WorldWideScience

Sample records for cell research problems

  1. Islamic Education Research Problem

    Directory of Open Access Journals (Sweden)

    Abdul Muthalib

    2012-04-01

    Full Text Available This paper will discuss Islamic educational studies that is reviewing how to find, limit and define problems and problem-solving concepts. The central question of this paper is to describe how to solve the problem in Islamic educational research. A researcher or educator who has the knowledge, expertise, or special interest on education for example is usually having a sensitivity to issues relating to educational research. In the research dimension of religious education, there are three types of problems, namely: Problems foundation, structural problems and operational issues. In doing research in Islamic education someone should understand research problem, limiting and formulating the problem, how to solve the problem, other problem relating to the point of research, and research approach.

  2. Problems of research politics

    International Nuclear Information System (INIS)

    Luest, R.

    1977-01-01

    The development in the FRG is portrayed. Illustrated by a particular example, the problems of basic research and of the scientists are presented looking back, looking at the present, and into the future. (WB) [de

  3. Benefiting from 'evil': an incipient moral problem in human stem cell research.

    Science.gov (United States)

    Green, Ronald M

    2002-11-01

    When does benefiting from others' wrongdoing effectively make one a moral accomplice in their evil deeds? If stem cell research lives up to its therapeutic promise, this question (which has previously cropped up in debates over fetal tissue research or the use of Nazi research data) is likely to become a central one for opponents of embryo destruction. I argue that benefiting from wrongdoing is prima facie morally wrong under any of three conditions: (1) when the wrongdoing is one's agent; (2) when acceptance of benefit directly encourages the repetition of the wrongful deed (even though no agency relationship is involved); and (3) when acceptance of a benefit legitimates a wrongful practice. I conclude by showing that, because of the ways in which most embryonic stem cell lines come into being, people who oppose embryo destruction may use human embryonic stem cells without incurring moral blame.

  4. Research, Research Gap and the Research Problem

    OpenAIRE

    Dissanayake, D.M.N.S.W.

    2013-01-01

    Mainly, due to new scientific inquiries and technological advancements Knowledge becomes obsolete. So it creates a dilemma where the applicability of so called theories and models which we learnt in class can still be applied to solve problems? Thus, the scholars bring the notion of RESEARCH as a definite solution which enriches the existing understanding of a phenomenon. This can be either a theory testing or a theory extension (theory building) approach. In fact, gap identification and form...

  5. State of the art: Multi-fuel reformers for automotive fuel cell applications. Problem identification and research needs

    Energy Technology Data Exchange (ETDEWEB)

    Westerholm, R. [Stockholm Univ. (Sweden). Dept. of Analytical Chemistry; Pettersson, L.J. [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Chemical Engineering and Technology

    1999-12-01

    On an assignment from the Transport and Communications Research Board (KFB) a literature study and a study trip to the USA and Great Britain have been performed. The literature study and the study trip was made during late spring and autumn 1999.The purpose of the project was to collect available information about the chemical composition of the product gas from a multi-fuel reformer for a fuel cell vehicle. It was furthermore to identify problems and research needs. The report recommends directions for future major research efforts. The results of the literature study and the study trip led to the following general conclusions: With the technology available today it does not seem feasible to develop a highly efficient and reliable multi-fuel reformer for automotive applications, i. e. for applications where all types of fuels ranging from natural gas to heavy diesel fuels can be used. The potential for developing a durable and reliable system is considerably higher if dedicated fuel reformers are used.The authors propose that petroleum-derived fuels should be designed for potential use in mobile fuel cell applications. In the present literature survey and the site visit discussions we found that there are relatively low emissions from fuel cell engines compared to internal combustion engines. However, the major research work on reformers/fuel cells have been performed during steady-state operation. Emissions during start-up, shutdown and transient operation are basically unknown and must be investigated in more detail. The conclusions and findings in this report are based on open/available information, such as discussions at site visits, reports, scientific publications and symposium proceedings.

  6. Statistical problems in medical research

    African Journals Online (AJOL)

    STORAGESEVER

    2008-12-29

    Dec 29, 2008 ... medical research, there are some common problems in using statistical methodology which may result ... optimal combination of diagnostic tests for osteoporosis .... randomization used include stratification and minimize-.

  7. No Problem? No Research, Little Learning ... Big Problem!

    Directory of Open Access Journals (Sweden)

    Fernando Ornelas Marques

    2012-06-01

    Full Text Available The motivation to carry out this study stemmed from the generalized perception that nowadays youth lacks the skills for the 21st century. Especially the high-level competences like critical thinking, problem solving and autonomy. Several tools can help to improve these competences (e.g. the SCRATCH programming language, but, as researchers and educators, we are mostly concerned with the skill to recognize problems. What if we do not find problems to solve? What if we do not even feel the need to find or solve problems? The problem is to recognize the problem; the next step is to equate the problem; finally we have to feel the need to solve it. No need? No invention. Recognizing a problem is probably the biggest problem of everyday life, because we are permanently faced with problems (many ill-defined problems, which we need to identify, equate and solve.

  8. Fuel Cell Research

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Peter M. [Brown University

    2014-03-30

    Executive Summary In conjunction with the Brown Energy Initiative, research Projects selected for the fuel cell research grant were selected on the following criteria: They should be fundamental research that has the potential to significantly impact the nation’s energy infrastructure. They should be scientifically exciting and sound. They should synthesize new materials, lead to greater insights, explore new phenomena, or design new devices or processes that are of relevance to solving the energy problems. They involve top-caliper senior scientists with a record of accomplishment, or junior faculty with outstanding promise of achievement. They should promise to yield at least preliminary results within the given funding period, which would warrant further research development. They should fit into the overall mission of the Brown Energy Initiative, and the investigators should contribute as partners to an intellectually stimulating environment focused on energy science. Based on these criteria, fourteen faculty across three disciplines (Chemistry, Physics and Engineering) and the Charles Stark Draper Laboratory were selected to participate in this effort.1 In total, there were 30 people supported, at some level, on these projects. This report highlights the findings and research outcomes of the participating researchers.

  9. Brief report : ethical problems in research practice

    OpenAIRE

    Colnerud, Gunnel

    2013-01-01

    Most accounts of the ethical problems facing researchers across a broad spectrum of research fields come from ethicists, ethics committees, and specialists committed to the study of ethics in human research. In contrast, this study reports on the ethical questions that researchers, themselves, report facing in their everyday practice. Fifty-five Swedish researchers contributed 109 examples of ethical dilemmas, conflicts, and problems in research. They were all researchers at the postdoctoral ...

  10. Computational problems in Arctic Research

    International Nuclear Information System (INIS)

    Petrov, I

    2016-01-01

    This article is to inform about main problems in the area of Arctic shelf seismic prospecting and exploitation of the Northern Sea Route: simulation of the interaction of different ice formations (icebergs, hummocks, and drifting ice floes) with fixed ice-resistant platforms; simulation of the interaction of icebreakers and ice- class vessels with ice formations; modeling of the impact of the ice formations on the underground pipelines; neutralization of damage for fixed and mobile offshore industrial structures from ice formations; calculation of the strength of the ground pipelines; transportation of hydrocarbons by pipeline; the problem of migration of large ice formations; modeling of the formation of ice hummocks on ice-resistant stationary platform; calculation the stability of fixed platforms; calculation dynamic processes in the water and air of the Arctic with the processing of data and its use to predict the dynamics of ice conditions; simulation of the formation of large icebergs, hummocks, large ice platforms; calculation of ridging in the dynamics of sea ice; direct and inverse problems of seismic prospecting in the Arctic; direct and inverse problems of electromagnetic prospecting of the Arctic. All these problems could be solved by up-to-date numerical methods, for example, using grid-characteristic method. (paper)

  11. EARTHQUAKE RESEARCH PROBLEMS OF NUCLEAR POWER GENERATORS

    Energy Technology Data Exchange (ETDEWEB)

    Housner, G. W.; Hudson, D. E.

    1963-10-15

    Earthquake problems associated with the construction of nuclear power generators require a more extensive and a more precise knowledge of earthquake characteristics and the dynamic behavior of structures than was considered necessary for ordinary buildings. Economic considerations indicate the desirability of additional research on the problems of earthquakes and nuclear reactors. The nature of these earthquake-resistant design problems is discussed and programs of research are recommended. (auth)

  12. Operations research problems statements and solutions

    CERN Document Server

    Poler, Raúl; Díaz-Madroñero, Manuel

    2014-01-01

    The objective of this book is to provide a valuable compendium of problems as a reference for undergraduate and graduate students, faculty, researchers and practitioners of operations research and management science. These problems can serve as a basis for the development or study of assignments and exams. Also, they can be useful as a guide for the first stage of the model formulation, i.e. the definition of a problem. The book is divided into 11 chapters that address the following topics: Linear programming, integer programming, non linear programming, network modeling, inventory theory, queue theory, tree decision, game theory, dynamic programming and markov processes. Readers are going to find a considerable number of statements of operations research applications for management decision-making. The solutions of these problems are provided in a concise way although all topics start with a more developed resolution. The proposed problems are based on the research experience of the authors in real-world com...

  13. Problems of scientific research in developing countries

    International Nuclear Information System (INIS)

    Vose, P.B.; Cervellini, A.

    1983-01-01

    The paper gives a general consideration of the problems encountered in the scientific research by the developing countries. Possible optimizations in the long term as well as short term strategies are pointed out

  14. Engaged Problem Formulation in IS Research

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby

    2016-01-01

    “Is this the problem?”: the question that haunts many information systems (IS) researchers when they pursue work relevant to both practice and research. Nevertheless, a deliberate answer to this question requires more than simply asking the involved IS practitioners. Deliberately formulating...

  15. The problem of appraising qualitative research

    OpenAIRE

    Dixon-Woods, M; Shaw, R; Agarwal, S; Smith, J

    2004-01-01

    

 Qualitative research can make a valuable contribution to the study of quality and safety in health care. Sound ways of appraising qualitative research are needed, but currently there are many different proposals with few signs of an emerging consensus. One problem has been the tendency to treat qualitative research as a unified field. We distinguish universal features of quality from those specific to methodology and offer a set of minimally prescriptive prompts to assist with the assessme...

  16. Landmine research: technology solutions looking for problems

    Science.gov (United States)

    Trevelyan, James P.

    2004-09-01

    The global landmine problem came to the attention of researchers in the mid 1990's and by 1997 several advanced and expensive sensor research programs had started. Yet, by the end of 2003, there is little sign of a major advance in the technology available to humanitarian demining programs. Given the motivation and dedication of researchers, public goodwill to support such programs, and substantial research resources devoted to the problem, it is worth asking why these programs do not seem to have had an impact on demining costs or casualty rates. Perhaps there are factors that have been overlooked. This paper reviews several research programs to gain a deeper understanding of the problem. A possible explanation is that researchers have accepted mistaken ideas on the nature of the landmine problems that need to be solved. The paper provides several examples where the realities of minefield conditions are quite different to what researchers have been led to believe. Another explanation may lie in the political and economic realities that drive the worldwide effort to eliminate landmines. Most of the resources devoted to landmine clearance programs come from humanitarian aid budgets: landmine affected countries often contribute only a small proportion because they have different priorities based on realistic risk-based assessment of needs and political views of local people. Some aid projects have been driven by the need to find a market for demining technologies rather than by user needs. Finally, there is a common misperception that costs in less developed countries are intrinsically low, reflecting low rates paid for almost all classes of skilled labour. When actual productivity is taken into account, real costs can be higher than industrialized countries. The costs of implementing technological solutions (even using simple technologies) are often significantly under-estimated. Some political decisions may have discouraged thorough investigation of cost

  17. Advanced Research Workshop on Nonlinear Hyperbolic Problems

    CERN Document Server

    Serre, Denis; Raviart, Pierre-Arnaud

    1987-01-01

    The field of nonlinear hyperbolic problems has been expanding very fast over the past few years, and has applications - actual and potential - in aerodynamics, multifluid flows, combustion, detonics amongst other. The difficulties that arise in application are of theoretical as well as numerical nature. In fact, the papers in this volume of proceedings deal to a greater extent with theoretical problems emerging in the resolution of nonlinear hyperbolic systems than with numerical methods. The volume provides an excellent up-to-date review of the current research trends in this area.

  18. Dye solar cell research

    CSIR Research Space (South Africa)

    Cummings, F

    2009-11-01

    Full Text Available Cummings Energy and Processes Materials Science and Manufacturing Council for Scientific and Industrial Research P.O. Box 395 Pretoria 0001, South Africa 27 November 2009 CONTENT head2rightBackground head2rightCSIR Dye Solar Cell Research head2... rightCollaborations and Links © CSIR 2007 www.csir.co.za head2rightAcknowledgements BACKGROUND head2rightSA is dry: Annual rainfall average of 450 mm compared with a world average of 860 mm head2rightOn upside, we have some...

  19. Hydrogen problems in reactor safety research

    International Nuclear Information System (INIS)

    Casper, H.

    1984-01-01

    The BMFT and BMI have initiated a workshop 'Hydrogen Problems in Reactor Safety Research' that took place October 3./4., 1983. The objective of this workshop was to present the state of the art in the main areas - Hydrogen-Production - Hydrogen-Distribution - Hydrogen-Ignition - Hydrogen-Burning and Containment Behaviour - Mitigation Measures. The lectures on the different areas are compiled. The most important results of the final discussion are summarized as well. (orig.) [de

  20. Cognitive styles: Controversial issues and research problems

    Directory of Open Access Journals (Sweden)

    Natalia N. Volkova

    2016-06-01

    Full Text Available The paper presents an analytical review of cognitive styles research, considering the problems of its theory, methodology, measurement and practical applications. Issues concerning the prospects, as well as theoretical and practical relevance of cognitive styles research, are discussed. We examine the main causes leading to researchers’ declining interest to study of cognitive styles, related to theory, methodology, measurement and practical applications. The main problems discussed relate to lack of clear definition and common theoretical framework. Moreover, the number of empirical studies prevails over the one aimed at theoretical generalization of empirical results and findings, and therefore the primacy of empirics appears. We analyze the possible ways of advancing the field, suggested research programs and potential perspectives for future research. We pose questions of the relationship between cognitive styles and other psychological constructs, such as abilities and cognitive strategies. We emphasize the need to develop integrative models of cognitive styles in order to systematize and organize a large number of existing cognitive styles dimensions. The main controversial issues concerning cognitive styles’ stability and value are considered. We suggest that cognitive style is a psychological mean of cognitive tasks solving, based on both situation circumstances and subject’s current cognitive resources. Issues concerning cognitive styles may answer the question on the nature of individual differences and clarify psychological mechanisms of personality-situation interaction. Furthermore, it may serve as a basis for integrated studies at the areas of personality and cognitive psychology.

  1. Information on Stem Cell Research

    Science.gov (United States)

    ... Home » Current Research » Focus on Research Focus on Stem Cell Research Stem cells possess the unique ability to differentiate into ... virus infection. To search the complete list of stem cell research projects funded by NIH please go to NIH ...

  2. Chemoradiotherapy: successes and problems in translational research

    International Nuclear Information System (INIS)

    Rockwell, S.

    2003-01-01

    The development of mechanistic-based clinical regimens which combine radiation and chemotherapy to improve local control and cure in solid malignancies has proven to be a difficult problem. Studies with human and animal cell lines in culture provide valuable data on the effects and mechanisms of action of radiation and anticancer drugs. They can also suggest mechanisms of interaction between drugs and radiation that might be used to obtain therapeutic gain. Studies with syngeneic rodent tumors or human tumor cell lines xenografted into immune-deficient rodents can be used to test the effects of combined modality regimens on tumors in vivo. Studies of normal tissues in rodents can be used to evaluate potential toxicities. However, at each step in this process of preclinical evaluation there are limitations of the model systems and gaps in the knowledge obtainable from the models. There are also gaps in our understanding of the biology of malignancies in human patients both before treatment and to an even greater extent during protracted therapeutic regimens. Our knowledge of the mechanisms producing dose-limiting injuries in patients is also limited, as is our understanding of the factors which influence the risk to individual patients and the interactions of drug and radiation injury in patients. The limitations of our models and our knowledge generally preclude the direct translation of preclinical findings into rationally designed, effective clinical trials, and can lead to either unexpectedly positive or disappointing results when clinical trials are developed, performed and analyzed. Successes and problems in the translation of preclinical studies of radiation/drug combinations into effective clinical regimens will be discussed and will be illustrated using our laboratory and clinical experience with agents designed to modulate tumor oxygenation and with regimens combining radiation therapy with radiosensitizers or with the mitomycins

  3. Research reactors fuel cycle problems and dilemma

    International Nuclear Information System (INIS)

    Romano, R.

    2004-01-01

    During last 10 years, some problems appeared in different steps of research reactors fuel cycle. Actually the majority of these reactors have been built in the 60s and these reactors were operated during all this long period in a cycle with steps which were dedicated to this activity. Progressively and for reasons often economical, certain steps of the cycle became more and more difficult to manage due to closing of some specialised workshops in the activities of scraps recycling, irradiated fuel reprocessing, even fuel fabrication. Other steps of the cycle meet or will meet difficulties, in particular supplying of fissile raw material LEU or HEU because this material was mostly produced in enrichment units existing mainly for military reason. Rarefaction of fissile material lead to use more and more enriched uraniums said 'of technical quality', that is to say which come from mixing of varied qualities of enriched material, containing products resulting from reprocessing. Actually, problems of end of fuel cycle are increased, either consisting of intermediary storage on the site of reactor or on specialised sites, or consisting of reprocessing. This brief summary shows most difficulties which are met today by a major part of industrials of the fuel cycle in the exercise of their activities

  4. Engaged Problem Formulation in IS Research

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby

    2016-01-01

    problems requires a more substantial engagement with the different stakeholders, especially when their problems are ill structured and situated in complex organizational settings. On this basis, we present an engaged approach to formulating IS problems with, not for, IS practitioners. We have come...

  5. Research Mathematicians' Practices in Selecting Mathematical Problems

    Science.gov (United States)

    Misfeldt, Morten; Johansen, Mikkel Willum

    2015-01-01

    Developing abilities to create, inquire into, qualify, and choose among mathematical problems is an important educational goal. In this paper, we elucidate how mathematicians work with mathematical problems in order to understand this mathematical process. More specifically, we investigate how mathematicians select and pose problems and discuss to…

  6. Research mathematicians’ practices in selecting mathematical problems

    DEFF Research Database (Denmark)

    Misfeldt, Morten; Johansen, Mikkel Willum

    2015-01-01

    mathematicians select and pose problems and discuss to what extent our results can be used to inform, criticize, and develop educational practice at various levels. Selecting and posing problems is far from simple. In fact, it is considered hard, complex, and of crucial importance. A number of criteria...

  7. Problems emerging from practicing research methodologies among ...

    African Journals Online (AJOL)

    The on-going debates and conflicts between defenders of the quantitative research approach and advocates of the qualitative approach to research tends to leave the post graduate students in a dilemma and disillusioned as to which approach to use in their research process. However, the advent of mixed method as the ...

  8. Internet Marketing Research: Opportunities and Problems

    NARCIS (Netherlands)

    Furrer, O.F.G.; Sudharshan, D.

    2001-01-01

    The Internet is promised a brilliant future among the favorite tools of marketing researchers. Develops a typology of Internet marketing surveys showing the existence of eight different designs that can be used by marketers. However, researchers who plan to develop research using the Internet need

  9. THE PROBLEM FIELD OF NEOSHAMANISM CULTURE RESEARCH

    Directory of Open Access Journals (Sweden)

    Ms. Yanina A. Yelinskaya

    2016-09-01

    Full Text Available The article is aimed at considering the problems of cultural studies of neoshamanism and at defining the specificity of this phenomenon. The problem of the content and scope of the concept of «neoshamanism» is focused on; the basic types of neoshamanism are defined. The issues of religious nature of neoshamanism, shamanic ecstasy and the shamanic universe representation are analyzed in the article. The issues of neoshamanism functioning within the framework of contemporary culture and interaction with external cultural institutions are raised.

  10. Chinese Family Problems: Research and Trends.

    Science.gov (United States)

    Zhangling, Wei

    1983-01-01

    Discusses family life in China, which has undergone several dramatic changes including raising of the legal marriage age, less restrictions on divorce, and official promotion of family planning. Because these policies and practices conflict with Chinese traditions, inevitable problems have arisen. (JAC)

  11. Stem cell research: applicability in dentistry.

    Science.gov (United States)

    Mathur, Shivani; Chopra, Rahul; Pandit, I K; Srivastava, Nikhil; Gugnani, Neeraj

    2014-01-01

    In the face of extraordinary advances in the prevention, diagnosis, and treatment of human diseases, the inability of most tissues and organs to repair and regenerate after damage is a problem that needs to be solved. Stem cell research is being pursued in the hope of achieving major medical breakthroughs. Scientists are striving to create therapies that rebuild or replace damaged cells with tissues grown from stem cells that will offer hope to people suffering from various ailments. Regeneration of damaged periodontal tissue, bone, pulp, and dentin is a problem that dentists face today. Stem cells present in dental pulp, periodontal ligament, and alveolar bone marrow have the potential to repair and regenerate teeth and periodontal structures. These stem cells can be harvested from dental pulp, periodontal ligament, and/or alveolar bone marrow; expanded; embedded in an appropriate scaffold; and transplanted back into a defect to regenerate bone and tooth structures. These cells have the potential to regenerate dentin, periodontal ligament, and cementum and can also be used to restore bone defects. The kind of scaffold, the source of cells, the type of in vitro culturing, and the type of surgical procedure to be used all require careful consideration. The endeavor is clearly multidisciplinary in nature, and the practicing dental surgeon has a critical role in it. Playing this role in the most effective way requires awareness of the huge potential associated with the use of stem cells in a clinical setting, as well as a proper understanding of the related problems.

  12. Problems with the disposal of run-out high-activity fission product solution in the Hot Cells of Karlsruhe Nuclear Research Center

    International Nuclear Information System (INIS)

    Schreibmaier, J.

    1979-05-01

    During decanting of 50 l high-level radioactive waste (120 Ci/l) from a transport container about 1 l HAW leaked to the floor of the transfer chamber. The causes for the incident and the removal of the consequences are described. The costs incurred and the losses resulting from the cell facility not having been used are said to amount to 6-8 million DM. Decontamination and repair work took more than 18 months, sometimes more than 80 persons were occupied. The radiation exposure of all persons involved amounted to 80 man-rem. (HP) [de

  13. Methodical Problems in Organic Farming Research

    OpenAIRE

    Schäfer, Winfried

    2002-01-01

    Workshop presentation with particular focus on values, transferability and praxis relevance of organic farming research. Examples from agricultural engineering lead to the conclusion, that prototype farming, goal oriented project management, participative decision making and funding, coaching of co-operation, and coaching of conflict management may enhance long term, holistic and interdisciplinary research.

  14. The Factors Affecting Definition of Research Problems in Educational Technology Researches

    Science.gov (United States)

    Bahçekapili, Ekrem; Bahçekapili, Tugba; Fis Erümit, Semra; Göktas, Yüksel; Sözbilir, Mustafa

    2013-01-01

    Research problems in a scientific research are formed after a certain process. This process starts with defining a research topic and transforms into a specific research problem or hypothesis. The aim of this study was to examine the way educational technology researchers identify their research problems. To this end, sources that educational…

  15. Researching wicked problems in a construction project

    DEFF Research Database (Denmark)

    Jacobsen, Peter Holm

    (Lave, 1988) and critical psychology (Axel, 2002; Dreier, 2008; Højholt & Kousholt, 2011). Situated learning theories have developed some valuable methodologies that can be used to study learning as an aspect of social practices and critical psychology have expanded theories of situated learning...... be elaborated more upon (Pink et. al., 2010). Getting access, formulating strategies for analyses, finding concepts and selecting methods such as participant observations and interviews are often problematic aspects, that influences the knowledge that researchers produces in a number of ways that relates...... to empirical research. I will argue that uncertainty is an important aspect of doing empirical research because the empirical research is a part of a situated learning process and that uncertain situations are a central part of conducting empirical research. I will use an example from my study of the early...

  16. Unveiling Research Agendas: a study of the influences on research problem selection among academic researchers

    Energy Technology Data Exchange (ETDEWEB)

    Bianco, M.; Sutz, J.

    2016-07-01

    Research problem selection is central to the dynamics of scientific knowledge production. Research agendas result from the selection of research problems and the formulation of individual and/or collective academic strategies to address them. But, why researchers study what they study? This paper presents incipient research focused on the way different factors influence the construction of academic research agendas. It takes a researcher-oriented approach relying on opinions and perspectives of a wide range of researchers in all fields of knowledge. The empirical work is carried out in Uruguay, a country in the periphery of mainstream science, whose academic community struggles in search of a balance between the requirements of the world community of scholars and the demands from different national stakeholders. The methodology and research results from this study may be relevant to other countries, at different peripheries. Further, understanding the interplay of influences that shape research agendas is an important tool for policy analysis and planning everywhere. (Author)

  17. Cell Science and Cell Biology Research at MSFC: Summary

    Science.gov (United States)

    2003-01-01

    The common theme of these research programs is that they investigate regulation of gene expression in cells, and ultimately gene expression is controlled by the macromolecular interactions between regulatory proteins and DNA. The NASA Critical Path Roadmap identifies Muscle Alterations and Atrophy and Radiation Effects as Very Serious Risks and Severe Risks, respectively, in long term space flights. The specific problem addressed by Dr. Young's research ("Skeletal Muscle Atrophy and Muscle Cell Signaling") is that skeletal muscle loss in space cannot be prevented by vigorous exercise. Aerobic skeletal muscles (i.e., red muscles) undergo the most extensive atrophy during long-term space flight. Of the many different potential avenues for preventing muscle atrophy, Dr. Young has chosen to study the beta-adrenergic receptor (betaAR) pathway. The reason for this choice is that a family of compounds called betaAR agonists will preferentially cause an increase in muscle mass of aerobic muscles (i.e., red muscle) in animals, potentially providing a specific pharmacological solution to muscle loss in microgravity. In addition, muscle atrophy is a widespread medical problem in neuromuscular diseases, spinal cord injury, lack of exercise, aging, and any disease requiring prolonged bedridden status. Skeletal muscle cells in cell culture are utilized as a model system to study this problem. Dr. Richmond's research ("Radiation & Cancer Biology of Mammary Cells in Culture") is directed toward developing a laboratory model for use in risk assessment of cancer caused by space radiation. This research is unique because a human model will be developed utilizing human mammary cells that are highly susceptible to tumor development. This approach is preferential over using animal cells because of problems in comparing radiation-induced cancers between humans and animals.

  18. Researching older lesbians: problems and partial solutions.

    Science.gov (United States)

    Westwood, Sue

    2013-01-01

    There is a lack of research about older lesbians, who can be considered not only a "hidden population" but also a population in hiding. Yet older lesbians hold vital historical and cultural narratives that are, in turn, the heritage of younger lesbians. They also have much to contribute to understandings about gender, sexuality and aging, and to their currently unmet needs in terms of age-related housing, health, and social care provision. This article reflects on some of the issues that make it difficult to access older lesbians for research purposes. It identifies four problematic areas in researching older lesbians: definitions, access, representative sampling, and ethical issues. It suggests that participative action research might offer a means of widening access and engaging with older lesbians in a more collaborative way.

  19. Bioprinting for stem cell research

    Science.gov (United States)

    Tasoglu, Savas; Demirci, Utkan

    2012-01-01

    Recently, there has been a growing interest to apply bioprinting techniques to stem cell research. Several bioprinting methods have been developed utilizing acoustics, piezoelectricity, and lasers to deposit living cells onto receiving substrates. Using these technologies, spatially defined gradients of immobilized proteins can be engineered to direct stem cell differentiation into multiple subpopulations of different lineages. Stem cells can also be patterned in a high-throughput manner onto flexible implementation patches for tissue regeneration or onto substrates with the goal of accessing encapsulated stem cell of interest for genomic analysis. Here, we review recent achievements with bioprinting technologies in stem cell research, and identify future challenges and potential applications including tissue engineering and regenerative medicine, wound healing, and genomics. PMID:23260439

  20. Vaal River catchment: problems and research needs

    CSIR Research Space (South Africa)

    Braune, E

    1987-01-01

    Full Text Available , the Pretoria-Witwatersrand-Vereeniging (PWV) complex. Although the catchment only produces eight per cent of the mean annual runoff of the country it has the highest concentration of urban, industrial, mining and power generation development in South Africa... of the Vaal River. The purpose of the workshop and preceding symposium was to examine the ever increasing complexity of the Vaal River system, the much enlarged spectrum of user water quality needs and problems, and those activities in the catchment which...

  1. Academic Freedom: Problems in Conceptualization and Research

    Science.gov (United States)

    Abdel Latif, Muhammad M. M.

    2014-01-01

    Academic freedom is of central importance to higher education and it affects all aspects of work at universities. It symbolizes academics' acceptance of the need for openness and flexibility (Balyer, 2011) and it protects the conditions leading to the creation of good teaching and learning, sound research, and scholarship (Atkinson, 2004).…

  2. Problems Portraying Migrants in Applied Linguistics Research

    Science.gov (United States)

    Block, David

    2010-01-01

    This paper is a very personal attempt to explore the problematics of portraying migrants in Applied Linguistics research. I begin with a discussion of identity, in particular what we might mean when we use the term, and from there I go on to explore its fundamental imprecision through an analysis of a census question about ethnicity. I then…

  3. Military Operational Research: the Sensor Coverage Problem

    NARCIS (Netherlands)

    Barros, A.I.; Koopmans, J.

    1999-01-01

    Military Operations Research is a field that has been growing since the Second World War, and in particular in the last decades. Within this vast area, Air Defence, the protection of the air space against an airborne threat, has become a hot topic. ln order to successfully protect a given zone

  4. The Problems of Digestive Diseases in Researches

    Directory of Open Access Journals (Sweden)

    Yu.M. Stepanov

    2013-09-01

    Full Text Available We have carried out an analysis of the 46 theses defended in the subject 14.01.36 «gastroenterology». Of these, 40 % of doctorate theses deals with problems of bowel disease, 40 % — peptic ulcer disease, and 20 % — chronic pancreatitis. In the structure of the thesis for the degree of candidate of sciences 29.5 % defended on the subject of peptic ulcer disease, 22.7 % — intestinal diseases, 18.2 % — gastroesophageal reflux disease, 13.6 % — biliary pathology, 6.8 % — gastritis diseases, and 9.1 % — liver diseases. Most of the theses deals with questions of conservative management of patients with digestive pathology, their rehabilitation, achievement of compliance to therapy. Along with the theses highlighted the issues on pathophysiology of the digestive organs, and the impact of diseases of other organs on the digestive system.

  5. Research program with no ''measurement problem''

    International Nuclear Information System (INIS)

    Noyes, H.P.; Gefwert, C.; Manthey, M.J.

    1985-07-01

    The ''measurement problem'' of contemporary physics is met by recognizing that the physicist participates when constructing and when applying the theory consisting of the formulated formal and measurement criteria (the expressions and rules) providing the necessary conditions which allow him to compute and measure facts, yet retains objectivity by requiring that these criteria, rules and facts be in corroborative equilibrium. We construct the particulate states of quantum physics by a recursive program which incorporates the non-determinism born of communication between asynchronous processes over a shared memory. Their quantum numbers and coupling constants arise from the construction via the unique 4-level combinatorial hierarchy. The construction defines indivisible quantum events with the requisite supraluminal correlations, yet does not allow supraluminal communication. Measurement criteria incorporate c, h-bar, and m/sub p/ or (not ''and'') G. The resulting theory is discrete throughout, contains no infinities, and, as far as we have developed it, is in agreement with quantum mechanical and cosmological fact

  6. ADDRESSING RESEARCH DESIGN PROBLEM IN MIXED METHODS RESEARCH

    OpenAIRE

    Hamed ALAVI; Patrycja HĄBEK

    2016-01-01

    Alongside other disciplines in social sciences, management researchers use mixed methods research more and more in conduct of their scientific investigations. Mixed methods approach can also be used in the field of production engineering. In comparison with traditional quantitative and qualitative research methods, reasons behind increasing popularity of mixed research method in management science can be traced in different factors. First of all, any particular discipline in management can be...

  7. Addressing Research Design Problem in Mixed Methods Research

    Science.gov (United States)

    Alavi, Hamed; Hąbek, Patrycja

    2016-03-01

    Alongside other disciplines in social sciences, management researchers use mixed methods research more and more in conduct of their scientific investigations. Mixed methods approach can also be used in the field of production engineering. In comparison with traditional quantitative and qualitative research methods, reasons behind increasing popularity of mixed research method in management science can be traced in different factors. First of all, any particular discipline in management can be theoretically related to it. Second is that concurrent approach of mixed research method to inductive and deductive research logic provides researchers with opportunity to generate theory and test hypothesis in one study simultaneously. In addition, it provides a better justification for chosen method of investigation and higher validity for obtained answers to research questions. Despite increasing popularity of mixed research methods among management scholars, there is still need for a comprehensive approach to research design typology and process in mixed research method from the perspective of management science. The authors in this paper try to explain fundamental principles of mixed research method, its typology and different steps in its design process.

  8. Problems of information support in scientific research

    Science.gov (United States)

    Shamaev, V. G.; Gorshkov, A. B.

    2015-11-01

    This paper reports on the creation of the open access Akustika portal (AKDATA.RU) designed to provide Russian-language easy-to-read and search information on acoustics and related topics. The absence of a Russian-language publication in foreign databases means that it is effectively lost for much of the scientific community. The portal has three interrelated sections: the Akustika information search system (ISS) (Acoustics), full-text archive of the Akusticheskii Zhurnal (Acoustic Journal), and 'Signal'naya informatsiya' ('Signaling information') on acoustics. The paper presents a description of the Akustika ISS, including its structure, content, interface, and information search capabilities for basic and applied research in diverse areas of science, engineering, biology, medicine, etc. The intended users of the portal are physicists, engineers, and engineering technologists interested in expanding their research activities and seeking to increase their knowledge base. Those studying current trends in the Russian-language contribution to international science may also find the portal useful.

  9. Software problems in magnetic fusion research

    International Nuclear Information System (INIS)

    Gruber, R.

    1982-01-01

    The main world effort in magnetic fusion research involves studying the plasma in a Tokamak device. Four large Tokamaks are under construction (TFTR in USA, JET in Europe, T15 in USSR and JT60 in Japan). To understand the physical phenomena that occur in these costly devices, it is generally necessary to carry out extensive numerical calculations. These computer simulations make use of sophisticated numerical methods and demand high power computers. As a consequence they represent a substantial investment. To reduce software costs, the computer codes are more and more often exhanged among scientists. Standardization (STANDARD FORTRAN, OLYMPUS system) and good documentation (CPC program library) are proposed to make codes exportable. Centralized computing centers would also help in the exchange of codes and ease communication between the staff at different laboratories. (orig.)

  10. Gambling in Taiwan: problems, research and policy.

    Science.gov (United States)

    Yen, Cheng-Fang; Wu, Harry Yi-Jui

    2013-03-01

    This study provides a systematic review of existing research that has evaluated unique gambling experiences in Taiwan. A comprehensive review of electronic databases, including Scopus, PubMed, Chinese Electronic Periodical Services and the Index to Taiwan Periodical Literature System, was conducted to identify evaluations of gambling experiences in Taiwan. Studies that met inclusion criteria were synthesized and assessed. Various types of gambling are prevalent in Taiwan, even though the laws of Taiwan forbid illegal gambling. Both traditional and novel types of gambling have brought adverse impacts to Taiwanese people in multiple aspects of everyday life. The strategies and attitudes of the government towards gambling have been forced to change as gambling has flourished. Various types of gambling have developed in Taiwan in response to social, economic and cultural changes over time. The psychological aspects of gambling, however, need further study to provide fundamental information for developing intervention models for pathological gambling. © 2012 The Authors, Addiction © 2012 Society for the Study of Addiction.

  11. International Society for Stem Cell Research

    Science.gov (United States)

    ... renowned stem cell and regenerative medicine community. More stem cell research Take a closer look Recent Blogs View ... story independent nonprofit organization & the voice of the stem cell research community The International Society for Stem Cell ...

  12. Progress, problems and prospects of porcine pluripotent stem cells

    Directory of Open Access Journals (Sweden)

    Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

    2014-02-01

    Full Text Available Pluripotent stem cells (PSCs, including embryonic stem cells (ESCs and induced PSCs (iPSCs, can differentiate into cells of the three germ layers, suggesting that PSCs have great potential for basic developmental biology research and wide applications for clinical medicine. Genuine ESCs and iPSCs have been derived from mice and rats, but not from livestock such as the pig─an ideal animal model for studying human disease and regenerative medicine due to similarities with human physiologic processes. Efforts to derive porcine ESCs and iPSCs have not yielded high-quality PSCs that can produce chimeras with germline transmission. Thus, exploration of the unique porcine gene regulation network of preimplantation embryonic development may permit optimization of in vitro culture systems for raising porcine PSCs. Here we summarize the recent progress in porcine PSC generation as well as the problems encountered during this progress and we depict prospects for generating porcine naive PSCs.

  13. RUPS: Research Utilizing Problem Solving. Administrators Version. Leader's Manual.

    Science.gov (United States)

    Jung, Charles; And Others

    This manual is to be used by leaders of RUPS (Research Utilizing Problem Solving) workshops for school or district administrators. The workshop's goal is for administrators to develop problem solving skills by using the RUPS simulation situations in a teamwork setting. Although workshop leaders should be familiar with the RUPS materials and…

  14. Esperanto and International Language Problems: A Research Bibliography.

    Science.gov (United States)

    Tonkin, Humphrey R.

    This bibliography is intended both for the researcher and for the occasional student of international language problems, particularly as these relate to the international language Esperanto. The book is divided into two main sections: Part One deals with problems arising from communication across national boundaries and the search for a solution…

  15. Statistical Problems In Medical Research | Okeh | East African ...

    African Journals Online (AJOL)

    Given the main role of a general practitioner as a biostatistician, I thought it would be of interest to enumerate statistical problems in assessing methods of medical diagnosis in general terms. In conducting and reporting of medical research, there are some common problems in using statistical methodology which may result ...

  16. Assessing the Psychosocial Problems In Parenting Sickle-Cell ...

    African Journals Online (AJOL)

    Aim: To assess the psycho social problems encountered in parenting sickle-cell children in Enugu. Method: The subjects include all parents, guardian, foster parents of sickle cell children who have the responsibility of caring for sickle-cell children and who have attended the sickle-cell clinic of the UNTH between June to ...

  17. A Methodological Problem Associated with Researching Women Entrepreneurs

    OpenAIRE

    Beatrice E. Avolio

    2011-01-01

    This article highlights one of the most significant methodological problems of researching women entrepreneurs and understanding the female entrepreneurial experience, which is related to the definition of what is a women entrepreneur. The article outlines the state of research on women entrepreneurs, presents the diverse definitions used in research, conceptualizes the different aspects related to the definition of a woman entrepreneur, and proposes future directions for developing research ...

  18. Recent developments in blood cell labeling research

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, S.C.; Straub, R.F.; Meinken, G.E.

    1988-09-07

    A number of recent developments in research on blood cell labeling techniques are presented. The discussion relates to three specific areas: (1) a new in vitro method for red blood cell labeling with /sup 99m/Tc; (2) a method for labeling leukocytes and platelets with /sup 99m/Tc; and (3) the use of monoclonal antibody technique for platelet labeling. The advantages and the pitfalls of these techniques are examined in the light of available mechanistic information. Problems that remain to be resolved are reviewed. An assessment is made of the progress as well as prospects in blood cell labeling methodology including that using the monoclonal antibody approach. 37 refs., 4 figs.

  19. Recent developments in blood cell labeling research

    International Nuclear Information System (INIS)

    Srivastava, S.C.; Straub, R.F.; Meinken, G.E.

    1988-01-01

    A number of recent developments in research on blood cell labeling techniques are presented. The discussion relates to three specific areas: (1) a new in vitro method for red blood cell labeling with /sup 99m/Tc; (2) a method for labeling leukocytes and platelets with /sup 99m/Tc; and (3) the use of monoclonal antibody technique for platelet labeling. The advantages and the pitfalls of these techniques are examined in the light of available mechanistic information. Problems that remain to be resolved are reviewed. An assessment is made of the progress as well as prospects in blood cell labeling methodology including that using the monoclonal antibody approach. 37 refs., 4 figs

  20. The Problem of Being in Metaphysics | Kanu | African Research ...

    African Journals Online (AJOL)

    What is being? This was and still is one of the fundamental questions within the area of metaphysics. The researcher in this piece studies the dynamics of the problem of being in metaphysics. A historical approach is adopted to this study. The researcher goes through the Ancient, Medieval, Modern and Contemporary ...

  1. A facility for using cluster research to study environmental problems

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This report begins by describing the general application of cluster based research to environmental chemistry and the development of a Cluster Structure and Dynamics Research Facility (CSDRF). Next, four important areas of cluster research are described in more detail, including how they can impact environmental problems. These are: surface-supported clusters, water and contaminant interactions, time-resolved dynamic studies in clusters, and cluster structures and reactions. These facilities and equipment required for each area of research are then presented. The appendices contain workshop agenda and a listing of the researchers who participated in the workshop discussions that led to this report.

  2. A facility for using cluster research to study environmental problems

    International Nuclear Information System (INIS)

    1991-11-01

    This report begins by describing the general application of cluster based research to environmental chemistry and the development of a Cluster Structure and Dynamics Research Facility (CSDRF). Next, four important areas of cluster research are described in more detail, including how they can impact environmental problems. These are: surface-supported clusters, water and contaminant interactions, time-resolved dynamic studies in clusters, and cluster structures and reactions. These facilities and equipment required for each area of research are then presented. The appendices contain workshop agenda and a listing of the researchers who participated in the workshop discussions that led to this report

  3. Fuel Cell Manufacturing Research and Development | Hydrogen and Fuel Cells

    Science.gov (United States)

    | NREL Fuel Cell Manufacturing Research and Development Fuel Cell Manufacturing Research and Development NREL's fuel cell manufacturing R&D focuses on improving quality-inspection practices for high costs. A researcher monitoring web-line equipment in the Manufacturing Laboratory Many fuel cell

  4. Researching consumers' attitudes: Some difficulties, problems and dilemmas

    Directory of Open Access Journals (Sweden)

    Gutić Dragutin

    2010-01-01

    Full Text Available Consumers' attitudes have always had a central place in marketing theory and practice. There is a great number of different problems, difficulties and dilemmas, which come from different sources and have different content, and which very often arise as a stumbling block in researching consumers' attitudes. Part of them is already contained in different views on term attitudes itself. The second part lies in an unsolved puzzle of consumers' attitudes and behaviour relation. The third part is of methodological nature in research. The fourth is in usage of different, numerous techniques that researchers have at their disposal when researching attitudes. It might sound unbelievable, but since the 1960s till today, very few researchers have understood, and knew real nature of the term, essence and meaning of attitudes in marketing. There is even less of them who know how to examine attitudes and generally use adequately and productively. Attitudes belong to the most complex psychical processes. The complexity of attitudes is manifesting during the research. It is not a rarity to become convinced that important contents, such as: determining dimensions, components, sources of emerging and stability of researched attitudes are not present in attitudes' examination and research. In most cases, research results of consumers' attitudes are actually nothing more than statements about the existence of positive and negative attitudes. There is still no complex method that can be used in research. Different, essentially partial methods are being used instead, usually to investigate particular components and dimensions of consumers' attitudes. There are more groups of problems that appear in consumers' attitudes examination. For this occasion, we point out three: problems that result from lack of knowledge and not adequate understanding of attitudes; problems related to level of examinee's (consumer's consciousness of his attitude; problems emerging from

  5. STEM CELL RESEARCH-CONCEPT AND CONTROVERSIES

    African Journals Online (AJOL)

    Dr. E. P. Gharoro

    cells, heart cells, brain cells, etc.). Some researchers regard them as offering the greatest potential for the .... anaemia, heart damage, corneal damage, etc. To be useful for transplant purposes, stem cells must ... activity in the brain was demonstrated contradicting caja's “no new neurons” dogma. However, research into.

  6. RUPS: Research Utilizing Problem Solving. Administrators Version. Participant Materials.

    Science.gov (United States)

    Jung, Charles; And Others

    These materials are the handouts for school administrators participating in RUPS (Research Utilizing Problem Solving) workshops. The purposes of the workshops are to develop skills for improving schools and to increase teamwork skills. The handouts correspond to the 16 subsets that make up the five-day workshop: (1) orientation; (2) identifying…

  7. RUPS: Research Utilizing Problem Solving. Classroom Version. Leader's Manual.

    Science.gov (United States)

    Jung, Charles; And Others

    This training manual is for teachers participating in the Research Utilizing Problem Solving (RUPS) workshops. The workshops last for four and one-half days and are designed to improve the school setting and to increase teamwork skills. The teachers participate in simulation exercises in which they help a fictitious teacher or principal solve a…

  8. APPLICATIONS OF RESEARCH TO THE PROBLEM OF INSTRUCTIONAL FLEXIBILITY.

    Science.gov (United States)

    SARTAIN, HARRY W.

    SELECTED RESEARCH ON THE PROBLEM OF INSTRUCTIONAL FLEXIBILITY IS SURVEYED AND DISCUSSED. BROAD TOPICS OF DISCUSSION ARE DEPARTMENTALIZATION, HOMOGENEOUS SECTIONING, INTERCLASS ABILITY SECTIONING, THE EXTENT OF VARIABILITY IN READING DEVELOPMENT, AND PRACTICES THAT MAY INCREASE FLEXIBILITY. AMONG THOSE PRACTICES TO INCREASE FLEXIBILITY ARE TEAM…

  9. Importance, problems, and reform of agricultural research in Africa ...

    African Journals Online (AJOL)

    Importance, problems, and reform of agricultural research in Africa. ... Sustainable agricultural intensification itself means producing more food and agricultural products from the same overall resources (such as land, labour and water), while reducing the negative environmental impacts and at the same time increasing ...

  10. Radioactive waste disposal in deep geologic deposits. Associated research problems

    International Nuclear Information System (INIS)

    Rousset, G.

    1992-01-01

    This paper describes the research associated problems for radioactive waste disposal in deep geologic deposits such granites, clays or salt deposits. After a brief description of the underground disposal, the author studies the rheology of sedimentary media and proposes rheological models applied to radioactive wastes repositories. Waste-rock interactions, particularly thermal effects and temperature distribution versus time. 17 refs., 14 figs

  11. Enabling Effective Problem-oriented Research for Sustainable Development

    Directory of Open Access Journals (Sweden)

    Christoph Kueffer

    2012-12-01

    Full Text Available Environmental problems caused by human activities are increasing; biodiversity is disappearing at an unprecedented rate, soils are being irreversibly damaged, freshwater is increasingly in short supply, and the climate is changing. To reverse or even to reduce these trends will require a radical transformation in the relationship between humans and the natural environment. Just how this can be achieved within, at most, a few decades is unknown, but it is clear that academia must play a crucial role. Many believe, however, that academic institutions need to become more effective in helping societies move toward sustainability. We first synthesize current thinking about this crisis of research effectiveness. We argue that those involved in producing knowledge to solve societal problems face three particular challenges: the complexity of real-world sustainability problems, maintaining impartiality when expert knowledge is used in decision making, and ensuring the salience of the scientific knowledge for decision makers. We discuss three strategies to meet these challenges: conducting research in interdisciplinary teams, forming research partnerships with actors and experts from outside academia, and framing research questions with the aim of solving specific problems (problem orientation. However, we argue that implementing these strategies within academia will require both cultural and institutional change. We then use concepts from transition management to suggest how academic institutions can make the necessary changes. At the level of system optimization, we call for: quality criteria, career incentives, and funding schemes that reward not only disciplinary excellence but also achievements in inter-/transdisciplinary work; professional services and training through specialized centers that facilitate problem-oriented research and reciprocal knowledge exchange with society; and the integration of sustainability and inter

  12. General problems specific to hot nuclear materials research facilities

    International Nuclear Information System (INIS)

    Bart, G.

    1996-01-01

    During the sixties, governments have installed hot nuclear materials research facilities to characterize highly radioactive materials, to describe their in-pile behaviour, to develop and test new reactor core components, and to provide the industry with radioisotopes. Since then, the attitude towards the nuclear option has drastically changed and resources have become very tight. Within the changed political environment, the national research centres have defined new objectives. Given budgetary constraints, nuclear facilities have to co-operate internationally and to look for third party research assignments. The paper discusses the problems and needs within experimental nuclear research facilities as well as industrial requirements. Special emphasis is on cultural topics (definition of the scope of nuclear research facilities, the search for competitive advantages, and operational requirements), social aspects (overageing of personnel, recruitment, and training of new staff), safety related administrative and technical issues, and research needs for expertise and state of the art analytical infrastructure

  13. Fuel cells: Trends in research and applications

    Science.gov (United States)

    Appleby, A. J.

    Various aspects of fuel cells are discussed. The subjects addressed include: fuel cells for electric power production; phosphoric acid fuel cells; long-term testing of an air-cooled 2.5 kW PAFC stack in Italy; status of fuel cell research and technology in the Netherlands, Bulgaria, PRC, UK, Sweden, India, Japan, and Brazil; fuel cells from the manufacturer's viewpoint; and fuel cells using biomass-derived fuels. Also examined are: solid oxide electrolye fuel cells; aluminum-air batteries with neutral chloride electrolyte; materials research for advanced solid-state fuel cells at the Energy Research Laboratory in Denmark; molten carbonate fuel cells; the impact of the Siemens program; fuel cells at Sorapec; impact of fuel cells on the electric power generation systems in industrial and developing countries; and application of fuel cells to large vehicles.

  14. Spatial extent in demographic research - approach and problems

    Directory of Open Access Journals (Sweden)

    Knežević Aleksandar

    2015-01-01

    Full Text Available One of the starting methodological problems in demographic research is the definition of spatial extent, which mostly doesn’t correspond to spatial extent already defined by different levels of administrative-territorial unitsthat are used for distribution of usable statistical data. That’s why determining the spatial extent of a demographic research is closely tied with administrative-territorial division of the territory that is being researched, wherein the fact that differentiation of demographic phenomena and processes cannot be the only basis of setting the principles of regionalization must be strictly acknowledged. This problem is particularly common in historical demographic analyses of geographically determined wholes, which are in administratively-territorial sense represented by one or more smaller territorial units, with their borders changing through the history, which directly affects comparability of the statistical data, and makes it considerably more difficult to track demographic change through longer time intervals. The result of these efforts is usually a solution based on a compromise which enables us to examine the dynamics of population change with little deviation from already defined borders of regional geographic wholes. For that reason in this paper the problem of defining spatial extent in demographic research is examined trough several different approaches in case of Eastern Serbia, as a geographically determined region, a historic area, a spatially functioning whole and as a statistical unit for demographic research, with no judgment calls in regard to any of the regionalization principles. [Projekat Ministarstva nauke Republike Srbije, br. III 47006

  15. Artificial intelligence and design: Opportunities, research problems and directions

    Science.gov (United States)

    Amarel, Saul

    1990-01-01

    The issues of industrial productivity and economic competitiveness are of major significance in the U.S. at present. By advancing the science of design, and by creating a broad computer-based methodology for automating the design of artifacts and of industrial processes, we can attain dramatic improvements in productivity. It is our thesis that developments in computer science, especially in Artificial Intelligence (AI) and in related areas of advanced computing, provide us with a unique opportunity to push beyond the present level of computer aided automation technology and to attain substantial advances in the understanding and mechanization of design processes. To attain these goals, we need to build on top of the present state of AI, and to accelerate research and development in areas that are especially relevant to design problems of realistic complexity. We propose an approach to the special challenges in this area, which combines 'core work' in AI with the development of systems for handling significant design tasks. We discuss the general nature of design problems, the scientific issues involved in studying them with the help of AI approaches, and the methodological/technical issues that one must face in developing AI systems for handling advanced design tasks. Looking at basic work in AI from the perspective of design automation, we identify a number of research problems that need special attention. These include finding solution methods for handling multiple interacting goals, formation problems, problem decompositions, and redesign problems; choosing representations for design problems with emphasis on the concept of a design record; and developing approaches for the acquisition and structuring of domain knowledge with emphasis on finding useful approximations to domain theories. Progress in handling these research problems will have major impact both on our understanding of design processes and their automation, and also on several fundamental questions

  16. A problem with inclusion in learning disability research.

    Science.gov (United States)

    McClimens, Alex; Allmark, Peter

    2011-09-01

    People with severe learning disability are particularly difficult to include in the research process. As a result, researchers may be tempted to focus on those with learning disability who can be included. The problem is exacerbated in this field as the political agenda of inclusion and involvement is driven by those people with learning disability who are the higher functioning. To overcome this we should first detach the notion of consent from ideas about autonomy and think instead of it as a way to avoid wronging others; this fits the original historical use of consent in research. This allows us to think in terms of including participants to the best of their abilities rather than in terms of a threshold of autonomy. Researchers could then use imaginative ways to include the least able and to ensure they are not wronged in research or by exclusion from it.

  17. Solar Cell Production in Nigeria: Prospects, Options and Problems

    International Nuclear Information System (INIS)

    Fasasi, A. Y.; Siyanbola, W.O.; Ibitoye, F. I.; Pelemo, D. A.

    2002-01-01

    The prospects and problems facing solar cell production in Nigeria are discussed. The paper reviews many proven solar cell materials in terms of their current efficiencies and production costs. Silicon solar cell production appears to be the best technology option for Nigeria because of the abundant quartz sand and waste products from our phosphate fertiliser company that can be employed as starting materials to produce solar grade silicon. Factors affecting solar cell efficiency, choice of solar cell as well as financial and material problems limiting the progress on silicon solar cell production are also discussed. Finally, the paper recommends the simultaneous production of solar grade silicon and coordinated development of the balance of system components as first steps towards actualizing this objective

  18. Students’ Problems in Writing Paraphrases in Research Paper Writing Class

    Directory of Open Access Journals (Sweden)

    Herdiansari Hayuningrum

    2017-01-01

    Full Text Available Paraphrase is one of the techniques of incorporating sources in which every writer is allowed to borrow the author’s ideas and restate them into their own words. Based on the previous study, it was found that English Language Education Study Program (ELESP students, Sanata Dharma University, were unable to paraphrase properly since they tended to copy the author’s words directly. If this problem was continuously ignored, it would be dangerous for the students because they could be charged with inadvertent plagiarism. This study was intended to investigate ELESP students’ problems in writing paraphrases and the reasons why they produce unacceptable paraphrases by conducting document analysis and interview in Research Paper Writing class. From the findings, it could be identified that the most frequent type of problem encountered by the students was word-for-word plagiarism.   DOI: https://doi.org/10.24071/llt.2012.150101

  19. Setting FIRES to Stem Cell Research

    Science.gov (United States)

    Miller, Roxanne Grietz

    2005-01-01

    The goal of this lesson is to present the basic scientific knowledge about stem cells, the promise of stem cell research to medicine, and the ethical considerations and arguments involved. One of the challenges of discussing stem cell research is that the field is constantly evolving and the most current information changes almost daily. Few…

  20. Computer codes for problems of isotope and radiation research

    International Nuclear Information System (INIS)

    Remer, M.

    1986-12-01

    A survey is given of computer codes for problems in isotope and radiation research. Altogether 44 codes are described as titles with abstracts. 17 of them are in the INIS scope and are processed individually. The subjects are indicated in the chapter headings: 1) analysis of tracer experiments, 2) spectrum calculations, 3) calculations of ion and electron trajectories, 4) evaluation of gamma irradiation plants, and 5) general software

  1. The waste management at research laboratories - problems and solutions

    International Nuclear Information System (INIS)

    Dellamano, Jose Claudio; Vicente, Roberto

    2011-01-01

    The radioactive management in radioactive installations must be planned and controlled. However, in the case of research laboratories, that management is compromised due to the common use of materials and installations, the lack of trained personnel and the nonexistence of clear and objective orientations by the regulator organism. Such failures cause an increasing of generated radioactive wastes and the imprecision or nonexistence of record of radioactive substances, occasioning a financial wastage, and the cancelling of licences for use of radioactive substances. This paper discusses and proposes solutions for the problems found at radioactive waste management in research laboratories

  2. Trouble in Paradise: Problems in Academic Research Co-authoring.

    Science.gov (United States)

    Bozeman, Barry; Youtie, Jan

    2016-12-01

    Scholars and policy-makers have expressed concerns about the crediting of coauthors in research publications. Most such problems fall into one of two categories, excluding deserving contributors or including undeserving ones. But our research shows that there is no consensus on "deserving" or on what type of contribution suffices for co-authorship award. Our study uses qualitative data, including interviews with 60 US academic science or engineering researchers in 14 disciplines in a set of geographically distributed research-intensive universities. We also employ data from 161 website posts provided by 93 study participants, again US academic scientists. We examine a variety of factors related to perceived unwarranted exclusion from co-author credit and unwarranted inclusion, providing an empirically-informed conceptual model to explain co-author crediting outcomes. Determinants of outcomes include characteristics of disciplines and fields, institutional work culture, power dynamics and team-specific norms and decision processes.

  3. The problem of creative activity in of social work research

    Directory of Open Access Journals (Sweden)

    Vilka L.

    2012-10-01

    Full Text Available Current Latvian research in the area of social work is not characteristic of a creative and innovative methodological approach. The methodological conservatism derived from general sociology is particularly affecting students in doctoral studies. This proposes a question: should, in the name of scientific novelty, we support research in which the PhD student aims to get rid of his personality behind the shield of authority, sometimes even general sociology textbook truths? Or should we encourage bold challenges to methodological schematism, in which the researcher takes a pose of truly creative research and avoids becoming a representative of scientific marginality lacking one’s personality? The subject of creative activity – the researcher in social work – can best express oneself in the level of philosophic wisdom, identifying only the main guidelines of his creative processes and allowing a large headspace for one’s creative quests. A scientist, also one interested in the problems of social work, can ascertain his/her uniqueness by relying on the concept that any researcher has embarked on an individual journey, circulating on different orbits around one central idea. If the distance between such central idea and the researcher’s activities is increasing, this signifies of either a creatively productive reevaluation of the researcher’s position, or the death of the research process in having lost the original idea. On the other hand, continuous approach towards the central idea either means that the researcher is consistent and determined in his creative research, or there is complete lack of scientific novelty in cases when borrowed foreign ideas are worshipped.

  4. Cell Phones: Current Research Results

    Science.gov (United States)

    ... NAS Report - Identification of Research Needs Relating to Potential Biological or Adverse Health Effects of Wireless Communication Devices World Health Organization: Electromagnetic Fields and Public Health: Mobile Phones International Agency for Research on Cancer Press ...

  5. Guidelines for human embryonic stem cell research

    National Research Council Canada - National Science Library

    Committee on Guidelines for Human Embryonic Stem Cell Research; National Research Council; Board on Health Sciences Policy; Institute of Medicine; Division on Earth and Life Studies; National Research Council

    2005-01-01

    .... Given limited federal involvement, privately funded hES cell research has thus far been carried out under a patchwork of existing regulations, many of which were not designed with this research specifically in mind...

  6. Guidelines for human embryonic stem cell research

    National Research Council Canada - National Science Library

    Committee on Guidelines for Human Embryonic Stem Cell Research, National Research Council

    2005-01-01

    Since 1998, the volume of research being conducted using human embryonic stem (hES) cells has expanded primarily using private funds because of restrictions on the use of federal funds for such research...

  7. Comparative analysis as a basic research orientation: Key methodological problems

    Directory of Open Access Journals (Sweden)

    N P Narbut

    2015-12-01

    Full Text Available To date, the Sociological Laboratory of the Peoples’ Friendship University of Russia has accumulated a vast experience in the field of cross-cultural studies reflected in the publications based on the results of mass surveys conducted in Moscow, Maikop, Beijing, Guangzhou, Prague, Belgrade, and Pristina. However, these publications mainly focus on the comparisons of the empirical data rather than methodological and technical issues, that is why the aim of this article is to identify key problems of the comparative analysis in cross-cultural studies that become evident only if you conduct an empirical research yourself - from the first step of setting the problem and approving it by all the sides (countries involved to the last step of interpreting and comparing the data obtained. The authors are sure that no sociologist would ever doubt the necessity and importance of comparative analysis in the broadest sense of the word, but at the same time very few are ready to discuss its key methodological challenges and prefer to ignore them completely. We summarize problems of the comparative analysis in sociology as follows: (1 applying research techniques to the sample in another country - both in translating and adapting them to different social realities and worldview (in particular, the problematic status of standardization and qualitative approach; (2 choosing “right” respondents to question and relevant cases (cultures to study; (3 designing the research scheme, i.e. justifying the sequence of steps (what should go first - methodology or techniques; (4 accepting the procedures that are correct within one country for cross-cultural work (whether or not that is an appropriate choice.

  8. Problem-centric Process for Research-based Learning

    Directory of Open Access Journals (Sweden)

    Khaled Shaban

    2015-05-01

    Full Text Available Research-based Learning (RbL extends Inquiry and Project-based Learning by facilitating an early stage exposure and training for future scientists through authentic research activities. In this paper, an iterative problem-centric RbL process is introduced, and its activities and management aspects are described. The process helps implement course-integrated research systematically and practically. Furthermore, the novel process follows constructivist methods in incorporating inquiry, scaffolding, open-ended projects, as well as a goal oriented learning approach. The RbL process is adopted in two advanced computing courses, at two different universities: a leading comprehensive Western university and a new university in a developing country. The paper summarizes new lessons learned in these rewarding experiences. In particular, the instructor should help students start their projects, by providing them with previous work or data and pre-approving the papers to review by students. He should also maintain a continuous feedback to and from students to keep the students motivated and help the instructor refine and adapt the RBL process. We note that research collaborators can help students in identifying the research topics early. The paper also shows how to alleviate difficulties that may be encountered by students who find the novel approach demanding, and consequently it also helps the instructors better manage the course contents.

  9. PROBLEMS AND PROSPECTS OF UNIVERSITY DEVELOPMENT: THE SOCIOLOGICAL RESEARCH EXPERIENCE

    Directory of Open Access Journals (Sweden)

    Y. M. Dorozhkin

    2015-03-01

    Full Text Available The paper reveals the sociological research findings reflecting the development problems and prospects of theRussianStateVocationalPedagogicalUniversity. A survey, conducted in March 2013, demonstrates positive dynamics of the university prestige, rank and popularity index compared to the year 2003. The academic staff tends to recognize the unique competitive advantages of the given university: status of the Russian higher school and leading vocational pedagogical institution; professional quality of human resources, variety of prestigious specializations, existence of the Educational Methodology Association, Dissertation Board, etc. Although the respondents point out some factors adversely affecting the university image and public opinion, the criticism helps to identify the problematic units and corresponding contradictions of the university development. The research outcomes can provide the background for strategic development programs ofRussianStateVocationalPedagogicalUniversityfor the nearest future; and help to promote the university brand as the leading, dynamic and competitive educational centre at the regional, federal and international levels.

  10. PROBLEMS AND PROSPECTS OF UNIVERSITY DEVELOPMENT: THE SOCIOLOGICAL RESEARCH EXPERIENCE

    Directory of Open Access Journals (Sweden)

    Y. M. Dorozhkin

    2014-01-01

    Full Text Available The paper reveals the sociological research findings reflecting the development problems and prospects of theRussianStateVocationalPedagogicalUniversity. A survey, conducted in March 2013, demonstrates positive dynamics of the university prestige, rank and popularity index compared to the year 2003. The academic staff tends to recognize the unique competitive advantages of the given university: status of the Russian higher school and leading vocational pedagogical institution; professional quality of human resources, variety of prestigious specializations, existence of the Educational Methodology Association, Dissertation Board, etc. Although the respondents point out some factors adversely affecting the university image and public opinion, the criticism helps to identify the problematic units and corresponding contradictions of the university development. The research outcomes can provide the background for strategic development programs ofRussianStateVocationalPedagogicalUniversityfor the nearest future; and help to promote the university brand as the leading, dynamic and competitive educational centre at the regional, federal and international levels.

  11. Gathering Stones: The Problems of Modern Cultural and Activity Research

    Directory of Open Access Journals (Sweden)

    Reed M.,

    2017-08-01

    Full Text Available Cultural-Historical Psychology 2017. Vol. 13, no. 1, 4–22 doi:10.17759/chp.2017130101 ISSN: 1816-5435 / 2224-8935 (online Gathering Stones: The Problems of Modern Cultural and Activity Research 28 Reed M., Ph.D., Senior Lecturer in Education, University of Bristol, Graduate School of Education, Bristol, Great Britain , Malcolm.Reed@bristol.ac.uk Download PDF-fulltext (306 kbFull Text in Russian (PDF, 306 kbPrintRUIn Russian Abstract This paper explores the verbal image of ‘gathering stones’ in order to appreciate the continuing relevance of Vygotsky to the tradition of inquiry that has been inspired by his example and his work. It considers how our tradition is built on the ancient and critical activity of problematization. The meaning and inner value of tradition is explored in relation to problems we address now and have addressed historically, in particular in relation to the problem of an ascendant version of enculturation. The argument ends with a reflection on the difficulties we still face in addressing educational needs.

  12. THE CONSTRUCTION OF THE RESEARCH PROBLEM AND ITS DISCUSSION

    Directory of Open Access Journals (Sweden)

    Eva Pasek de Pinto

    2008-04-01

    Full Text Available Language has different functions. One of them, the communication, is fundamental for the investigation, because the textualization of its process and results is the base of the diffusion of the advance and increase of the scientific knowledge. However, most students - and those who are not already so - present difficulties in using references, in breaks in cohesion, or in logical and argumentative coherence. Such difficulties limit the generation of texts, as they constitute an obstacle to translate written ideas into an argumentative discourse, typical of science and research. The latter requires the argued presentation of an idea, whose perception, description and obvious reasons make up the problem that is wanted to know, to explain, to verify, to understand or to interpret. Therefore, this short space / time has the purpose of reflecting on the discursive construction of the problem of an inquiry. Its importance lies precisely in the disadvantages of its configuration. In this sense, the reflection is developed from a vision of language and communication; The argumentative discourse and the types of reasoning involved in order to fulfill certain guidelines that underlie the construction of the problem of inquiry and its approach in terms of a positivist-quantitative and / or qualitative study.

  13. Cell culture techniques in honey bee research

    Science.gov (United States)

    Cell culture techniques are indispensable in most if not all life science disciplines to date. Wherever cell culture models are lacking scientific development is hampered. Unfortunately this has been and still is the case in honey bee research because permanent honey bee cell lines have not yet been...

  14. Antecedents of cell aging research.

    Science.gov (United States)

    Hayflick, L

    1989-01-01

    Our observation that normal human and animal cells have a limited capacity to divide and function in vitro overturned a dogma held since the turn of the century. The dogma held that cultured normal cells are immortal and gerontologists interpreted this to mean that aging, therefore, could not be the result of intracellular events. We concluded that longevity and aging do result from intracellular events, and, in the subsequent 30 years, the validity of our finding has been widely confirmed. Other major findings have been made: (a) The number of population doublings and functional events that a cultured normal cell can undergo is inversely proportional to donor age and, probably, directly proportional to species longevity; (b) the limit on cell division and function also occurs in vivo when normal cells are transplanted seriatim; (c) as cell doublings or functional events reach their limit, changes occur in hundreds of variables from the molecular to the whole cell. Most importantly, many of these changes are identical to those seen in intact humans and animals as they age; (d) WI-38, the first widely distributed normal human cell strain has retained its memory of population doubling level during 27 years of cryogenic storage. This is the longest time that any normal human cell has ever been preserved. Evidence that longevity is determined by genetic events is overwhelming but evidence that age changes are the result of gene expression is not. Normal age changes must be distinguished from disease. Because few feral animals ever become old, natural selection could not have favored the development of a genetically programmed aging process. In the 2 or 3 million years of human existence, too few old humans existed to have provided a selective advantage favoring the development of a genetic program that would determine age changes. The selective advantage of maintaining physiological vigor for as long as possible in order to insure maximum reproductive success may be

  15. Mixed isogeometric finite cell methods for the stokes problem

    NARCIS (Netherlands)

    Hoang, T.; Verhoosel, C.V.; Auricchio, F.; van Brummelen, E.H.; Reali, A.

    2017-01-01

    We study the application of the Isogeometric Finite Cell Method (IGA-FCM) to mixed formulations in the context of the Stokes problem. We investigate the performance of the IGA-FCM when utilizing some isogeometric mixed finite elements, namely: Taylor-Hood, Sub-grid, Raviart-Thomas, and Nédélec

  16. A new formulation for the problem of fuel cell homogenization

    International Nuclear Information System (INIS)

    Chao, Y.-A.; Martinez, A.S.

    1982-01-01

    A new homogenization method for reactor cells is described. This new method consists in eliminating the NR approximation for the fuel resonance and the Wigner approximation for the resonance escape probability; the background cross section is then redefined and the problem studied is reanalyzed. (E.G.) [pt

  17. Cyclic flow shop scheduling problem with two-machine cells

    Directory of Open Access Journals (Sweden)

    Bożejko Wojciech

    2017-06-01

    Full Text Available In the paper a variant of cyclic production with setups and two-machine cell is considered. One of the stages of the problem solving consists of assigning each operation to the machine on which it will be carried out. The total number of such assignments is exponential. We propose a polynomial time algorithm finding the optimal operations to machines assignment.

  18. Trends and problems in marital and family therapy research: Possible use of action research

    Directory of Open Access Journals (Sweden)

    Robert Cvetek

    2006-03-01

    Full Text Available Although research in marital and family therapy (MFT is becoming increasingly important, it continues to encounter several major problems. Studies have shown that research has very little influence on the practice of the majority of MFT practitioners. Practitioners see research as unrelated to their concerns. The practice of the majority of MFT practitioners is very individualized, as are the clinical problems and circumstances. Some have therefore started to emphasize the transferability of results instead of generalizability, and studying the practitioner's own practice instead of general concepts. Action research in the field of psychotherapy, as well as in the field of MFT, has been mainly overlooked as a potential method for solving these problems in MFT research. The paper addresses one of many possible ways to use the repeating cycles of the four basic steps in action research (observing and gathering information, reflecting, planning, and acting. The use of these four steps in action research enables therapists to study and improve their own practice in a more systematic, structured, and valid manner. This kind of research connects research and therapy. It is very individualized and oriented towards actions that create therapeutic changes.

  19. Ethical Issues in Stem Cell Research

    OpenAIRE

    Lo, Bernard; Parham, Lindsay

    2009-01-01

    Stem cell research offers great promise for understanding basic mechanisms of human development and differentiation, as well as the hope for new treatments for diseases such as diabetes, spinal cord injury, Parkinson’s disease, and myocardial infarction. However, human stem cell (hSC) research also raises sharp ethical and political controversies. The derivation of pluripotent stem cell lines from oocytes and embryos is fraught with disputes about the onset of human personhood. The reprogramm...

  20. Observation and inverse problems in coupled cell networks

    International Nuclear Information System (INIS)

    Joly, Romain

    2012-01-01

    A coupled cell network is a model for many situations such as food webs in ecosystems, cellular metabolism and economic networks. It consists in a directed graph G, each node (or cell) representing an agent of the network and each directed arrow representing which agent acts on which. It yields a system of differential equations .x(t)=f(x(t)), where the component i of f depends only on the cells x j (t) for which the arrow j → i exists in G. In this paper, we investigate the observation problems in coupled cell networks: can one deduce the behaviour of the whole network (oscillations, stabilization, etc) by observing only one of the cells? We show that the natural observation properties hold for almost all the interactions f

  1. Challenges in Education Research in Taiwan: Research Institutes and Organizations, Research Policies, and Problems

    Directory of Open Access Journals (Sweden)

    Jia Li Huang

    2017-02-01

    Full Text Available Since the 1990s, many education researchers and policy makers worldwide have reviewed education research to attempt to provide strategies to improve the quality of such research in their countries. Taiwan’s government has launched policies and funded support to set the benchmark for Taiwan’s leading universities in international academic competition. The external environment of global competition based on research policy influences the ecosystem of social science research production. To assure the quality of education policy, peer review from within the education community is one approach to supplementing the government’s governance, including the establishment of research institutes, promotion, rewards, and research value. This study tracked the mode of academic research and provides an overview of the status of academic education research in Taiwan. Because education research is part of the humanities and social sciences fields, this study identified the challenges in educational research by examining the trend of social science research and by analyzing research organizations, policy, and the evaluation of research performance. Due to the environment of education research in Taiwan is not friendly to education researcher to accumulate papers in SSCI or international journal, additional concerns entail how education research communities can develop and agree on its quality.

  2. Microfluidic cell culture systems for drug research.

    Science.gov (United States)

    Wu, Min-Hsien; Huang, Song-Bin; Lee, Gwo-Bin

    2010-04-21

    In pharmaceutical research, an adequate cell-based assay scheme to efficiently screen and to validate potential drug candidates in the initial stage of drug discovery is crucial. In order to better predict the clinical response to drug compounds, a cell culture model that is faithful to in vivo behavior is required. With the recent advances in microfluidic technology, the utilization of a microfluidic-based cell culture has several advantages, making it a promising alternative to the conventional cell culture methods. This review starts with a comprehensive discussion on the general process for drug discovery and development, the role of cell culture in drug research, and the characteristics of the cell culture formats commonly used in current microfluidic-based, cell-culture practices. Due to the significant differences in several physical phenomena between microscale and macroscale devices, microfluidic technology provides unique functionality, which is not previously possible by using traditional techniques. In a subsequent section, the niches for using microfluidic-based cell culture systems for drug research are discussed. Moreover, some critical issues such as cell immobilization, medium pumping or gradient generation in microfluidic-based, cell-culture systems are also reviewed. Finally, some practical applications of microfluidic-based, cell-culture systems in drug research particularly those pertaining to drug toxicity testing and those with a high-throughput capability are highlighted.

  3. Cell heterogeneity problems in the analysis of zero power experiments

    International Nuclear Information System (INIS)

    Grimstone, M.J.; Stevenson, J.M.

    1979-01-01

    Methods are described for treating plate and pin cell heterogeneity in the preparation of broad group cross-sections used in the analysis of zero power fast reactor experiments. Methods used at Karlsruhe and Winfrith are summarised and compared, with particular reference to the treatment of resonance shielding, the calculation of broad group spatial fine structure, the treatment of leakage and the calculation of anisotropic diffusion coefficients. The problems of cells near boundaries such as core-breeder interfaces and of singularities such as control rods are also considered briefly. Numerical studies carried out to investigate approximations in the methods are described. These include tests of the accuracy of one-dimensional cell modelling techniques, and the validation by Monte Carlo of methods for treating streaming in the calculation of diffusion coefficients. Comparisons are shown between the heterogeneity effects calculated by the Karlsruhe and Winfrith methods for typical pin and plate cells used in the BIZET experimental programme, and their effect in a whole reactor calculation is indicated. Comparisons are given with measurements which provide tests of the heterogeneity calculations. These include reaction rate scans within pin and plate cells, and reaction rate measurements across sectors of pin and plate fuel, where the flux tilt is determined by the relative reactivity of the pin and plate cells. Finally, the heterogeneity problems arising in the interpretation of reaction rate measurements are discussed. (author)

  4. Fake news portrayals of stem cells and stem cell research.

    Science.gov (United States)

    Marcon, Alessandro R; Murdoch, Blake; Caulfield, Timothy

    2017-10-01

    This study examines how stem cells and stem cell research are portrayed on websites deemed to be purveyors of distorted and dubious information. Content analysis was conducted on 224 articles from 2015 to 2016, compiled by searching with the keywords 'stem cell(s)' on a list of websites flagged for containing either 'fake' or 'junk science' news. Articles contained various exaggerated positive and negative claims about stem cells and stem cell science, health and science related conspiracy theories, and statements promoting fear and mistrust of conventional medicine. Findings demonstrate the existence of organized misinformation networks, which may lead the public away from accurate information and facilitate a polarization of public discourse.

  5. solving the cell formation problem in group technology

    Directory of Open Access Journals (Sweden)

    Prafulla Joglekar

    2001-01-01

    Full Text Available Over the last three decades, numerous algorithms have been proposed to solve the work-cell formation problem. For practicing manufacturing managers it would be nice to know as to which algorithm would be most effective and efficient for their specific situation. While several studies have attempted to fulfill this need, most have not resulted in any definitive recommendations and a better methodology of evaluation of cell formation algorithms is urgently needed. Prima facie, the methodology underlying Miltenburg and Zhang's (M&Z (1991 evaluation of nine well-known cell formation algorithms seems very promising. The primary performance measure proposed by M&Z effectively captures the objectives of a good solution to a cell formation problem and is worthy of use in future studies. Unfortunately, a critical review of M&Z's methodology also reveals certain important flaws in M&Z's methodology. For example, M&Z may not have duplicated each algorithm precisely as the developer(s of that algorithm intended. Second, M&Z's misrepresent Chandrasekharan and Rajagopalan's [C&R's] (1986 grouping efficiency measure. Third, M&Z's secondary performance measures lead them to unnecessarily ambivalent results. Fourth, several of M&Z's empirical conclusions can be theoretically deduced. It is hoped that future evaluations of cell formation algorithms will benefit from both the strengths and weaknesses of M&Z's work.

  6. Advanced research on separating prostate cancer stem cells

    International Nuclear Information System (INIS)

    Hao Yumei; He Xin; Song Naling

    2013-01-01

    Prostate cancer is a common malignant tumor in male urinary system,and may easily develop into the hormone refractory prostate cancer which can hardly be cured. Recent studies had found that the prostate cancer stem cells may be the source of the prostate cancer's occurrence,development, metastasis and recurrence. The therapy targeting the prostate cancer stem cells may be the effective way to cure prostate cancer. But these cells is too low to be detected. The difficulty lies in the low separation efficiency of prostate cancer stem cell, so the effectively separating prostate cancer stem cells occupied the main position for the more in-depth research of prostate cancer stem cells. This paper reviews the research progress and existing problems on the several main separating methods of prostate cancer stem cells, includes the fluorescence activated cells sorting and magnetic activated cells sorting based on prostate cancer stem cell surface markers, the side-population sorting and serum-free medium sphere forming sorting based on prostate cancer stem cell's biology. (authors)

  7. Research Problems in Data Curation: Outcomes from the Data Curation Education in Research Centers Program

    Science.gov (United States)

    Palmer, C. L.; Mayernik, M. S.; Weber, N.; Baker, K. S.; Kelly, K.; Marlino, M. R.; Thompson, C. A.

    2013-12-01

    The need for data curation is being recognized in numerous institutional settings as national research funding agencies extend data archiving mandates to cover more types of research grants. Data curation, however, is not only a practical challenge. It presents many conceptual and theoretical challenges that must be investigated to design appropriate technical systems, social practices and institutions, policies, and services. This presentation reports on outcomes from an investigation of research problems in data curation conducted as part of the Data Curation Education in Research Centers (DCERC) program. DCERC is developing a new model for educating data professionals to contribute to scientific research. The program is organized around foundational courses and field experiences in research and data centers for both master's and doctoral students. The initiative is led by the Graduate School of Library and Information Science at the University of Illinois at Urbana-Champaign, in collaboration with the School of Information Sciences at the University of Tennessee, and library and data professionals at the National Center for Atmospheric Research (NCAR). At the doctoral level DCERC is educating future faculty and researchers in data curation and establishing a research agenda to advance the field. The doctoral seminar, Research Problems in Data Curation, was developed and taught in 2012 by the DCERC principal investigator and two doctoral fellows at the University of Illinois. It was designed to define the problem space of data curation, examine relevant concepts and theories related to both technical and social perspectives, and articulate research questions that are either unexplored or under theorized in the current literature. There was a particular emphasis on the Earth and environmental sciences, with guest speakers brought in from NCAR, National Snow and Ice Data Center (NSIDC), and Rensselaer Polytechnic Institute. Through the assignments, students

  8. Development of the Contiguous-cells Transportation Problem

    Directory of Open Access Journals (Sweden)

    O. E. Charles-Owaba

    2015-08-01

    Full Text Available The issue of scheduling a long string of multi-period activities which have to be completed without interruption has always been an industrial challenge. The existing production/maintenance scheduling algorithms can only handle situations where activities can be split into two or more sets of activities carried out in non-contiguous sets of work periods. This study proposes a contiguous-periods production/maintenance scheduling approach using the Transportation Model. Relevant variables and parameters of contiguous-cells scheduling problem were taken from the literature. A scheduling optimization problem was defined and solved using a contiguous-cells transportation algorithm (CCTA which was applied in order to determine the optimal maintenance schedule of a fleet of ships at a dockyard in South-Western Nigeria. Fifteen different problems were solved. It is concluded that the contiguous-cells transportation approach to production/ maintenance scheduling is feasible. The model will be a useful decision support tool for scheduling maintenance operations.

  9. Fuel cell research: Towards efficient energy

    CSIR Research Space (South Africa)

    Rohwer, MB

    2008-11-01

    Full Text Available fuel cells by optimising the loading of catalyst (being expensive noble metals) and ionomer; 2) Improving conventional acidic direct alcohol fuel cells by developing more efficient catalysts and by investigating other fuels than methanol; 3... these components add significantly to the overall cost of a PEMFC. 1 We focused our research activities on: 1) The effect of the loading of catalytic ink on cell performance; 2) The effect of the ionomer content in the catalytic ink; 3) Testing...

  10. Stem Cell Research and Health Education

    Science.gov (United States)

    Eve, David J.; Marty, Phillip J.; McDermott, Robert J.; Klasko, Stephen K.; Sanberg, Paul R.

    2008-01-01

    Stem cells are being touted as the greatest discovery for the potential treatment of a myriad of diseases in the new millennium, but there is still much research to be done before it will be known whether they can live up to this description. There is also an ethical debate over the production of one of the most valuable types of stem cell: the…

  11. Aviation safety and operation problems research and technology

    Science.gov (United States)

    Enders, J. H.; Strickle, J. W.

    1977-01-01

    Aircraft operating problems are described for aviation safety. It is shown that as aircraft technology improves, the knowledge and understanding of operating problems must also improve for economics, reliability and safety.

  12. The use of human cells in biomedical research and testing.

    Science.gov (United States)

    Combes, Robert D

    2004-06-01

    The ability to use human cells in biomedical research and testing has the obvious advantage over the use of laboratory animals that the need for species extrapolation is obviated, due to the presence of more-relevant morphological, physiological and biochemical properties, including receptors. Moreover, human cells exhibit the same advantages as animal cells in culture in that different cell types can be used, from different tissues, with a wide range of techniques, to investigate a wide variety of biological phenomena in tissue culture. Human cells can also be grown as organotypic cultures to facilitate the extrapolation from cells to whole organisms. Human cell lines have been available for many years on an ad hoc basis from individual researchers, and also from recognised sources, such as the European Collection of Animal Cell Cultures (ECACC) and, in the USA, the Human Cell Culture Centre (HCCC). Such cells have usually been derived from tumours and this has restricted the variety of types of cells available. This problem has been addressed by using primary human cells that can be obtained from a variety of sources, such as cadavers, diseased tissue, skin strips, peripheral blood, buccal cavity smears, hair follicles and surgical waste from biopsy material that is unsuitable for transplantation purposes. However, primary human cells need to be obtained, processed, distributed and handled in a safe and ethical manner. They also have to be made available at the correct time to researchers very shortly after they become available. It is only comparatively recently that the safe and controlled acquisition of surgical waste and non-transplantable human tissues has become feasible with the establishment of several human tissue banks. Recently, the formation of a UK and European centralised network for human tissue supply has been initiated. The problems of short longevity and loss of specialisation in culture are being approached by: a) cell immortalisation to

  13. Researching and Working for Transgender Youth: Contexts, Problems and Solutions

    Directory of Open Access Journals (Sweden)

    Tiffany Jones

    2016-08-01

    Full Text Available In May 2016, two events epitomized the complexities of working for global transgender youth rights. First, United Nations Educational Scientific and Cultural Organisation (UNESCO hosted a ministerial event in which education ministers from around the world released a call to action for protection of students on the basis of their gender identity and expression in schools. Second, the United Nations (UN hosted an event celebrating the family, attended by conservative ministers and activists who mobilized family protectionist discourse against transgender students. This article contemplates, in light of transgender activist Raewyn Connell’s Southern Theory contributions, the complexity of global research and work for transgender youth. It considers key informant interviews with 50 stakeholders in the global push for transgender student rights in education, including members of government and non-government organisations, and academics from Northern and Southern countries. Problems in aiding transgender youth at the global level included safety concerns, the impacts of conservative advocates and media backlash (within family and national protectionist discourses, cultural complexities hampering engagement and translation, dissemination hindrances pertaining to established publishing biases, and financial and collaboration barriers. Solutions including virtual work; multi-level leadership; alliance-building; representation; visibility of transgender youth citizenship and family membership; and legal, financial and capacity-building aid are considered.

  14. Genesis of scientific research of legal problems of reserves

    Directory of Open Access Journals (Sweden)

    Олександр Олександрович Пономаренко

    2017-12-01

    Full Text Available The problems of the legal status of nature reserves as objects of ecological and legal commandment are considered. One of the main directions of the modern strategy of Ukraine’s environmental policy should be the implementation of international standards in the organization and protection of nature reserves as objects of the state natural reserve fund, the improvement of legislation on the nature reserve fund in accordance with the recommendations of the Pan-European Biological and Landscape Diversity Strategy (1995 on the formation of the Pan-European Ecological Network as a single spatial system of territories of European countries with the EU or partially altered landscape. All this allowed to formulate the definition of a natural reserve as a state research institution with the status of a legal entity of national importance and performs the functions of preserving in a natural state typical or unique for the given landscape zone of natural complexes with all components of their components, the study of natural processes and phenomena, the developments in them, the development of scientific principles of environmental protection, the effective use of natural resources and environmental safety, the implementation of ecological education and education of the population in the conditions of full restriction of economic activity not connected with its functioning.

  15. Applications of systems thinking and soft operations research in managing complexity from problem framing to problem solving

    CERN Document Server

    2016-01-01

    This book captures current trends and developments in the field of systems thinking and soft operations research which can be applied to solve today's problems of dynamic complexity and interdependency. Such ‘wicked problems’ and messes are seemingly intractable problems characterized as value-laden, ambiguous, and unstable, that resist being tamed by classical problem solving. Actions and interventions associated with this complex problem space can have highly unpredictable and unintended consequences. Examples of such complex problems include health care reform, global climate change, transnational serious and organized crime, terrorism, homeland security, human security, disaster management, and humanitarian aid. Moving towards the development of solutions to these complex problem spaces depends on the lens we use to examine them and how we frame the problem. It will be shown that systems thinking and soft operations research has had great success in contributing to the management of complexity. .

  16. A Research On Perceptions About Management Problems of Professional Accountants

    Directory of Open Access Journals (Sweden)

    Nurettin İBRAHİMOĞLU

    2014-12-01

    Full Text Available The aim of this study is to investigate the perception of administrative problems of professional accountants and to bring some solutions to their problems. The study was attended by 304 members of the accounting profession (N=304. The sample of this study was generated from the professional accountants registered to the Chamber of Gaziantep Public Accountants and Financial Advisers in Gaziantep region. Literature sources related to this problem was overviewed and some broad information about the sample and study was presented. We employed factor analysis to analyze the data. The perception of administrative problems of the accounting professionals are discussed by three factors which can be classified as follow; occupational problems, health problems, and training – communication problems. The hypotheses of this study was divided to groups and was tested by Mann - Whitney U test which is a non-parametric method alternative to t-test. According to findings of this study the most important problems of the professional accountants is classified as follow; the costumer, customer (taxpayers relationship problems, unethical request of the customers, stressful working conditions and it also found that the professional accountants with in this sample does not meet all demands of the customers

  17. Instructional Design-Based Research on Problem Solving Strategies

    Science.gov (United States)

    Emre-Akdogan, Elçin; Argün, Ziya

    2016-01-01

    The main goal of this study is to find out the effect of the instructional design method on the enhancement of problem solving abilities of students. Teaching sessions were applied to ten students who are in 11th grade, to teach them problem solving strategies which are working backwards, finding pattern, adopting a different point of view,…

  18. Discovery of HeLa Cell Contamination in HES Cells: Call for Cell Line Authentication in Reproductive Biology Research.

    Science.gov (United States)

    Kniss, Douglas A; Summerfield, Taryn L

    2014-08-01

    Continuous cell lines are used frequently in reproductive biology research to study problems in early pregnancy events and parturition. It has been recognized for 50 years that many mammalian cell lines contain inter- or intraspecies contaminations with other cells. However, most investigators do not routinely test their culture systems for cross-contamination. The most frequent contributor to cross-contamination of cell lines is the HeLa cell isolated from an aggressive cervical adenocarcinoma. We report on the discovery of HeLa cell contamination of the human endometrial epithelial cell line HES isolated in our laboratory. Short tandem repeat analysis of 9 unique genetic loci demonstrated molecular identity between HES and HeLa cells. In addition, we verified that WISH cells, isolated originally from human amnion epithelium, were also contaminated with HeLa cells. Inasmuch as our laboratory did not culture HeLa cells at the time of HES cell derivations, the source of contamination was the WISH cell line. These data highlight the need for continued diligence in authenticating cell lines used in reproductive biology research. © The Author(s) 2014.

  19. Stem Cell Research: Unlocking the Mystery of Disease

    Science.gov (United States)

    ... Home Current Issue Past Issues From the Director: Stem Cell Research: Unlocking the Mystery of Disease Past Issues / ... Zerhouni, NIH Director, described the need for expanding stem cell research. Recently, he spoke about stem cell research ...

  20. Translational findings from cardiovascular stem cell research.

    Science.gov (United States)

    Mazhari, Ramesh; Hare, Joshua M

    2012-01-01

    The possibility of using stem cells to regenerate damaged myocardium has been actively investigated since the late 1990s. Consistent with the traditional view that the heart is a "postmitotic" organ that possesses minimal capacity for self-repair, much of the preclinical and clinical work has focused exclusively on introducing stem cells into the heart, with the hope of differentiation of these cells into functioning cardiomyocytes. This approach is ongoing and retains promise but to date has yielded inconsistent successes. More recently, it has become widely appreciated that the heart possesses endogenous repair mechanisms that, if adequately stimulated, might regenerate damaged cardiac tissue from in situ cardiac stem cells. Accordingly, much recent work has focused on engaging and enhancing endogenous cardiac repair mechanisms. This article reviews the literature on stem cell-based myocardial regeneration, placing emphasis on the mutually enriching interaction between basic and clinical research. Copyright © 2012 Elsevier Inc. All rights reserved.

  1. Resolution on the problems and prospects of common research policy

    International Nuclear Information System (INIS)

    1982-01-01

    The European Parliament sets priorities for future research policy; it supports e.g.: the Europeanization of large-scale research because it shall facilitate the combination of the research and financing potential. It also secures a wide adaptation of the knowledge achieved by the joint financial efforts of all member states. The demander made for a joint research project are: that the next programme for several years of the joint research project may launch its position and special qualification as a safety research centre for industrial activities of high risks (nuclear energy sector, chemistry, biology) and that the joint research project may be organized as independently as possible. Moreover, the European Parliament demands that the member states increase their research budgets to at least 2.5% of the gross national product. (orig./HSCH) [de

  2. The Ethical Problems of Reserach : An empirical study of ethics in research practice

    OpenAIRE

    Colnerud, Gunnel

    2013-01-01

    Most accounts of the ethical problems facing researchers across a broad spectrum of research fields come from ethicists, ethics committees and specialists committed to the study of ethics in human research. In contrast, this study reports on the ethical questions that researchers, themselves, report facing in their everyday practice. Fifty-five Swedish researchers contributed 109 examples of ethical dilemmas, conflicts and problems in research. They were all researchers at the post-doctoral l...

  3. Issues and Ethical Problems of Stem Cell Therapy – Where is Hippocrates?

    Directory of Open Access Journals (Sweden)

    Lucie Rousková

    2008-01-01

    Full Text Available Stem cells and their therapeutic use present many questions associated with ethical problems in medicine. There is great effort on the part of physicians to help millions of patients while there are ethical problems with the use of new methods and technologies and all of these are affected by economic and political influences. How will the current generation deal with these problems? Medicine, in this begard, is experiencing a stormy evolution of human culture in the relationships between disease, patient and doctor. Philosophy approaches the same juncture of human culture, but seemingly from the other side. Both disciplines are facing a great problem: How to unite the content of current human morality and the desire for health? Both philosophers and physicians perceive this deficit in human culture as it does not provide immediately usable normatives, which the living generation of healthy and ill is waiting for. It may be said that medicine, as many times before, has reached a stage where it cannot rely only on the proved axiologic values from the past, ethical normatives or cultivated moral sense of its subjects. Medicine has no other alternative than to take an active part in resolution of interdisciplinary problems originating from philosophic-biologic or philosophic-medical inquiries of axiologic, ethical, and moral issues. Our paper indicates some ways of the search in forming ethical principles of the stem-cell therapy from the view of biologists and physicians. New ways are recommended in theoretical-methodological interdisciplinary research, especially, in theoretical and experimental biology, and theoretical and clinical medicine, as well as philosophy. In this paper important ethical problems are pointed out in order to find answers to some key problems connected with cell therapy and the use of stem cells.

  4. Applications of behavioural research on spatial problems I: cognition

    NARCIS (Netherlands)

    Golledge, R.G.; Timmermans, H.J.P.

    1990-01-01

    In this, the first of a two-part sequence, we have first discussed some critical features of early behavioural research in geography, then traced developments following from this early research to the current period. We emphasized the early applied nature of much of this research. We have also shown

  5. What Undergraduates Misunderstand about Stem Cell Research

    Science.gov (United States)

    Halverson, Kristy Lynn; Freyermuth, Sharyn K.; Siegel, Marcelle A.; Clark, Catharine G.

    2010-01-01

    As biotechnology-related scientific advances, such as stem cell research (SCR), are increasingly permeating the popular media, it has become ever more important to understand students' ideas about this issue. Very few studies have investigated learners' ideas about biotechnology. Our study was designed to understand the types of alternative…

  6. On the Problem of Validity of Qualitative Research

    Directory of Open Access Journals (Sweden)

    Jo Reichertz

    2000-06-01

    Full Text Available Whether the research results put forth by (social scientists on behalf of their professional vocation and on behalf of their professional standards they adhere to, can be regarded as valid, shall be examined from the perspective of the sociology of knowledge. By means of applying the sociology of knowledge to its own research results, it shall be shown that research and research results are inevitably bound to perspective (in fact, not a surprising insight. Therefore—so the underlying thesis of the argument—, research must be aimed at the systematic production of doubt in order to facilitate maximum extinction of fault. Suggestions are advanced of how qualitative research projects can be defended despite the increasing competition regarding research grants and despite the problematic epistemological position. URN: urn:nbn:de:0114-fqs0002324

  7. Research Advances of Social Security Problems in China —Visualization Research based on Bibliometrics

    Institute of Scientific and Technical Information of China (English)

    赵琳

    2016-01-01

    This article summarized the research progress and characteristics of Chinese social security issues from 2000 papers, which record in CNKI. We find that, the topic in the field of social security is board and dispersion. Due to the huge system and complex problem of social security, there is no central theme. Through cluster analysis, multi dimensional scaling analysis and social network analysis, we got the high frequency keywords atlas. Then, we summarized the research topic to six parts. They are rural social security, urban and rural social security co-ordination, vulnerable group social security, social security fund management, the social insurance system, and social security system and government responsibility. It summed up the theme of the module, meanwhile, combined the practice analysis.

  8. An exploration of knowledge integration problems in interdisciplinary research teams

    NARCIS (Netherlands)

    Bayerl, P.S.; Steinheider, B.

    2009-01-01

    The integration of function-specific expertise into a shared knowledge base is a crucial, but complex process for success in interdisciplinary teams. This paper presents an empirically derived typology of knowledge integration problems and links their occurrence to degree of heterogeneity and

  9. Research activity on thermohydraulic problems of PWR reactors

    International Nuclear Information System (INIS)

    Szabados, L.

    1976-06-01

    The general review of the experimental and theoretical research works on thermohydraulic investigation of pressurized water type reactors being done in the Central Research Institute for Physics is given. The main results of the theoretical and theoretical-numerical research are summarized. The most important result of the past years is the construction of the High Pressure Water Cooled Loop (NVH) thermohydraulic loop. Another significant achievement was the development of the reactor thermohydraulic program system. (Sz.N.Z.)

  10. Problems Encountered during the Scientific Research Process in Graduate Education: The Institute of Educational Sciences

    Science.gov (United States)

    Akyürek, Erkan; Afacan, Özlem

    2018-01-01

    This study was conducted to determine the problems faced by graduate students when conducting scientific research and to make suggestions for solving these problems. The research model was a case study. Semi-structured interviews were conducted with participants in the study with questions about the problems encountered during scientific research…

  11. Problems of Conducting Research in Organizations: The Case of Police Departments.

    Science.gov (United States)

    Lefkowitz, Joel

    This paper presents a description of police research problems in such fashion that it could be generalized to other types of organizations. A two-dimensional taxonomy of problems in conducting psychological research in police departments is discussed. The first dimension concerns generality-uniqueness of the problem, relative to formal…

  12. 34 CFR 356.11 - What types of problems may be researched under the fellowship program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false What types of problems may be researched under the... (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION DISABILITY AND... Program? § 356.11 What types of problems may be researched under the fellowship program? Problems...

  13. Practices of Legitimacy and the Problem of Artistic Research

    Science.gov (United States)

    Matcham, David

    2014-01-01

    This paper examines the positioning of art practice as a mode of research through various legitimising practices. While frequently fruitful, the imperative to make art justify itself as a form of research in order to achieve legitimacy allows that in art which does not engage in negative dialectics to slip from view. The possibility of the kind of…

  14. Micronutrient problems in Thailand - extent, past and present research

    International Nuclear Information System (INIS)

    Snitwongse, P.

    1975-01-01

    Micronutrient problems in Thailand are briefly discussed, particularly with reference to rice. At present, the relative amounts of zinc in rice-growing areas (soils) are being analyzed for total and available zinc. Fertilizer (N, P, K) uptake by rice is being studied in the field by means of zinc-65. Observations on the relative uptake of P by rice associated with different zinc levels are made on pot cultures, using phosphorus-32

  15. Research Projects in Physics: A Mechanism for Teaching Ill-Structured Problem Solving

    Science.gov (United States)

    Milbourne, Jeff; Bennett, Jonathan

    2017-10-01

    Physics education research has a tradition of studying problem solving, exploring themes such as physical intuition and differences between expert and novice problem solvers. However, most of this work has focused on traditional, or well-structured, problems, similar to what might appear in a textbook. Less work has been done with open-ended, or ill-structured, problems, similar to the types of problems students might face in their professional lives. Given the national discourse on educational system reform aligned with 21st century skills, including problem solving, it is critical to provide educational experiences that help students learn to solve all types of problems, including ill-structured problems.

  16. Research on Life Science and Life Support Engineering Problems of Manned Deep Space Exploration Mission

    Science.gov (United States)

    Qi, Bin; Guo, Linli; Zhang, Zhixian

    2016-07-01

    Space life science and life support engineering are prominent problems in manned deep space exploration mission. Some typical problems are discussed in this paper, including long-term life support problem, physiological effect and defense of varying extraterrestrial environment. The causes of these problems are developed for these problems. To solve these problems, research on space life science and space medical-engineering should be conducted. In the aspect of space life science, the study of space gravity biology should focus on character of physiological effect in long term zero gravity, co-regulation of physiological systems, impact on stem cells in space, etc. The study of space radiation biology should focus on target effect and non-target effect of radiation, carcinogenicity of radiation, spread of radiation damage in life system, etc. The study of basic biology of space life support system should focus on theoretical basis and simulating mode of constructing the life support system, filtration and combination of species, regulation and optimization method of life support system, etc. In the aspect of space medical-engineering, the study of bio-regenerative life support technology should focus on plants cultivation technology, animal-protein production technology, waste treatment technology, etc. The study of varying gravity defense technology should focus on biological and medical measures to defend varying gravity effect, generation and evaluation of artificial gravity, etc. The study of extraterrestrial environment defense technology should focus on risk evaluation of radiation, monitoring and defending of radiation, compound prevention and removal technology of dust, etc. At last, a case of manned lunar base is analyzed, in which the effective schemes of life support system, defense of varying gravity, defense of extraterrestrial environment are advanced respectively. The points in this paper can be used as references for intensive study on key

  17. 3 CFR - Guidelines for Human Stem Cell Research

    Science.gov (United States)

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Guidelines for Human Stem Cell Research Presidential Documents Other Presidential Documents Memorandum of July 30, 2009 Guidelines for Human Stem Cell Research..., scientifically worthy human stem cell research, including human embryonic stem cell research, to the extent...

  18. Corrosion problem in the CRENK Triga Mark II research reactor

    International Nuclear Information System (INIS)

    Kalenga, M.

    1990-01-01

    In August 1987, a routine underwater optical inspection of the aluminum tank housing the core of the CRENK Triga Mark II reactor, carried out to update safety condition of the reactor, revealed pitting corrosion attacks on the 8 mm thick aluminum tank bottom. The paper discuss the work carried out by the reactor staff to dismantle the reactor in order to allow a more precise investigation of the corrosion problem, to repair the aluminum tank bottom, and to enhance the reactor overall safety condition

  19. A genetic algorithm for a bi-objective mathematical model for dynamic virtual cell formation problem

    Science.gov (United States)

    Moradgholi, Mostafa; Paydar, Mohammad Mahdi; Mahdavi, Iraj; Jouzdani, Javid

    2016-09-01

    Nowadays, with the increasing pressure of the competitive business environment and demand for diverse products, manufacturers are force to seek for solutions that reduce production costs and rise product quality. Cellular manufacturing system (CMS), as a means to this end, has been a point of attraction to both researchers and practitioners. Limitations of cell formation problem (CFP), as one of important topics in CMS, have led to the introduction of virtual CMS (VCMS). This research addresses a bi-objective dynamic virtual cell formation problem (DVCFP) with the objective of finding the optimal formation of cells, considering the material handling costs, fixed machine installation costs and variable production costs of machines and workforce. Furthermore, we consider different skills on different machines in workforce assignment in a multi-period planning horizon. The bi-objective model is transformed to a single-objective fuzzy goal programming model and to show its performance; numerical examples are solved using the LINGO software. In addition, genetic algorithm (GA) is customized to tackle large-scale instances of the problems to show the performance of the solution method.

  20. Examining problem solving in physics-intensive Ph.D. research

    Science.gov (United States)

    Leak, Anne E.; Rothwell, Susan L.; Olivera, Javier; Zwickl, Benjamin; Vosburg, Jarrett; Martin, Kelly Norris

    2017-12-01

    Problem-solving strategies learned by physics undergraduates should prepare them for real-world contexts as they transition from students to professionals. Yet, graduate students in physics-intensive research face problems that go beyond problem sets they experienced as undergraduates and are solved by different strategies than are typically learned in undergraduate coursework. This paper expands the notion of problem solving by characterizing the breadth of problems and problem-solving processes carried out by graduate students in physics-intensive research. We conducted semi-structured interviews with ten graduate students to determine the routine, difficult, and important problems they engage in and problem-solving strategies they found useful in their research. A qualitative typological analysis resulted in the creation of a three-dimensional framework: context, activity, and feature (that made the problem challenging). Problem contexts extended beyond theory and mathematics to include interactions with lab equipment, data, software, and people. Important and difficult contexts blended social and technical skills. Routine problem activities were typically well defined (e.g., troubleshooting), while difficult and important ones were more open ended and had multiple solution paths (e.g., evaluating options). In addition to broadening our understanding of problems faced by graduate students, our findings explore problem-solving strategies (e.g., breaking down problems, evaluating options, using test cases or approximations) and characteristics of successful problem solvers (e.g., initiative, persistence, and motivation). Our research provides evidence of the influence that problems students are exposed to have on the strategies they use and learn. Using this evidence, we have developed a preliminary framework for exploring problems from the solver's perspective. This framework will be examined and refined in future work. Understanding problems graduate students

  1. Examining problem solving in physics-intensive Ph.D. research

    Directory of Open Access Journals (Sweden)

    Anne E. Leak

    2017-07-01

    Full Text Available Problem-solving strategies learned by physics undergraduates should prepare them for real-world contexts as they transition from students to professionals. Yet, graduate students in physics-intensive research face problems that go beyond problem sets they experienced as undergraduates and are solved by different strategies than are typically learned in undergraduate coursework. This paper expands the notion of problem solving by characterizing the breadth of problems and problem-solving processes carried out by graduate students in physics-intensive research. We conducted semi-structured interviews with ten graduate students to determine the routine, difficult, and important problems they engage in and problem-solving strategies they found useful in their research. A qualitative typological analysis resulted in the creation of a three-dimensional framework: context, activity, and feature (that made the problem challenging. Problem contexts extended beyond theory and mathematics to include interactions with lab equipment, data, software, and people. Important and difficult contexts blended social and technical skills. Routine problem activities were typically well defined (e.g., troubleshooting, while difficult and important ones were more open ended and had multiple solution paths (e.g., evaluating options. In addition to broadening our understanding of problems faced by graduate students, our findings explore problem-solving strategies (e.g., breaking down problems, evaluating options, using test cases or approximations and characteristics of successful problem solvers (e.g., initiative, persistence, and motivation. Our research provides evidence of the influence that problems students are exposed to have on the strategies they use and learn. Using this evidence, we have developed a preliminary framework for exploring problems from the solver’s perspective. This framework will be examined and refined in future work. Understanding problems

  2. Translational research: cells, tissues and organisms

    International Nuclear Information System (INIS)

    Chang, P.Y.

    2003-01-01

    Exposure to the complex space radiation environment poses an important health hazard for astronauts in long-term space missions. The central theme of NASA's space radiation health research effort is to acquire scientific knowledge to understand the mechanisms of particle radiation effects in biological systems and to use this knowledge to set exposure limits and to design countermeasures that will protect the astronauts. During the past few decades, a rich body of data has been developed to characterize HZE-induced biological responses both in vitro and in vivo using ground-based accelerator facilities available in a number of facilities around the world. Although much is known about particle-radiation-induced DNA damage and cell killing in cultured cell lines, recent evidence suggest that numerous other factors, such as membrane effects, altered gene expression, bystander effects and specific cell-type dependent features also play critical roles in cellular responses. Dose- and particle-dependent studies are also available for multicellular tissues and animal model systems where emerging information demonstrates complex interactions between cells including intercellular communications, activation of proteins, alterations in the microenvironment, tissue-specificity, and genetic status and these contribute in determining the consequences of HZE radiation. Due to the lack of human data, risk estimates depend on the extrapolation of experimental results in animals and cultured cell systems to man. In this presentation, selected topics reviewing particle radiation effects in cells, tissues and animal will be used to illustrate the importance of translational research and some of the limitations of such approaches

  3. The study of electrochemical cell taught by problem-based learning

    Science.gov (United States)

    Srichaitung, Paisan

    2018-01-01

    According to the teaching activity of Chemistry, researcher found that students were not able to seek self knowledge even applied knowledge to their everyday life. Therefore, the researcher is interested in creating an activity to have students constructed their knowledge, science process skills, and can apply knowledge in their everyday life. The researcher presented form of teaching activity of electrochemical cell by using problem-based learning for Mathayom five students of Thai Christian School. The teaching activity focused on electron transfer in galvanic cell. In this activity, the researcher assigned students to design the electron transfer in galvanic cell using any solution that could light up the bulb. Then students were separated into a group of two, which were total seven groups. Each group of students searched the information about the electron transfer in galvanic cell from books, internet, or other sources of information. After students received concepts, or knowledge they searched for, Students designed and did the experiment. Finally, the students in each groups had twenty minutes to give a presentation in front of the classroom about the electron transfer in galvanic using any solution to light up the bulb with showing the experiment, and five minutes to answer their classmates' questions. Giving the presentation took four periods with total seven groups. After students finished their presentation, the researcher had students discussed and summarized the teaching activity's main idea of electron transfer in galvanic. Then, researcher observed students' behavior in each group found that 85.7 percentages of total students developed science process skills, and transferred their knowledge through presentation completely. When students done the post test, the researcher found that 92.85 percentages of total students were able to explain the concept of galvanic cell, described the preparation and the selection of experimental equipment. Furthermore

  4. RESEARCH ON ENVIRONMENTAL HEALTH INTERVENTIONS: ETHICAL PROBLEMS AND SOLUTIONS

    Science.gov (United States)

    RESNIK, DAVID B.; ZELDIN, DARRYL C.; SHARP, RICHARD R.

    2014-01-01

    This article reviews a variety of ethical issues one must consider when conducting research on environmental health interventions on human subjects. The paper uses the Kennedy Krieger Institute lead abatement study as well as a hypothetical asthma study to discuss questions concerning benefits and risks, risk minimization, safety monitoring, the duty to warn, the duty to report, the use of control groups, informed consent, equitable subject selection, privacy, conflicts of interest, and community consultation. Research on environmental health interventions can make an important contribution to our understanding of human health and disease prevention, provided it is conducted in a manner that meets prevailing scientific, ethical, and legal standards for research on human subjects. PMID:16220621

  5. Research briefing on contemporary problems in plasma science

    International Nuclear Information System (INIS)

    1991-01-01

    An overview is presented of the broad perspective of all plasma science. Detailed discussions are given of scientific opportunities in various subdisciplines of plasma science. The first subdiscipline to be discussed is the area where the contemporary applications of plasma science are the most widespread, low temperature plasma science. Opportunities for new research and technology development that have emerged as byproducts of research in magnetic and inertial fusion are then highlighted. Then follows a discussion of new opportunities in ultrafast plasma science opened up by recent developments in laser and particle beam technology. Next, research that uses smaller scale facilities is discussed, first discussing non-neutral plasmas, and then the area of basic plasma experiments. Discussions of analytic theory and computational plasma physics and of space and astrophysical plasma physics are then presented

  6. Nutrition Research Agenda in the Context of Nutrition Problems in ...

    African Journals Online (AJOL)

    2010-04-02

    Apr 2, 2010 ... health metrics are used to assess overall food. Nutrition Research ... or dietary planning although use of a diet quality ...... Jiang, Y., Jolly, P.E., Preko, P., Wang, J.S.,. Ellis, W.O. ... Hindawi Publishing Corporation, Article.

  7. Higher Education Research in Uganda: Problems and Prospects

    Science.gov (United States)

    Owoeye, J. S.; Oyebade, S. A.

    2010-01-01

    Research is regarded as essential for development and the application of new knowledge for the benefit of society. Higher education in Uganda has expanded rapidly in the last 20 years. Universities have become the most important institutions in the achievement of national and international goals in enhancing the quality of life, wealth creation,…

  8. Design Research on Personalized Problem Posing in Algebra

    Science.gov (United States)

    Walkington, Candace

    2017-01-01

    Algebra is an area of pressing national concern around issues of equity and access in education. Recent theories and research suggest that personalization of instruction can allow students to activate their funds of knowledge and can elicit interest in the content to be learned. This paper examines the results of a large-scale teaching experiment…

  9. Inhaled actinides: some safety issues and some research problems

    International Nuclear Information System (INIS)

    Bair, W.J.

    1978-01-01

    The following topics are discussed: limited research funds; risk coefficients for inhaled particles; the hot particle hypothesis; the Gofman-Martell contention; critical tissues for inhaled actinides inhalation hazards associated with future nuclear fuel cycles; and approach to be used by the inhalation panel

  10. Problems with a False Recognition Paradigm for Developmental Memory Research

    Science.gov (United States)

    Lindauer, Barbara K.; Paris, Scott G.

    1976-01-01

    Developmental changes in memory organization based on synonym and antonym relationships were examined in three experiments. Subjects were 64 second graders and 64 sixth graders. Some inadequacies of a false recognition paradigm for developmental research are identified and some alternative analyses are proposed. (Author/JH)

  11. TRANSPARENT COATINGS FOR SOLAR CELLS RESEARCH

    Energy Technology Data Exchange (ETDEWEB)

    Glatkowski, P. J.; Landis, D. A.

    2013-04-16

    Todays solar cells are fabricated using metal oxide based transparent conductive coatings (TCC) or metal wires with optoelectronic performance exceeding that currently possible with Carbon Nanotube (CNT) based TCCs. The motivation for replacing current TCC is their inherent brittleness, high deposition cost, and high deposition temperatures; leading to reduced performance on thin substrates. With improved processing, application and characterization techniques Nanofiber and/or CNT based TCCs can overcome these shortcomings while offering the ability to be applied in atmospheric conditions using low cost coating processes At todays level of development, CNT based TCC are nearing commercial use in touch screens, some types of information displays (i.e. electronic paper), and certain military applications. However, the resistivity and transparency requirements for use in current commercial solar cells are more stringent than in many of these applications. Therefore, significant research on fundamental nanotube composition, dispersion and deposition are required to reach the required performance commanded by photovoltaic devices. The objective of this project was to research and develop transparent conductive coatings based on novel nanomaterial composite coatings, which comprise nanotubes, nanofibers, and other nanostructured materials along with binder materials. One objective was to show that these new nanomaterials perform at an electrical resistivity and optical transparency suitable for use in solar cells and other energy-related applications. A second objective was to generate new structures and chemistries with improved resistivity and transparency performance. The materials also included the binders and surface treatments that facilitate the utility of the electrically conductive portion of these composites in solar photovoltaic devices. Performance enhancement venues included: CNT purification and metallic tube separation techniques, chemical doping, CNT

  12. Problems Teachers Face When Doing Action Research and Finding Possible Solutions: Three Cases

    Science.gov (United States)

    Zhou, Jun

    2012-01-01

    Through case studies, this paper explores problems teachers face when doing action research: for instance, teachers may misunderstand the research, mistrust university researchers, lack the time or adequate library resources to conduct research, lack theoretical guidance or knowledge of research methodology, and feel pressure or frustration during…

  13. REFRIGERANT/LUBRICANT MIXTURES: PROBLEMS OF APPLICATION AND PROPERTY RESEARCH

    Directory of Open Access Journals (Sweden)

    Yu. Semenyuk

    2013-10-01

    Full Text Available The results and generalizations of thermophysical property research for the refrigerant/lubricant mixtures are summarized. The methodological aspects of the experimental studies of the thermal properties of real working media for vapor compression refrigeration machines and the general principles of the thermodynamic properties simulation for such solutions are analyzed. It is shown that the admixtures of compressor oil in the refrigerant make the efficiency parameters of compressor systems much lower. The question of a selective solubility of the multicomponent refrigerants in compressor oils is discussed.

  14. Texts of the New Nature: Problems of Interdisciplinary Research

    Directory of Open Access Journals (Sweden)

    Kazakova E.I.,

    2017-02-01

    Full Text Available The paper explores a new research direction unfolding at the junction of modern textual criticism and modernization challenges in education. It outlines the theoretical basis for constructing a model of the «new literacy» representative of the 21st century. The paper contains an attempt to describe the main trends in the changes of text: rejection of linearity, shrinkage of text volume, orientation to «small text structures», duplicative character of different sign systems in the content reflection, increase of interactivity, feedback forms development, emergence of «new forms of authorship» and a number of other trends. Examples are given of new literature, created in the form of comics, presentations, infographics, drawn notes. The author reveals the scope of «the texts of the new nature» through the provision of its characteristics; describes two main technologies of formation of such texts; provides experimental data that characterize the process of perception of this kind of texts; and, finally, formulates priority research issues.

  15. Research Projects in Physics: A Mechanism for Teaching Ill-Structured Problem Solving

    Science.gov (United States)

    Milbourne, Jeff; Bennett, Jonathan

    2017-01-01

    Physics education research has a tradition of studying problem solving, exploring themes such as physical intuition and differences between expert and novice problem solvers. However, most of this work has focused on traditional, or well-structured, problems, similar to what might appear in a textbook. Less work has been done with open-ended, or…

  16. Vessel-related problems in severe accidents, International Research Projects

    International Nuclear Information System (INIS)

    Figueras, J. M.

    2000-01-01

    The paper describes those most relevant aspects of research programmes and projects, on the behavior of vessel during severe accidents with partial or total reactor core fusion, performed during the last twenty years or still on-going projects, by countries or international organizations in the nuclear community, presenting the most important technical aspects, in particular the results achieved, as well as the financial and organisational aspects. The paper concludes that, throughout a joint effort of the international nuclear community, in which Spain has been present via private and public organizations, actually exist a reasonable technical and experimental knowledge of the vessel in case of severe accidents, but still there are aspects not fully solved which are the basis for continuing some programmes and for proposal of new ones. (Author)

  17. Mathematical models of physics problems (physics research and technology)

    CERN Document Server

    Anchordoqui, Luis Alfredo

    2013-01-01

    This textbook is intended to provide a foundation for a one-semester introductory course on the advanced mathematical methods that form the cornerstones of the hard sciences and engineering. The work is suitable for first year graduate or advanced undergraduate students in the fields of Physics, Astronomy and Engineering. This text therefore employs a condensed narrative sufficient to prepare graduate and advanced undergraduate students for the level of mathematics expected in more advanced graduate physics courses, without too much exposition on related but non-essential material. In contrast to the two semesters traditionally devoted to mathematical methods for physicists, the material in this book has been quite distilled, making it a suitable guide for a one-semester course. The assumption is that the student, once versed in the fundamentals, can master more esoteric aspects of these topics on his or her own if and when the need arises during the course of conducting research. The book focuses on two cor...

  18. Mixed Methods Research: The "Thing-ness" Problem.

    Science.gov (United States)

    Hesse-Biber, Sharlene

    2015-06-01

    Contemporary mixed methods research (MMR) veers away from a "loosely bounded" to a "bounded" concept that has important negative implications for how qualitatively driven mixed methods approaches are positioned in the field of mixed methods and overall innovation in the praxis of MMR. I deploy the concept of reification defined as taking an object/abstraction and treating it as if it were real such that it takes on the quality of "thing-ness," having a concrete independent existence. I argue that the contemporary reification of mixed methods as a "thing" is fueled by three interrelated factors: (a) the growing formalization of mixed methods as design, (b) the unexamined belief in the "synergy" of mixed methods and, (c) the deployment of a "practical pragmatism" as the "philosophical partner" for mixed methods inquiry. © The Author(s) 2015.

  19. Topical problems of corrosion research for nuclear power purposes

    International Nuclear Information System (INIS)

    Eremias, B.

    1978-01-01

    Currently, research is focused on stress corrosion, intergranular corrosion, corrosion in water and steam, hydrogen-induced corrosion and corrosion in liquid sodium. The effort to limit stress corrosion resulted in the application of high nickel content austenitic steels. In these steels, the susceptibility to stress corrosion is mainly affected by previous heat treatment and the presence of chloride ions. Attention is also paid to medium and high-alloy chromium steels and susceptibility is studied to intergranular corrosion and stress corrosion. Of low-alloy steels the 21/4Cr-1Mo type steels stabilized with Nb or nonstabilized are studied with respect to decarburization kinetics and changes in mechanical properties in the presence of hydrogen. Of nonferrous metals zirconium alloys are studied used as cladding materials for fuel elements, mainly Zircaloy 2 and 4, with regard to their resistance to high-temperature oxidation, high-pressure steam action, etc. (J.F.)

  20. Migration: The Present State, Problems and Perspectives of Research Paradigms

    Directory of Open Access Journals (Sweden)

    Silva Mežnarić

    2003-12-01

    Full Text Available Two prevailing paradigms in contemporary international migration research – migration as unpredictable explosion and migration as mainly predictable long cycles movement – are put into question. Both paradigms are not valid in explaining latest development in international migration field. They are too robust for reality which is satiated with novel developments in the field of volume, directions, labour markets and structure of migration flows, both voluntary and involuntary. Individual independent migrant as decision maker is coming to the fore. Therefore the reassessment of theoretical and conceptual apparatus of migration is imminent. As to the methods, mathematically supported sociological models of contemporary migration could be needed. On the basis of “new intuition”, the principles of simplicity, parsimony, and universality could lead to a theoretical innovation.

  1. Lingua-Pedagogy as the Interdisciplinary Research Problem

    Directory of Open Access Journals (Sweden)

    A. N. Yakovleva

    2012-01-01

    Full Text Available  The paper is devoted to lingua-pedagogy – one of the modern branches of pedagogy dealing with personal socialization in the process of foreign language learning. This interdisciplinary field of knowledge is related to linguistics, pedagogic psychology, development psychology and acmeology. Lingua-pedagogy undergoes the formation process; therefore, there still are a number of open questions concerning its place among the other sciences, and the final definitions of the main concepts and terms. The author recommends the systematic approach to developing the theoretical foundation of lingua- pedagogy. The paper outlines the subject and aims of the lingua-pedagogic research, its content and affecting means. The system in question is poly- functional, its main functions being the integral pedagogic effect in foreign language teaching, stimulating self-dependent learning, and arranging the in- tercultural integration. The linguistic faculties at universities can be taken as the key elements of the lingua-pedagogic system – the development centers, nurturing the value-oriented respectful attitude to the native and foreign cul- ture, providing intercultural competence acquisition, and training pedagogic staff capable of fulfilling the poly-cultural development tasks. Identification of the conformities of intercultural socialization makes it possible to organize the system of pedagogic facilitation for students learning foreign languages; and develop the perspective methods and technologies of language competence acquisition and consolidation. 

  2. [Advances in the research of function of Merkel cells in tactile formation of skin].

    Science.gov (United States)

    You, X; Wei, Z R

    2018-01-20

    Skin is the largest sense organ of human, with many mechanoreceptor cells under epidermis or dermis of skin and Merkel cell is one of them. It has been confirmed that Merkel cells play an important role in the process of mechanical transmission of mammalian soft tactile stimulation. Researches showed that Merkel cells had close relation to tactile formation and functioned by Merkel cell-neurite complexes and ion channels Piezo2. This article reviews Merkel cells and the function, problem and prospect of Merkel cells in tactile formation.

  3. Recent Research Trends in Genetic Algorithm Based Flexible Job Shop Scheduling Problems

    OpenAIRE

    Amjad, Muhammad Kamal; Butt, Shahid Ikramullah; Kousar, Rubeena; Ahmad, Riaz; Agha, Mujtaba Hassan; Faping, Zhang; Anjum, Naveed; Asgher, Umer

    2018-01-01

    Flexible Job Shop Scheduling Problem (FJSSP) is an extension of the classical Job Shop Scheduling Problem (JSSP). The FJSSP is known to be NP-hard problem with regard to optimization and it is very difficult to find reasonably accurate solutions of the problem instances in a rational time. Extensive research has been carried out in this area especially over the span of the last 20 years in which the hybrid approaches involving Genetic Algorithm (GA) have gained the most popularity. Keeping in...

  4. Data Linkage: A powerful research tool with potential problems

    Directory of Open Access Journals (Sweden)

    Scott Ian

    2010-12-01

    Full Text Available Abstract Background Policy makers, clinicians and researchers are demonstrating increasing interest in using data linked from multiple sources to support measurement of clinical performance and patient health outcomes. However, the utility of data linkage may be compromised by sub-optimal or incomplete linkage, leading to systematic bias. In this study, we synthesize the evidence identifying participant or population characteristics that can influence the validity and completeness of data linkage and may be associated with systematic bias in reported outcomes. Methods A narrative review, using structured search methods was undertaken. Key words "data linkage" and Mesh term "medical record linkage" were applied to Medline, EMBASE and CINAHL databases between 1991 and 2007. Abstract inclusion criteria were; the article attempted an empirical evaluation of methodological issues relating to data linkage and reported on patient characteristics, the study design included analysis of matched versus unmatched records, and the report was in English. Included articles were grouped thematically according to patient characteristics that were compared between matched and unmatched records. Results The search identified 1810 articles of which 33 (1.8% met inclusion criteria. There was marked heterogeneity in study methods and factors investigated. Characteristics that were unevenly distributed among matched and unmatched records were; age (72% of studies, sex (50% of studies, race (64% of studies, geographical/hospital site (93% of studies, socio-economic status (82% of studies and health status (72% of studies. Conclusion A number of relevant patient or population factors may be associated with incomplete data linkage resulting in systematic bias in reported clinical outcomes. Readers should consider these factors in interpreting the reported results of data linkage studies.

  5. Research on energy transmission calculation problem on laser detecting submarine

    Science.gov (United States)

    Fu, Qiang; Li, Yingchao; Zhang, Lizhong; Wang, Chao; An, Yan

    2014-12-01

    The laser detection and identification is based on the method of using laser as the source of signal to scan the surface of ocean. If the laser detection equipment finds out the target, it will immediately reflect the returning signal, and then through receiving and disposing the returning signal by the receiving system, to realize the function of detection and identification. Two mediums channels should be though in the process of laser detection transmission, which are the atmosphere and the seawater. The energy loss in the process of water transport, mainly considering the surface reflection and scattering attenuation and internal attenuation factors such as seawater. The energy consumption though atmospheric transmission, mainly considering the absorption of atmospheric and the attenuation causing by scattering, the energy consumption though seawater transmission, mainly considering the element such as surface reflection, the attenuation of scattering and internal attenuation of seawater. On the basis of the analysis and research, through the mode of establishment of atmospheric scattering, the model of sea surface reflection and the model of internal attenuation of seawater, determine the power dissipation of emitting lasers system, calculates the signal strength that reaches the receiver. Under certain conditions, the total attenuation of -98.92 dB by calculation, and put forward the related experiment scheme by the use of Atmospheric analog channel, seawater analog channel. In the experiment of the theory, we use the simulation pool of the atmosphere and the sea to replace the real environment where the laser detection system works in this kind of situation. To start with, we need to put the target in the simulating seawater pool of 10 meters large and then control the depth of the target in the sea level. We, putting the laser detection system in position where it is 2 kilometers far from one side, secondly use the equipment to aim at the target in some

  6. Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.

    Science.gov (United States)

    Smith, Rosanna C G; Stumpf, Patrick S; Ridden, Sonya J; Sim, Aaron; Filippi, Sarah; Harrington, Heather A; MacArthur, Ben D

    2017-06-20

    A number of important pluripotency regulators, including the transcription factor Nanog, are observed to fluctuate stochastically in individual embryonic stem cells. By transiently priming cells for commitment to different lineages, these fluctuations are thought to be important to the maintenance of, and exit from, pluripotency. However, because temporal changes in intracellular protein abundances cannot be measured directly in live cells, fluctuations are typically assessed using genetically engineered reporter cell lines that produce a fluorescent signal as a proxy for protein expression. Here, using a combination of mathematical modeling and experiment, we show that there are unforeseen ways in which widely used reporter strategies can systematically disturb the dynamics they are intended to monitor, sometimes giving profoundly misleading results. In the case of Nanog, we show how genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type. These findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  7. Handbook of Research on Creative Problem-Solving Skill Development in Higher Education

    DEFF Research Database (Denmark)

    -solving. This has prompted institutions of higher education to implement new pedagogical methods such as problem-based and case-based education. The Handbook of Research on Creative Problem-Solving Skill Development in Higher Education is an essential, comprehensive collection of the newest research in higher...... education, creativity, problem solving, and pedagogical design. It provides the framework for further research opportunities in these dynamic, necessary fields. Featuring work regarding problem-oriented curriculum and its applications and challenges, this book is essential for policy makers, teachers......Developing students’ creative problem-solving skills is paramount to today’s teachers, due to the exponentially growing demand for cognitive plasticity and critical thinking in the workforce. In today’s knowledge economy, workers must be able to participate in creative dialogue and complex problem...

  8. Ground Zero in the Debate over Stem-Cell Research.

    Science.gov (United States)

    Southwick, Ron

    2001-01-01

    Describes how political, legal, and ethical battles over embryonic stem-cell research are focused on the University of Wisconsin at Madison, where the cells were first isolated. Addresses the issue of access to the university's stem cells and a recent presidential decision regarding funding for stem-cell research.(EV)

  9. Ethical problems inherent in psychological research based on internet communication as stored information

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter; Dyhrberg, Johan

    2007-01-01

    This paper deals with certain ethical problems inherent in psychological research based on internet communication as stored information. Section 1 contains an analysis of research on Internet debates. In particular, it takes into account a famous example of deception for psychology research...... purposes. In section 2, the focus is on research on personal data in texts published on the Internet. Section 3 includes an attempt to formulate some ethical principles and guidelines, which should be regarded as fundamental in research on stored information....

  10. RESEARCH PROBLEM DESCRIPTION AND DEFINITION: FROM MENTAL MAP TO CONNECTION CIRCLE

    Directory of Open Access Journals (Sweden)

    Mildeová, Stanislava

    2013-12-01

    Full Text Available The paper examines the research problem (question as one of the first methodological steps that has to be accurately and clearly defined. The necessity of modern scientific work is to understand and analyse problems holistically, to see it as a network of interconnected parts. In this sense we show that combination of mental mapping and connection circle may be a way that will be beneficial defining the research problem. There is some evidence from interviews held with PhD students, who were participated in the course Research Methods for Managers at the University of Economics in Prague from 2012-2013.

  11. Key Problems in Organizing and Structuring University Research in Vietnam: The Lack of an Effective Research "Behaviour Formalization" System

    Science.gov (United States)

    Nguyen, Huong Thi Lan; Meek, Vincent Lynn

    2016-01-01

    Structure and organization seems to be at the root of many of the questions raised about institutional behaviour; however, with respect to research on university capacity building, few studies have examined research organizational problems, particularly in developing countries. This study investigates academic reactions to the structure and…

  12. Alaska communities and forest environments: a problem analysis and research agenda.

    Science.gov (United States)

    Linda E. Kruger; Rhonda L. Mazza

    2006-01-01

    This problem analysis describes a variety of human-resource interaction issues and identifies related social science research and development needs that serve as the foundation for the Alaska Communities and Forest Environments Team within the Pacific Northwest Research Station. The document lays out a research agenda that focuses on understanding relations between...

  13. Recent Research Trends in Genetic Algorithm Based Flexible Job Shop Scheduling Problems

    Directory of Open Access Journals (Sweden)

    Muhammad Kamal Amjad

    2018-01-01

    Full Text Available Flexible Job Shop Scheduling Problem (FJSSP is an extension of the classical Job Shop Scheduling Problem (JSSP. The FJSSP is known to be NP-hard problem with regard to optimization and it is very difficult to find reasonably accurate solutions of the problem instances in a rational time. Extensive research has been carried out in this area especially over the span of the last 20 years in which the hybrid approaches involving Genetic Algorithm (GA have gained the most popularity. Keeping in view this aspect, this article presents a comprehensive literature review of the FJSSPs solved using the GA. The survey is further extended by the inclusion of the hybrid GA (hGA techniques used in the solution of the problem. This review will give readers an insight into use of certain parameters in their future research along with future research directions.

  14. Requirements Engineering as Creative Problem Solving: A Research Agenda for Idea Finding

    OpenAIRE

    Maiden, N.; Jones, S.; Karlsen, I. K.; Neill, R.; Zachos, K.; Milne, A.

    2010-01-01

    This vision paper frames requirements engineering as a creative problem solving process. Its purpose is to enable requirements researchers and practitioners to recruit relevant theories, models, techniques and tools from creative problem solving to understand and support requirements processes more effectively. It uses 4 drivers to motivate the case for requirements engineering as a creative problem solving process. It then maps established requirements activities onto one of the longest-esta...

  15. Radiolabeled red blood cells: status, problems, and prospects

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, S.C.

    1983-01-01

    Radionuclidic labels for red cells can be divided into two main categories - cohort or pulse labels, and random labels. The random labels are incorporated into circulating cells of all ages and the labeling process is usually carried out in vitro. The red cell labels in predominant use involve random labeling and employ technetium-99m, chromium-51, indium-111, and gallium-68, roughly in that order. The extent of usefulness depends on the properties of the label such as the half-life, decay mode, and in-vivo stability, etc. Labeled cells can be used for red cell survival measurements when the half-life of the radionuclide is sufficiently long. The major portion of this article deals with random labels.

  16. Radiolabeled red blood cells: status, problems, and prospects

    International Nuclear Information System (INIS)

    Srivastava, S.C.

    1983-01-01

    Radionuclidic labels for red cells can be divided into two main categories - cohort or pulse labels, and random labels. The random labels are incorporated into circulating cells of all ages and the labeling process is usually carried out in vitro. The red cell labels in predominant use involve random labeling and employ technetium-99m, chromium-51, indium-111, and gallium-68, roughly in that order. The extent of usefulness depends on the properties of the label such as the half-life, decay mode, and in-vivo stability, etc. Labeled cells can be used for red cell survival measurements when the half-life of the radionuclide is sufficiently long. The major portion of this article deals with random labels

  17. Impact of problem finding on the quality of authentic open inquiry science research projects

    Science.gov (United States)

    Labanca, Frank

    2008-11-01

    Problem finding is a creative process whereby individuals develop original ideas for study. Secondary science students who successfully participate in authentic, novel, open inquiry studies must engage in problem finding to determine viable and suitable topics. This study examined problem finding strategies employed by students who successfully completed and presented the results of their open inquiry research at the 2007 Connecticut Science Fair and the 2007 International Science and Engineering Fair. A multicase qualitative study was framed through the lenses of creativity, inquiry strategies, and situated cognition learning theory. Data were triangulated by methods (interviews, document analysis, surveys) and sources (students, teachers, mentors, fair directors, documents). The data demonstrated that the quality of student projects was directly impacted by the quality of their problem finding. Effective problem finding was a result of students using resources from previous, specialized experiences. They had a positive self-concept and a temperament for both the creative and logical perspectives of science research. Successful problem finding was derived from an idiosyncratic, nonlinear, and flexible use and understanding of inquiry. Finally, problem finding was influenced and assisted by the community of practicing scientists, with whom the students had an exceptional ability to communicate effectively. As a result, there appears to be a juxtaposition of creative and logical/analytical thought for open inquiry that may not be present in other forms of inquiry. Instructional strategies are suggested for teachers of science research students to improve the quality of problem finding for their students and their subsequent research projects.

  18. Research Utilizing Problem Solving (RUPS) - Classroom Version. Description of Teacher Inservice Education Materials.

    Science.gov (United States)

    National Education Association, Washington, DC. Project on Utilization of Inservice Education R & D Outcomes.

    The workshop instructional materials described here are designed to try out a systematic problem solving process as a way of working toward improvements in the school setting. Topics include diagnosis using force field technique, small group dynamics, planning for action, and planning a RUPS (Research Using Problem Solving) project. This…

  19. The Legacy of Hobbs and Gray: Research on the Development and Prevention of Conduct Problems.

    Science.gov (United States)

    Dodge, Kenneth A.

    1996-01-01

    Describes research on the development of chronic conduct problems in childhood and adolescence, examining a multiple risk-factor model that includes biological predispositions, ecological context, family processes, peer influences, academic performance, and social information processing as factors leading to conduct problems. The paper describes a…

  20. Triage: Making a Political Decision to Solve an Environmental Science Problem Through Research

    Science.gov (United States)

    Ridolfi, Thomas

    1974-01-01

    A description is given of a class project concerned with examining a population problem and making some political decisions to solve it. A list of topics for the students to research as a basis for their decisions is provided. (DT)

  1. Assistant professor Andrea Wittenborn, research team conduct clinical trial to treat couples' depression, marital problems

    OpenAIRE

    Micale, Barbara L.

    2010-01-01

    Andrea Wittenborn, assistant professor, human development, is heading a research team conducting the Strengthening Bonds Couples Therapy Study to treat depression and marital problems (dyadic distress) in married/committed couple relationships.

  2. Competitive Benchmarking: An IS Research Approach to Address Wicked Problems with Big Data and Analytics

    NARCIS (Netherlands)

    W. Ketter (Wolfgang); M. Peters (Markus); J. Collins (John); A. Gupta (Alok)

    2015-01-01

    textabstractWicked problems like sustainable energy and financial market stability are societal challenges that arise from complex socio-technical systems in which numerous social, economic, political, and technical factors interact. Understanding and mitigating them requires research methods that

  3. Qualitative Research? Quantitative Research? What's the Problem? Resolving the Dilemma via a Postconstructivist Approach.

    Science.gov (United States)

    Shank, Gary

    It is argued that the debate between qualitative and quantitative research for educational researchers is actually an argument between constructivism and positivism. Positivism has been the basis for most quantitative research in education. Two different things are actually meant when constructivism is discussed (constructivism and…

  4. Estimating Rates of Psychosocial Problems in Urban and Poor Children with Sickle Cell Anemia.

    Science.gov (United States)

    Barbarin, Oscar A.; And Others

    1994-01-01

    Examined adjustment problems for children and adolescents with sickle cell anemia (SCA). Parents provided information on social, emotional, academic, and family adjustment of 327 children with SCA. Over 25% of children had emotional adjustment problems in form of internalizing symptoms (anxiety and depression); at least 20% had problems related to…

  5. Internet research: an opportunity to revisit classic ethical problems in behavioral research.

    Science.gov (United States)

    Pittenger, David J

    2003-01-01

    The Internet offers many new opportunities for behavioral researchers to conduct quantitative and qualitative research. Although the ethical guidelines of the American Psychological Association generalize, in part, to research conducted through the Internet, several matters related to Internet research require further analysis. This article reviews several fundamental ethical issues related to Internet research, namely the preservation of privacy, the issuance of informed consent, the use of deception and false feedback, and research methods. In essence, the Internet offers unique challenges to behavioral researchers. Among these are the need to better define the distinction between private and public behavior performed through the Internet, ensure mechanisms for obtaining valid informed consent from participants and performing debriefing exercises, and verify the validity of data collected through the Internet.

  6. College Students' Conceptions of Stem Cells, Stem Cell Research, and Cloning

    Science.gov (United States)

    Concannon, James P.; Siegel, Marcelle A.; Halverson, Kristy; Freyermuth, Sharyn

    2010-01-01

    In this study, we examined 96 undergraduate non-science majors' conceptions of stem cells, stem cell research, and cloning. This study was performed at a large, Midwest, research extensive university. Participants in the study were asked to answer 23 questions relating to stem cells, stem cell research, and cloning in an on-line assessment before…

  7. Means-end chains and laddering: An inventory of problems and an agenda for research

    DEFF Research Database (Denmark)

    Grunert, Klaus G.; Beckmann, Suzanne C.; Sørensen, Elin

    2001-01-01

    and unconscious (or, at least, semiconscious) factors. It is intuitively appealing to the practitioner but has, likewise, attracted academic research. Increased acceptance and use of a new approach inevitably leads to the detection of unresolved issues and problems. Many of these unresolved issues are related...... to the collection and analysis of laddering data. However, many of these also point at problems of a more theoretical nature. In this chapter presented are some of the issues regarded as unresolved and suggested research that could help in solving these problems. The mayor part of this chapter deals...... with methodological problems of the interview technique called laddering, og coding laddering data, and of analysing the coded data. However, also shown, methodological and theoretical issues are partly interlinked: resolutions of methodological problems may require theoretical progress or at least a clarification...

  8. Attitude of A Sample of Iranian Researchers toward The Future of Stem Cell Research.

    Science.gov (United States)

    Lotfipanah, Mahdi; Azadeh, Fereydoon; Totonchi, Mehdi; Omani-Samani, Reza

    2018-10-01

    Stem cells that have unlimited proliferation potential as well as differentiation potency are considered to be a promising future treatment method for incurable diseases. The aim of the present study is to evaluate the future trend of stem cell researches from researchers' viewpoints. This was a cross-sectional descriptive study on researchers involved in stem cell research at Royan Institute. We designed a questionnaire using a qualitative study based on expert opinion and a literature review. Content validity was performed using three rounds of the Delphi method with experts. Face validity was undertaken by a Persian literature expert and a graphics designer. The questionnaire was distributed among 150 researchers involved in stem cell studies in Royan Institute biology laboratories. We collected 138 completed questionnaires. The mean age of participants was 31.13 ± 5.8 years; most (60.9%) were females. Participants (76.1%) considered the budget to be the most important issue in stem cell research, 79.7% needed financial support from the government, and 77.5% felt that charities could contribute substantially to stem cell research. A total of 90.6% of participants stated that stem cells should lead to commercial usage which could support future researches (86.2%). The aim of stem cell research was stipulated as increasing health status of the society according to 92.8% of the participants. At present, among cell types, importance was attached to cord blood and adult stem cells. Researchers emphasized the importance of mesenchymal stem cells (MSCs) rather than hematopoietic stem cells (HSCs, 57.73%). The prime priorities were given to cancer so that stem cell research could be directed to sphere stem cell research whereas the least preference was given to skin research. Regenerative medicine is considered the future of stem cell research with emphasis on application of these cells, especially in cancer treatment. Copyright© by Royan Institute. All rights

  9. Modeling PSA Problems - II: A Cell-to-Cell Transport Theory Approach

    International Nuclear Information System (INIS)

    Labeau, P.E.; Izquierdo, J.M.

    2005-01-01

    In the first paper of this series, we presented an extension of the classical theory of dynamic reliability in which the actual occurrence of an event causing a change in the system dynamics is possibly delayed. The concept of stimulus activation, which triggers the realization of an event after a distributed time delay, was introduced. This gives a new understanding of competing events in the sequence delineation process.In the context of the level-2 probabilistic safety analysis (PSA), the information on stimulus activation mainly consists of regions of the process variables space where the activation can occur with a given probability. The evolution equations of the extended theory of probabilistic dynamics are therefore particularized to a transport process between discrete cells defined in phase-space on this basis. Doing so, an integrated and coherent approach to level-2 PSA problems is propounded. This amounts to including the stimulus concept and the associated stochastic delays discussed in the first paper in the frame of a cell-to-cell transport process.In addition, this discrete model provides a theoretical basis for the definition of appropriate numerical schemes for integrated level-2 PSA applications

  10. The cell method for electrical engineering and multiphysics problems an introduction

    CERN Document Server

    Alotto, Piergiorgio; Repetto, Maurizio; Rosso, Carlo

    2013-01-01

    This book presents a numerical scheme for the solution of field problems governed by partial differential equations: the cell method. The technique lends itself naturally to the solution of multiphysics problems with several interacting phenomena. The Cell Method, based on a space-time tessellation, is intimately related to the work of Tonti and to his ideas of classification diagrams or, as they are nowadays called, Tonti diagrams: a graphical representation of the problem's equations made possible by a suitable selection of a space-time framework relating physical variables to each other. The main features of the cell method are presented and links with many other discrete numerical methods (finite integration techniques, finite difference time domain, finite volumes, mimetic finite differences, etc.) are discussed. After outlining the theoretical basis of the method, a set of physical problems which have been solved with the cell method is described. These single and multiphysics problems stem from the aut...

  11. New paradigms for old problems: some (small) advances in laser resonator research at the CSIR

    Science.gov (United States)

    Forbes, Andrew

    2010-02-01

    In this paper we outline new approaches to old problems, namely understanding the transverse modes in Porro prism resonators, and creating methods to select Gaussian beams by phase-only intra-cavity elements. In the process we outline some of the recent research that has taken place within the Mathematical Optics research group.

  12. Scientific Paradigms and Falsification: Kuhn, Popper, and Problems in Education Research

    Science.gov (United States)

    Hyslop-Margison, Emery James

    2010-01-01

    By examining the respective contributions of Karl Popper and Thomas Kuhn to the philosophy of science, the author highlights some prevailing problems in this article with the methods of so-called scientific research in education. The author enumerates a number of reasons why such research, in spite of its limited tangible return, continues to gain…

  13. Mixed-Method Nursing Research: "A Public and Its Problems?" A Commentary on French Nursing Research.

    Science.gov (United States)

    Dupin, Cécile Marie; Debout, Christophe; Rothan-Tondeur, Monique

    2014-02-01

    Nursing in France is undergoing a transition. In 2009, the preregistration nursing education program was reformed in line with the European Bologna Process, bringing nursing education to the universities. In 2010, the French Programme Hospitalier de Recherche Infirmière, the first national French nursing research funding program, was launched by the French Health Ministry. Of the 149 French research proposals submitted by registered nurses in 2010 and 2011, 13 were mixed-method proposals. The registered nurse principal investigator argued for a complementary use of qualitative and quantitative methods. These trends highlight major issues regarding mixed-method and nursing research. We can reasonably assume that mixed-method research has a broad appeal for nurse scholars, particularly for the exploration of complex phenomena related to nursing. Moreover, the recent movement in the domain of nursing education and research experienced in France highlights the need for dedicated research education in the development of nursing research capacity. © The Author(s) 2014 Reprints and permissions:]br]sagepub.co.uk/journalsPermissions.nav.

  14. The use of radiochemical techniques in fuel cell research

    International Nuclear Information System (INIS)

    Meier, H.

    1975-01-01

    The utilization of metal chelates as catalysts in fuel cell research gives rise to special problems which cannot be solved by the usual methods, but may be well clarified by isotope technical methods. The electrocatalytic efficiency of polymer iron phthalocyanine (on carbon carriers) can be proved by the plotting of potential-current density curves. Two questions, however, remain unanswered: a) What is the solubility behaviour of the catalyst, and b) is there an additional stabilizing interaction between the metal chelate catalyst and the carbon electrode. To answer the first question, the iron phthalocyanine was labelled with Fe-59 and the dissolving time of the complexed Fe ions measured; the results were compared with the potential time behaviour of the oxygen cathodes. To check the interactions between phthalocyamine catalysts and carbon carrier, Moessbauer spectroscopy was used. The evidence obtained suggest the application of isotope technical methods to an ever greater extent than up to now in fuel cell and battery research. (RB/LH) [de

  15. Sickle cell disease in Sierra Leone: a neglected problem | Roberts ...

    African Journals Online (AJOL)

    Eleven (2.4%) were Sickle Cell-HbC disease, median age 14 years. Patients demonstrated many of the typical features of SCD. The most common reason for hospital admission was bone pain crisis associated with an infection, followed by severe anemia. Aseptic necrosis of the femoral head, leg ulcers, septic osteomyelitis ...

  16. Guidelines for the use of cell lines in biomedical research.

    Science.gov (United States)

    Geraghty, R J; Capes-Davis, A; Davis, J M; Downward, J; Freshney, R I; Knezevic, I; Lovell-Badge, R; Masters, J R W; Meredith, J; Stacey, G N; Thraves, P; Vias, M

    2014-09-09

    Cell-line misidentification and contamination with microorganisms, such as mycoplasma, together with instability, both genetic and phenotypic, are among the problems that continue to affect cell culture. Many of these problems are avoidable with the necessary foresight, and these Guidelines have been prepared to provide those new to the field and others engaged in teaching and instruction with the information necessary to increase their awareness of the problems and to enable them to deal with them effectively. The Guidelines cover areas such as development, acquisition, authentication, cryopreservation, transfer of cell lines between laboratories, microbial contamination, characterisation, instability and misidentification. Advice is also given on complying with current legal and ethical requirements when deriving cell lines from human and animal tissues, the selection and maintenance of equipment and how to deal with problems that may arise.

  17. A facility for using cluster research to study environmental problems. Workshop proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This report begins by describing the general application of cluster based research to environmental chemistry and the development of a Cluster Structure and Dynamics Research Facility (CSDRF). Next, four important areas of cluster research are described in more detail, including how they can impact environmental problems. These are: surface-supported clusters, water and contaminant interactions, time-resolved dynamic studies in clusters, and cluster structures and reactions. These facilities and equipment required for each area of research are then presented. The appendices contain workshop agenda and a listing of the researchers who participated in the workshop discussions that led to this report.

  18. Quality of life of people with mental health problems: a synthesis of qualitative research

    OpenAIRE

    Connell, Janice; Brazier, John; O?Cathain, Alicia; Lloyd-Jones, Myfanwy; Paisley, Suzy

    2012-01-01

    Abstract Purpose To identify the domains of quality of life important to people with mental health problems. Method A systematic review of qualitative research undertaken with people with mental health problems using a framework synthesis. Results We identified six domains: well-being and ill-being; control, autonomy and choice; self-perception; belonging; activity; and hope and hopelessness. Firstly, symptoms or ‘ill-being’ were an intrinsic aspect of quality of life for people with severe m...

  19. Sourcing human embryos for embryonic stem cell lines: Problems & perspectives

    Directory of Open Access Journals (Sweden)

    Rajvi H Mehta

    2014-01-01

    Full Text Available The ability to successfully derive human embryonic stem cells (hESC lines from human embryos following in vitro fertilization (IVF opened up a plethora of potential applications of this technique. These cell lines could have been successfully used to increase our understanding of human developmental biology, transplantation medicine and the emerging science of regenerative medicine. The main source for human embryos has been ′discarded′ or ′spare′ fresh or frozen human embryos following IVF. It is a common practice to stimulate the ovaries of women undergoing any of the assisted reproductive technologies (ART and retrieve multiple oocytes which subsequently lead to multiple embryos. Of these, only two or maximum of three embryos are transferred while the rest are cryopreserved as per the decision of the couple. In case a couple does not desire to ′cryopreserve′ their embryos then all the embryos remaining following embryo transfer can be considered ′spare′ or if a couple is no longer in need of the ′cryopreserved′ embryos then these also can be considered as ′spare′. But, the question raised by the ethicists is, "what about ′slightly′ over-stimulating a woman to get a few extra eggs and embryos? The decision becomes more difficult when it comes to ′discarded′ embryos. As of today, the quality of the embryos is primarily assessed based on morphology and the rate of development mainly judged by single point assessment. Despite many criteria described in the literature, the quality assessment is purely subjective. The question that arises is on the decision of ′discarding′ embryos. What would be the criteria for discarding embryos and the potential ′use′ of ESC derived from the ′abnormal appearing′ embryos? This paper discusses some of the newer methods to procure embryos for the derivation of embryonic stem cell lines which will respect the ethical concerns but still provide the source material.

  20. Systemic Problems: A perspective on stem cell aging and rejuvenation.

    Science.gov (United States)

    Conboy, Irina M; Conboy, Michael J; Rebo, Justin

    2015-10-01

    This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.

  1. Adjacent-cell Preconditioners for solving optically thick neutron transport problems

    International Nuclear Information System (INIS)

    Azmy, Y.Y.

    1994-01-01

    We develop, analyze, and test a new acceleration scheme for neutron transport methods, the Adjacent-cell Preconditioner (AP) that is particularly suited for solving optically thick problems. Our method goes beyond Diffusion Synthetic Acceleration (DSA) methods in that it's spectral radius vanishes with increasing cell thickness. In particular, for the ID case the AP method converges immediately, i.e. in one iteration, to 10 -4 pointwise relative criterion in problems with dominant cell size of 10 mfp or thicker. Also the AP has a simple formalism and is cell-centered hence, multidimensional and high order extensions are easier to develop, and more efficient to implement

  2. Intermodal safety research needs report of the sixth workshop on national transportation problems

    Energy Technology Data Exchange (ETDEWEB)

    Warshawer, A.J. (ed.)

    1976-04-01

    This conference brought together DOT policymakers, university principal investigators and other professionals to consider the intermodal safety research requirements of the Department of Transportation. The objectives of the conference were: (1) to highlight safety problems and needed transportation safety research identified by DOT modal safety managers and to stimulate university or university/industry teams to respond with research proposals which emphasize multi-modal applicability and a system view; and (2) to provide a forum for university research groups to inform DOT safety managers of promising new directions in transportation safety research and new tools with which to address safety related problems. The conference addressed the research requirements for safety as identified by the Statement of National Transportation Policy and by the modal safety managers in three principal contexts, each a workshop panel: I, Inter-Institutional Problems of Transportation Safety. Problems were described as: Federal-State, local; Federal-Industry; Federal-Public, Consumer groups. II, Goal Setting and Planning for Transportation Safety Programs. Issues were: modifying risk behavior, safety as a social value, and involving citizens in development of standards as a way of increasing probability of achieving program objectives. III, DOT Information, Management, and Evaluation Systems Requirements. Needs were: data requirements and analytic tools for management of safety programs.

  3. FTA fuel cell bus program : research accomplishments through 2011.

    Science.gov (United States)

    2012-03-01

    Prepared by the Federal Transit Administration (FTA) Office of Research, Demonstration, and Innovation (TRI), this report summarizes the accomplishments of fuel-cell-transit-bus-related research and demonstrations projects supported by FTA through 20...

  4. Electrocatalysis research for fuel cells and hydrogen production

    CSIR Research Space (South Africa)

    Mathe, MK

    2012-01-01

    Full Text Available The CSIR undertakes research in the Electrocatalysis of fuel cells and for hydrogen production. The Hydrogen South Africa (HySA) strategy supports research on electrocatalysts due to their importance to the national beneficiation strategy. The work...

  5. Scientists' perspectives on the ethical issues of stem cell research.

    Science.gov (United States)

    Longstaff, Holly; Schuppli, Catherine A; Preto, Nina; Lafrenière, Darquise; McDonald, Michael

    2009-06-01

    This paper describes findings from an ethics education project funded by the Canadian Stem Cell Network (SCN). The project is part of a larger research initiative entitled "The Stem Cell Research Environment: Drawing the Evidence and Experience Together". The ethics education study began with a series of focus groups with SCN researchers and trainees as part of a "needs assessment" effort. The purpose of these discussions was to identify the main ethical issues associated with stem cell (SC) research from the perspective of the stem cell community. This paper will focus on five prominent themes that emerged from the focus group data including: (1) the source of stem cells; (2) the power of stem cells; (3) working within a charged research environment; (4) the regulatory context; and (5) ethics training for scientists. Additional discussions are planned with others involved in Canadian stem cell research (e.g., research ethics board members, policy makers) to supplement initial findings. These assessment results combined with existing bioethics literature will ultimately inform a web-based ethics education module for the SCN. We believe that our efforts are important for those analyzing the ethical, legal, and social issues (ELSI) in this area because our in depth understanding of stem cell researcher perspectives will enable us to develop more relevant and effective education material, which in turn should help SC researchers address the important ethical challenges in their area.

  6. Mexico City air quality research initiative. Volume 2, Problem definition, background, and summary of prior research

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    Air pollution in Mexico City has increased along with the growth of the city, the movement of its population, and the growth of employment created by industry. The main cause of pollution in the city is energy consumption. Therefore, it is necessary to take into account the city`s economic development and its prospects when considering the technological relationships between well-being and energy consumption. Air pollution in the city from dust and other particles suspended in the air is an old problem. However, pollution as we know it today began about 50 years ago with the growth of industry, transportation, and population. The level of well-being attained in Mexico City implies a high energy use that necessarily affects the valley`s natural air quality. However, the pollution has grown so fast that the City must act urgently on three fronts: first, following a comprehensive strategy, transform the economic foundation of the city with nonpolluting activities to replace the old industries, second, halt pollution growth through the development of better technologies; and third, use better fuels, emission controls, and protection of wooded areas.

  7. Stem cell research in pakistan; past, present and future.

    Science.gov (United States)

    Zahra, Sayeda Anum; Muzavir, Sayed Raheel; Ashraf, Sadia; Ahmad, Aftab

    2015-05-01

    Stem cells have proved to have great therapeutic potential as stem cell treatment is replacing traditional ways of treatment in different disorders like cancer, aplastic anemia, stroke, heart disorders. The developed and developing countries are investing differently in this area of research so research output and clinical translation of research greatly vary among developed and developing countries. Present study was done to investigate the current status of stem cells research in Pakistan and ways to improve it. Many advanced countries (USA, UK and Canada etc.) are investing heavily in stem cell research and treatment. Different developing countries like Iran, Turkey and India are also following the developed countries and investing a lot in stem cells research. Pakistan is also making efforts in establishing this field to get desired benefits but unfortunately the progress is at very low pace. If Government plays an active role along with private sector, stem cell research in Pakistan can be boosted up. The numbers of publications from Pakistan are very less compared to developed and neighboring countries and Pakistan also has very less number of institutes working in this area of research. Stem cells research is at its initial stages in Pakistan and there is great need to bring Government, academia and industry together so they could make serious efforts to promote research in this very important field. This will help millions of patients suffering from incurable disorders and will also reduce economic loss.

  8. Analytical solution and experimental validation of the energy management problem for fuel cell hybrid vehicles

    NARCIS (Netherlands)

    P.P.J. van den Bosch; Edwin Tazelaar; M. Grimminck; Stijn Hoppenbrouwers; Bram Veenhuizen

    2011-01-01

    The objective of an energy management strategy for fuel cell hybrid propulsion systems is to minimize the fuel needed to provide the required power demand. This minimization is defined as an optimization problem. Methods such as dynamic programming numerically solve this optimization problem.

  9. The role of nanotechnology in induced pluripotent and embryonic stem cells research.

    Science.gov (United States)

    Chen, Lukui; Qiu, Rong; Li, Lushen

    2014-12-01

    This paper reviews the recent studies on development of nanotechnology in the field of induced pluripotent and embryonic stem cells. Stem cell therapy is a promising therapy that can improve the quality of life for patients with refractory diseases. However, this option is limited by the scarcity of tissues, ethical problem, and tumorigenicity. Nanotechnology is another promising therapy that can be used to mimic the extracellular matrix, label the implanted cells, and also can be applied in the tissue engineering. In this review, we briefly introduce implementation of nanotechnology in induced pluripotent and embryonic stem cells research. Finally, the potential application of nanotechnology in tissue engineering and regenerative medicine is also discussed.

  10. Ethical and regulatory aspects of embryonic stem cell research.

    Science.gov (United States)

    Jain, Kewal K

    2002-12-01

    Ethical and regulatory issues concerning embryonic stem (ES) cell research are reviewed here a year after the controversy became a public and political issue in the US. The background of various issues are examined and the current regulations in various countries are reviewed. In the US, the debate is linked with abortion, as well as the status of a fetus as a human being, and is politically driven. Obtaining stem cells from embryonic tissues involves destruction of the embryo, to which objections are raised. Religious beliefs are examined and no serious impediments to ES cell research could be identified. Regulations vary from one country to another and it is unlikely that there will ever be any universally uniform ethical and regulatory standards for ES cell research. Currently, the most liberal and favourable environments for ES cell research are in the UK, Singapore, Sweden, India, Israel and China. Unless the US liberalises ES cell research, it may lose its lead in ES cell research and investments in this area may drift to countries with better environments for research. Suggestions are offered in this review to improve the ethical environment for ES cell research.

  11. Potential high efficiency solar cells: Applications from space photovoltaic research

    Science.gov (United States)

    Flood, D. J.

    1986-01-01

    NASA involvement in photovoltaic energy conversion research development and applications spans over two decades of continuous progress. Solar cell research and development programs conducted by the Lewis Research Center's Photovoltaic Branch have produced a sound technology base not only for the space program, but for terrestrial applications as well. The fundamental goals which have guided the NASA photovoltaic program are to improve the efficiency and lifetime, and to reduce the mass and cost of photovoltaic energy conversion devices and arrays for use in space. The major efforts in the current Lewis program are on high efficiency, single crystal GaAs planar and concentrator cells, radiation hard InP cells, and superlattice solar cells. A brief historical perspective of accomplishments in high efficiency space solar cells will be given, and current work in all of the above categories will be described. The applicability of space cell research and technology to terrestrial photovoltaics will be discussed.

  12. MULTICRITERIA HYBRID FLOW SHOP SCHEDULING PROBLEM: LITERATURE REVIEW, ANALYSIS, AND FUTURE RESEARCH

    Directory of Open Access Journals (Sweden)

    Marcia de Fatima Morais

    2014-12-01

    Full Text Available This research focuses on the Hybrid Flow Shop production scheduling problem, which is one of the most difficult problems to solve. The literature points to several studies that focus the Hybrid Flow Shop scheduling problem with monocriteria functions. Despite of the fact that, many real world problems involve several objective functions, they can often compete and conflict, leading researchers to concentrate direct their efforts on the development of methods that take consider this variant into consideration. The goal of the study is to review and analyze the methods in order to solve the Hybrid Flow Shop production scheduling problem with multicriteria functions in the literature. The analyses were performed using several papers that have been published over the years, also the parallel machines types, the approach used to develop solution methods, the type of method develop, the objective function, the performance criterion adopted, and the additional constraints considered. The results of the reviewing and analysis of 46 papers showed opportunities for future research on this topic, including the following: (i use uniform and dedicated parallel machines, (ii use exact and metaheuristics approaches, (iv develop lower and uppers bounds, relations of dominance and different search strategies to improve the computational time of the exact methods,  (v develop  other types of metaheuristic, (vi work with anticipatory setups, and (vii add constraints faced by the production systems itself.

  13. Symposium Connects Government Problems with State of the Art Network Science Research

    Science.gov (United States)

    2015-10-16

    Symposium Connects Government Problems with State-of-the- Art Network Science Research By Rajmonda S. Caceres and Benjamin A. Miller Network...the US Gov- ernment, and match these with the state-of-the- art models and techniques developed in the network science research community. Since its... science has grown significantly in the last several years as a field at the intersec- tion of mathematics, computer science , social science , and engineering

  14. Research problems and trends of the pharmaceutical market Sudan as social oriented structure of the country

    OpenAIRE

    Олена Миколаївна Євтушенко; Осама Абузаїд Мохамед Нур Ахмед

    2016-01-01

    Aim: The research object was the definition of problems and tendencies of pharmaceutical market development of Sudan as the country which in recent years tries to pull through the consequence of political and economic crisis and to build the socially oriented model of the state.Methods: In the researches it has been used the marketing and economic analysis methods as well as the historical, logical, comparative and graphic methods.Results: The authors represented the marketing analysis result...

  15. Research Paper: Effectiveness of Social Skills Training on Behavioral Problems in Adolescents with Intellectual Disability

    Directory of Open Access Journals (Sweden)

    Abbas Nesayan

    2016-07-01

    Conclusion This research showed that social skills training were not significantly effective on behavioral problems in adolescents with intellectual disability. Although our results were not effective, research evidence shows that people with cognitive delays (such as intellectual disability require social skill training programs that include all of their academic, career, daily life, and social skills. As social skills learning plays a role in personal and social adjustment, it is necessary to pay more attention to these skills.

  16. Maternal cell phone use during pregnancy and child behavioral problems in five birth cohorts

    NARCIS (Netherlands)

    Birks, Laura; Guxens, Mònica; Papadopoulou, Eleni; Alexander, Jan; Ballester, Ferran; Estarlich, Marisa; Gallastegi, Mara; Ha, Mina; Haugen, Margaretha; Huss, Anke; Kheifets, Leeka; Lim, Hyungryul; Olsen, Jørn; Santa-Marina, Loreto; Sudan, Madhuri; Vermeulen, Roel; Vrijkotte, Tanja; Cardis, Elisabeth; Vrijheid, Martine

    2017-01-01

    Previous studies have reported associations between prenatal cell phone use and child behavioral problems, but findings have been inconsistent and based on retrospective assessment of cell phone use. This study aimed to assess this association in a multi-national analysis, using data from three

  17. Maternal cell phone use during pregnancy and child behavioral problems in five birth cohorts

    NARCIS (Netherlands)

    Birks, Laura; Guxens, Mònica; Papadopoulou, Eleni; Alexander, Jan; Ballester, Ferran; Estarlich, Marisa; Gallastegi, Mara; Ha, Mina; Haugen, Margaretha; Huss, Anke; Kheifets, Leeka; Lim, Hyungryul; Olsen, Jørn; Santa-Marina, Loreto; Sudan, Madhuri; Vermeulen, Roel; Vrijkotte, Tanja; Cardis, Elisabeth; Vrijheid, Martine

    INTRODUCTION: Previous studies have reported associations between prenatal cell phone use and child behavioral problems, but findings have been inconsistent and based on retrospective assessment of cell phone use. This study aimed to assess this association in a multi-national analysis, using data

  18. An Exploratory Research on Deviant Behaviors of Problem Patrons in Taiwan’s Public Library

    Directory of Open Access Journals (Sweden)

    Chen Su-May Sheih

    2016-11-01

    Full Text Available Patrons of public libraries are more diverse and complex than those of other types of libraries, implying potentially more unexpected and difficult situations. Negative emotions such as frustration and anxiety are generated among librarians when they must handle problem patrons, an effort that may influence the work efficiency of librarians and their physical and mental health. This study conducted a semi-structured in-depth interview, using public service librarians in Taiwan as subjects, to explore the categories of problem patrons and their behavioral characteristics. According to the results, the behavioral characteristics of problem patrons can be divided into 6 categories: interfering with others, violating library regulations, influencing library works, improperly using resources and facilities, breaking laws, and exhibiting a psychological disorder as well as violating social norms. On the basis of the research results, this study offers suggestions for future reference when public libraries must handle problem patrons.

  19. Study of a methodology of identifying important research problems by the PIRT process

    International Nuclear Information System (INIS)

    Aoki, Takayuki; Takagi, Toshiyuki; Urayama, Ryoichi; Komura, Ichiro; Furukawa, Takashi; Yusa, Noritaka

    2014-01-01

    In this paper, we propose a new methodology of identifying important research problems to be solved to improve the performance of some specific scientific technologies by the phenomena identification and ranking table (PIRT) process which has been used as a methodology for demonstrating the validity of the best estimate simulation codes in US Nuclear Regulatory Commission (USNRC) licensing of nuclear power plants. The new methodology makes it possible to identify important factors affecting the performance of the technologies from the viewpoint of the figure of merit and problems associated with them while it keeps the fundamental concepts of the original PIRT process. Also in this paper, we demonstrate the effectiveness of the new methodology by applying it to a task of extracting research problems for improving an inspection accuracy of ultrasonic testing or eddy current testing in the inspection of objects having cracks due to fatigue or stress corrosion cracking. (author)

  20. Using Analytics to Transform a Problem-Based Case Library: An Educational Design Research Approach

    Science.gov (United States)

    Schmidt, Matthew; Tawfik, Andrew A.

    2018-01-01

    This article describes the iterative design, development, and evaluation of a case-based learning environment focusing on an ill-structured sales management problem. We discuss our processes and situate them within the broader framework of educational design research. The learning environment evolved over the course of three design phases. A…

  1. Comorbidity of Anxiety and Conduct Problems in Children: Implications for Clinical Research and Practice

    Science.gov (United States)

    Cunningham, Natoshia Raishevich; Ollendick, Thomas H.

    2010-01-01

    Given the relative lack of research on the comorbidity of anxiety disorders (ADs) and conduct problems (oppositional defiant disorder, conduct disorder) in youth, we examine this comorbidity from both basic and applied perspectives. First, we review the concept of comorbidity and provide a framework for understanding issues pertaining to…

  2. Prevalence of Adolescent Problem Gambling: A Systematic Review of Recent Research.

    Science.gov (United States)

    Calado, Filipa; Alexandre, Joana; Griffiths, Mark D

    2017-06-01

    Previous research has shown that gambling is a popular activity among adolescents. Following a rapid expansion of legalized gambling opportunities and the emergence of new forms of gambling, many researchers have carried out studies on adolescent gambling and problem gambling. The present paper reviews studies that have been conducted worldwide since 2000, and then presents a more detailed picture of adolescent gambling research in Europe, by providing a country-by country analysis. After an extensive search on academic databases and following an exclusion process, 44 studies were identified. The findings showed that 0.2-12.3 % of youth meet criteria for problem gambling, notwithstanding differences among assessment instruments, cut-offs, and timeframes. However, despite this variability, several demographic characteristics were associated with adolescent gambling involvement and problem gambling. It is concluded that a small but significant minority of adolescents have gambling-related problems. Such findings will hopefully encourage more research into youth gambling to further understand the determinants of this phenomenon.

  3. Scaffolding the Science: Problem Based Strategies for Teaching Interdisciplinary Undergraduate Research Methods

    Science.gov (United States)

    Keebaugh, Alaine; Darrow, Lyndsey; Tan, David; Jamerson, Heather

    2009-01-01

    Previous research has highlighted the effectiveness of Problem-Based Learning (PBL) in multiple disciplinary settings, including medicine, teacher education, business, allied health, and the social sciences. Yet interdisciplinary educators have very little information about how to implement PBL in classrooms where multiple disciplines are…

  4. Research on the Problem of Spur Gear Teeth Contact in the Car Gear Box

    Directory of Open Access Journals (Sweden)

    Viktor Skrickij

    2011-04-01

    Full Text Available The article presents research on the problem of two gear contact in the car gearbox. Contact stiffness is evaluated for the whole period of mesh. Also, contact stresses are evaluated in the contact place. The presented method can be used for calculating spur gear.Article in Lithuanian

  5. Ten-Year Research Update Review: Psychiatric Problems in Children with Epilepsy

    Science.gov (United States)

    Plioplys, Sigita; Dunn, David W.; Caplan, Rochelle

    2007-01-01

    The research on epilepsy, a neuropsychiatric disorder characterized by seizures, psychopathology, cognitive, and linguistic problems among children in the age group of 0 to 18 years is reported. Early identification of children with epilepsy (CWE) and the development of multidisciplinary management strategies would advance relevant clinical…

  6. Report to NASA Committee on Aircraft Operating Problems Relative to Aviation Safety Engineering and Research Activities

    Science.gov (United States)

    1963-01-01

    The following report highlights some of the work accomplished by the Aviation Safety Engineering and Research Division of the Flight Safety Foundations since the last report to the NASA Committee on Aircraft Operating Problems on 22 May 1963. The information presented is in summary form. Additional details may be provided upon request of the reports themselves may be obtained from AvSER.

  7. stem cell research: applications in haematological conditions

    African Journals Online (AJOL)

    Dr. E. P. Gharoro

    chemotherapy and radiation. This has allowed HSCT to be conducted in older patients without the need for hospitalization. STEM CELL COLLECTION. Types of Donors. There are two major types of bone marrow transplantation namely;. Autologous and Allogenic transplantations. Autologous: Bone marrow transplantation.

  8. Biocatalysis and bacterial cells; problems and prospects for biohydrogen

    International Nuclear Information System (INIS)

    Hallenbeck, P.C.; Viger, J.-F.

    2000-01-01

    Biological hydrogen production, studied in a number of model and small-scale systems over the last twenty-five years, has been advanced as a potential technology for producing clean energy. However, the rates and efficiencies of hydrogen production by any system fall far short of economic feasibility at present. A number of different systems have been proposed and studied including direct biophotolytic processes and two stage systems. Direct biophotolytic processes, though inherently attractive, suffer from the perhaps insurmountable barriers of the oxygen sensitivity of the enzymes involved and intrinsic limitations in light conversion efficiencies. Fermentative processes, using either biomass obtained in a first stage light conversion process or perhaps more attractively, various waste streams, present an interesting yet largely unexplored avenue for the biological production of hydrogen. Much is presently known about the molecular biology and biochemistry of the hydrogen producing enzymes, reductant generating systems, and physiology of many hydrogen producing organisms. The potential of metabolic engineering for redirecting electron flux to hydrogen production is discussed. Some of the relevant details of hydrogen evolving systems are reviewed in the hopes of identifying potentially limiting factors and therefore indicating directions for future research aimed at increasing production rates and conversion efficiencies to economically feasible levels. (author)

  9. Scientist, Single Cell Analysis Facility | Center for Cancer Research

    Science.gov (United States)

    The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives.  The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI’s intramural Center for Cancer Research (CCR).  The dedicated units provide electron microscopy, protein characterization, protein expression, optical microscopy and nextGen sequencing. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR).  CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise. KEY ROLES AND RESPONSIBILITIES We are seeking a highly motivated Scientist II to join the newly established Single Cell Analysis Facility (SCAF) of the Center for Cancer Research (CCR) at NCI. The SCAF will house state of the art single cell sequencing technologies including 10xGenomics Chromium, BD Genomics Rhapsody, DEPPArray, and other emerging single cell technologies. The Scientist: Will interact with close to 200 laboratories within the CCR to design and carry out single cell experiments for cancer research Will work on single cell isolation/preparation from various tissues and cells and related NexGen sequencing library preparation Is expected to author publications in peer reviewed scientific journals

  10. Review of international solutions to NEACRP benchmark BWR lattice cell problems

    International Nuclear Information System (INIS)

    Halsall, M.J.

    1977-12-01

    This paper summarises international solutions to a set of BWR benchmark problems. The problems, posed as an activity sponsored by the Nuclear Energy Agency Committee on Reactor Physics, were as follows: 9-pin supercell with central burnable poison pin, mini-BWR with 4 pin-cells and water gaps and control rod cruciform, full 7 x 7 pin BWR lattice cell with differential U 235 enrichment, and full 8 x 8 pin BWR lattice cell with water-hole, Pu-loading, burnable poison, and homogenised cruciform control rod. Solutions have been contributed by Denmark, Japan, Sweden, Switzerland and the UK. (author)

  11. Solving problems in social-ecological systems: definition, practice and barriers of transdisciplinary research.

    Science.gov (United States)

    Angelstam, Per; Andersson, Kjell; Annerstedt, Matilda; Axelsson, Robert; Elbakidze, Marine; Garrido, Pablo; Grahn, Patrik; Jönsson, K Ingemar; Pedersen, Simen; Schlyter, Peter; Skärbäck, Erik; Smith, Mike; Stjernquist, Ingrid

    2013-03-01

    Translating policies about sustainable development as a social process and sustainability outcomes into the real world of social-ecological systems involves several challenges. Hence, research policies advocate improved innovative problem-solving capacity. One approach is transdisciplinary research that integrates research disciplines, as well as researchers and practitioners. Drawing upon 14 experiences of problem-solving, we used group modeling to map perceived barriers and bridges for researchers' and practitioners' joint knowledge production and learning towards transdisciplinary research. The analysis indicated that the transdisciplinary research process is influenced by (1) the amount of traditional disciplinary formal and informal control, (2) adaptation of project applications to fill the transdisciplinary research agenda, (3) stakeholder participation, and (4) functional team building/development based on self-reflection and experienced leadership. Focusing on implementation of green infrastructure policy as a common denominator for the delivery of ecosystem services and human well-being, we discuss how to diagnose social-ecological systems, and use knowledge production and collaborative learning as treatments.

  12. State and Perspectives of Research in Bulgaria: Problems and Weacknesses in Science Policy [In Bulgarian

    Directory of Open Access Journals (Sweden)

    B.V. Toshev

    2014-12-01

    Full Text Available The current status of the Bulgarian research sector is analyzed. There are alarming trends both in the system of higher education as well as in the research organizations; some of them are listed. The main problems and weaknesses of the educational and research policy in Bulgaria are under the critic. Phenomena as mcdonaldization of higher education, mass higher education, integration processes in science of XXth century, the transition from the normal to post-normal science, appearance and development of surrogate science, increasing the number of marginal scientific sources, are considered in details. The basic normative science documents are considered and their weak features are exhibited.

  13. Instruction texts and problems for the training and examination of selected personnel at research nuclear facilities

    International Nuclear Information System (INIS)

    Matejka, K.; Fleischhans, J.; Hejzlar, R.

    1994-01-01

    The publication comprises 6 separate brochures: (1) Selected chapters in reactor theory; (2) Experimental education methods; (3) Research and experimental reactors; (4.1) Technical description of the LVR-15 reactor; (4.2) Technical description of the LR-0 reactor; (4.3) Technical description of the VR-1 reactor; (5) Research reactor safety and operation; and (6) Database of problems for qualification examinations. Brochure No. 4 consists of 3 separate parts. The publication is intended for the training and examination of the following research reactor staff: reactor operator, shift engineer, control physicist, and start-up group head. (J.B.)

  14. Reflections on foreign language study for students with language learning problems: research, issues and challenges.

    Science.gov (United States)

    Ganschow, L; Sparks, R L

    2000-01-01

    The study of foreign language (FL) learning for individuals who have found learning to read and write in their first language extremely problematic has been an under-researched area throughout the world. Since the 1980s, Leonore Ganschow and Richard Sparks have conducted pioneering research into the nature of difficulties, why they are encountered and how they can be minimized. In this paper the authors trace the development of their research on foreign language difficulties for students with language learning problems. They provide a summary of their findings and suggest new questions and directions for the field.

  15. Maternal cell phone use during pregnancy and child behavioral problems in five birth cohorts.

    Science.gov (United States)

    Birks, Laura; Guxens, Mònica; Papadopoulou, Eleni; Alexander, Jan; Ballester, Ferran; Estarlich, Marisa; Gallastegi, Mara; Ha, Mina; Haugen, Margaretha; Huss, Anke; Kheifets, Leeka; Lim, Hyungryul; Olsen, Jørn; Santa-Marina, Loreto; Sudan, Madhuri; Vermeulen, Roel; Vrijkotte, Tanja; Cardis, Elisabeth; Vrijheid, Martine

    2017-07-01

    Previous studies have reported associations between prenatal cell phone use and child behavioral problems, but findings have been inconsistent and based on retrospective assessment of cell phone use. This study aimed to assess this association in a multi-national analysis, using data from three cohorts with prospective data on prenatal cell phone use, together with previously published data from two cohorts with retrospectively collected cell phone use data. We used individual participant data from 83,884 mother-child pairs in the five cohorts from Denmark (1996-2002), Korea (2006-2011), the Netherlands (2003-2004), Norway (2004-2008), and Spain (2003-2008). We categorized cell phone use into none, low, medium, and high, based on frequency of calls during pregnancy reported by the mothers. Child behavioral problems (reported by mothers using the Strengths and Difficulties Questionnaire or Child Behavior Checklist) were classified in the borderline/clinical and clinical ranges using validated cut-offs in children aged 5-7years. Cohort specific risk estimates were meta-analyzed. Overall, 38.8% of mothers, mostly from the Danish cohort, reported no cell phone use during pregnancy and these mothers were less likely to have a child with overall behavioral, hyperactivity/inattention or emotional problems. Evidence for a trend of increasing risk of child behavioral problems through the maternal cell phone use categories was observed for hyperactivity/inattention problems (OR for problems in the clinical range: 1.11, 95%CI 1.01, 1.22; 1.28, 95%CI 1.12, 1.48, among children of medium and high users, respectively). This association was fairly consistent across cohorts and between cohorts with retrospectively and prospectively collected cell phone use data. Maternal cell phone use during pregnancy may be associated with an increased risk for behavioral problems, particularly hyperactivity/inattention problems, in the offspring. The interpretation of these results is unclear

  16. Active and Healthy Ageing as a Wicked Problem: The Contribution of a Multidisciplinary Research University.

    Science.gov (United States)

    Riva, Giuseppe; Graffigna, Guendalina; Baitieri, Maddalena; Amato, Alessandra; Bonanomi, Maria Grazia; Valentini, Paolo; Castelli, Guido

    2014-01-01

    The quest for an active and healthy ageing can be considered a "wicked problem." It is a social and cultural problem, which is difficult to solve because of incomplete, changing, and contradictory requirements. These problems are tough to manage because of their social complexity. They are a group of linked problems embedded in the structure of the communities in which they occur. First, they require the knowledge of the social and cultural context in which they occur. They can be solved only by understanding of what people do and why they do it. Second, they require a multidisciplinary approach. Wicked problems can have different solutions, so it is critical to capture the full range of possibilities and interpretations. Thus, we suggest that Università Cattolica del Sacro Cuore (UCSC) is well suited for accepting and managing this challenge because of its applied research orientation, multidisciplinary approach, and integrated vision. After presenting the research activity of UCSC, we describe a possible "systems thinking" strategy to consider the complexity and interdependence of active ageing and healthy living.

  17. Effects of a Research-Based Intervention to Improve Seventh-Grade Students' Proportional Problem Solving: A Cluster Randomized Trial

    Science.gov (United States)

    Jitendra, Asha K.; Harwell, Michael R.; Dupuis, Danielle N.; Karl, Stacy R.; Lein, Amy E.; Simonson, Gregory; Slater, Susan C.

    2015-01-01

    This experimental study evaluated the effectiveness of a research-based intervention, schema-based instruction (SBI), on students' proportional problem solving. SBI emphasizes the underlying mathematical structure of problems, uses schematic diagrams to represent information in the problem text, provides explicit problem-solving and metacognitive…

  18. Subsynchronous Oscillation Problem Research in the UHVDC System of a Regional Power Grid in China

    Directory of Open Access Journals (Sweden)

    Qu Ying

    2016-01-01

    Full Text Available Along with the grid structure being more and more complex and the rapid development of the HVDC system, studying the subsynchronous oscillation (SSO problem on HVDC system has more engineering practice significance. The paper studies subsynchronous oscillations problem of generators near the ±800kV UHVDC converter station, and analyzes the subsynchronous oscillation possibilities through PSCAD/EMTDC simulation. At last, though the researched UHVDC thermal plants have none SSO risk but it needs other measures to make the relevant generators return on normal operation.

  19. Promises and challenges of stem cell research for regenerative medicine.

    Science.gov (United States)

    Power, Carl; Rasko, John E J

    2011-11-15

    In recent years, stem cells have generated increasing excitement, with frequent claims that they are revolutionizing medicine. For those not directly involved in stem cell research, however, it can be difficult to separate fact from fiction or realistic expectation from wishful thinking. This article aims to provide internists with a clear and concise introduction to the field. While recounting some scientific and medical milestones, the authors discuss the 3 main varieties of stem cells-adult, embryonic, and induced pluripotent-comparing their advantages and disadvantages for clinical medicine. The authors have sought to avoid the moral and political debates surrounding stem cell research, focusing instead on scientific and medical issues.

  20. Bioethics and the Stem Cell Research Debate

    Science.gov (United States)

    Shapiro, Robyn S.

    2006-01-01

    Bioethics--the study of ethical issues in science and medicine--has grown to become a significant academic and service-oriented discipline with its own research centers, conferences, journals, and degree programs. As these issues have moved to the center of public debate, the law has assumed an increasingly important place in the discipline of…

  1. Research program on climatic and environmental problems. Summary of Norwegian climatic and ozone layer research in the last decade and important research tasks in the future

    International Nuclear Information System (INIS)

    Dahlin, Elin

    1999-04-01

    This report includes 44 abstracts, 21 lectures and 23 posters from a workshop arranged by the Norwegian Research Council, the Steering Group for the Norwegian research programme for changes in climate and ozone layer. The topics dealt with are: Results from the research, the greenhouse effect and its influence on the climate of today, the interactions between ocean and climate, pollution influence on ozone layer changes, the UV radiation effects and their influence on the environment, climatic modelling and forecasting, ecological problems related to climatic and environmental changes, the climatic influences of human energy utilisation and suggestions for future research

  2. Derivation of porcine pluripotent stem cells for biomedical research.

    Science.gov (United States)

    Shiue, Yow-Ling; Yang, Jenn-Rong; Liao, Yu-Jing; Kuo, Ting-Yung; Liao, Chia-Hsin; Kang, Ching-Hsun; Tai, Chein; Anderson, Gary B; Chen, Lih-Ren

    2016-07-01

    Pluripotent stem cells including embryonic stem cells (ESCs), embryonic germ cells (EGCs), and induced pluripotent stem cells (iPSCs) are capable of self-renew and limitlessly proliferating in vitro with undifferentiated characteristics. They are able to differentiate in vitro, spontaneously or responding to suitable signals, into cells of all three primary germ layers. Consequently, these pluripotent stem cells will be valuable sources for cell replacement therapy in numerous disorders. However, the promise of human ESCs and EGCs is cramped by the ethical argument about destroying embryos and fetuses for cell line creation. Moreover, there are still carcinogenic risks existing toward the goal of clinical application for human ESCs, EGCs, and iPSCs. Therefore, a suitable animal model for stem cell research will benefit the further development of human stem cell technology. The pigs, on the basis of their similarity in anatomy, immunology, physiology, and biochemical properties, have been wide used as model animals in the study of various human diseases. The development of porcine pluripotent stem cell lines will hold the opportunity to provide an excellent material for human counterpart to the transplantation in biomedical research and further development of cell-based therapeutic strategy. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Children's Media Use and Sleep Problems: Issues and Unanswered Questions. Research Brief

    Science.gov (United States)

    Zimmerman, Frederick J.

    2008-01-01

    Research shows that most children and adolescents do not get enough high-quality sleep, and that their sleep times appear to have declined over the last two decades. Coinciding with this trend has been the rise in popularity of new media forms including the Internet, video games, cell phones and DVDs. Because of the immediacy and interactivity of…

  4. The New Federalism: State Policies Regarding Embryonic Stem Cell Research.

    Science.gov (United States)

    Acosta, Nefi D; Golub, Sidney H

    2016-09-01

    Stem cell policy in the United States is an amalgam of federal and state policies. The scientific development of human pluripotent embryonic stem cells (ESCs) triggered a contentious national stem cell policy debate during the administration of President George W. Bush. The Bush "compromise" that allowed federal funding to study only a very limited number of ESC derived cell lines did not satisfy either the researchers or the patient advocates who saw great medical potential being stifled. Neither more restrictive legislation nor expansion of federal funding proved politically possible and the federal impasse opened the door for a variety of state-based experiments. In 2004, California became the largest and most influential state venture into stem cell research by passing "Prop 71," a voter initiative that created a new stem cell agency and funded it with $3 billion. Several states followed suit with similar programs to protect the right of investigators to do stem cell research and in some cases to invest state funding in such projects. Other states devised legislation to restrict stem cell research and in five states, criminal penalties were included. Thus, the US stem cell policy is a patchwork of multiple, often conflicting, state and federal policies. © 2016 American Society of Law, Medicine & Ethics.

  5. Excursions in classical analysis pathways to advanced problem solving and undergraduate research

    CERN Document Server

    Chen, Hongwei

    2010-01-01

    Excursions in Classical Analysis introduces undergraduate students to advanced problem solving and undergraduate research in two ways. Firstly, it provides a colourful tour of classical analysis which places a wide variety of problems in their historical context. Secondly, it helps students gain an understanding of mathematical discovery and proof. In demonstrating a variety of possible solutions to the same sample exercise, the reader will come to see how the connections between apparently inapplicable areas of mathematics can be exploited in problem-solving. This book will serve as excellent preparation for participation in mathematics competitions, as a valuable resource for undergraduate mathematics reading courses and seminars and as a supplement text in a course on analysis. It can also be used in independent study, since the chapters are free-standing.

  6. Progress in InP solar cell research

    International Nuclear Information System (INIS)

    Weinberg, I.; Brinker, D.J.

    1988-01-01

    Progress, in the past year, in InP solar cell research is reviewed. Small area cells with AMO, total area efficiencies of 18.8 percent were produced by OMCVD and Ion Implantation. Larger area cells (2 and 4 sq cm) were processed on a production basis. One thousand of the 2 sq cm cells will be used to supply power to a small piggyback lunar orbiter scheduled for launch in February 1990. Laboratory tests of ITO/InP cells, under 10 MeV proton irradiation, indicate radiation resistance comparable to InP n/p homojunction cells. Computer modeling studies indicate that, for identical geometries and dopant concentrations, InP solar cells are significantly more radiation resistant than GaAs under 1 MeV electron irradiation. Additional computer modeling calculations were used to produce rectangular and circular InP concentrator cell designs for both the low concentration SLATS and higher concentration Cassegrainian Concentrators

  7. ETHICAL REVIEW OF BIOMEDICAL RESEARCH IN BELARUS: CURRENT STATUS, PROBLEMS AND PERSPECTIVES.

    Science.gov (United States)

    Famenka, Andrei

    2011-04-01

    The paper provides description of the system of ethical review for biomedical research in Belarus, with special emphasis on its historical background, legal and regulatory framework, structure and functioning. It concludes that the situation with research ethics in Belarus corresponds to the tendency of bureaucratic approach to establishment of systems of ethical review for biomedical research, observed in a number of countries of Central and Eastern Europe. Different social, economical and political factors of transition have major impact on capacities of the Belarusian RECs to ensure adequate protection of human subjects. Among the main problems identified are non-equivalent stringency of ethical review for different types of biomedical research; lack of independence, multidisciplinarity, pluralism and lay representation experienced by RECs; low level of research ethics education and transparency of RECs activities. Recommendations are made to raise the issue of research ethics on the national agenda in order to develop and maintain the research ethics system capable to effectively protect research participants and promote ethical conduct in research.

  8. Pluripotent stem cell-derived neural stem cells: From basic research to applications

    OpenAIRE

    Otsu, Masahiro; Nakayama, Takashi; Inoue, Nobuo

    2014-01-01

    Basic research on pluripotent stem cells is designed to enhance understanding of embryogenesis, whereas applied research is designed to develop novel therapies and prevent diseases. Attainment of these goals has been enhanced by the establishment of embryonic stem cell lines, the technological development of genomic reprogramming to generate induced-pluripotent stem cells, and improvements in vitro techniques to manipulate stem cells. This review summarizes the techniques required to generate...

  9. Stem cell research ethics: consensus statement on emerging issues.

    Science.gov (United States)

    Caulfield, Timothy; Ogbogu, Ubaka; Nelson, Erin; Einsiedel, Edna; Knoppers, Bartha; McDonald, Michael; Brunger, Fern; Downey, Robin; Fernando, Kanchana; Galipeau, Jacques; Geransar, Rose; Griener, Glenn; Grenier, Glenn; Hyun, Insoo; Isasi, Rosario; Kardel, Melanie; Knowles, Lori; Kucic, Terrence; Lotjonen, Salla; Lyall, Drew; Magnus, David; Mathews, Debra J H; Nisbet, Matthew; Nisker, Jeffrey; Pare, Guillaume; Pattinson, Shaun; Pullman, Daryl; Rudnicki, Michael; Williams-Jones, Bryn; Zimmerman, Susan

    2007-10-01

    This article is a consensus statement by an international interdisciplinary group of academic experts and Canadian policy-makers on emerging ethical, legal and social issues in human embryonic stem cells (hESC) research in Canada. The process of researching consensus included consultations with key stakeholders in hESC research (regulations, stem cell researchers, and research ethics experts), preparation and distribution of background papers, and an international workshop held in Montreal in February 2007 to discuss the papers and debate recommendations. The recommendations provided in the consensus statement focus on issues of immediate relevance to Canadian policy-makers, including informed consent to hESC research, the use of fresh embryos in research, management of conflicts of interest, and the relevance of public opinion research to policy-making.

  10. Teaching medical students to discern ethical problems in human clinical research studies.

    Science.gov (United States)

    Roberts, Laura Weiss; Warner, Teddy D; Green Hammond, Katherine A; Brody, Janet L; Kaminsky, Alexis; Roberts, Brian B

    2005-10-01

    Investigators and institutional review boards are entrusted with ensuring the conduct of ethically sound human studies. Assessing ethical aspects of research protocols is a key skill in fulfilling this duty, yet no empirically validated method exists for preparing professionals to attain this skill. The authors performed a randomized controlled educational intervention, comparing a criteria-based learning method, a clinical-research- and experience-based learning method, and a control group. All 300 medical students enrolled at the University of New Mexico School of Medicine in 2001 were invited to participate. After a single half-hour educational session, a written posttest of ability to detect ethical problems in hypothetical protocol vignettes was administered. The authors analyzed responses to ten protocol vignettes that had been evaluated independently by experts. For each vignette, a global assessment of the perceived significance of ethical problems and the identification of specific ethical problems were evaluated. Eighty-three medical students (27%) volunteered: 50 (60%) were women and 55 (66%) were first- and second-year students. On global assessments, the criteria-focused group perceived ethical problems as more significant than did the other two groups (p evaluation skills. This work supports the potential value of empirically derived methods for preparing professionals to discern ethical aspects of human studies.

  11. Convergence of Cell Based Finite Volume Discretizations for Problems of Control in the Conduction Coefficients

    DEFF Research Database (Denmark)

    Evgrafov, Anton; Gregersen, Misha Marie; Sørensen, Mads Peter

    2011-01-01

    We present a convergence analysis of a cell-based finite volume (FV) discretization scheme applied to a problem of control in the coefficients of a generalized Laplace equation modelling, for example, a steady state heat conduction. Such problems arise in applications dealing with geometric optimal......, whereas the convergence of the coefficients happens only with respect to the "volumetric" Lebesgue measure. Additionally, depending on whether the stationarity conditions are stated for the discretized or the original continuous problem, two distinct concepts of stationarity at a discrete level arise. We...... provide characterizations of limit points, with respect to FV mesh size, of globally optimal solutions and two types of stationary points to the discretized problems. We illustrate the practical behaviour of our cell-based FV discretization algorithm on a numerical example....

  12. Single cell biology beyond the era of antibodies: relevance, challenges, and promises in biomedical research.

    Science.gov (United States)

    Abraham, Parvin; Maliekal, Tessy Thomas

    2017-04-01

    Research of the past two decades has proved the relevance of single cell biology in basic research and translational medicine. Successful detection and isolation of specific subsets is the key to understand their functional heterogeneity. Antibodies are conventionally used for this purpose, but their relevance in certain contexts is limited. In this review, we discuss some of these contexts, posing bottle neck for different fields of biology including biomedical research. With the advancement of chemistry, several methods have been introduced to overcome these problems. Even though microfluidics and microraft array are newer techniques exploited for single cell biology, fluorescence-activated cell sorting (FACS) remains the gold standard technique for isolation of cells for many biomedical applications, like stem cell therapy. Here, we present a comprehensive and comparative account of some of the probes that are useful in FACS. Further, we illustrate how these techniques could be applied in biomedical research. It is postulated that intracellular molecular markers like nucleostemin (GNL3), alkaline phosphatase (ALPL) and HIRA can be used for improving the outcome of cardiac as well as bone regeneration. Another field that could utilize intracellular markers is diagnostics, and we propose the use of specific peptide nucleic acid probes (PNPs) against certain miRNAs for cancer surgical margin prediction. The newer techniques for single cell biology, based on intracellular molecules, will immensely enhance the repertoire of possible markers for the isolation of cell types useful in biomedical research.

  13. Introduction of hot cell facility in research center Rez - Poster

    International Nuclear Information System (INIS)

    Petrickova, A.; Srba, O.; Miklos, M.; Svoboda, P.

    2015-01-01

    This poster presents the hot cell facility which is being constructed as part of the SUSEN project at the Rez research center (Czech Republic). Within this project a new complex of 10 hot cells and one semi-hot cell will be built. There will be 8 gamma hot cells and 2 alpha hot cells. In each hot cell a hermetic, removable box made of stainless steel will home different type of devices. The hot cells and semi hot cell will be equipped with devices for processing samples (cutting, welding, drilling, machining) as well as equipment for testing (sample preparation area, stress testing machine, fatigue machine, electromechanical creep machine, high frequency resonance pulsator...) and equipment for studying material microstructure (nano-indenter with nano-scratch tester and scanning electron microscope). An autoclave with water loop, installed in a cell will allow mechanical testing in control environment of water, pressure and temperature. A scheme shows the equipment of each cell. This hot laboratory will be able to cover all the process to study radioactive materials: receiving the material, the preparation of the samples, mechanical testing and microstructure observation. Our hot cells will be close to the research nuclear reactor LVR-15 and new irradiation facility (high irradiation by cobalt source) is planned to be built within the SUSEN project

  14. Research on human placenta-derived mesenchymal stem cells ...

    African Journals Online (AJOL)

    Research on human placenta-derived mesenchymal stem cells transfected with pIRES2-EGFP-VEGF165 using liposome. ... African Journal of Biotechnology. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue ...

  15. The ethical dilemma of embryonic stem cell research.

    Science.gov (United States)

    Manzar, Nabeel; Manzar, Bushra; Hussain, Nuzhat; Hussain, M Fawwad Ahmed; Raza, Sajjad

    2013-03-01

    To determine the knowledge, attitude, and ethical concerns of medical students and graduates with regard to Embryonic Stem Cell (ESC) research. This questionnaire based descriptive study was conducted at the Civil Hospital Karachi (CHK), Pakistan from February to July 2008. A well structured questionnaire was administered to medical students and graduate doctors, which included their demographic profile as well as questions in line with the study objective. Informed consent was taken and full confidentiality was assured to the participants. Data were entered in a Statistical Package for Social Sciences (SPSS version.12) and analyzed. A total of 204 male and 216 female medical students and doctors were administered questionnaires out of which 105 males (51.4%) and 108 females (50%) were aware of the embryonic stem cell research and its ethical implications. Forty percent males and 47% of females were of the opinion that life begins at conception. Forty-six percent males and 39% females were in favor of stem cell research while only 31% males and 28% females supported the ESC research. Less than 1/3 of students supported using frozen embryos for research purposes while more than 2/3 indicated that they were unlikely to support abortion for stem cell research purposes. The majority of the students were in favor of stem cell research with some reservations regarding ESC research. A sizeable number of students withheld their views, reflecting their poor understanding of medical ethics. The result of the study indicates a need for incorporating bioethics into the medical curriculum.

  16. Pioneering space research in the USSR and mathematical modeling of large problems of radiation transfer

    International Nuclear Information System (INIS)

    Sushkevich, T.A.

    2011-01-01

    This review is to remind scientists of the older generation of some memorable historical pages and of many famous researchers, teachers and colleagues. For the younger researchers and foreign colleagues it will be useful to get to know about pioneer advancements of the Soviet scientists in the field of information and mathematical supply for cosmonautic problems on the eve of the space era. Main attention is paid to the scientific experiments conducted on the piloted space vehicles and the research teams who created the information and mathematical tools for the first space projects. The role of Mstislav Vsevolodovich Keldysh, the Major Theoretician of cosmonautics, is particularly emphasized. He determined for the most part the basic directions of development of space research and remote sensing of the Earth and planets that are shortly called remote sensing

  17. Problems with change in R2 as applied to theory of reasoned action research.

    Science.gov (United States)

    Trafimow, David

    2004-12-01

    The paradigm of choice for theory of reasoned action research seems to depend largely on the notion of change in variance accounted for (DeltaR2) as new independent variables are added to a multiple regression equation. If adding a particular independent variable of interest increases the variance in the dependent variable that can be accounted for by the list of independent variables, then the research is deemed to be 'successful', and the researcher is considered to have made a convincing argument about the importance of the new variable. In contrast to this trend, I present arguments that suggest serious problems with the paradigm, and conclude that studies on attitude-behaviour relations would advance the field of psychology to a far greater extent if researchers abandoned it.

  18. Biorefinery and Hydrogen Fuel Cell Research

    Energy Technology Data Exchange (ETDEWEB)

    K.C. Das; Thomas T. Adams; Mark A. Eiteman; John Stickney; Joy Doran Peterson; James R. Kastner; Sudhagar Mani; Ryan Adolphson

    2012-06-12

    In this project we focused on several aspects of technology development that advances the formation of an integrated biorefinery. These focus areas include: [1] establishment of pyrolysis processing systems and characterization of the product oils for fuel applications, including engine testing of a preferred product and its pro forma economic analysis; [2] extraction of sugars through a novel hotwater extaction process, and the development of levoglucosan (a pyrolysis BioOil intermediate); [3] identification and testing of the use of biochar, the coproduct from pyrolysis, for soil applications; [4] developments in methods of atomic layer epitaxy (for efficient development of coatings as in fuel cells); [5] advancement in fermentation of lignocellulosics, [6] development of algal biomass as a potential substrate for the biorefinery, and [7] development of catalysts from coproducts. These advancements are intended to provide a diverse set of product choices within the biorefinery, thus improving the cost effectiveness of the system. Technical effectiveness was demonstrated in the pyrolysis biooil based diesel fuel supplement, sugar extraction from lignocelluose, use of biochar, production of algal biomass in wastewaters, and the development of catalysts. Economic feasibility of algal biomass production systems seems attractive, relative to the other options. However, further optimization in all paths, and testing/demonstration at larger scales are required to fully understand the economic viabilities. The various coproducts provide a clear picture that multiple streams of value can be generated within an integrated biorefinery, and these include fuels and products.

  19. PN solutions for the slowing-down and the cell calculation problems in plane geometry

    International Nuclear Information System (INIS)

    Caldeira, Alexandre David

    1999-01-01

    In this work P N solutions for the slowing-down and cell problems in slab geometry are developed. To highlight the main contributions of this development, one can mention: the new particular solution developed for the P N method applied to the slowing-down problem in the multigroup model, originating a new class of polynomials denominated Chandrasekhar generalized polynomials; the treatment of a specific situation, known as a degeneracy, arising from a particularity in the group constants and the first application of the P N method, for arbitrary N, in criticality calculations at the cell level reported in literature. (author)

  20. Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: Utility and pitfalls

    Directory of Open Access Journals (Sweden)

    Ashley R.P. Hinson

    2013-07-01

    Full Text Available Rhabdomyosarcoma (RMS is the most common soft tissue sarcoma of childhood and adolescence. Despite intergroup clinical trials conducted in Europe and North America, outcomes for high risk patients with this disease have not significantly improved in the last several decades, and survival of metastatic or relapsed disease remains extremely poor. Accrual into new clinical trials is slow and difficult, so in vitro cell line research and in vivo xenograft models present an attractive alternative for preclinical research for this cancer type. Currently, 30 commonly used human RMS cell lines exist, with differing origins, karyotypes, histologies, and methods of validation. Selecting an appropriate cell line for RMS research has important implications for outcomes. There are also potential pitfalls in using certain cell lines including contamination with murine stromal cells, cross-contamination between cell lines, discordance between the cell line and its associated original tumor, imposter cell lines, and nomenclature errors that result in the circulation of two or more presumed unique cell lines that are actually from the same origin. These pitfalls can be avoided by testing for species-specific isoenzymes, microarray analysis, assays for subtype-specific fusion products, and short tandem repeat analysis.

  1. Human Rhabdomyosarcoma Cell Lines for Rhabdomyosarcoma Research: Utility and Pitfalls

    Science.gov (United States)

    Hinson, Ashley R. P.; Jones, Rosanne; Crose, Lisa E. S.; Belyea, Brian C.; Barr, Frederic G.; Linardic, Corinne M.

    2013-01-01

    Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence. Despite intergroup clinical trials conducted in Europe and North America, outcomes for high risk patients with this disease have not significantly improved in the last several decades, and survival of metastatic or relapsed disease remains extremely poor. Accrual into new clinical trials is slow and difficult, so in vitro cell-line research and in vivo xenograft models present an attractive alternative for preclinical research for this cancer type. Currently, 30 commonly used human RMS cell lines exist, with differing origins, karyotypes, histologies, and methods of validation. Selecting an appropriate cell line for RMS research has important implications for outcomes. There are also potential pitfalls in using certain cell lines including contamination with murine stromal cells, cross-contamination between cell lines, discordance between the cell line and its associated original tumor, imposter cell lines, and nomenclature errors that result in the circulation of two or more presumed unique cell lines that are actually from the same origin. These pitfalls can be avoided by testing for species-specific isoenzymes, microarray analysis, assays for subtype-specific fusion products, and short tandem repeat analysis. PMID:23882450

  2. Stem cells: basic research on health, from ethics to panacea

    Directory of Open Access Journals (Sweden)

    Naara Luna

    2007-01-01

    Full Text Available Even though stem cell therapies are still under experimentation, the media has represented them as a panacea that would cure all diseases. This fact secured the authorization for using human embryos as research material. Therapies include manipulation of human material in tissue bioengineering, suggesting a representation of the body as a factory. This article describes stem cell research projects being carried out in the health sciences center of a higher education institution, focusing on field organization and on the system of values underlying scientific activity. Researchers at different levels were interviewed about perspectives on, and implications of, their research in order to analyze the discourse of the projects' participants. Experiments with adult stem cells enjoyed wide support, while the use of human embryos was disputed. The foundations of those arguments were sought in their relation both to the structure of the scientific field and to the researchers' religious background.

  3. Clinical perspectives of cancer stem cell research in radiation oncology

    International Nuclear Information System (INIS)

    Bütof, Rebecca; Baumann, Michael; Dubrovska, Anna

    2013-01-01

    Radiotherapy has a proven potential to eradicate cancer stem cells which is reflected by its curative potential in many cancer types. Considerable progress has been made in identification and biological characterisation of cancer stem cells during the past years. Recent biological findings indicate significant inter- and intratumoural and functional heterogeneity of cancer stem cells and lead to more complex models which have potential implications for radiobiology and radiotherapy. Clinical evidence is emerging that biomarkers of cancer stem cells may be prognostic for the outcome of radiotherapy in some tumour entities. Perspectives of cancer stem cell based research for radiotherapy reviewed here include their radioresistance compared to the mass of non-cancer stem cells which form the bulk of all tumour cells, implications for image- and non-image based predictive bio-assays of the outcome of radiotherapy and a combination of novel systemic treatments with radiotherapy

  4. Application of single-cell technology in cancer research.

    Science.gov (United States)

    Liang, Shao-Bo; Fu, Li-Wu

    2017-07-01

    In this review, we have outlined the application of single-cell technology in cancer research. Single-cell technology has made encouraging progress in recent years and now provides the means to detect rare cancer cells such as circulating tumor cells and cancer stem cells. We reveal how this technology has advanced the analysis of intratumor heterogeneity and tumor epigenetics, and guided individualized treatment strategies. The future prospects now are to bring single-cell technology into the clinical arena. We believe that the clinical application of single-cell technology will be beneficial in cancer diagnostics and treatment, and ultimately improve survival in cancer patients. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  5. Some applications of nanotechnologies in stem cells research

    International Nuclear Information System (INIS)

    Belicchi, M.; Cancedda, R.; Cedola, A.; Fiori, F.; Gavina, M.; Giuliani, A.; Komlev, V.S.; Lagomarsino, S.; Mastrogiacomo, M.; Renghini, C.; Rustichelli, F.

    2009-01-01

    Stem cell based tissue engineering therapies involve the administration of ex vivo manipulated stem cell populations with the purpose of repairing and regenerating damaged or diseased tissue. Currently available methods of monitoring transplanted cells are quite limited. To monitor the outcomes of stem cell therapy longitudinally requires the development of non-destructive strategies that are capable of identifying the location, magnitude, and duration of cellular survival and fate. The recent development of imaging techniques offers great potential to address these critical issues by non-invasively tracking the fate of the transplanted cells. This review offers a focused presentation of some examples of the use of imaging techniques connected to the nanotechnological world in research areas related to stem cells. In particular investigations will be considered concerning tissue-engineered bone, treatment of intervertebral disc degeneration, treatment by human stem cells of muscular dystrophy of Duchenne in small animal models and the repair of spinal cord injuries.

  6. Nanotechnology in stem cells research: advances and applications.

    Science.gov (United States)

    Deb, Kaushik Dilip; Griffith, May; Muinck, Ebo De; Rafat, Mehrdad

    2012-01-01

    Human beings suffer from a myriad of disorders caused by biochemical or biophysical alteration of physiological systems leading to organ failure. For a number of these conditions, stem cells and their enormous reparative potential may be the last hope for restoring function to these failing organ or tissue systems. To harness the potential of stem cells for biotherapeutic applications, we need to work at the size scale of molecules and processes that govern stem cells fate. Nanotechnology provides us with such capacity. Therefore, effective amalgamation of nanotechnology and stem cells - medical nanoscience or nanomedicine - offers immense benefits to the human race. The aim of this paper is to discuss the role and importance of nanotechnology in stem cell research by focusing on several important areas such as stem cell visualization and imaging, genetic modifications and reprogramming by gene delivery systems, creating stem cell niche, and similar therapeutic applications.

  7. Some applications of nanotechnologies in stem cells research

    Energy Technology Data Exchange (ETDEWEB)

    Belicchi, M. [Fondazione IRCCS Ospedale Policlinico di Milano, Via Francesco Sforza, Milano 20122 (Italy); Cancedda, R. [Istituto Nazionale per la Ricerca sul Cancro and Dipartimento di Oncologia Biologia e Genetica - Universita di Genova, Largo R. Benzi 10, Genova 16132 (Italy); Cedola, A. [Istituto di Fotonica e Nanotecnologie - CNR, Via Cinto Romano 42, Roma 00156 (Italy); Fiori, F. [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); INBB - Istituto Nazionale Biostrutture e Biosistemi (Italy); CNISM - Matec (Ancona) (Italy); Gavina, M. [Fondazione IRCCS Ospedale Policlinico di Milano, Via Francesco Sforza, Milano 20122 (Italy); Giuliani, A. [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); CNISM - Matec (Ancona) (Italy); Komlev, V.S. [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); Institute for Physical Chemistry of Ceramics, Russian Academy of Sciences, Ozernaya 48, 119361 Moscow (Russian Federation); Lagomarsino, S. [Istituto di Fotonica e Nanotecnologie - CNR, Via Cinto Romano 42, Roma 00156 (Italy); Mastrogiacomo, M. [Istituto Nazionale per la Ricerca sul Cancro and Dipartimento di Oncologia Biologia e Genetica - Universita di Genova, Largo R. Benzi 10, Genova 16132 (Italy); Renghini, C. [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); INBB - Istituto Nazionale Biostrutture e Biosistemi (Italy); CNISM - Matec (Ancona) (Italy); Rustichelli, F., E-mail: f.rustichelli@univpm.i [Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Bianche, Ancona 60131 (Italy); INBB - Istituto Nazionale Biostrutture e Biosistemi (Italy); CNISM - Matec (Ancona) (Italy)

    2009-12-15

    Stem cell based tissue engineering therapies involve the administration of ex vivo manipulated stem cell populations with the purpose of repairing and regenerating damaged or diseased tissue. Currently available methods of monitoring transplanted cells are quite limited. To monitor the outcomes of stem cell therapy longitudinally requires the development of non-destructive strategies that are capable of identifying the location, magnitude, and duration of cellular survival and fate. The recent development of imaging techniques offers great potential to address these critical issues by non-invasively tracking the fate of the transplanted cells. This review offers a focused presentation of some examples of the use of imaging techniques connected to the nanotechnological world in research areas related to stem cells. In particular investigations will be considered concerning tissue-engineered bone, treatment of intervertebral disc degeneration, treatment by human stem cells of muscular dystrophy of Duchenne in small animal models and the repair of spinal cord injuries.

  8. Development of New Technologies for Stem Cell Research

    Directory of Open Access Journals (Sweden)

    Xibo Ma

    2012-01-01

    Full Text Available Since the 1960s, the stem cells have been extensively studied including embryonic stem cells, neural stem cells, bone marrow hematopoietic stem cells, and mesenchymal stem cells. In the recent years, several stem cells have been initially used in the treatment of diseases, such as in bone marrow transplant. At the same time, isolation and culture experimental technologies for stem cell research have been widely developed in recent years. In addition, molecular imaging technologies including optical molecular imaging, positron emission tomography, single-photon emission computed tomography, and computed tomography have been developed rapidly in recent the 10 years and have also been used in the research on disease mechanism and evaluation of treatment of disease related with stem cells. This paper will focus on recent typical isolation, culture, and observation techniques of stem cells followed by a concise introduction. Finally, the current challenges and the future applications of the new technologies in stem cells are given according to the understanding of the authors, and the paper is then concluded.

  9. Application of ac impedance in fuel cell research and development

    Energy Technology Data Exchange (ETDEWEB)

    Selman, J R; Lin, Y P [Illinois Inst. of Tech., Chicago, IL (United States). Dept. of Chemical Engineering

    1993-10-01

    In applying ac impedance to fuel cells and their porous (gas diffusion) electrodes the emphasis lies on different fuel cell components, and their properties, according to the fuel cell type. The focus has been directed at the electrode/electrolyte interface in MCFC and PAFC, whereas in SOFC and PEMFC the ionic/electronic conductivity of the electrolyte or the characteristics of its composite with the electrocatalyst is of primary interest. The limitations of ac impedance in fuel cell application are in part due to difficulties of interpretation and in part due to experimental difficulties because of the generally fast electrode reaction kinetics. Further research directions are indicated. (author)

  10. Application of Operational Research Techniques in Operating Room Scheduling Problems: Literature Overview

    Directory of Open Access Journals (Sweden)

    Şeyda Gür

    2018-01-01

    Full Text Available Increased healthcare costs are pushing hospitals to reduce costs and increase the quality of care. Operating rooms are the most important source of income and expense for hospitals. Therefore, the hospital management focuses on the effectiveness of schedules and plans. This study includes analyses of recent research on operating room scheduling and planning. Most studies in the literature, from 2000 to the present day, were evaluated according to patient characteristics, performance measures, solution techniques used in the research, the uncertainty of the problem, applicability of the research, and the planning strategy to be dealt within the solution. One hundred seventy studies were examined in detail, after scanning the Emerald, Science Direct, JSTOR, Springer, Taylor and Francis, and Google Scholar databases. To facilitate the identification of these studies, they are grouped according to the different criteria of concern and then, a detailed overview is presented.

  11. Quality of life of people with mental health problems: a synthesis of qualitative research.

    Science.gov (United States)

    Connell, Janice; Brazier, John; O'Cathain, Alicia; Lloyd-Jones, Myfanwy; Paisley, Suzy

    2012-11-22

    To identify the domains of quality of life important to people with mental health problems. A systematic review of qualitative research undertaken with people with mental health problems using a framework synthesis. We identified six domains: well-being and ill-being; control, autonomy and choice; self-perception; belonging; activity; and hope and hopelessness. Firstly, symptoms or 'ill-being' were an intrinsic aspect of quality of life for people with severe mental health problems. Additionally, a good quality of life was characterised by the feeling of being in control (particularly of distressing symptoms), autonomy and choice; a positive self-image; a sense of belonging; engagement in meaningful and enjoyable activities; and feelings of hope and optimism. Conversely, a poor quality life, often experienced by those with severe mental health difficulties, was characterized by feelings of distress; lack of control, choice and autonomy; low self-esteem and confidence; a sense of not being part of society; diminished activity; and a sense of hopelessness and demoralization. Generic measures fail to address the complexity of quality of life measurement and the broad range of domains important to people with mental health problems.

  12. Quality of life of people with mental health problems: a synthesis of qualitative research

    Directory of Open Access Journals (Sweden)

    Connell Janice

    2012-11-01

    Full Text Available Abstract Purpose To identify the domains of quality of life important to people with mental health problems. Method A systematic review of qualitative research undertaken with people with mental health problems using a framework synthesis. Results We identified six domains: well-being and ill-being; control, autonomy and choice; self-perception; belonging; activity; and hope and hopelessness. Firstly, symptoms or ‘ill-being’ were an intrinsic aspect of quality of life for people with severe mental health problems. Additionally, a good quality of life was characterised by the feeling of being in control (particularly of distressing symptoms, autonomy and choice; a positive self-image; a sense of belonging; engagement in meaningful and enjoyable activities; and feelings of hope and optimism. Conversely, a poor quality life, often experienced by those with severe mental health difficulties, was characterized by feelings of distress; lack of control, choice and autonomy; low self-esteem and confidence; a sense of not being part of society; diminished activity; and a sense of hopelessness and demoralization. Conclusions Generic measures fail to address the complexity of quality of life measurement and the broad range of domains important to people with mental health problems.

  13. Some problems with non-inferiority tests in psychotherapy research: psychodynamic therapies as an example.

    Science.gov (United States)

    Rief, Winfried; Hofmann, Stefan G

    2018-02-14

    In virtually every field of medicine, non-inferiority trials and meta-analyses with non-inferiority conclusions are increasingly common. This non-inferiority approach has been frequently used by a group of authors favoring psychodynamic therapies (PDTs), concluding that PDTs are just as effective as cognitive-behavioral therapies (CBT). We focus on these examples to exemplify some problems associated with non-inferiority tests of psychological treatments, although the problems also apply to psychopharmacotherapy research, CBT research, and others. We conclude that non-inferiority trials have specific risks of different types of validity problems, usually favoring an (erroneous) non-inferiority conclusion. Non-inferiority trials require the definition of non-inferiority margins, and currently used thresholds have a tendency to be inflationary, not protecting sufficiently against degradation. The use of non-inferiority approaches can lead to the astonishing result that one single analysis can suggest both, superiority of the comparator (here: CBT) and non-inferiority of the other treatment (here PDT) at the same time. We provide recommendations how to improve the quality of non-inferiority trials, and we recommend to consider them among other criteria when evaluating manuscripts examining non-inferiority trials. If psychotherapeutic families (such as PDT and CBT) differ on the number of investigating trials, and in the fields of clinical applications, and in other validity aspects mentioned above, conclusions about their general non-inferiority are no more than a best guess, typically expressing the favored approach of the lead author.

  14. Internet as a resource for solving the problems of adolescence: a review of psychological research

    Directory of Open Access Journals (Sweden)

    A.V. Zhilinskaya,

    2014-08-01

    Full Text Available We analyzed psychological research that consider the Internet as a resource for solving the problems of adolescence. Based on the understanding of self-consciousness as a central adolescence new formation, we formulated a set of tasks of adolescence. It is shown that for the successful solution of age problems by teenagers on the Internet, specialized environments should be designed. Internet as a medium of teenagers’ socialization is characterized by a high degree of variety and uncontrollability. Behavior of adolescents on the Internet depends on the social and cultural context in which they live. The emergence of the Internet makes new demands on media competence of the teenager and his environment. Adolescents face online with a variety of risks. An essential resource for successful adolescent development is the presence of a person whom he trusts, with whom he can consult in difficult situations. The research plan involves the creation of Internet resources, contributing to the solution of teenagers’ problems age, as well as the mapping of the Internet in terms of its developmental potential.

  15. Assessment of Research Needs for Advanced Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Penner, S.S.

    1985-11-01

    The DOE Advanced Fuel Cell Working Group (AFCWG) was formed and asked to perform a scientific evaluation of the current status of fuel cells, with emphasis on identification of long-range research that may have a significant impact on the practical utilization of fuel cells in a variety of applications. The AFCWG held six meetings at locations throughout the country where fuel cell research and development are in progress, for presentations by experts on the status of fuel cell research and development efforts, as well as for inputs on research needs. Subsequent discussions by the AFCWG have resulted in the identification of priority research areas that should be explored over the long term in order to advance the design and performance of fuel cells of all types. Surveys describing the salient features of individual fuel cell types are presented in Chapters 2 to 6 and include elaborations of long-term research needs relating to the expeditious introduction of improved fuel cells. The Introduction and the Summary (Chapter 1) were prepared by AFCWG. They were repeatedly revised in response to comments and criticism. The present version represents the closest approach to a consensus that we were able to reach, which should not be interpreted to mean that each member of AFCWG endorses every statement and every unexpressed deletion. The Introduction and Summary always represent a majority view and, occasionally, a unanimous judgment. Chapters 2 to 6 provide background information and carry the names of identified authors. The identified authors of Chapters 2 to 6, rather than AFCWG as a whole, bear full responsibility for the scientific and technical contents of these chapters.

  16. A Glimpse of Scientific Research on Fundamental Problems of Military and Civil Aeronautics

    Science.gov (United States)

    1939-01-01

    Among the outstanding accomplishments of the last century is man's conquest of the air. That conquest began in 1903 when the Wright brothers made the first successful flight of an airplane at Kitty Hawk, N. C. Five years later the United States Government purchased its first airplane for the use of the Army, and began the training of officers for military flying. During the years immediately preceding the outbreak of the World War the Government and a meager aircraft industry had made important progress, but the Government, practically the only customer, had purchased less than 100 airplanes. In the meantime, leading European nations, sensing acutely the potentialities of aircraft in warfare, had made greater progress and had begun laying the foundations for the new science of aeronautics. The World War gave a remarkable impetus to the development of aeronautics and emphasized the need for organized research on the fundamental problems of flight. By act of Congress approved March 3, 1915, the National Advisory Committee for Aeronautics was created and charged with the duty of supervising, directing, and conducting fundamental scientific research and experiment in aeronautics. With the farsighted support of the Congress the Committee has led the world in the development of unique aeronautical research facilities in its laboratories at Langley Field, Va. The research programs include problems initiated by the Committee and its subcommittees and also investigations requested by the Army, the Navy, and the Civil Aeronautics Authority. The results of researches conducted under one control, serve without duplication of effort, the needs of all branches of aviation, civil and military, and exert a profound influence on the progress of aeronautics by improving the performance, efficiency, and safety of aircraft. A brief description of the results of some of the committee's researches and of the equipment employed will be found in the following pages.

  17. Problem-Solving Test: RNA and Protein Synthesis in Bacteriophage-Infected "E. coli" Cells

    Science.gov (United States)

    Szeberenyi, Jozsef

    2008-01-01

    The classic experiment presented in this problem-solving test was designed to identify the template molecules of translation by analyzing the synthesis of phage proteins in "Escherichia coli" cells infected with bacteriophage T4. The work described in this test led to one of the most seminal discoveries of early molecular biology: it dealt a…

  18. New perspectives in human stem cell therapeutic research

    Directory of Open Access Journals (Sweden)

    Trounson Alan

    2009-06-01

    Full Text Available Abstract Human stem cells are in evaluation in clinical stem cell trials, primarily as autologous bone marrow studies, autologous and allogenic mesenchymal stem cell trials, and some allogenic neural stem cell transplantation projects. Safety and efficacy are being addressed for a number of disease state applications. There is considerable data supporting safety of bone marrow and mesenchymal stem cell transplants but the efficacy data are variable and of mixed benefit. Mechanisms of action of many of these cells are unknown and this raises the concern of unpredictable results in the future. Nevertheless there is considerable optimism that immune suppression and anti-inflammatory properties of mesenchymal stem cells will be of benefit for many conditions such as graft versus host disease, solid organ transplants and pulmonary fibrosis. Where bone marrow and mesenchymal stem cells are being studied for heart disease, stroke and other neurodegenerative disorders, again progress is mixed and mostly without significant benefit. However, correction of multiple sclerosis, at least in the short term is encouraging. Clinical trials on the use of embryonic stem cell derivatives for spinal injury and macular degeneration are beginning and a raft of other clinical trials can be expected soon, for example, the use of neural stem cells for killing inoperable glioma and embryonic stem cells for regenerating β islet cells for diabetes. The change in attitude to embryonic stem cell research with the incoming Obama administration heralds a new co-operative environment for study and evaluation of stem cell therapies. The Californian stem cell initiative (California Institute for Regenerative Medicine has engendered global collaboration for this new medicine that will now also be supported by the US Federal Government. The active participation of governments, academia, biotechnology, pharmaceutical companies, and private investment is a powerful consortium for

  19. Hydrogen and fuel cell research networking in Ontario

    Energy Technology Data Exchange (ETDEWEB)

    Peppley, B.A. [Queen' s-RMC Fuel Cell Research Centre, Kingston, ON (Canada)

    2009-07-01

    This presentation reviewed the activities of the Ontario Fuel Cell Research and Innovation Network since its launch in 2006. Funded by the Ontario Ministry of Research and Innovation, the project involves 17 academic researchers from 8 universities and is supported by 8 industrial partners. The group of researchers has made progress in supporting the developing fuel cell industry in Ontario and in Canada. Their work has the potential to help deploy the province's automotive-oriented manufacturing sector in directions that address the issues of clean air and climate change. New initiatives in the development of hydrogen and fuel cell technologies are instrumental in expanding this network to leverage new business activities in the post financial crisis period. These activities are expected to result in economic benefits for job and economic growth.

  20. How Can We Improve Problem Solving in Undergraduate Biology? Applying Lessons from 30 Years of Physics Education Research

    Science.gov (United States)

    Hoskinson, A.-M.; Caballero, M. D.; Knight, J. K.

    2013-01-01

    If students are to successfully grapple with authentic, complex biological problems as scientists and citizens, they need practice solving such problems during their undergraduate years. Physics education researchers have investigated student problem solving for the past three decades. Although physics and biology problems differ in structure and content, the instructional purposes align closely: explaining patterns and processes in the natural world and making predictions about physical and biological systems. In this paper, we discuss how research-supported approaches developed by physics education researchers can be adopted by biologists to enhance student problem-solving skills. First, we compare the problems that biology students are typically asked to solve with authentic, complex problems. We then describe the development of research-validated physics curricula emphasizing process skills in problem solving. We show that solving authentic, complex biology problems requires many of the same skills that practicing physicists and biologists use in representing problems, seeking relationships, making predictions, and verifying or checking solutions. We assert that acquiring these skills can help biology students become competent problem solvers. Finally, we propose how biology scholars can apply lessons from physics education in their classrooms and inspire new studies in biology education research. PMID:23737623

  1. How can we improve problem solving in undergraduate biology? Applying lessons from 30 years of physics education research.

    Science.gov (United States)

    Hoskinson, A-M; Caballero, M D; Knight, J K

    2013-06-01

    If students are to successfully grapple with authentic, complex biological problems as scientists and citizens, they need practice solving such problems during their undergraduate years. Physics education researchers have investigated student problem solving for the past three decades. Although physics and biology problems differ in structure and content, the instructional purposes align closely: explaining patterns and processes in the natural world and making predictions about physical and biological systems. In this paper, we discuss how research-supported approaches developed by physics education researchers can be adopted by biologists to enhance student problem-solving skills. First, we compare the problems that biology students are typically asked to solve with authentic, complex problems. We then describe the development of research-validated physics curricula emphasizing process skills in problem solving. We show that solving authentic, complex biology problems requires many of the same skills that practicing physicists and biologists use in representing problems, seeking relationships, making predictions, and verifying or checking solutions. We assert that acquiring these skills can help biology students become competent problem solvers. Finally, we propose how biology scholars can apply lessons from physics education in their classrooms and inspire new studies in biology education research.

  2. Taking power, politics, and policy problems seriously: the limits of knowledge translation for urban health research.

    Science.gov (United States)

    Murphy, Kelly; Fafard, Patrick

    2012-08-01

    Knowledge translation (KT) is a growing movement in clinical and health services research, aimed to help make research more relevant and to move research into practice and policy. This paper examines the conventional model of policy change presented in KT and assesses its applicability for increasing the impact of urban health research on urban health policy. In general, KT conceptualizes research utilization in terms of the technical implementation of scientific findings, on the part of individual decision-makers who can be "targeted" for a KT intervention, in a context that is absent of political interests. However, complex urban health problems and interventions infrequently resemble this single decision, single decision-maker model posited by KT. In order to clarify the conditions under which urban health research is more likely or not to have an influence on public policy development, we propose to supplement the conventional model with three concepts drawn from the social science: policy stages, policy networks, and a discourse analysis approach for theorizing power in policy-making.

  3. Means-end chains and laddering: An inventory of problems and an agenda for research

    DEFF Research Database (Denmark)

    Grunert, Klaus G.; Grunert, Suzanne C.; Sørensen, Elin

    Executive summary 1. Means-end chains are a device used to understand how consumers mentally link products to self-relevant consequences. Means-end chains are usually measured by a method called laddering. 2. Means-end chains may fall short of tapping all relevant aspects of how consumers think...... about products. Specifically, nonverbal imagery, episodic information, and procedural knowledge are not included in means-end chains. 3. A number of methodological problems can be identified in the collection of means-end chain data. Major problems, which should be addressed in research, are methods...... to elicit the product attributes the laddering is to start with, the integration of a usage situation in the interview, and the basic decision on how much direct the respondent. 4. Concerning the coding of laddering data, a higher degree of transparency of the coding process would be desirable. 5...

  4. An Existential Perspective on Death Anxiety, Retirement, and Related Research Problems.

    Science.gov (United States)

    Osborne, John W

    2017-06-01

    Aspects of existentialism relevant to existence and death anxiety (DA) are discussed. Included are the "thrownness" of existence, being-with-others, the motivational influence of inevitable death, the search for meaning, making the most of existence by taking responsibility for one's own life, and coping with existential isolation. The attempted separation of DA from object anxiety is a significant difficulty. The correlations among age, gender, and DA are variable. Personality and role-oriented problems in the transition to retirement are discussed along with Erikson's notion of "generativity" as an expression of the energy and purpose of mid-life. Furthermore, methodological and linguistic problems in DA research are considered. The article suggests qualitative methodologies as an interpersonal means of exploring DA within the contexts of psychotherapy and counselling.

  5. Study of a methodology of identifying important research problems by the PIRT process

    International Nuclear Information System (INIS)

    Aoki, Takayuki; Takagi, Toshiyuki; Urayama, Ryoichi; Komura, Ichiro; Furukawa, Takashi; Yusa, Noritaka

    2013-01-01

    In this paper, we propose a new methodology of identifying important research problems to be solved to improve the performance of some specific scientific technologies by the phenomena identification and ranking table (PIRT) process, which has been used as a methodology for demonstrating the validity of the best estimate simulation codes in USNRC licensing of nuclear power plants. It keeps the fundamental concepts of the original PIRT process but makes it possible to identify important factors affecting the performance of the technologies from the viewpoint of the figure of merit and problems associated with them, which need to be solved to improve the performance. Also in this paper, we demonstrate the effectiveness of the developed method by showing a specific example of the application to physical events or phenomena in objects having fatigue or SCC crack(s) under ultrasonic testing and eddy current testing. (author)

  6. The Teaching Model through Problem-Based Learning in a Course on Bibliographic Research

    Directory of Open Access Journals (Sweden)

    Ruth Cristina Hernández-Ching

    2018-02-01

    Full Text Available The experience of applying problem-based learning (PBL technique in the Bibliographic Research course from a Bachelor of English study plan of a public university during the first half of 2014 is shared. The investigation aimed to answer the following question: Does the problem-based learning technique in the Bibliographic Research course allows to implement the main tenets of the teaching model: epistemological foundation, learning theory, methodology and didactics, and communication processes? The research approach proposed was qualitative, and triangulation for measuring variables was implemented. The following instruments were applied: observation, experience record books, and focus groups. Furthermore, formative learning was measured by means of an online survey. Results of the instruments were categorized using technology-based tools such as Wordle (observation, NVivo (record books and MindNode (focus groups. A convenience sampling was used to collect data from eight students enrolled in the Bibliographic Research course, ten students of Integrated English II for non-English majors, and the researcher, as professor of the courses. It was determined that the PBL technique permitted to reach the main tenets of the teaching model. It was identified that the teacher was the main learner, and the one who benefited from the process, since a culture of knowledge, throughout the course, was created. It was also concluded that this technique allowed to develop twenty-first century skills. It would be valuable to quantify whether the development of the four basic skills of English, especially the conversation one, improves using the technique along with technologies.

  7. [Research on problem of exogenous pollution of Chinese medicine resources from perspective of circular economy].

    Science.gov (United States)

    Yang, Yi; Tian, Kan; Tian, Hong

    2016-08-01

    Based on the in-depth analysis of the current situation of the exogenous pollution of Chinese medicine resources, this research mainly discusses the intrinsic link and practical significance between the development of circular economy in Chinese medicine resources and the control of the problem of the exogenous pollution from the perspective of circular economy, and proposes some suggestions to develop the recycling economy of Chinese medicine resources from the establishment of legal system, mechanism of development, production norms, industry standards and regulatory system of the recycling of Chinese medicine resources. Copyright© by the Chinese Pharmaceutical Association.

  8. [Thought on several problems of clinical revaluation of post-marketing herb research].

    Science.gov (United States)

    He, Wei; Xie, Yanming; Wang, Yongyan

    2010-06-01

    The revaluation of post-marketing herb is a complex research work, which concerns widely content and difficult to put it into practice. The starting of our country's revaluation post-marketing herb was comparatively late. It should profect it both in laws and regulations mechanism as well as technological specification. This article is try to focus on some attention problems in revaluation of postmarketing herb process. Such as the laws and regulations demand, the basement and the subject of revaluation of post-marketing herb.

  9. Black boxes on wheels: research challenges and ethical problems in MEA-based robotics

    DEFF Research Database (Denmark)

    Bentzen, Martin Mose

    2016-01-01

    Robotic systems consisting of a neuron culture grown on a multielectrode array (MEA) which is connected to a virtual or mechanical robot have been studied for approximately 15 years. It is hoped that these MEA-based robots will be able to address the problem that robots based on conventional...... and that they are not likely to be solved within the field. After that, I discuss whether MEA-based robotics should be considered pop science. Finally, I investigate the ethical aspects of this research....

  10. Communicating Academic Research Findings to IS Professionals: An Analysis of Problems

    Directory of Open Access Journals (Sweden)

    Michael Lang

    2003-01-01

    Full Text Available Because research findings often do not have direct or immediate relevance to IS professionals in industry, the question arises as to how those findings should be disseminated to them in a suitable form at such time as they do become relevant. A central argument of this paper is that the traditional mechanisms whereby academic researchers disseminate their work are prone to numerous communication breakdowns, and that much work which could potentially make valuable contributions to practice is haplessly lost within the vaults of academia. Using the well-known Shannon & Weaver communication model, three major problems are analyzed: the choice of dissemination channels, language barriers, and the alienation of academia from industry.

  11. French research program on the physiological problems caused by weightlessness. Use of the primate model

    Science.gov (United States)

    Pesquies, P. C.; Milhaud, C.; Nogues, C.; Klein, M.; Cailler, B.; Bost, R.

    The need to acquire a better knowledge of the main biological problems induced by microgravity implies—in addition to human experimentation—the use of animal models, and primates seem to be particularly well adapted to this type of research. The major areas of investigation to be considered are the phospho-calcium metabolism and the metabolism of supporting tissues, the hydroelectrolytic metabolism, the cardiovascular function, awakeness, sleep-awakeness cycles, the physiology of equilibrium and the pathophysiology of space sickness. Considering this program, the Centre d'Etudes et de Recherches de Medecine Aerospatiale, under the sponsorship of the Centre National d'Etudes Spatiales, developed both a program of research on restrained primates for the French-U.S. space cooperation (Spacelab program) and for the French-Soviet space cooperation (Bio-cosmos program), and simulation of the effects of microgravity by head-down bedrest. Its major characteristics are discussed in the study.

  12. PROBLEM OF RESEARCH OF EMOTIONAL DEVELOPMENT OF MENTALLY RETARDED CHILDREN IN FOREIGN PSYCHOLOGY

    Directory of Open Access Journals (Sweden)

    Larisa Valentinovna Shipova

    2016-02-01

    Full Text Available The review of psychology and pedagogical researches of the mentally retarded children devoted to studying of a problem of emotional development in foreign science and practice is presented in article. Various approaches to an assessment of the importance of violations of the emotional sphere of the personality at mentally retarded children for all mental development of the child are considered, need of the accounting of emotional frustration of mentally retarded children for their education and education, and also social adaptation and integration into sociocultural and educational space is discussed. Research of emotional development of mentally retarded children in the course of training is important for development of programs of psychology and pedagogical diagnostics and correction of emotional violations at this category of school students, formation of their self-control, development of the emotional relations.

  13. Overhanging Features and the SLM/DMLS Residual Stresses Problem: Review and Future Research Need

    Directory of Open Access Journals (Sweden)

    Albert E. Patterson

    2017-04-01

    Full Text Available A useful and increasingly common additive manufacturing (AM process is the selective laser melting (SLM or direct metal laser sintering (DMLS process. SLM/DMLS can produce full-density metal parts from difficult materials, but it tends to suffer from severe residual stresses introduced during processing. This limits the usefulness and applicability of the process, particularly in the fabrication of parts with delicate overhanging and protruding features. The purpose of this study was to examine the current insight and progress made toward understanding and eliminating the problem in overhanging and protruding structures. To accomplish this, a survey of the literature was undertaken, focusing on process modeling (general, heat transfer, stress and distortion and material models, direct process control (input and environmental control, hardware-in-the-loop monitoring, parameter optimization and post-processing, experiment development (methods for evaluation, optical and mechanical process monitoring, imaging and design-of-experiments, support structure optimization and overhang feature design; approximately 143 published works were examined. The major findings of this study were that a small minority of the literature on SLM/DMLS deals explicitly with the overhanging stress problem, but some fundamental work has been done on the problem. Implications, needs and potential future research directions are discussed in-depth in light of the present review.

  14. Bioarcheology has a "health" problem: conceptualizing "stress" and "health" in bioarcheological research.

    Science.gov (United States)

    Temple, Daniel H; Goodman, Alan H

    2014-10-01

    This article provides a critical historical overview of the stress concept in bioarcheological research and critically evaluates the term "health" in reference to skeletal samples. Stress has a considerable history in 20th century physiological research, and the term has reached a critical capacity of meaning. Stress was operationalized around a series of generalized physiological responses that were associated with a deviation from homeostasis. The term was incorporated into anthropological research during the mid-20th century, and further defined in bioarcheological context around a series of skeletal indicators of physiological disruption and disease. Emphases on stress became a predominate area of research in bioarcheology, and eventually, many studies utilized the terms "health" and "stress" interchangeably as part of a broader, problem-oriented approach to evaluating prehistoric population dynamics. Use of the term "health" in relation to skeletal samples is associated with the intellectual history of bioarcheological research, specifically influences from cultural ecology and processualist archeology and remains problematic for two reasons. First, health represents a comprehensive state of well-being that includes physiological status and individual perception, factors that cannot be readily observed in skeletal samples. Second, the categorization of populations into relative levels of health represents a typological approach, however unintentional. This article advocates for the integration of methodological and theoretical advances from human biology and primatology, while simultaneously incorporating the theoretical constructs associated with social epidemiology into bioarcheological research. Such an approach will significantly increase the applicability of bioarcheological findings to anthropological and evolutionary research, and help realize the goal of a truly relevant bioarcheological paradigm. Copyright © 2014 Wiley Periodicals, Inc.

  15. Contributions of 3D Cell Cultures for Cancer Research.

    Science.gov (United States)

    Ravi, Maddaly; Ramesh, Aarthi; Pattabhi, Aishwarya

    2017-10-01

    Cancer cell lines have contributed immensely in understanding the complex physiology of cancers. They are excellent material for studies as they offer homogenous samples without individual variations and can be utilised with ease and flexibility. Also, the number of assays and end-points one can study is almost limitless; with the advantage of improvising, modifying or altering several variables and methods. Literally, a new dimension to cancer research has been achieved by the advent of 3Dimensional (3D) cell culture techniques. This approach increased many folds the ways in which cancer cell lines can be utilised for understanding complex cancer biology. 3D cell culture techniques are now the preferred way of using cancer cell lines to bridge the gap between the 'absolute in vitro' and 'true in vivo'. The aspects of cancer biology that 3D cell culture systems have contributed include morphology, microenvironment, gene and protein expression, invasion/migration/metastasis, angiogenesis, tumour metabolism and drug discovery, testing chemotherapeutic agents, adaptive responses and cancer stem cells. We present here, a comprehensive review on the applications of 3D cell culture systems for these aspects of cancers. J. Cell. Physiol. 232: 2679-2697, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  16. A review of research on the problem of aggression inhibitors (Part II

    Directory of Open Access Journals (Sweden)

    Kalashnikova A.S.

    2014-09-01

    Full Text Available Many researchers in the genesis of the formation of aggressive behavior inextricably consider proagressive and constraining, or inhibiting, aggressive manifestations of structure. The second part of the article deals with a theoretical overview of the problem of aggression inhibitors, which covers the latest Russian and foreign research aimed at studying the individual manifestations of factors deterring aggression. For basis for the analysis we chose classification of personality structures inhibiting aggressive manifestations, proposed by F.S. Safuanov, which includes values, socio-normative, dispositional, emotional, communicative, intellectual restraining structure and psychological protective mechanisms. We made conclusion that the problem of aggression inhibitors currently stands on the threshold of a new phase of the study, that is to provide a holistic model, including illegal aggressive behavior, taking into account not only the socio-psychological characteristics of "aggressor" and his victims, and personality structures that promote and inhibiting aggression, but also covering a wide range of inhibitors of aggression, acting through different psychological mechanisms.

  17. Introducing problem-based learning into research methods teaching: student and facilitator evaluation.

    Science.gov (United States)

    Carlisle, Caroline; Ibbotson, Tracy

    2005-10-01

    The evidence base for the effectiveness of problem-based learning (PBL) has never been substantively established, although PBL is a generally accepted approach to learning in health care curricula. PBL is believed to encourage transferable skills, including problem-solving and team-working. PBL was used to deliver a postgraduate research methods module and a small evaluation study to explore its efficacy was conducted amongst the students (n = 51) and facilitators (n = 6). The study comprised of an evaluation questionnaire, distributed after each themed group of PBL sessions, and a group discussion conducted 4 weeks after the conclusion of the module, which was attended by student representatives and the facilitators. Questionnaire data was analysed using SPSS, and a transcript of the interview was subjected to content analysis. The results indicated that students felt that a PBL approach helped to make the subject matter more interesting to them and they believed that they would retain knowledge for a longer period than if their learning had used a more traditional lecture format. Students also perceived that PBL was effective in its ability to enhance students' understanding of the group process. All those involved in the PBL process reinforced the pivotal role of the facilitator. This study indicates that there is potential for PBL to be used beyond the more usual clinical scenarios constructed for health care professional education and further exploration of its use in areas such as building research capability should be undertaken.

  18. Persisting problems related to race and ethnicity in public health and epidemiology research

    Directory of Open Access Journals (Sweden)

    Jean-Claude Moubarac

    2013-02-01

    Full Text Available A recent and comprehensive review of the use of race and ethnicity in research that address health disparities in epidemiology and public health is provided. First it is described the theoretical basis upon which race and ethnicity differ drawing from previous work in anthropology, social science and public health. Second, it is presented a review of 280 articles published in high impacts factor journals in regards to public health and epidemiology from 2009-2011. An analytical grid enabled the examination of conceptual, theoretical and methodological questions related to the use of both concepts. The majority of articles reviewed were grounded in a theoretical framework and provided interpretations from various models. However, key problems identified include a a failure from researchers to differentiate between the concepts of race and ethnicity; b an inappropriate use of racial categories to ascribe ethnicity; c a lack of transparency in the methods used to assess both concepts; and d failure to address limits associated with the construction of racial or ethnic taxonomies and their use. In conclusion, future studies examining health disparities should clearly establish the distinction between race and ethnicity, develop theoretically driven research and address specific questions about the relationships between race, ethnicity and health. One argue that one way to think about ethnicity, race and health is to dichotomize research into two sets of questions about the relationship between human diversity and health.

  19. Classification of cancerous cells based on the one-class problem approach

    Science.gov (United States)

    Murshed, Nabeel A.; Bortolozzi, Flavio; Sabourin, Robert

    1996-03-01

    One of the most important factors in reducing the effect of cancerous diseases is the early diagnosis, which requires a good and a robust method. With the advancement of computer technologies and digital image processing, the development of a computer-based system has become feasible. In this paper, we introduce a new approach for the detection of cancerous cells. This approach is based on the one-class problem approach, through which the classification system need only be trained with patterns of cancerous cells. This reduces the burden of the training task by about 50%. Based on this approach, a computer-based classification system is developed, based on the Fuzzy ARTMAP neural networks. Experimental results were performed using a set of 542 patterns taken from a sample of breast cancer. Results of the experiment show 98% correct identification of cancerous cells and 95% correct identification of non-cancerous cells.

  20. Use of labelled pesticides in pesticide research studies and problems in the interpretation of the data

    International Nuclear Information System (INIS)

    Sree Ramulu, U.S.; Krishnamoorthy, K.K.

    1980-01-01

    The introduction of labelled pesticides has helped to solve number of problems connected with the formation and degradation of pesticides, factors influencing the above, location of the metabolites in the plants etc. However in most of the studies, the active ingredient has been labelled and diluted and applied at the recommended doses. But the efficacy of the pesticide is modified by the method of formulation, nature of fillers, emulsifiers, solvents, size of droplets etc. Hence the utility as well as the limitations in the use of labelled pesticides in the formulations are discussed. Also due to the variations in the half life of the radioisotopes used for labelling, the use of labelled pesticides for long as well as short duration crops has also been indicated. Autoradiography has become an useful tool in studying the movement of pesticide in the plant, and insects and also locating the regions of high concentration of pesticides and their residues. Though useful, the production of artefacts caused by exudation of cell sap, and other exudates, thickness of samples, increasing time of contact in the case of low energy radioisotope labelled compounds etc. have prevented the use of this technique on a wide scale. The problems in the preparation of autoradiographs of the plant specimens treated with labelled pesticides are also discussed. (author)

  1. Modern problems of DNA repair in mammalian cells and some unsettled questions

    International Nuclear Information System (INIS)

    Gaziev, A.I.

    1978-01-01

    A comparison of DNA repair process in the cells of mammals and E. coli revealed no principal differences in the enzymic mechanisms of DNA repair in the cells of higher and lower organisms. It has been found that when given is the same number of impairments in the section of DNA chain in the cells of mammals and bacteria the regeneration in the former occurs more slowly than in the latter. Low rate elimination of impairments of DNA in the cells of mammals is due to a more complex intracellular and permolecular organization. It is stressed that the investigation into the mechanisms of fixing impairments in case of postreplication DNA repair is a very important and unresolved problem, especially in terms of radiation mutagenesis and cancerogenesis. Much thought is given to the problem of repairing double stranded ruptures of DNA. It is proposed that DNA repair should be considered not only in terms of functioning of enzymes in DNA metabolism, but also permolecular organization of genome in the cell

  2. Broadening participation in community problem solving: a multidisciplinary model to support collaborative practice and research.

    Science.gov (United States)

    Lasker, Roz D; Weiss, Elisa S

    2003-03-01

    Over the last 40 years, thousands of communities-in the United States and internationally-have been working to broaden the involvement of people and organizations in addressing community-level problems related to health and other areas. Yet, in spite of this experience, many communities are having substantial difficulty achieving their collaborative objective, and many funders of community partnerships and participation initiatives are looking for ways to get more out of their investment. One of the reasons we are in this predicament is that the practitioners and researchers who are interested in community collaboration come from a variety of contexts, initiatives, and academic disciplines, and few of them have integrated their work with experiences or literatures beyond their own domain. In this article, we seek to overcome some of this fragmentation of effort by presenting a multidisciplinary model that lays out the pathways by which broadly participatory processes lead to more effective community problem solving and to improvements in community health. The model, which builds on a broad array of practical experience as well as conceptual and empirical work in multiple fields, is an outgrowth of a joint-learning work group that was organized to support nine communities in the Turning Point initiative. Following a detailed explication of the model, the article focuses on the implications of the model for research, practice, and policy. It describes how the model can help researchers answer the fundamental effectiveness and "how-to" questions related to community collaboration. In addition, the article explores differences between the model and current practice, suggesting strategies that can help the participants in, and funders of, community collaborations strengthen their efforts.

  3. Studies on the target cell problem in leukemogenesis induced by N-nitroso-N-methyl urea

    International Nuclear Information System (INIS)

    Seidel, G.; Fey, F.

    1979-01-01

    After i.p. application of 14 C-nitrosomethylurea (NMU), mice were killed at different periods and the 14 C activity in various organs was determined by scintillation counting and by autoradiography. Contrary to expectations, the bone marrow showed a significantly higher activity than the thymus, which is the supposed target organ for the lymphatic leukemogenesis. The specificity was secured by examinations of the proliferation kinetics. The radioautographic results of the bone marrow favorize the lymphatic cells as the target for NMU. The target cell problem is discussed in respect of thymectomy examinations and recent results on nude mice. With high probability the thymus is not essential for lymphatic leukemogenesis. (author)

  4. Temas e problemas nos projetos de pesquisa Thems and problems in research projects

    Directory of Open Access Journals (Sweden)

    Alvaro Bianchi

    2007-05-01

    Full Text Available O ponto de partida da atividade cienífica é o espanto e a admiração perante o desconhecido que provocam a imaginação científica, conduzindo o investigador à escolha de uma dada temática. Relevância para o mundo real e contribuição para um campo específico do conhecimento são, aqui, critérios de definição temática. Para o cientista, o tema de pesquisa é o terreno sobre o qual ele formulará problemas relevantes de investigação capazes de suprir lacunas em nossos conhecimentos. Tais problemas devem ser construídos de tal maneira que suas soluções não só esclareçam aspectos até então não explicados do tema, como apontem para novos problemas, ou seja, futuras investigações científicas. Constatando a crescente exigência de monografias de conclusão de curso para a obtenção de título nos cursos de graduação, o artigo procura construir um guia para a definição de temas e a formulação de pesquisa nas ciências humanas. Para tanto, procederá a uma reconstrução metodológica do caminho percorrido por C. Wright Mills em sua obra The power elite. Palavras-chave: Metodologia da pesquisa. Pesquisa cientifica. Problemas científicos. The starting point of the scientific activity is the puzzle and admiration in face of the unknown, which, certainly, will challenge the scientific imagination, leading the researcher in the choice of a certain theme. Relevance for the real world and contribution for a specific field of knowledge are the basic criteria for the thematic definition used here. For the scientist, the theme of the research is the base to formulate relevant research problems able to fill in the gaps of our knowledge. Such problems must be built in such a way that is solutions will not only clarify some aspects of the theme that remained not explained but also provide a path for new questions, i.e., for new scientifc researches to come. As there is a growing demand of under-graduate monographs for

  5. CONCEPTUALIZATION OF IDEAS OF PSYCHOLOGICAL SAFETY IN SPORTS: PROBLEMS OF EXPERIMENTAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Yulia Vladimirovna Vardanyan

    2013-09-01

    Full Text Available This article is devoted to the research of the concept “psychological safety in sports”. On the basis of analysis of ideas about psychological safety in sports and their representation in printed or verbal form the necessity of overcoming the fragmentation and lack of system is substantiated. The authors state that one and the same sports situation can constructively or destructively affect the psychological safety of direct or indirect participants of sports events. In this context, it is important to create the psycholinguistic basis of experimental research of psychological safety in sports. Great attention is paid to systematization of the content of the concept “psychological safety in sports”. The created models of words and expressions that convey ideas about this phenomenon are of particular value. In the structure of the concept the dominant meanings, expressed in the nucleus, and additional meanings, related to the periphery of the concept are distinguished.Purpose: to explore the ideas of psychological safety in sports and their representation in printed or verbal form; to determine ways of overcoming the conceptual psycholinguistic problems in the process of experimental research of psychological safety in sports; to create the model of words and expressions which are used to verbalize the concept “psychological safety in sports”.Methodology: theoretical analysis of psychological and linguistic literature, creation of the psycholinguistic basis of experimental research, modeling of the conceptual ideas of psychological safety in sports.Results: psycholinguistic basis of experimental research of psychological safety in sports, the model of content and structure of the corresponding concept.Practical implications: Pedagogical Psychology, Sports Psychology, Philology, Psycholinguistics.DOI: http://dx.doi.org/10.12731/2218-7405-2013-8-11

  6. Radiobiological research for improving cancer therapy in India: rationale, problems and prospects

    International Nuclear Information System (INIS)

    Kalia, Vijay K.; Shobha, A.G.; KaIia, Anita; Saxena, Amit

    2012-01-01

    Cancer is emerging as a very important health hazard in India. According to recent studies by the Indian Council of Medical Research, about 2.25 million patients are presently suffering from different types of cancer in India. Approximately one million new cases are diagnosed, and nearly 0.3 million deaths occur every year on account of this disease. About 2/3rd of the cancers are at an advanced stage at the time of diagnosis. However, the allocation of funds for healthcare in India to support the research efforts for developing more potent radio-chemotherapy protocols for cancer treatment is too little. Studies by the W.H.O. have estimated that less developed countries including India use less than 5% of world resources destined for cancer control. It follows from the above discussions that it is imperative to further encourage and diversify the radiobiological research in India. This can be achieved by creating radiobiological research facilities, mainly in all the cancer centers and post graduate medical institutions, and further expanding the upcoming laboratories in the universities such as Bikaner. Collaborative research programs between laboratories at different centers could facilitate systematic evaluation of various pharmacological agents and neutraceuticals for potential application for treatment of different cancers. Our studies on combination of radiation with temozolomide and certain adjuvants with selective effects on brain tumour cells will be very briefly discussed in this presentation. Finally the possible administrative set up and multi dimensional collaborations for cost effective utilization of existing resources to further augment radiation biology research will also be discussed

  7. Prostate Cancer Stem-Like Cells | Center for Cancer Research

    Science.gov (United States)

    Prostate cancer is the third leading cause of cancer-related death among men, killing an estimated 27,000 men each year in the United States. Men with advanced prostate cancer often become resistant to conventional therapies. Many researchers speculate that the emergence of resistance is due to the presence of cancer stem cells, which are believed to be a small subpopulation

  8. Plant cell engineering: current research, application and future prospects

    International Nuclear Information System (INIS)

    Wang Xunqing; Liu Luxiang

    2008-01-01

    This paper reviewed the current status of basic research in plant cell engineering, highlighted the application of embryo culture, double haploid (DH) technology, protoplast culture and somatic hybridization, somaclonal variation, rapid propagation, and bio-products production of plant-origin, and t he prospects. (authors)

  9. Some applications of nanotechnologies in stem cells research

    Czech Academy of Sciences Publication Activity Database

    Belicchi, M.; Cancedda, R.; Cedola, A.; Fiori, F.; Gavina, M.; Giuliani, A.; Komlev, V. S.; Lagomarsino, S.; Mastrogiacomo, M.; Renghini, C.; Rustichelli, F.; Syková, Eva; Torrente, Y.

    2009-01-01

    Roč. 165, č. 3 (2009), s. 139-147 ISSN 0921-5107 Institutional research plan: CEZ:AV0Z50390512 Keywords : imaging techniques * stem cells * nanoparticles Subject RIV: FH - Neurology Impact factor: 1.715, year: 2009

  10. Managing Ethical Problems in Qualitative Research Involving Vulnerable Populations, Using a Pilot Study

    Directory of Open Access Journals (Sweden)

    Evalina van Wijk RN, PhD

    2013-02-01

    Full Text Available The purpose of the researcher's study was to examine the meaning that intimate partners of female rape victims attached to their lived experiences after the rape. The conduct of qualitative research concerning non-offending partners of female rape victims, however, often involves multifaceted ethical and practical challenges, which can be managed through the use of pilot studies. The pilot study described in this report had three objectives. The first was to pretest and refine the proposed method for locating, accessing, and recruiting intimate partners of female rape victims, within the first two weeks after the rape, for participation in a six-month longitudinal study. The second objective was to identify and prevent all possible risk factors in the proposed recruitment and data collection methods that could harm the participants' safety during the main study. The third objective was to determine the feasibility of the main study, in terms of the limited financial and human resources available. The pilot phase was valuable in identifying ethical and methodological problems during the recruitment of participants and collection of data. It allowed for methodological adjustments prior to the main study and confirmed the feasibility of the overall research design. A pilot, pretesting phase is therefore seen as an essential component of a qualitative study involving a vulnerable population.

  11. Problem-based learning in pre-clinical medical education: 22 years of outcome research.

    Science.gov (United States)

    Hartling, Lisa; Spooner, Carol; Tjosvold, Lisa; Oswald, Anna

    2010-01-01

    To conduct a systematic review of problem-based learning (PBL) in undergraduate, pre-clinical medical education. A research librarian developed comprehensive search strategies for MEDLINE, PSYCINFO, and ERIC (1985-2007). Two reviewers independently screened search results and applied inclusion criteria. Studies were included if they had a comparison group and reported primary data for evaluative outcomes. One reviewer extracted data and a second reviewer checked data for accuracy. Two reviewers independently assessed methodological quality. Quantitative synthesis was not performed due to heterogeneity. A qualitative review with detailed evidence tables is provided. Thirty unique studies were included. Knowledge acquisition measured by exam scores was the most frequent outcome reported; 12 of 15 studies found no significant differences. Individual studies demonstrated either improved clerkship (N = 3) or residency (N = 1) performance, or benefits on some clinical competencies during internships for PBL (N = 1). Three of four studies found some benefits for PBL when evaluating diagnostic accuracy. Three studies found few differences of clinical (or practical) importance on the impact of PBL on practicing physicians. Twenty-two years of research shows that PBL does not impact knowledge acquisition; evidence for other outcomes does not provide unequivocal support for enhanced learning. Work is needed to determine the most appropriate outcome measures to capture and quantify the effects of PBL. General conclusions are limited by methodological weaknesses and heterogeneity across studies. The critical appraisal of previous studies, conducted as part of this review, provides direction for future research in this area.

  12. A top priority problem of national radiation protection - proper disposal of research reactor spent fuel

    International Nuclear Information System (INIS)

    Marinkovic, N.; Matausek, M.V.; Jovic, V.

    1997-01-01

    The paper presents basic facts about RA research reactor at the Vinca Institute. The present state of the RA reactor spent fuel storage pool appears to be a serious safety and radiological problem, which must be solved urgently, independent of the decision about the future status of the reactor itself. The following paragraphs describe current activities on improving storage conditions of the research reactor RA spent fuel. Activities performed so far, concerning identification and improvement of the spent fuel storage conditions are presented. These are verification of radiation protection measures, radiological and chemical analyses, visual inspection and photographing, safety analyses and nuclear criticality studies.A project for long-term solution of the research reactor spent fuel storage is proposed. In order to minimise further corrosion and establish strict control of all the relevant technological parameters of the utility, improvement of conditions for disposal of the fuel in the existing storage, is foreseen in the first phase. New dry storage for long-term storing of the spent fuel should be built during the second phase of the project. Particular attention is paid to the activities related to radiation protection and waste treatment, starting from standard monitoring and control, radiological analyses, regulations and legislation, to complicated handling of high level radioactive waste. (authors)

  13. Efficient Parallel Sorting for Migrating Birds Optimization When Solving Machine-Part Cell Formation Problems

    Directory of Open Access Journals (Sweden)

    Ricardo Soto

    2016-01-01

    Full Text Available The Machine-Part Cell Formation Problem (MPCFP is a NP-Hard optimization problem that consists in grouping machines and parts in a set of cells, so that each cell can operate independently and the intercell movements are minimized. This problem has largely been tackled in the literature by using different techniques ranging from classic methods such as linear programming to more modern nature-inspired metaheuristics. In this paper, we present an efficient parallel version of the Migrating Birds Optimization metaheuristic for solving the MPCFP. Migrating Birds Optimization is a population metaheuristic based on the V-Flight formation of the migrating birds, which is proven to be an effective formation in energy saving. This approach is enhanced by the smart incorporation of parallel procedures that notably improve performance of the several sorting processes performed by the metaheuristic. We perform computational experiments on 1080 benchmarks resulting from the combination of 90 well-known MPCFP instances with 12 sorting configurations with and without threads. We illustrate promising results where the proposal is able to reach the global optimum in all instances, while the solving time with respect to a nonparallel approach is notably reduced.

  14. What's missing? Discussing stem cell translational research in educational information on stem cell "tourism".

    Science.gov (United States)

    Master, Zubin; Zarzeczny, Amy; Rachul, Christen; Caulfield, Timothy

    2013-01-01

    Stem cell tourism is a growing industry in which patients pursue unproven stem cell therapies for a wide variety of illnesses and conditions. It is a challenging market to regulate due to a number of factors including its international, online, direct-to-consumer approach. Calls to provide education and information to patients, their families, physicians, and the general public about the risks associated with stem cell tourism are mounting. Initial studies examining the perceptions of patients who have pursued stem cell tourism indicate many are highly critical of the research and regulatory systems in their home countries and believe them to be stagnant and unresponsive to patient needs. We suggest that educational material should include an explanation of the translational research process, in addition to other aspects of stem cell tourism, as one means to help promote greater understanding and, ideally, curb patient demand for unproven stem cell interventions. The material provided must stress that strong scientific research is required in order for therapies to be safe and have a greater chance at being effective. Through an analysis of educational material on stem cell tourism and translational stem cell research from patient groups and scientific societies, we describe essential elements that should be conveyed in educational material provided to patients. Although we support the broad dissemination of educational material on stem cell translational research, we also acknowledge that education may simply not be enough to engender patient and public trust in domestic research and regulatory systems. However, promoting patient autonomy by providing good quality information to patients so they can make better informed decisions is valuable in itself, irrespective of whether it serves as an effective deterrent of stem cell tourism. © 2013 American Society of Law, Medicine & Ethics, Inc.

  15. Research Progress of Photoanodes for Quantum Dot Sensitized Solar Cells

    Directory of Open Access Journals (Sweden)

    LI Zhi-min

    2017-08-01

    Full Text Available This paper presents the development status and tendency of quantum dot sensitized solar cells. Photoanode research progress and its related technologies are analyzed in detail from the three ways of semiconductor thin films, quantum dot co-sensitization and quantum dot doping, deriving from the approach that the conversion efficiency can be improved by photoanode modification for quantum dot sensitized solar cells. According to the key factors which restrict the cell efficiency, the promising future development of quantum dot sensitized solar cells is proposed,for example,optimizing further the compositions and structures of semiconductor thin films for the photoanodes, exploring new quantum dots with broadband absorption and developing high efficient techniques of interface modification.

  16. The Usefulness of Qualitative and Quantitative Approaches and Methods in Researching Problem-Solving Ability in Science Education Curriculum

    Science.gov (United States)

    Eyisi, Daniel

    2016-01-01

    Research in science education is to discover the truth which involves the combination of reasoning and experiences. In order to find out appropriate teaching methods that are necessary for teaching science students problem-solving skills, different research approaches are used by educational researchers based on the data collection and analysis…

  17. Research on ZnO/Si heterojunction solar cells

    Science.gov (United States)

    Chen, Li; Chen, Xinliang; Liu, Yiming; Zhao, Ying; Zhang, Xiaodan

    2017-06-01

    We put forward an n-ZnO/p-Si heterojunction solar cell model based on AFORS-HET simulations and provide experimental support in this article. ZnO:B (B-doped ZnO) thin films deposited by metal-organic chemical vapor deposition (MOCVD) are planned to act as electrical emitter layer on p-type c-Si substrate for photovoltaic applications. We investigate the effects of thickness, buffer layer, ZnO:B affinity and work function of electrodes on performances of solar cells through computer simulations using AFORS-HET software package. The energy conversion efficiency of the ZnO:B(n)/ZnO/c-Si(p) solar cell can achieve 17.16% ({V}{oc}: 675.8 mV, {J}{sc}: 30.24 mA/cm2, FF: 83.96%) via simulation. On a basis of optimized conditions in simulation, we carry out some experiments, which testify that the ZnO buffer layer of 20 nm contributes to improving performances of solar cells. The influences of growth temperature, thickness and diborane (B2H6) flow rates are also discussed. We achieve an appropriate condition for the fabrication of the solar cells using the MOCVD technique. The obtained conversion efficiency reaches 2.82% ({V}{oc}: 294.4 mV, {J}{sc}: 26.108 mA/cm2, FF: 36.66%). Project supported by the State Key Development Program for Basic Research of China (Nos. 2011CBA00706, 2011CBA00707), the Tianjin Applied Basic Research Project and Cutting-Edge Technology Research Plan (No. 13JCZDJC26900), the Tianjin Major Science and Technology Support Project (No. 11TXSYGX22100), the National High Technology Research and Development Program of China (No. 2013AA050302), and the Fundamental Research Funds for the Central Universities (No. 65010341).

  18. Benchmark problem for IAEA coordinated research program (CRP-3) on GCR afterheat removal. 1

    International Nuclear Information System (INIS)

    Takada, Shoji; Shiina, Yasuaki; Inagaki, Yoshiyuki; Hishida, Makoto; Sudo, Yukio

    1995-08-01

    In this report, detailed data which are necessary for the benchmark analysis of International Atomic Energy Agency (IAEA) Coordinated Research Program (CRP-3) on 'Heat Transport and Afterheat Removal for Gas-cooled Reactors under Accident Conditions' are described concerning about the configuration and sizes of the cooling panel test apparatus, experimental data and thermal properties. The test section of the test apparatus is composed of pressure vessel (max. 450degC) containing an electric heater (max. 100kW, 600degC) and cooling panels surrounding the pressure vessel. Gas pressure is varied from vacuum to 1.0MPa in the pressure vessel. Two experimental cases are selected as benchmark problems about afterheat removal of HTGR, described as follows, The experimental conditions are vacuum inside the pressure vessel and heater output 13.14kW, and helium gas pressure 0.73MPa inside the pressure vessel and heater output 28.79kW. Benchmark problems are to calculate temperature distributions on the outer surface of pressure vessel and heat transferred to the cooling panel using the experimental data. The analytical result of temperature distribution on the pressure vessel was estimated +38degC, -29degC compared with the experimental data, and analytical result of heat transferred from the surface of pressure vessel to the cooling panel was estimated max. -11.4% compared with the experimental result by using the computational code -THANPACST2- of JAERI. (author)

  19. Assessing Risks to Wildlife Populations from Multiple Stressors: Overview of the Problem and Research Needs.

    Directory of Open Access Journals (Sweden)

    Wayne R. Munns, Jr.

    2006-06-01

    Full Text Available Wildlife populations are experiencing increasing pressure from human-induced changes in the landscape. Stressors including agricultural and urban land use, introduced invasive and exotic species, nutrient enrichment, direct human disturbance, and toxic chemicals directly or indirectly influence the quality and quantity of habitat used by terrestrial and aquatic wildlife. Governmental agencies such as the U.S. Environmental Protection Agency are required to assess risks to wildlife populations, in its broadest definition, that result from exposure to these stressors, yet considerable uncertainty exists with respect to how such assessments should be conducted. This uncertainty is compounded by questions concerning the interactive effects of co-occurring stressors, appropriate spatial scales of analysis, extrapolation of response data among species and from organisms to populations, and imperfect knowledge and use of limited data sets. Further, different risk problems require varying degrees of sophistication, methodological refinement, and data quality. These issues suggest a number of research needs to improve methods for wildlife risk assessments, including continued development of population dynamics models to evaluate the effects of multiple stressors at varying spatial scales, methods for extrapolating across endpoints and species with reasonable confidence, stressor-response relations and methods for combining them in predictive and diagnostic assessments, and accessible data sets describing the ecology of terrestrial and aquatic species. Case study application of models and methods for assessing wildlife risk will help to demonstrate their strengths and limitations for solving particular risk problems.

  20. The rising tide of ocean diseases: Unsolved problems and research priorities

    Science.gov (United States)

    Harvell, Drew; Aronson, Richard; Baron, Nancy; Connell, Joseph; Dobson, Andrew P.; Ellner, Steve; Gerber, Leah R.; Kim, Kiho; Kuris, Armand M.; McCallum, Hamish; Lafferty, Kevin D.; McKay, Bruce; Porter, James; Pascual, Mercedes; Smith, Garriett; Sutherland, Katherine; Ward, Jessica

    2004-01-01

    New studies have detected a rising number of reports of diseases in marine organisms such as corals, molluscs, turtles, mammals, and echinoderms over the past three decades. Despite the increasing disease load, microbiological, molecular, and theoretical tools for managing disease in the world's oceans are under-developed. Review of the new developments in the study of these diseases identifies five major unsolved problems and priorities for future research: (1) detecting origins and reservoirs for marine diseases and tracing the flow of some new pathogens from land to sea; (2) documenting the longevity and host range of infectious stages; (3) evaluating the effect of greater taxonomic diversity of marine relative to terrestrial hosts and pathogens; (4) pinpointing the facilitating role of anthropogenic agents as incubators and conveyors of marine pathogens; (5) adapting epidemiological models to analysis of marine disease.

  1. Legal problem research on surrogacy%代孕问题法律研究

    Institute of Scientific and Technical Information of China (English)

    杨晶

    2015-01-01

    Along with social progress and development, the application of surrogacy is increasingly frequent. It overturns original reproductive concept and way, at the same time through the existing legal system. Conduct legal research and legal problems of surrogacy regulation, is quite necessary.%随着社会的进步和发展,代孕这一人类辅助生殖技术在生活中的应用也日渐频繁.它颠覆了原有的生殖观念和方式,同时冲击着现有的法律制度.对代孕问题进行法律研究和法律规制,相当必要.

  2. Power Quality Problems Mitigation using Dynamic Voltage Restorer in Egypt Thermal Research Reactor (ETRR-2)

    International Nuclear Information System (INIS)

    Kandil, T.; Ayad, N.M.; Abdel Haleam, A.; Mahmoud, M.

    2013-01-01

    Egypt thermal research reactor (ETRR-2) was subjected to several Power Quality Problems such as voltage sags/swells, harmonics distortion, and short interruption. ETRR-2 encompasses a wide range of loads which are very sensitive to voltage variations and this leads to several unplanned shutdowns of the reactor due to trigger of the Reactor Protection System (RPS). The Dynamic Voltage Restorer (DVR) has recently been introduced to protect sensitive loads from voltage sags and other voltage disturbances. It is considered as one of the most efficient and effective solution. Its appeal includes smaller size and fast dynamic response to the disturbance. This paper describes a proposal of a DVR to improve power quality in ETRR-2 electrical distribution systems . The control of the compensation voltage is based on d-q-o algorithm. Simulation is carried out by Matlab/Simulink to verify the performance of the proposed method

  3. Researches on Problems in College Students'Grammar Learning and Countermeasures%Researches on Problems in College Students' Grammar Learning and Countermeasures

    Institute of Scientific and Technical Information of China (English)

    廖芳

    2016-01-01

    Grammar is the guiding rules of language, and a good mastery of grammar is the basis of English learning. This paper starts from the problems in college students' current grammar learning and put forwards some strategies to improve their English grammar.

  4. HANARO Neutron Radiography Facility and Fuel Cell Research

    International Nuclear Information System (INIS)

    Kim, Taejoo

    2013-01-01

    Fuel cell which generates electric energy from hydrogen and oxygen is one of noticed renewable energy system because this has high efficiency and free from CO 2 . Especially, PEMFC (Polymer Electrolyte Membrane Fuel Cell) is focused by automotive companies because PEMFC, which has high power rate per volume and low operating temperature (60∼80), is suited due to the compact design and short start-up time. The water management is one of the most critical issues for fuel cell commercialization. In order to make a proper scheme for water management, thein formation of water distribution and behavior is very important. Neutron imaging is the best method to visualize the water at fuel cell and has been applied worldwide with qualitative and quantitative results. Because the NRF has large beam size (350Χ450mm 2 ) and relatively high neutron flux (2Χ107 n/cm 2 sec), it is suitable for large scale fuel cell research. Neutron imaging technique was used to investigate the water distribution and behavior in PEMFC under different operating conditions. The NRF has contributed the improvement of fuel cell performance and is one of the best choices for fuel cell study

  5. Pluripotent Stem Cells in Research and Treatment of Hemoglobinopathies

    Science.gov (United States)

    Arora, Natasha; Daley, George Q.

    2012-01-01

    Pluripotent stem cells (PSCs) hold great promise for research and treatment of hemoglobinopathies. In principle, patient-specific induced pluripotent stem cells could be derived from a blood sample, genetically corrected to repair the disease-causing mutation, differentiated into hematopoietic stem cells (HSCs), and returned to the patient to provide a cure through autologous gene and cell therapy. However, there are many challenges at each step of this complex treatment paradigm. Gene repair is currently inefficient in stem cells, but use of zinc finger nucleases and transcription activator-like effector nucleases appear to be a major advance. To date, no successful protocol exists for differentiating PSCs into definitive HSCs. PSCs can be directly differentiated into primitive red blood cells, but not yet in sufficient numbers to enable treating patients, and the cost of clinical scale differentiation is prohibitively expensive with current differentiation methods and efficiencies. Here we review the progress, promise, and remaining hurdles in realizing the potential of PSCs for cell therapy. PMID:22474618

  6. Research and development for evaluation system of solar cell

    Energy Technology Data Exchange (ETDEWEB)

    1986-08-01

    In order to evaluate the performance and capability of solar cell properly and impartially, the evaluation systems for the performance and reliability have been assured. The results are as follows. 1. Development for performance evaluation method; (1) The international comparisons of standard solar cell calibration methods and our method has been assured to be mostly near to the average value. (2) Experimental solar cell has been made and the indoors and outdoors evaluation of solar cell module have become to be possible with same accuracy. (3) As the spectro-radiometer of high performance have been developed, the measurements of the output of the solar cell module have become possible, monitering spectrum of wide range of natural solar beam. (4) With use of several kinds of standard solar cell, measurement errors have been assured. (5) As for nominal operating cell temperature of module, experimental researches have been done indoors and outdoors and the diffeneces have been assured. 2. Development of reliability evaluation method; (1) In outdoor exposure test, the basic data of the accelerating degradation test have been accumulated and it has been assured that the degradation of crystal type is few. (2) By the acceleration degradation test with use of weathermeter, and temperature and humidity cycling test device, the proceses of degradation have been assured. (3) In the processes of enviromental tests and mechanical strength tests, remarkable degradation has not been recognized.(1 tab)

  7. Problem solving in physics: research review, analysis, and a methodological proposal

    Directory of Open Access Journals (Sweden)

    Maria Helena Fávero

    2001-05-01

    Full Text Available This article presents a literature review on problem solving in Physics based on the scientific articles published in periodicals of the related field of study. The articles considered for this study were published in the period between the end of the 70`s until 1999. A categorization of the publications , according to the issue investigated, the theoretical background used, the research method adopted, the results and conclusions are considered as a starting point in order to present a research profile of the field of study. Next, this profile is discussed and analyzed , pointing out the convergent aspects that characterize the field. Taking this analysis into account, the following thesis (based on Fávero`s proposal, 2000 is defended: in order to generate tools for the teaching practice of Physics through the study of problem solving, a method that substitutes the idea of knowledge transmission in the communication processes that takes place in the classroom should be developed. This method should comprise the idea of interlocution (Vion, 2000 which focuses on social interaction as a means to reveal metacognitive regulations of the subjects, pariticipants in the process, and their development of awareness in relation to a conceptual field (Vergnaud, 1990 – Physics, in this case. The analysis of these processes considers the verbal exchanges among the subjects (Bromberg & Chabrol, 1999 developed in the situation of interaction. This thesis is supported by the articulation of concepts in Psychology, including its interface with linguistics, such as conceptual field, development of awareness and acts of speech, which are reconsidered in this study.

  8. HESS Opinions "Integration of groundwater and surface water research: an interdisciplinary problem?"

    Science.gov (United States)

    Barthel, R.

    2014-07-01

    Today there is a great consensus that water resource research needs to become more holistic, integrating perspectives of a large variety of disciplines. Groundwater and surface water (hereafter: GW and SW) are typically identified as different compartments of the hydrological cycle and were traditionally often studied and managed separately. However, despite this separation, these respective fields of study are usually not considered to be different disciplines. They are often seen as different specializations of hydrology with a different focus yet similar theory, concepts, and methodology. The present article discusses how this notion may form a substantial obstacle in the further integration of GW and SW research and management. The article focuses on the regional scale (areas of approximately 103 to 106 km2), which is identified as the scale where integration is most greatly needed, but ironically where the least amount of fully integrated research seems to be undertaken. The state of research on integrating GW and SW research is briefly reviewed and the most essential differences between GW hydrology (or hydrogeology, geohydrology) and SW hydrology are presented. Groundwater recharge and baseflow are used as examples to illustrate different perspectives on similar phenomena that can cause severe misunderstandings and errors in the conceptualization of integration schemes. The fact that integration of GW and SW research on the regional scale necessarily must move beyond the hydrological aspects, by collaborating with the social sciences and increasing the interaction between science and society in general, is also discussed. The typical elements of an ideal interdisciplinary workflow are presented and their relevance with respect to the integration of GW and SW is discussed. The overall conclusions are that GW hydrology and SW hydrogeology study rather different objects of interest, using different types of observation, working on different problem settings

  9. Thin Film CIGS Solar Cells, Photovoltaic Modules, and the Problems of Modeling

    Directory of Open Access Journals (Sweden)

    Antonino Parisi

    2013-01-01

    Full Text Available Starting from the results regarding a nonvacuum technique to fabricate CIGS thin films for solar cells by means of single-step electrodeposition, we focus on the methodological problems of modeling at cell structure and photovoltaic module levels. As a matter of fact, electrodeposition is known as a practical alternative to costly vacuum-based technologies for semiconductor processing in the photovoltaic device sector, but it can lead to quite different structural and electrical properties. For this reason, a greater effort is required to ensure that the perspectives of the electrical engineer and the material scientist are given an opportunity for a closer comparison and a common language. Derived parameters from ongoing experiments have been used for simulation with the different approaches, in order to develop a set of tools which can be used to put together modeling both at single cell structure and complete module levels.

  10. A hybrid approach to solving the problem of design of nuclear fuel cells

    International Nuclear Information System (INIS)

    Montes T, J. L.; Perusquia del C, R.; Ortiz S, J. J.; Castillo, A.

    2015-09-01

    An approach to solving the problem of fuel cell design for BWR power reactor is presented. For this purpose the hybridization of a method based in heuristic knowledge rules called S15 and the advantages of a meta-heuristic method is proposed. The synergy of potentialities of both techniques allows finding solutions of more quality. The quality of each solution is obtained through a multi-objective function formed from the main cell parameters that are provided or obtained during the simulation with the CASMO-4 code. To evaluate this alternative of solution nuclear fuel cells of reference of nuclear power plant of Laguna Verde were used. The results show that in a systematic way the results improve when both methods are coupled. As a result of the hybridization process of the mentioned techniques an improvement is achieved in a range of 2% with regard to the achieved results in an independent way by the S15 method. (Author)

  11. Under-Researched Demographics: Heavy Episodic Drinking and Alcohol-Related Problems Among Asian Americans.

    Science.gov (United States)

    Iwamoto, Derek Kenji; Kaya, Aylin; Grivel, Margaux; Clinton, Lauren

    2016-01-01

    Asian Americans represent the fastest- growing population in the United States (Le 2010). At the same time, there is evidence that problematic drinking rates are increasing among young-adult Asian Americans (Grant et al. 2004). Accordingly, it is essential to understand the etiological determinants and mechanisms of risk that may help explain this growth in problematic alcohol use among this group. The high prevalence of the ALDH2*2 and ADH1B*2 alleles in a large percentage of Asian subgroups has been studied as a potential protective factors against alcohol abuse, yet some individuals who possess these genes still engage in problematic alcohol use (Wall et al. 2001). Other social and psychological factors may account for this discrepancy. Thus, some factors, such as negative physiological alcohol expectancies, are protective against alcohol abuse in this population (Hendershot et al. 2009). Sociocultural factors such as acculturation and nativity also may help explain drinking patterns among this group. The literature suggests that vast and significant within-group differences exist among Asian Americans, such that individuals who were born in the United States and/or are more acculturated are at elevated risk for alcohol abuse and related problems (Hahm et al. 2003). Differences also have been observed among Asian-American ethnic subgroups, with some groups (e.g., Japanese, Korean, and multi-Asian Americans) reporting higher rates of drinking compared with others (e.g., Chinese and Vietnamese Americans) (Iwamoto et al. 2012). Furthermore, Asian Americans who report higher levels of depressive symptoms, psychological distress, and perceived discrimination seem to be at a heightened risk for abusing alcohol (Iwamoto et al. 2011a; Nishimura et al. 2005; Yoo et al. 2010). Finally, an emerging body of research examining gender-relevant factors, including feminine and masculine norms, may help explain within-group differences among Asian-American women and men. Thus

  12. [Mechanism research on the lupeol treatment on MCF-7 breast cancer cells based on cell metabonomics].

    Science.gov (United States)

    Shi, Dongdong; Kuang, Yuanyuan; Wang, Guiming; Peng, Zhangxiao; Wang, Yan; Yan, Chao

    2014-03-01

    The objective of this research is to investigate the suppressive effects of lupeol on MCF-7 breast cancer cells, and explore its mechanism on inhibiting the proliferation of MCF-7 cells based on cell metabonomics and cell cycle. Gas chromatography-mass spectrometry (GC-MS) was used in the cell metabonomics assay to identify metabolites of MCF-7 cells and MCF-7 cells treated with lupeol. Then, orthogonal partial least squares discriminant analysis (OPLS-DA) was used to process the metabolic data and model parameters of OPLS-DA were as follows: R2Ycum = 0.988, Q2Ycum = 0.964, which indicated that these two groups could be distinguished clearly. The metabolites (VIP (variable importance in the projection) > 1) were analyzed by t-test, and finally, metabolites (t metabonomics.

  13. Materials of research-practical conference dedicated to 70-anniversary of sanitation, hygiene and occupational diseases research institute 'Actual problems of hygiene, sanitation and ecology'

    International Nuclear Information System (INIS)

    Iskandarov, T.I.; Kamil'dzhanov, A.Kh.

    2004-01-01

    The Research-practical conference dedicated to 70-anniversary of sanitation, hygiene and occupational diseases research institute 'Actual problems of hygiene, sanitation and ecology' was held on 2004 in Tashkent, Uzbekistan. Specialists discussed various aspects of actual problems of sanitation, hygiene, occupational diseases and ecology. They discussed also some aspects of radiology and nuclear medicine, radiation protection and dosimetry, radiation and other environmental pollutant effect on living organisms and biological materials. More than 250 talks were presented in the meeting. (k.m.)

  14. WebMail versus WebApp: Comparing Problem-Based Learning Methods in a Business Research Methods Course

    Science.gov (United States)

    Williams van Rooij, Shahron

    2007-01-01

    This study examined the impact of two Problem-Based Learning (PBL) approaches on knowledge transfer, problem-solving self-efficacy, and perceived learning gains among four intact classes of adult learners engaged in a group project in an online undergraduate business research methods course. With two of the classes using a text-only PBL workbook…

  15. Training Interdisciplinary "Wicked Problem" Solvers: Applying Lessons from HERO in Community-Based Research Experiences for Undergraduates

    Science.gov (United States)

    Cantor, Alida; DeLauer, Verna; Martin, Deborah; Rogan, John

    2015-01-01

    Management of "wicked problems", messy real-world problems that defy resolution, requires thinkers who can transcend disciplinary boundaries, work collaboratively, and handle complexity and obstacles. This paper explores how educators can train undergraduates in these skills through applied community-based research, using the example of…

  16. Causes of Indoor Air Quality Problems in Schools: Summary of Scientific Research

    Energy Technology Data Exchange (ETDEWEB)

    Bayer, C.W.

    2001-02-22

    chemical sensitivity versus bioaerosols (aerosolized microbes), or the contribution of the microorganisms to the chemical sensitivities, is not yet understood. If the inhabitants of a building exhibit similar symptoms of a clearly defined disease with a nature and time of onset that can be related to building occupancy, the disease is generally referred to as ''building-related illness.'' Once the SBS has been allowed to elevate to this level, buildings are typically evacuated and the costs associated with disruption of the building occupants, identification of the source of the problem, and eventual remediation can be significant. Understanding the primary causes of IAQ problems and how controllable factors--proper HVAC system design, allocation of adequate outdoor air, proper filtration, effective humidity control, and routine maintenance--can avert the problems may help all building owners, operators, and occupants to be more productive (Arens and Baughman 1996). This paper provides a comprehensive summary of IAQ research that has been conducted in various types of facilities. However, it focuses primarily on school facilities because, for numerous reasons that will become evident, they are far more susceptible to developing IAQ problems than most other types of facilities; and the occupants, children, are more significantly affected than adults (EPA 1998).

  17. Utilizing a logic model to identify clinical research problems: a lesson from philosophy of science

    Directory of Open Access Journals (Sweden)

    Collins CR

    2016-10-01

    Full Text Available Cynthia R Collins School of Nursing, College of Social Sciences, Loyola University, New Orleans, LA, USA Abstract: Communication and decision making in the health care workplace often involve finding solutions to ill-structured problems in uncertain, dynamic environments influenced by the competing interests of multiple stakeholders. In this environment, doctoral-prepared nurses who practice as administrators, policy makers, or advanced practice practitioners are often compelled to make important decisions based upon evaluating the merit of colleagues’ proposals against some desired organizational or population outcome. Of equal importance is the nurse leader’s own capacity to construct a compelling argument or proposal that will drive the organization forward to meet the evolving needs for quality health care. Where do we learn the skills necessary to foster this kind of critical thinking in our professional communications? The author suggests that one teaching–learning approach can be found through the thoughtful application of the work of British philosopher Steven Toulmin. Toulmin defined a model for both the analysis and derivation of logical arguments or proposals that can be readily learned and applied for use in health care systems. This model posits that a substantive argument or claim can be evaluated based on the assumptions it presumes (warrants and the strength of the evidence base (backing. Several of the social science professions have adapted Toulmin’s model to generate analysis and creative solutions to complex or emergent problems. The author proposes that an application of this model be included in the pedagogy of doctoral level Philosophy of Science or Nursing Theory courses. The Toulmin process often provides the doctoral student or novice researcher with their first real learning experience in defining the scope and inherent challenges of framing a clinical issue to be the focus of their scholarly translational

  18. A research agenda for helminth diseases of humans: the problem of helminthiases.

    Directory of Open Access Journals (Sweden)

    Sara Lustigman

    Full Text Available A disproportionate burden of helminthiases in human populations occurs in marginalised, low-income, and resource-constrained regions of the world, with over 1 billion people in developing areas of sub-Saharan Africa, Asia, and the Americas infected with one or more helminth species. The morbidity caused by such infections imposes a substantial burden of disease, contributing to a vicious circle of infection, poverty, decreased productivity, and inadequate socioeconomic development. Furthermore, helminth infection accentuates the morbidity of malaria and HIV/AIDS, and impairs vaccine efficacy. Polyparasitism is the norm in these populations, and infections tend to be persistent. Hence, there is a great need to reduce morbidity caused by helminth infections. However, major deficiencies exist in diagnostics and interventions, including vector control, drugs, and vaccines. Overcoming these deficiencies is hampered by major gaps in knowledge of helminth biology and transmission dynamics, platforms from which to help develop such tools. The Disease Reference Group on Helminths Infections (DRG4, established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR, was given the mandate to review helminthiases research and identify research priorities and gaps. In this review, we provide an overview of the forces driving the persistence of helminthiases as a public health problem despite the many control initiatives that have been put in place; identify the main obstacles that impede progress towards their control and elimination; and discuss recent advances, opportunities, and challenges for the understanding of the biology, epidemiology, and control of these infections. The helminth infections that will be discussed include: onchocerciasis, lymphatic filariasis, soil-transmitted helminthiases, schistosomiasis, food-borne trematodiases, and taeniasis/cysticercosis.

  19. The Development Of Learning Sets And Research Methodology Module Using Problem Based Learning For Accounting Education Students

    OpenAIRE

    Thomas, Partono; Nurkhin, Ahmad

    2016-01-01

    Improving the learning process is very important for every lecturer by implement innovative learning methods or media. The purpose of this study is to develop a research methodology learning instruction and module based of problem based learning for accounting education students. This research applied research and development design in the research methodology course in Economics Education (Accounting) Department, Faculty Of Economics, Semarang State University. Data analysis was used to test...

  20. Recent advances in Echinococcus genomics and stem cell research.

    Science.gov (United States)

    Koziol, U; Brehm, K

    2015-10-30

    Alveolar and cystic echinococcosis, caused by the metacestode larval stages of the tapeworms Echinococcus multilocularis and Echinococcus granulosus, respectively, are life-threatening diseases and very difficult to treat. The introduction of benzimidazole-based chemotherapy, which targets parasite β-tubulin, has significantly improved the life-span and prognosis of echinococcosis patients. However, benzimidazoles show only parasitostatic activity, are associated with serious adverse side effects and have to be administered for very long time periods, underlining the need for new drugs. Very recently, the nuclear genomes of E. multilocularis and E. granulosus have been characterised, revealing a plethora of data for gaining a deeper understanding of host-parasite interaction, parasite development and parasite evolution. Combined with extensive transcriptome analyses of Echinococcus life cycle stages these investigations also yielded novel clues for targeted drug design. Recent years also witnessed significant advancements in the molecular and cellular characterisation of the Echinococcus 'germinative cell' population, which forms a unique stem cell system that differs from stem cells of other organisms in the expression of several genes associated with the maintenance of pluripotency. As the only parasite cell type capable of undergoing mitosis, the germinative cells are central to all developmental transitions of Echinococcus within the host and to parasite expansion via asexual proliferation. In the present article, we will briefly introduce and discuss recent advances in Echinococcus genomics and stem cell research in the context of drug design and development. Interestingly, it turns out that benzimidazoles seem to have very limited effects on Echinococcus germinative cells, which could explain the high recurrence rates observed after chemotherapeutic treatment of echinococcosis patients. This clearly indicates that future efforts into the development of

  1. Concise review: carbon nanotechnology: perspectives in stem cell research.

    Science.gov (United States)

    Pryzhkova, Marina V

    2013-05-01

    Carbon nanotechnology has developed rapidly during the last decade, and carbon allotropes, especially graphene and carbon nanotubes, have already found a wide variety of applications in industry, high-tech fields, biomedicine, and basic science. Electroconductive nanomaterials have attracted great attention from tissue engineers in the design of remotely controlled cell-substrate interfaces. Carbon nanoconstructs are also under extensive investigation by clinical scientists as potential agents in anticancer therapies. Despite the recent progress in human pluripotent stem cell research, only a few attempts to use carbon nanotechnology in the stem cell field have been reported. However, acquired experience with and knowledge of carbon nanomaterials may be efficiently used in the development of future personalized medicine and in tissue engineering.

  2. Cost reduction has priority in solar cell research

    International Nuclear Information System (INIS)

    Van Zolingen, R.J.C.; Sinke, W.C.

    1993-01-01

    The main topic in the research and development of photovoltaic cells is cost reduction. Although new materials, improved techniques and increasing efficiency are promising aspects of the clean and sustainable option of a photovoltaic conversion of sunlight to produce electricity at a large scale, the high prices form an obstacle. Photovoltaic conversion is at least a factor three too expensive compared to the conventional power generation techniques by means of fossil fuels. Attention is paid to the theoretical maximum efficiency of photovoltaic conversion, the efficiencies realized sofar, the importance of thin film solar cells, the payback period of photovoltaic modules, the environmental impacts of using photovoltaic cells, and finally the costs. 2 figs., 1 ill., 2 tabs., 6 refs

  3. Single cell analysis contemporary research and clinical applications

    CERN Document Server

    Cossarizza, Andrea

    2017-01-01

    This book highlights the current state of the art in single cell analysis, an area that involves many fields of science – from clinical hematology, functional analysis and drug screening, to platelet and microparticle analysis, marine biology and fundamental cancer research. This book brings together an eclectic group of current applications, all of which have a significant impact on our current state of knowledge. The authors of these chapters are all pioneering researchers in the field of single cell analysis. The book will not only appeal to those readers more focused on clinical applications, but also those interested in highly technical aspects of the technologies. All of the technologies identified utilize unique applications of photon detection systems.

  4. Human cloning, stem cell research. An Islamic perspective.

    Science.gov (United States)

    Al-Aqeel, Aida I

    2009-12-01

    The rapidly changing technologies that involve human subjects raise complex ethical, legal, social, and religious issues. Recent advances in the field of cloning and stem cell research have introduced new hopes for the treatment of serious diseases. But this promise has raised many complex questions. This field causes debate and challenge, not only among scientists but also among ethicists, religious scholars, governments, and politicians. There is no consensus on the morality of human cloning, even within specific religious traditions. In countries in which religion has a strong influence on political decision making, the moral status of the human embryo is at the center of the debate. Because of the inevitable consequences of reproductive cloning, it is prohibited in Islam. However, stem cell research for therapeutic purposes is permissible with full consideration, and all possible precautions in the pre-ensoulment stages of early fetus development, if the source is legitimate.

  5. Cost Effective Polymer Solar Cells Research and Education

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Sam-Shajing [Norfolk State Univ, Norfolk, VA (United States)

    2015-10-13

    The technical or research objective of this project is to investigate and develop new polymers and polymer based optoelectronic devices for potentially cost effective (or cost competitive), durable, lightweight, flexible, and high efficiency solar energy conversion applications. The educational objective of this project includes training of future generation scientists, particularly young, under-represented minority scientists, working in the areas related to the emerging organic/polymer based solar energy technologies and related optoelectronic devices. Graduate and undergraduate students will be directly involved in scientific research addressing issues related to the development of polymer based solar cell technology.

  6. Maternal cell phone and cordless phone use during pregnancy and behaviour problems in 5-year-old children.

    Science.gov (United States)

    Guxens, Mònica; van Eijsden, Manon; Vermeulen, Roel; Loomans, Eva; Vrijkotte, Tanja G M; Komhout, Hans; van Strien, Rob T; Huss, Anke

    2013-05-01

    A previous study found an association between maternal cell phone use during pregnancy and maternal-reported child behaviour problems at age 7. Together with cell phones, cordless phones represent the main exposure source of radiofrequency-electromagnetic fields to the head. Therefore, we assessed the association between maternal cell phone and cordless phone use during pregnancy and teacher-reported and maternal-reported child behaviour problems at age 5. The study was embedded in the Amsterdam Born Children and their Development study, a population-based birth cohort study in Amsterdam, the Netherlands (2003-2004). Teachers and mothers reported child behaviour problems using the Strength and Difficulties Questionnaire at age 5. Maternal cell phone and cordless phone use during pregnancy was asked when children were 7 years old. A total of 2618 children were included. As compared to non-users, those exposed to prenatal cell phone use showed an increased but non-significant association of having teacher-reported overall behaviour problems, although without dose-response relationship with the number of calls (OR=2.12 (95% CI 0.95 to 4.74) for cell phone and cordless phone use with maternal-reported overall behaviour problems remained non-significant. Non-significant associations were found for the specific behaviour problem subscales. Our results do not suggest that maternal cell phone or cordless phone use during pregnancy increases the odds of behaviour problems in their children.

  7. Perspective role of stem cells application in neuropsychiatric research

    Czech Academy of Sciences Publication Activity Database

    Syková, Eva

    2003-01-01

    Roč. 13, č. 4 (2003), s. 148 ISSN 0924-977X. [Congress of the European College of Neuropsychopharmacology /16./. Prague, 20.09.2003-24.09.2003] R&D Projects: GA MŠk LN00A065; GA ČR GA304/03/1189 Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 111300004 Keywords : stem cells Subject RIV: FH - Neurology Impact factor: 2.842, year: 2003

  8. 2012 PLANT CELL WALLS GORDON RESEARCH CONFERENCE AND GORDON RESEARCH SEMINAR, AUGUST 4-10, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Jocelyn

    2012-08-10

    The sub-theme of this year’s meeting, ‘Cell Wall Research in a Post-Genome World’, will be a consideration of the dramatic technological changes that have occurred in the three years since the previous cell wall Gordon Conference in the area of DNA sequencing. New technologies are providing additional perspectives of plant cell wall biology across a rapidly growing number of species, highlighting a myriad of architectures, compositions, and functions in both "conventional" and specialized cell walls. This meeting will focus on addressing the knowledge gaps and technical challenges raised by such diversity, as well as our need to understand the underlying processes for critical applications such as crop improvement and bioenergy resource development.

  9. Ethical considerations in stem cell research on neurologic and orthopedic conditions.

    Science.gov (United States)

    Banja, John Dennis

    2015-04-01

    The range and gravity of ethical considerations in stem cell research are remarkable and, quite possibly, unprecedented. From the point of securing stem cells for implantation, through the translational and first-in-humans process, and then proceeding through clinical trials culminating in product or service line launch, the entire research trajectory is replete with risk, uncertainty, and problems overweighing foreseeable harms against hoped-for benefits. This article offers an overview of some of the most salient ethical challenges of stem cell research, including ones involving moral status, the intersection of research risks and informed consent processes, methodologic considerations in early phase 1 trials, the temptation to exaggerate the benefits of research discoveries, managing conflicts of interest, and the ethical obligation to conduct various monitoring practices throughout a trial, which could last years. The article will conclude with a glimpse into the future of these technologies wherein the need for ethical scrutiny will likely not diminish. Copyright © 2015. Published by Elsevier Inc.

  10. Present status of intermediate band solar cell research

    International Nuclear Information System (INIS)

    Cuadra, L.; Marti, A.; Luque, A.

    2004-01-01

    The intermediate band solar cell is a theoretical concept with the potential for exceeding the performance of conventional single-gap solar cells. This novel photovoltaic converter bases its superior theoretical efficiency over single-gap solar cells by enhancing its photogenerated current, via the two-step absorption of sub-band gap photons, without reducing its output voltage. This is achieved through a material with an electrically isolated and partially filled intermediate band located within a higher forbidden gap. This material is commonly named intermediate band material. This paper centres on summarising the present status of intermediate band solar cell research. A number of attempts, which aim to implement the intermediate band concept, are being followed: the direct engineering of the intermediate band material, its implementation by means of quantum dots and the highly porous material approach. Among other sub-band gap absorbing proposals, there is a renewed interest on the impurity photovoltaic effect, the quantum well solar cells and the particularly promising proposal for the use of up- and down-converters

  11. Multilineage Potential Research of Bovine Amniotic Fluid Mesenchymal Stem Cells

    Directory of Open Access Journals (Sweden)

    Yuhua Gao

    2014-02-01

    Full Text Available The use of amnion and amniotic fluid (AF are abundant sources of mesenchymal stem cells (MSCs that can be harvested at low cost and do not pose ethical conflicts. In human and veterinary research, stem cells derived from these tissues are promising candidates for disease treatment, specifically for their plasticity, their reduced immunogenicity, and high anti-inflammatory potential. This work aimed to obtain and characterize bovine amniotic fluid mesenchymal stem cells (AFMSC. The bovine AF from the amniotic cavity of pregnant gilts in the early stages of gestation (3- and 4-m-old bovine embryos was collected. AFMSCs exhibit a fibroblastic-like morphology only starting from the fourth passage, being heterogeneous during the primary culture. Immunofluorescence results showed that AFMSCs were positive for β-integrin, CD44, CD73 and CD166, but negative for CD34, CD45. Meanwhile, AFMSCs expressed ES cell markers, such as Oct4, and when appropriately induced, are capable of differentiating into ectodermal and mesodermal lineages. This study reinforces the emerging importance of these cells as ideal tools in veterinary medicine; future studies aimed at a deeper evaluation of their immunological properties will allow a better understanding of their role in cellular therapy.

  12. [The health problems which can brougth by 3G cell phones to our country].

    Science.gov (United States)

    Enöz, Murat

    2009-01-01

    At present, we are being exposed to electromagnetic pollution which is steadily increasing parallel to the technological advancements and which is invisible and unnoticeable in the short run. Electromagnetic waves which were previously used for therapeutic reasons have recently been uncontrollably used in daily life. By widespread use of 3rd generation (3G) cellular phones, the electromagnetic pollution has multiplied and brought us a huge amount of health dangers in our country. In this article, electromagnetic pollution, which is a comprehensive topic, and problems related with this kind of pollution which is rapidly increasing due to recent wide use of 3G cell phones are summarized in the light of the literature.

  13. Parent reported sleep problems in preschool children with sickle cell anemia and controls in East London.

    Science.gov (United States)

    Downes, Michelle; de Haan, Michelle; Kirkham, Fenella J; Telfer, Paul T

    2017-06-01

    Snoring and poor sleep may affect cognition, particularly in young children with chronic conditions. Parents of London preschoolers with sickle cell anemia (SCA; n = 22), matched controls (n = 24), and unselected typically developing (n = 142) preschoolers completed sleep questionnaires. Preschoolers with SCA had significantly more sleep problems when compared to matched controls and the larger population. Snoring occurred at least one to two nights a week for 79% of the SCA group. This is compared with 25% of matched controls and 33% of larger population. Randomized controlled trials to improve sleep in young children with SCA already at-risk for cognitive dysfunction should be considered. © 2016 Wiley Periodicals, Inc.

  14. An adaptive simplex cut-cell method for high-order discontinuous Galerkin discretizations of elliptic interface problems and conjugate heat transfer problems

    Science.gov (United States)

    Sun, Huafei; Darmofal, David L.

    2014-12-01

    In this paper we propose a new high-order solution framework for interface problems on non-interface-conforming meshes. The framework consists of a discontinuous Galerkin (DG) discretization, a simplex cut-cell technique, and an output-based adaptive scheme. We first present a DG discretization with a dual-consistent output evaluation for elliptic interface problems on interface-conforming meshes, and then extend the method to handle multi-physics interface problems, in particular conjugate heat transfer (CHT) problems. The method is then applied to non-interface-conforming meshes using a cut-cell technique, where the interface definition is completely separate from the mesh generation process. No assumption is made on the interface shape (other than Lipschitz continuity). We then equip our strategy with an output-based adaptive scheme for an accurate output prediction. Through numerical examples, we demonstrate high-order convergence for elliptic interface problems and CHT problems with both smooth and non-smooth interface shapes.

  15. Effects of Singapore's Model Method on Elementary Student Problem Solving Performance: Single Subject Research

    Science.gov (United States)

    Mahoney, Kevin

    2012-01-01

    This research investigation examined the effects of Singapore's Model Method, also known as "model drawing" or "bar modeling" on the word problem-solving performance of American third and fourth grade students. Employing a single-case design, a researcher-designed teaching intervention was delivered to a child in third…

  16. Thoughts and Practice on Some Problems about Research and Application of Two-Line Hybrid Rice

    Directory of Open Access Journals (Sweden)

    Li-yun CHEN

    2011-06-01

    Full Text Available The main problems about research and application of two-line hybrid rice were reviewed, including the confusing nomenclature and male sterile lines classification, the unclear characteristics of photoperiod and temperature responses and the unsuitable site selection for male sterile line and hybrid rice seed production. In order to efficiently and accurately use dual-purpose genic male sterile lines, four types, including PTGMS (photo-thermo-sensitive genic male sterile rice, TGMS (thermo-sensitive genic male sterile rice, reverse PTGMS and reverse TGMS, were proposed. A new idea for explaining the mechanism of sterility in dual-purpose hybrid rice was proposed. The transition from sterile to fertile was involved in the cooperative regulation of major-effect sterile genes and photoperiod and/or temperature sensitive ones. The minor-effect genes with accumulative effect on sterility were important factors that affected the critical temperature of sterility transfer. In order to make better use of dual-purpose lines, the characterization of responses to photoperiod and temperature of PTGMS should be made and the identification method for the characterization of photoperiod and temperature responses of PTGMS should also be put forward. The optimal ecological site for seed production could be determined according to the historical climate data and the requirements for the meteorological conditions during the different periods of seed production.

  17. Private Data -- The Real Story: A Huge Problem with Education Research

    Directory of Open Access Journals (Sweden)

    R. James Milgram

    2012-12-01

    Full Text Available A very influential paper on improving math outcomes was published in 2008. The authors refused to divulge their data claiming that agreements with the schools and Family Educational Rights and Privacy Act rules (FERPA prevented it.● It turns out that this is not true.● The claimed legal foundations do not say what these authors said they do, this this is a widespread misconception among education researchers.When we found the identities of the schools by other means, serious problems with the conclusions of the article were quickly revealed.● The 2008 paper was far from unique in this respect.● There are many papers that have had enormous influences on K-12 mathematics curricula, and could not be independently verified because the authors refused to reveal their data.In this article we describe how we were able to find the real data for the 2008 paper, and point out the legal constraints that should make it very difficult for authors of such papers to withhold their data in the future.

  18. PS3 CELL Development for Scientific Computation and Research

    Science.gov (United States)

    Christiansen, M.; Sevre, E.; Wang, S. M.; Yuen, D. A.; Liu, S.; Lyness, M. D.; Broten, M.

    2007-12-01

    The Cell processor is one of the most powerful processors on the market, and researchers in the earth sciences may find its parallel architecture to be very useful. A cell processor, with 7 cores, can easily be obtained for experimentation by purchasing a PlayStation 3 (PS3) and installing linux and the IBM SDK. Each core of the PS3 is capable of 25 GFLOPS giving a potential limit of 150 GFLOPS when using all 6 SPUs (synergistic processing units) by using vectorized algorithms. We have used the Cell's computational power to create a program which takes simulated tsunami datasets, parses them, and returns a colorized height field image using ray casting techniques. As expected, the time required to create an image is inversely proportional to the number of SPUs used. We believe that this trend will continue when multiple PS3s are chained using OpenMP functionality and are in the process of researching this. By using the Cell to visualize tsunami data, we have found that its greatest feature is its power. This fact entwines well with the needs of the scientific community where the limiting factor is time. Any algorithm, such as the heat equation, that can be subdivided into multiple parts can take advantage of the PS3 Cell's ability to split the computations across the 6 SPUs reducing required run time by one sixth. Further vectorization of the code can allow for 4 simultanious floating point operations by using the SIMD (single instruction multiple data) capabilities of the SPU increasing efficiency 24 times.

  19. Discarded human fetal tissue and cell cultures for transplantation research

    International Nuclear Information System (INIS)

    Hay, R.J.; Phillips, T.; Thompson, A.; Vilner, L.; Cleland, M.; Tchaw-ren Chen; Zabrenetzky, V.

    1999-01-01

    A feasibility study has been performed to explore the utility of various tissues from discarded human abortuses for transplantation and related research. Specifically, aborted fetuses plus parental blood samples and all relevant clinical data were obtained through a local hospital complex. Whenever possible, pancreas, skin and skeletal muscle, heart, liver, kidney, cartilage and lung tissues were removed, dissociated and subfractionated for cryopreservation, characterization and cultivation trials in vitro. Existing protocols for these manipulations were compared and improved upon as required. Clonal culture, cell aggregate maintenance techniques and use of feeder cell populations have been utilized where appropriate to develop quantitative comparative data. Histological and biochemical assays were applied both to evaluate separation/cultivation methods and to identify optimal culture conditions for maintaining functional cells. Immunochemical and molecular biological procedures were applied to study expression of Major Histocompatibility Vomplex (MHC) class 1 and 11 molecules on cell lines derived. Tissue and cell culture populations were examined for infections with bacteria, ftingi, mycoplasma, HIV, CMV, hepatitis B and other viruses. Only 1% of the abortuses tested were virally infected. Cytogenetic analyses confin-ned the normal diploid status in the vast majority (>98%) of lines tested. A total of over 250 abortuses have been obtained and processed. Only 25 were found to be contaminated with bacteria or fungi and unsuitable for further cultivation trials. A total of over 200 cell populations were isolated, characterized and cryopreserved for further study. Included were kidney, lung, liver and epidermal epithelia: cartilage-derived cells from the spine and epiphyses plus myogenic myoblasts. Selected lines have been immortalized using HPV I 6E6/E7 sequences. Epithelia from the liver and pancreas and cardiac myocytes were the most problematic in that initial

  20. RESEARCH ON PROBLEMS WITH PROJECTS AND PARTNERSHIPS THAT PUBLIC INSTITUTIONS IN THE CENTRE REGION FACED IN ACCESSING EUROPEAN FUNDS

    Directory of Open Access Journals (Sweden)

    DUMITRASCU DANUT

    2012-12-01

    Full Text Available European project management is the main filed of the article. Assuming a connection between the degree of absorption of European funds and the degree of maturity of the Romanian society in terms of project management, the article seeks to identify the negative factors on accessing and carrying out European projects. The identified problem is a low degree of absorption of European funds in Romania, and the main objective of the research is to identify the problems faced by the public institutions in the Centre Region in accessing European funds and also the causes that led to the low absorption of European funds. This article’s research is based on a preliminary analysis performed by the authors on the rate of accessing of European funds published in the article called “The current state of European funds absorption through funding programmes – measure of the Romanian performances in the project management practice”. The conclusion of this article was a low rate of absorption of European funds in Romania, a fact that reveals a poor practice of the theory on project management. This article identifies part of the causes of this situation by identifying a part of the problems that stood in the way of beneficiaries of European funds The qualitative and quantitative research methods are used in combination in the research. The investigation has however a highly quantitative character, the purpose of the qualitative research being to provide the prerequisites for achieving the quantitative research. The interview-based qualitative research enabled the researcher to get acquainted with the subjects’ problems related to the theme of investigation, the causes that have generated these problems. This preliminary investigation to the questionnaire-based research aims to provide information that would help the researcher prepare the questionnaire, so that the questions allow getting the most comprehensive information to

  1. Countermeasure Research on Problems Impeding Farmers’ Successful Entrepreneurship in Minority Areas

    OpenAIRE

    Feng, Xiao-jin; Xu, Cong-wei

    2011-01-01

    By investigating the problem of farmers’ entrepreneurship in Gongcheng Yaozu Autonomous County, lying in Guilin, Guangxi, the thesis expounds the existing problems impacting farmers’ successful entrepreneurship in minority areas as follows: firstly, the musty idea of local cadre is obstacle to farmers’ successful entrepreneurship; secondly, the problems of scattered farmers’ entrepreneurship resources, waste and shortage of resources impact good effect of entrepreneurship; thirdly, fa...

  2. Stem cell research and therapies in Argentina: the legal and regulatory approach.

    Science.gov (United States)

    de Arzuaga, Fabiana C

    2013-12-01

    Argentina has a significant number of researchers in public and private institutions conducting research in regenerative medicine and stem cells. There is not specific legislation in this area; however, the National Ministry of Health has issued regulations under the scope of the Transplant Act and the Medicines Act. Alongside the groups doing research, it is possible to find professionals offering experimental stem cell therapies to patients. These professionals take refuge in the term "medical practice" and sell experimental treatment to patients with no guarantee of safety and security given that they were not tested in clinical research. These practices offered to patients in a scheme, apparently legal, are generating an important number of judicial actions requesting the payment of said treatments. The decisions of the courts ordering payment in most cases are generating a transfer of funds from patients, social welfare systems, and the state to medical centers offering stem cell experimental therapies. This article describes the current regulations as well as the course of action to solve the emerging problems of these new technologies at legislative level.

  3. Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells

    Directory of Open Access Journals (Sweden)

    Karen Bieback

    2010-01-01

    Full Text Available It sounds simple to obtain sufficient numbers of cells derived from fetal or adult human tissues, isolate and/or expand the stem cells, and then transplant an appropriate number of these cells into the patient at the correct location. However, translating basic research into routine therapies is a complex multistep process which necessitates product regulation. The challenge relates to managing the expected therapeutic benefits with the potential risks and to balance the fast move to clinical trials with time-consuming cautious risk assessment. This paper will focus on the definition of mesenchymal stromal cells (MSCs, and challenges and achievements in the manufacturing process enabling their use in clinical studies. It will allude to different cellular sources, special capacities of MSCs, but also to current regulations, with a special focus on accessory material of human or animal origin, like media supplements. As cellular integrity and purity, formulation and lot release testing of the final product, validation of all procedures, and quality assurance are of utmost necessity, these topics will be addressed.

  4. Modifying a Research-Based Problem-Solving Intervention to Improve the Problem-Solving Performance of Fifth and Sixth Graders With and Without Learning Disabilities.

    Science.gov (United States)

    Krawec, Jennifer; Huang, Jia

    The purpose of the present study was to test the efficacy of a modified cognitive strategy instructional intervention originally developed to improve the mathematical problem solving of middle and high school students with learning disabilities (LD). Fifth and sixth grade general education mathematics teachers and their students of varying ability (i.e., average-achieving [AA] students, low-achieving [LA] students, and students with LD) participated in the research study. Several features of the intervention were modified, including (a) explicitness of instruction, (b) emphasis on meta-cognition, (c) focus on problem-solving prerequisites, (d) extended duration of initial intervention, and (e) addition of visual supports. General education math teachers taught all instructional sessions to their inclusive classrooms. Curriculum-based measures (CBMs) of math problem solving were administered five times over the course of the year. A multilevel model (repeated measures nested within students and students nested within schools) was used to analyze student progress on CBMs. Though CBM scores in the intervention group were initially lower than that of the comparison group, intervention students improved significantly more in the first phase, with no differences in the second phase. Implications for instruction are discussed as well as directions for future research.

  5. Solving the influence maximization problem reveals regulatory organization of the yeast cell cycle.

    Directory of Open Access Journals (Sweden)

    David L Gibbs

    2017-06-01

    Full Text Available The Influence Maximization Problem (IMP aims to discover the set of nodes with the greatest influence on network dynamics. The problem has previously been applied in epidemiology and social network analysis. Here, we demonstrate the application to cell cycle regulatory network analysis for Saccharomyces cerevisiae. Fundamentally, gene regulation is linked to the flow of information. Therefore, our implementation of the IMP was framed as an information theoretic problem using network diffusion. Utilizing more than 26,000 regulatory edges from YeastMine, gene expression dynamics were encoded as edge weights using time lagged transfer entropy, a method for quantifying information transfer between variables. By picking a set of source nodes, a diffusion process covers a portion of the network. The size of the network cover relates to the influence of the source nodes. The set of nodes that maximizes influence is the solution to the IMP. By solving the IMP over different numbers of source nodes, an influence ranking on genes was produced. The influence ranking was compared to other metrics of network centrality. Although the top genes from each centrality ranking contained well-known cell cycle regulators, there was little agreement and no clear winner. However, it was found that influential genes tend to directly regulate or sit upstream of genes ranked by other centrality measures. The influential nodes act as critical sources of information flow, potentially having a large impact on the state of the network. Biological events that affect influential nodes and thereby affect information flow could have a strong effect on network dynamics, potentially leading to disease. Code and data can be found at: https://github.com/gibbsdavidl/miergolf.

  6. Solving the influence maximization problem reveals regulatory organization of the yeast cell cycle

    Science.gov (United States)

    Shmulevich, Ilya

    2017-01-01

    The Influence Maximization Problem (IMP) aims to discover the set of nodes with the greatest influence on network dynamics. The problem has previously been applied in epidemiology and social network analysis. Here, we demonstrate the application to cell cycle regulatory network analysis for Saccharomyces cerevisiae. Fundamentally, gene regulation is linked to the flow of information. Therefore, our implementation of the IMP was framed as an information theoretic problem using network diffusion. Utilizing more than 26,000 regulatory edges from YeastMine, gene expression dynamics were encoded as edge weights using time lagged transfer entropy, a method for quantifying information transfer between variables. By picking a set of source nodes, a diffusion process covers a portion of the network. The size of the network cover relates to the influence of the source nodes. The set of nodes that maximizes influence is the solution to the IMP. By solving the IMP over different numbers of source nodes, an influence ranking on genes was produced. The influence ranking was compared to other metrics of network centrality. Although the top genes from each centrality ranking contained well-known cell cycle regulators, there was little agreement and no clear winner. However, it was found that influential genes tend to directly regulate or sit upstream of genes ranked by other centrality measures. The influential nodes act as critical sources of information flow, potentially having a large impact on the state of the network. Biological events that affect influential nodes and thereby affect information flow could have a strong effect on network dynamics, potentially leading to disease. Code and data can be found at: https://github.com/gibbsdavidl/miergolf. PMID:28628618

  7. Solving the influence maximization problem reveals regulatory organization of the yeast cell cycle.

    Science.gov (United States)

    Gibbs, David L; Shmulevich, Ilya

    2017-06-01

    The Influence Maximization Problem (IMP) aims to discover the set of nodes with the greatest influence on network dynamics. The problem has previously been applied in epidemiology and social network analysis. Here, we demonstrate the application to cell cycle regulatory network analysis for Saccharomyces cerevisiae. Fundamentally, gene regulation is linked to the flow of information. Therefore, our implementation of the IMP was framed as an information theoretic problem using network diffusion. Utilizing more than 26,000 regulatory edges from YeastMine, gene expression dynamics were encoded as edge weights using time lagged transfer entropy, a method for quantifying information transfer between variables. By picking a set of source nodes, a diffusion process covers a portion of the network. The size of the network cover relates to the influence of the source nodes. The set of nodes that maximizes influence is the solution to the IMP. By solving the IMP over different numbers of source nodes, an influence ranking on genes was produced. The influence ranking was compared to other metrics of network centrality. Although the top genes from each centrality ranking contained well-known cell cycle regulators, there was little agreement and no clear winner. However, it was found that influential genes tend to directly regulate or sit upstream of genes ranked by other centrality measures. The influential nodes act as critical sources of information flow, potentially having a large impact on the state of the network. Biological events that affect influential nodes and thereby affect information flow could have a strong effect on network dynamics, potentially leading to disease. Code and data can be found at: https://github.com/gibbsdavidl/miergolf.

  8. One cell, one love: a journal for microbial research

    Directory of Open Access Journals (Sweden)

    Didac Carmona-Gutierrez

    2014-01-01

    Full Text Available With their broad utility for biotechnology, their continuous menace as infectious pathogens, and as an integral part of our bodies (intestinal flora, unicellular organisms remain in the focus of global research. This interest has been further stimulated by the challenge to counteract the emergence of multi-resistant microbes, as well as by the recent advances in establishing unicellular organisms as valid models for human diseases. It is our great pleasure to launch the inaugural issue of Microbial Cell (MIC, an international, open-access, peer-reviewed journal dedicated to microbial research. MIC is committed to the publication of articles that deal with the characterization of unicellular organisms (or multicellular microorganisms in their response to internal and external stimuli and/or in the context of human health and disease. Thus, MIC covers heterogeneous topics in diverse areas ranging from microbial and general cell biology to molecular signaling, disease modeling and pathogen targeting. MIC’s Editorial Board counts with world-class leaders in a wide variety of fields, including microbiology, aging, evolution, biotechnology, ecology, biochemistry, infection biology, and human pathophysiology. We are convinced that MIC will appeal to readers from a broad scientific and medical background, including basic researchers, microbiologists, clinicians, educators and – we hope – policy makers as well as to any interested individual.

  9. Electrical research on solar cells and photovoltaic materials

    Science.gov (United States)

    Orehotsky, J.

    1985-01-01

    A systematic study of the properties of various polymer pottant materials and of the electrochemical corrosion mechanisms in solar cell materials is required for advancing the technology of terrestrial photovoltaic modules. The items of specific concern in this sponsored research activity involve: (1) kinetics of plasticizer loss in PVB, (2) kinetics of water absorption and desorption in PVB, (3) kinetics of water absorption and desorption in EVA, (4) the electrical properties at PVB as a function of temperature and humidity, (5) the electrical properties of EVA as a function of temperature and humidity, (6) solar cell corrosion characteristics, (7) water absorption effects in PVB and EVA, and (8) ion implantation and radiation effects in PVB and EVA.

  10. Administrative Problems in the Single-Track Year-Round High Schools: Research Findings and Guidelines.

    Science.gov (United States)

    Holt, Laura L.; Karr-Kidwell, PJ

    An analysis of the problems pertaining to the adoption of a year-round calendar for high schools, along with the advantages of year-round education (YRE), are examined. It provides a literary review (including historical contexts), types of calendars, benefits, administrative problems, and societal benefits. For the study, 28 schools responded to…

  11. Genome editing in pluripotent stem cells: research and therapeutic applications

    Energy Technology Data Exchange (ETDEWEB)

    Deleidi, Michela, E-mail: michela.deleidi@dzne.de [German Center for Neurodegenerative Diseases (DZNE) Tübingen within the Helmholtz Association, Tübingen (Germany); Hertie Institute for Clinical Brain Research, University of Tübingen (Germany); Yu, Cong [Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, New York (United States)

    2016-05-06

    Recent progress in human pluripotent stem cell (hPSC) and genome editing technologies has opened up new avenues for the investigation of human biology in health and disease as well as the development of therapeutic applications. Gene editing approaches with programmable nucleases have been successfully established in hPSCs and applied to study gene function, develop novel animal models and perform genetic and chemical screens. Several studies now show the successful editing of disease-linked alleles in somatic and patient-derived induced pluripotent stem cells (iPSCs) as well as in animal models. Importantly, initial clinical trials have shown the safety of programmable nucleases for ex vivo somatic gene therapy. In this context, the unlimited proliferation potential and the pluripotent properties of iPSCs may offer advantages for gene targeting approaches. However, many technical and safety issues still need to be addressed before genome-edited iPSCs are translated into the clinical setting. Here, we provide an overview of the available genome editing systems and discuss opportunities and perspectives for their application in basic research and clinical practice, with a particular focus on hPSC based research and gene therapy approaches. Finally, we discuss recent research on human germline genome editing and its social and ethical implications. - Highlights: • Programmable nucleases have proven efficient and specific for genome editing in human pluripotent stem cells (hPSCs). • Genome edited hPSCs can be employed to study gene function in health and disease as well as drug and chemical screens. • Genome edited hPSCs hold great promise for ex vivo gene therapy approaches. • Technical and safety issues should be first addressed to advance the clinical use of gene-edited hPSCs.

  12. Genome editing in pluripotent stem cells: research and therapeutic applications

    International Nuclear Information System (INIS)

    Deleidi, Michela; Yu, Cong

    2016-01-01

    Recent progress in human pluripotent stem cell (hPSC) and genome editing technologies has opened up new avenues for the investigation of human biology in health and disease as well as the development of therapeutic applications. Gene editing approaches with programmable nucleases have been successfully established in hPSCs and applied to study gene function, develop novel animal models and perform genetic and chemical screens. Several studies now show the successful editing of disease-linked alleles in somatic and patient-derived induced pluripotent stem cells (iPSCs) as well as in animal models. Importantly, initial clinical trials have shown the safety of programmable nucleases for ex vivo somatic gene therapy. In this context, the unlimited proliferation potential and the pluripotent properties of iPSCs may offer advantages for gene targeting approaches. However, many technical and safety issues still need to be addressed before genome-edited iPSCs are translated into the clinical setting. Here, we provide an overview of the available genome editing systems and discuss opportunities and perspectives for their application in basic research and clinical practice, with a particular focus on hPSC based research and gene therapy approaches. Finally, we discuss recent research on human germline genome editing and its social and ethical implications. - Highlights: • Programmable nucleases have proven efficient and specific for genome editing in human pluripotent stem cells (hPSCs). • Genome edited hPSCs can be employed to study gene function in health and disease as well as drug and chemical screens. • Genome edited hPSCs hold great promise for ex vivo gene therapy approaches. • Technical and safety issues should be first addressed to advance the clinical use of gene-edited hPSCs.

  13. Each cell counts: Hematopoiesis and immunity research in the era of single cell genomics.

    Science.gov (United States)

    Jaitin, Diego Adhemar; Keren-Shaul, Hadas; Elefant, Naama; Amit, Ido

    2015-02-01

    Hematopoiesis and immunity are mediated through complex interactions between multiple cell types and states. This complexity is currently addressed following a reductionist approach of characterizing cell types by a small number of cell surface molecular features and gross functions. While the introduction of global transcriptional profiling technologies enabled a more comprehensive view, heterogeneity within sampled populations remained unaddressed, obscuring the true picture of hematopoiesis and immune system function. A critical mass of technological advances in molecular biology and genomics has enabled genome-wide measurements of single cells - the fundamental unit of immunity. These new advances are expected to boost detection of less frequent cell types and fuzzy intermediate cell states, greatly expanding the resolution of current available classifications. This new era of single-cell genomics in immunology research holds great promise for further understanding of the mechanisms and circuits regulating hematopoiesis and immunity in both health and disease. In the near future, the accuracy of single-cell genomics will ultimately enable precise diagnostics and treatment of multiple hematopoietic and immune related diseases. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Quantitative and qualitative approaches in educational researchproblems and examples of controlled understanding through interpretive methods

    Science.gov (United States)

    Neumann, Karl

    1987-06-01

    In the methodological discussion of recent years it has become apparent that many research problems, including problems relating to the theory of educational science, cannot be solved by using quantitative methods. The multifaceted aspects of human behaviour and all its environment-bound subtle nuances, especially the process of education or the development of identity, cannot fully be taken into account within a rigid neopositivist approach. In employing the paradigm of symbolic interactionism as a suitable model for the analysis of processes of education and formation, the research has generally to start out from complex reciprocal social interactions instead of unambigious connections of causes. In analysing several particular methodological problems, the article demonstrates some weaknesses of quantitative approaches and then shows the advantages in and the necessity for using qualitative research tools.

  15. Efforts to develop a cultured sponge cell line: revisiting an intractable problem.

    Science.gov (United States)

    Grasela, James J; Pomponi, Shirley A; Rinkevich, Buki; Grima, Jennifer

    2012-01-01

    Residents of the marine environment, sponges (Porifera) have the ability to produce organic compounds known as secondary metabolites, which are not directly involved in the normal growth, development, or reproduction of an organism. Because of their sessile nature, the production of these bioactive compounds has been interpreted as a functional adaptation to serve in an important survival role as a means to counter various environmental stress factors such as predation, overgrowth by fouling organisms, or competition for limited space. Regardless of the reasons for this adaptation, a variety of isolated compounds have already proven to demonstrate remarkable anticancer, fungicidal, and antibiotic properties. A major obstacle to the isolation and production of novel compounds from sponges is the lack of a large, reliable source of sponge material. Sponge collection from the sea would be environmentally detrimental to the already stressed and sparse sponge populations. Sponge production in an aquaculture setting might appear to be an ideal alternative but would also be cost-ineffective and sponge growth is extremely slow. A third approach involves the development of a sponge cell culture system capable of producing the necessary cell numbers to harvest for research purposes as well as for the eventual commercial-scale production of promising bioactive compounds. Unfortunately, little progress has been made in this direction other than the establishment of temporary cultures containing aggregates and fragments of cells. One impediment toward successful sponge cell culture might be ascribed to a lack of published knowledge of failed methodologies, and thus, time and effort is wasted on continued reinvention of the same methods and procedures. Consequently, we have undertaken here to chart some of our unsuccessful research efforts, our methodology, and results to provide the sponge research community with knowledge to assist them to better avoid taking the same failed

  16. Some manufacture and installation problems in experimental assemblies for fusion research

    International Nuclear Information System (INIS)

    Partridge, J.E.; Rappe, G.; Hoare, F.; McDonald, J.

    1976-01-01

    Many of the manufacturing problems encountered when developing specialised items of fusion apparatus are only solved after much experimentation and a good deal of trial and error. After the experiment is built such problems may be forgotten and are often not recorded so that subsequent workers in the same field may start with no past experience on which to build. The paper therefore highlights some of the manufacturing problems which have been solved during the construction of some of the experimental apparatus at Culham

  17. Maternal cell phone and cordless phone use during pregnancy and behaviour problems in 5-year-old children

    NARCIS (Netherlands)

    Guxens, Mònica; van Eijsden, Manon; Vermeulen, Roel; Loomans, Eva; Vrijkotte, Tanja G. M.; Komhout, Hans; van Strien, Rob T.; Huss, Anke

    2013-01-01

    A previous study found an association between maternal cell phone use during pregnancy and maternal-reported child behaviour problems at age 7. Together with cell phones, cordless phones represent the main exposure source of radiofrequency-electromagnetic fields to the head. Therefore, we assessed

  18. Maternal cell phone and cordless phone use during pregnancy and behaviour problems in 5-year-old children

    NARCIS (Netherlands)

    Guxens, M.; van Eijsden, M.; Vermeulen, R.; Loomans, E.M.; Vrijkotte, T.G.M.; Komhout, H.; van Strien, H.; Huss, A.

    2013-01-01

    Background A previous study found an association between maternal cell phone use during pregnancy and maternal-reported child behaviour problems at age 7. Together with cell phones, cordless phones represent the main exposure source of radiofrequency-electromagnetic fields to the head. Therefore, we

  19. Maternal cell phone and cordless phone use during pregnancy and behaviour problems in 5-year-old children

    NARCIS (Netherlands)

    Guxens, M.; van Eijsden, M.; Vermeulen, R.; Loomans, E.; Vrijkotte, T.G.M.; Komhout, H.; van Strien, R.T.; Huss, A.

    2013-01-01

    Background: A previous study found an association between maternal cell phone use during pregnancy and maternal-reported child behaviour problems at age 7. Together with cell phones, cordless phones represent the main exposure source of radiofrequency-electromagnetic fields to the head. Therefore,

  20. Assessment of some of the problems in the USA of superconducting magnets for fusion research

    International Nuclear Information System (INIS)

    Cornish, D.N.

    1981-01-01

    This paper discusses some of the general difficulties and problems encountered during the development of the technology of superconductors and superconducting magnets for fusion and expresses some personal concerns

  1. The problem of causality in corporate governance research: The case of governance indexes and firm valuation

    Directory of Open Access Journals (Sweden)

    Jimmy A. Saravia

    2017-09-01

    Full Text Available In recent years the problem of the determination of causality has become an increasingly important question in the field of corporate governance. This paper reviews contemporary literature on the topic of causality, specifically it examines the literature that investigates the causal relationship between corporate governance indexes and firm valuation and finds that the current approach is to attempt to determine causality empirically and that the problem remains unresolved. After explaining the reasons why it is not possible to attempt to determine causality using real world data without falling prey to a logical fallacy, this paper discusses a traditional approach used in science to deal with the problem. In particular, the paper argues that the appropriate approach for the problem is to build theories, with causality featuring as a part of those theories, and then to test those theories both for logical and empirical consistency.

  2. Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research

    Directory of Open Access Journals (Sweden)

    Satoru Morikawa

    2016-01-01

    Full Text Available Craniofacial skeletal tissues are composed of tooth and bone, together with nerves and blood vessels. This composite material is mainly derived from neural crest cells (NCCs. The neural crest is transient embryonic tissue present during neural tube formation whose cells have high potential for migration and differentiation. Thus, NCCs are promising candidates for craniofacial tissue regeneration; however, the clinical application of NCCs is hindered by their limited accessibility. In contrast, mesenchymal stem cells (MSCs are easily accessible in adults, have similar potential for self-renewal, and can differentiate into skeletal tissues, including bones and cartilage. Therefore, MSCs may represent good sources of stem cells for clinical use. MSCs are classically identified under adherent culture conditions, leading to contamination with other cell lineages. Previous studies have identified mouse- and human-specific MSC subsets using cell surface markers. Additionally, some studies have shown that a subset of MSCs is closely related to neural crest derivatives and endothelial cells. These MSCs may be promising candidates for regeneration of craniofacial tissues from the perspective of developmental fate. Here, we review the fundamental biology of MSCs in craniofacial research.

  3. A Meshfree Cell-based Smoothed Point Interpolation Method for Solid Mechanics Problems

    International Nuclear Information System (INIS)

    Zhang Guiyong; Liu Guirong

    2010-01-01

    In the framework of a weakened weak (W 2 ) formulation using a generalized gradient smoothing operation, this paper introduces a novel meshfree cell-based smoothed point interpolation method (CS-PIM) for solid mechanics problems. The W 2 formulation seeks solutions from a normed G space which includes both continuous and discontinuous functions and allows the use of much more types of methods to create shape functions for numerical methods. When PIM shape functions are used, the functions constructed are in general not continuous over the entire problem domain and hence are not compatible. Such an interpolation is not in a traditional H 1 space, but in a G 1 space. By introducing the generalized gradient smoothing operation properly, the requirement on function is now further weakened upon the already weakened requirement for functions in a H 1 space and G 1 space can be viewed as a space of functions with weakened weak (W 2 ) requirement on continuity. The cell-based smoothed point interpolation method (CS-PIM) is formulated based on the W 2 formulation, in which displacement field is approximated using the PIM shape functions, which possess the Kronecker delta property facilitating the enforcement of essential boundary conditions [3]. The gradient (strain) field is constructed by the generalized gradient smoothing operation within the cell-based smoothing domains, which are exactly the triangular background cells. A W 2 formulation of generalized smoothed Galerkin (GS-Galerkin) weak form is used to derive the discretized system equations. It was found that the CS-PIM possesses the following attractive properties: (1) It is very easy to implement and works well with the simplest linear triangular mesh without introducing additional degrees of freedom; (2) it is at least linearly conforming; (3) this method is temporally stable and works well for dynamic analysis; (4) it possesses a close-to-exact stiffness, which is much softer than the overly-stiff FEM model and

  4. Stem Cell, Regenerative Medicine and Cancer | Center for Cancer Research

    Science.gov (United States)

    Of the estimated trillion cells that build up our bodies, only a little number can self-renew and give rise to many different cell types. These unspecialized cells are called stem cells. Stem cell division and differentiation is fundamental to the development of the mature organism. Stem cells have recently attracted significant attention largely due to their potential medical

  5. Community problem-solving framed as a distributed information use environment: bridging research and practice

    Directory of Open Access Journals (Sweden)

    Joan C. Durrance

    2006-01-01

    Full Text Available Introduction. This article results from a qualitative study of 1 information behavior in community problem-solving framed as a distributed information use environment and 2 approaches used by a best-practice library to anticipate information needs associated with community problem solving. Method. Several approaches to data collection were used - focus groups, interviews, observation of community and library meetings, and analysis of supporting documents. We focused first on the information behaviour of community groups. Finding that the library supported these activities we sought to understand its approach. Analysis. Data were coded thematically for both information behaviour concepts and themes germane to problem-solving activity. A grounded theory approach was taken to capture aspects of the library staff's practice. Themes evolved from the data; supporting documentation - reports, articles and library communication - was also coded. Results. The study showed 1 how information use environment components (people, setting, problems, problem resolutions combine in this distributed information use environment to determine specific information needs and uses; and 2 how the library contributed to the viability of this distributed information use environment. Conclusion. Community problem solving, here explicated as a distributed IUE, is likely to be seen in multiple communities. The library model presented demonstrates that by reshaping its information practice within the framework of an information use environment, a library can anticipate community information needs as they are generated and where they are most relevant.

  6. Parents of children with chronic health problems: programs of nursing research and their relationship to developmental science.

    Science.gov (United States)

    Miles, Margaret Shandor

    2003-01-01

    This review identified nurse researchers and research teams that have current programs of research focused on parents and parenting of children with chronic health problems. Researchers were included if they had at least five publications since 1990, with at least three of these articles first-authored. These programs of research were critiqued from a developmental science perspective. Multiple methods were used for the search, including examination of previous review articles, hand search of journals, online computer searches, and review of the curriculum vitae of authors. Seven programs of research were identified. Two programs of research focused on childhood cancer--Ida M. Martinson et al. and Marsha H. Cohen. Three programs of research used a noncategorical approach encompassing a variety of childhood chronic conditions--Katherine A. Knafl and Janet A. Deatrick, Sharon O. Burke, and Ann Garwick. One program focused primarily on parents of children with Down syndrome and disabilities--Marsha Van Riper--and another on parents of infants with a variety of chronic health problems--Margaret S. Miles and Diane Holditch-Davis. Diverse theories and conceptual frameworks were used, and most had some focus on ecological systems that might affect parents and parenting. Many used a family perspective and included fathers. Still broader aspects of the family and community ecology and the health care were not generally included. Few examined the bidirectionality of the relationship between the child and aspects of the child's illness and parental responses. There was variability in the extent to which ethnicity and socioeconomic status were considered. Studies provide important insight into the responses of parents and their parenting of children with chronic health problems. The studies provide a sound base for continuing to build a developmentally sensitive body of knowledge related to parents and parenting of the child with chronic health problems.

  7. Fuel cells: Project Volta

    Energy Technology Data Exchange (ETDEWEB)

    Vellone, R.; Di Mario, F.

    1987-09-01

    This paper discusses research and development in the field of fuel cell power plants. Reference is made to the Italian research Project Volta. Problems related to research program financing and fuel cell power plant marketing are discussed.

  8. Drosophila's contribution to stem cell research [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Gyanesh Singh

    2016-08-01

    Full Text Available The discovery of Drosophila stem cells with striking similarities to mammalian stem cells has brought new hope for stem cell research. Recent developments in Drosophila stem cell research is bringing wider opportunities for contemporary stem cell biologists. In this regard, Drosophila germ cells are becoming a popular model of stem cell research. In several cases, genes that controlled Drosophila stem cells were later discovered to have functional homologs in mammalian stem cells. Like mammals, Drosophila germline stem cells (GSCs are controlled by both intrinsic as well as external signals. Inside the Drosophila testes, germline and somatic stem cells form a cluster of cells (the hub. Hub cells depend on JAK-STAT signaling, and, in absence of this signal, they do not self-renew. In Drosophila, significant changes occur within the stem cell niche that contributes to a decline in stem cell number over time. In case of aging Drosophila, somatic niche cells show reduced DE-cadherin and unpaired (Upd proteins. Unpaired proteins are known to directly decrease stem cell number within the niches, and, overexpression of upd within niche cells restored GSCs in older males also . Stem cells in the midgut of Drosophila are also very promising. Reduced Notch signaling was found to increase the number of midgut progenitor cells. On the other hand, activation of the Notch pathway decreased proliferation of these cells. Further research in this area should lead to the discovery of additional factors that regulate stem and progenitor cells in Drosophila.

  9. Qualitative Research as Policy Knowledge: Framing Policy Problems and Transforming Education from the Ground Up

    Science.gov (United States)

    Dumas, Michael J.; Anderson, Gary

    2014-01-01

    As educational research becomes privatized, commodified and commercialized, research relevance increasingly means being incorporated into neoliberal ideological and economic agendas. Within this social context, qualitative research in particular is often deemed less relevant (if not irrelevant) because it does not provide prescriptions for best…

  10. Research on problem solving skills of orienteering athletes in terms of some variables

    Directory of Open Access Journals (Sweden)

    Eroğlu Başak

    2016-01-01

    Full Text Available The aim of this study is to examine the problem solving skills of orienteering athletes in terms of different variables. 157 male and 43 female orienteering athletes, making a total of 200 athletes that joined the 3rd Level of Turkey Championship in 2015 have participated in this study which is in a survey model. The data collection tools were the Problem Solving Inventory and Personal Information Form that were formed by Heppner & Peterson (1982 and adapted into Turkish by Şahin, Şahin & Heppner (1993. In the data analysis, descriptive statics, anova, t test and Tukey test have been utilized. In the line with the findings, it has been determined that the difference between the total mean values (85.55+20.45 that the orienteering athletes got from the problem solving inventory and their age, marital status, sports age, the years of practice in orienteering sports, and the status of being national player is significant (p<0.05. It has been found that male orienteering athletes perform higher evaluating approach compared to the female athletes, and that as the age levels increase, the problem solving skill is affected more positively. Furthermore, it has been determined that the perceptions of the participants that have more experience and sports age in orienteering sports and that do orienteering sports at a national level are more positive in the matter of problem solving skills.

  11. Topic Modeling of NASA Space System Problem Reports: Research in Practice

    Science.gov (United States)

    Layman, Lucas; Nikora, Allen P.; Meek, Joshua; Menzies, Tim

    2016-01-01

    Problem reports at NASA are similar to bug reports: they capture defects found during test, post-launch operational anomalies, and document the investigation and corrective action of the issue. These artifacts are a rich source of lessons learned for NASA, but are expensive to analyze since problem reports are comprised primarily of natural language text. We apply topic modeling to a corpus of NASA problem reports to extract trends in testing and operational failures. We collected 16,669 problem reports from six NASA space flight missions and applied Latent Dirichlet Allocation topic modeling to the document corpus. We analyze the most popular topics within and across missions, and how popular topics changed over the lifetime of a mission. We find that hardware material and flight software issues are common during the integration and testing phase, while ground station software and equipment issues are more common during the operations phase. We identify a number of challenges in topic modeling for trend analysis: 1) that the process of selecting the topic modeling parameters lacks definitive guidance, 2) defining semantically-meaningful topic labels requires nontrivial effort and domain expertise, 3) topic models derived from the combined corpus of the six missions were biased toward the larger missions, and 4) topics must be semantically distinct as well as cohesive to be useful. Nonetheless,topic modeling can identify problem themes within missions and across mission lifetimes, providing useful feedback to engineers and project managers.

  12. [Between scientific management and research-action: the problem of overconsumption of drugs in Kasongo (Zaire)].

    Science.gov (United States)

    De Brouwere, V; Van Lerberghe, W; Criel, B; Van Dormael, M

    1996-01-01

    A Primary Health Care (PHC) system may be effective and efficient to the extent that essential drugs are available in health services and financially accessible to the population. In developing countries, besides the difficulties related to supplying health services with adequate amounts of drugs, the control of drug consumption is one of the frequent problems encountered by health authorities. Literature is relatively abundant in the field of rationalization of the diagnosis and drug prescription processes, and also in the field of drug financing mechanisms; publications are however rather scarce when topics related to corruption or drug misappropriation are concerned. The case study submitted hereafter reports a drug overconsumption problem in the health centres (HC) of the Kasongo district (Zaire). Despite the existence of direct control mechanisms as well as indirect ones (monitoring of drug consumption by HC), the problem has been identified belatedly. The district staff then used a step-by-step analysis of the HC drug consumption profiles; this analysis allowed to demonstrate that misappropriation would be the most plausible hypothesis. In order to solve the misappropriation problem-the consequences of which jeopardized the functioning of the very health system-the district staff chose to involve the nurses, in charge of the HC, in the entire problem-solving process. This participative approach, involving different actors as partners, allowed to deepen the situation analysis and to elaborate solutions congruent with PHC principles and acceptable to all concerned.

  13. Research on a Unique Instructional Framework for Elevating Students’ Quantitative Problem Solving Abilities

    Science.gov (United States)

    Prather, Edward E.; Wallace, Colin Scott

    2018-06-01

    We present an instructional framework that allowed a first time physics instructor to improve students quantitative problem solving abilities by more than a letter grade over what was achieved by students in an experienced instructor’s course. This instructional framework uses a Think-Pair-Share approach to foster collaborative quantitative problem solving during the lecture portion of a large enrollment introductory calculus-based mechanics course. Through the development of carefully crafted and sequenced TPS questions, we engage students in rich discussions on key problem solving issues that we typically only hear about when a student comes for help during office hours. Current work in the sophomore E&M course illustrates that this framework is generalizable to classes beyond the introductory level and for topics beyond mechanics.

  14. A simulation based research on chance constrained programming in robust facility location problem

    Directory of Open Access Journals (Sweden)

    Kaijun Leng

    2017-03-01

    Full Text Available Since facility location decisions problem include long-term character and potential parameter variations, it is important to consider uncertainty in its modeling. This paper examines robust facility location problem considering supply uncertainty, in which we assume the supply of the facility in the actual operation is not equal to the supply initially established, the supply is subject to random fluctuation. The chance constraints are introduced when formulating the robust facility location model to make sure the system operate properly with a certain probability while the supply fluctuates. The chance constraints are approximated safely by using Hoeffding’s inequality and the problem is transformed to a general deterministic linear programming. Furthermore, how the facility location cost change with confidence level is investigated through a numerical example. The sensitivity analysis is conducted for important parameters of the model and we get the main factors that affect the facility location cost.

  15. Some physical problems in biology: Aspects of the origin and structure of the first cell

    International Nuclear Information System (INIS)

    Chela Flores, J.

    1995-01-01

    A review is presented within the framework of the theory of evolution, after it has been extrapolated from the population level to the cellular and molecular levels. From Darwin's seminal and persuasive insight - the theory of common descent - we assume, with him, that ''probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed''. We are now aware that his primordial cell may have been a protocyanobacterium, but it has often been called 'a last universal ancestor', a 'breakthrough organism', or a 'progenote', a term introduced by Woese which has gained wide acceptance. Strictly speaking, in the 'intermediate period', ranging from the first living cell to the progenote, life may have evolved in the absence of significant diversity, effectively as a single phylum, incorporating organisms whose genetic systems were already based on DNA. Earlier still, prior to the encapsulation of nucleic acids in microspheres, evolution may already have been at work on RNA molecules (the 'RNA world'). This takes our discussion into the period of chemical evolution, a concept first put forward by Oparin, whose principal merit is to have formulated the underlying problem in clear scientific terms. This review does not attempt to be comprehensive. It is mainly devoted to the discussion of certain concepts that may have played a relevant role in the pathway that led to the origin and evolution of the progenote. We do not dwell on the main events of the intermediate period. The topic that we have chosen to include are: the origin of chirality of protein amino acids, the origin of translation, and the origin of the genome. We conclude with some comments on one further aspect of the evolutionary process - the development of biodiversity - by considering the origin of the first eukaryotic cell, an event which, according to the fossil record, may have preceded the evolutionary radiation in the early

  16. Trends in the history of research on the problem of violence in the Old Testament

    Directory of Open Access Journals (Sweden)

    S. D. Snyman

    1997-08-01

    Full Text Available Violence as theological problem is a relative newcomer to the scene of Old Testament studies. It was only during the 1970�s that violence was given major attention by Old Testament scholars. In a number of studies the main focus was on Yahweh and his relation to violence. By the late I970�s the theories of Rene Girard on violence were applied to the Old Testament and played an important role in the thinking of Old Testament scholars on violence. In the last part of the article proposed solutions to the problem of violence in the Old Testament are discussed.

  17. Ethical issues in implementation research: a discussion of the problems in achieving informed consent

    Directory of Open Access Journals (Sweden)

    Eccles Martin P

    2008-12-01

    Full Text Available Abstract Background Improved quality of care is a policy objective of health care systems around the world. Implementation research is the scientific study of methods to promote the systematic uptake of clinical research findings into routine clinical practice, and hence to reduce inappropriate care. It includes the study of influences on healthcare professionals' behaviour and methods to enable them to use research findings more effectively. Cluster randomized trials represent the optimal design for evaluating the effectiveness of implementation strategies. Various codes of medical ethics, such as the Nuremberg Code and the Declaration of Helsinki inform medical research, but their relevance to cluster randomised trials in implementation research is unclear. This paper discusses the applicability of various ethical codes to obtaining consent in cluster trials in implementation research. Discussion The appropriate application of biomedical codes to implementation research is not obvious. Discussion of the nature and practice of informed consent in implementation research cluster trials must consider the levels at which consent can be sought, and for what purpose it can be sought. The level at which an intervention is delivered can render the idea of patient level consent meaningless. Careful consideration of the ownership of information, and rights of access to and exploitation of data is required. For health care professionals and organizations, there is a balance between clinical freedom and responsibility to participate in research. Summary While ethical justification for clinical trials relies heavily on individual consent, for implementation research aspects of distributive justice, economics, and political philosophy underlie the debate. Societies may need to trade off decisions on the choice between individualized consent and valid implementation research. We suggest that social sciences codes could usefully inform the consideration of

  18. Bully/Victim Problems among Preschool Children: A Review of Current Research Evidence

    Science.gov (United States)

    Vlachou, Maria; Andreou, Eleni; Botsoglou, Kafenia; Didaskalou, Eleni

    2011-01-01

    Bullying in schools has been identified as a serious and complex worldwide problem associated with negative short- and long-term effects on children's psychosocial adjustment (Smith 1999; Ttofi and Farrington, "Aggressive Behav" 34(4):352-368, 2008). Entering kindergarten is a crucial developmental step in many children's lives mainly because it…

  19. Information problem solving instruction: An overview of 21st century research

    NARCIS (Netherlands)

    Wopereis, Iwan; Frerejean, Jimmy; Testers, Laurent; Van Strien, Johan; Walhout, Jaap; Brand-Gruwel, Saskia

    2015-01-01

    Information problem solving (IPS) is the process of locating, selecting, evaluating, and integrating information from various sources to fulfill an information need (Brand-Gruwel, Wopereis, & Vermetten, 2005). It is regarded an important contemporary skill, at times categorized as twenty-first

  20. Exploring quantum mechanics a collection of 700+ solved problems for students, lecturers, and researchers

    CERN Document Server

    Galitski, Victor; Kogan, Vladimir; Galitski, Victor Jr

    2013-01-01

    A series of seminal technological revolutions has led to a new generation of electronic devices miniaturized to such tiny scales where the strange laws of quantum physics come into play. There is no doubt that, unlike scientists and engineers of the past, technology leaders of the future will have to rely on quantum mechanics in their everyday work. This makes teaching and learning the subject of paramount importance for further progress. Mastering quantum physics is a very non-trivial task and its deep understanding can only be achieved through working out real-life problems and examples. It is notoriously difficult to come up with new quantum-mechanical problems that would be solvable with a pencil and paper, and within a finite amount of time. This book remarkably presents some 700+ original problems in quantum mechanics together with detailed solutions covering nearly 1000 pages on all aspects of quantum science. The material is largely new to the English-speaking audience. The problems have been collect...

  1. [Pollution-ecological problems of old industrial and mining areas and future research prospects].

    Science.gov (United States)

    Zhou, Qixing

    2005-06-01

    Environmental pollution and its solicitation in ecological problems of old industrial and mining areas have become a worldwide technological puzzle restricting sustainable economic and social development. But, the definition and category of old industrial and mining areas is still disputed as an important concept. In this paper, the concept of old industrial and mining area was discussed in theory, and, proceeded with analyzing the complexity of current situation and environmental pollution problems of old industrial and mining areas in China, more keystone attention was paid to the secondary pollution problems from old industrial and mining areas as an important frontier of science. On the basis of expounding the complexity and characters of environmental pollution in old industrial and mining areas, it was suggested that as two key scientific problems in environmental sciences and ecology, the formation mechanisms and control technology of secondary pollution in old industrial and mining areas and the responses of new-type diseases to environmental pollution based on molecular ecotoxicology should be systematically studied on the national scale, and be an important component of environmental protection strategy in China in the future.

  2. Self-Monitoring Interventions for Students with Behavior Problems: A Systematic Review of Current Research

    Science.gov (United States)

    Bruhn, Allison; McDaniel, Sara; Kreigh, Christi

    2015-01-01

    Explicitly teaching skills associated with self-determination has been promoted to support students' independence and control over their own lives. This is especially important for students with behavior problems. One self-determination skill or behavior that has been studied widely is self-monitoring. Although multiple reviews of various…

  3. Update on Research and Application of Problem-Based Learning in Medical Science Education

    Science.gov (United States)

    Fan, Chuifeng; Jiang, Biying; Shi, Xiuying; Wang, Enhua; Li, Qingchang

    2018-01-01

    Problem-based learning (PBL) is a unique form of pedagogy dedicated to developing students' self-learning and clinical practice skills. After several decades of development, although applications vary, PBL has been recognized all over the world and implemented by many medical schools. This review summarizes and updates the application and study of…

  4. Agent-Based Modeling of Collaborative Problem Solving. Research Report. ETS RR-16-27

    Science.gov (United States)

    Bergner, Yoav; Andrews, Jessica J.; Zhu, Mengxiao; Gonzales, Joseph E.

    2016-01-01

    Collaborative problem solving (CPS) is a critical competency in a variety of contexts, including the workplace, school, and home. However, only recently have assessment and curriculum reformers begun to focus to a greater extent on the acquisition and development of CPS skill. One of the major challenges in psychometric modeling of CPS is…

  5. A New Method for Research on the Center-Focus Problem of Differential Systems

    OpenAIRE

    Zhou, Zhengxin

    2014-01-01

    We will introduce Mironenko’s method to discuss the Poincaré center-focus problem, and compare the methods of Lyapunov and Mironenko. We apply the Mironenko method to discuss the qualitative behavior of solutions of some planar polynomial differential systems and derive the sufficient conditions for a critical point to be a center.

  6. Augmented Reality in Turkey with Researchers' Comments for Educational Use: Problems, Solutions and Suggestions

    Science.gov (United States)

    Akgün, Özcan Erkan; Istanbullu, Aslihan; Avci, Sirin Küçük

    2017-01-01

    Augmented reality (AR) is a technology to supplement existing reality with additional information, descriptions and helpful images with the help of technology and therefore ensure the reality to be perceived more qualified and well-rounded. In this study, views and comments about problems, solutions and suggestions on using AR were gathered from…

  7. Problems and challenges in care for children undergoing radiotherapy- A research paper

    International Nuclear Information System (INIS)

    Mucheusi, L.

    2006-01-01

    for children undergoing radiotherapy and their parents, a paediatric radiographer may be one welcome solution to relieve the anxiety and stress during this difficult time in their lives. given the various factors, no one solution can be deemed ultimate in dealing with this complex situation. thus further efforts are needed to bring about workable solutions to this problem depending on the circumstances and situation

  8. Commentary on: Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research. Problems with atheoretical and confirmatory research approaches in the study of behavioral addictions.

    Science.gov (United States)

    Kardefelt-Winther, Daniel

    2015-09-01

    This commentary is written in response to a paper by Billieux, Schimmenti, Khazaal, Maurage and Hereen (2015) published in the Journal of Behavioral Addictions. It supports and extends the arguments by Billieux, Schimmenti et al. (2015): that the study of behavioral addictions too often rests on atheoretical and confirmatory research approaches. This tends to lead to theories that lack specificity and a neglect of the underlying processes that might explain why repetitive problem behaviors occur. In this commentary I extend the arguments by Billieux, Schimmenti et al. (2015) and argue that such research approaches might take us further away from conceptualizing psychiatric diagnoses that can be properly validated, which is already a problem in the field. Furthermore, I discuss whether the empirical support for conceptualizing repetitive problem behaviors as addictions might rest on research practices that have been methodologically biased to produce a result congruent with the proposal that substance addictions and behavioral addictions share similar traits. I conclude by presenting a number of ways of going forward, chief of which is the proposal that we might wish to go beyond a priori assumptions of addiction in favor of identifying the essential problem manifestations for each new potential behavioral addiction.

  9. [Ethics in clinical research: contextualizing and reductionist problem definitions, forms of ethical reflection and some particular implications].

    Science.gov (United States)

    Roelcke, Volker

    2003-12-01

    The present paper starts off with a short outline of issues, conflicts, and goals of ethical reflection about clinical research. It is then argued that non-reductionist, patient-centred ethics should critically reflect on medically preformed problem definitions, ways of problem solution, and evaluations. The shortcomings of such preformed perceptions and interpretations are illustrated using the examples of dementia research, and the complexities of the notion of risk. A more comprehensive approach including the perceptions, interpretations, and evaluations of the patients' perspective necessitates a form of ethical reflection which takes into account the social and cultural contexts of clinical research, and which therefore relies on concepts and methods of the cultural sciences (in particular history, sociology, and cultural anthropology). The decision for a reductionist, or for a contextualising mode of ethical reflection represents in itself a value decision and needs to be explicitly justified.

  10. Corrosion Induced Leakage Problem of the Radial Beam Port 1 of BAEC Triga Mark-II Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kalam, A.; Salam, M. A.; Sarder, M. A.; Rahman, M. M.; Rahman, M.; Rahman, A.; Chowdhury, A. Z.; Uddin, M. S.; Haque, M. M.; Zulquarnain, M.A., E-mail: kalambaec@yahoo.com [Reactor Operation and Maintenance Unit, Atomic Energy Research Establishment (AERE), Dhaka (Bangladesh)

    2014-08-15

    The BAEC reactor has so far been operated as per the technical specifications and procedures laid down in the SAR of the research reactor. The BP leakage problem of the BAEC research reactor was an issue that could lead to a situation close to a LOCA. Therefore, the matter was handled carefully, taking all measures so that such an incident could be prevented. Assistance of agencies outside BAEC was taken for solving the problem. It is understood that the silicone rubber lining of the encirclement clamp may become damaged by neutron irradiation. Therefore, while designing the clamp, provisions were kept such that it can be dismantled and reinstalled again following lining replacement. As a moderately aged facility, the ageing management BAEC TRIGA research reactor deserves significant attention. BAEC, together with its strategic partners, are doing what is needed in this regard.

  11. Survey of editors and reviewers of high-impact psychology journals: statistical and research design problems in submitted manuscripts.

    Science.gov (United States)

    Harris, Alex; Reeder, Rachelle; Hyun, Jenny

    2011-01-01

    The authors surveyed 21 editors and reviewers from major psychology journals to identify and describe the statistical and design errors they encounter most often and to get their advice regarding prevention of these problems. Content analysis of the text responses revealed themes in 3 major areas: (a) problems with research design and reporting (e.g., lack of an a priori power analysis, lack of congruence between research questions and study design/analysis, failure to adequately describe statistical procedures); (b) inappropriate data analysis (e.g., improper use of analysis of variance, too many statistical tests without adjustments, inadequate strategy for addressing missing data); and (c) misinterpretation of results. If researchers attended to these common methodological and analytic issues, the scientific quality of manuscripts submitted to high-impact psychology journals might be significantly improved.

  12. A problem-based approach to teaching research methodology to medical graduates in Iran

    Directory of Open Access Journals (Sweden)

    Mehrdad Jalalian Hosseini

    2009-08-01

    Full Text Available Physicians are reticent to participate in research projects for avariety of reasons. Facilitating the active involvement ofdoctors in research projects is a high priority for the IranianBlood Transfusion Organization (IBTO. A one-month trainingcourse on research methodology was conducted for a groupof physicians in Mashhad, in northeast Iran. The participantswere divided in ten groups. They prepared a researchproposal under the guidance of a workshop leader. Thequality of the research proposals, which were prepared by allparticipants, went beyond our expectations. All of theresearch proposals were relevant to blood safety. In this briefreport we describe our approach.

  13. Open science, e-science and the new technologies: Challenges and old problems in qualitative research in the social sciences

    Directory of Open Access Journals (Sweden)

    Ercilia García-Álvarez

    2012-12-01

    Full Text Available Purpose: As well as introducing the articles in the special issue titled "Qualitative Research in the Social Sciences", this article reviews the challenges, problems and main advances made by the qualitative paradigm in the context of the new European science policy based on open science and e-Science and analysis alternative technologies freely available in the 2.0 environment and their application to fieldwork and data analysis. Design/methodology: Theoretical review. Practical implications: The article identifies open access technologies with applications in qualitative research such as applications for smartphones and tablets, web platforms and specific qualitative data analysis software, all developed in both the e-Science context and the 2.0 environment. Social implications: The article discusses the possible role to be played by qualitative research in the open science and e-Science context and considers the impact of this new context on the size and structure of research groups, the development of truly collaborative research, the emergence of new ethical problems and quality assessment in review processes in an open environment. Originality/value: The article describes the characteristics that define the new scientific environment and the challenges posed for qualitative research, reviews the latest open access technologies available to researchers in terms of their main features and proposes specific applications suitable for fieldwork and data analysis.

  14. State performance in pluripotent and adult stem cell research, 2009-2016.

    Science.gov (United States)

    Surani, Sana H; Levine, Aaron D

    2018-04-01

    To examine how the geographic distribution of pluripotent and adult stem cell research publications within the USA differs from other areas of biomedical research. Publication count data for pluripotent stem cell research, adult stem cell research and a comparison group representative of biomedical research more broadly were collected and analyzed for each US state from 2009 to 2016. The distribution of pluripotent stem cell research differed from the other fields with overperformance in pluripotent stem cell research observed in California, as well as Wisconsin, Massachusetts, Maryland and Connecticut. Our analysis suggests that permissive state stem cell policy may be one of the several factors contributing to strong state performance in pluripotent stem cell research.

  15. HISTORICAL-PEDAGOGICAL ANALYSIS OF THE PROBLEM OF DEVELOPING RESEARCH SKILLS IN STUDENTS, AS A FACTOR IN EFFECTIVE LEARNING

    Directory of Open Access Journals (Sweden)

    Marianna Albertovna Gorodilova

    2016-02-01

    Full Text Available A special form of the process of cognition this study, i.e. targeted and systematic study that uses the tools of science, and which results in the formation of knowledge about the studied objects. In a broad sense, research is the search for new knowledge. On the other hand (in the narrow sense research is a scientific method of studying something. Cognitive abilities of students based on the ability to «explore».The aim of our study is the problem of formation and development of research skills among students. These skills characterize many kinds of activities corresponding to different levels of professionalism. The development of research skills determines the success of the training. Methodical skill of the teacher is manifested, not only in dealing with certain tasks of teaching, but rather in how these tasks are solved. Without knowledge of historical and pedagogical heritage is impossible to solve the problem of development of research skills in the students.The article conducts historical and pedagogical analysis of literary sources on the problem of developing research skills in students. Considered certain periods in the formation process of formation and development of research abilities of students during their education. This idea existed not in isolation, but in the General system of other Sciences, especially mathematics and philosophy and relevant is not a single century. Changing pedagogical approaches to the implementation of this idea, as changing the conditions of teaching and the individual characteristics of students. But to form and develop in students the ability to think independently, implement research – one of methods of successful training.

  16. Our Anonymous Online Research Participants Are Not Always Anonymous: Is This a Problem?

    Science.gov (United States)

    Dawson, Phillip

    2014-01-01

    When educational research is conducted online, we sometimes promise our participants that they will be anonymous--but do we deliver on this promise? We have been warned since 1996 to be careful when using direct quotes in Internet research, as full-text web search engines make it easy to find chunks of text online. This paper details an empirical…

  17. Nematode parasites of fishes: recent advances and problems of their research

    Czech Academy of Sciences Publication Activity Database

    Moravec, František

    2007-01-01

    Roč. 49, č. 3 (2007), s. 155-160 ISSN 0048-2951 R&D Projects: GA ČR(CZ) GA524/06/0170; GA MŠk LC522 Institutional research plan: CEZ:AV0Z60220518 Keywords : parasitic nematode * research * fish Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine

  18. Ethical problems in health research with indigenous or originary peoples in Peru.

    Science.gov (United States)

    Minaya, Gabriela; Roque, Joel

    2015-07-01

    The varied, abrupt and amazing geography of the land of Peru is home of one of the major concentrations of indigenous peoples in the world. The asymmetry of power, however, in their relationship with the rest of society and the State is still very evident in their social exclusion, their gap in social and economic development, barriers in their access to health services as well as their marginalization and exploitation as subjects of health research. In this paper, we analyse two cases of research on indigenous populations in Peru, discuss them from the point of view of bioethics and reflect on important issues for researchers, research participants and the society, such as the need to respect different cultures, the need that the research being done is relevant to the needs of the population in which it is conducted and the necessity to empower indigenous communities in participatory research, to strengthen the institutions and to protect human rights, namely through ethics committees for research and the free, informed and meaningful informed consent. This approach should foster quality research, while at the same time fully respecting human rights and bioethics. We cannot forget that advancements in genetics, throughout the world, are very much in debt to indigenous populations.

  19. Inter- and Transdisciplinary Work: Connecting Research on Hormones with Problems of Educational Practice

    Science.gov (United States)

    Rappolt-Schlichtmann, Gabrielle; Watamura, Sarah E.

    2010-01-01

    More than ever before, leaders within the field of education are looking to research on basic processes to inform and improve educational practices. Success requires building a reciprocal relationship between the field of education and research on learning and development, similar to what exists between biology and medicine. Key to this effort is…

  20. Twenty Years of Cultural Imperialism Research: Some Conceptual and Methodological Problems.

    Science.gov (United States)

    Burrowes, Carl Patrick

    While the notion of "cultural imperialism" has received significant attention in communication studies since the early 1970s, researchers have ignored analyses of message systems and audience cultivation in favor of institutional analysis. Likewise, researchers have concentrated on the technologies, media products and processes of…

  1. RESEARCH ON THE LEGAL PROBLEMS OF THE PORT MANAGEMENT SYSTEM IN JAPAN

    OpenAIRE

    TAKAHASHI, Koji; KASUGAI, Yasuo; FUKUDA, Isao

    2014-01-01

    Across the world, port management is increasingly adopting a scheme of separatinginfrastructure and operations. In the midst of this global trend, Japan experienced the Great Hanshin andAwaji Earthquake in 1995 and the Great East Japan Earthquake in 2011, both of which devastated majorports, forcing Japan to face challenges related to its port management system. In addition, with majorearthquakes expected to strike again in the future, it is urgent for Japan to solve the current problems. Jap...

  2. Overview of research trends and problems on Cr-Mo low alloy steels for pressure vessel

    International Nuclear Information System (INIS)

    Chi, Byung Ha; Kim, Jeong Tae

    2000-01-01

    Cr-Mo low alloy steels have been used for a long time for pressure vessel due to its excellent corrosion resistance, high temperature strength and toughness. The paper reviewed the latest trends on material development and some problems on Cr-Mo low alloy steel for pressure vessel, such as elevated temperature strength, hardenability, synergetic effect between temper and hydrogen embrittlement, hydrogen attack and hydrogen induced disbonding of overlay weld-cladding

  3. High-level-waste containment for a thousand years: unique technical and research problems

    International Nuclear Information System (INIS)

    Davis, M.S.

    1982-01-01

    In the United States the present policy for disposal of high level nuclear wastes is focused on isolation of solidified wastes in a mined geologic repository. Safe isolation is to be achieved by utilizing both natural and man-made barriers which will act in concert to assure the overall conservative performance of the disposal system. The incorporation of predictable man-made barriers into the waste disposal strategy has generated some new and unique problems for the scientific community

  4. Addressing the critical health problem of adolescent substance use through health care, research, and public policy.

    Science.gov (United States)

    Feinstein, Emily C; Richter, Linda; Foster, Susan E

    2012-05-01

    The use of addictive substances-tobacco, alcohol, and other drugs-during adolescence interferes with brain development and increases the risk of serious health and mental health conditions, including addiction. Yet, adolescents live in a culture in which family, social, community, and media influences regularly bombard them with pro-substance use messages, creating an environment in which substance use is considered an expected behavior, rather than a considerable health risk. To prevent the significant harm that falls to teens and young adults because of substance use, The National Center on Addiction and Substance Abuse at Columbia University (CASA Columbia) undertook a study to explore how adolescent brain development relates to the risk of substance use and addiction; the cultural influences that create an environment in which substance use is considered normative behavior; individual factors that make some teens more disposed to substance use and addiction; and evidence-based prevention and treatment strategies for addressing this problem. The recently published report Adolescent Substance Use: America's #1 Public Health Problem concludes that risky substance use is a major public health problem that can be ameliorated through evidence-based public health measures, including education about the disease and its risk factors, screenings, and clinical interventions, and that addiction can be treated and managed effectively within routine health care practice and specialty care. Copyright © 2012 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  5. Data-Intensive Cloud Service Provision for Research Institutes: the Network Connectivity Problem

    CERN Document Server

    Cass, Tony; CERN. Geneva. IT Department

    2016-01-01

    Much effort (and money) has been invested in recent years to ensure that academic and research sites are well interconnected with high-capacity networks that, in most cases, span national and continental boundaries. However, these dedicated research and education networks, whether national (NRENs) or trans-continental (RENs), frequently have Acceptable Use Policies (AUPs) that restrict their use by commercial entities, notably Cloud Service Providers (CSPs). After a brief summary of the issues involved, we describe three approaches to removing the network connectivity barrier that threatens to limit the ability of academic and research institutions to profit effectively from services offered by CSPs.

  6. Decommissioning of the research nuclear reactor IRT-M and problems connected with radioactive waste

    International Nuclear Information System (INIS)

    Abramidze, S.P.; Katamadze, N.M.; Kiknadze, G.G.; Saralidze, Z.K.

    2000-01-01

    The nuclear research reactor IRT-2000 is described, along with modifications and upgrades made over the past three decades. Considerations are outlined which followed a decision to shut-down the reactor and to dismantle it. (author)

  7. Workshop to review problem-behavior research programs : pedestrian, bicycle, and pupil transportation safety

    Science.gov (United States)

    1981-09-01

    This report presents the proceedings of a workshop on pedestrian, bicycle, and pupil transportation safety. The purpose of this workshop was to develop specific recommendations for the planning and implementation of NHTSA research, development, and d...

  8. Numerical research of the optimal control problem in the semi-Markov inventory model

    Energy Technology Data Exchange (ETDEWEB)

    Gorshenin, Andrey K. [Institute of Informatics Problems, Russian Academy of Sciences, Vavilova str., 44/2, Moscow, Russia MIREA, Faculty of Information Technology (Russian Federation); Belousov, Vasily V. [Institute of Informatics Problems, Russian Academy of Sciences, Vavilova str., 44/2, Moscow (Russian Federation); Shnourkoff, Peter V.; Ivanov, Alexey V. [National research university Higher school of economics, Moscow (Russian Federation)

    2015-03-10

    This paper is devoted to the numerical simulation of stochastic system for inventory management products using controlled semi-Markov process. The results of a special software for the system’s research and finding the optimal control are presented.

  9. Numerical research of the optimal control problem in the semi-Markov inventory model

    International Nuclear Information System (INIS)

    Gorshenin, Andrey K.; Belousov, Vasily V.; Shnourkoff, Peter V.; Ivanov, Alexey V.

    2015-01-01

    This paper is devoted to the numerical simulation of stochastic system for inventory management products using controlled semi-Markov process. The results of a special software for the system’s research and finding the optimal control are presented

  10. Experiments in Laboratory of Nuclear Problems of Joint Institute for Nuclear Research in 1994-1995

    International Nuclear Information System (INIS)

    Bednyakov, V.A.

    1994-01-01

    This book is a complication of the short status reports on current experiments on intermediate energy physics and on high energy physics. The projects of new facilities and the results of radiobiological researches are presented

  11. A mathematical approach to research problems of science and technology theoretical basis and developments in mathematical modeling

    CERN Document Server

    Ei, Shin-ichiro; Koiso, Miyuki; Ochiai, Hiroyuki; Okada, Kanzo; Saito, Shingo; Shirai, Tomoyuki

    2014-01-01

    This book deals with one of the most novel advances in mathematical modeling for applied scientific technology, including computer graphics, public-key encryption, data visualization, statistical data analysis, symbolic calculation, encryption, error correcting codes, and risk management. It also shows that mathematics can be used to solve problems from nature, e.g., slime mold algorithms. One of the unique features of this book is that it shows readers how to use pure and applied mathematics, especially those mathematical theory/techniques developed in the twentieth century, and developing now, to solve applied problems in several fields of industry. Each chapter includes clues on how to use "mathematics" to solve concrete problems faced in industry as well as practical applications. The target audience is not limited to researchers working in applied mathematics and includes those in engineering, material sciences, economics, and life sciences.

  12. Research Problems Associated with Limiting the Applied Force in Vibration Tests and Conducting Base-Drive Modal Vibration Tests

    Science.gov (United States)

    Scharton, Terry D.

    1995-01-01

    The intent of this paper is to make a case for developing and conducting vibration tests which are both realistic and practical (a question of tailoring versus standards). Tests are essential for finding things overlooked in the analyses. The best test is often the most realistic test which can be conducted within the cost and budget constraints. Some standards are essential, but the author believes more in the individual's ingenuity to solve a specific problem than in the application of standards which reduce problems (and technology) to their lowest common denominator. Force limited vibration tests and base-drive modal tests are two examples of realistic, but practical testing approaches. Since both of these approaches are relatively new, a number of interesting research problems exist, and these are emphasized herein.

  13. Present status of design, research and development of nuclear fusion reactors and problems

    International Nuclear Information System (INIS)

    1983-04-01

    Seven years have elapsed since the publication of ''Progress of nuclear fusion research and perspective toward the development of power reactors'' by the Atomic Energy Society of Japan in August, 1976. During this period, the research and development of nuclear fusion have changed from plasma physics to reactor technology, being conscious of the realization of fusion reactors. There are the R project in the Institute of Plasma Physics, Nagoya University, and the design and construction of JT-60 in Japan Atomic Energy Research Institute, to put it concretely. Now the research and development taking the economical efficiency into account are adopted. However, the type of fusion reactors is not reduced to tokamak type, accordingly the research and development to meet the diverse possibilities are forwarded. The progress of tokamak reactor research, core plasma design, nuclear design and shielding design, thermal structure design, the design of superconducting magnets, disassembling and repair, safety, economical efficiency, the conceptual design of other types than tokamak and others are reported. (Kako, I.)

  14. Present status of research activities relating global warming problems in Japan (mainly MITI and relating organizations)

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, O.

    1993-12-31

    Japanese government has issued action program so called {open_quotes}Action Program to Arrest Global Warming{close_quotes} for preventing global warming at Oct., 1990. According to the program, CO{sub 2} emission should be stabilized on a per capita basis in the year 2000 and beyond at about same level as in 2000 by introducing several methods such as energy conservation, improvement of energy using efficiency, expanding use of renewable energy and so on. The basic concept, target and methods are summarized. At the same time, MITI published so called {open_quotes}New Earth 21{close_quotes} project which aims remedying the earth environment modified by human activities since industrial innovation began at about 200 years ago in coming 100 years. This plan proposed yearly step of research development of technology for mitigating CO{sub 2} emission. According to the MITI`s plan, 15 institutions belonging to AIST have carrying research for developing technology of reducing emission of CO{sub 2} and other greenhouse gases, with cooperation of other research organizations such as RITE (research Institute of Innovative Technology for Earth) and NEDO (New Energy and Industrial Technology Developing Organization). Time schedule of the research development by The New Earth 21 project is summarized in Table 2. Now, in Japan, many national institutions and universities, research works relating reduction and mitigation of GHG are carried out according to this guideline.

  15. Being relevant: Practical guidance for early career researchers interested in solving conservation problems

    Directory of Open Access Journals (Sweden)

    J.M. Chapman

    2015-07-01

    Full Text Available In a human-altered world where biodiversity is in decline and conservation problems abound, there is a dire need to ensure that the next generation of conservation scientists have the knowledge, skills, and training to address these problems. So called “early career researchers” (ECRs in conservation science have many challenges before them and it is clear that the status quo must change to bridge the knowledge–action divide. Here we identify thirteen practical strategies that ECRs can employ to become more relevant. In this context, “relevance” refers to the ability to contribute to solving conservation problems through engagement with practitioners, policy makers, and stakeholders. Conservation and career strategies outlined in this article include the following: thinking ‘big picture’ during conservation projects; embracing various forms of knowledge; maintaining positive relationships with locals familiar with the conservation issue; accepting failure as a viable (and potentially valuable outcome; daring to be creative; embracing citizen science; incorporating interdisciplinarity; promoting and practicing pro-environmental behaviours; understanding financial aspects of conservation; forming collaboration from the onset of a project; accepting the limits of technology; ongoing and effective networking; and finally, maintaining a positive outlook by focusing on and sharing conservation success stories. These strategies move beyond the generic and highlight the importance of continuing to have an open mind throughout the entire conservation process, from establishing one’s self as an asset to embracing collaboration and interdisciplinary work, and striving to push for professional and personal connections that strengthen personal career objectives.

  16. CONSERVATION CHILD’S ATTACHMENT TO BOTH PARENTS IN THE DIVORCE: ON THE PROBLEM RESEARCH

    OpenAIRE

    Sklyarova, Tatyana; Kupriianova, Elena

    2017-01-01

    his paper discusses the development of a child whose parents are divorced. In deciding with whom the child should stay, the court is based on his interests, it is very often decisive is the child's own opinion about who he wants to live. An important problem in this situation is the active influence of one parent (most of whom currently live child) on the decision-making process a child. To achieve the desired result the parent often resorted to negative methods of influence on your child, cr...

  17. Research on consumable distribution mode of shipbuilder’s shop based on vehicle routing problem

    Directory of Open Access Journals (Sweden)

    Xiang Su

    2017-02-01

    Full Text Available A distribution vehicle optimization is established with considerations for the problem of long period of requisition and high shop costs due to the existing consumable requisition mode in shipbuilder’s shops for the requirements of shops for consumables. The shortest traveling distance of distribution vehicles are calculated with the genetic algorithm (GA. Explorations are made into a shop consumable distribution mode for shipbuilders to help them to effectively save their production logistics costs, enhance their internal material management level and provide reference for shipbuilder’s change in traditional ways and realization of just-in-time (JIT production.

  18. Design of a Maglev Vibration Test Platform for the Research of Maglev Vehicle-girder Coupled Vibration Problem

    Directory of Open Access Journals (Sweden)

    Zhou Danfeng

    2017-01-01

    Full Text Available The maglev vehicle-girder coupled vibration problem has been encountered in many maglev test or commercial lines, which significantly degrade the performance of the maglev train. In previous research on the principle of the coupled vibration problem, it has been discovered that the fundamental model of the maglev girder can be simplified as a series of mass-spring resonators of different but related resonance frequencies, and that the stability of the vehicle-girder coupled system can be investigated by separately examining the stability of each mass-spring resonator – electromagnet coupled system. Based on this conclusion, a maglev test platform, which includes a single electromagnetic suspension control system, is built for experimental study of the coupled vibration problem. The guideway of the test platform is supported by a number of springs so as to change its flexibility. The mass of the guideway can also be changed by adjusting extra weights attached to it. By changing the flexibility and mass of the guideway, the rules of the maglev vehicle-girder coupled vibration problem are to be examined through experiments, and related theory on the vehicle-girder self-excited vibration proposed in previous research is also testified.

  19. Way Search to Research: from Academic Exercises in Architecture to Scientific Investigations into Actual Problems

    Directory of Open Access Journals (Sweden)

    Gintaras Stauskis

    2012-05-01

    Full Text Available Abstract. An interest in doctoral studies reflects the overall status of the scientist in the country in general and the role of science in the architect profession in particular. The article analyses the basic channels of how the students of architecture search for and find the ways to transfer themselves from the study area into an academic research environment. In order to figure out general trends and to outline the differences and similarities of doctoral studies that could further facilitate cooperation, the paper presents the thematic outputs of doctoral programmes in architecture schools in Vilnius, Riga, Venice, Jelgava and Weimar. With reference to the example of the Faculty of Architecture, VGTU, the trends towards developing research activities are analysed taking into account three interconnected branches of architecture: urban design, building architecture and landscape architecture. The cooperation and coordination of academic and research activities in wider European space is taking place upon common interest based on the specificities of each school and priorities of the chosen region. The awareness of global and regional processes in architectural research is an important point for the present and coming generations of researchers in Europe as they are building their careers on the basis of investigation into the options of the local applications of global competences in a cross-professional and inter-disciplinary way.

  20. Employment of Questionnaire as Tool for Effective Business Research Outcome: Problems and Challenges

    Directory of Open Access Journals (Sweden)

    ADENIYI AKINGBADE WAIDI

    2016-06-01

    Full Text Available Questionnaire has to do with questions designed to gather information or data for analysis. Questionnaire has to be adequate, simple, focused and related to the subject which the research is set to achieve and to test the hypotheses and questions that are formulated for the study. But many questionnaires are constructed and administered without following proper guideline which hinders there end result. This paper assesses some of the guides for constructing questionnaire as well as it uses and the extent to which it enhanced manager’s access to reliable data and information. Descriptive method is employed for the study. Findings revealed that poor or badly prepared questionnaire produce questionnaire that does not provide effective results. Managers and researchers that use such questionnaire hardly achieve their organisational and research objectives. The need for good, well prepared and adequate questionnaire is exemplified by its being the primary tool for analytical research. The study recommends that questionnaire be properly prepared for effective research outcome.

  1. Technical problems in case of utilizing uranium of medium enrichment for a research reactor

    International Nuclear Information System (INIS)

    Kanda, Keiji; Shibata, Shun-ichi

    1979-01-01

    Usually, highly enriched uranium of 90 - 93% is used for research reactors, but the US government proposed the strong policy to use low enriched uranium of the uranium of medium enrichment in unavoidable case from the viewpoint of the resistance to nuclear proliferation in November, 1977. This policy is naturally applied to Japan also. The export of highly enriched uranium will be permitted only when the President approves it after the technical and economical evaluations by the government. The Kyoto University high flux reactor has the features which are not seen in other research reactors, such as medical irradiation, and it is hard to attain the objectives of researches unless HEU is used. The application for the export of HEU was accepted in February, 1978. The nuclear characteristics of the KUHFR when medium or low enriched uranium is used, the criticality experiment in the KUCA using the uranium of medium enrichment, and the burning test on the uranium fuel plates of medium enrichment are described. The research project to lower the degree of enrichment in the fuel for research and test reactors is expected to be continued down to less than 20%. The MEU of 45% enrichment will be actually used in 1983. (Kako, I.)

  2. Solving a multi-objective manufacturing cell scheduling problem with the consideration of warehouses using a simulated annealing based procedure

    Directory of Open Access Journals (Sweden)

    Adrián A. Toncovich

    2019-01-01

    Full Text Available The competition manufacturing companies face has driven the development of novel and efficient methods that enhance the decision making process. In this work, a specific flow shop scheduling problem of practical interest in the industry is presented and formalized using a mathematical programming model. The problem considers a manufacturing system arranged as a work cell that takes into account the transport operations of raw material and final products between the manufacturing cell and warehouses. For solving this problem, we present a multiobjective metaheuristic strategy based on simulated annealing, the Pareto Archived Simulated Annealing (PASA. We tested this strategy on two kinds of benchmark problem sets proposed by the authors. The first group is composed by small-sized problems. On these tests, PASA was able to obtain optimal or near-optimal solutions in significantly short computing times. In order to complete the analysis, we compared these results to the exact Pareto front of the instances obtained with augmented ε-constraint method. Then, we also tested the algorithm in a set of larger problems to evaluate its performance in more extensive search spaces. We performed this assessment through an analysis of the hypervolume metric. Both sets of tests showed the competitiveness of the Pareto Archived Simulated Annealing to efficiently solve this problem and obtain good quality solutions while using reasonable computational resources.

  3. [Moderation-integrated-balance presupposition of Chinese medicine compound and pharmacological problems in traditional Chinese drug research].

    Science.gov (United States)

    Zhao, Jun-Ning

    2017-03-01

    The moderation-integrated-balance presupposition (MIBP) of Chinese medicine compound was first proposed in this paper based on the review of function characteristics and action principles of Chinese medicine compound. Furthermore, the pharmacological problems of traditional Chinese drug research were discussed in details. The results were of important value in accelerating the transformation of traditional Chinese medicine compound, and constructing the new drug innovation and review system for traditional Chinese medicine. Copyright© by the Chinese Pharmaceutical Association.

  4. The Synergy of applying virtual collaboration tools and problem-based approach for development of knowledge sharing skills : empirical research

    OpenAIRE

    Schoop, Eric; Kriaučiūnienė, Roma; Brundzaitė, Rasa

    2004-01-01

    This article analyses the needs and possibilities to educate new type of virtual collaboration skills for the university students, who are currently studying in business and information systems area. We investigate the possibility to incorporate problem-based group learning and computer supported tools into university curricula. The empirical research results are presented, which summarize experiences of using the virtual collaborative learning (VCL) environment, provided by Business informat...

  5. Revisiting Employee Assistance Programs and Substance Use Problems in the Workplace: Key Issues and a Research Agenda

    OpenAIRE

    Levy Merrick, Elizabeth S.; Volpe-Vartanian, Joanna; Horgan, Constance M.; McCann, Bernard

    2007-01-01

    This column describes employee assistance program (EAPs) and identifies key issues for contemporary EAPs. These programs began as occupational alcohol programs and have evolved into more comprehensive resources. To better understand contemporary EAPs, the authors suggest a research agenda at includes descriptive studies to provide an up-to-date picture of services; investigations of how contemporary EAPs address substance use problems, including management consultation for early identificatio...

  6. The waste management at research laboratories - problems and solutions; Gestao de rejeitos radioativos em laboratorios de pesquisa - problemas e solucoes

    Energy Technology Data Exchange (ETDEWEB)

    Dellamano, Jose Claudio; Vicente, Roberto, E-mail: jcdellam@ipen.b, E-mail: rvicente@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Gerencia de Rejeitos Radioativos

    2011-10-26

    The radioactive management in radioactive installations must be planned and controlled. However, in the case of research laboratories, that management is compromised due to the common use of materials and installations, the lack of trained personnel and the nonexistence of clear and objective orientations by the regulator organism. Such failures cause an increasing of generated radioactive wastes and the imprecision or nonexistence of record of radioactive substances, occasioning a financial wastage, and the cancelling of licences for use of radioactive substances. This paper discusses and proposes solutions for the problems found at radioactive waste management in research laboratories

  7. DIGITAL HUMANISTIC PEDAGOGY: RELEVANT PROBLEMS OF SCIENTIFIC RESEARCH IN THE FIELD OF USING ICT IN EDUCATION

    Directory of Open Access Journals (Sweden)

    Valeriy Yu. Bykov

    2016-07-01

    Full Text Available In the article theoretical and methodological principles of digital humanistic pedagogy – the science about the laws of creating a positive integrated educational reality as a result of the convergence of physical and virtual (created using ICT training spaces (environments are determined. Based on the use of modern ICT learning activity (formal, nonformal and informal is at the intersection of two worlds: the real and the virtual. Methodology and research methods of classical pedagogy require review and improvement in the context of current realities of the educational process, needs and interests of all its subjects. The development of digital humanities in the international educational space is analyzed; the content of the new field of pedagogical knowledge as part of digital humanistic is outlined; research methods and directions of current scientific research are defined.

  8. Construction of anthropological knowledge and ethnographic co-research. Problems and challenges

    Directory of Open Access Journals (Sweden)

    Elena L. Achilli

    2017-09-01

    Full Text Available Discussing anthropological knowledge construction processes entails reflecting upon different connected dimensions. Epistemological and theoretical-methodological  positionings with different political consequences are intertwined. In addition, institutional conditions and the socio-historical context in which certain local and global disciplinary trends are inscribed must be taken into account. This paper looks into the processes of socio-anthropological research I have participated in over the last decades with schools, teachers, teacher unions, indigenous peoples and groups in conditions of structural poverty. I will particularly focus on the modalities of ethnographic co-research that we have implemented in several projects. I will attempt to show some of the theoretical-methodological potentialities that ethnography contributes to group/collective processes of research as well as limits in its development. Finally, I will mention some of the contemporary challenges anthropological knowledge faces in present Latin America.

  9. An overview on ethical considerations in stem cell research in Iran and ethical recommendations: A review

    Science.gov (United States)

    Farajkhoda, Tahmineh

    2017-01-01

    Conducting research on the stem cell lines might bring some worthy good to public. Human Stem Cells (hSCs) research has provided opportunities for scientific progresses and new therapies, but some complex ethical matters should be noticed to ensure that stem cell research is carried out in an ethically appropriate manner. The aim of this review article is to discuss the importance of stem cell research, code of ethics for stem cell research in Iran and ethical recommendation. Generation of stem cells for research from human embryo or adult stem cells, saving, maintenance and using of them are the main ethical, legal and jurisprudence concerns in Iran. Concerns regarding human reproduction or human cloning, breach of human dignity, genetic manipulation and probability of tumorogenisity are observed in adult/somatic stem cells. Destruction of embryo to generate stem cell is an important matter in Iran. In this regards, obtaining stem cell from donated frozen embryos through infertility treatment that would be discarded is an acceptable solution in Iran for generation of embryo for research. Ethical, legal, and jurisprudence strategies for using adult/somatic stem cells are determination of ownership of stem cells, trade prohibition of human body, supervision on bio banks and information of Oversight Committee on Stem Cell Research. Recommendations to handle ethical issues for conducting stem cell research are well-designed studies, compliance codes of ethics in biomedical research (specifically codes of ethics on stem cell research, codes of ethics on clinical trials studies and codes of ethics on animals studies), appropriate collaboration with ethics committees and respecting of rights of participants (including both of human and animal rights) in research. In addition, there is a necessity for extending global networks of bioethics for strengthening communications within organizations at both the regional and international level, strengthening legislation systems

  10. An overview on ethical considerations in stem cell research in Iran and ethical recommendations: A review

    Directory of Open Access Journals (Sweden)

    Tahmineh Farajkhoda

    2017-08-01

    Full Text Available Conducting research on the stem cell lines might bring some worthy good to public. Human Stem Cells (hSCs research has provided opportunities for scientific progresses and new therapies, but some complex ethical matters should be noticed to ensure that stem cell research is carried out in an ethically appropriate manner. The aim of this review article is to discuss the importance of stem cell research, code of ethics for stem cell research in Iran and ethical recommendation. Generation of stem cells for research from human embryo or adult stem cells, saving, maintenance and using of them are the main ethical, legal and jurisprudence concerns in Iran. Concerns regarding human reproduction or human cloning, breach of human dignity, genetic manipulation and probability of tumorogenisity are observed in adult/somatic stem cells. Destruction of embryo to generate stem cell is an important matter in Iran. In this regards, obtaining stem cell from donated frozen embryos through infertility treatment that would be discarded is an acceptable solution in Iran for generation of embryo for research. Ethical, legal, and jurisprudence strategies for using adult/somatic stem cells are determination of ownership of stem cells, trade prohibition of human body, supervision on bio banks and information of Oversight Committee on Stem Cell Research. Recommendations to handle ethical issues for conducting stem cell research are well-designed studies, compliance codes of ethics in biomedical research (specifically codes of ethics on stem cell research, codes of ethics on clinical trials studies and codes of ethics on animals studies, appropriate collaboration with ethics committees and respecting of rights of participants (including both of human and animal rights in research. In addition, there is a necessity for extending global networks of bioethics for strengthening communications within organizations at both the regional and international level, strengthening

  11. An overview on ethical considerations in stem cell research in Iran and ethical recommendations: A review.

    Science.gov (United States)

    Farajkhoda, Tahmineh

    2017-02-01

    Conducting research on the stem cell lines might bring some worthy good to public. Human Stem Cells (hSCs) research has provided opportunities for scientific progresses and new therapies, but some complex ethical matters should be noticed to ensure that stem cell research is carried out in an ethically appropriate manner. The aim of this review article is to discuss the importance of stem cell research, code of ethics for stem cell research in Iran and ethical recommendation. Generation of stem cells for research from human embryo or adult stem cells, saving, maintenance and using of them are the main ethical, legal and jurisprudence concerns in Iran. Concerns regarding human reproduction or human cloning, breach of human dignity, genetic manipulation and probability of tumorogenisity are observed in adult/somatic stem cells. Destruction of embryo to generate stem cell is an important matter in Iran. In this regards, obtaining stem cell from donated frozen embryos through infertility treatment that would be discarded is an acceptable solution in Iran for generation of embryo for research. Ethical, legal, and jurisprudence strategies for using adult/somatic stem cells are determination of ownership of stem cells, trade prohibition of human body, supervision on bio banks and information of Oversight Committee on Stem Cell Research. Recommendations to handle ethical issues for conducting stem cell research are well-designed studies, compliance codes of ethics in biomedical research (specifically codes of ethics on stem cell research, codes of ethics on clinical trials studies and codes of ethics on animals studies), appropriate collaboration with ethics committees and respecting of rights of participants (including both of human and animal rights) in research. In addition, there is a necessity for extending global networks of bioethics for strengthening communications within organizations at both the regional and international level, strengthening legislation systems

  12. Where to remove radioactive waste? Perspective for a problem-oriented sociological repository research

    International Nuclear Information System (INIS)

    Hocke, P.; Grunwald, A.

    2006-01-01

    The search for a final disposal site for high-level nuclear waste in Germany is to characterize as an enduring and politicised conflict causing a blocked process of decision making. A social science based research on final disposals, reflecting this stalemate situation in Germany, did not take place since the middle of the 1980s. This book persues three aims, it analyses the conflict situation in an historical and a systematic view, it discusses the new decision- and participation procedures and it formulates a socio-scientific research perspective on waste disposal. Th volume directs to political decision makers, representants from industry and economy, scientists and actors from the citizen sector. (GL)

  13. Research and technology strategy to help overcome the environmental problems in relation to transport

    International Nuclear Information System (INIS)

    Ferrary, C.

    1992-03-01

    This report considers local pollution issues, i.e. emissions which have an impact on the quality of water, air and soil with local and regional (e.g. acid deposition) significance. The following technology clusters: traffic control, modal transfer and fleet management are also examined and recommendations are made for a Community Research and Technology Development strategy

  14. No Randomization? No Problem: Experimental Control and Random Assignment in Single Case Research

    Science.gov (United States)

    Ledford, Jennifer R.

    2018-01-01

    Randomization of large number of participants to different treatment groups is often not a feasible or preferable way to answer questions of immediate interest to professional practice. Single case designs (SCDs) are a class of research designs that are experimental in nature but require only a few participants, all of whom receive the…

  15. Research shows 'poppers' use in connected with infection among MSM. Little is done to address problem.

    Science.gov (United States)

    2004-06-01

    Researchers and experts on the use of inhaled nitrates among men who have sex with men (MSM) say clinicians, public health officials, and AIDS groups are ignoring the impact of poppers, a popular party inhalant, on HIV risk behaviors and even seroconversion.

  16. Constructing and Reconstructing the "Rural School Problem": A Century of Rural Education Research

    Science.gov (United States)

    Biddle, Catharine; Azano, Amy Price

    2016-01-01

    This chapter examines 100 years of rural education research in the context of the demographic, migratory, economic, and social changes that have affected rural America in the past century. The authors conducted a systematic review of the literature on rural teacher recruitment, retention, and training as a case study to examine the constancy and…

  17. Internet-Mediated Technologies and Mixed Methods Research: Problems and Prospects

    Science.gov (United States)

    Hesse-Biber, Sharlene; Griffin, Amy J.

    2013-01-01

    This article provides an examination of a range of mixed methods research projects that employ Internet-mediated technologies (IMT) for data collection. Using a case study approach, this article allows for the uncovering of a process by which IMT are used as a data collection medium in mixed methods praxis. Under the theoretical position of medium…

  18. Somatic Cells Become Cancer’s “Starter Dough” | Center for Cancer Research

    Science.gov (United States)

    Cancer stem cells (CSCs) is a term that sparks animated differences of opinions among researchers in the oncology community.  Much of the disagreement comes from the difficulty involved in isolating these cells and manipulating them ex vivo. When putative CSCs are isolated from clinical samples, researchers are unable to retrospectively identify the cell type that suffered the

  19. 75 FR 8085 - National Institutes of Health Guidelines for Human Stem Cell Research

    Science.gov (United States)

    2010-02-23

    ... Health Guidelines for Human Stem Cell Research SUMMARY: The National Institutes of Health (NIH) is requesting public comment on a revision to the definition of human embryonic stem cells (hESCs) in the ``National Institutes of Health Guidelines for Human Stem Cell Research'' (Guidelines). On July 7, 2009, NIH...

  20. 75 FR 13137 - National Institutes of Health Guidelines for Human Stem Cell Research

    Science.gov (United States)

    2010-03-18

    ... Health Guidelines for Human Stem Cell Research SUMMARY: The National Institutes of Health (NIH) is extending the public comment period on a revision to the definition of human embryonic stem cells (hESCs) in the ``National Institutes of Health Guidelines for Human Stem Cell Research'' (Guidelines). Due to a...

  1. Twenty third scientific conference on research-scientific problems of constructing mine buildings and metallurgical plants

    Energy Technology Data Exchange (ETDEWEB)

    Swiadrowski, W

    1978-01-01

    Annual conference was held in Krynica from 16-23 September 1977. One hundred and nineteen papers were delivered, of these 24 papers were on mine buildings. It was noted that damage caused by underground coal mining is prevalent and characterized by a tendency to increase. In the middle of the 1970s damages paid by mines (mainly by coal mines) reached 5 billion zlotys yearly. Damages which were not compensated, and social cost of mining damages are not included in the calculation. The following problems were discussed: interaction between foundations of buildings with ground in areas affected by deformations; influnce of underground coal mining on properties of soil; improving construction of large industrial plants located on grounds characterized by surface deformations; influence of underground coal mining on deformations of walls of sedimentation tanks; complex utilization of mined deposits in the Upper Silesian basin, Rybnik basin and in the Lublin black coal basin (coal and other minerals). (In Polish)

  2. Twenty years of embryonic stem cell research in farm animals

    Science.gov (United States)

    Notable distinctions between an embryonic stem cell (ESC) and somatic cell are that the ESC can maintain an undifferentiated state indefinitely, self renew, and is pluripotent, meaning that the ESC can potentially generate cells representing all the three primordial germ layers and contribute to the...

  3. The fuel element of the first charge for EL 4; presentation, main problems arising in the research, production problems; L'element combustible du 1. jeu de EL 4; presentation, problemes essentiels poses par l'etude, problemes de fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Ringot, C; Bailly, H; Bujas, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    The fuel element making up the first charge for EL-4 is made of slightly enriched uranium oxide canned in stainless steel. This fuel element makes it possible to operate the reactor in the safest conditions awaiting the development of the fuel which will be finally adopted; this will have a low absorption can: beryllium, or a zirconium copper alloy. The 500 mm assembly is made up of 19 small rods placed on 3 rings, inside a graphite jacket. The solution adopted was a solution using completely independent small rods. This report deals with possible problems resulting from their study and production. (authors) [French] L'element combustible du 1er jeu EL-4 est un element combustible a oxyde d'uranium legerement enrichi gaine d'acier inoxydable. C'est un element combustible permettant de faire fonctionner le reacteur EL 4 dans des conditions aussi sures que possible avant de mettre au point le combustible definitif qui sera a gaine peu absorbante: beryllium, ou alliage zirconium-cuivre. L'assemblage de longueur 500 mm est constitue de 19 crayons places sur 3 couronnes, a l'interieur d'une chemise de graphite. La solution adoptee a ete une solution a crayons independants les uns des autres. Ce rapport traite des problemes eventuels poses par leur etude et leur fabrication. (auteurs)

  4. Health-related quality of life, cognitive functioning and behaviour problems in children with Langerhans cell histiocytosis

    NARCIS (Netherlands)

    Vrijmoet-Wiersma, C. M. Jantien; Kooloos, Vicky M.; Koopman, Hendrik M.; Kolk, Annemarie M.; van der Laan, Ingrid; Grootenhuis, Martha A.; Egeler, R. Maarten

    2009-01-01

    BACKGROUND: This study was designed to evaluate generic and disease-specific health-related quality of life (HRQoL), cognitive functioning and behaviour problems of children with Langerhans Cell Histiocytosis (LCH). Furthermore, we investigated which medical determinants and social demographic

  5. Aquatics Systems Branch: transdisciplinary research to address water-related environmental problems

    Science.gov (United States)

    Dong, Quan; Walters, Katie D.

    2015-01-01

    The Aquatic Systems Branch at the Fort Collins Science Center is a group of scientists dedicated to advancing interdisciplinary science and providing science support to solve water-related environmental issues. Natural resource managers have an increasing need for scientific information and stakeholders face enormous challenges of increasing and competing demands for water. Our scientists are leaders in ecological flows, riparian ecology, hydroscape ecology, ecosystem management, and contaminant biology. The Aquatic Systems Branch employs and develops state-of-the-science approaches in field investigations, laboratory experiments, remote sensing, simulation and predictive modeling, and decision support tools. We use the aquatic experimental laboratory, the greenhouse, the botanical garden and other advanced facilities to conduct unique research. Our scientists pursue research on the ground, in the rivers, and in the skies, generating and testing hypotheses and collecting quantitative information to support planning and design in natural resource management and aquatic restoration.

  6. Millisecond precision psychological research in a world of commodity computers: new hardware, new problems?

    Science.gov (United States)

    Plant, Richard R; Turner, Garry

    2009-08-01

    Since the publication of Plant, Hammond, and Turner (2004), which highlighted a pressing need for researchers to pay more attention to sources of error in computer-based experiments, the landscape has undoubtedly changed, but not necessarily for the better. Readily available hardware has improved in terms of raw speed; multi core processors abound; graphics cards now have hundreds of megabytes of RAM; main memory is measured in gigabytes; drive space is measured in terabytes; ever larger thin film transistor displays capable of single-digit response times, together with newer Digital Light Processing multimedia projectors, enable much greater graphic complexity; and new 64-bit operating systems, such as Microsoft Vista, are now commonplace. However, have millisecond-accurate presentation and response timing improved, and will they ever be available in commodity computers and peripherals? In the present article, we used a Black Box ToolKit to measure the variability in timing characteristics of hardware used commonly in psychological research.

  7. Research and technology strategy to help overcome the environmental problems in relation to transport

    International Nuclear Information System (INIS)

    Gwilliam, K.M.; Geerlings, H.

    1992-04-01

    This report has been prepared for the Strategic Analysis in Science and Technology Unit (SAST) of the Directorate-General for Science, Research and Development of the Commission of the European Communities. The background of the project to which this report contributes is a recognition of the growing impact of transportation on the environment, both as a function of growth in trade and as a leisure activity. The project is directed towards the elucidation of the many interactions between technology, transport and environment, in order to provide the Commission with (a) recommendations on the priorities for Community research and development in transport technology and other related areas of technology, and (b) an understanding of the implications of technological change on policy options, within the Community with regard to transport and environment and other related areas, such as energy and regional planning

  8. Problems studied within the state research project New Methods of Nondestructive Materials Testing Using Ionizing Radiation

    International Nuclear Information System (INIS)

    Mysak, F.; Strba, J.

    1979-01-01

    A state research project is described divided into ten subprojects, viz.: New trends of ionizing radiation detection using television technology in nondestructive testing; the application of accelerators for thick-walled product testing; the atlas of butt welds of medium thicknesses; the application of radioanalytical methods in testing the wear of gearboxes and other components of instrument parts; multielemental analyses of combustion engine wear using radionuclides; the application of radioisotope methods in research into wear of antifriction bearings of trucks and railway cars; the application of radionuclides in assessing corrosion resistance of steels and corrosion protection systems; the application of radionuclide methods in improving the quality of high-grade steel production; the selection and testing of radionuclide instruments for building production control, intermediate and acceptance checks; and radioisotope methods for building machine and equipment control. (M.S.)

  9. The problem of measurement model misspecification in behavioral and organizational research and some recommended solutions.

    Science.gov (United States)

    MacKenzie, Scott B; Podsakoff, Philip M; Jarvis, Cheryl Burke

    2005-07-01

    The purpose of this study was to review the distinction between formative- and reflective-indicator measurement models, articulate a set of criteria for deciding whether measures are formative or reflective, illustrate some commonly researched constructs that have formative indicators, empirically test the effects of measurement model misspecification using a Monte Carlo simulation, and recommend new scale development procedures for latent constructs with formative indicators. Results of the Monte Carlo simulation indicated that measurement model misspecification can inflate unstandardized structural parameter estimates by as much as 400% or deflate them by as much as 80% and lead to Type I or Type II errors of inference, depending on whether the exogenous or the endogenous latent construct is misspecified. Implications of this research are discussed. Copyright 2005 APA, all rights reserved.

  10. Some radiation protection problems in a cancer hospital and associated research institute

    International Nuclear Information System (INIS)

    Trott, N.G.; Anderson, W.; Davis, R.P.; Carden, D.M.

    1980-01-01

    Experience gained at the Royal Marsden Hospital and Institute of Cancer Research has shown that with attention to the design of facilities and procedures and an active personnel monitoring policy, relatively large scale radiation commitments can proceed with individual whole body doses to staff being held well below 15 mSv/annum. In spite of detailed attention to control of radiation work, traumatic radiation incidents may still occur. (H.K.)

  11. Business research as an educational problem-solving heuristic - the case of Porter's diamond

    OpenAIRE

    O'Connell, Laurence; Clancy, Paula; Van Egeraat, Chris

    1999-01-01

    Explores the link between research practice and business education. The work of Michael Porter has a long association with the field of marketing. Focuses on the Porter's diamond model of national competitive advantage (1990). Draws on recent experiences from an empirical investigation into sources of competitive advantage and suggests that the model is useful as a conceptual framework for practitioner-orientated discourse concerning developmental issues. Outlines the process o...

  12. Final results of the fifth three-dimensional dynamic Atomic Energy Research benchmark problem calculations

    International Nuclear Information System (INIS)

    Hadek, J.

    1999-01-01

    The paper gives a brief survey of the fifth three-dimensional dynamic Atomic Energy Research benchmark calculation results received with the code DYN3D/ATHLET at NRI Rez. This benchmark was defined at the seventh Atomic Energy Research Symposium (Hoernitz near Zittau, 1997). Its initiating event is a symmetrical break of the main steam header at the end of the first fuel cycle and hot shutdown conditions with one stuck out control rod group. The calculations were performed with the externally coupled codes ATHLET Mod.1.1 Cycle C and DYN3DH1.1/M3. The standard WWER-440/213 input deck of ATHLET code was adopted for benchmark purposes and for coupling with the code DYN3D. The first part of paper contains a brief characteristics of NPP input deck and reactor core model. The second part shows the time dependencies of important global and local parameters. In comparison with the results published at the eighth Atomic Energy Research Symposium (Bystrice nad Pernstejnem, 1998), the results published in this paper are based on improved ATHLET descriptions of control and safety systems. (Author)

  13. Maternal smoking during pregnancy and offspring conduct problems: Evidence from three independent genetically-sensitive research designs

    Science.gov (United States)

    Gaysina, Darya; Fergusson, David M.; Leve, Leslie D.; Horwood, John; Reiss, David; Shaw, Daniel S.; Elam, Kit K.; Natsuaki, Misaki N.; Neiderhiser, Jenae M.; Harold, Gordon T.

    2013-01-01

    Context A number of studies report an association between maternal smoking during pregnancy and offspring conduct disorder. However, past research evidences difficulty disaggregating prenatal environmental from genetic and postnatal environmental influences. Objective To examine the relationship between maternal smoking during pregnancy and offspring conduct problems among children reared by genetically-related and genetically-unrelated mothers. Design, Setting and Participants Three studies employing distinct but complementary research designs were utilized: The Christchurch Health and Development Study (a longitudinal cohort study that includes biological and adopted children), the Early Growth and Development Study (a longitudinal adoption at birth study), and the Cardiff IVF Study (genetically-related and -unrelated families; an adoption at conception study). Maternal smoking during pregnancy was measured as the average number of cigarettes/day (0, 1–9 or 10+) smoked during pregnancy. A number of possible covariates (child gender, ethnicity, birth weight, breast feeding, maternal age at birth, maternal education, family SES, family breakdown, placement age, and parenting practices) were controlled in the analyses. Main Outcome Measure Child conduct problems (age 4–10 years) reported by parents and/or teachers using the Rutter and Conners behaviour scales, the Child Behavior Checklist and Children's Behavior Questionnaire, and the Strengths and Difficulties Questionnaire. Results A significant association between maternal smoking during pregnancy and child conduct problems was observed among children reared by genetically-related and genetically-unrelated mothers. Results from a meta-analysis affirmed this pattern of findings across pooled study samples. Conclusions Findings across the three studies using a complement of genetically-sensitive research designs suggest smoking during pregnancy is a prenatal risk factor for offspring conduct problems, when

  14. Co-occurring substance abuse and mental health problems among homeless persons: Suggestions for research and practice

    Science.gov (United States)

    Polcin, Douglas L.

    2016-01-01

    Abstract Communities throughout the U.S. are struggling to find solutions for serious and persistent homelessness. Alcohol and drug problems can be causes and consequences of homelessness, as well as co-occurring problems that complicate efforts to succeed in finding stable housing. Two prominent service models exist, one known as “Housing First” takes a harm reduction approach and the other known as the “linear” model typically supports a goal of abstinence from alcohol and drugs. Despite their popularity, the research supporting these models suffers from methodological problems and inconsistent findings. One purpose of this paper is to describe systematic reviews of the homelessness services literature, which illustrate weaknesses in research designs and inconsistent conclusions about the effectiveness of current models. Problems among some of the seminal studies on homelessness include poorly defined inclusion and exclusion criteria, inadequate measures of alcohol and drug use, unspecified or poorly implemented comparison conditions, and lack of procedures documenting adherence to service models. Several recent papers have suggested broader based approaches for homeless services that integrate alternatives and respond better to consumer needs. Practical considerations for implementing a broader system of services are described and peer-managed recovery homes are presented as examples of services that address some of the gaps in current approaches. Three issues are identified that need more attention from researchers: (1) improving upon the methodological limitations in current studies, (2) assessing the impact of broader based, integrated services on outcome, and (3) assessing approaches to the service needs of homeless persons involved in the criminal justice system. PMID:27092027

  15. Hydrogen and fuel cell research: Institute for Integrated Energy Systems (IESVic)

    International Nuclear Information System (INIS)

    Pitt, L.

    2006-01-01

    Vision: IESVic's mission is to chart feasible paths to sustainable energy. Current research areas of investigation: 1. Energy system analysis 2. Computational fuel cell engineering; Fuel cell parameter measurement; Microscale fuel cells 3. Hydrogen dispersion studies for safety codes 4. Active magnetic refrigeration for hydrogen liquifaction and heat transfer in metal hydrides 5. Hydrogen and fuel cell system integration (author)

  16. Methods in Molecular Biology: Germline Stem Cells | Center for Cancer Research

    Science.gov (United States)

    The protocols in Germline Stem Cells are intended to present selected genetic, molecular, and cellular techniques used in germline stem cell research. The book is divided into two parts. Part I covers germline stem cell identification and regulation in model organisms. Part II covers current techniques used in in vitro culture and applications of germline stem cells.

  17. Abortion research: attitudes, sexual behavior, and problems in a community college population.

    Science.gov (United States)

    Bryan, J W; Freed, F W

    1993-02-01

    150 (80 females and 70 males) community college students were surveyed regarding their attitudes toward abortion, their sexual behavior, and their problems. The profile of the students was Caucasian (95%), young (18-24 years = 87%), single (87%), middle and lower middle class, and Catholic (70%). 82% supported abortion choice, 86% had engaged in premarital sex, 70% used contraception, and 26% had premarital pregnancies. The hard reasons for abortion (rape, the woman's life, is endangered, and the fetus is defective) received high support. The soft reasons (the family cannot afford more children or the woman does not want to marry the man) received lower support. The students were divided into 3 groups of 50 students based on the number of abortion reasons they supported out of 43 reasons. The low-group that accepted 0-10 reasons was called anti-abortion. 50% of them still believed a woman has a right to an abortion vs. 97% of the pro-abortion students. The students reported many problems in their families: alcoholic home (39%), loss of a parent through death, divorce, or separation (33%), victims of severe corporal punishment (31%), one or more family members physically abused (20%), and deprived of parental affection while growing up (20%). When the anti-abortion females (N=30) were compared with the pro-abortion females (N=50), they reported significantly (p.01) more hospitalization, a greater number of physical handicaps, and more shyness (p.1). When the anti-abortion males (N=20) were compared with the pro-abortion males (N=50), they reported significantly more obesity and agoraphobia (p.05) and more convictions for a crime (p.1). Comparison of women who had abortion (N=13) with the women who had their baby (N=8) indicated that the latter reported significantly (p.01) more battering by their boyfriend or husband, significantly (p.05) more battering in their family of origin and childhood sexual abuse, and a greater tendency (p.1) to have been raped.

  18. Operating experience and radiation protection problems in the working of the radio-metallurgy hot cell facilities at BARC

    International Nuclear Information System (INIS)

    Janardhanan, S.; Watamwar, S.B.; Mehta, S.K.; Pillai, P.M.B.; John, Jacob; Kutty, K.N.

    1977-01-01

    The Bhabha Atomic Research Centre at Bombay has six hot cell facilities for radiometallurgical investigations of irradiated/failed fuel elements. The hot cell facilities have been provided with certain built-in safety features, a ventilation system, radiation monitoring instruments for various purposes, a centralised air monitoring system and a central panel for display of various alarms. Procedures adopted for radiation protection and contamination control include : (1) radiation leak test for cells and filter efficiency evaluation before cell activation, (2) practices to be followed by frog suit personnel while working in hot cell areas, (3) receipt and handling of irradiated fuel elements, (4) cell filter change operation, (5) checks on high level drains and (6) effluent discharge and waste shipments. Operating experience in the working of these facilities along with radiation accident incidents is described. Data regarding release of activity during normal cell operations, dose rates during various metallurgical operations and personnel exposures are presented. (M.G.B.)

  19. Low-cost approaches to problem-driven hydrologic research: The case of Arkavathy watershed, India.

    Science.gov (United States)

    Srinivasan, V.; Ballukraya, P. N.; Jeremiah, K.; R, A.

    2014-12-01

    Groundwater depletion is a major problem in the Arkavathy Basin and it is the probable cause of declining flows in the Arkavathy River. However, investigating groundwater trends and groundwater-surface water linkages is extremely challenging in a data-scarce environment where basins are largely ungauged so there is very little historical data; often the data are missing, flawed or biased. Moreover, hard-rock aquifer data are very difficult to interpret. In the absence of reliable data, establishing a trend let alone the causal linkages is a severe challenge. We used a combination of low-cost, participatory, satellite based and conventional data collection methods to maximize spatial and temporal coverage of data. For instance, long-term groundwater trends are biased because only a few dug wells with non-representative geological conditions still have water - the vast majority of the monitoring wells drilled in the 1970s and 1980s have dried up. Instead, we relied on "barefoot hydrology" techniques. By conducting a comprehensive well census, engaging farmers in participatory groundwater monitoring and using locally available commercial borewell scanning techniques we have been able to better establish groundwater trends and spatial patterns.

  20. Vignette Research on Messy and Confusing Problems in Primary Mental Healthcare

    Directory of Open Access Journals (Sweden)

    E. H. (Dineke Smit

    2017-05-01

    Full Text Available The average primary care psychologist feels an ever-widening gap between objective, measurable reality as described and the complex and dynamic reality they experience. To obtain a better understanding of this complex dynamic reality, we conducted an exploratory mixed-method study of primary care psychologists. We asked our participants to write vignettes about messy and confusing problems in the complex context of mental healthcare. We then examined the data in portions, exposed the patterns in the data, and subsequently analysed all in conjunction. The 113 vignettes showed experiences of psychologists dealing not only with the patient, but also with the family of the patient and/or employers, working together with other healthcare professionals, struggling with dilemmas and having mixed feelings. However, using the Cynafin Framework, 36% of the vignettes were still rated as simple. Was it because those vignettes contained fewer words (p = .006? Or because it is difficult to grasp complexity when cause and effect are intertwined with emotions, norms and values? In the discussion, we suggest examining a complex dynamic system in terms of both the consistency of its various elements and the dynamics of the system. We also discuss how to optimize the system’s adaptive self-organizing ability and how to challenge ourselves to invent negative feedback loops that can keep the complex system in equilibrium.

  1. CO2 Problems and waste recycling. Research at the Institute of ferrous metallurgy

    OpenAIRE

    Gudenau, H. W.; Senk, D.; Babich, A.; Fröhling, C.; Kueon, O. S.; Wang, S.; Wieting, X.

    2005-01-01

    In a short introduction tests and calculations about CO2-ice-blocs in the deep sea, use of CO2 for underground-coal-gasification and tertiary processes to increase oil-production by C02-flooding are shown. New activities are presented e.g. CO2-injection into EAF combined with injection of coal, coke or directreduction-fines. After research of injection of coals, fine ores or dust into blast furnaces and other shaft furnaces ...

  2. Research reactors. Problems of fuel element enrichment reduction. Deliberations and comments

    International Nuclear Information System (INIS)

    1978-10-01

    This paper summarises the main data from the major research reactors in the Federal Republic of Germany utilising highly enriched uranium (HEU) and presently available fuel technology for their fuel elements. The required modification for an adaption of the fabrication to lower enriched fuel are considered as well as the consequences on reactor performance operation and licensing. On the basis of past experience with reactor modifications a rough estimate of 82 months is given for the conversion of a reactor to a modified type of fuel and of 70 months for a fuel test program. The conclusions reflect the own calculations and data from other papers submitted to INFCE-WG 8C

  3. Fusion power: massive research program aims at formidable problems, almost limitless potential

    International Nuclear Information System (INIS)

    Dingee, D.A.

    1979-01-01

    This article surveys extensively fusion development under the following topics: US research directions; inertial confinement fusion; foreign fusion efforts; fusion issues; fusion applications; and arguments for fusion development. Dr. Dingee points out that, despite persuasive arguments for development, fusion has as yet attracted no substantial constituency; and that winning greater support for fusion may thus require a considerable technical breakthrough (namely, proof of scientific feasibility or achievement of energy breakeven) - or a new focus on an energy source such as hybrids, which offer a nearer-term payoff than pure fusion. Dr. Dingee says the next major facility for magnetic confinement research (to be built in late 1980s) has not yet been selected, but will probably be an engineering test facility; there are similar plans for inertial confinement. Whichever type is chosen, the first experimental power reactor is scheduled for the first few years of the 2000's, this to be followed by commercial demonstration of fusion power in the 2010 to 2020 time frame. He points out, finally, that the complex technical and institutional issues are being considered in a climate in which the benefits of nuclear energy itself are being questioned; and that there is little doubt that future development is tied to overall decisions the nation will make regarding the value of nuclear energy

  4. Deconstructing facts and frames in energy research: Maxims for evaluating contentious problems

    International Nuclear Information System (INIS)

    Sovacool, Benjamin K.; Brown, Marilyn A.

    2015-01-01

    In this article, we argue that assumptions and values can play a combative, corrosive role in the generation of objective energy analysis. We then propose six maxims for energy analysts and researchers. Our maxim of information asks readers to keep up to date on trends in energy resources and technology. Our maxim of inclusivity asks readers to involve citizens and other public actors more in energy decisions. Our maxim of symmetry asks readers to keep their analysis of energy technologies centered always on both technology and society. Our maxim of reflexivity asks readers to be self-aware of one's assumptions. Our maxim of prudence asks readers to make energy decisions that are ethical or at least informed. Our maxim of agnosticism asks readers to look beyond a given energy technology to the services it provides and recognize that many systems can provide a desired service. We conclude that decisions in energy are justified by, if not predicated on, beliefs—beliefs which may or may not be supported by objective data, constantly blurring the line between fact, fiction, and frames. - Highlights: • Assumptions and values can play a combative, corrosive role in the generation of objective energy analysis. • Decisions in energy are justified by, if not predicated on, beliefs. • We propose six maxims for energy analysts and researcher.

  5. NATO Advanced Research Workshop on Earth Rotation : Solved and Unsolved Problems

    CERN Document Server

    1986-01-01

    The idea for organl.zl.ng an Advanced Research Workshop entirely devoted to the Earth rotation was born in 1983 when Professor Raymond Hide suggested this topic to the special NATO panel of global transport mechanism in the Geosciences. Such a specialized meeting did not take place since the GEOP research conference on the rotation of the Earth and polar motion which was held at the Ohio State University (USA) in 1973. In the last ten years, highly precise measurements of the Earth's rotation parameters and new global geophysical data have become available allowing major advance to be made in the under­ standing of the various irregularities affecting the Earth's rotation. The aim of the workshop was to bring together scientists who have made important contributions in this field during the last decade both at the observational and geophysical interpretation levels. The confe­ rence was divided into four main topics. The first session was dedicated to the definition, implementation and maintenance of the te...

  6. Problems of Research, Projects and Mechanisms for Their Implementation in Chelyabinsk City Agglomeration

    Science.gov (United States)

    Bolshakov, V. V.

    2017-11-01

    The article analyzes the research and design methods of urban agglomerations in the context of the Chelyabinsk agglomeration from the point of view of correctness, objectivity and consistency of the results obtained. The completed and approved project of the Chelyabinsk agglomeration is analysed to provide architectural and planning solutions for sustainable social and economic development according to the theories that have been formed to date. The possibility of effectuation and implementation of the approved project of the Chelyabinsk agglomeration taking in account existing specific natural, historical and socio-economic factors characteristic for the territory under consideration is examined. The authors draw the conclusions the project of the Chelyabinsk agglomeration has been developed in line with the town-planning solutions that do not reflect modern approaches based on the competitive advantages of territories and do not form a space providing transition to a modernized and innovative economy. Specific town-planning decisions have a weak justification and an undeveloped methodology for pre-project analysis and methodology for designing urban agglomerations because of absence of a full study of the phenomenon of urban agglomeration and processes occurring in it today. It is necessary to continue research in the field of development of the Chelyabinsk agglomeration with the use of a logical and objective methodology to analyze the territory and design which can lead to the formation of an urban-planning information model that reflects all the system processes and allows for predicting project solutions.

  7. Fuel Cells: Power System Option for Space Research

    Science.gov (United States)

    Shaneeth, M.; Mohanty, Surajeet

    2012-07-01

    Fuel Cells are direct energy conversion devices and, thereby, they deliver electrical energy at very high efficiency levels. Hydrogen and Oxygen gases are electrochemically processed, producing clean electric power with water as the only by product. A typical, Fuel Cell based power system involve a Electrochemical power converter, gas storage and management systems, thermal management systems and relevant control units. While there exists different types of Fuel cells, Proton Exchange Membrane (PEM) Fuel Cells are considered as the most suitable one for portable applications. Generally, Fuel Cells are considered as the primary power system option in space missions requiring high power ( > 5kW) and long durations and also where water is a consumable, such as manned missions. This is primarily due to the advantage that fuel cell based power systems offer, in terms of specific energy. Fuel cells have the potential to attain specific energy > 500Wh/kg, specific power >500W/kg, energy density > 400Whr/L and also power density > 200 W/L. This apart, a fuel cell system operate totally independent of sun light, whereas as battery based system is fully dependent on the same. This uniqueness provides added flexibility and capabilities to the missions and modularity for power system. High power requiring missions involving reusable launch vehicles, manned missions etc are expected to be richly benefited from this. Another potential application of Fuel Cell would be interplanetary exploration. Unpredictable and dusty atmospheres of heavenly bodies limits sun light significantly and there fuel cells of different types, eg, Bio-Fuel Cells, PEMFC, DMFCs would be able to work effectively. Manned or unmanned lunar out post would require continuous power even during extra long lunar nights and high power levels are expected. Regenerative Fuel Cells, a combination of Fuel Cells and Electrolysers, are identified as strong candidate. While application of Fuel Cells in high power

  8. Research of a problem of qualification validation and reskilling of migrants

    Directory of Open Access Journals (Sweden)

    V. A. Gerasimova

    2016-01-01

    Full Text Available In this article authors have analysed the questions connected with globalization of economic space and the arising problems of migration of able-bodied citizens. The need to assess the conformity of the received skills and to recognise migrants’ skills in an expanding labor markets and reducing low-skilled personnel was revealed. Authors examined the professional standards’ merits in force in the territory of Russia, and revealed their shortcomings. They have defined that questions of verification of migrants qualification depend on national peculiarities of the host country and system of preparation of professional shots. It was found out that in Europe learning results obtained by different methods are recognized after the introduction of the system of education competence approach. They studied models of different systems of training and retraining of specialists, employed in different countries, based on their personal characteristics and validation of prior learning outcomes. Authors have come to the conclusion that, taking into account the specifics of Russian companies and the differences in the education system in Russia is inappropriate to apply the existing models developed by the international community. They justify the need for the creation of information and computer support for the evaluation process of competence formation. It was expressed the view that the definition of basic competences in the construction of learning paths is need. The synthesis of elements of competence “Know” was performed as example of a description of the individual graph construction. The view was expressed, that in the learning course formation its payback must be taken into account, in this connection, the authors proposed the integrated discipline assessment criterion in a hierarchical structure. The integrated criterion unites three groups of indicators of a course: consumer value, its requirement and resource intensity.

  9. A POX on Renal Cancer Cells | Center for Cancer Research

    Science.gov (United States)

    Proline oxidase, or POX, is an enzyme responsible for metabolizing the amino acid proline. POX contributes to the regulation of cell death that occurs when cellular systems malfunction, a process called apoptosis. Previous studies have determined that levels of POX are reduced in several types of human cancer. Likewise, many cancer cells become resistant to apoptosis, suggesting a link between POX and cancer cell survival.

  10. Manufacturing/Cell Therapy Specialist | Center for Cancer Research

    Science.gov (United States)

    Within the Leidos Biomedical Research Inc.’s Clinical Research Directorate, the Clinical Monitoring Research Program (CMRP) provides high-quality comprehensive and strategic operational support to the high-profile domestic and international clinical research initiatives of the National Cancer Institute (NCI), National Institute of Allergy and Infectious Diseases (NIAID),

  11. Recommendations regarding problems of research policy relating to the establishment and operation of atomic power stations in Denmark

    Energy Technology Data Exchange (ETDEWEB)

    1976-01-01

    This report, which was submitted by the Danish Planning Council for Research to the Parliamentary Committee on Scientific Research, is based on reports from the DANISH Atomic Energy Commission. and on a sub-committee appointed by the Planning Council, as well as on the comments of the Danish Research Council on these reports. The Planning Council submit that: (1) the question of the introduction and scope of Danish utilization of atomic energy should be considered as a link in setting up a total plan for energy policy elucidating the possibilities in the energy field from both aspects of supply and demand, (2) that there is a continuous interaction between energy policy and research policy in the subject field, (3) that the total resources for energy research and development should be considerably increased, (4) that investigations into the economy of atomic power should be intensified, and (5) that investigations of possibilities for long-term storage of radioactive waste in Denmark should be speeded up. Further, the Planning Council points out the need for research in areas such as (a) wind and solar energy, (b) the environmental impact of utilizing atomic power in relation to that of utilizing other forms of power, (c) economic and social effects of different forms of energy supply, as well as the problems of siting, decision taking and public information and participation and finally, (d) the utilization of the energy raw materials found in Greenland.

  12. Recommendations regarding problems of research policy relating to the establishment and operation of atomic power stations in Denmark

    International Nuclear Information System (INIS)

    1976-01-01

    This report, which was submitted by the Danish Planning Council for Research to the Parliamentary Committee on Scientific Research, is based on reports from the DANISH Atomic Energy Commission. and on a sub-committee appointed by the Planning Council, as well as on the comments of the Danish Research Council on these reports. The Planning Council submit that: 1) the question of the introduction and scope of Danish utilization of atomic energy should be considered as a link in setting up a total plan for energy policy elucidating the possibilities in the energy field from both aspects of supply and demand, 2) that there is a continuous interaction between energy policy and research policy in the subject field 3) that the total resources for energy research and development should be considerably increased, 4) that investigations into the economy of atomic power should be intensified, and 5) that investigations of possibilities for long-term storage of radioactive waste in Denmark should be speeded up. Further, the Planning Council points out the need for research in areas such as a) wind and solar energy, b) the environmental impact of utilizing atomic power in relation to that of utilizing other forms of power, c) economic and social effects of different forms of energy supply, as well as the problems of siting, decision taking and public information and participation and finally, d) the utilization of the energy raw materials found in Greenland. (B.P.)

  13. Effects of Sonic Booms on Marine Mammals: Problem Review and Recommended Research

    Science.gov (United States)

    Bowles, Ann E.

    1996-01-01

    By flying the High-Speed Civil Transport (HSCT) exclusively over uninhabited areas and mo over water, human annoyance will be reduced to acceptable levels. However, this strategy will for HSCT proponents to contend with the potential effects of sonic booms on animals, particularly ma mammals. What follows is a summary of the environmental regulations that must be addressed, the scientific community's concerns about the potential effects of the HSCT, and recommendations fox research to address the most important concerns. The recommendations included herein are based both on existing scientific evidence and regulatory needs. One cannot over-emphasize the importance of obtaining the appropriate information prior to substantial public exposure. Recent controversies over other human-made acoustic sources in the ocean suggest that the HSCT will receive intense scrutiny. It seems certain that an Environmental Impact Statement (EIS) and Incidental Harassment Authorization (IHA) under the Marine Mammal Protection Act (MMPA) or its equivalent will be necessary.

  14. [German medicine of the age of romanticism (1797-1848) as research problem].

    Science.gov (United States)

    Płonka-Syroka, B

    1997-01-01

    In the period between 1797 and 1848, German medicine was considerably influenced by philosophy. It absorbed ideas deriving from neo-Platonism and vitalism, as well as the modern philosophy of nature (Naturphilosophie), especially the ideas of Schelling. The article presents the main tendencies in the German medicine of that period: the distinct character of German medical thought as compared to the rest of Europe, the deductive character of medical theories, the grounding of medical thought in non-materialist philosophy and its close ties with the Protestant religion. The author's aim is investigate how German medicine of the period evolved away from European standards set by the model of medicine as an empirical science, based on the inductive method of research. The article presents the state of German medicine of the first half of the nineteenth century against the background of socio-cultural factors and relates German medical theory of the period to the social awareness of that time.

  15. Johann Jakob Wettstein. New Sources, New Problems, and New Possibilities for Digital Research

    Directory of Open Access Journals (Sweden)

    Jan Krans

    2016-04-01

    Full Text Available Johann Jakob Wettstein (1683-1754 worked almost all his life toward the publication of his landmark 1751-52 edition of the Greek New Testament. In recent years, a large number of previously unknown sources on and by Wettstein has come to light, scattered over libraries in Europe, that provide new insights into his life and his New Testament project. This paper explores the diversity of these sources, their genres, their connections, their state of conservation and accessibility and the like. Starting from the idea that the collection offers an excellent opportunity for mapping a single scholar’s projects and international networks over time and space, it envisages a project that brings together this wealth of material. It asks what challenges and possibilities for international digital research the collection entails and formulates the desiderata concerning the necessary digital infrastructure and collaboration across traditional scholarly boundaries.

  16. Chemical and microbiological problems associated with research on the biodesulfurization of coal. A review

    Energy Technology Data Exchange (ETDEWEB)

    Olson, G J; Kelly, R M [National Institute of Standards and Technology, Gaithersburg, MD (USA). Polymer Division

    1991-04-01

    The study of microbial processes for the removal of organic and inorganic sulfur from coals is complicated by the lack of direct methods of measurement for organic sulfur content and the related incomplete understanding of the specific forms of organic sulfur in coal. In addition, the accessibility of specific chemical groups in the coal matrix to microorganisms and their enzymes is uncertain, raising questions about the nature and validity of model compound studies. Thus, interpretation of data from numerous efforts focussed on the microbial removal of inorganic and organic sulfur from coals remains controversial. The discussion here reviews recent developments in the chemical characterization of coal sulfur related to bioprocessing research and describes some recent efforts in involving sulfur transformation by hyperthermophilic archaebacteria. 26 refs., 4 figs., 1 tab.

  17. Prospects for Research Training Activities in the Context of the Problems of the Modern Practice of Primary School.

    Directory of Open Access Journals (Sweden)

    Guruzhapov V. A.

    2015-11-01

    Full Text Available The article describes the current problems of research training activities in terms of the requirements of the Federal state educational standard of primary education. The initial methodological basis for the formulation of the problems is the theory of developmental education by Davydov and his followers. The article raises the question of the possibility of using the ideas of Dewey and Maslow to develop research training activities. There is the analysis of such subjects as formulating and performing learning tasks as a way of mastering theoretical knowledge in «from abstract to particular» microcycle; the content of theoretical generalizations formed before training activities (naive scientific concepts; forms of assimilation into the collective training activities; forms of cooperation in teaching and project activities; the content and form of requirements for training activities. Possible practical use of the study results are described. This area provides a lot of topics for Master’s thesis in the “Cultural-Historical Psychology and Activity Approach in Education” research Master’s program

  18. Perspectives on research and development of microbial fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Ortega-Martinez, A.; Vazquez Larios, A.L.; Solorza-Feria, O.; Poggi Varaldo, H.M. [Centro de Investigacion y de Estudios Avanzados del IPN, Mexico D.F. (Mexico)]. E-mail: hectorpoggi2001@gmail.com; rareli@hotmail.com

    2009-09-15

    Microbial fuel cells (MFC), is an anoxic electrochemical bioreactor where bacteria grow in the absence of oxygen in a chamber containing an anode which it may be covered by a biofilm. Microorganisms anoxically oxidize the organic substrate and electrons generated are released to the anode. Released protons are transferred to the cathode. Natural or forced aeration of the cathode supplies the oxygen for the final reaction 2H{sup +} + 2e{sup -} + (1/2) O{sub 2} = H{sub 2}O. In this work, we present a critical review on MFC focused on subjects that are receiving a growing interest from the research and technological communities: (i) types of MFC, their relative advantages and disadvantages and ranges of application; (ii) development of biocathodes; (iii) enrichment procedures of microbial communities in MFC. Recent research shows that one-chamber fitted with cathode aerated by natural aeration, and other special types of high performance MFC, have displaced the historical two-chamber MFC. Recent studies showed that electrochemically active bacteria (EAB) can be successfully enriched in MFC. The cost and eventual poisoning of the platinum catalyst used at the cathode is a major limitation to MFC application and economic viability. Researchers have started working on the concept of biocathodes that would use bacteria instead of platinum as a biocatalyst. Microbial enrichment of inocula seeded to MFC may provide a way to enrich the consortium with EAB, thus substantially increasing the transfer of electrons to the anode. Bioaugmentation of consortia in MFC with strains EAB, could contribute to the same goal. [Spanish] Las celdas de combustible microbianas (CCM) son un biorrector anoxico donde las bacterias crecen en ausencia de oxigeno en una camara que contiene un anodo que puede cubrirse con una biopelicula. Los microorganismos oxidan onoxicamente el sustrato organico y los electrones generados se liberan al anodo. Los protones liberados se transfieren al catodo. La

  19. [Breakthrough in research on pluripotent stem cells and their application in medicine].

    Science.gov (United States)

    Valdimarsdóttir, Guðrún; Richter, Anne

    2015-12-01

    Embryonic stem cells are, as the name indicates, isolated from embryos. They are pluripotent cells which can be maintained undifferentiated or induced to differentiate into any cell type of the body. In 1998 the first isolation of human embryonic stem cells was successful and they became an interesting source for stem cell regenerative medicine. Only 8 years later pluripotent stem cells were generated by reprogramming somatic cells into induced pluripotent stem cells (iPSCs). This was a revolution in the way people thought of cell commitment during development. Since then, a lot of research has been done in understanding the molecular biology of pluripotent stem cells. iPSCs can be generated from somatic cells of a patient and therefore have the same genome. Hence, iPSCs have great potential application in medicine, as they can be utilized in disease modelling, drug screening and cell replacement therapy.

  20. RESEARCH OF PROBLEMS OF DESIGN OF COMPLEX TECHNICAL PROVIDING AND THE GENERALIZED MODEL OF THEIR DECISION

    Directory of Open Access Journals (Sweden)

    A. V. Skrypnikov

    2015-01-01

    Full Text Available Summary. In this work the general ideas of a method of V. I. Skurikhin taking into account the specified features develop and questions of the analysis and synthesis of a complex of technical means, with finishing them to the level suitable for use in engineering practice of design of information management systems are in more detail considered. In work the general system approach to the solution of questions of a choice of technical means of the information management system is created, the general technique of the sys tem analysis and synthesis of a complex of the technical means and its subsystems providing achievement of extreme value of criterion of efficiency of functioning of a technical complex of the information management system is developed. The main attention is paid to the applied party of system researches of complex technical providing, in particular, to definition of criteria of quality of functioning of a technical complex, development of methods of the analysis of information base of the information management system and definition of requirements to technical means, and also methods of structural synthesis of the main subsystems of complex technical providing. Thus, the purpose is research on the basis of system approach of complex technical providing the information management system and development of a number of methods of the analysis and the synthesis of complex technical providing suitable for use in engineering practice of design of systems. The well-known paradox of development of management information consists of that parameters of the system, and consequently, and requirements to the complex hardware, can not be strictly reasonable to development of algorithms and programs, and vice versa. The possible method of overcoming of these difficulties is prognostication of structure and parameters of complex hardware for certain management informations on the early stages of development, with subsequent clarification and