WorldWideScience

Sample records for cell renewal systems

  1. Radiobiology of Cell Renewal Systems

    Energy Technology Data Exchange (ETDEWEB)

    Patt, H. M. [Laboratory of Radiobiology, University of California Medical Center, San Francisco, CA (United States)

    1968-08-15

    In recent years, considerable attention has been given to quantitative aspects of radiation effects on cell renewal systems. The behaviour of stem-type cells has been a focal point of interest, and it has been assumed by many that the fraction of surviving stem cells is the principal determinant of the probability of survival of the irradiated system or organism. The apparent close similarity in dose requirements for impairment of reproductive capacity, and the similarity in early repair and in stage sensitivity in vitro and in vivo.clearly indicate that purely cellular phenomena are reflected in the organized population. It does not necessarily follow, however, that there is a straightforward relationship between radiation effects on stem cells and the response of systems or organisms. Indeed, this is not so. It is abundantly clear that differential radiosensitivity is anchored in a number of variables that are associated with the organizational framework of the system and its environment. Many, but not all, effects can be understood in terms of the normal kinetics of the developmental pathway. Yet, deviations from normal kinetics that are minor in the steady state can have profound significance in the perturbed state. To understand the radiobiology of cell renewal systems and to place the many possible variables in reasonable perspective, we need to know a good deal more about the interplay of the component parts than we do at present. When we view the totality of an organized cell population, it seems necessary to postulate mechanisms external to any given cell in the regulation of the balanced sequence of proliferation and differentiation. At present, we have only a vague idea about this. Most attention has been directed to the proliferative process and it is encouraging to note the growing interest in the more developmental facets of cell renewal. (author)

  2. Adaptation of cell renewal systems under continuous irradiation

    International Nuclear Information System (INIS)

    Fabrikant, J.I.

    1987-01-01

    There are adaptive changes in the proliferative characteristics of renewal tissues under the stress of continuous low-dose-rate irradiation which indicate that cell and tissue kinetics will have a considerable effect on the radiation response. Factors that determine the adaptation response involve cellular radiosensitivity, i.e. cell cycle effects, which determine the rate of cell sterilization and death, and compensatory cell proliferation and the capacity for regeneration, i.e. changes in the patterns of cell population kinetics, which determine the rate of cell birth. In rapidly dividing cell renewal systems, there is an effective elimination of damaged cells, with almost complete repair of cellular nonlethal damage. In slowly dividing renewal tissues, there is some repair or elimination of cellular radiation damage and the pattern of cell proliferation during regeneration is relatively little disturbed by prior continuous irradiation. Experimental data on intestinal epithelium, immunohematopoietic tissues, seminiferous epithelium and regenerating liver are presented. Discussion includes differences in adaptation to continuous low-dose-rate irradiation involving intracellular and extracellular control mechanisms which regulate cellular proliferation and differentiation and, thereby, control cell population levels and physiological function. 29 references

  3. Structure and function of stem cell pools in mammalian cell renewal systems

    International Nuclear Information System (INIS)

    Fliedner, T.M.; Nothdurft, W.

    1979-01-01

    Stem cells play a key-role in the maintenance of the equilibrium between cell loss and cell production in cell renewal systems as well as in the understanding of the radiation pathophysiology of mammalian organisms. The integrity of mammalian organisms with the need to maintain a constant ''millieu interior'' is depending on the normal functioning of cell renewal systems, especially those of epithelial surfaces and blood cell forming organs. All cell renewal systems of bodies have a very similar functional structure consisting of functional, proliferative - amplifying and stem cell compartments. They differ in transit and cell cycle times and in the number of amplification division - aside from the difference in their functional and biochemical make-up. The stem cell pools are providing the cells capable of differentiation without depleting their own kind. This can be achieved by symmetrical or assymmetrical stem cell division. In normal steady state, 50% of the stem cell division remain in the stem cell pool, while the other 50% leave it to differentiate, proliferate and mature, hemopoietic system is distributed throughout bodies. This is an important factor in the radiation biology of mammalian organisms since the loss of function in one area can be compensated for by more production in other areas, and locally depleted sites can be reseeded with the stem cells migrating in from blood. (Yamashita, S.)

  4. System and method for integration of renewable energy and fuel cell for the production of electricity and hydrogen

    NARCIS (Netherlands)

    Hemmes, K.

    2007-01-01

    The invention relates to a system and method for integrating renewable energy and a fuel cell for the production of electricity and hydrogen, wherein this comprises the use of renewable energy as fluctuating energy source for the production of electricity and also comprises the use of at least one

  5. [Studies on a sequential injection renewable surface reflectance spectrophotometric system using a microchip flow cell].

    Science.gov (United States)

    Wang, Jian-ya; Fang, Zhao-lun

    2002-02-01

    A microchip flow cell was developed for flow injection renewable surface assay by reflectance spectrophotometry. The flow cell was coupled to a sequential injection system and optical fiber photometric detection system. The flow cell featured a three-layer structure. The flow channel was cut into a silicone rubber membrance which formed the middle layer, and a porous filter was inlayed across a widened section of the channel to trap microbeads introduced into the flow cell. The area of the detection window of the flow cell was approximately 3.6 mm2, the volume of the bead trapped in the flow cell was 2.2 microL, the depth of the bead layer was 600 microns. A multistrand bifurcated optical fiber was coupled with incident light, detector and flow cell. The chromogenic reaction of Cr(VI) with 1,5-diphenylcarbohydrazide (DPC) which was adsorbed on trapped Polysorb C-18 beads was used as a model reaction to optimize the flow cell design and the experimental system. The reflectance of the renewable reaction surface was monitored at 540 nm. With 100 microL sample loaded and 1.0 mL.min-1 carrier flow rate, the linear response range was 0-0.6 microgram.mL-1 Cr(VI). A detection limit (3 sigma) of 6 ng.mL-1, precision of 1.5% RSD(n = 11), and a throughput of 64 samples per hour were achieved. Considerations in system and flow cell design, the influence of depth of the bead layer, weight of beads used, and the flow rates of carrier stream on the performance were discussed.

  6. Renewable Energy Tracking Systems

    Science.gov (United States)

    Renewable energy generation ownership can be accounted through tracking systems. Tracking systems are highly automated, contain specific information about each MWh, and are accessible over the internet to market participants.

  7. Reversible solid oxide fuel cell for natural gas/renewable hybrid power generation systems

    Science.gov (United States)

    Luo, Yu; Shi, Yixiang; Zheng, Yi; Cai, Ningsheng

    2017-02-01

    Renewable energy (RE) is expected to be the major part of the future energy. Presently, the intermittence and fluctuation of RE lead to the limitation of its penetration. Reversible solid oxide fuel cell (RSOFC) as the energy storage device can effectively store the renewable energy and build a bidirectional connection with natural gas (NG). In this paper, the energy storage strategy was designed to improve the RE penetration and dynamic operation stability in a distributed system coupling wind generators, internal combustion engine, RSOFC and lithium-ion batteries. By compromising the relative deviation of power supply and demand, RE penetration, system efficiency and capacity requirement, the strategy that no more than 36% of the maximum wind power output is directly supplied to users and the other is stored by the combination of battery and reversible solid oxide fuel cell is optimal for the distributed system. In the case, the RE penetration reached 56.9% and the system efficiency reached 55.2%. The maximum relative deviation of power supply and demand is also lower than 4%, which is significantly superior to that in the wind curtailment case.

  8. Renewable Energy Devices and Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Ionel, Dan M.

    2015-01-01

    In this paper, essential statistics demonstrating the increasing role of renewable energy generation are firstly discussed. A state of the art review section covers fundamentals of wind turbines and PV systems. Included are schematic diagrams illustrating the main components and system topologies...... and the fundamental and increasing role of power electronics as an enabler for renewable energy integration, and for the future power system and smart grid. Recent examples of research and development, including new devices and system installations for utility power plants, as well for as residential and commercial......, fuel cells, and storage with batteries and hydrogen, respectively. Recommended further readings on topics of electric power engineering for renewable energy are included in a final section. This paper also represents an editorial introduction for two special issues of the Electric Power Component...

  9. Understanding renewable energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Quaschning, Volker

    2005-01-15

    Beginning with an overview of renewable energy sources including biomass, hydroelectricity, geothermal, tidal, wind and solar power, this book explores the fundamentals of different renewable energy systems. The main focus is on technologies with high development potential such as solar thermal systems, photovoltaics and wind power. This text not only describes technological aspects, but also deals consciously with problems of the energy industry. In this way, the topics are treated in a holistic manner, bringing together maths, engineering, climate studies and economics, and enabling readers to gain a broad understanding of renewable energy technologies and their potential. The book also contains a free CD-ROM resource, which includes a variety of specialist simulation software and detailed figures from the book. (Author)

  10. Renewable Energy Systems

    DEFF Research Database (Denmark)

    Lund, Henrik; Mathiesen, Brian Vad; Connolly, David

    2014-01-01

    on the electricity sector, smart energy systems include the entire energy system in its approach to identifying suitable energy infrastructure designs and operation strategies. The typical smart grid sole focus on the electricity sector often leads to the conclusion that transmission lines, flexible electricity......This paper presents the learning of a series of studies that analyse the problems and perspectives of converting the present energy system into a 100 % renewable energy system using a smart energy systems approach. As opposed to, for instance, the smart grid concept, which takes a sole focus...... are to be found when the electricity sector is combined with the heating and cooling sectors and/or the transportation sector. Moreover, the combination of electricity and gas infrastructures may play an important role in the design of future renewable energy systems. The paper illustrates why electricity smart...

  11. Design, Operation, Control, and Economics of a Photovoltaic/Fuel Cell/Battery Hybrid Renewable Energy System for Automotive Applications

    Directory of Open Access Journals (Sweden)

    Zachary S. Whiteman

    2015-06-01

    Full Text Available Meeting rapidly growing global energy demand—without producing greenhouse gases or further diminishing the availability of non-renewable resources—requires the development of affordable low-emission renewable energy systems. Here, we develop a hybrid renewable energy system (HRES for automotive applications—specifically, a roof-installed photovoltaic (PV array combined with a PEM fuel cell/NiCd battery bus currently operating shuttle routes on the University of Delaware campus. The system’s overall operating objectives—meeting the total power demand of the bus and maintaining the desired state of charge (SOC of the NiCd battery—are achieved with appropriately designed controllers: a logic-based “algebraic controller” and a standard PI controller. The design, implementation, and performance of the hybrid system are demonstrated via simulation of real shuttle runs under various operating conditions. The results show that both control strategies perform equally well in enabling the HRES to meet its objectives under typical operating conditions, and under sudden cloud cover conditions; however, at consistently high bus speeds, battery SOC maintenance is better, and the system consumes less hydrogen, with PI control. An economic analysis of the PV investment necessary to realize the HRES design objectives indicates a return on investment of approximately 30% (a slight, but nonetheless positive, ~$550 profit over the bus lifetime in Newark, DE, establishing the economic viability of the proposed addition of a PV array to the existing University of Delaware fuel cell/battery bus.

  12. Satellite Cell Self-Renewal.

    Science.gov (United States)

    Giordani, Lorenzo; Parisi, Alice; Le Grand, Fabien

    2018-01-01

    Adult skeletal muscle is endowed with regenerative potential through partially recapitulating the embryonic developmental program. Upon acute injury or in pathological conditions, quiescent muscle-resident stem cells, called satellite cells, become activated and give rise to myogenic progenitors that massively proliferate, differentiate, and fuse to form new myofibers and restore tissue functionality. In addition, a proportion of activated cells returns back to quiescence and replenish the pool of satellite cells in order to maintain the ability of skeletal muscle tissue to repair. Self-renewal is the process by which stem cells divide to make more stem cells to maintain the stem cell population throughout life. This process is controlled by cell-intrinsic transcription factors regulated by cell-extrinsic signals from the niche and the microenvironment. This chapter provides an overview about the general aspects of satellite cell biology and focuses on the cellular and molecular aspects of satellite cell self-renewal. To date, we are still far from understanding how a very small proportion of the satellite cell progeny maintain their stem cell identity when most of their siblings progress through the myogenic program to construct myofibers. © 2018 Elsevier Inc. All rights reserved.

  13. Adaptive control paradigm for photovoltaic and solid oxide fuel cell in a grid-integrated hybrid renewable energy system

    Science.gov (United States)

    Khan, Laiq

    2017-01-01

    The hybrid power system (HPS) is an emerging power generation scheme due to the plentiful availability of renewable energy sources. Renewable energy sources are characterized as highly intermittent in nature due to meteorological conditions, while the domestic load also behaves in a quite uncertain manner. In this scenario, to maintain the balance between generation and load, the development of an intelligent and adaptive control algorithm has preoccupied power engineers and researchers. This paper proposes a Hermite wavelet embedded NeuroFuzzy indirect adaptive MPPT (maximum power point tracking) control of photovoltaic (PV) systems to extract maximum power and a Hermite wavelet incorporated NeuroFuzzy indirect adaptive control of Solid Oxide Fuel Cells (SOFC) to obtain a swift response in a grid-connected hybrid power system. A comprehensive simulation testbed for a grid-connected hybrid power system (wind turbine, PV cells, SOFC, electrolyzer, battery storage system, supercapacitor (SC), micro-turbine (MT) and domestic load) is developed in Matlab/Simulink. The robustness and superiority of the proposed indirect adaptive control paradigm are evaluated through simulation results in a grid-connected hybrid power system testbed by comparison with a conventional PI (proportional and integral) control system. The simulation results verify the effectiveness of the proposed control paradigm. PMID:28329015

  14. Adaptive control paradigm for photovoltaic and solid oxide fuel cell in a grid-integrated hybrid renewable energy system.

    Science.gov (United States)

    Mumtaz, Sidra; Khan, Laiq

    2017-01-01

    The hybrid power system (HPS) is an emerging power generation scheme due to the plentiful availability of renewable energy sources. Renewable energy sources are characterized as highly intermittent in nature due to meteorological conditions, while the domestic load also behaves in a quite uncertain manner. In this scenario, to maintain the balance between generation and load, the development of an intelligent and adaptive control algorithm has preoccupied power engineers and researchers. This paper proposes a Hermite wavelet embedded NeuroFuzzy indirect adaptive MPPT (maximum power point tracking) control of photovoltaic (PV) systems to extract maximum power and a Hermite wavelet incorporated NeuroFuzzy indirect adaptive control of Solid Oxide Fuel Cells (SOFC) to obtain a swift response in a grid-connected hybrid power system. A comprehensive simulation testbed for a grid-connected hybrid power system (wind turbine, PV cells, SOFC, electrolyzer, battery storage system, supercapacitor (SC), micro-turbine (MT) and domestic load) is developed in Matlab/Simulink. The robustness and superiority of the proposed indirect adaptive control paradigm are evaluated through simulation results in a grid-connected hybrid power system testbed by comparison with a conventional PI (proportional and integral) control system. The simulation results verify the effectiveness of the proposed control paradigm.

  15. Battery storage for supplementing renewable energy systems

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2009-01-18

    The battery storage for renewable energy systems section of the Renewable Energy Technology Characterizations describes structures and models to support the technical and economic status of emerging renewable energy options for electricity supply.

  16. Introduction to Renewable Energy Systems

    DEFF Research Database (Denmark)

    Ma, Ke; Yang, Yongheng; Blaabjerg, Frede

    2014-01-01

    . It is concluded that as the quick development of renewable energy, wind power and PV power both show great potential to be largely integrated into the power grid. Power electronics is playing essential role in both of the systems to achieve more controllable, efficient, and reliable energy production......In this chapter, the state-of-the-arts developments of renewable energy are reviewed in respect to the installed power and market share, where wind power and photovoltaic power generation are the main focuses due to the fast growing speed and large share of installed capacity. Some basic principles...... of operation, mission profiles, as well as power electronics solutions and corresponding controls are discussed respectively in the case of wind power and photovoltaic power systems. Finally a few development trends for renewable energy conversions are also given from a power electronics point of view...

  17. Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks.

    Science.gov (United States)

    Dowell, Karen G; Simons, Allen K; Bai, Hao; Kell, Braden; Wang, Zack Z; Yun, Kyuson; Hibbs, Matthew A

    2014-05-01

    Embryonic stem cells (ESCs), characterized by their ability to both self-renew and differentiate into multiple cell lineages, are a powerful model for biomedical research and developmental biology. Human and mouse ESCs share many features, yet have distinctive aspects, including fundamental differences in the signaling pathways and cell cycle controls that support self-renewal. Here, we explore the molecular basis of human ESC self-renewal using Bayesian network machine learning to integrate cell-type-specific, high-throughput data for gene function discovery. We integrated high-throughput ESC data from 83 human studies (~1.8 million data points collected under 1,100 conditions) and 62 mouse studies (~2.4 million data points collected under 1,085 conditions) into separate human and mouse predictive networks focused on ESC self-renewal to analyze shared and distinct functional relationships among protein-coding gene orthologs. Computational evaluations show that these networks are highly accurate, literature validation confirms their biological relevance, and reverse transcriptase polymerase chain reaction (RT-PCR) validation supports our predictions. Our results reflect the importance of key regulatory genes known to be strongly associated with self-renewal and pluripotency in both species (e.g., POU5F1, SOX2, and NANOG), identify metabolic differences between species (e.g., threonine metabolism), clarify differences between human and mouse ESC developmental signaling pathways (e.g., leukemia inhibitory factor (LIF)-activated JAK/STAT in mouse; NODAL/ACTIVIN-A-activated fibroblast growth factor in human), and reveal many novel genes and pathways predicted to be functionally associated with self-renewal in each species. These interactive networks are available online at www.StemSight.org for stem cell researchers to develop new hypotheses, discover potential mechanisms involving sparsely annotated genes, and prioritize genes of interest for experimental validation

  18. Renewable energy covernance systems

    International Nuclear Information System (INIS)

    Hvelplund, F.

    2001-01-01

    The 'political quota-/certificate price market' system introduces an inefficient competition between energy robots, and weakens the increasingly important competition between equipment producers. It hampers the competition between investors by making it difficult for neighbours and local investors to invest in wind turbines. Due to its mono price character, it gives too high profits to wind turbine owners at very good wind sites, and not high enough to wind turbine owners at poor wind sites. The 'political quota-/certificate price market' system is very far from being a market model, as the RE amount is politically decided and the certificate market price is also political influenced. The conclusion, therefore, is that it is time to find a RE governance model that considers the specific needs and characteristics of RE technologies. The present analysis strongly indicates that a 'political price-/amount market' model in this connection is far better than the 'political quota-/certificate price market' model. Furthermore, a common EU model, based on the principle of site efficiency, would be much more flexible, cheaper and easier to pursue than the 'political quota-/certificate price market', or mono price model, which is designed for uranium and fossil fuel technologies, and represents a governance model designed for the technologies of yesterday. (EHS)

  19. Renewable Energy Systems: Technology Overview and Perspectives

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Ionel, Dan M.; Yang, Yongheng

    2017-01-01

    In this chapter, essential statistics demonstrating the increasing role of renewable energy generation are first discussed. A state-of-the-art review section covers the fundamentals of wind turbine and photovoltaic (PV) systems. Schematic diagrams illustrating the main components and system topol......, including PV and concentrating solar power; wave energy; fuel cells; and storage with batteries and hydrogen, respectively. Recommended further readings on topics of electric power engineering for renewable energy are included in the final section.......In this chapter, essential statistics demonstrating the increasing role of renewable energy generation are first discussed. A state-of-the-art review section covers the fundamentals of wind turbine and photovoltaic (PV) systems. Schematic diagrams illustrating the main components and system...... topologies are included. Also, the increasing role of power electronics is explained as an enabler for renewable energy integration and for future power systems and smart grids. Recent examples of research and development, including new devices and system installations for utility power plants...

  20. Techno-economic feasibility analysis of hydrogen fuel cell and solar photovoltaic hybrid renewable energy system for academic research building

    International Nuclear Information System (INIS)

    Singh, Anand; Baredar, Prashant; Gupta, Bhupendra

    2017-01-01

    Highlights: • A HFC and SPV HRES for stand-alone applications is proposed. • The FC program computes the optimum cost of HRES components. • HOMER pro software to calculate the optimum performance of HRES. - Abstract: A hydrogen fuel cell (HFC) and solar photovoltaic (SPV) hybrid renewable energy system (HRES) for stand-alone applications is proposed. This system arrangement of a hydrogen tank, battery, and an electrolyzer are used as like the energy storage. The economic viability of using HRES power to supply the electrical load demand of academic research building located at 23°12′N latitude and 77°24′E longitudes, India is examined. The fuzzy logic program computes the optimum value of capital and replacement cost of the components, which is then utilized in HOMER pro software to calculate the optimum performance of HRES. The results shows the HFC and battery bank are the most significant modules of the HRES to meet load demand at late night and early morning hours. The AC primary load consuming 20712.63 kWh/year out of total power generation of HRES which is 24570.72 kWh/year. The excess of electricity produced by HRES is 791.7709 kWh/year with the optimized cost of energy, unmet electrical load and capacity shortage of 0%.

  1. Fuel cells as renewable energy sources

    International Nuclear Information System (INIS)

    Cacciola, G.; Passalacqua, E.

    2001-01-01

    The technology level achieved in fuel cell (FC) systems in the last years has significantly increased the interest of various manufacturing industries engaged in energy production and distribution even under the perspectives that this technology could provide. Today, the fuel cells (FCs) can supply both electrical and thermal energy without using moving parts and with a high level of affordability with respect to the conventional systems. FCs can utilise every kind of fuel such as hydrocarbons, hydrogen available from the water through renewable sources (wind, solar energy), alcohol etc. Thus, they may find application in many field ranging from energy production in large or small plants to the cogeneration systems for specific needs such as for residential applications, hospitals, industries, electric vehicles and portable power sources. Low temperature polymer electrolyte fuel cells (PEFC, DMFC) are preferred for application in the field of transportation and portable systems. The CNR-ITAE research activity in this field concerns the development of technologies, materials and components for the entire system: electrocatalysts, conducting supports, electrolytes, manufacturing technologies for the electrodes-electrolyte assemblies and the attainment of fuel cells with high power densities. Furthermore, some activities have been devoted to the design and realisation of PEFC fuel cell prototypes with rated power lower than I kW for stationary and mobile applications [it

  2. Modeling and Optimization of Renewable and Hybrid Fuel Cell Systems for Space Power and Propulsion

    Science.gov (United States)

    2010-11-14

    electrolyser (Hogen GC 600) which splits the water molecule into hydrogen and oxygen molecules. The produced hydrogen supplies the fuel cell stack and the...allows the water vapor to be condensed and returned to the electrolyser for consumption will be required. Those items were not available commercially to...charged continuously. The batteries then feed an electrolyzer, which fills up an H2 reservoir that feeds a NEXA 1.2 kW PEMFC stack. The water produced in

  3. Integrating renewables into energy systems

    International Nuclear Information System (INIS)

    1999-03-01

    An analysis of renewable energy schemes was undertaken via case studies in China, India, Indonesia, Kenya, South Africa, Thailand and Zimbabwe, that provided an insight into the application of best practice for overcoming market, technical and financial barriers to the establishment of the sustainable markets required for the large-scale deployment of renewable energy technologies. The project showed clearly the need to select and target interventions according to the context. Lessons were extracted against a number of themes, as well as against the various technologies analysed and simple guides to the principles of best practice were derived under the following headings:- experience of gaining access to (micro) finance; the technical and non-technical issues raised when small, typically independent, generators seek access to central electricity grid systems; how to best undertake awareness raising and dissemination activities; promoting, building and operating biogas systems; promoting, building and operating solar (photovoltaic) home systems; promoting, building and operating grid connected wind power; promoting, building and operating solar hot water systems; promoting agricultural cogeneration using crop residues. (author)

  4. Renewable and efficient electric power systems

    CERN Document Server

    Masters, Gilbert M

    2013-01-01

    A solid, quantitative, practical introduction to a wide range of renewable energy systems-in a completely updated, new edition The second edition of Renewable and Efficient Electric Power Systems provides a solid, quantitative, practical introduction to a wide range of renewable energy systems. For each topic, essential theoretical background is introduced, practical engineering considerations associated with designing systems and predicting their performance are provided, and methods for evaluating the economics of these systems are presented. While the book focuses on

  5. Renewable energy delivery systems and methods

    Science.gov (United States)

    Walker, Howard Andrew

    2013-12-10

    A system, method and/or apparatus for the delivery of energy at a site, at least a portion of the energy being delivered by at least one or more of a plurality of renewable energy technologies, the system and method including calculating the load required by the site for the period; calculating the amount of renewable energy for the period, including obtaining a capacity and a percentage of the period for the renewable energy to be delivered; comparing the total load to the renewable energy available; and, implementing one or both of additional and alternative renewable energy sources for delivery of energy to the site.

  6. Autonomous renewable energy conversion system

    Energy Technology Data Exchange (ETDEWEB)

    Valtchev, V. [Technical University of Varna (Bulgaria). Dept. of Electronics; Bossche, A. van den; Ghijselen, J.; Melkebeek, J. [University of Gent (Belgium). Dept. of Electrical Power Engineering

    2000-02-01

    This paper briefly reviews the need for renewable power generation and describes a medium-power Autonomous Renewable Energy Conversion System (ARECS), integrating conversion of wind and solar energy sources. The objectives of the paper are to extract maximum power from the proposed wind energy conversion scheme and to transfer this power and the power derived by the photovoltaic system in a high efficiency way to a local isolated load. The wind energy conversion operates at variable shaft speed yielding an improved annual energy production over constant speed systems. An induction generator (IG) has been used because of its reduced cost, robustness, absence of separate DC source for excitation, easier dismounting and maintenance. The maximum energy transfer of the wind energy is assured by a simple and reliable control strategy adjusting the stator frequency of the IG so that the power drawn is equal to the peak power production of the wind turbine at any wind speed. The presented control strategy also provides an optimal efficiency operation of the IG by applying a quadratic dependence between the IG terminal voltage and frequency V {approx} f{sup 2}. For improving the total system efficiency, high efficiency converters have been designed and implemented. The modular principle of the proposed DC/DC conversion provides the possibility for modifying the system structure depending on different conditions. The configuration of the presented ARECS and the implementation of the proposed control algorithm for optimal power transfer are fully discussed. The stability and dynamic performance as well as the different operation modes of the proposed control and the operation of the converters are illustrated and verified on an experimental prototype. (author)

  7. Potential of renewable energy systems in China

    DEFF Research Database (Denmark)

    Liu, Wen; Lund, Henrik; Mathiesen, Brian Vad

    2011-01-01

    Along with high-speed economic development and increasing energy consumption, the Chinese Government faces a growing pressure to maintain the balance between energy supply and demand. In 2009, China has become both the largest energy consumer and CO2 emitting country in the world. In this case...... system has demonstrated the possibility of converting into a 100% renewable energy system. This paper discusses the perspective of renewable energy in China firstly, and then analyses whether it is suitable to adopt similar methodologies applied in other countries as China approaches a renewable energy...... system. The conclusion is that China’s domestic renewable energy sources are abundant and show the possibility to cover future energy demand; the methodologies used to analyse a 100% renewable energy system are applicable in China. Therefore, proposing an analysis of a 100% renewable energy system...

  8. Spermatogonial stem cell renewal following irradiation

    International Nuclear Information System (INIS)

    Fabrikant, J.I.

    1979-05-01

    The spermatogonial cell renewal system can maintain function and a steady level of cell population for relatively long periods of continuous low-level irradiation indicating that there does not appear to be a serious accumulation, over many generations, of damage affecting proliferation. Provided the dose-rate is quite low, there is an effective selective removal of damaged cells with almost complete repair of cellular nonlethal damage. At dose-rates greater than 2 rad/day, spermatogonia are very sensitive to radiation death, and the main reason for the low tolerance to continuous stress could, in part, be the limited extent of compensatory mechanisms regulating spermatogonial cell production. However, there is some capacity to change the patterns of cellular proliferation while still remaining under homeostatic control, and this capacity appears to reside in the relatively radioresistant A/sub s/ stem-cell population. Little is known about the extent to which the spermatogonial cell population can repair nonlethal cellular radiation damage accumulated under continuous stress affecting the regenerative capacity of the tissue. After acute exposure, a minimum number of surviving type A/sub s/ stem-cells are required to repopulate the functional seminiferous epithelium, regeneration proceeds along an ordered cell stage sequence, and is dependent on the time required for all stages from type A/sub s/ spermatogonia to mature spermatozoa. Under continuous irradiation, provided the dose-rate is not too high, the repopulating ability of the seminiferous epithelium is maintained, in the presence of injury, due to initial repair and long-term repair of cellular radiation damage. There is evidence for initial repair, since a dose-rate effect exists in type A survival, at low doses. Long-term repair occurs due to differential radiosensitivities of spermatogonia

  9. Fuel Cells for Balancing Fluctuation Renewable Energy Sources

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad

    2007-01-01

    In the perspective of using fuel cells for integration of fluctuating renewable energy the SOFCs are the most promising. These cells have the advantage of significantly higher electricity efficiency than competing technologies and fuel flexibility. Fuel cells in general also have the advantage of...... with hydrogen production or electric cars, and on the other hand using biomass and bio fuels [11]. Fuel cells can have an important role in these future energy systems.......In the perspective of using fuel cells for integration of fluctuating renewable energy the SOFCs are the most promising. These cells have the advantage of significantly higher electricity efficiency than competing technologies and fuel flexibility. Fuel cells in general also have the advantage...... flexibility, such as SOFCs, heat pumps and heat storage technologies are more important than storing electricity as hydrogen via electrolysis in energy systems with high amounts of wind [12]. Unnecessary energy conversions should be avoided. However in future energy systems with wind providing more than 50...

  10. Potential of renewable energy systems in China

    International Nuclear Information System (INIS)

    Liu, Wen; Lund, Henrik; Mathiesen, Brian Vad; Zhang, Xiliang

    2011-01-01

    Along with high-speed economic development and increasing energy consumption, the Chinese Government faces a growing pressure to maintain the balance between energy supply and demand. In 2009, China has become both the largest energy consumer and CO 2 emitting country in the world. In this case, the inappropriate energy consumption structure should be changed. As an alternative, a suitable infrastructure for the implementation of renewable energy may serve as a long-term sustainable solution. The perspective of a 100% renewable energy system has been analyzed and discussed in some countries previously. In this process, assessment of domestic renewable energy sources is the first step. Then appropriate methodologies are needed to perform energy system analyses involving the integration of more sustainable strategies. Denmark may serve as an example of how sustainable strategies can be implemented. The Danish system has demonstrated the possibility of converting into a 100% renewable energy system. This paper discusses the perspective of renewable energy in China firstly, and then analyses whether it is suitable to adopt similar methodologies applied in other countries as China approaches a renewable energy system. The conclusion is that China's domestic renewable energy sources are abundant and show the possibility to cover future energy demand; the methodologies used to analyse a 100% renewable energy system are applicable in China. Therefore, proposing an analysis of a 100% renewable energy system in China is not unreasonable. (author)

  11. Renewal Processes and Repairable Systems

    NARCIS (Netherlands)

    2003-01-01

    In this thesis we discuss the following topics: 1. Renewal reward processes The marginal distributions of renewal reward processes and its version, which we call in this thesis instantaneous reward processes, are derived. Our approach is based on the theory of point processes, especially Poisson

  12. Power Electronics for Renewable Energy Systems

    DEFF Research Database (Denmark)

    Choi, U. M.; Lee, K. B.; Blaabjerg, Frede

    2012-01-01

    The use of renewable energy sources are increased because of the depletion of natural resources and the increasing pollution level from energy production. The wind energy and the solar energy are most widely used among the renewable energy sources. Power electronics is needed in almost all kinds...... of renewable energy system. It controls the renewable source and interfaces with the load effectively, which can be grid-connected or van work in stand-alone mode. In this presentation, overview of wind and photovoltaic energy systems are introduced. Next, the power electronic circuits behind the most common...

  13. Haemopoietic cell renewal in radiation fields

    Science.gov (United States)

    Fliedner, T. M.; Nothdurft, W.; Tibken, B.; Hofer, E.; Weiss, M.; Kindler, H.

    1994-10-01

    Space flight activities are inevitably associated with a chronic exposure of astronauts to a complex mixture of ionising radiation. Although no acute radiation consequences are to be expected as a rule, the possibility of Solar Particle Events (SPE) associated with relatively high doses of radiation (1 or more Gray) cannot be excluded. It is the responsibility of physicians in charge of the health of astronauts to evaluate before, during and after space flight activities the functional status of haemopoietic cell renewal. Chronic low level exposure of dogs indicate that daily gamma-exposure doses below about 2 cGy are tolerated for several years as far as blood cell concentrations are concerned. However, the stem cell pool may be severely affected. The maintenance of sufficient blood cell counts is possible only through increased cell production to compensate for the radiation inflicted excess cell loss. This behaviour of haemopoietic cell renewal during chronic low level exposure can be simulated by bioengineering models of granulocytopoiesis. It is possible to define a ``turbulence region'' for cell loss rates, below which an prolonged adaptation to increased radiation fields can be expected to be tolerated. On the basis of these experimental results, it is recommended to develop new biological indicators to monitor haemopoietic cell renewal at the level of the stem cell pool using blood stem cells in addition to the determination of cytokine concentrations in the serum (and other novel approaches). To prepare for unexpected haemopoietic effects during prolonged space missions, research should be increased to modify the radiation sensitivity of haemopoietic stem cells (for instance by the application of certain regulatory molecules). In addition, a ``blood stem cell bank'' might be established for the autologous storage of stem cells and for use in space activities keeping them in a radiation protected container.

  14. The Palm Desert renewable [hydrogen] transportation system

    Energy Technology Data Exchange (ETDEWEB)

    Chamberlin, C.E.; Lehman, P. [Humboldt State Univ., Arcata, CA (United States). Schatz Energy Research Center

    1998-08-01

    This paper describes the Schatz Energy Research Center (SERC) progress on the Palm Desert Renewable Hydrogen Transportation System Project for the period June 1997 through May 1998. The project began in March 1996. The goal of the Palm Desert Project is to develop a clean and sustainable transportation system for a community. The project demonstrates the practical utility of hydrogen as a transportation fuel and the proton exchange membrane (PEM) fuel cell as a vehicle power system. The project includes designing and building 4 fuel cell powered vehicles, a solar hydrogen generating and refueling station, and a fuel cell vehicle diagnostic center. Over this last year, SERC has built a fuel cell powered neighborhood electric vehicle and delivered it to the City of Palm Desert. The design of the hydrogen refueling station is near completion and it is anticipated that construction will be complete in the fall of 1998. The vehicles are currently being refueled at a temporary refueling station. The diagnostic center is being designed and maintenance procedures as well as computer diagnostic programs for the fuel cell vehicles are being developed. City employees are driving the vehicles daily and monitoring data are being collected. The drivers are pleased with the performance of the vehicles.

  15. Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation

    OpenAIRE

    Mei, Xing-Xing; Wang, Jian; Wu, Ji

    2015-01-01

    Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems have greatly expanded our understanding of SSC self-renewal and differentiation. Many important molecules crucial for the balance between self-renewal and differentiation have been recently identi...

  16. Power Converters and Control of Renewable Energy Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Teodorescu, Remus; Chen, Zhe

    2004-01-01

    The global electrical energy consumption is steadily rising and therefore a continuous demand to increase the power generation capacity. A significant percentage of the required capacity increase can be based on renewable energy sources. Wind turbine technology, as the most cost effective renewable...... energy conversion system, will play an important part in our future energy supply. But other sources like microturbines, photovoltaics and fuel cell systems may also be serious contributor to the power supply. Characteristically, power electronics will be an efficient and important interface to the grid...... for the renewables and this paper will first briefly discuss three different alternative/renewable energy sources. Next, various configurations of small and medium power conversion topologies are presented including their control (mainly for PV-systems). Finally wind turbine configuration and their control...

  17. Implementation of Renewable Energy Systems in Denmark

    DEFF Research Database (Denmark)

    Meyer, Niels I

    1997-01-01

    Denmark has been one of the first countries in the world to commit itself to a sustainable energy development. This has been substantiated by two official action plans from 1990 and 1996 with emphasis on energy efficiency and supply systems based on renewable energy. In year 2005, renewable energy...... sources are planned to cover 12-14% and in year 2030 about 35% of total Danish energy demand. This paper reviews the experiences with implementation of renewable energy in Denmark with a focus on wind power and biomass....

  18. Power electronics for renewable energy systems

    DEFF Research Database (Denmark)

    Iov, Florin; Blaabjerg, Frede

    2009-01-01

    sources from the conventional, fossil (and short term) based energy sources to renewable energy resources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss some of the most emerging renewable energy sources......, wind energy and photovoltaics, which by means of power electronics are changing from being minor energy sources to be acting as important power sources in the energy system....

  19. Electric vehicles and renewable energy in the transport sector - energy system consequences. Main focus: Battery electric vehicles and hydrogen based fuel cell vehicles

    DEFF Research Database (Denmark)

    Nielsen, L.H.; Jørgensen K.

    2000-01-01

    The aim of the project is to analyse energy, environmental and economic aspects of integrating electric vehicles in the future Danish energy system. Consequences of large-scale utilisation of electric vehicles are analysed. The aim is furthermore toillustrate the potential synergistic interplay...... between the utilisation of electric vehicles and large-scale utilisation of fluctuating renewable energy resources, such as wind power. Economic aspects for electric vehicles interacting with a liberalisedelectricity market are analysed. The project focuses on battery electric vehicles and fuel cell...... vehicles based on hydrogen. Based on assumptions on the future technical development for battery electric vehicles, fuel cell vehicles on hydrogen, and forthe conventional internal combustion engine vehicles, scenarios are set up to reflect expected options for the long-term development of road transport...

  20. Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation

    Directory of Open Access Journals (Sweden)

    Xing-Xing Mei

    2015-06-01

    Full Text Available Spermatogonial stem cells (SSCs, the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems have greatly expanded our understanding of SSC self-renewal and differentiation. Many important molecules crucial for the balance between self-renewal and differentiation have been recently identified although the exact mechanism(s remain largely undefined. In this review, we give a brief introduction to SSCs, and then focus on extrinsic and intrinsic factors controlling SSCs self-renewal and differentiation.

  1. Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation.

    Science.gov (United States)

    Mei, Xing-Xing; Wang, Jian; Wu, Ji

    2015-01-01

    Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems have greatly expanded our understanding of SSC self-renewal and differentiation. Many important molecules crucial for the balance between self-renewal and differentiation have been recently identified although the exact mechanism(s) remain largely undefined. In this review, we give a brief introduction to SSCs, and then focus on extrinsic and intrinsic factors controlling SSCs self-renewal and differentiation.

  2. Career Directions--Renewable Energy Systems Integrator

    Science.gov (United States)

    Fleeman, Stephen R.

    2012-01-01

    Renewable energy systems are beginning to appear everywhere. Solar modules are creating "blue roofs" that convert the energy from the sun into household electricity. Solar thermal systems on roofs can generate hot water. Wind turbines catch breezes to provide even more electricity. Recommendations for saving energy, specifying systems for…

  3. Power electronics for renewable and distributed energy systems a sourcebook of topologies, control and integration

    CERN Document Server

    Chakraborty, Sudipta; Kramer, William E

    2013-01-01

    While most books approach power electronics and renewable energy as two separate subjects, Power Electronics for Renewable and Distributed Energy Systems takes an integrative approach; discussing power electronic converters topologies, controls and integration that are specific to the renewable and distributed energy system applications. An overview of power electronic technologies is followed by the introduction of various renewable and distributed energy resources that includes photovoltaics, wind, small hydroelectric, fuel cells, microturbines and variable speed generation. Energy storage s

  4. Self-renewal molecular mechanisms of colorectal cancer stem cells

    OpenAIRE

    Pan, Tianhui; Xu, Jinghong; Zhu, Yongliang

    2016-01-01

    Colorectal cancer stem cells (CCSCs) represent a small fraction of the colorectal cancer cell population that possess self-renewal and multi-lineage differentiation potential and drive tumorigenicity. Self-renewal is essential for the malignant biological behaviors of colorectal cancer stem cells. While the self-renewal molecular mechanisms of colorectal cancer stem cells are not yet fully understood, the aberrant activation of signaling pathways, such as Wnt, Notch, transforming growth facto...

  5. Autonomous Renewable Energy Systems | Van Voorden | Nigerian ...

    African Journals Online (AJOL)

    The problems of having many renewable sources such as wind and solar generating units in a power system are uncontrollable fluctuations in power generation and the difficulty in forecasting the power generation capability of these sources due to their stochastic nature. Therefore, autonomous electricity systems with a ...

  6. Stochastic hybrid systems with renewal transitions

    NARCIS (Netherlands)

    Guerreiro Tome Antunes, D.J.; Hespanha, J.P.; Silvestre, C.J.

    2010-01-01

    We consider Stochastic Hybrid Systems (SHSs) for which the lengths of times that the system stays in each mode are independent random variables with given distributions. We propose an analysis framework based on a set of Volterra renewal-type equations, which allows us to compute any statistical

  7. Design for Reliability in Renewable Energy Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Zhou, Dao; Sangwongwanich, Ariya

    2017-01-01

    Power electronics are widely used in renewable energy systems to achieve lower cost of energy, higher efficiency and high power density. At the same time, the high reliability of the power electronics products is demanded, in order to reduce the failure rates and ensure cost-effective operation...... of the renewable energy systems. This paper thus describes the basic concepts used in reliability engineering, and presents the status and future trends of Design for Reliability (DfR) in power electronics, which is currently undergoing a paradigm shift to a physics-of-failure approach. Two case studies of a 2 MW...

  8. Comparison between hybrid renewable energy systems in Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Hisham El Khashab

    2015-05-01

    This paper investigates RE sources applications at Yanbu, Saudi Arabia, besides a simulation using HOMER software to three proposed systems newly erected in Yanbu Industrial College Renewable Energy (RE lab. The lab represents a hybrid system, composed of PV, wind turbine, and Fuel cell systems. The cost of energy is compared in the three systems to have an actual estimation for RE in developing countries. The climatic variations at Yanbu that is located on the west coast of Saudi Arabia are considered.

  9. Probabilistic generation assessment system of renewable energy in Korea

    Directory of Open Access Journals (Sweden)

    Yeonchan Lee

    2016-01-01

    Full Text Available This paper proposes probabilistic generation assessment system introduction of renewable energy generators. This paper is focused on wind turbine generator and solar cell generator. The proposed method uses an assessment model based on probabilistic model considering uncertainty of resources (wind speed and solar radiation. Equivalent generation function of the wind and solar farms are evaluated. The equivalent generation curves of wind farms and solar farms are assessed using regression analysis method using typical least square method from last actual generation data for wind farms. The proposed model is applied to Korea Renewable Generation System of 8 grouped 41 wind farms and 9 grouped around 600 solar farms in South Korea.

  10. Integrated transport and renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, B.V.; Lund, H.; Nørgård, Per Bromand

    2007-01-01

    Governments worldwide aim at reducing CO2 emissions and expanding renewable energy. A key element in achieving such a goal is to use renewable energy in transport such as biofuels. However, efforts to promote single transport technologies and single fuels only represent a partial solution...... transport. It is concluded that a 100 per cent renewable energy transport system is possible but is connected to significant challenges in the path towards it. Biomass is a limited resource and it is important to avoid effecting the production. The integration of the transport with the remaining energy....... No single technology can solve the problem of ever increasing CO2 emissions from transport. Transport must be integrated into energy planning, as electricity and heating. In this paper, a coherent effort to integrate transport into energy planning is proposed, using multiple means promoting sustainable...

  11. Chaordic systems for holonic organizational renewal

    NARCIS (Netherlands)

    Eijnatten, van F.M.; Pasmore, W.A.; Woodman, R.W.

    2001-01-01

    Socio-Technical Systems Design has a long-standing reputation as an integral approach to organization design. One of its local brands is known as the Dutch approach to Integral Organizational Renewal of the firm (IOR). Central in IOR is an attempt to integrate both business process design,

  12. NAPS renewable energy systems R and D

    International Nuclear Information System (INIS)

    Spiers, D.J.

    1990-01-01

    Neste Advanced Power Systems (NAPS) is a renewable energy systems company supplying complete power systems based on photovoltaics, wind turbine generator, diesel generators, or hybrid systems combining two or more of these. Except for a few demonstration systems linked to the electricity grid, these are stand-alone power supplies which include storage batteries. Our present market areas are: Domestic systems for remote houses, largely in the Nordic countries. Systems for developing countries, mostly for lighting, health care and water supply and industrial and professional systems for use anywhere in the world, mainly for telecommunications and navigation aids

  13. Integrated Renewable Hydrogen Utility System (IRHUS) business plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This business plan is for a proposed legal entity named IRHUS, Inc. which is to be formed as a subsidiary of Energy Partners, L.C. (EP) of West Palm Beach, Florida. EP is a research and development company specializing in hydrogen proton exchange membrane (PEM) fuel cells and systems. A fuel cell is an engine with no moving parts that takes in hydrogen and produces electricity. The purpose of IRHUS, Inc. is to develop and manufacture a self-sufficient energy system based on the fuel cell and other new technology that produces hydrogen and electricity. The product is called the Integrated renewable Hydrogen utility System (IRHUS). IRHUS, Inc. plans to start limited production of the IRHUS in 2002. The IRHUS is a unique product with an innovative concept in that it provides continuous electrical power in places with no electrical infrastructure, i.e., in remote and island locations. The IRHUS is a zero emissions, self-sufficient, hydrogen fuel generation system that produces electricity on a continuous basis by combining any renewable power source with hydrogen technology. Current plans are to produce a 10 kilowatt IRHUS MP (medium power). Future plans are to design and manufacture IRHUS models to provide power for a variety of power ranges for identified attractive market segments. The technological components of the IRHUS include an electrolyzer, hydrogen and oxygen storage subsystems, fuel cell system, and power control system. The IRHUS product is to be integrated with a variety of renewable energy technologies. 5 figs., 10 tabs.

  14. Energy Systems With Renewable Hydrogen Compared to Direct Use of Renewable Energy in Austria

    International Nuclear Information System (INIS)

    Gerfried Jungmeier; Kurt Konighofer; Josef Spitzer; R Haas; A Ajanovic

    2006-01-01

    The current Austrian energy system has a renewable energy share of 20% - 11% hydropower and 9 % biomass - of total primary energy consumption. Whereas a possible future introduction of renewable hydrogen must be seen in the context of current energy policies in Austria e.g. increase of energy efficiency and use of renewable energy, reduction of greenhouse gas emissions. The aim of the research project is a life cycle based comparison of energy systems with renewable hydrogen from hydropower, wind, photovoltaic and biomass compared to the direct use of renewable energy for combined heat and power applications and transportation services. In particular this paper focuses on the main question, if renewable energy should be used directly or indirectly via renewable hydrogen. The assessment is based on a life cycle approach to analyse the energy efficiency, the material demand, the greenhouse gas emissions and economic aspects e.g. energy costs and some qualitative aspects e.g. energy service. The overall comparison of the considered energy systems for transportation service and combined heat and electricity application shows, that renewable hydrogen might be beneficial mainly for transportation services, if the electric vehicle will not be further developed to a feasibly wide-spread application for transportation service in future. For combined heat and electricity production there is no advantage of renewable hydrogen versus the direct use of renewable energy. Conclusions for Austria are therefore: 1) renewable hydrogen is an interesting energy carrier and might play an important role in a future sustainable Austrian energy system; 2) renewable hydrogen applications look most promising in the transportation sector; 3) renewable hydrogen applications will be of low importance for combined heat and electricity applications, as existing technologies for direct use of renewable energy for heat and electricity are well developed and very efficient; 4) In a future '100

  15. Self-renewal molecular mechanisms of colorectal cancer stem cells.

    Science.gov (United States)

    Pan, Tianhui; Xu, Jinghong; Zhu, Yongliang

    2017-01-01

    Colorectal cancer stem cells (CCSCs) represent a small fraction of the colorectal cancer cell population that possess self-renewal and multi-lineage differentiation potential and drive tumorigenicity. Self-renewal is essential for the malignant biological behaviors of colorectal cancer stem cells. While the self-renewal molecular mechanisms of colorectal cancer stem cells are not yet fully understood, the aberrant activation of signaling pathways, such as Wnt, Notch, transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) and Hedgehog-Gli (HH-GLI), specific roles mediated by cell surface markers and micro-environmental factors are involved in the regulation of self-renewal. The elucidation of the molecular mechanisms behind self-renewal may lead to the development of novel targeted interventions for the treatment of colorectal cancer.

  16. Special issue on advancing grid-connected renewable generation systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Yang, Yongheng

    2017-01-01

    Renewables are heavily involved in power generation, as an essential component for today’s energy paradigm. Energy structure—both national and international—has been undergoing significant changes over the past few decades. For instance, in Denmark, power generation is shifting from fossil......-fuel-based to renewable-based in terms of energy sources, from centralized to decentralized in terms of architectures, and from sole to miscellaneous in terms of energy varieties [1]. In this energy evolution, the power electronic technology plays an enabling role in the integration and advancements of renewables......—such as wind turbine, photovoltaics, fuel cells, and other emerging energy systems. At the same time, various control strategies are necessary to guide the energy integration (i.e., to enhance the energy transition), and on the other hand, to flexibly, reliably, and efficiently utilize the energy. Tremendous...

  17. Renewable energy

    International Nuclear Information System (INIS)

    Yoon, Cheon Seok

    2009-09-01

    This book tells of renewable energy giving description of environment problem, market of renewable energy and vision and economics of renewable energy. It also deals with solar light like solar cell, materials performance, system and merit of solar cell, solar thermal power such as solar cooker and solar collector, wind energy, geothermal energy, ocean energy like tidal power and ocean thermal energy conversion, fuel cell and biomass.

  18. Integrated electrofuels and renewable energy systems

    DEFF Research Database (Denmark)

    Ridjan, Iva

    energy into chemical energy by means of electrolysers, thus connecting fluctuating renewable energy to the vast amount of fuel storage already available in today’s energy systems. The conducted research indicates that electrofuels for heavy-duty transportation are technically and economically viable...... in energy systems and could play an important role in future energy systems. The cross-sector approach in the fuel production, by redirecting the excess electricity to the transport sector, is creating the flexibility and storage buffer for fluctuating electricity. The key concern in the short term should...

  19. Hydrogen, fuel cells and renewable energy integration in islands

    International Nuclear Information System (INIS)

    Bauen, A.; Hart, D.; Foradini, F.; Hart, D.

    2002-01-01

    Remote areas such as islands rely on costly and highly polluting diesel and heavy fuel oil for their electricity supply. This paper explored the opportunities for exploiting economically and environmentally viable renewable energy sources, in particular hydrogen storage, on such islands. In particular, this study focused on addressing the challenge of matching energy supply with demand and with technical issues regarding weak grids that are hindered with high steady state voltage levels and voltage fluctuations. The main technical characteristics of integrated renewable energy and hydrogen systems were determined by modelling a case study for the island of El Hierro (Canary Islands). The paper referred to the challenges regarding the technical and economic viability of such systems and their contribution to the economic development of remote communities. It was noted that energy storage plays an important role in addressing supply and demand issues by offering a way to control voltage and using surplus electricity at times of low load. Electrical energy can be stored in the form of potential or chemical energy. New decentralized generation technologies have also played a role in improving the energy efficiency of renewable energy sources. The feasibility of using hydrogen for energy storage was examined with particular reference to fuel-cell based energy supply in isolated island communities. 4 refs., 5 figs

  20. Policies for 100% Renewable Energy Systems

    DEFF Research Database (Denmark)

    Hvelplund, Frede

    2014-01-01

    The official Danish energy policy goal is both to increase the wind power share of electricity consumption from 33% in 2014 to 50% by 2020 and to have a 100% renewable energy based energy system by 2050. This is a huge technological change from stored, scarce and polluting fossil fuels...... to fluctuating, abundant and clean energy sources. “Stored” fossil fuels can be used when needed; fluctuating energy sources must be captured when available and transformed to meet the energy needs of society in the right amounts and at the right time. We are amidst this change. Renewable energy has come of age...... and is no longer a minor technology experimenting in the corner of the energy scene, but has become a large new technology taking away considerable market shares from the old fossil fuel technologies....

  1. The feasibility of synthetic fuels in renewable energy systems

    DEFF Research Database (Denmark)

    Ridjan, Iva; Mathiesen, Brian Vad; Connolly, D.

    2013-01-01

    , and other impacts on the environment and biosphere. Hence, it is essential to make a detailed analysis of this sector in order to match the demand and to meet the criteria of a 100% renewable energy system in 2050. The purpose of this article is to identify potential pathways for producing synthetic fuels......, with a specific focus on solid oxide electrolyser cells (SOEC) combined with the recycling of CO2....

  2. The feasibility of synthetic fuels in renewable energy systems

    DEFF Research Database (Denmark)

    Ridjan, Iva; Mathiesen, Brian Vad; Connolly, David

    2012-01-01

    supplies, and other impacts on environment and biosphere. Hence, it is essential to make a detailed analysis of this sector in order to match the demand and to meet the criteria of a 100% renewable energy system in 2050. The purpose of this article is to identify potential pathways for producing synthetic...... fuels, with a specific focus on solid oxide electrolyser cells combined with the recycling of CO2....

  3. The system architecture for renewable synthetic fuels

    DEFF Research Database (Denmark)

    Ridjan, Iva

    To overcome and eventually eliminate the existing heavy fossil fuels in the transport sector, there is a need for new renewable fuels. This transition could lead to large capital costs for implementing the new solutions and a long time frame for establishing the new infrastructure unless a suitable...... and production plants, so it is important to implement it in the best manner possible to ensure an efficient and flexible system. The poster will provide an overview of the steps involved in the production of synthetic fuel and possible solutions for the system architecture based on the current literature...

  4. Integrated transport and renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Nørgaard, P.

    2008-01-01

    No single technology can solve the problem of ever increasing CO2 emissions from transport. Here, a coherent effort to integrate transport into energyplanning is proposed, using multiple means promoting sustainable transport. It is concluded that a 100 per cent renewable energy transport system...... is possible but is connected to significant challenges in the path towards it. Biomass is a limited resource and it is important to avoid effecting the production of food. The integration of the transport with the energy system is crucial as is a multi-pronged strategy. Short term solutions have to consider...

  5. Renewal of cooling system of JMTR

    International Nuclear Information System (INIS)

    Onoue, Ryuji; Kawamata, Takanori; Otsuka, Kaoru; Koike, Sumio; Nishiyama, Yutaka; Fukasaku, Akitomi

    2011-06-01

    The Japan Materials Testing Reactor (JMTR) is a light water moderated and cooled tank-type reactor, and its thermal power is 50 MW. The JMTR is categorized as high flux testing reactors in the world. The JMTR has been utilized for irradiation experiments of nuclear fuels and materials, as well as for radioisotope productions since the first criticality in March 1968 until August 2006. JAEA decided to refurbish the JMTR as an important fundamental infrastructure to promote the nuclear research and development. The refurbishment work was started from 2007, and restart is planned in 2011. Renewal facilities were selected from evaluation on their damage and wear in terms of aging. Facilities whose replacement parts are no longer manufactured or not likely to be manufactured continuously in near future, are selected as renewal ones. Replacement priority was decided with special attention to safety concerns. A monitoring of aging condition by the regular maintenance activity is an important factor in selection of continuous using after the restart. In this report, renewal of the cooling system within refurbishment facilities in the JMTR is summarized. (author)

  6. The geopolitics of renewables; exploring the political implications of renewable energy systems

    NARCIS (Netherlands)

    Scholten, D.J.; Bosman, Rick

    2016-01-01

    This paper explores the potential political implications of the geographic and technical characteristics of renewable energy systems. This is done through a thought experiment that imagines a purely renewable based energy system, keeping all else equal. We start by noting that all countries have

  7. Renewable energy systems a smart energy systems approach to the choice and modeling of 100% renewable solutions

    CERN Document Server

    Lund, Henrik

    2014-01-01

    In this new edition of Renewable Energy Systems, globally recognized renewable energy researcher and professor, Henrik Lund, sets forth a straightforward, comprehensive methodology for comparing different energy systems' abilities to integrate fluctuating and intermittent renewable energy sources. The book does this by presenting an energy system analysis methodology and offering a freely available accompanying software tool, EnergyPLAN, which automates and simplifies the calculations supporting such a detailed comparative analysis. The book provides the results of more than fifteen comprehensive energy system analysis studies, examines the large-scale integration of renewable energy into the present system, and presents concrete design examples derived from a dozen renewable energy systems around the globe. Renewable Energy Systems, Second Edition also undertakes the socio-political realities governing the implementation of renewable energy systems by introducing a theoretical framework approach aimed at ...

  8. Optimization of Hybrid Renewable Energy Systems

    Science.gov (United States)

    Contreras Cordero, Francisco Jose

    Use of diesel generators in remote communities is economically and environmentally unsustainable. Consequently, researchers have focussed on designing hybrid renewable energy systems (HRES) for distributed electricity generation in remote communities. However, the cost-effectiveness of interconnecting multiple remote communities (microgrids) has not been explored. The main objective of this thesis is to develop a methodology for optimal design of HRES and microgrids for remote communities. A set of case studies was developed to test this methodology and it was determined that a combination of stand-alone decentralized HRES and microgrids is the most cost-effective power generation scheme when studying a group of remote communities.

  9. Future UK markets for stand-alone renewable energy systems

    International Nuclear Information System (INIS)

    Paish, O.

    1999-01-01

    A study to identify and quantify the market for stand-alone renewable energy supplies of power (photovoltaics, wind and micro-hydro electricity systems) was described. The study focused on small systems, generally less than a few kW installed capacity. It was suggested that in the UK, the emphasis on grid-connected renewable energy technologies (RETs) has blurred the fact that it is 'off-grid' renewable systems that can offer more immediate real commercial markets for the renewables business. With the likelihood of a significant increase in demand for renewables world wide over the next ten years, the UK needs to make a special effort to become involved

  10. The Ganil computer control system renewal

    International Nuclear Information System (INIS)

    David, L.; Lecorche, E.; Luong, T.T.; Ulrich, M.

    1990-01-01

    Since 1982 the GANIL heavy ion accelerator has been under the control of 16-bit minicomputers MITRA, programmable logic controllers and microprocessorized Camac controllers, structured into a partially centralized system. This control system has to be renewed to meet the increasing demands of the accelerator operation which aims to provide higher quality ion beams under more reliable conditions. This paper gives a brief description of the existing control system and then discusses the main issues of the design and the implementation of the future control system: distributed powerful processors federated through Ethernet and flexible network-wide database access, VME standard and front-end microprocessors, enhanced color graphic tools and workstation based operator interface

  11. Smart power systems and renewable energy system integration

    CERN Document Server

    2016-01-01

    This monograph presents a wider spectrum of researches, developments, and case specific studies in the area of smart power systems and integration of renewable energy systems. The book will be for the benefit of a wider audience including researchers, postgraduate students, practicing engineers, academics, and regulatory policy makers. It covers a wide range of topics from fundamentals, and modelling and simulation aspects of traditional and smart power systems to grid integration of renewables; Micro Grids; challenges in planning and operation of a smart power system; risks, security, and stability in smart operation of a power system; and applied research in energy storage. .

  12. Electric vehicles and renewable energy in the transport sector - energy system consequences. Main focus: Battery electric vehicles and hydrogen based fuel cell vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, L.H.; Joergensen, K.

    2000-04-01

    The aim of the project is to analyse energy, environmental and economic aspects of integrating electric vehicles in the future Danish energy system. Consequences of large-scale utilisation of electric vehicles are analysed. The aim is furthermore to illustrate the potential synergistic interplay between the utilisation of electric vehicles and large-scale utilisation of fluctuating renewable energy resources, such as wind power. Economic aspects for electric vehicles interacting with a liberalised electricity market are analysed. The project focuses on battery electric vehicles and fuel cell vehicles based on hydrogen. Based on assumptions on the future technical development for battery electric vehicles, fuel cell vehicles on hydrogen, and for the conventional internal combustion engine vehicles, scenarios are set up to reflect expected options for the long-term development of road transport vehicles. Focus is put on the Danish fleet of passenger cars and delivery vans. The scenario analysis includes assumptions on market potential developments and market penetration for the alternative vehicles. Vehicle replacement rates in the Danish transport fleet and the size of fleet development are based on data from The Danish Road Directorate. The electricity supply system development assumed is based on the Danish energy plan, Energy 21, The Plan scenario. The time horizon of the analysis is year 2030. Results from the scenario analysis include the time scales involved for the potential transition towards electricity based vehicles, the fleet composition development, the associated developments in transport fuel consumption and fuel substitution, and the potential CO{sub 2}-emission reduction achievable in the overall transport and power supply system. Detailed model simulations, on an hourly basis, have furthermore been carried out for year 2005 that address potential electricity purchase options for electric vehicles in the context of a liberalised electricity market

  13. Electric vehicles and renewable energy in the transport sector - energy system consequences. Main focus: Battery electric vehicles and hydrogen based fuel cell vehicles

    International Nuclear Information System (INIS)

    Nielsen, L.H.; Joergensen, K.

    2000-04-01

    The aim of the project is to analyse energy, environmental and economic aspects of integrating electric vehicles in the future Danish energy system. Consequences of large-scale utilisation of electric vehicles are analysed. The aim is furthermore to illustrate the potential synergistic interplay between the utilisation of electric vehicles and large-scale utilisation of fluctuating renewable energy resources, such as wind power. Economic aspects for electric vehicles interacting with a liberalised electricity market are analysed. The project focuses on battery electric vehicles and fuel cell vehicles based on hydrogen. Based on assumptions on the future technical development for battery electric vehicles, fuel cell vehicles on hydrogen, and for the conventional internal combustion engine vehicles, scenarios are set up to reflect expected options for the long-term development of road transport vehicles. Focus is put on the Danish fleet of passenger cars and delivery vans. The scenario analysis includes assumptions on market potential developments and market penetration for the alternative vehicles. Vehicle replacement rates in the Danish transport fleet and the size of fleet development are based on data from The Danish Road Directorate. The electricity supply system development assumed is based on the Danish energy plan, Energy 21, The Plan scenario. The time horizon of the analysis is year 2030. Results from the scenario analysis include the time scales involved for the potential transition towards electricity based vehicles, the fleet composition development, the associated developments in transport fuel consumption and fuel substitution, and the potential CO 2 -emission reduction achievable in the overall transport and power supply system. Detailed model simulations, on an hourly basis, have furthermore been carried out for year 2005 that address potential electricity purchase options for electric vehicles in the context of a liberalised electricity market. The

  14. Muscle satellite cell heterogeneity and self-renewal

    Science.gov (United States)

    Motohashi, Norio; Asakura, Atsushi

    2014-01-01

    Adult skeletal muscle possesses extraordinary regeneration capacities. After muscle injury or exercise, large numbers of newly formed muscle fibers are generated within a week as a result of expansion and differentiation of a self-renewing pool of muscle stem cells termed muscle satellite cells. Normally, satellite cells are mitotically quiescent and reside beneath the basal lamina of muscle fibers. Upon regeneration, satellite cells are activated, and give rise to daughter myogenic precursor cells. After several rounds of proliferation, these myogenic precursor cells contribute to the formation of new muscle fibers. During cell division, a minor population of myogenic precursor cells returns to quiescent satellite cells as a self-renewal process. Currently, accumulating evidence has revealed the essential roles of satellite cells in muscle regeneration and the regulatory mechanisms, while it still remains to be elucidated how satellite cell self-renewal is molecularly regulated and how satellite cells are important in aging and diseased muscle. The number of satellite cells is decreased due to the changing niche during ageing, resulting in attenuation of muscle regeneration capacity. Additionally, in Duchenne muscular dystrophy (DMD) patients, the loss of satellite cell regenerative capacity and decreased satellite cell number due to continuous needs for satellite cells lead to progressive muscle weakness with chronic degeneration. Thus, it is necessary to replenish muscle satellite cells continuously. This review outlines recent findings regarding satellite cell heterogeneity, asymmetric division and molecular mechanisms in satellite cell self-renewal which is crucial for maintenance of satellite cells as a muscle stem cell pool throughout life. In addition, we discuss roles in the stem cell niche for satellite cell maintenance, as well as related cell therapies for approaching treatment of DMD. PMID:25364710

  15. Muscle Satellite Cell Heterogeneity and Self-Renewal

    Directory of Open Access Journals (Sweden)

    Norio eMotohashi

    2014-01-01

    Full Text Available Adult skeletal muscle possesses extraordinary regeneration capacities. After muscle injury or exercise, large numbers of newly formed muscle fibers are generated within a week as a result of expansion and differentiation of a self-renewing pool of muscle stem cells termed muscle satellite cells. Normally, satellite cells are mitotically quiescent and reside beneath the basal lamina of muscle fibers. Upon regeneration, satellite cells are activated, and give rise to daughter myogenic precursor cells. After several rounds of proliferation, these myogenic precursor cells contribute to the formation of new muscle fibers. During cell division, a minor population of myogenic precursor cells returns to quiescent satellite cells as a self-renewal process. Currently, accumulating evidence has revealed the essential roles of satellite cells in muscle regeneration and the regulatory mechanisms, while it still remains to be elucidated how satellite cell self-renewal is molecularly regulated and how satellite cells are important in aging and diseased muscle. The number of satellite cells is decreased due to the changing niche during ageing, resulting in attenuation of muscle regeneration capacity. Additionally, in Duchenne muscular dystrophy (DMD patients, the loss of satellite cell regenerative capacity and decreased satellite cell number due to continuous needs for satellite cells lead to progressive muscle weakness with chronic degeneration. Thus, it is necessary to replenish muscle satellite cells continuously. This review outlines recent findings regarding satellite cell heterogeneity, asymmetric division and molecular mechanisms in satellite cell self-renewal which is crucial for maintenance of satellite cells as a muscle stem cell pool throughout life. In addition, we discuss roles in the stem cell niche for satellite cell maintenance, as well as related cell therapies for approaching treatment of DMD.

  16. Integration of Renewable Generation in Power System Defence Plans

    DEFF Research Database (Denmark)

    Das, Kaushik

    Increasing levels of penetration of wind power and other renewable generations in European power systems pose challenges to power system security. The power system operators are continuously challenged especially when generations from renewables are high thereby reducing online capacity of conven......Increasing levels of penetration of wind power and other renewable generations in European power systems pose challenges to power system security. The power system operators are continuously challenged especially when generations from renewables are high thereby reducing online capacity......, one of them being the North East area with high share of wind power generation.The aim of this study is to investigate how renewable generations like wind power can contribute to the power system defence plans. This PhD project “Integration of Renewable Generation in Power System Defence Plans...

  17. Hematopoietic stem cells : Self-renewing or aging?

    NARCIS (Netherlands)

    de Haan, G

    2002-01-01

    Stem cells are defined by their extensive self-renewal properties, and yet there is abundant evidence of erosion of stem cell functioning during aging. Whereas intracellular repair and protection mechanisms determine the lifespan of an individual cell, here an argument is made that somatic stem

  18. Solid Oxide Fuel Cells Operating on Alternative and Renewable Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiaoxing; Quan, Wenying; Xiao, Jing; Peduzzi, Emanuela; Fujii, Mamoru; Sun, Funxia; Shalaby, Cigdem; Li, Yan; Xie, Chao; Ma, Xiaoliang; Johnson, David; Lee, Jeong; Fedkin, Mark; LaBarbera, Mark; Das, Debanjan; Thompson, David; Lvov, Serguei; Song, Chunshan

    2014-09-30

    This DOE project at the Pennsylvania State University (Penn State) initially involved Siemens Energy, Inc. to (1) develop new fuel processing approaches for using selected alternative and renewable fuels – anaerobic digester gas (ADG) and commercial diesel fuel (with 15 ppm sulfur) – in solid oxide fuel cell (SOFC) power generation systems; and (2) conduct integrated fuel processor – SOFC system tests to evaluate the performance of the fuel processors and overall systems. Siemens Energy Inc. was to provide SOFC system to Penn State for testing. The Siemens work was carried out at Siemens Energy Inc. in Pittsburgh, PA. The unexpected restructuring in Siemens organization, however, led to the elimination of the Siemens Stationary Fuel Cell Division within the company. Unfortunately, this led to the Siemens subcontract with Penn State ending on September 23rd, 2010. SOFC system was never delivered to Penn State. With the assistance of NETL project manager, the Penn State team has since developed a collaborative research with Delphi as the new subcontractor and this work involved the testing of a stack of planar solid oxide fuel cells from Delphi.

  19. Identifying The Most Applicable Renewable Energy Systems Of Iran

    Directory of Open Access Journals (Sweden)

    Nasibeh Mousavi

    2017-03-01

    Full Text Available These years because of energy crisis all of country try to find a new way to reduce energy consumptions and obtain maximum use of renewable energy. Iran also is not an exception of this progress. Renewable energy is energy that is provided by renewable sources such as the sun or wind. In general renewable energies are not adaptable to every single community. Because of location and special climate conditions of Iran most applicable renewable energy systems in Iran are solar and wind energy. Main purpose of this paper is to review and identify most applicable renewable energy systems of Iran and also review on traditional and current methods that utilized to obtain maximum use of these renewable energies.

  20. Input-output analysis for installing renewable energy systems

    International Nuclear Information System (INIS)

    Itoh, Y.; Nakata, T.

    2004-01-01

    Renewable energy facilities have been installed in many regions, because of their possibility to be an alternative to fossil fuels for mitigating global warming. Besides the profitability of renewable energy businesses, indirect economic effects of installing renewable energy facilities should be clarified. This study examines the possibility that the renewable energy facilities give renewed impetus to regional economic progress. The economic effects are analysed with input-output techniques in a rural area in Japan. As a consequence, both positive and negative effects on the rural economy are derived. In addition, we will focus on the changes in sectors such as construction, business services, banking, etc. as a result of economic activities for renewable systems. The business benefits of renewable energy system are discussed. (author)

  1. Energy System Analysis of 100 Per cent Renewable Energy Systems

    DEFF Research Database (Denmark)

    Lund, Henrik; Mathiesen, Brian Vad

    2007-01-01

    This paper presents the methodology and results of the overall energy system analysis of a 100 per cent renewable energy system. The input for the systems is the result of a project of the Danish Association of Engineers, in which 1600 participants during more than 40 seminars discussed...... and designed a model for the future energy system of Denmark, putting emphasis on energy efficiency, CO2 reduction, and industrial development. The energy system analysis methodology includes hour by hour computer simulations leading to the design of flexible energy systems with the ability to balance...... the electricity supply and demand and to exchange electricity productions on the international electricity markets. The results are detailed system designs and energy balances for two energy target years: year 2050 with 100 per cent renewable energy from biomass and combinations of wind, wave and solar power...

  2. Renewable energy systems the choice and modeling of 100% renewable solutions

    CERN Document Server

    Lund, Henrik

    2009-01-01

    How can society quickly convert to renewable energy? Can worldwide energy needs ever be met through 100% renewable sources? The answers to these questions rest largely on the perception of choice in the energy arena. It is of pivotal importance that engineers, researchers and policymakers understand what choices are available, and reasonable, when considering the design and deployment of new energy systems. The mission of this new book, written by one of the world's foremost experts in renewable power, is to arm these professionals with the tools and methodologies necessary to make smart choic

  3. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation.

    Science.gov (United States)

    Wang, Kui; Zhang, Tao; Dong, Qiang; Nice, Edouard Collins; Huang, Canhua; Wei, Yuquan

    2013-03-14

    Stem cells are characterized by their unique ability of self-renewal to maintain the so-called stem cell pool. Over the past decades, reactive oxygen species (ROS) have been recognized as toxic aerobic metabolism byproducts that are harmful to stem cells, leading to DNA damage, senescence or cell death. Recently, a growing body of literature has shown that stem cells reside in redox niches with low ROS levels. The balance of Redox homeostasis facilitates stem cell self-renewal by an intricate network. Thus, to fully decipher the underlying molecular mechanisms involved in the maintenance of stem cell self-renewal, it is critical to address the important role of redox homeostasis in the regulation of self-renewal and differentiation of stem cells. In this regard, we will discuss the regulatory mechanisms involved in the subtly orchestrated balance of redox status in stem cells by scavenger antioxidant enzyme systems that are well monitored by the hypoxia niches and crucial redox regulators including forkhead homeobox type O family (FoxOs), apurinic/apyrimidinic (AP) endonuclease1/redox factor-1 (APE1/Ref-1), nuclear factor erythroid-2-related factor 2 (Nrf2) and ataxia telangiectasia mutated (ATM). We will also introduce several pivotal ROS-sensitive molecules, such as hypoxia-inducible factors, p38 mitogen-activated protein kinase (p38) and p53, involved in the redox-regulated stem cell self-renewal. Specifically, all the aforementioned molecules can act as 'redox sensors' by virtue of redox modifications of their cysteine residues, which are critically important in the control of protein function. Given the importance of redox homeostasis in the regulation of stem cell self-renewal, understanding the underlying molecular mechanisms involved will provide important new insights into stem cell biology.

  4. Resveratrol Enhances Self-Renewal of Mouse Embryonic Stem Cells.

    Science.gov (United States)

    Li, Na; Du, Zhaoyu; Shen, Qiaoyan; Lei, Qijing; Zhang, Ying; Zhang, Mengfei; Hua, Jinlian

    2017-07-01

    Resveratrol (RSV) has been shown to affect the differentiation of several types of stem cells, while the detailed mechanism is elusive. Here, we aim to investigate the function of RSV in self-renewal of mouse embryonic stem cells (ESCs) and the related mechanisms. In contrast with its reported roles, we found unexpectedly that differentiated ESCs or iPSCs treated by RSV would not show further differentiation, but regained a naïve pluripotency state with higher expressions of core transcriptional factors and with the ability to differentiate into all three germ layers when transplanted in vivo. In accordance with these findings, RSV also enhanced cell cycle progression of ESCs via regulating cell cycle-related proteins. Finally, enhanced activation of JAK/STAT3 signaling pathway and suppressed activation of mTOR were found essential in enhancing the self-renewal of ESCs by RSV. Our finding discovered a novel function of RSV in enhancing the self-renewal of ESCs, and suggested that the timing of treatment and concentration of RSV determined the final effect of it. Our work may contribute to understanding of RSV in the self-renewal maintenance of pluripotent stem cells, and may also provide help to the generation and maintenance of iPSCs in vitro. J. Cell. Biochem. 118: 1928-1935, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  5. Cell-type-specific predictive network yields novel insights into mouse embryonic stem cell self-renewal and cell fate.

    Directory of Open Access Journals (Sweden)

    Karen G Dowell

    Full Text Available Self-renewal, the ability of a stem cell to divide repeatedly while maintaining an undifferentiated state, is a defining characteristic of all stem cells. Here, we clarify the molecular foundations of mouse embryonic stem cell (mESC self-renewal by applying a proven Bayesian network machine learning approach to integrate high-throughput data for protein function discovery. By focusing on a single stem-cell system, at a specific developmental stage, within the context of well-defined biological processes known to be active in that cell type, we produce a consensus predictive network that reflects biological reality more closely than those made by prior efforts using more generalized, context-independent methods. In addition, we show how machine learning efforts may be misled if the tissue specific role of mammalian proteins is not defined in the training set and circumscribed in the evidential data. For this study, we assembled an extensive compendium of mESC data: ∼2.2 million data points, collected from 60 different studies, under 992 conditions. We then integrated these data into a consensus mESC functional relationship network focused on biological processes associated with embryonic stem cell self-renewal and cell fate determination. Computational evaluations, literature validation, and analyses of predicted functional linkages show that our results are highly accurate and biologically relevant. Our mESC network predicts many novel players involved in self-renewal and serves as the foundation for future pluripotent stem cell studies. This network can be used by stem cell researchers (at http://StemSight.org to explore hypotheses about gene function in the context of self-renewal and to prioritize genes of interest for experimental validation.

  6. Renewable energy integration into the Spanish power system

    International Nuclear Information System (INIS)

    Duvison Garcia, Miguel R.; Rivas Cuenca, Ana

    2013-01-01

    The increase in renewable energy sources in the Spanish peninsular system, along with the installation of other technologies represents a challenge due to the particularities of this type of technologies. Innovative solutions and new operation paradigms may be needed in order to cope with these challenges. Grid codes must incorporate new specifications for these technologies and demand management strategies must be incorporated in control centers in order to balance the system, maximize renewable production and maintain system security. In real time, the most significant improvements that ease integration of renewable resources are the introduction of observability and controllability, which is especially important in dealing with the problem of system balancing and the impact of renewable energy on matching generation and demand. In this regard the commissioning of a control center specifically for management of these technologies have been taken in the Spanish electrical system in order to integrate the maximum amount of renewable energy

  7. Internet Renewable energy Information System (IRIS)

    DEFF Research Database (Denmark)

    Bäurle, Britta; Nielsen, Vilhjalmur; Ménard, Lionel

    1999-01-01

    Even though the Internet is now a widely accessible data source, the unorganised flood of information makes a specific request e.g. for renewable energy products inefficient. In addition, existing databases on renewable energies are often old and incomplete. The objective of IRIS has been...... to organise and retrieve renewable energy product information on the Internet instead of collecting it manually. Updating coincides with the self interestself-interest of manufacturers to present their latest renewable energy products on their own HTML documents. IRIS is based on a set of powerful tools...... and intends to find, extract, collect and index HTML documents with standardised META tags that are widely spread across web servers on the Internet. This paper presents the structure of IRIS, the software tools, and gives one example of how to categorise and prepare web-sites with product information...

  8. Porcine spermatogonial stem cells self-renew effectively in a three dimensional culture microenvironment.

    Science.gov (United States)

    Park, Ji Eun; Park, Min Hee; Kim, Min Seong; Park, Yeo Reum; Yun, Jung Im; Cheong, Hee Tae; Kim, Minseok; Choi, Jung Hoon; Lee, Eunsong; Lee, Seung Tae

    2017-12-01

    Generally, self-renewal of spermatogonial stem cells (SSCs) is maintained in vivo in a three-dimensional (3D) microenvironment consisting of the seminiferous tubule basement membrane, indicating the importance of the 3D microenvironment for in vitro culture of SSCs. Here, we report a 3D culture microenvironment that effectively maintains porcine SSC self-renewal during culture. Porcine SSCs were cultured in an agarose-based 3D hydrogel and in 2D culture plates either with or without feeder cells. Subsequently, the effects of 3D culture on the maintenance of undifferentiated SSCs were identified by analyzing cell colony formation and morphology, AP activity, and transcriptional and translational regulation of self-renewal-related genes and the effects on proliferation by analyzing cell viability and single cell-derived colony number. The 3D culture microenvironment constructed using a 0.2% (w/v) agarose-based 3D hydrogel showed the strongest maintenance of porcine SSC self-renewal and induced significant improvements in proliferation compared with 2D culture microenvironments. These results demonstrate that self-renewal of porcine SSCs can be maintained more effectively in a 3D than in a 2D culture microenvironment. Moreover, this will play a significant role in developing novel culture systems for SSCs derived from diverse species in the future, which will contribute to SSC-related research. © 2017 International Federation for Cell Biology.

  9. Mid-term report on Renewable Energy Forecasting System

    International Nuclear Information System (INIS)

    Brand, A.J.; Hegberg, T.; Van der Borg, N.J.C.M.; Kok, J.K.; Van Selow, E.R.; Kamphuis, I.G.; De Noord, M.; Van Sambeek, E.J.W.

    2001-04-01

    The most important conclusions on the economical and technical feasibility of renewable energy forecasting systems are presented, next to recommendations to be followed in order to introduce such a system in the Dutch electricity market. 11 refs

  10. Renewable energy systems advanced conversion technologies and applications

    CERN Document Server

    Luo, Fang Lin

    2012-01-01

    Energy conversion techniques are key in power electronics and even more so in renewable energy source systems, which require a large number of converters. Renewable Energy Systems: Advanced Conversion Technologies and Applications describes advanced conversion technologies and provides design examples of converters and inverters for renewable energy systems-including wind turbine and solar panel energy systems. Learn Cutting-Edge Techniques for Converters and Inverters Setting the scene, the book begins with a review of the basics of astronomy and Earth physics. It then systematically introduc

  11. Life-cycle analysis of renewable energy systems

    DEFF Research Database (Denmark)

    Sørensen, Bent

    1994-01-01

    An imlementation of life-cycle analysis (LCA) for energy systems is presented and applied to two renewable energy systems (wind turbines and building-integrated photovoltaic modules) and compared with coal plants......An imlementation of life-cycle analysis (LCA) for energy systems is presented and applied to two renewable energy systems (wind turbines and building-integrated photovoltaic modules) and compared with coal plants...

  12. Renewable energy systems in Mexico: Installation of a hybrid system

    Science.gov (United States)

    Pate, Ronald C.

    1993-05-01

    Sandia has been providing technical leadership on behalf of DOE and CORECT on a working level cooperative program with Mexico on renewable energy (PROCER). As part of this effort, the Sandia Design Assistance Center (DAC) and the solar energy program staff at Instituto de Investigaciones Electricas (IIE) in Cuernavaca, Mexico, recently reached agreement on a framework for mutually beneficial technical collaboration on the monitoring and field evaluation of renewable energy systems in Mexico, particularly village-scale hybrid systems. This trip was made for the purpose of planning the details for the joint installation of a data acquisition system (DAS) on a recently completed PV/Wind/Diesel hybrid system in the village of Xcalac on the Southeast coast of the state of Quintana Roo, Mexico. The DAS installation will be made during the week of March 15, 1993. While in Mexico, discussions were also held with personnel from.the National Autonomous University of Mexico (UNAM) Solar Energy Laboratory and several private sector companies with regard to renewable energy project activities and technical and educational support needs in Mexico.

  13. Limiting biomass consumption for heating in 100% renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Connolly, David

    2012-01-01

    -scale solar thermal, large heat pumps, geothermal heat, industrial surplus heat, and waste incineration. Where the energy density in the building stock is not high enough for DH to be economical, geothermal heat pumps can be recommended for individual heating systems, even though biomass consumption is higher......The utilisation of biomass poses large challenges in renewable energy systems while buildings account for a substantial part of the energy supply even in 100% renewable energy systems. In this paper the focus is on how the heating sector can reduce its consumption of biomass, thus leaving biomass...... for other sectors, but while still enabling a 100% renewable energy system. The analyses of heating technologies shows that district heating (DH) systems are important in limiting the dependence on biomass and create cost effective solutions. DH systems are especially important in renewable energy systems...

  14. Metabolic rate determines haematopoietic stem cell self-renewal.

    Science.gov (United States)

    Sastry, P S R K

    2004-01-01

    The number of haematopoietic stem cells (HSCs) per animal is conserved across species. This means the HSCs need to maintain hematopoiesis over a longer period in larger animals. This would result in the requirement of stem cell self-renewal. At present the three existing models are the stochastic model, instructive model and the third more recently proposed is the chiaro-scuro model. It is a well known allometric law that metabolic rate scales to the three quarter power. Larger animals have a lower metabolic rate, compared to smaller animals. Here it is being hypothesized that metabolic rate determines haematopoietic stem cell self-renewal. At lower metabolic rate the stem cells commit for self-renewal, where as at higher metabolic rate they become committed to different lineages. The present hypothesis can explain the salient features of the different models. Recent findings regarding stem cell self-renewal suggest an important role for Wnt proteins and their receptors known as frizzleds, which are an important component of cell signaling pathway. The role of cGMP in the Wnts action provides further justification for the present hypothesis as cGMP is intricately linked to metabolic rate. One can also explain the telomere homeostasis by the present hypothesis. One prediction of the present hypothesis is with reference to the limit of cell divisions known as Hayflick limit, here it is being suggested that this is the result of metabolic rate in laboratory conditions and there can be higher number of cell divisions in vivo if the metabolic rate is lower. Copyright 2004 Elsevier Ltd.

  15. Smart grid and renewable energy systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Guerrero, Josep M.

    2011-01-01

    conventional, fossil based energy sources to renewable energy sources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discus trends of the future grid infrastructure as well as the most emerging renewable energy...... as efficient as possible. Further, the recent challenges with nuclear power plants are arguing to find more sustainable energy generation solutions. Of many options, two major technologies will play important roles to solve parts of those future challenges. One is to change the electrical power production from...... sources, wind energy and photovoltaics. Then main focus is on the power electronics and control technology for wind turbines as they are the largest renewable power contributor, allowing their penetration into a SmartGrid to be even higher in the future....

  16. Response of Non-Linear Systems to Renewal Impulses by Path Integration

    DEFF Research Database (Denmark)

    Nielsen, Søren R.K.; Iwankiewicz, R.

    The cell-to-cell mapping (path integration) technique has been devised for MDOF non-linear and non-hysteretic systems subjected to random trains of impulses driven by an ordinary renewal point process with gamma-distributed integer parameter interarrival times (an Erlang process). Since the renewal...... point process has not independent increments the state vector of the system, consisting of the generalized displacements and velocities, is not a Markov process. Initially it is shown how the indicated systems can be converted to an equivalent Poisson driven system at the expense of introducing...... additional discrete-valued state variables for which the stochastic equations are also formulated....

  17. The role of district heating in future renewable energy systems

    DEFF Research Database (Denmark)

    Lund, Henrik; Möller, Bernd; Mathiesen, Brian Vad

    2010-01-01

    Based on the case of Denmark, this paper analyses the role of district heating in future Renewable Energy Systems. At present, the share of renewable energy is coming close to 20 per cent. From such point of departure, the paper defines a scenario framework in which the Danish system is converted...... to 100 per cent Renewable Energy Sources (RES) in the year 2060 including reductions in space heating demands by 75 per cent. By use of a detailed energy system analysis of the complete national energy system, the consequences in relation to fuel demand, CO2 emissions and cost are calculated for various...... as in a potential future system based 100 per cent on renewable energy....

  18. CrxOS maintains the self-renewal capacity of murine embryonic stem cells

    International Nuclear Information System (INIS)

    Saito, Ryota; Yamasaki, Tokiwa; Nagai, Yoko; Wu, Jinzhan; Kajiho, Hiroaki; Yokoi, Tadashi; Noda, Eiichiro; Nishina, Sachiko; Niwa, Hitoshi; Azuma, Noriyuki; Katada, Toshiaki; Nishina, Hiroshi

    2009-01-01

    Embryonic stem (ES) cells maintain pluripotency by self-renewal. Several homeoproteins, including Oct3/4 and Nanog, are known to be key factors in maintaining the self-renewal capacity of ES cells. However, other genes required for the mechanisms underlying this process are still unclear. Here we report the identification by in silico analysis of a homeobox-containing gene, CrxOS, that is specifically expressed in murine ES cells and is essential for their self-renewal. ES cells mainly express the short isoform of endogenous CrxOS. Using a polyoma-based episomal expression system, we demonstrate that overexpression of the CrxOS short isoform is sufficient for maintaining the undifferentiated morphology of ES cells and stimulating their proliferation. Finally, using RNA interference, we show that CrxOS is essential for the self-renewal of ES cells, and provisionally identify foxD3 as a downstream target gene of CrxOS. To our knowledge, ours is the first delineation of the physiological role of CrxOS in ES cells.

  19. Fuel cell electric vehicle as a power plant : Fully renewable integrated transport and energy system design and analysis for smart city areas

    NARCIS (Netherlands)

    Oldenbroek, V.D.W.M.; Verhoef, L.A.; van Wijk, A.J.M.

    2017-01-01

    Reliable and affordable future zero emission power, heat and transport systems require efficient and versatile energy storage and distribution systems. This paper answers the question whether for city areas, solar and wind electricity together with fuel cell electric vehicles as energy generators

  20. Soft computing in green and renewable energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Gopalakrishnan, Kasthurirangan [Iowa State Univ., Ames, IA (United States). Iowa Bioeconomy Inst.; US Department of Energy, Ames, IA (United States). Ames Lab; Kalogirou, Soteris [Cyprus Univ. of Technology, Limassol (Cyprus). Dept. of Mechanical Engineering and Materials Sciences and Engineering; Khaitan, Siddhartha Kumar (eds.) [Iowa State Univ. of Science and Technology, Ames, IA (United States). Dept. of Electrical Engineering and Computer Engineering

    2011-07-01

    Soft Computing in Green and Renewable Energy Systems provides a practical introduction to the application of soft computing techniques and hybrid intelligent systems for designing, modeling, characterizing, optimizing, forecasting, and performance prediction of green and renewable energy systems. Research is proceeding at jet speed on renewable energy (energy derived from natural resources such as sunlight, wind, tides, rain, geothermal heat, biomass, hydrogen, etc.) as policy makers, researchers, economists, and world agencies have joined forces in finding alternative sustainable energy solutions to current critical environmental, economic, and social issues. The innovative models, environmentally benign processes, data analytics, etc. employed in renewable energy systems are computationally-intensive, non-linear and complex as well as involve a high degree of uncertainty. Soft computing technologies, such as fuzzy sets and systems, neural science and systems, evolutionary algorithms and genetic programming, and machine learning, are ideal in handling the noise, imprecision, and uncertainty in the data, and yet achieve robust, low-cost solutions. As a result, intelligent and soft computing paradigms are finding increasing applications in the study of renewable energy systems. Researchers, practitioners, undergraduate and graduate students engaged in the study of renewable energy systems will find this book very useful. (orig.)

  1. Renewable sustainable biocatalyzed electricity production in a photosynthetic algal microbial fuel cell (PAMFC)

    NARCIS (Netherlands)

    Strik, D.P.B.T.B.; Terlouw, H.; Hamelers, H.V.M.; Buisman, C.J.N.

    2008-01-01

    Electricity production via solar energy capturing by living higher plants and microalgae in combination with microbial fuel cells are attractive because these systems promise to generate useful energy in a renewable, sustainable, and efficient manner. This study describes the proof of principle of a

  2. Integrated Nuclear-Renewable Energy Systems: Foundational Workshop Report

    International Nuclear Information System (INIS)

    2014-01-01

    The U.S. Department of Energy (DOE) recognizes the need to transform the energy infrastructure of the U.S. and elsewhere to systems that can drastically reduce environmental impacts in an efficient and economically viable manner while utilizing both hydrocarbon resources and clean energy generation sources. Thus, DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options. A concept being advanced by the DOE Offices of Nuclear Energy (NE) and Energy Efficiency and Renewable Energy (EERE) is tighter coupling of nuclear and renewable energy sources in a manner that produces new energy currency for the combined electricity grid, industrial manufacturing, and the transportation energy sectors. This integration concept has been referred to as a ''hybrid system'' that is capable of providing the right type of energy, at the right time, in the right place. At the direction of DOE-NE and DOE-EERE leadership, project leads at Idaho National Laboratory (INL), National Renewable Energy Laboratory (NREL) and Massachusetts Institute of Technology (MIT) have identified and engaged stakeholders in discussing integrated energy systems that would optimize renewable and nuclear energy integration on a region-by-region basis. Subsequent work will entail conduct of technical, economic, environmental and socio-political evaluations of the leading integrated system options based on a set of criteria established with stakeholder input. The Foundational Workshop for Integrated Nuclear - Renewable Energy Systems was organized around the following objectives: 1. Identify and refine priority region-specific opportunities for integrated nuclear-renewable energy systems in the U.S.; 2. Select Figures of Merit (FOM) to rank and prioritize candidate systems; 3. Discuss enabling technology development needs; 4. Identify analysis requirements, capabilities and gaps to

  3. Integrated Nuclear-Renewable Energy Systems: Foundational Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Bragg-Sitton, Shannon [Idaho National Lab. (INL), Idaho Falls, ID (United States); Boardman, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ruth, Mark [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zinaman, Owen [National Renewable Energy Lab. (NREL), Golden, CO (United States); Forsberg, Charles [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Collins, John [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-08-01

    The U.S. Department of Energy (DOE) recognizes the need to transform the energy infrastructure of the U.S. and elsewhere to systems that can drastically reduce environmental impacts in an efficient and economically viable manner while utilizing both hydrocarbon resources and clean energy generation sources. Thus, DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options. A concept being advanced by the DOE Offices of Nuclear Energy (NE) and Energy Efficiency and Renewable Energy (EERE) is tighter coupling of nuclear and renewable energy sources in a manner that produces new energy currency for the combined electricity grid, industrial manufacturing, and the transportation energy sectors. This integration concept has been referred to as a “hybrid system” that is capable of providing the right type of energy, at the right time, in the right place. At the direction of DOE-NE and DOE-EERE leadership, project leads at Idaho National Laboratory (INL), National Renewable Energy Laboratory (NREL) and Massachusetts Institute of Technology (MIT) have identified and engaged stakeholders in discussing integrated energy systems that would optimize renewable and nuclear energy integration on a region-by-region basis. Subsequent work will entail conduct of technical, economic, environmental and socio-political evaluations of the leading integrated system options based on a set of criteria established with stakeholder input. The Foundational Workshop for Integrated Nuclear – Renewable Energy Systems was organized around the following objectives: 1. Identify and refine priority region-specific opportunities for integrated nuclear-renewable energy systems in the U.S.; 2. Select Figures of Merit (FOM) to rank and prioritize candidate systems; 3. Discuss enabling technology development needs; 4. Identify analysis requirements, capabilities and gaps to estimate FOM for

  4. Exploration of renewable sources for isolated systems

    OpenAIRE

    Apolo, Cristhian Agustin Apolo

    2017-01-01

    Providing universal access to electricity is a priority worldwide. Renewable Energy Sources (RES) play an important role in the supply of energy to rural and remote areas, where grid electricity is not available, or the cost of the grid extension is excessively. Isolated communities in the Amazon region of Ecuador are frequently far away from each other, formed by scattered housing, exhibit very low population density, and are surrounded by dense vegetation. Supplying such communities is typi...

  5. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation

    DEFF Research Database (Denmark)

    Klauke, Karin; Radulović, Višnja; Broekhuis, Mathilde

    2013-01-01

    The balance between self-renewal and differentiation of adult stem cells is essential for tissue homeostasis. Here we show that in the haematopoietic system this process is governed by polycomb chromobox (Cbx) proteins. Cbx7 is specifically expressed in haematopoietic stem cells (HSCs), and its...... overexpression enhances self-renewal and induces leukaemia. This effect is dependent on integration into polycomb repressive complex-1 (PRC1) and requires H3K27me3 binding. In contrast, overexpression of Cbx2, Cbx4 or Cbx8 results in differentiation and exhaustion of HSCs. ChIP-sequencing analysis shows that Cbx......7 and Cbx8 share most of their targets; we identified approximately 200 differential targets. Whereas genes targeted by Cbx8 are highly expressed in HSCs and become repressed in progenitors, Cbx7 targets show the opposite expression pattern. Thus, Cbx7 preserves HSC self-renewal by repressing...

  6. Power Electronics for Renewable Energy Systems - Status and Trends

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Ma, Ke; Yang, Yongheng

    2014-01-01

    electronics in generation, transmission/distribution and end-user application, together with advanced controls, can pave the way for renewable energy resources. In view of this, some of the most promising renewable candidates like wind power and photovoltaic, which are becoming a significant part...... in the electricity production, are explored in this paper. Issues like technology demands, power converter topologies, and control structures are addressed. Some special focuses are also paid on the emerging trends in power electronics development for those systems....

  7. International Conference on Power Electronics and Renewable Energy Systems

    CERN Document Server

    Suresh, L; Dash, Subhransu; Panigrahi, Bijaya

    2015-01-01

    The book is a collection of high-quality peer-reviewed research papers presented in Proceedings of International Conference on Power Electronics and Renewable Energy Systems (ICPERES 2014) held at Rajalakshmi Engineering College, Chennai, India. These research papers provide the latest developments in the broad area of Power Electronics and Renewable Energy. The book discusses wide variety of industrial, engineering and scientific applications of the emerging techniques. It presents invited papers from the inventors/originators of new applications and advanced technologies.

  8. Economic dispatch optimization for system integrating renewable energy sources

    Science.gov (United States)

    Jihane, Kartite; Mohamed, Cherkaoui

    2018-05-01

    Nowadays, the use of energy is growing especially in transportation and electricity industries. However this energy is based on conventional sources which pollute the environment. Multi-source system is seen as the best solution to sustainable development. This paper proposes the Economic Dispatch (ED) of hybrid renewable power system. The hybrid system is composed of ten thermal generators, photovoltaic (PV) generator and wind turbine generator. To show the importance of renewable energy sources (RES) in the energy mix we have ran the simulation for system integrated PV only and PV plus wind. The result shows that the system with renewable energy sources (RES) is more compromising than the system without RES in terms of fuel cost.

  9. Model Scaling of Hydrokinetic Ocean Renewable Energy Systems

    Science.gov (United States)

    von Ellenrieder, Karl; Valentine, William

    2013-11-01

    Numerical simulations are performed to validate a non-dimensional dynamic scaling procedure that can be applied to subsurface and deeply moored systems, such as hydrokinetic ocean renewable energy devices. The prototype systems are moored in water 400 m deep and include: subsurface spherical buoys moored in a shear current and excited by waves; an ocean current turbine excited by waves; and a deeply submerged spherical buoy in a shear current excited by strong current fluctuations. The corresponding model systems, which are scaled based on relative water depths of 10 m and 40 m, are also studied. For each case examined, the response of the model system closely matches the scaled response of the corresponding full-sized prototype system. The results suggest that laboratory-scale testing of complete ocean current renewable energy systems moored in a current is possible. This work was supported by the U.S. Southeast National Marine Renewable Energy Center (SNMREC).

  10. Management of a power system based on renewable energy

    Directory of Open Access Journals (Sweden)

    Ronay Karoly

    2012-06-01

    Full Text Available This article main purpose is to highlight the main advantage of the hardware and software implementation for an energy management system based on renewable energy sources. By using implemented and dedicated hardware and software the evolution of energy production and consumption can be monitored. The advantages of such system are highlighted by the results obtained from experimental simulations. An experimental model for the power system based on renewable energy sources was implemented, where the actual status of the system in different situations when the equipments change their own statuses can be shown.

  11. Impacts of intermittent renewable generation on electricity system costs

    International Nuclear Information System (INIS)

    Batalla-Bejerano, Joan; Trujillo-Baute, Elisa

    2016-01-01

    A successful deployment of power generation coming from variable renewable sources, such as wind and solar photovoltaic, strongly depends on the economic cost of system integration. This paper, in seeking to look beyond the impact of renewable generation on the evolution of the total economic costs associated with the operation of the electricity system, aims to estimate the sensitivity of balancing market requirements and costs to the variable and non-fully predictable nature of intermittent renewable generation. The estimations reported in this paper for the Spanish electricity system stress the importance of both attributes as well as power system flexibility when accounting for the cost of balancing services. - Highlights: •A successful deployment of VRES-E strongly depends on the economic cost of its integration. •We estimate the sensitivity of balancing market requirements and costs to VRES-E. •Integration costs depend on variability, predictability and system flexibility.

  12. Simulation of hybrid renewable microgeneration systems for variable electricity prices

    International Nuclear Information System (INIS)

    Brandoni, C.; Renzi, M.; Caresana, F.; Polonara, F.

    2014-01-01

    This paper addresses a hybrid renewable system that consists of a micro-Combined Cooling Heat and Power (CCHP) unit and a solar energy conversion device. In addition to a traditional PV system, a High Concentrator Photovoltaic (HCPV) device, the design of which is suitable for building integration application, was also modelled and embedded in the hybrid system. The work identifies the optimal management strategies for the hybrid renewable system in an effort to minimise the primary energy usage, the carbon dioxide emissions and the operational costs for variable electricity prices that result from the day-ahead electricity market. An “ad hoc” model describes the performance of the HCPV module, PV and Internal Combustion Engine, whilst the other units were simulated based on their main characteristic parameters. The developed algorithm was applied to three different building typologies. The results indicate that the best configuration is the hybrid renewable system with PV, which can provide a yearly primary energy reduction of between 20% and 30% compared to separate production. The hybrid renewable system with HCPV becomes competitive with the PV technology when the level of solar radiation is high. - Highlights: • The paper addresses a hybrid renewable system that consists of a micro-CCHP unit and a solar energy conversion device. • Both PV and High Concentrator Photovoltaic (HCPV) systems have been modelled and embedded in the hybrid system. • The work identifies the optimal management strategies for variable electricity prices. • Hybrid renewable systems provide a yearly primary energy reduction of between 20% and 30% compared to separate production. • When the level of solar radiation is high, HCPV becomes competitive with the PV technology

  13. 100% Renewable energy systems, climate mitigation and economic growth

    DEFF Research Database (Denmark)

    Vad Mathiesen, Brian; Lund, Henrik; Karlsson, Kenneth Bernard

    2011-01-01

    that implementing energy savings, renewable energy and more efficient conversion technologies can have positive socio-economic effects, create employment and potentially lead to large earnings on exports. If externalities such as health effects are included, even more benefits can be expected. 100% Renewable energy......Greenhouse gas mitigation strategies are generally considered costly with world leaders often engaging in debate concerning the costs of mitigation and the distribution of these costs between different countries. In this paper, the analyses and results of the design of a 100% renewable energy...... system by the year 2050 are presented for a complete energy system including transport. Two short-term transition target years in the process towards this goal are analysed for 2015 and 2030. The energy systems are analysed and designed with hour-by-hour energy system analyses. The analyses reveal...

  14. Adhesion-mediated self-renewal abilities of Ph+ blastoma cells

    International Nuclear Information System (INIS)

    Funayama, Keiji; Saito-Kurimoto, Yumi; Ebihara, Yasuhiro; Shimane, Miyuki; Nomura, Hitoshi; Tsuji, Ko-ichiro; Asano, Shigetaka

    2010-01-01

    The Philadelphia chromosome-positive blastoma, maintained by serial subcutaneous transplantation in nude mice, is a highly proliferating biological mass consisting of homogenous CD34 + CD38 - myeloblastoid cells. These cells newly evolved from pluripotent leukemia stem cells of chronic myeloid leukemia in the chronic phase. Therefore, this mass may provide a unique tool for better understanding cellular and molecular mechanisms of self-renewal of leukemia stem cells. In this paper, we demonstrated that intravenously injected blastoma cells can cause Ph+ blastic leukemia with multiple invasive foci in NOD/SCID mice but not in nude mice. In addition, using an in vitro culture system, we clearly showed that blastoma cell adhesion to OP9 stromal cells accelerates blastoma cell proliferation that is associated with up-regulation of BMI1 gene expression; increased levels of β-catenin and the Notch1 intra-cellular domain; and changed the expression pattern of variant CD44 forms, which are constitutively expressed in these blastoma cells. These findings strongly suggest that adhesion of leukemic stem cells to stromal cells via CD44 might be indispensable for their cellular defense against attack by immune cells and for maintenance of their self-renewal ability.

  15. Power Electronics and Reliability in Renewable Energy Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Ma, Ke; Zhou, Dao

    2012-01-01

    Power Electronics are needed in almost all kind of renewable energy systems. It is used both for controlling the renewable source and also for interfacing to the load, which can be grid-connected or working in stand-alone mode. More and more efforts are put into making renewable energy systems...... better in terms of reliability in order to ensure a high availability of the power sources, in this case the knowledge of mission profile of a certain application is crucial for the reliability evaluation/design of power electronics. In this paper an overview on the power electronic circuits behind...... the most common converter configurations for wind turbine and photovoltaic is done. Next different aspects of improving the system reliability are mapped. Further on examples of how to control the chip temperature in different power electronic configurations as well as operation modes for wind power...

  16. Renewables within the German Electricity System - Experiences and Needs

    Directory of Open Access Journals (Sweden)

    Martin Kaltschmitt

    2017-06-01

    Full Text Available During the last two decades renewable sources of energy as an environmentally friendly alternative to fossil fuel energy have gained more and more importance within the German electricity system. Their share has increased from less than 4 % to roughly one third of the gross electricity production in the last 25 years. Against this background, the goal of this paper is to present briefly the current status of the use of renewables within the German electricity system, to assess selected developments taking place during this development process as well as to identify given challenges and needs as well as necessary actions to pave the road for a further use of renewable sources of energy within the German electricity provision system. The political driver for the latter is the overarching goal to reduce Greenhouse Gas (GHG emissions which has been confirmed within the Paris agreement signed by the end of 2015.

  17. Hot Thermal Storage in a Variable Power, Renewable Energy System

    Science.gov (United States)

    2014-06-01

    where cost effective, increase the utilization of distributed electric power generation through wind, solar, geothermal , and biomass renewable...characteristics and may not necessarily be available in all cases. Types of direct heat energy systems include solar thermal, waste heat, and geothermal ...of super capacitor energy storage system in microgrid,” in International Conference on Sustainable Power Generation and Supply, Janjing, China

  18. Optimum transmission system expansion offshore considering renewable energy sources

    NARCIS (Netherlands)

    Torbaghan, Shahab S.; Gibescu, Madeleine

    2017-01-01

    This chapter provides an overview of transmission expansion planning (TEP) methods and their practical application. First, it discusses the strategic importance of the transmission system. Next, it describes the reasons why TEP remains a challenge for systems with a large share of renewable energy.

  19. Cancer Modeling: From Optimal Cell Renewal to Immunotherapy

    Science.gov (United States)

    Alvarado Alvarado, Cesar Leonardo

    Cancer is a disease caused by mutations in normal cells. According to the National Cancer Institute, in 2016, an estimated 1.6 million people were diagnosed and approximately 0.5 million people died from the disease in the United States. There are many factors that shape cancer at the cellular and organismal level, including genetic, immunological, and environmental components. In this thesis, we show how mathematical modeling can be used to provide insight into some of the key mechanisms underlying cancer dynamics. First, we use mathematical modeling to investigate optimal homeostatic cell renewal in tissues such as the small intestine with an emphasis on division patterns and tissue architecture. We find that the division patterns that delay the accumulation of mutations are strictly associated with the population sizes of the tissue. In particular, patterns with long chains of differentiation delay the time to observe a second-hit mutant, which is important given that for many cancers two mutations are enough to initiate a tumor. We also investigated homeostatic cell renewal under a selective pressure and find that hierarchically organized tissues act as suppressors of selection; we find that an architecture with a small number of stem cells and larger pools of transit amplifying cells and mature differentiated cells, together with long chains of differentiation, form a robust evolutionary strategy to delay the time to observe a second-hit mutant when mutations acquire a fitness advantage or disadvantage. We also formulate a model of the immune response to cancer in the presence of costimulatory and inhibitory signals. We demonstrate that the coordination of such signals is crucial to initiate an effective immune response, and while immunotherapy has become a promising cancer treatment over the past decade, these results offer some explanations for why it can fail.

  20. Photoactivated Fuel Cells (PhotoFuelCells. An alternative source of renewable energy with environmental benefits

    Directory of Open Access Journals (Sweden)

    Stavroula Sfaelou

    2016-03-01

    Full Text Available This work is a short review of Photoactivated Fuel Cells, that is, photoelectrochemical cells which consume an organic or inorganic fuel to produce renewable electricity or hydrogen. The work presents the basic features of photoactivated fuel cells, their modes of operation, the materials, which are frequently used for their construction and some ideas of cell design both for electricity and solar hydrogen production. Water splitting is treated as a special case of photoactivated fuel cell operation.

  1. Towards 100% renewable energy systems: Uncapping power system flexibility

    International Nuclear Information System (INIS)

    Papaefthymiou, G.; Dragoon, Ken

    2016-01-01

    Relying almost entirely on energy from variable renewable resources such as wind and solar energy will require a transformation in the way power systems are planned and operated. This paper outlines the necessary steps in creating power systems with the flexibility needed to maintain stability and reliability while relying primarily on variable energy resources. These steps are provided in the form of a comprehensive overview of policies, technical changes, and institutional systems, organized in three development phases: an initial phase (penetration up to about 10%) characterized by relatively mild changes to conventional power system operations and structures; a dynamic middle phase (up to about 50% penetration) characterized by phasing out conventional generation and a concerted effort to wring flexibility from existing infrastructure; and the high penetration phase that inevitably addresses how power systems operate over longer periods of weeks or months when variable generation will be in either short supply, or in over-abundance. Although this transition is likely a decades-long and incremental process and depends on the specifics of each system, the needed policies, research, demonstration projects and institutional changes need to start now precisely because of the complexity of the transformation. The list of policy actions presented in this paper can serve as a guideline to policy makers on effectuating the transition and on tracking the preparedness of systems. - Highlights: •100% VRES systems: combined analysis of all related technical and policy challenges. •Transition elements: classification of the complete range of challenges in 9 elements. •Development regimes: policy actions in 3 VRES penetration regimes (low-medium-high). •Policies: comprehensive guideline and detailed presentation of policies per regime. •Roadmap: lists of actions per regime act as transition roadmap to 100% VRES systems.

  2. Web based system for renewable energy sources assessment

    International Nuclear Information System (INIS)

    Shtrakov, Stanko; Ivanov, Lachezar South

    2011-01-01

    The RES A ssess software is developed to assist in the preliminary assessment of potential renewable energy projects. The first release includes water pumping solar systems, passive solar systems, wind, and geothermal energy and biomass. The program guides the users in the design of their systems, by providing initial estimates. By changing the system’s parameters, users are able to quickly screen an effective technology and system size depending on load, climatic conditions, and season of use. This paper describes scope of models (radiation, wind, geothermal, heat transfer) used to predict energy production from energy resource systems, climatic variables and system parameters and software technology for realising the project. Keywords: Energy projects, Renewable energy, Web system

  3. Electrical drives for direct drive renewable energy systems

    CERN Document Server

    Mueller, Markus

    2013-01-01

    Wind turbine gearboxes present major reliability issues, leading to great interest in the current development of gearless direct-drive wind energy systems. Offering high reliability, high efficiency and low maintenance, developments in these direct-drive systems point the way to the next generation of wind power, and Electrical drives for direct drive renewable energy systems is an authoritative guide to their design, development and operation. Part one outlines electrical drive technology, beginning with an overview of electrical generators for direct drive systems. Principles of electrical design for permanent magnet generators are discussed, followed by electrical, thermal and structural generator design and systems integration. A review of power electronic converter technology and power electronic converter systems for direct drive renewable energy applications is then conducted. Part two then focuses on wind and marine applications, beginning with a commercial overview of wind turbine drive systems and a...

  4. Cytokinetic Analysis of Slowly Renewing Bone-Marrow Cells after Administration of Nitrogen Mustard

    Energy Technology Data Exchange (ETDEWEB)

    Haas, R.; Fliedner, T. M.; Stehle, H. [Abteilung fuer Klinische Physiologie der Universitaet Ulm, Ulm/Donau, Federal Republic of Germany (Germany)

    1968-08-15

    The continuous or repeated administration of tritiated thymidine into pregnant rats during organogenesis provides a method for the complete labelling of newborn rats. If these are continuously injected with tritiated thymidine for the first four weeks after birth, the fraction of labelled cells of all organs and cell-renewal systems is still 100% If completely labelled animals are sacrificed at regular intervals after the discontinuance of thymidine administration, one can distinguish two groups of cells with distinct differences in their cell renewal. While the reticular cells A and B, the endothelial cells and the bone-marrow lymphocytes belong to a slowly proliferating group of cells, the differentiated myelopoietic and erythropoietic cells of the bone marrow proliferate rapidly. That labelled erythropoietic or myelopoietic cells are not found later than 6-10 days after discontinuance of tritated thymidine injection in these animals argues strongly against the hypothesis that under normal steady-state conditions a G{sub 0} fraction exists in the bone-marrow, from which stem cells are deviated into the differentiated cell pools by adequate stimuli. The administration of nitrogen mustard in a dose sufficient to cause bone-marrow aplasia neither destroys nor stimulates the reticular cells and endothelial cells of the bone-marrow matrix. These cells retain their label and remain present in normal numbers throughout the period of observation after nitrogen mustard treatment: The only cell type in the marrow that changes its labelling intensity after nitrogen mustard administration is the marrow lymphocyte. The decrease in the fraction and intensity of labelled bone-marrow lymphocytes precedes the rapid regeneration of nitrogen mustard aplastic bone-marrow. This cell type, in our opinion, would be the only cell to qualify as a stem cell, although positive evidence is still lacking. (author)

  5. Forecasting US renewables in the national energy modelling system

    International Nuclear Information System (INIS)

    Diedrich, R.; Petersik, T.W.

    2001-01-01

    The Energy information Administration (EIA) of the US Department of Energy (DOE) forecasts US renewable energy supply and demand in the context of overall energy markets using the National Energy Modelling System (NEMS). Renewables compete with other supply and demand options within the residential, commercial, industrial, transportation, and electricity sectors of the US economy. NEMS forecasts renewable energy for grid-connected electricity production within the Electricity Market Module (EM), and characterizes central station biomass, geothermal, conventional hydroelectric, municipal solid waste, solar thermal, solar photovoltaic, and wind-powered electricity generating technologies. EIA's Annual Energy Outlook 1998, projecting US energy markets, forecasts marketed renewables to remain a minor part of US energy production and consumption through to 2020. The USA is expected to remain primarily a fossil energy producer and consumer throughout the period. An alternative case indicates that biomass, wind, and to some extent geothermal power would likely increase most rapidly if the US were to require greater use of renewables for power supply, though electricity prices would increase somewhat. (author)

  6. ROS Are Required for Mouse Spermatogonial Stem Cell Self-Renewal

    OpenAIRE

    Morimoto, Hiroko; Iwata, Kazumi; Ogonuki, Narumi; Inoue, Kimiko; Ogura, Atsuo; Kanatsu-Shinohara, Mito; Morimoto, Takeshi; Yabe-Nishimura, Chihiro; Shinohara, Takashi

    2013-01-01

    Reactive oxygen species (ROS) generation is implicated in stem cell self-renewal in several tissues but is thought to be detrimental for spermatogenesis as well as spermatogonial stem cells (SSCs). Using cultured SSCs, we show that ROS are generated via the AKT and MEK signaling pathways under conditions where the growth factors glial cell line-derived neurotrophic factor and fibroblast growth factor 2 drive SSC self-renewal and, instead, stimulate self-renewal at physiological levels. SSCs d...

  7. Trends in Power Electronics and Control of Renewable Energy Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Iov, Florin; Kerekes, Tamas

    2010-01-01

    term) based energy sources to renewable energy sources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss trends of the most emerging renewable energy sources, wind energy and photovoltaics, which...... by means of power electronics are changing the future electrical infrastructure but also contributes steadily more to non-carbon based electricity production. Most focus is on the power electronics technologies used. In the case of photovoltaics transformer-less systems are discussed as they have...

  8. Design for Reliability of Power Electronics in Renewable Energy Systems

    DEFF Research Database (Denmark)

    Ma, Ke; Yang, Yongheng; Wang, Huai

    2014-01-01

    Power electronics is the enabling technology for maximizing the power captured from renewable electrical generation, e.g., the wind and solar technology, and also for an efficient integration into the grid. Therefore, it is important that the power electronics are reliable and do not have too many...... failures during operation which otherwise will increase cost for operation, maintenance and reputation. Typically, power electronics in renewable electrical generation has to be designed for 20–30 years of operation, and in order to do that, it is crucial to know about the mission profile of the power...... electronics technology as well as to know how the power electronics technology is loaded in terms of temperature and other stressors relevant, to reliability. Hence, this chapter will show the basics of power electronics technology for renewable energy systems, describe the mission profile of the technology...

  9. Nuclear-Renewable Hybrid Energy System Market Analysis Plans

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Mark

    2016-06-09

    This presentation describes nuclear-renewable hybrid energy systems (N-R HESs), states their potential benefits, provides figures for the four tightly coupled N-R HESs that NREL is currently analyzing, and outlines the analysis process that is underway.

  10. Ireland's pathway towards a 100% renewable energy-system

    DEFF Research Database (Denmark)

    Connolly, David; Leahy, Martin; Lund, Henrik

    2009-01-01

    Ireland has an abundant supply of renewable energy, a dangerous reliance on imported fossil fuels, as well as very demanding energy and CO2 targets to reach. All of these indicate that a major alternation to the current energy system is necessary, especially an increase in the utilisation of rene...

  11. Stability of impulsive systems driven by renewal processes

    NARCIS (Netherlands)

    Guerreiro Tome Antunes, D.J.; Hespanha, J.P.; Silvestre, C.J.

    2009-01-01

    Necessary and sufficient conditions are provided for stochastic stability and mean exponential stability of impulsive systems with jumps triggered by a renewal process, that is, the intervals between jumps are independent and identically distributed. The conditions for stochastic stability can be

  12. Application of fuel cell and electrolyzer as hydrogen energy storage system in energy management of electricity energy retailer in the presence of the renewable energy sources and plug-in electric vehicles

    International Nuclear Information System (INIS)

    Nojavan, Sayyad; Zare, Kazem; Mohammadi-Ivatloo, Behnam

    2017-01-01

    Highlights: • Electricity retailer determines selling price to consumers in the smart grids. • Real-time pricing is determined in comparison with fixed and time-of-use pricing. • Hydrogen storage systems and plug-in electric vehicles are used for energy sources. • Optimal charging and discharging power of electrolyser and fuel cell is determined. • Optimal charging and discharging power of plug-in electric vehicles is determined. - Abstract: The plug-in electric vehicles and hydrogen storage systems containing electrolyzer, stored hydrogen tanks and fuel cell as energy storage systems can bring various flexibilities to the energy management problem. In this paper, selling price determination and energy management problem of an electricity retailer in the smart grid under uncertainties have been proposed. Multiple energy procurement sources containing pool market, bilateral contracts, distributed generation units, renewable energy sources (photovoltaic system and wind turbine), plug-in electric vehicles and hydrogen storage systems are considered. The scenario-based stochastic method is used for uncertainty modeling of pool market prices, consumer demand, temperature, irradiation and wind speed. In the proposed model, the selling price is determined and compared by the retailer in the smart grid in three cases containing fixed pricing, time-of-use pricing and real-time pricing. It is shown that the selling price determination based on real-time pricing and flexibilities of plug-in electric vehicles and hydrogen storage systems leads to higher expected profit. The proposed model is formulated as mixed-integer linear programming that can be solved under General Algebraic Modeling System. To validate the proposed model, three types of selling price determination under four case studies are utilized and the results are compared.

  13. STAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells

    NARCIS (Netherlands)

    Schepers, Hein; Wierenga, Albertus T. J.; Vellenga, Edo; Schuringa, Jan Jacob

    2012-01-01

    The level of transcription factor activity critically regulates cell fate decisions such as hematopoietic stem cell self-renewal and differentiation. The balance between hematopoietic stem cell self-renewal and differentiation needs to be tightly controlled, as a shift toward differentiation might

  14. Intermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line.

    Directory of Open Access Journals (Sweden)

    Amanda Cinquin

    2016-04-01

    Full Text Available Self-renewing organs often experience a decline in function in the course of aging. It is unclear whether chronological age or external factors control this decline, or whether it is driven by stem cell self-renewal-for example, because cycling cells exhaust their replicative capacity and become senescent. Here we assay the relationship between stem cell cycling and senescence in the Caenorhabditis elegans reproductive system, defining this senescence as the progressive decline in "reproductive capacity," i.e. in the number of progeny that can be produced until cessation of reproduction. We show that stem cell cycling diminishes remaining reproductive capacity, at least in part through the DNA damage response. Paradoxically, gonads kept under conditions that preclude reproduction keep cycling and producing cells that undergo apoptosis or are laid as unfertilized gametes, thus squandering reproductive capacity. We show that continued activity is in fact beneficial inasmuch as gonads that are active when reproduction is initiated have more sustained early progeny production. Intriguingly, continued cycling is intermittent-gonads switch between active and dormant states-and in all likelihood stochastic. Other organs face tradeoffs whereby stem cell cycling has the beneficial effect of providing freshly-differentiated cells and the detrimental effect of increasing the likelihood of cancer or senescence; stochastic stem cell cycling may allow for a subset of cells to preserve proliferative potential in old age, which may implement a strategy to deal with uncertainty as to the total amount of proliferation to be undergone over an organism's lifespan.

  15. Renewable energy systems: A societal and technological platform

    Energy Technology Data Exchange (ETDEWEB)

    Polatidis, Heracles; Haralambopoulos, Dias A. [University of the Aegean, Mytilene (Greece). Department of Environment

    2007-02-15

    Today, the analysis of renewable energy places the emphasis on the technological and economic attributes with social and environmental impact assessment providing for a rather static, narrow frame of analysis. The participation and response of social actors and other stakeholders is usually of a traditional type, with consultation documents and public meetings, collection of complaints and suggestion schemes. This often encourages parochialism and an over-concentration on relatively trivial issues. It is, therefore, imperative to establish a new participatory planning platform to incorporate the wider socio-economic aspects of renewable energy systems and to provide for an operational analytical decomposition of them. In this work the issue of decomposition analysis is clarified, and a new agenda for the societal and technological decomposition analysis of renewable energy systems is developed. A case study is disclosed to present the relevance of the established platform for integrated (renewable) energy systems planning. Innovative aspects comprise of the simultaneous inclusion of decision analysis and social acceptance methods and tools in concert with the related public participation techniques. (author)

  16. Self-renewing Monolayer of Primary Colonic or Rectal Epithelial CellsSummary

    Directory of Open Access Journals (Sweden)

    Yuli Wang

    2017-07-01

    Full Text Available Background & Aims: Three-dimensional organoid culture has fundamentally changed the in vitro study of intestinal biology enabling novel assays; however, its use is limited because of an inaccessible luminal compartment and challenges to data gathering in a three-dimensional hydrogel matrix. Long-lived, self-renewing 2-dimensional (2-D tissue cultured from primary colon cells has not been accomplished. Methods: The surface matrix and chemical factors that sustain 2-D mouse colonic and human rectal epithelial cell monolayers with cell repertoires comparable to that in vivo were identified. Results: The monolayers formed organoids or colonoids when placed in standard Matrigel culture. As with the colonoids, the monolayers exhibited compartmentalization of proliferative and differentiated cells, with proliferative cells located near the peripheral edges of growing monolayers and differentiated cells predominated in the central regions. Screening of 77 dietary compounds and metabolites revealed altered proliferation or differentiation of the murine colonic epithelium. When exposed to a subset of the compound library, murine organoids exhibited similar responses to that of the monolayer but with differences that were likely attributable to the inaccessible organoid lumen. The response of the human primary epithelium to a compound subset was distinct from that of both the murine primary epithelium and human tumor cells. Conclusions: This study demonstrates that a self-renewing 2-D murine and human monolayer derived from primary cells can serve as a physiologically relevant assay system for study of stem cell renewal and differentiation and for compound screening. The platform holds transformative potential for personalized and precision medicine and can be applied to emerging areas of disease modeling and microbiome studies. Keywords: Colonic Epithelial Cells, Monolayer, Organoids, Compound Screening

  17. Foundations for Protecting Renewable-Rich Distribution Systems.

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, Abraham [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Brahma, Sukumar [New Mexico State Univ., Las Cruces, NM (United States); Ranade, Satish [New Mexico State Univ., Las Cruces, NM (United States)

    2016-11-01

    High proliferation of Inverter Interfaced Distributed Energy Resources (IIDERs) into the electric distribution grid introduces new challenges to protection of such systems. This is because the existing protection systems are designed with two assumptions: 1) system is single-sourced, resulting in unidirectional fault current, and (2) fault currents are easily detectable due to much higher magnitudes compared to load currents. Due to the fact that most renewables interface with the grid though inverters, and inverters restrict their current output to levels close to the full load currents, both these assumptions are no longer valid - the system becomes multi-sourced, and overcurrent-based protection does not work. The primary scope of this study is to analyze the response of a grid-tied inverter to different faults in the grid, leading to new guidelines on protecting renewable-rich distribution systems.

  18. Optimal Integration of Intermittent Renewables: A System LCOE Stochastic Approach

    Directory of Open Access Journals (Sweden)

    Carlo Lucheroni

    2018-03-01

    Full Text Available We propose a system level approach to value the impact on costs of the integration of intermittent renewable generation in a power system, based on expected breakeven cost and breakeven cost risk. To do this, we carefully reconsider the definition of Levelized Cost of Electricity (LCOE when extended to non-dispatchable generation, by examining extra costs and gains originated by the costly management of random power injections. We are thus lead to define a ‘system LCOE’ as a system dependent LCOE that takes properly into account intermittent generation. In order to include breakeven cost risk we further extend this deterministic approach to a stochastic setting, by introducing a ‘stochastic system LCOE’. This extension allows us to discuss the optimal integration of intermittent renewables from a broad, system level point of view. This paper thus aims to provide power producers and policy makers with a new methodological scheme, still based on the LCOE but which updates this valuation technique to current energy system configurations characterized by a large share of non-dispatchable production. Quantifying and optimizing the impact of intermittent renewables integration on power system costs, risk and CO 2 emissions, the proposed methodology can be used as powerful tool of analysis for assessing environmental and energy policies.

  19. Achieving a 100% Renewable Grid: Operating Electric Power Systems with Extremely High Levels of Variable Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Kroposki, Benjamin; Johnson, Brian; Zhang, Yingchen; Gevorgian, Vahan; Denholm, Paul; Hodge, Bri-Mathias; Hannegan, Bryan

    2017-03-01

    What does it mean to achieve a 100% renewable grid? Several countries already meet or come close to achieving this goal. Iceland, for example, supplies 100% of its electricity needs with either geothermal or hydropower. Other countries that have electric grids with high fractions of renewables based on hydropower include Norway (97%), Costa Rica (93%), Brazil (76%), and Canada (62%). Hydropower plants have been used for decades to create a relatively inexpensive, renewable form of energy, but these systems are limited by natural rainfall and geographic topology. Around the world, most good sites for large hydropower resources have already been developed. So how do other areas achieve 100% renewable grids? Variable renewable energy (VRE), such as wind and solar photovoltaic (PV) systems, will be a major contributor, and with the reduction in costs for these technologies during the last five years, large-scale deployments are happening around the world.

  20. Electrical Energy Storage for Renewable Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Helms, C. R. [Univ. of Texas, Dallas, TX (United States); Cho, K. J. [Univ. of Texas, Dallas, TX (United States); Ferraris, John [Univ. of Texas, Dallas, TX (United States); Balkus, Ken [Univ. of Texas, Dallas, TX (United States); Chabal, Yves [Univ. of Texas, Dallas, TX (United States); Gnade, Bruce [Univ. of Texas, Dallas, TX (United States); Rotea, Mario [Univ. of Texas, Dallas, TX (United States); Vasselli, John [Univ. of Texas, Dallas, TX (United States)

    2012-08-31

    This program focused on development of the fundamental understanding necessary to significantly improve advanced battery and ultra-capacitor materials and systems to achieve significantly higher power and energy density on the one hand, and significantly lower cost on the other. This program spanned all the way from atomic-level theory, to new nanomaterials syntheses and characterization, to system modeling and bench-scale technology demonstration. This program not only delivered significant advancements in fundamental understanding and new materials and technology, it also showcased the power of the cross-functional, multi-disciplinary teams at UT Dallas and UT Tyler for such work. These teams are continuing this work with other sources of funding from both industry and government.

  1. wnt3a but not wnt11 supports self-renewal of embryonic stem cells

    International Nuclear Information System (INIS)

    Singla, Dinender K.; Schneider, David J.; LeWinter, Martin M.; Sobel, Burton E.

    2006-01-01

    wnt proteins (wnts) promote both differentiation of midbrain dopaminergic cells and self-renewal of haematopoietic stem cells. Mouse embryonic stem (ES) cells can be maintained and self-renew on mouse feeder cell layers or in media containing leukemia inhibitory factor (LIF). However, the effects of wnts on ES cells self-renewal and differentiation are not clearly understood. In the present study, we found that conditioned medium prepared from L cells expressing wnt3a can replace feeder cell layers and medium containing LIF in maintaining ES cells in the proliferation without differentiation (self-renewal) state. By contrast, conditioned medium from NIH3T3 cells expressing wnt11 did not. Alkaline phosphatase staining and compact colony formation were used as criteria of cells being in the undifferentiated state. ES cells maintained in medium conditioned by Wnt3a expressing cells underwent freezing and thawing while maintaining properties seen with LIF maintained ES cells. Purified wnt3a did not maintain self-renewal of ES cells for prolonged intervals. Thus, other factors in the medium conditioned by wnt3a expressing cells may have contributed to maintenance of ES cells in a self-renewal state. Pluripotency of ES cells was determined with the use of embryoid bodies in vitro. PD98059, a MEK specific inhibitor, promoted the growth of undifferentiated ES cells maintained in conditioned medium from wnt3a expressing cells. By contrast, the P38 MAPK inhibitor SB230580 did not, suggesting a role for the MEK pathway in self-renewal and differentiation of ES cells maintained in the wnt3a cell conditioned medium. Thus, our results show that conditioned medium from wnt3a but not wnt11 expressing cells can maintain ES cells in self-renewal and in a pluripotent state

  2. Risk management of non-renewable energy systems

    CERN Document Server

    Verma, Ajit Kumar; Muruva, Hari Prasad

    2015-01-01

    This book describes the basic concepts of risk and reliability with detailed descriptions of the different levels of probabilistic safety assessment of nuclear power plants (both internal and external). The book also maximizes readers insights into time dependent risk analysis through several case studies, whilst risk management with respect to non renewable energy sources is also explained. With several advanced reactors utilizing the concept of passive systems, the reliability estimation of these systems are explained in detail with the book providing a reliability estimation of components through mechanistic model approach. This book is useful for advanced undergraduate and post graduate students in nuclear engineering, aerospace engineering, industrial engineering, reliability and safety engineering, systems engineering and applied probability and statistics. This book is also suitable for one-semester graduate courses on risk management of non renewable energy systems in all conventional engineering bran...

  3. New perspectives on renewable energy systems based on hydrogen

    International Nuclear Information System (INIS)

    Bose, T. K.; Agbossou, K.; Benard, P.; St-Arnaud, J-M.

    1999-01-01

    Current hydrocarbon-based energy systems, current energy consumption and the push towards the utilization of renewable energy sources, fuelled by global warming and the need to reduce atmospheric pollution are discussed. The consequences of climatic change and the obligation of Annex B countries to reduce their greenhouse gas emissions in terms of the Kyoto Protocols are reviewed. The role that renewable energy sources such as hydrogen, solar and wind energy could play in avoiding the most catastrophic consequences of rapidly growing energy consumption and atmospheric pollution in the face of diminishing conventional fossil fuel resources are examined. The focus is on hydrogen energy as a means of storing and transporting primary energy. Some favorable characteristics of hydrogen is its abundance, the fact that it can be produced utilizing renewable or non-renewable sources, and the further fact that its combustion produces three times more energy per unit of mass than oil, and six times more than coal. The technology of converting hydrogen into energy, storing energy in the form of hydrogen, and its utilization, for example in the stabilization of wind energy by way of electrolytic conversion to hydrogen, are described. Development at Hydro-Quebec's Institute of Research of a hydrogen-based autonomous wind energy system to produce electricity is also discussed. 2 tabs., 11 refs

  4. Study of renewable energy, fuel cell and demotics integration for stationary energy production

    Energy Technology Data Exchange (ETDEWEB)

    Andaloro, L.; Ferraro, M.; Sergi, F.; Brunaccini, G.; Antonucci, V. [National Research Inst., Messina (Italy)

    2009-07-01

    This paper described a study in which a small house equipped with various renewable technologies was modelled. The aim of the study was to evaluated the integration of fuel cells with various other energy sources. Technologies installed in the house included a photovoltaic (PV) system; a hydrogen system; fuel cells; a battery-storage system; and a thermal solar panel. Maximum energy savings were evaluated for different configurations and combinations of the installed energy sources. A domotic system was also used to automatically control the use of electrical appliances and improve safety and comfort. An energy side management system was designed and compared with a demand side management system. Various scenarios were simulated in order to test the energy management systems in relation to the automated domotic system.

  5. Technoeconomic analysis of renewable hydrogen production, storage, and detection systems

    Energy Technology Data Exchange (ETDEWEB)

    Mann, M.K.; Spath, P.L.; Kadam, K. [National Renewable Energy Lab., Golden, CO (United States)

    1996-10-01

    Technical and economic feasibility studies of different degrees of completeness and detail have been performed on several projects being funded by the Department of Energy`s Hydrogen Program. Work this year focused on projects at the National Renewable Energy Laboratory, although analyses of projects at other institutions are underway or planned. Highly detailed analyses were completed on a fiber optic hydrogen leak detector and a process to produce hydrogen from biomass via pyrolysis followed by steam reforming of the pyrolysis oil. Less detailed economic assessments of solar and biologically-based hydrogen production processes have been performed and focused on the steps that need to be taken to improve the competitive position of these technologies. Sensitivity analyses were conducted on all analyses to reveal the degree to which the cost results are affected by market changes and technological advances. For hydrogen storage by carbon nanotubes, a survey of the competing storage technologies was made in order to set a baseline for cost goals. A determination of the likelihood of commercialization was made for nearly all systems examined. Hydrogen from biomass via pyrolysis and steam reforming was found to have significant economic potential if a coproduct option could be co-commercialized. Photoelectrochemical hydrogen production may have economic potential, but only if low-cost cells can be modified to split water and to avoid surface oxidation. The use of bacteria to convert the carbon monoxide in biomass syngas to hydrogen was found to be slightly more expensive than the high end of currently commercial hydrogen, although there are significant opportunities to reduce costs. Finally, the cost of installing a fiber-optic chemochromic hydrogen detection system in passenger vehicles was found to be very low and competitive with alternative sensor systems.

  6. Pressure retarded osmosis as a controlling system for traditional renewables

    Science.gov (United States)

    Carravetta, Armando; Fecarotta, Oreste; La Rocca, Michele; Martino, Riccardo

    2015-04-01

    Pressure retarded osmosis (PRO) is a viable but still not diffused form of renewable energy (see Maisonneuve et al., 2015 for a recent literature review). In PRO, water from a low salinity feed solution permeates through a membrane into a pressurized, high salinity draw solution, giving rise to a positive pressure drop; then energy is obtained by depressurizing the permeate through a hydro-turbine and brackish water is discharged. Many technological, environmental and economical aspects are obstacles in the diffusion of PRO, like the vulnerability of the membranes to fouling, the impact of the brackish water on the local marine environment, the high cost of membranes, etc. We are interested in the use of PRO as a combined form of energy with other renewable energy source like solar, wind or mini hydro in water supply networks (WSN). For the wide diffusion of renewables one of the major concerns of commercial power companies is to obtain very stable form of energy to comply with prescriptions of electricity grid operators and with the instant energy demand curve. Renewables are generally very variable form of energy, for the influence of climatic conditions on available power, and of the fluctuation in water demand in WSN. PRO is a very flexible technology where with appropriate turbines and control system power can be varied continuously to compensate for variation of other source of energy. Therefore, PRO is suitable to be used as a balancing system for commercial power system. We will present a simulation of the performance of a PRO used in combination with three different renewables. In the first two scenarios PRO compensate the difference between energy demand and energy production of a solar power plant and hydro power plant in a WSN. In the third scenario PRO is used to compensate daily variation of energy production in a wind power plant. Standard curves of energy production and energy demand for southern Italy are used. In order to control PRO production an

  7. Renewable sustainable biocatalyzed electricity production in a photosynthetic algal microbial fuel cell (PAMFC)

    Energy Technology Data Exchange (ETDEWEB)

    Strik, David P.B.T.B.; Terlouw, Hilde; Hamelers, Hubertus V.M.; Buisman, Cees J.N. [Wageningen Univ. (Netherlands). Sub-Dept. of Environmental Technology

    2008-12-15

    Electricity production via solar energy capturing by living higher plants and microalgae in combination with microbial fuel cells are attractive because these systems promise to generate useful energy in a renewable, sustainable, and efficient manner. This study describes the proof of principle of a photosynthetic algal microbial fuel cell (PAMFC) based on naturally selected algae and electrochemically active microorganisms in an open system and without addition of instable or toxic mediators. The developed solar-powered PAMFC produced continuously over 100 days renewable biocatalyzed electricity. The sustainable performance of the PAMFC resulted in a maximum current density of 539 mA/m{sup 2} projected anode surface area and a maximum power production of 110 mW/m{sup 2} surface area photobioreactor. The energy recovery of the PAMFC can be increased by optimization of the photobioreactor, by reducing the competition from non-electrochemically active microorganisms, by increasing the electrode surface and establishment of a further-enriched biofilm. Since the objective is to produce net renewable energy with algae, future research should also focus on the development of low energy input PAMFCs. This is because current algae production systems have energy inputs similar to the energy present in the outcoming valuable products. (orig.)

  8. Renewable sustainable biocatalyzed electricity production in a photosynthetic algal microbial fuel cell (PAMFC).

    Science.gov (United States)

    Strik, David P B T B; Terlouw, Hilde; Hamelers, Hubertus V M; Buisman, Cees J N

    2008-12-01

    Electricity production via solar energy capturing by living higher plants and microalgae in combination with microbial fuel cells are attractive because these systems promise to generate useful energy in a renewable, sustainable, and efficient manner. This study describes the proof of principle of a photosynthetic algal microbial fuel cell (PAMFC) based on naturally selected algae and electrochemically active microorganisms in an open system and without addition of instable or toxic mediators. The developed solar-powered PAMFC produced continuously over 100 days renewable biocatalyzed electricity. The sustainable performance of the PAMFC resulted in a maximum current density of 539 mA/m2 projected anode surface area and a maximum power production of 110 mW/m2 surface area photobioreactor. The energy recovery of the PAMFC can be increased by optimization of the photobioreactor, by reducing the competition from non-electrochemically active microorganisms, by increasing the electrode surface and establishment of a further-enriched biofilm. Since the objective is to produce net renewable energy with algae, future research should also focus on the development of low energy input PAMFCs. This is because current algae production systems have energy inputs similar to the energy present in the outcoming valuable products.

  9. Renewable Energy Systems in the Power Electronics Curriculum

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Chen, Zhe; Teodorescu, Remus

    2005-01-01

    of the most important area is renewable energy systems. This paper will discuss the basic courses for the power electronics curriculum. It will also discuss how to teach power electronic systems efficiently through a projectoriented and problem-based learning approach with Aalborg University in Denmark...... as a full-scale example. Different project examples will be given as well as important laboratories for adjustable speed drives and renewable energy systems which are used at the university are described.......Power Electronics is still an emerging technology and its applications are increasing. The primary function is to convert electrical energy from one stage to another and it is used in many different applications. The power electronics curriculum is multidisciplinary covering fields like devices...

  10. Energy policies and renewable energy systems monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Di Nisio, Attilio; Savino, Mario; Spadavecchia, Maurizio [Electrical and Electronic Measurements Laboratory, Dept. of Electrical and Electronic Engineering - Politecnico di Bari, Bari (Italy)], e-mails: dinisio@misure.poliba.it, savino@misure.poliba.it, spadavecchia@misure.poliba.it

    2011-07-01

    Full text: The global energy crisis is forcing every country worldwide to review its policies on energy. The environmental disaster at Japan's Fukushima Daiichi nuclear power plant has accelerated this process. Many people around the world are citing the disaster as evidence that nuclear power would endanger the survival of mankind on earth and should be banned. Today we need to focus more substantially on energy saving, especially using smart devices with low power consumption. We have also to review the approach to the exploitation of energy and move from a philosophy 'from the ground to the subsurface' to another 'from the earth to the sun'. This paper highlights the increasing importance of solar power in meeting energy needs while achieving security of supply and minimising carbon dioxide (CO{sub 2}) emissions. It deals also with the development of solar power plants, which require a supervisory control system that improves their efficiency and reliability. (author)

  11. Stem cell self-renewal in intestinal crypt

    International Nuclear Information System (INIS)

    Simons, Benjamin D.; Clevers, Hans

    2011-01-01

    As a rapidly cycling tissue capable of fast repair and regeneration, the intestinal epithelium has emerged as a favored model system to explore the principles of adult stem cell biology. However, until recently, the identity and characteristics of the stem cell population in both the small intestine and colon has remained the subject of debate. Recent studies based on targeted lineage tracing strategies, combined with the development of an organotypic culture system, have identified the crypt base columnar cell as the intestinal stem cell, and have unveiled the strategy by which the balance between proliferation and differentiation is maintained. These results show that intestinal stem cells operate in a dynamic environment in which frequent and stochastic stem cell loss is compensated by the proliferation of neighboring stem cells. We review the basis of these experimental findings and the insights they offer into the mechanisms of homeostatic stem cell regulation.

  12. Renewable energy for sustainable electrical energy system in India

    International Nuclear Information System (INIS)

    Mallah, Subhash; Bansal, N.K.

    2010-01-01

    Present trends of electrical energy supply and demand are not sustainable because of the huge gap between demand and supply in foreseeable future in India. The path towards sustainability is exploitation of energy conservation and aggressive use of renewable energy systems. Potential of renewable energy technologies that can be effectively harnessed would depend on future technology developments and breakthrough in cost reduction. This requires adequate policy guidelines and interventions in the Indian power sector. Detailed MARKAL simulations, for power sector in India, show that full exploitation of energy conservation potential and an aggressive implementation of renewable energy technologies lead to sustainable development. Coal and other fossil fuel (gas and oil) allocations stagnated after the year 2015 and remain constant up to 2040. After the year 2040, the requirement for coal and gas goes down and carbon emissions decrease steeply. By the year 2045, 25% electrical energy can be supplied by renewable energy and the CO 2 emissions can be reduced by 72% as compared to the base case scenario. (author)

  13. Integrating renewable energy sources in the Portuguese power system

    International Nuclear Information System (INIS)

    Martins, Nuno; Cabral, Pedro; Azevedo, Helena

    2012-01-01

    The integration of large amounts of renewable energy is an important challenge for the future management of electric systems, since it affects the operation of the electric power system and the design of the transmission and distribution network infrastructure. This is specially due to the connection requirements of the renewable energy technologies, to the extension and adjustment of the grid infrastructure and to the identification of new solutions for operational reserve, in order to maintain the overall system flexibility and security. In this paper, the impact of high penetration of intermittent energy sources, expected in long term in the Portuguese Power System, is analysed and the operational reserve requirements to accomplish a reliable and reasonable electrical energy supply are identified. It was concluded that pumped storage power plants, special power plants with regulating capabilities, will have an important task to provide the operational reserve requirements of the Portuguese Power System. This technology assumes a fundamental role not only to ensure the adequate levels of security of supply but also to allow the maximum exploitation of the installed capacity in renewable energy sources. (authors)

  14. Design, analysis, operation, and advanced control of hybrid renewable energy systems

    Science.gov (United States)

    Whiteman, Zachary S.

    Because using non-renewable energy systems (e.g., coal-powered co-generation power plants) to generate electricity is an unsustainable, environmentally hazardous practice, it is important to develop cost-effective and reliable renewable energy systems, such as photovoltaics (PVs), wind turbines (WTs), and fuel cells (FCs). Non-renewable energy systems, however, are currently less expensive than individual renewable energy systems (IRESs). Furthermore, IRESs based on intermittent natural resources (e.g., solar irradiance and wind) are incapable of meeting continuous energy demands. Such shortcomings can be mitigated by judiciously combining two or more complementary IRESs to form a hybrid renewable energy system (HRES). Although previous research efforts focused on the design, operation, and control of HRESs has proven useful, no prior HRES research endeavor has taken a systematic and comprehensive approach towards establishing guidelines by which HRESs should be designed, operated, and controlled. The overall goal of this dissertation, therefore, is to establish the principles governing the design, operation, and control of HRESs resulting in cost-effective and reliable energy solutions for stationary and mobile applications. To achieve this goal, we developed and demonstrated four separate HRES principles. Rational selection of HRES type: HRES components and their sizes should be rationally selected using knowledge of component costs, availability of renewable energy resources, and expected power demands of the application. HRES design: by default, the components of a HRES should be arranged in parallel for increased efficiency and reliability. However, a series HRES design may be preferred depending on the operational considerations of the HRES components. HRES control strategy selection: the choice of HRES control strategy depends on the dynamics of HRES components, their operational considerations, and the practical limitations of the HRES end-use. HRES data

  15. Stem cell signaling. An integral program for tissue renewal and regeneration : Wnt signaling and stem cell control

    NARCIS (Netherlands)

    Clevers, Hans; Loh, Kyle M; Nusse, Roel

    2014-01-01

    Stem cells fuel tissue development, renewal, and regeneration, and these activities are controlled by the local stem cell microenvironment, the "niche." Wnt signals emanating from the niche can act as self-renewal factors for stem cells in multiple mammalian tissues. Wnt proteins are lipid-modified,

  16. Fibroblast growth factors as regulators of stem cell self-renewal and aging

    NARCIS (Netherlands)

    Yeoh, Joyce S. G.; de Haan, Gerald

    Organ and tissue dysfunction which is readily observable during aging results from a loss of cellular homeostasis and reduced stem cell self-renewal. Over the past 10 years, studies have been aimed at delineating growth factors that will sustain and promote the self-renewal potential of stem cells

  17. A smart monitoring infrastructure design for distributed renewable energy systems

    International Nuclear Information System (INIS)

    Kabalci, Ersan

    2015-01-01

    Highlights: • A smart grid model for renewable energy sources is proposed in this study. • The renewable energy conversion system is constituted with solar plants and full bridge inverter. • The power line communication is performed with QPSK modulation. • The transmission line that has 25 km length is modelled with real-time parameters. • The efficiency of system is analysed by comparing transmitted and received data. - Abstract: The automatic meter reading is essentially required in renewable grids as in conventional grids. It is intended to propose a reliable measurement system that is validated in a photovoltaic power system to meet the requirement of a renewable grid. In the presented study, the photovoltaic plants are controlled by using a widely known maximum power point tracking algorithm that is named as “Perturb and Observe”. The distribution line at the output of inverter is modelled according to realistic parameters of 25 km line. Besides carrying the generated line voltage, the grid is used as a transmission medium for the generated power measurements of photovoltaic plants and power consumptions of load plants separately. The modem constituting the power line communication manages the dual-channel transfer and transmits the consumed energy ratios of the load plants. One of the modems is located at the output of voltage source inverter and the other one of the load plants. The power consumption values of each load plants are individually measured and successfully transmitted to monitoring section in the modelled system. The obtained data that is only used for monitoring in this application can also be evaluated for automatic meter reading applications

  18. Rethinking the Future Grid: Integrated Nuclear Renewable Energy Systems: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Bragg-Sitton, S. M.; Boardman, R.; Ruth, M.; Zinaman, O.; Forsberg, C.

    2015-01-01

    The U.S. DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options, to meet both grid demand and thermal energy needs in the industrial sector. One concept under consideration by the DOE-NE and DOE-EERE is tighter coupling of nuclear and renewable energy sources in a manner that better optimizes energy use for the combined electricity, industrial manufacturing, and transportation sectors. This integration concept has been referred to as a 'hybrid system' that is capable of apportioning thermal and electrical energy to first meet the grid demand (with appropriate power conversion systems), then utilizing excess thermal and, in some cases, electrical energy to drive a process that results in an additional product.

  19. Argonaute-2-null embryonic stem cells are retarded in self-renewal ...

    Indian Academy of Sciences (India)

    Present address: Institute of Stem Cells and Regenerative Medicine, Bangalore, India ... [Chandra Shekar P, Naim A, Partha Sarathi D and Kumar S 2011 Argonaute-2-null embryonic stem cells are retarded in self-renewal ..... Research, India.

  20. Optimization of Renewable Energy Hybrid System for Grid Connected Application

    Directory of Open Access Journals (Sweden)

    Mustaqimah Mustaqimah

    2012-10-01

    Full Text Available ABSTRACT. Hybrid energy systems are pollution free, takes low cost and less gestation period, user and social friendly. Such systems are important sources of energy for shops, schools, and clinics in village communities especially in remote areas. Hybrid systems can provide electricity at a comparatively economic price in many remote areas. This paper presents a method to jointly determine the sizing and operation control of hybrid energy systems. The model, PV wind hydro and biomass hybrid system connects to grid. The system configuration of the hybrid is derived based on a theoretical domestic load at a typical location and local solar radiation, wind and water flow rate data and biomass availability. The hybrid energy system is proposed for 10 of teacher’s houses of Industrial Training Institute, Mersing. It is predicted 10 kW load consumption per house. The hybrid energy system consists of wind, solar, biomass, hydro, and grid power. Approximately energy consumption is 860 kWh/day with a 105 kW peak demand load. The proposed hybrid renewable consists of solar photovoltaic (PV panels, wind turbine, hydro turbine and biomass. Battery and inverter are included as part of back-up and storage system. It provides the economic sensitivity of hybridization and the economic and environmental benefits of using a blend of technologies. It also presents the trade off that is involved in optimizing a hybrid energy system to harness and utilize the available renewable energy resources efficiently.

  1. Sensor Buoy System for Monitoring Renewable Marine Energy Resources.

    Science.gov (United States)

    García, Emilio; Quiles, Eduardo; Correcher, Antonio; Morant, Francisco

    2018-03-22

    In this paper we present a multi-sensor floating system designed to monitor marine energy parameters, in order to sample wind, wave, and marine current energy resources. For this purpose, a set of dedicated sensors to measure the height and period of the waves, wind, and marine current intensity and direction have been selected and installed in the system. The floating device incorporates wind and marine current turbines for renewable energy self-consumption and to carry out complementary studies on the stability of such a system. The feasibility, safety, sensor communications, and buoy stability of the floating device have been successfully checked in real operating conditions.

  2. Renewable energy systems the earthscan expert guide to renewable energy technologies for home and business

    CERN Document Server

    Jenkins, Dilwyn

    2013-01-01

    This book is the long awaited guide for anyone interested in renewables at home or work. It sweeps away scores of common misconceptions while clearly illustrating the best in renewable and energy efficiency technologies. A fully illustrated guide to renewable energy for the home and small business, the book provides an expert overview of precisely which sustainable energy technologies are appropriate for wide-spread domestic and small business application. The sections on different renewable energy options provide detailed descriptions of each technology along with case studies, installatio

  3. Power electronics - The key technology for Renewable Energy Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Ma, Ke; Yang, Yongheng

    2014-01-01

    The energy paradigms in many countries (e.g. Germany and Denmark) have experienced a significant change from fossil-based resources to clean renewables (e.g. wind turbines and photovoltaics) in the past few decades. The scenario of highly penetrated renewables is going to be further enhanced...... - Denmark expects to be 100 % fossil-free by 2050. Consequently, it is required that the production, distribution and use of the energy should be as technologically efficient as possible and incentives to save energy at the end-user should also be strengthened. In order to realize the transition smoothly...... and effectively, energy conversion systems, currently based on power electronics technology, will again play an essential role in this energy paradigm shift. Using highly efficient power electronics in power generation, power transmission/distribution and end-user application, together with advanced control...

  4. Involvement of extracellular factors in maintaining self-renewal of neural stem cell by nestin.

    Science.gov (United States)

    Di, Chun Guang; Xiang, Andy Peng; Jia, Lei; Liu, Jun Feng; Lahn, Bruce T; Ma, Bao Feng

    2014-07-09

    Nestin knockout leads to embryonic lethality and self-renewal deficiency in neural stem cells (NSCs). However, how nestin maintains self-renewal remains uncertain. Here, we used the dosage effect of nestin in heterozygous mice (Nes+/-) to study self-renewal of NSCs. With existing extracellular signaling in vivo or in vitro, nestin levels do not affect proliferation ability or apoptosis when compared between Nes+/- and Nes+/+ NSCs. However, self-renewal ability of Nes+/- NSCs is impaired when plated at a low cell density and completely lost at a clonal density. This deficiency in self-renewal at a clonal density is rescued using a medium conditioned by Nes+/+ NSCs. In addition, the Akt signaling pathway is altered at low density and reversed by conditioned medium. Our data show that secreted factors contribute toward maintaining self-renewal of NSCs by nestin, potentially through Akt signaling.

  5. Cell renewal of glomerular cell types in normal rats. An autoradiographic analysis

    International Nuclear Information System (INIS)

    Pabst, R.; Sterzel, R.B.

    1983-01-01

    Normal adult Sprague-Dawley rats received either a single or repetitive injection of the DNA precursor 3 H-thymidine ( 3 H-TdR). For autoradiography semi-thin sections were prepared 2 hr to 14 days after labeling. The majority of labeled cells noted in glomerular tufts were endothelial cells. Mesangial cells had a lower production rate. Podocytes revealed no evidence of proliferation. Bowman's capsule cells showed a higher labeling index than tuft cells at all times. Neither the urinary nor the vascular pole was found to be a proliferative zone for Bowman's capsule cells. The flash and repetitive labeling experiments demonstrated a constant rate of cell renewal of about 1% per day, resulting in a long life span for endothelial and mesangial cells as well as Bowman's capsule cells. These data provide a basis for cell kinetic studies in models of glomerular diseases

  6. Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.

    Science.gov (United States)

    Soucie, Erinn L; Weng, Ziming; Geirsdóttir, Laufey; Molawi, Kaaweh; Maurizio, Julien; Fenouil, Romain; Mossadegh-Keller, Noushine; Gimenez, Gregory; VanHille, Laurent; Beniazza, Meryam; Favret, Jeremy; Berruyer, Carole; Perrin, Pierre; Hacohen, Nir; Andrau, J-C; Ferrier, Pierre; Dubreuil, Patrice; Sidow, Arend; Sieweke, Michael H

    2016-02-12

    Differentiated macrophages can self-renew in tissues and expand long term in culture, but the gene regulatory mechanisms that accomplish self-renewal in the differentiated state have remained unknown. Here we show that in mice, the transcription factors MafB and c-Maf repress a macrophage-specific enhancer repertoire associated with a gene network that controls self-renewal. Single-cell analysis revealed that, in vivo, proliferating resident macrophages can access this network by transient down-regulation of Maf transcription factors. The network also controls embryonic stem cell self-renewal but is associated with distinct embryonic stem cell-specific enhancers. This indicates that distinct lineage-specific enhancer platforms regulate a shared network of genes that control self-renewal potential in both stem and mature cells. Copyright © 2016, American Association for the Advancement of Science.

  7. Stem cell self-renewal in intestinal crypt

    NARCIS (Netherlands)

    Simons, B.D.; Clevers, H.

    2011-01-01

    As a rapidly cycling tissue capable of fast repair and regeneration, the intestinal epithelium has emerged as a favored model system to explore the principles of adult stem cell biology. However, until recently, the identity and characteristics of the stem cell population in both the small intestine

  8. The self-renewal signaling pathways utilized by gastric cancer stem cells.

    Science.gov (United States)

    Fu, Ying; Li, Hui; Hao, Xishan

    2017-04-01

    Gastric cancer is a leading cause of cancer-related mortality worldwide. Cancer stem cells are the source of tumor recurrence and metastasis. Self-renewal is a marker of cancer stem cells and also the basis of long-lasting survival and tumor progression. Although the mechanism of gastric cancer stem cell self-renewal is not clear, there are several signaling pathways and environmental factors known to be involved. This mini review describes recent developments in the self-renewal signaling pathway of gastric cancer stem cell research. Advancements made in this field of research will likely support the development of novel therapeutic strategies for gastric cancer.

  9. Renewable Electricity-to-Grid Integration | Energy Systems Integration

    Science.gov (United States)

    Facility | NREL Renewable Electricity-to-Grid Integration Renewable Electricity-to-Grid Integration NREL works with industry partners to optimize strategies for effectively interconnecting renewable renewable electric grid integration work includes research and development (R&D) on advanced inverters

  10. Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

    OpenAIRE

    Soucie, E.L.; Weng, Z.; Geirsdottir, L.; Molawi, K.; Maurizio, J.; Fenouil, R.; Mossadegh-Keller, N.; Gimenez, G.; VanHille, L.; Beniazza, M.; Favret, J.; Berruyer, C.; Perrin, P.; Hacohen, N.; Andrau, J.C.

    2016-01-01

    Differentiated macrophages can self-renew in tissues and expand long-term in culture, but the gene regulatory mechanisms that accomplish self-renewal in the differentiated state have remained unknown. Here we show that in mice, the transcription factors MafB and c-Maf repress a macrophage-specific enhancer repertoire associated with a gene network controlling self-renewal. Single cell analysis revealed that, in vivo, proliferating resident macrophages can access this network by transient down...

  11. Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells.

    Science.gov (United States)

    Hunt, Geoffrey C; Singh, Purva; Schwarzbauer, Jean E

    2012-09-10

    Pluripotent cells are attached to the extracellular matrix (ECM) as they make cell fate decisions within the stem cell niche. Here we show that the ubiquitous ECM protein fibronectin is required for self-renewal decisions by cultured mouse embryonic stem (mES) cells. Undifferentiated mES cells produce fibronectin and assemble a fibrillar matrix. Increasing the level of substrate fibronectin increased cell spreading and integrin receptor signaling through focal adhesion kinase, while concomitantly inducing the loss of Nanog and Oct4 self-renewal markers. Conversely, reducing fibronectin production by mES cells growing on a feeder-free gelatin substrate caused loss of cell adhesion, decreased integrin signaling, and decreased expression of self-renewal markers. These effects were reversed by providing the cells with exogenous fibronectin, thereby restoring adhesion to the gelatin substrate. Interestingly, mES cells do not adhere directly to the gelatin substrate, but rather adhere indirectly through gelatin-bound fibronectin, which facilitates self-renewal via its effects on cell adhesion. These results provide new insights into the mechanism of regulation of self-renewal by growth on a gelatin-coated surface. The effects of increasing or decreasing fibronectin levels show that self-renewal depends on an intermediate level of cell-fibronectin interactions. By providing cell adhesive signals that can act with other self-renewal factors to maintain mES cell pluripotency, fibronectin is therefore a necessary component of the self-renewal signaling pathway in culture. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells.

    Science.gov (United States)

    Wang, Ruoxing; Guo, Yan-Lin

    2012-10-01

    Embryonic stem cells (ESCs) have unlimited capacity for self-renewal and can differentiate into various cell types when induced. They also have an unusual cell cycle control mechanism driven by constitutively active cyclin dependent kinases (Cdks). In mouse ESCs (mESCs). It is proposed that the rapid cell proliferation could be a necessary part of mechanisms that maintain mESC self-renewal and pluripotency, but this hypothesis is not in line with the finding in human ESCs (hESCs) that the length of the cell cycle is similar to differentiated cells. Therefore, whether rapid cell proliferation is essential for the maintenance of mESC state remains unclear. We provide insight into this uncertainty through chemical intervention of mESC cell cycle. We report here that inhibition of Cdks with olomoucine II can dramatically slow down cell proliferation of mESCs with concurrent down-regulation of cyclin A, B and E, and the activation of the Rb pathway. However, mESCs display can recover upon the removal of olomoucine II and are able to resume normal cell proliferation without losing self-renewal and pluripotency, as demonstrated by the expression of ESC markers, colony formation, embryoid body formation, and induced differentiation. We provide a mechanistic explanation for these observations by demonstrating that Oct4 and Nanog, two major transcription factors that play critical roles in the maintenance of ESC properties, are up-regulated via de novo protein synthesis when the cells are exposed to olomoucine II. Together, our data suggest that short-term inhibition of cell proliferation does not compromise the basic properties of mESCs. Copyright © 2012 Elsevier Inc. All rights reserved.

  13. Seeding of single hemopoietic stem cells and self renewal of committed stem cells

    International Nuclear Information System (INIS)

    Brecher, G.

    1986-01-01

    Single cells and two to five proliferating cells were transfused into mice whose own stem cells had been killed by irradiation. When a small inoculum of 50,000 AB marrow cells was given only 4 of 20 recipients survived, but all 4 had only PGK A enzyme in their peripheral blood cells. The results indicate that the survivors received a single pluripotential stem cell capable of proliferating. Survivors showed no deterioration in their blood picture after many months. It was concluded that there is no clonal succession in the marrow cells. Further studies with transfusions of 100,000 and 10,000,000 marrow cells after lethal irradiation suggest that there is production of committed stem cells with significant self-renewal

  14. Renewal of reactor cooling system of JMTR. Reactor building site

    International Nuclear Information System (INIS)

    Onoue, Ryuji; Kawamata, Takanori; Otsuka, Kaoru; Sekine, Katsunori; Koike, Sumio; Gorai, Shigeru; Nishiyama, Yutaka; Fukasaku, Akitomi

    2012-03-01

    The Japan Materials Testing Reactor (JMTR) is a light water moderated and cooled tank-type reactor, and its thermal power is 50 MW. The JMTR is categorized as high flux testing reactors in the world. The JMTR has been utilized for irradiation experiments of nuclear fuels and materials, as well as for radioisotope productions since the first criticality in March 1968 until August 2006. JAEA is decided to refurbish the JMTR as an important fundamental infrastructure to promote the nuclear research and development. And The JMTR refurbishment work is carried out for 4 years from 2007. Before refurbishment work, from August 2006 to March 2007, all concerned renewal facilities were selected from evaluation on their damage and wear in terms of aging. Facilities which replacement parts are no longer manufactured or not likely to be manufactured continuously in near future, are selected as renewal ones. Replace priority was decided with special attention to safety concerns. A monitoring of aging condition by the regular maintenance activity is an important factor in selection of continuous using after the restart. In this report, renewal of the cooling system within refurbishment facilities in the JMTR is summarized. (author)

  15. Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ruoxing [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States); Guo, Yan-Lin, E-mail: yanlin.guo@usm.edu [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States)

    2012-10-01

    Embryonic stem cells (ESCs) have unlimited capacity for self-renewal and can differentiate into various cell types when induced. They also have an unusual cell cycle control mechanism driven by constitutively active cyclin dependent kinases (Cdks). In mouse ESCs (mESCs). It is proposed that the rapid cell proliferation could be a necessary part of mechanisms that maintain mESC self-renewal and pluripotency, but this hypothesis is not in line with the finding in human ESCs (hESCs) that the length of the cell cycle is similar to differentiated cells. Therefore, whether rapid cell proliferation is essential for the maintenance of mESC state remains unclear. We provide insight into this uncertainty through chemical intervention of mESC cell cycle. We report here that inhibition of Cdks with olomoucine II can dramatically slow down cell proliferation of mESCs with concurrent down-regulation of cyclin A, B and E, and the activation of the Rb pathway. However, mESCs display can recover upon the removal of olomoucine II and are able to resume normal cell proliferation without losing self-renewal and pluripotency, as demonstrated by the expression of ESC markers, colony formation, embryoid body formation, and induced differentiation. We provide a mechanistic explanation for these observations by demonstrating that Oct4 and Nanog, two major transcription factors that play critical roles in the maintenance of ESC properties, are up-regulated via de novo protein synthesis when the cells are exposed to olomoucine II. Together, our data suggest that short-term inhibition of cell proliferation does not compromise the basic properties of mESCs. -- Highlights: Black-Right-Pointing-Pointer Inhibition of Cdks slows down mESCs proliferation. Black-Right-Pointing-Pointer mESCs display remarkable recovery capacity from short-term cell cycle interruption. Black-Right-Pointing-Pointer Short-term cell cycle interruption does not compromise mESC self-renewal. Black

  16. Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells

    International Nuclear Information System (INIS)

    Wang, Ruoxing; Guo, Yan-Lin

    2012-01-01

    Embryonic stem cells (ESCs) have unlimited capacity for self-renewal and can differentiate into various cell types when induced. They also have an unusual cell cycle control mechanism driven by constitutively active cyclin dependent kinases (Cdks). In mouse ESCs (mESCs). It is proposed that the rapid cell proliferation could be a necessary part of mechanisms that maintain mESC self-renewal and pluripotency, but this hypothesis is not in line with the finding in human ESCs (hESCs) that the length of the cell cycle is similar to differentiated cells. Therefore, whether rapid cell proliferation is essential for the maintenance of mESC state remains unclear. We provide insight into this uncertainty through chemical intervention of mESC cell cycle. We report here that inhibition of Cdks with olomoucine II can dramatically slow down cell proliferation of mESCs with concurrent down-regulation of cyclin A, B and E, and the activation of the Rb pathway. However, mESCs display can recover upon the removal of olomoucine II and are able to resume normal cell proliferation without losing self-renewal and pluripotency, as demonstrated by the expression of ESC markers, colony formation, embryoid body formation, and induced differentiation. We provide a mechanistic explanation for these observations by demonstrating that Oct4 and Nanog, two major transcription factors that play critical roles in the maintenance of ESC properties, are up-regulated via de novo protein synthesis when the cells are exposed to olomoucine II. Together, our data suggest that short-term inhibition of cell proliferation does not compromise the basic properties of mESCs. -- Highlights: ► Inhibition of Cdks slows down mESCs proliferation. ► mESCs display remarkable recovery capacity from short-term cell cycle interruption. ► Short-term cell cycle interruption does not compromise mESC self-renewal. ► Oct4 and Nanog are up-regulated via de novo synthesis by cell cycle interruption.

  17. Tissue-resident adult stem cell populations of rapidly self-renewing organs

    NARCIS (Netherlands)

    Barker, N.; Bartfeld, S.; Clevers, H.

    2010-01-01

    The epithelial lining of the intestine, stomach, and skin is continuously exposed to environmental assault, imposing a requirement for regular self-renewal. Resident adult stem cell populations drive this renewal, and much effort has been invested in revealing their identity. Reliable adult stem

  18. RETHINKING THE FUTURE GRID: INTEGRATED NUCLEAR-RENEWABLE ENERGY SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    S.M. Bragg-Sitton; R. Boardman

    2014-12-01

    The 2013 electricity generation mix in the United States consisted of ~13% renewables (hydropower, wind, solar, geothermal), 19% nuclear, 27% natural gas, and 39% coal. In the 2011 State of the Union Address, President Obama set a clean energy goal for the nation: “By 2035, 80 percent of America’s electricity will come from clean energy sources. Some folks want wind and solar. Others want nuclear, clean coal and natural gas. To meet this goal we will need them all.” The U.S. Department of Energy (DOE) Offices of Nuclear Energy (NE) and Energy Efficiency and Renewable Energy (EERE) recognize that “all of the above” means that we are called to best utilize all available clean energy sources. To meet the stated environmental goals for electricity generation and for the broader energy sector, there is a need to transform the energy infrastructure of the U.S. and elsewhere. New energy systems must be capable of significantly reducing environmental impacts in an efficient and economically viable manner while utilizing both hydrocarbon resources and clean energy generation sources. The U.S. DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options, to meet both grid demand and thermal energy needs in the industrial sector. A concept being advanced by the DOE-NE and DOE-EERE is tighter coupling of nuclear and renewable energy sources in a manner that better optimizes energy use for the combined electricity, industrial manufacturing, and the transportation sectors. This integration concept has been referred to as a “hybrid system” that is capable of apportioning thermal and electrical energy to first meet the grid demand (with appropriate power conversion systems), then utilizing excess thermal and, in some cases, electrical energy to drive a process that results in an additional product. For the purposes of the present work, the hybrid system would

  19. Myostatin signals through Pax7 to regulate satellite cell self-renewal

    International Nuclear Information System (INIS)

    McFarlane, Craig; Hennebry, Alex; Thomas, Mark; Plummer, Erin; Ling, Nicholas; Sharma, Mridula; Kambadur, Ravi

    2008-01-01

    Myostatin, a Transforming Growth Factor-beta (TGF-β) super-family member, has previously been shown to negatively regulate satellite cell activation and self-renewal. However, to date the mechanism behind Myostatin function in satellite cell biology is not known. Here we show that Myostatin signals via a Pax7-dependent mechanism to regulate satellite cell self-renewal. While excess Myostatin inhibited Pax7 expression via ERK1/2 signaling, an increase in Pax7 expression was observed following both genetic inactivation and functional antagonism of Myostatin. As a result, we show that either blocking or inactivating Myostatin enhances the partitioning of the fusion-incompetent self-renewed satellite cell lineage (high Pax7 expression, low MyoD expression) from the pool of actively proliferating myogenic precursor cells. Consistent with this result, over-expression of Pax7 in C2C12 myogenic cells resulted in increased self-renewal through a mechanism which slowed both myogenic proliferation and differentiation. Taken together, these results suggest that increased expression of Pax7 promotes satellite cell self-renewal, and furthermore Myostatin may control the process of satellite cell self-renewal through regulation of Pax7. Thus we speculate that, in addition to the intrinsic factors (such as Pax7), extrinsic factors both positive and negative in nature, will play a major role in determining the stemness of skeletal muscle satellite cells

  20. Proceedings of World Renewable Energy Congress '99

    International Nuclear Information System (INIS)

    Kamaruzzaman Sopian; Mohd Yusof Othman; Baharuddin Yatim

    2000-01-01

    The congress discussed the following subjects, 1. The role of renewable energy in the next millenium; 2. Challenges in the commercialization of renewable energy; 3. The role and agenda for renewable energy towards sustainable development. Topics covered in the technical session were biomass conversion; solar thermal technologies and systems; solar photovoltaic s; renewable energy economics, financing and policy; renewable energy education; climate and the environment; energy and architecture; energy management; wind and hydro technologies and systems; hydrogen and fuel cell

  1. Databases in Cloud - Solutions for Developing Renewable Energy Informatics Systems

    Directory of Open Access Journals (Sweden)

    Adela BARA

    2017-08-01

    Full Text Available The paper presents the data model of a decision support prototype developed for generation monitoring, forecasting and advanced analysis in the renewable energy filed. The solutions considered for developing this system include databases in cloud, XML integration, spatial data representation and multidimensional modeling. This material shows the advantages of Cloud databases and spatial data representation and their implementation in Oracle Database 12 c. Also, it contains a data integration part and a multidimensional analysis. The presentation of output data is made using dashboards.

  2. Optimizing Storage and Renewable Energy Systems with REopt

    Energy Technology Data Exchange (ETDEWEB)

    Elgqvist, Emma M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Anderson, Katherine H. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cutler, Dylan S. [National Renewable Energy Lab. (NREL), Golden, CO (United States); DiOrio, Nicholas A. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Laws, Nicholas D. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Olis, Daniel R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Walker, H. A. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-12-27

    Under the right conditions, behind the meter (BTM) storage combined with renewable energy (RE) technologies can provide both cost savings and resiliency. Storage economics depend not only on technology costs and avoided utility rates, but also on how the technology is operated. REopt, a model developed at NREL, can be used to determine the optimal size and dispatch strategy for BTM or off-grid applications. This poster gives an overview of three applications of REopt: Optimizing BTM Storage and RE to Extend Probability of Surviving Outage, Optimizing Off-Grid Energy System Operation, and Optimizing Residential BTM Solar 'Plus'.

  3. Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes.

    Science.gov (United States)

    Zhao, Jingyao; Chen, Xufeng; Song, Guangrong; Zhang, Jiali; Liu, Haifeng; Liu, Xiaolong

    2017-01-10

    Hematopoietic stem cells (HSCs) are able to both self-renew and differentiate. However, how individual HSC makes the decision between self-renewal and differentiation remains largely unknown. Here we report that ablation of the key epigenetic regulator Uhrf1 in the hematopoietic system depletes the HSC pool, leading to hematopoietic failure and lethality. Uhrf1-deficient HSCs display normal survival and proliferation, yet undergo erythroid-biased differentiation at the expense of self-renewal capacity. Notably, Uhrf1 is required for the establishment of DNA methylation patterns of erythroid-specific genes during HSC division. The expression of these genes is enhanced in the absence of Uhrf1, which disrupts the HSC-division modes by promoting the symmetric differentiation and suppressing the symmetric self-renewal. Moreover, overexpression of one of the up-regulated genes, Gata1, in HSCs is sufficient to phenocopy Uhrf1-deficient HSCs, which show impaired HSC symmetric self-renewal and increased differentiation commitment. Taken together, our findings suggest that Uhrf1 controls the self-renewal versus differentiation of HSC through epigenetically regulating the cell-division modes, thus providing unique insights into the relationship among Uhrf1-mediated DNA methylation, cell-division mode, and HSC fate decision.

  4. Interregional technology transfer on advanced materials and renewable energy systems

    International Nuclear Information System (INIS)

    Agrianidis, P.; David, C.; Anthymidis, K.; Ekhrawat, M.

    2008-01-01

    Advanced materials are used in most industrial sectors and human activities and all developing and developed countries as well as international organizations eg. United Nations have established work groups, which survey the national and global state and developments in the area of advanced materials trying to establish strategies on that crucial technology sector. These strategies are focused on research and technology activities including education and vocation training, as well as stimulus for the starting up of new industrial applications. To introduce such a concept in Greece and especially in Northern Greece, the Technological Education Institute of Serres has initiated an Interregional technology transfer project in this scientific field. This project includes mod topics of advanced materials technology with emphasison specific industrial applications (renewable energy systems). The project demonstrates the development of a prototype photovoltaic thermal system in terms of a new industrial product. The product development procedure consists of steps such as initial product design, materials selection and processing, prototype design and manufacturing, quality control, performance optimization, but also control of materials ecocompatibility according to the national trends of life cycle design and recycling techniques. Keywords: Interregional technology transfer, materials, renewable energy systems

  5. Interregional technology transfer on advanced materials and renewable energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Agrianidis, P.; David, C.; Anthymidis, K.; Ekhrawat, M. [Department of Mechanical Engineering, Technological Educational Institute of Serres, Serres (Greece)

    2008-07-01

    Advanced materials are used in most industrial sectors and human activities and all developing and developed countries as well as international organizations eg. United Nations have established work groups, which survey the national and global state and developments in the area of advanced materials trying to establish strategies on that crucial technology sector. These strategies are focused on research and technology activities including education and vocation training, as well as stimulus for the starting up of new industrial applications. To introduce such a concept in Greece and especially in Northern Greece, the Technological Education Institute of Serres has initiated an Interregional technology transfer project in this scientific field. This project includes mod topics of advanced materials technology with emphasison specific industrial applications (renewable energy systems). The project demonstrates the development of a prototype photovoltaic thermal system in terms of a new industrial product. The product development procedure consists of steps such as initial product design, materials selection and processing, prototype design and manufacturing, quality control, performance optimization, but also control of materials ecocompatibility according to the national trends of life cycle design and recycling techniques. Keywords: Interregional technology transfer, materials, renewable energy systems.

  6. Energy Storage Applications in Power Systems with Renewable Energy Generation

    Science.gov (United States)

    Ghofrani, Mahmoud

    In this dissertation, we propose new operational and planning methodologies for power systems with renewable energy sources. A probabilistic optimal power flow (POPF) is developed to model wind power variations and evaluate the power system operation with intermittent renewable energy generation. The methodology is used to calculate the operating and ramping reserves that are required to compensate for power system uncertainties. Distributed wind generation is introduced as an operational scheme to take advantage of the spatial diversity of renewable energy resources and reduce wind power fluctuations using low or uncorrelated wind farms. The POPF is demonstrated using the IEEE 24-bus system where the proposed operational scheme reduces the operating and ramping reserve requirements and operation and congestion cost of the system as compared to operational practices available in the literature. A stochastic operational-planning framework is also proposed to adequately size, optimally place and schedule storage units within power systems with high wind penetrations. The method is used for different applications of energy storage systems for renewable energy integration. These applications include market-based opportunities such as renewable energy time-shift, renewable capacity firming, and transmission and distribution upgrade deferral in the form of revenue or reduced cost and storage-related societal benefits such as integration of more renewables, reduced emissions and improved utilization of grid assets. A power-pool model which incorporates the one-sided auction market into POPF is developed. The model considers storage units as market participants submitting hourly price bids in the form of marginal costs. This provides an accurate market-clearing process as compared to the 'price-taker' analysis available in the literature where the effects of large-scale storage units on the market-clearing prices are neglected. Different case studies are provided to

  7. Renewable energy resources in Pakistan: status, potential and information systems

    International Nuclear Information System (INIS)

    Khan, A.M.

    1991-01-01

    This paper provides some details regarding the characteristic properties, potential and assessment of renewable energy compared with other forms of energy sources. It gives status of renewable energy sources in Pakistan. It also lights about the agencies providing technical information regarding renewable energy in Pakistan as well as suggestions and recommendations for the development of these resources, and over view the present status of renewable energy sources. (author)

  8. Is there dependence and systemic risk between oil and renewable energy stock prices?

    International Nuclear Information System (INIS)

    Reboredo, Juan C.

    2015-01-01

    We study systemic risk and dependence between oil and renewable energy markets using copulas to characterize the dependence structure and to compute the conditional value-at-risk as a measure of systemic risk. We found significant time-varying average and symmetric tail dependence between oil returns and several global and sectoral renewable energy indices. Our evidence on systemic risk indicates that oil price dynamics significantly contributes around 30% to downside and upside risk of renewable energy companies. These results have important implications for risk management and renewable energy policies. - Highlights: • We study systemic risk and dependence between oil and renewable energy markets. • Dependence and conditional value-at-risk is obtained through copulas. • Oil and renewable energy displayed time-varying average and symmetric tail dependence. • Oil price contribution to the downside and upside risks of renewable energy companies was around 30%

  9. Hematopoietic stem cell aging and self-renewal

    NARCIS (Netherlands)

    Dykstra, Brad; de Haan, Gerald

    A functional decline of the immune system occurs during organismal aging that is attributable, in large part, to changes in the hematopoietic stem cell (HSC) compartment. In the mouse, several hallmark age-dependent changes in the HSC compartment have been identified, including an increase in HSC

  10. Power System Study for Renewable Energy Interconnection in Malaysia

    International Nuclear Information System (INIS)

    Askar, O F; Ramachandaramurthy, V K

    2013-01-01

    The renewable energy (RE) sector has grown exponentially in Malaysia with the introduction of the Feed-In-Tariff (FIT) by the Ministry of Energy, Green Technology and Water. Photovoltaic, biogas, biomass and mini hydro are among the renewable energy sources which offer a lucrative tariff to incite developers in taking the green technology route. In order to receive the FIT, a developer is required by the utility company to perform a power system analysis which will determine the technical feasibility of an RE interconnection to the utility company's existing grid system. There are a number of aspects which the analysis looks at, the most important being the load flow and fault levels in the network after the introduction of an RE source. The analysis is done by modelling the utility company's existing network and simulating the network with the interconnection of an RE source. The results are then compared to the values before an interconnection is made as well as ensuring the voltage rise or the increase in fault levels do not violate any pre-existing regulations set by the utility company. This paper will delve into the mechanics of performing a load flow analysis and examining the results obtained.

  11. Power System Study for Renewable Energy Interconnection in Malaysia

    Science.gov (United States)

    Askar, O. F.; Ramachandaramurthy, V. K.

    2013-06-01

    The renewable energy (RE) sector has grown exponentially in Malaysia with the introduction of the Feed-In-Tariff (FIT) by the Ministry of Energy, Green Technology and Water. Photovoltaic, biogas, biomass and mini hydro are among the renewable energy sources which offer a lucrative tariff to incite developers in taking the green technology route. In order to receive the FIT, a developer is required by the utility company to perform a power system analysis which will determine the technical feasibility of an RE interconnection to the utility company's existing grid system. There are a number of aspects which the analysis looks at, the most important being the load flow and fault levels in the network after the introduction of an RE source. The analysis is done by modelling the utility company's existing network and simulating the network with the interconnection of an RE source. The results are then compared to the values before an interconnection is made as well as ensuring the voltage rise or the increase in fault levels do not violate any pre-existing regulations set by the utility company. This paper will delve into the mechanics of performing a load flow analysis and examining the results obtained.

  12. Somatic ACE regulates self-renewal of mouse spermatogonial stem cells via the MAPK signaling pathway.

    Science.gov (United States)

    Gao, Tingting; Zhao, Xin; Liu, Chenchen; Shao, Binbin; Zhang, Xi; Li, Kai; Cai, Jinyang; Wang, Su; Huang, Xiaoyan

    2018-05-24

    Spermatogonial stem cell (SSC) self-renewal is an indispensable part of spermatogenesis. Angiotensin I-converting enzyme (ACE) is a zinc dipeptidyl carboxypeptidase that plays a critical role in regulation of the renin-angiotensin system. Here, we used RT-PCR and Western blot analysis to confirm that somatic ACE (sACE) but not testicular ACE (tACE) is highly expressed in mouse testis before postpartum day 7 and in cultured SSCs. Our results revealed that sACE is located on the membrane of SSCs. Treating cultured SSCs with the ACE competitive inhibitor captopril was found to inhibit sACE activity, and significantly reduced the proliferation rate of SSCs. Microarray analysis identified 651 genes with significant differential expression. KEGG pathway analysis showed that these differentially expressed genes are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway and cell cycle. sACE was found to play an important role in SSC self-renewal via the regulation of MAPK-dependent cell proliferation.

  13. Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal

    OpenAIRE

    Ye, Shoudong; Zhang, Tao; Tong, Chang; Zhou, Xingliang; He, Kan; Ban, Qian; Liu, Dahai; Ying, Qi-Long

    2017-01-01

    ABSTRACT Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3 promotes ESC self-renewal by abrogating T-cell factor 3 (TCF3)-mediated repression of the pluripotency network. How inhibition of MEK mediates ESC self-renewal, however, remains largely unknown. Here, we show that inhibition of MEK can significantly suppress lymphoid enhancer factor 1 (LEF1...

  14. Primary frequency regulation supported by battery storage systems in power systems dominated by renewable energy sources

    DEFF Research Database (Denmark)

    Turk, Ana; Sandelic, Monika; Noto, Giancarlo

    2018-01-01

    replaced by intermittent renewable generators. Therefore, maintaining system quality and stability in terms of power system frequency control is one of the major challenges that requires new resources and their system integration. Battery energy storage systems (BESS), as fast-acting energy storage systems...

  15. Power quality analysis of hybrid renewable energy system

    Directory of Open Access Journals (Sweden)

    Rinchin W. Mosobi

    2015-12-01

    Full Text Available An hybrid renewable energy sources consisting of solar photovoltaic, wind energy system, and a microhydro system is proposed in this paper. This system is suitable for supplying electricity to isolated locations or remote villages far from the grid supply. The solar photovoltaic system is modeled with two power converters, the first one being a DC-DC converter along with an maximum power point tracking to achieve a regulated DC output voltage and the second one being a DC-AC converter to obtain AC output. The wind energy system is modeled with a wind-turbine prime mover with varying wind speed and fixed pitch angle to drive an self excited induction generator (SEIG. Owing to inherent drooping characteristics of the SEIG, a closed loop turbine input system is incorporated. The microhydro system is modeled with a constant input power to drive an SEIG. The three different sources are integrated through an AC bus and the proposed hybrid system is supplied to R, R-L, and induction motor loads. A static compensator is proposed to improve the load voltage and current profiles; it also mitigates the harmonic contents of the voltage and current. The static synchronous compensator is realized by means of a three-phase IGBT-based current-controlled voltage source inverter with a self-supporting DC bus. The complete system is modeled and simulated using Matlab/Simulink. The simulation results obtained illustrate the feasibility of the proposed system and are found to be satisfactory.

  16. Albumin-associated lipids regulate human embryonic stem cell self-renewal.

    Directory of Open Access Journals (Sweden)

    Francesc R Garcia-Gonzalo

    Full Text Available BACKGROUND: Although human embryonic stem cells (hESCs hold great promise as a source of differentiated cells to treat several human diseases, many obstacles still need to be surmounted before this can become a reality. First among these, a robust chemically-defined system to expand hESCs in culture is still unavailable despite recent advances in the understanding of factors controlling hESC self-renewal. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we attempted to find new molecules that stimulate long term hESC self-renewal. In order to do this, we started from the observation that a commercially available serum replacement product has a strong positive effect on the expansion of undifferentiated hESCs when added to a previously reported chemically-defined medium. Subsequent experiments demonstrated that the active ingredient within the serum replacement is lipid-rich albumin. Furthermore, we show that this activity is trypsin-resistant, strongly suggesting that lipids and not albumin are responsible for the effect. Consistent with this, lipid-poor albumin shows no detectable activity. Finally, we identified the major lipids bound to the lipid-rich albumin and tested several lipid candidates for the effect. CONCLUSIONS/SIGNIFICANCE: Our discovery of the role played by albumin-associated lipids in stimulating hESC self-renewal constitutes a significant advance in the knowledge of how hESC pluripotency is maintained by extracellular factors and has important applications in the development of increasingly chemically defined hESC culture systems.

  17. Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal.

    Science.gov (United States)

    Kanatsu-Shinohara, Mito; Tanaka, Takashi; Ogonuki, Narumi; Ogura, Atsuo; Morimoto, Hiroko; Cheng, Pei Feng; Eisenman, Robert N; Trumpp, Andreas; Shinohara, Takashi

    2016-12-01

    Myc plays critical roles in the self-renewal division of various stem cell types. In spermatogonial stem cells (SSCs), Myc controls SSC fate decisions because Myc overexpression induces enhanced self-renewal division, while depletion of Max, a Myc-binding partner, leads to meiotic induction. However, the mechanism by which Myc acts on SSC fate is unclear. Here we demonstrate a critical link between Myc/Mycn gene activity and glycolysis in SSC self-renewal. In SSCs, Myc/Mycn are regulated by Foxo1, whose deficiency impairs SSC self-renewal. Myc/Mycn-deficient SSCs not only undergo limited self-renewal division but also display diminished glycolytic activity. While inhibition of glycolysis decreased SSC activity, chemical stimulation of glycolysis or transfection of active Akt1 or Pdpk1 (phosphoinositide-dependent protein kinase 1 ) augmented self-renewal division, and long-term SSC cultures were derived from a nonpermissive strain that showed limited self-renewal division. These results suggested that Myc-mediated glycolysis is an important factor that increases the frequency of SSC self-renewal division. © 2016 Kanatsu-Shinohara et al.; Published by Cold Spring Harbor Laboratory Press.

  18. USING REGIONAL RENEWABLE ENERGY RESOURSES FOR HEATING SUPPLY SYSTEMS

    Directory of Open Access Journals (Sweden)

    O. M. Pshinko

    2017-02-01

    Full Text Available Purpose. The study analyzed the possibility and conditions for the effective operation of heating systems during the transition of the heat-generating capacity to biofuels energy. The straw of cereal crops, which are prevailing in Dnipro region, is used for this. The main purpose is scientific calculation of opportunities and cost of specific measures for such a transition. As an example it was taken the boiler-room of campus at Dnipropetrovsk National University of Railway Transport named after Academician V. Lazaryan (DNURT that consumes natural gas. Methodology. The work analyses the legislative base of Ukraine, which promotes the using of renewable energy sources as fuel, as well as the incentive mechanisms for the development of this trend. The paper identifies opportunities of Prydniprovsk region to ensure straw supply for the boiler-room. Cost parameters of cargo transportation on the territory of Ukraine in 2016, which depend on the distance and the size of the trucks, are analysed. These indicators, as well as indicators related to its purchase, are considered together with energy potential of using the straw as fuel. Findings. With existing in Ukraine (as of 2016 the grain yielding capacity in the agriculture and cost indicators in the field of transportations, the transition of capacity share to biofuel is sufficiently profitable. The thermal power unit cost can be reduced fourfold. Originality. For the first time it is proposed to use the new integrated approaches to assess the cost of thermal power unit boiler with its transition to the use of renewable energy sources. The authors also proposed a new logistics delivery of these sources to the place of their application. From a technical and cost points of view it was determined the optimal order of capacity transfer for new renewable sources of energy in a given region depending on the structure of areas under crops and their productivity. Originality. The introduction of the

  19. Wave power integration with a renewable hydrogen energy system. Paper no. IGEC-1-085

    International Nuclear Information System (INIS)

    St. Germain, L.; Wild, P.; Rowe, A.

    2005-01-01

    In British Columbia, approximately 90% of the electricity generated comes from hydroelectric facilities while another abundant and renewable resource, ocean wave energy, is not being utilized at all. Technologies exist that can capture and convert wave energy but there are few studies examining systemic integration of wave energy devices. This work examines the potential to use wave energy as an input into a hydrogen-based renewable energy system. A model of an oscillating water column (OWC) was developed as a module within TRNSYS where it can be coupled to other existing hydrogen-specific components such as an electrolyser, storage device, and fuel cell. The OWC model accounts for device geometry, dynamics, and generator efficiency. For this particular study, wave profiles generated from hourly average data for a location on the west coast of Vancouver Island are used as a resource input. An analysis of the potential to utilise wave energy is carried out with an emphasis on overall system efficiency and resulting device scaling. The results of the integration of wave energy with other renewable energy inputs into a hydrogen-based system are used to make recommendations regarding technical feasibility of wave power projects on Vancouver Island. (author)

  20. Two distinct mechanisms silence chinmo in Drosophila neuroblasts and neuroepithelial cells to limit their self-renewal.

    Science.gov (United States)

    Dillard, Caroline; Narbonne-Reveau, Karine; Foppolo, Sophie; Lanet, Elodie; Maurange, Cédric

    2018-01-25

    Whether common principles regulate the self-renewing potential of neural stem cells (NSCs) throughout the developing central nervous system is still unclear. In the Drosophila ventral nerve cord and central brain, asymmetrically dividing NSCs, called neuroblasts (NBs), progress through a series of sequentially expressed transcription factors that limits self-renewal by silencing a genetic module involving the transcription factor Chinmo. Here, we find that Chinmo also promotes neuroepithelium growth in the optic lobe during early larval stages by boosting symmetric self-renewing divisions while preventing differentiation. Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of neural stem cell self-renewal with organismal growth. In contrast, chinmo silencing in NBs is post-transcriptional and does not require ecdysone. Thus, during Drosophila development, humoral cues or tissue-intrinsic temporal specification programs respectively limit self-renewal in different types of neural progenitors through the transcriptional and post-transcriptional regulation of the same transcription factor. © 2018. Published by The Company of Biologists Ltd.

  1. Optimizing the U.S. Electric System with a High Penetration of Renewables

    Science.gov (United States)

    Corcoran, B. A.; Jacobson, M. Z.

    2013-12-01

    As renewable energy generators are increasingly being installed throughout the U.S., there is growing interest in interconnecting diverse renewable generators (primarily wind and solar) across large geographic areas through an enhanced transmission system. This reduces variability in the aggregate power output, increases system reliability, and allows for the development of the best overall group of renewable technologies and sites to meet the load. Studies are therefore needed to determine the most efficient and economical plan to achieve large area interconnections in a future electric system with a high penetration of renewables. This research quantifies the effects of aggregating electric load together with diverse renewable generation throughout the ten Federal Energy Regulatory Commission (FERC) regions in the contiguous U.S. A deterministic linear program has been built in AMPL (A Mathematical Programming Language) to solve for the least-cost organizational structure and system (generators, transmission, and storage) for a highly renewable electric grid. The analysis will 1) examine a highly renewable 2006 electric system, including various sensitivity cases and additional system components such as additional load from electric vehicles, and 2) create a 'roadmap' from the existing 2006 system to a highly renewable system in 2030, accounting for projected price and demand changes and generator retirements based on age and environmental regulations. Ideally, results from this study will offer insight for a federal renewable energy policy (such as a renewable portfolio standard) and how to best organize U.S. regions for transmission planning.

  2. Identification of key factors regulating self-renewal and differentiation in EML hematopoietic precursor cells by RNA-sequencing analysis.

    Science.gov (United States)

    Zong, Shan; Deng, Shuyun; Chen, Kenian; Wu, Jia Qian

    2014-11-11

    Hematopoietic stem cells (HSCs) are used clinically for transplantation treatment to rebuild a patient's hematopoietic system in many diseases such as leukemia and lymphoma. Elucidating the mechanisms controlling HSCs self-renewal and differentiation is important for application of HSCs for research and clinical uses. However, it is not possible to obtain large quantity of HSCs due to their inability to proliferate in vitro. To overcome this hurdle, we used a mouse bone marrow derived cell line, the EML (Erythroid, Myeloid, and Lymphocytic) cell line, as a model system for this study. RNA-sequencing (RNA-Seq) has been increasingly used to replace microarray for gene expression studies. We report here a detailed method of using RNA-Seq technology to investigate the potential key factors in regulation of EML cell self-renewal and differentiation. The protocol provided in this paper is divided into three parts. The first part explains how to culture EML cells and separate Lin-CD34+ and Lin-CD34- cells. The second part of the protocol offers detailed procedures for total RNA preparation and the subsequent library construction for high-throughput sequencing. The last part describes the method for RNA-Seq data analysis and explains how to use the data to identify differentially expressed transcription factors between Lin-CD34+ and Lin-CD34- cells. The most significantly differentially expressed transcription factors were identified to be the potential key regulators controlling EML cell self-renewal and differentiation. In the discussion section of this paper, we highlight the key steps for successful performance of this experiment. In summary, this paper offers a method of using RNA-Seq technology to identify potential regulators of self-renewal and differentiation in EML cells. The key factors identified are subjected to downstream functional analysis in vitro and in vivo.

  3. Lhx2 expression promotes self-renewal of a distinct multipotential hematopoietic progenitor cell in embryonic stem cell-derived embryoid bodies.

    Directory of Open Access Journals (Sweden)

    Lina Dahl

    Full Text Available The molecular mechanisms regulating the expansion of the hematopoietic system including hematopoietic stem cells (HSCs in the fetal liver during embryonic development are largely unknown. The LIM-homeobox gene Lhx2 is a candidate regulator of fetal hematopoiesis since it is expressed in the fetal liver and Lhx2(-/- mice die in utero due to severe anemia. Moreover, expression of Lhx2 in embryonic stem (ES cell-derived embryoid bodies (EBs can lead to the generation of HSC-like cell lines. To further define the role of this transcription factor in hematopoietic regulation, we generated ES cell lines that enabled tet-inducible expression of Lhx2. Using this approach we observed that Lhx2 expression synergises with specific signalling pathways, resulting in increased frequency of colony forming cells in developing EB cells. The increase in growth factor-responsive progenitor cells directly correlates to the efficiency in generating HSC-like cell lines, suggesting that Lhx2 expression induce self-renewal of a distinct multipotential hematopoietic progenitor cell in EBs. Signalling via the c-kit tyrosine kinase receptor and the gp130 signal transducer by IL-6 is necessary and sufficient for the Lhx2 induced self-renewal. While inducing self-renewal of multipotential progenitor cells, expression of Lhx2 inhibited proliferation of primitive erythroid precursor cells and interfered with early ES cell commitment, indicating striking lineage specificity of this effect.

  4. Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells

    OpenAIRE

    Hunt, Geoffrey C.; Singh, Purva; Schwarzbauer, Jean E.

    2012-01-01

    Pluripotent cells are attached to the extracellular matrix (ECM) as they make cell fate decisions within the stem cell niche. Here we show that the ubiquitous ECM protein fibronectin is required for self-renewal decisions by cultured mouse embryonic stem (mES) cells. Undifferentiated mES cells produce fibronectin and assemble a fibrillar matrix. Increasing the level of substrate fibronectin increased cell spreading and integrin receptor signaling through focal adhesion kinase, while concomita...

  5. Nuclear-Renewable Energy Systems Secondary Product Market Analysis Study

    Energy Technology Data Exchange (ETDEWEB)

    Deason, Wesley Ray [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-06-01

    In order to properly create a program surrounding the development of any technological concept it is necessary to fully understand the market in which it is being developed. In the case of Integrated Nuclear-Renewable Hybrid Energy Systems (HES), there are two economic markets in which it must be able to participate in: the electricity market and the secondary product market associated with the specific system. The purpose of the present report is to characterize the secondary product market in the U.S. and to provide recommendations for further developing the HES program. While HESs have been discussed in depth in many other reports, it is helpful to discuss them briefly in the present work [REF]. The concept of the HES can be deduced to a system, featuring a combination of a nuclear power plant, a renewable energy source, and an industrial manufacturing plant . The system is designed in a fashion that allows it either to produce electricity or to manufacture a secondary product as needed. The primary benefit of this concept lies in its ability to maximize economic performance of the integrated system and to manufacture products in a carbon-free manner. A secondary benefit is the enhanced supply-side flexibility gained by allowing the HES to economically provide grid services. A key tenant to nuclear power plant economics in today’s electricity market is their ability to operate at a very high capacity factor. Unfortunately, in regions with a high penetration of renewable energy, the carbon free energy produced by nuclear power may not be needed at all times. This forces the nuclear power plant to find a user for its excess capacity. This may include paying the electric grid to find a user, releasing energy to the environment by ‘dumping steam’, or reducing power. If the plant is unable to economically or safely do any of these actions, the plant is at risk of being shutdown. In order to allow for nuclear power plants to continue to contribute carbon free

  6. Nuclear-Renewable Energy Systems Secondary Product Market Analysis Study

    International Nuclear Information System (INIS)

    Deason, Wesley Ray

    2015-01-01

    In order to properly create a program surrounding the development of any technological concept it is necessary to fully understand the market in which it is being developed. In the case of Integrated Nuclear-Renewable Hybrid Energy Systems (HES), there are two economic markets in which it must be able to participate in: the electricity market and the secondary product market associated with the specific system. The purpose of the present report is to characterize the secondary product market in the U.S. and to provide recommendations for further developing the HES program. While HESs have been discussed in depth in many other reports, it is helpful to discuss them briefly in the present work [REF]. The concept of the HES can be deduced to a system, featuring a combination of a nuclear power plant, a renewable energy source, and an industrial manufacturing plant . The system is designed in a fashion that allows it either to produce electricity or to manufacture a secondary product as needed. The primary benefit of this concept lies in its ability to maximize economic performance of the integrated system and to manufacture products in a carbon-free manner. A secondary benefit is the enhanced supply-side flexibility gained by allowing the HES to economically provide grid services. A key tenant to nuclear power plant economics in today's electricity market is their ability to operate at a very high capacity factor. Unfortunately, in regions with a high penetration of renewable energy, the carbon free energy produced by nuclear power may not be needed at all times. This forces the nuclear power plant to find a user for its excess capacity. This may include paying the electric grid to find a user, releasing energy to the environment by -dumping steam', or reducing power. If the plant is unable to economically or safely do any of these actions, the plant is at risk of being shutdown. In order to allow for nuclear power plants to continue to contribute carbon free

  7. Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells

    NARCIS (Netherlands)

    van Gosliga, Djoke; Schepers, Hein; Rizo, Aleksandra; van der Kolk, Dorina; Vellenga, Edo; Schuringa, Jan Jacob

    2007-01-01

    Objective. With the emergence of the concept of the leukemia stem cell, assays to study them remain pivotal in understanding (leukemic) stem cell biology. Methods. We have cultured acute myeloid leukemia CD34(+) cells on bone marrow stroma. Long-term expansion was monitored and self-renewal was

  8. Fine-tuning Hematopoiesis: Microenvironmental factors regulating self-renewal and differentiation of hematopoietic stem cells

    NARCIS (Netherlands)

    T.C. Luis (Tiago)

    2010-01-01

    markdownabstract__Abstract__ Hematopoietic stem cells (HSCs) have the ability to self renew and generate all lineages of blood cells. Although it is currently well established that hematopoietic stem cells (HSCs) regenerate the blood compartment, it was only in the 1960s that was introduced the

  9. Renewable technologies for generation systems in islands and their application to Cozumel Island, Mexico

    OpenAIRE

    Mendoza Vizcaino, Javier; Sumper, Andreas; Sudrià Andreu, Antoni; Ramirez, J.M.

    2016-01-01

    The electric generation systems on islands are based generally on fossil fuel. This fact and its supply make the electricity cost higher than in systems used in the continent. In this article, we present a review of the renewable energy generation systems on islands. To do it we analysed 77 islands from 45 different countries. This work will allow us to know how the implementation of renewable energy sources could help these islands in developing a renewable and sustainable energy sector, inc...

  10. Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal

    Science.gov (United States)

    Ito, Kyoko; Ito, Keisuke

    2016-01-01

    Although the stem cells of various tissues remain in the quiescent state to maintain their undifferentiated state, they also undergo cell divisions as required, and if necessary, even a single stem cell is able to provide for lifelong tissue homeostasis. Stem cell populations are precisely controlled by the balance between their symmetric and asymmetric divisions, with their division patterns determined by whether the daughter cells involved retain their self-renewal capacities. Recent studies have reported that metabolic pathways and the distribution of mitochondria are regulators of the division balance of stem cells and that metabolic defects can shift division balance toward symmetric commitment, which leads to stem cell exhaustion. It has also been observed that in asymmetric division, old mitochondria, which are central metabolic organelles, are segregated to the daughter cell fated to cell differentiation, whereas in symmetric division, young and old mitochondria are equally distributed between both daughter cells. Thus, metabolism and mitochondrial biology play important roles in stem cell fate decisions. As these decisions directly affect tissue homeostasis, understanding their regulatory mechanisms in the context of cellular metabolism is critical. PMID:27482603

  11. CD47 regulates renal tubular epithelial cell self-renewal and proliferation following renal ischemia reperfusion.

    Science.gov (United States)

    Rogers, Natasha M; Zhang, Zheng J; Wang, Jiao-Jing; Thomson, Angus W; Isenberg, Jeffrey S

    2016-08-01

    Defects in renal tubular epithelial cell repair contribute to renal ischemia reperfusion injury, cause acute kidney damage, and promote chronic renal disease. The matricellular protein thrombospondin-1 and its receptor CD47 are involved in experimental renal ischemia reperfusion injury, although the role of this interaction in renal recovery is unknown. We found upregulation of self-renewal genes (transcription factors Oct4, Sox2, Klf4 and cMyc) in the kidney of CD47(-/-) mice after ischemia reperfusion injury. Wild-type animals had minimal self-renewal gene expression, both before and after injury. Suggestive of cell autonomy, CD47(-/-) renal tubular epithelial cells were found to increase expression of the self-renewal genes. This correlated with enhanced proliferative capacity compared with cells from wild-type mice. Exogenous thrombospondin-1 inhibited self-renewal gene expression in renal tubular epithelial cells from wild-type but not CD47(-/-) mice, and this was associated with decreased proliferation. Treatment of renal tubular epithelial cells with a CD47 blocking antibody or CD47-targeting small interfering RNA increased expression of some self-renewal transcription factors and promoted cell proliferation. In a syngeneic kidney transplant model, treatment with a CD47 blocking antibody increased self-renewal transcription factor expression, decreased tissue damage, and improved renal function compared with that in control mice. Thus, thrombospondin-1 via CD47 inhibits renal tubular epithelial cell recovery after ischemia reperfusion injury through inhibition of proliferation/self-renewal. Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  12. Nuclear Energy and Renewables interaction: System Effects in Low-carbon Electricity Systems

    International Nuclear Information System (INIS)

    Keppler, Jan Horst; Cometto, Marco

    2013-01-01

    This report presents a synthesis of the OECD/NEA study 'Nuclear Energy and Renewables: System Effects in Low-carbon Electricity Systems'. It addresses the increasingly important interactions of variable renewables and dispatchable energy technologies, such as nuclear power, in terms of their effects on electricity systems. These effects add costs to the production of electricity, which are not usually transparent. The report recommends that decision-makers should take into account such system costs and internalise them according to a 'generator pays' principle, which is currently not the case. Analysing data from six OECD/NEA countries, the study finds that including the system costs of variable renewables at the level of the electricity grid increases the total costs of electricity supply by up to one-third, depending on technology, country and penetration levels. In addition, it concludes that, unless the current market subsidies for renewables are altered, dispatchable technologies will increasingly not be replaced as they reach their end of life and consequently security of supply will suffer. This implies that significant changes in management and cost allocation will be needed to generate the flexibility required for an economically viable coexistence of nuclear energy and renewables in increasingly de-carbonised electricity systems

  13. Modeling sustainability in renewable energy supply chain systems

    Science.gov (United States)

    Xie, Fei

    This dissertation aims at modeling sustainability of renewable fuel supply chain systems against emerging challenges. In particular, the dissertation focuses on the biofuel supply chain system design, and manages to develop advanced modeling framework and corresponding solution methods in tackling challenges in sustaining biofuel supply chain systems. These challenges include: (1) to integrate "environmental thinking" into the long-term biofuel supply chain planning; (2) to adopt multimodal transportation to mitigate seasonality in biofuel supply chain operations; (3) to provide strategies in hedging against uncertainty from conversion technology; and (4) to develop methodologies in long-term sequential planning of the biofuel supply chain under uncertainties. All models are mixed integer programs, which also involves multi-objective programming method and two-stage/multistage stochastic programming methods. In particular for the long-term sequential planning under uncertainties, to reduce the computational challenges due to the exponential expansion of the scenario tree, I also developed efficient ND-Max method which is more efficient than CPLEX and Nested Decomposition method. Through result analysis of four independent studies, it is found that the proposed modeling frameworks can effectively improve the economic performance, enhance environmental benefits and reduce risks due to systems uncertainties for the biofuel supply chain systems.

  14. The first step towards a 100% renewable energy-system for Ireland

    DEFF Research Database (Denmark)

    Connolly, D.; Lund, Henrik; Mathiesen, Brian Vad

    2011-01-01

    , it is essential that Ireland begins to utilise its renewable resources more effectively. Therefore, this study presents the first step towards a 100% renewable energy-system for Ireland. The energy-system analysis tool used was EnergyPLAN, as it accounts for all sectors of the energy-system that need...

  15. Human mesenchymal stem cells self-renew and differentiate according to a deterministic hierarchy.

    Directory of Open Access Journals (Sweden)

    Rahul Sarugaser

    Full Text Available BACKGROUND: Mesenchymal progenitor cells (MPCs have been isolated from a variety of connective tissues, and are commonly called "mesenchymal stem cells" (MSCs. A stem cell is defined as having robust clonal self-renewal and multilineage differentiation potential. Accordingly, the term "MSC" has been criticised, as there is little data demonstrating self-renewal of definitive single-cell-derived (SCD clonal populations from a mesenchymal cell source. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that a tractable MPC population, human umbilical cord perivascular cells (HUCPVCs, was capable of multilineage differentiation in vitro and, more importantly, contributed to rapid connective tissue healing in vivo by producing bone, cartilage and fibrous stroma. Furthermore, HUCPVCs exhibit a high clonogenic frequency, allowing us to isolate definitive SCD parent and daughter clones from mixed gender suspensions as determined by Y-chromosome fluorescent in situ hybridization. CONCLUSIONS/SIGNIFICANCE: Analysis of the multilineage differentiation capacity of SCD parent clones and daughter clones enabled us to formulate a new hierarchical schema for MSC self-renewal and differentiation in which a self-renewing multipotent MSC gives rise to more restricted self-renewing progenitors that gradually lose differentiation potential until a state of complete restriction to the fibroblast is reached.

  16. The role of PV electricity generation in fully renewable energy supply systems

    International Nuclear Information System (INIS)

    Lehmann, H.; Peter, S.

    2004-01-01

    A sustainable energy supply will be based on renewable energies and it must use available resources efficiently. Earlier or later the energy supply will rely completely on renewable sources. A solar energy system that provides a reliable energy supply throughout the year includes the consistent use of local renewable energy sources (e.g. PV) wherever possible. Using Japan as a example it was shown that the vision of a full renewable energy supply, even with high shares of domestic sources is possible. Detailed simulations of such a system show that the PV systems play an important role delivering electricity at peak demand times. (authors)

  17. Renewable energy in energy efficient, low-pollution systems

    Energy Technology Data Exchange (ETDEWEB)

    Johansson, Bengt

    1997-03-01

    Energy use accounts for the dominating fraction of total sulphur dioxide (SO{sub 2}), nitrogen oxide (NO{sub x}), volatile organic compounds (VOCs) and carbon dioxide (CO{sub 2}) emissions. In this thesis, different strategies for reducing these emissions are evaluated, using a bottom-up approach. CO{sub 2} emissions from electricity and heat production in western Scania, Sweden, can be reduced by 25% and the emissions of acidifying gases (SO{sub 2} and NO{sub x}) by 50% by the year 2010, compared with 1988 levels, using energy systems based on efficient end-use technologies, cogeneration of heat and electricity, renewable energy sources and low-pollution energy conversion technologies. Exhaust-pipe NO{sub x} emissions from the Swedish transportation sector can be reduced by 50 percent by the year 2015, compared with 1991, by implementing the best available vehicle technologies. Exhaust-pipe emissions of CO{sub 2} can be stabilized at the 1991 level. With further technical development and the use of fuels from renewable sources of energy, NO{sub x} emissions can be reduced by 75 percent and CO{sub 2} emissions by 80 percent compared with 1991 levels. Swedish biomass resources are large, and, assuming production conditions around 2015, about 200 TWh/year could be utilised for energy. Major reductions in CO{sub 2} emissions could be achieved by substituting biomass for fossil fuels in heat, electricity and transportation fuel production. Transportation fuels produced from cellulosic biomass are likely to be less expensive than transportation fuels from conventional biomass feedstocks such as oil plants, sugar-beet and cereals. 90 refs, 3 figs, 5 tabs

  18. Ferritin nanoparticles for improved self-renewal and differentiation of human neural stem cells.

    Science.gov (United States)

    Lee, Jung Seung; Yang, Kisuk; Cho, Ann-Na; Cho, Seung-Woo

    2018-01-01

    Biomaterials that promote the self-renewal ability and differentiation capacity of neural stem cells (NSCs) are desirable for improving stem cell therapy to treat neurodegenerative diseases. Incorporation of micro- and nanoparticles into stem cell culture has gained great attention for the control of stem cell behaviors, including proliferation and differentiation. In this study, ferritin, an iron-containing natural protein nanoparticle, was applied as a biomaterial to improve the self-renewal and differentiation of NSCs and neural progenitor cells (NPCs). Ferritin nanoparticles were added to NSC or NPC culture during cell growth, allowing for incorporation of ferritin nanoparticles during neurosphere formation. Compared to neurospheres without ferritin treatment, neurospheres with ferritin nanoparticles showed significantly promoted self-renewal and cell-cell interactions. When spontaneous differentiation of neurospheres was induced during culture without mitogenic factors, neuronal differentiation was enhanced in the ferritin-treated neurospheres. In conclusion, we found that natural nanoparticles can be used to improve the self-renewal ability and differentiation potential of NSCs and NPCs, which can be applied in neural tissue engineering and cell therapy for neurodegenerative diseases.

  19. Technological Decision to Renewable Energy Usage Biogas for Off-grid Systems Consumption

    Directory of Open Access Journals (Sweden)

    Zubkova Marina

    2016-01-01

    Full Text Available This paper presents the results of the energy experiments based on electrochemical researches and the thermodynamic calculations, which are carried out on the hydrogenous fuel with the residual content of methane obtained from biogas selected organic waste. Energy indicators are examined in comparison to electrolysis hydrogen. The use of technical and electro physical indicators together with parameters of the fuel operating allowed assessing energy efficiency the module reformer - fuel cell running on a non-standard hydrogenous fuel. Numerical characteristic the efficiency of workflows fuel system reformer – fuel cell is about 39%. To operate the power installation with a predetermined capacity amount used of hydrogenous fuel is comparable to required electrolysis hydrogen amount. Shown the possibility of creation the systems of power supply based on new hydrogen technologies using renewable energy resources local waste. Confirms the relatively high efficiency the usage of hydrogenous fuel for the tasks of off-grid systems consumption.

  20. Heating technologies for limiting biomass consumption in 100% renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Connolly, David

    2011-01-01

    district heating enables the use of combined heat and power production (CPH) and other renewable resources than biomass such as large-scale solar thermal, large-heat pumps, geothermal heat, industrial surplus heat etc. which is important for reducing the biomass consumption. Where the energy density......The utilisation of biomass poses large challenges in renewable energy systems and buildings account for a substantial part of the energy supply also in 100% renewable energy systems. The analyses of heating technologies show that district heating systems are especially important in limiting...... the dependence on biomass resources and to create cost effective systems. District heating systems are especially important in renewable energy systems with large amounts of fluctuating renewable energy sources as it enables fuel efficient and lower cost energy systems with thermal heat storages. And also...

  1. Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation

    Directory of Open Access Journals (Sweden)

    Xihang Chen

    2018-01-01

    Full Text Available Autophagy is a highly conserved cellular process that degrades modified, surplus, or harmful cytoplasmic components by sequestering them in autophagosomes which then fuses with the lysosome for degradation. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining cellular homeostasis, as well as for remodeling during normal development. Impairment of this process has been implicated in various diseases, in the pathogenic response to bacterial and viral infections, and in aging. Pluripotent stem cells, with their ability to self-replicate and to give rise to any specialized cell type, are very valuable resources for cell-based medical therapies and open a number of promising avenues for studying human development and disease. It has been suggested that autophagy is vital for the maintenance of cellular homeostasis in stem cells, and subsequently more in-depth knowledge about the regulation of autophagy in stem cell biology has been acquired recently. In this review, we describe the most significant advances in the understanding of autophagy regulation in hematopoietic and mesenchymal stem cells, as well as in induced pluripotent stem cells. In particular, we highlight the roles of various autophagy activities in the regulation of self-renewal and differentiation of these stem cells.

  2. Activin pathway enhances colorectal cancer stem cell self-renew and tumor progression.

    Science.gov (United States)

    Liu, Rui; Wang, Jun-Hua; Xu, Chengxiong; Sun, Bo; Kang, Sa-Ouk

    2016-10-28

    Activin belongs to transforming growth factor (TGF)-β super family of growth and differentiation factors and activin pathway participated in broad range of cell process. Studies elaborated activin pathway maintain pluripotency in human stem cells and suggest that the function of activin/nodal signaling in self-renew would be conserved across embryonic and adult stem cells. In this study, we tried to determine the effect of activin signaling pathway in regulation of cancer stem cells as a potential target for cancer therapy in clinical trials. A population of colorectal cancer cells was selected by the treatment of activin A. This population of cell possessed stem cell character with sphere formation ability. We demonstrated activin pathway enhanced the colorectal cancer stem cells self-renew and contribute to colorectal cancer progression in vivo. Targeting activin pathway potentially provide effective strategy for colorectal cancer therapy. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties.

    Science.gov (United States)

    Kubota, Hiroshi; Wu, Xin; Goodyear, Shaun M; Avarbock, Mary R; Brinster, Ralph L

    2011-08-01

    Previous studies suggest that exogenous factors crucial for spermatogonial stem cell (SSC) self-renewal are conserved among several mammalian species. Since glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are critical for rodent SSC self-renewal, we hypothesized that they might promote self-renewal of nonrodent SSCs. Therefore, we cultured testicular germ cells from prepubertal rabbits in the presence of GDNF and FGF2 and found they proliferated indefinitely as cellular clumps that displayed characteristics previously identified for rodent SSCs. The rabbit germ cells could not be maintained on mouse embryonic fibroblast (STO) feeders that support rodent SSC self-renewal in vitro but were rather supported on mouse yolk sac-derived endothelial cell (C166) feeder layers. Proliferation of rabbit germ cells was dependent on GDNF. Of critical importance was that clump-forming rabbit germ cells colonized seminiferous tubules of immunodeficient mice, proliferated for at least 6 mo, while retaining an SSC phenotype in the testes of recipient mice, indicating that they were rabbit SSCs. This study demonstrates that GDNF is a mitogenic factor promoting self-renewal that is conserved between rodent and rabbit SSCs; with an evolutionary separation of ∼ 60 million years. These findings provide a foundation to study the mechanisms governing SSC self-renewal in nonrodent species.

  4. Smart Cooling Controlled System Exploiting Photovoltaic Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    Ahmad Atieh

    2018-03-01

    Full Text Available A smart cooling system to control the ambient temperature of a premise in Amman, Jordan, is investigated and implemented. The premise holds 650 people and has 14 air conditioners with the cooling capacity ranging from 3 to 5 ton refrigerant (TR each. The control of the cooling system includes implementing different electronics circuits that are used to sense the ambient temperature and humidity, count the number of people in the premise and then turn ON/OFF certain air conditioner(s. The data collected by different electronic circuits are fed wirelessly to a microcontroller, which decides which air conditioner will be turned ON/OFF, its location and its desired set cooling temperature. The cooling system is integrated with an on-grid solar photovoltaic energy system to minimize the operational cost of the overall cooling system.

  5. New insights into redox regulation of stem cell self-renewal and differentiation.

    Science.gov (United States)

    Ren, Fenglian; Wang, Kui; Zhang, Tao; Jiang, Jingwen; Nice, Edouard Collins; Huang, Canhua

    2015-08-01

    Reactive oxygen species (ROS), the natural byproducts of aerobic metabolism, are precisely orchestrated to evoke diverse signaling pathways. To date, studies have focused mainly on the detrimental effects of ROS in stem cells. Recently, accumulating evidence has suggested that ROS also function as second messengers that modulate stem cell self-renewal and differentiation by regulating intricate signaling networks. Although many efforts have been made to clarify the general effects of ROS on signal transduction in stem cells, less is known about the initial and direct executors of ROS signaling, which are known as 'redox sensors'. Modifications of cysteine residues in redox sensors are of significant importance in the modulation of protein function in response to different redox conditions. Intriguingly, most key molecules in ROS signaling and cell cycle regulation (including transcriptional factors and kinases) that are crucial in the regulation of stem cell self-renewal and differentiation have the potential to be redox sensors. We highlight herein the importance of redox regulation of these key regulators in stem cell self-renewal and differentiation. Understanding the mechanisms of redox regulation in stem cell self-renewal and differentiation will open exciting new perspectives for stem cell biology. This article is part of a Special Issue entitled Redox regulation of differentiation and de-differentiation. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Renewal processes

    CERN Document Server

    Mitov, Kosto V

    2014-01-01

    This monograph serves as an introductory text to classical renewal theory and some of its applications for graduate students and researchers in mathematics and probability theory. Renewal processes play an important part in modeling many phenomena in insurance, finance, queuing systems, inventory control and other areas. In this book, an overview of univariate renewal theory is given and renewal processes in the non-lattice and lattice case are discussed. A pre-requisite is a basic knowledge of probability theory.

  7. Energy Production System Management - Renewable energy power supply integration with Building Automation System

    International Nuclear Information System (INIS)

    Figueiredo, Joao; Martins, Joao

    2010-01-01

    Intelligent buildings, historically and technologically, refers to the integration of four distinctive systems: Building Automation Systems (BAS), Telecommunication Systems, Office Automation Systems and Computer Building Management Systems. The increasing sophisticated BAS has become the 'heart and soul' of modern intelligent buildings. Integrating energy supply and demand elements - often known as Demand-Side Management (DSM) - has became an important energy efficiency policy concept. Nowadays, European countries have diversified their power supplies, reducing the dependence on OPEC, and developing a broader mix of energy sources maximizing the use of renewable energy domestic sources. In this way it makes sense to include a fifth system into the intelligent building group: Energy Production System Management (EPSM). This paper presents a Building Automation System where the Demand-Side Management is fully integrated with the building's Energy Production System, which incorporates a complete set of renewable energy production and storage systems.

  8. Characterization of Hybrid Systems for Rural Electrification with Renewable Energies Using Geographic Information Systems (GIS)

    Energy Technology Data Exchange (ETDEWEB)

    Borda Angel, J. P.; Dominguez, J.; Amador, J.; Arribas, L.; Pinedo Pascua, I.

    2011-07-01

    The objective of this project is to redefine the algorithm of wind-diesel hybrid system implemented in IntiGIS. This methodology was developed by CIEMAT for the evaluation of rural electrification projects, comparing different renewable and conventional technologies based on their LEC or equivalent electrification cost. The analysis considers the social and geographical particularities of the study area. The core of the new model is the definition of renewable fraction in the wind-diesel hybrid system. To this end, it was assumed that the fraction of renewable will depend, first of all, of the wind speed. In this case, the objectives were to find a relationship between the renewable fraction and wind speed, expressed as a function, and also trying to demonstrate the influence of other parameters such as fuel price and consumption. The methodology used to achieve these objectives was to use HOMER to simulate technology and size of system components in order to obtain the optimal fraction renewable scenarios. Next, we examined how it varied with wind speed; we assessed the influence of other parameters and, finally, it is represented as a function of wind speed. After the redefinition of the algorithm, the changes were planned for inclusion in IntiGIS and tests were performed to validate the new model. (Author)

  9. Analysis of a hybrid renewable energy system on the Mures valley using Homer

    Directory of Open Access Journals (Sweden)

    Dumitru Cristian Dragoş

    2011-12-01

    Full Text Available Renewable energy technologies offer the promise of clean, abundant energy gathered from self-renewing resources such as the sun, wind, earth, and plants. Virtually all regions of the world have renewable resources of one type or another. This paper deals with the modeling and analysis of a hybrid system based on renewable energy resources, located on the Mureş valley, using a dedicated software named HOMER. Different types and topologies of renewable resources for the energy supply are analyzed; a small consumer situated on the Mureş Valley is modeled based on a load curve. Finally, the energy flows between the renewable energy system and the local supplying network are analyzed.

  10. The Evolution of Power System Planning with High Levels of Variable Renewable Generation

    Energy Technology Data Exchange (ETDEWEB)

    Katz, Jessica [National Renewable Energy Lab. (NREL), Golden, CO (United States); Milligan, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-09-01

    Greening the Grid provides technical assistance to energy system planners, regulators, and grid operators to overcome challenges associated with integrating variable renewable energy into the grid. This document, part of the Greening the Grid introduces the evolution of power system planning with high levels of variable renewable generation.

  11. Nrf2 is required to maintain the self-renewal of glioma stem cells

    International Nuclear Information System (INIS)

    Zhu, Jianhong; Wang, Handong; Sun, Qing; Ji, Xiangjun; Zhu, Lin; Cong, Zixiang; Zhou, Yuan; Liu, Huandong; Zhou, Mengliang

    2013-01-01

    Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioma stem cells (GSCs). Self-renewal is a complex biological process necessary for maintaining the glioma stem cells. Nuclear factor rythroid 2-related factor 2(Nrf2) plays a significant role in protecting cells from endogenous and exogenous stresses. Nrf2 is a key nuclear transcription factor that regulates antioxidant response element (ARE)-containing genes. Previous studies have demonstrated the significant role of Nrf2 in the proliferation of glioblastoma, and in their resistance to radioactive therapies. We examined the effect of knocking down Nrf2 in GSCs. Nrf2 expression was down-regulated by shRNA transinfected with lentivirus. Expression levels of Nestin, Nrf2, BMI-1, Sox2 and Cyclin E were assessed by western blotting, quantitative polymerase chain reaction (qPCR) and immunohistochemistry analysis. The capacity for self-renewal in vitro was assessed by genesis of colonies. The capacity for self-renewal in vivo was analyzed by tumor genesis of xenografts in nude mice. Knockdown of Nrf2 inhibited the proliferation of GSCs, and significantly reduced the expression of BMI-1, Sox2 and CyclinE. Knocking down of Nrf2 changed the cell cycle distribution of GSCs by causing an uncharacteristic increase in the proportion of cells in the G2 phase and a decrease in the proportion of cells in the S phase of the cell cycle. Nrf2 is required to maintain the self-renewal of GSCs, and its down-regulation can attenuate the self-renewal of GSCs significantly

  12. A renewables-based South African energy system?

    CSIR Research Space (South Africa)

    Bischof-Niemz, T

    2015-12-01

    Full Text Available in electricity mix from 75 to 50% by 2025 That's a reduction by 140 TWh/yr of nuclear power generation, which is the same amount of energy produced by 10 Koebergs This energy will be replaced by renewables This emphasises again the recently achieved cost...-competitiveness of renewableshttp://www.world-nuclear-news.org/NP-French- energy-transition-bill-adopted-2307155.html 8Agenda International context Renewables in South Africa Extreme renewables scenarios 9Integrated Resource Plan 2010 (IRP 2010): Plan of the power generation mix...

  13. Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1

    Science.gov (United States)

    Ye, Shoudong; Li, Ping; Tong, Chang; Ying, Qi-Long

    2013-01-01

    Mouse embryonic stem cell (mESC) self-renewal can be maintained by activation of the leukaemia inhibitory factor (LIF)/signal transducer and activator of transcription 3 (Stat3) signalling pathway or dual inhibition (2i) of glycogen synthase kinase 3 (Gsk3) and mitogen-activated protein kinase kinase (MEK). Several downstream targets of the pathways involved have been identified that when individually overexpressed can partially support self-renewal. However, none of these targets is shared among the involved pathways. Here, we show that the CP2 family transcription factor Tfcp2l1 is a common target in LIF/Stat3- and 2i-mediated self-renewal, and forced expression of Tfcp2l1 can recapitulate the self-renewal-promoting effect of LIF or either of the 2i components. In addition, Tfcp2l1 can reprogram post-implantation epiblast stem cells to naïve pluripotent ESCs. Tfcp2l1 upregulates Nanog expression and promotes self-renewal in a Nanog-dependent manner. We conclude that Tfcp2l1 is at the intersection of LIF- and 2i-mediated self-renewal pathways and plays a critical role in maintaining ESC identity. Our study provides an expanded understanding of the current model of ground-state pluripotency. PMID:23942238

  14. Impacts of Renewable Energy Quota System on China's Future Power Sector

    OpenAIRE

    Xiong, Weiming; Zhang, Da; Mischke, Peggy; Zhang, Xiliang

    2014-01-01

    As the biggest carbon emitting sector which produces 44% of current national carbon emission in China, the coal-dominated power sector has a tremendous potential for CO2 mitigation in the next two decades. Renewable energy quota system is currently discussed as a potential future policy instrument for the power sector, which requires certain fraction of renewable energy in total power generation for each province and grid zone. The quantitative studies on renewable energy quota for China are ...

  15. [Tricostantin A inhibits self-renewal of breast cancer stem cells in vitro].

    Science.gov (United States)

    Peng, Li; Li, Fu-Xi; Shao, Wen-Feng; Xiong, Jing-Bo

    2013-10-01

    To investigate the effect of tricostantin A (TSA) on self-renewal of breast cancer stem cells and explore the mechanisms. Breast cancer cell lines MDA-MB-468, MDA-MB-231, MCF-7 and SKBR3 were cultured in suspension and treated with different concentrations of TSA for 7 days, using 0.1% DMSO as the control. Secondary mammosphere formation efficiency and percentage of CD44(+)/CD24(-) sub-population in the primary mammospheres were used to evaluate the effects of TSA on self-renewal of breast cancer stem cells. The breast cancer stem cell surface marker CD44(+)/CD24(-) and the percentage of apoptosis in the primary mammospheres were assayed using flow cytometry. The mRNA expressions of Nanog, Sox2 and Oct4 in the primary mammospheres were assayed with quantitative PCR. TSA at both 100 and 500 nmol/L, but not at 10 nmol/L, partially inhibited the self-renewal of breast cancer stem cells from the 4 cell lines. TSA at 500 nmol/L induced cell apoptosis in the primary mammospheres. TSA down-regulated the mRNA expression of Nanog and Sox2 in the primary mammospheres. TSA can partially inhibit the self-renewal of breast cancer stem cells through a mechanism involving the down-regulation of Nanog and Sox2 expression, indicating the value of combined treatments with low-dose TSA and other anticancer drugs to achieve maximum inhibition of breast cancer stem cell self-renewal. The core transcriptional factor of embryonic stem cells Nanog and Sox2 can be potential targets of anticancer therapy.

  16. The first step towards a 100% renewable energy-system for Ireland

    International Nuclear Information System (INIS)

    Connolly, D.; Leahy, M.; Lund, H.; Mathiesen, B.V.

    2011-01-01

    In 2007 Ireland supplied 96% of the total energy demand with fossil fuels (7% domestic and 89% imported) and 3% with renewable energy, even though there are enough renewable resources to supply all the energy required. As energy prices increase and the effects of global warming worsen, it is essential that Ireland begins to utilise its renewable resources more effectively. Therefore, this study presents the first step towards a 100% renewable energy-system for Ireland. The energy-system analysis tool used was EnergyPLAN, as it accounts for all sectors of the energy-system that need to be considered when integrating large penetrations of renewable energy: the electricity, heat, and transport sectors. Initially, a reference model of the existing Irish energy-system was constructed, and subsequently three different 100% renewable energy-systems were created with each focusing on a different resource: biomass, hydrogen, and electricity. These energy-systems were compared so that the benefits from each could be used to create an 'optimum' scenario called combination. Although the results illustrate a potential 100% renewable energy-system for Ireland, they have been obtained based on numerous assumptions. Therefore, these will need to be improved in the future before a serious roadmap can be defined for Ireland's renewable energy transition. (author)

  17. A 100% renewable energy system in the year 2050: The case of Macedonia

    International Nuclear Information System (INIS)

    Ćosić, Boris; Krajačić, Goran; Duić, Neven

    2012-01-01

    The most important problems the energy sector faces in Macedonia are an unfavourable energy mix with a high prevalence of lignite, a strong dependence on energy import, poor condition of the energy system and inefficiency in energy production and use. This paper investigates the prospects for realization of the 100% renewable energy system in Macedonia by making use of the EnergyPLAN model. Analysis was conducted for two renewable scenarios designed for the years 2030 and 2050. First scenario, the 50% renewable energy system, has been created for the year 2030 and represents the first step towards the 100% renewable energy future of Macedonia. The second scenario has been designed for the 100% renewable energy system based only on the renewable energy sources (RES) in the year 2050. Special attention in the design of these systems has been given to intermittent RES and to storage technologies. The analysis reveals that at the moment the 50% renewable energy system seems much more likely than the 100% renewable energy system, but with additional energy efficiency measures, which will lead to a decrease of consumption and with installation of new generation capacities this goal can be easily achieved.

  18. RE-Europe, a large-scale dataset for modeling a highly renewable European electricity system

    Science.gov (United States)

    Jensen, Tue V.; Pinson, Pierre

    2017-11-01

    Future highly renewable energy systems will couple to complex weather and climate dynamics. This coupling is generally not captured in detail by the open models developed in the power and energy system communities, where such open models exist. To enable modeling such a future energy system, we describe a dedicated large-scale dataset for a renewable electric power system. The dataset combines a transmission network model, as well as information for generation and demand. Generation includes conventional generators with their technical and economic characteristics, as well as weather-driven forecasts and corresponding realizations for renewable energy generation for a period of 3 years. These may be scaled according to the envisioned degrees of renewable penetration in a future European energy system. The spatial coverage, completeness and resolution of this dataset, open the door to the evaluation, scaling analysis and replicability check of a wealth of proposals in, e.g., market design, network actor coordination and forecasting of renewable power generation.

  19. RE-Europe, a large-scale dataset for modeling a highly renewable European electricity system.

    Science.gov (United States)

    Jensen, Tue V; Pinson, Pierre

    2017-11-28

    Future highly renewable energy systems will couple to complex weather and climate dynamics. This coupling is generally not captured in detail by the open models developed in the power and energy system communities, where such open models exist. To enable modeling such a future energy system, we describe a dedicated large-scale dataset for a renewable electric power system. The dataset combines a transmission network model, as well as information for generation and demand. Generation includes conventional generators with their technical and economic characteristics, as well as weather-driven forecasts and corresponding realizations for renewable energy generation for a period of 3 years. These may be scaled according to the envisioned degrees of renewable penetration in a future European energy system. The spatial coverage, completeness and resolution of this dataset, open the door to the evaluation, scaling analysis and replicability check of a wealth of proposals in, e.g., market design, network actor coordination and forecasting of renewable power generation.

  20. Liquid fuels from renewable resources in Canada: systems economics studies

    National Research Council Canada - National Science Library

    Osler, C. F

    1978-01-01

    This paper highlights the methodology and results of a six volume study completed for the Canadian government on alternatives for liquid fuel production from renewable resources after the mid-1980s...

  1. A hybrid renewable energy system for a North American off-grid community

    International Nuclear Information System (INIS)

    Rahman, Md. Mustafizur; Khan, Md. Mohib-Ul-Haque; Ullah, Mohammad Ahsan; Zhang, Xiaolei; Kumar, Amit

    2016-01-01

    Canada has many isolated communities that are not connected to the electrical grid. Most of these communities meet their electricity demand through stand-alone diesel generators. Diesel generators have economic and environmental concerns that can be minimized by using hybrid renewable energy technologies. This study aims to assess the implementation of a hybrid energy system for an off-grid community in Canada and to propose the best hybrid energy combination to reliably satisfy electricity demand. Seven scenarios were developed: 1) 100% renewable resources, 2) 80% renewable resources, 3) 65% renewable resources, 4) 50% renewable resources, 5) 35% renewable resources, 6) 21% renewable resources, and 7) battery-diesel generators (0% renewable resources). A case study for the remote community of Sandy Lake, Ontario, was conducted. Hybrid systems were chosen to meet the requirements of a 4.4 MWh/day primary load with a 772 kW peak load. Sensitivity analyses were carried out to assess the impact of solar radiation, wind speed, diesel price, CO 2 penalty cost, and project interest rate on optimum results. A GHG (greenhouse gas) abatement cost was assessed for each scenario. Considering GHG emission penalty cost, the costs of electricity for the seven scenarios are $1.48/kWh, $0.62/kWh, $0.54/kWh, $0.42/kWh, $0.39/kWh, $0.37/kWh, and $0.36/kWh. - Highlights: • Modeling of hybrid renewable energy systems for an off-grid community. • Seven scenarios were developed based on various renewable energy fractions. • Cost of electricity is the highest for 100% renewable fraction scenario. • CO 2 emissions are reduced by 1232 tonnes/yr by switching from diesel to renewables. • The electricity cost is most sensitive to diesel price based on sensitivity analysis.

  2. Renewable building energy systems and passive human comfort solutions

    Energy Technology Data Exchange (ETDEWEB)

    Omer, Abdeen Mustafa [17 Juniper Court, Forest Road West, Nottingham NG7 4EU (United Kingdom)

    2008-08-15

    With environmental protection posing as the number one global problem, man has no choice but to reduce his energy consumption. One way to accomplish this is to resort to passive and low-energy systems to maintain thermal comfort in buildings. The conventional and modern designs of wind towers can successfully be used in hot arid regions to maintain thermal comfort (with or without the use of ceiling fans) during all hours of the cooling season, or a fraction of it. Climatic design is one of the best approaches to reduce the energy cost in buildings. Proper design is the first step of defence against the stress of the climate. Buildings should be designed according to the climate of the site, reducing the need for mechanical heating or cooling. Hence maximum natural energy can be used for creating a pleasant environment inside the built envelope. Technology and industry progress in the last decade diffused electronic and informatics' devices in many human activities, and also in building construction. The utilisation and operating opportunities components, increase the reduction of heat losses by varying the thermal insulation, optimise the lighting distribution with louver screens and operate mechanical ventilation for coolness in indoor spaces. In addition to these parameters the intelligent envelope can act for security control and became an important part of the building domotic revolution. Application of simple passive cooling measure is effective in reducing the cooling load of buildings in hot and humid climates. Fourty-three percent reductions can be achieved using a combination of well-established technologies such as glazing, shading, insulation, and natural ventilation. More advanced passive cooling techniques such as roof pond, dynamic insulation, and evaporative water jacket need to be considered more closely. The building sector is a major consumer of both energy and materials worldwide, and that consumption is increasing. Most industrialised

  3. Design, engineering, and construction of photosynthetic microbial cell factories for renewable solar fuel production.

    Science.gov (United States)

    Lindblad, Peter; Lindberg, Pia; Oliveira, Paulo; Stensjö, Karin; Heidorn, Thorsten

    2012-01-01

    There is an urgent need to develop sustainable solutions to convert solar energy into energy carriers used in the society. In addition to solar cells generating electricity, there are several options to generate solar fuels. This paper outlines and discusses the design and engineering of photosynthetic microbial systems for the generation of renewable solar fuels, with a focus on cyanobacteria. Cyanobacteria are prokaryotic microorganisms with the same type of photosynthesis as higher plants. Native and engineered cyanobacteria have been used by us and others as model systems to examine, demonstrate, and develop photobiological H(2) production. More recently, the production of carbon-containing solar fuels like ethanol, butanol, and isoprene have been demonstrated. We are using a synthetic biology approach to develop efficient photosynthetic microbial cell factories for direct generation of biofuels from solar energy. Present progress and advances in the design, engineering, and construction of such cyanobacterial cells for the generation of a portfolio of solar fuels, e.g., hydrogen, alcohols, and isoprene, are presented and discussed. Possibilities and challenges when introducing and using synthetic biology are highlighted.

  4. Design, Engineering, and Construction of Photosynthetic Microbial Cell Factories for Renewable Solar Fuel Production

    Energy Technology Data Exchange (ETDEWEB)

    Lindblad, Peter; Lindberg, Pia; Stensjoe, Karin (Photochemistry and Molecular Science, Dept. of Chemistry-Aangstroem Laboratory, Uppsala Univ., Uppsala (Sweden)), E-mail: Peter.Lindblad@kemi.uu.se; Oliveira, Paulo (Instituto de Biologia Molecular e Celular, Porto (Portugal)); Heidorn, Thorsten (Bioforsk-Norwegian Inst. for Agricultural and Environmental Research, Aas Oslo, (Norway))

    2012-03-15

    There is an urgent need to develop sustainable solutions to convert solar energy into energy carriers used in the society. In addition to solar cells generating electricity, there are several options to generate solar fuels. This paper outlines and discusses the design and engineering of photosynthetic microbial systems for the generation of renewable solar fuels, with a focus on cyanobacteria. Cyanobacteria are prokaryotic microorganisms with the same type of photosynthesis as higher plants. Native and engineered cyanobacteria have been used by us and others as model systems to examine, demonstrate, and develop photobiological H{sub 2} production. More recently, the production of carbon-containing solar fuels like ethanol, butanol, and isoprene have been demonstrated. We are using a synthetic biology approach to develop efficient photosynthetic microbial cell factories for direct generation of biofuels from solar energy. Present progress and advances in the design, engineering, and construction of such cyanobacterial cells for the generation of a portfolio of solar fuels, e.g., hydrogen, alcohols, and isoprene, are presented and discussed. Possibilities and challenges when introducing and using synthetic biology are highlighted

  5. A theoretical study of rotatable renewable energy system for stratospheric airship

    International Nuclear Information System (INIS)

    Lv, Mingyun; Li, Jun; Zhu, Weiyu; Du, Huafei; Meng, Junhui; Sun, Kangwen

    2017-01-01

    Highlights: • A new rotatable renewable energy system is designed for stratospheric airship. • A theoretical model of optimal rotation angle and required area are studied. • The effects of latitude and date on output energy per day are investigated. • The advantages of the rotatable renewable energy system are studied. - Abstract: Renewable energy system is very critical for solving the energy problem of a long endurance stratospheric airship. Output performance of the traditional solar array fixed on the upper surface of the airship remains to be improved to reduce the area and weight of renewable energy system. Inspired by the solar tracking system and kirigami, a rotatable renewable energy system (mainly including solar array) is designed to improve the current status of the energy system. The advantages of the rotatable solar array are studied using a MATLAB computer program based on the theoretical model established in this paper. The improvements in output energy and required area of the solar array were compared between the traditional airship and improved one. Studies had shown that the rotatable renewable energy system made the total weight of energy system decreased by 1000 kg when the maximum design speed of the airship was greater than 22 m/s. The results demonstrate that the rotatable renewable energy system for the airship can be a good way to improve the output performance of solar array, and the conceptual design and theoretical model suggest a pathway towards solving the energy problem of a stratospheric airship.

  6. Metering systems and demand-side management models applied to hybrid renewable energy systems in micro-grid configuration

    International Nuclear Information System (INIS)

    Blasques, L.C.M.; Pinho, J.T.

    2012-01-01

    This paper proposes a demand-side management model integrated to a metering system for hybrid renewable energy systems in micro-grid configuration. The proposal is based on the management problems verified in most of this kind of renewable hybrid systems installed in Brazil. The main idea is the implementation of a pre-paid metering system with some control functions that directly act on the consumer demand, restricting the consumption proportionally to the monthly availability of renewable energy. The result is a better distribution of the electricity consumption by month and by consumer, preventing that only one user, with larger purchasing power, consumes all the renewable energy available at some time period. The proportionality between the consumption and the renewable energy's availability has the objective to prevent a lack of energy stored and a high use of the diesel generator-set on months of low renewable potential. This paper also aims to contribute to the Brazilian regulation of renewable energy systems supplying micro-grids. - Highlights: ► Review of the Brazilian electricity regulation for small-scale isolated systems. ► Renewable systems are the most feasible option in several isolated communities. ► One proposal is to guarantee government subsidies for renewable energy systems. ► Smart electronic meters to create electricity restrictions for the consumers.

  7. Nuclear Energy and Renewables. System Effects in Low-carbon Electricity Systems - Executive Summary

    International Nuclear Information System (INIS)

    2012-01-01

    This report addresses the increasingly important interactions of variable renewables and dispatchable energy technologies, such as nuclear power, in terms of their effects on electricity systems. These effects add costs to the production of electricity, which are not usually transparent. The report recommends that decision-makers should take into account such system costs and internalise them according to a 'generator pays' principle, which is currently not the case. Analysing data from six OECD/NEA countries, the study finds that including the system costs of variable renewables at the level of the electricity grid increases the total costs of electricity supply by up to one-third, depending on technology, country and penetration levels. In addition, it concludes that, unless the current market subsidies for renewables are altered, dispatchable technologies will increasingly not be replaced as they reach their end of life and consequently security of supply will suffer. This implies that significant changes in management and cost allocation will be needed to generate the flexibility required for an economically viable coexistence of nuclear energy and renewables in increasingly de-carbonised electricity systems. (authors)

  8. REST controls self-renewal and tumorigenic competence of human glioblastoma cells.

    Directory of Open Access Journals (Sweden)

    Luciano Conti

    Full Text Available The Repressor Element 1 Silencing Transcription factor (REST/NRSF is a master repressor of neuronal programs in non-neuronal lineages shown to function as a central regulator of developmental programs and stem cell physiology. Aberrant REST function has been associated with a number of pathological conditions. In cancer biology, REST has been shown to play a tumor suppressor activity in epithelial cancers but an oncogenic role in brain childhood malignancies such as neuroblastoma and medulloblastoma. Here we examined REST expression in human glioblastoma multiforme (GBM specimens and its role in GBM cells carrying self-renewal and tumorigenic competence. We found REST to be expressed in GBM specimens, its presence being particularly enriched in tumor cells in the perivascular compartment. Significantly, REST is highly expressed in self-renewing tumorigenic-competent GBM cells and its knock down strongly reduces their self-renewal in vitro and tumor-initiating capacity in vivo and affects levels of miR-124 and its downstream targets. These results indicate that REST contributes to GBM maintenance by affecting its self-renewing and tumorigenic cellular component and that, hence, a better understanding of these circuitries in these cells might lead to new exploitable therapeutic targets.

  9. Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal

    Science.gov (United States)

    Chandrakesan, Parthasarathy; May, Randal; Qu, Dongfeng; Weygant, Nathaniel; Taylor, Vivian E.; Li, James D.; Ali, Naushad; Sureban, Sripathi M.; Qante, Michael; Wang, Timothy C.; Bronze, Michael S.; Houchen, Courtney W.

    2015-01-01

    To date, no discrete genetic signature has been defined for isolated Dclk1+ tuft cells within the small intestine. Furthermore, recent reports on the functional significance of Dclk1+ cells in the small intestine have been inconsistent. These cells have been proposed to be fully differentiated cells, reserve stem cells, and tumor stem cells. In order to elucidate the potential function of Dclk1+ cells, we FACS-sorted Dclk1+ cells from mouse small intestinal epithelium using transgenic mice expressing YFP under the control of the Dclk1 promoter (Dclk1-CreER;Rosa26-YFP). Analysis of sorted YFP+ cells demonstrated marked enrichment (~6000 fold) for Dclk1 mRNA compared with YFP− cells. Dclk1+ population display ~6 fold enrichment for the putative quiescent stem cell marker Bmi1. We observed significantly greater expression of pluripotency genes, pro-survival genes, and quiescence markers in the Dclk1+ population. A significant increase in self-renewal capability (14-fold) was observed in in vitro isolated Dclk1+ cells. The unique genetic report presented in this manuscript suggests that Dclk1+ cells may maintain quiescence, pluripotency, and metabolic activity for survival/longevity. Functionally, these reserve characteristics manifest in vitro, with Dclk1+ cells exhibiting greater ability to self-renew. These findings indicate that quiescent stem-like functionality is a feature of Dclk1-expressing tuft cells. PMID:26362399

  10. Modeling the power of renewable energy sources in the context of classical electricity system transformation

    Directory of Open Access Journals (Sweden)

    Rafał Kasperowicz

    2017-10-01

    Full Text Available Many regions, not only in the Europe, introduce plans for the modernization of energy systems so that in a few or several years most of the demand for electricity was being able to cover using renewable energy sources. The aim of this paper is to present the possibility of estimation of appropriate power supply based on the renewable energy sources in the context of the whole energy system in the annual balance, taking into account the technical and the economic optimization strategies. The article presents also the simplified structure of the 100% renewable energy system supported by energy storage systems and the production of synthetic fuels.

  11. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.

    Directory of Open Access Journals (Sweden)

    Stephen N Sansom

    2009-06-01

    Full Text Available Neural stem cell self-renewal, neurogenesis, and cell fate determination are processes that control the generation of specific classes of neurons at the correct place and time. The transcription factor Pax6 is essential for neural stem cell proliferation, multipotency, and neurogenesis in many regions of the central nervous system, including the cerebral cortex. We used Pax6 as an entry point to define the cellular networks controlling neural stem cell self-renewal and neurogenesis in stem cells of the developing mouse cerebral cortex. We identified the genomic binding locations of Pax6 in neocortical stem cells during normal development and ascertained the functional significance of genes that we found to be regulated by Pax6, finding that Pax6 positively and directly regulates cohorts of genes that promote neural stem cell self-renewal, basal progenitor cell genesis, and neurogenesis. Notably, we defined a core network regulating neocortical stem cell decision-making in which Pax6 interacts with three other regulators of neurogenesis, Neurog2, Ascl1, and Hes1. Analyses of the biological function of Pax6 in neural stem cells through phenotypic analyses of Pax6 gain- and loss-of-function mutant cortices demonstrated that the Pax6-regulated networks operating in neural stem cells are highly dosage sensitive. Increasing Pax6 levels drives the system towards neurogenesis and basal progenitor cell genesis by increasing expression of a cohort of basal progenitor cell determinants, including the key transcription factor Eomes/Tbr2, and thus towards neurogenesis at the expense of self-renewal. Removing Pax6 reduces cortical stem cell self-renewal by decreasing expression of key cell cycle regulators, resulting in excess early neurogenesis. We find that the relative levels of Pax6, Hes1, and Neurog2 are key determinants of a dynamic network that controls whether neural stem cells self-renew, generate cortical neurons, or generate basal progenitor cells

  12. A High-Efficiency Voltage Equalization Scheme for Supercapacitor Energy Storage System in Renewable Generation Applications

    Directory of Open Access Journals (Sweden)

    Liran Li

    2016-06-01

    Full Text Available Due to its fast charge and discharge rate, a supercapacitor-based energy storage system is especially suitable for power smoothing in renewable energy generation applications. Voltage equalization is essential for series-connected supercapacitors in an energy storage system, because it supports the system’s sustainability and maximizes the available cell energy. In this paper, we present a high-efficiency voltage equalization scheme for supercapacitor energy storage systems in renewable generation applications. We propose an improved isolated converter topology that uses a multi-winding transformer. An improved push-pull forward circuit is applied on the primary side of the transformer. A coupling inductor is added on the primary side to allow the switches to operate under the zero-voltage switching (ZVS condition, which reduces switching losses. The diodes in the rectifier are replaced with metal-oxide-semiconductor field-effect transistors (MOSFETs to reduce the power dissipation of the secondary side. In order to simplify the control, we designed a controllable rectifying circuit to achieve synchronous rectifying on the secondary side of the transformer. The experimental results verified the effectiveness of the proposed design.

  13. The p53 inhibitor, pifithrin-{alpha}, suppresses self-renewal of embryonic stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Abdelalim, Essam Mohamed, E-mail: essam_abdelalim@yahoo.com [Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192 (Japan); Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522 (Egypt); Tooyama, Ikuo [Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192 (Japan)

    2012-04-13

    Highlights: Black-Right-Pointing-Pointer We determine the role of p53 in ES cells under unstressful conditions. Black-Right-Pointing-Pointer PFT-{alpha} suppresses ES cell proliferation. Black-Right-Pointing-Pointer PFT-{alpha} induces ES cell cycle arrest. Black-Right-Pointing-Pointer PFT-{alpha} downregulates Nanog and cyclin D1. -- Abstract: Recent studies have reported the role of p53 in suppressing the pluripotency of embryonic stem (ES) cells after DNA damage and blocking the reprogramming of somatic cells into induced pluripotent stem (iPS) cells. However, to date no evidence has been presented to support the function of p53 in unstressed ES cells. In this study, we investigated the effect of pifithrin (PFT)-{alpha}, an inhibitor of p53-dependent transcriptional activation, on self-renewal of ES cells. Our results revealed that treatment of ES cells with PFT-{alpha} resulted in the inhibition of ES cell propagation in a dose-dependent manner, as indicated by a marked reduction in the cell number and colony size. Also, PFT-{alpha} caused a cell cycle arrest and significant reduction in DNA synthesis. In addition, inhibition of p53 activity reduced the expression levels of cyclin D1 and Nanog. These findings indicate that p53 pathway in ES cells rather than acting as an inactive gene, is required for ES cell proliferation and self-renewal under unstressful conditions.

  14. The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells

    International Nuclear Information System (INIS)

    Abdelalim, Essam Mohamed; Tooyama, Ikuo

    2012-01-01

    Highlights: ► We determine the role of p53 in ES cells under unstressful conditions. ► PFT-α suppresses ES cell proliferation. ► PFT-α induces ES cell cycle arrest. ► PFT-α downregulates Nanog and cyclin D1. -- Abstract: Recent studies have reported the role of p53 in suppressing the pluripotency of embryonic stem (ES) cells after DNA damage and blocking the reprogramming of somatic cells into induced pluripotent stem (iPS) cells. However, to date no evidence has been presented to support the function of p53 in unstressed ES cells. In this study, we investigated the effect of pifithrin (PFT)-α, an inhibitor of p53-dependent transcriptional activation, on self-renewal of ES cells. Our results revealed that treatment of ES cells with PFT-α resulted in the inhibition of ES cell propagation in a dose-dependent manner, as indicated by a marked reduction in the cell number and colony size. Also, PFT-α caused a cell cycle arrest and significant reduction in DNA synthesis. In addition, inhibition of p53 activity reduced the expression levels of cyclin D1 and Nanog. These findings indicate that p53 pathway in ES cells rather than acting as an inactive gene, is required for ES cell proliferation and self-renewal under unstressful conditions.

  15. Ovarian Stem Cell Niche and Follicular Renewal in Mammals

    Czech Academy of Sciences Publication Activity Database

    Bukovský, Antonín

    2011-01-01

    Roč. 294, č. 8 (2011), s. 1284-1306 ISSN 1932-8486 Institutional research plan: CEZ:AV0Z50520701 Keywords : ovary * stem cell niche * neo-oogenesis Subject RIV: EA - Cell Biology Impact factor: 1.473, year: 2011

  16. Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms.

    Science.gov (United States)

    Ma, Xing; Zhu, Xiujuan; Han, Yingying; Story, Benjamin; Do, Trieu; Song, Xiaoqing; Wang, Su; Zhang, Ying; Blanchette, Marco; Gogol, Madelaine; Hall, Kate; Peak, Allison; Anoja, Perera; Xie, Ting

    2017-04-24

    Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear whether it plays any roles in early GSC lineage development. Here we report that Aub promotes GSC self-renewal and GSC progeny differentiation. RNA-iCLIP results show that Aub binds the mRNAs encoding self-renewal and differentiation factors in cultured GSCs. Aub controls GSC self-renewal by preventing DNA-damage-induced Chk2 activation and by translationally controlling the expression of self-renewal factors. It promotes GSC progeny differentiation by translationally controlling the expression of differentiation factors, including Bam. Therefore, this study reveals a function of Aub in GSCs and their progeny, which promotes translation of self-renewal and differentiation factors by directly binding to its target mRNAs and interacting with translational initiation factors. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate

    Directory of Open Access Journals (Sweden)

    Sofia Baptista

    2014-09-01

    Full Text Available Methamphetamine (METH is a highly addictive psychostimulant drug of abuse that negatively interferes with neurogenesis. In fact, we have previously shown that METH triggers stem/progenitor cell death and decreases neuronal differentiation in the dentate gyrus (DG. Still, little is known regarding its effect on DG stem cell properties. Herein, we investigate the impact of METH on mice DG stem/progenitor cell self-renewal functions. METH (10 nM decreased DG stem cell self-renewal, while 1 nM delayed cell cycle in the G0/G1-to-S phase transition and increased the number of quiescent cells (G0 phase, which correlated with a decrease in cyclin E, pEGFR and pERK1/2 protein levels. Importantly, both drug concentrations (1 or 10 nM did not induce cell death. In accordance with the impairment of self-renewal capacity, METH (10 nM decreased Sox2+/Sox2+ while increased Sox2−/Sox2− pairs of daughter cells. This effect relied on N-methyl-d-aspartate (NMDA signaling, which was prevented by the NMDA receptor antagonist, MK-801 (10 μM. Moreover, METH (10 nM increased doublecortin (DCX protein levels consistent with neuronal differentiation. In conclusion, METH alters DG stem cell properties by delaying cell cycle and decreasing self-renewal capacities, mechanisms that may contribute to DG neurogenesis impairment followed by cognitive deficits verified in METH consumers.

  18. Lessons from a European study[Financing Renewable Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Langniss, Ole [German Aerospace Center, Stuttgart (Germany); Helby, Peter [Lund Univ. (Sweden). Dept. of Environmental and Energy System Studies

    2000-10-01

    A large number of proven technical solutions exists for the use of renewable energies (RE). However, their dissemination is still too slow to meet the political goal of substituting 12 % of the primary energy demand in the European Union by the year 2010. Even renewable energy systems (RES) with economic potential are only partly exploited. There is a long literature concerning the barriers to RE use. In particular it has become clear that the availability of finance and the forms and conditions upon which it is lent have a major impact on RE deployment. An area of importance is the deficiency of appropriate ownership forms and properly adapted financing instruments in certain countries. Moreover, different regulations and institutional barriers in the European countries hinder the free flow of capital for RES within the European common market. On the other hand, solutions have been developed very successfully in individual countries. Differences in cultures and institutions have promoted growth of several approaches to RE investment. These differences can be understood as a European source of experience that constitutes a rich basis for transnational emulation. The research project FIRE analysed and compared the means of financing RES in Austria, Denmark, Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom to put forward best practise recommendations so that RE deployments will occur at a faster rate. Main tasks of this study were to analyse the means of financing RES in a number of countries; to provide an analysis of best practise; and to provide an analysis of the barriers to the implementation in the investigated countries. Different means of financing RES were analysed in relation to the country-specific environment. This included exogenous conditions such as tax aspects, legal restrictions and subsidies, as well as individually defined risk management strategies and collateral requirements. Eight in-depth-case studies were undertaken for

  19. Outlook and application analysis of energy storage in power system with high renewable energy penetration

    Science.gov (United States)

    Feng, Junshu; Zhang, Fuqiang

    2018-02-01

    To realize low-emission and low-carbon energy production and consumption, large-scale development and utilization of renewable energy has been put into practice in China. And it has been recognized that power system of future high renewable energy shares can operate more reliably with the participation of energy storage. Considering the significant role of storage playing in the future power system, this paper focuses on the application of energy storage with high renewable energy penetration. Firstly, two application modes are given, including demand side application mode and centralized renewable energy farm application mode. Afterwards, a high renewable energy penetration scenario of northwest region in China is designed, and its production simulation with application of energy storage in 2050 has been calculated and analysed. Finally, a development path and outlook of energy storage is given.

  20. Erk signaling suppresses embryonic stem cell self-renewal to specify endoderm

    DEFF Research Database (Denmark)

    Hamilton, William B; Brickman, Joshua M

    2014-01-01

    Fgf signaling via Erk activation has been associated with both neural induction and the generation of a primed state for the differentiation of embryonic stem cells (ESCs) to all somatic lineages. To dissect the role of Erk in both ESC self-renewal and lineage specification, we explored...

  1. Fuel Cell Power Plants Renewable and Waste Fuels

    Science.gov (United States)

    2011-01-13

    logo, Direct FuelCell and “DFC” are all registered trademarks (®) of FuelCell Energy, Inc. Applications •On-site self generation of combined heat... of FuelCell Energy, Inc. Fuels Resources for DFC • Natural Gas and LNG • Propane • Biogas (by Anaerobicnaerobic Digestion) - Municipal Waste...FUEL RESOURCES z NATURAL GAS z PROPANE z DFC H2 (50-60%) z ETHANOL zWASTE METHANE z BIOGAS z COAL GAS Diversity of Fuels plus High Efficiency

  2. Cross-border versus cross-sector interconnectivity in renewable energy systems

    DEFF Research Database (Denmark)

    Thellufsen, Jakob Zinck; Lund, Henrik

    2017-01-01

    . The results show that while both measures increase the system utilisation of renewable energy and the system efficiency, the cross-sector interconnection gives the best system performance. To analyse the possible interaction between cross-sector and cross-border interconnectivity, two main aspects have......In the transition to renewable energy systems, fluctuating renewable energy, such as wind and solar power, plays a large and important role. This creates a challenge in terms of meeting demands, as the energy production fluctuates based on weather patterns. To utilise high amounts of fluctuating...... renewable energy, the energy system has to be more flexible in terms of decoupling demand and production. This paper investigates two potential ways to increase flexibility. The first is the interconnection between energy systems, for instance between two countries, labelled as cross-border interconnection...

  3. Fuel Consumption Analysis and Optimization of a Sustainable Energy System for a 100% Renewables Smart House

    DEFF Research Database (Denmark)

    Craciun, Vasile Simion; Blarke, Morten; Trifa, Viorel

    2012-01-01

    and a feasibility study of a sustainable energy system for a 100% renewables smart house (SH) in Denmark is presented. Due to the continuous increasing penetration levels of wind and solar power in today’s energy system call for the development of high efficiency optimizations and Smart Grid (SG) enabling options....... In case of renewable energies, one main challenge is the discontinuity of generation which can be solved with planning and control optimization methods. The results of the economic analysis and the feasibility of the sustainable energy system for a 100% renewables SH show that this could be possible...

  4. System effects of nuclear energy and renewables in low-carbon electricity Systems

    International Nuclear Information System (INIS)

    Keppler, J.H.; Gameron, R.; Cometto, M.

    2012-01-01

    Electricity produced by variable renewable energies significantly affects the economics of dispatchable power generators, in particular those of nuclear power, both in the short run and the long run; the outcome of these competing factors will depend on the amount of variable renewables being introduced, local conditions and the level of carbon prices. An assessment of grid-level system costs (including the costs for grid connection, extension and reinforcement, as well as the added costs for balancing and back-up, but excluding the financial costs of intermittency and the impacts on security of supply, the environment, siting and safety), reveals a considerable difference between those of dispatchable technologies and those of variable renewables. Using a common methodology and a broad array of country-specific data, the grid-level system costs for Finland, France, Germany, the Republic of Korea, the United Kingdom and the United States were calculated for nuclear, coal, gas, onshore wind, offshore wind and solar PV both at 10 pc and 30 pc penetration levels. Variable renewables are creating a market environment in which dispatchable technologies can no longer finance themselves through revenues in 'energy only' wholesale markets; this has serious implications for the security of electricity supplies. Four main policy recommendations are proposed

  5. Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors.

    Science.gov (United States)

    Janssens, Derek H; Komori, Hideyuki; Grbac, Daniel; Chen, Keng; Koe, Chwee Tat; Wang, Hongyan; Lee, Cheng-Yu

    2014-03-01

    Despite expressing stem cell self-renewal factors, intermediate progenitor cells possess restricted developmental potential, which allows them to give rise exclusively to differentiated progeny rather than stem cell progeny. Failure to restrict the developmental potential can allow intermediate progenitor cells to revert into aberrant stem cells that might contribute to tumorigenesis. Insight into stable restriction of the developmental potential in intermediate progenitor cells could improve our understanding of the development and growth of tumors, but the mechanisms involved remain largely unknown. Intermediate neural progenitors (INPs), generated by type II neural stem cells (neuroblasts) in fly larval brains, provide an in vivo model for investigating the mechanisms that stably restrict the developmental potential of intermediate progenitor cells. Here, we report that the transcriptional repressor protein Earmuff (Erm) functions temporally after Brain tumor (Brat) and Numb to restrict the developmental potential of uncommitted (immature) INPs. Consistently, endogenous Erm is detected in immature INPs but undetectable in INPs. Erm-dependent restriction of the developmental potential in immature INPs leads to attenuated competence to respond to all known neuroblast self-renewal factors in INPs. We also identified that the BAP chromatin-remodeling complex probably functions cooperatively with Erm to restrict the developmental potential of immature INPs. Together, these data led us to conclude that the Erm-BAP-dependent mechanism stably restricts the developmental potential of immature INPs by attenuating their genomic responses to stem cell self-renewal factors. We propose that restriction of developmental potential by the Erm-BAP-dependent mechanism functionally distinguishes intermediate progenitor cells from stem cells, ensuring the generation of differentiated cells and preventing the formation of progenitor cell-derived tumor-initiating stem cells.

  6. Cellular automata and integrodifferential equation models for cell renewal in mosaic tissues

    Science.gov (United States)

    Bloomfield, J. M.; Sherratt, J. A.; Painter, K. J.; Landini, G.

    2010-01-01

    Mosaic tissues are composed of two or more genetically distinct cell types. They occur naturally, and are also a useful experimental method for exploring tissue growth and maintenance. By marking the different cell types, one can study the patterns formed by proliferation, renewal and migration. Here, we present mathematical modelling suggesting that small changes in the type of interaction that cells have with their local cellular environment can lead to very different outcomes for the composition of mosaics. In cell renewal, proliferation of each cell type may depend linearly or nonlinearly on the local proportion of cells of that type, and these two possibilities produce very different patterns. We study two variations of a cellular automaton model based on simple rules for renewal. We then propose an integrodifferential equation model, and again consider two different forms of cellular interaction. The results of the continuous and cellular automata models are qualitatively the same, and we observe that changes in local environment interaction affect the dynamics for both. Furthermore, we demonstrate that the models reproduce some of the patterns seen in actual mosaic tissues. In particular, our results suggest that the differing patterns seen in organ parenchymas may be driven purely by the process of cell replacement under different interaction scenarios. PMID:20375040

  7. The Potential of Renewable Energy Systems in China

    DEFF Research Database (Denmark)

    Liu, Wen; Lund, Henrik; Mathiesen, Brian Vad

    2009-01-01

    This paper discusses the prospective of renewable energy in the process of sustainable development in China. Along with the high-speed economic development and increasing energy consumption, the Chinese Government faces a growing pressure to maintain the balance between energy supply and demand a...

  8. 100% Renewable Energy Systems in Project Future Climate

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad

    2009-01-01

    Greenhouse gas mitigation strategies are generally considered costly with world leaders often engaging in debate concerning the costs of mitigation and the distribution of these costs between different countries. In this paper, the analyses and results of the design of a 100 per cent renewable en...

  9. Renewable energy systems for distributed generation in South Africa

    CSIR Research Space (South Africa)

    Szewczuk, S

    2010-10-01

    Full Text Available by the CSIR and its international partners, Garrad Hassan of the UK and the Netherlands Energy Research Foundation into the development of an analytical tool that could be used to assist in identifying viable renewable energy opportunities in areas...

  10. Hybrid systems to address seasonal mismatches between electricity production and demand in nuclear renewable electrical grids

    International Nuclear Information System (INIS)

    Forsberg, Charles

    2013-01-01

    A strategy to enable zero-carbon variable electricity production with full utilization of renewable and nuclear energy sources has been developed. Wind and solar systems send electricity to the grid. Nuclear plants operate at full capacity with variable steam to turbines to match electricity demand with production (renewables and nuclear). Excess steam at times of low electricity prices and electricity demand go to hybrid fuel production and storage systems. The characteristic of these hybrid technologies is that the economic penalties for variable nuclear steam inputs are small. Three hybrid systems were identified that could be deployed at the required scale. The first option is the gigawatt-year hourly-to-seasonal heat storage system where excess steam from the nuclear plant is used to heat rock a kilometer underground to create an artificial geothermal heat source. The heat source produces electricity on demand using geothermal technology. The second option uses steam from the nuclear plant and electricity from the grid with high-temperature electrolysis (HTR) cells to produce hydrogen and oxygen. Hydrogen is primarily for industrial applications; however, the HTE can be operated in reverse using hydrogen for peak electricity production. The third option uses variable steam and electricity for shale oil production. -- Highlights: •A system is proposed to meet variable hourly to seasonal electricity demand. •Variable solar and wind electricity sent to the grid. •Base-load nuclear plants send variable steam for electricity and hybrid systems. •Hybrid energy systems can economically absorb gigawatts of variable steam. •Hybrid systems include geothermal heat storage, hydrogen, and shale-oil production

  11. Design and Realization of Online Monitoring System of Distributed New Energy and Renewable Energy

    Science.gov (United States)

    Tang, Yanfen; Zhou, Tao; Li, Mengwen; Zheng, Guotai; Li, Hao

    2018-01-01

    Aimed at difficult centralized monitoring and management of current distributed new energy and renewable energy generation projects due to great varieties, different communication protocols and large-scale difference, this paper designs a online monitoring system of new energy and renewable energy characterized by distributed deployment, tailorable functions, extendible applications and fault self-healing performance. This system is designed based on international general standard for grid information data model, formulates unified data acquisition and transmission standard for different types of new energy and renewable energy generation projects, and can realize unified data acquisition and real-time monitoring of new energy and renewable energy generation projects, such as solar energy, wind power, biomass energy, etc. within its jurisdiction. This system has applied in Beijing. At present, 576 projects are connected to the system. Good effect is achieved and stability and reliability of the system have been validated.

  12. The effects of silver nanoparticles on mouse embryonic stem cell self-renewal and proliferation

    Directory of Open Access Journals (Sweden)

    Pavan Rajanahalli

    2015-01-01

    Full Text Available Silver nanoparticles (AgNPs are gaining rapid popularity in many commonly used medical and commercial products for their unique anti-bacterial properties. The molecular mechanisms of effects of AgNPs on stem cell self-renewal and proliferation have not yet been well understood. The aim of the work is to use mouse embryonic stem cells (mESCs as a cellular model to evaluate the toxicity of AgNPs. mESC is a very special cell type which has self-renewal and differentiation properties. The objective of this project is to determine the effects of AgNPs with different surface chemical compositions on the self-renewal and cell cycle of mESCs. Two different surface chemical compositions of AgNPs, polysaccharide-coated and hydrocarbon-coated, were used to test their toxic effects on self-renewal and proliferation of mESCs. The results indicated that both polysaccharide-coated and hydrocarbon-coated AgNPs changed the cell morphology of mESCs. Cell cycle analysis indicated that AgNPs induced mESCs cell cycle arrest at G1 and S phases through inhibition of the hyperphosphorylation of Retinoblastoma (Rb protein. Furthermore, AgNPs exposure reduced Oct4A isoform expression which is responsible for the pluripotency of mESCs, and induced the expression of several isoforms OCT4B-265, OCT4B-190, OCT4B-164 which were suggested involved in stem cell stresses responses. In addition, the evidence of reactive oxygen species (ROS production with two different surface chemical compositions of AgNPs supported our hypothesis that the toxic effect AgNPs exposure is due to overproduction of ROS which altered the gene expression and protein modifications. Polysaccharide coating reduced ROS production, and thus reduced the AgNPs toxicity.

  13. Hedgehog-GLI signaling drives self-renewal and tumorigenicity of human melanoma-initiating cells.

    Science.gov (United States)

    Santini, Roberta; Vinci, Maria C; Pandolfi, Silvia; Penachioni, Junia Y; Montagnani, Valentina; Olivito, Biagio; Gattai, Riccardo; Pimpinelli, Nicola; Gerlini, Gianni; Borgognoni, Lorenzo; Stecca, Barbara

    2012-09-01

    The question of whether cancer stem/tumor-initiating cells (CSC/TIC) exist in human melanomas has arisen in the last few years. Here, we have used nonadherent spheres and the aldehyde dehydrogenase (ALDH) enzymatic activity to enrich for CSC/TIC in a collection of human melanomas obtained from a broad spectrum of sites and stages. We find that melanomaspheres display extensive in vitro self-renewal ability and sustain tumor growth in vivo, generating human melanoma xenografts that recapitulate the phenotypic composition of the parental tumor. Melanomaspheres express high levels of Hedgehog (HH) pathway components and of embryonic pluripotent stem cell factors SOX2, NANOG, OCT4, and KLF4. We show that human melanomas contain a subset of cells expressing high ALDH activity (ALDH(high)), which is endowed with higher self-renewal and tumorigenic abilities than the ALDH(low) population. A good correlation between the number of ALDH(high) cells and sphere formation efficiency was observed. Notably, both pharmacological inhibition of HH signaling by the SMOOTHENED (SMO) antagonist cyclopamine and GLI antagonist GANT61 and stable expression of shRNA targeting either SMO or GLI1 result in a significant decrease in melanoma stem cell self-renewal in vitro and a reduction in the number of ALDH(high) melanoma stem cells. Finally, we show that interference with the HH-GLI pathway through lentiviral-mediated silencing of SMO and GLI1 drastically diminishes tumor initiation of ALDH(high) melanoma stem cells. In conclusion, our data indicate an essential role of the HH-GLI1 signaling in controlling self-renewal and tumor initiation of melanoma CSC/TIC. Targeting HH-GLI1 is thus predicted to reduce the melanoma stem cell compartment. Copyright © 2012 AlphaMed Press.

  14. Photocatalysis for Renewable Energy Production Using PhotoFuelCells

    Directory of Open Access Journals (Sweden)

    Robert Michal

    2014-11-01

    Full Text Available The present work is a short review of our recent studies on PhotoFuelCells, that is, photoelectrochemical cells which consume a fuel to produce electricity or hydrogen, and presents some unpublished data concerning both electricity and hydrogen production. PhotoFuelCells have been constructed using nanoparticulate titania photoanodes and various cathode electrodes bearing a few different types of electrocatalyst. In the case where the cell functioned with an aerated cathode, the cathode electrode was made of carbon cloth carrying a carbon paste made of carbon black and dispersed Pt nanoparticles. When the cell was operated in the absence of oxygen, the electrocatalyst was deposited on an FTO slide using a special commercial carbon paste, which was again enriched with Pt nanoparticles. Mixing of Pt with carbon paste decreased the quantity of Pt necessary to act as electrocatalyst. PhotoFuelCells can produce electricity without bias and with relatively high open-circuit voltage when they function in the presence of fuel and with an aerated cathode. In that case, titania can be sensitized in the visible region by CdS quantum dots. In the present work, CdS was deposited by the SILAR method. Other metal chalcogenides are not functional as sensitizers because the combined photoanode in their presence does not have enough oxidative power to oxidize the fuel. Concerning hydrogen production, it was found that it is difficult to produce hydrogen in an alkaline environment even under bias, however, this is still possible if losses are minimized. One way to limit losses is to short-circuit anode and cathode electrode and put them close together. This is achieved in the “photoelectrocatalytic leaf”, which was presently demonstrated capable of producing hydrogen even in a strongly alkaline environment.

  15. Protein Kinase-A Inhibition Is Sufficient to Support Human Neural Stem Cells Self-Renewal.

    Science.gov (United States)

    Georges, Pauline; Boissart, Claire; Poulet, Aurélie; Peschanski, Marc; Benchoua, Alexandra

    2015-12-01

    Human pluripotent stem cell-derived neural stem cells offer unprecedented opportunities for producing specific types of neurons for several biomedical applications. However, to achieve it, protocols of production and amplification of human neural stem cells need to be standardized, cost effective, and safe. This means that small molecules should progressively replace the use of media containing cocktails of protein-based growth factors. Here we have conducted a phenotypical screening to identify pathways involved in the regulation of hNSC self-renewal. We analyzed 80 small molecules acting as kinase inhibitors and identified compounds of the 5-isoquinolinesulfonamide family, described as protein kinase A (PKA) and protein kinase G inhibitors, as candidates to support hNSC self-renewal. Investigating the mode of action of these compounds, we found that modulation of PKA activity was central in controlling the choice between self-renewal or terminal neuronal differentiation of hNSC. We finally demonstrated that the pharmacological inhibition of PKA using the small molecule HA1004 was sufficient to support the full derivation, propagation, and long-term maintenance of stable hNSC in absence of any other extrinsic signals. Our results indicated that tuning of PKA activity is a core mechanism regulating hNSC self-renewal and differentiation and delineate the minimal culture media requirement to maintain undifferentiated hNSC in vitro. © 2015 AlphaMed Press.

  16. Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal.

    Science.gov (United States)

    Tian, Aiguo; Jiang, Jin

    2017-10-02

    Many adult organs including Drosophila adult midguts rely on resident stem cells to replenish damaged cells during tissue homeostasis and regeneration. Previous studies have shown that, upon injury, intestinal stem cells (ISCs) in the midguts can increase proliferation and lineage differentiation to meet the demand for tissue repair. Our recent study has demonstrated that, in response to certain injury, midguts can expand ISC population size as an additional regenerative mechanism. We found that injury elicited by bleomycin feeding or bacterial infection increased the production of two BMP ligands (Dpp and Gbb) in enterocytes (ECs), leading to elevated BMP signaling in progenitor cells that drove an expansion of ISCs by promoting their symmetric self-renewing division. Interestingly, we also found that BMP signaling in ECs inhibits the production of Dpp and Gbb, and that this negative feedback mechanism is required to reset ISC pool size to the homeostatic state. Our findings suggest that BMP signaling exerts two opposing influences on stem cell activity depending on where it acts: BMP signaling in progenitor cells promotes ISC self-renewal while BMP signaling in ECs restricts ISC self-renewal by preventing excessive production of BMP ligands. Our results further suggest that transient expansion of ISC population in conjunction with increasing ISC proliferation provides a more effective strategy for tissue regeneration.

  17. Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal.

    Science.gov (United States)

    Tang, Ling; Wang, Manman; Liu, Dahai; Gong, Mengting; Ying, Qi-Long; Ye, Shoudong

    2017-01-01

    Activation of signal transducer and activator of transcription 3 (STAT3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC) self-renewal. Our previous study showed that trans-acting transcription factor 5 (Sp5), an LIF/STAT3 downstream target, supports mESC self-renewal. However, the mechanism by which Sp5 exerts these effects remains elusive. Here, we found that Nanog is a direct target of Sp5 and mediates the self-renewal-promoting effect of Sp5 in mESCs. Overexpression of Sp5 induced Nanog expression, while knockdown or knockout of Sp5 decreased the Nanog level. Moreover, chromatin immunoprecipitation (ChIP) assays showed that Sp5 directly bound to the Nanog promoter. Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains. Taken together, our study provides unrecognized functions of Sp5 in mESCs and will expand our current understanding of the regulation of mESC pluripotency.

  18. SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

    Science.gov (United States)

    Rojas-Sutterlin, Shanti; Herblot, Sabine; Hébert, Josée; Sauvageau, Guy; Lemieux, Sébastien; Lécuyer, Eric; Veiga, Diogo F. T.; Hoang, Trang

    2014-01-01

    The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self-renewing cancer stem cells are poorly understood. Here, we exploit T-cell acute lymphoblastic leukemia (T-ALL) as a model to define the critical initiating events in this disease. First, thymocytes that are reprogrammed by the SCL and LMO1 oncogenic transcription factors into self-renewing pre-leukemic stem cells (pre-LSCs) remain non-malignant, as evidenced by their capacities to generate functional T cells. Second, we provide strong genetic evidence that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1. Moreover, LYL1 can substitute for SCL to reprogram thymocytes in concert with LMO1. In contrast, inhibition of E2A was not sufficient to substitute for SCL, indicating that thymocyte reprogramming requires transcription activation by SCL-LMO1. Third, only a specific subset of normal thymic cells, known as DN3 thymocytes, is susceptible to reprogramming. This is because physiological NOTCH1 signals are highest in DN3 cells compared to other thymocyte subsets. Consistent with this, overexpression of a ligand-independent hyperactive NOTCH1 allele in all immature thymocytes is sufficient to sensitize them to SCL-LMO1, thereby increasing the pool of self-renewing cells. Surprisingly, hyperactive NOTCH1 cannot reprogram thymocytes on its own, despite the fact that NOTCH1 is activated by gain of function mutations in more than 55% of T-ALL cases. Rather, elevating NOTCH1 triggers a parallel pathway involving Hes1 and Myc that dramatically enhances the activity of SCL-LMO1 We conclude that the acquisition of self-renewal and the genesis of pre-LSCs from thymocytes with a finite lifespan represent a critical first event in T-ALL. Finally, LYL1 and LMO1 or LMO2 are co-expressed in most human T-ALL samples, except the cortical T subtype. We therefore anticipate that the self-renewal network

  19. Lipopolysaccharide inhibits the self-renewal of spermatogonial stem cells in vitro via downregulation of GDNF expression in Sertoli cells.

    Science.gov (United States)

    Zhang, Xiaoli; Shi, Kun; Li, Yi; Zhang, Haiyu; Hao, Jing

    2014-06-01

    Lipopolysaccharide (LPS) can reduce sperm count and sperm quality. The molecular mechanisms underlying this process are not fully understood. In this report, we investigated the effects of LPS-treated Sertoli cells on self-renewal and differentiation of spermatogoinial stem cells (SSCs). Sertoli cell cultures were established and incubated with LPS (10μg/ml) for 1, 2 or 3 days, respectively. The culture media were collected and used as conditioned media (CM) to culture SSCs. The expression of glial cell-derived neurotrophic factor (GDNF), stem cell factor (SCF) and bone morphogenetic protein 4 (BMP4) in Sertoli cells treated with LPS was analyzed by RT-PCR and Western blotting. The results showed that the expression of SSC differentiation markers, c-kit and Sohlh2, was increased, while the expression of SSC self-renewal markers, plzf, oct4, and PCNA, was repressed when cultured in CM from LPS-treated Sertoli cells. GDNF levels in Sertoli cells and CM reduced dramatically after LPS treatments, while SCF and BMP4 levels did not show any significant changes. Moreover, correlated with the GDNF levels in CM, GDNF target genes, Bcl6b and Etv5, were reduced markedly in SSCs. Our results suggest that LPS inhibits the expression of GDNF in Sertoli cells, and might prevent the SSC self-renewal via down-regulation of GDNF target genes. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. The becoming organisation : a conversation about the added value of Chaordic Systems Thinking for organisational renewal

    NARCIS (Netherlands)

    Eijnatten, van F.M.; Wäfler, T.; Eijnatten, van F.M.

    2002-01-01

    This conceptual contribution explores the added value of Chaordic System Thinking (CST) for organisational renewal, and its consequences for future research. The paper starts with some essentials of CST (concepts of attractor, holon, discontinuous development, nonlinearity, chaordic properties). In

  1. Sizing Hydrogen Energy Storage in Consideration of Demand Response in Highly Renewable Generation Power Systems

    Directory of Open Access Journals (Sweden)

    Mubbashir Ali

    2018-05-01

    Full Text Available From an environment perspective, the increased penetration of wind and solar generation in power systems is remarkable. However, as the intermittent renewable generation briskly grows, electrical grids are experiencing significant discrepancies between supply and demand as a result of limited system flexibility. This paper investigates the optimal sizing and control of the hydrogen energy storage system for increased utilization of renewable generation. Using a Finnish case study, a mathematical model is presented to investigate the optimal storage capacity in a renewable power system. In addition, the impact of demand response for domestic storage space heating in terms of the optimal sizing of energy storage is discussed. Finally, sensitivity analyses are conducted to observe the impact of a small share of controllable baseload production as well as the oversizing of renewable generation in terms of required hydrogen storage size.

  2. Human Capacity Building in Energy Efficiency and Renewable Energy System Maintenance for the Yurok Tribe

    Energy Technology Data Exchange (ETDEWEB)

    Engel, R. A.' Zoellick, J J.

    2007-07-31

    From July 2005 to July 2007, the Schatz Energy Research Center (SERC) assisted the Yurok Tribe in the implementation of a program designed to build the Tribe’s own capacity to improve energy efficiency and maintain and repair renewable energy systems in Tribal homes on the Yurok Reservation. Funding for this effort was provided by the U.S. Department of Energy’s Tribal Program under First Steps grant award #DE-FG36-05GO15166. The program’s centerpiece was a house-by-house needs assessment, in which Tribal staff visited and conducted energy audits at over fifty homes. The visits included assessment of household energy efficiency and condition of existing renewable energy systems. Staff also provided energy education to residents, evaluated potential sites for new household renewable energy systems, and performed minor repairs as needed on renewable energy systems.

  3. 78 FR 79005 - Charter Renewal for the National Park System Advisory Board

    Science.gov (United States)

    2013-12-27

    ... amended. Certification: I hereby certify that the renewal of the National Park System Advisory Board is... of the Interior by the National Park Service Organic Act (16 U.S.C. 1 et seq.), and other statutes...

  4. Integrating High Levels of Variable Renewable Energy into Electric Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    Kroposki, Benjamin D. [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-08-01

    As more variable renewable energy is integrated into electric power systems, there are a range of challenges and solutions to accommodating very high penetration levels. This presentation highlights some of the recent research in this area.

  5. The Integration of Sustainable Transport into Future Renewable Energy Systems in China

    DEFF Research Database (Denmark)

    Liu, Wen

    use are largely lost in the current fossil fuel dominated energy systems. Sustainable transport development requires solutions from an overall renewable energy system in which integration of large-scale intermittent renewable energy needs assistance. Technologies of alternative vehicle fuels...... in transport may play a role in furthering such integration. The objective of this research is to make a contribution to the development of methodologies to identify and develop future sustainable transport systems as well as to apply such methodologies to the case of China. In particular, the methodological...... development focuses on 1) identifying suitable transport technologies and strategies based on renewable energy and 2) evaluating such technologies from the perspective of overall renewable energy system integration. For this purpose, a methodological framework involving the research fields of both...

  6. Leptin and Adiponectin Modulate the Self-renewal of Normal Human Breast Epithelial Stem Cells.

    Science.gov (United States)

    Esper, Raymond M; Dame, Michael; McClintock, Shannon; Holt, Peter R; Dannenberg, Andrew J; Wicha, Max S; Brenner, Dean E

    2015-12-01

    Multiple mechanisms are likely to account for the link between obesity and increased risk of postmenopausal breast cancer. Two adipokines, leptin and adiponectin, are of particular interest due to their opposing biologic functions and associations with breast cancer risk. In the current study, we investigated the effects of leptin and adiponectin on normal breast epithelial stem cells. Levels of leptin in human adipose explant-derived conditioned media positively correlated with the size of the normal breast stem cell pool. In contrast, an inverse relationship was found for adiponectin. Moreover, a strong linear relationship was observed between the leptin/adiponectin ratio in adipose conditioned media and breast stem cell self-renewal. Consistent with these findings, exogenous leptin stimulated whereas adiponectin suppressed breast stem cell self-renewal. In addition to local in-breast effects, circulating factors, including leptin and adiponectin, may contribute to the link between obesity and breast cancer. Increased levels of leptin and reduced amounts of adiponectin were found in serum from obese compared with age-matched lean postmenopausal women. Interestingly, serum from obese women increased stem cell self-renewal by 30% compared with only 7% for lean control serum. Taken together, these data suggest a plausible explanation for the obesity-driven increase in postmenopausal breast cancer risk. Leptin and adiponectin may function as both endocrine and paracrine/juxtacrine factors to modulate the size of the normal stem cell pool. Interventions that disrupt this axis and thereby normalize breast stem cell self-renewal could reduce the risk of breast cancer. ©2015 American Association for Cancer Research.

  7. Backup flexibility classes in emerging large-scale renewable electricity systems

    International Nuclear Information System (INIS)

    Schlachtberger, D.P.; Becker, S.; Schramm, S.; Greiner, M.

    2016-01-01

    Highlights: • Flexible backup demand in a European wind and solar based power system is modelled. • Three flexibility classes are defined based on production and consumption timescales. • Seasonal backup capacities are shown to be only used below 50% renewable penetration. • Large-scale transmission between countries can reduce fast flexible capacities. - Abstract: High shares of intermittent renewable power generation in a European electricity system will require flexible backup power generation on the dominant diurnal, synoptic, and seasonal weather timescales. The same three timescales are already covered by today’s dispatchable electricity generation facilities, which are able to follow the typical load variations on the intra-day, intra-week, and seasonal timescales. This work aims to quantify the changing demand for those three backup flexibility classes in emerging large-scale electricity systems, as they transform from low to high shares of variable renewable power generation. A weather-driven modelling is used, which aggregates eight years of wind and solar power generation data as well as load data over Germany and Europe, and splits the backup system required to cover the residual load into three flexibility classes distinguished by their respective maximum rates of change of power output. This modelling shows that the slowly flexible backup system is dominant at low renewable shares, but its optimized capacity decreases and drops close to zero once the average renewable power generation exceeds 50% of the mean load. The medium flexible backup capacities increase for modest renewable shares, peak at around a 40% renewable share, and then continuously decrease to almost zero once the average renewable power generation becomes larger than 100% of the mean load. The dispatch capacity of the highly flexible backup system becomes dominant for renewable shares beyond 50%, and reach their maximum around a 70% renewable share. For renewable shares

  8. Experimental study of mini SCADA renewable energy management system on microgrid using Raspberry Pi

    Science.gov (United States)

    Tridianto, E.; Permatasari, P. D.; Ali, I. R.

    2018-03-01

    Renewable Energy Management System (REMS) is a device that can be able to monitor power through a microgrid. The purpose of this system is to optimize power usage that produced from renewable energy with the result that reduces power demand from the grid. To reach the goal this device manage the load power needs fully supplied by renewable energy when the power produced from renewable energy is higher than load demand, besides power surplus will be stored in battery in this way energy stored in battery can be used when it needed. When the power produced from renewable energy can not satisfy the power demand, power will supply by renewable energy and grid. This device uses power meters for record any power flow through microgrid. In order to manage power flow in microgrid this system use relay module. The user can find out energy consumption (consumed by the load) and production (produced by renewable energy) in a period of time so that the user can switch on the load in right time.

  9. Definition of a remuneration system for heat from renewable resources; Ausgestaltung einer Einspeiseverguetung fuer erneuerbare Waerme

    Energy Technology Data Exchange (ETDEWEB)

    Dettli, R.; Ott, W.; Philippen, D.; Umbricht, A.

    2009-06-15

    This report for the Swiss Federal Office of Energy (SFOE) deals with proposals for a remuneration system for heat obtained from renewable resources. Local and regional district heating systems cover around three percent of Swiss heating needs. The authors estimate that, if these systems were to be operated completely using renewable resources such as biomass, ambient heat and the renewable portion of heat from waste incineration, around seven per cent of needs could be met. Further, around 10,000 heating systems with a power of more than 350 kW could be operated with renewables. A further potential for the use of renewable heating resources can be found in wastewater treatment plants and industrial waste heat. Various obstacles and restraints on the use of renewable resources in the heating area are discussed. The idea of providing a cost-covering remuneration system for heat is discussed and compared with that for renewable electricity. The proposed system is discussed, which would provide investment subsidies, risk-coverage and project development subsidies. The report discusses the results of a market analysis and the differences to be found between the markets for electricity and heat. Existing promotional programs are noted and the aims of a possible remuneration system are discussed. A concept for a promotion program for renewable heat generation and the use of waste heat is introduced. The installations to be promoted and the amount of remuneration to be paid out are discussed. Finally, the costs and the effects of the proposed promotion scheme are discussed. A comprehensive appendix provides details on the proposed system and provides information on market volume, energy resources, networks and infrastructure, providers of heat energy, heat consumers and general conditions as far as factors such as pricing and legislation are concerned. Finally, the 'Climate Cent' foundation is commented on.

  10. Stability Enhancement of a Power System Containing High-Penetration Intermittent Renewable Generation

    OpenAIRE

    Morel, Jorge; Obara, Shin’ya; Morizane, Yuta

    2015-01-01

    This paper considers the transient stability enhancement of a power system containing large amounts of solar and wind generation in Japan. Following the Fukushima Daiichi nuclear disaster there has been an increasing awareness on the importance of a distributed architecture, based mainly on renewable generation, for the Japanese power system. Also, the targets of CO2 emissions can now be approached without heavily depending on nuclear generation. Large amounts of renewable generation leads to...

  11. Power electronics for renewable energy systems, transportation and industrial applications

    CERN Document Server

    Malinowski, Mariusz; Al-Haddad, Kamal

    2014-01-01

    Power Electronics for Renewable Energy, Transportation, and Industrial Applications combines state-of-the-art global expertise to present the latest research on power electronics and its application in transportation, renewable energy, and different industrial applications. This timely book aims to facilitate the implementation of cutting-edge techniques to design problems offering innovative solutions to the growing power demands in small- and large-size industries. Application areas in the book range from smart homes and electric and plug-in hybrid electrical vehicles (PHEVs), to smart distribution and intelligence operation centers where significant energy efficiency improvements can be achieved through the appropriate use and design of power electronics and energy storage devices.

  12. Power electronics - key technology for renewable energy systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Iov, Florin; Kerekes, Tamas

    2011-01-01

    sources to renewable energy sources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss trends of the most emerging renewable energy sources, wind energy and photovoltaics, which by means of power electronics...... as efficient as possible. Further, the emerging climate changes is arguing to find sustainable future solutions. Of many options, two major technologies will play important roles to solve parts of those future problems. One is to change the electrical power production from conventional, fossil based energy......The electrical energy consumption continues to grow and more applications are based on electricity. We can expect that more 60% of all energy consumption will be converted and used as electricity. Therefore, it is a demand that production, distribution and use of electrical energy are done...

  13. Power Electronics and Control of Renewable Energy Systems

    DEFF Research Database (Denmark)

    Iov, Florin; Ciobotaru, Mihai; Sera, Dezso

    2007-01-01

    sources from the conventional, fossil (and short term) based energy sources to renewable energy resources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss some of the most emerging renewable energy sources......The global electrical energy consumption is still rising and there is a demand to double the power capacity within 20 years. The production, distribution and use of energy should be as technological efficient as possible and incentives to save energy at the end-user should also be set up....... Deregulation of energy has in the past lowered the investment in larger power plants, which means the need for new electrical power sources may be very high in the near future. Two major technologies will play important roles to solve the future problems. One is to change the electrical power production...

  14. Geographic Information Systems for the Regional Integration of Renewable Energies

    International Nuclear Information System (INIS)

    Amador Guerra, J.; Dominguez Bravo, J.

    2000-01-01

    This report is based on the project: The GIS in the regional integration of Renewable Energies for decentralised electricity production; developed by CIEMAT (Spanish Energy Research Centre) and UPM (Polytechnic University of Madrid, Spain) since 1997. The objective of this project is to analyse, evaluate and improve the GIS methodologies for application in RE and how GIS can aid in the evaluation and simulation of influence of technical, socio economical and geographical parameters. This project begin with the review of SOLARGIS methodology. SOLARGIS was developed by an european research team (included CIEMAT) in the frame of JOULE II Programme. In the first place this report described the state of the art in the application of GIS to Renewable Energies. In second place, the SOLARGIS review tasks and the application of this new product to Lorca (Murcia Region in Spain). Finally, the report describes the methodology for the spatial sensibility analysis. (Author) 24 refs

  15. Energy efficiency and renewable energy systems in Portugal and Brazil

    DEFF Research Database (Denmark)

    Østergaard, Poul Alberg; Soares, Isabel; Ferreira, Paula

    2014-01-01

    This article presents a review of the energy situation in Brazil and Portugal; two countries which are both characterised by high utilisation of renewable energy sources though with differences between them. The article also introduces contemporary energy research conducted on the two countries...... and presented at The 1st International Congress on Energy & Environment ranging from electricity end-use analyses, electricity production analyses to socio-economic assessment and large-scale energy scenarios....

  16. p38 MAPK pathway is essential for self-renewal of mouse male germline stem cells (mGSCs).

    Science.gov (United States)

    Niu, Zhiwei; Mu, Hailong; Zhu, Haijing; Wu, Jiang; Hua, Jinlian

    2017-02-01

    Male germline stem cells (mGSCs), also called spermatogonial stem cells (SSCs), constantly generate spermatozoa in male animals. A number of preliminary studies on mechanisms of mGSC self-renewal have previously been conducted, revealing that several factors are involved in this regulated process. The p38 MAPK pathway is widely conserved in multiple cell types in vivo, and plays an important role in cell proliferation, differentiation, inflammation and apoptosis. However, its role in self-renewal of mGSCs has not hitherto been determined. Here, the mouse mGSCs were cultured and their identity was verified by semi-RT-PCR, alkaline phosphatase (AP) staining and immunofluorescence staining. Then, the p38 MAPK pathway was blocked by p38 MAPK-specific inhibitor SB202190. mGSC self-renewal ability was then analysed by observation of morphology, cell number, cell growth analysis, TUNEL incorporation assay and cell cycle analysis. Results showed that mouse mGSC self-renewal ability was significantly inhibited by SB202190. This study showed for the first time that the p38 MAPK pathway plays a key role in maintaining self-renewal capacity of mouse mGSCs, which offers a new self-renewal pathway for these cells and contributes to overall knowledge of the mechanisms of mGSC self-renewal. © 2016 John Wiley & Sons Ltd.

  17. Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal

    Science.gov (United States)

    Lackford, Brad; Yao, Chengguo; Charles, Georgette M; Weng, Lingjie; Zheng, Xiaofeng; Choi, Eun-A; Xie, Xiaohui; Wan, Ji; Xing, Yi; Freudenberg, Johannes M; Yang, Pengyi; Jothi, Raja; Hu, Guang; Shi, Yongsheng

    2014-01-01

    mRNA alternative polyadenylation (APA) plays a critical role in post-transcriptional gene control and is highly regulated during development and disease. However, the regulatory mechanisms and functional consequences of APA remain poorly understood. Here, we show that an mRNA 3′ processing factor, Fip1, is essential for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Fip1 promotes stem cell maintenance, in part, by activating the ESC-specific APA profiles to ensure the optimal expression of a specific set of genes, including critical self-renewal factors. Fip1 expression and the Fip1-dependent APA program change during ESC differentiation and are restored to an ESC-like state during somatic reprogramming. Mechanistically, we provide evidence that the specificity of Fip1-mediated APA regulation depends on multiple factors, including Fip1-RNA interactions and the distance between APA sites. Together, our data highlight the role for post-transcriptional control in stem cell self-renewal, provide mechanistic insight on APA regulation in development, and establish an important function for APA in cell fate specification. PMID:24596251

  18. Matching renewable energy systems to village-level energy needs

    Energy Technology Data Exchange (ETDEWEB)

    Ashworth, J.H.; Neuendorffer, J.W.

    1980-06-01

    This report provides a five step process for matching alternative renewable energy technologies with energy needs in rural villages of developing countries. Analytic tools are given for each of the five steps as well as information that can be expected. Twelve characterization criteria are developed to assist in the matching process. Three of these criteria, called discrimination criteria, are used for preliminary screening of technology possibilities for each need. The other criteria address site-specific temporal, climatic, social, cultural, and environmental characteristics of the energy need, technology, and cost considerations. To illustrate the matching process, seven basic human needs for energy are matched with seven potential renewable energy technologies. The final portion of the paper discusses the advantages of such a matching process and the resources required to initiate such an effort within a development project. Specific recommendations are given for field-testing this process and actions that could be taken immediately in basic research and development, applied research and technology modification, demonstrations, and commercialization to assist in the future diffusion of renewable energy technologies to rural areas of developing countries.

  19. Sustainability index approach as a selection criteria for energy storage system of an intermittent renewable energy source

    International Nuclear Information System (INIS)

    Raza, Syed Shabbar; Janajreh, Isam; Ghenai, Chaouki

    2014-01-01

    Highlights: • Three renewable energy storage options considered: lead acid and lithium polymer batteries and fuel cell. • Hydrogen fuel cell system is the most feasible energy storage option for the long term energy storage. • Sustainability index approach is a novel method used to quantify the qualitative properties of the system. - Abstract: The sustainability index is an adaptive, multicriteria and novel technique that is used to compare different energy storage systems for their sustainability. This innovative concept utilizes both qualitative and quantitative results to measure sustainability through an index based approach. This report aims to compare three different energy storage options for an intermittent renewable energy source. The three energy storage options are lead acid batteries, lithium polymer batteries and fuel cell systems, that are selected due to their availability and the geographical constrain of using other energy storage options. The renewable energy source used is solar photovoltaic (PV). Several technical, economic and environmental factors have been discussed elaborately which would help us to evaluate the merits of the energy storage system for long term storage. Finally, a novel sustainability index has been proposed which quantifies the qualitative and quantitative aspects of the factors discussed, and thus helps us choose the ideal energy storage system for our scenario. A weighted sum approach is used to quantify each factor according to their importance. After a detailed analysis of the three energy storage systems through the sustainability index approach, the most feasible energy storage option was found to be fuel cell systems which can provide a long term energy storage option and also environmental friendly

  20. Optimal Sizing of Hybrid Renewable Energy Systems: An Application for Real Demand in Qatar Remote Area

    Science.gov (United States)

    Alyafei, Nora

    Renewable energy (RE) sources are becoming popular for power generations due to advances in renewable energy technologies and their ability to reduce the problem of global warming. However, their supply varies in availability (as sun and wind) and the required load demand fluctuates. Thus, to overcome the uncertainty issues of RE power sources, they can be combined with storage devices and conventional energy sources in a Hybrid Power Systems (HPS) to satisfy the demand load at any time. Recently, RE systems received high interest to take advantage of their positive benefits such as renewable availability and CO2 emissions reductions. The optimal design of a hybrid renewable energy system is mostly defined by economic criteria, but there are also technical and environmental criteria to be considered to improve decision making. In this study three main renewable sources of the system: photovoltaic arrays (PV), wind turbine generators (WG) and waste boilers (WB) are integrated with diesel generators and batteries to design a hybrid system that supplies the required demand of a remote area in Qatar using heuristic approach. The method utilizes typical year data to calculate hourly output power of PV, WG and WB throughout the year. Then, different combinations of renewable energy sources with battery storage are proposed to match hourly demand during the year. The design which satisfies the desired level of loss of power supply, CO 2 emissions and minimum costs is considered as best design.

  1. Power situation in German and lessons for Japan. Expanding renewable energy and fluctuating FIT system

    International Nuclear Information System (INIS)

    Kitamura, Kazuya

    2016-01-01

    In Germany, energy shift has now caused that a quarter of the total consumed power is obtained from renewable energy sources. There, a shift from nuclear energy has been achieved, and the dissemination of renewable energy as industrial creation has been demanded. However, the Renewable Energy Act, which was the promoter of the above process, was revised drastically in August 2014. Although evaluation on the revised Renewable Energy Act is a future work, it is said that this revision is quite severe for the parties who have promoted the renewable energy business in local regions and enjoyed the profiles locally. Regarding electricity, the German government has a strong industrial protection policy. This paper summarized the basic stance of the German government, by taking up the specific examples of actual electricity fee and the reduction/exemption system of levies on power consumption type companies. The German government clearly shows its willingness to adhere to be an industrial nation. In Germany, the wholesaling spot price of electricity declined due to the spread of renewable energy. This also comes from the mechanism of the FIT system. Unlike Germany where FIT system started in 2000, levies are still small affecting less in Japan where the FIT system has just begun. However, in Germany, it is a big problem. In order to discuss the ideal way of FIT system in Japan, it is necessary to know as accurately as possible what the reality is, including about overseas precedents. (A.O.)

  2. Research and deployment priorities for renewable technologies: Quantifying the importance of various renewable technologies for low cost, high renewable electricity systems in an Australian case study

    International Nuclear Information System (INIS)

    Riesz, Jenny; Elliston, Ben

    2016-01-01

    This study aims to identify research priorities to enable low cost, high renewable power systems. An evolutionary program optimises the mix of technologies in 100% renewable energy portfolios (RE) in the Australian National Electricity Market. Various technologies are reduced in availability to determine their relative importance for achieving low costs. The single most important factor is found to be the integration of large quantities of wind; therefore wind integration is identified as a research priority. In contrast, photovoltaics are found to “saturate” the system at less than 10% of total energy (in the absence of storage or demand management, installation of further photovoltaics does not contribute significant further value). This indicates that policies to promote utility-scale photovoltaics should be considered in partnership with complementary measures (such as demand side participation and storage). Biofuelled gas turbines are found to be important; a complete absence of bioenergy increases costs by AU$20–30/MWh, and even having only 0.1 TWh per year of bioenergy available reduces average costs by AU$3–4/MWh. Limits on the non-synchronous penetration (NSP) are found to be relatively expensive, suggesting a significant research priority around finding alternative approaches to providing synchronous services, such as inertia. Geothermal and concentrating solar thermal technologies do not appear essential as long as sufficient wind and peaking bioenergy is available. - Highlights: • Photovoltaics saturate early, suggesting they need complementary measures. • Biofuelled gas turbines or another peaking technology are important for low costs. • Limits on the non-synchronous penetration are relatively expensive.

  3. Review of FACTS technologies and applications for power quality in smart grids with renewable energy systems

    DEFF Research Database (Denmark)

    Gandoman, Foad H.; Ahmadi, Abdollah; Sharaf, Adel M.

    2018-01-01

    In the last two decades, emerging use of renewable and distributed energy sources in electricity grid has created new challenges for the utility regarding the power quality, voltage stabilization and efficient energy utilization. Power electronic converters are extensively utilized to interface...... the power quality. Also, distributed FACTSs play an important role in improving the power factor, energy utilization, enhancing the power quality, and ensuring efficient energy utilization and energy management in smart grids with renewable energy sources. This paper presents a literature survey of FACTS...... technology tools and applications for power quality and efficient renewable energy system utilization....

  4. The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

    DEFF Research Database (Denmark)

    Stewart, Morag H; Albert, Mareike; Sroczynska, Patrycja

    2015-01-01

    Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer, however its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias...... compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential.......Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer, however its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias....... Constitutive genetic deletion of Jarid1b did not impact steady-state hematopoiesis. In contrast, acute deletion of Jarid1b from bone marrow increased peripheral blood T cells and, following secondary transplantation, resulted in loss of bone marrow reconstitution. Our results reveal that deletion of Jarid1b...

  5. LIRA - License Renewal Assistant an expert system advisor for system and component screening

    International Nuclear Information System (INIS)

    Wood, R.M.; DeLuke, R.J.; Lu, Yi; Catron, S.R.

    1992-01-01

    In developing a license renewal application for a nuclear power plant, it is necessary to identify those systems and components for which age-related degradation must be evaluated and addressed in detail. One approach, used in the Monticello Lead Plant project, is to screen all plant systems and components, based on criteria developed by the Nuclear Utility Management and Resources Council (NUMARC). This paper describes an expert system developed as an assistant in the application of the screening methodology. 4 refs., 5 figs., 1 tab

  6. Design for micro-combined cooling, heating and power systems stirling engines and renewable power systems

    CERN Document Server

    2015-01-01

    ‘Design for Micro-Combined Cooling, Heating & Power Systems’ provides a manual for the technical and structural design of systems for supplying decentralised energy in residential buildings. It presents the micro-combined cooling, heating & power systems Stirling engines & renewable energy sources (mCCHP-SE-RES) systems in an accessible manner both for the public at large, and for professionals who conceive, design or commercialise such systems or their components.  The high performance levels of these systems are demonstrated within the final chapter by the results of an experiment in which a house is equipped with a mCCHP-SE-RES system. The reader is also familiarized with the conceptual, technical and legal aspects of modern domestic energy systems; the components that constitute these systems; and advanced algorithms for achieving the structural and technical design of such systems. In residential buildings, satisfying demands of durable development has gradually evolved from necessity to...

  7. Large Scale Integration of Renewable Power Sources into the Vietnamese Power System

    Science.gov (United States)

    Kies, Alexander; Schyska, Bruno; Thanh Viet, Dinh; von Bremen, Lueder; Heinemann, Detlev; Schramm, Stefan

    2017-04-01

    The Vietnamese Power system is expected to expand considerably in upcoming decades. Power capacities installed are projected to grow from 39 GW in 2015 to 129.5 GW by 2030. Installed wind power capacities are expected to grow to 6 GW (0.8 GW 2015) and solar power capacities to 12 GW (0.85 GW 2015). This goes hand in hand with an increase of the renewable penetration in the power mix from 1.3% from wind and photovoltaics (PV) in 2015 to 5.4% by 2030. The overall potential for wind power in Vietnam is estimated to be around 24 GW. Moreover, the up-scaling of renewable energy sources was formulated as one of the priorized targets of the Vietnamese government in the National Power Development Plan VII. In this work, we investigate the transition of the Vietnamese power system towards high shares of renewables. For this purpose, we jointly optimise the expansion of renewable generation facilities for wind and PV, and the transmission grid within renewable build-up pathways until 2030 and beyond. To simulate the Vietnamese power system and its generation from renewable sources, we use highly spatially and temporally resolved historical weather and load data and the open source modelling toolbox Python for Power System Analysis (PyPSA). We show that the highest potential of renewable generation for wind and PV is observed in southern Vietnam and discuss the resulting need for transmission grid extensions in dependency of the optimal pathway. Furthermore, we show that the smoothing effect of wind power has several considerable beneficial effects and that the Vietnamese hydro power potential can be efficiently used to provide balancing opportunities. This work is part of the R&D Project "Analysis of the Large Scale Integration of Renewable Power into the Future Vietnamese Power System" (GIZ, 2016-2018).

  8. Effects of the Endocrine-Disrupting Chemical DDT on Self-Renewal and Differentiation of Human Mesenchymal Stem Cells

    Science.gov (United States)

    Strong, Amy L.; Shi, Zhenzhen; Strong, Michael J.; Miller, David F.B.; Rusch, Douglas B.; Buechlein, Aaron M.; Flemington, Erik K.; McLachlan, John A.; Nephew, Kenneth P.

    2014-01-01

    Background: Although the global use of the endocrine-disrupting chemical DDT has decreased, its persistence in the environment has resulted in continued human exposure. Accumulating evidence suggests that DDT exposure has long-term adverse effects on development, yet the impact on growth and differentiation of adult stem cells remains unclear. Objectives: Human mesenchymal stem cells (MSCs) exposed to DDT were used to evaluate the impact on stem cell biology. Methods: We assessed DDT-treated MSCs for self-renewal, proliferation, and differentiation potential. Whole genome RNA sequencing was performed to assess gene expression in DDT-treated MSCs. Results: MSCs exposed to DDT formed fewer colonies, suggesting a reduction in self-renewal potential. DDT enhanced both adipogenic and osteogenic differentiation, which was confirmed by increased mRNA expression of glucose transporter type 4 (GLUT4), lipoprotein lipase (LpL), peroxisome proliferator-activated receptor gamma (PPARγ), leptin, osteonectin, core binding factor 1 (CBFA1), and FBJ murine osteosarcoma viral oncogene homolog (c-Fos). Expression of factors in DDT-treated cells was similar to that in estrogen-treated MSCs, suggesting that DDT may function via the estrogen receptor (ER)-mediated pathway. The coadministration of ICI 182,780 blocked the effects of DDT. RNA sequencing revealed 121 genes and noncoding RNAs to be differentially expressed in DDT-treated MSCs compared with controls cells. Conclusion: Human MSCs provide a powerful biological system to investigate and identify the molecular mechanisms underlying the effects of environmental agents on stem cells and human health. MSCs exposed to DDT demonstrated profound alterations in self-renewal, proliferation, differentiation, and gene expression, which may partially explain the homeostatic imbalance and increased cancer incidence among those exposed to long-term EDCs. Citation: Strong AL, Shi Z, Strong MJ, Miller DF, Rusch DB, Buechlein AM, Flemington EK

  9. An examination of isolated, stationary, hydrogen power systems supplied by renewables: component and system issues and criteria necessary for successful worldwide deployment

    Energy Technology Data Exchange (ETDEWEB)

    Rambach, G. D. [Energy and Environmental Engineering Center, Desert Research Institute, Reno, NV (United States)

    1999-12-01

    The premise of this paper is that remote, stationary power systems, based on indigenous renewable energy sources, are an ideal market entry opportunity for hydrogen, but that the deployment of isolated power systems relying on hydrogen as the energy storage medium requires complex and comprehensive planning and design considerations to provide for successful market entry strategies and appropriate systems engineering. Accordingly, this paper sets out to discuss the criteria and the framework necessary to determine how to successfully deploy any specific system or to plan a global marketing strategy. Details of the indigenous intermittent energy sources (wind turbines, solar photovoltaic, micro-hydroelectric, etc), primary power-to-hydrogen conversion systems, hydrogen storage methods, and hydrogen-to-electricity conversion systems (hydrogen-internal combustion engine generator set, hydrogen fuel cells) are described, along with the criteria for technically and commercially successful deployment of any renewable utility power system that employs energy storage.2 refs., 4 figs.

  10. Protein kinase C regulates human pluripotent stem cell self-renewal.

    Directory of Open Access Journals (Sweden)

    Masaki Kinehara

    Full Text Available The self-renewal of human pluripotent stem (hPS cells including embryonic stem and induced pluripotent stem cells have been reported to be supported by various signal pathways. Among them, fibroblast growth factor-2 (FGF-2 appears indispensable to maintain self-renewal of hPS cells. However, downstream signaling of FGF-2 has not yet been clearly understood in hPS cells.In this study, we screened a kinase inhibitor library using a high-throughput alkaline phosphatase (ALP activity-based assay in a minimal growth factor-defined medium to understand FGF-2-related molecular mechanisms regulating self-renewal of hPS cells. We found that in the presence of FGF-2, an inhibitor of protein kinase C (PKC, GF109203X (GFX, increased ALP activity. GFX inhibited FGF-2-induced phosphorylation of glycogen synthase kinase-3β (GSK-3β, suggesting that FGF-2 induced PKC and then PKC inhibited the activity of GSK-3β. Addition of activin A increased phosphorylation of GSK-3β and extracellular signal-regulated kinase-1/2 (ERK-1/2 synergistically with FGF-2 whereas activin A alone did not. GFX negated differentiation of hPS cells induced by the PKC activator, phorbol 12-myristate 13-acetate whereas Gö6976, a selective inhibitor of PKCα, β, and γ isoforms could not counteract the effect of PMA. Intriguingly, functional gene analysis by RNA interference revealed that the phosphorylation of GSK-3β was reduced by siRNA of PKCδ, PKCε, and ζ, the phosphorylation of ERK-1/2 was reduced by siRNA of PKCε and ζ, and the phosphorylation of AKT was reduced by PKCε in hPS cells.Our study suggested complicated cross-talk in hPS cells that FGF-2 induced the phosphorylation of phosphatidylinositol-3 kinase (PI3K/AKT, mitogen-activated protein kinase/ERK-1/2 kinase (MEK, PKC/ERK-1/2 kinase, and PKC/GSK-3β. Addition of GFX with a MEK inhibitor, U0126, in the presence of FGF-2 and activin A provided a long-term stable undifferentiated state of hPS cells even though h

  11. Protein Kinase C Regulates Human Pluripotent Stem Cell Self-Renewal

    Science.gov (United States)

    Kinehara, Masaki; Kawamura, Suguru; Tateyama, Daiki; Suga, Mika; Matsumura, Hiroko; Mimura, Sumiyo; Hirayama, Noriko; Hirata, Mitsuhi; Uchio-Yamada, Kozue; Kohara, Arihiro; Yanagihara, Kana; Furue, Miho K.

    2013-01-01

    Background The self-renewal of human pluripotent stem (hPS) cells including embryonic stem and induced pluripotent stem cells have been reported to be supported by various signal pathways. Among them, fibroblast growth factor-2 (FGF-2) appears indispensable to maintain self-renewal of hPS cells. However, downstream signaling of FGF-2 has not yet been clearly understood in hPS cells. Methodology/Principal Findings In this study, we screened a kinase inhibitor library using a high-throughput alkaline phosphatase (ALP) activity-based assay in a minimal growth factor-defined medium to understand FGF-2-related molecular mechanisms regulating self-renewal of hPS cells. We found that in the presence of FGF-2, an inhibitor of protein kinase C (PKC), GF109203X (GFX), increased ALP activity. GFX inhibited FGF-2-induced phosphorylation of glycogen synthase kinase-3β (GSK-3β), suggesting that FGF-2 induced PKC and then PKC inhibited the activity of GSK-3β. Addition of activin A increased phosphorylation of GSK-3β and extracellular signal-regulated kinase-1/2 (ERK-1/2) synergistically with FGF-2 whereas activin A alone did not. GFX negated differentiation of hPS cells induced by the PKC activator, phorbol 12-myristate 13-acetate whereas Gö6976, a selective inhibitor of PKCα, β, and γ isoforms could not counteract the effect of PMA. Intriguingly, functional gene analysis by RNA interference revealed that the phosphorylation of GSK-3β was reduced by siRNA of PKCδ, PKCε, and ζ, the phosphorylation of ERK-1/2 was reduced by siRNA of PKCε and ζ, and the phosphorylation of AKT was reduced by PKCε in hPS cells. Conclusions/Significance Our study suggested complicated cross-talk in hPS cells that FGF-2 induced the phosphorylation of phosphatidylinositol-3 kinase (PI3K)/AKT, mitogen-activated protein kinase/ERK-1/2 kinase (MEK), PKC/ERK-1/2 kinase, and PKC/GSK-3β. Addition of GFX with a MEK inhibitor, U0126, in the presence of FGF-2 and activin A provided a long

  12. Energy system analysis of 100% renewable energy systems-The case of Denmark in years 2030 and 2050

    DEFF Research Database (Denmark)

    Lund, Henrik; Mathiesen, Brian Vad

    2009-01-01

    for two energy target years: year 2050 with 100% renewable energy from biomass and combinations of wind, wave and solar power; and year 2030 with 50% renewable energy, emphasising the first important steps on the way. The conclusion is that a 100% renewable energy supply based on domestic resources......This paper presents the methodology and results of the overall energy system analysis of a 100% renewable energy system. The input for the systems is the result of a project of the Danish Association of Engineers, in which 1600 participants during more than 40 seminars discussed and designed...... a model for the future energy system of Denmark. The energy system analysis methodology includes hour by hour computer simulations leading to the design of flexible energy systems with the ability to balance the electricity supply and demand. The results are detailed system designs and energy balances...

  13. Impacts of Renewable Energy Quota System on China's Future Power Sector

    DEFF Research Database (Denmark)

    Xiong, Weiming; Zhang, Da; Mischke, Peggy

    2014-01-01

    As the biggest carbon emitting sector which produces 44% of current national carbon emission in China, the coal-dominated power sector has a tremendous potential for CO2 mitigation in the next two decades. Renewable energy quota system is currently discussed as a potential future policy instrument...... for the power sector, which requires certain fraction of renewable energy in total power generation for each province and grid zone. The quantitative studies on renewable energy quota for China are still very limited. Based on a least-cost and technology-rich power generation and transmission expansion model...... for China, this study examines the impacts of renewable energy quota system and carbon cap policy instruments on the future Chinese power sector. Various scenarios are examined toward 2030 and their future power generation mix, capacity installations and carbon emission are discussed. This study concludes...

  14. Financial incentives to promote renewable energy systems in European electricity markets: a survey

    International Nuclear Information System (INIS)

    Haas, R.; Huber, C.; Wohlgemuth, N.

    2001-01-01

    Renewable energy systems may contribute to sustainable development. Therefore, one of the challenges for energy policy is to ensure that renewable energy options have a fair opportunity to compete with other supply resources. This paper presents a survey on promotion mechanisms to enhance the market penetration of renewable energies in European electricity markets. Strategies include rebates and tax incentives, regulated rates, system benefit charges, bidding-oriented mechanisms and various types of green pricing programs. The paper concludes that efficient promotion mechanisms should focus on incentives per kWh generated rather than on rebates on the investment in generating capacity (kW), and that there is no one single program type which has the best application to the promotion of all renewable technologies. For example, enhanced buy-back rates work as a dissemination strategy for wind energy but they do not work for photovoltaics. (author)

  15. Smart Energy Systems for coherent 100% renewable energy and transport solutions

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Connolly, David

    2015-01-01

    The hypothesis of this paper is that in order to identify least cost solutions of the integration of fluctuating renewable energy sources into current or future 100% renewable energy supplies one has to take a Smart Energy Systems approach. This paper outline why and how to do so. Traditionally......, significant focus is put on the electricity sector alone to solve the renewable energy integration puzzle. Smart grid research traditionally focuses on ICT, smart meters, electricity storage technologies, and local (electric) smart grids. In contrast, the Smart Energy System focuses on merging the electricity......, heating and transport sectors, in combination with various intra-hour, hourly, daily, seasonal and biannual storage options, to create the flexibility necessary to integrate large penetrations of fluctuating renewable energy. However, in this paper we present the development and design of coherent Smart...

  16. Renewable energy resources for distributed generation systems in South Africa

    Energy Technology Data Exchange (ETDEWEB)

    Szewczuk, Stefan

    2010-09-15

    The South African Government has objective to provide universal access of electricity for its citizens and its electrification programme has been successful but focus has moved from numbers of connections to one of achieving sustainable socio-economic benefits. First-hand understanding was obtained of the complexity of socio-economic development where CSIR undertook a project in the rural areas of South Africa to identify electrification opportunities using renewable energy linked to economic activities. Lessons formed basis of a government funding implementation of pilot hybrid mini-grids to inform a future rollout. Results informed the development of distributed generation concepts and an integrated methodology.

  17. Stochastic Modeling and Analysis of Power System with Renewable Generation

    DEFF Research Database (Denmark)

    Chen, Peiyuan

    Unlike traditional fossil-fuel based power generation, renewable generation such as wind power relies on uncontrollable prime sources such as wind speed. Wind speed varies stochastically, which to a large extent determines the stochastic behavior of power generation from wind farms...... that such a stochastic model can be used to simulate the effect of load management on the load duration curve. As CHP units are turned on and off by regulating power, CHP generation has discrete output and thus can be modeled by a transition matrix based discrete Markov chain. As the CHP generation has a strong diurnal...

  18. Self-renewal and chemotherapy resistance of p75NTR positive cells in esophageal squamous cell carcinomas

    International Nuclear Information System (INIS)

    Huang, Sheng-Dong; Yuan, Yang; Liu, Xiao-Hong; Gong, De-Jun; Bai, Chen-Guang; Wang, Feng; Luo, Jun-Hui; Xu, Zhi-Yun

    2009-01-01

    p75 NTR has been used to isolate esophageal and corneal epithelial stem cells. In the present study, we investigated the expression of p75 NTR in esophageal squamous cell carcinoma (ESCC) and explored the biological properties of p75 NTR+ cells. p75 NTR expression in ESCC was assessed by immunohistochemistry. p75 NTR+ and p75 NTR- cells of 4 ESCC cell lines were separated by fluorescence-activated cell sorting. Differentially expressed genes between p75 NTR+ and p75 NTR- cells were determined by real-time quantitative reverse transcription-PCR. Sphere formation assay, DDP sensitivity assay, 64 copper accumulation assay and tumorigenicity analysis were performed to determine the capacity of self-renewal, chemotherapy resistance and tumorigenicity of p75 NTR+ cells. In ESCC specimens, p75 NTR was found mainly confined to immature cells and absent in cells undergoing terminal differentiation. The percentage of p75 NTR+ cells was 1.6%–3.7% in Eca109 and 3 newly established ESCC cell lines. The expression of Bmi-1, which is associated with self-renewal of stem cells, was significantly higher in p75 NTR+ cells. p63, a marker identified in keratinocyte stem cells, was confined mainly to p75 NTR+ cells. The expression of CTR1, which is associated with cisplatin (DDP)-resistance, was significantly decreased in p75 NTR+ cells. Expression levels of differentiation markers, such as involucrin, cytokeratin 13, β1-integrin and β4-integrin, were lower in p75 NTR+ cells. In addition, p75 NTR+ cells generated both p75 NTR+ and p75 NTR- cells, and formed nonadherent spherical clusters in serum-free medium supplemented with growth factors. Furthermore, p75 NTR+ cells were found to be more resistant to DDP and exhibited lower 64 copper accumulation than p75 NTR- cells. Our results demonstrated that p75 NTR+ cells possess some characteristics of CSCs, namely, self-renewal and chemotherapy resistance. Chemotherapy resistance of p75 NTR+ cells may probably be attributable to

  19. Development and Testing of Protection Scheme for Renewable-Rich Distribution System

    Energy Technology Data Exchange (ETDEWEB)

    Brahma, Sukumar [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ranade, Satish [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Elkhatib, Mohamed E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ellis, Abraham [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Reno, Matthew J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-09-01

    As the penetration of renewables increases in the distribution systems, and microgrids are conceived with high penetration of such generation that connects through inverters, fault location and protection of microgrids needs consideration. This report proposes averaged models that help simulate fault scenarios in renewable-rich microgrids, models for locating faults in such microgrids, and comments on the protection models that may be considered for microgrids. Simulation studies are reported to justify the models.

  20. RE-Europe, a large-scale dataset for modeling a highly renewable European electricity system

    DEFF Research Database (Denmark)

    Jensen, Tue Vissing; Pinson, Pierre

    2017-01-01

    , we describe a dedicated large-scale dataset for a renewable electric power system. The dataset combines a transmission network model, as well as information for generation and demand. Generation includes conventional generators with their technical and economic characteristics, as well as weather-driven...... to the evaluation, scaling analysis and replicability check of a wealth of proposals in, e.g., market design, network actor coordination and forecastingof renewable power generation....

  1. Organizational precedents for ownership and management of decentralized renewable-energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Meunier, R.; Silversmith, J.A.

    1981-03-01

    Three existing organizational types that meet the decentralization criteria of local consumer ownership and control - cooperatives, Rural Electric Cooperatives, and municipal utilities - are examined. These three organizational precedents are analyzed in terms of their histories, structures, legal powers, sources of capital, and social and political aspects. Examples of related experiments with renewable energy technologies are given, and inferences are drawn regarding the organizations' suitability as vehicles for future implementation of decentralized renewable energy systems.

  2. Electrochemical Systems for Renewable Energy Conversion from Salinity and Proton Gradients

    OpenAIRE

    Morais, William G.; Lima, Gilberto; Gomes, Wellington J. A. S.; Huguenin, Fritz

    2018-01-01

    Ever-rising energy demand, fossil fuel dependence, and climate issues have harmful consequences to the society. Exploring clean and renewable energy to diversify the world energy matrix has become an urgent matter. Less explored or unexplored renewable energy sources like the salinity and proton gradient energy are an attractive alternative with great energy potential. This paper discusses important electrochemical systems for energy conversion from natural and artificial concentration gradie...

  3. Hydrogen and renewable energy sources integrated system for greenhouse heating

    Directory of Open Access Journals (Sweden)

    Ileana Blanco

    2013-09-01

    Full Text Available A research is under development at the Department of Agro- Environmental Sciences of the University of Bari “Aldo Moro” in order to investigate the suitable solutions of a power system based on solar energy (photovoltaic and hydrogen, integrated with a geothermal heat pump for powering a self sustained heated greenhouse. The electrical energy for heat pump operation is provided by a purpose-built array of solar photovoltaic modules, which supplies also a water electrolyser system controlled by embedded pc; the generated dry hydrogen gas is conserved in suitable pressured storage tank. The hydrogen is used to produce electricity in a fuel cell in order to meet the above mentioned heat pump power demand when the photovoltaic system is inactive during winter night-time or the solar radiation level is insufficient to meet the electrical demand. The present work reports some theoretical and observed data about the electrolyzer operation. Indeed the electrolyzer has required particular attention because during the experimental tests it did not show a stable operation and it was registered a performance not properly consistent with the predicted performance by means of the theoretical study.

  4. Power system and market integration of renewable electricity

    Science.gov (United States)

    Erdmann, Georg

    2017-07-01

    This paper addresses problems of power generation markets that arise under high shares of intermittent generation. After discussing the economic fundamentals of wind and photovoltaic investments, the paper introduces the concept of the "Merit order effect of renewables". According to this concept electricity prices on wholesale power markets become smaller in periods during which large volumes of wind and photovoltaic generation is available and squeeze out relative expensive gas-fired power generation. The merit order effect of renewables has a couple of consequences. Among others it challenges the profitability of conventional power generation. If such generation capacities are still necessary, at least during a transitory period, a capacity mechanism may be put in place that generates an additional stream of income to the operators of conventional power generators. Another consequence of growing intermittent power generation is the need for concepts and technologies that deal with excess generation. Among these concepts are virtual and physical power storage capacities. In the last parts of the paper models are presented that are able to analyze these concepts from an economic point of view.

  5. Efficient thermal desalination technologies with renewable energy systems: A state-of-the-art review

    International Nuclear Information System (INIS)

    Esfahani, Iman Janghorban; Rashidi, Jouan; Ifaei, Pouya; Yoo, ChangKyoo

    2016-01-01

    Due to the current fossil fuel crisis and associated adverse environmental impacts, renewable energy sources (RES) have drawn interest as alternatives to fossil fuels for powering water desalination systems. Over the last few decades the utility of renewable energy sources such as solar, geothermal, and wind to run desalination processes has been explored. However, the expansion of these technologies to larger scales is hampered by techno-economic and thermo-economic challenges. This paper reviews the state-of-the-art in the field of renewable energy-powered thermal desalination systems (RE-PTD) to compare their productivity and efficiency through thermodynamic, economic, and environmental analyses. We performed a comparative study using published data to classify RE-PTD systems technologies on the basis of the energy collection systems that they use. Among RE-PTD systems, solar energy powered-thermal desalination systems demonstrate high thermo-environ-economic efficiency to produce fresh water to meet various scales of demand.

  6. Efficient thermal desalination technologies with renewable energy systems: A state-of-the-art review

    Energy Technology Data Exchange (ETDEWEB)

    Esfahani, Iman Janghorban; Rashidi, Jouan; Ifaei, Pouya; Yoo, ChangKyoo [Center for Environmental Studies, Kyung Hee University, Yongin (Korea, Republic of)

    2016-02-15

    Due to the current fossil fuel crisis and associated adverse environmental impacts, renewable energy sources (RES) have drawn interest as alternatives to fossil fuels for powering water desalination systems. Over the last few decades the utility of renewable energy sources such as solar, geothermal, and wind to run desalination processes has been explored. However, the expansion of these technologies to larger scales is hampered by techno-economic and thermo-economic challenges. This paper reviews the state-of-the-art in the field of renewable energy-powered thermal desalination systems (RE-PTD) to compare their productivity and efficiency through thermodynamic, economic, and environmental analyses. We performed a comparative study using published data to classify RE-PTD systems technologies on the basis of the energy collection systems that they use. Among RE-PTD systems, solar energy powered-thermal desalination systems demonstrate high thermo-environ-economic efficiency to produce fresh water to meet various scales of demand.

  7. Stability Enhancement of a Power System Containing High-Penetration Intermittent Renewable Generation

    Directory of Open Access Journals (Sweden)

    Jorge Morel

    2015-06-01

    Full Text Available This paper considers the transient stability enhancement of a power system containing large amounts of solar and wind generation in Japan. Following the Fukushima Daiichi nuclear disaster there has been an increasing awareness on the importance of a distributed architecture, based mainly on renewable generation, for the Japanese power system. Also, the targets of CO2 emissions can now be approached without heavily depending on nuclear generation. Large amounts of renewable generation leads to a reduction in the total inertia of the system because renewable generators are connected to the grid by power converters, and transient stability becomes a significant issue. Simulation results show that sodium-sulfur batteries can keep the system in operation and stable after strong transient disturbances, especially for an isolated system. The results also show how the reduction of the inertia in the system can be mitigated by exploiting the kinetic energy of wind turbines.

  8. On-Site Renewable Energy and Green Buildings: A System-Level Analysis.

    Science.gov (United States)

    Al-Ghamdi, Sami G; Bilec, Melissa M

    2016-05-03

    Adopting a green building rating system (GBRSs) that strongly considers use of renewable energy can have important environmental consequences, particularly in developing countries. In this paper, we studied on-site renewable energy and GBRSs at the system level to explore potential benefits and challenges. While we have focused on GBRSs, the findings can offer additional insight for renewable incentives across sectors. An energy model was built for 25 sites to compute the potential solar and wind power production on-site and available within the building footprint and regional climate. A life-cycle approach and cost analysis were then completed to analyze the environmental and economic impacts. Environmental impacts of renewable energy varied dramatically between sites, in some cases, the environmental benefits were limited despite the significant economic burden of those renewable systems on-site and vice versa. Our recommendation for GBRSs, and broader policies and regulations, is to require buildings with higher environmental impacts to achieve higher levels of energy performance and on-site renewable energy utilization, instead of fixed percentages.

  9. FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal

    Directory of Open Access Journals (Sweden)

    Suchitra D. Gopinath

    2014-04-01

    Full Text Available Skeletal muscle stem cells, or “satellite cells” (SCs, are required for the regeneration of damaged muscle tissue. Although SCs self-renew during regeneration, the mechanisms that govern SC re-entry into quiescence remain elusive. We show that FOXO3, a member of the forkhead family of transcription factors, is expressed in quiescent SCs (QSCs. Conditional deletion of Foxo3 in QSCs impairs self-renewal and increases the propensity of SCs to adopt a differentiated fate. Transcriptional analysis of SCs lacking FOXO3 revealed a downregulation of Notch signaling, a key regulator of SC quiescence. Conversely, overexpression of Notch intracellular domain (NICD rescued the self-renewal deficit of FOXO3-deficient SCs. We show that FOXO3 regulates NOTCH1 and NOTCH3 receptor expression and that decreasing expression of NOTCH1 and NOTCH3 receptors phenocopies the effect of FOXO3 deficiency in SCs. We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration.

  10. Discovery of Power-Law Growth in the Self-Renewal of Heterogeneous Glioma Stem Cell Populations.

    Directory of Open Access Journals (Sweden)

    Michiya Sugimori

    Full Text Available Accumulating evidence indicates that cancer stem cells (CSCs drive tumorigenesis. This suggests that CSCs should make ideal therapeutic targets. However, because CSC populations in tumors appear heterogeneous, it remains unclear how CSCs might be effectively targeted. To investigate the mechanisms by which CSC populations maintain heterogeneity during self-renewal, we established a glioma sphere (GS forming model, to generate a population in which glioma stem cells (GSCs become enriched. We hypothesized, based on the clonal evolution concept, that with each passage in culture, heterogeneous clonal sublines of GSs are generated that progressively show increased proliferative ability.To test this hypothesis, we determined whether, with each passage, glioma neurosphere culture generated from four different glioma cell lines become progressively proliferative (i.e., enriched in large spheres. Rather than monitoring self-renewal, we measured heterogeneity based on neurosphere clone sizes (#cells/clone. Log-log plots of distributions of clone sizes yielded a good fit (r>0.90 to a straight line (log(% total clones = k*log(#cells/clone indicating that the system follows a power-law (y = xk with a specific degree exponent (k = -1.42. Repeated passaging of the total GS population showed that the same power-law was maintained over six passages (CV = -1.01 to -1.17. Surprisingly, passage of either isolated small or large subclones generated fully heterogeneous populations that retained the original power-law-dependent heterogeneity. The anti-GSC agent Temozolomide, which is well known as a standard therapy for glioblastoma multiforme (GBM, suppressed the self-renewal of clones, but it never disrupted the power-law behavior of a GS population.Although the data above did not support the stated hypothesis, they did strongly suggest a novel mechanism that underlies CSC heterogeneity. They indicate that power-law growth governs the self-renewal of heterogeneous

  11. Economic Justification of Concentrating Solar Power in High Renewable Energy Penetrated Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    Hodge, Brian S [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kroposki, Benjamin D [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Du, Ershun [Tsinghua University; Zhang, Ning [Tsinghua University; Kang, Chongqing [Tsinghua University; Xia, Qing [Tsinghua University

    2018-04-24

    Concentrating solar power (CSP) plants are able to provide both renewable energy and operational flexibility at the same time due to its thermal energy storage (TES). It is ideal generation to power systems lacking in flexibility to accommodate variable renewable energy (VRE) generation such as wind power and photovoltaics. However, its investment cost currently is too high to justify its benefit in terms of providing renewable energy only. In this paper we evaluate the economic benefit of CSP in high renewable energy penetrated power systems from two aspects: generating renewable energy and providing operational flexibility to help accommodating VRE. In order to keep the same renewable energy penetration level during evaluation, we compare the economic costs between the system with a high share of VRE and another in which some part of the VRE generation is replaced by CSP generation. The generation cost of a power system is analyzed through chronological operation simulation over a whole year. The benefit of CSP is quantified into two parts: (1) energy benefit - the saving investment of substituted VRE generation and (2) flexibility benefit - the reduction in operating cost due to substituting VRE with CSP. The break-even investment cost of CSP is further discussed. The methodology is tested on a modified IEEE RTS-79 system. The economic justifications of CSP are demonstrated in two practical provincial power systems with high penetration of renewable energy in northwestern China, Qinghai and Gansu, where the former province has massive inflexible thermal power plants but later one has high share of flexible hydro power. The results suggest that the CSP is more beneficial in Gansu system than in Qinghai. The levelized benefit of CSP, including both energy benefit and flexibility benefit, is about 0.177-0.191 $/kWh in Qinghai and about 0.238-0.300 $/kWh in Gansu, when replacing 5-20% VRE generation with CSP generation.

  12. Neutral dynamics and cell renewal of colonic crypts in homeostatic regime

    Science.gov (United States)

    Fendrik, A. J.; Romanelli, L.; Rotondo, E.

    2018-05-01

    The self renewal process in colonic crypts is the object of several studies. We present here a new compartment model with the following characteristics: (a) we distinguish different classes of cells: stem cells, six generations of transit amplifying cells and the differentiated cells; (b) in order to take into account the monoclonal character of crypts in homeostatic regimes we include symmetric divisions of the stem cells. We first consider the dynamic differential equations that describe the evolution of the mean values of the populations, but the small observed value of the total number of cells involved plus the huge dispersion of experimental data found in the literature leads us to study the stochastic discrete process. This analysis allows us to study fluctuations, the neutral drift that leads to monoclonality, and the effects of the fixation of mutant clones.

  13. Compilation and review of methodologies for estimating the comparative electric power system costs for renewable energy systems. Working material

    International Nuclear Information System (INIS)

    1993-01-01

    This Working Material provides a review of methodologies for estimating the costs of renewable energy systems and the state of art knowledge on stochastic features and economic evaluation methodologies of renewable energy systems for electricity generation in a grid integrated system. It is expected that this material facilitates the wider access by interested persons to sources for relevant comparative assessment activities which are progressing in the IAEA. Refs, figs, tabs

  14. Nuclear Energy and Renewables: System Effects in Low-carbon Electricity Systems : Method comments to a NEA report

    OpenAIRE

    Söder, Lennart

    2012-01-01

    OECD Nuclear Energy Agency (NEA) released a new report on 29 November 2012. The study recommends that decision-makers should take full electricity system costs into account in energy choices and that such costs should be internalised according to a “generator pays” principle. The study, entitled Nuclear Energy and Renewables: System Effects in Low-carbon Electricity Systems, addresses the increasingly important interactions of variable renewables and dispatchable energy technologies, such as ...

  15. The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells.

    Science.gov (United States)

    Huang, Xinxin; Tian, E; Xu, Yanhua; Zhang, Hong

    2009-09-15

    Stem cells undergo symmetric and asymmetric division to maintain the dynamic equilibrium of the stem cell pool and also to generate a variety of differentiated cells. The homeostatic mechanism controlling the choice between self-renewal and differentiation of stem cells is poorly understood. We show here that ceh-16, encoding the C. elegans ortholog of the transcription factor Engrailed, controls symmetric and asymmetric division of stem cell-like seam cells. Loss of function of ceh-16 causes certain seam cells, which normally undergo symmetric self-renewal expansion division with both daughters adopting the seam cell fate, to divide asymmetrically with only one daughter retaining the seam cell fate. The human engrailed homolog En2 functionally substitutes the role of ceh-16 in promoting self-renewal expansion division of seam cells. Loss of function of apr-1, encoding the C. elegans homolog of the Wnt signaling component APC, results in transformation of self-renewal maintenance seam cell division to self-renewal expansion division, leading to seam cell hyperplasia. The apr-1 mutation suppresses the seam cell division defect in ceh-16 mutants. Our study reveals that ceh-16 interacts with the Wnt signaling pathway to control the choice between self-renewal expansion and maintenance division and also demonstrates an evolutionarily conserved function of engrailed in promoting cell proliferation.

  16. Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche

    Directory of Open Access Journals (Sweden)

    Heather A. Himburg

    2012-10-01

    Full Text Available The mechanisms through which the bone marrow (BM microenvironment regulates hematopoietic stem cell (HSC fate remain incompletely understood. We examined the role of the heparin-binding growth factor pleiotrophin (PTN in regulating HSC function in the niche. PTN−/− mice displayed significantly decreased BM HSC content and impaired hematopoietic regeneration following myelosuppression. Conversely, mice lacking protein tyrosine phosphatase receptor zeta, which is inactivated by PTN, displayed significantly increased BM HSC content. Transplant studies revealed that PTN action was not HSC autonomous, but rather was mediated by the BM microenvironment. Interestingly, PTN was differentially expressed and secreted by BM sinusoidal endothelial cells within the vascular niche. Furthermore, systemic administration of anti-PTN antibody in mice substantially impaired both the homing of hematopoietic progenitor cells to the niche and the retention of BM HSCs in the niche. PTN is a secreted component of the BM vascular niche that regulates HSC self-renewal and retention in vivo.

  17. Power Electronics – Key Technology for Renewable Energy Systems – Status and Future

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Yang, Yongheng; Ma, Ke

    2013-01-01

    play an essential role. Using highly efficient power electronics in power generation, power transmission/ distribution and end-user application, together with advanced control solutions, can pave the way for renewable energies. In view of this, some of the most emerging renewable energies, e.g. wind......The energy paradigms in many countries (e.g. Germany and Denmark) have experienced a significant change from fossil-based resources to clean renewables in the past few decades. The scenario of highly penetrated renewables is going to be further enhanced. This requires that the production......, distribution and use of the energy should be as technological efficient as possible and incentives to save energy at the end-user should also be streng-thened. In order to realize the transition smoothly and effectively, energy conversion systems, currently based on power electronics technology, will again...

  18. The Economic Potential of Three Nuclear-Renewable Hybrid Energy Systems Providing Thermal Energy to Industry

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Mark [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cutler, Dylan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Flores-Espino, Francisco [National Renewable Energy Lab. (NREL), Golden, CO (United States); Stark, Greg [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jenkin, Thomas [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-12-01

    This report is one of a series of reports that Idaho National Laboratory and National Renewable Energy Laboratory are producing to investigate the technical and economic aspects of nuclear-renewable hybrid energy systems (N-R HESs). Previous reports provided results of an analysis of two N-R HES scenarios. This report builds that analysis with a Texas-synthetic gasoline scenario providing the basis in which the N-R HES sells heat directly to an industrial customer. Subsystems were included that convert electricity to heat, thus allowing the renewable energy subsystem to generate heat and benefit from that revenue stream. Nuclear and renewable energy sources are important to consider in the energy sector's evolution because both are considered to be clean and non-carbon-emitting energy sources.

  19. The Economic Potential of Three Nuclear-Renewable Hybrid Energy Systems Providing Thermal Energy to Industry

    International Nuclear Information System (INIS)

    Ruth, Mark; Cutler, Dylan; Flores-Espino, Francisco; Stark, Greg; Jenkin, Thomas

    2016-01-01

    This report is one of a series of reports that Idaho National Laboratory and National Renewable Energy Laboratory are producing to investigate the technical and economic aspects of nuclear-renewable hybrid energy systems (N-R HESs). Previous reports provided results of an analysis of two N-R HES scenarios. This report builds that analysis with a Texas-synthetic gasoline scenario providing the basis in which the N-R HES sells heat directly to an industrial customer. Subsystems were included that convert electricity to heat, thus allowing the renewable energy subsystem to generate heat and benefit from that revenue stream. Nuclear and renewable energy sources are important to consider in the energy sector's evolution because both are considered to be clean and non-carbon-emitting energy sources.

  20. SIMULATION OF THE SYSTEMS WITH RENEWABLE ENERGY SOURCES USING HOMER SOFTWARE

    Directory of Open Access Journals (Sweden)

    FIRINCĂ S.D.

    2015-12-01

    Full Text Available This paper simulates by using the Homer software, distributed energy systems with capacity below 1 MW. Among the renewable energy sources are used wind and solar energy. For photovoltaic panels, we are considering two situations: fixed panels, oriented at 45 ° and panels with tracking system with two axis. Simulation results contain information regarding operation hours of the system throughout the year, energy produced from the renewable energy sources, energy consumption for the load, and excess of electrical energy. The Homer software also allows an economic analysis of these systems.

  1. Transient Stability Assessment of Power Systems With Uncertain Renewable Generation: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Villegas Pico, Hugo Nestor [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Aliprantis, Dionysios C. [Purdue University; Lin, Xiaojun [Purdue University

    2017-08-09

    The transient stability of a power system depends heavily on its operational state at the moment of a fault. In systems where the penetration of renewable generation is significant, the dispatch of the conventional fleet of synchronous generators is uncertain at the time of dynamic security analysis. Hence, the assessment of transient stability requires the solution of a system of nonlinear ordinary differential equations with unknown initial conditions and inputs. To this end, we set forth a computational framework that relies on Taylor polynomials, where variables are associated with the level of renewable generation. This paper describes the details of the method and illustrates its application on a nine-bus test system.

  2. SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells.

    Science.gov (United States)

    Santini, R; Pietrobono, S; Pandolfi, S; Montagnani, V; D'Amico, M; Penachioni, J Y; Vinci, M C; Borgognoni, L; Stecca, B

    2014-09-18

    Melanoma is one of the most aggressive types of human cancer, characterized by enhanced heterogeneity and resistance to conventional therapy at advanced stages. We and others have previously shown that HEDGEHOG-GLI (HH-GLI) signaling is required for melanoma growth and for survival and expansion of melanoma-initiating cells (MICs). Recent reports indicate that HH-GLI signaling regulates a set of genes typically expressed in embryonic stem cells, including SOX2 (sex-determining region Y (SRY)-Box2). Here we address the function of SOX2 in human melanomas and MICs and its interaction with HH-GLI signaling. We find that SOX2 is highly expressed in melanoma stem cells. Knockdown of SOX2 sharply decreases self-renewal in melanoma spheres and in putative melanoma stem cells with high aldehyde dehydrogenase activity (ALDH(high)). Conversely, ectopic expression of SOX2 in melanoma cells enhances their self-renewal in vitro. SOX2 silencing also inhibits cell growth and induces apoptosis in melanoma cells. In addition, depletion of SOX2 progressively abrogates tumor growth and leads to a significant decrease in tumor-initiating capability of ALDH(high) MICs upon xenotransplantation, suggesting that SOX2 is required for tumor initiation and for continuous tumor growth. We show that SOX2 is regulated by HH signaling and that the transcription factors GLI1 and GLI2, the downstream effectors of HH-GLI signaling, bind to the proximal promoter region of SOX2 in primary melanoma cells. In functional studies, we find that SOX2 function is required for HH-induced melanoma cell growth and MIC self-renewal in vitro. Thus SOX2 is a critical factor for self-renewal and tumorigenicity of MICs and an important mediator of HH-GLI signaling in melanoma. These findings could provide the basis for novel therapeutic strategies based on the inhibition of SOX2 for the treatment of a subset of human melanomas.

  3. Power fluctuation reduction methodology for the grid-connected renewable power systems

    Science.gov (United States)

    Aula, Fadhil T.; Lee, Samuel C.

    2013-04-01

    This paper presents a new methodology for eliminating the influence of the power fluctuations of the renewable power systems. The renewable energy, which is to be considered an uncertain and uncontrollable resource, can only provide irregular electrical power to the power grid. This irregularity creates fluctuations of the generated power from the renewable power systems. These fluctuations cause instability to the power system and influence the operation of conventional power plants. Overall, the power system is vulnerable to collapse if necessary actions are not taken to reduce the impact of these fluctuations. This methodology aims at reducing these fluctuations and makes the generated power capability for covering the power consumption. This requires a prediction tool for estimating the generated power in advance to provide the range and the time of occurrence of the fluctuations. Since most of the renewable energies are weather based, as a result a weather forecast technique will be used for predicting the generated power. The reduction of the fluctuation also requires stabilizing facilities to maintain the output power at a desired level. In this study, a wind farm and a photovoltaic array as renewable power systems and a pumped-storage and batteries as stabilizing facilities are used, since they are best suitable for compensating the fluctuations of these types of power suppliers. As an illustrative example, a model of wind and photovoltaic power systems with battery energy and pumped hydro storage facilities for power fluctuation reduction is included, and its power fluctuation reduction is verified through simulation.

  4. A Transition Strategy from Fossil Fuels to Renewable Energy Sources in the Mexican Electricity System

    Directory of Open Access Journals (Sweden)

    Juan J. Vidal-Amaro

    2018-03-01

    Full Text Available Renewable energy sources exploitation acquires special importance for creating low-carbon energy systems. In Mexico a national regulation limits the fossil fuel-based electricity generation to 65%, 60% and 50% by years 2024, 2030 and 2050 respectively. This study evaluates several scenarios of renewables incorporation into the Mexican electricity system to attend those targets as well as a 75% renewables-based electricity share target towards a 100% renewable system. By its size, the Mexican electricity system, with a generation of 260.4 TWh/year (85% based on fossil fuels, can be regarded as an illustrating reference. The impact of increasing amounts of wind, photovoltaic solar, biomass, biogas, geothermal, hydro and concentrating solar power on the system’s capacity to attend demand on a one-hour timescale resolution is investigated utilizing the EnergyPLAN model and the minimum total mix capacity method. Possible excess of electricity production is also assessed. For every target year, a solution is obtained corresponding to the combination resulting in the minimum total generation capacity for the electricity system. A transition strategy to a system with a high share of renewables-based electricity is designed where every transition step corresponds to the optimal energy mix for each of the target years.

  5. Reliability assessment of distribution system with the integration of renewable distributed generation

    International Nuclear Information System (INIS)

    Adefarati, T.; Bansal, R.C.

    2017-01-01

    Highlights: • Addresses impacts of renewable DG on the reliability of the distribution system. • Multi-objective formulation for maximizing the cost saving with integration of DG. • Uses Markov model to study the stochastic characteristics of the major components. • The investigation is done using modified RBTS bus test distribution system. • Proposed approach is useful for electric utilities to enhance the reliability. - Abstract: Recent studies have shown that renewable energy resources will contribute substantially to future energy generation owing to the rapid depletion of fossil fuels. Wind and solar energy resources are major sources of renewable energy that have the ability to reduce the energy crisis and the greenhouse gases emitted by the conventional power plants. Reliability assessment is one of the key indicators to measure the impact of the renewable distributed generation (DG) units in the distribution networks and to minimize the cost that is associated with power outage. This paper presents a comprehensive reliability assessment of the distribution system that satisfies the consumer load requirements with the penetration of wind turbine generator (WTG), electric storage system (ESS) and photovoltaic (PV). A Markov model is proposed to access the stochastic characteristics of the major components of the renewable DG resources as well as their influence on the reliability of a conventional distribution system. The results obtained from the case studies have demonstrated the effectiveness of using WTG, ESS and PV to enhance the reliability of the conventional distribution system.

  6. Transition from non-renewable to renewable energy sources: fuel cells in Antarctica as an economically attractive niche

    International Nuclear Information System (INIS)

    Marschoff, C.M.

    1998-01-01

    There is a growing amount of evidence that indicates that fuel cells might be commercially attractive in several market niches in Latin America; however, political approval of demonstration projects has been elusive. In this paper, the results of an economic study carried out on the assumption of introducing an environmentally friendly fuel, such as methanol, for feeding fuel cell systems for electricity generation and heat production in the six bases that Argentina has in Antarctica are reported. It is seen that, in this particular case, there is a net cost benefit, even if the assets resulting from diminishing pollution in Antarctica are not taken into account. (Author)

  7. Test programme `Solgaarden`, Kolding. 1. Solar cell system located in an urban renewal district. 2. Prefabricated, built-in elevators for an older, occupied block of flats; Forsoegsprogram Solgaarden, Kolding. 1. Solcelleanlaeg i et byfornyelsesomraade. 2. Praefabrikerede elevatorer til indbygning i en beboet aeldre etageejendom

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    The aim was to promote the use of photovoltaic power systems in Denmark by setting up such a system for preliminary performance testing in a district undergoing urban renewal in the Danish town of Kolding in Jutland. This area, and the renewal initiatives taken, are described in addition to the photovoltaic units positioned on the roof and on the balconies of an older apartment building in the area. The brief descriptive texts are illustrated with a considerable number of diagrams and photographs. (AB)

  8. Battery energy storage systems: Assessment for small-scale renewable energy integration

    Energy Technology Data Exchange (ETDEWEB)

    Nair, Nirmal-Kumar C.; Garimella, Niraj [Power Systems Group, Department of Electrical and Computer Engineering, The University of Auckland, 38 Princes Street, Science Centre, Auckland 1142 (New Zealand)

    2010-11-15

    Concerns arising due to the variability and intermittency of renewable energy sources while integrating with the power grid can be mitigated to an extent by incorporating a storage element within the renewable energy harnessing system. Thus, battery energy storage systems (BESS) are likely to have a significant impact in the small-scale integration of renewable energy sources into commercial building and residential dwelling. These storage technologies not only enable improvements in consumption levels from renewable energy sources but also provide a range of technical and monetary benefits. This paper provides a modelling framework to be able to quantify the associated benefits of renewable resource integration followed by an overview of various small-scale energy storage technologies. A simple, practical and comprehensive assessment of battery energy storage technologies for small-scale renewable applications based on their technical merit and economic feasibility is presented. Software such as Simulink and HOMER provides the platforms for technical and economic assessments of the battery technologies respectively. (author)

  9. Expression dynamics of self-renewal factors for spermatogonial stem cells in the mouse testis.

    Science.gov (United States)

    Sakai, Mizuki; Masaki, Kaito; Aiba, Shota; Tone, Masaaki; Takashima, Seiji

    2018-04-16

    Glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are bona fide self-renewal factors for spermatogonial stem cells (SSCs). Although GDNF is indispensable for the maintenance of SSCs, the role of FGF2 in the testis remains to be elucidated. To clarify this, the expression dynamics and regulatory mechanisms of Fgf2 and Gdnf in the mouse testes were analyzed. It is well known that Sertoli cells express Gdnf, and its receptor is expressed in a subset of undifferentiated spermatogonia, including SSCs. However, we found that Fgf2 was mainly expressed in the germ cells and its receptors were expressed not only in the cultured spermatogonial cell line, but also in testicular somatic cells. Aging, hypophysectomy, retinoic acid treatment, and testicular injury induced distinct Fgf2 and Gdnf expression dynamics, suggesting a difference in the expression mechanism of Fgf2 and Gdnf in the testis. Such differences might cause a dynamic fluctuation of Gdnf/Fgf2 ratio depending on the intrinsic/extrinsic cues. Considering that FGF2-cultured spermatogonia exhibit more differentiated phenotype than those cultured with GDNF, FGF2 might play a role distinct from that of GDNF in the testis, despite the fact that both factors are self-renewal factor for SSC in vitro.

  10. Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity

    International Nuclear Information System (INIS)

    Gatti, Monica; Pattarozzi, Alessandra; Bajetto, Adriana; Würth, Roberto; Daga, Antonio; Fiaschi, Pietro; Zona, Gianluigi; Florio, Tullio; Barbieri, Federica

    2013-01-01

    Cancer stem cells (CSCs) or tumor initiating cells (TICs) drive glioblastoma (GBM) development, invasiveness and drug resistance. Distinct molecular pathways might regulate CSC biology as compared to cells in the bulk tumor mass, representing potential therapeutic targets. Chemokine CXCL12 and its receptor CXCR4 control proliferation, invasion and angiogenesis in GBM cell lines and primary cultures, but little is known about their activity in GBM CSCs. We demonstrate that CSCs, isolated from five human GBMs, express CXCR4 and release CXCL12 in vitro, although different levels of expression and secretion were observed in individual cultures, as expected for the heterogeneity of GBMs. CXCL12 treatment induced Akt-mediated significant pro-survival and self-renewal activities, while proliferation was induced at low extent. The role of CXCR4 signaling in CSC survival and self-renewal was further demonstrated using the CXCR4 antagonist AMD3100 that reduced self-renewal and survival with greater efficacy in the cultures that released higher CXCL12 amounts. The specificity of CXCL12 in sustaining CSC survival was demonstrated by the lack of AMD3100-dependent inhibition of viability in differentiated cells derived from the same GBMs. These findings, although performed on a limited number of tumor samples, suggest that the CXCL12/CXCR4 interaction mediates survival and self-renewal in GBM CSCs with high selectivity, thus emerging as a candidate system responsible for maintenance of cancer progenitors, and providing survival benefits to the tumor

  11. The Concept of Autonomous Power Supply System Fed with Renewable Energy Sources

    Directory of Open Access Journals (Sweden)

    Waldemar Fedak

    2017-12-01

    Full Text Available Sustainable economic development requires the use of renewable energy sources in a rational and thoughtful way. In Polish conditions the use of several types of renewable energy sources on a single setup is a new issue. In particular, hybrid devices in conjunction with intelligent energy systems, such as lighting systems are generally not used. Therefore, the Polish energy production still relies on the burning of coal. Despite their advantages, renewable energy sources are characterized by seasonality and considerable instability. Access to renewable energy varies daily and seasonally, hence activities promoting the use of autonomous, hybrid power systems must be intensified. The presented research aims at the development of the Autonomous Power Supply (APS system based on the so-called energy mix. Such a system works in an isolated arrangement and serves to reliably supply electricity from renewable sources for small residential or public utility devices in an urban area. Systems with up to 3 kW power consist of modules, whose modular design allows the combination of various power configurations and types of renewable energy used. The basic system consists of a primary power source, additional power source, emergency power source, energy storage device, weather station and controller. The energy mix depends on the geographical location of the system. The emergency source can be implemented as an on-grid connector or fuel power generator with the participation of 100% until the primary or accessory power source failure is removed. The energy storage system consists of batteries or supercapacitors. The proposed system can be combined to create a local network that automatically responds to energy shortages in various network nodes by adjusting the supply of electricity within the network depending on its needs. For Poland realistic solutions in this article are the new and modern answer to these requirements.

  12. Niche-independent symmetrical self-renewal of a mammalian tissue stem cell.

    Directory of Open Access Journals (Sweden)

    Luciano Conti

    2005-09-01

    Full Text Available Pluripotent mouse embryonic stem (ES cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions. Ex vivo expansion of pure populations of tissue stem cells has proven elusive. Neural progenitor cells are propagated in combination with differentiating progeny in floating clusters called neurospheres. The proportion of stem cells in neurospheres is low, however, and they cannot be directly observed or interrogated. Here we demonstrate that the complex neurosphere environment is dispensable for stem cell maintenance, and that the combination of fibroblast growth factor 2 (FGF-2 and epidermal growth factor (EGF is sufficient for derivation and continuous expansion by symmetrical division of pure cultures of neural stem (NS cells. NS cells were derived first from mouse ES cells. Neural lineage induction was followed by growth factor addition in basal culture media. In the presence of only EGF and FGF-2, resulting NS cells proliferate continuously, are diploid, and clonogenic. After prolonged expansion, they remain able to differentiate efficiently into neurons and astrocytes in vitro and upon transplantation into the adult brain. Colonies generated from single NS cells all produce neurons upon growth factor withdrawal. NS cells uniformly express morphological, cell biological, and molecular features of radial glia, developmental precursors of neurons and glia. Consistent with this profile, adherent NS cell lines can readily be established from foetal mouse brain. Similar NS cells can be generated from human ES cells and human foetal brain. The extrinsic factors EGF plus FGF-2 are sufficient to sustain pure symmetrical self-renewing divisions of NS cells. The resultant cultures constitute the first known example of tissue-specific stem cells that can be propagated without accompanying

  13. Energy–exergy and economic analyses of a hybrid solar–hydrogen renewable energy system in Ankara, Turkey

    International Nuclear Information System (INIS)

    Ozden, Ender; Tari, Ilker

    2016-01-01

    Highlights: • Uninterrupted energy in an emergency blackout situation. • System modeling of a solar–hydrogen based hybrid renewable energy system. • A comprehensive thermodynamical analysis. • Levelized cost of electricity analysis for a project lifetime of 25 years. - Abstract: A hybrid (Solar–Hydrogen) stand-alone renewable energy system that consists of photovoltaic panels (PV), Proton Exchange Membrane (PEM) fuel cells, PEM based electrolyzers and hydrogen storage is investigated by developing a complete model of the system using TRNSYS. The PV panels are mounted on a tiltable platform to improve the performance of the system by monthly adjustments of the tilt angle. The total area of the PV panels is 300 m 2 , the PEM fuel cell capacity is 5 kW, and the hydrogen storage is at 55 bars pressure and with 45 m 3 capacity. The main goal of this study is to verify that the system meets the electrical power demand of the emergency room without experiencing a shortage for a complete year in an emergency blackout situation. For this purpose, after modeling the system, energy and exergy analyses for the hydrogen cycle of the system for a complete year are performed, and the energy and exergy efficiencies are found as 4.06% and 4.25%, respectively. Furthermore, an economic analysis is performed for a project lifetime of 25 years based on Levelized Cost of Electricity (LCE), and the LCE is calculated as 0.626 $/kWh.

  14. Simplified Method of Optimal Sizing of a Renewable Energy Hybrid System for Schools

    Directory of Open Access Journals (Sweden)

    Jiyeon Kim

    2016-11-01

    Full Text Available Schools are a suitable public building for renewable energy systems. Renewable energy hybrid systems (REHSs have recently been introduced in schools following a new national regulation that mandates renewable energy utilization. An REHS combines the common renewable-energy sources such as geothermal heat pumps, solar collectors for water heating, and photovoltaic systems with conventional energy systems (i.e., boilers and air-source heat pumps. Optimal design of an REHS by adequate sizing is not a trivial task because it usually requires intensive work including detailed simulation and demand/supply analysis. This type of simulation-based approach for optimization is difficult to implement in practice. To address this, this paper proposes simplified sizing equations for renewable-energy systems of REHSs. A conventional optimization process is used to calculate the optimal combinations of an REHS for cases of different numbers of classrooms and budgets. On the basis of the results, simplified sizing equations that use only the number of classrooms as the input are proposed by regression analysis. A verification test was carried out using an initial conventional optimization process. The results show that the simplified sizing equations predict similar sizing results to the initial process, consequently showing similar capital costs within a 2% error.

  15. Role of renewable energy policies in energy dependency in Finland: System dynamics approach

    International Nuclear Information System (INIS)

    Aslani, Alireza; Helo, Petri; Naaranoja, Marja

    2014-01-01

    Highlights: • A system dynamics model for evaluating renewable energy policies on dependency is proposed. • The model considers the role of diversification on dependency and security of energy supply in Finland. • Dependency on imported sources will decrease depends on the defined scenarios in Finland. - Abstract: Objective: We discuss the role of diversification on dependency and security of energy supply. A system dynamics model with especial focus on the role of renewable energy resources (as a portfolio) on Finland’s energy dependency is developed. The purpose is also to cover a part of research gap exists in the system dynamics modeling of energy security investigations. Methods: A causal loops diagram and a system dynamics model evaluate Finnish scenarios of renewable energy policies. The analysis describes the relationship between dynamic factors such as RE encouragement packages, dependency, and energy demand. Results: A causal loops diagram and a system dynamics model evaluate three different Finnish scenarios of renewable energy policies by 2020. Conclusion: Analysis shows that despite 7% electricity/heat consumption growth by 2020 in Finland, dependency on imported sources will decrease between 1% and 7% depend on the defined scenarios. Practice Implications: The proposed model not only helps decision makers to test their scenarios related to renewable energy polices, it can be implemented by other countries

  16. Power control based on particle swarm optimization of grid-connected inverter for hybrid renewable energy system

    International Nuclear Information System (INIS)

    García-Triviño, Pablo; Gil-Mena, Antonio José; Llorens-Iborra, Francisco; García-Vázquez, Carlos Andrés; Fernández-Ramírez, Luis M.; Jurado, Francisco

    2015-01-01

    Highlights: • Three PSO-based PI controllers for a grid-connected inverter were presented. • Two online PSO-based PI controllers were compared with an offline PSO-tuned PI. • The HRES and the inverter were evaluated under power changes and grid voltage sags. • Online ITAE-based PSO reduced ITAE (current THD) by 15.24% (5.32%) versus offline one. - Abstract: This paper is focused on the study of particle swarm optimization (PSO)-based PI controllers for the power control of a grid-connected inverter supplied from a hybrid renewable energy system. It is composed of two renewable energy sources (wind turbine and photovoltaic – PV – solar panels) and two energy storage systems (battery and hydrogen system, integrated by fuel cell and electrolyzer). Three PSO-based PI controllers are implemented: (1) conventional PI controller with offline tuning by PSO algorithm based on the integral time absolute error (ITAE) index; (2) PI controllers with online self-tuning by PSO algorithm based on the error; and (3) PI controllers with online self-tuning by PSO algorithm based on the ITAE index. To evaluate and compare the three controllers, the hybrid renewable energy system and the grid-connected inverter are simulated under changes in the active and reactive power values, as well as under a grid voltage sag. The results show that the online PSO-based PI controllers that optimize the ITAE index achieves the best response

  17. Quantitation and renewal of alveolar and bronchiolar cell populations of rat lungs. Changes during some pathological processes

    International Nuclear Information System (INIS)

    Fritsch, Paul.

    1979-02-01

    The various cells of alveolar and bronchiolar tissues of rat lungs were studied qualitatively and quantitatively. In physiological conditions, the renewal rate of the cell populations is low and the frequency of the various cell types is constant. This stability, especially at the level of the alveolar tissue, was also found during the latency period and the development of radiation-induced lung cancers. A particular cellular population was demonstrated: marginated leukocyte pool at the level of the pulmonary circulation. This pool was different both qualitatively and quantitatively from the leukocytes of the systemic circulation and, in physiological conditions, behaved as a cellular reservoir of monocytes chiefly re-distributed according to the body needs. In pathological conditions, its fast migration contributed to the defence of the alveolar medium. A quantitative study of the renewal of alveolar macrophages showed that under 1 p. cent of the marginated leukocyte pool is used daily to keep up this population. This fraction undergoes a maturation stage by cellular division within the endoalveolar medium. In some pathological conditions, this division can be completely inhibited [fr

  18. Hybrid PV/Wind Power Systems Incorporating Battery Storage and Considering the Stochastic Nature of Renewable Resources

    Science.gov (United States)

    Barnawi, Abdulwasa Bakr

    Hybrid power generation system and distributed generation technology are attracting more investments due to the growing demand for energy nowadays and the increasing awareness regarding emissions and their environmental impacts such as global warming and pollution. The price fluctuation of crude oil is an additional reason for the leading oil producing countries to consider renewable resources as an alternative. Saudi Arabia as the top oil exporter country in the word announced the "Saudi Arabia Vision 2030" which is targeting to generate 9.5 GW of electricity from renewable resources. Two of the most promising renewable technologies are wind turbines (WT) and photovoltaic cells (PV). The integration or hybridization of photovoltaics and wind turbines with battery storage leads to higher adequacy and redundancy for both autonomous and grid connected systems. This study presents a method for optimal generation unit planning by installing a proper number of solar cells, wind turbines, and batteries in such a way that the net present value (NPV) is minimized while the overall system redundancy and adequacy is maximized. A new renewable fraction technique (RFT) is used to perform the generation unit planning. RFT was tested and validated with particle swarm optimization and HOMER Pro under the same conditions and environment. Renewable resources and load randomness and uncertainties are considered. Both autonomous and grid-connected system designs were adopted in the optimal generation units planning process. An uncertainty factor was designed and incorporated in both autonomous and grid connected system designs. In the autonomous hybrid system design model, the strategy including an additional amount of operation reserve as a percent of the hourly load was considered to deal with resource uncertainty since the battery storage system is the only backup. While in the grid-connected hybrid system design model, demand response was incorporated to overcome the impact of

  19. A 100% renewable power system for Europe - Let the weather and physics decide!

    DEFF Research Database (Denmark)

    Greiner, Martin; Heide, Dominik; Rasmussen, Morten Grud

    The design of sustainable energy systems is no longer only the domain of politics, economics and engineering. Mathematical physics is able to contribute with its generic understanding of everything. A new modeling approach is presented and applied to design a fully renewable European power system....... This approach is based on weather data with good spatio-temporal resolution, which is first converted into wind and solar power generation and then used to derive estimates on the optimal mix between the renewable resources and the storage needs.......The design of sustainable energy systems is no longer only the domain of politics, economics and engineering. Mathematical physics is able to contribute with its generic understanding of everything. A new modeling approach is presented and applied to design a fully renewable European power system...

  20. Generic Energy Matching Model and Figure of Matching Algorithm for Combined Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    J.C. Brezet

    2009-08-01

    Full Text Available In this paper the Energy Matching Model and Figure of Matching Algorithm which originally was dedicated only to photovoltaic (PV systems [1] are extended towards a Model and Algorithm suitable for combined systems which are a result of integration of two or more renewable energy sources into one. The systems under investigation will range from mobile portable devices up to the large renewable energy system conceivably to be applied at the Afsluitdijk (Closure- dike in the north of the Netherlands. This Afsluitdijk is the major dam in the Netherlands, damming off the Zuiderzee, a salt water inlet of the North Sea and turning it into the fresh water lake of the IJsselmeer. The energy chain of power supplies based on a combination of renewable energy sources can be modeled by using one generic Energy Matching Model as starting point.

  1. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells

    Science.gov (United States)

    Butler, Jason M.; Nolan, Daniel J.; L.Vertes, Eva; Varnum-Finney, Barbara; Kobayashi, Hideki; Hooper, Andrea T.; Seandel, Marco; Shido, Koji; White, Ian A.; Kobayashi, Mariko; Witte, Larry; May, Chad; Shawber, Carrie; Kimura, Yuki; Kitajewski, Jan; Rosenwaks, Zev; Bernstein, Irwin D.; Rafii, Shahin

    2010-01-01

    Bone marrow endothelial cells (ECs) are essential for reconstitution of hematopoiesis, but their role in self-renewal of long term-hematopoietic stem cells (LT-HSCs) is unknown. We have developed angiogenic models to demonstrate that EC-derived angiocrine growth factors support in vitro self-renewal and in vivo repopulation of authentic LT-HSCs. In serum/cytokine-free co-cultures, ECs through direct cellular contact, stimulated incremental expansion of repopulating CD34−Flt3−cKit+Lineage−Sca1+ LT-HSCs, which retained their self-renewal ability, as determined by single cell and serial transplantation assays. Angiocrine expression of Notch-ligands by ECs promoted proliferation and prevented exhaustion of LT-HSCs derived from wild-type, but not Notch1/Notch2 deficient mice. In transgenic notch-reporter (TNR.Gfp) mice, regenerating TNR.Gfp+ LT-HSCs were detected in cellular contact with sinusoidal ECs and interfering with angiocrine, but not perfusion function, of SECs impaired repopulation of TNR.Gfp+ LT-HSCs. ECs establish an instructive vascular niche for clinical scale expansion of LT-HSCs and a cellular platform to identify stem cell-active trophogens. PMID:20207228

  2. Power quality enhancement of renewable energy source power network using SMES system

    International Nuclear Information System (INIS)

    Seo, H.R.; Kim, A.R.; Park, M.; Yu, I.K.

    2011-01-01

    Power quality enhancement of a renewable energy source power network is performed by a real-toroidal-type SMES coil. SMES unit charges and discharges the HTS coil to mitigate the fluctuation of PV system output power. The grid connected PV and SMES system has been modeled and simulated using power-hard-in-the-loop simulation. The PHILS results demonstrated the effectiveness of the SMES system for enhancing power quality. This paper deals with power quality enhancement of renewable energy source power network using SMES system and describes the operation characteristics of HTS SMES system using real-toroidal-type SMES coil for smoothening the fluctuation of large-scale renewable energy source such as photovoltaic (PV) power generation system. It generates maximum power of PV array under various weather conditions. SMES unit charges and discharges the HTS coil to mitigate the fluctuation of PV system output power. The SMES unit is controlled according to the PV array output and the utility power quality conditions. The grid connected PV and SMES system has been modeled and simulated using power-hard-in-the-loop simulation (PHILS). The PHILS results demonstrated the effectiveness of the SMES system for enhancing power quality in power network including large-scale renewable energy source, especially PV power generation system.

  3. Energy and chemicals from the selective electrooxidation of renewable diols by organometallic fuel cells.

    Science.gov (United States)

    Bellini, Marco; Bevilacqua, Manuela; Filippi, Jonathan; Lavacchi, Alessandro; Marchionni, Andrea; Miller, Hamish A; Oberhauser, Werner; Vizza, Francesco; Annen, Samuel P; Grützmacher, H

    2014-09-01

    Organometallic fuel cells catalyze the selective electrooxidation of renewable diols, simultaneously providing high power densities and chemicals of industrial importance. It is shown that the unique organometallic complex [Rh(OTf)(trop2NH)(PPh3)] employed as molecular active site in an anode of an OMFC selectively oxidizes a number of renewable diols, such as ethylene glycol , 1,2-propanediol (1,2-P), 1,3-propanediol (1,3-P), and 1,4-butanediol (1,4-B) to their corresponding mono-carboxylates. The electrochemical performance of this molecular catalyst is discussed, with the aim to achieve cogeneration of electricity and valuable chemicals in a highly selective electrooxidation from diol precursors. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Curtailment in a Highly Renewable Power System and Its Effect on Capacity Factors

    Directory of Open Access Journals (Sweden)

    Alexander Kies

    2016-06-01

    Full Text Available The capacity factor of a power plant is the ratio of generation over its potential generation. It is an important measure to describe wind and solar resources. However, the fluctuating nature of renewable power generation makes it difficult to integrate all generation at times. Whenever generation exceeds the load, curtailment or storage of energy is required. With increasing renewable shares in the power system, the level of curtailment will further increase. In this work, the influence of the curtailment on the capacity factors for a highly renewable German power system is studied. An effective capacity factor is introduced, and the implications for the distribution of renewable power plants are discussed. Three years of highly-resolved weather data were used to model wind and solar power generation. Together with historical load data and a transmission model, a possible future German power system was simulated. It is shown that effective capacity factors for unlimited transmission are strongly reduced by up to 60% (wind and 70% (photovoltaics and therefore of limited value in a highly renewable power system. Furthermore, the results demonstrate that wind power benefits more strongly from a reinforced transmission grid than photovoltaics (PV does.

  5. The integration of renewable energies into the electricity systems of North Africa

    International Nuclear Information System (INIS)

    Brand, Bernhard

    2015-01-01

    How can renewable energy sources be efficiently integrated into the North African electricity systems? By using techno-economic modeling methods, this book explores optimized electricity system expansion pathways until the year 2030 for the five North African countries - Morocco, Algeria, Tunisia, Libya and Egypt. The results indicate that renewable energy integration is actually a viable business case for the entire region, if wind and solar capacities are properly planned in conjunction with the conventional generation system and under consideration of the country-specific electricity supply-/demand patterns. Further aspects featured in this publication are the impact of renewable power on the transnational electricity transmission system and the question how decision making processes about renewable energy strategies can be improved in the North African context. The book is a contribution to the scientific literature about energy issues in the Middle East and North Africa (MENA), but also seeks to address political and industrial practitioners concerned with the development of the region's renewable energy future.

  6. The integration of renewable energies into the electricity systems of North Africa

    Energy Technology Data Exchange (ETDEWEB)

    Brand, Bernhard

    2015-11-01

    How can renewable energy sources be efficiently integrated into the North African electricity systems? By using techno-economic modeling methods, this book explores optimized electricity system expansion pathways until the year 2030 for the five North African countries - Morocco, Algeria, Tunisia, Libya and Egypt. The results indicate that renewable energy integration is actually a viable business case for the entire region, if wind and solar capacities are properly planned in conjunction with the conventional generation system and under consideration of the country-specific electricity supply-/demand patterns. Further aspects featured in this publication are the impact of renewable power on the transnational electricity transmission system and the question how decision making processes about renewable energy strategies can be improved in the North African context. The book is a contribution to the scientific literature about energy issues in the Middle East and North Africa (MENA), but also seeks to address political and industrial practitioners concerned with the development of the region's renewable energy future.

  7. Sizing of Energy Storage Systems for Output Smoothing of Renewable Energy Systems

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Renewable energy sources (RESs), such as photovoltaic (PV) and wind power generation, have the characteristics of random fluctuation and intermittence. The output of RESs should be smoothed to inhibit the adverse effects of RESs fluctuations on the power grid. The energy storage system (ESS) is playing a more and more important role in the application of RESs due to its discharge/charge characteristic. Therefore, the optimal planning and design of ESS is of vital importance because of the expensive cost of ESS.

  8. Renewable Energy

    DEFF Research Database (Denmark)

    Sørensen, Bent Erik

    Bent Sorensen’s Renewable Energy: Physics, Engineering, Environmental Impacts, Economics and Planning, Fifth Edition, continues the tradition by providing a thorough and current overview of the entire renewable energy sphere. Since its first edition, this standard reference source helped put...... renewable energy on the map of scientific agendas. Several renewable energy solutions no longer form just a marginal addition to energy supply, but have become major players, with the promise to become the backbone of an energy system suitable for life in the sustainability lane. This volume is a problem...... structured around three parts in order to assist readers in focusing on the issues that impact them the most for a given project or question. PART I covers the basic scientific principles behind all major renewable energy resources, such as solar, wind, and biomass. PART II provides in-depth information...

  9. Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Jamie Trott

    2017-06-01

    Full Text Available Pluripotent stem cells have been proposed as an unlimited source of pancreatic β cells for studying and treating diabetes. However, the long, multi-step differentiation protocols used to generate functional β cells inevitably exhibit considerable variability, particularly when applied to pluripotent cells from diverse genetic backgrounds. We have developed culture conditions that support long-term self-renewal of human multipotent pancreatic progenitors, which are developmentally more proximal to the specialized cells of the adult pancreas. These cultured pancreatic progenitor (cPP cells express key pancreatic transcription factors, including PDX1 and SOX9, and exhibit transcriptomes closely related to their in vivo counterparts. Upon exposure to differentiation cues, cPP cells give rise to pancreatic endocrine, acinar, and ductal lineages, indicating multilineage potency. Furthermore, cPP cells generate insulin+ β-like cells in vitro and in vivo, suggesting that they offer a convenient alternative to pluripotent cells as a source of adult cell types for modeling pancreatic development and diabetes.

  10. The effects of electrospun substrate-mediated cell colony morphology on the self-renewal of human induced pluripotent stem cells.

    Science.gov (United States)

    Maldonado, Maricela; Wong, Lauren Y; Echeverria, Cristina; Ico, Gerardo; Low, Karen; Fujimoto, Taylor; Johnson, Jed K; Nam, Jin

    2015-05-01

    The development of xeno-free, chemically defined stem cell culture systems has been a primary focus in the field of regenerative medicine to enhance the clinical application of pluripotent stem cells (PSCs). In this regard, various electrospun substrates with diverse physiochemical properties were synthesized utilizing various polymer precursors and surface treatments. Human induced pluripotent stem cells (IPSCs) cultured on these substrates were characterized by their gene and protein expression to determine the effects of the substrate physiochemical properties on the cells' self-renewal, i.e., proliferation and the maintenance of pluripotency. The results showed that surface chemistry significantly affected cell colony formation via governing the colony edge propagation. More importantly, when surface chemistry of the substrates was uniformly controlled by collagen conjugation, the stiffness of substrate was inversely related to the sphericity, a degree of three dimensionality in colony morphology. The differences in sphericity subsequently affected spontaneous differentiation of IPSCs during a long-term culture, implicating that the colony morphology is a deciding factor in the lineage commitment of PSCs. Overall, we show that the capability of controlling IPSC colony morphology by electrospun substrates provides a means to modulate IPSC self-renewal. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Development and commercialization of renewable energy technologies in Canada: An innovation system perspective

    International Nuclear Information System (INIS)

    Jagoda, Kalinga; Lonseth, Robert; Lonseth, Adam; Jackman, Tom

    2011-01-01

    The increased environmental awareness coupled with the recent changes in the oil prices triggered the necessity of focusing on effective management of energy systems. Global climate change has caused many people to consider ways of reducing greenhouse gases Renewable energy has become an essential feature in curtailing emission of Green House Gases, while meeting the demand for energy. This paper presents an innovation system framework for development and diffusion of renewable energy technologies. The framework is used to identify opportunities for small and medium enterprises in the renewable energy sector. A case study on a successful development, installation and implementation of solar thermal systems households in Calgary, Alberta, by an entrepreneurial firm, is also presented. (author)

  12. Development and commercialization of renewable energy technologies in Canada: An innovation system perspective

    Energy Technology Data Exchange (ETDEWEB)

    Jagoda, Kalinga; Lonseth, Robert; Lonseth, Adam [Bissett School of Business, Mount Royal University, 4825 Mount Royal Gate SW, Calgary AB T3E 6K6 (Canada); Jackman, Tom [Simple Solar Heating Limited, P.O. Box 988, Okotoks AB T1S 1B1 (Canada)

    2011-04-15

    The increased environmental awareness coupled with the recent changes in the oil prices triggered the necessity of focusing on effective management of energy systems. Global climate change has caused many people to consider ways of reducing greenhouse gases Renewable energy has become an essential feature in curtailing emission of Green House Gases, while meeting the demand for energy. This paper presents an innovation system framework for development and diffusion of renewable energy technologies. The framework is used to identify opportunities for small and medium enterprises in the renewable energy sector. A case study on a successful development, installation and implementation of solar thermal systems households in Calgary, Alberta, by an entrepreneurial firm, is also presented. (author)

  13. A review of computer tools for analysing the integration of renewable energy into various energy systems

    DEFF Research Database (Denmark)

    Connolly, D.; Lund, Henrik; Mathiesen, Brian Vad

    2010-01-01

    to integrating renewable energy, but instead the ‘ideal’ energy tool is highly dependent on the specific objectives that must be fulfilled. The typical applications for the 37 tools reviewed (from analysing single-building systems to national energy-systems), combined with numerous other factors......This paper includes a review of the different computer tools that can be used to analyse the integration of renewable energy. Initially 68 tools were considered, but 37 were included in the final analysis which was carried out in collaboration with the tool developers or recommended points...... of contact. The results in this paper provide the information necessary to identify a suitable energy tool for analysing the integration of renewable energy into various energy-systems under different objectives. It is evident from this paper that there is no energy tool that addresses all issues related...

  14. Renewable energy systems - the environmental impact approach. Paper no. IGEC-1-008

    International Nuclear Information System (INIS)

    Koroneos, C.

    2005-01-01

    High energy consumption and the world population increase will lead to a shrinking use of fossil fuels. The combustion of Fossil fuel leads to the increase of carbon dioxide concentration in the atmosphere which leads to the probable increase of global warming. Therefore, concerns about carbon dioxide emissions may discourage widespread dependence on fossil fuels and encourage the development and use of renewable energy systems employing a variety of technologies Renewable energy systems have themselves an environmental impact. Land use and material employed are two areas that may have an adverse impact to the positive environmental picture of the renewable energy systems. The objective of this paper is to analyze these impacts with the use of a very powerful tool, the Life Cycle Assessment. (author)

  15. Integrating Renewable Energy into the Transmission and Distribution System of the U. S. Virgin Islands

    Energy Technology Data Exchange (ETDEWEB)

    Burman, K.; Olis, D.; Gevorgian, V.; Warren, A.; Butt, R.; Lilienthal, P.; Glassmire, J.

    2011-09-01

    This report focuses on the economic and technical feasibility of integrating renewable energy technologies into the U.S. Virgin Islands transmission and distribution systems. The report includes three main areas of analysis: 1) the economics of deploying utility-scale renewable energy technologies on St. Thomas/St. John and St. Croix; 2) potential sites for installing roof- and ground-mount PV systems and wind turbines and the impact renewable generation will have on the electrical subtransmission and distribution infrastructure, and 3) the feasibility of a 100- to 200-megawatt power interconnection of the Puerto Rico Electric Power Authority (PREPA), Virgin Islands Water and Power Authority (WAPA), and British Virgin Islands (BVI) grids via a submarine cable system.

  16. Global Renewable Energy-Based Electricity Generation and Smart Grid System for Energy Security

    Science.gov (United States)

    Islam, M. A.; Hasanuzzaman, M.; Rahim, N. A.; Nahar, A.; Hosenuzzaman, M.

    2014-01-01

    Energy is an indispensable factor for the economic growth and development of a country. Energy consumption is rapidly increasing worldwide. To fulfill this energy demand, alternative energy sources and efficient utilization are being explored. Various sources of renewable energy and their efficient utilization are comprehensively reviewed and presented in this paper. Also the trend in research and development for the technological advancement of energy utilization and smart grid system for future energy security is presented. Results show that renewable energy resources are becoming more prevalent as more electricity generation becomes necessary and could provide half of the total energy demands by 2050. To satisfy the future energy demand, the smart grid system can be used as an efficient system for energy security. The smart grid also delivers significant environmental benefits by conservation and renewable generation integration. PMID:25243201

  17. Global renewable energy-based electricity generation and smart grid system for energy security.

    Science.gov (United States)

    Islam, M A; Hasanuzzaman, M; Rahim, N A; Nahar, A; Hosenuzzaman, M

    2014-01-01

    Energy is an indispensable factor for the economic growth and development of a country. Energy consumption is rapidly increasing worldwide. To fulfill this energy demand, alternative energy sources and efficient utilization are being explored. Various sources of renewable energy and their efficient utilization are comprehensively reviewed and presented in this paper. Also the trend in research and development for the technological advancement of energy utilization and smart grid system for future energy security is presented. Results show that renewable energy resources are becoming more prevalent as more electricity generation becomes necessary and could provide half of the total energy demands by 2050. To satisfy the future energy demand, the smart grid system can be used as an efficient system for energy security. The smart grid also delivers significant environmental benefits by conservation and renewable generation integration.

  18. Global Renewable Energy-Based Electricity Generation and Smart Grid System for Energy Security

    Directory of Open Access Journals (Sweden)

    M. A. Islam

    2014-01-01

    Full Text Available Energy is an indispensable factor for the economic growth and development of a country. Energy consumption is rapidly increasing worldwide. To fulfill this energy demand, alternative energy sources and efficient utilization are being explored. Various sources of renewable energy and their efficient utilization are comprehensively reviewed and presented in this paper. Also the trend in research and development for the technological advancement of energy utilization and smart grid system for future energy security is presented. Results show that renewable energy resources are becoming more prevalent as more electricity generation becomes necessary and could provide half of the total energy demands by 2050. To satisfy the future energy demand, the smart grid system can be used as an efficient system for energy security. The smart grid also delivers significant environmental benefits by conservation and renewable generation integration.

  19. UK innovation systems for new and renewable energy technologies: drivers, barriers and systems failures

    International Nuclear Information System (INIS)

    Foxon, T.J.; Gross, R.; Chase, A.; Howes, J.; Arnall, A.; Anderson, D.

    2005-01-01

    A better understanding of the systemic processes by which innovation occurs is useful, both conceptually and to inform policy-making in support of innovation in more sustainable technologies. This paper analyses current innovation systems in the UK for a range of new and renewable energy technologies, and generates policy recommendations for improving the effectiveness of these innovation systems. Although incentives are in place in the UK to encourage innovation in these technologies, system failures - or 'gaps' - are identified in moving technologies along the innovation chain, preventing their successful commercialisation. Sustained investment will be needed for these technologies to achieve their potential. It is argued that a stable and consistent policy framework is required to help create the conditions for this. In particular, such a framework should be aimed at improving risk/reward ratios for demonstration and pre-commercial stage technologies. This would enhance positive expectations, stimulate learning effects leading to cost reductions, and increase the likelihood of successful commercialisation

  20. Power system and market integration of renewable electricity

    Directory of Open Access Journals (Sweden)

    Erdmann Georg

    2017-01-01

    Full Text Available This paper addresses problems of power generation markets that arise under high shares of intermittent generation. After discussing the economic fundamentals of wind and photovoltaic investments, the paper introduces the concept of the “Merit order effect of renewables”. According to this concept electricity prices on wholesale power markets become smaller in periods during which large volumes of wind and photovoltaic generation is available and squeeze out relative expensive gas-fired power generation. The merit order effect of renewables has a couple of consequences. Among others it challenges the profitability of conventional power generation. If such generation capacities are still necessary, at least during a transitory period, a capacity mechanism may be put in place that generates an additional stream of income to the operators of conventional power generators. Another consequence of growing intermittent power generation is the need for concepts and technologies that deal with excess generation. Among these concepts are virtual and physical power storage capacities. In the last parts of the paper models are presented that are able to analyze these concepts from an economic point of view.

  1. Renewable Energy Use in Smallholder Farming Systems: A Case Study in Tafresh Township of Iran

    Directory of Open Access Journals (Sweden)

    Hossein Shabanali Fami

    2010-03-01

    Full Text Available This study was conducted to investigate use of renewable energy and materials in smallholder farming system of the Tafresh township of Iran. The population of the study consisted of 2,400 small farmers working in the smallholder farming systems of the area, in which 133 people were selected as sample using Cochran formula and simple random sampling technique. In order to gather the information, a questionnaire was developed for the study and validated by the judgment of the experts in agricultural development and extension. The reliability of the main scales of the questionnaire was examined by Cronbach Alpha coefficients, which ranged from 0.7 to 0.93, indicating the tool of study is reliable. The findings revealed that the majority of the respondents use renewable energy and materials directly in its traditional forms without enabling technologies, and they lack the access to renewable technologies to improve the efficiency of energy use. They preferred fossil energy for many activities due to its lower cost and ease of access. The overall conclusion is that there are potentials and capacities for using renewable energies and materials in the farming systems of the Tafresh township. The government has to support and encourage the adoption of renewable technologies and abandon fossil fuels wherever possible.

  2. A New Hybrid PLL for Interconnecting Renewable Energy Systems to the Grid

    DEFF Research Database (Denmark)

    Hadjidemetriou, Lenos; Kyriakides, Elias; Blaabjerg, Frede

    2013-01-01

    There is a need to develop new control strategies for interconnecting renewable energy systems (RESs) to the power grid due to the continuously increasing penetration of RES and, in particular, of wind power systems. The control strategies are typically based on a fast and accurate detection...

  3. A global renewable energy system: A modelling exercise in ETSAP/TIAM

    DEFF Research Database (Denmark)

    Føyn, Tullik Helene Ystanes; Karlsson, Kenneth Bernard; Balyk, Olexandr

    2011-01-01

    This paper aims to test the ETSAP2-TIAM global energy system model and to try out how far it can go towards a global 100% renewable energy system with the existing model database. This will show where limits in global resources are met and where limits in the data fed to the model until now are met...

  4. Representation of variable renewable energy sources in TIMER, an aggregated energy system simulation model

    NARCIS (Netherlands)

    de Boer, Harmen Sytze (H S.).; van Vuuren, Detlef (D P.).

    2017-01-01

    The power system is expected to play an important role in climate change mitigation. Variable renewable energy (VRE) sources, such as wind and solar power, are currently showing rapid growth rates in power systems worldwide, and could also be important in future mitigation strategies. It is

  5. Functional evolution and accumulation of technological innovation systems: the case of renewable energy in East Africa

    NARCIS (Netherlands)

    Tigabu, A.D.; Berkhout, F.G.H.; van Beukering, P.J.H.

    2015-01-01

    This paper compares the historical development of innovation systems related to biogas and improved cooking stove technologies in Rwanda and Kenya by applying the 'functions approach'. It argues that the accumulation of functions in these four renewable energy technological innovation systems (TISs)

  6. A Control Architecture to Coordinate Renewable Energy Sources and Energy Storage Systems in Islanded Microgrids

    DEFF Research Database (Denmark)

    Wu, Dan; Tang, Fen; Dragicevic, Tomislav

    2015-01-01

    Coordinated operation of microgrids requires that energy management system takes into account both the available power in renewable energy sources (RES) and storage capacity of energy storage systems (ESS). In this paper, a coordinated architecture of islanded AC microgrids with smooth switching...

  7. A Novel Coordinated Control of Renewable Energy Sources and Energy Storage System in Islanded Microgrid

    DEFF Research Database (Denmark)

    Gui, Yonghao; Li, Mingshen; Guerrero, Josep M.

    2018-01-01

    A novel coordinated control for energy storage system (ESS) and renewable energy source (RES) units is proposed in islanded AC microgrids without a phase-locked loop system. We use a proportional-resonant control technique for the ESS, which fixes the voltage and frequency of the microgrid...

  8. Nuclear-Renewable Hybrid System Economic Basis for Electricity, Fuel, and Hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Charles Forsberg; Steven Aumeier

    2014-04-01

    Concerns about climate change and altering the ocean chemistry are likely to limit the use of fossil fuels. That implies a transition to a low-carbon nuclear-renewable electricity grid. Historically variable electricity demand was met using fossil plants with low capital costs, high operating costs, and substantial greenhouse gas emissions. However, the most easily scalable very-low-emissions generating options, nuclear and non-dispatchable renewables (solar and wind), are capital-intensive technologies with low operating costs that should operate at full capacities to minimize costs. No combination of fully-utilized nuclear and renewables can meet the variable electricity demand. This implies large quantities of expensive excess generating capacity much of the time. In a free market this results in near-zero electricity prices at times of high nuclear renewables output and low electricity demand with electricity revenue collapse. Capital deployment efficiency—the economic benefit derived from energy systems capital investment at a societal level—strongly favors high utilization of these capital-intensive systems, especially if low-carbon nuclear renewables are to replace fossil fuels. Hybrid energy systems are one option for better utilization of these systems that consumes excess energy at times of low prices to make some useful product.The economic basis for development of hybrid energy systems is described for a low-carbon nuclear renewable world where much of the time there are massivequantities of excess energy available from the electric sector.Examples include (1) high-temperature electrolysis to generate hydrogen for non-fossil liquid fuels, direct use as a transport fuel, metal reduction, etc. and (2) biorefineries.Nuclear energy with its concentrated constant heat output may become the enabling technology for economically-viable low-carbon electricity grids because hybrid nuclear systems may provide an economic way to produce dispatachable variable

  9. Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells.

    Science.gov (United States)

    Sastry, K S R; Al-Muftah, M A; Li, Pu; Al-Kowari, M K; Wang, E; Ismail Chouchane, A; Kizhakayil, D; Kulik, G; Marincola, F M; Haoudi, A; Chouchane, L

    2014-12-01

    Emerging evidence suggests that the resistance of cancer stem cells (CSC) to many conventional therapies is one of the major limiting factors of cancer therapy efficacy. Identification of mechanisms responsible for survival and self-renewal of CSC will help design new therapeutic strategies that target and eliminate both differentiated cancer cells and CSC. Here we demonstrated the potential role of proapoptotic protein BAD in the biology of CSC in melanoma, prostate and breast cancers. We enriched CD44(+)/CD24(-) cells (CSC) by tumorosphere formation and purified this population by FACS. Both spheres and CSC exhibited increased potential for proliferation, migration, invasion, sphere formation, anchorage-independent growth, as well as upregulation of several stem cell-associated markers. We showed that the phosphorylation of BAD is essential for the survival of CSC. Conversely, ectopic expression of a phosphorylation-deficient mutant BAD induced apoptosis in CSC. This effect was enhanced by treatment with a BH3-mimetic, ABT-737. Both pharmacological agents that inhibit survival kinases and growth factors that are involved in drug resistance delivered their respective cytotoxic and protective effects by modulating the BAD phosphorylation in CSC. Furthermore, the frequency and self-renewal capacity of CSC was significantly reduced by knocking down the BAD expression. Consistent with our in vitro results, significant phosphorylation of BAD was found in CD44(+) CSC of 83% breast tumor specimens. In addition, we also identified a positive correlation between BAD expression and disease stage in prostate cancer, suggesting a role of BAD in tumor advancement. Our studies unveil the role of BAD in the survival and self-renewal of CSC and propose BAD not only as an attractive target for cancer therapy but also as a marker of tumor progression.

  10. Load management as a smart grid concept for sizing and designing of hybrid renewable energy systems

    Science.gov (United States)

    Eltamaly, Ali M.; Mohamed, Mohamed A.; Al-Saud, M. S.; Alolah, Abdulrahman I.

    2017-10-01

    Optimal sizing of hybrid renewable energy systems (HRES) to satisfy load requirements with the highest reliability and lowest cost is a crucial step in building HRESs to supply electricity to remote areas. Applying smart grid concepts such as load management can reduce the size of HRES components and reduce the cost of generated energy considerably. In this article, sizing of HRES is carried out by dividing the load into high- and low-priority parts. The proposed system is formed by a photovoltaic array, wind turbines, batteries, fuel cells and a diesel generator as a back-up energy source. A smart particle swarm optimization (PSO) algorithm using MATLAB is introduced to determine the optimal size of the HRES. The simulation was carried out with and without division of the load to compare these concepts. HOMER software was also used to simulate the proposed system without dividing the loads to verify the results obtained from the proposed PSO algorithm. The results show that the percentage of division of the load is inversely proportional to the cost of the generated energy.

  11. miR-99 regulates normal and malignant hematopoietic stem cell self-renewal.

    Science.gov (United States)

    Khalaj, Mona; Woolthuis, Carolien M; Hu, Wenhuo; Durham, Benjamin H; Chu, S Haihua; Qamar, Sarah; Armstrong, Scott A; Park, Christopher Y

    2017-07-21

    The microRNA-99 ( miR-99 ) family comprises a group of broadly conserved microRNAs that are highly expressed in hematopoietic stem cells (HSCs) and acute myeloid leukemia stem cells (LSCs) compared with their differentiated progeny. Herein, we show that miR-99 regulates self-renewal in both HSCs and LSCs. miR-99 maintains HSC long-term reconstitution activity by inhibiting differentiation and cell cycle entry. Moreover, miR-99 inhibition induced LSC differentiation and depletion in an MLL-AF9-driven mouse model of AML, leading to reduction in leukemia-initiating activity and improved survival in secondary transplants. Confirming miR-99 's role in established AML, miR-99 inhibition induced primary AML patient blasts to undergo differentiation. A forward genetic shRNA library screen revealed Hoxa1 as a critical mediator of miR-99 function in HSC maintenance, and this observation was independently confirmed in both HSCs and LSCs. Together, these studies demonstrate the importance of noncoding RNAs in the regulation of HSC and LSC function and identify miR-99 as a critical regulator of stem cell self-renewal. © 2017 Khalaj et al.

  12. Adult hematopoietic stem cells lacking Hif-1α self-renew normally

    Science.gov (United States)

    Vukovic, Milica; Sepulveda, Catarina; Subramani, Chithra; Guitart, Amélie V.; Mohr, Jasmine; Allen, Lewis; Panagopoulou, Theano I.; Paris, Jasmin; Lawson, Hannah; Villacreces, Arnaud; Armesilla-Diaz, Alejandro; Gezer, Deniz; Holyoake, Tessa L.; Ratcliffe, Peter J.

    2016-01-01

    The hematopoietic stem cell (HSC) pool is maintained under hypoxic conditions within the bone marrow microenvironment. Cellular responses to hypoxia are largely mediated by the hypoxia-inducible factors, Hif-1 and Hif-2. The oxygen-regulated α subunits of Hif-1 and Hif-2 (namely, Hif-1α and Hif-2α) form dimers with their stably expressed β subunits and control the transcription of downstream hypoxia-responsive genes to facilitate adaptation to low oxygen tension. An initial study concluded that Hif-1α is essential for HSC maintenance, whereby Hif-1α–deficient HSCs lost their ability to self-renew in serial transplantation assays. In another study, we demonstrated that Hif-2α is dispensable for cell-autonomous HSC maintenance, both under steady-state conditions and following transplantation. Given these unexpected findings, we set out to revisit the role of Hif-1α in cell-autonomous HSC functions. Here we demonstrate that inducible acute deletion of Hif-1α has no impact on HSC survival. Notably, unstressed HSCs lacking Hif-1α efficiently self-renew and sustain long-term multilineage hematopoiesis upon serial transplantation. Finally, Hif-1α–deficient HSCs recover normally after hematopoietic injury induced by serial administration of 5-fluorouracil. We therefore conclude that despite the hypoxic nature of the bone marrow microenvironment, Hif-1α is dispensable for cell-autonomous HSC maintenance. PMID:27060169

  13. Power electronic converter systems for direct drive renewable energy applications

    DEFF Research Database (Denmark)

    Chen, Zhe

    2013-01-01

    This chapter presents power electronic conversion systems for wind and marine energy generation applications, in particular, direct drive generator energy conversion systems. Various topologies are presented and system design optimization and reliability are briefly discussed....

  14. ER stress inducer tunicamycin suppresses the self-renewal of glioma-initiating cell partly through inhibiting Sox2 translation.

    Science.gov (United States)

    Xing, Yang; Ge, Yuqing; Liu, Chanjuan; Zhang, Xiaobiao; Jiang, Jianhai; Wei, Yuanyan

    2016-06-14

    Glioma-initiating cells possess tumor-initiating potential and are relatively resistant to conventional chemotherapy and irradiation. Therefore, their elimination is an essential factor for the development of efficient therapy. Here, we report that endoplasmic reticulum (ER) stress inducer tunicamycin inhibits glioma-initiating cell self-renewal as determined by neurosphere formation assay. Moreover, tunicamycin decreases the efficiency of glioma-initiating cell to initiate tumor formation. Although tunicamycin induces glioma-initiating cell apoptosis, apoptosis inhibitor z-VAD-fmk only partly abrogates the reduction in glioma-initiating cell self-renewal induced by tunicamycin. Indeed, tunicamycin reduces the expression of self-renewal regulator Sox2 at translation level. Overexpression of Sox2 obviously abrogates the reduction in glioma-initiating cell self-renewal induced by tunicamycin. Taken together, tunicamycin suppresses the self-renewal and tumorigenic potential of glioma-initiating cell partly through reducing Sox2 translation. This finding provides a cue to potential effective treatment of glioblastoma through controlling stem cells.

  15. Information Support of Optimal Control of Modes of Electric Systems with Renewable Energy Sources

    Directory of Open Access Journals (Sweden)

    Michalina Gryniewicz-Jaworska

    2017-12-01

    Full Text Available To provide necessary quality of electric energy and reliable supply and reduce environmental contamination as a result of energy units operation, renewable sources of energy (RSE, in particular solar electric stations (SES, wind electric stations (WES and small hydropower stations (SHES are intensively developed. The paper considers the conditions of optimality of renewable sources of energy (RSE functioning in electric systems, controllability of which is limited by the impact of non-stable weather conditions. The influence of control system information support on the efficiency of RSE usage is shown.

  16. Determination of Duty Cycle for Energy Storage Systems in a Renewables (Solar) Firming Application

    Energy Technology Data Exchange (ETDEWEB)

    Schoenwald, David A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Electric Power Systems Research Dept.; Ellison, James [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Electric Power Systems Research Dept.

    2016-04-01

    This report supplements the document, “Protocol for Uniformly Measuring and Expressing the Performance of Energy Storage Systems,” issued in a revised version in April 2016, which will include the renewables (solar) firming application for an energy storage system (ESS). This report provides the background and documentation associated with the determination of a duty cycle for an ESS operated in a renewables (solar) firming application for the purpose of measuring and expressing ESS performance in accordance with the ESS performance protocol.

  17. Post-disaster resilience of a 100% renewable energy system in Japan

    International Nuclear Information System (INIS)

    Esteban, Miguel; Portugal-Pereira, Joana

    2014-01-01

    Following the 2011 Fukushima nuclear disaster, Japan is having to re-design its energy policy. With the danger of nuclear power in an earthquake-prone country exposed, renewable energies are being seen as a potential alternative. An assessment of the feasibility of a 100% renewable energy electricity system in Japan by the year 2030 was shown to be able to achieve a higher level of electricity resilience. The assessment is based on a simulation of the hourly future electricity production based on wind and solar meteorological data, that can cope with the estimated future hourly electricity demand in Japan for the year 2030. Such as system would use pump-up storage and electric batteries to balance the daily fluctuations in supply and demand, though the most important challenge of the system would be providing sufficient electricity to meet the summer demand peak. These findings have import implications at the policy making level, as it shows that the Japanese electricity generation system is technically able to increase the share of renewables up to 100%, guaranteeing a stable and reliable supply. - Highlights: • Hourly simulation of a 100% renewable energy system in Japan. • Feasibility analysis of system reliability and risk of failure. • Use of car electric batteries to store electricity during night. • Analysis of policy implications to implement decentralized smart grid system

  18. The Integration of Renewable Energy Sources into Electric Power Distribution Systems, Vol. II Utility Case Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Zaininger, H.W.

    1994-01-01

    Electric utility distribution system impacts associated with the integration of renewable energy sources such as photovoltaics (PV) and wind turbines (WT) are considered in this project. The impacts are expected to vary from site to site according to the following characteristics: the local solar insolation and/or wind characteristics, renewable energy source penetration level, whether battery or other energy storage systems are applied, and local utility distribution design standards and planning practices. Small, distributed renewable energy sources are connected to the utility distribution system like other, similar kW- and MW-scale equipment and loads. Residential applications are expected to be connected to single-phase 120/240-V secondaries. Larger kW-scale applications may be connected to three+phase secondaries, and larger hundred-kW and y-scale applications, such as MW-scale windfarms, or PV plants, may be connected to electric utility primary systems via customer-owned primary and secondary collection systems. In any case, the installation of small, distributed renewable energy sources is expected to have a significant impact on local utility distribution primary and secondary system economics. Small, distributed renewable energy sources installed on utility distribution systems will also produce nonsite-specific utility generation system benefits such as energy and capacity displacement benefits, in addition to the local site-specific distribution system benefits. Although generation system benefits are not site-specific, they are utility-specific, and they vary significantly among utilities in different regions. In addition, transmission system benefits, environmental benefits and other benefits may apply. These benefits also vary significantly among utilities and regions. Seven utility case studies considering PV, WT, and battery storage were conducted to identify a range of potential renewable energy source distribution system applications. The

  19. Feasibility study and energy conversion analysis of stand-alone hybrid renewable energy system

    International Nuclear Information System (INIS)

    Baghdadi, Fazia; Mohammedi, Kamal; Diaf, Said; Behar, Omar

    2015-01-01

    Highlights: • Hybrid stand-alone wind–solar–fossil power system is analyzed. • Measurement data are used to evaluate system performance. • The proposed system can generate about 70% from renewables. • Such a hybrid plant is very promising for remote regions in Algeria. - Abstract: There is a great interest in the development of renewable power technologies in Algeria, and more particularly hybrid concept. The present paper has investigated the performance of hybrid PV–Wind–Diesel–Battery configuration based on hourly measurements of Adrar climate (southern Algeria). Data of global solar radiation, ambient temperature and wind speed for a period of one year have been used. Firstly, the proposed hybrid system has been optimized by means of HOMER software. The optimization process has been carried out taking into account renewable resources potential and energy demand; while maximizing renewable electricity use and fuel saving are the purpose. In the second step, a mathematical model has been developed to ensure efficient energy management on the basis of various operation strategies. The analysis has shown that renewable energy system (PV–Wind) is able to supply about 70% of the demand. Wind power has ranked first with 43% of the annual total electricity production followed by diesel generator (with 31%) while the remaining fraction is being to PV panels. In this context, 69% of the fossil fuel can be saved when using the proposed hybrid configuration instead of the diesel generators that are currently installed in most remote regions in Algeria. Such a concept is very promising to meet the focus of renewable energy program announced in 2011.

  20. Pretreated Landfill Gas Conversion Process via a Catalytic Membrane Reactor for Renewable Combined Fuel Cell-Power Generation

    Directory of Open Access Journals (Sweden)

    Zoe Ziaka

    2013-01-01

    Full Text Available A new landfill gas-based reforming catalytic processing system for the conversion of gaseous hydrocarbons, such as incoming methane to hydrogen and carbon oxide mixtures, is described and analyzed. The exit synthesis gas (syn-gas is fed to power effectively high-temperature fuel cells such as SOFC types for combined efficient electricity generation. The current research work is also referred on the description and design aspects of permreactors (permeable reformers carrying the same type of landfill gas-reforming reactions. Membrane reactors is a new technology that can be applied efficiently in such systems. Membrane reactors seem to perform better than the nonmembrane traditional reactors. The aim of this research includes turnkey system and process development for the landfill-based power generation and fuel cell industries. Also, a discussion of the efficient utilization of landfill and waste type resources for combined green-type/renewable power generation with increased processing capacity and efficiency via fuel cell systems is taking place. Moreover, pollution reduction is an additional design consideration in the current catalytic processors fuel cell cycles.

  1. Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma.

    Science.gov (United States)

    Shan, Juanjuan; Shen, Junjie; Liu, Limei; Xia, Feng; Xu, Chuan; Duan, Guangjie; Xu, Yanmin; Ma, Qinghua; Yang, Zhi; Zhang, Qianzhen; Ma, Leina; Liu, Jia; Xu, Senlin; Yan, Xiaochu; Bie, Ping; Cui, Youhong; Bian, Xiu-wu; Qian, Cheng

    2012-09-01

    Hepatocellular carcinoma (HCC) exhibits cellular heterogeneity and embryonic stem-cell-related genes are preferentially overexpressed in a fraction of cancer cells of poorly differentiated tumors. However, it is not known whether or how these cancer cells contribute to tumor initiation and progression. Here, our data showed that increased expression of pluripotency transcription factor Nanog in cancer cells correlates with a worse clinical outcome in HCC. Using the Nanog promoter as a reporter system, we could successfully isolate a small subpopulation of Nanog-positive cells. We demonstrate that Nanog-positive cells exhibited enhanced ability of self-renewal, clonogenicity, and initiation of tumors, which are consistent with crucial hallmarks in the definition of cancer stem cells (CSCs). Nanog(Pos) CSCs could differentiate into mature cancer cells in in vitro and in vivo conditions. In addition, we found that Nanog(Pos) CSCs exhibited resistance to therapeutic agents (e.g., sorafenib and cisplatin) and have a high capacity for tumor invasion and metastasis. Knock-down expression of Nanog in Nanog(Pos) CSCs could decrease self-renewal accompanied with decreased expression of stem-cell-related genes and increased expression of mature hepatocyte-related genes. Overexpression of Nanog in Nanog(Neg) cells could restore self-renewal. Furthermore, we found that insulin-like growth factor (IGF)2 and IGF receptor (IGF1R) were up-regulated in Nanog(Pos) CSCs. Knock-down expression of Nanog in Nanog(Pos) CSCs inhibited the expression of IGF1R, and overexpression of Nanog in Nanog(Neg) cells increased the expression of IGF1R. A specific inhibitor of IGF1R signaling could significantly inhibit self-renewal and Nanog expression, indicating that IGF1R signaling participated in Nanog-mediated self-renewal. These data indicate that Nanog could be a novel biomarker for CSCs in HCC, and that Nanog could play a crucial role in maintaining the self-renewal of CSCs through the IGF1R

  2. Strategies towards a 100% renewable energy system for Denmark in the Future Climate Project

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad

    2009-01-01

    energy system by the year 2050 are presented. Two short term transition target years in the process towards this goal are analysed for 2015 and 2030. The analyses reveal that implementing energy savings, renewable energy and more efficient conversion technologies can have positive socioeconomic effects......, create employment and potentially lead to large earnings on exports. If externalities such as health effects etc. are included, even more benefits can be expected. 100 per cent renewable energy systems will be technically possible in the future, and may even be economically beneficial compared......Greenhouse gas mitigation strategies are generally considered costly with world leaders often engaging in debate concerning the costs of mitigation and the distribution of these costs between different countries. In this paper, the analyses and results of the design of a 100 per cent renewable...

  3. Regional Energy Planning Tool for Renewable Integrated Low-Energy District Heating Systems

    DEFF Research Database (Denmark)

    Tol, Hakan; Dincer, Ibrahim; Svendsen, Svend

    2013-01-01

    Low-energy district heating systems, operating at low temperature of 55 °C as supply and 25°C as return, can be the energy solution as being the prevailing heating infrastructure in urban areas, considering future energy schemesaiming at increased exploitation of renewable energy sources together...... with low-energy houses in focus with intensified energy efficiency measures. Employing low-temperature operation allows the ease to exploit not only any type of heat source but also low-grade sources, i.e., renewable and industrial waste heat, which would otherwise be lost. In this chapter, a regional...... energy planning tool is described considered with various energy conversion systems based on renewable energy sources to be supplied to an integrated energy infrastructure involving a low-energy district heating, a district cooling, and an electricity grid. The developed tool is performed for two case...

  4. IEA-R1 renewed primary coolant piping system stress analysis

    International Nuclear Information System (INIS)

    Fainer, Gerson; Faloppa, Altair A.; Oliveira, Carlos A. de; Mattar Neto, Miguel

    2015-01-01

    A partial replacement of the IEA-R1 piping system was conducted in 2014. The aim of this work is to perform the stress analysis of the renewed primary piping system of the IEA-R1, taking into account the as built conditions and the pipe modifications. The nuclear research reactor IEA-R1 is a pool type reactor designed by Babcox-Willcox, which is operated by IPEN since 1957. The primary coolant system is responsible for removing the residual heat of the Reactor core. As a part of the life management, a regular inspection detected some degradation in the primary piping system. In consequence, part of the piping system was replaced. The partial renewing of the primary piping system did not imply in major piping layout modifications. However, the stress condition of the piping systems had to be reanalyzed. The structural stress analysis of the primary piping systems is now presented and the final results are discussed. (author)

  5. Investigation of Energy and Environmental Potentials of a Renewable Trigeneration System in a Residential Application

    Directory of Open Access Journals (Sweden)

    Eun-Chul Kang

    2016-09-01

    Full Text Available Micro polygeneration utilizing renewable energy is a suitable approach to reduce energy consumption and carbon emission by offering high-efficiency performance, offsetting the need for centrally-generated grid electricity and avoiding transmission/distribution losses associated with it. This paper investigates the energy and environmental potential of a renewable trigeneration system in a residential application under Incheon (Korea and Ottawa (Canada weather conditions. The trigeneration system consists of a ground-to-air heat exchanger (GAHX, photovoltaic thermal (PVT panels and an air-to-water heat pump (AWHP. The study is performed by simulations in TRNSYS (Version 17.02 environment. The performance of the trigeneration system is compared to a reference conventional system that utilizes a boiler for space and domestic hot water heating and a chiller for space cooling. Simulation results showed substantial annual primary energy savings from the renewable trigeneration system in comparison to the reference system—45% for Incheon and 42% for Ottawa. The CO2eq emission reduction from the renewable trigeneration system is also significant, standing at 43% for Incheon and 82% for Ottawa. Furthermore, trigeneration systems’ capability to generate electricity and thermal energy at the point of use is considered as an attractive option for inclusion in the future smart energy network applications.

  6. Integrated operation of electric vehicles and renewable generation in a smart distribution system

    International Nuclear Information System (INIS)

    Zakariazadeh, Alireza; Jadid, Shahram; Siano, Pierluigi

    2015-01-01

    Highlights: • The contribution of electric vehicles to provide the reserve capacity is analyzed. • Decentralized energy and reserve scheduling in a distribution system is presented. • The integrated operation of renewable generation and electric vehicles is proposed. - Abstract: Distribution system complexity is increasing mainly due to technological innovation, renewable Distributed Generation (DG) and responsive loads. This complexity makes difficult the monitoring, control and operation of distribution networks for Distribution System Operators (DSOs). In order to cope with this complexity, a novel method for the integrated operational planning of a distribution system is presented in this paper. The method introduces the figure of the aggregator, conceived as an intermediate agent between end-users and DSOs. In the proposed method, energy and reserve scheduling is carried out by both aggregators and DSO. Moreover, Electric Vehicles (EVs) are considered as responsive loads that can participate in ancillary service programs by providing reserve to the system. The efficiency of the proposed method is evaluated on an 84-bus distribution test system. Simulation results show that the integrated scheduling of EVs and renewable generators can mitigate the negative effects related to the uncertainty of renewable generation

  7. Qualitative modeling identifies IL-11 as a novel regulator in maintaining self-renewal in human pluripotent stem cells

    Directory of Open Access Journals (Sweden)

    Hedi ePeterson

    2013-10-01

    Full Text Available Pluripotency in human embryonic stem cells (hESCs and induced pluripotent stem cells (iPSCs is regulated by three transcription factors - OCT3/4, SOX2 and NANOG. To fully exploit the therapeutic potential of these cells it is essential to have a good mechanistic understanding of the maintenance of self-renewal and pluripotency. In this study, we demonstrate a powerful systems biology approach in which we first expand literature-based network encompassing the core regulators of pluripotency by assessing the behaviour of genes targeted by perturbation experiments. We focused our attention on highly regulated genes encoding cell surface and secreted proteins as these can be more easily manipulated by the use of inhibitors or recombinant proteins. Qualitative modeling based on combining boolean networks and in silico perturbation experiments were employed to identify novel pluripotency-regulating genes. We validated Interleukin-11 (IL-11 and demonstrate that this cytokine is a novel pluripotency-associated factor capable of supporting self-renewal in the absence of exogenously added bFGF in culture. To date, the various protocols for hESCs maintenance require supplementation with bFGF to activate the Activin/Nodal branch of the TGFβ signaling pathway. Additional evidence supporting our findings is that IL-11 belongs to the same protein family as LIF, which is known to be necessary for maintaining pluripotency in mouse but not in human ESCs. These cytokines operate through the same gp130 receptor which interacts with Janus kinases. Our finding might explain why mESCs are in a more naïve cell state compared to hESCs and how to convert primed hESCs back to the naïve state. Taken together, our integrative modeling approach has identified novel genes as putative candidates to be incorporated into the expansion of the current gene regulatory network responsible for inducing and maintaining pluripotency.

  8. Renewables cannot be stored economically on a well-run power system

    Science.gov (United States)

    Swift-Hook, Donald

    2017-11-01

    Economic storage on a power system must rely on arbitrage, buying electrical power when it is cheap and selling when it is dear. In practice, this means a store must buy power at night and sell it during the day. There is no solar power at night [by definition], so solar power cannot be stored economically on a well-run power system. Also renewables [and nuclear] are installed commercially to save fuel but fuel costs the same at night as it does during the day, so there is no arbitrage on fuel-saving to justify storage. Pumped water storage has always been widely used on power systems and is still the only method that is economic today, although many others have been tried, including fuels cells, compressed air and batteries. Devices for power correction and balancing [e.g. capacitor banks and batteries] may physically involve the storage of energy [just as a mobile phone does] but it is misleading to describe them as methods of power system storage, [just as it would be misleading to call a School bus a fuel transportation system, even though it does transport fuel]. When a power system has different sorts of plant generating - coal, gas, nuclear, wind etc - any power being put into storage is from the plant that would need to be switched off [because less power was needed] if storage ceased [e.g. because the store became full or failed]. On a well-run power system, that always has the highest fuel/running cost, but the wind blows free and has zero fuel/running cost, so wind is never [normally] stored unless there is no other plant on line i.e. wind power is the last to be stored.

  9. 90–100% renewable electricity for the South West Interconnected System of Western Australia

    International Nuclear Information System (INIS)

    Lu, Bin; Blakers, Andrew; Stocks, Matthew

    2017-01-01

    Rapidly increasing penetration of renewables, primarily wind and photovoltaics (PV), is causing a move away from fossil fuel in the Australian electric power industry. This study focuses on the South West Interconnected System in Western Australia. Several high (90% and 100%) renewables penetration scenarios have been modelled, comprising wind and PV supplemented with a small amount of biogas, and compared with a “like-for-like” fossil-fuel replacement scenario. Short-term off-river (closed cycle) pumped hydro energy storage (PHES) is utilised in some simulations as a large-scale conventional storage technology. The scenarios are examined by using a chronological dispatch model. An important feature of the modelling is that only technologies that have been already deployed on a large scale (>150 gigawatts) are utilised. This includes wind, PV and PHES. The modelling results demonstrate that 90–100% penetration by wind and PV electricity is compatible with a balanced grid. With the integration of off-river PHES, 90% renewables penetration is able to provide low-carbon electricity at competitive prices. Pumped hydro also facilitates a 100% renewables scenario which produces zero greenhouse gas emissions with attractive electricity prices. A sensitivity analysis shows the most important factors in the system cost are discount rate and wind turbine cost. - Highlights: • Short-term off-river pumped hydro energy storage (STORES). • 90–100% renewables for a large-scale self-contained power system. • PV and wind serves 80–90% of the total energy. • 90% renewables system costs $116 ($103)/MWh using 2016 (2030) prices.

  10. Electricity generation from renewable energy sources in Italy: the costs of the System Inefficiencies

    International Nuclear Information System (INIS)

    Bano, L.; Lorenzoni, A.

    2008-01-01

    The promotion of electricity from renewable energy sources (RES) is a high European Union (E U) priority for several reasons, including the security and diversification of energy supply, environmental protection and social and economic cohesion. The Eu Council's decision of 9 March 2007 points towards increasing renewable penetration to 20% of total primary energy supply by 2020 (binding target). There are both costs and benefits associated with the achievement of such an ambitious target. For renewable technologies, the industrial cost is often higher compared to other energy sources. however, due to learning curve effects and market diffusion, technology related costs are coming down considerably. In some cases, when the external costs are taken into account by the price system, renewable can now be close to competitive with fossil fuels. With particular reference to renewable electricity in Italy, its development is often hampered by burdensome and time consuming authorisation procedures with the consequence of a high mortality rate for the investments in the sector, leading to increased costs for the project management. Therefore, in these projects an important cost factor is the high cost of capital due to risk. The analysis of the various renewables' support mechanisms currently in place in the E U shows that some types of incentive have proven to be more efficient than others in reducing the risk perception of investors and financing institutions, therefore making projects less expensive by reducing the cost of capital (both debt and equity). Therefore the focus here is on the electricity generation costs of some renewable technologies and on the costs related to the additional risk perceived by investors/lenders in the sector. The authors estimate the additional cost of capital which investors pay when operating in a risky environment. Some policy indications are finally given to reduce the non-technology related costs for a faster and more efficient growth

  11. Cross-border versus cross-sector interconnectivity in renewable energy systems

    International Nuclear Information System (INIS)

    Thellufsen, Jakob Zinck; Lund, Henrik

    2017-01-01

    In the transition to renewable energy systems, fluctuating renewable energy, such as wind and solar power, plays a large and important role. This creates a challenge in terms of meeting demands, as the energy production fluctuates based on weather patterns. To utilise high amounts of fluctuating renewable energy, the energy system has to be more flexible in terms of decoupling demand and production. This paper investigates two potential ways to increase flexibility. The first is the interconnection between energy systems, for instance between two countries, labelled as cross-border interconnection, and the second is cross-sector interconnection, i.e., the integration between different parts of an energy system, for instance heat and electricity. This paper seeks to compare the types of interconnectivity and discuss to which extent they are mutually beneficial. To do this, the study investigates two energy systems that represent Northern and Southern Europe. Both systems go through three developmental steps that increase the cross-sector interconnectivity. At each developmental step an increasing level of transmission capacities is examined to identify the benefits of cross-border interconnectivity. The results show that while both measures increase the system utilisation of renewable energy and the system efficiency, the cross-sector interconnection gives the best system performance. To analyse the possible interaction between cross-sector and cross-border interconnectivity, two main aspects have to be clarified. The first part defines the approach and the second is the construction of the two archetypes. - Highlights: • A method to investigate system integration and system interconnection is suggested. • The implementation is investigated across a Northern and Southern energy system. • The study identifies benefits of system integration and system interconnection. • The performance of the energy system benefits most from system integration.

  12. Renewable Energy Certificate (REC) Tracking Systems: Costs & Verification Issues (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Heeter, J.

    2013-10-01

    This document provides information on REC tracking systems: how they are used in the voluntary REC market, a comparison of REC systems fees and information regarding how they treat environmental attributes.

  13. Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.

    Science.gov (United States)

    Yan, Xiao; Himburg, Heather A; Pohl, Katherine; Quarmyne, Mamle; Tran, Evelyn; Zhang, Yurun; Fang, Tiancheng; Kan, Jenny; Chao, Nelson J; Zhao, Liman; Doan, Phuong L; Chute, John P

    2016-11-01

    Imprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an imprinted gene, regulates hematopoietic stem cell (HSC) self-renewal and regeneration. Deletion of the maternal allele of Grb10 in mice (Grb10 m/+ mice) substantially increased HSC long-term repopulating capacity, as compared to that of Grb10 +/+ mice. After total body irradiation (TBI), Grb10 m/+ mice demonstrated accelerated HSC regeneration and hematopoietic reconstitution, as compared to Grb10 +/+ mice. Grb10-deficient HSCs displayed increased proliferation after competitive transplantation or TBI, commensurate with upregulation of CDK4 and Cyclin E. Furthermore, the enhanced HSC regeneration observed in Grb10-deficient mice was dependent on activation of the Akt/mTORC1 pathway. This study reveals a function for the imprinted gene Grb10 in regulating HSC self-renewal and regeneration and suggests that the inhibition of Grb10 can promote hematopoietic regeneration in vivo. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  14. Integration of supercapacitive storage in renewable energy system to compare the response of two level and five level inverter with RL type load

    Science.gov (United States)

    Jana, Suman; Biswas, Pabitra Kumar; Das, Upama

    2018-04-01

    The analytical and simulation-based study in this presented paper shows a comparative report between two level inverter and five-level inverter with the integration of Supercapacitive storage in Renewable Energy system. Sometime dependent numerical models are used to measure the voltage and current response of two level and five level inverter in MATLAB Simulink based environment. In this study supercapacitive sources, which are fed by solar cells are used as input sources to experiment the response of multilevel inverter with integration of su-percapacitor as a storage device of Renewable Energy System. The RL load is used to compute the time response in MATLABSimulink based environment. With the simulation results a comparative study has been made of two different level types of inverters. Two basic types of inverter are discussed in the study with reference to their electrical behavior. It is also simulated that multilevel inverter can convert stored energy within supercapacitor which is extracted from Renewable Energy System.

  15. Carbon Reduction Measures-Based LCA of Prefabricated Temporary Housing with Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    Ling Dong

    2018-03-01

    Full Text Available Temporary housing plays an important role in providing secure, hygienic, private, and comfortable shelter in the aftermath of disaster (such as flood, fire, earthquake, etc.. Additionally, temporary housing can also be used as a sustainable form of on-site residences for construction workers. While most of the building components used in temporary housing can be manufactured in a plant, prefabrication technology improves the production efficiency of temporary housing; furthermore, integrated renewable energy systems, for example, solar photovoltaic (PV system, offer benefits for temporary housing operations. In order to assess the environmental impacts of prefabricated temporary housing equipped with renewable energy systems, this study first divides the life cycle of temporary housing into six stages, and then establishes a life cycle assessment (LCA model for each stage. Furthermore, with the aim of reducing the environmental impacts, life cycle carbon reduction measures are proposed for each stage of temporary housing. The proposed methodology is demonstrated using a case study in China. Based on the proposed carbon reduction measures, the LCA of a prefabricated temporary housing case study building equipped with renewable energy systems indicates a carbon emissions intensity of 35.7 kg/m2·per year, as well as a reduction in material embodied emissions of 18%, assembly emissions of 17.5%, and operational emissions of 91.5%. This research proposes a carbon reduction-driven LCA of temporary housing and contributes to promoting sustainable development of prefabricated temporary housing equipped with renewable energy systems.

  16. Effect of wind energy system performance on optimal renewable energy model - an analysis

    International Nuclear Information System (INIS)

    Iniyan, S.; Jagadeesan, T.R.

    1998-01-01

    The Optimal Renewable Energy Model (OREM) has been developed to determine the optimum level of renewable energy sources utilisation in India for the year 2020-21. The model aims at minimising cost/efficiency ratio and determines the optimum allocation of different renewable energy sources for various end-uses. The extent of social acceptance level, potential limit, demand and reliability will decide the renewable energy distribution pattern and are hence used as constraints in the model. In this paper, the performance and reliability of wind energy system and its effects on OREM model has been analysed. The demonstration windfarm (4 MW) which is situated in Muppandal, a village in the southern part of India, has been selected for the study. The windfarm has 20 wind turbine machines of 200 KW capacity . The average technical availability, real availability and capacity factor have been analysed from 1991 to 1995 and they are found to be 94.1%, 76.4% and 25.5% respectively. The reliability factor of wind energy systems is found to be 0.5 at 10,000 hours. The OREM model is analysed considering the above said factors for wind energy system, solar energy system and biomass energy systems. The model selects wind energy for pumping end-use to an extent of 0.3153 x10 15 KJ. (Author)

  17. An Optimization Framework for Investment Evaluation of Complex Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    David Olave-Rojas

    2017-07-01

    Full Text Available Enhancing the role of renewable energies in existing power systems is one of the most crucial challenges that society faces today. However, the high variability of their generation potential and the temporal disparity between the demand and the generation potential represent technological and operational gaps that burden the massive incorporation of renewable sources into power systems. Energy storage technologies are an alternative to tackle this gap; nonetheless, their incorporation within large-scale power grids calls for decision-making tools that ensure an appropriate design and sizing of power systems that exploit the benefits of incorporating storage facilities along with renewable generation power. In this paper, we present an optimization framework for aiding the evaluation of the strategic design of complex renewable power systems. The developed tool relies on an optimization problem, the generation, transmission, storage energy location and sizing problem, which allows one to compute economically-attractive investment plans given by the location and sizing of generation and storage energy systems, along with the corresponding layout of transmission lines. Results on a real case study (located in the central region of Chile, characterized by carefully-curated data, show the potential of the developed tool for aiding long-term investment planning.

  18. Review of the Optimal Design on a Hybrid Renewable Energy System

    Directory of Open Access Journals (Sweden)

    Wu Yuan-Kang

    2016-01-01

    Full Text Available Hybrid renewable energy systems, combining various kinds of technologies, have shown relatively high capabilities to solve reliability problems and have reduced cost challenges. The use of hybrid electricity generation/storage technologies is reasonable to overcome related shortcomings. While the hybrid renewable energy system is attractive, its design, specifically the determination of the size of PV, wind, and diesel power generators and the size of energy storage system in each power station, is very challenging. Therefore, this paper will focus on the system planning and operation of hybrid generation systems, and several corresponding topics and papers by using intelligent computing methods will be reviewed. They include typical case studies, modeling and system simulation, control and management, reliability and economic studies, and optimal design on a reliable hybrid generation system.

  19. The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist.

    Science.gov (United States)

    Menchón, Cristina; Edel, Michael J; Izpisua Belmonte, Juan Carlos

    2011-05-01

    The continued turn over of human embryonic stem cells (hESC) while maintaining an undifferentiated state is dependent on the regulation of the cell cycle. Here we asked the question if a single cell cycle gene could regulate the self-renewal or pluripotency properties of hESC. We identified that the protein expression of the p27(Kip)¹ cell cycle inhibitor is low in hESC cells and increased with differentiation. By adopting a gain and loss of function strategy we forced or reduced its expression in undifferentiating conditions to define its functional role in self-renewal and pluripotency. Using undifferentiation conditions, overexpression of p27(Kip)¹ in hESC lead to a G₁phase arrest with an enlarged and flattened hESC morphology and consequent loss of self-renewal ability. Loss of p27(Kip)¹ caused an elongated/scatter cell-like phenotype involving up-regulation of Brachyury and Twist gene expression. We demonstrate the novel finding that p27(Kip)¹ protein occupies the Twist1 gene promoter and manipulation of p27(Kip)¹ by gain and loss of function is associated with Twist gene expression changes. These results define p27(Kip)¹ expression levels as critical for self-renewal and pluripotency in hESC and suggest a role for p27(Kip)¹ in controlling an epithelial to mesenchymal transition (EMT) in hESC.

  20. FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells.

    Science.gov (United States)

    Liu, Shuo; Zhang, Cun; Zhang, Kuo; Gao, Yuan; Wang, Zhaowei; Li, Xiaoju; Cheng, Guang; Wang, Shuning; Xue, Xiaochang; Li, Weina; Zhang, Wei; Zhang, Yingqi; Xing, Xianghui; Li, Meng; Hao, Qiang

    2017-07-04

    Colon cancer stem cell (cCSC) is considered as the seed cell of colon cancer initiation and metastasis. Cyclooxygenase-2 (COX2), a downstream target of NFκB, is found to be essential in promoting cancer stem cell renewal. However, how COX2 is dysregulated in cCSCs is largely unknown. In this study, we found that the expression of transcription factor FOXP3 was much lower in the spheroids than that in the parental tumor cells. Overexpression of FOXP3 significantly decreased the numbers of spheres, reduced the side population. Accordingly, FOXP3 expression decreased the tumor size and weight in the xenograft model. The tumor inhibitory effects of FOXP3 were rarely seen when COX2 was additionally knocked down. Mechanically, FOXP3 transcriptionally repressed COX2 expression via interacting with and thus inhibiting p65 activity on the putative NFκB response elements in COX2 promoter. Taken together, we here revealed possible involvement of FOXP3 in regulating cCSC self-renewal via tuning COX2 expression, and thus providing a new target for the eradication of colon cancer stem cells.

  1. Overview of U.S. programs for hydrogen from renewables

    International Nuclear Information System (INIS)

    Lewis, M.

    2007-01-01

    This paper discusses US program for hydrogen from renewable energy sources. Renewable energy sources include biomass, wind, solar, hydropower, geothermal and ocean waves. Although nuclear power is not considered renewable, a case can be made that it is, but requires recycling of spent fuel. The paper also discusses hydrogen production, storage and delivery. It discusses fuel cells, safety codes and standards and system analysis

  2. Expert Opinion Analysis on Renewable Hydrogen Storage Systems Potential in Europe

    Directory of Open Access Journals (Sweden)

    Davide Astiaso Garcia

    2016-11-01

    Full Text Available Among the several typologies of storage technologies, mainly on different physical principles (mechanical, electrical and chemical, hydrogen produced by power to gas (P2G from renewable energy sources complies with chemical storage principle and is based on the conversion of electrical energy into chemical energy by means of the electrolysis of water which does not produce any toxic or climate-relevant emission. This paper aims to pinpoint the potential uses of renewable hydrogen storage systems in Europe, analysing current and potential locations, regulatory framework, governments’ outlooks, economic issues, and available renewable energy amounts. The expert opinion survey, already used in many research articles on different topics including energy, has been selected as an effective method to produce realistic results. The obtained results highlight strategies and actions to optimize the storage of hydrogen produced by renewables to face varying electricity demand and generation-driven fluctuations reducing the negative effects of the increasing share of renewables in the energy mix of European Countries.

  3. Performance of different types of renewable power supply systems

    Energy Technology Data Exchange (ETDEWEB)

    Al-Motawakel, M K [Sana' a Univ. (Republic of Yemen). Dept. of Physics; Abu-El-Eizz, H M; Awwad, Z [Zagazig Univ. (EG). Dept. of Physics

    1991-10-01

    In this paper we investigate the performance of a hybrid Photovoltaic (PV)-Wind generator power supply system operating under good and fair insolation and wind regimes. The effectiveness of such a hybrid system is measured by the Relative Sizing Parameter (RSP), Money Saving Parameter (MSP), and the Overall Reliability Parameter (ORP). Under specified weather conditions and for a nominal load demand, the RSP relates the product of the PV-modules and storage batteries involved in sizing the PV-Wind hybrid system to those of a stand alone PV-system sized to meet the same load. The MSP reports the difference between the total costs of a stand-alone PV power supply system and a hybrid PV-Wind power supply system, both sized to meet the same load, as a percentage of the total costs involved in supplying the load with a stand-alone PV power supply system only. The ORP compares the yearly average of the daily excess energy (positive difference between generated and consumed energy) of the hybrid system to that of the stand-alone PV power system. Based on this strategy we were able to develop a number of design diagrams which can be used in judging the benefits of utilizing hybrid PW-Wind generators on both economic and energy reliability grounds. (author).

  4. Design for reliability in power electronics in renewable energy systems – status and future

    DEFF Research Database (Denmark)

    Wang, Huai; Blaabjerg, Frede; Ma, Ke

    2013-01-01

    Advances in power electronics enable efficient and flexible interconnection of renewable sources, loads and electric grids. While targets concerning efficiency of power converters are within reach, recent research endeavors to predict and improve their reliability to ensure high availability, low...... maintenance costs, and herefore, low Levelized-Cost-of-Energy (LCOE) of renewable energy systems. This paper presents the prior-art Design for Reliability (DFR) process for power converters and addresses the paradigm shift to Physics-of-Failure (PoF) approach and mission profile based analysis. Moreover...

  5. A knowledge-based approach to the design of integrated renewable energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Ramakumar, R.; Abouzahr, I. (Oklahoma State Univ., Stillwater, OK (United States). Engineering Energy Lab.); Ashenayi, K. (Dept. of Electrical Engineering, Univ. of Tulsa, Tulsa, OK (United States))

    1992-12-01

    Integrated Renewable Energy Systems (IRES) utilize two or more renewable energy resources and end-use technologies to supply a variety of energy needs, often in a stand-alone mode. A knowledge-based design approach that minimizes the total capital cost at a pre-selected reliability level is presented. The reliability level is quantified by the loss of power supply probability (LPSP). The procedure includes some resource-need matching based on economics, the quality of energy needed, and the characteristics of the resource. A detailed example is presented in this paper and discussed to illustrate the usefullness of the design approach.

  6. Power management of a hybrid renewable system for artificial islands: A case study

    International Nuclear Information System (INIS)

    Cozzolino, R.; Tribioli, L.; Bella, G.

    2016-01-01

    In this paper, a hybrid wind/solar/fuel cell power plant is designed and a possible power management strategy is proposed. In particular, wind and solar energy sources are used as primary power suppliers, while a pure-hydrogen-fueled fuel cell – with hydrogen produced by means of an electrolyzer recovering excess power – and a battery pack are employed to fulfill the power demand, when the power supplied by the renewable sources is not sufficient. The analysis is applied to a particular case study, i.e. the TUNeIT [TUNisia and ITaly] Project, that involves the realization of four artificial islands to connect Bon (Tunisia) and Pizzolato (Sicily), provided with electrical-power-demanding facilities for tourists. Components sizing has been performed with HOMER, where a load profile has been assumed in order to reproduce the possible power demand of one of these artificial islands, while Matlab/Simulink"® is used for simulations and power management strategy design. The obtained results demonstrate the possibility of realizing an almost self-sustaining renewable power plant, able to realize a good integration of different energy sources and power converters, with no negative effects on end-user satisfaction. The system would consist of a wind turbine of 1 MW and a photovoltaic array of 1.1 MW, acting as primary power sources and several backup systems, such as a 72-kWh battery, a 300-kW fuel cell and a 300-kW diesel engine to cope with power demand unmatches and/or failures. In order to verify the system performance under different situations, simulation studies have been carried out using practical load demand profiles and real weather data. Typical winter and summer day loads have been kept for simulations of a four-season scenario and results are provided to show the effectiveness of the proposed system. The major drawback encountered during the analysis is the low value of the utilization factors of both wind turbine and photovoltaic array, which are 10

  7. Techno-Economic Optimization of a Sustainable Energy System for a 100% Renewables Smart House

    DEFF Research Database (Denmark)

    Craciun, Vasile Simion; Blarke, Morten; Trifa, Viorel

    2012-01-01

    technical and economic challenges. One such challenge is the discontinuity, or intermittency, of generation, as most renewable energy resources depend on the climate, which is why their use requires complex design, planning and control optimization strategies. This paper presents a model and optimization...... for a sustainable energy system for a 100% renewables based Smart House (SH). We have devised and analysed an innovative high-efficiency approach to residential energy supply. The analysis involves detailed technical specifications and considerations for providing optimal supply of electricity, heating, cooling......The continuous increasing negative effects of fossil fuel consumption on society and the environment, opens a major interest into environmentally friendly alternatives to sustain the increasing demand for energy services. Despite the obvious advantages of renewable energy, it presents important...

  8. Stochastic stability of mechanical systems under renewal jump process parametric excitation

    DEFF Research Database (Denmark)

    Iwankiewicz, R.; Nielsen, Søren R.K.; Larsen, Jesper Winther

    2005-01-01

    A dynamic system under parametric excitation in the form of a non-Erlang renewal jump process is considered. The excitation is a random train of nonoverlapping rectangular pulses with equal, deterministic heights. The time intervals between two consecutive jumps up (or down), are the sum of two...

  9. Renewable Energy Water Pumping Systems Handbook; Period of Performance: April 1--September 1, 2001

    Energy Technology Data Exchange (ETDEWEB)

    Argaw, N.

    2004-07-01

    Water is one of the most basic necessities of rural development. This book provides valuable information on how renewable energy technologies can be used for irrigation, livestock watering, and domestic water supplies. This report emphasizes wind and solar energy resources, and hybrid water pumping systems.

  10. Renewable Energy Assessment of Bureau of Reclamation Land and Facilities Using Geographic Information Systems

    Energy Technology Data Exchange (ETDEWEB)

    Heimiller, D.; Haase, S.; Melius, J.

    2013-05-01

    This report summarizes results of geographic information system screening for solar and wind potential at select Bureau of Reclamation lands in the western United States. The study included both utility-scale and facility-scale potential. This study supplements information in the report titled Renewable Energy Assessment for the Bureau of Reclamation: Final Report.

  11. Model documentation Renewable Fuels Module of the National Energy Modeling System

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-01-01

    This report documents the objectives, analaytical approach and design of the National Energy Modeling System (NEMS) Renewable Fuels Module (RFM) as it relates to the production of the 1996 Annual Energy Outlook forecasts. The report catalogues and describes modeling assumptions, computational methodologies, data inputs, and parameter estimation techniques. A number of offline analyses used in lieu of RFM modeling components are also described.

  12. DECISION SUPPORT FOR RENEWAL OF WASTEWATER COLLECTIONS AND WATER DISTRIBUTION SYSTEMS

    Science.gov (United States)

    The decision of how to accomplish the renewal of existing wastewater collection and water distribution systems involves the evaluation of many criteria and parameters. These criteria must be evaluated thoroughly to determine the best way of rehabilitating or replacing these syste...

  13. Swiss pumped hydro storage potential for Germany's electricity system under high penetration of intermittent renewable energy

    NARCIS (Netherlands)

    van Meerwijk, Aagje J. H.; Benders, Reinerus; Davila-Martinez, Alejandro; Laugs, Gideon A. H.

    2016-01-01

    In order to cut greenhouse-gas emissions and increase energy security, the European Commission stimulates the deployment of intermittent renewable energy sources (IRES) towards 2050. In an electricity system with high shares of IRES implemented in the network, energy balancing like storage is needed

  14. Voltage Control Support and Coordination between Renewable Generation Plants in MV Distribution Systems

    DEFF Research Database (Denmark)

    Petersen, Lennart; Iov, Florin; Hansen, Anca Daniela

    2016-01-01

    This paper focusses on voltage control support and coordination between renewable generation plants in medium voltage distribution systems. An exemplary benchmark grid in Denmark, including a number of flexible ReGen plants providing voltage control functionality, is used as a base case. First...

  15. Analysis of Wastewater and Water System Renewal Decision-Making Tools and Approaches

    Science.gov (United States)

    In regards to the development of software for decision support for pipeline renewal, most of the attention to date has been paid to the development of asset management models which help an owner decide on which portions of a system to prioritize for needed actions. There has not ...

  16. Operating conditions of batteries in off-grid renewable energy systems

    DEFF Research Database (Denmark)

    Svoboda, V.; Wenzl, H.; Kaiser, R.

    2007-01-01

    for batteries. Categories are defined in such a way that batteries belonging to the same category are subjected to similar operating conditions and a similar combination of stress factors. The results provide a comprehensive overview of battery operating conditions in existing off-grid renewable energy systems...

  17. Cost-optimal electricity systems with increasing renewable energy penetration for islands across the globe

    NARCIS (Netherlands)

    Blok, K.; van Velzen, Leonore

    2018-01-01

    Cost-optimal electricity system configurations with increasing renewable energy penetration were determined in this article for six islands of different geographies, sizes and contexts, utilizing photovoltaic energy, wind energy, pumped hydro storage and battery storage. The results of the

  18. A Modelica based computational model for evaluating a renewable district heating system

    NARCIS (Netherlands)

    Soons, F.F.M.; Torrens Galdiz, J.I.; Hensen, J.L.M.; Schrevel, R.A.M. de

    2014-01-01

    District heating (DH) systems are considered a viable method for mitigating long-term climate change effects, through reduction of CO2 emissions, their high conversion efficiencies and their ability to be integrated with renewable energy sources (RES). The current evolution towards sustainable DH,

  19. Evaluating the Validity of Classroom Observations in the Head Start Designation Renewal System

    Science.gov (United States)

    Mashburn, Andrew J.

    2017-01-01

    Classroom observations are increasingly common in education policies as a means to assess the quality of teachers and/or education programs for purposes of making high-stakes decisions. This article considers one policy, the Head Start Designation Renewal System (DRS), which involves classroom observations to assess the quality of Head Start…

  20. Keeping an eye on reliability : The organizational requirements of future renewable energy systems

    NARCIS (Netherlands)

    Scholten, D.J.

    2012-01-01

    The reliable operation of energy infrastructures is more than just a technical matter. It is also dependent upon the organizational structure that enables and constrains entities in their management of operations. Yet this lesson seems forgotten in our planning of future renewable energy systems.

  1. Analysis and comparison of methods for the preparation of domestic hot water from district heating system, selected renewable and non-renewable sources in low-energy buildings

    Directory of Open Access Journals (Sweden)

    Knapik Maciej

    2018-01-01

    Full Text Available The article presents an economic analysis and comparison of selected (district heating, natural gas, heat pump with renewable energy sources methods for the preparation of domestic hot water in a building with low energy demand. In buildings of this type increased demand of energy for domestic hot water preparation in relation to the total energy demand can be observed. As a result, the proposed solutions allow to further lower energy demand by using the renewable energy sources. This article presents the results of numerical analysis and calculations performed mainly in MATLAB software, based on typical meteorological years. The results showed that system with heat pump and renewable energy sources Is comparable with district heating system.

  2. Analysis and comparison of methods for the preparation of domestic hot water from district heating system, selected renewable and non-renewable sources in low-energy buildings

    Science.gov (United States)

    Knapik, Maciej

    2018-02-01

    The article presents an economic analysis and comparison of selected (district heating, natural gas, heat pump with renewable energy sources) methods for the preparation of domestic hot water in a building with low energy demand. In buildings of this type increased demand of energy for domestic hot water preparation in relation to the total energy demand can be observed. As a result, the proposed solutions allow to further lower energy demand by using the renewable energy sources. This article presents the results of numerical analysis and calculations performed mainly in MATLAB software, based on typical meteorological years. The results showed that system with heat pump and renewable energy sources Is comparable with district heating system.

  3. Optimization of Domestic-Size Renewable Energy System Designs Suitable for Cold Climate Regions

    Science.gov (United States)

    Akpan, Itoro Etim; Sasaki, Masafumi; Endoh, Noboru

    Five different kinds of domestic-size renewable energy system configurations for very cold climate regions were investigated. From detailed numerical modeling and system simulations, it was found that the consumption of fuel oil for the auxiliary boiler in residential-type households can almost be eliminated with a renewable energy system that incorporates photovoltaic panel arrays for electricity generation and two storage tanks: a well-insulated electric water storage tank that services the hot water loads, and a compact boiler/geothermal heat pump tank for room heating during very cold seasons. A reduction of Greenhouse Gas Emissions (GHG) of about 28% was achieved for this system compared to an equivalent conventional system. The near elimination of the use of fuel oil in this system makes it very promising for very cold climate regions in terms of energy savings because the running cost is not so dependent on the unstable nature of global oil prices.

  4. Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

    NARCIS (Netherlands)

    Bruggeman, SWM; Valk-Lingbeek, ME; van der Stoop, PPM; Jacobs, JJL; Kieboom, K; Tanger, E; Hulsman, D; Leung, C; Arsenijevic, Y; Marino, S; van Lohuizen, M

    2005-01-01

    The Polycomb group (PcG) gene Bmi1 promotes cell proliferation and stem cell self-renewal by repressing the Ink4a/Arf locus. We used a genetic approach to investigate whether Ink4a or Arf is more critical for relaying Bmi1 function in lymphoid cells, neural progenitors, and neural stem cells. We

  5. Analysis of an Improved Solar-Powered Hydrogen Generation System for Sustained Renewable Energy Production

    Science.gov (United States)

    2017-12-01

    hydrogen gas by electrolysis. In LT Aviles’ design , distilled water was collected from the ambient air using Peltier dehumidifiers, manufactured by...Figure 13 shows the shelfing along with the entire system. Figure 13. Reconfigured Hydrogen Production Facility Because the system was designed for...POWERED HYDROGEN GENERATION SYSTEM FOR SUSTAINED RENEWABLE ENERGY PRODUCTION by Sen Feng Yu December 2017 Thesis Advisor: Garth V. Hobson Co

  6. Enhancement of human neural stem cell self-renewal in 3D hypoxic culture.

    Science.gov (United States)

    Ghourichaee, Sasan Sharee; Powell, Elizabeth M; Leach, Jennie B

    2017-05-01

    The pathology of neurological disorders is associated with the loss of neuronal and glial cells that results in functional impairments. Human neural stem cells (hNSCs), due to their self-renewing and multipotent characteristics, possess enormous tissue-specific regenerative potential. However, the efficacy of clinical applications is restricted due to the lack of standardized in vitro cell production methods with the capability of generating hNSC populations with well-defined cellular compositions. At any point, a population of hNSCs may include undifferentiated stem cells, intermediate and terminally differentiated progenies, and dead cells. Due to the plasticity of hNSCs, environmental cues play crucial roles in determining the cellular composition of hNSC cultures over time. Here, we investigated the independent and synergistic effect of three important environmental factors (i.e., culture dimensionality, oxygen concentration, and growth factors) on the survival, renewal potential, and differentiation of hNSCs. Our experimental design included two dimensional (2D) versus three dimensional (3D) cultures and normoxic (21% O 2 ) versus hypoxic (3% O 2 ) conditions in the presence and absence of epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2). Additionally, we discuss the feasibility of mathematical models that predict hNSC growth and differentiation under these culture conditions by adopting a negative feedback regulatory term. Our results indicate that the synergistic effect of culture dimensionality and hypoxic oxygen concentration in the presence of growth factors enhances the proliferation of viable, undifferentiated hNSCs. Moreover, the same synergistic effect in the absence of growth factors promotes the differentiation of hNSCs. Biotechnol. Bioeng. 2017;114: 1096-1106. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  7. Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.

    Directory of Open Access Journals (Sweden)

    Geqiang Li

    2010-02-01

    Full Text Available Grb2-associated binding (Gab adapter proteins play major roles in coordinating signaling downstream of hematopoietic cytokine receptors. In hematopoietic cells, Gab2 can modulate phosphatidylinositol-3 kinase and mitogen associated protein kinase activities and regulate the long-term multilineage competitive repopulating activity of hematopoietic stem cells (HSCs. Gab2 may also act in a linear pathway upstream or downstream of signal transducer and activator of transcription-5 (STAT5, a major positive regulator of HSC function. Therefore, we aimed to determine whether Gab2 and STAT5 function in hematopoiesis in a redundant or non-redundant manner.To do this we generated Gab2 mutant mice with heterozygous and homozygous deletions of STAT5. In heterozygous STAT5 mutant mice, deficiencies in HSC/multipotent progenitors were reflected by decreased long-term repopulating activity. This reduction in repopulation function was mirrored in the reduced growth response to early-acting cytokines from sorted double mutant c-Kit(+Lin(-Sca-1(+ (KLS cells. Importantly, in non-ablated newborn mice, the host steady-state engraftment ability was impaired by loss of Gab2 in heterozygous STAT5 mutant background. Fetal liver cells isolated from homozygous STAT5 mutant mice lacking Gab2 showed significant reduction in HSC number (KLS CD150(+CD48(-, reduced HSC survival, and dramatic loss of self-renewal potential as measured by serial transplantation.These data demonstrate new functions for Gab2 in hematopoiesis in a manner that is non-redundant with STAT5. Furthermore, important synergy between STAT5 and Gab2 was observed in HSC self-renewal, which might be exploited to optimize stem cell-based therapeutics.

  8. Empowering Variable Renewables - Options for Flexible Electricity Systems

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, Hugo [Renewable Energy Unit, International Energy Agency, Paris (France)

    2008-07-01

    A flexible electricity system is one that can respond reliably, and rapidly, to large fluctuations in supply and demand. Flexibility is already present in all power systems, in order to manage fluctuations in demand, and it is crucial for high performance and economic and reliable operation. This paper looks at measures to increase flexibility. but careful cost/benefit analysis is essential, and specific national and regional circumstances will influence the choice of option(s).

  9. Nuclear-Renewable Hybrid Energy Systems: 2016 Technology Development Program Plan

    International Nuclear Information System (INIS)

    Bragg-Sitton, Shannon M.; Boardman, Richard; Rabiti, Cristian; Suk Kim, Jong; McKellar, Michael; Sabharwall, Piyush; Chen, Jun; Cetiner, M. Sacit; Harrison, T. Jay; Qualls, A. Lou

    2016-01-01

    The United States is in the midst of an energy revolution, spurred by advancement of technology to produce unprecedented supplies of oil and natural gas. Simultaneously, there is an increasing concern for climate change attributed to greenhouse gas (GHG) emissions that, in large part, result from burning fossil fuels. An international consensus has concluded that the U.S. and other developed nations have an imperative to reduce GHG emissions to address these climate change concerns. The global desire to reduce GHG emissions has led to the development and deployment of clean energy resources and technologies, particularly renewable energy technologies, at a rapid rate. At the same time, each of the major energy sectors-the electric grid, industrial manufacturing, transportation, and the residential/commercial consumers- is increasingly becoming linked through information and communications technologies, advanced modeling and simulation, and controls. Coordination of clean energy generation technologies through integrated hybrid energy systems, as defined below, has the potential to further revolutionize energy services at the system level by coordinating the exchange of energy currency among the energy sectors in a manner that optimizes financial efficiency (including capital investments), maximizes thermodynamic efficiency (through best use of exergy, which is the potential to use the available energy in producing energy services), reduces environmental impacts when clean energy inputs are maximized, and provides resources for grid management. Rapid buildout of renewable technologies has been largely driven by local, state, and federal policies, such as renewable portfolio standards and production tax credits that incentivize investment in these generation sources. A foundational assumption within this program plan is that renewable technologies will continue to be major contributors to the future U.S. energy infrastructure. While increased use of clean renewable

  10. Nuclear-Renewable Hybrid Energy Systems: 2016 Technology Development Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    Bragg-Sitton, Shannon M. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Boardman, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Suk Kim, Jong [Idaho National Lab. (INL), Idaho Falls, ID (United States); McKellar, Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sabharwall, Piyush [Idaho National Lab. (INL), Idaho Falls, ID (United States); Chen, Jun [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cetiner, M. Sacit [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Harrison, T. Jay [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Qualls, A. Lou [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-03-01

    The United States is in the midst of an energy revolution, spurred by advancement of technology to produce unprecedented supplies of oil and natural gas. Simultaneously, there is an increasing concern for climate change attributed to greenhouse gas (GHG) emissions that, in large part, result from burning fossil fuels. An international consensus has concluded that the U.S. and other developed nations have an imperative to reduce GHG emissions to address these climate change concerns. The global desire to reduce GHG emissions has led to the development and deployment of clean energy resources and technologies, particularly renewable energy technologies, at a rapid rate. At the same time, each of the major energy sectors—the electric grid, industrial manufacturing, transportation, and the residential/commercial consumers— is increasingly becoming linked through information and communications technologies, advanced modeling and simulation, and controls. Coordination of clean energy generation technologies through integrated hybrid energy systems, as defined below, has the potential to further revolutionize energy services at the system level by coordinating the exchange of energy currency among the energy sectors in a manner that optimizes financial efficiency (including capital investments), maximizes thermodynamic efficiency (through best use of exergy, which is the potential to use the available energy in producing energy services), reduces environmental impacts when clean energy inputs are maximized, and provides resources for grid management. Rapid buildout of renewable technologies has been largely driven by local, state, and federal policies, such as renewable portfolio standards and production tax credits that incentivize investment in these generation sources. A foundational assumption within this program plan is that renewable technologies will continue to be major contributors to the future U.S. energy infrastructure. While increased use of clean

  11. The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche.

    Science.gov (United States)

    Issigonis, Melanie; Matunis, Erika

    2012-08-15

    Stem cells sustain tissue regeneration by their remarkable ability to replenish the stem cell pool and to generate differentiating progeny. Signals from local microenvironments, or niches, control stem cell behavior. In the Drosophila testis, a group of somatic support cells called the hub creates a stem cell niche by locally activating the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in two adjacent types of stem cells: germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Here, we find that ken and barbie (ken) is autonomously required for the self-renewal of CySCs but not GSCs. Furthermore, Ken misexpression in the CySC lineage induces the cell-autonomous self-renewal of somatic cells as well as the nonautonomous self-renewal of germ cells outside the niche. Thus, Ken, like Stat92E and its targets ZFH1 (Leatherman and Dinardo, 2008) and Chinmo (Flaherty et al., 2010), is necessary and sufficient for CySC renewal. However, ken is not a JAK-STAT target in the testis, but instead acts in parallel to Stat92E to ensure CySC self-renewal. Ken represses a subset of Stat92E targets in the embryo (Arbouzova et al., 2006) suggesting that Ken maintains CySCs by repressing differentiation factors. In support of this hypothesis, we find that the global JAK-STAT inhibitor Protein tyrosine phosphatase 61F (Ptp61F) is a JAK-STAT target in the testis that is repressed by Ken. Together, our work demonstrates that Ken has an important role in the inhibition of CySC differentiation. Studies of ken may inform our understanding of its vertebrate orthologue B-Cell Lymphoma 6 (BCL6) and how misregulation of this oncogene leads to human lymphomas. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment.

    Directory of Open Access Journals (Sweden)

    William B Hamilton

    Full Text Available Activation of the FGF-ERK pathway is necessary for naïve mouse embryonic stem (ES cells to exit self-renewal and commit to early differentiated lineages. Here we show that genetic ablation of Erk2, the predominant ERK isozyme expressed in ES cells, results in hyper-phosphorylation of ERK1, but an overall decrease in total ERK activity as judged by substrate phosphorylation and immediate-early gene (IEG induction. Normal induction of this subset of canonical ERK targets, as well as p90RSK phosphorylation, was rescued by transgenic expression of either ERK1 or ERK2 indicating a degree of functional redundancy. In contrast to previously published work, Erk2-null ES cells exhibited no detectable defect in lineage specification to any of the three germ layers when induced to differentiate in either embryoid bodies or in defined neural induction conditions. However, under self-renewing conditions Erk2-null ES cells express increased levels of the pluripotency-associated transcripts, Nanog and Tbx3, a decrease in Nanog-GFP heterogeneity, and exhibit enhanced self-renewal in colony forming assays. Transgenic add-back of ERK2 is capable of restoring normal pluripotent gene expression and self-renewal capacity. We show that ERK2 contributes to the destabilization of ES cell self-renewal by reducing expression of pluripotency genes, such as Nanog, but is not specifically required for the early stages of germ layer specification.

  13. A technical and economic analysis of one potential pathway to a 100% renewable energy system

    Directory of Open Access Journals (Sweden)

    David Connolly

    2014-02-01

    Full Text Available This paper outlines how an existing energy system can be transformed into a 100% renewable energy system. The transition is divided into a number of key stages which reflect key radical technological changes on the supply side of the energy system. Ireland is used as a case study,but in reality this reflects many typical energy systems today which use power plants for electricity, individual boilers for heat, and oil for transport. The seven stages analysed are 1 reference, 2 introduction of district heating, 3 installation of small and large-scale heat pumps,4 reducing grid regulation requirements, 5 adding flexible electricity demands and electric vehicles, 6 producing synthetic methanol/DME for transport, and finally 7 using synthetic gas to replace the remaining fossil fuels. For each stage, the technical and economic performance of the energy system is calculated. The results indicate that a 100% renewable energy system can provide the same end-user energy demands as today’s energy system and at the same price. Electricity will be the backbone of the energy system, but the flexibility in today’s electricity sector will be transferred from the supply side of the demand side in the future. Similarly, due to changes in the type of spending required in a 100% renewable energy system, this scenario will result in the creation of 100,000 additional jobs in Ireland compared to an energy system like today’s. These results are significant since they indicate that the transition to a 100% renewable energy system can begin today, without increasing the cost of energy in the short- or long-term, if the costs currently forecasted for 2050 become a reality.

  14. Storage and balancing synergies in a fully or highly renewable pan-European power system

    International Nuclear Information System (INIS)

    Rasmussen, Morten Grud; Andresen, Gorm Bruun; Greiner, Martin

    2012-01-01

    Through a parametric time-series analysis of 8 years of hourly data, we quantify the storage size and balancing energy needs for highly and fully renewable European power systems for different levels and mixes of wind and solar energy. By applying a dispatch strategy that minimizes the balancing energy needs for a given storage size, the interplay between storage and balancing is quantified, providing a hard upper limit on their synergy. An efficient but relatively small storage reduces balancing energy needs significantly due to its influence on intra-day mismatches. Furthermore, we show that combined with a low-efficiency hydrogen storage and a level of balancing equal to what is today provided by storage lakes, it is sufficient to meet the European electricity demand in a fully renewable power system where the average power generation from combined wind and solar exceeds the demand by only a few percent. - Highlights: ► We model a wind and solar based European power system with storage and balancing. ► We find that storage needs peaks when average renewable generation matches load. ► We find strong synergetic effects when combining storage and balancing. ► We study the effects of a storage capable of storing 6 h average use. ► We find a realisable fully renewable scenario based on wind, solar and hydro power.

  15. Transmission topologies for the integration of renewable power into the electricity systems of North Africa

    International Nuclear Information System (INIS)

    Brand, Bernhard

    2013-01-01

    A cost-minimizing electricity market model was used to explore optimized infrastructures for the integration of renewable energies in interconnected North African power systems until 2030. The results show that the five countries Morocco, Algeria, Tunisia, Libya and Egypt could together achieve significant economic benefits, reaching up to €3.4 billion, if they increase power system integration, build interconnectors and cooperate on joint utilization of their generation assets. Net electricity exports out of North Africa to Europe or Eastern Mediterranean regions, however, were not observed in the regime of integrated electricity markets until 2030, and could only be realized by much higher levels of renewable energy penetration than currently foreseen by North African governments. - Highlights: • Market model to optimize North Africa's generation and transmission infrastructures until 2030. • Simulations consider existing interconnectors, power plant inventories, as well as national renewable goals. • Savings of up to €3.4 billion can be realized by more cooperation and integrated system planning. • No electricity exports to Europe in a competitive market framework, except for very high renewable penetrations

  16. Transition towards Renewable Energy Production? Potential in Smallholder Agricultural Systems in West Bengal, India

    Directory of Open Access Journals (Sweden)

    Bastian Winkler

    2018-03-01

    Full Text Available Renewable energy (RE production promotes the efficient and sustainable utilization of natural resources at the local level. This study assessed smallholder farmers’ perceptions of RE production in two villages in West Bengal, India. The availability and potential of renewable resources and livelihood characteristics of smallholders were explored. Relevant factors for the selection of appropriate RE technologies were identified, based on the participatory, bottom-up Integrated Renewable Energy Potential Assessment. The research area has abundant solar resources and substantial amounts of organic residues and waste suitable for biodigestion. Important factors for RE technology selection, as stated by farmers, are: ease of daily activities, government support, and limited land requirements. Solar-photovoltaic (PV systems providing sufficient electricity for household use and irrigation are considered the most appropriate. Key informants focus on initial investment costs, government support, and reduced energy expenditure. They favor solar-PV systems for household electrification. Second choice was an integrated food and energy system that combines solar-PV for irrigation and vermicomposting of organic residues/wastes for fertilizer production. Smallholder famers’ motivation to produce and use RE is high. Their perspective should be integrated in the design of RE-supporting policies and related programs to utilize local natural resources effectively and promote the transition towards renewable energy.

  17. Sustainable application of renewable sources in water pumping systems: Optimized energy system configuration

    International Nuclear Information System (INIS)

    Ramos, J.S.; Ramos, H.M.

    2009-01-01

    Eighteen years ago, in Portugal, the expenses in a water supply system associated with energy consumption were quite low. However, with the successive crises of energy fuel and the increase of the energy tariff as well as the water demand, the energy consumption is becoming a larger and a more important part of the total budget of water supply pumping systems. Also, new governmental policies, essentially in developed countries, are trying to implement renewable energies. For these reasons, a case-study in Portugal of a water pumping system was analysed to operate connected to solar and wind energy sources. A stand-alone and a grid-connected systems were tested. The stand alone was compared with the cost of extending the national electric grid. In the grid-connected system two solutions were analysed, one with a water turbine and another without. To be able to implement a water turbine, a larger water pump was needed to pump the necessary water as for consumption as for energy production. For the case analysed the system without a water turbine proved to be more cost-effective because the energy tariff is not yet so competitive as well as the cost of water turbines

  18. Renewing the Future: Social Innovation Systems, Sector Shift, and Innoweave

    Directory of Open Access Journals (Sweden)

    Stephen Huddart

    2012-07-01

    Full Text Available Against a backdrop of various “occupy” movements signifying civic dissatisfaction with the social contract, and in an era of fiscal restraint affecting governments and communities in many parts of the world, we need new and more effective ways to address complex social challenges. While continuous innovation is commonly understood to be a source of growth, productivity improvement, and competitive advantage in the technology and manufacturing sectors, the author’s focus is on social innovation systems, designed to replace maladaptive institutions and obsolete policy frameworks with novel and disruptive means for improving outcomes on issues such as population health and climate change. This article proposes a definition of such systems, and examines how system-level tools including impact investing, open data platforms, and “change labs” are fostering collaboration among the private, public, and community sectors. We argue that a key priority at this time is to make these and other tools and processes for social innovation available to community organizations and their government and business partners everywhere, in a manner that allows for continuous cycles of implementation and learning. The author describes one such project currently being developed in Canada by Social Innovation Generation and other partners, called Innoweave. Innoweave is a technology-enabled social innovation system for sharing the tools and processes of social innovation with the community sector. The article concludes with a call for multi-sectoral participation in social innovation systems as an investment in society’s adaptive capacity and future wellbeing.

  19. Renewable energy.

    Science.gov (United States)

    Destouni, Georgia; Frank, Harry

    2010-01-01

    The Energy Committee of the Royal Swedish Academy of Sciences has in a series of projects gathered information and knowledge on renewable energy from various sources, both within and outside the academic world. In this article, we synthesize and summarize some of the main points on renewable energy from the various Energy Committee projects and the Committee's Energy 2050 symposium, regarding energy from water and wind, bioenergy, and solar energy. We further summarize the Energy Committee's scenario estimates of future renewable energy contributions to the global energy system, and other presentations given at the Energy 2050 symposium. In general, international coordination and investment in energy research and development is crucial to enable future reliance on renewable energy sources with minimal fossil fuel use.

  20. SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

    Directory of Open Access Journals (Sweden)

    Chi-Hsien Peng

    2010-06-01

    Full Text Available Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1, a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1. SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression.

  1. Towards fully renewable energy systems - Experience and trends in Denmark

    DEFF Research Database (Denmark)

    Pinson, Pierre; Mitridati, Lesia Marie-Jeanne Mariane; Ordoudis, Christos

    2017-01-01

    .g., wind and solar. Denmark is a country that invested early in wind energy, rapidly proposing very ambitious goals for the future of its energy system and global energy usage. While the case of Denmark is specific due to its limited size and good interconnections, there may still be a lot to learn from...

  2. The role of Photovoltaics towards 100% Renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; David, Andrei; Petersen, Silas

    builds on a literature review of the global and Danish trends in capacity, costs and types of support schemes, but also develops a GIS and energy system analysis supported by a set of economic calculations to inquire on the recommended pathway for the future investments in photovoltaics in Denmark...

  3. Markov Renewal Methods in Restart Problems in Complex Systems

    DEFF Research Database (Denmark)

    Asmussen, Søren; Lipsky, Lester; Thompson, Stephen

    A task with ideal execution time L such as the execution of a computer program or the transmission of a file on a data link may fail, and the task then needs to be restarted. The task is handled by a complex system with features similar to the ones in classical reliability: failures may...

  4. mir-300 promotes self-renewal and inhibits the differentiation of glioma stem-like cells

    KAUST Repository

    Zhang, Daming

    2014-01-28

    MicroRNAs (miRNAs) are small noncoding RNAs that have been critically implicated in several human cancers. miRNAs are thought to participate in various biological processes, including proliferation, cell cycle, apoptosis, and even the regulation of the stemness properties of cancer stem cells. In this study, we explore the potential role of miR-300 in glioma stem-like cells (GSLCs). We isolated GSLCs from glioma biopsy specimens and identified the stemness properties of the cells through neurosphere formation assays, multilineage differentiation ability analysis, and immunofluorescence analysis of glioma stem cell markers. We found that miR-300 is commonly upregulated in glioma tissues, and the expression of miR-300 was higher in GSLCs. The results of functional experiments demonstrated that miR-300 can enhance the self-renewal of GSLCs and reduce differentiation toward both astrocyte and neural fates. In addition, LZTS2 is a direct target of miR-300. In conclusion, our results demonstrate the critical role of miR-300 in GSLCs and its functions in LZTS2 inhibition and describe a new approach for the molecular regulation of tumor stem cells. © 2014 Springer Science+Business Media.

  5. Orphan nuclear receptor TLX activates Wnt/β-catenin signalling to stimulate neural stem cell proliferation and self-renewal

    Science.gov (United States)

    Qu, Qiuhao; Sun, Guoqiang; Li, Wenwu; Yang, Su; Ye, Peng; Zhao, Chunnian; Yu, Ruth T.; Gage, Fred H.; Evans, Ronald M.; Shi, Yanhong

    2010-01-01

    The nuclear receptor TLX (also known as NR2E1) is essential for adult neural stem cell self-renewal; however, the molecular mechanisms involved remain elusive. Here we show that TLX activates the canonical Wnt/β-catenin pathway in adult mouse neural stem cells. Furthermore, we demonstrate that Wnt/β-catenin signalling is important in the proliferation and self-renewal of adult neural stem cells in the presence of epidermal growth factor and fibroblast growth factor. Wnt7a and active β-catenin promote neural stem cell self-renewal, whereas the deletion of Wnt7a or the lentiviral transduction of axin, a β-catenin inhibitor, led to decreased cell proliferation in adult neurogenic areas. Lentiviral transduction of active β-catenin led to increased numbers of type B neural stem cells in the subventricular zone of adult brains, whereas deletion of Wnt7a or TLX resulted in decreased numbers of neural stem cells retaining bromodeoxyuridine label in the adult brain. Both Wnt7a and active β-catenin significantly rescued a TLX (also known as Nr2e1) short interfering RNA-induced deficiency in neural stem cell proliferation. Lentiviral transduction of an active β-catenin increased cell proliferation in neurogenic areas of TLX-null adult brains markedly. These results strongly support the hypothesis that TLX acts through the Wnt/β-catenin pathway to regulate neural stem cell proliferation and self-renewal. Moreover, this study suggests that neural stem cells can promote their own self-renewal by secreting signalling molecules that act in an autocrine/paracrine mode. PMID:20010817

  6. Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal.

    Science.gov (United States)

    Qu, Qiuhao; Sun, Guoqiang; Li, Wenwu; Yang, Su; Ye, Peng; Zhao, Chunnian; Yu, Ruth T; Gage, Fred H; Evans, Ronald M; Shi, Yanhong

    2010-01-01

    The nuclear receptor TLX (also known as NR2E1) is essential for adult neural stem cell self-renewal; however, the molecular mechanisms involved remain elusive. Here we show that TLX activates the canonical Wnt/beta-catenin pathway in adult mouse neural stem cells. Furthermore, we demonstrate that Wnt/beta-catenin signalling is important in the proliferation and self-renewal of adult neural stem cells in the presence of epidermal growth factor and fibroblast growth factor. Wnt7a and active beta-catenin promote neural stem cell self-renewal, whereas the deletion of Wnt7a or the lentiviral transduction of axin, a beta-catenin inhibitor, led to decreased cell proliferation in adult neurogenic areas. Lentiviral transduction of active beta-catenin led to increased numbers of type B neural stem cells in the subventricular zone of adult brains, whereas deletion of Wnt7a or TLX resulted in decreased numbers of neural stem cells retaining bromodeoxyuridine label in the adult brain. Both Wnt7a and active beta-catenin significantly rescued a TLX (also known as Nr2e1) short interfering RNA-induced deficiency in neural stem cell proliferation. Lentiviral transduction of an active beta-catenin increased cell proliferation in neurogenic areas of TLX-null adult brains markedly. These results strongly support the hypothesis that TLX acts through the Wnt/beta-catenin pathway to regulate neural stem cell proliferation and self-renewal. Moreover, this study suggests that neural stem cells can promote their own self-renewal by secreting signalling molecules that act in an autocrine/paracrine mode.

  7. Differential effects on cell motility, embryonic stem cell self-renewal and senescence by diverse Src kinase family inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Tamm, Christoffer, E-mail: christoffer.tamm@imbim.uu.se; Galito, Sara Pijuan, E-mail: sara.pijuan@imbim.uu.se; Anneren, Cecilia, E-mail: cecilia.anneren@imbim.uu.se

    2012-02-15

    The Src family of non-receptor tyrosine kinases (SFKs) has been shown to play an intricate role in embryonic stem (ES) cell maintenance. In the present study we have focused on the underlying molecular mechanisms responsible for the vastly different effects induced by various commonly used SFK inhibitors. We show that several diverse cell types, including fibroblasts completely lacking SFKs, cannot undergo mitosis in response to SU6656 and that this is caused by an unselective inhibition of Aurora kinases. In contrast, PP2 and PD173952 block motility immediately upon exposure and forces cells to grow in dense colonies. The subsequent halt in proliferation of fibroblast and epithelial cells in the center of the colonies approximately 24 h post-treatment appears to be caused by cell-to-cell contact inhibition rather than a direct effect of SFK kinase inhibition. Interestingly, in addition to generating more homogenous and dense ES cell cultures, without any diverse effect on proliferation, PP2 and PD173652 also promote ES cell self-renewal by reducing the small amount of spontaneous differentiation typically observed under standard ES cell culture conditions. These effects could not be mirrored by the use of Gleevec, a potent inhibitor of c-Abl and PDGFR kinases that are also inhibited by PP2. -- Highlights: Black-Right-Pointing-Pointer SFK inhibitor SU6656 induces senescence in mouse ES cells. Black-Right-Pointing-Pointer SU6656 inhibits mitosis in a SFK-independent manner via cross-selectivity for Aurora kinases. Black-Right-Pointing-Pointer SFK inhibitor PP2 impairs cell motility in various cell lines, including mouse ES cells. Black-Right-Pointing-Pointer Ensuing impeded motility, PP2 inhibits proliferation of various cells lines except for mouse ES cells. Black-Right-Pointing-Pointer SFK inhibitors PP2 and PD173952 impede spontaneous differentiation in standard mouse ES culture maintenance.

  8. Differential effects on cell motility, embryonic stem cell self-renewal and senescence by diverse Src kinase family inhibitors

    International Nuclear Information System (INIS)

    Tamm, Christoffer; Galitó, Sara Pijuan; Annerén, Cecilia

    2012-01-01

    The Src family of non-receptor tyrosine kinases (SFKs) has been shown to play an intricate role in embryonic stem (ES) cell maintenance. In the present study we have focused on the underlying molecular mechanisms responsible for the vastly different effects induced by various commonly used SFK inhibitors. We show that several diverse cell types, including fibroblasts completely lacking SFKs, cannot undergo mitosis in response to SU6656 and that this is caused by an unselective inhibition of Aurora kinases. In contrast, PP2 and PD173952 block motility immediately upon exposure and forces cells to grow in dense colonies. The subsequent halt in proliferation of fibroblast and epithelial cells in the center of the colonies approximately 24 h post-treatment appears to be caused by cell-to-cell contact inhibition rather than a direct effect of SFK kinase inhibition. Interestingly, in addition to generating more homogenous and dense ES cell cultures, without any diverse effect on proliferation, PP2 and PD173652 also promote ES cell self-renewal by reducing the small amount of spontaneous differentiation typically observed under standard ES cell culture conditions. These effects could not be mirrored by the use of Gleevec, a potent inhibitor of c-Abl and PDGFR kinases that are also inhibited by PP2. -- Highlights: ► SFK inhibitor SU6656 induces senescence in mouse ES cells. ► SU6656 inhibits mitosis in a SFK-independent manner via cross-selectivity for Aurora kinases. ► SFK inhibitor PP2 impairs cell motility in various cell lines, including mouse ES cells. ► Ensuing impeded motility, PP2 inhibits proliferation of various cells lines except for mouse ES cells. ► SFK inhibitors PP2 and PD173952 impede spontaneous differentiation in standard mouse ES culture maintenance.

  9. Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

    Science.gov (United States)

    Kobayashi, Hideki; Butler, Jason M.; O'Donnell, Rebekah; Kobayashi, Mariko; Ding, Bi-Sen; Bonner, Bryant; Chiu, Vi K.; Nolan, Daniel J.; Shido, Koji; Benjamin, Laura; Rafii, Shahin

    2010-01-01

    Endothelial cells establish an instructive vascular niche that reconstitutes haematopoietic stem and progenitor cells (HSPCs) through release of specific paracrine growth factors, known as angiocrine factors. However, the mechanism by which endothelial cells balance the rate of proliferation and lineage-specific differentiation of HSPCs is unknown. Here, we demonstrate that Akt activation in endothelial cells, through recruitment of mTOR, but not the FoxO pathway, upregulates specific angiocrine factors that support expansion of CD34−Flt3− KLS HSPCs with long-term haematopoietic stem cell (LT-HSC) repopulation capacity. Conversely, co-activation of Akt-stimulated endothelial cells with p42/44 MAPK shifts the balance towards maintenance and differentiation of the HSPCs. Selective activation of Akt1 in the endothelial cells of adult mice increased the number of colony forming units in the spleen and CD34−Flt3− KLS HSPCs with LT-HSC activity in the bone marrow, accelerating haematopoietic recovery. Therefore, the activation state of endothelial cells modulates reconstitution of HSPCs through the upregulation of angiocrine factors, with Akt–mTOR-activated endothelial cells supporting the self-renewal of LT-HSCs and expansion of HSPCs, whereas MAPK co-activation favours maintenance and lineage-specific differentiation of HSPCs. PMID:20972423

  10. Dispatchable Renewable Energy Model for Microgrid Power System

    Energy Technology Data Exchange (ETDEWEB)

    Chiou, Fred; Gentle, Jake P.; McJunkin, Timothy R.

    2017-04-01

    Over the years, many research projects have been performed and focused on finding out the effective ways to balance the power demands and supply on the utility grid. The causes of the imbalance could be the increasing demands from the end users, the loss of power generation (generators down), faults on the transmission lines, power tripped due to overload, and weather conditions, etc. An efficient Load Frequency Control (LFC) can assure the desired electricity quality provided to the residential, commercial and industrial end users. A simulation model is built in this project to investigate the contribution of the modeling of dispatchable energy such as solar energy, wind power, hydro power and energy storage to the balance of the microgrid power system. An analysis of simplified feedback control system with proportional, integral, and derivative (PID) controller was performed. The purpose of this research is to investigate a simulation model that achieves certain degree of the resilient control for the microgrid.

  11. In-situ rehabilitation cleans, lines, and renews pipe systems

    International Nuclear Information System (INIS)

    Munden, B.A.

    1990-01-01

    This article discusses how, in the past five years, developments in coating and lining material technology have found their way into pipe line application and have yielded successful results. The thick film, high solids material often used to repair tanks, vessels and offshore structures has now been adapted for existing pipe lines. One of the most promising of these systems in successful service is an epoxy, high solids (95%) material originally developed for nuclear service as a lining for reactor containment vessels

  12. Power Take-off System for Marine Renewable Devices, CRADA Number CRD-14-566

    Energy Technology Data Exchange (ETDEWEB)

    Muljadi, Eduard [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-13

    Ocean Renewable Power Company (ORPC) proposes a project to develop and test innovative second-generation power take-off (PTO) components for the U.S. Department of Energy's 2013 FOA: Marine and Hydrokinetic System Performance Advancement, Topic Area 2 (Project). Innovative PTO components will include new and improved designs for bearings, couplings and a subsea electrical generator. Specific project objectives include the following: (1) Develop components for an advanced PTO suitable for MHK devices; (2) Bench test these components; (3) Assess the component and system performance benefits; (4) Perform a system integration study to integrate these components into an ORPC hydrokinetic turbine. National Renewable Energy Laboratory (NREL) will participate on the ORPC lead team to review design of the generator and will provide guidance on the design. Based on inputs from the project team, NREL will also provide an economic analysis of the impacts of the proposed system performance advancements.

  13. AGING MANAGMENT OF REACTOR COOLANT SYSTEM MECHANICAL COMPONENTS FOR LICENSE RENEWAL

    International Nuclear Information System (INIS)

    SUBUDHI, M.; MORANTE, R.; LEE, A.D.

    2002-01-01

    The reactor coolant system (RCS) mechanical components that require an aging management review for license renewal include the primary loop piping and associated connections to other support systems, reactor vessel, reactor vessel internals, pressurizer. steam generators, reactor coolant pumps, and all other inter-connected piping, pipe fittings, valves, and bolting. All major RCS components are located inside the reactor building. Based on the evaluation findings of recently submitted license renewal applications for pressurized water reactors, this paper presents the plant programs and/or activities proposed by the applicants to manage the effects of aging. These programs and/or activities provide reasonable assurance that the intended function(s) of these mechanical components will be maintained for the period of extended operation. The license renewal application includes identification of RCS subcomponents that are within the scope of license renewal and are vulnerable to age-related degradation when exposed to environmental and operational conditions. determination of the effects of aging on their intended safety functions. and implementation of the aging management programs and/or activities including both current and new programs. Industry-wide operating experience, including generic communication by the NRC, is part of the aging management review for the RCS components. In addition, this paper discusses time-limited aging analyses associated with neutron embrittlement of the reactor vessel beltline region and thermal fatigue

  14. Translating EU renewable energy policy for insular energy systems: Reunion Island's quest for energy autonomy

    Directory of Open Access Journals (Sweden)

    Matthew Sawatzky

    2017-12-01

    Full Text Available Recognition of the negative impacts of climate change has led to agreement on the need to decarbonise energy systems through the employment of renewable energy. With many national and transnational policies in place, the options available to insular energy systems (IES differ from those of interconnected areas due to fragility in their production and distribution networks. Based on the concepts of policy mobility and translation, this study examines the interplay of EU renewable energy policy and insular governance processes aimed at achieving energy autonomy through renewable energy development. Reunion Island, a French Overseas Department and Region, is used as a case study to examine local energy governance processes, aspects that shape regional translation of national and EU policy, and the potential effects that create structures and pathways of energy transition. The study shows that Reunion Island’s regional Energy Governance Committee has significant application potential as a governance tool in other IES and small islands within the EU, but that renewable energy development is restricted due to national policy measures and path dependent governance structural constraints.

  15. Performance Analyses of Renewable and Fuel Power Supply Systems for Different Base Station Sites

    Directory of Open Access Journals (Sweden)

    Josip Lorincz

    2014-11-01

    Full Text Available Base station sites (BSSs powered with renewable energy sources have gained the attention of cellular operators during the last few years. This is because such “green” BSSs impose significant reductions in the operational expenditures (OPEX of telecom operators due to the possibility of on-site renewable energy harvesting. In this paper, the green BSSs power supply system parameters detected through remote and centralized real time sensing are presented. An implemented sensing system based on a wireless sensor network enables reliable collection and post-processing analyses of many parameters, such as: total charging/discharging current of power supply system, battery voltage and temperature, wind speed, etc. As an example, yearly sensing results for three different BSS configurations powered by solar and/or wind energy are discussed in terms of renewable energy supply (RES system performance. In the case of powering those BSS with standalone systems based on a fuel generator, the fuel consumption models expressing interdependence among the generator load and fuel consumption are proposed. This has allowed energy-efficiency comparison of the fuel powered and RES systems, which is presented in terms of the OPEX and carbon dioxide (CO2 reductions. Additionally, approaches based on different BSS air-conditioning systems and the on/off regulation of a daily fuel generator activity are proposed and validated in terms of energy and capital expenditure (CAPEX savings.

  16. Technical evaluation of two 6-kW mono-Si photovoltaic systems at the National Renewable Energy Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Dyk, E.E. van; Strand, T.; Hansen, R. [National Renewable Energy Lab., Golden, CO (United States)

    1996-05-01

    This paper presents an analysis of performance data on the two 6-kW{sub ac} grid-connected photovoltaic systems at the National Renewable Energy Laboratory (NREL). The performance parameters analyzed include dc and ac power, aperture efficiency, energy, capacity factor and performance index which are compared to plane-of-array irradiance, ambient temperature, and back-of-module temperature as a function of time, either daily or monthly. Power ratings of the systems were also obtained for data corresponding to different test conditions. This study has shown, in addition to expected seasonal trends, that system monitoring is a valuable tool in assessing performance and detecting faulty equipment. In addition, methods applied for this study may be used to evaluate and compare systems employing different cell technologies.

  17. A CREB-MPP7-AMOT Regulatory Axis Controls Muscle Stem Cell Expansion and Self-Renewal Competence

    Directory of Open Access Journals (Sweden)

    Lydia Li

    2017-10-01

    Full Text Available Summary: Skeletal muscle regeneration requires resident muscle stem cells, termed satellite cells (SCs. SCs are largely quiescent during homeostasis yet become activated upon injury to supply myonuclei and self-renewed SCs. Molecular mechanisms underlying the competence of SCs to proliferate and self-renew in response to injury remain unclear. Here, we show that CREB activity establishes proliferative potential during SC quiescence. SCs with inhibited CREB activity remain quiescent and positioned in their niche, but upon injury, they cannot enter or maintain a proliferative state for expansion and self-renewal. We demonstrate mechanistically that Mpp7 is a CREB target and its functional mediator. MPP7 loss affects the level and sub-cellular localization of AMOT and YAP1 in quiescent SCs. Furthermore, MPP7 and AMOT are required for YAP1 nuclear accumulation, and the three are individually required for a proliferative state in myoblasts. We propose that the CREB-MPP7-AMOT-YAP1 axis establishes the competence of quiescent SCs to expand and self-renew, thereby preserving stem cell function. : Satellite cells are quiescent muscle stem cells that have the ability to regenerate muscles after injury. Li and Fan reveal an MPP7-AMOT-YAP1 regulatory axis that acts downstream of CREB to instill satellite cell competence. They also show how this regulatory axis prepares satellite cells for robust muscle regeneration after injury.

  18. DC Distributed Power Systems. Analysis, Design and Control for a Renewable Energy System

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Per

    2002-12-01

    Renewable energy systems are likely to become wide spread in the future due to environmental demands. As a consequence of the dispersed nature of renewable energy systems, this implies that there will be a distributed generation of electric power. Since most of the distributed electrical energy sources do not provide their electric power at line frequency and voltage, a DC bus is a useful common connection for several such sources. Due to the differences in output voltage among the sources, depending on both the type of source and their actual operating point, the sources are connected to the DC power system via power electronic converters. The intention behind the presented work is not to replace the existing AC power system, but to include local DC power systems. The AC and DC power systems are connected at some points in the network. The renewable energy sources are weak compared to the present hydro power and nuclear power plants, resulting in a need of power conditioning before the renewable energy is fed to the transmission lines. The benefit of such an approach is that power conditioning is applied on a central level, i.e. at the interface between the AC and DC power systems. The thesis starts with an overview of related work. Present DC transmission systems are discussed and investigated in simulations. Then, different methods for load sharing and voltage control are discussed. Especially, the voltage droop control scheme is examined thoroughly. Since the droop control method does not require any high-speed communication between sources and loads, this is considered the most suitable for DC distributed power systems. The voltage feed back design of the controller also results in a specification of the DC bus capacitors (equivalents to DC link capacitors of single converters) needed for filtering. If the converters in the DC distribution system are equipped with capacitors selected from this design criterion and if the DC bus impedance is neglected, the

  19. Functional self-assembled lipidic systems derived from renewable resources.

    Science.gov (United States)

    Silverman, Julian R; Samateh, Malick; John, George

    2016-01-01

    Self-assembled lipidic amphiphile systems can create a variety of multi-functional soft materials with value-added properties. When employing natural reagents and following biocatalytic syntheses, self-assembling monomers may be inherently designed for degradation, making them potential alternatives to conventional and persistent polymers. By using non-covalent forces, self-assembled amphiphiles can form nanotubes, fibers, and other stimuli responsive architectures prime for further applied research and incorporation into commercial products. By viewing these lipid derivatives under a lens of green principles, there is the hope that in developing a structure-function relationship and functional smart materials that research may remain safe, economic, and efficient.

  20. Advancing System Flexibility for High Penetration Renewable Integration

    Energy Technology Data Exchange (ETDEWEB)

    Milligan, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Frew, Bethany [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhou, Ella [National Renewable Energy Lab. (NREL), Golden, CO (United States); Arent, Douglas J. [Joint Inst. for Strategic Energy Analysis, Golden, CO (United States)

    2015-10-01

    This report summarizes some of the issues discussed during the engagement on power system flexibility. By design, the focus is on flexibility options used in the United States. Exploration of whether and how U.S. experiences can inform Chinese energy planning will be part of the continuing project, and will benefit from the knowledge base provided by this report. We believe the initial stage of collaboration represented in this report has successfully started a process of mutual understanding, helping Chinese researchers to begin evaluating how lessons learned in other countries might translate to China's unique geographic, economic, social, and political contexts.

  1. Feasibility study on renewable energy systems and selected insulation applications : smart solutions for energy saving

    OpenAIRE

    Cuadra Fonseca, Sergio

    2013-01-01

    Energy represents a big challenge for future generations; not only mineral and fossil energy sources are being exhausted, but also GHG emissions pollute the environment and disrupt life natural cycles bringing serious irreversible impacts on earth. Renewable energy sources, on the other hand, are unexhausted and free of pollution; solar power systems play an important role in the generation of clean energy, being one of the most cost-effective solutions. Besides, solar power systems have ...

  2. Renewable energy off-grid power systems: options for energy suppliers

    International Nuclear Information System (INIS)

    Trouchet, K.

    1992-01-01

    SURVIVOR ENERGY SYSTEMS package a range of wind-based renewable energy systems for the supply of 24-hour power to off-grid homesteads and communities. This paper presents a leasing package for these power users and illustrates their cost effectiveness in comparison with stand-alone diesel and comparative hybrid power options. This offer is seen as a alternative for energy planners and supply agencies for their off-grid clients. 6 refs., 3 tabs., 3 figs

  3. Redesign Electricity Market for the Next Generation Power System of Renewable Energy and Distributed Storage Technologies

    DEFF Research Database (Denmark)

    Feng, Donghan; Xu, Zhao; Østergaard, Jacob

    2010-01-01

    This paper proposes a stochastic time-series based method to simulate the volatility of intermittent renewable generation and distributed storage devices along timeline. The proposed method can calculate the optimal timeline for different electricity markets and power systems. In practice......, the proposed method is potentially useful for designing market rules and evaluating different design options. Following works is underway on application and simulation of proposed method using the realistic distribution system of Bornholm Island in Denmark....

  4. Layered double hydroxide nanoparticles promote self-renewal of mouse embryonic stem cells through the PI3K signaling pathway

    Science.gov (United States)

    Wu, Youjun; Zhu, Rongrong; Zhou, Yang; Zhang, Jun; Wang, Wenrui; Sun, Xiaoyu; Wu, Xianzheng; Cheng, Liming; Zhang, Jing; Wang, Shilong

    2015-06-01

    Embryonic stem cells (ESCs) hold great potential for regenerative medicine due to their two unique characteristics: self-renewal and pluripotency. Several groups of nanoparticles have shown promising applications in directing the stem cell fate. Herein, we investigated the cellular effects of layered double hydroxide nanoparticles (LDH NPs) on mouse ESCs (mESCs) and the associated molecular mechanisms. Mg-Al-LDH NPs with an average diameter of ~100 nm were prepared by hydrothermal methods. To determine the influences of LDH NPs on mESCs, cellular cytotoxicity, self-renewal, differentiation potential, and the possible signaling pathways were explored. Evaluation of cell viability, lactate dehydrogenase release, ROS generation and apoptosis demonstrated the low cytotoxicity of LDH NPs. The alkaline phosphatase activity and the expression of pluripotency genes in mESCs were examined, which indicated that exposure to LDH NPs could support self-renewal and inhibit spontaneous differentiation of mESCs under feeder-free culture conditions. The self-renewal promotion was further proved to be independent of the leukemia inhibitory factor (LIF). Furthermore, cells treated with LDH NPs maintained the potential to differentiate into all three germ layers both in vitro and in vivo through formation of embryoid bodies and teratomas. In addition, we observed that LDH NPs initiated the activation of the PI3K/Akt pathway, while treatment with the PI3K inhibitor LY294002 could block the effects of LDH NPs on mESCs. The results confirmed that the promotion of self-renewal by LDH NPs was associated with activation of the PI3K/Akt signaling pathway. Altogether, our studies identified a new role of LDH NPs in maintaining self-renewal of mouse ES cells which could potentially be applied in stem cell research.Embryonic stem cells (ESCs) hold great potential for regenerative medicine due to their two unique characteristics: self-renewal and pluripotency. Several groups of nanoparticles

  5. Distinct Stromal Cell Factor Combinations Can Separately Control Hematopoietic Stem Cell Survival, Proliferation, and Self-Renewal

    Directory of Open Access Journals (Sweden)

    Stefan Wohrer

    2014-06-01

    Full Text Available Hematopoietic stem cells (HSCs are identified by their ability to sustain prolonged blood cell production in vivo, although recent evidence suggests that durable self-renewal (DSR is shared by HSC subtypes with distinct self-perpetuating differentiation programs. Net expansions of DSR-HSCs occur in vivo, but molecularly defined conditions that support similar responses in vitro are lacking. We hypothesized that this might require a combination of factors that differentially promote HSC viability, proliferation, and self-renewal. We now demonstrate that HSC survival and maintenance of DSR potential are variably supported by different Steel factor (SF-containing cocktails with similar HSC-mitogenic activities. In addition, stromal cells produce other factors, including nerve growth factor and collagen 1, that can antagonize the apoptosis of initially quiescent adult HSCs and, in combination with SF and interleukin-11, produce >15-fold net expansions of DSR-HSCs ex vivo within 7 days. These findings point to the molecular basis of HSC control and expansion.

  6. The effect of real-time pricing on load shifting in a highly renewable power system dominated by generation from the renewable sources of wind and photovoltaics

    Science.gov (United States)

    Kies, Alexander; Brown, Tom; Schlachtberger, David; Schramm, Stefan

    2017-04-01

    The supply-demand imbalance is a major concern in the presence of large shares of highly variable renewable generation from sources like wind and photovoltaics (PV) in power systems. Other than the measures on the generation side, such as flexible backup generation or energy storage, sector coupling or demand side management are the most likely option to counter imbalances, therefore to ease the integration of renewable generation. Demand side management usually refers to load shifting, which comprises the reaction of electricity consumers to price fluctuations. In this work, we derive a novel methodology to model the interplay of load shifting and provided incentives via real-time pricing in highly renewable power systems. We use weather data to simulate generation from the renewable sources of wind and photovoltaics, as well as historical load data, split into different consumption categories, such as, heating, cooling, domestic, etc., to model a simplified power system. Together with renewable power forecast data, a simple market model and approaches to incorporate sector coupling [1] and load shifting [2,3], we model the interplay of incentives and load shifting for different scenarios (e.g., in dependency of the risk-aversion of consumers or the forecast horizon) and demonstrate the practical benefits of load shifting. First, we introduce the novel methodology and compare it with existing approaches. Secondly, we show results of numerical simulations on the effects of load shifting: It supports the integration of PV power by providing a storage, which characteristics can be described as "daily" and provides a significant amount of balancing potential. Lastly, we propose an experimental setup to obtain empirical data on end-consumer load-shifting behaviour in response to price incentives. References [1] Brown, T., Schlachtberger, D., Kies. A., Greiner, M., Sector coupling in a highly renewable European energy system, Proc. of the 15th International Workshop on

  7. The death-inducer obliterator 1 (Dido1) gene regulates embryonic stem cell self-renewal.

    Science.gov (United States)

    Liu, Yinyin; Kim, Hyeung; Liang, Jiancong; Lu, Weisi; Ouyang, Bin; Liu, Dan; Songyang, Zhou

    2014-02-21

    The regulatory network of factors that center on master transcription factors such as Oct4, Nanog, and Sox2 help maintain embryonic stem (ES) cells and ensure their pluripotency. The target genes of these master transcription factors define the ES cell transcriptional landscape. In this study, we report our findings that Dido1, a target of canonical transcription factors such as Oct4, Sox2, and Nanog, plays an important role in regulating ES cell maintenance. We found that depletion of Dido1 in mouse ES cells led to differentiation, and ectopic expression of Dido1 inhibited differentiation induced by leukemia inhibitory factor withdrawal. We further demonstrated that whereas Nanog and Oct4 could occupy the Dido1 locus and promote its transcription, Dido1 could also target to the loci of pluripotency factors such as Nanog and Oct4 and positively regulate their expression. Through this feedback and feedforward loop, Dido1 is able to regulate self-renewal of mouse ES cells.

  8. Advancing System Flexibility for High Penetration Renewable Integration (Chinese Translation)

    Energy Technology Data Exchange (ETDEWEB)

    Milligan, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Frew, Bethany [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhou, Ella [National Renewable Energy Lab. (NREL), Golden, CO (United States); Arent, Douglas J. [Joint Inst. for Strategic Energy Analysis, Golden, CO (United States)

    2015-10-01

    This is a Chinese translation of NREL/TP-6A20-64864. This report summarizes some of the issues discussed during the engagement on power system flexibility. By design, the focus is on flexibility options used in the United States. Exploration of whether and how U.S. experiences can inform Chinese energy planning will be part of the continuing project, and will benefit from the knowledge base provided by this report. We believe the initial stage of collaboration represented in this report has successfully started a process of mutual understanding, helping Chinese researchers to begin evaluating how lessons learned in other countries might translate to China's unique geographic, economic, social, and political contexts.

  9. Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells.

    Science.gov (United States)

    Rambhatla, Lakshmi; Ram-Mohan, Sumati; Cheng, Jennifer J; Sherley, James L

    2005-04-15

    Because they are long-lived and cycle continuously, adult stem cells (ASCs) are predicted as the most common precursor for cancers in adult mammalian tissues. Two unique attributes have been proposed to restrict the carcinogenic potential of ASCs. These are asymmetric self-renewal that limits their number and immortal DNA strand cosegregation that limits their accumulation of mutations due to DNA replication errors. Until recently, the molecular basis and regulation of these important ASC-specific functions were unknown. We developed engineered cultured cells that exhibit asymmetric self-renewal and immortal DNA strand cosegregation. These model cells were used to show that both ASC-specific functions are regulated by the p53 cancer gene. Previously, we proposed that IMP dehydrogenase (IMPDH) was an essential factor for p53-dependent asymmetric self-renewal. We now confirm this proposal and provide quantitative evidence that asymmetric self-renewal is acutely sensitive to even modest changes in IMPDH expression. These analyses reveal that immortal DNA strand cosegregation is also regulated by IMPDH and confirm the original implicit precept that immortal DNA strand cosegregation is specific to cells undergoing asymmetric self-renewal (i.e., ASCs). With IMPDH being the rate-determining enzyme for guanine ribonucleotide (rGNP) biosynthesis, its requirement implicates rGNPs as important regulators of ASC asymmetric self-renewal and immortal DNA strand cosegregation. An in silico analysis of global gene expression data from human cancer cell lines underscored the importance of p53-IMPDH-rGNP regulation for normal tissue cell kinetics, providing further support for the concept that ASCs are key targets for adult tissue carcinogenesis.

  10. Impacts of optimal energy storage deployment and network reconfiguration on renewable integration level in distribution systems

    International Nuclear Information System (INIS)

    Santos, Sérgio F.; Fitiwi, Desta Z.; Cruz, Marco R.M.; Cabrita, Carlos M.P.; Catalão, João P.S.

    2017-01-01

    Highlights: • A dynamic and multi-objective stochastic mixed integer linear programming model is developed. • A new mechanism to quantify the impacts of network flexibility and ESS deployments on RES integration is presented. • Optimal integration of ESSs dramatically increases the level and the optimal exploitation of renewable DGs. • As high as 90% of RES integration level may be possible in distribution network systems. • Joint DG and ESS installations along with optimal network reconfiguration greatly contribute to voltage stability. - Abstract: Nowadays, there is a wide consensus about integrating more renewable energy sources-RESs to solve a multitude of global concerns such as meeting an increasing demand for electricity, reducing energy security and heavy dependence on fossil fuels for energy production, and reducing the overall carbon footprint of power production. Framed in this context, the coordination of RES integration with energy storage systems (ESSs), along with the network’s switching capability and/or reinforcement, is expected to significantly improve system flexibility, thereby increasing the capability of the system in accommodating large-scale RES power. Hence, this paper presents a novel mechanism to quantify the impacts of network switching and/or reinforcement as well as deployment of ESSs on the level of renewable power integrated in the system. To carry out this analysis, a dynamic and multi-objective stochastic mixed integer linear programming (S-MILP) model is developed, which jointly takes the optimal deployment of RES-based DGs and ESSs into account in coordination with distribution network reinforcement and/or reconfiguration. The IEEE 119-bus test system is used as a case study. Numerical results clearly show the capability of ESS deployment in dramatically increasing the level of renewable DGs integrated in the system. Although case-dependent, the impact of network reconfiguration on RES power integration is not

  11. Seasonal shifting of surplus renewable energy in a power system located in a cold region

    Directory of Open Access Journals (Sweden)

    Jorge Morel

    2014-10-01

    Full Text Available The Fukushima nuclear disaster in 2011 changed Japan's strategy for reducing CO2 emissions. The government is now placing more emphasis on the development of nonCO2-emitting distributed generation systems such as wind, solar, and tidal power to reduce greenhouse gas emissions and guarantee electricity supply in the case of a natural disaster. This paper proposes a strategy for the exploitation of wind, solar, and tidal resources in a cold region in Japan by utilizing surplus energy from the summer and spring during winter. It also aims to determine the most favorable energy mix of these renewable sources and storage system types. The study is performed by calculating hourly demand and renewable energy supply for the city in one year, which is based on actual data of demand, solar irradiation, wind speeds, and tidal current speeds. The costs of the components of the renewable power plants and storage systems are considered, and different proportions of generation outputs are evaluated with different types of storage systems. According to results, the configuration containing the hydrogen storage system using organic chemical hydride methylcyclohexane (OCHM is the most economical but is still more expensive than one using a conventional generation system. Moreover, we confirm that the cost of CO2 emissions is the key element for leveling the playing field between conventional and renewable generation from an economic perspective. The cost of CO2 emissions to public health as well as those costs related to the interruption of services during a catastrophe must be carefully calculated with other issues from conventional power projects to perform a precise comparative evaluation between both types of generation systems.

  12. Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells

    Science.gov (United States)

    Lu, Yu; Loh, Yuin-Han; Li, Hu; Cesana, Marcella; Ficarro, Scott B.; Parikh, Jignesh R.; Salomonis, Nathan; Toh, Cheng-Xu Delon; Andreadis, Stelios T.; Luckey, C. John; Collins, James J.; Daley, George Q.; Marto, Jarrod A.

    2014-01-01

    Summary Alternative RNA splicing (AS) regulates proteome diversity, including isoform-specific expression of several pluripotency genes. Here, we integrated global gene expression and proteomic analyses and identified a molecular signature suggesting a central role for AS in maintaining human pluripotent stem cell (hPSC) self-renewal. We demonstrate the splicing factor SFRS2 is an OCT4 target gene required for pluripotency. SFRS2 regulates AS of the methyl-CpG-binding protein MBD2, whose isoforms play opposing roles in maintenance of, and reprogramming to, pluripotency. While both MDB2a and MBD2c are enriched at the OCT4 and NANOG promoters, MBD2a preferentially interacts with repressive NuRD chromatin remodeling factors and promotes hPSC differentiation, whereas overexpression of MBD2c enhances reprogramming of fibroblasts to pluripotency. The miR-301 and miR-302 families provide additional regulation by targeting SFRS2 and MDB2a. These data suggest that OCT4, SFRS2, and MBD2 participate in a positive feedback loop, regulating proteome diversity complexity in support of hPSC self-renewal and reprogramming. PMID:24813856

  13. Renewable energy sources monitoring systems; Sistema de monitoramento de fontes de energias renovaveis

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Teofilo Miguel de; Canto, Mario Afonso Ribeiro do [Universidade Estadual Paulista (UNESP), Guaratingueta, SP (Brazil). Centro de Energias Renovaveis], e-mail: teofilo@feg.unesp.br

    2004-07-01

    The development of techniques and products for use of sources of energy renewed it depends on economic and technical parameters that result of revenue analyses and acting for its improvement. With the objective of to provide and to facilitate the access the information on the future acting of products and techniques of generation of energy of alternative sources and you renewed of energy, it was developed a collection project and storage of data of reduced cost and of facilitated visualization. The system developed in platform of software LabView controls a system of acquisition of data through interface RS-232 and it stores the data in files Excel or Files text, depending on the application type. The system of acquisition of data consists of a circuit of conditioning of analogic signs for digital signs, a control circuit and a circuit of communication type interface serial asynchronous RS-232. (author)

  14. Integration of renewable energies into the power supply system; Integration erneuerbarer Energien in das Stromversorgungssystem

    Energy Technology Data Exchange (ETDEWEB)

    Neubarth, Juergen [e3 consult, Innsbruck (Austria)

    2011-08-15

    In contrast to the record breaking speed with which the German government presented its new energy concept in response to the Fukushima reactor disaster, the practical task of transforming our energy supply system will take decades. One of the greatest challenges involved in the energy turnaround will be that of integrating renewable energies into the power supply system. A holistic analysis and assessment of all aspects involved in this is therefore of utmost importance. Under the focal topic of its new publication ''Energie fuer Deutschland 2011'', Weltenergierat Deutschland e.V. presents a detailed summary of this challenge, thus providing a basis for further discussion. It shows that efficient integration of renewable energies must necessarily involve a combination of systems engineering and organisational measures.

  15. Use of Danish Heat Atlas and energy system models for exploring renewable energy scenarios

    DEFF Research Database (Denmark)

    Petrovic, Stefan; Karlsson, Kenneth Bernard

    2013-01-01

    networks in relation with significant heat saving measures that are capital intensive infrastructure investments require highly detailed decision - support tools. The Heat Atlas for Denmark provides a highly detailed database and includes heat demand and possible heat savings for about 2.5 million...... buildings with associated costs included. Energy systems modelling tools that incorporate economic, environmental, energy and engineering analysis of future energy systems are considered crucial for quantitative assessment of transitional scenarios towards future milestones, such as (i) EU 2020 goals...... of reducing greenhouse gas emissions, increasing share of renewable energy and improving energy efficiency and (ii) Denmark’s 2050 goals of covering entire energy supply by renewable energy. Optimization and simulation energy system models are currently used in Denmark. The present paper tends to provide...

  16. Renewability and emergy footprint at different spatial scales for innovative food systems in Europe

    DEFF Research Database (Denmark)

    Wright, Christina; Østergård, Hanne

    2016-01-01

    Food production is increasingly being challenged by limited resources of energy and land as well as bygrowing demand for food. In a future with less availability of fossil fuels, land area will become veryimportant for capturing the flow-limited renewable resources. Emergy assessment has been...... applied tocalculate scale dependent indicators, which account for the land area needed, if agricultural systems wereto be supported solely on renewable sources. These indicators are designated emergy footprints (EmFs)and expand the concept of support area defined previously in emergy accounting. The Em......-specific renewableempower density. A new indicator applying the EmF is the emergy overshoot factor, which estimatesthe ratio between EmF and the geographical system boundary (in ha). We apply this approach on threeinnovative food supply systems in Europe located at farms characterised by combining high diversity...

  17. Scheduling Model for Renewable Energy Sources Integration in an Insular Power System

    Directory of Open Access Journals (Sweden)

    Gerardo J. Osório

    2018-01-01

    Full Text Available Insular power systems represent an asset and an excellent starting point for the development and analysis of innovative tools and technologies. The integration of renewable energy resources that has taken place in several islands in the south of Europe, particularly in Portugal, has brought more uncertainty to production management. In this work, an innovative scheduling model is proposed, which considers the integration of wind and solar resources in an insular power system in Portugal, with a strong conventional generation basis. This study aims to show the benefits of increasing the integration of renewable energy resources in this insular power system, and the objectives are related to minimizing the time for which conventional generation is in operation, maximizing profits, reducing production costs, and consequently, reducing greenhouse gas emissions.

  18. Aubergine and piRNAs promote germline stem cell self-renewal by repressing the proto-oncogene Cbl.

    Science.gov (United States)

    Rojas-Ríos, Patricia; Chartier, Aymeric; Pierson, Stéphanie; Simonelig, Martine

    2017-11-02

    PIWI proteins play essential roles in germ cells and stem cell lineages. In Drosophila , Piwi is required in somatic niche cells and germline stem cells (GSCs) to support GSC self-renewal and differentiation. Whether and how other PIWI proteins are involved in GSC biology remains unknown. Here, we show that Aubergine (Aub), another PIWI protein, is intrinsically required in GSCs for their self-renewal and differentiation. Aub needs to be loaded with piRNAs to control GSC self-renewal and acts through direct mRNA regulation. We identify the Cbl proto-oncogene, a regulator of mammalian hematopoietic stem cells, as a novel GSC differentiation factor. Aub stimulates GSC self-renewal by repressing Cbl mRNA translation and does so in part through recruitment of the CCR4-NOT complex. This study reveals the role of piRNAs and PIWI proteins in controlling stem cell homeostasis via translational repression and highlights piRNAs as major post-transcriptional regulators in key developmental decisions. © 2017 The Authors. Published under the terms of the CC BY 4.0 license.

  19. Model documentation: Renewable Fuels Module of the National Energy Modeling System

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    This report documents the objectives, analytical approach, and design of the National Energy Modeling System (NEMS) Renewable Fuels Module (RFM) as it related to the production of the 1994 Annual Energy Outlook (AEO94) forecasts. The report catalogues and describes modeling assumptions, computational methodologies, data inputs, and parameter estimation techniques. A number of offline analyses used in lieu of RFM modeling components are also described. This documentation report serves two purposes. First, it is a reference document for model analysts, model users, and the public interested in the construction and application of the RFM. Second, it meets the legal requirement of the Energy Information Administration (EIA) to provide adequate documentation in support of its models. The RFM consists of six analytical submodules that represent each of the major renewable energy resources -- wood, municipal solid waste (MSW), solar energy, wind energy, geothermal energy, and alcohol fuels. Of these six, four are documented in the following chapters: municipal solid waste, wind, solar and biofuels. Geothermal and wood are not currently working components of NEMS. The purpose of the RFM is to define the technological and cost characteristics of renewable energy technologies, and to pass these characteristics to other NEMS modules for the determination of mid-term forecasted renewable energy demand.

  20. Model documentation renewable fuels module of the National Energy Modeling System

    Science.gov (United States)

    1995-06-01

    This report documents the objectives, analytical approach, and design of the National Energy Modeling System (NEMS) Renewable Fuels Module (RFM) as it relates to the production of the 1995 Annual Energy Outlook