PVB and EVA, and (8) ion implantation and radiation effects in PVB and EVA.

  13. Cell manipulation in autologous chondrocyte implantation: from research to cleanroom.

    Science.gov (United States)

    Roseti, Livia; Serra, Marta; Tigani, Domenico; Brognara, Irene; Lopriore, Annamaria; Bassi, Alessandra; Fornasari, Pier Maria

    2008-04-01

    In the field of orthopaedics, autologous chondrocyte implantation is a technique currently used for the regeneration of damaged articular cartilage. There is evidence of the neo-formation of tissue displaying characteristics similar to hyaline cartilage. In vitro chondrocyte manipulation is a crucial phase of this therapeutic treatment consisting of different steps: cell isolation from a cartilage biopsy, expansion in monolayer culture and growth onto a three-dimensional biomaterial to implant in the damaged area. To minimise the risk of in vitro cell contamination, the manipulation must be performed in a controlled environment such as a cleanroom. Moreover, the choice of reagents and raw material suitable for clinical use in humans and the translation of research protocols into standardised production processes are important. In this study we describe the preliminary results obtained by the development of chondrocyte manipulation protocols (isolation and monolayer expansion) in cleanrooms for the application of autologous implantation.

  14. Genome editing in pluripotent stem cells: research and therapeutic applications

    Energy Technology Data Exchange (ETDEWEB)

    Deleidi, Michela, E-mail: michela.deleidi@dzne.de [German Center for Neurodegenerative Diseases (DZNE) Tübingen within the Helmholtz Association, Tübingen (Germany); Hertie Institute for Clinical Brain Research, University of Tübingen (Germany); Yu, Cong [Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, New York (United States)

    2016-05-06

    Recent progress in human pluripotent stem cell (hPSC) and genome editing technologies has opened up new avenues for the investigation of human biology in health and disease as well as the development of therapeutic applications. Gene editing approaches with programmable nucleases have been successfully established in hPSCs and applied to study gene function, develop novel animal models and perform genetic and chemical screens. Several studies now show the successful editing of disease-linked alleles in somatic and patient-derived induced pluripotent stem cells (iPSCs) as well as in animal models. Importantly, initial clinical trials have shown the safety of programmable nucleases for ex vivo somatic gene therapy. In this context, the unlimited proliferation potential and the pluripotent properties of iPSCs may offer advantages for gene targeting approaches. However, many technical and safety issues still need to be addressed before genome-edited iPSCs are translated into the clinical setting. Here, we provide an overview of the available genome editing systems and discuss opportunities and perspectives for their application in basic research and clinical practice, with a particular focus on hPSC based research and gene therapy approaches. Finally, we discuss recent research on human germline genome editing and its social and ethical implications. - Highlights: • Programmable nucleases have proven efficient and specific for genome editing in human pluripotent stem cells (hPSCs). • Genome edited hPSCs can be employed to study gene function in health and disease as well as drug and chemical screens. • Genome edited hPSCs hold great promise for ex vivo gene therapy approaches. • Technical and safety issues should be first addressed to advance the clinical use of gene-edited hPSCs.

  15. Being relevant: Practical guidance for early career researchers interested in solving conservation problems

    Directory of Open Access Journals (Sweden)

    J.M. Chapman

    2015-07-01

    Full Text Available In a human-altered world where biodiversity is in decline and conservation problems abound, there is a dire need to ensure that the next generation of conservation scientists have the knowledge, skills, and training to address these problems. So called “early career researchers” (ECRs in conservation science have many challenges before them and it is clear that the status quo must change to bridge the knowledge–action divide. Here we identify thirteen practical strategies that ECRs can employ to become more relevant. In this context, “relevance” refers to the ability to contribute to solving conservation problems through engagement with practitioners, policy makers, and stakeholders. Conservation and career strategies outlined in this article include the following: thinking ‘big picture’ during conservation projects; embracing various forms of knowledge; maintaining positive relationships with locals familiar with the conservation issue; accepting failure as a viable (and potentially valuable outcome; daring to be creative; embracing citizen science; incorporating interdisciplinarity; promoting and practicing pro-environmental behaviours; understanding financial aspects of conservation; forming collaboration from the onset of a project; accepting the limits of technology; ongoing and effective networking; and finally, maintaining a positive outlook by focusing on and sharing conservation success stories. These strategies move beyond the generic and highlight the importance of continuing to have an open mind throughout the entire conservation process, from establishing one’s self as an asset to embracing collaboration and interdisciplinary work, and striving to push for professional and personal connections that strengthen personal career objectives.

  16. 肿瘤干细胞研究进展%Research advances on cancer stem cells

    Institute of Scientific and Technical Information of China (English)

    毕瑞

    2010-01-01

    利用特异性的细胞表面标记分子已经从各类肿瘤组织中分离到了肿瘤干细胞,包括骨髓瘤、肺癌、结肠癌、前列腺癌和胰腺癌.但存在细胞表面标记分子专属性差以及异种移植问题.从临床应用角度来看,将肿瘤干细胞作为肿瘤治疗的靶点,寻找肿瘤干细胞与肿瘤发生的密切关系,选择性地杀伤肿瘤干细胞,为临床根治肿瘤和防止肿瘤复发与转移提供了新的思路.%Certain specific cancer stem cell subpopulation has been isolated from many kinds of tumors by some specified cell surface maker, including myeloma, lung carcinoma, colon cancer, prostate cancer and pancreatic carcinoma. However, poor individual specificity of cell surface maker molecules and heterograft-related problems provoke more researchers to find more specified cell surface makers and establish humanized mice receptor model in the future. From a clinical perspective, tumor stem cells are considered to be the potential target for curing cancer. Research advances in tumor stem cells can help us to elucidate the close relationship between tumor stem cells and tumorigenesis and provide new ideas and alternative pathways for us to conquer the tumor and avoid tumor recurrence and metastasis.

  17. DIGITAL HUMANISTIC PEDAGOGY: RELEVANT PROBLEMS OF SCIENTIFIC RESEARCH IN THE FIELD OF USING ICT IN EDUCATION

    Directory of Open Access Journals (Sweden)

    Valeriy Yu. Bykov

    2016-07-01

    Full Text Available In the article theoretical and methodological principles of digital humanistic pedagogy – the science about the laws of creating a positive integrated educational reality as a result of the convergence of physical and virtual (created using ICT training spaces (environments are determined. Based on the use of modern ICT learning activity (formal, nonformal and informal is at the intersection of two worlds: the real and the virtual. Methodology and research methods of classical pedagogy require review and improvement in the context of current realities of the educational process, needs and interests of all its subjects. The development of digital humanities in the international educational space is analyzed; the content of the new field of pedagogical knowledge as part of digital humanistic is outlined; research methods and directions of current scientific research are defined.

  18. Research on consumable distribution mode of shipbuilder’s shop based on vehicle routing problem

    Directory of Open Access Journals (Sweden)

    Xiang Su

    2017-02-01

    Full Text Available A distribution vehicle optimization is established with considerations for the problem of long period of requisition and high shop costs due to the existing consumable requisition mode in shipbuilder’s shops for the requirements of shops for consumables. The shortest traveling distance of distribution vehicles are calculated with the genetic algorithm (GA. Explorations are made into a shop consumable distribution mode for shipbuilders to help them to effectively save their production logistics costs, enhance their internal material management level and provide reference for shipbuilder’s change in traditional ways and realization of just-in-time (JIT production.

  19. Does terrorism work? The debates, problems, and a framework for future research

    Directory of Open Access Journals (Sweden)

    Richard English

    2016-04-01

    Full Text Available For both intellectual and practical reasons, the question “Does terrorism work?” is vital. And yet it has largely been eclipsed by other debates within the scholarly literature on terrorism. This article considers some of the recent contributions to the emerging discussion of the question. It then outlines some of the problems inherent in the academic debate that has taken place thus far on the subject, and sketches a framework for making future scholarship in this area more inclusive, systematic and dialogically fruitful than it has been to date.

  20. CONTROL SYSTEM FOR TILTABLE PLATE WITH TWO DEGREES OF FREEDOM FOR RESEARCH OF DYNAMIC MANIPULATION PROBLEMS

    Directory of Open Access Journals (Sweden)

    D. Dobriborsci

    2017-01-01

    Full Text Available The paper presents results of work on control system design for tiltable plate with two degrees of freedom. Designed robotic system includes technical vision system that provides an opportunity to get the position of the control object placed on the square plate. Two servomotors provide each tilting axis operation. Single-board computer transmits angle values and other design elements to the servomotors by USB interface from the workstation. The problem of the object stabilization in the given coordinates on the plate is solved.