WorldWideScience

Sample records for cell renewal systems

  1. System and method for integration of renewable energy and fuel cell for the production of electricity and hydrogen

    NARCIS (Netherlands)

    Hemmes, K.

    2007-01-01

    The invention relates to a system and method for integrating renewable energy and a fuel cell for the production of electricity and hydrogen, wherein this comprises the use of renewable energy as fluctuating energy source for the production of electricity and also comprises the use of at least one f

  2. Reversible solid oxide fuel cell for natural gas/renewable hybrid power generation systems

    Science.gov (United States)

    Luo, Yu; Shi, Yixiang; Zheng, Yi; Cai, Ningsheng

    2017-02-01

    Renewable energy (RE) is expected to be the major part of the future energy. Presently, the intermittence and fluctuation of RE lead to the limitation of its penetration. Reversible solid oxide fuel cell (RSOFC) as the energy storage device can effectively store the renewable energy and build a bidirectional connection with natural gas (NG). In this paper, the energy storage strategy was designed to improve the RE penetration and dynamic operation stability in a distributed system coupling wind generators, internal combustion engine, RSOFC and lithium-ion batteries. By compromising the relative deviation of power supply and demand, RE penetration, system efficiency and capacity requirement, the strategy that no more than 36% of the maximum wind power output is directly supplied to users and the other is stored by the combination of battery and reversible solid oxide fuel cell is optimal for the distributed system. In the case, the RE penetration reached 56.9% and the system efficiency reached 55.2%. The maximum relative deviation of power supply and demand is also lower than 4%, which is significantly superior to that in the wind curtailment case.

  3. Renewable Energy Systems

    DEFF Research Database (Denmark)

    Lund, Henrik

    2014-01-01

    are to be found when the electricity sector is combined with the heating and cooling sectors and/or the transportation sector. Moreover, the combination of electricity and gas infrastructures may play an important role in the design of future renewable energy systems. The paper illustrates why electricity smart......This paper presents the learning of a series of studies that analyse the problems and perspectives of converting the present energy system into a 100 % renewable energy system using a smart energy systems approach. As opposed to, for instance, the smart grid concept, which takes a sole focus...... on the electricity sector, smart energy systems include the entire energy system in its approach to identifying suitable energy infrastructure designs and operation strategies. The typical smart grid sole focus on the electricity sector often leads to the conclusion that transmission lines, flexible electricity...

  4. Renewable Energy Devices and Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Ionel, Dan M.

    2015-01-01

    applications are provided. Fuel cells, solar thermal, wave generators, and energy storage systems are also briefly presented and illustrated. Challenges and future trends for 2025 are summarized in a table for on-shore and off-shore wind energy, solar power, including photovoltaic and concentering, wave energy...... and the fundamental and increasing role of power electronics as an enabler for renewable energy integration, and for the future power system and smart grid. Recent examples of research and development, including new devices and system installations for utility power plants, as well for as residential and commercial......, fuel cells, and storage with batteries and hydrogen, respectively. Recommended further readings on topics of electric power engineering for renewable energy are included in a final section. This paper also represents an editorial introduction for two special issues of the Electric Power Component...

  5. Renewable Systems Interconnection: Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    Kroposki, B.; Margolis, R.; Kuswa, G.; Torres, J.; Bower, W.; Key, T.; Ton, D.

    2008-02-01

    The U.S. Department of Energy launched the Renewable Systems Interconnection (RSI) study in 2007 to address the challenges to high penetrations of distributed renewable energy technologies. The RSI study consists of 14 additional reports.

  6. Design, Operation, Control, and Economics of a Photovoltaic/Fuel Cell/Battery Hybrid Renewable Energy System for Automotive Applications

    Directory of Open Access Journals (Sweden)

    Zachary S. Whiteman

    2015-06-01

    Full Text Available Meeting rapidly growing global energy demand—without producing greenhouse gases or further diminishing the availability of non-renewable resources—requires the development of affordable low-emission renewable energy systems. Here, we develop a hybrid renewable energy system (HRES for automotive applications—specifically, a roof-installed photovoltaic (PV array combined with a PEM fuel cell/NiCd battery bus currently operating shuttle routes on the University of Delaware campus. The system’s overall operating objectives—meeting the total power demand of the bus and maintaining the desired state of charge (SOC of the NiCd battery—are achieved with appropriately designed controllers: a logic-based “algebraic controller” and a standard PI controller. The design, implementation, and performance of the hybrid system are demonstrated via simulation of real shuttle runs under various operating conditions. The results show that both control strategies perform equally well in enabling the HRES to meet its objectives under typical operating conditions, and under sudden cloud cover conditions; however, at consistently high bus speeds, battery SOC maintenance is better, and the system consumes less hydrogen, with PI control. An economic analysis of the PV investment necessary to realize the HRES design objectives indicates a return on investment of approximately 30% (a slight, but nonetheless positive, ~$550 profit over the bus lifetime in Newark, DE, establishing the economic viability of the proposed addition of a PV array to the existing University of Delaware fuel cell/battery bus.

  7. Adaptive control paradigm for photovoltaic and solid oxide fuel cell in a grid-integrated hybrid renewable energy system

    Science.gov (United States)

    Khan, Laiq

    2017-01-01

    The hybrid power system (HPS) is an emerging power generation scheme due to the plentiful availability of renewable energy sources. Renewable energy sources are characterized as highly intermittent in nature due to meteorological conditions, while the domestic load also behaves in a quite uncertain manner. In this scenario, to maintain the balance between generation and load, the development of an intelligent and adaptive control algorithm has preoccupied power engineers and researchers. This paper proposes a Hermite wavelet embedded NeuroFuzzy indirect adaptive MPPT (maximum power point tracking) control of photovoltaic (PV) systems to extract maximum power and a Hermite wavelet incorporated NeuroFuzzy indirect adaptive control of Solid Oxide Fuel Cells (SOFC) to obtain a swift response in a grid-connected hybrid power system. A comprehensive simulation testbed for a grid-connected hybrid power system (wind turbine, PV cells, SOFC, electrolyzer, battery storage system, supercapacitor (SC), micro-turbine (MT) and domestic load) is developed in Matlab/Simulink. The robustness and superiority of the proposed indirect adaptive control paradigm are evaluated through simulation results in a grid-connected hybrid power system testbed by comparison with a conventional PI (proportional and integral) control system. The simulation results verify the effectiveness of the proposed control paradigm. PMID:28329015

  8. Adaptive control paradigm for photovoltaic and solid oxide fuel cell in a grid-integrated hybrid renewable energy system.

    Science.gov (United States)

    Mumtaz, Sidra; Khan, Laiq

    2017-01-01

    The hybrid power system (HPS) is an emerging power generation scheme due to the plentiful availability of renewable energy sources. Renewable energy sources are characterized as highly intermittent in nature due to meteorological conditions, while the domestic load also behaves in a quite uncertain manner. In this scenario, to maintain the balance between generation and load, the development of an intelligent and adaptive control algorithm has preoccupied power engineers and researchers. This paper proposes a Hermite wavelet embedded NeuroFuzzy indirect adaptive MPPT (maximum power point tracking) control of photovoltaic (PV) systems to extract maximum power and a Hermite wavelet incorporated NeuroFuzzy indirect adaptive control of Solid Oxide Fuel Cells (SOFC) to obtain a swift response in a grid-connected hybrid power system. A comprehensive simulation testbed for a grid-connected hybrid power system (wind turbine, PV cells, SOFC, electrolyzer, battery storage system, supercapacitor (SC), micro-turbine (MT) and domestic load) is developed in Matlab/Simulink. The robustness and superiority of the proposed indirect adaptive control paradigm are evaluated through simulation results in a grid-connected hybrid power system testbed by comparison with a conventional PI (proportional and integral) control system. The simulation results verify the effectiveness of the proposed control paradigm.

  9. Adult neural stem cells: Long-term self-renewal, replenishment by the immune system, or both?

    Science.gov (United States)

    Beltz, Barbara S; Cockey, Emily L; Li, Jingjing; Platto, Jody F; Ramos, Kristina A; Benton, Jeanne L

    2015-05-01

    The current model of adult neurogenesis in mammals suggests that adult-born neurons are generated by stem cells that undergo long-term self-renewal, and that a lifetime supply of stem cells resides in the brain. In contrast, it has recently been demonstrated that adult-born neurons in crayfish are generated by precursors originating in the immune system. This is particularly interesting because studies done many years ago suggest that a similar mechanism might exist in rodents and humans, with bone marrow providing stem cells that can generate neurons. However, the relevance of these findings for natural mechanisms underlying adult neurogenesis in mammals is not clear, because of uncertainties at many levels. We argue here that the recent findings in crayfish send a strong signal to re-examine existing data from rodents and humans, and to design new experiments that will directly test the contributions of the immune system to adult neurogenesis in mammals.

  10. Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks.

    Science.gov (United States)

    Dowell, Karen G; Simons, Allen K; Bai, Hao; Kell, Braden; Wang, Zack Z; Yun, Kyuson; Hibbs, Matthew A

    2014-05-01

    Embryonic stem cells (ESCs), characterized by their ability to both self-renew and differentiate into multiple cell lineages, are a powerful model for biomedical research and developmental biology. Human and mouse ESCs share many features, yet have distinctive aspects, including fundamental differences in the signaling pathways and cell cycle controls that support self-renewal. Here, we explore the molecular basis of human ESC self-renewal using Bayesian network machine learning to integrate cell-type-specific, high-throughput data for gene function discovery. We integrated high-throughput ESC data from 83 human studies (~1.8 million data points collected under 1,100 conditions) and 62 mouse studies (~2.4 million data points collected under 1,085 conditions) into separate human and mouse predictive networks focused on ESC self-renewal to analyze shared and distinct functional relationships among protein-coding gene orthologs. Computational evaluations show that these networks are highly accurate, literature validation confirms their biological relevance, and reverse transcriptase polymerase chain reaction (RT-PCR) validation supports our predictions. Our results reflect the importance of key regulatory genes known to be strongly associated with self-renewal and pluripotency in both species (e.g., POU5F1, SOX2, and NANOG), identify metabolic differences between species (e.g., threonine metabolism), clarify differences between human and mouse ESC developmental signaling pathways (e.g., leukemia inhibitory factor (LIF)-activated JAK/STAT in mouse; NODAL/ACTIVIN-A-activated fibroblast growth factor in human), and reveal many novel genes and pathways predicted to be functionally associated with self-renewal in each species. These interactive networks are available online at www.StemSight.org for stem cell researchers to develop new hypotheses, discover potential mechanisms involving sparsely annotated genes, and prioritize genes of interest for experimental validation.

  11. Renewable and efficient electric power systems

    CERN Document Server

    Masters, Gilbert M

    2013-01-01

    A solid, quantitative, practical introduction to a wide range of renewable energy systems-in a completely updated, new edition The second edition of Renewable and Efficient Electric Power Systems provides a solid, quantitative, practical introduction to a wide range of renewable energy systems. For each topic, essential theoretical background is introduced, practical engineering considerations associated with designing systems and predicting their performance are provided, and methods for evaluating the economics of these systems are presented. While the book focuses on

  12. Modeling and Optimization of Renewable and Hybrid Fuel Cell Systems for Space Power and Propulsion

    Science.gov (United States)

    2010-11-14

    funded by a brazilian company partner (NILKO Metalurgia Ltda). The electrolyzer was purchased by the project from Proton Energy (USA). 3 rd year...partner (NILKO Metalurgia Ltda). The electrolyzer was purchased by the project from Proton Energy (USA) and adapted to the system with a DC-AC

  13. Identification of a novel gene signature of ES cells self-renewal fluctuation through system-wide analysis.

    Directory of Open Access Journals (Sweden)

    Luigi Cerulo

    Full Text Available Embryonic Stem cells (ESCs can be differentiated into ectoderm, endoderm, and mesoderm derivatives, producing the majority of cell types. In regular culture conditions, ESCs' self-renewal is maintained through molecules that inhibit spontaneous differentiation enabling long-term cellular expansion. This undifferentiating condition is characterized by multiple metastable states that fluctuate between self-renewal and differentiation balance. Here, we aim to characterize the high-pluripotent ESC metastate marked by the expression of Zscan4 through a supervised machine learning framework based on an ensemble of support vector machine (SVM classifiers. Our study revealed a leukaemia inhibitor factor (Lif dependent not-canonical pluripotency signature (AF067063, BC061212, Dub1, Eif1a, Gm12794, Gm13871, Gm4340, Gm4850, Tcstv1/3, and Zfp352, that specifically marks Zscan4 ESCs' fluctuation. This novel ESC metastate is enhanced by high-pluripotency culture conditions obtained through Extracellular signal Regulated-Kinase (ERK and Glycogen synthase kinase-3 (Gsk-3 signaling inhibition (2i. Significantly, we reported that the conditional ablation of the novel ESC metastate marked by the expression of Gm12794 is required for ESCs self-renewal maintenance. In conclusion, we extend the comprehension of ESCs biology through the identification of a novel molecular signature associated to pluripotency programming.

  14. Distributed-dispersed renewable energy systems and novel control strategies

    Science.gov (United States)

    Aljankawey, Abdualah S.

    Renewable green-energy systems are re-emerging as viable economic alternative sources of environmentally safe power generation in place of conventional fossil fuels. In terms of power quality and safety, this research investigates a number of renewable green-energy (wind, photovoltaic and fuel cells) interface schemes and control strategies that ensure maximum energy utilization, voltage and frequency stabilization and minimum impact on the host electric grid systems. The research key objectives are to study efficient and robust renewable energy converter schemes with associated control strategies and validate their operations for both stand-alone and electric utility grid interfacing. The research work investigates both stand-alone and grid connected renewable green-energy utilization schemes with a number of power electronic converter topologies and robust control schemes for both dispersed and hybrid renewable energy systems. Different sample study systems and control strategies are digitally simulated and fully validated using the MATLAB-Simulink-SimPower environment.

  15. Power Electronics for Renewable Energy Systems

    DEFF Research Database (Denmark)

    Choi, U. M.; Lee, K. B.; Blaabjerg, Frede

    2012-01-01

    The use of renewable energy sources are increased because of the depletion of natural resources and the increasing pollution level from energy production. The wind energy and the solar energy are most widely used among the renewable energy sources. Power electronics is needed in almost all kinds...... of renewable energy system. It controls the renewable source and interfaces with the load effectively, which can be grid-connected or van work in stand-alone mode. In this presentation, overview of wind and photovoltaic energy systems are introduced. Next, the power electronic circuits behind the most common...

  16. A focus on parietal cells as a renewing cell population

    Institute of Scientific and Technical Information of China (English)

    Sherif; M; Karam

    2010-01-01

    The fact that the acidsecreting parietal cells undergo continuous renewal has been ignored by many gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using 3Hthymidine radioautography in combination with electron microscopy, it was possible to demonstrate that parietal cells belong to a continuously renewing epithelial cell lineage. In the gastric glands, stem cells anchored in the isthmus region are responsible for the production of parietal cells...

  17. Potential of renewable energy systems in China

    DEFF Research Database (Denmark)

    Liu, Wen; Lund, Henrik; Mathiesen, Brian Vad

    2011-01-01

    Along with high-speed economic development and increasing energy consumption, the Chinese Government faces a growing pressure to maintain the balance between energy supply and demand. In 2009, China has become both the largest energy consumer and CO2 emitting country in the world. In this case...... system has demonstrated the possibility of converting into a 100% renewable energy system. This paper discusses the perspective of renewable energy in China firstly, and then analyses whether it is suitable to adopt similar methodologies applied in other countries as China approaches a renewable energy......, the inappropriate energy consumption structure should be changed. As an alternative, a suitable infrastructure for the implementation of renewable energy may serve as a long-term sustainable solution. The perspective of a 100% renewable energy system has been analyzed and discussed in some countries previously...

  18. Spermatogonial stem cell renewal following irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Fabrikant, J.I.

    1979-05-01

    The spermatogonial cell renewal system can maintain function and a steady level of cell population for relatively long periods of continuous low-level irradiation indicating that there does not appear to be a serious accumulation, over many generations, of damage affecting proliferation. Provided the dose-rate is quite low, there is an effective selective removal of damaged cells with almost complete repair of cellular nonlethal damage. At dose-rates greater than 2 rad/day, spermatogonia are very sensitive to radiation death, and the main reason for the low tolerance to continuous stress could, in part, be the limited extent of compensatory mechanisms regulating spermatogonial cell production. However, there is some capacity to change the patterns of cellular proliferation while still remaining under homeostatic control, and this capacity appears to reside in the relatively radioresistant A/sub s/ stem-cell population. Little is known about the extent to which the spermatogonial cell population can repair nonlethal cellular radiation damage accumulated under continuous stress affecting the regenerative capacity of the tissue. After acute exposure, a minimum number of surviving type A/sub s/ stem-cells are required to repopulate the functional seminiferous epithelium, regeneration proceeds along an ordered cell stage sequence, and is dependent on the time required for all stages from type A/sub s/ spermatogonia to mature spermatozoa. Under continuous irradiation, provided the dose-rate is not too high, the repopulating ability of the seminiferous epithelium is maintained, in the presence of injury, due to initial repair and long-term repair of cellular radiation damage. There is evidence for initial repair, since a dose-rate effect exists in type A survival, at low doses. Long-term repair occurs due to differential radiosensitivities of spermatogonia.

  19. Internet Renewable energy Information System (IRIS)

    DEFF Research Database (Denmark)

    Bäurle, Britta; Nielsen, Vilhjalmur; Ménard, Lionel

    1999-01-01

    Even though the Internet is now a widely accessible data source, the unorganised flood of information makes a specific request e.g. for renewable energy products inefficient. In addition, existing databases on renewable energies are often old and incomplete. The objective of IRIS has been...... to organise and retrieve renewable energy product information on the Internet instead of collecting it manually. Updating coincides with the self interestself-interest of manufacturers to present their latest renewable energy products on their own HTML documents. IRIS is based on a set of powerful tools...... on biogas systems in order to become part of IRIS. IRIS has been developed in the context of the project „AVALANCHE" which is partly funded under the JOULE programme of the European Commission DGXII.Keywords: Renewable Energy Technologies - Electronic Commerce - Information System - META-tags...

  20. Fuel Cells for Balancing Fluctuation Renewable Energy Sources

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad

    2007-01-01

    In the perspective of using fuel cells for integration of fluctuating renewable energy the SOFCs are the most promising. These cells have the advantage of significantly higher electricity efficiency than competing technologies and fuel flexibility. Fuel cells in general also have the advantage of...... with hydrogen production or electric cars, and on the other hand using biomass and bio fuels [11]. Fuel cells can have an important role in these future energy systems.......In the perspective of using fuel cells for integration of fluctuating renewable energy the SOFCs are the most promising. These cells have the advantage of significantly higher electricity efficiency than competing technologies and fuel flexibility. Fuel cells in general also have the advantage...... flexibility, such as SOFCs, heat pumps and heat storage technologies are more important than storing electricity as hydrogen via electrolysis in energy systems with high amounts of wind [12]. Unnecessary energy conversions should be avoided. However in future energy systems with wind providing more than 50...

  1. Introduction to Renewable Energy Systems

    DEFF Research Database (Denmark)

    Ma, Ke; Yang, Yongheng; Blaabjerg, Frede

    2014-01-01

    In this chapter, the state-of-the-arts developments of renewable energy are reviewed in respect to the installed power and market share, where wind power and photovoltaic power generation are the main focuses due to the fast growing speed and large share of installed capacity. Some basic principles...

  2. The Palm Desert renewable [hydrogen] transportation system

    Energy Technology Data Exchange (ETDEWEB)

    Chamberlin, C.E.; Lehman, P. [Humboldt State Univ., Arcata, CA (United States). Schatz Energy Research Center

    1998-08-01

    This paper describes the Schatz Energy Research Center (SERC) progress on the Palm Desert Renewable Hydrogen Transportation System Project for the period June 1997 through May 1998. The project began in March 1996. The goal of the Palm Desert Project is to develop a clean and sustainable transportation system for a community. The project demonstrates the practical utility of hydrogen as a transportation fuel and the proton exchange membrane (PEM) fuel cell as a vehicle power system. The project includes designing and building 4 fuel cell powered vehicles, a solar hydrogen generating and refueling station, and a fuel cell vehicle diagnostic center. Over this last year, SERC has built a fuel cell powered neighborhood electric vehicle and delivered it to the City of Palm Desert. The design of the hydrogen refueling station is near completion and it is anticipated that construction will be complete in the fall of 1998. The vehicles are currently being refueled at a temporary refueling station. The diagnostic center is being designed and maintenance procedures as well as computer diagnostic programs for the fuel cell vehicles are being developed. City employees are driving the vehicles daily and monitoring data are being collected. The drivers are pleased with the performance of the vehicles.

  3. The Palm Desert Renewable Hydrogen Transportation System

    Energy Technology Data Exchange (ETDEWEB)

    Lehman, P. [Humboldt State Univ., Arcata, CA (United States)

    1996-10-01

    The present paper describes, for purposes of the Department of Energy (DoE) Hydrogen Program Review, Schatz Energy Research Center (SERC) progress on the Palm Desert Renewable Hydrogen Transportation System Project for the period January through June 1996. This period represents the first six months of the three year project. The estimated cost over three years is $3.9M, $1.859M of which is funded by the DoE ($600 k for fiscal year 1996). The goal of the Palm Desert Project is to develop a clean and sustainable transportation system for a community. The project will demonstrate the practical utility of hydrogen as a transportation fuel and proton exchange membrane (PEM) fuel cells as vehicle power plants. This transportation system will be developed in the City of Palm Desert in southern California and will include a fleet of 8 fuel cell powered vehicles, solar and wind powered hydrogen generating facilities, a consumer-ready refueling station, and a service infrastructure. The system holds the promise of a clean environment and an energy supply that is predictable, domestic, safe, and abundant. During, the first part of 1996 SERC has nearly completed building a fuel cell powered personal utility vehicle, which features an upgraded safety and computer system; they have designed and built a test bench that is able to mimic golf cart loads and test fuel cell system auxiliary components; they have begun the design of the solar hydrogen generating station; they have worked with Sandia National Laboratory on an advanced metal hydride storage system; they have increased the power density of the SERC fuel cell by as much as 50%; and they have reached out to the rest of the world with a new fact sheet, world wide web pages, a press release, video footage for a television program. and instruction within the community.

  4. Power Converters and Control of Renewable Energy Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Teodorescu, Remus; Chen, Zhe;

    2004-01-01

    The global electrical energy consumption is steadily rising and therefore a continuous demand to increase the power generation capacity. A significant percentage of the required capacity increase can be based on renewable energy sources. Wind turbine technology, as the most cost effective renewable...... energy conversion system, will play an important part in our future energy supply. But other sources like microturbines, photovoltaics and fuel cell systems may also be serious contributor to the power supply. Characteristically, power electronics will be an efficient and important interface to the grid...... for the renewables and this paper will first briefly discuss three different alternative/renewable energy sources. Next, various configurations of small and medium power conversion topologies are presented including their control (mainly for PV-systems). Finally wind turbine configuration and their control...

  5. Implementation of Renewable Energy Systems in Denmark

    DEFF Research Database (Denmark)

    Meyer, Niels I

    1997-01-01

    Denmark has been one of the first countries in the world to commit itself to a sustainable energy development. This has been substantiated by two official action plans from 1990 and 1996 with emphasis on energy efficiency and supply systems based on renewable energy. In year 2005, renewable energy...... sources are planned to cover 12-14% and in year 2030 about 35% of total Danish energy demand. This paper reviews the experiences with implementation of renewable energy in Denmark with a focus on wind power and biomass....

  6. The renewable electric plant information system

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, K.

    1995-12-01

    This report explains the procedures used for creating the Renewable Electric Plant Information System (REPiS) database, describes the database fields, and summarizes the data. The REPiS database contains comprehensive information on grid-connected renewable electric generation plants in the United States. Originally designed in 1987 and updated in 1990, the database includes information through 1994. The report also illustrates ways of using the data for analysis is and describes how researchers validated the data.

  7. Power electronics for renewable energy systems

    DEFF Research Database (Denmark)

    Iov, Florin; Blaabjerg, Frede

    2009-01-01

    sources from the conventional, fossil (and short term) based energy sources to renewable energy resources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss some of the most emerging renewable energy sources......, wind energy and photovoltaics, which by means of power electronics are changing from being minor energy sources to be acting as important power sources in the energy system....

  8. Career Directions--Renewable Energy Systems Integrator

    Science.gov (United States)

    Fleeman, Stephen R.

    2012-01-01

    Renewable energy systems are beginning to appear everywhere. Solar modules are creating "blue roofs" that convert the energy from the sun into household electricity. Solar thermal systems on roofs can generate hot water. Wind turbines catch breezes to provide even more electricity. Recommendations for saving energy, specifying systems for…

  9. Power electronics for renewable and distributed energy systems a sourcebook of topologies, control and integration

    CERN Document Server

    Chakraborty, Sudipta; Kramer, William E

    2013-01-01

    While most books approach power electronics and renewable energy as two separate subjects, Power Electronics for Renewable and Distributed Energy Systems takes an integrative approach; discussing power electronic converters topologies, controls and integration that are specific to the renewable and distributed energy system applications. An overview of power electronic technologies is followed by the introduction of various renewable and distributed energy resources that includes photovoltaics, wind, small hydroelectric, fuel cells, microturbines and variable speed generation. Energy storage s

  10. Renewable Electricity Generation via Solar-Powered Methanol Reforming: Hybrid Proton Exchange Membrane Fuel Cell Systems Based on Novel Non-Concentrating, Intermediate-Temperature Solar Collectors

    Science.gov (United States)

    Real, Daniel J.

    Tremendous research efforts have been conducted studying the capturing and conversion of solar energy. Solar thermal power systems offer a compelling opportunity for renewable energy utilization with high efficiencies and excellent cost-effectiveness. The goal of this work was to design a non-concentrating collector capable of reaching temperatures above 250 °C, use this collector to power methanol steam reforming, and operate a proton exchange membrane (PEM) fuel cell using the generated hydrogen. The study presents the construction and characterization of a non-concentrating, intermediate-temperature, fin-in-tube evacuated solar collector, made of copper and capable of reaching stagnation temperatures of 268.5 °C at 1000 W/m2 irradiance. The collector was used to power methanol steam reforming, including the initial heating and vaporization of liquid reactants and the final heating of the gaseous reactants. A preferential oxidation (PROX) catalyst was used to remove CO from simulated reformate gas, and this product gas was used to operate a PEM fuel cell. The results show 1) that the outlet temperature is not limited by heat transfer from the absorber coating to the heat transfer fluid, but by the amount of solar energy absorbed. This implicates a constant heat flux description of the heat transfer process and allows for the usage of materials with lower thermal conductivity than copper. 2) It is possible to operate a PEM fuel cell from reformate gas if a PROX catalyst is used to remove CO from the gas. 3) The performance of the fuel cell is only slightly decreased (~4%) by CO2 dilution present in the reformate and PROX gas. These results provide a foundation for the first renewable electricity generation via solar-powered methanol reforming through a hybrid PEM fuel cell system based on novel non-concentrating, intermediate-temperature solar collectors.

  11. Comparison between hybrid renewable energy systems in Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Hisham El Khashab

    2015-05-01

    This paper investigates RE sources applications at Yanbu, Saudi Arabia, besides a simulation using HOMER software to three proposed systems newly erected in Yanbu Industrial College Renewable Energy (RE lab. The lab represents a hybrid system, composed of PV, wind turbine, and Fuel cell systems. The cost of energy is compared in the three systems to have an actual estimation for RE in developing countries. The climatic variations at Yanbu that is located on the west coast of Saudi Arabia are considered.

  12. Electric vehicles and renewable energy in the transport sector - energy system consequences. Main focus: Battery electric vehicles and hydrogen based fuel cell vehicles

    DEFF Research Database (Denmark)

    Nielsen, L.H.; Jørgensen K.

    2000-01-01

    The aim of the project is to analyse energy, environmental and economic aspects of integrating electric vehicles in the future Danish energy system. Consequences of large-scale utilisation of electric vehicles are analysed. The aim is furthermore toillustrate the potential synergistic interplay...... between the utilisation of electric vehicles and large-scale utilisation of fluctuating renewable energy resources, such as wind power. Economic aspects for electric vehicles interacting with a liberalisedelectricity market are analysed. The project focuses on battery electric vehicles and fuel cell...... vehicles based on hydrogen. Based on assumptions on the future technical development for battery electric vehicles, fuel cell vehicles on hydrogen, and forthe conventional internal combustion engine vehicles, scenarios are set up to reflect expected options for the long-term development of road transport...

  13. Micro-financing of renewable energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Bunse, Maike; Wallbaum, Holger [triple innova (Germany); Dienst, Carmen [Wuppertal Inst. for Climate, Environment, Energy (Germany)

    2007-07-01

    While improved energy services have many quality of life benefits like lighting or television, the productive use of electricity can also help to reduce poverty, leading to increased profitability and productivity for micro, small and medium enterprises, and small industries. The remoteness of rural locations usually makes it difficult to expand electricity supply through a centralised grid system. Therefore people living in off-grid regions often rely on expensive fossil fuels like diesel and kerosene. People in remote areas often do not have the financial background to afford the initial costs for renewable energy applications. Micro-financing of renewable energy systems is a possible answer to provide financial services and support productive activities in a sustainable manner for low-income people. There are various types of microfinance institutions (MFIs), ranging from local cooperatives, NGOs, credit unions, private commercial banks and non-bank financial institutions as well as parts of state-owned banks.To underline the benefits of micro financing renewable energy systems, good practice projects of local microfinance activities are presented. These projects have been identified in the course of WISIONS, an initiative of the Wuppertal Inst. for Climate, Environment and Energy with support of ProEvolution, a Swiss-based foundation. The two different approaches of the project support on one side the realisation of new project ideas (SEPS - Sustainable Energy Project Support) and on the other spread successful examples (PREP - Promotion of Resource Efficiency Projects). Through the PREP field of action, good practices in energy and resource efficiency are spread worldwide through the Internet and brochures. In the 5th PREP-brochure of WISIONS on 'Microfinance and Renewable Energy' five good-practice examples are shown that link this promising financing system with modern and sustainable renewable energy technologies.

  14. Repeated batch cell-immobilized system for the biotechnological production of xylitol as a renewable green sweetener.

    Science.gov (United States)

    Sarrouh, Boutros; da Silva, Silvio Silvério

    2013-04-01

    The present paper studies the biotechnological production of xylitol using sugarcane bagasse hydrolysate in a repeated batch fermentation system with immobilized cells of Candida guilliermondii FTI20037. Immobilized cell system is considered as an attractive alternative to reuse the well-grown and adapted yeast cells in a new fresh fermentation media, without the need of the inoculum stage. In this work, seven repeated batches were performed in a fluidized bed bioreactor using immobilized cells in calcium alginate beads. According to the obtained results it was observed that the immobilized cells of C. guilliermondii can be reused for six successive batches maintaining an average xylitol yield (Y(p/s)) of 0.7 g/L and a volumetric productivity (Q(p)) of 0.42 g/Lh at the end of 432 h of fermentation. On the other hand, in the seventh batch (504 h), a decrease of 44 % in the final concentration of xylitol was observed. This reduction can be explained by the possible diffusion and accumulation of insoluble substances, found in the hemicellulosic hydrolysate, in the interior of the immobilization support resulting in substrate mass transfer limitations.

  15. Optimised Hybrid Integrated Renewable Energy System

    Directory of Open Access Journals (Sweden)

    Dr. Arun Sandilya

    2012-10-01

    Full Text Available A hybrid integrated renewable energy system for an isolated small community, where grid extension is considered uneconomical. This paper proposed cost optimization through dynamic matching between load and proper equipment sizing. The Matlab based computer program developed for determining the most cost effective energy source to supply required load any given time of the day. Integrated system based on green energy utilization and rural electricity development.

  16. Communication Systems for Grid Integration of Renewable Energy Resources

    CERN Document Server

    Yu, F Richard; Xiao, Weidong; Choudhury, Paul

    2011-01-01

    There is growing interest in renewable energy around the world. Since most renewable sources are intermittent in nature, it is a challenging task to integrate renewable energy resources into the power grid infrastructure. In this grid integration, communication systems are crucial technologies, which enable the accommodation of distributed renewable energy generation and play extremely important role in monitoring, operating, and protecting both renewable energy generators and power systems. In this paper, we review some communication technologies available for grid integration of renewable energy resources. Then, we present the communication systems used in a real renewable energy project, Bear Mountain Wind Farm (BMW) in British Columbia, Canada. In addition, we present the communication systems used in Photovoltaic Power Systems (PPS). Finally, we outline some research challenges and possible solutions about the communication systems for grid integration of renewable energy resources.

  17. Integrated electrofuels and renewable energy systems

    DEFF Research Database (Denmark)

    Ridjan, Iva

    energy into chemical energy by means of electrolysers, thus connecting fluctuating renewable energy to the vast amount of fuel storage already available in today’s energy systems. The conducted research indicates that electrofuels for heavy-duty transportation are technically and economically viable...... in energy systems and could play an important role in future energy systems. The cross-sector approach in the fuel production, by redirecting the excess electricity to the transport sector, is creating the flexibility and storage buffer for fluctuating electricity. The key concern in the short term should...

  18. Policies for 100% Renewable Energy Systems

    DEFF Research Database (Denmark)

    Hvelplund, Frede

    2014-01-01

    The official Danish energy policy goal is both to increase the wind power share of electricity consumption from 33% in 2014 to 50% by 2020 and to have a 100% renewable energy based energy system by 2050. This is a huge technological change from stored, scarce and polluting fossil fuels...... to fluctuating, abundant and clean energy sources. “Stored” fossil fuels can be used when needed; fluctuating energy sources must be captured when available and transformed to meet the energy needs of society in the right amounts and at the right time. We are amidst this change. Renewable energy has come of age...... and is no longer a minor technology experimenting in the corner of the energy scene, but has become a large new technology taking away considerable market shares from the old fossil fuel technologies....

  19. Response of Non-Linear Systems to Renewal Impulses by Path Integration

    DEFF Research Database (Denmark)

    Nielsen, Søren R.K.; Iwankiewicz, R.

    The cell-to-cell mapping (path integration) technique has been devised for MDOF non-linear and non-hysteretic systems subjected to random trains of impulses driven by an ordinary renewal point process with gamma-distributed integer parameter interarrival times (an Erlang process). Since the renew...

  20. Clonal, self-renewing and differentiating human and porcine urothelial cells, a novel stem cell population.

    Directory of Open Access Journals (Sweden)

    Hans M Larsson

    Full Text Available Although urothelial progenitor-like cells have been described in the human urinary tract, the existence of stem cells remains to be proven. Using a culture system that favors clonogenic epithelial cell growth, we evaluated and characterized clonal human urothelial cells. We isolated human urothelial cells that were clonogenic, capable of self-renewal and could develop into fully differentiated urothelium once re-implanted into the subcapsular space of nude mice. In addition to final urothelial cell differentiation, spontaneous formation of bladder-like microstructures was observed. By examining an epithelial stem cell signature marker, we found p63 to correlate with the self-renewal capacity of the isolated human urothelial clonal populations. Since a clinically relevant, long-term model for functional reconstitution of human cells does not exist, we sought to establish a culture method for porcine urothelial cells in a clinically relevant porcine model. We isolated cells from porcine ureter, urethra and bladder that were clonogenic and capable of self-renewal and differentiation into fully mature urothelium. In conclusion, we could isolate human and porcine cell populations, behaving as urothelial stem cells and showing clonogenicity, self-renewal and, once re-implanted, morphological differentiation.

  1. Integrated transport and renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Nørgaard, P.

    2008-01-01

    No single technology can solve the problem of ever increasing CO2 emissions from transport. Here, a coherent effort to integrate transport into energyplanning is proposed, using multiple means promoting sustainable transport. It is concluded that a 100 per cent renewable energy transport system...... is possible but is connected to significant challenges in the path towards it. Biomass is a limited resource and it is important to avoid effecting the production of food. The integration of the transport with the energy system is crucial as is a multi-pronged strategy. Short term solutions have to consider...

  2. The RenewElec Project: Variable Renewable Energy and the Power System

    Energy Technology Data Exchange (ETDEWEB)

    Apt, Jay

    2014-02-14

    Variable energy resources, such as wind power, now produce about 4% of U.S. electricity. They can play a significantly expanded role if the U.S. adopts a systems approach that considers affordability, security and reliability. Reaching a 20-30% renewable portfolio standard goal is possible, but not without changes in the management and regulation of the power system, including accurately assessing and preparing for the operational effects of renewable generation. The RenewElec project will help the nation make the transition to the use of significant amounts of electric generation from variable and intermittent sources of renewable power.

  3. Smart power systems and renewable energy system integration

    CERN Document Server

    2016-01-01

    This monograph presents a wider spectrum of researches, developments, and case specific studies in the area of smart power systems and integration of renewable energy systems. The book will be for the benefit of a wider audience including researchers, postgraduate students, practicing engineers, academics, and regulatory policy makers. It covers a wide range of topics from fundamentals, and modelling and simulation aspects of traditional and smart power systems to grid integration of renewables; Micro Grids; challenges in planning and operation of a smart power system; risks, security, and stability in smart operation of a power system; and applied research in energy storage. .

  4. Fuel Cell Power Plants Renewable and Waste Fuels

    Science.gov (United States)

    2011-01-13

    Fuel Cell Power Plants Renewable and Waste Fuels DOE-DOD Workshop Washington, DC. January 13, 2011 reliable, efficient, ultra-clean Report...2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Fuel Cell Power Plants Renewable and Waste Fuels 5a. CONTRACT...Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES presented at the DOE-DOD Waste-to-Energy using Fuel Cells Workshop held

  5. The system architecture for renewable synthetic fuels

    DEFF Research Database (Denmark)

    Ridjan, Iva

    To overcome and eventually eliminate the existing heavy fossil fuels in the transport sector, there is a need for new renewable fuels. This transition could lead to large capital costs for implementing the new solutions and a long time frame for establishing the new infrastructure unless a suitable...... infrastructure is present. The system integration of synthetic fuels will therefore depend on the existing infrastructure and the possibility of continuing its exploitation to minimize the costs and maximize the use of the current infrastructure in place. The production process includes different steps...... and production plants, so it is important to implement it in the best manner possible to ensure an efficient and flexible system. The poster will provide an overview of the steps involved in the production of synthetic fuel and possible solutions for the system architecture based on the current literature...

  6. Renewable Energy Laboratory for Lighting Systems

    CERN Document Server

    Cristian, Dumitru

    2010-01-01

    Nowadays, the electric lighting is an important part of our lives and also represents a significant part of the electric power consumption. Alternative solutions such as renewable energy applied in this domain are thus welcomed. This paper presents a workstation conceived for the study of photovoltaic solar energy for lighting systems by students of power engineering and civil engineering faculty. The proposed system is realized to study the generated photovoltaic solar energy parameters for lighting systems. For an easier way to study the most relevant parameters virtual instrumentation is implemented. National Instruments LabWindows CVI environment is used as a platform for virtual instrumentation. For future developments remote communication feature intends to be added on which currently remote monitoring of solar photovoltaic energy and electric energy parameters are monitored.

  7. Integrated transport and renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Nørgaard, Per

    2007-01-01

    transport. It is concluded that a 100 per cent renewable energy transport system is possible but is connected to significant challenges in the path towards it. Biomass is a limited resource and it is important to avoid effecting the production. The integration of the transport with the remaining energy....... No single technology can solve the problem of ever increasing CO2 emissions from transport. Transport must be integrated into energy planning, as electricity and heating. In this paper, a coherent effort to integrate transport into energy planning is proposed, using multiple means promoting sustainable...... system is crucial as is a multi-pronged strategy. Short term solutions have to consider the long term goal. In a short term proposal for 2030 it is concluded that it is possible both to reduce CO2 emissions substantially and, at the same time, gain socio-economic benefits. Biofuels is not able to solve...

  8. Self Renewal of Spermatogonial Stem Cells: the Most Promising Multipotent Cells - A Review

    Directory of Open Access Journals (Sweden)

    J. Tokas

    2011-10-01

    Full Text Available Germ cells are endowed with unique properties like the ability to undergo meiosis and differentiate into gametes in order to perpetuate the genetic material. Spermatogonial stem cells (SSC are considered as the best suited undifferentiated germ cells and are being consistently studied to reveal the basic physiology, genomics and transcriptomics of those cells. SSC provide an excellent model system to understand the differentiation, development and functioning of gonads and further use of these cells in transplantation-cell based therapies. In the present article, basic aspects of spermatogonial multiplication, regulation of stem cell renewal and differentiation would be discussed. [Vet. World 2011; 4(5.000: 234-240

  9. Epigenetic modifications and self-renewal regulation of mouse germline stem cells

    Institute of Scientific and Technical Information of China (English)

    Jiyoung Lee; Takashi Shinohara

    2011-01-01

    Germline stem (GS) cells were established from gonocytes and spermatogonia of postnatal mouse testes. GS cells proliferate in the presence of several kinds of cytokines, and a small percentage of GS cells also show spermatogonial stem cell (SSC) activity, i.e., they differentiate into sperm after being transplanted into infertile mouse testes without endogenous spermatogenesis. Interestingly, in GS cell culture, we also found that pluripotent stem cells (multipotent germline stem cells (mGS cells)) could be derived and these mGS cells do not have normal androgenetic genomic imprinting marks that are shown in GS cells, e.g., H19 hypermethylation. A new culture system for fetal male germ cells (embryonic GS (eGS) cells) has also been recently developed. Although these cells exhibited SSC potential, the offspring from cultured cells showed heritable imprinting defects in their DNA methylation patterns. In an attempt to understand the self-renewal machinery in SSCs, we transfected H-Ras and cylin D2 into GS cells, and successfully reconstructed the SSC self-renewal ability without using exogenous cytokines. Although these cells showed SSC activity in germ cell transplantation assays, we also found development of seminomatous tumors, possibly induced by excessive self-renewing signal. These stem cell culture systems are useful tools not only for understanding the mechanisms of self-renewal or epigenetic reprogramming but also for clarifying the mechanism of germ cell tumor development.

  10. Hematopoietic stem cells : Self-renewing or aging?

    NARCIS (Netherlands)

    de Haan, G

    2002-01-01

    Stem cells are defined by their extensive self-renewal properties, and yet there is abundant evidence of erosion of stem cell functioning during aging. Whereas intracellular repair and protection mechanisms determine the lifespan of an individual cell, here an argument is made that somatic stem cell

  11. Renewable energy systems the choice and modeling of 100% renewable solutions

    CERN Document Server

    Lund, Henrik

    2009-01-01

    How can society quickly convert to renewable energy? Can worldwide energy needs ever be met through 100% renewable sources? The answers to these questions rest largely on the perception of choice in the energy arena. It is of pivotal importance that engineers, researchers and policymakers understand what choices are available, and reasonable, when considering the design and deployment of new energy systems. The mission of this new book, written by one of the world's foremost experts in renewable power, is to arm these professionals with the tools and methodologies necessary to make smart choic

  12. Limiting biomass consumption for heating in 100% renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Connolly, David

    2012-01-01

    The utilisation of biomass poses large challenges in renewable energy systems while buildings account for a substantial part of the energy supply even in 100% renewable energy systems. In this paper the focus is on how the heating sector can reduce its consumption of biomass, thus leaving biomass...... for other sectors, but while still enabling a 100% renewable energy system. The analyses of heating technologies shows that district heating (DH) systems are important in limiting the dependence on biomass and create cost effective solutions. DH systems are especially important in renewable energy systems...... with large amounts of fluctuating sources as it enables fuel efficient and low cost energy systems with thermal heat storages. DH increases the efficiency with the use of combined heat and power production (CHP), while reducing the biomass demand by enabling the use of other renewable resources such as large...

  13. Electric vehicles and renewable energy in the transport sector - energy system consequences. Main focus: Battery electric vehicles and hydrogen based fuel cell vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, L.H.; Joergensen, K.

    2000-04-01

    The aim of the project is to analyse energy, environmental and economic aspects of integrating electric vehicles in the future Danish energy system. Consequences of large-scale utilisation of electric vehicles are analysed. The aim is furthermore to illustrate the potential synergistic interplay between the utilisation of electric vehicles and large-scale utilisation of fluctuating renewable energy resources, such as wind power. Economic aspects for electric vehicles interacting with a liberalised electricity market are analysed. The project focuses on battery electric vehicles and fuel cell vehicles based on hydrogen. Based on assumptions on the future technical development for battery electric vehicles, fuel cell vehicles on hydrogen, and for the conventional internal combustion engine vehicles, scenarios are set up to reflect expected options for the long-term development of road transport vehicles. Focus is put on the Danish fleet of passenger cars and delivery vans. The scenario analysis includes assumptions on market potential developments and market penetration for the alternative vehicles. Vehicle replacement rates in the Danish transport fleet and the size of fleet development are based on data from The Danish Road Directorate. The electricity supply system development assumed is based on the Danish energy plan, Energy 21, The Plan scenario. The time horizon of the analysis is year 2030. Results from the scenario analysis include the time scales involved for the potential transition towards electricity based vehicles, the fleet composition development, the associated developments in transport fuel consumption and fuel substitution, and the potential CO{sub 2}-emission reduction achievable in the overall transport and power supply system. Detailed model simulations, on an hourly basis, have furthermore been carried out for year 2005 that address potential electricity purchase options for electric vehicles in the context of a liberalised electricity market

  14. Muscle Satellite Cell Heterogeneity and Self-Renewal

    Directory of Open Access Journals (Sweden)

    Norio eMotohashi

    2014-01-01

    Full Text Available Adult skeletal muscle possesses extraordinary regeneration capacities. After muscle injury or exercise, large numbers of newly formed muscle fibers are generated within a week as a result of expansion and differentiation of a self-renewing pool of muscle stem cells termed muscle satellite cells. Normally, satellite cells are mitotically quiescent and reside beneath the basal lamina of muscle fibers. Upon regeneration, satellite cells are activated, and give rise to daughter myogenic precursor cells. After several rounds of proliferation, these myogenic precursor cells contribute to the formation of new muscle fibers. During cell division, a minor population of myogenic precursor cells returns to quiescent satellite cells as a self-renewal process. Currently, accumulating evidence has revealed the essential roles of satellite cells in muscle regeneration and the regulatory mechanisms, while it still remains to be elucidated how satellite cell self-renewal is molecularly regulated and how satellite cells are important in aging and diseased muscle. The number of satellite cells is decreased due to the changing niche during ageing, resulting in attenuation of muscle regeneration capacity. Additionally, in Duchenne muscular dystrophy (DMD patients, the loss of satellite cell regenerative capacity and decreased satellite cell number due to continuous needs for satellite cells lead to progressive muscle weakness with chronic degeneration. Thus, it is necessary to replenish muscle satellite cells continuously. This review outlines recent findings regarding satellite cell heterogeneity, asymmetric division and molecular mechanisms in satellite cell self-renewal which is crucial for maintenance of satellite cells as a muscle stem cell pool throughout life. In addition, we discuss roles in the stem cell niche for satellite cell maintenance, as well as related cell therapies for approaching treatment of DMD.

  15. Integration of Renewable Generation in Power System Defence Plans

    DEFF Research Database (Denmark)

    Das, Kaushik

    , one of them being the North East area with high share of wind power generation.The aim of this study is to investigate how renewable generations like wind power can contribute to the power system defence plans. This PhD project “Integration of Renewable Generation in Power System Defence Plans...

  16. Solid Oxide Fuel Cells Operating on Alternative and Renewable Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiaoxing; Quan, Wenying; Xiao, Jing; Peduzzi, Emanuela; Fujii, Mamoru; Sun, Funxia; Shalaby, Cigdem; Li, Yan; Xie, Chao; Ma, Xiaoliang; Johnson, David; Lee, Jeong; Fedkin, Mark; LaBarbera, Mark; Das, Debanjan; Thompson, David; Lvov, Serguei; Song, Chunshan

    2014-09-30

    This DOE project at the Pennsylvania State University (Penn State) initially involved Siemens Energy, Inc. to (1) develop new fuel processing approaches for using selected alternative and renewable fuels – anaerobic digester gas (ADG) and commercial diesel fuel (with 15 ppm sulfur) – in solid oxide fuel cell (SOFC) power generation systems; and (2) conduct integrated fuel processor – SOFC system tests to evaluate the performance of the fuel processors and overall systems. Siemens Energy Inc. was to provide SOFC system to Penn State for testing. The Siemens work was carried out at Siemens Energy Inc. in Pittsburgh, PA. The unexpected restructuring in Siemens organization, however, led to the elimination of the Siemens Stationary Fuel Cell Division within the company. Unfortunately, this led to the Siemens subcontract with Penn State ending on September 23rd, 2010. SOFC system was never delivered to Penn State. With the assistance of NETL project manager, the Penn State team has since developed a collaborative research with Delphi as the new subcontractor and this work involved the testing of a stack of planar solid oxide fuel cells from Delphi.

  17. Energy System Analysis of 100 Per cent Renewable Energy Systems

    DEFF Research Database (Denmark)

    Lund, Henrik; Mathiesen, Brian Vad

    2007-01-01

    the electricity supply and demand and to exchange electricity productions on the international electricity markets. The results are detailed system designs and energy balances for two energy target years: year 2050 with 100 per cent renewable energy from biomass and combinations of wind, wave and solar power...... of farming areas, or mostly on wind power, which will involve a large share of hydrogen or similar energy carriers leading to certain inefficiencies in the system design.......This paper presents the methodology and results of the overall energy system analysis of a 100 per cent renewable energy system. The input for the systems is the result of a project of the Danish Association of Engineers, in which 1600 participants during more than 40 seminars discussed...

  18. Renewable energy systems advanced conversion technologies and applications

    CERN Document Server

    Luo, Fang Lin

    2012-01-01

    Energy conversion techniques are key in power electronics and even more so in renewable energy source systems, which require a large number of converters. Renewable Energy Systems: Advanced Conversion Technologies and Applications describes advanced conversion technologies and provides design examples of converters and inverters for renewable energy systems-including wind turbine and solar panel energy systems. Learn Cutting-Edge Techniques for Converters and Inverters Setting the scene, the book begins with a review of the basics of astronomy and Earth physics. It then systematically introduc

  19. Integration of Renewable Generation in Power System Defence Plans

    OpenAIRE

    Das, Kaushik; Sørensen, Poul Ejnar; Anca Daniela HANSEN; Abildgaard, Hans

    2016-01-01

    Increasing levels of penetration of wind power and other renewable generations in European power systems pose challenges to power system security. The power system operators are continuously challenged especially when generations from renewables are high thereby reducing online capacity of conventional controllable generations to minimum. In such operation hours, the system is typically more vulnerable to disturbances in general and major disturbances in particular. This was the case in the m...

  20. Life-cycle analysis of renewable energy systems

    DEFF Research Database (Denmark)

    Sørensen, Bent

    1994-01-01

    An imlementation of life-cycle analysis (LCA) for energy systems is presented and applied to two renewable energy systems (wind turbines and building-integrated photovoltaic modules) and compared with coal plants......An imlementation of life-cycle analysis (LCA) for energy systems is presented and applied to two renewable energy systems (wind turbines and building-integrated photovoltaic modules) and compared with coal plants...

  1. Smart grid and renewable energy systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Guerrero, Josep M.

    2011-01-01

    The electrical energy consumption continues growing and more applications relay on electricity. We can expect that more 60 % of all energy consumption will be converted and used as electricity. Therefore, it is a demand that production, distribution and use of electrical energy are done as effici...... sources, wind energy and photovoltaics. Then main focus is on the power electronics and control technology for wind turbines as they are the largest renewable power contributor, allowing their penetration into a SmartGrid to be even higher in the future....... conventional, fossil based energy sources to renewable energy sources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discus trends of the future grid infrastructure as well as the most emerging renewable energy...

  2. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation

    NARCIS (Netherlands)

    Klauke, Karin; Radulovic, Visnja; Broekhuis, Mathilde; Weersing, Ellen; Zwart, Erik; Olthof, Sandra; Ritsema, Martha; Bruggeman, Sophia; Wu, Xudong; Helin, Kristian; Bystrykh, Leonid; de Haan, Gerald

    2013-01-01

    The balance between self-renewal and differentiation of adult stem cells is essential for tissue homeostasis. Here we show that in the haematopoietic system this process is governed by polycomb chromobox (Cbx) proteins. Cbx7 is specifically expressed in haematopoietic stem cells (HSCs), and its over

  3. Renewable energy systems in Mexico: Installation of a hybrid system

    Science.gov (United States)

    Pate, Ronald C.

    1993-05-01

    Sandia has been providing technical leadership on behalf of DOE and CORECT on a working level cooperative program with Mexico on renewable energy (PROCER). As part of this effort, the Sandia Design Assistance Center (DAC) and the solar energy program staff at Instituto de Investigaciones Electricas (IIE) in Cuernavaca, Mexico, recently reached agreement on a framework for mutually beneficial technical collaboration on the monitoring and field evaluation of renewable energy systems in Mexico, particularly village-scale hybrid systems. This trip was made for the purpose of planning the details for the joint installation of a data acquisition system (DAS) on a recently completed PV/Wind/Diesel hybrid system in the village of Xcalac on the Southeast coast of the state of Quintana Roo, Mexico. The DAS installation will be made during the week of March 15, 1993. While in Mexico, discussions were also held with personnel from.the National Autonomous University of Mexico (UNAM) Solar Energy Laboratory and several private sector companies with regard to renewable energy project activities and technical and educational support needs in Mexico.

  4. Soft computing in green and renewable energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Gopalakrishnan, Kasthurirangan [Iowa State Univ., Ames, IA (United States). Iowa Bioeconomy Inst.; US Department of Energy, Ames, IA (United States). Ames Lab; Kalogirou, Soteris [Cyprus Univ. of Technology, Limassol (Cyprus). Dept. of Mechanical Engineering and Materials Sciences and Engineering; Khaitan, Siddhartha Kumar (eds.) [Iowa State Univ. of Science and Technology, Ames, IA (United States). Dept. of Electrical Engineering and Computer Engineering

    2011-07-01

    Soft Computing in Green and Renewable Energy Systems provides a practical introduction to the application of soft computing techniques and hybrid intelligent systems for designing, modeling, characterizing, optimizing, forecasting, and performance prediction of green and renewable energy systems. Research is proceeding at jet speed on renewable energy (energy derived from natural resources such as sunlight, wind, tides, rain, geothermal heat, biomass, hydrogen, etc.) as policy makers, researchers, economists, and world agencies have joined forces in finding alternative sustainable energy solutions to current critical environmental, economic, and social issues. The innovative models, environmentally benign processes, data analytics, etc. employed in renewable energy systems are computationally-intensive, non-linear and complex as well as involve a high degree of uncertainty. Soft computing technologies, such as fuzzy sets and systems, neural science and systems, evolutionary algorithms and genetic programming, and machine learning, are ideal in handling the noise, imprecision, and uncertainty in the data, and yet achieve robust, low-cost solutions. As a result, intelligent and soft computing paradigms are finding increasing applications in the study of renewable energy systems. Researchers, practitioners, undergraduate and graduate students engaged in the study of renewable energy systems will find this book very useful. (orig.)

  5. Integrated Nuclear-Renewable Energy Systems: Foundational Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Bragg-Sitton, Shannon [Idaho National Lab. (INL), Idaho Falls, ID (United States); Boardman, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ruth, Mark [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zinaman, Owen [National Renewable Energy Lab. (NREL), Golden, CO (United States); Forsberg, Charles [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Collins, John [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-08-01

    The U.S. Department of Energy (DOE) recognizes the need to transform the energy infrastructure of the U.S. and elsewhere to systems that can drastically reduce environmental impacts in an efficient and economically viable manner while utilizing both hydrocarbon resources and clean energy generation sources. Thus, DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options. A concept being advanced by the DOE Offices of Nuclear Energy (NE) and Energy Efficiency and Renewable Energy (EERE) is tighter coupling of nuclear and renewable energy sources in a manner that produces new energy currency for the combined electricity grid, industrial manufacturing, and the transportation energy sectors. This integration concept has been referred to as a “hybrid system” that is capable of providing the right type of energy, at the right time, in the right place. At the direction of DOE-NE and DOE-EERE leadership, project leads at Idaho National Laboratory (INL), National Renewable Energy Laboratory (NREL) and Massachusetts Institute of Technology (MIT) have identified and engaged stakeholders in discussing integrated energy systems that would optimize renewable and nuclear energy integration on a region-by-region basis. Subsequent work will entail conduct of technical, economic, environmental and socio-political evaluations of the leading integrated system options based on a set of criteria established with stakeholder input. The Foundational Workshop for Integrated Nuclear – Renewable Energy Systems was organized around the following objectives: 1. Identify and refine priority region-specific opportunities for integrated nuclear-renewable energy systems in the U.S.; 2. Select Figures of Merit (FOM) to rank and prioritize candidate systems; 3. Discuss enabling technology development needs; 4. Identify analysis requirements, capabilities and gaps to estimate FOM for

  6. 100% Renewable energy systems, climate mitigation and economic growth

    DEFF Research Database (Denmark)

    Vad Mathiesen, Brian; Lund, Henrik; Karlsson, Kenneth Bernard

    2011-01-01

    that implementing energy savings, renewable energy and more efficient conversion technologies can have positive socio-economic effects, create employment and potentially lead to large earnings on exports. If externalities such as health effects are included, even more benefits can be expected. 100% Renewable energy...... systems will be technically possible in the future, and may even be economically beneficial compared to the business-as-usual energy system. Hence, the current debate between leaders should reflect a combination of these two main challenges....

  7. Stem cell concepts renew cancer research.

    Science.gov (United States)

    Dick, John E

    2008-12-15

    Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the individual cells that make up the tumor exhibit considerable variation in many properties, including morphology, proliferation kinetics, and the ability to initiate tumor growth in transplant assays. Understanding the molecular and cellular basis of this heterogeneity has important implications in the design of therapeutic strategies. The mechanistic basis of tumor heterogeneity has been uncertain; however, there is now strong evidence that cancer is a cellular hierarchy with cancer stem cells at the apex. This review provides a historical overview of the influence of hematology on the development of stem cell concepts and their linkage to cancer.

  8. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation

    DEFF Research Database (Denmark)

    Klauke, Karin; Radulović, Višnja; Broekhuis, Mathilde;

    2013-01-01

    The balance between self-renewal and differentiation of adult stem cells is essential for tissue homeostasis. Here we show that in the haematopoietic system this process is governed by polycomb chromobox (Cbx) proteins. Cbx7 is specifically expressed in haematopoietic stem cells (HSCs), and its......7 and Cbx8 share most of their targets; we identified approximately 200 differential targets. Whereas genes targeted by Cbx8 are highly expressed in HSCs and become repressed in progenitors, Cbx7 targets show the opposite expression pattern. Thus, Cbx7 preserves HSC self-renewal by repressing...

  9. International Conference on Power Electronics and Renewable Energy Systems

    CERN Document Server

    Suresh, L; Dash, Subhransu; Panigrahi, Bijaya

    2015-01-01

    The book is a collection of high-quality peer-reviewed research papers presented in Proceedings of International Conference on Power Electronics and Renewable Energy Systems (ICPERES 2014) held at Rajalakshmi Engineering College, Chennai, India. These research papers provide the latest developments in the broad area of Power Electronics and Renewable Energy. The book discusses wide variety of industrial, engineering and scientific applications of the emerging techniques. It presents invited papers from the inventors/originators of new applications and advanced technologies.

  10. Renewable sustainable biocatalyzed electricity production in a photosynthetic algal microbial fuel cell (PAMFC)

    NARCIS (Netherlands)

    Strik, D.P.B.T.B.; Terlouw, H.; Hamelers, H.V.M.; Buisman, C.J.N.

    2008-01-01

    Electricity production via solar energy capturing by living higher plants and microalgae in combination with microbial fuel cells are attractive because these systems promise to generate useful energy in a renewable, sustainable, and efficient manner. This study describes the proof of principle of a

  11. The Potential of Renewable Energy Systems in China

    DEFF Research Database (Denmark)

    Liu, Wen; Lund, Henrik; Mathiesen, Brian Vad

    2009-01-01

    This paper discusses the prospective of renewable energy in the process of sustainable development in China. Along with the high-speed economic development and increasing energy consumption, the Chinese Government faces a growing pressure to maintain the balance between energy supply and demand....... Such sustainable energy strategy typical involves three technologies issue: energy conservation, efficiency improvement and replacement fossil fuel by renewable energy sources. Denmark is an example of such strategy can be implemented and it shows the possibility of converting into a 100% renewable energy system...... as well as reduce environmental pollution. To ensure energy security and mitigate climate changes the inappropriate energy consumption structure should be changed. As an alternative, a suitable infrastructure for the implementation of renewable energy may serve as a long-term sustainable possibility...

  12. Management of a power system based on renewable energy

    Directory of Open Access Journals (Sweden)

    Ronay Karoly

    2012-06-01

    Full Text Available This article main purpose is to highlight the main advantage of the hardware and software implementation for an energy management system based on renewable energy sources. By using implemented and dedicated hardware and software the evolution of energy production and consumption can be monitored. The advantages of such system are highlighted by the results obtained from experimental simulations. An experimental model for the power system based on renewable energy sources was implemented, where the actual status of the system in different situations when the equipments change their own statuses can be shown.

  13. Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells

    Science.gov (United States)

    Shen, Qin; Goderie, Susan K.; Jin, Li; Karanth, Nithin; Sun, Yu; Abramova, Natalia; Vincent, Peter; Pumiglia, Kevin; Temple, Sally

    2004-05-01

    Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche.

  14. 100% Renewable Energy Systems in Project Future Climate

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad

    2009-01-01

    , create employment and potentially lead to large earnings on exports. If externalities such as health effects etc. are included, even more benefits can be expected. 100 per cent renewable energy systems will be technically possible in the future, and may even be economically beneficial compared...... energy system by the year 2050 are presented. Two short term transition target years in the process towards this goal are analysed for 2015 and 2030. The analyses reveal that implementing energy savings, renewable energy and more efficient conversion technologies can have positive socioeconomic effects...... to the business-as-usual energy system. Hence the current debate between leaders should reflect a combination of these two main challenges....

  15. Power Electronics and Reliability in Renewable Energy Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Ma, Ke; Zhou, Dao

    2012-01-01

    Power Electronics are needed in almost all kind of renewable energy systems. It is used both for controlling the renewable source and also for interfacing to the load, which can be grid-connected or working in stand-alone mode. More and more efforts are put into making renewable energy systems...... better in terms of reliability in order to ensure a high availability of the power sources, in this case the knowledge of mission profile of a certain application is crucial for the reliability evaluation/design of power electronics. In this paper an overview on the power electronic circuits behind...... the most common converter configurations for wind turbine and photovoltaic is done. Next different aspects of improving the system reliability are mapped. Further on examples of how to control the chip temperature in different power electronic configurations as well as operation modes for wind power...

  16. WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics

    Institute of Scientific and Technical Information of China (English)

    Isabelle Bisson; David M Prowse

    2009-01-01

    Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their abil-ity to form from single cells self-renewing prostaspheres in non-adherent cultures. Prostaspheres exhibited heteroge-neous expression of proliferation, differentiation and stem cell-associated makers CD44, ABCG2 and CD133. Treat-ment with WNT inhibitors reduced both prostasphere size and self-renewal, In contrast, addition of Wnt3a caused increased prostasphere size and self-renewal, which was associated with a significant increase in nuclear β-catenin, keratin 18, CD133 and CD44 expression. As a high proportion of LNCaP and C4-2B cancer cells express androgen receptor we determined the effect of the androgen receptor antagonist bicalutamide. Androgen receptor inhibition reduced prostasphere size and expression of PSA, but did not inhibit prostasphere formation. These effects are con-sistent with the androgen-independent self-renewal of cells with stem cell characteristics and the androgen-dependent proliferation of transit amplifying cells. As the canonical WNT signaling effector β-catenin can also associate with the androgen receptor, we propose a model for tumour propagation involving a balance between WNT and androgen re-ceptor activity. That would affect the self-renewal of a cancer cell with stem cell characteristics and drive transit am-plifying cell proliferation and differentiation. In conclusion, we provide evidence that WNT activity regulates the self-renewal of prostate cancer cells with stem cell characteristics independently of androgen receptor activity. Inhibition of WNT signaling therefore has the potential to reduce the self-renewal of prostate cancer cells with stem cell charac-teristics and improve the therapeutic outcome.

  17. EVermont Renewable Hydrogen Production and Transportation Fueling System

    Energy Technology Data Exchange (ETDEWEB)

    Garabedian, Harold T.

    2008-03-30

    A great deal of research funding is being devoted to the use of hydrogen for transportation fuel, particularly in the development of fuel cell vehicles. When this research bears fruit in the form of consumer-ready vehicles, will the fueling infrastructure be ready? Will the required fueling systems work in cold climates as well as they do in warm areas? Will we be sure that production of hydrogen as the energy carrier of choice for our transit system is the most energy efficient and environmentally friendly option? Will consumers understand this fuel and how to handle it? Those are questions addressed by the EVermont Wind to Wheels Hydrogen Project: Sustainable Transportation. The hydrogen fueling infrastructure consists of three primary subcomponents: a hydrogen generator (electrolyzer), a compression and storage system, and a dispenser. The generated fuel is then used to provide transportation as a motor fuel. EVermont Inc., started in 1993 by then governor Howard Dean, is a public-private partnership of entities interested in documenting and advancing the performance of advanced technology vehicles that are sustainable and less burdensome on the environment, especially in areas of cold climates, hilly terrain and with rural settlement patterns. EVermont has developed a demonstration wind powered hydrogen fuel producing filling system that uses electrolysis, compression to 5000 psi and a hydrogen burning vehicle that functions reliably in cold climates. And that fuel is then used to meet transportation needs in a hybrid electric vehicle whose internal combustion engine has been converted to operate on hydrogen Sponsored by the DOE EERE Hydrogen, Fuel Cells & Infrastructure Technologies (HFC&IT) Program, the purpose of the project is to test the viability of sustainably produced hydrogen for use as a transportation fuel in a cold climate with hilly terrain and rural settlement patterns. Specifically, the project addresses the challenge of building a renewable

  18. The feasibility of synthetic fuels in renewable energy systems

    DEFF Research Database (Denmark)

    Ridjan, Iva; Mathiesen, Brian Vad; Connolly, D.

    2013-01-01

    , and other impacts on the environment and biosphere. Hence, it is essential to make a detailed analysis of this sector in order to match the demand and to meet the criteria of a 100% renewable energy system in 2050. The purpose of this article is to identify potential pathways for producing synthetic fuels......While all other sectors had significant renewable energy penetrations, transport is still heavily dependent on oil displaying rapid growth in the last decades. There is no easy renewable solution to meet transport sector demand due to the wide variety of modes and needs in the sector. Nowadays......, biofuels along with electricity are proposed as one of the main options for replacing fossil fuels in the transport sector. The main reasons for avoiding the direct usage of biomass, i.e. producing biomass derived fuels, are land use shortages, limited biomass availability, interference with food supplies...

  19. Design for Reliability of Power Electronics in Renewable Energy Systems

    DEFF Research Database (Denmark)

    Ma, Ke; Yang, Yongheng; Wang, Huai

    2014-01-01

    Power electronics is the enabling technology for maximizing the power captured from renewable electrical generation, e.g., the wind and solar technology, and also for an efficient integration into the grid. Therefore, it is important that the power electronics are reliable and do not have too many...... electronics technology as well as to know how the power electronics technology is loaded in terms of temperature and other stressors relevant, to reliability. Hence, this chapter will show the basics of power electronics technology for renewable energy systems, describe the mission profile of the technology...... failures during operation which otherwise will increase cost for operation, maintenance and reputation. Typically, power electronics in renewable electrical generation has to be designed for 20–30 years of operation, and in order to do that, it is crucial to know about the mission profile of the power...

  20. Nuclear-Renewable Hybrid Energy System Market Analysis Plans

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Mark

    2016-06-09

    This presentation describes nuclear-renewable hybrid energy systems (N-R HESs), states their potential benefits, provides figures for the four tightly coupled N-R HESs that NREL is currently analyzing, and outlines the analysis process that is underway.

  1. Foundations for Protecting Renewable-Rich Distribution Systems.

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, Abraham [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Brahma, Sukumar [New Mexico State Univ., Las Cruces, NM (United States); Ranade, Satish [New Mexico State Univ., Las Cruces, NM (United States)

    2016-11-01

    High proliferation of Inverter Interfaced Distributed Energy Resources (IIDERs) into the electric distribution grid introduces new challenges to protection of such systems. This is because the existing protection systems are designed with two assumptions: 1) system is single-sourced, resulting in unidirectional fault current, and (2) fault currents are easily detectable due to much higher magnitudes compared to load currents. Due to the fact that most renewables interface with the grid though inverters, and inverters restrict their current output to levels close to the full load currents, both these assumptions are no longer valid - the system becomes multi-sourced, and overcurrent-based protection does not work. The primary scope of this study is to analyze the response of a grid-tied inverter to different faults in the grid, leading to new guidelines on protecting renewable-rich distribution systems.

  2. Vaginal epithelial dendritic cells renew from bone marrow precursors.

    Science.gov (United States)

    Iijima, Norifumi; Linehan, Melissa M; Saeland, Sem; Iwasaki, Akiko

    2007-11-27

    Dendritic cells (DCs) represent key professional antigen-presenting cells capable of initiating primary immune responses. A specialized subset of DCs, the Langerhans cells (LCs), are located in the stratified squamous epithelial layer of the skin and within the mucosal epithelial lining of the vaginal and oral cavities. The vaginal mucosa undergoes cyclic changes under the control of sex hormones, and the renewal characteristics of the vaginal epithelial DCs (VEDCs) remain unknown. Here, we examined the origin of VEDCs. In contrast to the skin epidermal LCs, the DCs in the epithelium of the vagina were found to be repopulated mainly by nonmonocyte bone-marrow-derived precursors, with a half-life of 13 days under steady-state conditions. Upon infection with HSV-2, the Gr-1(hi) monocytes were found to give rise to VEDCs. Furthermore, flow cytometric analysis of the VEDCs revealed the presence of at least three distinct populations, namely, CD11b(+)F4/80(hi), CD11b(+)F4/80(int), and CD11b(-)F4/80(-). Importantly, these VEDC populations expressed CD207 at low levels and had a constitutively more activated phenotype compared with the skin LCs. Collectively, our results revealed mucosa-specific features of the VEDCs with respect to their phenotype, activation status, and homeostatic renewal potential.

  3. Risk management of non-renewable energy systems

    CERN Document Server

    Verma, Ajit Kumar; Muruva, Hari Prasad

    2015-01-01

    This book describes the basic concepts of risk and reliability with detailed descriptions of the different levels of probabilistic safety assessment of nuclear power plants (both internal and external). The book also maximizes readers insights into time dependent risk analysis through several case studies, whilst risk management with respect to non renewable energy sources is also explained. With several advanced reactors utilizing the concept of passive systems, the reliability estimation of these systems are explained in detail with the book providing a reliability estimation of components through mechanistic model approach. This book is useful for advanced undergraduate and post graduate students in nuclear engineering, aerospace engineering, industrial engineering, reliability and safety engineering, systems engineering and applied probability and statistics. This book is also suitable for one-semester graduate courses on risk management of non renewable energy systems in all conventional engineering bran...

  4. Electrical Energy Storage for Renewable Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Helms, C. R. [Univ. of Texas, Dallas, TX (United States); Cho, K. J. [Univ. of Texas, Dallas, TX (United States); Ferraris, John [Univ. of Texas, Dallas, TX (United States); Balkus, Ken [Univ. of Texas, Dallas, TX (United States); Chabal, Yves [Univ. of Texas, Dallas, TX (United States); Gnade, Bruce [Univ. of Texas, Dallas, TX (United States); Rotea, Mario [Univ. of Texas, Dallas, TX (United States); Vasselli, John [Univ. of Texas, Dallas, TX (United States)

    2012-08-31

    This program focused on development of the fundamental understanding necessary to significantly improve advanced battery and ultra-capacitor materials and systems to achieve significantly higher power and energy density on the one hand, and significantly lower cost on the other. This program spanned all the way from atomic-level theory, to new nanomaterials syntheses and characterization, to system modeling and bench-scale technology demonstration. This program not only delivered significant advancements in fundamental understanding and new materials and technology, it also showcased the power of the cross-functional, multi-disciplinary teams at UT Dallas and UT Tyler for such work. These teams are continuing this work with other sources of funding from both industry and government.

  5. Pressure retarded osmosis as a controlling system for traditional renewables

    Science.gov (United States)

    Carravetta, Armando; Fecarotta, Oreste; La Rocca, Michele; Martino, Riccardo

    2015-04-01

    Pressure retarded osmosis (PRO) is a viable but still not diffused form of renewable energy (see Maisonneuve et al., 2015 for a recent literature review). In PRO, water from a low salinity feed solution permeates through a membrane into a pressurized, high salinity draw solution, giving rise to a positive pressure drop; then energy is obtained by depressurizing the permeate through a hydro-turbine and brackish water is discharged. Many technological, environmental and economical aspects are obstacles in the diffusion of PRO, like the vulnerability of the membranes to fouling, the impact of the brackish water on the local marine environment, the high cost of membranes, etc. We are interested in the use of PRO as a combined form of energy with other renewable energy source like solar, wind or mini hydro in water supply networks (WSN). For the wide diffusion of renewables one of the major concerns of commercial power companies is to obtain very stable form of energy to comply with prescriptions of electricity grid operators and with the instant energy demand curve. Renewables are generally very variable form of energy, for the influence of climatic conditions on available power, and of the fluctuation in water demand in WSN. PRO is a very flexible technology where with appropriate turbines and control system power can be varied continuously to compensate for variation of other source of energy. Therefore, PRO is suitable to be used as a balancing system for commercial power system. We will present a simulation of the performance of a PRO used in combination with three different renewables. In the first two scenarios PRO compensate the difference between energy demand and energy production of a solar power plant and hydro power plant in a WSN. In the third scenario PRO is used to compensate daily variation of energy production in a wind power plant. Standard curves of energy production and energy demand for southern Italy are used. In order to control PRO production an

  6. 100% Renewable energy systems, climate mitigation and economic growth

    Energy Technology Data Exchange (ETDEWEB)

    Mathiesen, Brian Vad; Lund, Henrik [Department of Development and Planning, Aalborg University (Denmark); Karlsson, Kenneth [Risoe National Laboratory for Sustainable Energy, Technical University of Denmark (Denmark)

    2011-02-15

    Greenhouse gas mitigation strategies are generally considered costly with world leaders often engaging in debate concerning the costs of mitigation and the distribution of these costs between different countries. In this paper, the analyses and results of the design of a 100% renewable energy system by the year 2050 are presented for a complete energy system including transport. Two short-term transition target years in the process towards this goal are analysed for 2015 and 2030. The energy systems are analysed and designed with hour-by-hour energy system analyses. The analyses reveal that implementing energy savings, renewable energy and more efficient conversion technologies can have positive socio-economic effects, create employment and potentially lead to large earnings on exports. If externalities such as health effects are included, even more benefits can be expected. 100% Renewable energy systems will be technically possible in the future, and may even be economically beneficial compared to the business-as-usual energy system. Hence, the current debate between leaders should reflect a combination of these two main challenges. (author)

  7. The role of district heating in future renewable energy systems

    DEFF Research Database (Denmark)

    Lund, Henrik; Möller, Bernd; Mathiesen, Brian Vad

    2010-01-01

    Based on the case of Denmark, this paper analyses the role of district heating in future Renewable Energy Systems. At present, the share of renewable energy is coming close to 20 per cent. From such point of departure, the paper defines a scenario framework in which the Danish system is converted...... heating options, including district heating as well as individual heat pumps and micro CHPs (Combined Heat and Power). The study includes almost 25 per cent of the Danish building stock, namely those buildings which have individual gas or oil boilers today and could be substituted by district heating...... or a more efficient individual heat source. In such overall perspective, the best solution will be to combine a gradual expansion of district heating with individual heat pumps in the remaining houses. Such conclusion is valid in the present systems, which are mainly based on fossil fuels, as well...

  8. Tribological design constraints of marine renewable energy systems.

    Science.gov (United States)

    Wood, Robert J K; Bahaj, AbuBakr S; Turnock, Stephen R; Wang, Ling; Evans, Martin

    2010-10-28

    Against the backdrop of increasing energy demands, the threat of climate change and dwindling fuel reserves, finding reliable, diverse, sustainable/renewable, affordable energy resources has become a priority for many countries. Marine energy conversion systems are at the forefront of providing such a resource. Most marine renewable energy conversion systems require tribological components to convert wind or tidal streams to rotational motion for generating electricity while wave machines typically use oscillating hinge or piston within cylinder geometries to promote reciprocating linear motion. This paper looks at the tribology of three green marine energy systems, offshore wind, tidal and wave machines. Areas covered include lubrication and contamination, bearing and gearbox issues, biofouling, cavitation erosion, tribocorrosion, condition monitoring as well as design trends and loading conditions associated with tribological components. Current research thrusts are highlighted along with areas needing research as well as addressing present-day issues related to the tribology of offshore energy conversion technologies.

  9. Power electronics - The key technology for Renewable Energy Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Ma, Ke; Yang, Yongheng

    2014-01-01

    and effectively, energy conversion systems, currently based on power electronics technology, will again play an essential role in this energy paradigm shift. Using highly efficient power electronics in power generation, power transmission/distribution and end-user application, together with advanced control...... solutions, can pave the way for renewable energies. In light of this, some of the most emerging renewable energies, e.g. wind energy and photovoltaic, which by means of power electronics are changing character as a major part in the electricity generation, are explored in this paper. Issues like technology...... development, implementation, power converter technologies, control of the systems, and synchronization are addressed. Special focuses are paid on the future trends in power electronics for those systems like how to lower the cost of energy and to develop emerging power devices and better reliability tool....

  10. Electrical Energy Storage for Renewable Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Helms, C. R.; Cho, K. J.; Ferraris, John; Balkus, Ken; Chabal, Yves; Gnade, Bruce; Rotea, Mario; Vasselli, John

    2012-08-31

    This program focused on development of the fundamental understanding necessary to significantly improve advanced battery and ultra-capacitor materials and systems to achieve significantly higher power and energy density on the one hand, and significantly lower cost on the other. This program spanned all the way from atomic-level theory, to new nanomaterials syntheses and characterization, to system modeling and bench-scale technology demonstration. Significant accomplishments are detailed in each section. Those particularly noteworthy include: • Transition metal silicate cathodes with 2x higher storage capacity than commercial cobalt oxide cathodes were demonstrated. • MnO₂ nanowires, which are a promising replacement for RuO₂, were synthesized • PAN-based carbon nanofibers were prepared and characterized with an energy density 30-times higher than current ultracapacitors on the market and comparable to lead-acid batteries • An optimization-based control strategy for real-time power management of battery storage in wind farms was developed and demonstrated. • PVDF films were developed with breakdown strengths of > 600MVm⁻¹, a maximum energy density of approximately 15 Jcm⁻³, and an average dielectric constant of 9.8 (±1.2). Capacitors made from these films can support a 10-year lifetime operating at an electric field of 200 MV m⁻¹. This program not only delivered significant advancements in fundamental understanding and new materials and technology, it also showcased the power of the cross-functional, multi-disciplinary teams at UT Dallas and UT Tyler for such work. These teams are continuing this work with other sources of funding from both industry and government.

  11. Renewable energy for sustainable electrical energy system in India

    Energy Technology Data Exchange (ETDEWEB)

    Mallah, Subhash; Bansal, N.K. [Shri Mata Vaishno Devi University, Katra 182320, Jammu and Kashmir (India)

    2010-08-15

    Present trends of electrical energy supply and demand are not sustainable because of the huge gap between demand and supply in foreseeable future in India. The path towards sustainability is exploitation of energy conservation and aggressive use of renewable energy systems. Potential of renewable energy technologies that can be effectively harnessed would depend on future technology developments and breakthrough in cost reduction. This requires adequate policy guidelines and interventions in the Indian power sector. Detailed MARKAL simulations, for power sector in India, show that full exploitation of energy conservation potential and an aggressive implementation of renewable energy technologies lead to sustainable development. Coal and other fossil fuel (gas and oil) allocations stagnated after the year 2015 and remain constant up to 2040. After the year 2040, the requirement for coal and gas goes down and carbon emissions decrease steeply. By the year 2045, 25% electrical energy can be supplied by renewable energy and the CO{sub 2} emissions can be reduced by 72% as compared to the base case scenario. (author)

  12. Design of smart power grid renewable energy systems

    CERN Document Server

    Keyhani, Ali

    2011-01-01

    To address the modeling and control of smart grid renewable energy system into electric power systems, this book integrates three areas of electrical engineering: power system engineering, control systems engineering and power electronics  The approach to the integration of these three areas differs from classical methods. Due to complexity of this task, the author has decided to present the basic concepts, and then present a simulation test bed in matlab to use these concepts to solve a basic problem in development of smart grid energy system. Therefore, each chapter has three parts: first a

  13. Technoeconomic analysis of renewable hydrogen production, storage, and detection systems

    Energy Technology Data Exchange (ETDEWEB)

    Mann, M.K.; Spath, P.L.; Kadam, K. [National Renewable Energy Lab., Golden, CO (United States)

    1996-10-01

    Technical and economic feasibility studies of different degrees of completeness and detail have been performed on several projects being funded by the Department of Energy`s Hydrogen Program. Work this year focused on projects at the National Renewable Energy Laboratory, although analyses of projects at other institutions are underway or planned. Highly detailed analyses were completed on a fiber optic hydrogen leak detector and a process to produce hydrogen from biomass via pyrolysis followed by steam reforming of the pyrolysis oil. Less detailed economic assessments of solar and biologically-based hydrogen production processes have been performed and focused on the steps that need to be taken to improve the competitive position of these technologies. Sensitivity analyses were conducted on all analyses to reveal the degree to which the cost results are affected by market changes and technological advances. For hydrogen storage by carbon nanotubes, a survey of the competing storage technologies was made in order to set a baseline for cost goals. A determination of the likelihood of commercialization was made for nearly all systems examined. Hydrogen from biomass via pyrolysis and steam reforming was found to have significant economic potential if a coproduct option could be co-commercialized. Photoelectrochemical hydrogen production may have economic potential, but only if low-cost cells can be modified to split water and to avoid surface oxidation. The use of bacteria to convert the carbon monoxide in biomass syngas to hydrogen was found to be slightly more expensive than the high end of currently commercial hydrogen, although there are significant opportunities to reduce costs. Finally, the cost of installing a fiber-optic chemochromic hydrogen detection system in passenger vehicles was found to be very low and competitive with alternative sensor systems.

  14. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation.

    Science.gov (United States)

    Klauke, Karin; Radulović, Višnja; Broekhuis, Mathilde; Weersing, Ellen; Zwart, Erik; Olthof, Sandra; Ritsema, Martha; Bruggeman, Sophia; Wu, Xudong; Helin, Kristian; Bystrykh, Leonid; de Haan, Gerald

    2013-04-01

    The balance between self-renewal and differentiation of adult stem cells is essential for tissue homeostasis. Here we show that in the haematopoietic system this process is governed by polycomb chromobox (Cbx) proteins. Cbx7 is specifically expressed in haematopoietic stem cells (HSCs), and its overexpression enhances self-renewal and induces leukaemia. This effect is dependent on integration into polycomb repressive complex-1 (PRC1) and requires H3K27me3 binding. In contrast, overexpression of Cbx2, Cbx4 or Cbx8 results in differentiation and exhaustion of HSCs. ChIP-sequencing analysis shows that Cbx7 and Cbx8 share most of their targets; we identified approximately 200 differential targets. Whereas genes targeted by Cbx8 are highly expressed in HSCs and become repressed in progenitors, Cbx7 targets show the opposite expression pattern. Thus, Cbx7 preserves HSC self-renewal by repressing progenitor-specific genes. Taken together, the presence of distinct Cbx proteins confers target selectivity to PRC1 and provides a molecular balance between self-renewal and differentiation of HSCs.

  15. Design, analysis, operation, and advanced control of hybrid renewable energy systems

    Science.gov (United States)

    Whiteman, Zachary S.

    Because using non-renewable energy systems (e.g., coal-powered co-generation power plants) to generate electricity is an unsustainable, environmentally hazardous practice, it is important to develop cost-effective and reliable renewable energy systems, such as photovoltaics (PVs), wind turbines (WTs), and fuel cells (FCs). Non-renewable energy systems, however, are currently less expensive than individual renewable energy systems (IRESs). Furthermore, IRESs based on intermittent natural resources (e.g., solar irradiance and wind) are incapable of meeting continuous energy demands. Such shortcomings can be mitigated by judiciously combining two or more complementary IRESs to form a hybrid renewable energy system (HRES). Although previous research efforts focused on the design, operation, and control of HRESs has proven useful, no prior HRES research endeavor has taken a systematic and comprehensive approach towards establishing guidelines by which HRESs should be designed, operated, and controlled. The overall goal of this dissertation, therefore, is to establish the principles governing the design, operation, and control of HRESs resulting in cost-effective and reliable energy solutions for stationary and mobile applications. To achieve this goal, we developed and demonstrated four separate HRES principles. Rational selection of HRES type: HRES components and their sizes should be rationally selected using knowledge of component costs, availability of renewable energy resources, and expected power demands of the application. HRES design: by default, the components of a HRES should be arranged in parallel for increased efficiency and reliability. However, a series HRES design may be preferred depending on the operational considerations of the HRES components. HRES control strategy selection: the choice of HRES control strategy depends on the dynamics of HRES components, their operational considerations, and the practical limitations of the HRES end-use. HRES data

  16. Power Electronics for Renewable Energy Systems - Status and Trends

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Ma, Ke; Yang, Yongheng

    2014-01-01

    electronics in generation, transmission/distribution and end-user application, together with advanced controls, can pave the way for renewable energy resources. In view of this, some of the most promising renewable candidates like wind power and photovoltaic, which are becoming a significant part...... in the electricity production, are explored in this paper. Issues like technology demands, power converter topologies, and control structures are addressed. Some special focuses are also paid on the emerging trends in power electronics development for those systems....... and use of the energy to be as technological efficient as possible, and incentives to save energy at the end-user should also be strengthened. In order to realize the transition smoothly and effectively, power conversion systems will continue to play an essential role. Using highly efficient power...

  17. Rethinking the Future Grid: Integrated Nuclear Renewable Energy Systems: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Bragg-Sitton, S. M.; Boardman, R.; Ruth, M.; Zinaman, O.; Forsberg, C.

    2015-01-01

    The U.S. DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options, to meet both grid demand and thermal energy needs in the industrial sector. One concept under consideration by the DOE-NE and DOE-EERE is tighter coupling of nuclear and renewable energy sources in a manner that better optimizes energy use for the combined electricity, industrial manufacturing, and transportation sectors. This integration concept has been referred to as a 'hybrid system' that is capable of apportioning thermal and electrical energy to first meet the grid demand (with appropriate power conversion systems), then utilizing excess thermal and, in some cases, electrical energy to drive a process that results in an additional product.

  18. Power System Transformation toward Renewables: Investment Scenarios for Germany

    OpenAIRE

    2014-01-01

    We analyze distinctive investment scenarios for the integration of fluctuating renewables in the German power system. Using a combined model for dispatch, transmission, and investment, three different investment options are considered, including gas-fired power plants, pumped hydro storage, and transmission lines. We find that geographically optimized power plant investments dominate in the reference scenarios for 2024 and 2034. In scenarios with decreasedrenewable curtailment, storage and tr...

  19. Photoactivated Fuel Cells (PhotoFuelCells. An alternative source of renewable energy with environmental benefits

    Directory of Open Access Journals (Sweden)

    Stavroula Sfaelou

    2016-03-01

    Full Text Available This work is a short review of Photoactivated Fuel Cells, that is, photoelectrochemical cells which consume an organic or inorganic fuel to produce renewable electricity or hydrogen. The work presents the basic features of photoactivated fuel cells, their modes of operation, the materials, which are frequently used for their construction and some ideas of cell design both for electricity and solar hydrogen production. Water splitting is treated as a special case of photoactivated fuel cell operation.

  20. Renewable energy systems the earthscan expert guide to renewable energy technologies for home and business

    CERN Document Server

    Jenkins, Dilwyn

    2013-01-01

    This book is the long awaited guide for anyone interested in renewables at home or work. It sweeps away scores of common misconceptions while clearly illustrating the best in renewable and energy efficiency technologies. A fully illustrated guide to renewable energy for the home and small business, the book provides an expert overview of precisely which sustainable energy technologies are appropriate for wide-spread domestic and small business application. The sections on different renewable energy options provide detailed descriptions of each technology along with case studies, installatio

  1. Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal.

    Science.gov (United States)

    Chaix, Julie; Nish, Simone A; Lin, Wen-Hsuan W; Rothman, Nyanza J; Ding, Lei; Wherry, E John; Reiner, Steven L

    2014-08-01

    Central memory (CM) CD8(+) T cells "remember" prior encounters because they maintain themselves through cell division in the absence of ongoing challenge (homeostatic self-renewal), as well as reproduce the CM fate while manufacturing effector cells during secondary Ag encounters (rechallenge self-renewal). We tested the consequence of conditional deletion of the bone marrow homing receptor CXCR4 on antiviral T cell responses. CXCR4-deficient CD8(+) T cells have impaired memory cell maintenance due to defective homeostatic proliferation. Upon rechallenge, however, CXCR4-deficient T cells can re-expand and renew the CM pool while producing secondary effector cells. The critical bone marrow-derived signals essential for CD8(+) T cell homeostatic self-renewal appear to be dispensable to yield self-renewing, functionally asymmetric cell fates during rechallenge.

  2. Intermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line.

    Science.gov (United States)

    Cinquin, Amanda; Chiang, Michael; Paz, Adrian; Hallman, Sam; Yuan, Oliver; Vysniauskaite, Indre; Fowlkes, Charless C; Cinquin, Olivier

    2016-04-01

    Self-renewing organs often experience a decline in function in the course of aging. It is unclear whether chronological age or external factors control this decline, or whether it is driven by stem cell self-renewal-for example, because cycling cells exhaust their replicative capacity and become senescent. Here we assay the relationship between stem cell cycling and senescence in the Caenorhabditis elegans reproductive system, defining this senescence as the progressive decline in "reproductive capacity," i.e. in the number of progeny that can be produced until cessation of reproduction. We show that stem cell cycling diminishes remaining reproductive capacity, at least in part through the DNA damage response. Paradoxically, gonads kept under conditions that preclude reproduction keep cycling and producing cells that undergo apoptosis or are laid as unfertilized gametes, thus squandering reproductive capacity. We show that continued activity is in fact beneficial inasmuch as gonads that are active when reproduction is initiated have more sustained early progeny production. Intriguingly, continued cycling is intermittent-gonads switch between active and dormant states-and in all likelihood stochastic. Other organs face tradeoffs whereby stem cell cycling has the beneficial effect of providing freshly-differentiated cells and the detrimental effect of increasing the likelihood of cancer or senescence; stochastic stem cell cycling may allow for a subset of cells to preserve proliferative potential in old age, which may implement a strategy to deal with uncertainty as to the total amount of proliferation to be undergone over an organism's lifespan.

  3. Intermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line.

    Directory of Open Access Journals (Sweden)

    Amanda Cinquin

    2016-04-01

    Full Text Available Self-renewing organs often experience a decline in function in the course of aging. It is unclear whether chronological age or external factors control this decline, or whether it is driven by stem cell self-renewal-for example, because cycling cells exhaust their replicative capacity and become senescent. Here we assay the relationship between stem cell cycling and senescence in the Caenorhabditis elegans reproductive system, defining this senescence as the progressive decline in "reproductive capacity," i.e. in the number of progeny that can be produced until cessation of reproduction. We show that stem cell cycling diminishes remaining reproductive capacity, at least in part through the DNA damage response. Paradoxically, gonads kept under conditions that preclude reproduction keep cycling and producing cells that undergo apoptosis or are laid as unfertilized gametes, thus squandering reproductive capacity. We show that continued activity is in fact beneficial inasmuch as gonads that are active when reproduction is initiated have more sustained early progeny production. Intriguingly, continued cycling is intermittent-gonads switch between active and dormant states-and in all likelihood stochastic. Other organs face tradeoffs whereby stem cell cycling has the beneficial effect of providing freshly-differentiated cells and the detrimental effect of increasing the likelihood of cancer or senescence; stochastic stem cell cycling may allow for a subset of cells to preserve proliferative potential in old age, which may implement a strategy to deal with uncertainty as to the total amount of proliferation to be undergone over an organism's lifespan.

  4. Feasibility of synthetic fuels in renewable energy systems

    DEFF Research Database (Denmark)

    Ridjan, Iva; Mathiesen, Brian Vad; Connolly, David

    The transport sector is the only sector in which there have been no significant renewable energy penetrations and it is heavily dependent on oil with rapid growth in the last decades. Moreover, it is challenging to obviate the oil dependence due to the wide variety of modes and needs in the sector....... Nowadays, biofuels are proposed as one of the main options for replacing fossil fuels in the transport sector, along with electricity. The main reasons for avoiding the direct usage of biomass in the transport sector, i.e. producing biomass derived fuels, are land use shortage, limited biomass availability......, interference with food supplies, and other impacts on environment and biosphere. Hence, it is essential to do a detailed analysis of the transport sector in order to match the demand and to meet the criteria of a 100% renewable energy system in 2050....

  5. The feasibility of synthetic fuels in renewable energy systems

    DEFF Research Database (Denmark)

    Ridjan, Iva; Mathiesen, Brian Vad; Connolly, David

    2012-01-01

    The transport sector is the only sector in which there have been no significant renewable energy penetrations, it is heavily dependent on oil with rapid growth in the last decades. Moreover, it is challenging to obviate the oil dependence due to the wide variety of modes and needs in the sector....... Nowadays, biofuels along with electricity are proposed as one of the main options for replacing fossil fuels in the transport sector. The main reasons for avoiding the direct usage of biomass, i.e. producing biomass derived fuels, are land use shortage, limited biomass availability, interference with food...... supplies, and other impacts on environment and biosphere. Hence, it is essential to make a detailed analysis of this sector in order to match the demand and to meet the criteria of a 100% renewable energy system in 2050. The purpose of this article is to identify potential pathways for producing synthetic...

  6. Power Electronics and Control of Renewable Energy Systems

    DEFF Research Database (Denmark)

    Iov, Florin; Ciobotaru, Mihai; Sera, Dezso

    2007-01-01

    sources from the conventional, fossil (and short term) based energy sources to renewable energy resources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss some of the most emerging renewable energy sources......, wind energy and photovoltaics, which by means of power electronics are changing from being minor energy sources to be acting as important power sources in the energy system.......The global electrical energy consumption is still rising and there is a demand to double the power capacity within 20 years. The production, distribution and use of energy should be as technological efficient as possible and incentives to save energy at the end-user should also be set up...

  7. Power electronics - key technology for renewable energy systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Iov, Florin; Kerekes, Tamas

    2011-01-01

    sources to renewable energy sources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss trends of the most emerging renewable energy sources, wind energy and photovoltaics, which by means of power electronics...... are changing and challenging the future electrical infrastructure but also contributes steadily more to non-carbon based electricity production. Most focus in the paper is on the power electronics technologies used. In the case of photovoltaics transformer-less systems are discussed as they have the potential...... as efficient as possible. Further, the emerging climate changes is arguing to find sustainable future solutions. Of many options, two major technologies will play important roles to solve parts of those future problems. One is to change the electrical power production from conventional, fossil based energy...

  8. Trends in Power Electronics and Control of Renewable Energy Systems

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Iov, Florin; Kerekes, Tamas

    2010-01-01

    term) based energy sources to renewable energy sources. Another is to use high efficient power electronics in power generation, power transmission/distribution and end-user application. This paper discuss trends of the most emerging renewable energy sources, wind energy and photovoltaics, which...... by means of power electronics are changing the future electrical infrastructure but also contributes steadily more to non-carbon based electricity production. Most focus is on the power electronics technologies used. In the case of photovoltaics transformer-less systems are discussed as they have...... are done as efficient as possible. Further, emerging climate changes argues to find future solutions which also are sustainable. Two major technologies will play important roles to solve parts of those future problems. One is the change the electrical power production from conventional, fossil (and short...

  9. Easy Solar Photovoltaic Panel as Renewable Energy System Device

    Directory of Open Access Journals (Sweden)

    Kalaivani D/O Ramachandran

    2016-04-01

    Full Text Available Solar power is energy from the sun that is converted into electrical energy. Solar energy is the abundant renewable energy source available, and the Malaysia has some of the richest solar resources in the world. Electric energy is becoming one of the source energy which is required daily. However, electric power outages always happened. Easy Solar Photovoltaic Panel as Renewable Energy System Device isimplemented as an electric power source by using solar as a help and support. It is used by providing charge through solar panel from sunlight. Then, the charge is flowing through the solar controller to charges battery that will flow to the load. Since energy that obtained from the battery are shaped in direct current (DC, then the inverter used to change direct current (DC to alternating current (AC for purpose of using device or application that using alternating current (AC to operate.

  10. Study of renewable energy, fuel cell and demotics integration for stationary energy production

    Energy Technology Data Exchange (ETDEWEB)

    Andaloro, L.; Ferraro, M.; Sergi, F.; Brunaccini, G.; Antonucci, V. [National Research Inst., Messina (Italy)

    2009-07-01

    This paper described a study in which a small house equipped with various renewable technologies was modelled. The aim of the study was to evaluated the integration of fuel cells with various other energy sources. Technologies installed in the house included a photovoltaic (PV) system; a hydrogen system; fuel cells; a battery-storage system; and a thermal solar panel. Maximum energy savings were evaluated for different configurations and combinations of the installed energy sources. A domotic system was also used to automatically control the use of electrical appliances and improve safety and comfort. An energy side management system was designed and compared with a demand side management system. Various scenarios were simulated in order to test the energy management systems in relation to the automated domotic system.

  11. Renewable sustainable biocatalyzed electricity production in a photosynthetic algal microbial fuel cell (PAMFC).

    Science.gov (United States)

    Strik, David P B T B; Terlouw, Hilde; Hamelers, Hubertus V M; Buisman, Cees J N

    2008-12-01

    Electricity production via solar energy capturing by living higher plants and microalgae in combination with microbial fuel cells are attractive because these systems promise to generate useful energy in a renewable, sustainable, and efficient manner. This study describes the proof of principle of a photosynthetic algal microbial fuel cell (PAMFC) based on naturally selected algae and electrochemically active microorganisms in an open system and without addition of instable or toxic mediators. The developed solar-powered PAMFC produced continuously over 100 days renewable biocatalyzed electricity. The sustainable performance of the PAMFC resulted in a maximum current density of 539 mA/m2 projected anode surface area and a maximum power production of 110 mW/m2 surface area photobioreactor. The energy recovery of the PAMFC can be increased by optimization of the photobioreactor, by reducing the competition from non-electrochemically active microorganisms, by increasing the electrode surface and establishment of a further-enriched biofilm. Since the objective is to produce net renewable energy with algae, future research should also focus on the development of low energy input PAMFCs. This is because current algae production systems have energy inputs similar to the energy present in the outcoming valuable products.

  12. Bimode uninterruptible power supply compatibility in renewable hybrid energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Bower, W. (Sandia National Labs., Albuquerque, NM (USA)); O' Sullivan, G. (Abacus Controls, Inc., Somerville, NJ (USA))

    1990-08-01

    Inverters installed in renewable hybrid energy systems are typically used in a stand-alone mode to supply ac power to loads from battery storage when the engine-generator is not being used. Similarities in topology and in the performance requirements of the standby uninterruptible power supply (UPS) system and the hybrid system suggest the UPS could be used in hybrid energy systems. Another alternative to inverters with add-on charging circuits or standby UPS hardware is the Bimode UPS. The bimode UPS uses common circuitry and power components for dc to ac inversion and battery charging. It also provides an automatic and nearly instantaneous ac power transfer function when the engine-generator is started or stopped. The measured operating and transfer characteristics of a bimode UPS in a utility system and in a hybrid system are presented. The applicability of the bimode UPS to hybrid systems and its compatibility in a PV/engine-generator hybrid system are given.

  13. 77 FR 131 - Charter Renewal for the National Park System Advisory Board

    Science.gov (United States)

    2012-01-03

    ... National Park Service Charter Renewal for the National Park System Advisory Board AGENCY: Department of the... renew the charter for the National Park System Advisory Board, in accordance with section 14(b) of the... reauthorized legislatively within 2 years of the date of the renewal charter, the Board will revert to...

  14. A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages.

    Science.gov (United States)

    Pearson, Bret J; Sánchez Alvarado, Alejandro

    2010-01-01

    The functions of adult stem cells and tumor suppressor genes are known to intersect. However, when and how tumor suppressors function in the lineages produced by adult stem cells is unknown. With a large population of stem cells that can be manipulated and studied in vivo, the freshwater planarian is an ideal system with which to investigate these questions. Here, we focus on the tumor suppressor p53, homologs of which have no known role in stem cell biology in any invertebrate examined thus far. Planaria have a single p53 family member, Smed-p53, which is predominantly expressed in newly made stem cell progeny. When Smed-p53 is targeted by RNAi, the stem cell population increases at the expense of progeny, resulting in hyper-proliferation. However, ultimately the stem cell population fails to self-renew. Our results suggest that prior to the vertebrates, an ancestral p53-like molecule already had functions in stem cell proliferation control and self-renewal.

  15. Renewal of the waterpipe system at Norrköping

    OpenAIRE

    Kalm, Rickard

    2007-01-01

    The work with renewal of the water pipe system in Norrköpings municipality has during the last couple years been intensified due to disturbances in the pipe network. My task was to connect disturbances with their geographic position in a database and use the database to establish a priority list for measures. This paper will only examine the water pipe system and the disturbances that are depending on reports of leak in the pipes. The already existing database that was supposed to be the inpu...

  16. Fibroblast growth factors as regulators of stem cell self-renewal and aging

    NARCIS (Netherlands)

    Yeoh, Joyce S. G.; de Haan, Gerald

    2007-01-01

    Organ and tissue dysfunction which is readily observable during aging results from a loss of cellular homeostasis and reduced stem cell self-renewal. Over the past 10 years, studies have been aimed at delineating growth factors that will sustain and promote the self-renewal potential of stem cells a

  17. Final Progress Report, Renewable and Logistics Fuels for Fuel Cells at the Colorado School of Mines

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, Neal P. [Colorado School of Mines, Golden, CO (United States)

    2012-08-06

    The objective of this program is to advance the current state of technology of solid-oxide fuel cells (SOFCs) to improve performance when operating on renewable and logistics hydrocarbon fuel streams. Outcomes will include: 1.) new SOFC materials and architectures that address the technical challenges associated with carbon-deposit formation and sulfur poisoning; 2.) new integration strategies for combining fuel reformers with SOFCs; 3.) advanced modeling tools that bridge the scales of fundamental charge-transfer chemistry to system operation and control; and 4.) outreach through creation of the Distinguished Lecturer Series to promote nationwide collaboration with fuel-cell researchers and scientists.

  18. RETHINKING THE FUTURE GRID: INTEGRATED NUCLEAR-RENEWABLE ENERGY SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    S.M. Bragg-Sitton; R. Boardman

    2014-12-01

    The 2013 electricity generation mix in the United States consisted of ~13% renewables (hydropower, wind, solar, geothermal), 19% nuclear, 27% natural gas, and 39% coal. In the 2011 State of the Union Address, President Obama set a clean energy goal for the nation: “By 2035, 80 percent of America’s electricity will come from clean energy sources. Some folks want wind and solar. Others want nuclear, clean coal and natural gas. To meet this goal we will need them all.” The U.S. Department of Energy (DOE) Offices of Nuclear Energy (NE) and Energy Efficiency and Renewable Energy (EERE) recognize that “all of the above” means that we are called to best utilize all available clean energy sources. To meet the stated environmental goals for electricity generation and for the broader energy sector, there is a need to transform the energy infrastructure of the U.S. and elsewhere. New energy systems must be capable of significantly reducing environmental impacts in an efficient and economically viable manner while utilizing both hydrocarbon resources and clean energy generation sources. The U.S. DOE is supporting research and development that could lead to more efficient utilization of clean energy generation sources, including renewable and nuclear options, to meet both grid demand and thermal energy needs in the industrial sector. A concept being advanced by the DOE-NE and DOE-EERE is tighter coupling of nuclear and renewable energy sources in a manner that better optimizes energy use for the combined electricity, industrial manufacturing, and the transportation sectors. This integration concept has been referred to as a “hybrid system” that is capable of apportioning thermal and electrical energy to first meet the grid demand (with appropriate power conversion systems), then utilizing excess thermal and, in some cases, electrical energy to drive a process that results in an additional product. For the purposes of the present work, the hybrid system would

  19. Control analysis of renewable energy system with hydrogen storage for residential applications

    Science.gov (United States)

    Bilodeau, A.; Agbossou, K.

    The combination of an electrolyzer and a fuel cell can provide peak power control in a decentralized/distributed power system. The electrolyzer produces hydrogen and oxygen from off-peak electricity generated by the renewable energy sources (wind turbine and photovoltaic array), for later use in the fuel cell to produce on-peak electricity. An issue related to this system is the control of the hydrogen loop (electrolyzer, tank, fuel cell). A number of control algorithms were developed to decide when to produce hydrogen and when to convert it back to electricity, most of them assuming that the electrolyzer and the fuel cell run alternatively to provide nominal power (full power). This paper presents a complete model of a stand-alone renewable energy system with hydrogen storage controlled by a dynamic fuzzy logic controller (FLC). In this system, batteries are used as energy buffers and for short time storage. To study the behavior of such a system, a complete model is developed by integrating the individual sub-models of the fuel cell, the electrolyzer, the power conditioning units, the hydrogen storage system, and the batteries. An analysis of the performances of the dynamic fuzzy logic controller is then presented. This model is useful for building efficient peak power control.

  20. Stem cell signaling. An integral program for tissue renewal and regeneration : Wnt signaling and stem cell control

    NARCIS (Netherlands)

    Clevers, Hans; Loh, Kyle M; Nusse, Roel

    2014-01-01

    Stem cells fuel tissue development, renewal, and regeneration, and these activities are controlled by the local stem cell microenvironment, the "niche." Wnt signals emanating from the niche can act as self-renewal factors for stem cells in multiple mammalian tissues. Wnt proteins are lipid-modified,

  1. Use of hybrid renewable energy systems for small communities

    Directory of Open Access Journals (Sweden)

    Bandoc Georgeta

    2016-01-01

    Full Text Available The purpose of this article is to present how the sizing of a hybrid renewable energy system is done for a community of three hundred and five households located in a Delta, starting from the optimization of hybrid energy system for a single household. The methodology used in solving this problem is based on multiple options. The first option consists in determined energy needs, maximum power consumption in cold season and in adapting the solution for the production of electricity by a hybrid plant. The second option consists of energy needs resulted in average consumption of electricity in warm season and in adapting the solution for the production of electricity from a hybrid plant. In conjunction with the demand for electricity for the entire community one will get energy demand by aggregating household level (kWh/household. The novelty of this approach lies in the method used by these hybrid systems for obtaining electricity in small communities, isolated from this case study. Based on the results obtained the method can be expanded the implementation of these projects that use hybrid renewable energy systems.

  2. Stem cell self-renewal in intestinal crypt

    Energy Technology Data Exchange (ETDEWEB)

    Simons, Benjamin D., E-mail: bds10@cam.ac.uk [Cavendish Laboratory, Department of Physics, J.J. Thomson Avenue, University of Cambridge, Cambridge CB3 0HE (United Kingdom); The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN (United Kingdom); Clevers, Hans, E-mail: h.clevers@hubrecht.eu [Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht (Netherlands)

    2011-11-15

    As a rapidly cycling tissue capable of fast repair and regeneration, the intestinal epithelium has emerged as a favored model system to explore the principles of adult stem cell biology. However, until recently, the identity and characteristics of the stem cell population in both the small intestine and colon has remained the subject of debate. Recent studies based on targeted lineage tracing strategies, combined with the development of an organotypic culture system, have identified the crypt base columnar cell as the intestinal stem cell, and have unveiled the strategy by which the balance between proliferation and differentiation is maintained. These results show that intestinal stem cells operate in a dynamic environment in which frequent and stochastic stem cell loss is compensated by the proliferation of neighboring stem cells. We review the basis of these experimental findings and the insights they offer into the mechanisms of homeostatic stem cell regulation.

  3. Transition to 100% renewable energy systems in Denmark

    DEFF Research Database (Denmark)

    Meyer, Niels I; Hvelplund, Frede; Karnø, Peter;

    2012-01-01

    The world is faced with urgent and complex climate problems manifested by increasing global warming due to emission of greenhouse gases. A major part of the greenhouse gases arise in the form of CO2 from combustion of fossil fuels. So far, however, international negotiations aiming at commitments...... the commercial market can offer. As a consequence, it is proposed that the balance between the commercial market and societal planning is shifted to the advantage of societal planning. It is an extra benefit from the proposed transition to a renewable energy system that it significantly improves the Danish...

  4. High Efficiency Bi-Directional Converter Used For Renewable System

    Directory of Open Access Journals (Sweden)

    M. Desal Raja

    2014-02-01

    Full Text Available This paper presents an Isolated bi-directional converter for renewable system. Voltage stress and current stress was decreses in switches. Power flows in both side. The proposed converter three phase ac voltage to dc voltage, dc voltage to three phase a.c voltage and synchronous the two voltage source. Silicon carbide diodes and bi-directional switches Mosfet’s are used for decreases the switching loss. LC Series resonant converter connected to the high efficiency. This converter power conversion control by the output voltage information.

  5. Limitations on hydrogen production in a renewable regenerative energy system due to thermal transients

    Energy Technology Data Exchange (ETDEWEB)

    Bergen, A.; Djilali, N.; Pitt, L.; Rowe, A.; Wild, P. [Victoria Univ., BC (Canada). Inst. for Integrated Energy Systems

    2007-07-01

    The integrated renewable energy experiment (IRENE) was developed to aid in the development of simulation tools for renewable energy-based distributed residential-scale hydrogen systems. This study focused on evaluating the interactions between system components that influence hydrogen production. The principal components of IRENE included a controllable input power source, power conversion elements; AC load devices; a hydrogen storage system; a fuel cell loop; and, a control and data acquisition system. The system was fully instrumented to measure mass and energy flows between system elements. A simplified power conditioning unit was used to allow throttling of the current to the electrolyser by passively reducing the input voltage. Power transfer to the electrolyser was limited at low bus voltages. A power input profile was used to validate the modelling electrolyser step function response predictions with IRENE's experimental data. Preliminary experimental results showed that some modelling assumptions made for renewable hydrogen systems over-estimate hydrogen production capabilities. Values obtained were between 10 to 20 per cent lower than values typically reported in the literature. It was concluded that the thermal characteristics and bus limiting interactions should be considered if accurate modelling of hydrogen production capacity is required. 11 refs., 1 tab., 4 figs.

  6. Renewable Energy Systems in the Power Electronics Curriculum

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Chen, Zhe; Teodorescu, Remus

    2005-01-01

    Power Electronics is still an emerging technology and its applications are increasing. The primary function is to convert electrical energy from one stage to another and it is used in many different applications. The power electronics curriculum is multidisciplinary covering fields like devices......, magnetics, electrical machines, power systems, analogue and digital control, materials, power converters, electronics, materials, thermal design and EMC. However, those fields may not be enough in order to give the students enough skills. It is also necessary to learn about systems and for the moment one...... of the most important area is renewable energy systems. This paper will discuss the basic courses for the power electronics curriculum. It will also discuss how to teach power electronic systems efficiently through a projectoriented and problem-based learning approach with Aalborg University in Denmark...

  7. Energy Storage Applications in Power Systems with Renewable Energy Generation

    Science.gov (United States)

    Ghofrani, Mahmoud

    In this dissertation, we propose new operational and planning methodologies for power systems with renewable energy sources. A probabilistic optimal power flow (POPF) is developed to model wind power variations and evaluate the power system operation with intermittent renewable energy generation. The methodology is used to calculate the operating and ramping reserves that are required to compensate for power system uncertainties. Distributed wind generation is introduced as an operational scheme to take advantage of the spatial diversity of renewable energy resources and reduce wind power fluctuations using low or uncorrelated wind farms. The POPF is demonstrated using the IEEE 24-bus system where the proposed operational scheme reduces the operating and ramping reserve requirements and operation and congestion cost of the system as compared to operational practices available in the literature. A stochastic operational-planning framework is also proposed to adequately size, optimally place and schedule storage units within power systems with high wind penetrations. The method is used for different applications of energy storage systems for renewable energy integration. These applications include market-based opportunities such as renewable energy time-shift, renewable capacity firming, and transmission and distribution upgrade deferral in the form of revenue or reduced cost and storage-related societal benefits such as integration of more renewables, reduced emissions and improved utilization of grid assets. A power-pool model which incorporates the one-sided auction market into POPF is developed. The model considers storage units as market participants submitting hourly price bids in the form of marginal costs. This provides an accurate market-clearing process as compared to the 'price-taker' analysis available in the literature where the effects of large-scale storage units on the market-clearing prices are neglected. Different case studies are provided to

  8. Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling.

    Science.gov (United States)

    Chen, Su-Ren; Liu, Yi-Xun

    2015-04-01

    Spermatogenesis is a continuous and productive process supported by the self-renewal and differentiation of spermatogonial stem cells (SSCs), which arise from undifferentiated precursors known as gonocytes and are strictly controlled in a special 'niche' microenvironment in the seminiferous tubules. Sertoli cells, the only somatic cell type in the tubules, directly interact with SSCs to control their proliferation and differentiation through the secretion of specific factors. Spermatocyte meiosis is another key step of spermatogenesis, which is regulated by Sertoli cells on the luminal side of the blood-testis barrier through paracrine signaling. In this review, we mainly focus on the role of Sertoli cells in the regulation of SSC self-renewal and spermatocyte meiosis, with particular emphasis on paracrine and endocrine-mediated signaling pathways. Sertoli cell growth factors, such as glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2), as well as Sertoli cell transcription factors, such as ETS variant 5 (ERM; also known as ETV5), nociceptin, neuregulin 1 (NRG1), and androgen receptor (AR), have been identified as the most important upstream factors that regulate SSC self-renewal and spermatocyte meiosis. Other transcription factors and signaling pathways (GDNF-RET-GFRA1 signaling, FGF2-MAP2K1 signaling, CXCL12-CXCR4 signaling, CCL9-CCR1 signaling, FSH-nociceptin/OPRL1, retinoic acid/FSH-NRG/ERBB4, and AR/RB-ARID4A/ARID4B) are also addressed.

  9. Modeling of an Integrated Renewable Energy System (IRES) with hydrogen storage

    Science.gov (United States)

    Shenoy, Navin Kodange

    2010-12-01

    Scope and Method of Study. The purpose of the study was to consider the integration of hydrogen storage technology as means of energy storage with renewable sources of energy. Hydrogen storage technology consists of an alkaline electrolyzer, gas storage tank and a fuel cell. The Integrated Renewable Energy System (IRES) under consideration includes wind energy, solar energy from photovoltaics, solar thermal energy and biomass energy in the form of biogas. Energy needs are categorized depending on the type and quality of the energy requirements. After meeting all the energy needs, any excess energy available from wind and PVs is converted into hydrogen using an electrolyzer for later use in a fuel cell. Similarly, when renewable energy generation is not able to supply the actual load demand, the stored hydrogen is utilized through fuel cell to fulfill load demand. Analysis of how IRES operates in order to satisfy different types of energy needs is discussed. Findings and Conclusions. All simulations are performed using MATLAB software. Hydrogen storage technology consisting of an electrolyzer, gas storage tank and a fuel cell is incorporated in the IRES design process for a hypothetical remote community. Results show that whenever renewable energy generated is greater than the electrical demand, excess energy is stored in the form of hydrogen and in case of energy shortfall, the stored hydrogen is utilized through the fuel cell to supply to excess power demand. The overall operation of IRES is enhanced as a result of energy storage in the form of hydrogen. Hydrogen has immense potential to be the energy carrier of the future because of its clean character and the model of hydrogen storage discussed here can form an integral part of IRES for remote area applications.

  10. Power System Study for Renewable Energy Interconnection in Malaysia

    Science.gov (United States)

    Askar, O. F.; Ramachandaramurthy, V. K.

    2013-06-01

    The renewable energy (RE) sector has grown exponentially in Malaysia with the introduction of the Feed-In-Tariff (FIT) by the Ministry of Energy, Green Technology and Water. Photovoltaic, biogas, biomass and mini hydro are among the renewable energy sources which offer a lucrative tariff to incite developers in taking the green technology route. In order to receive the FIT, a developer is required by the utility company to perform a power system analysis which will determine the technical feasibility of an RE interconnection to the utility company's existing grid system. There are a number of aspects which the analysis looks at, the most important being the load flow and fault levels in the network after the introduction of an RE source. The analysis is done by modelling the utility company's existing network and simulating the network with the interconnection of an RE source. The results are then compared to the values before an interconnection is made as well as ensuring the voltage rise or the increase in fault levels do not violate any pre-existing regulations set by the utility company. This paper will delve into the mechanics of performing a load flow analysis and examining the results obtained.

  11. Optimizing the U.S. Electric System with a High Penetration of Renewables

    Science.gov (United States)

    Corcoran, B. A.; Jacobson, M. Z.

    2013-12-01

    As renewable energy generators are increasingly being installed throughout the U.S., there is growing interest in interconnecting diverse renewable generators (primarily wind and solar) across large geographic areas through an enhanced transmission system. This reduces variability in the aggregate power output, increases system reliability, and allows for the development of the best overall group of renewable technologies and sites to meet the load. Studies are therefore needed to determine the most efficient and economical plan to achieve large area interconnections in a future electric system with a high penetration of renewables. This research quantifies the effects of aggregating electric load together with diverse renewable generation throughout the ten Federal Energy Regulatory Commission (FERC) regions in the contiguous U.S. A deterministic linear program has been built in AMPL (A Mathematical Programming Language) to solve for the least-cost organizational structure and system (generators, transmission, and storage) for a highly renewable electric grid. The analysis will 1) examine a highly renewable 2006 electric system, including various sensitivity cases and additional system components such as additional load from electric vehicles, and 2) create a 'roadmap' from the existing 2006 system to a highly renewable system in 2030, accounting for projected price and demand changes and generator retirements based on age and environmental regulations. Ideally, results from this study will offer insight for a federal renewable energy policy (such as a renewable portfolio standard) and how to best organize U.S. regions for transmission planning.

  12. Tissue-resident adult stem cell populations of rapidly self-renewing organs

    NARCIS (Netherlands)

    Barker, N.; Bartfeld, S.; Clevers, H.

    2010-01-01

    The epithelial lining of the intestine, stomach, and skin is continuously exposed to environmental assault, imposing a requirement for regular self-renewal. Resident adult stem cell populations drive this renewal, and much effort has been invested in revealing their identity. Reliable adult stem cel

  13. Stem cell self-renewal in intestinal crypt

    NARCIS (Netherlands)

    Simons, B.D.; Clevers, H.

    2011-01-01

    As a rapidly cycling tissue capable of fast repair and regeneration, the intestinal epithelium has emerged as a favored model system to explore the principles of adult stem cell biology. However, until recently, the identity and characteristics of the stem cell population in both the small intestine

  14. Power quality analysis of hybrid renewable energy system

    Directory of Open Access Journals (Sweden)

    Rinchin W. Mosobi

    2015-12-01

    Full Text Available An hybrid renewable energy sources consisting of solar photovoltaic, wind energy system, and a microhydro system is proposed in this paper. This system is suitable for supplying electricity to isolated locations or remote villages far from the grid supply. The solar photovoltaic system is modeled with two power converters, the first one being a DC-DC converter along with an maximum power point tracking to achieve a regulated DC output voltage and the second one being a DC-AC converter to obtain AC output. The wind energy system is modeled with a wind-turbine prime mover with varying wind speed and fixed pitch angle to drive an self excited induction generator (SEIG. Owing to inherent drooping characteristics of the SEIG, a closed loop turbine input system is incorporated. The microhydro system is modeled with a constant input power to drive an SEIG. The three different sources are integrated through an AC bus and the proposed hybrid system is supplied to R, R-L, and induction motor loads. A static compensator is proposed to improve the load voltage and current profiles; it also mitigates the harmonic contents of the voltage and current. The static synchronous compensator is realized by means of a three-phase IGBT-based current-controlled voltage source inverter with a self-supporting DC bus. The complete system is modeled and simulated using Matlab/Simulink. The simulation results obtained illustrate the feasibility of the proposed system and are found to be satisfactory.

  15. Temporal Changes in FLT3-ITD Regulation of Stem Cell Self-Renewal and Leukemogenesis

    Science.gov (United States)

    2015-09-01

    effects on hematopoietic stem cells (HSCs) and other hematopoietic progenitors, we have been characterizing its function in fetal , neonatal and adult...1 AWARD NUMBER: W81XWH-14-1-0120 TITLE: Temporal Changes in FLT3-ITD Regulation of Stem Cell Self-Renewal and Leukemogenesis PRINCIPAL...2015 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Temporal Changes in FLT3-ITD Regulation of Stem Cell Self-Renewal and Leukemogenesis 5b. GRANT

  16. Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ruoxing [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States); Guo, Yan-Lin, E-mail: yanlin.guo@usm.edu [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States)

    2012-10-01

    Embryonic stem cells (ESCs) have unlimited capacity for self-renewal and can differentiate into various cell types when induced. They also have an unusual cell cycle control mechanism driven by constitutively active cyclin dependent kinases (Cdks). In mouse ESCs (mESCs). It is proposed that the rapid cell proliferation could be a necessary part of mechanisms that maintain mESC self-renewal and pluripotency, but this hypothesis is not in line with the finding in human ESCs (hESCs) that the length of the cell cycle is similar to differentiated cells. Therefore, whether rapid cell proliferation is essential for the maintenance of mESC state remains unclear. We provide insight into this uncertainty through chemical intervention of mESC cell cycle. We report here that inhibition of Cdks with olomoucine II can dramatically slow down cell proliferation of mESCs with concurrent down-regulation of cyclin A, B and E, and the activation of the Rb pathway. However, mESCs display can recover upon the removal of olomoucine II and are able to resume normal cell proliferation without losing self-renewal and pluripotency, as demonstrated by the expression of ESC markers, colony formation, embryoid body formation, and induced differentiation. We provide a mechanistic explanation for these observations by demonstrating that Oct4 and Nanog, two major transcription factors that play critical roles in the maintenance of ESC properties, are up-regulated via de novo protein synthesis when the cells are exposed to olomoucine II. Together, our data suggest that short-term inhibition of cell proliferation does not compromise the basic properties of mESCs. -- Highlights: Black-Right-Pointing-Pointer Inhibition of Cdks slows down mESCs proliferation. Black-Right-Pointing-Pointer mESCs display remarkable recovery capacity from short-term cell cycle interruption. Black-Right-Pointing-Pointer Short-term cell cycle interruption does not compromise mESC self-renewal. Black

  17. Renewable Energy, Photovoltaic Systems Near Airfields. Electromagnetic Interference

    Energy Technology Data Exchange (ETDEWEB)

    Deline, Chris [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Dann, Geoff [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2015-04-01

    Recent increases in photovoltaic (PV) systems on Department of the Navy (DON) land and potential siting near airfields prompted Commander, Naval Installations Command to fund the Naval Facilities Engineering Command to evaluate the impact of electromagnetic interference (EMI) from PV systems on airfield electronic equipment. Naval Facilities Engineering and Expeditionary Warfare Center tasked Department of Energy National Renewable Energy laboratory (NREL) to conduct the assessment. PV systems often include high-speed switching semiconductor circuits to convert the voltage produced by the PV arrays to the voltage needed by the end user. Switching circuits inherently produce electromagnetic radiation at harmonics of the switching frequency. In this report, existing literature is summarized and tests to measure emissions and mitigation methods are discussed. The literature shows that the emissions from typical PV systems are low strength and unlikely to cause interference to most airfield electronic systems. With diligent procurement and siting of PV systems, including specifications for FCC Part 15 Class A compliant equipment and a 250-foot setback from communication equipment, NREL anticipates little to no EMI impact on nearby communications or telemetry equipment.

  18. Comparison study between a Renewable Energy Supply System and a supergrid for achieving 100% from renewable energy sources in Islands

    DEFF Research Database (Denmark)

    Xydis, George

    2013-01-01

    Numerous efforts have been done for achieving the maximum penetration of renewable energy sources (RESs) in the autonomous grids of Greek islands, which never exceeded 10%, despite the exceptional wind and solar potential. Large fluctuations on demand during summer, winter, and 24-h period...... in combination with the technical restrictions of diesel generators of the existing conventional power stations are a major concern of power supply system. Reversing the roles of diesel generators and wind farms (WFs), to use WF as the basic energy source and diesel generators as stand-by system changed in fact...... the stochastic behavior of wind energy to the demand, to provide the system with guaranteed power. This Wind–Hydro Plants in combination with the most adequate RES forming an Renewable Energy Supply System (RESS), increase further the economical penetration of RES into autonomous grids up to 90% or even 100...

  19. Renewal processes

    CERN Document Server

    Mitov, Kosto V

    2014-01-01

    This monograph serves as an introductory text to classical renewal theory and some of its applications for graduate students and researchers in mathematics and probability theory. Renewal processes play an important part in modeling many phenomena in insurance, finance, queuing systems, inventory control and other areas. In this book, an overview of univariate renewal theory is given and renewal processes in the non-lattice and lattice case are discussed. A pre-requisite is a basic knowledge of probability theory.

  20. Is Every Irreducible Shift of Finite Type Flow Equivalent to a Renewal System?

    DEFF Research Database (Denmark)

    Johansen, Rune

    2013-01-01

    systems of finite type. In particular, it is shown that the Bowen–Franks group is cyclic for every member of a class of renewal systems known to attain all entropies realised by shifts of finite type, and several classes of renewal systems with non-trivial values of the invariant are constructed....

  1. Modeling sustainability in renewable energy supply chain systems

    Science.gov (United States)

    Xie, Fei

    This dissertation aims at modeling sustainability of renewable fuel supply chain systems against emerging challenges. In particular, the dissertation focuses on the biofuel supply chain system design, and manages to develop advanced modeling framework and corresponding solution methods in tackling challenges in sustaining biofuel supply chain systems. These challenges include: (1) to integrate "environmental thinking" into the long-term biofuel supply chain planning; (2) to adopt multimodal transportation to mitigate seasonality in biofuel supply chain operations; (3) to provide strategies in hedging against uncertainty from conversion technology; and (4) to develop methodologies in long-term sequential planning of the biofuel supply chain under uncertainties. All models are mixed integer programs, which also involves multi-objective programming method and two-stage/multistage stochastic programming methods. In particular for the long-term sequential planning under uncertainties, to reduce the computational challenges due to the exponential expansion of the scenario tree, I also developed efficient ND-Max method which is more efficient than CPLEX and Nested Decomposition method. Through result analysis of four independent studies, it is found that the proposed modeling frameworks can effectively improve the economic performance, enhance environmental benefits and reduce risks due to systems uncertainties for the biofuel supply chain systems.

  2. The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal

    DEFF Research Database (Denmark)

    Stewart, Morag H; Albert, Mareike; Sroczynska, Patrycja;

    2015-01-01

    Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and differentiation in stem cells and cancer, however its function in hematopoiesis is unclear. Here, we find that Jarid1b is highly expressed in primitive hematopoietic compartments and is overexpressed in acute myeloid leukemias...... compromises hematopoietic stem cell (HSC) self-renewal capacity and suggest that Jarid1b is a positive regulator of HSC potential....

  3. Alveolar progenitor and stem cells in lung development, renewal and cancer.

    Science.gov (United States)

    Desai, Tushar J; Brownfield, Douglas G; Krasnow, Mark A

    2014-03-13

    Alveoli are gas-exchange sacs lined by squamous alveolar type (AT) 1 cells and cuboidal, surfactant-secreting AT2 cells. Classical studies suggested that AT1 arise from AT2 cells, but recent studies propose other sources. Here we use molecular markers, lineage tracing and clonal analysis to map alveolar progenitors throughout the mouse lifespan. We show that, during development, AT1 and AT2 cells arise directly from a bipotent progenitor, whereas after birth new AT1 cells derive from rare, self-renewing, long-lived, mature AT2 cells that produce slowly expanding clonal foci of alveolar renewal. This stem-cell function is broadly activated by AT1 injury, and AT2 self-renewal is selectively induced by EGFR (epidermal growth factor receptor) ligands in vitro and oncogenic Kras(G12D) in vivo, efficiently generating multifocal, clonal adenomas. Thus, there is a switch after birth, when AT2 cells function as stem cells that contribute to alveolar renewal, repair and cancer. We propose that local signals regulate AT2 stem-cell activity: a signal transduced by EGFR-KRAS controls self-renewal and is hijacked during oncogenesis, whereas another signal controls reprogramming to AT1 fate.

  4. Advanced superconducting power conditioning system with SMES for effective use of renewable energy

    Science.gov (United States)

    Hamajima, T.; Tsuda, M.; Miyagi, D.; Amata, H.; Iwasaki, T.; Son, K.; Atomura, N.; Shintomi, T.; Makida, Y.; Takao, T.; Munakata, K.; Kajiwara, M.

    Since it is an urgent issue to reduce the global Carbon-dioxide in the world, renewable energy should be supplied as a large amount of the electric power. However, if a large amount of fluctuating renewable energy becomes more than adjustable amount of a utility grid capacity, instabilities such as frequency deviation might occur. We propose a system that is composed of SMES and FC-H2-Electrolyzer and also installed adjacent to Liquid Hydrogen station to cool down the SMES. Since the SMES has potentials of quick response and large I/O power, and Fuel Cell has potentials of slow response and steady power supplied from a large amount of hydrogen, we combine both storage devices and apply them to suppress the fluctuating power. We convert the fluctuating power to the constant power by using a developed prediction technology of Kalman filter to predict a trend of the fluctuating power. While the trend power should be supplied by FC or absorbed by the electrolyzer to produce hydrogen, the power difference between the renewable power and the trend power should be stored by the SMES. We simulate the power balance and analyze the required SMES capacity, design the concept of the SMES, and propose an operation algorithm for the SMES to estimate the electric efficiency of the system. It is found that the electric efficiency of the ASPCS can become greater than that of a pumped hydro-machine.

  5. Renewable energy in energy efficient, low-pollution systems

    Energy Technology Data Exchange (ETDEWEB)

    Johansson, Bengt

    1997-03-01

    Energy use accounts for the dominating fraction of total sulphur dioxide (SO{sub 2}), nitrogen oxide (NO{sub x}), volatile organic compounds (VOCs) and carbon dioxide (CO{sub 2}) emissions. In this thesis, different strategies for reducing these emissions are evaluated, using a bottom-up approach. CO{sub 2} emissions from electricity and heat production in western Scania, Sweden, can be reduced by 25% and the emissions of acidifying gases (SO{sub 2} and NO{sub x}) by 50% by the year 2010, compared with 1988 levels, using energy systems based on efficient end-use technologies, cogeneration of heat and electricity, renewable energy sources and low-pollution energy conversion technologies. Exhaust-pipe NO{sub x} emissions from the Swedish transportation sector can be reduced by 50 percent by the year 2015, compared with 1991, by implementing the best available vehicle technologies. Exhaust-pipe emissions of CO{sub 2} can be stabilized at the 1991 level. With further technical development and the use of fuels from renewable sources of energy, NO{sub x} emissions can be reduced by 75 percent and CO{sub 2} emissions by 80 percent compared with 1991 levels. Swedish biomass resources are large, and, assuming production conditions around 2015, about 200 TWh/year could be utilised for energy. Major reductions in CO{sub 2} emissions could be achieved by substituting biomass for fossil fuels in heat, electricity and transportation fuel production. Transportation fuels produced from cellulosic biomass are likely to be less expensive than transportation fuels from conventional biomass feedstocks such as oil plants, sugar-beet and cereals. 90 refs, 3 figs, 5 tabs

  6. Heating technologies for limiting biomass consumption in 100% renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Connolly, David

    2011-01-01

    district heating enables the use of combined heat and power production (CPH) and other renewable resources than biomass such as large-scale solar thermal, large-heat pumps, geothermal heat, industrial surplus heat etc. which is important for reducing the biomass consumption. Where the energy density......The utilisation of biomass poses large challenges in renewable energy systems and buildings account for a substantial part of the energy supply also in 100% renewable energy systems. The analyses of heating technologies show that district heating systems are especially important in limiting...... the dependence on biomass resources and to create cost effective systems. District heating systems are especially important in renewable energy systems with large amounts of fluctuating renewable energy sources as it enables fuel efficient and lower cost energy systems with thermal heat storages. And also...

  7. Self-Renewal and Pluripotency Acquired through Somatic Reprogramming to Human Cancer Stem Cells.

    OpenAIRE

    2012-01-01

    Human induced pluripotent stem cells (iPSCs) are reprogrammed by transient expression of transcription factors in somatic cells. Approximately 1% of somatic cells can be reprogrammed into iPSCs, while the remaining somatic cells are differentially reprogrammed. Here, we established induced pluripotent cancer stem-like cells (iCSCs) as self-renewing pluripotent cell clones. Stable iCSC lines were established from unstable induced epithelial stem cell (iESC) lines through re-plating followed by...

  8. CD8+ T Lymphocyte Self-Renewal during Effector Cell Determination

    Directory of Open Access Journals (Sweden)

    Wen-Hsuan W. Lin

    2016-11-01

    Full Text Available Selected CD8+ T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the transcription factor TCF1 marks loss of self-renewal by determined effector cells and that this requires cell division. In acute infections, the first three CD8+ T cell divisions produce daughter cells with unequal proliferative signaling but uniform maintenance of TCF1 expression. The more quiescent initial daughter cells resemble canonical central memory cells. The more proliferative, effector-prone cells from initial divisions can subsequently undergo division-dependent production of a TCF1-negative effector daughter cell along with a self-renewing TCF1-positive daughter cell, the latter also contributing to the memory cell pool upon resolution of infection. Self-renewal in the face of effector cell determination may promote clonal amplification and memory cell formation in acute infections, sustain effector regeneration during persistent subclinical infections, and be rate limiting, but remediable, in chronic active infections and cancer.

  9. Analysis of a hybrid renewable energy system on the Mures valley using Homer

    Directory of Open Access Journals (Sweden)

    Dumitru Cristian Dragoş

    2011-12-01

    Full Text Available Renewable energy technologies offer the promise of clean, abundant energy gathered from self-renewing resources such as the sun, wind, earth, and plants. Virtually all regions of the world have renewable resources of one type or another. This paper deals with the modeling and analysis of a hybrid system based on renewable energy resources, located on the Mureş valley, using a dedicated software named HOMER. Different types and topologies of renewable resources for the energy supply are analyzed; a small consumer situated on the Mureş Valley is modeled based on a load curve. Finally, the energy flows between the renewable energy system and the local supplying network are analyzed.

  10. A Review of Hybrid Renewable Energy Systems for Electric Power Generation

    Directory of Open Access Journals (Sweden)

    Md. Ibrahim

    2015-08-01

    Full Text Available Integration and combined utilization of renewable energy sources are becoming increasingly attractive. This paper is a review of hybrid renewable energy systems technologies for power generation, important issues and challenges in their design stage. Generation technology selection and unit sizing, System configurations and Energy management and control are discussed. Applications of hybrid energy systems, advantages of hybrid energy systems, issues and problems related to hybrid energy systems and an overview of energy storage technologies for renewable energy systems are presented. This paper also highlights the future trends of Hybrid energy systems, which represent a promising sustainable solution for power generation.

  11. Scales of renewability exemplified by a case study of three Danish pig production systems

    DEFF Research Database (Denmark)

    Wright, Christina; Østergård, Hanne

    2015-01-01

    (C)) exemplifies the use of this set of indicators. The results show that at the on-site scale the pig production systems had about the same fraction of renewable inputs of less than 0.5%. However, when the renewability fraction of inputs was accounted for at the global scale, the two organic systems...

  12. The design of Smart Energy Systems for 100% renewable energy and transport solutions

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Connolly, David

    2013-01-01

    In this paper we launch the design of Smart Energy Systems through the 100% renewable energy system analyses and research behind the CEESA research project. The transition from fossil fuels towards the integration of more and more renewable energy requires rethinking and redesign of the energy...

  13. The Evolution of Power System Planning with High Levels of Variable Renewable Generation

    Energy Technology Data Exchange (ETDEWEB)

    Katz, Jessica [National Renewable Energy Lab. (NREL), Golden, CO (United States); Milligan, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-09-01

    Greening the Grid provides technical assistance to energy system planners, regulators, and grid operators to overcome challenges associated with integrating variable renewable energy into the grid. This document, part of the Greening the Grid introduces the evolution of power system planning with high levels of variable renewable generation.

  14. 78 FR 79005 - Charter Renewal for the National Park System Advisory Board

    Science.gov (United States)

    2013-12-27

    ... National Park Service Charter Renewal for the National Park System Advisory Board AGENCY: National Park... charter for the National Park System Advisory Board, in accordance with section 14(b) of the Federal... reauthorized legislatively within 2 years of the date of the renewal charter, the Board will revert to...

  15. Argonaute-2-null embryonic stem cells are retarded in self-renewal and differentiation

    Indian Academy of Sciences (India)

    P Chandra Shekar; Adnan Naim; D Partha Sarathi; Satish Kumar

    2011-09-01

    RNA interference (RNAi) pathways regulate self-renewal and differentiation of embryonic stem (ES) cells. Argonaute 2 (Ago2) is a vital component of RNA-induced silencing complex (RISC) and the only Ago protein with slicer activity. We generated Ago2-deficient ES cells by conditional gene targeting. Ago2-deficient ES cells are defective in the small-RNA-mediated gene silencing and are significantly compromised in biogenesis of mature microRNA. The self-renewal rate of Ago2-deficient ES cells is affected due to failure of silencing of Cdkn1a by ES-cell-specific microRNAs (miRNA) in the absence of Ago2. Interestingly, unlike Dicer- and Dgcr8-deficient ES cells, they differentiate to all three germ layers both in vivo and in vitro. However, early differentiation of Ago2-deficient ES cells is delayed by 2–4 days as indicated by persistence of higher levels of self-renewal/ pluripotency markers during differentiation. Further, appearance of morphological and differentiation markers is also delayed during the differentiation. In this study we show that Ago2 is essential for normal self-renewal and differentiation. Also, our data suggest that self-renewal and differentiation of ES cells are regulated by both siRNA and miRNA pathways.

  16. Impacts of Renewable Energy Quota System on China's Future Power Sector

    OpenAIRE

    Xiong, Weiming; Zhang, Da; Mischke, Peggy; Zhang, Xiliang

    2014-01-01

    As the biggest carbon emitting sector which produces 44% of current national carbon emission in China, the coal-dominated power sector has a tremendous potential for CO2 mitigation in the next two decades. Renewable energy quota system is currently discussed as a potential future policy instrument for the power sector, which requires certain fraction of renewable energy in total power generation for each province and grid zone. The quantitative studies on renewable energy quota for China are ...

  17. Characterization of Hybrid Systems for Rural Electrification with Renewable Energies Using Geographic Information Systems (GIS)

    Energy Technology Data Exchange (ETDEWEB)

    Borda Angel, J. P.; Dominguez, J.; Amador, J.; Arribas, L.; Pinedo Pascua, I.

    2011-07-01

    The objective of this project is to redefine the algorithm of wind-diesel hybrid system implemented in IntiGIS. This methodology was developed by CIEMAT for the evaluation of rural electrification projects, comparing different renewable and conventional technologies based on their LEC or equivalent electrification cost. The analysis considers the social and geographical particularities of the study area. The core of the new model is the definition of renewable fraction in the wind-diesel hybrid system. To this end, it was assumed that the fraction of renewable will depend, first of all, of the wind speed. In this case, the objectives were to find a relationship between the renewable fraction and wind speed, expressed as a function, and also trying to demonstrate the influence of other parameters such as fuel price and consumption. The methodology used to achieve these objectives was to use HOMER to simulate technology and size of system components in order to obtain the optimal fraction renewable scenarios. Next, we examined how it varied with wind speed; we assessed the influence of other parameters and, finally, it is represented as a function of wind speed. After the redefinition of the algorithm, the changes were planned for inclusion in IntiGIS and tests were performed to validate the new model. (Author)

  18. Energy Production System Management - Renewable energy power supply integration with Building Automation System

    Energy Technology Data Exchange (ETDEWEB)

    Figueiredo, Joao [Centre of Mechatronics Engineering - CEM/Institut of Mechanical Engineering - IDMEC, University of Evora, R. Romao Ramalho, 59, 7000-671 Evora (Portugal); Martins, Joao [Centre of Technology and Systems/Faculdade de Ciencias e Tecnologia, Universidade Nova Lisboa, 1049-001 Lisboa (Portugal)

    2010-06-15

    Intelligent buildings, historically and technologically, refers to the integration of four distinctive systems: Building Automation Systems (BAS), Telecommunication Systems, Office Automation Systems and Computer Building Management Systems. The increasing sophisticated BAS has become the ''heart and soul'' of modern intelligent buildings. Integrating energy supply and demand elements - often known as Demand-Side Management (DSM) - has became an important energy efficiency policy concept. Nowadays, European countries have diversified their power supplies, reducing the dependence on OPEC, and developing a broader mix of energy sources maximizing the use of renewable energy domestic sources. In this way it makes sense to include a fifth system into the intelligent building group: Energy Production System Management (EPSM). This paper presents a Building Automation System where the Demand-Side Management is fully integrated with the building's Energy Production System, which incorporates a complete set of renewable energy production and storage systems. (author)

  19. A Stochastic Calculus for Network Systems with Renewable Energy Sources

    CERN Document Server

    Wu, Kui; Marinakis, Dimitri

    2011-01-01

    We consider the performance modeling and evaluation of network systems powered with renewable energy sources such as solar and wind energy. Such energy sources largely depend on environmental conditions, which are hard to predict accurately. As such, it may only make sense to require the network systems to support a soft quality of service (QoS) guarantee, i.e., to guarantee a service requirement with a certain high probability. In this paper, we intend to build a solid mathematical foundation to help better understand the stochastic energy constraint and the inherent correlation between QoS and the uncertain energy supply. We utilize a calculus approach to model the cumulative amount of charged energy and the cumulative amount of consumed energy. We derive upper and lower bounds on the remaining energy level based on a stochastic energy charging rate and a stochastic energy discharging rate. By building the bridge between energy consumption and task execution (i.e., service), we study the QoS guarantee under...

  20. The first step towards a 100% renewable energy-system for Ireland

    DEFF Research Database (Denmark)

    Connolly, D.; Lund, Henrik; Mathiesen, Brian Vad;

    2011-01-01

    In 2007 Ireland supplied 96% of the total energy demand with fossil fuels (7% domestic and 89% imported) and 3% with renewable energy, even though there are enough renewable resources to supply all the energy required. As energy prices increase and the effects of global warming worsen......, it is essential that Ireland begins to utilise its renewable resources more effectively. Therefore, this study presents the first step towards a 100% renewable energy-system for Ireland. The energy-system analysis tool used was EnergyPLAN, as it accounts for all sectors of the energy-system that need...... resource: biomass, hydrogen, and electricity. These energy-systems were compared so that the benefits from each could be used to create an ‘optimum’ scenario called combination. Although the results illustrate a potential 100% renewable energy-system for Ireland, they have been obtained based on numerous...

  1. Technological Decision to Renewable Energy Usage Biogas for Off-grid Systems Consumption

    Directory of Open Access Journals (Sweden)

    Zubkova Marina

    2016-01-01

    Full Text Available This paper presents the results of the energy experiments based on electrochemical researches and the thermodynamic calculations, which are carried out on the hydrogenous fuel with the residual content of methane obtained from biogas selected organic waste. Energy indicators are examined in comparison to electrolysis hydrogen. The use of technical and electro physical indicators together with parameters of the fuel operating allowed assessing energy efficiency the module reformer - fuel cell running on a non-standard hydrogenous fuel. Numerical characteristic the efficiency of workflows fuel system reformer – fuel cell is about 39%. To operate the power installation with a predetermined capacity amount used of hydrogenous fuel is comparable to required electrolysis hydrogen amount. Shown the possibility of creation the systems of power supply based on new hydrogen technologies using renewable energy resources local waste. Confirms the relatively high efficiency the usage of hydrogenous fuel for the tasks of off-grid systems consumption.

  2. Fine-tuning Hematopoiesis: Microenvironmental factors regulating self-renewal and differentiation of hematopoietic stem cells

    NARCIS (Netherlands)

    T.C. Luis (Tiago)

    2010-01-01

    markdownabstract__Abstract__ Hematopoietic stem cells (HSCs) have the ability to self renew and generate all lineages of blood cells. Although it is currently well established that hematopoietic stem cells (HSCs) regenerate the blood compartment, it was only in the 1960s that was introduced the not

  3. Lhx2 expression promotes self-renewal of a distinct multipotential hematopoietic progenitor cell in embryonic stem cell-derived embryoid bodies.

    Directory of Open Access Journals (Sweden)

    Lina Dahl

    Full Text Available The molecular mechanisms regulating the expansion of the hematopoietic system including hematopoietic stem cells (HSCs in the fetal liver during embryonic development are largely unknown. The LIM-homeobox gene Lhx2 is a candidate regulator of fetal hematopoiesis since it is expressed in the fetal liver and Lhx2(-/- mice die in utero due to severe anemia. Moreover, expression of Lhx2 in embryonic stem (ES cell-derived embryoid bodies (EBs can lead to the generation of HSC-like cell lines. To further define the role of this transcription factor in hematopoietic regulation, we generated ES cell lines that enabled tet-inducible expression of Lhx2. Using this approach we observed that Lhx2 expression synergises with specific signalling pathways, resulting in increased frequency of colony forming cells in developing EB cells. The increase in growth factor-responsive progenitor cells directly correlates to the efficiency in generating HSC-like cell lines, suggesting that Lhx2 expression induce self-renewal of a distinct multipotential hematopoietic progenitor cell in EBs. Signalling via the c-kit tyrosine kinase receptor and the gp130 signal transducer by IL-6 is necessary and sufficient for the Lhx2 induced self-renewal. While inducing self-renewal of multipotential progenitor cells, expression of Lhx2 inhibited proliferation of primitive erythroid precursor cells and interfered with early ES cell commitment, indicating striking lineage specificity of this effect.

  4. A single cell bioengineering approach to elucidate mechanisms of adult stem cell self-renewal.

    Science.gov (United States)

    Gilbert, Penney M; Corbel, Stephane; Doyonnas, Regis; Havenstrite, Karen; Magnusson, Klas E G; Blau, Helen M

    2012-04-01

    The goal of regenerative medicine is to restore form and function to damaged and aging tissues. Adult stem cells, present in tissues such as skeletal muscle, comprise a reservoir of cells with a remarkable capacity to proliferate and repair tissue damage. Muscle stem cells, known as satellite cells, reside in a quiescent state in an anatomically distinct compartment, or niche, ensheathed between the membrane of the myofiber and the basal lamina. Recently, procedures for isolating satellite cells were developed and experiments testing their function upon transplantation into muscles revealed an extraordinary potential to contribute to muscle fibers and access and replenish the satellite cell compartment. However, these properties are rapidly lost once satellite cells are plated in culture. Accordingly, elucidating the role of extrinsic factors in controlling muscle stem cell fate, in particular self-renewal, is critical. Through careful design of bioengineered culture platforms, analysis of specific proteins presented to stem cells is possible. Critical to the success of the approach is single cell analysis, as more rapidly proliferating progenitors may mask the behavior of stem cells that proliferate slowly. Bioengineering approaches provide a potent means of gaining insight into the role of extrinsic factors in the stem cell microenvironment on stem cell function and the mechanisms that control their diverse fates. Ultimately, the multidisciplinary approach presented here will lead to novel therapeutic strategies for degenerative diseases.

  5. Renewable building energy systems and passive human comfort solutions

    Energy Technology Data Exchange (ETDEWEB)

    Omer, Abdeen Mustafa [17 Juniper Court, Forest Road West, Nottingham NG7 4EU (United Kingdom)

    2008-08-15

    With environmental protection posing as the number one global problem, man has no choice but to reduce his energy consumption. One way to accomplish this is to resort to passive and low-energy systems to maintain thermal comfort in buildings. The conventional and modern designs of wind towers can successfully be used in hot arid regions to maintain thermal comfort (with or without the use of ceiling fans) during all hours of the cooling season, or a fraction of it. Climatic design is one of the best approaches to reduce the energy cost in buildings. Proper design is the first step of defence against the stress of the climate. Buildings should be designed according to the climate of the site, reducing the need for mechanical heating or cooling. Hence maximum natural energy can be used for creating a pleasant environment inside the built envelope. Technology and industry progress in the last decade diffused electronic and informatics' devices in many human activities, and also in building construction. The utilisation and operating opportunities components, increase the reduction of heat losses by varying the thermal insulation, optimise the lighting distribution with louver screens and operate mechanical ventilation for coolness in indoor spaces. In addition to these parameters the intelligent envelope can act for security control and became an important part of the building domotic revolution. Application of simple passive cooling measure is effective in reducing the cooling load of buildings in hot and humid climates. Fourty-three percent reductions can be achieved using a combination of well-established technologies such as glazing, shading, insulation, and natural ventilation. More advanced passive cooling techniques such as roof pond, dynamic insulation, and evaporative water jacket need to be considered more closely. The building sector is a major consumer of both energy and materials worldwide, and that consumption is increasing. Most industrialised

  6. Markov Renewal Methods in Restart Problems in Complex Systems

    DEFF Research Database (Denmark)

    Asmussen, Søren; Lipsky, Lester; Thompson, Stephen

    A task with ideal execution time L such as the execution of a computer program or the transmission of a file on a data link may fail, and the task then needs to be restarted. The task is handled by a complex system with features similar to the ones in classical reliability: failures may...... be mitigated by using server redundancy in parallel or k-out-of-n arrangements, standbys may be cold or warm, one or more repairmen may take care of failed components, etc. The total task time X (including restarts and pauses in failed states) is investigated with particular emphasis on the tail P(X > x......). A general alternating Markov renewal model is proposed and an asymptotic exponential form P(X > x) ∼ Ce−γx identified for the case of a deterministic task time L ≡ `. The rate γ is given by equating the spectral radius of a certain matrix to 1, and the asymptotic form of γ = γ(`) as ` → ∞ is derived...

  7. The regulation of self-renewal in human embryonic stem cells.

    Science.gov (United States)

    Avery, Stuart; Inniss, Katie; Moore, Harry

    2006-10-01

    Human embryonic stem (hES) cells have the ability to self-renew while maintaining their pluripotency. The ability of stem cells to self-renew expansively is essential in both development and maintenance of adult tissues. ES cell lines were first generated from mouse blastocysts, these lines provided much needed information regarding ES cell propagation, growth factor dependence, and marker expression. However, the application potential of murine models is restricted in value because many differences between mouse and human ES cells have since been identified. The process of hES cells self-renewal appears to be regulated by many different pathways; however, the molecular mechanisms enabling this process are not fully characterized. Further defining these mechanisms will enable growth of hES cells under defined conditions and aid controlled differentiation of cells into specified lineages, in turn providing cells suitable for therapeutic applications. This review provides a summary of the mechanisms known to control self-renewal and pluripotency in hES cells.

  8. Fuel Consumption Analysis and Optimization of a Sustainable Energy System for a 100% Renewables Smart House

    DEFF Research Database (Denmark)

    Craciun, Vasile Simion; Blarke, Morten; Trifa, Viorel

    2012-01-01

    . In case of renewable energies, one main challenge is the discontinuity of generation which can be solved with planning and control optimization methods. The results of the economic analysis and the feasibility of the sustainable energy system for a 100% renewables SH show that this could be possible...

  9. Assesment of Emerging Renewable Energy-based Cogeneration Systems for nZEB Residential Buildings

    DEFF Research Database (Denmark)

    Carmo, Carolina; Dumont, Olivier; Nielsen, Mads Pagh

    2016-01-01

    technologies based on renewable energy sources has increased tremendously in the last decade. A significant amount of experimental and modelling research has recently been presented on emerging technologies. In this paper, four main technologies are assessed: Fuel Cells (FC), Photovoltaic thermal (PV/T), solar...... thermal reversible heat pump /organic Rankine cycle (HP/ORC) and cogeneration solar Thermoelectric generators (TEG). This paper aims to give an overview of the state-of-the-art developments, discuss the fundamental and technical challenges facing commercial adoption and prospects of these technologies......Net Zero Energy Buildings (nZEB) imply reduced consumption by means of good insulation, passive strategies and highly efficient energy supply systems. Among others, micro cogeneration systems are considered as one of the system solutions with the highest potential to enable nZEB. These systems...

  10. Roles of TGF-β family signaling in stem cell renewal and differentiation

    Institute of Scientific and Technical Information of China (English)

    Tetsuro Watabe; Kohei Miyazono

    2009-01-01

    Transforming growth factor(TGF)-βs and their family members,including bone morphogenetic proteins(BMPs),Nodal and acfivins.have been implicated in the development and maintenance of various organs,in which stem cells play important roles.Stem cells are characterized by their ability to seif-renew and to generate differentiated cells of a particular tissue.and are classifed into embryonic and somatic stem cells.Embryonic stem(ES)cells self-renew indefinitely and contribute to derivafives of all three primary germ layers.in contrast,somatic stem cells,which can be identified in various adult organs.exhibit Iimited abilities for self-renewal and differentiation in most cases.The multi-lineage differentiation capacity of ES cells and somatic stem cells has opened possibilities for cell replacement therapies for genetic.malignant and degenerative diseases.In order to utilize stem cells for therapeutic applications,it is essential to understand the extrinsic and intrinsic factors regulating self-renewal and differentiation of stem cells.More recently,induced pluripotent stem(iPS)cells have been generated from mouse and human fibroblasts that re-semble ES cells via ectopic expression of four transcription factors.iPS cells may have an advantage in regenerative medicine,since they overcome the immunogenicity and ethical controversy of ES cells.Moreover,recent studies have highlighted the involvement of cancer stem cells during the formation and progression of various types of cancers,including leukemia,glioma,and breast cancer.Here,we illustrate the roles of TGF-β family members in the mainte-nance and differentiation of ES cells,somatic stem cells,and cancer stem cells.

  11. A Review of Hybrid Renewable Energy Systems for Electric Power Generation

    OpenAIRE

    Md. Ibrahim; Abul Khair

    2015-01-01

    Integration and combined utilization of renewable energy sources are becoming increasingly attractive. This paper is a review of hybrid renewable energy systems technologies for power generation, important issues and challenges in their design stage. Generation technology selection and unit sizing, System configurations and Energy management and control are discussed. Applications of hybrid energy systems, advantages of hybrid energy systems, issues and problems related to hybrid ...

  12. The molecular mechanism of embryonic stem cell pluripotency and self-renewal

    Institute of Scientific and Technical Information of China (English)

    LIU; YuXiao; JI; Lei; TEN; Yue; WANG; YunFang; PEI; XueTao

    2007-01-01

    The self-renewal and pluripotency of embryonic stem cells (ESCs) is regulated by a network, which consists of a series of cell factors in microenviroments, a chain of transcription factors and certain signal conduction pathways. This article reviews recent progress in this field to elucidate the mechanism involved.

  13. Targeting ROR1 inhibits the self-renewal and invasive ability of glioblastoma stem cells.

    Science.gov (United States)

    Jung, Eun-Hwa; Lee, Han-Na; Han, Gi-Yeon; Kim, Min-Jung; Kim, Chan-Wha

    2016-04-01

    Glioblastoma is the most malignant of brain tumours and is difficult to cure because of interruption of drug delivery by the blood-brain barrier system, its high metastatic capacity and the existence of cancer stem cells (CSCs). Although CSCs are present as a small population in malignant tumours, CSCs have been studied as they are responsible for causing recurrence, metastasis and resistance to chemotherapy and radiotherapy for cancer. CSCs have self-renewal characteristics like normal stem cells. The aim of this study was to investigate whether receptor tyrosine kinase-like orphan receptor 1 (ROR1) is involved in stem cell maintenance and malignant properties in human glioblastoma. Knockdown of ROR1 caused reduction of stemness and sphere formation capacity. Moreover, down-regulation of ROR1 suppressed the expression of epithelial-mesenchymal transition-related genes and the tumour migratory and invasive abilities. The results of this study indicate that targeting ROR1 can induce differentiation of CSCs and inhibit metastasis in glioblastoma. In addition, ROR1 may be used as a potential marker for glioblastoma stem cells as well as a potential target for glioblastoma stem cell therapy.

  14. Optimal configuration of power generating systems in isolated island with renewable energy

    Energy Technology Data Exchange (ETDEWEB)

    Senjyu, Tomonobu; Hayashi, Daisuke; Yona, Atsushi; Urasaki, Naomitsu [Faculty of Engineering, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Nakagami, Okinawa 903-0213 (Japan); Funabashi, Toshihisa [Meidensha Corporation, 36-2 Nihonbashi Hakozakicho, Chuo-ku, Tokyo 103-8515 (Japan)

    2007-09-15

    In isolated islands, usually diesel generators supply electric power. However, there are problems, e.g., a lack of fossil fuel, environmental pollution etc. So, isolated island, e.g. Miyako island, installs renewable energy power production plants. However, renewable energy power production plants are very costly. This paper presents an optimal configuration of power system in isolated island installing renewable energy power production plants. The generating system consists of diesel generators, wind turbine generators, PV system and batteries. Using the proposed method, operation cost can be reduced about 10% in comparison with diesel generators only from simulation results. (author)

  15. Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control.

    Science.gov (United States)

    Clevers, Hans; Loh, Kyle M; Nusse, Roel

    2014-10-03

    Stem cells fuel tissue development, renewal, and regeneration, and these activities are controlled by the local stem cell microenvironment, the "niche." Wnt signals emanating from the niche can act as self-renewal factors for stem cells in multiple mammalian tissues. Wnt proteins are lipid-modified, which constrains them to act as short-range cellular signals. The locality of Wnt signaling dictates that stem cells exiting the Wnt signaling domain differentiate, spatially delimiting the niche in certain tissues. In some instances, stem cells may act as or generate their own niche, enabling the self-organization of patterned tissues. In this Review, we discuss the various ways by which Wnt operates in stem cell control and, in doing so, identify an integral program for tissue renewal and regeneration.

  16. A High-Efficiency Voltage Equalization Scheme for Supercapacitor Energy Storage System in Renewable Generation Applications

    Directory of Open Access Journals (Sweden)

    Liran Li

    2016-06-01

    Full Text Available Due to its fast charge and discharge rate, a supercapacitor-based energy storage system is especially suitable for power smoothing in renewable energy generation applications. Voltage equalization is essential for series-connected supercapacitors in an energy storage system, because it supports the system’s sustainability and maximizes the available cell energy. In this paper, we present a high-efficiency voltage equalization scheme for supercapacitor energy storage systems in renewable generation applications. We propose an improved isolated converter topology that uses a multi-winding transformer. An improved push-pull forward circuit is applied on the primary side of the transformer. A coupling inductor is added on the primary side to allow the switches to operate under the zero-voltage switching (ZVS condition, which reduces switching losses. The diodes in the rectifier are replaced with metal-oxide-semiconductor field-effect transistors (MOSFETs to reduce the power dissipation of the secondary side. In order to simplify the control, we designed a controllable rectifying circuit to achieve synchronous rectifying on the secondary side of the transformer. The experimental results verified the effectiveness of the proposed design.

  17. Energy efficiency and renewable energy systems in Portugal and Brazil

    DEFF Research Database (Denmark)

    Østergaard, Poul Alberg; Soares, Isabel; Ferreira, Paula

    2014-01-01

    This article presents a review of the energy situation in Brazil and Portugal; two countries which are both characterised by high utilisation of renewable energy sources though with differences between them. The article also introduces contemporary energy research conducted on the two countries...

  18. The integration of renewable energy sources into electric power transmission systems

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, P.R.; Dykas, W.P.; Kirby, B.J.; Purucker, S.L. [Oak Ridge National Lab., TN (United States); Lawler, J.S. [Univ. of Tennessee, Knoxville, TN (United States)

    1995-07-01

    Renewable energy technologies such as photovoltaics, solar thermal power plants, and wind turbines are nonconventional, environmentally attractive sources of energy that can be considered for electric power generation. Many of the areas with abundant renewable energy resources (very sunny or windy areas) are far removed from major load centers. Although electrical power can be transmitted over long distances of many hundreds of miles through high-voltage transmission lines, power transmission systems often operate near their limits with little excess capacity for new generation sources. This study assesses the available capacity of transmission systems in designated abundant renewable energy resource regions and identifies the requirements for high-capacity plant integration in selected cases. In general, about 50 MW of power from renewable sources can be integrated into existing transmission systems to supply local loads without transmission upgrades beyond the construction of a substation to connect to the grid. Except in the Southwest, significant investment to strengthen transmission systems will be required to support the development of high-capacity renewable sources of 1000 MW or greater in areas remote from major load centers. Cost estimates for new transmission facilities to integrate and dispatch some of these high-capacity renewable sources ranged from several million dollars to approximately one billion dollars, with the latter figure an increase in total investment of 35%, assuming that the renewable source is the only user of the transmission facility.

  19. Design, Engineering, and Construction of Photosynthetic Microbial Cell Factories for Renewable Solar Fuel Production

    Energy Technology Data Exchange (ETDEWEB)

    Lindblad, Peter; Lindberg, Pia; Stensjoe, Karin (Photochemistry and Molecular Science, Dept. of Chemistry-Aangstroem Laboratory, Uppsala Univ., Uppsala (Sweden)), E-mail: Peter.Lindblad@kemi.uu.se; Oliveira, Paulo (Instituto de Biologia Molecular e Celular, Porto (Portugal)); Heidorn, Thorsten (Bioforsk-Norwegian Inst. for Agricultural and Environmental Research, Aas Oslo, (Norway))

    2012-03-15

    There is an urgent need to develop sustainable solutions to convert solar energy into energy carriers used in the society. In addition to solar cells generating electricity, there are several options to generate solar fuels. This paper outlines and discusses the design and engineering of photosynthetic microbial systems for the generation of renewable solar fuels, with a focus on cyanobacteria. Cyanobacteria are prokaryotic microorganisms with the same type of photosynthesis as higher plants. Native and engineered cyanobacteria have been used by us and others as model systems to examine, demonstrate, and develop photobiological H{sub 2} production. More recently, the production of carbon-containing solar fuels like ethanol, butanol, and isoprene have been demonstrated. We are using a synthetic biology approach to develop efficient photosynthetic microbial cell factories for direct generation of biofuels from solar energy. Present progress and advances in the design, engineering, and construction of such cyanobacterial cells for the generation of a portfolio of solar fuels, e.g., hydrogen, alcohols, and isoprene, are presented and discussed. Possibilities and challenges when introducing and using synthetic biology are highlighted

  20. Human Capacity Building in Energy Efficiency and Renewable Energy System Maintenance for the Yurok Tribe

    Energy Technology Data Exchange (ETDEWEB)

    Engel, R. A.' Zoellick, J J.

    2007-07-31

    From July 2005 to July 2007, the Schatz Energy Research Center (SERC) assisted the Yurok Tribe in the implementation of a program designed to build the Tribe’s own capacity to improve energy efficiency and maintain and repair renewable energy systems in Tribal homes on the Yurok Reservation. Funding for this effort was provided by the U.S. Department of Energy’s Tribal Program under First Steps grant award #DE-FG36-05GO15166. The program’s centerpiece was a house-by-house needs assessment, in which Tribal staff visited and conducted energy audits at over fifty homes. The visits included assessment of household energy efficiency and condition of existing renewable energy systems. Staff also provided energy education to residents, evaluated potential sites for new household renewable energy systems, and performed minor repairs as needed on renewable energy systems.

  1. The Integration of Sustainable Transport into Future Renewable Energy Systems in China

    DEFF Research Database (Denmark)

    Liu, Wen

    use are largely lost in the current fossil fuel dominated energy systems. Sustainable transport development requires solutions from an overall renewable energy system in which integration of large-scale intermittent renewable energy needs assistance. Technologies of alternative vehicle fuels...... in transport may play a role in furthering such integration. The objective of this research is to make a contribution to the development of methodologies to identify and develop future sustainable transport systems as well as to apply such methodologies to the case of China. In particular, the methodological...... development focuses on 1) identifying suitable transport technologies and strategies based on renewable energy and 2) evaluating such technologies from the perspective of overall renewable energy system integration. For this purpose, a methodological framework involving the research fields of both...

  2. A DSP based power electronics interface for alternative /renewable energy system.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-09-28

    This report is an update on the research project involving the implementation of a DSP-based power electronics interface for alternate/renewable energy systems, that was funded by the Department of Energy under the Inventions and Innovations program.

  3. Renewable Energy Powered Membrane Technology. 1. Development and Characterization of a Photovoltaic Hybrid Membrane System

    OpenAIRE

    Schaefer, Andrea; Broeckmann, A.; Richards, B.S.

    2007-01-01

    In isolated communities where potable water sources as well as energy grids are limited or nonexistent, treating brackish groundwater aquifers with small-scale desalination systems can be a viable alternative to existing water infrastructures. Given the unavailability of power in many such situations, renewable energy is an obvious solution to power such systems. However, renewable energy is an intermittent power supply and with regards to the performance of intermittently operated desalinati...

  4. Definition of a remuneration system for heat from renewable resources; Ausgestaltung einer Einspeiseverguetung fuer erneuerbare Waerme

    Energy Technology Data Exchange (ETDEWEB)

    Dettli, R.; Ott, W.; Philippen, D.; Umbricht, A.

    2009-06-15

    This report for the Swiss Federal Office of Energy (SFOE) deals with proposals for a remuneration system for heat obtained from renewable resources. Local and regional district heating systems cover around three percent of Swiss heating needs. The authors estimate that, if these systems were to be operated completely using renewable resources such as biomass, ambient heat and the renewable portion of heat from waste incineration, around seven per cent of needs could be met. Further, around 10,000 heating systems with a power of more than 350 kW could be operated with renewables. A further potential for the use of renewable heating resources can be found in wastewater treatment plants and industrial waste heat. Various obstacles and restraints on the use of renewable resources in the heating area are discussed. The idea of providing a cost-covering remuneration system for heat is discussed and compared with that for renewable electricity. The proposed system is discussed, which would provide investment subsidies, risk-coverage and project development subsidies. The report discusses the results of a market analysis and the differences to be found between the markets for electricity and heat. Existing promotional programs are noted and the aims of a possible remuneration system are discussed. A concept for a promotion program for renewable heat generation and the use of waste heat is introduced. The installations to be promoted and the amount of remuneration to be paid out are discussed. Finally, the costs and the effects of the proposed promotion scheme are discussed. A comprehensive appendix provides details on the proposed system and provides information on market volume, energy resources, networks and infrastructure, providers of heat energy, heat consumers and general conditions as far as factors such as pricing and legislation are concerned. Finally, the 'Climate Cent' foundation is commented on.

  5. REST controls self-renewal and tumorigenic competence of human glioblastoma cells.

    Science.gov (United States)

    Conti, Luciano; Crisafulli, Laura; Caldera, Valentina; Tortoreto, Monica; Brilli, Elisa; Conforti, Paola; Zunino, Franco; Magrassi, Lorenzo; Schiffer, Davide; Cattaneo, Elena

    2012-01-01

    The Repressor Element 1 Silencing Transcription factor (REST/NRSF) is a master repressor of neuronal programs in non-neuronal lineages shown to function as a central regulator of developmental programs and stem cell physiology. Aberrant REST function has been associated with a number of pathological conditions. In cancer biology, REST has been shown to play a tumor suppressor activity in epithelial cancers but an oncogenic role in brain childhood malignancies such as neuroblastoma and medulloblastoma. Here we examined REST expression in human glioblastoma multiforme (GBM) specimens and its role in GBM cells carrying self-renewal and tumorigenic competence. We found REST to be expressed in GBM specimens, its presence being particularly enriched in tumor cells in the perivascular compartment. Significantly, REST is highly expressed in self-renewing tumorigenic-competent GBM cells and its knock down strongly reduces their self-renewal in vitro and tumor-initiating capacity in vivo and affects levels of miR-124 and its downstream targets. These results indicate that REST contributes to GBM maintenance by affecting its self-renewing and tumorigenic cellular component and that, hence, a better understanding of these circuitries in these cells might lead to new exploitable therapeutic targets.

  6. Power electronics for renewable energy systems, transportation and industrial applications

    CERN Document Server

    Malinowski, Mariusz; Al-Haddad, Kamal

    2014-01-01

    Power Electronics for Renewable Energy, Transportation, and Industrial Applications combines state-of-the-art global expertise to present the latest research on power electronics and its application in transportation, renewable energy, and different industrial applications. This timely book aims to facilitate the implementation of cutting-edge techniques to design problems offering innovative solutions to the growing power demands in small- and large-size industries. Application areas in the book range from smart homes and electric and plug-in hybrid electrical vehicles (PHEVs), to smart distribution and intelligence operation centers where significant energy efficiency improvements can be achieved through the appropriate use and design of power electronics and energy storage devices.

  7. Transmission needs across a fully renewable European power system

    CERN Document Server

    Rodriguez, Rolando A; Andresen, Gorm B; Heide, Dominik; Greiner, Martin

    2013-01-01

    The residual load and excess power generation of 27 European countries with a 100% penetration of variable renewable energy sources are explored in order to quantify the benefit of power transmission between countries. Estimates are based on extensive weather data, which allows for modelling of hourly mismatches between the demand and renewable generation from wind and solar photovoltaics. For separated countries, balancing is required to cover around 24% of the total annual energy consumption. This number can be reduced down to 15% once all countries are networked together with uncon- strained interconnectors. The reduction represents the maximum possible benefit of transmission for the countries. The total Net Transfer Capacity of the unconstrained interconnectors is roughly twelve times larger than current values. However, constrained interconnector capacities six times larger than the current values are found to provide 97% of the maximum possible benefit of cooperation. This motivates a detailed investig...

  8. Energy efficiency and renewable energy systems in Portugal and Brazil

    Directory of Open Access Journals (Sweden)

    Poul Alberg Østergaard

    2014-06-01

    Full Text Available This article presents a review of the energy situation in Brazil and Portugal; two countries which are both characterised by high utilisation of renewable energy sources though with differences between them. The article also introduces contemporary energy research conducted on the two countries and presented at The 1st International Congress on Energy & Environment ranging from electricity end-use analyses, electricity production analyses to socio-economic assessment and large-scale energy scenarios.

  9. Matching renewable energy systems to village-level energy needs

    Energy Technology Data Exchange (ETDEWEB)

    Ashworth, J.H.; Neuendorffer, J.W.

    1980-06-01

    This report provides a five step process for matching alternative renewable energy technologies with energy needs in rural villages of developing countries. Analytic tools are given for each of the five steps as well as information that can be expected. Twelve characterization criteria are developed to assist in the matching process. Three of these criteria, called discrimination criteria, are used for preliminary screening of technology possibilities for each need. The other criteria address site-specific temporal, climatic, social, cultural, and environmental characteristics of the energy need, technology, and cost considerations. To illustrate the matching process, seven basic human needs for energy are matched with seven potential renewable energy technologies. The final portion of the paper discusses the advantages of such a matching process and the resources required to initiate such an effort within a development project. Specific recommendations are given for field-testing this process and actions that could be taken immediately in basic research and development, applied research and technology modification, demonstrations, and commercialization to assist in the future diffusion of renewable energy technologies to rural areas of developing countries.

  10. Erk signaling suppresses embryonic stem cell self-renewal to specify endoderm

    DEFF Research Database (Denmark)

    Hamilton, William B; Brickman, Joshua M

    2014-01-01

    Fgf signaling via Erk activation has been associated with both neural induction and the generation of a primed state for the differentiation of embryonic stem cells (ESCs) to all somatic lineages. To dissect the role of Erk in both ESC self-renewal and lineage specification, we explored...

  11. Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate

    Directory of Open Access Journals (Sweden)

    Sofia Baptista

    2014-09-01

    Full Text Available Methamphetamine (METH is a highly addictive psychostimulant drug of abuse that negatively interferes with neurogenesis. In fact, we have previously shown that METH triggers stem/progenitor cell death and decreases neuronal differentiation in the dentate gyrus (DG. Still, little is known regarding its effect on DG stem cell properties. Herein, we investigate the impact of METH on mice DG stem/progenitor cell self-renewal functions. METH (10 nM decreased DG stem cell self-renewal, while 1 nM delayed cell cycle in the G0/G1-to-S phase transition and increased the number of quiescent cells (G0 phase, which correlated with a decrease in cyclin E, pEGFR and pERK1/2 protein levels. Importantly, both drug concentrations (1 or 10 nM did not induce cell death. In accordance with the impairment of self-renewal capacity, METH (10 nM decreased Sox2+/Sox2+ while increased Sox2−/Sox2− pairs of daughter cells. This effect relied on N-methyl-d-aspartate (NMDA signaling, which was prevented by the NMDA receptor antagonist, MK-801 (10 μM. Moreover, METH (10 nM increased doublecortin (DCX protein levels consistent with neuronal differentiation. In conclusion, METH alters DG stem cell properties by delaying cell cycle and decreasing self-renewal capacities, mechanisms that may contribute to DG neurogenesis impairment followed by cognitive deficits verified in METH consumers.

  12. Fuel Cell Electric Vehicle Evaluation; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, Jennifer; Sprik, Sam; Ainscough, Chris; Saur, Genevieve

    2015-06-10

    This presentation provides a summary of NREL's FY15 fuel cell electric vehicle evaluation project activities and accomplishments. It was presented at the U.S. Department of Energy Hydrogen and Fuel Cells Program 2015 Annual Merit Review and Peer Evaluation Meeting on June 10, 2015, in Arlington, Virginia.

  13. The p53 inhibitor, pifithrin-{alpha}, suppresses self-renewal of embryonic stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Abdelalim, Essam Mohamed, E-mail: essam_abdelalim@yahoo.com [Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192 (Japan); Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522 (Egypt); Tooyama, Ikuo [Molecular Neuroscience Research Center, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga 520-2192 (Japan)

    2012-04-13

    Highlights: Black-Right-Pointing-Pointer We determine the role of p53 in ES cells under unstressful conditions. Black-Right-Pointing-Pointer PFT-{alpha} suppresses ES cell proliferation. Black-Right-Pointing-Pointer PFT-{alpha} induces ES cell cycle arrest. Black-Right-Pointing-Pointer PFT-{alpha} downregulates Nanog and cyclin D1. -- Abstract: Recent studies have reported the role of p53 in suppressing the pluripotency of embryonic stem (ES) cells after DNA damage and blocking the reprogramming of somatic cells into induced pluripotent stem (iPS) cells. However, to date no evidence has been presented to support the function of p53 in unstressed ES cells. In this study, we investigated the effect of pifithrin (PFT)-{alpha}, an inhibitor of p53-dependent transcriptional activation, on self-renewal of ES cells. Our results revealed that treatment of ES cells with PFT-{alpha} resulted in the inhibition of ES cell propagation in a dose-dependent manner, as indicated by a marked reduction in the cell number and colony size. Also, PFT-{alpha} caused a cell cycle arrest and significant reduction in DNA synthesis. In addition, inhibition of p53 activity reduced the expression levels of cyclin D1 and Nanog. These findings indicate that p53 pathway in ES cells rather than acting as an inactive gene, is required for ES cell proliferation and self-renewal under unstressful conditions.

  14. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.

    Science.gov (United States)

    Sneddon, Julie B; Borowiak, Malgorzata; Melton, Douglas A

    2012-11-29

    One goal of regenerative medicine, to use stem cells to replace cells lost by injury or disease, depends on producing an excess of the relevant cell for study or transplantation. To this end, the stepwise differentiation of stem cells into specialized derivatives has been successful for some cell types, but a major problem remains the inefficient conversion of cells from one stage of differentiation to the next. If specialized cells are to be produced in large numbers it will be necessary to expand progenitor cells, without differentiation, at some steps of the process. Using the pancreatic lineage as a model for embryonic-stem-cell differentiation, we demonstrate that this is a solvable problem. Co-culture with organ-matched mesenchyme permits proliferation and self-renewal of progenitors, without differentiation, and enables an expansion of more than a million-fold for human endodermal cells with full retention of their developmental potential. This effect is specific both to the mesenchymal cell and to the progenitor being amplified. Progenitors that have been serially expanded on mesenchyme give rise to glucose-sensing, insulin-secreting cells when transplanted in vivo. Theoretically, the identification of stage-specific renewal signals can be incorporated into any scheme for the efficient production of large numbers of differentiated cells from stem cells and may therefore have wide application in regenerative biology.

  15. Impacts of Renewable Energy Quota System on China's Future Power Sector

    DEFF Research Database (Denmark)

    Xiong, Weiming; Zhang, Da; Mischke, Peggy

    2014-01-01

    As the biggest carbon emitting sector which produces 44% of current national carbon emission in China, the coal-dominated power sector has a tremendous potential for CO2 mitigation in the next two decades. Renewable energy quota system is currently discussed as a potential future policy instrument...... for the power sector, which requires certain fraction of renewable energy in total power generation for each province and grid zone. The quantitative studies on renewable energy quota for China are still very limited. Based on a least-cost and technology-rich power generation and transmission expansion model...... for China, this study examines the impacts of renewable energy quota system and carbon cap policy instruments on the future Chinese power sector. Various scenarios are examined toward 2030 and their future power generation mix, capacity installations and carbon emission are discussed. This study concludes...

  16. Planning of community-scale renewable energy management systems in a mixed stochastic and fuzzy environment

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Y.P.; Tan, Q. [Environmental Systems Engineering Program, Faculty of Engineering, Unversity of Regina, Regina, Saskatchewan (Canada); Huang, G.H. [Environmental Systems Engineering Program, Faculty of Engineering, Unversity of Regina, Regina, Saskatchewan (Canada)]|[Chinese Research Academy of Environmental Science, Beijing Normal University, Beijing 100012-100875 (China); Yang, Z.F. [State Key Laboratory of Water Environment Simulation, School of Enviroment, Beijing Normal University, Beijing 100875 (China)

    2009-07-15

    In this study, an interval-parameter superiority-inferiority-based two-stage programming model has been developed for supporting community-scale renewable energy management (ISITSP-CREM). This method is based on an integration of the existing interval linear programming (ILP), two-stage programming (TSP) and superiority-inferiority-based fuzzy-stochastic programming (SI-FSP). It allows uncertainties presented as both probability/possibilistic distributions and interval values to be incorporated within a general optimization framework, facilitating the reflection of multiple uncertainties and complexities during the process of renewable energy management systems planning. ISITSP-CREM can also be used for effectively addressing dynamic interrelationships between renewable energy availabilities, economic penalties and electricity-generation deficiencies within a community scale. Thus, complexities in renewable energy management systems can be systematically reflected, highly enhancing applicability of the modeling process. The developed method has then been applied to a case of long-term renewable energy management planning for three communities. Useful solutions for the planning of renewable energy management systems have been generated. Interval solutions associated with different energy availabilities and economic penalties have been obtained. They can be used for generating decision alternatives and thus help decision makers identify desired policies under various economic and system-reliability constraints. The generated solutions can also provide desired energy resource/service allocation plans with a minimized system cost (or economic penalties), a maximized system reliability level and a maximized energy security. Tradeoffs between system costs and energy security can also be tackled. Higher costs will increase potential energy generation amount, while a desire for lower system costs will run into a risk of energy deficiency. They are helpful for supporting

  17. Model for energy conversion in renewable energy system with hydrogen storage

    Science.gov (United States)

    Kélouwani, S.; Agbossou, K.; Chahine, R.

    A dynamic model for a stand-alone renewable energy system with hydrogen storage (RESHS) is developed. In this system, surplus energy available from a photovoltaic array and a wind turbine generator is stored in the form of hydrogen, produced via an electrolyzer. When the energy production from the wind turbine and the photovoltaic array is not enough to meet the load demand, the stored hydrogen can then be converted by a fuel cell to produce electricity. In this system, batteries are used as energy buffers or for short time storage. To study the behavior of such a system, a complete model is developed by integrating individual sub-models of the fuel cell, the electrolyzer, the power conditioning units, the hydrogen storage system, and the batteries (used as an energy buffer). The sub-models are valid for transient and steady state analysis as a function of voltage, current, and temperature. A comparison between experimental measurements and simulation results is given. The model is useful for building effective algorithms for the management, control and optimization of stand-alone RESHSs.

  18. Organizational precedents for ownership and management of decentralized renewable-energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Meunier, R.; Silversmith, J.A.

    1981-03-01

    Three existing organizational types that meet the decentralization criteria of local consumer ownership and control - cooperatives, Rural Electric Cooperatives, and municipal utilities - are examined. These three organizational precedents are analyzed in terms of their histories, structures, legal powers, sources of capital, and social and political aspects. Examples of related experiments with renewable energy technologies are given, and inferences are drawn regarding the organizations' suitability as vehicles for future implementation of decentralized renewable energy systems.

  19. Second life battery energy storage system for enhancing renewable energy grid integration

    OpenAIRE

    Koch-Ciobotaru, Cosmin; Saez-de Ibarra, Andoni; Martinez-Laserna, Egoitz; Stroe, Daniel-Ioan; Swierczynski, Maciej; Rodríguez Cortés, Pedro

    2015-01-01

    Connecting renewable power plants to the grid must comply with certain codes and requirements. One requirement is the ramp rate constraint, which must be fulfilled in order to avoid penalties. As this service becomes compulsory with an increased grid penetration of renewable, all possible solutions must be explored especially that large battery energy storage systems are still expensive solutions. Thus, in order to make battery investment economic viable, the use of second life batteries is i...

  20. Renewable energy resources for distributed generation systems in South Africa

    Energy Technology Data Exchange (ETDEWEB)

    Szewczuk, Stefan

    2010-09-15

    The South African Government has objective to provide universal access of electricity for its citizens and its electrification programme has been successful but focus has moved from numbers of connections to one of achieving sustainable socio-economic benefits. First-hand understanding was obtained of the complexity of socio-economic development where CSIR undertook a project in the rural areas of South Africa to identify electrification opportunities using renewable energy linked to economic activities. Lessons formed basis of a government funding implementation of pilot hybrid mini-grids to inform a future rollout. Results informed the development of distributed generation concepts and an integrated methodology.

  1. Regulation of embryonic stem cell self-renewal and differentiation by TGF-β family signaling

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Embryonic stem (ES) cells are characterized by their ability to indefinitely self-renew and potential to differentiate into all the cell lineages of the body. ES cells are considered to have potential applications in regenerative medicine. In particular, the emergence of an ES cell analogue-induced pluripotent stem (iPS) cells via somatic cell reprogramming by co-expressing a limited number of critical stemness-related transcriptional factors has solved the problem of obtaining patient-specific pluripotent cells, encouraging researchers to develop more specific and functional cell lineages from ES or iPS cells for broad therapeutic applications. ES cell fate choice is delicately controlled by a core transcriptional network, epigenetic modification profiles and complex signaling cascades both intrinsically and extrinsically. Of these signals, transforming growth factor β (TGF-β) family members, including TGF-β, bone morphogenetic protein (BMP), Activin and Nodal, have been reported to influence cell self-renewal and a broad spectrum of lineage differentiation in ES cells, in accordance with the key roles of TGF-β family signaling in early embryo development. In this review, the roles of TGF-β family signals in coordinating ES cell fate determination are summarized.

  2. Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation.

    Science.gov (United States)

    Kubota, Hiroshi; Avarbock, Mary R; Schmidt, Jonathan A; Brinster, Ralph L

    2009-08-01

    Loss-of-function mutation of the Kit gene causes a severe defect in spermatogenesis that results in infertility due to the inability of its cognate ligand, KIT ligand (KITL), to stimulate spermatogonial proliferation and differentiation. Although self-renewal of mouse spermatogonial stem cells (SSCs) depends on glial cell line-derived neurotrophic factor (GDNF), there is no unequivocal evidence that SSCs with a KIT deficiency can self-renew in vivo or in vitro. In the testis of W(v)/W(v) mice, in which the KIT tyrosine kinase activity is impaired, spermatogonia with SSC phenotype were identified. When W(v)/W(v) spermatogonia were cultured in an SSC culture system supplemented with GDNF in a 10% O(2) atmosphere, they formed clumps and proliferated continuously. An atmosphere of 10% O(2) was better than 21% O(2) to support SSC self-renewal. When W(v)/W(v) clump-forming germ cells were transplanted into testes of infertile wild-type busulfan-treated mice, they colonized the seminiferous tubules but did not differentiate. However, when transplanted into the testes of infertile W/W(v) pups, they restored spermatogenesis and produced spermatozoa, and progeny were generated using microinsemination. These results clearly show that SSCs exist in W(v)/W(v) testes and that they proliferate in vitro similar to wild-type SSCs, indicating that a functional KIT protein is not required for SSC self-renewal. Furthermore, the results indicate that a defect of KIT/KITL signaling of W(v)/W(v) SSCs does not prevent spermatogonial differentiation and spermatogenesis in some recipient strains.

  3. Design for micro-combined cooling, heating and power systems stirling engines and renewable power systems

    CERN Document Server

    2015-01-01

    ‘Design for Micro-Combined Cooling, Heating & Power Systems’ provides a manual for the technical and structural design of systems for supplying decentralised energy in residential buildings. It presents the micro-combined cooling, heating & power systems Stirling engines & renewable energy sources (mCCHP-SE-RES) systems in an accessible manner both for the public at large, and for professionals who conceive, design or commercialise such systems or their components.  The high performance levels of these systems are demonstrated within the final chapter by the results of an experiment in which a house is equipped with a mCCHP-SE-RES system. The reader is also familiarized with the conceptual, technical and legal aspects of modern domestic energy systems; the components that constitute these systems; and advanced algorithms for achieving the structural and technical design of such systems. In residential buildings, satisfying demands of durable development has gradually evolved from necessity to...

  4. On-Site Renewable Energy and Green Buildings: A System-Level Analysis.

    Science.gov (United States)

    Al-Ghamdi, Sami G; Bilec, Melissa M

    2016-05-03

    Adopting a green building rating system (GBRSs) that strongly considers use of renewable energy can have important environmental consequences, particularly in developing countries. In this paper, we studied on-site renewable energy and GBRSs at the system level to explore potential benefits and challenges. While we have focused on GBRSs, the findings can offer additional insight for renewable incentives across sectors. An energy model was built for 25 sites to compute the potential solar and wind power production on-site and available within the building footprint and regional climate. A life-cycle approach and cost analysis were then completed to analyze the environmental and economic impacts. Environmental impacts of renewable energy varied dramatically between sites, in some cases, the environmental benefits were limited despite the significant economic burden of those renewable systems on-site and vice versa. Our recommendation for GBRSs, and broader policies and regulations, is to require buildings with higher environmental impacts to achieve higher levels of energy performance and on-site renewable energy utilization, instead of fixed percentages.

  5. Efficient thermal desalination technologies with renewable energy systems: A state-of-the-art review

    Energy Technology Data Exchange (ETDEWEB)

    Esfahani, Iman Janghorban; Rashidi, Jouan; Ifaei, Pouya; Yoo, ChangKyoo [Center for Environmental Studies, Kyung Hee University, Yongin (Korea, Republic of)

    2016-02-15

    Due to the current fossil fuel crisis and associated adverse environmental impacts, renewable energy sources (RES) have drawn interest as alternatives to fossil fuels for powering water desalination systems. Over the last few decades the utility of renewable energy sources such as solar, geothermal, and wind to run desalination processes has been explored. However, the expansion of these technologies to larger scales is hampered by techno-economic and thermo-economic challenges. This paper reviews the state-of-the-art in the field of renewable energy-powered thermal desalination systems (RE-PTD) to compare their productivity and efficiency through thermodynamic, economic, and environmental analyses. We performed a comparative study using published data to classify RE-PTD systems technologies on the basis of the energy collection systems that they use. Among RE-PTD systems, solar energy powered-thermal desalination systems demonstrate high thermo-environ-economic efficiency to produce fresh water to meet various scales of demand.

  6. Stability Enhancement of a Power System Containing High-Penetration Intermittent Renewable Generation

    Directory of Open Access Journals (Sweden)

    Jorge Morel

    2015-06-01

    Full Text Available This paper considers the transient stability enhancement of a power system containing large amounts of solar and wind generation in Japan. Following the Fukushima Daiichi nuclear disaster there has been an increasing awareness on the importance of a distributed architecture, based mainly on renewable generation, for the Japanese power system. Also, the targets of CO2 emissions can now be approached without heavily depending on nuclear generation. Large amounts of renewable generation leads to a reduction in the total inertia of the system because renewable generators are connected to the grid by power converters, and transient stability becomes a significant issue. Simulation results show that sodium-sulfur batteries can keep the system in operation and stable after strong transient disturbances, especially for an isolated system. The results also show how the reduction of the inertia in the system can be mitigated by exploiting the kinetic energy of wind turbines.

  7. Photocatalysis for Renewable Energy Production Using PhotoFuelCells

    Directory of Open Access Journals (Sweden)

    Robert Michal

    2014-11-01

    Full Text Available The present work is a short review of our recent studies on PhotoFuelCells, that is, photoelectrochemical cells which consume a fuel to produce electricity or hydrogen, and presents some unpublished data concerning both electricity and hydrogen production. PhotoFuelCells have been constructed using nanoparticulate titania photoanodes and various cathode electrodes bearing a few different types of electrocatalyst. In the case where the cell functioned with an aerated cathode, the cathode electrode was made of carbon cloth carrying a carbon paste made of carbon black and dispersed Pt nanoparticles. When the cell was operated in the absence of oxygen, the electrocatalyst was deposited on an FTO slide using a special commercial carbon paste, which was again enriched with Pt nanoparticles. Mixing of Pt with carbon paste decreased the quantity of Pt necessary to act as electrocatalyst. PhotoFuelCells can produce electricity without bias and with relatively high open-circuit voltage when they function in the presence of fuel and with an aerated cathode. In that case, titania can be sensitized in the visible region by CdS quantum dots. In the present work, CdS was deposited by the SILAR method. Other metal chalcogenides are not functional as sensitizers because the combined photoanode in their presence does not have enough oxidative power to oxidize the fuel. Concerning hydrogen production, it was found that it is difficult to produce hydrogen in an alkaline environment even under bias, however, this is still possible if losses are minimized. One way to limit losses is to short-circuit anode and cathode electrode and put them close together. This is achieved in the “photoelectrocatalytic leaf”, which was presently demonstrated capable of producing hydrogen even in a strongly alkaline environment.

  8. Photocatalysis for renewable energy production using PhotoFuelCells.

    Science.gov (United States)

    Michal, Robert; Sfaelou, Stavroula; Lianos, Panagiotis

    2014-11-27

    The present work is a short review of our recent studies on PhotoFuelCells, that is, photoelectrochemical cells which consume a fuel to produce electricity or hydrogen, and presents some unpublished data concerning both electricity and hydrogen production. PhotoFuelCells have been constructed using nanoparticulate titania photoanodes and various cathode electrodes bearing a few different types of electrocatalyst. In the case where the cell functioned with an aerated cathode, the cathode electrode was made of carbon cloth carrying a carbon paste made of carbon black and dispersed Pt nanoparticles. When the cell was operated in the absence of oxygen, the electrocatalyst was deposited on an FTO slide using a special commercial carbon paste, which was again enriched with Pt nanoparticles. Mixing of Pt with carbon paste decreased the quantity of Pt necessary to act as electrocatalyst. PhotoFuelCells can produce electricity without bias and with relatively high open-circuit voltage when they function in the presence of fuel and with an aerated cathode. In that case, titania can be sensitized in the visible region by CdS quantum dots. In the present work, CdS was deposited by the SILAR method. Other metal chalcogenides are not functional as sensitizers because the combined photoanode in their presence does not have enough oxidative power to oxidize the fuel. Concerning hydrogen production, it was found that it is difficult to produce hydrogen in an alkaline environment even under bias, however, this is still possible if losses are minimized. One way to limit losses is to short-circuit anode and cathode electrode and put them close together. This is achieved in the "photoelectrocatalytic leaf", which was presently demonstrated capable of producing hydrogen even in a strongly alkaline environment.

  9. Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells.

    Science.gov (United States)

    Adachi, Kenjiro; Nikaido, Itoshi; Ohta, Hiroshi; Ohtsuka, Satoshi; Ura, Hiroki; Kadota, Mitsutaka; Wakayama, Teruhiko; Ueda, Hiroki R; Niwa, Hitoshi

    2013-11-07

    Sox2 is a transcription factor required for the maintenance of pluripotency. It also plays an essential role in different types of multipotent stem cells, raising the possibility that Sox2 governs the common stemness phenotype. Here we show that Sox2 is a critical downstream target of fibroblast growth factor (FGF) signaling, which mediates self-renewal of trophoblast stem cells (TSCs). Sustained expression of Sox2 together with Esrrb or Tfap2c can replace FGF dependency. By comparing genome-wide binding sites of Sox2 in embryonic stem cells (ESCs) and TSCs combined with inducible knockout systems, we found that, despite the common role in safeguarding the stem cell state, Sox2 regulates distinct sets of genes with unique functions in these two different yet developmentally related types of stem cells. Our findings provide insights into the functional versatility of transcription factors during embryogenesis, during which they can be recursively utilized in a variable manner within discrete network structures.

  10. The Economic Potential of Three Nuclear-Renewable Hybrid Energy Systems Providing Thermal Energy to Industry

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Mark [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cutler, Dylan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Flores-Espino, Francisco [National Renewable Energy Lab. (NREL), Golden, CO (United States); Stark, Greg [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jenkin, Thomas [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-12-01

    This report is one of a series of reports that Idaho National Laboratory and National Renewable Energy Laboratory are producing to investigate the technical and economic aspects of nuclear-renewable hybrid energy systems (N-R HESs). Previous reports provided results of an analysis of two N-R HES scenarios. This report builds that analysis with a Texas-synthetic gasoline scenario providing the basis in which the N-R HES sells heat directly to an industrial customer. Subsystems were included that convert electricity to heat thus allowing the renewable energy subsystem to generate heat and benefit from that revenue stream. Nuclear and renewable energy sources are important to consider in the energy sector's evolution because both are considered to be clean and non-carbon emitting energy sources.

  11. Renewability and emergy footprint at different spatial scales for innovative food systems in Europe

    DEFF Research Database (Denmark)

    Wright, Christina; Østergård, Hanne

    2016-01-01

    Food production is increasingly being challenged by limited resources of energy and land as well as bygrowing demand for food. In a future with less availability of fossil fuels, land area will become veryimportant for capturing the flow-limited renewable resources. Emergy assessment has been...... applied tocalculate scale dependent indicators, which account for the land area needed, if agricultural systems wereto be supported solely on renewable sources. These indicators are designated emergy footprints (EmFs)and expand the concept of support area defined previously in emergy accounting. The Em......F (in ha) iscalculated based on renewable empower densities which convert resource use into area equivalents ableto capture renewable flows. The spatial division between on-site, local and non-local land areas appliedin this study, identifies where the support area is located in order to apply a site...

  12. Hydrogen and renewable energy sources integrated system for greenhouse heating

    Directory of Open Access Journals (Sweden)

    Ileana Blanco

    2013-09-01

    Full Text Available A research is under development at the Department of Agro- Environmental Sciences of the University of Bari “Aldo Moro” in order to investigate the suitable solutions of a power system based on solar energy (photovoltaic and hydrogen, integrated with a geothermal heat pump for powering a self sustained heated greenhouse. The electrical energy for heat pump operation is provided by a purpose-built array of solar photovoltaic modules, which supplies also a water electrolyser system controlled by embedded pc; the generated dry hydrogen gas is conserved in suitable pressured storage tank. The hydrogen is used to produce electricity in a fuel cell in order to meet the above mentioned heat pump power demand when the photovoltaic system is inactive during winter night-time or the solar radiation level is insufficient to meet the electrical demand. The present work reports some theoretical and observed data about the electrolyzer operation. Indeed the electrolyzer has required particular attention because during the experimental tests it did not show a stable operation and it was registered a performance not properly consistent with the predicted performance by means of the theoretical study.

  13. SIMULATION OF THE SYSTEMS WITH RENEWABLE ENERGY SOURCES USING HOMER SOFTWARE

    Directory of Open Access Journals (Sweden)

    FIRINCĂ S.D.

    2015-06-01

    Full Text Available This paper simulates by using the Homer software, a distributed energy system with capacity below 1 MW. Among the renewable energy sources are used wind and solar energy. For photovoltaic panels, we are considering two situations: fixed panels, oriented at 45° and panels with tracking system with two axis. Simulation results contain information regarding operation hours of the system throughout the year, energy produced from the renewable energy sources, energy consumption for the load, and excess of electrical energy. The Homer software also allows an economic analysis of these systems.

  14. SIMULATION OF THE SYSTEMS WITH RENEWABLE ENERGY SOURCES USING HOMER SOFTWARE

    Directory of Open Access Journals (Sweden)

    FIRINCĂ S.D.

    2015-12-01

    Full Text Available This paper simulates by using the Homer software, distributed energy systems with capacity below 1 MW. Among the renewable energy sources are used wind and solar energy. For photovoltaic panels, we are considering two situations: fixed panels, oriented at 45 ° and panels with tracking system with two axis. Simulation results contain information regarding operation hours of the system throughout the year, energy produced from the renewable energy sources, energy consumption for the load, and excess of electrical energy. The Homer software also allows an economic analysis of these systems.

  15. Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop.

    Science.gov (United States)

    Tang, Kai-Dun; Liu, Ji; Jovanovic, Lidija; An, Jiyuan; Hill, Michelle M; Vela, Ian; Lee, Terence Kin-Wah; Ma, Stephanie; Nelson, Colleen; Russell, Pamela J; Clements, Judith A; Ling, Ming-Tat

    2016-01-26

    Obesity has long been linked with prostate cancer progression, although the underlying mechanism is still largely unknown. Here, we report that adipocytes promote the enrichment of prostate cancer stem cells (CSCs) through a vicious cycle of autocrine amplification. In the presence of adipocytes, prostate cancer cells actively secrete the peptide hormone cholecystokinin (CCK), which not only stimulates prostate CSC self-renewal, but also induces cathepsin B (CTSB) production of the adipocytes. In return, CTSB facilitates further CCK secretion by the cancer cells. More importantly, inactivation of CCK receptor not only suppresses CTSB secretion by the adipocytes, but also synergizes the inhibitory effect of CTSB inhibitor on adipocyte-promoted prostate CSC self-renewal. In summary, we have uncovered a novel mechanism underlying the mutual interplay between adipocytes and prostate CSCs, which may help explaining the role of adipocytes in prostate cancer progression and provide opportunities for effective intervention.

  16. Smart Energy Systems for coherent 100% renewable energy and transport solutions

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Conolly, David;

    2015-01-01

    this, the Smart Energy System must have a number of appropriate infrastructures for the different sectors of the energy system, which are smart electricity grids, smart thermal grids (district heating and cooling), smart gas grids and other fuel infrastructures. It enables fluctuating renewable energy...... (such as wind, solar, wave power and low value heat sources) to utilise new sources of flexibility such as solid, gaseous, and liquid fuel storage, thermal storage and heat pumps and battery electric vehicles. Smart Energy Systems also enable a more sustainable and feasible use of bioenergy than......The hypothesis of this paper is that in order to identify least cost solutions of the integration of fluctuating renewable energy sources into current or future 100% renewable energy supplies one has to take a Smart Energy Systems approach. This paper outline why and how to do so. Traditionally...

  17. Momentum is increasing towards a flexible electricity system based on renewables

    Science.gov (United States)

    Mitchell, Catherine

    2016-02-01

    Total global energy use is rising, and remains based on fossil fuels. Yet, the challenge of climate change requires a deep decarbonization of our energy system. Here I argue that the global energy policy discourse is moving rapidly towards one of renewable, energy-efficient and flexible electricity systems. This is primarily because of a rapid take-up within a few countries of variable renewable electricity sources over the past decade, resulting from falling renewable electricity prices, new and more economic means of flexible system operation, and changing social preferences. This in turn has led to widespread and supportive public policy announcements. I also argue that a ‘no-regrets’ energy policy is one that increases the energy system flexibility. Although the changing discourse is welcome, it is not to say that the challenge of climate change has been met. Policy statements must be backed up by more effective governance support and pressure to speed up change.

  18. Generic Energy Matching Model and Figure of Matching Algorithm for Combined Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    S. Y. Kan

    2009-08-01

    Full Text Available In this paper the Energy Matching Model and Figure of Matching Algorithm which originally was dedicated only to photovoltaic (PV systems [1] are extended towards a Model and Algorithm suitable for combined systems which are a result of integration of two or more renewable energy sources into one. The systems under investigation will range from mobile portable devices up to the large renewable energy system conceivably to be applied at the Afsluitdijk (Closure- dike in the north of the Netherlands. This Afsluitdijk is the major dam in the Netherlands, damming off the Zuiderzee, a salt water inlet of the North Sea and turning it into the fresh water lake of the IJsselmeer. The energy chain of power supplies based on a combination of renewable energy sources can be modeled by using one generic Energy Matching Model as starting point.

  19. Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions.

    Science.gov (United States)

    Lathia, J D; Hitomi, M; Gallagher, J; Gadani, S P; Adkins, J; Vasanji, A; Liu, L; Eyler, C E; Heddleston, J M; Wu, Q; Minhas, S; Soeda, A; Hoeppner, D J; Ravin, R; McKay, R D G; McLendon, R E; Corbeil, D; Chenn, A; Hjelmeland, A B; Park, D M; Rich, J N

    2011-09-01

    Malignant gliomas contain a population of self-renewing tumorigenic stem-like cells; however, it remains unclear how these glioma stem cells (GSCs) self-renew or generate cellular diversity at the single-cell level. Asymmetric cell division is a proposed mechanism to maintain cancer stem cells, yet the modes of cell division that GSCs utilize remain undetermined. Here, we used single-cell analyses to evaluate the cell division behavior of GSCs. Lineage-tracing analysis revealed that the majority of GSCs were generated through expansive symmetric cell division and not through asymmetric cell division. The majority of differentiated progeny was generated through symmetric pro-commitment divisions under expansion conditions and in the absence of growth factors, occurred mainly through asymmetric cell divisions. Mitotic pair analysis detected asymmetric CD133 segregation and not any other GSC marker in a fraction of mitoses, some of which were associated with Numb asymmetry. Under growth factor withdrawal conditions, the proportion of asymmetric CD133 divisions increased, congruent with the increase in asymmetric cell divisions observed in the lineage-tracing studies. Using single-cell-based observation, we provide definitive evidence that GSCs are capable of different modes of cell division and that the generation of cellular diversity occurs mainly through symmetric cell division, not through asymmetric cell division.

  20. The integration of renewable energies into the electricity systems of North Africa

    Energy Technology Data Exchange (ETDEWEB)

    Brand, Bernhard

    2015-11-01

    How can renewable energy sources be efficiently integrated into the North African electricity systems? By using techno-economic modeling methods, this book explores optimized electricity system expansion pathways until the year 2030 for the five North African countries - Morocco, Algeria, Tunisia, Libya and Egypt. The results indicate that renewable energy integration is actually a viable business case for the entire region, if wind and solar capacities are properly planned in conjunction with the conventional generation system and under consideration of the country-specific electricity supply-/demand patterns. Further aspects featured in this publication are the impact of renewable power on the transnational electricity transmission system and the question how decision making processes about renewable energy strategies can be improved in the North African context. The book is a contribution to the scientific literature about energy issues in the Middle East and North Africa (MENA), but also seeks to address political and industrial practitioners concerned with the development of the region's renewable energy future.

  1. Curtailment in a Highly Renewable Power System and Its Effect on Capacity Factors

    Directory of Open Access Journals (Sweden)

    Alexander Kies

    2016-06-01

    Full Text Available The capacity factor of a power plant is the ratio of generation over its potential generation. It is an important measure to describe wind and solar resources. However, the fluctuating nature of renewable power generation makes it difficult to integrate all generation at times. Whenever generation exceeds the load, curtailment or storage of energy is required. With increasing renewable shares in the power system, the level of curtailment will further increase. In this work, the influence of the curtailment on the capacity factors for a highly renewable German power system is studied. An effective capacity factor is introduced, and the implications for the distribution of renewable power plants are discussed. Three years of highly-resolved weather data were used to model wind and solar power generation. Together with historical load data and a transmission model, a possible future German power system was simulated. It is shown that effective capacity factors for unlimited transmission are strongly reduced by up to 60% (wind and 70% (photovoltaics and therefore of limited value in a highly renewable power system. Furthermore, the results demonstrate that wind power benefits more strongly from a reinforced transmission grid than photovoltaics (PV does.

  2. Self Renewal of Spermatogonial Stem Cells: the Most Promising Multipotent Cells - A Review

    OpenAIRE

    J. Tokas; C. S. Mukhopadhyay and Archana Verma

    2011-01-01

    Germ cells are endowed with unique properties like the ability to undergo meiosis and differentiate into gametes in order to perpetuate the genetic material. Spermatogonial stem cells (SSC) are considered as the best suited undifferentiated germ cells and are being consistently studied to reveal the basic physiology, genomics and transcriptomics of those cells. SSC provide an excellent model system to understand the differentiation, development and functioning of gonads and further use of the...

  3. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells.

    Science.gov (United States)

    Zeng, An; Li, Yong-Qin; Wang, Chen; Han, Xiao-Shuai; Li, Ge; Wang, Jian-Yong; Li, Dang-Sheng; Qin, Yong-Wen; Shi, Yufang; Brewer, Gary; Jing, Qing

    2013-04-29

    Adult stem cells (ASCs) capable of self-renewal and differentiation confer the potential of tissues to regenerate damaged parts. Epigenetic regulation is essential for driving cell fate decisions by rapidly and reversibly modulating gene expression programs. However, it remains unclear how epigenetic factors elicit ASC-driven regeneration. In this paper, we report that an RNA interference screen against 205 chromatin regulators identified 12 proteins essential for ASC function and regeneration in planarians. Surprisingly, the HP1-like protein SMED-HP1-1 (HP1-1) specifically marked self-renewing, pluripotent ASCs, and HP1-1 depletion abrogated self-renewal and promoted differentiation. Upon injury, HP1-1 expression increased and elicited increased ASC expression of Mcm5 through functional association with the FACT (facilitates chromatin transcription) complex, which consequently triggered proliferation of ASCs and initiated blastema formation. Our observations uncover an epigenetic network underlying ASC regulation in planarians and reveal that an HP1 protein is a key chromatin factor controlling stem cell function. These results provide important insights into how epigenetic mechanisms orchestrate stem cell responses during tissue regeneration.

  4. Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling.

    Science.gov (United States)

    Lim, Xinhong; Tan, Si Hui; Koh, Winston Lian Chye; Chau, Rosanna Man Wah; Yan, Kelley S; Kuo, Calvin J; van Amerongen, Renée; Klein, Allon Moshe; Nusse, Roel

    2013-12-06

    The skin is a classical example of a tissue maintained by stem cells. However, the identity of the stem cells that maintain the interfollicular epidermis and the source of the signals that control their activity remain unclear. Using mouse lineage tracing and quantitative clonal analyses, we showed that the Wnt target gene Axin2 marks interfollicular epidermal stem cells. These Axin2-expressing cells constitute the majority of the basal epidermal layer, compete neutrally, and require Wnt/β-catenin signaling to proliferate. The same cells contribute robustly to wound healing, with no requirement for a quiescent stem cell subpopulation. By means of double-labeling RNA in situ hybridization in mice, we showed that the Axin2-expressing cells themselves produce Wnt signals as well as long-range secreted Wnt inhibitors, suggesting an autocrine mechanism of stem cell self-renewal.

  5. Homeostatic Epithelial Renewal in the Gut Is Required for Dampening a Fatal Systemic Wound Response in Drosophila

    Directory of Open Access Journals (Sweden)

    Asuka Takeishi

    2013-03-01

    Full Text Available Effective defense responses involve the entire organism. To maintain body homeostasis after tissue damage, a systemic wound response is induced in which the response of each tissue is tightly orchestrated to avoid incomplete recovery or an excessive, damaging response. Here, we provide evidence that in the systemic response to wounding, an apoptotic caspase pathway is activated downstream of reactive oxygen species in the midgut enterocytes (ECs, cells distant from the wound site, in Drosophila. We show that a caspase-pathway mutant has defects in homeostatic gut cell renewal and that inhibiting caspase activity in fly ECs results in the production of systemic lethal factors after wounding. Our results indicate that wounding remotely controls caspase activity in ECs, which activates the tissue stem cell regeneration pathway in the gut to dampen the dangerous systemic wound reaction.

  6. Global Renewable Energy-Based Electricity Generation and Smart Grid System for Energy Security

    Directory of Open Access Journals (Sweden)

    M. A. Islam

    2014-01-01

    Full Text Available Energy is an indispensable factor for the economic growth and development of a country. Energy consumption is rapidly increasing worldwide. To fulfill this energy demand, alternative energy sources and efficient utilization are being explored. Various sources of renewable energy and their efficient utilization are comprehensively reviewed and presented in this paper. Also the trend in research and development for the technological advancement of energy utilization and smart grid system for future energy security is presented. Results show that renewable energy resources are becoming more prevalent as more electricity generation becomes necessary and could provide half of the total energy demands by 2050. To satisfy the future energy demand, the smart grid system can be used as an efficient system for energy security. The smart grid also delivers significant environmental benefits by conservation and renewable generation integration.

  7. Global renewable energy-based electricity generation and smart grid system for energy security.

    Science.gov (United States)

    Islam, M A; Hasanuzzaman, M; Rahim, N A; Nahar, A; Hosenuzzaman, M

    2014-01-01

    Energy is an indispensable factor for the economic growth and development of a country. Energy consumption is rapidly increasing worldwide. To fulfill this energy demand, alternative energy sources and efficient utilization are being explored. Various sources of renewable energy and their efficient utilization are comprehensively reviewed and presented in this paper. Also the trend in research and development for the technological advancement of energy utilization and smart grid system for future energy security is presented. Results show that renewable energy resources are becoming more prevalent as more electricity generation becomes necessary and could provide half of the total energy demands by 2050. To satisfy the future energy demand, the smart grid system can be used as an efficient system for energy security. The smart grid also delivers significant environmental benefits by conservation and renewable generation integration.

  8. A review of computer tools for analysing the integration of renewable energy into various energy systems

    DEFF Research Database (Denmark)

    Connolly, D.; Lund, Henrik; Mathiesen, Brian Vad;

    2010-01-01

    of contact. The results in this paper provide the information necessary to identify a suitable energy tool for analysing the integration of renewable energy into various energy-systems under different objectives. It is evident from this paper that there is no energy tool that addresses all issues related...... to integrating renewable energy, but instead the ‘ideal’ energy tool is highly dependent on the specific objectives that must be fulfilled. The typical applications for the 37 tools reviewed (from analysing single-building systems to national energy-systems), combined with numerous other factors......This paper includes a review of the different computer tools that can be used to analyse the integration of renewable energy. Initially 68 tools were considered, but 37 were included in the final analysis which was carried out in collaboration with the tool developers or recommended points...

  9. Integrating Renewable Energy into the Transmission and Distribution System of the U. S. Virgin Islands

    Energy Technology Data Exchange (ETDEWEB)

    Burman, K.; Olis, D.; Gevorgian, V.; Warren, A.; Butt, R.; Lilienthal, P.; Glassmire, J.

    2011-09-01

    This report focuses on the economic and technical feasibility of integrating renewable energy technologies into the U.S. Virgin Islands transmission and distribution systems. The report includes three main areas of analysis: 1) the economics of deploying utility-scale renewable energy technologies on St. Thomas/St. John and St. Croix; 2) potential sites for installing roof- and ground-mount PV systems and wind turbines and the impact renewable generation will have on the electrical subtransmission and distribution infrastructure, and 3) the feasibility of a 100- to 200-megawatt power interconnection of the Puerto Rico Electric Power Authority (PREPA), Virgin Islands Water and Power Authority (WAPA), and British Virgin Islands (BVI) grids via a submarine cable system.

  10. Development and commercialization of renewable energy technologies in Canada: An innovation system perspective

    Energy Technology Data Exchange (ETDEWEB)

    Jagoda, Kalinga; Lonseth, Robert; Lonseth, Adam [Bissett School of Business, Mount Royal University, 4825 Mount Royal Gate SW, Calgary AB T3E 6K6 (Canada); Jackman, Tom [Simple Solar Heating Limited, P.O. Box 988, Okotoks AB T1S 1B1 (Canada)

    2011-04-15

    The increased environmental awareness coupled with the recent changes in the oil prices triggered the necessity of focusing on effective management of energy systems. Global climate change has caused many people to consider ways of reducing greenhouse gases Renewable energy has become an essential feature in curtailing emission of Green House Gases, while meeting the demand for energy. This paper presents an innovation system framework for development and diffusion of renewable energy technologies. The framework is used to identify opportunities for small and medium enterprises in the renewable energy sector. A case study on a successful development, installation and implementation of solar thermal systems households in Calgary, Alberta, by an entrepreneurial firm, is also presented. (author)

  11. Photocatalytically Renewable Micro-electrochemical Sensor for Real-Time Monitoring of Cells.

    Science.gov (United States)

    Xu, Jia-Quan; Liu, Yan-Ling; Wang, Qian; Duo, Huan-Huan; Zhang, Xin-Wei; Li, Yu-Tao; Huang, Wei-Hua

    2015-11-23

    Electrode fouling and passivation is a substantial and inevitable limitation in electrochemical biosensing, and it is a great challenge to efficiently remove the contaminant without changing the surface structure and electrochemical performance. Herein, we propose a versatile and efficient strategy based on photocatalytic cleaning to construct renewable electrochemical sensors for cell analysis. This kind of sensor was fabricated by controllable assembly of reduced graphene oxide (RGO) and TiO2 to form a sandwiching RGO@TiO2 structure, followed by deposition of Au nanoparticles (NPs) onto the RGO shell. The Au NPs-RGO composite shell provides high electrochemical performance. Meanwhile, the encapsulated TiO2 ensures an excellent photocatalytic cleaning property. Application of this renewable microsensor for detection of nitric oxide (NO) release from cells demonstrates the great potential of this strategy in electrode regeneration and biosensing.

  12. Hair Follicle Melanocyte Cells as a Renewable Source of Melanocytes for Culture and Transplantation

    Directory of Open Access Journals (Sweden)

    Kwon, Ho

    2008-01-01

    Full Text Available Objective: Advances in melanocyte culture techniques have not yet led to reliable clinical methods for treating hypopigmentation disorders. We hypothesized that melanocytes harvested from plucked hair follicles may provide a renewable source of melanocytes for the treatment of hypopigmentation. Methods: Hairs with attached cells from the follicles were plucked from Yucatan pigs and implanted in a collagen-glycosaminoglycan matrix for either immediate or delayed implantation into full-thickness excisional porcine wounds. Wounds were allowed to heal and were biopsied at 2 and 4 weeks, respectively. Results: Fully healed wounds with transplanted hair follicles showed central areas of dark pigmentation corresponding to the location of implanted hair follicles. Corresponding collagen-glycosaminoglycan matrix wounds showed no central areas of pigmentation. Conclusions: Hair follicle--derived melanocytes may potentially serve as a renewable source of pigment-producing cells for treating hypopigmentation disorders.

  13. FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal

    Directory of Open Access Journals (Sweden)

    Suchitra D. Gopinath

    2014-04-01

    Full Text Available Skeletal muscle stem cells, or “satellite cells” (SCs, are required for the regeneration of damaged muscle tissue. Although SCs self-renew during regeneration, the mechanisms that govern SC re-entry into quiescence remain elusive. We show that FOXO3, a member of the forkhead family of transcription factors, is expressed in quiescent SCs (QSCs. Conditional deletion of Foxo3 in QSCs impairs self-renewal and increases the propensity of SCs to adopt a differentiated fate. Transcriptional analysis of SCs lacking FOXO3 revealed a downregulation of Notch signaling, a key regulator of SC quiescence. Conversely, overexpression of Notch intracellular domain (NICD rescued the self-renewal deficit of FOXO3-deficient SCs. We show that FOXO3 regulates NOTCH1 and NOTCH3 receptor expression and that decreasing expression of NOTCH1 and NOTCH3 receptors phenocopies the effect of FOXO3 deficiency in SCs. We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration.

  14. Sizing of Energy Storage Systems for Output Smoothing of Renewable Energy Systems

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Renewable energy sources (RESs), such as photovoltaic (PV) and wind power generation, have the characteristics of random fluctuation and intermittence. The output of RESs should be smoothed to inhibit the adverse effects of RESs fluctuations on the power grid. The energy storage system (ESS) is playing a more and more important role in the application of RESs due to its discharge/charge characteristic. Therefore, the optimal planning and design of ESS is of vital importance because of the expensive cost of ESS.

  15. Energy system analysis of 100% renewable energy systems-The case of Denmark in years 2030 and 2050

    DEFF Research Database (Denmark)

    Lund, Henrik; Mathiesen, Brian Vad

    2009-01-01

    for two energy target years: year 2050 with 100% renewable energy from biomass and combinations of wind, wave and solar power; and year 2030 with 50% renewable energy, emphasising the first important steps on the way. The conclusion is that a 100% renewable energy supply based on domestic resources......This paper presents the methodology and results of the overall energy system analysis of a 100% renewable energy system. The input for the systems is the result of a project of the Danish Association of Engineers, in which 1600 participants during more than 40 seminars discussed and designed...... is physically possible, and that the first step towards 2030 is feasible to Danish society. However, Denmark will have to consider to which degree the country shall rely mostly on biomass resources, which will involve the reorganisation of the present use of farming areas, or mostly on wind power, which...

  16. Small-Scale Renewable Energy Systems in the Development of Distributed Generation in Poland

    Directory of Open Access Journals (Sweden)

    Chodkowska-Miszczuk Justyna

    2014-07-01

    Full Text Available Small-scale renewable energy systems in the context of the development of distributed generation, are discussed for the case of Poland. A distributed energy system is efficient, reliable and environmentally friendly, and is one of the most recent trends in the development of the energy sector in Poland. One of the important dimensions of this process is the creation of micro- and small-power producers based on renewable, locally-available energy sources. It is clear that the development of small-scale renewable energy producers takes place in two ways. One of these is through small hydropower plants, which are the aftermath of hydropower development in areas traditionally associated with water use for energy purposes (northern and western Poland. The second is through other renewable energy sources, mainly biogas and solar energy and located primarily in southern Poland, in highly urbanized areas (e.g. Śląskie Voivodship. In conclusion, the development of small-scale renewable energy systems in Poland is regarded as a good option with respect to sustainable development.

  17. Renewable Energy Use in Smallholder Farming Systems: A Case Study in Tafresh Township of Iran

    Directory of Open Access Journals (Sweden)

    Hossein Shabanali Fami

    2010-03-01

    Full Text Available This study was conducted to investigate use of renewable energy and materials in smallholder farming system of the Tafresh township of Iran. The population of the study consisted of 2,400 small farmers working in the smallholder farming systems of the area, in which 133 people were selected as sample using Cochran formula and simple random sampling technique. In order to gather the information, a questionnaire was developed for the study and validated by the judgment of the experts in agricultural development and extension. The reliability of the main scales of the questionnaire was examined by Cronbach Alpha coefficients, which ranged from 0.7 to 0.93, indicating the tool of study is reliable. The findings revealed that the majority of the respondents use renewable energy and materials directly in its traditional forms without enabling technologies, and they lack the access to renewable technologies to improve the efficiency of energy use. They preferred fossil energy for many activities due to its lower cost and ease of access. The overall conclusion is that there are potentials and capacities for using renewable energies and materials in the farming systems of the Tafresh township. The government has to support and encourage the adoption of renewable technologies and abandon fossil fuels wherever possible.

  18. Nuclear-Renewable Hybrid System Economic Basis for Electricity, Fuel, and Hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Charles Forsberg; Steven Aumeier

    2014-04-01

    Concerns about climate change and altering the ocean chemistry are likely to limit the use of fossil fuels. That implies a transition to a low-carbon nuclear-renewable electricity grid. Historically variable electricity demand was met using fossil plants with low capital costs, high operating costs, and substantial greenhouse gas emissions. However, the most easily scalable very-low-emissions generating options, nuclear and non-dispatchable renewables (solar and wind), are capital-intensive technologies with low operating costs that should operate at full capacities to minimize costs. No combination of fully-utilized nuclear and renewables can meet the variable electricity demand. This implies large quantities of expensive excess generating capacity much of the time. In a free market this results in near-zero electricity prices at times of high nuclear renewables output and low electricity demand with electricity revenue collapse. Capital deployment efficiency—the economic benefit derived from energy systems capital investment at a societal level—strongly favors high utilization of these capital-intensive systems, especially if low-carbon nuclear renewables are to replace fossil fuels. Hybrid energy systems are one option for better utilization of these systems that consumes excess energy at times of low prices to make some useful product.The economic basis for development of hybrid energy systems is described for a low-carbon nuclear renewable world where much of the time there are massivequantities of excess energy available from the electric sector.Examples include (1) high-temperature electrolysis to generate hydrogen for non-fossil liquid fuels, direct use as a transport fuel, metal reduction, etc. and (2) biorefineries.Nuclear energy with its concentrated constant heat output may become the enabling technology for economically-viable low-carbon electricity grids because hybrid nuclear systems may provide an economic way to produce dispatachable variable

  19. Renewables in future power systems implications of technological learning and uncertainty

    CERN Document Server

    Wagner, Fabian

    2014-01-01

    The book examines the future deployment of renewable power from a normative point of view. It identifies properties characterizing the cost-optimal transition towards a renewable power system and analyzes the key drivers behind this transition. Among those drivers, particular attention is paid to technological cost reductions and the implications of uncertainty. From a methodological perspective, the main contributions of this book relate to the field of endogenous learning and uncertainty in optimizing energy system models. The primary objective here is closing the gap between the strand of l

  20. A 100% renewable power system for Europe - Let the weather and physics decide!

    DEFF Research Database (Denmark)

    Greiner, Martin; Heide, Dominik; Rasmussen, Morten Grud;

    The design of sustainable energy systems is no longer only the domain of politics, economics and engineering. Mathematical physics is able to contribute with its generic understanding of everything. A new modeling approach is presented and applied to design a fully renewable European power system....... This approach is based on weather data with good spatio-temporal resolution, which is first converted into wind and solar power generation and then used to derive estimates on the optimal mix between the renewable resources and the storage needs....

  1. Discovery of Power-Law Growth in the Self-Renewal of Heterogeneous Glioma Stem Cell Populations.

    Directory of Open Access Journals (Sweden)

    Michiya Sugimori

    Full Text Available Accumulating evidence indicates that cancer stem cells (CSCs drive tumorigenesis. This suggests that CSCs should make ideal therapeutic targets. However, because CSC populations in tumors appear heterogeneous, it remains unclear how CSCs might be effectively targeted. To investigate the mechanisms by which CSC populations maintain heterogeneity during self-renewal, we established a glioma sphere (GS forming model, to generate a population in which glioma stem cells (GSCs become enriched. We hypothesized, based on the clonal evolution concept, that with each passage in culture, heterogeneous clonal sublines of GSs are generated that progressively show increased proliferative ability.To test this hypothesis, we determined whether, with each passage, glioma neurosphere culture generated from four different glioma cell lines become progressively proliferative (i.e., enriched in large spheres. Rather than monitoring self-renewal, we measured heterogeneity based on neurosphere clone sizes (#cells/clone. Log-log plots of distributions of clone sizes yielded a good fit (r>0.90 to a straight line (log(% total clones = k*log(#cells/clone indicating that the system follows a power-law (y = xk with a specific degree exponent (k = -1.42. Repeated passaging of the total GS population showed that the same power-law was maintained over six passages (CV = -1.01 to -1.17. Surprisingly, passage of either isolated small or large subclones generated fully heterogeneous populations that retained the original power-law-dependent heterogeneity. The anti-GSC agent Temozolomide, which is well known as a standard therapy for glioblastoma multiforme (GBM, suppressed the self-renewal of clones, but it never disrupted the power-law behavior of a GS population.Although the data above did not support the stated hypothesis, they did strongly suggest a novel mechanism that underlies CSC heterogeneity. They indicate that power-law growth governs the self-renewal of heterogeneous

  2. Regional Energy Planning Tool for Renewable Integrated Low-Energy District Heating Systems

    DEFF Research Database (Denmark)

    Tol, Hakan; Dincer, Ibrahim; Svendsen, Svend

    2013-01-01

    with low-energy houses in focus with intensified energy efficiency measures. Employing low-temperature operation allows the ease to exploit not only any type of heat source but also low-grade sources, i.e., renewable and industrial waste heat, which would otherwise be lost. In this chapter, a regional......Low-energy district heating systems, operating at low temperature of 55 °C as supply and 25°C as return, can be the energy solution as being the prevailing heating infrastructure in urban areas, considering future energy schemesaiming at increased exploitation of renewable energy sources together...... energy planning tool is described considered with various energy conversion systems based on renewable energy sources to be supplied to an integrated energy infrastructure involving a low-energy district heating, a district cooling, and an electricity grid. The developed tool is performed for two case...

  3. Strategies towards a 100% renewable energy system for Denmark in the Future Climate Project

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad

    2009-01-01

    energy system by the year 2050 are presented. Two short term transition target years in the process towards this goal are analysed for 2015 and 2030. The analyses reveal that implementing energy savings, renewable energy and more efficient conversion technologies can have positive socioeconomic effects......, create employment and potentially lead to large earnings on exports. If externalities such as health effects etc. are included, even more benefits can be expected. 100 per cent renewable energy systems will be technically possible in the future, and may even be economically beneficial compared......Greenhouse gas mitigation strategies are generally considered costly with world leaders often engaging in debate concerning the costs of mitigation and the distribution of these costs between different countries. In this paper, the analyses and results of the design of a 100 per cent renewable...

  4. Power electronic converter systems for direct drive renewable energy applications

    DEFF Research Database (Denmark)

    Chen, Zhe

    2013-01-01

    This chapter presents power electronic conversion systems for wind and marine energy generation applications, in particular, direct drive generator energy conversion systems. Various topologies are presented and system design optimization and reliability are briefly discussed....

  5. Differential coupling of self-renewal signaling pathways in murine induced pluripotent stem cells.

    Directory of Open Access Journals (Sweden)

    Luca Orlando

    Full Text Available The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs, exhibiting properties similar to those of embryonic stem cells (ESCs, has attracted much attention, with many studies focused on improving efficiency of derivation and unraveling the mechanisms of reprogramming. Despite this widespread interest, our knowledge of the molecular signaling pathways that are active in iPSCs and that play a role in controlling their fate have not been studied in detail. To address this shortfall, we have characterized the influence of different signals on the behavior of a model mouse iPSC line. We demonstrate significant responses of this iPSC line to the presence of serum, which leads to profoundly enhanced proliferation and, depending on the medium used, a reduction in the capacity of the iPSCs to self-renew. Surprisingly, this iPSC line was less sensitive to withdrawal of LIF compared to ESCs, exemplified by maintenance of expression of a Nanog-GFP reporter and enhanced self-renewal in the absence of LIF. While inhibition of phosphoinositide-3 kinase (PI3K signaling decreased iPSC self-renewal, inhibition of Gsk-3 promoted it, even in the absence of LIF. High passages of this iPSC line displayed altered characteristics, including genetic instability and a reduced ability to self-renew. However, this second feature could be restored upon inhibition of Gsk-3. Collectively, our data suggest modulation of Gsk-3 activity plays a key role in the control of iPSC fate. We propose that more careful consideration should be given to characterization of the molecular pathways that control the fate of different iPSC lines, since perturbations from those observed in naïve pluripotent ESCs could render iPSCs and their derivatives susceptible to aberrant and potentially undesirable behaviors.

  6. Investigation of Energy and Environmental Potentials of a Renewable Trigeneration System in a Residential Application

    Directory of Open Access Journals (Sweden)

    Eun-Chul Kang

    2016-09-01

    Full Text Available Micro polygeneration utilizing renewable energy is a suitable approach to reduce energy consumption and carbon emission by offering high-efficiency performance, offsetting the need for centrally-generated grid electricity and avoiding transmission/distribution losses associated with it. This paper investigates the energy and environmental potential of a renewable trigeneration system in a residential application under Incheon (Korea and Ottawa (Canada weather conditions. The trigeneration system consists of a ground-to-air heat exchanger (GAHX, photovoltaic thermal (PVT panels and an air-to-water heat pump (AWHP. The study is performed by simulations in TRNSYS (Version 17.02 environment. The performance of the trigeneration system is compared to a reference conventional system that utilizes a boiler for space and domestic hot water heating and a chiller for space cooling. Simulation results showed substantial annual primary energy savings from the renewable trigeneration system in comparison to the reference system—45% for Incheon and 42% for Ottawa. The CO2eq emission reduction from the renewable trigeneration system is also significant, standing at 43% for Incheon and 82% for Ottawa. Furthermore, trigeneration systems’ capability to generate electricity and thermal energy at the point of use is considered as an attractive option for inclusion in the future smart energy network applications.

  7. Energy storage systems for renewable island systems. An enormous global market potential

    Energy Technology Data Exchange (ETDEWEB)

    Blechinger, Philipp [Reiner Lemoine Institut gGmbH, Berlin (Germany); Berlin Institute of Technology, Berlin (Germany). Dept. of Engineering; Howe, Enrico; Cader, Catherina; Plessmann, Guido; Hlusiak, Markus; Seguin, Robert; Breyer, Christian [Reiner Lemoine Institut gGmbH, Berlin (Germany)

    2012-07-01

    Mini-grids with high shares of renewable energies usually require energy storage systems based on technological and economic reasons. According to natural conditions battery storage is often the only applicable storage technology and thus hybrid mini-grids can be considered as very attractive niche market in substitution of diesel minigrids. Unfortunately these mini-grids are difficult to identify in terms of location and size. Thus within this study small islands are analyzed to determine the market potential for energy storage systems. The focus is on tropical islands as they seem to be the most favourable islands due to their natural conditions. After simulating one hybrid energy system of Bequia, St Vincent, as case study, similar islands are identified via GIS analysis. The overall market potential for battery storage on tropical islands between 1,000 and 10,000 inhabitants ranges between 1.2 and 2.4 billion USD.

  8. Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche

    Directory of Open Access Journals (Sweden)

    Heather A. Himburg

    2012-10-01

    Full Text Available The mechanisms through which the bone marrow (BM microenvironment regulates hematopoietic stem cell (HSC fate remain incompletely understood. We examined the role of the heparin-binding growth factor pleiotrophin (PTN in regulating HSC function in the niche. PTN−/− mice displayed significantly decreased BM HSC content and impaired hematopoietic regeneration following myelosuppression. Conversely, mice lacking protein tyrosine phosphatase receptor zeta, which is inactivated by PTN, displayed significantly increased BM HSC content. Transplant studies revealed that PTN action was not HSC autonomous, but rather was mediated by the BM microenvironment. Interestingly, PTN was differentially expressed and secreted by BM sinusoidal endothelial cells within the vascular niche. Furthermore, systemic administration of anti-PTN antibody in mice substantially impaired both the homing of hematopoietic progenitor cells to the niche and the retention of BM HSCs in the niche. PTN is a secreted component of the BM vascular niche that regulates HSC self-renewal and retention in vivo.

  9. Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells.

    Science.gov (United States)

    Alam, Maroof; Rajabi, Hasan; Ahmad, Rehan; Jin, Caining; Kufe, Donald

    2014-05-15

    The capacity of breast cancer cells to form mammospheres in non-adherent serum-free culture is used as a functional characteristic of the self-renewing stem-like cell population. The present studies demonstrate that silencing expression of the MUC1-C oncoprotein inhibits growth of luminal MCF-7 and HER2-overexpressing SKBR3 breast cancer cells as mammospheres. We also show that triple-negative MDA-MB-468 breast cancer cells are dependent on MUC1-C for growth as mammospheres and tumor xenografts. Similar results were obtained when MUC1-C function was inhibited by expression of a MUC1-C(CQCAQA) mutant. Moreover, treatment with the MUC1-C inhibitor GO-203, a cell penetrating peptide that binds to the MUC1-C cytoplasmic domain and blocks MUC1-C function, confirmed the importance of this target for self-renewal. The mechanistic basis for these findings is supported by the demonstration that MUC1-C activates NF-κB, occupies the IL-8 promoter with NF-κB, and induces IL-8 transcription. MUC1-C also induces NF-κB-dependent expression of the IL-8 receptor, CXCR1. In concert with these results, targeting MUC1-C with GO-203 suppresses IL-8/CXCR1 expression and disrupts the formation of established mammospheres. Our findings indicate that MUC1-C contributes to the self-renewal of breast cancer cells by activating the NF-κBIL-8/CXCR1 pathway and that targeting MUC1-C represents a potential approach for the treatment of this population.

  10. Renewable energy.

    Science.gov (United States)

    Destouni, Georgia; Frank, Harry

    2010-01-01

    The Energy Committee of the Royal Swedish Academy of Sciences has in a series of projects gathered information and knowledge on renewable energy from various sources, both within and outside the academic world. In this article, we synthesize and summarize some of the main points on renewable energy from the various Energy Committee projects and the Committee's Energy 2050 symposium, regarding energy from water and wind, bioenergy, and solar energy. We further summarize the Energy Committee's scenario estimates of future renewable energy contributions to the global energy system, and other presentations given at the Energy 2050 symposium. In general, international coordination and investment in energy research and development is crucial to enable future reliance on renewable energy sources with minimal fossil fuel use.

  11. Stem cell self-renewal versus differentiation: Tumor suppressor Mei-P26 and miRNAs control the balance

    Institute of Scientific and Technical Information of China (English)

    Run Shen; Ting Xie

    2008-01-01

    @@ Stem cells, which can self-renew and produce different cell types, have been shown to be regulated by extrinsic signals and intrinsic factors. Drosophila ovarian germline stem cells (GSCs), representing one of the well-studied stem cells, continuously proliferate and generate differentiated cystoblasts, which further develop into oocytes.

  12. Review of the Optimal Design on a Hybrid Renewable Energy System

    Directory of Open Access Journals (Sweden)

    Wu Yuan-Kang

    2016-01-01

    Full Text Available Hybrid renewable energy systems, combining various kinds of technologies, have shown relatively high capabilities to solve reliability problems and have reduced cost challenges. The use of hybrid electricity generation/storage technologies is reasonable to overcome related shortcomings. While the hybrid renewable energy system is attractive, its design, specifically the determination of the size of PV, wind, and diesel power generators and the size of energy storage system in each power station, is very challenging. Therefore, this paper will focus on the system planning and operation of hybrid generation systems, and several corresponding topics and papers by using intelligent computing methods will be reviewed. They include typical case studies, modeling and system simulation, control and management, reliability and economic studies, and optimal design on a reliable hybrid generation system.

  13. Energy and chemicals from the selective electrooxidation of renewable diols by organometallic fuel cells.

    Science.gov (United States)

    Bellini, Marco; Bevilacqua, Manuela; Filippi, Jonathan; Lavacchi, Alessandro; Marchionni, Andrea; Miller, Hamish A; Oberhauser, Werner; Vizza, Francesco; Annen, Samuel P; Grützmacher, H

    2014-09-01

    Organometallic fuel cells catalyze the selective electrooxidation of renewable diols, simultaneously providing high power densities and chemicals of industrial importance. It is shown that the unique organometallic complex [Rh(OTf)(trop2NH)(PPh3)] employed as molecular active site in an anode of an OMFC selectively oxidizes a number of renewable diols, such as ethylene glycol , 1,2-propanediol (1,2-P), 1,3-propanediol (1,3-P), and 1,4-butanediol (1,4-B) to their corresponding mono-carboxylates. The electrochemical performance of this molecular catalyst is discussed, with the aim to achieve cogeneration of electricity and valuable chemicals in a highly selective electrooxidation from diol precursors.

  14. Renewable Energy Certificate (REC) Tracking Systems: Costs & Verification Issues (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Heeter, J.

    2013-10-01

    This document provides information on REC tracking systems: how they are used in the voluntary REC market, a comparison of REC systems fees and information regarding how they treat environmental attributes.

  15. Expert Opinion Analysis on Renewable Hydrogen Storage Systems Potential in Europe

    Directory of Open Access Journals (Sweden)

    Davide Astiaso Garcia

    2016-11-01

    Full Text Available Among the several typologies of storage technologies, mainly on different physical principles (mechanical, electrical and chemical, hydrogen produced by power to gas (P2G from renewable energy sources complies with chemical storage principle and is based on the conversion of electrical energy into chemical energy by means of the electrolysis of water which does not produce any toxic or climate-relevant emission. This paper aims to pinpoint the potential uses of renewable hydrogen storage systems in Europe, analysing current and potential locations, regulatory framework, governments’ outlooks, economic issues, and available renewable energy amounts. The expert opinion survey, already used in many research articles on different topics including energy, has been selected as an effective method to produce realistic results. The obtained results highlight strategies and actions to optimize the storage of hydrogen produced by renewables to face varying electricity demand and generation-driven fluctuations reducing the negative effects of the increasing share of renewables in the energy mix of European Countries.

  16. Transmission Needs In A Fully Renewable Pan-European Electricity System

    DEFF Research Database (Denmark)

    Rodriguez, Rolando A.; Bruun Andresen, Gorm; Becker, Sarah;

    2012-01-01

    Based on high-resolution weather and electrical load data, the transmission needs for a fully renewable pan-European electricity system are determined. The ideal cross-border transmission capacities turn out to be a factor 10 larger than those of today. A reduction of cross-border transmission...... capacities lead to a non-linear increase of balancing needs. A good compromise turns out to be a capacity layout, which is a factor 5 larger than today’s one. On average each country will only be able to import / export 40% of its residual demand / renewable excess generation....

  17. Techno-Economic Optimization of a Sustainable Energy System for a 100% Renewables Smart House

    DEFF Research Database (Denmark)

    Craciun, Vasile Simion; Blarke, Morten; Trifa, Viorel

    2012-01-01

    , and hot tap water demand, balancing fluctuating wind power and both solar power and solar thermal supply utilizing advanced heat pump and both electro-chemical electricity storage, and hot and cold thermal storages. Our research is basically concerned with the question of how to design 100 % renewable...... for a sustainable energy system for a 100% renewables based Smart House (SH). We have devised and analysed an innovative high-efficiency approach to residential energy supply. The analysis involves detailed technical specifications and considerations for providing optimal supply of electricity, heating, cooling...... technical and economic challenges. One such challenge is the discontinuity, or intermittency, of generation, as most renewable energy resources depend on the climate, which is why their use requires complex design, planning and control optimization strategies. This paper presents a model and optimization...

  18. Overview of Power Generation Sector of Bangladesh and Proposed Grid Connected Hybrid Renewable Energy System

    Directory of Open Access Journals (Sweden)

    Md. Raju Ahmed

    2014-11-01

    Full Text Available Electricity is the most usable form of energy, and one of the most crucial strategic issues for the sustainable development of a country. The projection of demand of electricity is an integral part of the planning process. Severe power crisis compelled the government to enter into contractual agreements for high-cost temporary solution such as rental power and small IPPS, on an emergency basis, most of these are diesel or liquid-fuel based. Load shading is an acute problem for the country. The country is confronting a simultaneous shortage of electricity. However, the country has substantial amount of renewable energy resources. The overview of power generation section of Bangladesh is presented; the potentiality of renewable energy sources in Bangladesh is discussed. Finally, a grid connected hybrid renewable energy system is proposed to overcome the problem of power crisis using sustainable clean energy at rural area.

  19. Renewable Energy Assessment of Bureau of Reclamation Land and Facilities Using Geographic Information Systems

    Energy Technology Data Exchange (ETDEWEB)

    Heimiller, D.; Haase, S.; Melius, J.

    2013-05-01

    This report summarizes results of geographic information system screening for solar and wind potential at select Bureau of Reclamation lands in the western United States. The study included both utility-scale and facility-scale potential. This study supplements information in the report titled Renewable Energy Assessment for the Bureau of Reclamation: Final Report.

  20. Redesign Electricity Market for the Next Generation Power System of Renewable Energy and Distributed Storage Technologies

    DEFF Research Database (Denmark)

    Feng, Donghan; Xu, Zhao; Østergaard, Jacob

    2010-01-01

    This paper proposes a stochastic time-series based method to simulate the volatility of intermittent renewable generation and distributed storage devices along timeline. The proposed method can calculate the optimal timeline for different electricity markets and power systems. In practice...

  1. Evaluating the Validity of Classroom Observations in the Head Start Designation Renewal System

    Science.gov (United States)

    Mashburn, Andrew J.

    2017-01-01

    Classroom observations are increasingly common in education policies as a means to assess the quality of teachers and/or education programs for purposes of making high-stakes decisions. This article considers one policy, the Head Start Designation Renewal System (DRS), which involves classroom observations to assess the quality of Head Start…

  2. Why does renewable energy diffuse so slowly? A review of innovation system problems

    NARCIS (Netherlands)

    Negro, S.O.; Alkemade, F.; Hekkert, M.P.

    2012-01-01

    In this paper we present a literature review of studies that have analysed the troublesome trajectory of different renewable energy technologies (RETs) development and diffusion in different, mainly European countries. We present an overview of typical systemic problems in the development of innovat

  3. Swiss pumped hydro storage potential for Germany's electricity system under high penetration of intermittent renewable energy

    NARCIS (Netherlands)

    van Meerwijk, Aagje J. H.; Davila-Martinez, Alejandro; Laugs, Gideon A. H.

    2016-01-01

    In order to cut greenhouse-gas emissions and increase energy security, the European Commission stimulates the deployment of intermittent renewable energy sources (IRES) towards 2050. In an electricity system with high shares of IRES implemented in the network, energy balancing like storage is needed

  4. Keeping an eye on reliability: the organizational requirements of future renewable energy systems

    NARCIS (Netherlands)

    Scholten, D.J.

    2012-01-01

    The reliable operation of energy infrastructures is more than just a technical matter. It is also dependent upon the organizational structure that enables and constrains entities in their management of operations. Yet this lesson seems forgotten in our planning of future renewable energy systems. Th

  5. Balancing Self-Renewal against Genome Preservation in Stem Cells: How to Have the Cake and Eat It Too?

    Science.gov (United States)

    Tsai, Robert Y.L.

    2016-01-01

    Stem cells are endowed with the awesome power of self-renewal and multi-lineage differentiation that allows them to be major contributors to tissue homeostasis. Owing to their longevity and self-renewal capacity, they are also faced with a higher risk of genomic damage compared to differentiated cells. Damage on the genome, if not prevented or repaired properly, will threaten the survival of stem cells and culminate in organ failure, premature aging, or cancer formation. It is therefore of paramount importance that stem cells remain genomically stable throughout life. Given their unique biological and functional requirement, stem cells are thought to manage genotoxic stress somewhat differently from non-stem cells. The focus of this article is to review the current knowledge on how stem cells escape the barrage of oxidative and replicative DNA damage to stay in self-renewal. A clear statement on this subject should help us better understand tissue regeneration, aging, and cancer. PMID:26886024

  6. A technical and economic analysis of one potential pathway to a 100% renewable energy system

    DEFF Research Database (Denmark)

    Connolly, David; Mathiesen, Brian Vad

    2014-01-01

    requirements, 5) adding flexible electricity demands and electric vehicles, 6) producing synthetic methanol/DME for transport, and finally 7) using synthetic gas to replace the remaining fossil fuels. For each stage, the technical and economic performance of the energy system is calculated. The results...... indicate that a 100% renewable energy system can provide the same end-user energy demands as today’s energy system and at the same price. Electricity will be the backbone of the energy system, but the flexibility in today’s electricity sector will be transferred from the supply side of the demand side...... in the future. Similarly, due to changes in the type of spending required in a 100% renewable energy system, this scenario will result in the creation of 100,000 additional jobs in Ireland compared to an energy system like today’s. These results are significant since they indicate that the transition to a 100...

  7. Control system renewal for efficient operation in RIKEN 18 GHz electron cyclotron resonance ion source

    Energy Technology Data Exchange (ETDEWEB)

    Uchiyama, A., E-mail: a-uchi@riken.jp; Ozeki, K.; Higurashi, Y.; Kidera, M.; Komiyama, M.; Nakagawa, T. [RIKEN Nishina Center, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)

    2016-02-15

    A RIKEN 18 GHz electron cyclotron resonance ion source (18 GHz ECRIS) is used as an external ion source at the Radioactive Ion Beam Factory (RIBF) accelerator complex to produce an intense beam of medium-mass heavy ions (e.g., Ca and Ar). In most components that comprise the RIBF, the control systems (CSs) are integrated by the Experimental Physics and Industrial Control System (EPICS). On the other hand, a non-EPICS-based system has hardwired controllers, and it is used in the 18 GHz ECRIS CS as an independent system. In terms of efficient and effective operation, the 18 GHz ECRIS CS as well as the RIBF CS should be renewed using EPICS. Therefore, we constructed an 18 GHz ECRIS CS by using programmable logic controllers with embedded EPICS technology. In the renewed system, an operational log system was developed as a new feature, for supporting of the 18 GHz ECRIS operation.

  8. The injury of serotonin on intestinal epithelium cell renewal of weaned diarrhoea mice

    Directory of Open Access Journals (Sweden)

    Y. Dong

    2016-12-01

    Full Text Available Diarrhoea is a common cause of death in children and weaned animals. Recent research has found that serotonin (5-HT in the gastrointestinal tract plays an important role in regulating growth and the maintenance of mucosa, which protect against diarrhoea. To determine the influence of 5-HT on intestinal epithelium cell renewal under weaned stress diarrhoea, a weaned-stress diarrhoea mouse model was established with senna infusion (15 mL/Kg via intragastric administration and stress restraint (SR. Mice with an increase in 5-HT were induced by intraperitoneal injection with citalopram hydrobromide (CH, 10 mg/Kg. The results demonstrated that compared with the control animals, diarrhoea appeared in weaned stress mice and the 5-HT content in the small intestine was significantly increased (P<0.05. Further, the caspase-3 cells and cells undergoing apoptosis in the small intestine were significantly increased, but the VH (villus height, V/C (villus height /crypt depth, and PCNA-positive rate significantly decreased. Compared with the control animals, CH increased the intestinal 5-HT content, caspase-3 cells and cells undergoing apoptosis but decreased the VH and V/C. Compared with both control and weaned stress animals, weaned stress animals that were pre-treated with CH showed higher 5-HT concentrations, positive caspase-3 cells and cells undergoing apoptosis but lower VH, V/C and PCNA-positive rate. In vitro, a low concentration of 5-HT inhibit, IEC-6 cell line apoptosis but a higher concentration of 5-HT promoted it. Therefore, weaned stress diarrhoea mice were accompanied by a 5-HT increase in the small intestine and vice versa, and the increase in 5-HT induced by CH caused diarrhoea. In brief, 5-HT and diarrhoea slowed the intestinal epithelium cell renewal and injured the abortion function and mucosal barrier by decreasing VH, V/C and proliferation and increasing epithelium cell apoptosis.

  9. Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell

    Science.gov (United States)

    Gorba, Thorsten; Reitano, Erika; Toselli, Mauro; Biella, Gerardo; Sun, Yirui; Sanzone, Sveva; Ying, Qi-Long; Cattaneo, Elena

    2005-01-01

    Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions. Ex vivo expansion of pure populations of tissue stem cells has proven elusive. Neural progenitor cells are propagated in combination with differentiating progeny in floating clusters called neurospheres. The proportion of stem cells in neurospheres is low, however, and they cannot be directly observed or interrogated. Here we demonstrate that the complex neurosphere environment is dispensable for stem cell maintenance, and that the combination of fibroblast growth factor 2 (FGF-2) and epidermal growth factor (EGF) is sufficient for derivation and continuous expansion by symmetrical division of pure cultures of neural stem (NS) cells. NS cells were derived first from mouse ES cells. Neural lineage induction was followed by growth factor addition in basal culture media. In the presence of only EGF and FGF-2, resulting NS cells proliferate continuously, are diploid, and clonogenic. After prolonged expansion, they remain able to differentiate efficiently into neurons and astrocytes in vitro and upon transplantation into the adult brain. Colonies generated from single NS cells all produce neurons upon growth factor withdrawal. NS cells uniformly express morphological, cell biological, and molecular features of radial glia, developmental precursors of neurons and glia. Consistent with this profile, adherent NS cell lines can readily be established from foetal mouse brain. Similar NS cells can be generated from human ES cells and human foetal brain. The extrinsic factors EGF plus FGF-2 are sufficient to sustain pure symmetrical self-renewing divisions of NS cells. The resultant cultures constitute the first known example of tissue-specific stem cells that can be propagated without accompanying differentiation. These

  10. Niche-independent symmetrical self-renewal of a mammalian tissue stem cell.

    Directory of Open Access Journals (Sweden)

    Luciano Conti

    2005-09-01

    Full Text Available Pluripotent mouse embryonic stem (ES cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions. Ex vivo expansion of pure populations of tissue stem cells has proven elusive. Neural progenitor cells are propagated in combination with differentiating progeny in floating clusters called neurospheres. The proportion of stem cells in neurospheres is low, however, and they cannot be directly observed or interrogated. Here we demonstrate that the complex neurosphere environment is dispensable for stem cell maintenance, and that the combination of fibroblast growth factor 2 (FGF-2 and epidermal growth factor (EGF is sufficient for derivation and continuous expansion by symmetrical division of pure cultures of neural stem (NS cells. NS cells were derived first from mouse ES cells. Neural lineage induction was followed by growth factor addition in basal culture media. In the presence of only EGF and FGF-2, resulting NS cells proliferate continuously, are diploid, and clonogenic. After prolonged expansion, they remain able to differentiate efficiently into neurons and astrocytes in vitro and upon transplantation into the adult brain. Colonies generated from single NS cells all produce neurons upon growth factor withdrawal. NS cells uniformly express morphological, cell biological, and molecular features of radial glia, developmental precursors of neurons and glia. Consistent with this profile, adherent NS cell lines can readily be established from foetal mouse brain. Similar NS cells can be generated from human ES cells and human foetal brain. The extrinsic factors EGF plus FGF-2 are sufficient to sustain pure symmetrical self-renewing divisions of NS cells. The resultant cultures constitute the first known example of tissue-specific stem cells that can be propagated without accompanying

  11. Enterprise System Renewal : The Divergence between Perception and Reality

    NARCIS (Netherlands)

    Haake, Phillip; Schacht, Silvia; Mueller, Benjamin; Maedche, Alexander

    2017-01-01

    E-commerce based companies critically rely on the effective use of the information system used to support their processes. Accordingly, managers place a great emphasis on the success of projects to introduce such systems. However, research increasingly suggests that project success may not be as obj

  12. Nuclear-Renewable Hybrid Energy Systems: 2016 Technology Development Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    Bragg-Sitton, Shannon M. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Boardman, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Suk Kim, Jong [Idaho National Lab. (INL), Idaho Falls, ID (United States); McKellar, Michael [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sabharwall, Piyush [Idaho National Lab. (INL), Idaho Falls, ID (United States); Chen, Jun [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cetiner, M. Sacit [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Harrison, T. Jay [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Qualls, A. Lou [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-03-01

    The United States is in the midst of an energy revolution, spurred by advancement of technology to produce unprecedented supplies of oil and natural gas. Simultaneously, there is an increasing concern for climate change attributed to greenhouse gas (GHG) emissions that, in large part, result from burning fossil fuels. An international consensus has concluded that the U.S. and other developed nations have an imperative to reduce GHG emissions to address these climate change concerns. The global desire to reduce GHG emissions has led to the development and deployment of clean energy resources and technologies, particularly renewable energy technologies, at a rapid rate. At the same time, each of the major energy sectors—the electric grid, industrial manufacturing, transportation, and the residential/commercial consumers— is increasingly becoming linked through information and communications technologies, advanced modeling and simulation, and controls. Coordination of clean energy generation technologies through integrated hybrid energy systems, as defined below, has the potential to further revolutionize energy services at the system level by coordinating the exchange of energy currency among the energy sectors in a manner that optimizes financial efficiency (including capital investments), maximizes thermodynamic efficiency (through best use of exergy, which is the potential to use the available energy in producing energy services), reduces environmental impacts when clean energy inputs are maximized, and provides resources for grid management. Rapid buildout of renewable technologies has been largely driven by local, state, and federal policies, such as renewable portfolio standards and production tax credits that incentivize investment in these generation sources. A foundational assumption within this program plan is that renewable technologies will continue to be major contributors to the future U.S. energy infrastructure. While increased use of clean

  13. A technical and economic analysis of one potential pathway to a 100% renewable energy system

    Directory of Open Access Journals (Sweden)

    David Connolly

    2014-02-01

    Full Text Available This paper outlines how an existing energy system can be transformed into a 100% renewable energy system. The transition is divided into a number of key stages which reflect key radical technological changes on the supply side of the energy system. Ireland is used as a case study,but in reality this reflects many typical energy systems today which use power plants for electricity, individual boilers for heat, and oil for transport. The seven stages analysed are 1 reference, 2 introduction of district heating, 3 installation of small and large-scale heat pumps,4 reducing grid regulation requirements, 5 adding flexible electricity demands and electric vehicles, 6 producing synthetic methanol/DME for transport, and finally 7 using synthetic gas to replace the remaining fossil fuels. For each stage, the technical and economic performance of the energy system is calculated. The results indicate that a 100% renewable energy system can provide the same end-user energy demands as today’s energy system and at the same price. Electricity will be the backbone of the energy system, but the flexibility in today’s electricity sector will be transferred from the supply side of the demand side in the future. Similarly, due to changes in the type of spending required in a 100% renewable energy system, this scenario will result in the creation of 100,000 additional jobs in Ireland compared to an energy system like today’s. These results are significant since they indicate that the transition to a 100% renewable energy system can begin today, without increasing the cost of energy in the short- or long-term, if the costs currently forecasted for 2050 become a reality.

  14. Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells.

    Science.gov (United States)

    Sastry, K S R; Al-Muftah, M A; Li, Pu; Al-Kowari, M K; Wang, E; Ismail Chouchane, A; Kizhakayil, D; Kulik, G; Marincola, F M; Haoudi, A; Chouchane, L

    2014-12-01

    Emerging evidence suggests that the resistance of cancer stem cells (CSC) to many conventional therapies is one of the major limiting factors of cancer therapy efficacy. Identification of mechanisms responsible for survival and self-renewal of CSC will help design new therapeutic strategies that target and eliminate both differentiated cancer cells and CSC. Here we demonstrated the potential role of proapoptotic protein BAD in the biology of CSC in melanoma, prostate and breast cancers. We enriched CD44(+)/CD24(-) cells (CSC) by tumorosphere formation and purified this population by FACS. Both spheres and CSC exhibited increased potential for proliferation, migration, invasion, sphere formation, anchorage-independent growth, as well as upregulation of several stem cell-associated markers. We showed that the phosphorylation of BAD is essential for the survival of CSC. Conversely, ectopic expression of a phosphorylation-deficient mutant BAD induced apoptosis in CSC. This effect was enhanced by treatment with a BH3-mimetic, ABT-737. Both pharmacological agents that inhibit survival kinases and growth factors that are involved in drug resistance delivered their respective cytotoxic and protective effects by modulating the BAD phosphorylation in CSC. Furthermore, the frequency and self-renewal capacity of CSC was significantly reduced by knocking down the BAD expression. Consistent with our in vitro results, significant phosphorylation of BAD was found in CD44(+) CSC of 83% breast tumor specimens. In addition, we also identified a positive correlation between BAD expression and disease stage in prostate cancer, suggesting a role of BAD in tumor advancement. Our studies unveil the role of BAD in the survival and self-renewal of CSC and propose BAD not only as an attractive target for cancer therapy but also as a marker of tumor progression.

  15. Effect of Hypoxia on the Differentiation and the Self-Renewal of Metanephrogenic Mesenchymal Stem Cells

    Science.gov (United States)

    Liu, Shaopeng; Song, Nana; He, Jianqiang; Yu, Xiaofang; Guo, Jia; Jiao, Xiaoyan

    2017-01-01

    Hypoxia is an important and influential factor in development. The embryonic kidney is exposed to a hypoxic environment throughout its development. The Wnt/β-catenin pathway plays vital roles in the differentiation and self-renewal of metanephrogenic mesenchymal stem cells (MMSCs) from which the kidney is derived. Thus, we hypothesized that hypoxia can regulate the differentiation and pluripotency of MMSCs through the Wnt/β-catenin pathway. To test this hypothesis, MMSCs from rats at embryonic day 18.5 were cultured in normoxic (21% O2) and hypoxic (1% O2) conditions. The effects of hypoxia on differentiation, stemness, proliferation, and apoptosis of cultured MMSCs and on the activity of the Wnt/β-catenin pathway were tested. Our results revealed that the hypoxic condition increased the number of epithelial cells (E-cadherin+ or CK18+) as well the expression of markers of renal tubule epithelia cells (CDH6, Aqp1, and OPN), decreased the number and proliferation of stem cells (SIX-2+ or CITED1+), and induced apoptosis. Additionally, hypoxia reduced the expression of Wnt4 as well as its downstream molecules β-catenin, LEF-1, and Axin2. Activation of the Wnt/β-catenin pathway by LiCl or BIO modified the effects of hypoxia on the differentiation and self-renewal of MMSCs. Thus, we concluded that hypoxia induces the differentiation and inhibits the self-renewal of MMSCs by inhibiting the Wnt/β-catenin pathway. The observations further our understanding of the effects of hypoxia on kidney. PMID:28194187

  16. An Approach to Develop Embedded System For Web Based Monitoring & Controlling of Renewable Energy Sources

    Directory of Open Access Journals (Sweden)

    Akansha S. Fating

    2013-06-01

    Full Text Available The widespread application of Renewable Energy Sources (RESrequires centralized monitoring and controlling System. To makethese operations control room independent, there is need todevelop smart servers and web based applications. Cost is anessential factor of any embedded system design. This paperdiscusses a novel concept of designing of cost effective server/client embedded system Renewable Energy sources. Hereembedded server is developed with ARM9 controller loaded withwindows CE operating system. Low cost client are designedusing Atmega32 microcontroller with LAN connection. Server/client are connected in LAN system and server basedapplications has been developed to monitor/ controlling the clientoperation. The server has web based applications that can beaccessed via internet. Author has presented developed systemand results.

  17. Empowering Variable Renewables - Options for Flexible Electricity Systems

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, Hugo [Renewable Energy Unit, International Energy Agency, Paris (France)

    2008-07-01

    A flexible electricity system is one that can respond reliably, and rapidly, to large fluctuations in supply and demand. Flexibility is already present in all power systems, in order to manage fluctuations in demand, and it is crucial for high performance and economic and reliable operation. This paper looks at measures to increase flexibility. but careful cost/benefit analysis is essential, and specific national and regional circumstances will influence the choice of option(s).

  18. Adult stem cells and mammalian epimorphic regeneration-insights from studying annual renewal of deer antlers.

    Science.gov (United States)

    Li, Chunyi; Yang, Fuhe; Sheppard, Allan

    2009-09-01

    Mammalian organ regeneration is the "Holy Grail" of modern regenerative biology and medicine. The most dramatic organ replacement is known as epimorphic regeneration. To date our knowledge of epimorphic regeneration has come from studies of amphibians. Notably, these animals have the ability to reprogram phenotypically committed cells at the amputation plane toward an embryonic-like cell phenotype (dedifferentiation). The capability of mammals to initiate analogous regeneration, and whether similar mechanisms would be involved if it were to occur, remain unclear. Deer antlers are the only mammalian appendages capable of full renewal, and therefore offer a unique opportunity to explore how nature has solved the problem of mammalian epimorphic regeneration. Following casting of old hard antlers, new antlers regenerate from permanent bony protuberances, known as pedicles. Studies through morphological and histological examinations, tissue deletion and transplantation, and cellular and molecular techniques have demonstrated that antler renewal is markedly different from that of amphibian limb regeneration (dedifferentiation-based), being a stem cell-based epimorphic process. Antler stem cells reside in the pedicle periosteum. We envisage that epimorphic regeneration of mammalian appendages, other than antler, could be made possible by recreating comparable milieu to that which supports the elaboration of that structure from the pedicle periosteum.

  19. Adult hematopoietic stem cells lacking Hif-1α self-renew normally.

    Science.gov (United States)

    Vukovic, Milica; Sepulveda, Catarina; Subramani, Chithra; Guitart, Amélie V; Mohr, Jasmine; Allen, Lewis; Panagopoulou, Theano I; Paris, Jasmin; Lawson, Hannah; Villacreces, Arnaud; Armesilla-Diaz, Alejandro; Gezer, Deniz; Holyoake, Tessa L; Ratcliffe, Peter J; Kranc, Kamil R

    2016-06-09

    The hematopoietic stem cell (HSC) pool is maintained under hypoxic conditions within the bone marrow microenvironment. Cellular responses to hypoxia are largely mediated by the hypoxia-inducible factors, Hif-1 and Hif-2. The oxygen-regulated α subunits of Hif-1 and Hif-2 (namely, Hif-1α and Hif-2α) form dimers with their stably expressed β subunits and control the transcription of downstream hypoxia-responsive genes to facilitate adaptation to low oxygen tension. An initial study concluded that Hif-1α is essential for HSC maintenance, whereby Hif-1α-deficient HSCs lost their ability to self-renew in serial transplantation assays. In another study, we demonstrated that Hif-2α is dispensable for cell-autonomous HSC maintenance, both under steady-state conditions and following transplantation. Given these unexpected findings, we set out to revisit the role of Hif-1α in cell-autonomous HSC functions. Here we demonstrate that inducible acute deletion of Hif-1α has no impact on HSC survival. Notably, unstressed HSCs lacking Hif-1α efficiently self-renew and sustain long-term multilineage hematopoiesis upon serial transplantation. Finally, Hif-1α-deficient HSCs recover normally after hematopoietic injury induced by serial administration of 5-fluorouracil. We therefore conclude that despite the hypoxic nature of the bone marrow microenvironment, Hif-1α is dispensable for cell-autonomous HSC maintenance.

  20. Renewing the Future: Social Innovation Systems, Sector Shift, and Innoweave

    Directory of Open Access Journals (Sweden)

    Stephen Huddart

    2012-07-01

    Full Text Available Against a backdrop of various “occupy” movements signifying civic dissatisfaction with the social contract, and in an era of fiscal restraint affecting governments and communities in many parts of the world, we need new and more effective ways to address complex social challenges. While continuous innovation is commonly understood to be a source of growth, productivity improvement, and competitive advantage in the technology and manufacturing sectors, the author’s focus is on social innovation systems, designed to replace maladaptive institutions and obsolete policy frameworks with novel and disruptive means for improving outcomes on issues such as population health and climate change. This article proposes a definition of such systems, and examines how system-level tools including impact investing, open data platforms, and “change labs” are fostering collaboration among the private, public, and community sectors. We argue that a key priority at this time is to make these and other tools and processes for social innovation available to community organizations and their government and business partners everywhere, in a manner that allows for continuous cycles of implementation and learning. The author describes one such project currently being developed in Canada by Social Innovation Generation and other partners, called Innoweave. Innoweave is a technology-enabled social innovation system for sharing the tools and processes of social innovation with the community sector. The article concludes with a call for multi-sectoral participation in social innovation systems as an investment in society’s adaptive capacity and future wellbeing.

  1. Stochastic Modeling and Analysis of Power System with Renewable Generation

    DEFF Research Database (Denmark)

    Chen, Peiyuan

    of a substation transformer is determined by the sum of the maximum loading at individual radial feeders while assuming no generation output from local generators. However, such a deterministic analysis does not provide a realistic evaluation of system steady-state performance. A more realistic evaluation can...... that minimizes the expectation of power losses of a 69-bus distribution system by controlling the power factor of WTs. The optimization is subjected to the probabilistic constraints of bus voltage and line current. The algorithm combines a constrained nonlinear optimization algorithm and a Monte Carlo based PLF...

  2. Performance Analyses of Renewable and Fuel Power Supply Systems for Different Base Station Sites

    Directory of Open Access Journals (Sweden)

    Josip Lorincz

    2014-11-01

    Full Text Available Base station sites (BSSs powered with renewable energy sources have gained the attention of cellular operators during the last few years. This is because such “green” BSSs impose significant reductions in the operational expenditures (OPEX of telecom operators due to the possibility of on-site renewable energy harvesting. In this paper, the green BSSs power supply system parameters detected through remote and centralized real time sensing are presented. An implemented sensing system based on a wireless sensor network enables reliable collection and post-processing analyses of many parameters, such as: total charging/discharging current of power supply system, battery voltage and temperature, wind speed, etc. As an example, yearly sensing results for three different BSS configurations powered by solar and/or wind energy are discussed in terms of renewable energy supply (RES system performance. In the case of powering those BSS with standalone systems based on a fuel generator, the fuel consumption models expressing interdependence among the generator load and fuel consumption are proposed. This has allowed energy-efficiency comparison of the fuel powered and RES systems, which is presented in terms of the OPEX and carbon dioxide (CO2 reductions. Additionally, approaches based on different BSS air-conditioning systems and the on/off regulation of a daily fuel generator activity are proposed and validated in terms of energy and capital expenditure (CAPEX savings.

  3. Pretreated Landfill Gas Conversion Process via a Catalytic Membrane Reactor for Renewable Combined Fuel Cell-Power Generation

    Directory of Open Access Journals (Sweden)

    Zoe Ziaka

    2013-01-01

    Full Text Available A new landfill gas-based reforming catalytic processing system for the conversion of gaseous hydrocarbons, such as incoming methane to hydrogen and carbon oxide mixtures, is described and analyzed. The exit synthesis gas (syn-gas is fed to power effectively high-temperature fuel cells such as SOFC types for combined efficient electricity generation. The current research work is also referred on the description and design aspects of permreactors (permeable reformers carrying the same type of landfill gas-reforming reactions. Membrane reactors is a new technology that can be applied efficiently in such systems. Membrane reactors seem to perform better than the nonmembrane traditional reactors. The aim of this research includes turnkey system and process development for the landfill-based power generation and fuel cell industries. Also, a discussion of the efficient utilization of landfill and waste type resources for combined green-type/renewable power generation with increased processing capacity and efficiency via fuel cell systems is taking place. Moreover, pollution reduction is an additional design consideration in the current catalytic processors fuel cell cycles.

  4. RESRO: A spatio-temporal model to optimise regional energy systems emphasising renewable energies

    OpenAIRE

    2012-01-01

    RESRO (Reference Energy System Regional Optimization) optimises the simultaneous fulfilment of the heat and power demand in regional energy systems. It is a mixed-integer program realised in the modelling language GAMS. The model handles information on geographically disaggregated data describing heat demand and renewable energy potentials (e.g. biomass, solar energy, ambient heat). Power demand is handled spatially aggregated in an hourly time resolution within 8 type days. The major idea is...

  5. Renewable Energy, Photovoltaic Systems Near Airfields: Electromagnetic Interference

    Science.gov (United States)

    2015-04-01

    in the literature— electromagnetic interference (EMI). Typically, this phrase is taken to mean radio frequency (RF) emissions , emanating from PV... EMISSION LEVELS The Federal Communications Commission (FCC) CFR Title 47, Part 15 regulates RF emissions from commercial products. Compliance with Part...class ‘A’ emission at 30 MHz. Other pieces of PV systems equipment, such as step-up transformers, are not a source of EMI because of their low frequency

  6. Industrial Scale Energy Systems Integration; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Mark

    2015-07-28

    The industrial sector consumes 25% of the total energy in the U.S. and produces 18% of the greenhouse gas (GHG) emissions. Energy Systems Integration (ESI) opportunities can reduce those values and increase the profitability of that sector. This presentation outlines several options. Combined heat and power (CHP) is an option that is available today for many applications. In some cases, it can be extended to trigeneration by adding absorbtion cooling. Demand response is another option in use by the industrial sector - in 2012, industry provided 47% of demand response capacity. A longer term option that combines the benefits of CHP with those of demand response is hybrid energy systems (HESs). Two possible HESs are described and development implications discussed. extended to trigeneration by adding absorbtion cooling. Demand response is another option in use by the industrial sector - in 2012, industry provided 47% of demand response capacity. A longer term option that combines the benefits of CHP with those of demand response is hybrid energy systems (HESs). Two possible HESs are described and development implications discussed.

  7. Qualitative modeling identifies IL-11 as a novel regulator in maintaining self-renewal in human pluripotent stem cells

    Directory of Open Access Journals (Sweden)

    Hedi ePeterson

    2013-10-01

    Full Text Available Pluripotency in human embryonic stem cells (hESCs and induced pluripotent stem cells (iPSCs is regulated by three transcription factors - OCT3/4, SOX2 and NANOG. To fully exploit the therapeutic potential of these cells it is essential to have a good mechanistic understanding of the maintenance of self-renewal and pluripotency. In this study, we demonstrate a powerful systems biology approach in which we first expand literature-based network encompassing the core regulators of pluripotency by assessing the behaviour of genes targeted by perturbation experiments. We focused our attention on highly regulated genes encoding cell surface and secreted proteins as these can be more easily manipulated by the use of inhibitors or recombinant proteins. Qualitative modeling based on combining boolean networks and in silico perturbation experiments were employed to identify novel pluripotency-regulating genes. We validated Interleukin-11 (IL-11 and demonstrate that this cytokine is a novel pluripotency-associated factor capable of supporting self-renewal in the absence of exogenously added bFGF in culture. To date, the various protocols for hESCs maintenance require supplementation with bFGF to activate the Activin/Nodal branch of the TGFβ signaling pathway. Additional evidence supporting our findings is that IL-11 belongs to the same protein family as LIF, which is known to be necessary for maintaining pluripotency in mouse but not in human ESCs. These cytokines operate through the same gp130 receptor which interacts with Janus kinases. Our finding might explain why mESCs are in a more naïve cell state compared to hESCs and how to convert primed hESCs back to the naïve state. Taken together, our integrative modeling approach has identified novel genes as putative candidates to be incorporated into the expansion of the current gene regulatory network responsible for inducing and maintaining pluripotency.

  8. Advancing System Flexibility for High Penetration Renewable Integration

    Energy Technology Data Exchange (ETDEWEB)

    Milligan, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Frew, Bethany [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhou, Ella [National Renewable Energy Lab. (NREL), Golden, CO (United States); Arent, Douglas J. [Joint Inst. for Strategic Energy Analysis, Golden, CO (United States)

    2015-10-01

    This report summarizes some of the issues discussed during the engagement on power system flexibility. By design, the focus is on flexibility options used in the United States. Exploration of whether and how U.S. experiences can inform Chinese energy planning will be part of the continuing project, and will benefit from the knowledge base provided by this report. We believe the initial stage of collaboration represented in this report has successfully started a process of mutual understanding, helping Chinese researchers to begin evaluating how lessons learned in other countries might translate to China's unique geographic, economic, social, and political contexts.

  9. Towards fully renewable energy systems - Experience and trends in Denmark

    DEFF Research Database (Denmark)

    Pinson, Pierre; Mitridati, Lesia Marie-Jeanne Mariane; Ordoudis, Christos;

    2016-01-01

    the way operational practice has evolved, also shifting towards a liberalized electricity market environment, and more generally going along with other technological and societal evolution. Our aim here is to give an overview of recent and current initiatives in Denmark which contribute towards a goal.......g., wind and solar. Denmark is a country that invested early in wind energy, rapidly proposing very ambitious goals for the future of its energy system and global energy usage. While the case of Denmark is specific due to its limited size and good interconnections, there may still be a lot to learn from...

  10. Seasonal shifting of surplus renewable energy in a power system located in a cold region

    Directory of Open Access Journals (Sweden)

    Jorge Morel

    2014-10-01

    Full Text Available The Fukushima nuclear disaster in 2011 changed Japan's strategy for reducing CO2 emissions. The government is now placing more emphasis on the development of nonCO2-emitting distributed generation systems such as wind, solar, and tidal power to reduce greenhouse gas emissions and guarantee electricity supply in the case of a natural disaster. This paper proposes a strategy for the exploitation of wind, solar, and tidal resources in a cold region in Japan by utilizing surplus energy from the summer and spring during winter. It also aims to determine the most favorable energy mix of these renewable sources and storage system types. The study is performed by calculating hourly demand and renewable energy supply for the city in one year, which is based on actual data of demand, solar irradiation, wind speeds, and tidal current speeds. The costs of the components of the renewable power plants and storage systems are considered, and different proportions of generation outputs are evaluated with different types of storage systems. According to results, the configuration containing the hydrogen storage system using organic chemical hydride methylcyclohexane (OCHM is the most economical but is still more expensive than one using a conventional generation system. Moreover, we confirm that the cost of CO2 emissions is the key element for leveling the playing field between conventional and renewable generation from an economic perspective. The cost of CO2 emissions to public health as well as those costs related to the interruption of services during a catastrophe must be carefully calculated with other issues from conventional power projects to perform a precise comparative evaluation between both types of generation systems.

  11. Power Electronics – The Key Technology for Renewable Energy System Integration

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Yang, Yongheng; Ma, Ke

    2015-01-01

    and effectively, energy conversion systems, currently based on power electronics technology, will again play an essential role in this energy paradigm shift. Using highly efficient power electronics in power generation, power transmission/distribution and end-user application, together with advanced control...... solutions makes the way for renewable energies. In light of this, some of the most emerging renewable energies, e.g. wind energy and photovoltaic, which by means of power electronics are changing character as a major part in the electricity generation, are explored in this presentation. Issues like...... technology development, implementation, power converter technologies, control of the systems, and synchronization are addressed. Special focuses are paid on the future trends in power electronics for those systems like how to lower the cost of energy and to develop emerging power devices and better...

  12. Operating conditions of batteries in off-grid renewable energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Svoboda, Vojtech [University of Hawaii, 1680 East-West Rd., Post 109, Honolulu, HI 96822, (United States); Wenzl, Heinz [Beratung fuer Batterien und Energietechnik, Am Bergwaeldchen 27, 37520 Osterode (Germany); Kaiser, Rudi [Fraunhofer Institute for Solar Energy Systems, Heidenhofstrasse 2, 79110 Freiburg (Germany); Jossen, Andreas [Center for Solar Energy and Hydrogen Research Baden - Wuerttemberg, Helmholtzstrasse 8, 89081 Ulm (Germany); Baring-Gould, Ian [National Renewable Energy Laboratory, MS 3811, 1617 Cole Blvd, 80401-3393 Golden/CO (United States); Manwell, James [University of Massachusetts, Amherst, Massachusetts, MA 01003 (United States); Lundsager, Per; Bindner, Henrik; Cronin, Tom; Noergaard, Per [Riseo National Laboratory, P.O. Box 49, Frederiksborgvej 399, 4000 Roskilde (Denmark); Ruddell, Alan [Council for the Central Laboratory of the Research Councils, Rutherford Appleton Laboratory, Energy Research Unit, Chilton, OX11 0QX Didcot (United Kingdom); Perujo, Adolfo; Douglas, Kevin [E.C. Joint Research Centre, Institute for Environment and Sustainability, 21020 Ispra VA (Italy); Rodrigues, Carlos; Joyce, Antonio [INETI, Department of Renewable Energy, Estrada do Paco de Lumiar 22, 1649-038 Lisbon (Portugal); Tselepis, Stathis [Center for Renewable Energy Sources, 19th km Marathonos Ave., 19009 Pikermi (Greece); Borg, Nico van der; Nieuwenhout, Frans [The Netherlands Energy Research Foundation, P.O. Box 1, 1755 ZG Petten (Netherlands); Wilmot, Nigel [Research Institute for Sustainable Energy, Murdoch University, South Street, 6150 Perth (Australia); Mattera, Florence [Commissariat a l' Energetie Atomicque, Groupement Energetique de Cadarache, 38054 Grenoble (France)

    2007-11-15

    Operating conditions in off-grid renewable energy systems (RES) vary significantly in different applications and locations. To describe RES and the operating conditions of their components it is useful to define categories of similar operating conditions. Categories can also be used for lifetime considerations of RES components, for making recommendations and for analysing the properties and performance of a RES and its components. Categories support system designers and an economic analysis. This paper describes the process and the results of creating RES categories of similar operating conditions for batteries. Categories are defined in such a way that batteries belonging to the same category are subjected to similar operating conditions and a similar combination of stress factors. The results provide a comprehensive overview of battery operating conditions in existing off-grid renewable energy systems. This work is part of the EU research project Benchmarking. (author)

  13. Operating conditions of batteries in off-grid renewable energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Svoboda, Vojtech; Wenzl, Heinz; Kaiser, Rudi; Jossen, Andreas; Baring-Gould, Ian; Manwell, James; Lundsager, Per; Bindner, Henrik; Cronin, Tom; Nørgård, Per; Ruddell, Alan; Perujo, Adolfo; Douglas, Kevin; Rodrigues, Carlos; Joyce, António; Tselepis, Stathis; van der Borg, Nico; Nieuwenhout, Frans; Wilmot, Nigel; Mattera, Florence; Sauer, Dirk Uwe

    2007-11-01

    Operating conditions in off-grid renewable energy systems (RES) vary significantly in different applications and locations. To describe RES and the operating conditions of their components it is useful to define categories of similar operating conditions. Categories can also be used for lifetime considerations of RES components, for making recommendations and for analysing the properties and performance of a RES and its components. Categories support system designers and an economic analysis. This paper describes the process and the results of creating RES categories of similar operating conditions for batteries. Categories are defined in such a way that batteries belonging to the same category are subjected to similar operating conditions and a similar combination of stress factors. The results provide a comprehensive overview of battery operating conditions in existing off-grid renewable energy systems. This work is part of the EU research project Benchmarking.

  14. How to Establish Local Renewable Energy Scenarios in the Context of National Energy Systems

    DEFF Research Database (Denmark)

    Thellufsen, Jakob Zinck

    2014-01-01

    In the transition to 100% renewable energy systems, the local and regional implementation of renewable energy becomes essential. To implement energy systems that fulfill national targets, local investments have to be made creating a need for local energy planning. However, challenges emerge when...... local energy plans must be related to each other and to national targets. For instance, in terms of the division of resources between the countryside and cities, the amount of biomass to be used, and the placement of wind turbines. If local plans do not include the context of surrounding energy systems...... and only optimise locally, the consequences might be national sub-optimisation, including excessive biomass use, wind turbines in non-favourable positions, and the misalignment of resources between the open land and the cities. Thus, there is a risk that these necessary local plans can lead...

  15. Operating conditions of batteries in off-grid renewable energy systems

    DEFF Research Database (Denmark)

    Svoboda, V.; Wenzl, H.; Kaiser, R.

    2007-01-01

    Operating conditions in off-grid renewable energy systems (RES) vary significantly in different applications and locations. To describe RES and the operating conditions of their components it is useful to define categories of similar operating conditions. Categories can also be used for lifetime...... considerations of RES components, for making recommendations and for analysing the properties and performance of a RES and its components. Categories support system designers and an economic analysis. This paper describes the process and the results of creating RES categories of similar operating conditions...... for batteries. Categories are defined in such a way that batteries belonging to the same category are subjected to similar operating conditions and a similar combination of stress factors. The results provide a comprehensive overview of battery operating conditions in existing off-grid renewable energy systems...

  16. DC Distributed Power Systems. Analysis, Design and Control for a Renewable Energy System

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Per

    2002-12-01

    Renewable energy systems are likely to become wide spread in the future due to environmental demands. As a consequence of the dispersed nature of renewable energy systems, this implies that there will be a distributed generation of electric power. Since most of the distributed electrical energy sources do not provide their electric power at line frequency and voltage, a DC bus is a useful common connection for several such sources. Due to the differences in output voltage among the sources, depending on both the type of source and their actual operating point, the sources are connected to the DC power system via power electronic converters. The intention behind the presented work is not to replace the existing AC power system, but to include local DC power systems. The AC and DC power systems are connected at some points in the network. The renewable energy sources are weak compared to the present hydro power and nuclear power plants, resulting in a need of power conditioning before the renewable energy is fed to the transmission lines. The benefit of such an approach is that power conditioning is applied on a central level, i.e. at the interface between the AC and DC power systems. The thesis starts with an overview of related work. Present DC transmission systems are discussed and investigated in simulations. Then, different methods for load sharing and voltage control are discussed. Especially, the voltage droop control scheme is examined thoroughly. Since the droop control method does not require any high-speed communication between sources and loads, this is considered the most suitable for DC distributed power systems. The voltage feed back design of the controller also results in a specification of the DC bus capacitors (equivalents to DC link capacitors of single converters) needed for filtering. If the converters in the DC distribution system are equipped with capacitors selected from this design criterion and if the DC bus impedance is neglected, the

  17. DC Distributed Power Systems. Analysis, Design and Control for a Renewable Energy System

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Per

    2002-12-01

    Renewable energy systems are likely to become wide spread in the future due to environmental demands. As a consequence of the dispersed nature of renewable energy systems, this implies that there will be a distributed generation of electric power. Since most of the distributed electrical energy sources do not provide their electric power at line frequency and voltage, a DC bus is a useful common connection for several such sources. Due to the differences in output voltage among the sources, depending on both the type of source and their actual operating point, the sources are connected to the DC power system via power electronic converters. The intention behind the presented work is not to replace the existing AC power system, but to include local DC power systems. The AC and DC power systems are connected at some points in the network. The renewable energy sources are weak compared to the present hydro power and nuclear power plants, resulting in a need of power conditioning before the renewable energy is fed to the transmission lines. The benefit of such an approach is that power conditioning is applied on a central level, i.e. at the interface between the AC and DC power systems. The thesis starts with an overview of related work. Present DC transmission systems are discussed and investigated in simulations. Then, different methods for load sharing and voltage control are discussed. Especially, the voltage droop control scheme is examined thoroughly. Since the droop control method does not require any high-speed communication between sources and loads, this is considered the most suitable for DC distributed power systems. The voltage feed back design of the controller also results in a specification of the DC bus capacitors (equivalents to DC link capacitors of single converters) needed for filtering. If the converters in the DC distribution system are equipped with capacitors selected from this design criterion and if the DC bus impedance is neglected, the

  18. Advancing System Flexibility for High Penetration Renewable Integration (Chinese Translation)

    Energy Technology Data Exchange (ETDEWEB)

    Milligan, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Frew, Bethany [National Renewable Energy Lab. (NREL), Golden, CO (United States); Zhou, Ella [National Renewable Energy Lab. (NREL), Golden, CO (United States); Arent, Douglas J. [Joint Inst. for Strategic Energy Analysis, Golden, CO (United States)

    2015-10-01

    This is a Chinese translation of NREL/TP-6A20-64864. This report summarizes some of the issues discussed during the engagement on power system flexibility. By design, the focus is on flexibility options used in the United States. Exploration of whether and how U.S. experiences can inform Chinese energy planning will be part of the continuing project, and will benefit from the knowledge base provided by this report. We believe the initial stage of collaboration represented in this report has successfully started a process of mutual understanding, helping Chinese researchers to begin evaluating how lessons learned in other countries might translate to China's unique geographic, economic, social, and political contexts.

  19. Model documentation renewable fuels module of the National Energy Modeling System

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    This report documents the objectives, analytical approach, and design of the National Energy Modeling System (NEMS) Renewable Fuels Module (RFM) as it relates to the production of the 1995 Annual Energy Outlook (AEO95) forecasts. The report catalogues and describes modeling assumptions, computational methodologies, data inputs, and parameter estimation techniques. A number of offline analyses used in lieu of RFM modeling components are also described. The RFM consists of six analytical submodules that represent each of the major renewable energy resources--wood, municipal solid waste (MSW), solar energy, wind energy, geothermal energy, and alcohol fuels. The RFM also reads in hydroelectric facility capacities and capacity factors from a data file for use by the NEMS Electricity Market Module (EMM). The purpose of the RFM is to define the technological, cost and resource size characteristics of renewable energy technologies. These characteristics are used to compute a levelized cost to be competed against other similarly derived costs from other energy sources and technologies. The competition of these energy sources over the NEMS time horizon determines the market penetration of these renewable energy technologies. The characteristics include available energy capacity, capital costs, fixed operating costs, variable operating costs, capacity factor, heat rate, construction lead time, and fuel product price.

  20. Stochastic analysis and simulation of hydrometeorological processes for optimizing hybrid renewable energy systems

    Science.gov (United States)

    Tsekouras, Georgios; Ioannou, Christos; Efstratiadis, Andreas; Koutsoyiannis, Demetris

    2013-04-01

    The drawbacks of conventional energy sources including their negative environmental impacts emphasize the need to integrate renewable energy sources into energy balance. However, the renewable sources strongly depend on time varying and uncertain hydrometeorological processes, including wind speed, sunshine duration and solar radiation. To study the design and management of hybrid energy systems we investigate the stochastic properties of these natural processes, including possible long-term persistence. We use wind speed and sunshine duration time series retrieved from a European database of daily records and we estimate representative values of the Hurst coefficient for both variables. We conduct simultaneous generation of synthetic time series of wind speed and sunshine duration, on yearly, monthly and daily scale. To this we use the Castalia software system which performs multivariate stochastic simulation. Using these time series as input, we perform stochastic simulation of an autonomous hypothetical hybrid renewable energy system and optimize its performance using genetic algorithms. For the system design we optimize the sizing of the system in order to satisfy the energy demand with high reliability also minimizing the cost. While the simulation scale is the daily, a simple method allows utilizing the subdaily distribution of the produced wind power. Various scenarios are assumed in order to examine the influence of input parameters, such as the Hurst coefficient, and design parameters such as the photovoltaic panel angle.

  1. A New Energy Management Technique for PV/Wind/Grid Renewable Energy System

    Directory of Open Access Journals (Sweden)

    Onur Ozdal Mengi

    2015-01-01

    Full Text Available An intelligent energy management system (IEMS for maintaining the energy sustainability in renewable energy systems (RES is introduced here. It consists of wind and photovoltaic (PV solar panels are established and used to test the proposed IEMS. Since the wind and solar sources are not reliable in terms of sustainability and power quality, a management system is required for supplying the load power demand. The power generated by RES is collected on a common DC bus as a renewable green power pool to be used for supplying power to loads. The renewable DC power bus is operated in a way that there is always a base power available for permanent loads. Then the additional power requirement is supplied from either wind or PV or both depending upon the availability of these power sources. The decision about operating these systems is given by an IEMS with fuzzy logic decision maker proposed in this study. Using the generated and required power information from the wind/PV and load sides, the fuzzy reasoning based IEMS determines the amount of power to be supplied from each or both sources. Besides, the IEMS tracks the maximum power operating point of the wind energy system.

  2. Hybrid renewable energy system application for electricity and heat supply of a residential building

    Directory of Open Access Journals (Sweden)

    Nakomčić-Smaragdakis Branka B.

    2016-01-01

    Full Text Available Renewable and distributed energy systems could provide a solution to the burning issue of reliable and clean supply of energy, having in mind current state and future predictions for population growth and fossil fuel scarcity. Hybrid renewable energy systems are novelty in Serbia and warrant further detailed research. The aim of this paper is to analyze the application of renewable energy sources(RES for electricity and heat supply of a typical household in Serbia, as well as the cost-effectiveness of the proposed system. The influence of feed-in tariff change on the value of the investment is analyzed. Small, grid-connected hybrid system (for energy supply of a standard household, consisting of geothermal heat pump for heating/cooling, solar photovoltaic panels and small wind turbine for power supply is analyzed as a case study. System analysis was conducted with the help of RETScreen software. Results of techno-economics analysis have shown that investing in geothermal heat pump and photovoltaic panels is cost-effective, while that is not the case with small wind turbine.

  3. Technical evaluation of two 6-kW mono-Si photovoltaic systems at the National Renewable Energy Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Dyk, E.E. van; Strand, T.; Hansen, R. [National Renewable Energy Lab., Golden, CO (United States)

    1996-05-01

    This paper presents an analysis of performance data on the two 6-kW{sub ac} grid-connected photovoltaic systems at the National Renewable Energy Laboratory (NREL). The performance parameters analyzed include dc and ac power, aperture efficiency, energy, capacity factor and performance index which are compared to plane-of-array irradiance, ambient temperature, and back-of-module temperature as a function of time, either daily or monthly. Power ratings of the systems were also obtained for data corresponding to different test conditions. This study has shown, in addition to expected seasonal trends, that system monitoring is a valuable tool in assessing performance and detecting faulty equipment. In addition, methods applied for this study may be used to evaluate and compare systems employing different cell technologies.

  4. Energy system modelling – interactions and synergies in a highly renewable Pan-European power system

    Directory of Open Access Journals (Sweden)

    Weitemeyer Stefan

    2014-01-01

    Full Text Available It is very likely that the European power supply system will be transformed in the next decades to a low carbon system based almost entirely on Renewable Energy Sources (RES. However, due to the natural fluctuations of the most powerful RES (wind and solar energy, it is also very likely that a significant amount of balancing and controllable backup power capacities will be required to ensure a stable grid operation. This implies high additional investments and operating costs. Therefore this work provides an overview of potential options and possibly more cost-effective alternatives to the installation of costly storage capacities, namely grid expansion, demand side management, an optimised mix between different RES as well as the use of overcapacities. Furthermore, the paper provides an approximation of the maximum RES penetration of the German electricity system in the absence of significant storage capacities. Our calculations show that from a numerical perspective on average approximately half of the load can be met by RES if flexible conventional power stations would provide the remaining electricity demand. However, in a 100% RES scenario a significant amount of storage capacities as well as limited overcapacities are required to ensure a reliable electricity supply.

  5. Energy system modelling - interactions and synergies in a highly renewable Pan-European power system

    Science.gov (United States)

    Weitemeyer, Stefan; Kleinhans, David; Vogt, Thomas; Agert, Carsten

    2014-12-01

    It is very likely that the European power supply system will be transformed in the next decades to a low carbon system based almost entirely on Renewable Energy Sources (RES). However, due to the natural fluctuations of the most powerful RES (wind and solar energy), it is also very likely that a significant amount of balancing and controllable backup power capacities will be required to ensure a stable grid operation. This implies high additional investments and operating costs. Therefore this work provides an overview of potential options and possibly more cost-effective alternatives to the installation of costly storage capacities, namely grid expansion, demand side management, an optimised mix between different RES as well as the use of overcapacities. Furthermore, the paper provides an approximation of the maximum RES penetration of the German electricity system in the absence of significant storage capacities. Our calculations show that from a numerical perspective on average approximately half of the load can be met by RES if flexible conventional power stations would provide the remaining electricity demand. However, in a 100% RES scenario a significant amount of storage capacities as well as limited overcapacities are required to ensure a reliable electricity supply.

  6. Analysis of essential pathways for self-renewal in common marmoset embryonic stem cells

    Directory of Open Access Journals (Sweden)

    Takenobu Nii

    2014-01-01

    Full Text Available Common marmoset (CM is widely recognized as a useful non-human primate for disease modeling and preclinical studies. Thus, embryonic stem cells (ESCs derived from CM have potential as an appropriate cell source to test human regenerative medicine using human ESCs. CM ESCs have been established by us and other groups, and can be cultured in vitro. However, the growth factors and downstream pathways for self-renewal of CM ESCs are largely unknown. In this study, we found that basic fibroblast growth factor (bFGF rather than leukemia inhibitory factor (LIF promoted CM ESC self-renewal via the activation of phosphatidylinositol-3-kinase (PI3K-protein kinase B (AKT pathway on mouse embryonic fibroblast (MEF feeders. Moreover, bFGF and transforming growth factor β (TGFβ signaling pathways cooperatively maintained the undifferentiated state of CM ESCs under feeder-free condition. Our findings may improve the culture techniques of CM ESCs and facilitate their use as a preclinical experimental resource for human regenerative medicine.

  7. ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment.

    Directory of Open Access Journals (Sweden)

    William B Hamilton

    Full Text Available Activation of the FGF-ERK pathway is necessary for naïve mouse embryonic stem (ES cells to exit self-renewal and commit to early differentiated lineages. Here we show that genetic ablation of Erk2, the predominant ERK isozyme expressed in ES cells, results in hyper-phosphorylation of ERK1, but an overall decrease in total ERK activity as judged by substrate phosphorylation and immediate-early gene (IEG induction. Normal induction of this subset of canonical ERK targets, as well as p90RSK phosphorylation, was rescued by transgenic expression of either ERK1 or ERK2 indicating a degree of functional redundancy. In contrast to previously published work, Erk2-null ES cells exhibited no detectable defect in lineage specification to any of the three germ layers when induced to differentiate in either embryoid bodies or in defined neural induction conditions. However, under self-renewing conditions Erk2-null ES cells express increased levels of the pluripotency-associated transcripts, Nanog and Tbx3, a decrease in Nanog-GFP heterogeneity, and exhibit enhanced self-renewal in colony forming assays. Transgenic add-back of ERK2 is capable of restoring normal pluripotent gene expression and self-renewal capacity. We show that ERK2 contributes to the destabilization of ES cell self-renewal by reducing expression of pluripotency genes, such as Nanog, but is not specifically required for the early stages of germ layer specification.

  8. Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.

    Directory of Open Access Journals (Sweden)

    Geqiang Li

    Full Text Available BACKGROUND: Grb2-associated binding (Gab adapter proteins play major roles in coordinating signaling downstream of hematopoietic cytokine receptors. In hematopoietic cells, Gab2 can modulate phosphatidylinositol-3 kinase and mitogen associated protein kinase activities and regulate the long-term multilineage competitive repopulating activity of hematopoietic stem cells (HSCs. Gab2 may also act in a linear pathway upstream or downstream of signal transducer and activator of transcription-5 (STAT5, a major positive regulator of HSC function. Therefore, we aimed to determine whether Gab2 and STAT5 function in hematopoiesis in a redundant or non-redundant manner. METHODOLOGY/PRINCIPAL FINDINGS: To do this we generated Gab2 mutant mice with heterozygous and homozygous deletions of STAT5. In heterozygous STAT5 mutant mice, deficiencies in HSC/multipotent progenitors were reflected by decreased long-term repopulating activity. This reduction in repopulation function was mirrored in the reduced growth response to early-acting cytokines from sorted double mutant c-Kit(+Lin(-Sca-1(+ (KLS cells. Importantly, in non-ablated newborn mice, the host steady-state engraftment ability was impaired by loss of Gab2 in heterozygous STAT5 mutant background. Fetal liver cells isolated from homozygous STAT5 mutant mice lacking Gab2 showed significant reduction in HSC number (KLS CD150(+CD48(-, reduced HSC survival, and dramatic loss of self-renewal potential as measured by serial transplantation. CONCLUSIONS/SIGNIFICANCE: These data demonstrate new functions for Gab2 in hematopoiesis in a manner that is non-redundant with STAT5. Furthermore, important synergy between STAT5 and Gab2 was observed in HSC self-renewal, which might be exploited to optimize stem cell-based therapeutics.

  9. Power Electronics – Key Technology for Renewable Energy Systems – Status and Future

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Yang, Yongheng; Ma, Ke

    2013-01-01

    , distribution and use of the energy should be as technological efficient as possible and incentives to save energy at the end-user should also be streng-thened. In order to realize the transition smoothly and effectively, energy conversion systems, currently based on power electronics technology, will again...... play an essential role. Using highly efficient power electronics in power generation, power transmission/ distribution and end-user application, together with advanced control solutions, can pave the way for renewable energies. In view of this, some of the most emerging renewable energies, e.g. wind...... energy and photovoltaic, which by means of power electronics are changing character as a major part in the electricity generation, are explored in this paper. Issues like technology development, implementation, power converter technologies, control of the systems, and synchronization are addressed...

  10. Renewable Electric Plant Information System user interface manual: Paradox 7 Runtime for Windows

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The Renewable Electric Plant Information System (REPiS) is a comprehensive database with detailed information on grid-connected renewable electric plants in the US. The current version, REPiS3 beta, was developed in Paradox for Windows. The user interface (UI) was developed to facilitate easy access to information in the database, without the need to have, or know how to use, Paradox for Windows. The UI is designed to provide quick responses to commonly requested sorts of the database. A quick perusal of this manual will familiarize one with the functions of the UI and will make use of the system easier. There are six parts to this manual: (1) Quick Start: Instructions for Users Familiar with Database Applications; (2) Getting Started: The Installation Process; (3) Choosing the Appropriate Report; (4) Using the User Interface; (5) Troubleshooting; (6) Appendices A and B.

  11. Storage and balancing synergies in a fully or highly renewable pan-European power system

    DEFF Research Database (Denmark)

    Rasmussen, Morten Grud; Bruun Andresen, Gorm; Greiner, Martin

    2012-01-01

    Through a parametric time-series analysis of eight years of hourly data, we quantify the storage size and balancing energy needs for highly and fully renewable European power systems for different levels and mixes of wind and solar energy. By applying a dispatch strategy that minimizes...... that combined with a low-efficiency hydrogen storage and a level of balancing equal to what is today provided by storage lakes, it is sufficient to meet the European electricity demand in a fully renewable power system where the average power generation from combined wind and solar exceeds the demand by only...... the balancing energy needs for a given storage size, the interplay between storage and balancing is quantified, providing a hard upper limit on their synergy. An efficient but relatively small storage reduces balancing energy needs significantly due to its influence on intra-day mismatches. Furthermore, we show...

  12. Impact of forecast errors on expansion planning of power systems with a renewables target

    DEFF Research Database (Denmark)

    Pineda, Salvador; Morales González, Juan Miguel; Boomsma, Trine Krogh

    2015-01-01

    This paper analyzes the impact of production forecast errors on the expansion planning of a power system and investigates the influence of market design to facilitate the integration of renewable generation. For this purpose, we propose a programming modeling framework to determine the generation...... and transmission expansion plan that minimizes system-wide investment and operating costs, while ensuring a given share of renewable generation in the electricity supply. Unlike existing ones, this framework includes both a day-ahead and a balancing market so as to capture the impact of both production forecasts...... and the associated prediction errors. Within this framework, we consider two paradigmatic market designs that essentially differ in whether the day-ahead generation schedule and the subsequent balancing re-dispatch are co-optimized or not. The main features and results of the model set-ups are discussed using...

  13. Analysis of renewable energy sources and electric vehicle penetration into energy systems predominantly based on lignite

    Science.gov (United States)

    Dedinec, A.; Jovanovski, B.; Gajduk, A.; Markovska, N.; Kocarev, L.

    2016-05-01

    We consider an integration of renewable energy into transport and electricity sectors through vehicle to grid (V2G) technologies for an energy system that is predominantly based on lignite. The national energy system of Macedonia is modeled using EnergyPLAN which integrates energy for electricity, transport and heat, and includes hourly fluctuations in human needs and the environment. We show that electric-vehicles can provide the necessary storage enabling a fully renewable energy profile for Macedonia that can match the country's growing demand for energy. Furthermore, a large penetration of electric vehicles leads to a dramatic reduction of 47% of small particles and other air pollutants generated by car traffic in 2050.

  14. Analysis of renewable energy sources and electric vehicle penetration into energy systems predominantly based on lignite

    CERN Document Server

    Dedinec, Aleksandar; Gajduk, Andrej; Markovska, Natasa; Kocarev, Ljupco

    2016-01-01

    We consider an integration of renewable energy into transport and electricity sectors through vehicle to grid (V2G) technologies for an energy system that is predominantly based on lignite. The national energy system of Macedonia is modeled using EnergyPLAN which integrates energy for electricity, transport and heat, and includes hourly fluctuations in human needs and the environment. We show that electric-vehicles can provide the necessary storage enabling a fully renewable energy profile for Macedonia that can match the country's growing demand for energy. Furthermore, a large penetration of electric vehicles leads to a dramatic reduction of 47% of small particles and other air pollutants generated by car traffic in 2050.

  15. Initial Investigation of a Novel Thermal Storage Concept as Part of a Renewable Energy System

    Science.gov (United States)

    2013-06-01

    Handbook of Batteries , 3rd Edn., D. Linden and T.B. Reddy, Eds. New York, NY: McGraw-Hill Professional, 2002, pp. 23.1-23.88. [6] “Electropaedia...RENEWABLE ENERGY SYSTEM 5. FUNDING NUMBERS 6. AUTHOR( S ) Lindsay M. Olsen 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Naval Postgraduate School...Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME( S ) AND ADDRESS(ES) N/A 10

  16. Two major gate-keepers in the self-renewal of neural stem cells: Erk1/2 and PLCγ1 in FGFR signaling

    Directory of Open Access Journals (Sweden)

    Lee Jin-A

    2009-06-01

    Full Text Available Abstract Neural stem cells are undifferentiated precursor cells that proliferate, self-renew, and give rise to neuronal and glial lineages. Understanding the molecular mechanisms underlying their self-renewal is an important aspect in neural stem cell biology. The regulation mechanisms governing self-renewal of neural stem cells and the signaling pathways responsible for the proliferation and maintenance of adult stem cells remain largely unknown. In this issue of Molecular Brain [Ma DK et al. Molecular genetic analysis of FGFR1 signaling reveals distinct roles of MAPK and PLCγ1 activation for self-renewal of adult neural stem cells. Molecular Brain 2009, 2:16], characterized the different roles of MAPK and PLCγ1 in FGFR1 signaling in the self-renewal of neural stem cells. These novel findings provide insights into basic neural stem cell biology and clinical applications of potential stem-cell-based therapy.

  17. Self-renewal and pluripotency is maintained in human embryonic stem cells by co-culture with human fetal liver stromal cells expressing hypoxia inducible factor 1alpha.

    Science.gov (United States)

    Ji, Lei; Liu, Yu-xiao; Yang, Chao; Yue, Wen; Shi, Shuang-shuang; Bai, Ci-xian; Xi, Jia-fei; Nan, Xue; Pei, Xue-Tao

    2009-10-01

    Human embryonic stem (hES) cells are typically maintained on mouse embryonic fibroblast (MEF) feeders or with MEF-conditioned medium. However, these xenosupport systems greatly limit the therapeutic applications of hES cells because of the risk of cross-transfer of animal pathogens. The stem cell niche is a unique tissue microenvironment that regulates the self-renewal and differentiation of stem cells. Recent evidence suggests that stem cells are localized in the microenvironment of low oxygen. We hypothesized that hypoxia could maintain the undifferentiated phenotype of embryonic stem cells. We have co-cultured a human embryonic cell line with human fetal liver stromal cells (hFLSCs) feeder cells stably expressing hypoxia-inducible factor-1 alpha (HIF-1alpha), which is known as the key transcription factor in hypoxia. The results suggested HIF-1alpha was critical for preventing differentiation of hES cells in culture. Consistent with this observation, hypoxia upregulated the expression of Nanog and Oct-4, the key factors expressed in undifferentiated stem cells. We further demonstrated that HIF-1alpha could upregulate the expression of some soluble factors including bFGF and SDF-1alpha, which are released into the microenvironment to maintain the undifferentiated status of hES cells. This suggests that the targets of HIF-1alpha are secreted soluble factors rather than a cell-cell contact mechanism, and defines an important mechanism for the inhibition of hESCs differentiation by hypoxia. Our findings developed a transgene feeder co-culture system and will provide a more reliable alternative for future therapeutic applications of hES cells.

  18. SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

    Directory of Open Access Journals (Sweden)

    Chi-Hsien Peng

    2010-06-01

    Full Text Available Retinal stem cells bear potency of proliferation, self-renewal, and differentiation into many retinal cells. Utilizing appropriate sensors one can effectively detect the self-renewal and aging process abilities. Silencing information regulator (SirT1, a member of the sirtuin family, is a NAD-dependent histone deacetylase and an essential mediator for longevity in normal cells by calorie restriction. We firstly investigate the SirT1 mRNA expression in retinal stem cells from rats and 19 human eyes of different ages. Results revealed that SirT1 expression was significantly decreased in in vivo aged eyes, associated with poor self-renewal abilities. Additionally, SirT1 mRNA levels were dose-dependently increased in resveratrol- treated retinal stem cells. The expression of SirT1 on oxidative stress-induced damage was significantly decreased, negatively correlated with the level of intracellular reactive oxygen species production. Treatment with resveratrol could effectively further reduce oxidative stress induced by H2O2 treatment in retinal stem cells. Importantly, the anti-oxidant effects of resveratrol in H2O2-treated retinal stem cells were significantly abolished by knockdown of SirT1 expression (sh-SirT1. SirT1 expression provides a feasible sensor in assessing self-renewal and aging process in retinal stem cells. Resveratrol can prevent reactive oxygen species-induced damages via increased retinal SirT1 expression.

  19. Switch: a planning tool for power systems with large shares of intermittent renewable energy.

    Science.gov (United States)

    Fripp, Matthias

    2012-06-05

    Wind and solar power are highly variable, so it is it unclear how large a role they can play in future power systems. This work introduces a new open-source electricity planning model--Switch--that identifies the least-cost strategy for using renewable and conventional generators and transmission in a large power system over a multidecade period. Switch includes an unprecedented amount of spatial and temporal detail, making it possible to address a new type of question about the optimal design and operation of power systems with large amounts of renewable power. A case study of California for 2012-2027 finds that there is no maximum possible penetration of wind and solar power--these resources could potentially be used to reduce emissions 90% or more below 1990 levels without reducing reliability or severely raising the cost of electricity. This work also finds that policies that encourage customers to shift electricity demand to times when renewable power is most abundant (e.g., well-timed charging of electric vehicles) could make it possible to achieve radical emission reductions at moderate costs.

  20. Optimal Operation of the Integrated Electrical and Heating Systems to Accommodate the Intermittent Renewable Sources

    DEFF Research Database (Denmark)

    Li, Jinghua; Fang, Jiakun; Zeng, Qing

    2016-01-01

    The integration of electrical and heating systems has great potential to enhance the flexibility of power systems to accommodate more renewable power such as the wind and solar. This study was to investigate an optimal way to integrate the energy of both systems in urban areas. The amount of energy....... The mathematic formulation of the optimization problem was detailed as a large-scale non-linear program (LSNLP) in this paper. A decomposition-coordination algorithm was proposed to solve this LSNLP. At last, a 6-bus electrical power system with 31-node heating transmission system was studied to demonstrate...... conversion between the electrical system and heating system was optimally decided so that the demand within both systems could be met at the least operational cost. Besides, the best node to join with the electrical system and heating system was chosen by consideration of the energy transmission loss...

  1. mir-300 promotes self-renewal and inhibits the differentiation of glioma stem-like cells

    KAUST Repository

    Zhang, Daming

    2014-01-28

    MicroRNAs (miRNAs) are small noncoding RNAs that have been critically implicated in several human cancers. miRNAs are thought to participate in various biological processes, including proliferation, cell cycle, apoptosis, and even the regulation of the stemness properties of cancer stem cells. In this study, we explore the potential role of miR-300 in glioma stem-like cells (GSLCs). We isolated GSLCs from glioma biopsy specimens and identified the stemness properties of the cells through neurosphere formation assays, multilineage differentiation ability analysis, and immunofluorescence analysis of glioma stem cell markers. We found that miR-300 is commonly upregulated in glioma tissues, and the expression of miR-300 was higher in GSLCs. The results of functional experiments demonstrated that miR-300 can enhance the self-renewal of GSLCs and reduce differentiation toward both astrocyte and neural fates. In addition, LZTS2 is a direct target of miR-300. In conclusion, our results demonstrate the critical role of miR-300 in GSLCs and its functions in LZTS2 inhibition and describe a new approach for the molecular regulation of tumor stem cells. © 2014 Springer Science+Business Media.

  2. Layered double hydroxide nanoparticles promote self-renewal of mouse embryonic stem cells through the PI3K signaling pathway

    Science.gov (United States)

    Wu, Youjun; Zhu, Rongrong; Zhou, Yang; Zhang, Jun; Wang, Wenrui; Sun, Xiaoyu; Wu, Xianzheng; Cheng, Liming; Zhang, Jing; Wang, Shilong

    2015-06-01

    Embryonic stem cells (ESCs) hold great potential for regenerative medicine due to their two unique characteristics: self-renewal and pluripotency. Several groups of nanoparticles have shown promising applications in directing the stem cell fate. Herein, we investigated the cellular effects of layered double hydroxide nanoparticles (LDH NPs) on mouse ESCs (mESCs) and the associated molecular mechanisms. Mg-Al-LDH NPs with an average diameter of ~100 nm were prepared by hydrothermal methods. To determine the influences of LDH NPs on mESCs, cellular cytotoxicity, self-renewal, differentiation potential, and the possible signaling pathways were explored. Evaluation of cell viability, lactate dehydrogenase release, ROS generation and apoptosis demonstrated the low cytotoxicity of LDH NPs. The alkaline phosphatase activity and the expression of pluripotency genes in mESCs were examined, which indicated that exposure to LDH NPs could support self-renewal and inhibit spontaneous differentiation of mESCs under feeder-free culture conditions. The self-renewal promotion was further proved to be independent of the leukemia inhibitory factor (LIF). Furthermore, cells treated with LDH NPs maintained the potential to differentiate into all three germ layers both in vitro and in vivo through formation of embryoid bodies and teratomas. In addition, we observed that LDH NPs initiated the activation of the PI3K/Akt pathway, while treatment with the PI3K inhibitor LY294002 could block the effects of LDH NPs on mESCs. The results confirmed that the promotion of self-renewal by LDH NPs was associated with activation of the PI3K/Akt signaling pathway. Altogether, our studies identified a new role of LDH NPs in maintaining self-renewal of mouse ES cells which could potentially be applied in stem cell research.Embryonic stem cells (ESCs) hold great potential for regenerative medicine due to their two unique characteristics: self-renewal and pluripotency. Several groups of nanoparticles

  3. Cogeneration and beyond: The need and opportunity for high efficiency, renewable community energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Gleason, T.C.J.

    1992-06-01

    The justification, strategies, and technology options for implementing advanced district heating and cooling systems in the United States are presented. The need for such systems is discussed in terms of global warming, ozone depletion, and the need for a sustainable energy policy. Strategies for implementation are presented in the context of the Public Utilities Regulatory Policies Act and proposed new institutional arrangements. Technology opportunities are highlighted in the areas of advanced block-scale cogeneration, CFC-free chiller technologies, and renewable sources of heating and cooling that are particularly applicable to district systems.

  4. Ac-dc Bus-interface Bi-directional Converters in Renewable Energy Systems

    OpenAIRE

    Dong, Dong

    2012-01-01

    This dissertation covers several issues related to the ac-dc bus-interface bi-directional converters in renewable energy systems. The dissertation explores a dc-electronic distribution system for residential and commercial applications with a focus on the design of an ac-dc bi-directional converter for such application. This converter is named as the â Energy Control Centerâ due to its unique role in the system. First, the impact of the unbalanced power from the ac grid, especially the ...

  5. Hybrid Systems of Distributed Generation with Renewable Sources: Modeling and Analysis of Their Operational Modes in Electric Power System

    Directory of Open Access Journals (Sweden)

    A. Gashimov

    2013-01-01

    Full Text Available The paper considers problems pertaining to modeling and simulation of operational hybrid system modes of the distributed generation comprising conventional sources – modular diesel generators, gas-turbine power units; and renewable sources – wind and solar power plants. Operational modes of the hybrid system have been investigated under conditions of electrical connection with electric power system and in case of its isolated operation. As a consequence

  6. Design for reliability in power electronics in renewable energy systems – status and future

    DEFF Research Database (Denmark)

    Wang, Huai; Blaabjerg, Frede; Ma, Ke

    2013-01-01

    Advances in power electronics enable efficient and flexible interconnection of renewable sources, loads and electric grids. While targets concerning efficiency of power converters are within reach, recent research endeavors to predict and improve their reliability to ensure high availability, low......, the lifetime prediction of reliability-critical components IGBT modules is discussed in a 2.3 MW wind power converter. Finally, the challenges and opportunities to achieve more reliable power electronic converters are discussed....... maintenance costs, and herefore, low Levelized-Cost-of-Energy (LCOE) of renewable energy systems. This paper presents the prior-art Design for Reliability (DFR) process for power converters and addresses the paradigm shift to Physics-of-Failure (PoF) approach and mission profile based analysis. Moreover...

  7. Optimal investment paths for future renewable based energy systems - Using the optimisation model Balmorel

    DEFF Research Database (Denmark)

    Karlsson, Kenneth Bernard; Meibom, Peter

    2008-01-01

    that with an oil price at 100 $/barrel, a CO2 price at40 €/ton and the assumed penetration of hydrogen in the transport sector, it is economically optimal to cover more than 95% of the primary energy consumption for electricity and district heat by renewables in 2050. When the transport sector is converted......This paper investigates a possible long term investment path for the Nordic energy system focussing on renewable energy in the supply sector and on hydrogen as the main fuel for transportation, covering up to 70% of all transport in 2050. The optimisation model Balmorel [Ravn H, et al. Balmorel......: A model for analyses of the electricity and CHP markets in the Baltic Sea Region. 〈www.Balmorel.com〉; 2001. [1

  8. Incentive-based Financial Support Scheme for Immature Renewable Energy Systems

    DEFF Research Database (Denmark)

    Andersen, Morten Thøtt; Frigaard, Peter Bak

    2015-01-01

    Most of today’s renewable energy systems rely heavily on investments as well as public financial support. This support is often given by means of a higher sales price for each kWh produced, i.e. feed-in tariffs (FITs), green certificates or Renewable Obligation Certificates (ROCs), or by a fixed...... amount, being a percentage of the construction costs of the facility. All these ways of financing have different downsides. The feed-in tariff based kWh prices have some incentives to improve the technology, but enables infeasible solutions to stay financially supported even while R&D is in status quo....... The fixed amount only helps with installation costs, which should not be an issue once the technology is sufficiently feasible. This means that the current ways of granting financial support all lack incentives for increasing production or decreasing construction costs. This paper presents a unique scheme...

  9. Evaluation of renewable energy potential using a GIS decision support system

    Energy Technology Data Exchange (ETDEWEB)

    Voivontas, D.; Assimacopoulos, D.; Mourelatos, A. [National Technical University of Athens, Section II : Process Analysis and Plant Design, Zografou Campus (Greece); Corominas, J. [ECOSERVEIS, Barcelona (Spain)

    1998-07-01

    A GIS Decision Support System has been developed for the evaluation of Renewable Energy Sources potential and the financial analysis of RE investments. A GIS database with data on wind, topography, urban areas, and special activities has been developed and used for the evaluation of theoretical potential through the spatially continuous mapping of Renewable Energy Sources. The available and technological potential are evaluated by the application of availability and technological restrictions. The evaluation of economical potential is performed by a precise estimation of the expected energy output and installation cost. The financial analysis based on the Internal Rate of Return, identifies the financial viability of alternative investments. The evaluation of wind energy potential for the island of Crete and the financial analysis of a wind park installation are presented as a case study. (author)

  10. RESRO: A spatio-temporal model to optimise regional energy systems emphasising renewable energies

    Directory of Open Access Journals (Sweden)

    Gadocha S.

    2012-10-01

    Full Text Available RESRO (Reference Energy System Regional Optimization optimises the simultaneous fulfilment of the heat and power demand in regional energy systems. It is a mixed-integer program realised in the modelling language GAMS. The model handles information on geographically disaggregated data describing heat demand and renewable energy potentials (e.g. biomass, solar energy, ambient heat. Power demand is handled spatially aggregated in an hourly time resolution within 8 type days. The major idea is to use a high-spatial, low-temporal heat resolution and a low-spatial, hightemporal power resolution with both demand levels linked with each other. Due to high transport losses the possibilities for heat transport over long distances are unsatisfying. Thus, the spatial, raster-based approach is used to identify and utilise renewable energy resources for heat generation close to the customers as well as to optimize district heating grids and related energy flows fed by heating plants or combined heat and power (CHP plants fuelled by renewables. By combining the heat and electricity sector within the model, it is possible to evaluate relationships between these energy fields such as the use of CHP or heat pump technologies and also to examine relationships between technologies such as solar thermal and photovoltaic facilities, which are in competition for available, suitable roof or ground areas.

  11. Self-renewal and pluripotency acquired through somatic reprogramming to human cancer stem cells.

    Directory of Open Access Journals (Sweden)

    Shogo Nagata

    Full Text Available Human induced pluripotent stem cells (iPSCs are reprogrammed by transient expression of transcription factors in somatic cells. Approximately 1% of somatic cells can be reprogrammed into iPSCs, while the remaining somatic cells are differentially reprogrammed. Here, we established induced pluripotent cancer stem-like cells (iCSCs as self-renewing pluripotent cell clones. Stable iCSC lines were established from unstable induced epithelial stem cell (iESC lines through re-plating followed by embryoid body formation and serial transplantation. iCSCs shared the expression of pluripotent marker genes with iPSCs, except for REX1 and LIN28, while exhibited the expression of somatic marker genes EMP1 and PPARγ. iESCs and iCSCs could generate teratomas with high efficiency by implantation into immunodeficient mice. The second iCSCs isolated from dissociated cells of teratoma from the first iCSCs were stably maintained, showing a gene expression profile similar to the first iCSCs. In the first and second iCSCs, transgene-derived Oct4, Sox2, Klf4, and c-Myc were expressed. Comparative global gene expression analyses demonstrated that the first iCSCs were similar to iESCs, and clearly different from human iPSCs and somatic cells. In iCSCs, gene expression kinetics of the core pluripotency factor and the Myc-related factor were pluripotent type, whereas the polycomb complex factor was somatic type. These findings indicate that pluripotent tumorigenicity can be conferred on somatic cells through up-regulation of the core pluripotency and Myc-related factors, prior to establishment of the iPSC molecular network by full reprogramming through down-regulation of the polycomb complex factor.

  12. Self-renewal and pluripotency acquired through somatic reprogramming to human cancer stem cells.

    Science.gov (United States)

    Nagata, Shogo; Hirano, Kunio; Kanemori, Michele; Sun, Liang-Tso; Tada, Takashi

    2012-01-01

    Human induced pluripotent stem cells (iPSCs) are reprogrammed by transient expression of transcription factors in somatic cells. Approximately 1% of somatic cells can be reprogrammed into iPSCs, while the remaining somatic cells are differentially reprogrammed. Here, we established induced pluripotent cancer stem-like cells (iCSCs) as self-renewing pluripotent cell clones. Stable iCSC lines were established from unstable induced epithelial stem cell (iESC) lines through re-plating followed by embryoid body formation and serial transplantation. iCSCs shared the expression of pluripotent marker genes with iPSCs, except for REX1 and LIN28, while exhibited the expression of somatic marker genes EMP1 and PPARγ. iESCs and iCSCs could generate teratomas with high efficiency by implantation into immunodeficient mice. The second iCSCs isolated from dissociated cells of teratoma from the first iCSCs were stably maintained, showing a gene expression profile similar to the first iCSCs. In the first and second iCSCs, transgene-derived Oct4, Sox2, Klf4, and c-Myc were expressed. Comparative global gene expression analyses demonstrated that the first iCSCs were similar to iESCs, and clearly different from human iPSCs and somatic cells. In iCSCs, gene expression kinetics of the core pluripotency factor and the Myc-related factor were pluripotent type, whereas the polycomb complex factor was somatic type. These findings indicate that pluripotent tumorigenicity can be conferred on somatic cells through up-regulation of the core pluripotency and Myc-related factors, prior to establishment of the iPSC molecular network by full reprogramming through down-regulation of the polycomb complex factor.

  13. Effects of Graphene Quantum Dots on the Self-Renewal and Differentiation of Mesenchymal Stem Cells.

    Science.gov (United States)

    Qiu, Jichuan; Li, Deshuai; Mou, Xiaoning; Li, Jianhua; Guo, Weibo; Wang, Shu; Yu, Xin; Ma, Baojin; Zhang, Shan; Tang, Wei; Sang, Yuanhua; Gil, Pilar Rivera; Liu, Hong

    2016-03-01

    The influence of graphene quantum dots (GQDs) on key characteristics of bone marrow derived mesenchymal stem cells (MSCs) phenotype (i.e., self-renewal, differentiation potential, and pluripotency) is systematically investigated in this work. First, the viability and impact of GQDs on the self-renewal potential of MSCs is evaluated in order to determine a threshold for the exposing dose. Second, GQDs uptake by MSCs is confirmed due to the excellent fluorescent properties of the particles. They exhibit a homogenous cytoplasmatic distribution that increases with the time and concentration. Third, the impact of GQDs on the osteogenic differentiation of MSCs is deeply characterized. An enhanced activity of alkaline phosphatase promoted by GQDs indicates early activation of osteogenesis. This is also confirmed upon GQD-induced up-regulation of phenotypically related osteogenic genes (Runx2, osteopontin, and osteocalcin) and specific biomarkers expression (osteopontin and osteocalcin). GQDs also effectively enhance the formation of calcium-rich deposits characteristics of osteoblasts. Furthermore, genes microarray results indicate that the enhanced osteogenic differentiation of MSCs by GQDs is in progress through a bone morphogenetic protein and transforming growth factor-β relative signaling pathways. Finally, intracytoplasmatic lipid detection shows that GQDs can also promote the adipogenic differentiation of MSCs, thus confirming the prevalence of their pluripotency potential.

  14. Ethanol Inactivated Mouse Embryonic Fibroblasts Maintain the Self-Renew and Proliferation of Human Embryonic Stem Cells

    OpenAIRE

    2015-01-01

    Conventionally, mouse embryonic fibroblasts (MEFs) inactivated by mitomycin C or irradiation were applied to support the self-renew and proliferation of human embryonic stem cells (hESCs). To avoid the disadvangtages of mitomycin C and irradiation, here MEFs were treated by ethanol (ET). Our data showed that 10% ET-inactivated MEFs (eiMEFs) could well maintain the self-renew and proliferation of hESCs. hESCs grown on eiMEFs expressed stem cell markers of NANOG, octamer-binding protein 4 (OCT4...

  15. Modelling and control of hybrid renewable energy system connected to AC grid

    Directory of Open Access Journals (Sweden)

    Sami Younsi

    2011-12-01

    Full Text Available This paper discusses the development of new control and supervision method for the optimum operation of hybrid renewable energy system (HRES connected to AC grid. The hybrid system consists of wind generator (WG, diesel generator (DG, and flywheel energy storage system (FESS. These subsystems are based on permanent magnet synchronous machines (PMSM which are controlled by sliding mode control. A supervisor control is designed to determine the energy transfer type of flywheel energy storage system (charging / discharging / no transfer energy, to take decision on diesel generators ON/OFF status, and to determine the reference powers for these two subsystems. The supervisor inputs are the power requested by AC grid, the power generated by wind generator, and the energy stored in flywheel. The objectives of the control and supervision for hybrid renewable energy system are to satisfy the power requested by AC grid, to manage the energy transfer between hybrid system and AC grid, to optimize the use of wind energy, and to reduce fuel of diesel generator. The system is simulated with Matlab – Simulink software and it gave good results.

  16. A Process for the Implementation of New Renewable Energy Systems in a Building by Considering Environmental and Economic Effect

    Directory of Open Access Journals (Sweden)

    Chan-Joong Kim

    2015-09-01

    Full Text Available The excessive use of fossil fuels has led to global warming and air pollution. To solve these problems, interest in new renewable energy system (NRE system has increased in recent years. In particular, photovoltaic, solar thermal heating, fuel cell and ground source heating system are actively implemented for achieving the zero energy building. Since the initial investment cost of the NRE system is quite expensive, it is necessary to conduct a feasibility study from the life cycle perspective. Therefore, this study aimed to develop the process for the implementation of NRE system in a building for the optimal design. This study was conducted with four steps: (i establishing the basic information for the system installation; (ii selecting key factors affecting system performances; (iii making possible alternatives of the system installation; and (iv selecting optimal system by considering environmental and economic effect. The proposed process could enable the final decision-maker to easily and accurately determine the optimal design of the NRE systems from the economic and environmental efficiency in the early design phase. The process could also be applied to any other NRE system and could be extended to any other country in the global environment.

  17. Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells.

    Science.gov (United States)

    Zhu, Thant S; Costello, Mark A; Talsma, Caroline E; Flack, Callie G; Crowley, Jessica G; Hamm, Lisa L; He, Xiaobing; Hervey-Jumper, Shawn L; Heth, Jason A; Muraszko, Karin M; DiMeco, Francesco; Vescovi, Angelo L; Fan, Xing

    2011-09-15

    One important function of endothelial cells in glioblastoma multiforme (GBM) is to create a niche that helps promote self-renewal of cancer stem-like cells (CSLC). However, the underlying molecular mechanism for this endothelial function is not known. Since activation of NOTCH signaling has been found to be required for propagation of GBM CSLCs, we hypothesized that the GBM endothelium may provide the source of NOTCH ligands. Here, we report a corroboration of this concept with a demonstration that NOTCH ligands are expressed in endothelial cells adjacent to NESTIN and NOTCH receptor-positive cancer cells in primary GBMs. Coculturing human brain microvascular endothelial cells (hBMEC) or NOTCH ligand with GBM neurospheres promoted GBM cell growth and increased CSLC self-renewal. Notably, RNAi-mediated knockdown of NOTCH ligands in hBMECs abrogated their ability to induce CSLC self-renewal and GBM tumor growth, both in vitro and in vivo. Thus, our findings establish that NOTCH activation in GBM CSLCs is driven by juxtacrine signaling between tumor cells and their surrounding endothelial cells in the tumor microenvironment, suggesting that targeting both CSLCs and their niche may provide a novel strategy to deplete CSLCs and improve GBM treatment.

  18. Planning renewable energy systems as part of Cradle-to-Cradle thinking on islands

    DEFF Research Database (Denmark)

    Smink, Carla; Hong, Lixuan; Kerndrup, Søren

    In a recently started EU Interreg IVB project ‘Cradle to Cradle Islands’, the cradle-to-cradle concept is going to be applied to a number of islands in the North Sea region, aiming at 100% renewable energy supply. The transformation of island energy systems is a challenging task, although islands...... and applies simple energy planning tools specific for each island, which are then used to start discussions on the islands on the pros and cons of renewable energy development, by providing information and real choices, and by starting social learning processes....... such as Samsø in Denmark have shown the way. While technologies exist and are readily available on the market to produce electricity and heat and to provide mobility, the difficulties typically lie in creating the institutional, economical and regulatory settings to make people and companies invest...... in these technologies. The specific challenge for islands is their dependence on energy supply from the mainland. Also, on most islands there are competing land uses for renewable energy from wind or biomass production. Areas are more sensitive and tourism and nature conservation often prohibits the development...

  19. Pathways to Decarbonization. Natural Gas and Renewable Energy. Lessons Learned from Energy System Stakeholders

    Energy Technology Data Exchange (ETDEWEB)

    Pless, Jacquelyn [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Arent, Douglas J. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Logan, Jeffrey [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Cochran, Jaquelin [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Zinaman, Owen [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Stark, Camila [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2015-04-30

    Ensuring the resilience, reliability, flexibility, and affordability of the U.S. electric grid is increasingly important as the country addresses climate change and an aging infrastructure. State and federal policy and actions by industry, non-profits, and others create a dynamic framework for achieving these goals. Three principle low-carbon generation technologies have formed the basis for multiple scenarios leading toward a low-carbon, resilient, and affordable power system. While there is no “silver bullet,” one avenue identified by key stakeholders is the opportunity to invest in natural gas (NG) and renewable resources, both of which offer abundant domestic resource bases and contribute to energy independence, carbon mitigation, and economic growth. NG and renewable electricity (RE) have traditionally competed for market share in the power sector, but there is a growing experience base and awareness for their synergistic use (Cochran et al. 2014). Building upon these observations and previous work, the Joint Institute for Strategic Energy Analysis (JISEA), in collaboration with the Center for the New Energy Economy and the Gas Technology Institute, convened a series of workshops in 2014 to explore NG and RE synergies in the U.S. power sector. This report captures key insights from the workshop series, Synergies of Natural Gas and Renewable Energy: 360 Degrees of Opportunity, as well as supporting economic valuation analyses conducted by JISEA researchers that quantify the value proposition of investing in NG and RE together as complements.

  20. The Realization of a Discrete-Time Deterministic Regulator for Energy Renewable Multivariable Systems

    Directory of Open Access Journals (Sweden)

    OBINABO, EDWIN CHUKWUDI

    2010-12-01

    Full Text Available This study proposes an optimal control law for a linear constant energy renewal multivariable system supplying power to protection and signaling circuits for switchgears and substation operations. The energy storage mechanism creates a control source that dictates the frequency of the pow er supply voltage. The entire analysis was based essentially on the use of a vector of inputs and outputs, and a matrix of operations characterizing the storage mechanism, assuming the system is both controllable and observable under arbitrary state feedback. The property of the output regulator which was desirable from the view point of feedback control design was clarified.

  1. A cost optimization model for 100% renewable residential energy supply systems

    DEFF Research Database (Denmark)

    Milan, Christian; Bojesen, Carsten; Nielsen, Mads Pagh

    2012-01-01

    for the interdependencies between the different supply technologies as well as the construction energy of the installations, consumption profiles and on-site energy resource availability. This paper aims at developing such a model for the optimal sizing of renewable energy supply systems (RES) for residential Net ZEB......'s involving on-site production of heat and electricity in combination with electricity exchanged with the public grid. The model is based on linear programming and determines the optimal capacities for each relevant supply technology in terms of the overall system costs. It has been successfully applied...

  2. Integration of a vanadium-redox-flow-battery into a hybrid renewable energy system

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, L.; Grahn, J.; Kluge, A.; Boggasch, E.; Kuehl, L. [Ostfalia Univ. of Applied Science, Wolfenbuettel (Germany). Inst. of Energy Optimized Systems EOS

    2012-07-01

    Today's renewable energy systems, like wind turbines or solar power plants, are depending on weather conditions (windy or sunny days). In order to compensate these fluctuations of energy production it is necessary to store produced energy by using one of several options which are available at this time. The planned substitution of nuclear power issues a challenge to Germany and its energy-politics. This paper deals with the efforts of Ostfalia University of Applied Sciences to alleviate a part of the most important problem of this century. Ostfalia's compares of different energy storages will give a help to develop efficient energy management strategies for hybrid systems.

  3. Proceedings of the National Renewable Energy Laboratory Wind Energy Systems Engineering Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Dykes, K.

    2014-12-01

    The second National Renewable Energy Laboratory (NREL) Wind Energy Systems Engineering Workshop was held in Broomfield, Colorado, from January 29 to February 1, 2013. The event included a day-and-a-half workshop exploring a wide variety of topics related to system modeling and design of wind turbines and plants. Following the workshop, 2 days of tutorials were held at NREL, showcasing software developed at Sandia National Laboratories, the National Aeronautics and Space Administration's Glenn Laboratories, and NREL. This document provides a brief summary of the various workshop activities and includes a review of the content and evaluation results from attendees.

  4. Differential effects on cell motility, embryonic stem cell self-renewal and senescence by diverse Src kinase family inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Tamm, Christoffer, E-mail: christoffer.tamm@imbim.uu.se; Galito, Sara Pijuan, E-mail: sara.pijuan@imbim.uu.se; Anneren, Cecilia, E-mail: cecilia.anneren@imbim.uu.se

    2012-02-15

    The Src family of non-receptor tyrosine kinases (SFKs) has been shown to play an intricate role in embryonic stem (ES) cell maintenance. In the present study we have focused on the underlying molecular mechanisms responsible for the vastly different effects induced by various commonly used SFK inhibitors. We show that several diverse cell types, including fibroblasts completely lacking SFKs, cannot undergo mitosis in response to SU6656 and that this is caused by an unselective inhibition of Aurora kinases. In contrast, PP2 and PD173952 block motility immediately upon exposure and forces cells to grow in dense colonies. The subsequent halt in proliferation of fibroblast and epithelial cells in the center of the colonies approximately 24 h post-treatment appears to be caused by cell-to-cell contact inhibition rather than a direct effect of SFK kinase inhibition. Interestingly, in addition to generating more homogenous and dense ES cell cultures, without any diverse effect on proliferation, PP2 and PD173652 also promote ES cell self-renewal by reducing the small amount of spontaneous differentiation typically observed under standard ES cell culture conditions. These effects could not be mirrored by the use of Gleevec, a potent inhibitor of c-Abl and PDGFR kinases that are also inhibited by PP2. -- Highlights: Black-Right-Pointing-Pointer SFK inhibitor SU6656 induces senescence in mouse ES cells. Black-Right-Pointing-Pointer SU6656 inhibits mitosis in a SFK-independent manner via cross-selectivity for Aurora kinases. Black-Right-Pointing-Pointer SFK inhibitor PP2 impairs cell motility in various cell lines, including mouse ES cells. Black-Right-Pointing-Pointer Ensuing impeded motility, PP2 inhibits proliferation of various cells lines except for mouse ES cells. Black-Right-Pointing-Pointer SFK inhibitors PP2 and PD173952 impede spontaneous differentiation in standard mouse ES culture maintenance.

  5. WAMS Based Intelligent Operation and Control of Modern Power System with large Scale Renewable Energy Penetration

    DEFF Research Database (Denmark)

    Rather, Zakir Hussain

    for alternative energy systems driven by the pressure to reduce carbon emission has stimulated a renewal of interest in wind power. The combined effect of growing demand and increasing level of intermittent wind energy penetration coupled with deregulated market has pushed the power system to operate close to its...... leading the system to be more vulnerable if alternative measures are not sought out. Further, Wide area measurement system (WAMS) which in contrast to traditional SCADA system is able to capture the power system dynamics, has tremendous potential applications including monitoring, control and protection...... testing and configuration of PMUs, a realistic approach for optimal PMU placement in a power system that takes real life factors into account has been proposed. The proposed method considers pragmatic approach for phase wise deployment of PMUs while accounting for coordination with other ongoing projects...

  6. Integrated renewable energy systems for off grid rural electrification of remote area

    Energy Technology Data Exchange (ETDEWEB)

    Kanase-Patil, A.B.; Saini, R.P.; Sharma, M.P. [Alternate Hydro Energy Centre, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667 (India)

    2010-06-15

    The off grid electrification by utilizing Integrated Renewable Energy System (IRES) is proposed to satisfy the electrical and cooking needs of the seven-uneletrified villages in the Almora district of Uttarakhand state, India. Four different scenarios are considered during modeling and optimization of IRES to ensure reliability parameters such as energy index ratio (EIR) and expected energy not supplied (EENS). The optimum system reliability, total system cost and cost of energy (COE) have also been worked out by introducing the customer interruption cost (CIC). The four different renewable energy scenarios have been compared for the considered study area using the LINGO software version 10. The fourth renewable energy scenario accounting 44.99% micro hydropower (MHP), 30.07% biomass, 5.19% biogas and 4.16% solar energy along with the additional resources of wind (1.27%) and energy plantation (12.33%) has been found to be the best among the different options considered. Furthermore, the optimal reliability for the fourth IRES system has been found to be 0.95 EIR at the optimized cost of Rs 19.44 lacs with estimated COE of Rs 3.36 per kWh. The COE obtained using LINGO software and HOMER software has also been compared and briefly discussed for all the four scenarios. In order to verify feasibility and cost of system for different biomass fuel prices, a sensitivity analysis has also been carried out and it has been found that the fourth scenario is more sustainable than the other considered options. (author)

  7. High-Efficiency Food Production in a Renewable Energy Based Micro-Grid Power System

    Science.gov (United States)

    Bubenheim, David; Meiners, Dennis

    2016-01-01

    Controlled Environment Agriculture (CEA) systems can be used to produce high-quality, desirable food year round, and the fresh produce can positively contribute to the health and well being of residents in communities with difficult supply logistics. While CEA has many positive outcomes for a remote community, the associated high electric demands have prohibited widespread implementation in what is typically already a fully subscribed power generation and distribution system. Recent advances in CEA technologies as well as renewable power generation, storage, and micro-grid management are increasing system efficiency and expanding the possibilities for enhancing community supporting infrastructure without increasing demands for outside supplied fuels. We will present examples of how new lighting, nutrient delivery, and energy management and control systems can enable significant increases in food production efficiency while maintaining high yields in CEA. Examples from Alaskan communities where initial incorporation of renewable power generation, energy storage and grid management techniques have already reduced diesel fuel consumption for electric generation by more than 40% and expanded grid capacity will be presented. We will discuss how renewable power generation, efficient grid management to extract maximum community service per kW, and novel energy storage approaches can expand the food production, water supply, waste treatment, sanitation and other community support services without traditional increases of consumable fuels supplied from outside the community. These capabilities offer communities with a range of choices to enhance their communities. The examples represent a synergy of technology advancement efforts to develop sustainable community support systems for future space-based human habitats and practical implementation of infrastructure components to increase efficiency and enhance health and well being in remote communities today and tomorrow.

  8. Renewable energy powered membrane technology. 1. Development and characterization of a photovoltaic hybrid membrane system.

    Science.gov (United States)

    Schäfer, A I; Broeckmann, A; Richards, B S

    2007-02-01

    In isolated communities where potable water sources as well as energy grids are limited or nonexistent, treating brackish groundwater aquifers with small-scale desalination systems can be a viable alternative to existing water infrastructures. Given the unavailability of power in many such situations, renewable energy is an obvious solution to power such systems. However, renewable energy is an intermittent power supply and with regards to the performance of intermittently operated desalination systems, only very limited experience exists, both with regards to efficiency as well as water quality. In this paper, this lack of knowledge is addressed by evaluating a system operated with varying parameters (pressure and flow) with constant power as a step toward defining a safe operating window, and they provide a basis for interpreting future data obtained with a renewable energy source. Field trials were performed on a brackish (5300 mg/L TDS; 8290 microS/cm) bore in Central Australia with a photovoltaic-powered membrane filtration (PV-membrane) system. Four nanofiltration and reverse osmosis membranes (BW30, ESPA4, NF90, TFC-S) and a number of operation parameter combinations (transmembrane pressure, feed flow, TFC-S) and operating parameters transmembrane pressure and feed flow were investigated to find the best operating conditions for maximum drinking water production and minimum specific energy consumption (SEC). The ESPA4 membrane performed best for this brackish source, producing 250 L/h of excellent drinking water (257 mg/L TDS; 400 microS/ cm) at an SEC of 1.2 kWh/m3. The issue of brine disposal or reuse is also discussed and the article compares the salinity of the produced brine with livestock water. Since the feedwater is disinfected physically using ultrafiltration (UF), the brine is free from bacteria and most viruses and hence can be seen more as a reusable product stream than a waste stream with a disposal problem.

  9. Stochastic Methods Applied to Power System Operations with Renewable Energy: A Review

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Z. [Argonne National Lab. (ANL), Argonne, IL (United States); Liu, C. [Argonne National Lab. (ANL), Argonne, IL (United States); Electric Reliability Council of Texas (ERCOT), Austin, TX (United States); Botterud, A. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-08-01

    Renewable energy resources have been rapidly integrated into power systems in many parts of the world, contributing to a cleaner and more sustainable supply of electricity. Wind and solar resources also introduce new challenges for system operations and planning in terms of economics and reliability because of their variability and uncertainty. Operational strategies based on stochastic optimization have been developed recently to address these challenges. In general terms, these stochastic strategies either embed uncertainties into the scheduling formulations (e.g., the unit commitment [UC] problem) in probabilistic forms or develop more appropriate operating reserve strategies to take advantage of advanced forecasting techniques. Other approaches to address uncertainty are also proposed, where operational feasibility is ensured within an uncertainty set of forecasting intervals. In this report, a comprehensive review is conducted to present the state of the art through Spring 2015 in the area of stochastic methods applied to power system operations with high penetration of renewable energy. Chapters 1 and 2 give a brief introduction and overview of power system and electricity market operations, as well as the impact of renewable energy and how this impact is typically considered in modeling tools. Chapter 3 reviews relevant literature on operating reserves and specifically probabilistic methods to estimate the need for system reserve requirements. Chapter 4 looks at stochastic programming formulations of the UC and economic dispatch (ED) problems, highlighting benefits reported in the literature as well as recent industry developments. Chapter 5 briefly introduces alternative formulations of UC under uncertainty, such as robust, chance-constrained, and interval programming. Finally, in Chapter 6, we conclude with the main observations from our review and important directions for future work.

  10. Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch.

    Science.gov (United States)

    López-Arribillaga, Erika; Rodilla, Verónica; Pellegrinet, Luca; Guiu, Jordi; Iglesias, Mar; Roman, Angel Carlos; Gutarra, Susana; González, Susana; Muñoz-Cánoves, Pura; Fernández-Salguero, Pedro; Radtke, Freddy; Bigas, Anna; Espinosa, Lluís

    2015-01-01

    Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic goblet cells is unknown. To address this issue, we have generated composite tamoxifen-inducible intestine-specific genetic mouse models and analyzed the expression of intestinal differentiation markers. Importantly, we found that activation of β-catenin partially rescues the differentiation phenotype of Rbpj deletion mutants, but not the loss of the ISC compartment. Moreover, we identified Bmi1, which is expressed in the ISC and progenitor compartments, as a gene that is co-regulated by Notch and β-catenin. Loss of Bmi1 resulted in reduced proliferation in the ISC compartment accompanied by p16(INK4a) and p19(ARF) (splice variants of Cdkn2a) accumulation, and increased differentiation to the post-mitotic goblet cell lineage that partially mimics Notch loss-of-function defects. Finally, we provide evidence that Bmi1 contributes to ISC self-renewal.

  11. A comparison between renewable transport fuels that can supplement or replace biofuels in a 100% renewable energy system

    DEFF Research Database (Denmark)

    Connolly, David; Mathiesen, Brian Vad; Ridjan, Iva

    2014-01-01

    Identifying renewable energy alternatives in transport is particularly complicated, since the end-user can vary from a single-person car to a cargo ship. The aim of this paper is to aid this process by comparing 7 different methods for producing transport fuels in terms of the resources required...... of energy dense fuel is also necessary. The results in this paper suggest that this fuel will be produced by hydrogenating either biomass or carbon dioxide, depending on the residual biomass available. Biomass gasification, steam electrolysis, and carbon capture are key technologies in the future......, the conversion processes used, the fuel obtained, and the transport demand met. The results indicate that electricity should be prioritised as a transport fuel in the future since it is the most efficient and cheapest pathway. However, since electricity is not suitable for all modes of transport, some form...

  12. A low cost concept for data acquisition systems applied to decentralized renewable energy plants.

    Science.gov (United States)

    Jucá, Sandro C S; Carvalho, Paulo C M; Brito, Fábio T

    2011-01-01

    The present paper describes experiences of the use of monitoring and data acquisition systems (DAS) and proposes a new concept of a low cost DAS applied to decentralized renewable energy (RE) plants with an USB interface. The use of such systems contributes to disseminate these plants, recognizing in real time local energy resources, monitoring energy conversion efficiency and sending information concerning failures. These aspects are important, mainly for developing countries, where decentralized power plants based on renewable sources are in some cases the best option for supplying electricity to rural areas. Nevertheless, the cost of commercial DAS is still a barrier for a greater dissemination of such systems in developing countries. The proposed USB based DAS presents a new dual clock operation philosophy, in which the acquisition system contains two clock sources for parallel information processing from different communication protocols. To ensure the low cost of the DAS and to promote the dissemination of this technology in developing countries, the proposed data acquisition firmware and the software for USB microcontrollers programming is a free and open source software, executable in the Linux and Windows® operating systems.

  13. A Low Cost Concept for Data Acquisition Systems Applied to Decentralized Renewable Energy Plants

    Directory of Open Access Journals (Sweden)

    Fábio T. Brito

    2011-01-01

    Full Text Available The present paper describes experiences of the use of monitoring and data acquisition systems (DAS and proposes a new concept of a low cost DAS applied to decentralized renewable energy (RE plants with an USB interface. The use of such systems contributes to disseminate these plants, recognizing in real time local energy resources, monitoring energy conversion efficiency and sending information concerning failures. These aspects are important, mainly for developing countries, where decentralized power plants based on renewable sources are in some cases the best option for supplying electricity to rural areas. Nevertheless, the cost of commercial DAS is still a barrier for a greater dissemination of such systems in developing countries. The proposed USB based DAS presents a new dual clock operation philosophy, in which the acquisition system contains two clock sources for parallel information processing from different communication protocols. To ensure the low cost of the DAS and to promote the dissemination of this technology in developing countries, the proposed data acquisition firmware and the software for USB microcontrollers programming is a free and open source software, executable in the Linux and Windows® operating systems.

  14. Downregulation of GSK3β by miR-544a to maintain self-renewal ability of lung caner stem cells.

    Science.gov (United States)

    Mo, Xiao-Mei; Li, Hua-Hui; Liu, Ming; Li, Yan-Tuan

    2014-10-01

    In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metastatic human lung cancer cells were transfected with miR-544a, and quantitative polymerase chain reaction (qPCR) was used to verify the miR-544a expression in these two cell lines. Tumor ball (spheroid) suspension culture was use to study the effects of miR-544a on lung cancer stem cells. TargetScan predicted that miR-544a interacted with GSK3β. A luciferase reporter system (F=201.37, Pcaner stem cells.

  15. EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Singh Sandeep

    2012-09-01

    Full Text Available Abstract Background Cancer stem cells are thought to be responsible for the initiation and progression of cancers. In non-small cell lung cancers (NSCLCs, Hoechst 33342 dye effluxing side population (SP cells are shown to have stem cell like properties. The oncogenic capacity of cancer stem-like cells is in part due to their ability to self-renew; however the mechanistic correlation between oncogenic pathways and self-renewal of cancer stem-like cells has remained elusive. Here we characterized the SP cells at the molecular level and evaluated its ability to generate tumors at the orthotopic site in the lung microenvironment. Further, we investigated if the self-renewal of SP cells is dependent on EGFR mediated signaling. Results SP cells were detected and isolated from multiple NSCLC cell lines (H1650, H1975, A549, as well as primary human tumor explants grown in nude mice. SP cells demonstrated stem-like properties including ability to self-renew and grow as spheres; they were able to generate primary and metastatic tumors upon orthotopic implantation into the lung of SCID mice. In vitro study revealed elevated expression of stem cell associated markers like Oct4, Sox2 and Nanog as well as demonstrated intrinsic epithelial to mesenchymal transition features in SP cells. Further, we show that abrogation of EGFR, Src and Akt signaling through pharmacological or genetic inhibitors suppresses the self-renewal growth and expansion of SP-cells and resulted in specific downregulation of Sox2 protein expression. siRNA mediated depletion of Sox2 significantly blocked the SP phenotype as well as its self-renewal capacity; whereas other transcription factors like Oct4 and Nanog played a relatively lesser role in regulating self-renewal. Interestingly, Sox2 was elevated in metastatic foci of human NSCLC samples. Conclusions Our findings suggest that Sox2 is a novel target of EGFR-Src-Akt signaling in NSCLCs that modulates self-renewal and expansion of

  16. Ex vivo assays to study self-renewal, long-term expansion, and leukemic transformation of genetically modified human hematopoietic and patient-derived leukemic stem cells.

    Science.gov (United States)

    Sontakke, Pallavi; Carretta, Marco; Capala, Marta; Schepers, Hein; Schuringa, Jan Jacob

    2014-01-01

    With the emergence of the concept of the leukemic stem cell (LSC), assays to study them remain pivotal in understanding (leukemic) stem cell biology. Although the in vivo NOD-SCID or NSG xenotransplantation model is currently still the favored assay of choice in most cases, this system has some limitations as well such as its cost-effectiveness, duration, and lack of engraftability of cells from some acute myeloid leukemia (AML) patients. Here, we describe in vitro assays in which long-term expansion and self-renewal of LSCs isolated from AML patients can be evaluated. We have optimized lentiviral transduction procedures in order to stably express genes of interest or stably downmodulate genes using RNAi in primary AML cells, and these approaches are described in detail here. Also, we describe bone marrow stromal coculture systems in which cobblestone area-forming cell activity, self-renewal, long-term expansion, and in vitro myeloid or lymphoid transformation can be evaluated in human CD34(+) cells of fetal or adult origin that are engineered to express oncogenes. Together, these tools should allow a further molecular elucidation of derailed signal transduction in LSCs.

  17. Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells.

    Science.gov (United States)

    Giraud, Julie; Failla, Laura M; Pascussi, Jean-Marc; Lagerqvist, Ebba L; Ollier, Jérémy; Finetti, Pascal; Bertucci, François; Ya, Chu; Gasmi, Imène; Bourgaux, Jean-François; Prudhomme, Michel; Mazard, Thibault; Ait-Arsa, Imade; Houhou, Leila; Birnbaum, Daniel; Pélegrin, André; Vincent, Charles; Ryall, James G; Joubert, Dominique; Pannequin, Julie; Hollande, Frédéric

    2016-06-15

    Subpopulations of cancer stem-like cells (CSC) are thought to drive tumor progression and posttreatment recurrence in multiple solid tumors. However, the mechanisms that maintain stable proportions of self-renewing CSC within heterogeneous tumors under homeostatic conditions remain poorly understood. Progastrin is a secreted peptide that exhibits tumor-forming potential in colorectal cancer, where it regulates pathways known to modulate colon CSC behaviors. In this study, we investigated the role of progastrin in regulating CSC phenotype in advanced colorectal cancer. Progastrin expression and secretion were highly enriched in colon CSC isolated from human colorectal cancer cell lines and colon tumor biopsies. Progastrin expression promoted CSC self-renewal and survival, whereas its depletion by RNA interference-mediated or antibody-mediated strategies altered the homeostatic proportions of CSC cells within heterogeneous colorectal cancer tumors. Progastrin downregulation also decreased the frequency of ALDH(high) cells, impairing their tumor-initiating potential, and inhibited the high glycolytic activity of ALDH(high) CSC to limit their self-renewal capability. Taken together, our results show how colorectal CSC maintain their tumor-initiating and self-renewal capabilities by secreting progastrin, thereby contributing to the tumor microenvironment to support malignancy. Cancer Res; 76(12); 3618-28. ©2016 AACR.

  18. Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal

    Directory of Open Access Journals (Sweden)

    Dmitri Papatsenko

    2015-08-01

    Full Text Available Analyses of gene expression in single mouse embryonic stem cells (mESCs cultured in serum and LIF revealed the presence of two distinct cell subpopulations with individual gene expression signatures. Comparisons with published data revealed that cells in the first subpopulation are phenotypically similar to cells isolated from the inner cell mass (ICM. In contrast, cells in the second subpopulation appear to be more mature. Pluripotency Gene Regulatory Network (PGRN reconstruction based on single-cell data and published data suggested antagonistic roles for Oct4 and Nanog in the maintenance of pluripotency states. Integrated analyses of published genomic binding (ChIP data strongly supported this observation. Certain target genes alternatively regulated by OCT4 and NANOG, such as Sall4 and Zscan10, feed back into the top hierarchical regulator Oct4. Analyses of such incoherent feedforward loops with feedback (iFFL-FB suggest a dynamic model for the maintenance of mESC pluripotency and self-renewal.

  19. Prediction and testing of novel transcriptional networks regulating embryonic stem cell self-renewal and commitment.

    Science.gov (United States)

    Walker, Emily; Ohishi, Minako; Davey, Ryan E; Zhang, Wen; Cassar, Paul A; Tanaka, Tetsuya S; Der, Sandy D; Morris, Quaid; Hughes, Timothy R; Zandstra, Peter W; Stanford, William L

    2007-06-07

    Stem cell fate is governed by the integration of intrinsic and extrinsic positive and negative signals upon inherent transcriptional networks. To identify novel embryonic stem cell (ESC) regulators and assemble transcriptional networks controlling ESC fate, we performed temporal expression microarray analyses of ESCs after the initiation of commitment and integrated these data with known genome-wide transcription factor binding. Effects of forced under- or overexpression of predicted novel regulators, defined as differentially expressed genes with potential binding sites for known regulators of pluripotency, demonstrated greater than 90% correspondence with predicted function, as assessed by functional and high-content assays of self-renewal. We next assembled 43 theoretical transcriptional networks in ESCs, 82% (23 out of 28 tested) of which were supported by analysis of genome-wide expression in Oct4 knockdown cells. By using this integrative approach, we have formulated novel networks describing gene repression of key developmental regulators in undifferentiated ESCs and successfully predicted the outcomes of genetic manipulation of these networks.

  20. An Innovative Use of Renewable Ground Heat for Insulation in Low Exergy Building Systems

    Directory of Open Access Journals (Sweden)

    Hansjürg Leibundgut

    2012-08-01

    Full Text Available Ground heat is a renewable resource that is readily available for buildings in cool climates, but its relatively low temperature requires the use of a heat pump to extract it for heating. We developed a system that uses low temperature ground heat directly in a building wall to reduce transmission heat losses. The Active Low Exergy Geothermal Insulation Systems (ALEGIS minimizes exergy demand and maximizes the use of renewable geothermal heat from the ground. A fluid is pumped into a small pipe network in an external layer of a wall construction that is linked to a ground heat source. This decouples the building from the outside temperature, therefore eliminating large peak demands and reducing the primary energy demand. Our steady-state analysis shows that at a design temperature of −10 °C the 6 cm thick active insulation system has equivalent performance to 11 cm of passive insulation. Our comparison of heating performance of a building with our active insulation system versus a building with static insulation of the same thickness shows a 15% reduction in annual electricity demand, and thus exergy input. We present an overview of the operation and analysis of our low exergy concept and its modeled performance.

  1. Thermoeconomic Optimization of a Renewable Polygeneration System Serving a Small Isolated Community

    Directory of Open Access Journals (Sweden)

    Francesco Calise

    2015-01-01

    Full Text Available During the last years, special attention has been paid to renewable polygeneration technologies, able of simultaneously producing thermal, cooling, electrical energy and desalinated water from seawater. This paper focuses on an innovative polygeneration system driven by renewable energy sources, including the following technologies: hybrid photovoltaic/thermal collectors, concentrating parabolic trough (CPVT, a biomass heater, a single-stage absorption chiller and a multiple-effect distillation desalination system. The system is designed to cover the base load of an isolated small community. In previous papers, the dynamic simulation model about plant operation is discussed. In this paper, a detailed exergy, economic and environmental analysis of the plant is presented. In addition, the plant was optimized using different objective functions, applying the Design of Experiment (DoE methodology which evaluates the sensitivity of the different objective functions with respect to the selected design parameters. The results show that an increase of the storage volume is generally negative, whereas increasing the solar field area involves an increase of the exergy destruction rate, but also an improvement of the CPVT exergy output provided; the final result is an increase of both the exergy efficiency and the economic profitability of the polygeneration system.

  2. Mobilisation of the potential for the renewal of energy systems in existing buildings; Mobilisierung der energetischen Erneuerungspotenziale im Wohnbaubestand

    Energy Technology Data Exchange (ETDEWEB)

    Ott, W.; Baur, M.; Kaufmann, Y. [econcept AG, Zuerich (Switzerland); Jakob, M.; Ott, A. [Centre for Energy Policy and Economics (CEPE), ETH Zuerich, Zuerich (Switzerland)

    2005-07-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) summarises the findings of an energy-policy project that looked into the potential for the renewal of energy systems in existing buildings. The report presents an analysis of the situation as far as buildings, their ownership and the development of renovation work is concerned. Also, the results of a survey made under the owners of buildings and managers of real estate with respect to building renovation aspects are presented and discussed. Further, an analysis of problems arising from deficits in the renewal of energy-relevant components is provided and background and motivation for the renewal of buildings are looked at. Also, economic aspects and sustainability issues are considered. A further chapter covers strategies and measures that can be used to mobilise the renewal potential, including legislature and labelling systems.

  3. Uniform stable observer for the disturbance estimation in two renewable energy systems.

    Science.gov (United States)

    Rubio, José de Jesús; Ochoa, Genaro; Balcazar, Ricardo; Pacheco, Jaime

    2015-09-01

    In this study, an observer for the states and disturbance estimation in two renewable energy systems is introduced. The restrictions of the gains in the proposed observer are found to guarantee its stability and the convergence of its error; furthermore, these results are utilized to obtain a good estimation. The introduced technique is applied for the states and disturbance estimation in a wind turbine and an electric vehicle. The wind turbine has a rotatory tower to catch the incoming air to be transformed in electricity and the electric vehicle has generators connected with its wheels to catch the vehicle movement to be transformed in electricity.

  4. The Economic Potential of Two Nuclear-Renewable Hybrid Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Mark Ruth, Dylan Cutler, Francisco Flores-Espino, Greg Stark, Thomas Jenkin, Travis Simpkins ...

    2016-08-01

    This report is one of a series of reports that investigate the technical and economic aspects of Nuclear-Renewable Hybrid Energy System. It provides the results of an analysis of two scenarios. The first is a Texas-syntheic gasoline scenario and the second is an Arizona-desalination scenario. The analysis focuses on the economics of the N-R HESs and how they compare to other options, including configurations without all the subsystems in each N-R HES and alternatives in which natural gas provides the energy.

  5. Net employment effects of an extension of renewable-energy systems in the Federal Republic of Germany

    Energy Technology Data Exchange (ETDEWEB)

    Ziegelmann, Arko; Mohr, Markus; Unger, Hermann [Ruhr-University Bochum, Dept. for Nuclear and New Energy Systems, Bochum (Germany)

    2000-04-01

    Renewable-energy potential exists in the Federal Republic of Germany to a great extent, but is barely used as yet. A change in the power-supply structure seems to be too risky with regard to finance and the sensitive labour market. Nevertheless, an extension of renewable energy systems in the German state North-Rhine Westphalia would lead to improved employment prospects. (Author)

  6. A DSP based power electronics interface for alternate/renewable energy systems. Quarterly report 3.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-31

    This report is an update on the research project involving the implementation of a DSP based power electronics interface for alternate/renewable energy systems that was funded by the Department of Energy under the Inventions and Innovations program 1998. The objective of this research is to develop a utility interface (dc to ac converter) suitable to interconnect alternate/renewable energy sources to the utility system. The DSP based power electronics interface in comparison with existing methods will excel in terms of efficiency, reliability and cost. Moreover DSP-based control provides the flexibility to upgrade/modify control algorithms to meet specific system requirements. The proposed interface will be capable of maintaining stiffness of the ac voltages at the point of common coupling regardless of variation in the input dc bus voltage. This will be achieved without the addition of any extra components to the basic interface topology but by inherently controlling the inverter switching strategy in accordance to the input voltage variation.

  7. Development of Nuclear Renewable Oil Shale Systems for Flexible Electricity and Reduced Fossil Fuel Emissions

    Energy Technology Data Exchange (ETDEWEB)

    Daniel Curtis; Charles Forsberg; Humberto Garcia

    2015-05-01

    We propose the development of Nuclear Renewable Oil Shale Systems (NROSS) in northern Europe, China, and the western United States to provide large supplies of flexible, dispatchable, very-low-carbon electricity and fossil fuel production with reduced CO2 emissions. NROSS are a class of large hybrid energy systems in which base-load nuclear reactors provide the primary energy used to produce shale oil from kerogen deposits and simultaneously provide flexible, dispatchable, very-low-carbon electricity to the grid. Kerogen is solid organic matter trapped in sedimentary shale, and large reserves of this resource, called oil shale, are found in northern Europe, China, and the western United States. NROSS couples electricity generation and transportation fuel production in a single operation, reduces lifecycle carbon emissions from the fuel produced, improves revenue for the nuclear plant, and enables a major shift toward a very-low-carbon electricity grid. NROSS will require a significant development effort in the United States, where kerogen resources have never been developed on a large scale. In Europe, however, nuclear plants have been used for process heat delivery (district heating), and kerogen use is familiar in certain countries. Europe, China, and the United States all have the opportunity to use large scale NROSS development to enable major growth in renewable generation and either substantially reduce or eliminate their dependence on foreign fossil fuel supplies, accelerating their transitions to cleaner, more efficient, and more reliable energy systems.

  8. Genetic Activation of Hedgehog Signaling Unbalances the Rate of Neural Stem Cell Renewal by Increasing Symmetric Divisions

    Directory of Open Access Journals (Sweden)

    Julien Ferent

    2014-08-01

    Full Text Available In the adult brain, self-renewal is essential for the persistence of neural stem cells (NSCs throughout life, but its regulation is still poorly understood. One NSC can give birth to two NSCs or one NSC and one transient progenitor. A correct balance is necessary for the maintenance of germinal areas, and understanding the molecular mechanisms underlying NSC division mode is clearly important. Here, we report a function of the Sonic Hedgehog (SHH receptor Patched in the direct control of long-term NSC self-renewal in the subependymal zone. We show that genetic conditional activation of SHH signaling in adult NSCs leads to their expansion and the depletion of their direct progeny. These phenotypes are associated in vitro with an increase in NSC symmetric division in a process involving NOTCH signaling. Together, our results demonstrate a tight control of adult neurogenesis and NSC renewal driven by Patched.

  9. Renewable Energy and Hydrogen System Concepts for Remote Communities in the West Nordic Region

    Energy Technology Data Exchange (ETDEWEB)

    Ulleberg, Oeystein; Moerkved, Andreas

    2008-02-25

    In 2003 the Nordic Council of Ministers granted the funding for the first of several studies on renewable energy and hydrogen (RE/H2) energy systems for remote communities in the West Nordic region. The objective with this report is to summarize the main findings from Phase II and III of the West Nordic project. The island Nolsoy, Faroe Islands, was selected as a case study. The main conclusion is that it makes sense to design a wind/diesel-system with thermal storage, both from a techno-economical and environmental point of view. Such systems can have close to 100% local utilization of the wind energy, and can cover up to 75% of the total annual electricity demand and 35% of the annual heat demand at a cost of energy around 0.07 - 0.09 euro/kWh. The introduction of a hydrogen system is technically feasible, but doubles the overall investment costs

  10. OPTIMAL DYNAMICAL BALANCE HARVESTING FOR A CLASS OF RENEWABLE RESOURCES SYSTEM

    Institute of Scientific and Technical Information of China (English)

    何泽荣; 王绵森; 王峰

    2004-01-01

    An optimal utilization problem for a class of renewable resources system is investigated. Firstly, a control problem was proposed by introducing a new utility function which depends on the harvesting effort and the stock of resources.Secondly, the existence of optimal solution for the problem was discussed. Then, using a maximum principle for infinite horizon problem, a nonlinear four-dimensional differential equations system was attained. After a detailed analysis of the unique positive equilibrium solution, the existence of limit cycles for the system is demonstrated. Next a reduced system on the central manifold is carefully derived, which assures the stability of limit cycles. Finally significance of the results in bioeconomics is explained.

  11. Choosing The Right Technology - Optimized Design Of Renewable Supply Systems For Residential Houses

    DEFF Research Database (Denmark)

    Milan, Christian; Bojesen, Carsten; Nielsen, Mads Pagh

    2012-01-01

    The use of renewable energy sources (RES) has continuously increased throughout the last decade. In the residential building sector the trend goes towards energy supply systems based on multiple RES. This is mainly due to political requirements, governmental subsidies and fuel price development....... These systems not only require an optimal design with respect to the installed capacities but also the right choice in combining the available technologies assuring a cost-effective solution. The aim of this paper is to present an optimization methodology for residential on-site energy supply systems based...... costs including system installation and operating expenses. The approach is applied to a case study of a residential single family house under Danish conditions. It delivers rapidly site-specific solutions and can easily be used as an extension for common building energy simulation software. In the case...

  12. Stochastic simulation of power systems with integrated renewable and utility-scale storage resources

    Science.gov (United States)

    Degeilh, Yannick

    The push for a more sustainable electric supply has led various countries to adopt policies advocating the integration of renewable yet variable energy resources, such as wind and solar, into the grid. The challenges of integrating such time-varying, intermittent resources has in turn sparked a growing interest in the implementation of utility-scale energy storage resources ( ESRs), with MWweek storage capability. Indeed, storage devices provide flexibility to facilitate the management of power system operations in the presence of uncertain, highly time-varying and intermittent renewable resources. The ability to exploit the potential synergies between renewable and ESRs hinges on developing appropriate models, methodologies, tools and policy initiatives. We report on the development of a comprehensive simulation methodology that provides the capability to quantify the impacts of integrated renewable and ESRs on the economics, reliability and emission variable effects of power systems operating in a market environment. We model the uncertainty in the demands, the available capacity of conventional generation resources and the time-varying, intermittent renewable resources, with their temporal and spatial correlations, as discrete-time random processes. We deploy models of the ESRs to emulate their scheduling and operations in the transmission-constrained hourly day-ahead markets. To this end, we formulate a scheduling optimization problem (SOP) whose solutions determine the operational schedule of the controllable ESRs in coordination with the demands and the conventional/renewable resources. As such, the SOP serves the dual purpose of emulating the clearing of the transmission-constrained day-ahead markets (DAMs ) and scheduling the energy storage resource operations. We also represent the need for system operators to impose stricter ramping requirements on the conventional generating units so as to maintain the system capability to perform "load following'', i

  13. Hydrogels as feeder-free scaffolds for long-term self-renewal of mouse induced pluripotent stem (mips) cells.

    OpenAIRE

    2012-01-01

    Expanding undifferentiated induced pluripotent stem (iPS) cells in vitro is a basic requirement for application of iPS cells in both fundamental research and clinical regeneration. In this study, we intended to establish a simple, low cost and efficient method for the long-term self-renewal of mouse induced pluripotent stem (miPS) cells without using feeder-cells and adhesive proteins. Three scaffolds were selected for the long-term subculture of miPS cells over two months starting from passa...

  14. T-cell suicide gene therapy prompts thymic renewal in adults after hematopoietic stem cell transplantation.

    Science.gov (United States)

    Vago, Luca; Oliveira, Giacomo; Bondanza, Attilio; Noviello, Maddalena; Soldati, Corrado; Ghio, Domenico; Brigida, Immacolata; Greco, Raffaella; Lupo Stanghellini, Maria Teresa; Peccatori, Jacopo; Fracchia, Sergio; Del Fiacco, Matteo; Traversari, Catia; Aiuti, Alessandro; Del Maschio, Alessandro; Bordignon, Claudio; Ciceri, Fabio; Bonini, Chiara

    2012-08-30

    The genetic modification of T cells with a suicide gene grants a mechanism of control of adverse reactions, allowing safe infusion after partially incompatible hematopoietic stem cell transplantation (HSCT). In the TK007 clinical trial, 22 adults with hematologic malignancies experienced a rapid and sustained immune recovery after T cell-depleted HSCT and serial infusions of purified donor T cells expressing the HSV thymidine kinase suicide gene (TK+ cells). After a first wave of circulating TK+ cells, the majority of T cells supporting long-term immune reconstitution did not carry the suicide gene and displayed high numbers of naive lymphocytes, suggesting the thymus-dependent development of T cells, occurring only upon TK+ -cell engraftment. Accordingly, after the infusions, we documented an increase in circulating TCR excision circles and CD31+ recent thymic emigrants and a substantial expansion of the active thymic tissue as shown by chest tomography scans. Interestingly, a peak in the serum level of IL-7 was observed after each infusion of TK+ cells, anticipating the appearance of newly generated T cells. The results of the present study show that the infusion of genetically modified donor T cells after HSCT can drive the recovery of thymic activity in adults, leading to immune reconstitution.

  15. Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult Thymus

    Directory of Open Access Journals (Sweden)

    Kahlia Wong

    2014-08-01

    Full Text Available Thymic epithelial cells (TECs are critical for T cell development and self-tolerance but are gradually lost with age. The existence of thymic epithelial progenitors (TEPCs in the postnatal thymus has been inferred, but their identity has remained enigmatic. Here, we assessed the entire adult TEC compartment in order to reveal progenitor capacity is retained exclusively within a subset of immature thymic epithelium displaying several hallmark features of stem/progenitor function. These adult TEPCs generate mature cortical and medullary lineages in a stepwise fashion, including Aire+ TEC, within fetal thymus reaggregate grafts. Although relatively quiescent in vivo, adult TEPCs demonstrate significant in vitro colony formation and self-renewal. Importantly, 3D-cultured TEPCs retain their capacity to differentiate into cortical and medullary TEC lineages when returned to an in vivo thymic microenvironment. No other postnatal TEC subset exhibits this combination of properties. The characterization of adult TEPC will enable progress in understanding TEC biology in aging and regeneration.

  16. Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells.

    Directory of Open Access Journals (Sweden)

    Catherine E Forristal

    Full Text Available Energy metabolism is intrinsic to cell viability but surprisingly has been little studied in human embryonic stem cells (hESCs. The current study aims to investigate the effect of environmental O2 tension on carbohydrate utilisation of hESCs. Highly pluripotent hESCs cultured at 5% O2 consumed significantly more glucose, less pyruvate and produced more lactate compared to those maintained at 20% O2. Moreover, hESCs cultured at atmospheric O2 levels expressed significantly less OCT4, SOX2 and NANOG than those maintained at 5% O2. To determine whether this difference in metabolism was a reflection of the pluripotent state, hESCs were cultured at 5% O2 in the absence of FGF2 for 16 hours leading to a significant reduction in the expression of SOX2. In addition, these cells consumed less glucose and produced significantly less lactate compared to those cultured in the presence of FGF2. hESCs maintained at 5% O2 were found to consume significantly less O2 than those cultured in the absence of FGF2, or at 20% O2. GLUT1 expression correlated with glucose consumption and using siRNA and chromatin immunoprecipitation was found to be directly regulated by hypoxia inducible factor (HIF-2α at 5% O2. In conclusion, highly pluripotent cells associated with hypoxic culture consume low levels of O2, high levels of glucose and produce large amounts of lactate, while at atmospheric conditions glucose consumption and lactate production are reduced and there is an increase in oxidative metabolism. These data suggest that environmental O2 regulates energy metabolism and is intrinsic to the self-renewal of hESCs.

  17. The early postnatal nonhuman primate neocortex contains self-renewing multipotent neural progenitor cells.

    Directory of Open Access Journals (Sweden)

    Jihane Homman-Ludiye

    Full Text Available The postnatal neocortex has traditionally been considered a non-neurogenic region, under non-pathological conditions. A few studies suggest, however, that a small subpopulation of neural cells born during postnatal life can differentiate into neurons that take up residence within the neocortex, implying that postnatal neurogenesis could occur in this region, albeit at a low level. Evidence to support this hypothesis remains controversial while the source of putative neural progenitors responsible for generating new neurons in the postnatal neocortex is unknown. Here we report the identification of self-renewing multipotent neural progenitor cells (NPCs derived from the postnatal day 14 (PD14 marmoset monkey primary visual cortex (V1, striate cortex. While neuronal maturation within V1 is well advanced by PD14, we observed cells throughout this region that co-expressed Sox2 and Ki67, defining a population of resident proliferating progenitor cells. When cultured at low density in the presence of epidermal growth factor (EGF and/or fibroblast growth factor 2 (FGF-2, dissociated V1 tissue gave rise to multipotent neurospheres that exhibited the ability to differentiate into neurons, oligodendrocytes and astrocytes. While the capacity to generate neurones and oligodendrocytes was not observed beyond the third passage, astrocyte-restricted neurospheres could be maintained for up to 6 passages. This study provides the first direct evidence for the existence of multipotent NPCs within the postnatal neocortex of the nonhuman primate. The potential contribution of neocortical NPCs to neural repair following injury raises exciting new possibilities for the field of regenerative medicine.

  18. The early postnatal nonhuman primate neocortex contains self-renewing multipotent neural progenitor cells.

    Science.gov (United States)

    Homman-Ludiye, Jihane; Merson, Tobias D; Bourne, James A

    2012-01-01

    The postnatal neocortex has traditionally been considered a non-neurogenic region, under non-pathological conditions. A few studies suggest, however, that a small subpopulation of neural cells born during postnatal life can differentiate into neurons that take up residence within the neocortex, implying that postnatal neurogenesis could occur in this region, albeit at a low level. Evidence to support this hypothesis remains controversial while the source of putative neural progenitors responsible for generating new neurons in the postnatal neocortex is unknown. Here we report the identification of self-renewing multipotent neural progenitor cells (NPCs) derived from the postnatal day 14 (PD14) marmoset monkey primary visual cortex (V1, striate cortex). While neuronal maturation within V1 is well advanced by PD14, we observed cells throughout this region that co-expressed Sox2 and Ki67, defining a population of resident proliferating progenitor cells. When cultured at low density in the presence of epidermal growth factor (EGF) and/or fibroblast growth factor 2 (FGF-2), dissociated V1 tissue gave rise to multipotent neurospheres that exhibited the ability to differentiate into neurons, oligodendrocytes and astrocytes. While the capacity to generate neurones and oligodendrocytes was not observed beyond the third passage, astrocyte-restricted neurospheres could be maintained for up to 6 passages. This study provides the first direct evidence for the existence of multipotent NPCs within the postnatal neocortex of the nonhuman primate. The potential contribution of neocortical NPCs to neural repair following injury raises exciting new possibilities for the field of regenerative medicine.

  19. PROFIT MAXIMIZATION AND OPTIMAL SIZING OF RENEWABLE ENERGY SOURCES IN A HYBRID SYSTEM

    Directory of Open Access Journals (Sweden)

    YAJVENDER PAL VERMA

    2010-09-01

    Full Text Available The renewable energy sources wind, solar etc. have become very essential and important in the generation mix as a result of rising energy demand and environmental reasons. In addition tax is being imposed on high carbon emission. But the uncertainty and variability associated with renewable such as wind may result in economical andtechnical problems in the power system. In order to compensate wind intermittency, generation resources such as gas plant, pumped storage unit etc. are employed due to their lesser start up time, lower operating cost and good ramping capabilities. This paper proposes a model which investigates the combined operation of thermal, wind andpumped storage units for the profit maximization in varying wind, load, and price scenarios. The optimal size of the pumped storage unit to be used has been obtained after putting the system to different operating conditions such as varying wind power and load demand, imposing tax on carbon emission and varying ramping limits etc. The model has been applied on IEEE-30 bus test data and satisfactory results have been obtained for optimal hybrid systemoperation.

  20. The Economic Potential of Two Nuclear-Renewable Hybrid Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Mark [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cutler, Dylan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Flores-Espino, Francisco [National Renewable Energy Lab. (NREL), Golden, CO (United States); Stark, Greg [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jenkin, Thomas [National Renewable Energy Lab. (NREL), Golden, CO (United States); Simpkins, Travis [National Renewable Energy Lab. (NREL), Golden, CO (United States); Macknick, Jordan [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-08-01

    Tightly coupled nuclear-renewable hybrid energy systems (N-R HESs) are an option that can generate zero-carbon, dispatchable electricity and provide zero-carbon energy for industrial processes at a lower cost than alternatives. N-R HESs are defined as systems that are managed by a single entity and link a nuclear reactor that generates heat, a thermal power cycle for heat to electricity conversion, at least one renewable energy source, and an industrial process that uses thermal and/or electrical energy. This report provides results of an analysis of two N-R HES scenarios. The first is a Texas-synthetic gasoline scenario that includes four subsystems: a nuclear reactor, thermal power cycle, wind power plant, and synthetic gasoline production technology. The second is an Arizona-desalination scenario with its four subsystems a nuclear reactor, thermal power cycle, solar photovoltaics, and a desalination plant. The analysis focuses on the economics of the N-R HESs and how they compare to other options, including configurations without all the subsystems in each N-R HES and alternatives where the energy is provided by natural gas.

  1. TOWARDS A RESILIENT ENERGY SYSTEM IN EASTERN ROMANIA – FROM FOSSIL FUELS TO RENEWABLE SOURCES

    Directory of Open Access Journals (Sweden)

    BĂNICĂ Alexandru

    2015-12-01

    Full Text Available The study takes into account the two Romanian Eastern regions (North East and South East trying to emphasize the post-communist dynamics of the energy sector in order to draw a general perspective for the future evolution towards both energy security and a clean environment. Before 1989, the energy sector, that had to sustain not only the population needs, but also an oversized manufacturing industry, was based on big power plants usually using coal and oil and highly polluting the environment. The hydropower had a rather small share in the total energy production. This inherited system was very much resistant after the end of the centralized political system, therefore after the general industrial decline the energy sector remained the main source of air pollution in many towns and cities from Romania. Meanwhile, in the last 6-7 years, due to a favourable national political context, we assisted, especially in the analysed area, to an important emergence of renewable energy investments (mainly wind and solar energy, but also biomass or hydro-energy. Our purpose is to evaluate, from a geographical point of view, the extent and the implications of a desirable progressive shift from fossil fuels to renewable energy that could radically change the territorial relations and sustain development on the long term.

  2. Distributed Renewable Generation and Storage System Sizing Based on Smart Dispatch of Microgrids

    Directory of Open Access Journals (Sweden)

    Raji Atia

    2016-03-01

    Full Text Available This paper considers the contribution of independent owners (IOs operating within microgrids (MGs toward green power generation in deregulated energy markets. An optimization scheme is introduced for sizing distributed renewable generation (DRG and a distributed energy storage system (DESS based on a novel energy management system (EMS that accounts for demand response (DR, DESS dispatch and performance degradation, dynamic pricing environments, power distribution loss and irregular renewable generation. The proposed EMS utilizes an iterative Newton-Raphson linear programming algorithm that schedules resources in order to minimize the objective function, to deal with the complicated nonlinear nature of the problem and to enable efficient long-term assessments. The EMS is used to evaluate candidate solutions that are generated by a genetic algorithm (GA to determine the optimal combination of DRG and DESS. A case study for IEEE 34-bus distribution MG in Okinawa, Japan, is used for testing the algorithm and analyzing the potential for IO/MG investments and their strategies.

  3. DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions.

    Science.gov (United States)

    Insinga, Alessandra; Cicalese, Angelo; Faretta, Mario; Gallo, Barbara; Albano, Luisa; Ronzoni, Simona; Furia, Laura; Viale, Andrea; Pelicci, Pier Giuseppe

    2013-03-01

    DNA damage leads to a halt in proliferation owing to apoptosis or senescence, which prevents transmission of DNA alterations. This cellular response depends on the tumor suppressor p53 and functions as a powerful barrier to tumor development. Adult stem cells are resistant to DNA damage-induced apoptosis or senescence, however, and how they execute this response and suppress tumorigenesis is unknown. We show that irradiation of hematopoietic and mammary stem cells up-regulates the cell cycle inhibitor p21, a known target of p53, which prevents p53 activation and inhibits p53 basal activity, impeding apoptosis and leading to cell cycle entry and symmetric self-renewing divisions. p21 also activates DNA repair, limiting DNA damage accumulation and self-renewal exhaustion. Stem cells with moderate DNA damage and diminished self-renewal persist after irradiation, however. These findings suggest that stem cells have evolved a unique, p21-dependent response to DNA damage that leads to their immediate expansion and limits their long-term survival.

  4. Introduction of renewable energy sources in the district heating system of Greece

    Directory of Open Access Journals (Sweden)

    Nikolaos Margaritis

    2016-06-01

    Full Text Available The district heating (DH system of Greece, mainly supported from lignite fired stations, is facing lately significant challenges. Stricter emission limits, decreased efficiency due to old age and increased costs are major challenges of the lignite sector and are expected to result in the decommissioning of several lignite-fired units in the coming years. As a result, managers of DH networks are currently investigating alternative scenarios for the substitution of thermal power that it is expected to be lost, through the integration of Renewable Energy Sources (RES into the system. In this paper, the DH systems of Kozani and Ptolemaida are examined regarding possible introduction of RES. The first study examines district heating of Kozani and alternative future options for covering a part of city’s thermal load whereas the second study refers to a biomass CHP plant (ORC technology, 1MWe, 5MWth to be powered from a biomass mixture (wood chips and straw.

  5. Control strategy for a distributed DC power system with renewable energy

    Energy Technology Data Exchange (ETDEWEB)

    Kurohane, Kyohei; Uehara, Akie; Senjyu, Tomonobu; Yona, Atsushi; Urasaki, Naomitsu [University of the Ryukyus, 1 Senbaru, Nishihara-cho, Nakagami, Okinawa 903-0213 (Japan); Funabashi, Toshihisa [Meidensha Corporation, 36-2 Nihonbashi-Hakozakicho, Chuo-ku, Tokyo 103-8513 (Japan); Kim, Chul-Hwan [Sungkyunkwan University and NPT Center, Suwon City 440-746 (Korea)

    2011-01-15

    This paper deals with a DC-micro-grid with renewable energy. The proposed method is composed of a gearless wind power generation system, a battery, and DC loads in a DC distribution system. The battery helps to avoid the DC over-voltages by absorbing the power of the permanent magnet synchronous generator (PMSG) during line-fault. In addition, the control schemes presented in this paper including the maximum power point tracking (MPPT) control and a pitch angle control for the gearless wind turbine generator. By means of the proposed method, high-reliable power can be supplied to the DC distribution system during the line-fault and stable power supply from the PMSG can be achieved after line-fault clearing. The effectiveness of the proposed method is examined in a MATLAB/Simulink {sup registered} environment. (author)

  6. Smart Energy Storages for Integration of Renewables in 100% Independent Energy Systems

    DEFF Research Database (Denmark)

    Krajačić, Goran; Duić, Neven; Mathiesen, Brian Vad

    2010-01-01

    Primary energy import dependence of the European Union is currently around 53%, and it is expected that in the next 20-30 years it will reach or surpass 70%. The situation in Croatia is similar. In 2007 import dependence was 53.1%, while for 2030 it is predicted to reach 72%. Such import dependence...... for energy storage, in the primary or secondary form, in order to transfer energy surplus form period of excess to the period when there is a lack. The problem of storage systems is that they increase the cost of already expensive distributed and renewable energy sources, making them, in market circumstances......, even less economically viable. Although there are a number of storage technologies, as chemical, potential or heat energy, not all those technologies are optimal for each energy system. The paper shows results of energy planning and several cases where use of smart energy storage system could help...

  7. Hybrid renewable energy system using doubly-fed induction generator and multilevel inverter

    Science.gov (United States)

    Ahmed, Eshita

    The proposed hybrid system generates AC power by combining solar and wind energy converted by a doubly-fed induction generator (DFIG). The DFIG, driven by a wind turbine, needs rotor excitation so the stator can supply a load or the grid. In a variable-speed wind energy system, the stator voltage and its frequency vary with wind speed, and in order to keep them constant, variable-voltage and variable-frequency rotor excitation is to be provided. A power conversion unit supplies the rotor, drawing power either from AC mains or from a PV panel depending on their availability. It consists of a multilevel inverter which gives lower harmonic distortion in the stator voltage. Maximum power point tracking techniques have been implemented for both wind and solar power. The complete hybrid renewable energy system is implemented in a PSIM-Simulink interface and the wind energy conversion portion is realized in hardware using dSPACE controller board.

  8. A global renewable energy system: A modelling exercise in ETSAP/TIAM

    DEFF Research Database (Denmark)

    Føyn, Tullik Helene Ystanes; Karlsson, Kenneth Bernard; Balyk, Olexandr;

    2011-01-01

    . Results from the modelling are global and regional energy consumption, emission of greenhouse gasses and thereby potential increase in global mean temperature. Furthermore, total system costs are compared to a reference scenario. Existing analysis with TIAM shows different ways of reaching the 2 °C target......This paper aims to test the ETSAP2-TIAM global energy system model and to try out how far it can go towards a global 100% renewable energy system with the existing model database. This will show where limits in global resources are met and where limits in the data fed to the model until now are met...... (increase in global mean temperature) and also how uncertainty on different factors influences the optimal solution. The main conclusion from existing analysis with TIAM is that the 2 °C target is possible to reach, but it will be expensive. Another very important point is that if uncertainty on the value...

  9. Modeling and Simulation of Renewable Hybrid Power System using Matlab Simulink Environment

    Directory of Open Access Journals (Sweden)

    Cristian Dragoş Dumitru

    2010-12-01

    Full Text Available The paper presents the modeling of a solar-wind-hydroelectric hybrid system in Matlab/Simulink environment. The application is useful for analysis and simulation of a real hybrid solar-wind-hydroelectric system connected to a public grid. Application is built on modular architecture to facilitate easy study of each component module influence. Blocks like wind model, solar model, hydroelectric model, energy conversion and load are implemented and the results of simulation are also presented. As an example, one of the most important studies is the behavior of hybrid system which allows employing renewable and variable in time energy sources while providing a continuous supply. Application represents a useful tool in research activity and also in teaching

  10. Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells.

    Science.gov (United States)

    Zhao, Rui; Fallon, Timothy R; Saladi, Srinivas Vinod; Pardo-Saganta, Ana; Villoria, Jorge; Mou, Hongmei; Vinarsky, Vladimir; Gonzalez-Celeiro, Meryem; Nunna, Naveen; Hariri, Lida P; Camargo, Fernando; Ellisen, Leif W; Rajagopal, Jayaraj

    2014-07-28

    Our understanding of how stem cells are regulated to maintain appropriate tissue size and architecture is incomplete. We show that Yap (Yes-associated protein 1) is required for the actual maintenance of an adult mammalian stem cell. Without Yap, adult airway basal stem cells are lost through their unrestrained differentiation, resulting in the simplification of a pseudostratified epithelium into a columnar one. Conversely, Yap overexpression increases stem cell self-renewal and blocks terminal differentiation, resulting in epithelial hyperplasia and stratification. Yap overexpression in differentiated secretory cells causes them to partially reprogram and adopt a stem cell-like identity. In contrast, Yap knockdown prevents the dedifferentiation of secretory cells into stem cells. We then show that Yap functionally interacts with p63, the cardinal transcription factor associated with myriad epithelial basal stem cells. In aggregate, we show that Yap regulates all of the cardinal behaviors of airway epithelial stem cells and determines epithelial architecture.

  11. Hydro Solar 21- A building energetic demand providing system based on renewable energies and hydrogen; Hydro Solar 21- Energias renovables e hidrogeno para el abastecimiento energetico de un edificio

    Energy Technology Data Exchange (ETDEWEB)

    Renilla Collado, R.; Ortega Izquierdo, M.

    2008-07-01

    Hydro Solar 21 is an energy innovation Project carried out in Burgos City to develop an energy production system based on renewable energies to satisfy light and air condition requirements of a restored building. Nocturnal light demand is satisfied with hydrogen consumption in fuel cells. This hydrogen is produced with an energy renewable system made up of two wind turbine generators and a photovoltaic system. The air conditioning demand is satisfied with an adsorption solar system which produces cold water using thermal solar energy. (Author) 8 refs.

  12. Dynamic modeling of hybrid renewable energy systems for off-grid applications

    Science.gov (United States)

    Hasemeyer, Mark David

    The volatile prices of fossil fuels and their contribution to global warming have caused many people to turn to renewable energy systems. Many developing communities are forced to use these systems as they are too far from electrical distribution. As a result, numerous software models have been developed to simulate hybrid renewable energy systems. However almost, if not all, implementations are static in design. A static design limits the ability of the model to account for changes over time. Dynamic modeling can be used to fill the gaps where other modeling techniques fall short. This modeling practice allows the user to account for the effects of technological and economic factors over time. These factors can include changes in energy demand, energy production, and income level. Dynamic modeling can be particularly useful for developing communities who are off-grid and developing at rapid rates. In this study, a dynamic model was used to evaluate a real world system. A non-governmental organization interested in improving their current infrastructure was selected. Five different scenarios were analyzed and compared in order to discover which factors the model is most sensitive to. In four of the scenarios, a new energy system was purchased in order to account for the opening of a restaurant that would be used as a source of local income generation. These scenarios were then compared to a base case in which a new system was not purchased, and the restaurant was not opened. Finally, the results were used to determine which variables had the greatest impact on the various outputs of the simulation.

  13. Smart nanogrid systems for disaster mitigation employing deployable renewable energy harvesting devices

    Science.gov (United States)

    Ghasemi-Nejhad, Mehrdad N.; Menendez, Michael; Minei, Brenden; Wong, Kyle; Gabrick, Caton; Thornton, Matsu; Ghorbani, Reza

    2016-04-01

    This paper explains the development of smart nanogrid systems for disaster mitigation employing deployable renewable energy harvesting, or Deployable Disaster Devices (D3), where wind turbines and solar panels are developed in modular forms, which can be tied together depending on the needed power. The D3 packages/units can be used: (1) as a standalone unit in case of a disaster where no source of power is available, (2) for a remote location such as a farm, camp site, or desert (3) for a community that converts energy usage from fossil fuels to Renewable Energy (RE) sources, or (4) in a community system as a source of renewable energy for grid-tie or off-grid operation. In Smart D3 system, the power is generated (1) for consumer energy needs, (2) charge storage devices (such as batteries, capacitors, etc.), (3) to deliver power to the network when the smart D3 nano-grid is tied to the network and when the power generation is larger than consumption and storage recharge needs, or (4) to draw power from the network when the smart D3 nano-grid is tied to the network and when the power generation is less than consumption and storage recharge needs. The power generated by the Smart D3 systems are routed through high efficiency inverters for proper DC to DC or DC to AC for final use or grid-tie operations. The power delivery from the D3 is 220v AC, 110v AC and 12v DC provide proper power for most electrical and electronic devices worldwide. The power supply is scalable, using a modular system that connects multiple units together. This are facilitated through devices such as external Input-Output or I/O ports. The size of the system can be scaled depending on how many accessory units are connected to the I/O ports on the primary unit. The primary unit is the brain of the system allowing for smart switching and load balancing of power input and smart regulation of power output. The Smart D3 systems are protected by ruggedized weather proof casings allowing for operation

  14. The Cost-Optimal Distribution of Wind and Solar Generation Facilities in a Simplified Highly Renewable European Power System

    Science.gov (United States)

    Kies, Alexander; von Bremen, Lüder; Schyska, Bruno; Chattopadhyay, Kabitri; Lorenz, Elke; Heinemann, Detlev

    2016-04-01

    The transition of the European power system from fossil generation towards renewable sources is driven by different reasons like decarbonisation and sustainability. Renewable power sources like wind and solar have, due to their weather dependency, fluctuating feed-in profiles, which make their system integration a difficult task. To overcome this issue, several solutions have been investigated in the past like the optimal mix of wind and PV [1], the extension of the transmission grid or storages [2]. In this work, the optimal distribution of wind turbines and solar modules in Europe is investigated. For this purpose, feed-in data with an hourly temporal resolution and a spatial resolution of 7 km covering Europe for the renewable sources wind, photovoltaics and hydro was used. Together with historical load data and a transmission model , a simplified pan-European power power system was simulated. Under cost assumptions of [3] the levelized cost of electricity (LCOE) for this simplified system consisting of generation, consumption, transmission and backup units is calculated. With respect to the LCOE, the optimal distribution of generation facilities in Europe is derived. It is shown, that by optimal placement of renewable generation facilities the LCOE can be reduced by more than 10% compared to a meta study scenario [4] and a self-sufficient scenario (every country produces on average as much from renewable sources as it consumes). This is mainly caused by a shift of generation facilities towards highly suitable locations, reduced backup and increased transmission need. The results of the optimization will be shown and implications for the extension of renewable shares in the European power mix will be discussed. The work is part of the RESTORE 2050 project (Wuppertal Institute, Next Energy, University of Oldenburg), that is financed by the Federal Ministry of Education and Research (BMBF, Fkz. 03SFF0439A). [1] Kies, A. et al.: Kies, Alexander, et al

  15. Responses of Cell Renewal Systems to Long-term Low-Level Radiation Exposure: A Feasibility Study Applying Advanced Molecular Biology Techniques on Available Histological and Cytological Material of Exposed Animals and Men

    Energy Technology Data Exchange (ETDEWEB)

    Fliedner Theodor M.; Feinendegen Ludwig E.; Meineke Viktor; Fritz Thomas E.

    2005-02-28

    First results of this feasibility study showed that evaluation of the stored material of the chronically irradiated dogs with modern molecular biological techniques proved to be successful and extremely promising. Therefore an in deep analysis of at least part of the huge amount of remaining material is of outmost interest. The methods applied in this feasibility study were pathological evaluation with different staining methods, protein analysis by means of immunohistochemistry, strand break analysis with the TdT-assay, DNA- and RNA-analysis as well as genomic examination by gene array. Overall more than 50% of the investigated material could be used. In particular the results of an increased stimulation of the immune system within the dogs of the 3mSv group as both compared to the control and higher dose groups gives implications for the in depth study of the cellular events occurring in context with low dose radiation. Based on the findings of this study a further evaluation and statistically analysis of more material can help to identify promising biomarkers for low dose radiation. A systematic evaluation of a correlation of dose rates and strand breaks within the dog tissue might moreover help to explain mechanisms of tolerance to IR. One central problem is that most sequences for dog specific primers are not known yet. The discovery of the dog genome is still under progress. In this study the isolation of RNA within the dog tissue was successful. But up to now there are no gene arrays or gene chips commercially available, tested and adapted for canine tissue. The uncritical use of untested genomic test systems for canine tissue seems to be ineffective at the moment, time consuming and ineffective. Next steps in the investigation of genomic changes after IR within the stored dog tissue should be limited to quantitative RT-PCR of tested primer sequences for the dog. A collaboration with institutions working in the field of the discovery of the dog genome could

  16. Simulation of long term renewable energy feed-in for European power system studies

    Science.gov (United States)

    Kies, Alexander; Nag, Kabitri; von Bremen, Lueder; Lorenz, Elke; Heinemann, Detlev; Späth, Stephan

    2014-05-01

    Renewable energies already play a remarkable role in Europe as of today. It is expected that wind and solar amongst other renewables will contribute strongly to the future European energy generation. However, wind and solar generation facilities have due to the weather dependent nature of their resources highly fluctuating feed-in profiles. To overcome the mismatch between energy demand and generation it is important to study and understand the generation patterns and balancing potentials. The goal of the current work is to investigate how the feed-in time series from different renewable sources like on- and offshore wind, photovoltaic, solar thermal, wave, hydro, geothermal and biomass power and combination of them look like in an European power supply system . The work is part of the RESTORE 2050 project (BMU) that investigates the requirements for cross-country grid extensions, usage of storage technologies and capacities, the development of new balancing technologies and the conceptual design of the future energy market which is suitable for high generation percentages of solar and wind. High temporally and spatially resolved long term weather data from COSMO-EU, MERRA and Meteosat (MFG/MSG) satellite data has been used to simulate feed-in from several types of renewable energy sources on a 7 x 7 km grid covering Europe. For wind speeds MERRA reanalysis data has been statistically downscaled to account for orography. Generation was aggregated on the country level and production patterns and their variations in time of different resources were investigated for the years ranging from 2002 to 2012. In a first step the quality of the simulated feed in time series has been investigated by comparison to real observations of wind power and PV generation. Furthermore, some sensitivity studies with respect to underlying assumptions like spatial distribution of wind and PV capacities, the chosen hub-height and wind power curve have been done and will be presented. While

  17. Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities

    Science.gov (United States)

    Parasramka, Mansi A.

    2016-01-01

    Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA that are mechanistically linked to cancer stem cell self-renewal and differentiation, or aberrant signaling pathways associated with tumor growth or progression, offer new opportunities for therapeutic intervention. PMID:27358893

  18. miR-544 Regulates Dairy Goat Male Germline Stem Cell Self-Renewal via Targeting PLZF.

    Science.gov (United States)

    Song, Wencong; Mu, Hailong; Wu, Jiang; Liao, Mingzhi; Zhu, Haijing; Zheng, Liming; He, Xin; Niu, Bowen; Zhai, Yuanxin; Bai, Chunling; Lei, Anmin; Li, Guangpeng; Hua, Jinlian

    2015-10-01

    The balance between the self-renewal and differentiation of male germline stem cells (mGSCs) is critical for the initiation and maintenance of mammalian spermatogenesis. The promyelocytic leukemia zinc finger (PLZF), a zinc finger protein, is a critical factor for maintaining the self-renewal of mGSCs, so, evaluation of the PLZF pathway in mGSCs may provide a deeper insight into mammalian spermatogenesis. miRNA was also an important regulating factor for the self-renewal and differentiation of mGSCs; however, there is currently no data indicating that which miRNA regulate the self-renewal and differentiation of mGSCs via PLZF. Here, we predicted the prospective miRNA targeting to PLZF using the online Bioinformatics database-Targetscan, and performed an analysis of the dual-luciferase recombinant vector, psiCHCEKTM-2-PLZF-3'UTR. miR-544 mimics (miR-544m), miR-544 inhibitors (miR-544i), Control (NC, scrambled oligonucleotides transfection), pPLZF-IRES2-EGFP or PLZF siRNA were transfected into mGSCs; the cells proliferation was evaluated by BRDU incorporation assay and flow cytometry, and the mGSC marker, GFRa1, PLZF, KIT, DAZL, and VASA expression were analyzed by RT-qPCR, immunofluorescence and Western blot. The results showed that miR-544 regulates dairy goat male germline stem cell self-renewal via targeting PLZF. Our study identifies a new regulatory pathway for PLZF and expands upon the PLZF regulatory network in mGSCs.

  19. Renewable build-up pathways for the US: Generation costs are not system costs

    CERN Document Server

    Becker, Sarah; Andresen, Gorm B; Jacobson, Mark Z; Schramm, Stefan; Greiner, Martin

    2014-01-01

    The transition to a future electricity system based primarily on wind and solar PV is examined for all regions in the contiguous US. We present optimized pathways for the build-up of wind and solar power for least backup energy needs as well as for least cost obtained with a simplified, lightweight model based on long-term high resolution weather-determined generation data. In the absence of storage, the pathway which achieves the best match of generation and load, thus resulting in the least backup energy requirements, generally favors a combination of both technologies, with a wind/solar PV energy mix of about 80/20 in a fully renewable scenario. The least cost development is seen to start with 100% of the technology with the lowest average generation costs first, but with increasing renewable installations, economically unfavorable excess generation pushes it toward the minimal backup pathway. Surplus generation and the entailed costs can be reduced significantly by combining wind and solar power, and/or a...

  20. The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.

    Science.gov (United States)

    Boroviak, Thorsten; Loos, Remco; Bertone, Paul; Smith, Austin; Nichols, Jennifer

    2014-06-01

    The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs. Marker profiling shows that ESCs are distinct from early inner cell mass (ICM) and closely resemble pre-implantation epiblast. A characteristic feature of mouse ESCs is propagation without ERK signalling. Single-cell culture reveals that cell-autonomous capacity to thrive when the ERK pathway is inhibited arises late during blastocyst development and is lost after implantation. The frequency of deriving clonal ESC lines suggests that all E4.5 epiblast cells can become ESCs. We further show that ICM cells from early blastocysts can progress to ERK independence if provided with a specific laminin substrate. These findings suggest that formation of the epiblast coincides with competence for ERK-independent self-renewal in vitro and consequent propagation as ESC lines.

  1. Changing the Energy System towards Renewable Energy Self-Sufficiency—Towards a multi-perspective and Interdisciplinary Framework

    Directory of Open Access Journals (Sweden)

    Chantal Ruppert-Winkel

    2014-05-01

    Full Text Available The transformation of the present energy system into a sustainable one is discussed worldwide. This is also mirrored in a vivid debate in the scientific literature [1–3]. Self-sufficiency attained with the help of electricity, heat, and fuel from renewable energy (RE in combination with energy saving is seen as one way to establish a sustainable energy system, e.g., [4,5]. Many communities and regions in different countries are facing the challenge of such a transformation of their energy system, and have taken up the objective of achieving energy self-sufficiency through the use of renewables [4,6–8]. [...

  2. Advanced Heat/Mass Exchanger Technology for Geothermal and Solar Renewable Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Greiner, Miles [Univ. of Nevada, Reno, NV (United States); Childress, Amy [Univ. of Nevada, Reno, NV (United States); Hiibel, Sage [Univ. of Nevada, Reno, NV (United States); Kim, Kwang [Univ. of Nevada, Reno, NV (United States); Park, Chanwoo [Univ. of Nevada, Reno, NV (United States); Wirtz, Richard [Univ. of Nevada, Reno, NV (United States)

    2014-12-16

    Northern Nevada has abundant geothermal and solar energy resources, and these renewable energy sources provide an ample opportunity to produce economically viable power. Heat/mass exchangers are essential components to any energy conversion system. Improvements in the heat/mass exchange process will lead to smaller, less costly (more efficient) systems. There is an emerging heat transfer technology, based on micro/nano/molecular-scale surface science that can be applied to heat/mass exchanger design. The objective is to develop and characterize unique coating materials, surface configurations and membranes capable of accommodating a 10-fold increase in heat/mass exchanger performance via phase change processes (boiling, condensation, etc.) and single phase convective heat/mass transfer.

  3. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

    Science.gov (United States)

    Latos, Paulina A; Goncalves, Angela; Oxley, David; Mohammed, Hisham; Turro, Ernest; Hemberger, Myriam

    2015-07-24

    Esrrb (oestrogen-related receptor beta) is a transcription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine lethality due to defects in trophoblast development. Here we show that in trophoblast stem (TS) cells, Esrrb is a downstream target of fibroblast growth factor (Fgf) signalling and is critical to drive TS cell self-renewal. In contrast to its occupancy of pluripotency-associated loci in ES cells, Esrrb sustains the stemness of TS cells by direct binding and regulation of TS cell-specific transcription factors including Elf5 and Eomes. To elucidate the mechanisms whereby Esrrb controls the expression of its targets, we characterized its TS cell-specific interactome using mass spectrometry. Unlike in ES cells, Esrrb interacts in TS cells with the histone demethylase Lsd1 and with the RNA Polymerase II-associated Integrator complex. Our findings provide new insights into both the general and context-dependent wiring of transcription factor networks in stem cells by master transcription factors.

  4. Hybrid Geo-Energy Systems for Energy Storage and Dispatchable Renewable and Low-Carbon Electricity

    Science.gov (United States)

    Buscheck, Thomas; Bielicki, Jeffrey; Ogland-Hand, Jonathan; Hao, Yue; Sun, Yunwei; Randolph, Jimmy; Saar, Martin

    2015-04-01

    Three primary challenges for energy systems are to (1) reduce the amount of carbon dioxide (CO2) being emitted to the atmosphere, (2) increase the penetration of renewable energy technologies, and (3) reduce the water intensity of energy production. Integrating variable renewable energy sources (wind, sunlight) into electric grids requires advances in energy storage approaches, which are currently expensive, and tend to have limited capacity and/or geographic deployment potential. Our approach uses CO2, that would otherwise be emitted to the atmosphere, to generate electricity from geothermal resources, to store excess energy from variable (wind, solar photovoltaic) and thermal (nuclear, fossil, concentrated solar power) sources, and to thus enable increased penetration of renewable energy technologies. We take advantage of the enormous fluid and thermal storage capacity of the subsurface to harvest, store, and dispatch energy. Our approach uses permeable geologic formations that are vertically bounded by impermeable layers to constrain pressure and the migration of buoyant CO2 and heated brine. Supercritical CO2 captured from fossil power plants is injected into these formations as a cushion gas to store pressure (bulk energy), provide an heat efficient extraction fluid for efficient power conversion in Brayton Cycle turbines, and generate artesian flow of brine -- which can be used to cool power plants and/or pre-heated (thermal storage) prior to re-injection. Concentric rings of injection and production wells create a hydraulic divide to store pressure, CO2, and thermal energy. The system is pressurized and/or heated when power supply exceeds demand and depressurized when demand exceeds supply. Time-shifting the parasitic loads from pressurizing and injecting brine and CO2 provides bulk energy storage over days to months, whereas time-shifting thermal-energy supply provides dispatchable power and addresses seasonal mismatches between supply and demand. These

  5. Renewable Energy Systems: Development and Perspectives of a Hybrid Solar-Wind System

    Directory of Open Access Journals (Sweden)

    C. Shashidhar

    2012-02-01

    Full Text Available Considering the intermittent natural energy resources and the seasonal un-balance, a phtovoltaic-wind hybrid electrical power supply system was developed to accommodate remote locations where a conventional grid connection is inconvenient or expensive. However, the hybrid system can also be applied with grid connection and owners are allowed to sell excessive power back to the electric utility. The proposed set-up consists of a photo-voltaic solar-cell array, a mast mounted wind generator, lead-acid storage batteries, an inverter unit to convert DC to AC, electrical lighting loads, electrical heating loads, several fuse and junction boxes and associated wiring, and test instruments for measuring voltages, currents, power factors, and harmonic contamination data throughout the system. The proposed hybrid solar-wind power generating system can be extensively used to illustrate electrical concepts in hands-on laboratories and also for demonstrations in the Industrial Technology curriculum. This paper describes an analysis of local PV-wind hybrid systems for supplying electricity to a private house, farmhouse or small company with electrical power depending on the site needs. The major system components, work principle and specific working condition are presented.

  6. Adoption of innovation: Wood pellet heating system in the renewable residential energy context

    Energy Technology Data Exchange (ETDEWEB)

    Tapaninen, A.

    2010-07-01

    Getting a new idea widely adopted is difficult. For companies, therefore, it is fundamental that customers are willing to adopt the provided idea or a technological system. Understanding customers, their perceptions, and the attributes influencing the decision to adopt is essential. Thus, this research focused on customers of residential heating, particularly wood pellet heating systems. Accordingly, this research dissects the adoption of innovation in a renewable residential heating energy context, particularly what influences the decision to adopt the wood pellet heating system. A vast amount of literature on the adoption of innovation was reviewed from the innovation and customer perspectives. To gain information about customers and their perceptions, a survey (N=154) was conducted in 2007. Both quantitative and qualitative methods were used in analyzing the results; in particular, the content analysis method was utilized. The research results showed that personal attributes influence issues related to the adoption of wood pellet heating systems. In particular, first, men had more perceived familiarity and knowledge than women regarding issues related to the adoption of wood pellet heating systems. Second, age influenced the intention to select a new heating system; the intention to do was grater in respondents aged 35-44 compared to those aged 25-34. Furthermore, the research demonstrated that information related to wood pellet and technologies is communicated in several kinds of publications and that communication increased during the observation period, especially during the 21st century. In addition, the perceived acquisition factors, i.e., barriers and criteria, of the wood pellet heating system influencing the decision to adopt the system were examined. The factors were primarily categorized according to Rogers' characteristics of innovation. The categorization showed differences between characteristics of innovation influencing the decision to adopt

  7. Hematopoietic stem cells, overview and pathways implied on their self-renewal mechanisms

    OpenAIRE

    2010-01-01

    Blood tissue is composed approximately in 45% by cells and its derivatives, with a life span of around 120 days for erythrocytes and 3 years for certain type of lymphocytes. This lost is compensated with the hematopoietic system activity and the presence of an immature primitive cell population known as Hematopoietic Stem Cells (HSCs) which perform the hematopoiesis, a process that is active from the beginning of the fetal life and produces near to 2 x 1011 eritrocytes and 1010 white blood ce...

  8. The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells.

    Directory of Open Access Journals (Sweden)

    Ming Zhan

    Full Text Available Embryonic stem cells (ESCs are pluripotent and have unlimited self-renewal capacity. Although pluripotency and differentiation have been examined extensively, the mechanisms responsible for self-renewal are poorly understood and are believed to involve an unusual cell cycle, epigenetic regulators and pluripotency-promoting transcription factors. Here we show that B-MYB, a cell cycle regulated phosphoprotein and transcription factor critical to the formation of inner cell mass, is central to the transcriptional and co-regulatory networks that sustain normal cell cycle progression and self-renewal properties of ESCs. Phenotypically, B-MYB is robustly expressed in ESCs and induced pluripotent stem cells (iPSCs, and it is present predominantly in a hypo-phosphorylated state. Knockdown of B-MYB results in functional cell cycle abnormalities that involve S, G2 and M phases, and reduced expression of critical cell cycle regulators like ccnb1 and plk1. By conducting gene expression profiling on control and B-MYB deficient cells, ChIP-chip experiments, and integrative computational analyses, we unraveled a highly complex B-MYB-mediated transcriptional network that guides ESC self-renewal. The network encompasses critical regulators of all cell cycle phases and epigenetic regulators, pluripotency transcription factors, and differentiation determinants. B-MYB along with E2F1 and c-MYC preferentially co-regulate cell cycle target genes. B-MYB also co-targets genes regulated by OCT4, SOX2 and NANOG that are significantly associated with stem cell differentiation, embryonic development, and epigenetic control. Moreover, loss of B-MYB leads to a breakdown of the transcriptional hierarchy present in ESCs. These results coupled with functional studies demonstrate that B-MYB not only controls and accelerates cell cycle progression in ESCs it contributes to fate decisions and maintenance of pluripotent stem cell identity.

  9. The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells.

    Science.gov (United States)

    Zhan, Ming; Riordon, Daniel R; Yan, Bin; Tarasova, Yelena S; Bruweleit, Sarah; Tarasov, Kirill V; Li, Ronald A; Wersto, Robert P; Boheler, Kenneth R

    2012-01-01

    Embryonic stem cells (ESCs) are pluripotent and have unlimited self-renewal capacity. Although pluripotency and differentiation have been examined extensively, the mechanisms responsible for self-renewal are poorly understood and are believed to involve an unusual cell cycle, epigenetic regulators and pluripotency-promoting transcription factors. Here we show that B-MYB, a cell cycle regulated phosphoprotein and transcription factor critical to the formation of inner cell mass, is central to the transcriptional and co-regulatory networks that sustain normal cell cycle progression and self-renewal properties of ESCs. Phenotypically, B-MYB is robustly expressed in ESCs and induced pluripotent stem cells (iPSCs), and it is present predominantly in a hypo-phosphorylated state. Knockdown of B-MYB results in functional cell cycle abnormalities that involve S, G2 and M phases, and reduced expression of critical cell cycle regulators like ccnb1 and plk1. By conducting gene expression profiling on control and B-MYB deficient cells, ChIP-chip experiments, and integrative computational analyses, we unraveled a highly complex B-MYB-mediated transcriptional network that guides ESC self-renewal. The network encompasses critical regulators of all cell cycle phases and epigenetic regulators, pluripotency transcription factors, and differentiation determinants. B-MYB along with E2F1 and c-MYC preferentially co-regulate cell cycle target genes. B-MYB also co-targets genes regulated by OCT4, SOX2 and NANOG that are significantly associated with stem cell differentiation, embryonic development, and epigenetic control. Moreover, loss of B-MYB leads to a breakdown of the transcriptional hierarchy present in ESCs. These results coupled with functional studies demonstrate that B-MYB not only controls and accelerates cell cycle progression in ESCs it contributes to fate decisions and maintenance of pluripotent stem cell identity.

  10. Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation.

    Directory of Open Access Journals (Sweden)

    Christine J Jung

    Full Text Available The self-renewal capacity ascribed to hESCs is paralleled in cancer cell proliferation, suggesting that a common network of genes may facilitate the promotion of these traits. However, the molecular mechanisms that are involved in regulating the silencing of these genes as stem cells differentiate into quiescent cellular lineages remain poorly understood. Here, we show that a differentiated cell specific miR-122 exemplifies this regulatory attribute by suppressing the translation of a gene, Pkm2, which is commonly enriched in hESCs and liver cancer cells (HCCs, and facilitates self-renewal and proliferation. Through a series of gene expression analysis, we show that miR-122 expression is highly elevated in quiescent human primary hepatocytes (hPHs but lost or attenuated in hESCs and HCCs, while an opposing expression pattern is observed for Pkm2. Depleting hESCs and HCCs of Pkm2, or overexpressing miR-122, leads to a common deficiency in self-renewal and proliferation. Likewise, during the differentiation process of hESCs into hepatocytes, a reciprocal expression pattern is observed between miR-122 and Pkm2. An examination of the genomic region upstream of miR-122 uncovered hyper-methylation in hESCs and HCCs, while the same region is de-methylated and occupied by a transcription initiating protein, RNA polymerase II (RNAPII, in hPHs. These findings indicate that one possible mechanism by which hESC self-renewal is modulated in quiescent hepatic derivatives of hESCs is through the regulatory activity of a differentiated cell-specific miR-122, and that a failure to properly turn "on" this miRNA is observed in uncontrollably proliferating HCCs.

  11. Developing common information elements for renewable energy systems: summary and proceedings of the SERI/AID workshop

    Energy Technology Data Exchange (ETDEWEB)

    Ashworth, J.H.; Neuendorffer, J.W.

    1980-06-01

    This report describes the activities, conclusions, and recommendations of the Workshop on Evaluation Systems for Renewable Energy Systems sponsored by the Agency for International Development and SERI, held 20-22 February 1980 in Golden, Colorado. The primary objectives of the workshop was to explore whether it was possible to establish common information elements that would describe the operation and impact of renewable energy projects in developing countries. The workshop provided a forum for development program managers to discuss the information they would like to receive about renewable energy projects and to determine whether common data could be agreed on to facilitate information exchange among development organizations. Such information could be shared among institutions and used to make informed judyments on the economic, technical, and social feasibility of the technologies. Because developing countries and foreign assistance agencies will be financing an increasing number of renewable energy projects, these organizations need information on the field experience of renewable energy technologies. The report describes the substance of the workshop discussions and includes the papers presented on information systems and technology evaluation and provides lists of important information elements generated by both the plenary sessions and the small working groups.

  12. An integrated system for the energy production and accumulation from renewable sources: a rural tower prototype

    Science.gov (United States)

    Di Francesco, Silvia; Petrozzi, Alessandro; Montesarchio, Valeria

    2014-05-01

    This research work presents the implementation of an architectural prototype aiming at the complete energy self-sufficiency through an integrated system based on renewable energy. It is suitable for historical buildings in rural areas, isolated but important from natural and architectonical point of view. In addition to the energy aspects, it is important to protect the impact in terms of land-use and environment. This idea is also especially powerful because in the rural countries there are many little building centers abandoned because they are devoid of a connection to the electric energy grid and methane piping. Thus, taking inspiration from dove towers, architectural typology widespread in central Italy, a virtual model has been developed as an integrated system for renewable energy production, storage and supply. While recovering the ancient tower, it is possible to design and assembly an integrated intelligent system, able to combine energy supply and demand: a new tower that should be flexible, efficient and replicable in other contexts as manufacturing, commercial and residential ones. The prototype has been applied to a real case of study, an ancient complex located in Umbria Region. The sources for electric production installed on the tower are photovoltaics, on the head and shaft of the tower, hydropower and a biomass gasifier providing thermal too. A tank at the head of the tower allows an available hydraulic potential energy, for the turbine at any time, to cover photovoltaic lacks, caused by sudden loss of production, for environmental causes. Conversely, photovoltaic peaks, otherwise unusable, can be used to reload the water from the receiving tank at the foot of the tower, up to the tank in the head. The same underground tank acts as a thermal flywheel to optimize the geothermal heat pumps for the heat and cold production. Keywords: hydropower, photovoltaics, dove tower.

  13. 78 FR 49282 - Renewal of Agency Information Collection for Reporting Systems for Public Law 102-477...

    Science.gov (United States)

    2013-08-13

    ... Bureau of Indian Affairs Renewal of Agency Information Collection for Reporting Systems for Public Law... the collection of information for the Reporting System for Public Law 102-477 Demonstration Project... Public Law 102-477 Demonstration Project. This information allows the Office of Indian Energy...

  14. 75 FR 58423 - Renewal of Agency Information Collection for Reporting System for Public Law 102-477...

    Science.gov (United States)

    2010-09-24

    ... Bureau of Indian Affairs Renewal of Agency Information Collection for Reporting System for Public Law 102..., Reporting System for Public Law 102-477 Demonstration Project. This information collection allows IEED to... integrated programs. Public Law 102-477 authorizes tribal governments to integrate...

  15. Towards a European renewable-based energy system enabled by smart grid: status and prospects

    DEFF Research Database (Denmark)

    Ding, Yi; Østergaard, Jacob; Wu, Qiuwei

    2011-01-01

    Renewable energy plays an important role in the future energy framework of the European Union. The European Union will reach a 20% share of renewable energy in total energy consumption and increase energy efficiency by 20% by 2020. Smart grids will be the backbone of the future electricity network...... for integrating the high penetration of renewable energy resources. The plans and status of renewable energy resources development and energy policy in Europe are introduced in this paper. The development of smart grid technologies in the European Union is also discussed. The role of Denmark, one of the leading...... countries for developing renewable energy technologies and using renewable energy resources has been emphasized in this paper. ©2011 State Grid Electric Power Research Institute Press....

  16. Production of Hydrogen for Clean and Renewable Source of Energy for Fuel Cell Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Xunming; Ingler, William B, Jr.; Abraham, Martin; Castellano, Felix; Coleman, Maria; Collins, Robert; Compaan, Alvin; Giolando, Dean; Jayatissa, Ahalapitiya. H.; Stuart, Thomas; Vonderembse, Mark

    2008-10-31

    This was a two-year project that had two major components: 1) the demonstration of a PV-electrolysis system that has separate PV system and electrolysis unit and the hydrogen generated is to be used to power a fuel cell based vehicle; 2) the development of technologies for generation of hydrogen through photoelectrochemical process and bio-mass derived resources. Development under this project could lead to the achievement of DOE technical target related to PEC hydrogen production at low cost. The PEC part of the project is focused on the development of photoelectrochemical hydrogen generation devices and systems using thin-film silicon based solar cells. Two approaches are taken for the development of efficient and durable photoelectrochemical cells; 1) An immersion-type photoelectrochemical cells (Task 3) where the photoelectrode is immersed in electrolyte, and 2) A substrate-type photoelectrochemical cell (Task 2) where the photoelectrode is not in direct contact with electrolyte. Four tasks are being carried out: Task 1: Design and analysis of DC voltage regulation system for direct PV-to-electrolyzer power feed Task 2: Development of advanced materials for substrate-type PEC cells Task 3: Development of advanced materials for immersion-type PEC cells Task 4: Hydrogen production through conversion of biomass-derived wastes

  17. An approach to modeling and optimization of integrated renewable energy system (ires)

    Science.gov (United States)

    Maheshwari, Zeel

    The purpose of this study was to cost optimize electrical part of IRES (Integrated Renewable Energy Systems) using HOMER and maximize the utilization of resources using MATLAB programming. IRES is an effective and a viable strategy that can be employed to harness renewable energy resources to energize remote rural areas of developing countries. The resource- need matching, which is the basis for IRES makes it possible to provide energy in an efficient and cost effective manner. Modeling and optimization of IRES for a selected study area makes IRES more advantageous when compared to hybrid concepts. A remote rural area with a population of 700 in 120 households and 450 cattle is considered as an example for cost analysis and optimization. Mathematical models for key components of IRES such as biogas generator, hydropower generator, wind turbine, PV system and battery banks are developed. A discussion of the size of water reservoir required is also presented. Modeling of IRES on the basis of need to resource and resource to need matching is pursued to help in optimum use of resources for the needs. Fixed resources such as biogas and water are used in prioritized order whereas movable resources such as wind and solar can be used simultaneously for different priorities. IRES is cost optimized for electricity demand using HOMER software that is developed by the NREL (National Renewable Energy Laboratory). HOMER optimizes configuration for electrical demand only and does not consider other demands such as biogas for cooking and water for domestic and irrigation purposes. Hence an optimization program based on the need-resource modeling of IRES is performed in MATLAB. Optimization of the utilization of resources for several needs is performed. Results obtained from MATLAB clearly show that the available resources can fulfill the demand of the rural areas. Introduction of IRES in rural communities has many socio-economic implications. It brings about improvement in living

  18. The Economic Potential of Nuclear-Renewable Hybrid Energy Systems Producing Hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Mark; Cutler, Dylan; Flores-Espino, Francisco; Stark, Greg

    2017-04-07

    This report is one in a series of reports that Idaho National Laboratory and the Joint Institute for Strategic Energy Analysis are publishing that address the technical and economic aspects of nuclear-renewable hybrid energy systems (N-R HESs). This report discusses an analysis of the economic potential of a tightly coupled N-R HES that produces electricity and hydrogen. Both low and high temperature electrolysis options are considered in the analysis. Low-temperature electrolysis requires only electricity to convert water to hydrogen. High temperature electrolysis requires less electricity because it uses both electricity and heat to provide the energy necessary to electrolyze water. The study finds that, to be profitable, the examined high-temperature electrosis and low-temperature electrosis N-R HES configurations that produce hydrogen require higher electricity prices, more electricity price volatility, higher natural gas prices, or higher capacity payments than the reference case values of these parameters considered in this analysis.

  19. Optimal Hybrid Renewable Airport Power System: Empirical Study on Incheon International Airport, South Korea

    Directory of Open Access Journals (Sweden)

    Seoin Baek

    2016-06-01

    Full Text Available In response to global energy problems (e.g., the oil crisis, the Fukushima accident, the Paris Agreement, the South Korean government has executed a strict renewable energy plan to decrease the country’s dependence on fossil fuel. Public facilities, such as international airports, which use substantial amounts of electricity, are the most in need of government regulation. In this study, we attempt to determine the optimal hybrid electricity generation system for South Korea’s largest airport: Incheon International Airport. In the analysis, we use three scenarios: the current load, 120% of the current load, and 140% of the current load, according to the plan to expand Incheon International Airport. According to the COE (cost of electricity and the NPC (net present cost of the result, it is economically feasible to completely cover the potential increase in the electric load with PV power. Government policy implications and limitations are discussed.

  20. New topology for DC/DC bidirectional converter for hybrid systems in renewable energy

    Science.gov (United States)

    Lopez, Juan Carlos; Ortega, Manuel; Jurado, Francisco

    2015-03-01

    This article presents a new isolated DC/DC bidirectional converter with soft switching, using a transformer with two voltage taps and two full bridges with insulated-gate bipolar transistors (IGBTs), one on each side of the transformer to be integrated in hybrid systems of renewable energy. A large voltage conversion ratio can be achieved using this converter, in buck and booster modes. Also medium and high DC power can be converted with a good efficiency. Analysis and switching techniques have been reported. To verify the principle of operation, a laboratory prototype of 10 kW has been performed. Experimental results are presented, operating in boost mode. The switching algorithm used has been modelled in MATLAB-Simulink to generate C code. This code has been implemented in a DSP F2812, which has been used to build the prototype.

  1. Development of Innovative Heating and Cooling Systems Using Renewable Energy Sources for Non-Residential Buildings

    Directory of Open Access Journals (Sweden)

    Cinzia Buratti

    2013-10-01

    Full Text Available Industrial and commercial areas are synonymous with high energy consumption, both for heating/cooling and electric power requirements, which are in general associated to a massive use of fossil fuels producing consequent greenhouse gas emissions. Two pilot systems, co-funded by the Italian Ministry for the Environment, have been created to upgrade the heating/cooling systems of two existing buildings on the largest industrial estate in Umbria, Italy. The upgrade was specifically designed to improve the system efficiency and to cover the overall energy which needs with renewable energy resources. In both cases a solar photovoltaic plant provides the required electric power. The first system features a geothermal heat pump with an innovative layout: a heat-storage water tank, buried just below ground level, allows a significant reduction of the geothermal unit size, hence requiring fewer and/or shorter boreholes (up to 60%–70%. In the other system a biomass boiler is coupled with an absorption chiller machine, controlling the indoor air temperature in both summer and winter. In this case, lower electricity consumption, if compared to an electric compression chiller, is obtained. The first results of the monitoring of summer cooling are presented and an evaluation of the performance of the two pilot systems is given.

  2. Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells.

    Directory of Open Access Journals (Sweden)

    Ilaria Burba

    Full Text Available BACKGROUND: Use of peripheral blood- or bone marrow-derived progenitors for ischemic heart repair is a feasible option to induce neo-vascularization in ischemic tissues. These cells, named Endothelial Progenitors Cells (EPCs, have been extensively characterized phenotypically and functionally. The clinical efficacy of cardiac repair by EPCs cells remains, however, limited, due to cell autonomous defects as a consequence of risk factors. The devise of "enhancement" strategies has been therefore sought to improve repair ability of these cells and increase the clinical benefit. PRINCIPAL FINDINGS: Pharmacologic inhibition of histone deacetylases (HDACs is known to enhance hematopoietic stem cells engraftment by improvement of self renewal and inhibition of differentiation in the presence of mitogenic stimuli in vitro. In the present study cord blood-derived CD34(+ were pre-conditioned with the HDAC inhibitor Valproic Acid. This treatment affected stem cell growth and gene expression, and improved ischemic myocardium protection in an immunodeficient mouse model of myocardial infarction. CONCLUSIONS: Our results show that HDAC blockade leads to phenotype changes in CD34(+ cells with enhanced self renewal and cardioprotection.

  3. Cell death and renewal during prey capture and digestion in the carnivorous sponge Asbestopluma hypogea (Porifera: Poecilosclerida).

    Science.gov (United States)

    Martinand-Mari, Camille; Vacelet, Jean; Nickel, Michael; Wörheide, Gert; Mangeat, Paul; Baghdiguian, Stephen

    2012-11-15

    The sponge Asbestopluma hypogea is unusual among sponges due to its peculiar carnivorous feeding habit. During various stages of its nutrition cycle, the sponge is subjected to spectacular morphological modifications. Starved animals are characterized by many elongated filaments, which are crucial for the capture of prey. After capture, and during the digestion process, these filaments actively regress before being regenerated during a subsequent period of starvation. Here, we demonstrate that these morphological events rely on a highly dynamic cellular turnover, implying a coordinated sequence of programmed cell death (apoptosis and autophagy), cell proliferation and cell migration. A candidate niche for cell renewal by stem cell proliferation and differentiation was identified at the base of the sponge peduncle, characterized by higher levels of BrdU/EdU incorporation. Therefore, BrdU/EdU-positive cells of the peduncle base are candidate motile cells responsible for the regeneration of the prey-capturing main sponge body, i.e. the dynamic filaments. Altogether, our results demonstrate that dynamics of cell renewal in sponge appear to be regulated by cellular mechanisms as multiple and complex as those already identified in bilaterian metazoans.

  4. Renewable Electricity Futures Study. Volume 4: Bulk Electric Power Systems. Operations and Transmission Planning

    Energy Technology Data Exchange (ETDEWEB)

    Milligan, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ela, Erik [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hein, Jeff [National Renewable Energy Lab. (NREL), Golden, CO (United States); Schneider, Thomas [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brinkman, Gregory [National Renewable Energy Lab. (NREL), Golden, CO (United States); Denholm, Paul [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2012-06-15

    The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a future through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%–90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT). Learn more at the RE Futures website. http://www.nrel.gov/analysis/re_futures/

  5. Renewable Electricity Futures Study. Volume 4: Bulk Electric Power Systems: Operations and Transmission Planning

    Energy Technology Data Exchange (ETDEWEB)

    Milligan, M.; Ela, E.; Hein, J.; Schneider, T.; Brinkman, G.; Denholm, P.

    2012-06-01

    The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a future through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%-90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT).

  6. Signaling pathways in self-renewing hematopoietic and leukemic stem cells : do all stem cells need a niche?

    NARCIS (Netherlands)

    Rizo, Aleksandra; Vellenga, Edo; de Haan, Gerald; Schuringa, Jan Jacob

    2006-01-01

    Many adult tissue stem cells, such as the cells of the hematopoietic system, gastrointestinal epithelium, brain, epidermis, mammary gland and lung have now been identified, all of them fulfilling a crucial role in supplying organisms with mature cells during normal homeostasis as well as in times of

  7. An Oct4-pRb axis, controlled by MiR-335, integrates stem cell self-renewal and cell cycle control.

    Science.gov (United States)

    Schoeftner, Stefan; Scarola, Michele; Comisso, Elisa; Schneider, Claudio; Benetti, Roberta

    2013-04-01

    The pluripotency of mouse embryonic stem cells (mESCs) is controlled by a network of transcription factors, mi-RNAs, and signaling pathways. Here, we present a new regulatory circuit that connects miR-335, Oct4, and the Retinoblastoma pathway to control mESC self-renewal and differentiation. Oct4 drives the expression of Nipp1 and Ccnf that inhibit the activity of the protein phosphatase 1 (PP1) complex to establish hyperphosphorylation of the retinoblastoma protein 1 (pRb) as a hallmark feature of self-renewing mESCs. The Oct4-Nipp1/Ccnf-PP1-pRb axis promoting mESC self-renewal is under control of miR-335 that regulates Oct4 and Rb expression. During mESC differentiation, miR-335 upregulation co-operates with the transcriptional repression of Oct4 to facilitate the collapse of the Oct4-Nipp1/Ccnf-PP1-pRb axis, pRb dephosphorylation, the exit from self-renewal, and the establishment of a pRb-regulated cell cycle program. Our results introduce Oct4-dependent control of the Rb pathway as novel regulatory circuit controlling mESC self-renewal and differentiation.

  8. BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors

    Directory of Open Access Journals (Sweden)

    Masato Morikawa

    2016-01-01

    Full Text Available Bone morphogenetic protein (BMP signaling exerts paradoxical roles in pluripotent stem cells (PSCs; it sustains self-renewal of mouse embryonic stem cells (ESCs, while it induces differentiation in other PSCs, including human ESCs. Here, we revisit the roles of BMP-4 using mouse ESCs (mESCs in naive and primed states. SMAD1 and SMAD5, which transduce BMP signals, recognize enhancer regions together with KLF4 and KLF5 in naive mESCs. KLF4 physically interacts with SMAD1 and suppresses its activity. Consistently, a subpopulation of cells with active BMP-SMAD can be ablated without disturbing the naive state of the culture. Moreover, Smad1/5 double-knockout mESCs stay in the naive state, indicating that the BMP-SMAD pathway is dispensable for it. In contrast, the MEK5-ERK5 pathway mediates BMP-4-induced self-renewal of mESCs by inducing Klf2, a critical factor for the ground state pluripotency. Our study illustrates that BMP exerts its self-renewing effect through distinct functions of different Krüppel-like factors.

  9. Telomerase-immortalized human mammary stem/progenitor cells with ability to self-renew and differentiate.

    Science.gov (United States)

    Zhao, Xiangshan; Malhotra, Gautam K; Lele, Subodh M; Lele, Manjiri S; West, William W; Eudy, James D; Band, Hamid; Band, Vimla

    2010-08-10

    There is increasing evidence that breast and other cancers originate from and are maintained by a small fraction of stem/progenitor cells with self-renewal properties. Whether such cancer stem/progenitor cells originate from normal stem cells based on initiation of a de novo stem cell program, by reprogramming of a more differentiated cell type by oncogenic insults, or both remains unresolved. A major hurdle in addressing these issues is lack of immortal human stem/progenitor cells that can be deliberately manipulated in vitro. We present evidence that normal and human telomerase reverse transcriptase (hTERT)-immortalized human mammary epithelial cells (hMECs) isolated and maintained in Dana-Farber Cancer Institute 1 (DFCI-1) medium retain a fraction with progenitor cell properties. These cells coexpress basal (K5, K14, and vimentin), luminal (E-cadherin, K8, K18, or K19), and stem/progenitor (CD49f, CD29, CD44, and p63) cell markers. Clonal derivatives of progenitors coexpressing these markers fall into two distinct types--a K5(+)/K19(-) type and a K5(+)/K19(+) type. We show that both types of progenitor cells have self-renewal and differentiation ability. Microarray analyses confirmed the differential expression of components of stem/progenitor-associated pathways, such as Notch, Wnt, Hedgehog, and LIF, in progenitor cells compared with differentiated cells. Given the emerging evidence that stem/progenitor cells serve as precursors for cancers, these cellular reagents represent a timely and invaluable resource to explore unresolved questions related to stem/progenitor origin of breast cancer.

  10. An automated overlying water-renewal system for sediment toxicity studies

    Energy Technology Data Exchange (ETDEWEB)

    Rand, G.M.; Wheat, J.V.; Carriger, J.F.; Lee, T.A

    2003-04-01

    A new system is described for sediment toxicity testing. - An automated water-renewal toxicity test system is described for exposing benthic invertebrates to whole sediments. The system will intermittently deliver laboratory or on-site water for overlying water replacement in sediment exposures. A range of cycle rates can be used to produce different volume additions of overlying water per day to exposure chambers. The system can be used with six different treatments and eight replicates per treatment producing 48 exposure chambers. Three formulated sediments with variable organic carbon (1.5%, 7.5%) and sand (14%, 63%) content were prepared to test the system exposing amphipods, Hyalella azteca and midges, Chironomus tentans in 10 day whole sediment tests. Intermittent water flow was used with a 90 min cycle time to create two volume additions of laboratory water per 24 h in exposure chambers (180 ml sediment, 320 ml water). Overlying water quality conditions, and survival and growth of both species were consistent and within acceptable limits for the testing requirements of the U.S. EPA guidelines for sediments with freshwater invertebrates.

  11. Unified System-Level Modeling of Intermittent Renewable Energy Sources and Energy Storage for Power System Operation

    DEFF Research Database (Denmark)

    Heussen, Kai; Koch, Stephan; Ulbig, Andreas

    2011-01-01

    in market-based operation. The design of operation strategies for up to 100 % renewable energy systems requires an explicit consideration of non-dispatchable generation and stor- age capacities, as well as the evaluation of operational performance in terms of energy eciency, reliability, environmental...... impact and cost. By abstracting from technology-dependent and physical unit properties, the modeling framework presented and extended in this pa- per allows the modeling of a technologically diverse unit portfolio with a unied approach, whilst establishing the feasibility of energy-storage consideration...

  12. CXCR6, a newly defined biomarker of tissue-specific stem cell asymmetric self-renewal, identifies more aggressive human melanoma cancer stem cells.

    Directory of Open Access Journals (Sweden)

    Rouzbeh Taghizadeh

    Full Text Available A fundamental problem in cancer research is identifying the cell type that is capable of sustaining neoplastic growth and its origin from normal tissue cells. Recent investigations of a variety of tumor types have shown that phenotypically identifiable and isolable subfractions of cells possess the tumor-forming ability. In the present paper, using two lineage-related human melanoma cell lines, primary melanoma line IGR39 and its metastatic derivative line IGR37, two main observations are reported. The first one is the first phenotypic evidence to support the origin of melanoma cancer stem cells (CSCs from mutated tissue-specific stem cells; and the second one is the identification of a more aggressive subpopulation of CSCs in melanoma that are CXCR6+.We defined CXCR6 as a new biomarker for tissue-specific stem cell asymmetric self-renewal. Thus, the relationship between melanoma formation and ABCG2 and CXCR6 expression was investigated. Consistent with their non-metastatic character, unsorted IGR39 cells formed significantly smaller tumors than unsorted IGR37 cells. In addition, ABCG2+ cells produced tumors that had a 2-fold greater mass than tumors produced by unsorted cells or ABCG2- cells. CXCR6+ cells produced more aggressive tumors. CXCR6 identifies a more discrete subpopulation of cultured human melanoma cells with a more aggressive MCSC phenotype than cells selected on the basis of the ABCG2+ phenotype alone.The association of a more aggressive tumor phenotype with asymmetric self-renewal phenotype reveals a previously unrecognized aspect of tumor cell physiology. Namely, the retention of some tissue-specific stem cell attributes, like the ability to asymmetrically self-renew, impacts the natural history of human tumor development. Knowledge of this new aspect of tumor development and progression may provide new targets for cancer prevention and treatment.

  13. Emergence of a phase transition for the required amount of storage in highly renewable electricity systems

    DEFF Research Database (Denmark)

    Jensen, Tue Vissing; Greiner, Martin

    2014-01-01

    -up of the required amount of storage, with renewable penetration being the control parameter and average relative storage filling level being the order parameter. A singularity appears for the required storage energy capacity at a renewable penetration determined by the parameters of the storage. For an ideal...

  14. Delegating responsibility for environmental transition - are innovations in renewable energy a system, policy or market responsibility?

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik

    2003-01-01

    The European liberalisation of the energy sector has left open questions about the responsibility for future innovations in renewable energy.......The European liberalisation of the energy sector has left open questions about the responsibility for future innovations in renewable energy....

  15. Johnson Space Center's Solar and Wind-Based Renewable Energy System

    Science.gov (United States)

    Vasquez, A.; Ewert, M.; Rowlands, J.; Post, K.

    2009-01-01

    The NASA Johnson Space Center (JSC) in Houston, Texas has a Sustainability Partnership team that seeks ways for earth-based sustainability practices to also benefit space exploration research. A renewable energy gathering system was installed in 2007 at the JSC Child Care Center (CCC) which also offers a potential test bed for space exploration power generation and remote monitoring and control concepts. The system comprises: 1) several different types of photovoltaic panels (29 kW), 2) two wind-turbines (3.6 kW total), and 3) one roof-mounted solar thermal water heater and tank. A tie to the JSC local electrical grid was provided to accommodate excess power. The total first year electrical energy production was 53 megawatt-hours. A web-based real-time metering system collects and reports system performance and weather data. Improvements in areas of the CCC that were detected during subsequent energy analyses and some concepts for future efforts are also presented.

  16. Systematic Evaluation of Stochastic Methods in Power System Scheduling and Dispatch with Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yishen [Univ. of Washington, Seattle, WA (United States); Argonne National Lab. (ANL), Argonne, IL (United States); Zhou, Zhi [Argonne National Lab. (ANL), Argonne, IL (United States); Liu, Cong [Argonne National Lab. (ANL), Argonne, IL (United States); Electric Reliability Council of Texas (ERCOT), Austin, TX (United States); Botterud, Audun [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-08-01

    As more wind power and other renewable resources are being integrated into the electric power grid, the forecast uncertainty brings operational challenges for the power system operators. In this report, different operational strategies for uncertainty management are presented and evaluated. A comprehensive and consistent simulation framework is developed to analyze the performance of different reserve policies and scheduling techniques under uncertainty in wind power. Numerical simulations are conducted on a modified version of the IEEE 118-bus system with a 20% wind penetration level, comparing deterministic, interval, and stochastic unit commitment strategies. The results show that stochastic unit commitment provides a reliable schedule without large increases in operational costs. Moreover, decomposition techniques, such as load shift factor and Benders decomposition, can help in overcoming the computational obstacles to stochastic unit commitment and enable the use of a larger scenario set to represent forecast uncertainty. In contrast, deterministic and interval unit commitment tend to give higher system costs as more reserves are being scheduled to address forecast uncertainty. However, these approaches require a much lower computational effort Choosing a proper lower bound for the forecast uncertainty is important for balancing reliability and system operational cost in deterministic and interval unit commitment. Finally, we find that the introduction of zonal reserve requirements improves reliability, but at the expense of higher operational costs.

  17. PSO-Based Smart Grid Application for Sizing and Optimization of Hybrid Renewable Energy Systems

    Science.gov (United States)

    Mohamed, Mohamed A.; Eltamaly, Ali M.; Alolah, Abdulrahman I.

    2016-01-01

    This paper introduces an optimal sizing algorithm for a hybrid renewable energy system using smart grid load management application based on the available generation. This algorithm aims to maximize the system energy production and meet the load demand with minimum cost and highest reliability. This system is formed by photovoltaic array, wind turbines, storage batteries, and diesel generator as a backup source of energy. Demand profile shaping as one of the smart grid applications is introduced in this paper using load shifting-based load priority. Particle swarm optimization is used in this algorithm to determine the optimum size of the system components. The results obtained from this algorithm are compared with those from the iterative optimization technique to assess the adequacy of the proposed algorithm. The study in this paper is performed in some of the remote areas in Saudi Arabia and can be expanded to any similar regions around the world. Numerous valuable results are extracted from this study that could help researchers and decision makers. PMID:27513000

  18. Strategies for the integration of intermittent renewable energy sources in the electrical system

    Science.gov (United States)

    Romanelli, Francesco

    2016-03-01

    Europe is pursuing an aggressive programme to increase its share of renewable energy source (RES). However, the integration of intermittent RES (wind and photovoltaic) in the electrical system requires either maintaining in operation thermal backup systems or providing a substantial amount of electricity storage. We analyze the Italian electricity data for the year 2013 provided by the transmission system operator TERNA. The present level of intermittent RES power is scaled-up to a level at which it generates an amount of electricity equal to the annual demand. While a substantial reduction of the energy annually produced by fossil backup systems (and the associated CO2 emission) with respect to the no-RES case is possible in many scenarios considered here, the backup power is generally only marginally reduced below the value in the absence of RES. The strategy proposed is based on the combination of a modest amount of storage (0.5-5TWh) and base-load power (6-15GW, to be used during the seasons of low RES production). In this way the non-RES installed power can be reduced from ˜ 50 GW to less than 15GW and could be covered by a combination of biomass and nuclear energy without any CO2 emission.

  19. Analysis of SFCL’s in DC System with Renewable Energy Sources

    Directory of Open Access Journals (Sweden)

    S. Mohanram

    2015-12-01

    Full Text Available Superconducting fault-current limiters (SFCLs have been the subject of research and development for many years and offer an attractive solution to the problem of rising fault levels in electrical distribution systems. SFCLs can greatly reduce fault currents and the damage at the point of fault, and help improve the stability of a power system. Superconducting fault-current limiters (SFCL provide a new efficient approach to the reliable handling of such faults.(SCFLs can be used for various nominal voltages and currents, and can be adapted to particular limiting characteristics in case of short circuits. In this project, dc resistive type superconducting fault current limiter (SFCL is presented. This SFCL is designed for the HVDC system. Uniform current and voltage sharing among the SFCL modules can be observed through contact resistance tests, dc flow-through tests, and ac flow-through tests. Results of tests show that each limiting module has good uniformity in higher current system. The proposed concept can be implemented using renewable energy sources. The results are presented by using Matlab / simulink platform.

  20. PSO-Based Smart Grid Application for Sizing and Optimization of Hybrid Renewable Energy Systems.

    Science.gov (United States)

    Mohamed, Mohamed A; Eltamaly, Ali M; Alolah, Abdulrahman I

    2016-01-01

    This paper introduces an optimal sizing algorithm for a hybrid renewable energy system using smart grid load management application based on the available generation. This algorithm aims to maximize the system energy production and meet the load demand with minimum cost and highest reliability. This system is formed by photovoltaic array, wind turbines, storage batteries, and diesel generator as a backup source of energy. Demand profile shaping as one of the smart grid applications is introduced in this paper using load shifting-based load priority. Particle swarm optimization is used in this algorithm to determine the optimum size of the system components. The results obtained from this algorithm are compared with those from the iterative optimization technique to assess the adequacy of the proposed algorithm. The study in this paper is performed in some of the remote areas in Saudi Arabia and can be expanded to any similar regions around the world. Numerous valuable results are extracted from this study that could help researchers and decision makers.

  1. Integration of renewable energies and nuclear power into North African Energy Systems: An analysis of energy import and export effects

    Energy Technology Data Exchange (ETDEWEB)

    Supersberger, Nikolaus, E-mail: nikolaus.supersberger@giz.de [Wuppertal Institute for Climate, Environment, Energy, P.O. Box 10 04 80, 42004 Wuppertal (Germany); Fuehrer, Laura, E-mail: laura.fuhrer@sciences-po.org [Sciences Po Paris, College Universitaire, Campus de Menton, du College Chemin du College, 06500 Menton (France)

    2011-08-15

    The North African countries Morocco, Algeria, Tunisia, Libya and Egypt have been and are currently experiencing rapid growth in energy demand. This development confronts their political leaders with the question of how to expand or diversify their countries' generation capacities. In this context, renewable energies and nuclear power constitute options that have rarely been exploited so far in the region. This article analyzes the drawbacks and benefits of both alternatives, with a special focus on import and export dynamics. When attempting to make the strategic decision between renewables and atomic power, North African regional specifics and circumstances have to be taken into account. Hence, in a first step, the article characterizes the energy systems of the North African countries and presents scenarios for their future development. In a second step, it scrutinizes the energy challenges these states face in terms of domestic concerns and foreign affairs. Finally, a case study of Algeria is used to demonstrate how renewable energies, but not nuclear power, are able to respond to North African energy challenges. - Research Highlights: > Using nuclear power would require fuel imports over the entire operation time. > Hence, energy exporters (Algeria, Libya) would become dependent on fuel imports. > Renewable energies can make North African countries less fuel import dependent. > Nuclear technologies would have to be imported over the whole life cycle of plants. > Domestic production for renewables technologies could be established after a first phase of technology imports.

  2. Feasibility Analysis and Simulation of Integrated Renewable Energy System for Power Generation: A Hypothetical Study of Rural Health Clinic

    Directory of Open Access Journals (Sweden)

    Vincent Anayochukwu Ani

    2015-01-01

    Full Text Available This paper presents the feasibility analysis and study of integrated renewable energy (IRE using solar photovoltaic (PV and wind turbine (WT system in a hypothetical study of rural health clinic in Borno State, Nigeria. Electrical power consumption and metrology data (such as solar radiation and wind speed were used for designing and analyzing the integrated renewable energy system. The health clinic facility energy consumption is 19 kWh/day with a 3.4 kW peak demand load. The metrological data was collected from National Aeronautics and Space Administration (NASA website and used to analyze the performance of electrical generation system using HOMER program. The simulation and optimization results show that the optimal integrated renewable energy system configuration consists of 5 kW PV array, BWC Excel-R 7.5 kW DC wind turbine, 24 unit Surrette 6CS25P battery cycle charging, and a 19 kW AC/DC converter and that the PV power can generate electricity at 9,138 kWh/year while the wind turbine system can generate electricity at 7,490 kWh/year, giving the total electrical generation of the system as 16,628 kWh/year. This would be suitable for deployment of 100% clean energy for uninterruptable power performance in the health clinic. The economics analysis result found that the integrated renewable system has total NPC of 137,139 US Dollar. The results of this research show that, with a low energy health facility, it is possible to meet the entire annual energy demand of a health clinic solely through a stand-alone integrated renewable PV/wind energy supply.

  3. Energy management strategy based on short-term generation scheduling for a renewable microgrid using a hydrogen storage system

    DEFF Research Database (Denmark)

    Cau, Giorgo; Cocco, Daniele; Petrollese, Mario;

    2014-01-01

    scheduling of storage devices is carried out to maximize the benefits of available renewable resources by operating the photovoltaic systems and the wind turbine at their maximum power points and by minimizing the overall utilization costs. Unlike conventional EMS based on the state-of-charge (SOC......) of batteries, the proposed EMS takes into account the uncertainty due to the intermittent nature of renewable resources and electricity demand. In particular, the uncertainties are evaluated with a stochastic approach through the construction of different scenarios with corresponding probabilities. The EMS...

  4. Intelligent Decision-Making System with Green Pervasive Computing for Renewable Energy Business in Electricity Markets on Smart Grid

    Directory of Open Access Journals (Sweden)

    Park JongHyuk

    2009-01-01

    Full Text Available This paper is about the intelligent decision-making system for the smart grid based electricity market which requires distributed decision making on the competitive environments composed of many players and components. It is very important to consider the renewable energy and emission problem which are expected to be monitored by wireless communication networks. It is very difficult to predict renewable energy outputs and emission prices over time horizon, so it could be helpful to catch up those data on real time basis using many different kinds of communication infrastructures. On this backgrounds this paper provides an algorithm to make an optimal decision considering above factors.

  5. Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.

    Science.gov (United States)

    Zhang, Cheng Cheng; Steele, Andrew D; Lindquist, Susan; Lodish, Harvey F

    2006-02-14

    Although the wild-type prion protein (PrP) is abundant and widely expressed in various types of tissues and cells, its physiological function(s) remain unknown, and PrP knockout mice do not exhibit overt and undisputed phenotypes. Here we showed that PrP is expressed on the surface of several bone marrow cell populations successively enriched in long-term (LT) hematopoietic stem cells (HSCs) using flow cytometry analysis. Affinity purification of the PrP-positive and -negative fractions from these populations, followed by competitive bone marrow reconstitution assays, shows that all LT HSCs express PrP. HSCs from PrP-null bone marrow exhibited impaired self-renewal in serial transplantation of lethally irradiated mouse recipients both in the presence and absence of competitors. When treated with a cell cycle-specific myelotoxic agent, the animals reconstituted with PrP-null HSCs exhibit increased sensitivity to hematopoietic cell depletion. Ectopic expression of PrP in PrP-null bone marrow cells by retroviral infection rescued the defective hematopoietic engraftment during serial transplantation. Therefore, PrP is a marker for HSCs and supports their self-renewal.

  6. Different Predictive Control Strategies for Active Load Management in Distributed Power Systems with High Penetration of Renewable Energy Sources

    DEFF Research Database (Denmark)

    Zong, Yi; Bindner, Henrik W.; Gehrke, Oliver

    2013-01-01

    In order to achieve a Danish energy supply based on 100% renewable energy from combinations of wind, biomass, wave and solar power in 2050 and to cover 50% of the Danish electricity consumption by wind power in 2020, it requires more renewable energy in buildings and industries (e.g. cold stores...... and residential sectors, based on dynamic power price and weather forecast, considering users’ comfort settings to meet an optimization objective, such as maximum profit or minimum energy consumption. Some field tests were carried out on a facility for intelligent, active and distributed power systems, which...... is built around a small power grid with renewable power generations (two wind turbines and solar panels), a vanadium battery for storage, EV-charging infrastructure for EVs, and an intelligent office building. The simulation and field tests demonstrated that GA-based and MPC-based predictive control...

  7. Backup of renewable energy for an electrical island: case study of Israeli electricity system--current status.

    Science.gov (United States)

    Fakhouri, A; Kuperman, A

    2014-01-01

    The paper focuses on the quantitative analysis of Israeli Government's targets of 10% renewable energy penetration by 2020 and determining the desired methodology (models) for assessing the effects on the electricity market, addressing the fact that Israel is an electricity island. The main objective is to determine the influence of achieving the Government's goals for renewable energy penetration on the need for backup in the Israeli electricity system. This work presents the current situation of the Israeli electricity market and the study to be taken in order to assess the undesirable effects resulting from the intermittency of electricity generated by wind and solar power stations as well as presents some solutions to mitigating these phenomena. Future work will focus on a quantitative analysis of model runs and determine the amounts of backup required relative to the amount of installed capacity from renewable resources.

  8. Impacts of large-scale Intermittent Renewable Energy Sources on electricity systems, and how these can be modeled

    NARCIS (Netherlands)

    Brouwer, Anne Sjoerd; Van Den Broek, Machteld; Seebregts, Ad; Faaij, André

    2014-01-01

    The electricity sector in OECD countries is on the brink of a large shift towards low-carbon electricity generation. Power systems after 2030 may consist largely of two low-carbon generator types: Intermittent Renewable Energy Sources (IRES) such as wind and solar PV and thermal generators such as p

  9. Implementation and Control of a Residential Electrothermal Microgrid Based on Renewable Energies, a Hybrid Storage System and Demand Side Management

    Directory of Open Access Journals (Sweden)

    Julio Pascual

    2014-01-01

    Full Text Available This paper proposes an energy management strategy for a residential electrothermal microgrid, based on renewable energy sources. While grid connected, it makes use of a hybrid electrothermal storage system, formed by a battery and a hot water tank along with an electrical water heater as a controllable load, which make possible the energy management within the microgrid. The microgrid emulates the operation of a single family home with domestic hot water (DHW consumption, a heating, ventilation and air conditioning (HVAC system as well as the typical electric loads. An energy management strategy has been designed which optimizes the power exchanged with the grid profile in terms of peaks and fluctuations, in applications with high penetration levels of renewables. The proposed energy management strategy has been evaluated and validated experimentally in a full scale residential microgrid built in our Renewable Energy Laboratory, by means of continuous operation under real conditions. The results show that the combination of electric and thermal storage systems with controllable loads is a promising technology that could maximize the penetration level of renewable energies in the electric system.

  10. Efficient Simulation Methods of Large Power Systems with High Penetration of Renewable Energy Resources: Theory and Applications

    NARCIS (Netherlands)

    Shayesteh, E.

    2015-01-01

    Electrical energy is one of the most common forms of energy these days. Consequently, electric power system is an indispensable part of any society. However, due to the deregulation of electricity markets and the growth in the share of power generation by uncontrollable renewable energies such as wi

  11. Renewable energy perspectives for the North African electricity systems: a comparative analysis of model-based scenario studies

    NARCIS (Netherlands)

    Brand, B.; Blok, Kornelis

    2015-01-01

    Prospects for the integration of power markets and the expansion of renewable energy have recently triggered a number of publications dealing with transformation scenarios of the North African electricity systems. This paper compares five studies using economic electricity supply- and demand models

  12. 75 FR 26978 - Renewal of Agency Information Collection for Reporting System for Public Law 102-477...

    Science.gov (United States)

    2010-05-13

    ... Bureau of Indian Affairs Renewal of Agency Information Collection for Reporting System for Public Law 102... Public Law 102-477 Demonstration Project. This information collection allows IEED to document.... Public Law 102-477 authorizes tribal governments to integrate federally funded employment, training,...

  13. The Evaluation of the Cognitive Learning Process of the Renewed Bloom Taxonomy Using a Web Based Expert System

    Science.gov (United States)

    Goksu, Idris

    2016-01-01

    The aim of this study is to develop the Web Based Expert System (WBES) which provides analyses and reports based on the cognitive processes of Renewed Bloom Taxonomy (RBT), and to put forward the impact of the supportive education provided in line with these reports, on the academic achievement and mastery learning state of the students. The study…

  14. Biotechnology for renewable chemicals

    DEFF Research Database (Denmark)

    Borodina, Irina; Kildegaard, Kanchana Rueksomtawin; Jensen, Niels Bjerg

    2014-01-01

    The majority of the industrial organic chemicals are derived from fossil sources. With the oil and gas resources becoming limiting, biotechnology offers a sustainable alternative for production ofchemicals from renewable feedstocks. Yeast is an attractive cell factory forsustainable production...

  15. Design and implementation of a marine animal alert system to support Marine Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Zhiqun; Carlson, Thomas J.; Fu, Tao; Ren, Huiying; Martinez, Jayson J.; Myers, Joshua R.; Matzner, Shari; Choi, Eric Y.; Copping, Andrea E.

    2013-08-08

    Power extracted from fast moving tidal currents has been identified as a potential commercial-scale source of renewable energy. Device developers and utilities are pursuing deployment of prototype tidal turbines to assess technology viability, site feasibility, and environmental interactions. Deployment of prototype turbines requires permits from a range of regulatory authorities. Ensuring the safety of marine animals, particularly those under protection of the Endangered Species Act of 1973 (ESA) and the Marine Mammal Protection Act of 1972 has emerged as a key regulatory challenge for initial MHK deployments. The greatest perceived risk to marine animals is from strike by the rotating blades of tidal turbines. Development of the marine mammal alert system (MAAS) was undertaken to support monitoring and mitigation requirements for tidal turbine deployments. The prototype system development focused on Southern Resident killer whales (SRKW), an endangered population of killer whales that frequents Puget Sound and is intermittently present in the part of the sound where deployment of prototype tidal turbines is being considered. Passive acoustics were selected as the primary means because of the vocal nature of these animals. The MAAS passive acoustic system consists of two-stage process involving the use of an energy detector and a spectrogram-based classifier to distinguish between SKRW’s calls and noise. A prototype consisting of two 2D symmetrical star arrays separated by 20 m center to center was built and evaluated in the waters of Sequim Bay using whale call playback.

  16. Optimal combination of energy storages for prospective power supply systems based on Renewable Energy Sources

    CERN Document Server

    Weitemeyer, Stefan; Siemer, Lars; Agert, Carsten

    2016-01-01

    Prospective power supply systems based on Renewable Energy Sources require measures to balance power generation and load at all times. The utilisation of storage devices and backup power plants is widely suggested for this purpose, whereas the best combination is still to be found. In this work, we present a modelling approach to systematically study scenarios of future power supply systems with a high share of electricity originating from wind and solar resources. By considering backup as a subordinate source of electricity with energy-only costs, the approach is independent of the actual full-load hours of the backup power plants. Applying the approach to multi-year meteorological data for Germany, cost-optimised combinations of storage devices and backup power are identified. We find that even in scenarios with significant excess generation capacities there is a need for storage devices or backup power plants with discharging power on the same order as the average load to balance the system at all times. F...

  17. Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?

    Science.gov (United States)

    Tsai, Robert Y L

    2016-05-01

    Stem cells are endowed with the awesome power of self-renewal and multi-lineage differentiation that allows them to be major contributors to tissue homeostasis. Owing to their longevity and self-renewal capacity, they are also faced with a higher risk of genomic damage compared to differentiated cells. Damage on the genome, if not prevented or repaired properly, will threaten the survival of stem cells and culminate in organ failure, premature aging, or cancer formation. It is therefore of paramount importance that stem cells remain genomically stable throughout life. Given their unique biological and functional requirement, stem cells are thought to manage genotoxic stress somewhat differently from non-stem cells. The focus of this article is to review the current knowledge on how stem cells escape the barrage of oxidative and replicative DNA damage to stay in self-renewal. A clear statement on this subject should help us better understand tissue regeneration, aging, and cancer.

  18. Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells.

    Directory of Open Access Journals (Sweden)

    Tong Zhao

    Full Text Available Transcription factor Krüppel-like factor 5 (Klf5 plays important roles in the formation of the inner cell mass (ICM and the trophectoderm during embryogenesis, as well as the self-renewal and the differentiation of mouse embryonic stem cells (ESCs. Acetylation of KLF5 has been shown to reverse the transcriptional activity of KLF5 in human epidermal cells and prostate cancer cells. Whether Klf5 acetylation contributes to the lineage specification in the blastocyst and pluripotency maintenance in ESCs remains unexplored. Here, we showed the ubiquitous expression of acetylated Klf5 in the ICM and the trophectoderm, ruling out the possibility that differential acetylation status of Klf5 leads to the lineage specification in the blastocyst. We found that K358Q mutation, mimicking acetylation, enhances the transcriptional activity of Klf5 for pluripotency genes in ESCs, and that K358Q Klf5 is more potent in pluripotency maintenance and in somatic cell reprogramming, compared to K358R Klf5. In ESCs, Klf5 acetylation, stimulated by TGF-β signaling, is involved in enhancing Sox2 expression. Moreover, upon ESC differentiation, acetylation of Klf5 facilitates the suppression of many differentiation genes, except for that K358Q Klf5 activates Cdx2, promoting trophectodermal differentiation. In summary, our results revealed the regulatory functions of Klf5 acetylation in ESC self-renewal and differentiation.

  19. Feasibility study of renewable energy systems for off-grid islands: A case study concerning Cuttyhunk Island

    Science.gov (United States)

    Gorgen, Marvin Alexander

    Renewable energy can be a promising approach to respond to the energy consumption for remote areas and islands to account for price volatility of fuels, to hedge against supply insecurities, and to establish environmental responsibility. The technology has both, the power to create self-sufficiency in terms of electricity and the ability to be cost-effective and competitive. However, renewable energies are site specific. It is questionable if they are feasible in any environmental condition. Steps that have to be performed, consider different aspects of feasibility and potential of an area of interest. These elements are resource availability, technical practicability, economic reasonableness, and market conditions. The prime objective of this thesis is to assess the feasibility of the renewable energy transition for Cuttyhunk Island in Massachusetts, USA. Cuttyhunk is subject to the constraints of islands' electricity supply and therefore a representative case study. Resource, technical, economic and market analyses have been performed to assess advantages and drawbacks of the site to illustrate conceivable implementation for different system setups. Based on sources open to public, information from local residents and information gathered during a field investigation, the feasibility as well as applicability of an integrated renewable energy system have been approved. It turned out that the energy transition is feasible and most cost-effective, when different mature technologies are combined with an appropriately sized storage and backup system.

  20. Renewable energy for new millennium. Training by multimedia systems; Energias renovables para el nuevo milenio. Ensenanza a traves de sistemas multimedia

    Energy Technology Data Exchange (ETDEWEB)

    Colmenar, A.; Peire, J.; Castro, M.

    2004-07-01

    The aim of this article is to present the multimedia application RENEC (Renewable Energies for the New Century). Its teaching basis, the content, are the Renewable Energies, reinforced by powerful support to the information offered by current multimedia systems, the container. It's about a research project and the development of a multimedia product that tries to bring the knowledge of renewable energies to the society in the most simple, rigorous and pleasant way. (Author)

  1. Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling.

    Science.gov (United States)

    Al-Wadei, Mohammed H; Banerjee, Jheelam; Al-Wadei, Hussein A N; Schuller, Hildegard M

    2016-01-01

    A small subpopulation of pancreatic cancer cells with characteristics of stem cells drive tumour initiation, progression and metastasis. A better understanding of the regulation of cancer stem cells may lead to more effective cancer prevention and therapy. We have shown that the proliferation and migration of pancreatic cancer cell lines is activated by the nicotinic receptor-mediated release of stress neurotransmitters, responses reversed by γ-aminobutyric acid (GABA). However, the observed cancer inhibiting effects of GABA will only succeed clinically if GABA inhibits pancreatic cancer stem cells (PCSCs) in addition to the more differentiated cancer cells that comprise the majority of cancer tissues and cell lines. Using PCSCs isolated from two pancreatic cancer patients by cell sorting and by spheroid formation assay from pancreatic cancer cell line Panc-1, we tested the hypothesis that nicotine induces the self-renewal of PCSCs. Nicotinic acetylcholine receptors (nAChRs) α3, α4, α5 and α7 were expressed and chronic exposure to nicotine increased the protein expression of these receptors. Immunoassays showed that PCSCs produced the stress neurotransmitters epinephrine and norepinephrine and the inhibitory neurotransmitter GABA. Chronic nicotine significantly increased the production of stress neurotransmitters and sonic hedgehog (SHH) while inducing Gli1 protein and decreasing GABA. GABA treatment inhibited the induction of SHH and Gli1. Spheroid formation and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide assays showed significant nicotine-induced increases in self renewal and cell proliferation, responses blocked by GABA. Our data suggest that nicotine increases the SHH-mediated malignant potential of PCSCs and that GABA prevents these effects.

  2. Integration of Renewable Energy Sources in Future Power Systems: The Role of Storage

    CERN Document Server

    Weitemeyer, Stefan; Vogt, Thomas; Agert, Carsten

    2014-01-01

    Integrating a high share of electricity from non-dispatchable Renewable Energy Sources in a power supply system is a challenging task. One option considered in many studies dealing with prospective power systems is the installation of storage devices to balance the fluctuations in power production. However, it is not yet clear how soon storage devices will be needed and how the integration process depends on different storage parameters. Using long-term solar and wind energy power production data series, we present a modelling approach to investigate the influence of storage size and efficiency on the pathway towards a 100% RES scenario. Applying our approach to data for Germany, we found that up to 50% of the overall electricity demand can be met by an optimum combination of wind and solar resources without both curtailment and storage devices if the remaining energy is provided by sufficiently flexible power plants. Our findings show further that the installation of small, but highly efficient storage devic...

  3. SPATIOTEMPORAL MODELING FOR ASSESSING COMPLEMENTARITY OF RENEWABLE ENERGY SOURCES IN DISTRIBUTED ENERGY SYSTEMS

    Directory of Open Access Journals (Sweden)

    L. Ramirez Camargo

    2015-07-01

    Full Text Available Spatial assessments of the potential of renewable energy sources (RES have become a valuable information basis for policy and decision-making. These studies, however, do not explicitly consider the variability in time of RES such as solar energy or wind. Until now, the focus is usually given to economic profitability based on yearly balances, which do not allow a comprehensive examination of RES-technologies complementarity. Incrementing temporal resolution of energy output estimation will permit to plan the aggregation of a diverse pool of RES plants i.e., to conceive a system as a virtual power plant (VPP. This paper presents a spatiotemporal analysis methodology to estimate RES potential of municipalities. The methodology relies on a combination of open source geographic information systems (GIS processing tools and the in-memory array processing environment of Python and NumPy. Beyond the typical identification of suitable locations to build power plants, it is possible to define which of them are the best for a balanced local energy supply. A case study of a municipality, using spatial data with one square meter resolution and one hour temporal resolution, shows strong complementarity of photovoltaic and wind power. Furthermore, it is shown that a detailed deployment strategy of potential suitable locations for RES, calculated with modest computational requirements, can support municipalities to develop VPPs and improve security of supply.

  4. Integrating renewable energy resources with energy storage for grid-connected systems

    Science.gov (United States)

    Carr, Joseph

    Renewable energy resources have been growing at a rapidly accelerating rate as an alternative for fossil fuels in the modern electric grid. As their penetration increases, variability in these resources, particularly wind and solar, poses a risk of instability on the grid. Energy storage can be used to mitigate this risk as well as provide other benefits to the larger grid. In this dissertation, a novel high frequency common bus multiport converter is proposed as a new integration scheme to improve efficiency of the power electronics interface by reducing the number of conversion steps and to reduce the system size by replacing the line frequency transformer with a high frequency transformer tied to the common bus. Two main innovations are introduced: a new switching scheme for the H-bridges on the common bus which allows them to operate in parallel without interfering in each others operation, and a novel single-phase to three-phase matrix converter which converts the high frequency bus to the line frequency in a single conversion stage. This proposed converter is simulated to develop the inner loop control methodology, then a low power prototype is constructed and tested to verify its operation. The results of these tests demonstrate the feasibility of the proposed ideas as well as suggesting new avenues of research to further improve the proposed system.

  5. Spatiotemporal Modeling for Assessing Complementarity of Renewable Energy Sources in Distributed Energy Systems

    Science.gov (United States)

    Ramirez Camargo, L.; Zink, R.; Dorner, W.

    2015-07-01

    Spatial assessments of the potential of renewable energy sources (RES) have become a valuable information basis for policy and decision-making. These studies, however, do not explicitly consider the variability in time of RES such as solar energy or wind. Until now, the focus is usually given to economic profitability based on yearly balances, which do not allow a comprehensive examination of RES-technologies complementarity. Incrementing temporal resolution of energy output estimation will permit to plan the aggregation of a diverse pool of RES plants i.e., to conceive a system as a virtual power plant (VPP). This paper presents a spatiotemporal analysis methodology to estimate RES potential of municipalities. The methodology relies on a combination of open source geographic information systems (GIS) processing tools and the in-memory array processing environment of Python and NumPy. Beyond the typical identification of suitable locations to build power plants, it is possible to define which of them are the best for a balanced local energy supply. A case study of a municipality, using spatial data with one square meter resolution and one hour temporal resolution, shows strong complementarity of photovoltaic and wind power. Furthermore, it is shown that a detailed deployment strategy of potential suitable locations for RES, calculated with modest computational requirements, can support municipalities to develop VPPs and improve security of supply.

  6. The Establishment of a Formal Midwest Renewable Energy Tracking System (M-RETS) Organization

    Energy Technology Data Exchange (ETDEWEB)

    Maria Redmond; Chela Bordas O' Connor

    2010-06-30

    The objectives identified in requesting and utilizing this funding has been met. The goal was to establish a formal, multi-jurisdictional organization to: (1) ensure the policy objectives of the participating jurisdictions are addressed through increased tradability of the Renewable Energy Credits (RECs) from M-RETS and to eliminate the possibility that a single jurisdiction will be the sole arbiter of the operation of the system; (2) facilitate the establishment of REC standards including the attributes related to, the creation, trading, and interaction with other trading and tracking systems; and (3) have a centralized and established organization that will be responsible for the contracting and governance responsibilities of a multi-jurisdictional tracking system. The M-RETS Inc. Board ensures that the system remains policy neutral; that the attributes of generation are tracked in a way that allows the system users to easily identify and trade relevant RECs; that the system can add jurisdictions as needed or desired; and that the tracking system operate in such a way to allow for the greatest access possible for those participating in other tracking or trading systems by allowing those systems to negotiate with a single M-RETS entity for the import and export of RECs. M-RETS as an organizational body participates and often leads the discussions related to the standardization of RECs and increasing the tradability of M-RETS RECs. M-RETS is a founding member of the Environmental Trading Network of North America (ETNNA) and continues to take a leadership role in the development of processes to facilitate trading among tracking systems and to standardize REC definitions. The Board of Directors of M-RETS, Inc., the non-profit corporation, continues to hold telephone/internet Board meetings. Legal counsel continues working with the board and APX management on a new agreement with APX. The board expects to have an agreement and corresponding fee structure in place by

  7. Greenhouse gas emissions of an agro-biogas energy system: Estimation under the Renewable Energy Directive

    Energy Technology Data Exchange (ETDEWEB)

    Rana, Roberto, E-mail: roberto.rana@unifg.it; Ingrao, Carlo; Lombardi, Mariarosaria; Tricase, Caterina

    2016-04-15

    Agro-biogas from energy crops and by-products is a renewable energy carrier that can potentially contribute to climate change mitigation. In this context, application of the methodology defined by the Renewable Energy Directive 2009/28/EC (RED) was performed in order to estimate the 100-year Global Warming Potential (GWP{sub 100}) associated with an agro-biogas supply chain (SC) in Southern Italy. Doing so enabled calculation of Greenhouse Gas (GHG) emission saving in order to verify if it is at least equal to 35% compared to the fossil fuel reference system, as specified by the RED. For the assessment, an attributional Life Cycle Assessment (LCA) approach (International Organization for Standardization (ISO), 2006a,b) was integrated with the RED methodology applied following the guidelines reported in COM(2010)11 and updated by SWD(2014)259 and Report EUR 27215 EN (2015). Moreover, primary data were collected with secondary data extrapolated from the Ecoinvent database system. Results showed that the GWP{sub 100} associated with electricity production through the biogas plant investigated was equal to 111.58 g CO{sub 2eq} MJ{sub e}{sup −1} and so a 40.01% GHG-emission saving was recorded compared to the RED reference. The highest contribution comes from biomass production and, in particular, from crop cultivation due to production of ammonium nitrate in the overall amount used for crop cultivation. Based upon the findings of the study, the GHG saving calculated slightly exceeds the related minimum proposed by the RED: therefore, improvements are needed anyway. In particular, the authors documented that through replacement of ammonium nitrate with urea the GHG-emission saving would increase to almost 68%, thus largely satisfying the RED limit. In addition, the study highlighted that conservation practices, such as NT, can significantly enable reduction of the GHG-emissions coming from agricultural activities. Therefore, those practices should be increasingly

  8. Greenhouse gas emissions of an agro-biogas energy system: Estimation under the Renewable Energy Directive.

    Science.gov (United States)

    Rana, Roberto; Ingrao, Carlo; Lombardi, Mariarosaria; Tricase, Caterina

    2016-04-15

    Agro-biogas from energy crops and by-products is a renewable energy carrier that can potentially contribute to climate change mitigation. In this context, application of the methodology defined by the Renewable Energy Directive 2009/28/EC (RED) was performed in order to estimate the 100-year Global Warming Potential (GWP100) associated with an agro-biogas supply chain (SC) in Southern Italy. Doing so enabled calculation of Greenhouse Gas (GHG) emission saving in order to verify if it is at least equal to 35% compared to the fossil fuel reference system, as specified by the RED. For the assessment, an attributional Life Cycle Assessment (LCA) approach (International Organization for Standardization (ISO), 2006a,b) was integrated with the RED methodology applied following the guidelines reported in COM(2010)11 and updated by SWD(2014)259 and Report EUR 27215 EN (2015). Moreover, primary data were collected with secondary data extrapolated from the Ecoinvent database system. Results showed that the GWP100 associated with electricity production through the biogas plant investigated was equal to 111.58gCO2eqMJe(-1) and so a 40.01% GHG-emission saving was recorded compared to the RED reference. The highest contribution comes from biomass production and, in particular, from crop cultivation due to production of ammonium nitrate in the overall amount used for crop cultivation. Based upon the findings of the study, the GHG saving calculated slightly exceeds the related minimum proposed by the RED: therefore, improvements are needed anyway. In particular, the authors documented that through replacement of ammonium nitrate with urea the GHG-emission saving would increase to almost 68%, thus largely satisfying the RED limit. In addition, the study highlighted that conservation practices, such as NT, can significantly enable reduction of the GHG-emissions coming from agricultural activities. Therefore, those practices should be increasingly adopted for cultivation of energy

  9. Renewable rural electrification. Sustainability assessment of mini-hybrid off-grid technological systems in the African context

    Energy Technology Data Exchange (ETDEWEB)

    Brent, Alan Colin [Resource Based Sustainable Development, Natural Resources and the Environment, CSIR, Stellenbosch (South Africa); Graduate School of Technology Management, University of Pretoria (South Africa); Rogers, David E. [Energy and Processes, Material Science and Manufacturing, CSIR, Pretoria (South Africa)

    2010-01-15

    The investigation summarised in this paper applied a sustainability assessment methodology on a renewable energy technological system in a rural village project that was commissioned by the South African Department of Minerals and Energy. The project comprised of wind, solar and lead-acid battery energy storage technologies that were implemented as a mini-hybrid off-grid electrification system for the village. The sustainability assessment methodology predicts the outcomes of such interventions by way of a learning model using discipline experts in the fields of economics, sociology, ecosystem sustainability, institutional governance, and the physics and chemistry of energy conversion processes. The comparison of the project's outcomes with a South African sustainable development framework shows that the specific village renewable off-grid electrification system is not viable. The main reason is that charges for electricity supply costs in village grids are too high for available subsidies; the economies of scale for renewable energy supply technologies favour national grids. The failure of the integrated system may also be attributable to the complexity of the social-institutional sub-system, which resulted in uncertainty for project planners and system designers, and the lack of resilience of the technological system to demands from the socio-economic and institutional sub-systems. Policy-related recommendations are made accordingly. (author)

  10. Emerging Technologies for the Production of Renewable Liquid Transport Fuels from Biomass Sources Enriched in Plant Cell Walls

    Directory of Open Access Journals (Sweden)

    Hwei-Ting Tan

    2016-12-01

    Full Text Available Plant cell walls are composed predominantly of cellulose, a range of non-cellulosic polysaccharides and lignin. The walls account for a large proportion not only of crop residues such as wheat straw and sugarcane bagasse, but also of residues of the timber industry and specialist grasses and other plants being grown specifically for biofuel production. The polysaccharide components of plant cell walls have long been recognized as an extraordinarily large source of fermentable sugars that might be used for the production of bioethanol and other renewable liquid transport fuels. Estimates place annual plant cellulose production from captured light energy in the order of hundreds of billions of tonnes. Lignin is synthesised in the same order of magnitude and, as a very large polymer of phenylpropanoid residues, lignin is also an abundant, high energy macromolecule. However, one of the major functions of these cell wall constituents in plants is to provide the extreme tensile and compressive strengths that enable plants to resist the forces of gravity and a broad range of other mechanical forces. Over millions of years these wall constituents have evolved under natural selection to generate extremely tough and resilient biomaterials. The rapid degradation of these tough cell wall composites to fermentable sugars is therefore a difficult task and has significantly slowed the development of a viable lignocellulose-based biofuels industry. However, good progress has been made in overcoming this so-called recalcitrance of lignocellulosic feedstocks for the biofuels industry, through modifications to the lignocellulose itself, innovative pre-treatments of the biomass, improved enzymes and the development of superior yeasts and other microorganisms for the fermentation process. Nevertheless, it has been argued that bioethanol might not be the best or only biofuel that can be generated from lignocellulosic biomass sources and that hydrocarbons with

  11. Efficient integration of renewable energy into future energy systems. Development of European energy infrastructures in the period 2030 to 2050

    Energy Technology Data Exchange (ETDEWEB)

    Funk, Carolin; Uhlig, Jeanette; Zoch, Immo (eds.)

    2011-10-15

    In consideration of strategic climate mitigation, energy security and economic competitiveness goals, the EU passed the Directive 2009/28/EC, including a binding target of 20 per cent renewable energy consumption in the EU by 2020. This target is comprehensive and includes energy generation, transport, heating and cooling sectors. In 2008, renewable energy consumption in the EU was about 10 per cent. So meeting the 20 per cent renewable energy objective will require massive changes in energy production, transmission and consumption in the EU. Furthermore, it is obvious that the development of the energy system will not stop in 2020, but that it will continue towards 2050 and beyond. Over the past century, the European electricity system was developed in line with a national utilit y perspective which heavily emphasised large, centralised conventional power production. Investment decisions for new energy infrastructure and technology were typically made at the national level. In the future, much more energy production will be based on local or regional renewable energy sources (RES). Many consumers may also become energy producers feeding into the infrastructures. Transnational energy transfers will gain in importance. These changes will require very different electricity and gas infrastructures and decision-making processes from today. Lack of infrastructure capacity is already a barrier for the further deployment of RES-based energy production in some regions in Europe. (orig.)

  12. Use, operation and maintenance of renewable energy systems experiences and future approaches

    CERN Document Server

    Sanz Bobi, Miguel

    2014-01-01

    Fully accounting for their integration with the current electricity market, and dealing too with emerging uses of energy, this book is fully informed by real-life experiences that provide varying perspectives on the efficiency of renewable energy production.

  13. Intelligent Photovoltaic Maximum Power Point Tracking Controller for Energy Enhancement in Renewable Energy System

    Directory of Open Access Journals (Sweden)

    Subiyanto

    2013-01-01

    Full Text Available Photovoltaic (PV system is one of the promising renewable energy technologies. Although the energy conversion efficiency of the system is still low, but it has the advantage that the operating cost is free, very low maintenance and pollution-free. Maximum power point tracking (MPPT is a significant part of PV systems. This paper presents a novel intelligent MPPT controller for PV systems. For the MPPT algorithm, an optimized fuzzy logic controller (FLC using the Hopfield neural network is proposed. It utilizes an automatically tuned FLC membership function instead of the trial-and-error approach. The MPPT algorithm is implemented in a new variant of coupled inductor soft switching boost converter with high voltage gain to increase the converter output from the PV panel. The applied switching technique, which includes passive and active regenerative snubber circuits, reduces the insulated gate bipolar transistor switching losses. The proposed MPPT algorithm is implemented using the dSPACE DS1104 platform software on a DS1104 board controller. The prototype MPPT controller is tested using an agilent solar array simulator together with a 3 kW real PV panel. Experimental test results show that the proposed boost converter produces higher output voltages and gives better efficiency (90% than the conventional boost converter with an RCD snubber, which gives 81% efficiency. The prototype MPPT controller is also found to be capable of tracking power from the 3 kW PV array about 2.4 times more than that without using the MPPT controller.

  14. Strategies for optimal penetration of intermittent renewables in complex energy systems based on techno-operational objectives

    Energy Technology Data Exchange (ETDEWEB)

    Franco, Alessandro; Salza, Pasquale [Dipartimento di Energetica ' ' L. Poggi' ' , Universita di Pisa, Largo Lucio Lazzarino, 2, 56126 PISA (Italy)

    2011-02-15

    Renewable energy sources (RES) are mainly used in the electrical sector. Electricity is not a storable commodity. Hence it is necessary to produce the requested quantity and distribute it through the system in such a way as to ensure that electricity supply and demand are always evenly balanced. This constraint is actually the main problem related to the penetration of new renewables (wind and photovoltaic power) in the context of complex energy systems. Moreover the design of optimal energy resource mixes in climate change mitigation actions is a challenge faced in many places. The paper analyzes the problem of new renewable energy sources penetration. The case of Italian scenario is considered as a meaningful reference due to the characteristic size and the complexity of the same. The various energy scenarios are evaluated with the aid of a multipurpose software taking into account the interconnections between the different energetic uses. In particular it is shown how the penetration of new renewable energy sources is limited at an upper level by technological considerations and it will be more sustainable if an integration of the various energy uses (thermal, mobility and electrical) will be considered. A series of optimized scenarios are developed. In each case the maximum RES penetration feasible with the constraints was defined. Then analysis is applied to an energy system model of Italy showing how an integrated development of CHP and electric mobility can aid a further integration of wind and photovoltaic energy power. Finally the primary energy consumption saving possible in case of consistent penetration of intermittent renewables and CHP was identified. (author)

  15. TiO2 Nanostructure Synthesized by Sol-Gel for Dye Sensitized Solar Cells as Renewable Energy Source

    Science.gov (United States)

    Ramelan, A. H.; Wahyuningsih, S.; Saputro, S.; Supriyanto, E.; Hanif, Q. A.

    2017-02-01

    The use of renewable materials as a constituent of a smart alternative energy such as the use of natural dyes for light harvesting needs to be developed. Synthesis of anatase titanium dioxide (TiO2) and fabrication Dye-Sensitized Solar Cell (DSSC) using dye-based of anthocyanin from purple sweet potato (Ipomoea batatas L.) as a photosensitizer had been done. Synthesis TiO2 through sol-gel process with the addition of triblock copolymer Pluronic F127 template was controlled at pH 3 whereas calcination was carried out at a temperature of 500 °C, 550 °C and 600 °C. The obtained TiO2 were analyzed by XRD, SAA, and SEM. The conclusion is anatase TiO2 obtained until annealing up to 600 °C. Self-assembly Pluronic F127 triblock copolymer capable of restraining the growth of TiO2 crystals. Retention growth of TiO2 mesoporous produces material character that can be used as builders photoanode DSSC with natural sensitizer anthocyanin from purple sweet potatoes. Based on the analysis of X-ray diffraction patterns and surface area analyser, the higher the calcination temperature the greater the size of the anatase crystals is obtained, however, the smaller its surface area. Purple sweet potato anthocyanin’s dyed on to TiO2 was obtained a good enough performance for DSSC’s and gain the optimum performance from DSSC’s system built with mesoporous TiO2 annealed 550 °C using flavylium form anthocyanin.

  16. Dynamic analyses of regenerative fuel cell power for potential use in renewable residential applications

    OpenAIRE

    Maclay, JD; J. Brouwer; Samuelsen, GS

    2006-01-01

    A model of a solar-hydrogen powered residence, in both stand-alone and grid parallel configurations, was developed using Matlab / Simulink®. The model assesses the viability of employing a regenerative fuel cell (RFC) as an energy storage device to be used with photovoltaic (PV) electrical generation. Other modes of energy storage such as batteries and hybrid storage were also evaluated. Analyses of various operating conditions, system configurations, and control strategies were performed. De...

  17. Systems cell biology.

    Science.gov (United States)

    Mast, Fred D; Ratushny, Alexander V; Aitchison, John D

    2014-09-15

    Systems cell biology melds high-throughput experimentation with quantitative analysis and modeling to understand many critical processes that contribute to cellular organization and dynamics. Recently, there have been several advances in technology and in the application of modeling approaches that enable the exploration of the dynamic properties of cells. Merging technology and computation offers an opportunity to objectively address unsolved cellular mechanisms, and has revealed emergent properties and helped to gain a more comprehensive and fundamental understanding of cell biology.

  18. Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.

    Directory of Open Access Journals (Sweden)

    Daniela M Santos

    Full Text Available Calpains are calcium regulated cysteine proteases that have been described in a wide range of cellular processes, including apoptosis, migration and cell cycle regulation. In addition, calpains have been implicated in differentiation, but their impact on neural differentiation requires further investigation. Here, we addressed the role of calpain 1 and calpain 2 in neural stem cell (NSC self-renewal and differentiation. We found that calpain inhibition using either the chemical inhibitor calpeptin or the endogenous calpain inhibitor calpastatin favored differentiation of NSCs. This effect was associated with significant changes in cell cycle-related proteins and may be regulated by calcium. Interestingly, calpain 1 and calpain 2 were found to play distinct roles in NSC fate decision. Calpain 1 expression levels were higher in self-renewing NSC and decreased with differentiation, while calpain 2 increased throughout differentiation. In addition, calpain 1 silencing resulted in increased levels of both neuronal and glial markers, β-III Tubulin and glial fibrillary acidic protein (GFAP. Calpain 2 silencing elicited decreased levels of GFAP. These results support a role for calpain 1 in repressing differentiation, thus maintaining a proliferative NSC pool, and suggest that calpain 2 is involved in glial differentiation.

  19. TGF-β inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors.

    Science.gov (United States)

    Gao, Xiaofei; Lee, Hsiang-Ying; da Rocha, Edroaldo Lummertz; Zhang, Cheng; Lu, Yi-Fen; Li, Dandan; Feng, Yuxiong; Ezike, Jideofor; Elmes, Russell R; Barrasa, M Inmaculada; Cahan, Patrick; Li, Hu; Daley, George Q; Lodish, Harvey F

    2016-12-08

    Burst-forming unit erythroid progenitors (BFU-Es) are so named based on their ability to generate in methylcellulose culture large colonies of erythroid cells that consist of "bursts" of smaller erythroid colonies derived from the later colony-forming unit erythroid progenitor erythropoietin (Epo)-dependent progenitors. "Early" BFU-E cells forming large BFU-E colonies presumably have higher capacities for self-renewal than do "late" BFU-Es forming small colonies, but the mechanism underlying this heterogeneity remains unknown. We show that the type III transforming growth factor β (TGF-β) receptor (TβRIII) is a marker that distinguishes early and late BFU-Es. Transient elevation of TβRIII expression promotes TGF-β signaling during the early BFU-E to late BFU-E transition. Blocking TGF-β signaling using a receptor kinase inhibitor increases early BFU-E cell self-renewal and total erythroblast production, suggesting the usefulness of this type of drug in treating Epo-unresponsive anemias.

  20. The homeobox gene Gsx2 regulates the self-renewal and differentiation of neural stem cells and the cell fate of postnatal progenitors.

    Directory of Open Access Journals (Sweden)

    Héctor R Méndez-Gómez

    Full Text Available The Genetic screened homeobox 2 (Gsx2 transcription factor is required for the development of olfactory bulb (OB and striatal neurons, and for the regional specification of the embryonic telencephalon. Although Gsx2 is expressed abundantly by progenitor cells in the ventral telencephalon, its precise function in the generation of neurons from neural stem cells (NSCs is not clear. Similarly, the role of Gsx2 in regulating the self-renewal and multipotentiality of NSCs has been little explored. Using retroviral vectors to express Gsx2, we have studied the effect of Gsx2 on the growth of NSCs isolated from the OB and ganglionic eminences (GE, as well as its influence on the proliferation and cell fate of progenitors in the postnatal mouse OB. Expression of Gsx2 reduces proliferation and the self-renewal capacity of NSCs, without significantly affecting cell death. Furthermore, Gsx2 overexpression decreases the differentiation of NSCs into neurons and glia, and it maintains the cells that do not differentiate as cycling progenitors. These effects were stronger in GESCs than in OBSCs, indicating that the actions of Gsx2 are cell-dependent. In vivo, Gsx2 produces a decrease in the number of Pax6+ cells and doublecortin+ neuroblasts, and an increase in Olig2+ cells. In summary, our findings show that Gsx2 inhibits the ability of NSCs to proliferate and self-renew, as well as the capacity of NSC-derived progenitors to differentiate, suggesting that this transcription factor regulates the quiescent and undifferentiated state of NSCs and progenitors. Furthermore, our data indicate that Gsx2 negatively regulates neurogenesis from postnatal progenitor cells.

  1. Test of the hypothesis; a lymphoma stem cells exist which is capable of self-renewal

    DEFF Research Database (Denmark)

    Kjeldsen, Malene Krag

      Test of the hypothesis; a lymphoma stem cell exist which is capable of self-renewal   Malene Krag Pedersen, Karen Dybkaer, Hans E. Johnsen   The Research Laboratory, Department of Haematology, Aalborg Hospital, Århus University   Failure of current therapeutics in the treatment of diffuse large B...... and sustaining cells(1-3). My project is based on studies of stem and early progenitor cells in lymphoid cell lines from patients with advanced DLBCL. The cell lines are world wide recognised and generously provided by Dr. Hans Messner and colleagues.   Hypothesis and aims: A lymphoma stem and progenitor cell......RT-PCR.          (1)    Bonnet D. Normal and leukaemic stem cells. Br J Haematol 2005 Aug;130(4):469-79.        (2)    Huntly BJ, Gilliland DG. Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer 2005 Apr;5(4):311-21.        (3)    Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem...

  2. Building a sustainable market for renewables

    Energy Technology Data Exchange (ETDEWEB)

    Rader, N.

    1996-12-31

    Opinions regarding marketing approaches for electricity generation from renewable resources are presented in the paper. The Renewables Portfolio Standard of the California Public Utilities Commission is described. This system is based on renewable energy credits. Other marketing approaches, including surcharges, auctioned renewables credit, green pricing, and green marketing are also assessed. It is concluded that the Renewables Portfolio Standard creates a stable economic environment for the renewable energy industries.

  3. On the Acceptance and Sustainability of Renewable Energy Projects—A Systems Thinking Perspective

    Directory of Open Access Journals (Sweden)

    Ana María González

    2016-11-01

    Full Text Available Rapid population growth and increasing concern related to improving the living standards in impoverished communities without damaging the natural environment have drawn attention to the adoption of renewable energy systems (RES around the world. Despite this global trend, the implementation of these projects has not succeeded completely in rural poor communities due to several factors, including social barriers faced at the time of their execution. These social barriers lead to poor acceptance of the projects and their consequent abandonment. Acceptance is a social construct that is influenced by several factors that need to be understood to achieve successful and sustainable results in the future. In this paper, we develop a conceptual model, based on principles of sustainability and systems thinking, to understand the interrelationships among the main factors that have been reported in the literature as key to determining the sustainability and community acceptance of RES projects. To do so, we review the existing literature on sustainability and social acceptance of RES and then construct a causal-loop diagram of their driving factors. While doing so, we also view the problem through the lens of the sustainable livelihoods framework, aiming to maintain the perspective of rural communities and observing the impacts of RES on their contextual reality. The resulting model helps to understand the multiple interactions that RES projects have with rural communities as well as identify potential intervention points for future projects. We end the paper with a discussion of the implications of the model and how can it be used to inform future rural energy decision making.

  4. Electrochemical storage systems for renewable power supply systems. Workshop; Elektrochemische Speichersysteme fuer regenerative Energieversorgungsanlagen. Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Garche, J.; Hoehe, W. [Zentrum fuer Sonnenenergie- und Wasserstoff-Forschung Baden-Wuerttemberg (ZSW), Ulm (Germany); Stadermann, G. [eds.] [Forschungsverbund Sonnenenergie, Berlin (Germany)

    1999-07-01

    This volume contains 26 contributions on batteries and PV systems. Vol. 1 discusses the following subjects: 1. Evaluation and assessment of the performance of battery systems in existing PV systems; 2. Status and prospects of storage systems; 3. Experience, requirements and markets; 4. Storage battery operation and assessment; 5. Systems engineering and operation of PV systems. [German] Dieser Band enthaelt 26 Beitraege zum aktuellen Stand der Batterien sowie der dazugehoerigen Systeme fuer Photovoltaik-Anlagen. Der Band ist in fuenf Themenbereiche unterteilt: 1. Auswertung und Bewertung des Betriebsverhaltens von Batteriesystemen in bestehenden PV-Anlagen; 2. Stand und Zukunft von Speichersystemen; 3.Erfahrungen, Anforderungen und Maerkte; 4. Speicher-Betriebsfuehrung und -Zustandsbestimmung; und 5. Systemtechnik und Betriebsfuehrung von PV-Systemen.

  5. AICAR Sustains J1 Mouse Embryonic Stem Cell Self-Renewal and Pluripotency by Regulating Transcription Factor and Epigenetic Modulator Expression

    Directory of Open Access Journals (Sweden)

    Xiaoyan Shi

    2013-08-01

    Full Text Available Backgroud/Aims: Embryonic stem cells (ES cells have the capacity to propagate indefinitely, maintain pluripotency, and differentiate into any cell type under defined conditions. As a result, they are considered to be the best model system for research into early embryonic development. AICA ribonucleotide (AICAR is an activator of AMP-activated protein kinase (AMPK that is thought to affect ES cell function, but its role in ES cell fate decision is unclear. Methods: In this study, we performed microarray analysis to investigate AICAR downstream targets and further understand its effect on ES cells. Results: Our microarray data demonstrated that AICAR can significantly up-regulate pluripotency-associated genes and down-regulate differentiation-associated transcription factors. Although AICAR cannot maintain ES cell identity without LIF, it can antagonize the action of RA-induced differentiation. Using those differentially expressed genes identified, we performed gene ontology (GO and Kyoto Encyclopedia of Genes and Genomes (KEGG pathway analysis with the Database for Annotation, Visualization and Integrated Discovery (DAVID online system. AICAR was not only shown to influence the AMPK pathway, but also act on other signaling pathways such as BMP, MAPK and TGF-β, to maintain the stemness of J1 ES cells. Furthermore, AICAR modulated ES cell epigenetic modification by altering the expression of epigenetic-associated proteins, including Dnmt3a, Dnmt3b, Smarca2, Mbd3, and Arid1a, or through regulating the transcription of long intervening non-coding RNA (lincRNA. Conclusion: Taken together, our work suggests that AICAR is capable of maintaining ES cell self-renewal and pluripotency, which could be useful in future medical treatment.

  6. A Hybrid RenewableEnergy System (Wind and Solar) Size Optimization and Costing for Residential Buildings in Urban Armidale NSW, Australia

    OpenAIRE

    Yasser Maklad

    2014-01-01

    This paper discusses and determines the optimization process of sizing a hybrid renewable energy system designed for urban residential buildings in Armidale NSW, Australia. The considered renewable energy system comprises of solar photovoltaic (PV) system and wind turbines as small scale or microscale, thus it is a green sustainable system compared with already existing in use conventional traditional electricity generation based on fossil fuel, mainly coal burning which is definitely neither...

  7. Modeling Feasibility of a Proposed Renewable Energy System with Wind and Solar Resources and Hydro Storage in Complex Terrain

    Science.gov (United States)

    Jiang, J.; Koracin, D.; Hamilton, R.; Hagen, D.; King, K. C.

    2012-04-01

    High temporal and spatial variability in wind and solar power brings difficulties in integrating these resources into an electricity grid. These difficulties are even more emphasized in areas with complex topography due to complicated flow patterns and cloudiness evolution. This study investigates the feasibility and efficiency of a proposed renewable energy system with wind and solar resources and hydro storages in western Nevada, U.S.A. The state-of-the-art Weather Research and Forecasting (WRF) model was used for the prediction of wind fields and incoming solar radiation at the ground surface. Forecast winds and solar radiation were evaluated with observational data from four wind masts and four meteorological towers in two months, July 2007 and January 2010. Based on a hypothetical wind farm and an assumed neighboring solar power plant both located near the hydro storage facility, as well as considering local power demand, the efficiency of the renewable energy system is projected. One of the main questions was how to optimize a schedule of activating pump storages according to the characteristics of several available hydro pumps, and wind and/or solar power predictions. The results show that segmentation of the pump-storage channel provides improved efficiency of the entire system. This modeled renewable energy system shows promise for possible applications and grid integration.

  8. Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

    Science.gov (United States)

    Corominas-Faja, Bruna; Cuyàs, Elisabet; Gumuzio, Juan; Bosch-Barrera, Joaquim; Leis, Olatz; Martin, Ángel G.; Menendez, Javier A.

    2014-01-01

    Cancer stem cells (CSC) may take advantage of the Warburg effect-induced siphoning of metabolic intermediates into de novo fatty acid biosynthesis to increase self-renewal growth. We examined the anti-CSC effects of the antifungal polyketide soraphen A, a specific inhibitor of the first committed step of lipid biosynthesis catalyzed by acetyl-CoA carboxylase (ACACA). The mammosphere formation capability of MCF-7 cells was reduced following treatment with soraphen A in a dose-dependent manner. MCF-7 cells engineered to overexpress the oncogene HER2 (MCF-7/HER2 cells) were 5-fold more sensitive than MCF-7 parental cells to soraphen A-induced reductions in mammosphere-forming efficiency. Soraphen A treatment notably decreased aldehyde dehydrogenase (ALDH)-positive CSC-like cells and impeded the HER2's ability to increase the ALDH+-stem cell population. The following results confirmed that soraphen A-induced suppression of CSC populations occurred through ACACA-driven lipogenesis: a.) exogenous supplementation with supraphysiological concentrations of oleic acid fully rescued mammosphere formation in the presence of soraphen A and b.) mammosphere cultures of MCF-7 cells with stably silenced expression of the cytosolic isoform ACACA1, which specifically participates in de novo lipogenesis, were mostly refractory to soraphen A treatment. Our findings reveal for the first time that ACACA may constitute a previously unrecognized target for novel anti-breast CSC therapies. PMID:25246709

  9. Monitoring and Control by Virtual Tools of an Educational Renewable Energy System

    Directory of Open Access Journals (Sweden)

    Gligor Adrian

    2009-12-01

    Full Text Available The scope of the present paper is to present the architecture and design of an effective tool useful for monitoring, maintenance and training of specialists in the field of photovoltaic renewable energy Among renewable energy resources, solar energy represents an easy to use, accessible and green source of energy. An important goal is the efficient use of solar energy which can only be achieved by the knowledge of solar datum and equipment characteristics from a studied area. Based on this idea, the paper presents a concept of virtual tools developed on web technologies and virtual instrumentation for monitoring and control of solar renewable energy. These tools are mainly designed as a base for a virtual laboratory that can be used for the study of photovoltaic and thermal solar energy parameters, representing, by didactical point of view, a handful way for students to study the phenomenology and also a training tool for specialists in the field of solar photovoltaic energy.

  10. Ethanol Inactivated Mouse Embryonic Fibroblasts Maintain the Self-Renew and Proliferation of Human Embryonic Stem Cells.

    Science.gov (United States)

    Huang, Boxian; Ning, Song; Zhuang, Lili; Jiang, Chunyan; Cui, Yugui; Fan, Guoping; Qin, Lianju; Liu, Jiayin

    2015-01-01

    Conventionally, mouse embryonic fibroblasts (MEFs) inactivated by mitomycin C or irradiation were applied to support the self-renew and proliferation of human embryonic stem cells (hESCs). To avoid the disadvangtages of mitomycin C and irradiation, here MEFs were treated by ethanol (ET). Our data showed that 10% ET-inactivated MEFs (eiMEFs) could well maintain the self-renew and proliferation of hESCs. hESCs grown on eiMEFs expressed stem cell markers of NANOG, octamer-binding protein 4 (OCT4), stage-specific embryonic antigen-4 (SSEA4) and tumour related antigen-1-81 (TRA-1-81), meanwhile maintained normal karyotype after long time culture. Also, hESCs cocultured with eiMEFs were able to form embryoid body (EB) in vitro and develop teratoma in vivo. Moreover, eiMEFs could keep their nutrient functions after long time cryopreservation. Our results indicate that the application of eiMEF in hESCs culture is safe, economical and convenient, thus is a better choice.

  11. The N-terminal domain is a transcriptional activation domain required for Nanog to maintain ES cell self-renewal

    Institute of Scientific and Technical Information of China (English)

    GUO YunQian; ZHANG Juan; YE Li; CHEN Mo; YAO Dong; PAN GuangJin; ZHANG JieQiong; PEI DuanQing

    2009-01-01

    Nanog is a transcription factor identified by its ability to maintain the self-renewal of ES cells in the absence of leukemia inhibitory factor (LIF). Nanog protein contains an N-terminal domain (ND),a DNA-binding homeobox domain (HD) and a C-terminal domain (CD). We previously reported that the CD in Nanog is a transcriptional activation domain essential for the in vivo function of Nanog. Here we demonstrated that the ND in Nanog is also functionally important. Deletion of the ND reduces the transcriptional activity of Nanog on either artificial reporters or native Nanog promoters. This truncated Nanog is also less effective in regulating the endogenous Nanog target genes. Furthermore,the ND truncation disrupted the ability of Nanog to maintain ES cell self-renewal as well. We found that the ND Is not required for the nuclear localization of Nanog. These results suggest that the regulation of endogenous pluripotent genes such as oct3/4 and rex-1 is required for the in vivo function of Nanog.

  12. Inborn Errors of Long-Chain Fatty Acid β-Oxidation Link Neural Stem Cell Self-Renewal to Autism

    Directory of Open Access Journals (Sweden)

    Zhigang Xie

    2016-02-01

    Full Text Available Inborn errors of metabolism (IEMs occur with high incidence in human populations. Especially prevalent among these are inborn deficiencies in fatty acid β-oxidation (FAO, which are clinically associated with developmental neuropsychiatric disorders, including autism. We now report that neural stem cell (NSC-autonomous insufficiencies in the activity of TMLHE (an autism risk factor that supports long-chain FAO by catalyzing carnitine biosynthesis, of CPT1A (an enzyme required for long-chain FAO transport into mitochondria, or of fatty acid mobilization from lipid droplets reduced NSC pools in the mouse embryonic neocortex. Lineage tracing experiments demonstrated that reduced flux through the FAO pathway potentiated NSC symmetric differentiating divisions at the expense of self-renewing stem cell division modes. The collective data reveal a key role for FAO in controlling NSC-to-IPC transition in the mammalian embryonic brain and suggest NSC self renewal as a cellular mechanism underlying the association between IEMs and autism.

  13. Dynamic cell culture system (7-IML-1)

    Science.gov (United States)

    Cogoli, Augusto

    1992-01-01

    This experiment is one of the Biorack experiments being flown on the International Microgravity Laboratory 1 (MIL-1) mission as part of an investigation studying cell proliferation and performance in space. One of the objectives of this investigation is to assess the potential benefits of bioprocessing in space with the ultimate goal of developing a bioreactor for continuous cell cultures in space. This experiment will test the operation of an automated culture chamber that was designed for use in a Bioreactor in space. The device to be tested is called the Dynamic Cell Culture System (DCCS). It is a simple device in which media are renewed or chemicals are injected automatically, by means of osmotic pumps. This experiment uses four Type I/O experiment containers. One DCCS unit, which contains a culture chamber with renewal of medium and a second chamber without a medium supply fits in each container. Two DCCS units are maintained under zero gravity conditions during the on-orbit period. The other two units are maintained under 1 gh conditions in a 1 g centrifuge. The schedule for incubator transfer is given.

  14. EphB4 Regulates Self-Renewal, Proliferation and Neuronal Differentiation of Human Embryonic Neural Stem Cells in Vitro

    Directory of Open Access Journals (Sweden)

    Tingting Liu

    2017-02-01

    Full Text Available Background/Aims: EphB4 belongs to the largest family of Eph receptor tyrosine kinases. It contributes to a variety of pathological progresses of cancer malignancy. However, little is known about its role in neural stem cells (NSCs. This study examined whether EphB4 is required for proliferation and differentiation of human embryonic neural stem cells (hNSCs in vitro. Methods: We up- and down-regulated EphB4 expression in hNSCs using lentiviral over-expression and shRNA knockdown constructs and then investigated the influence of EphB4 on the properties of hNSCs. Results: Our results show that shRNA-mediated EphB4 reduction profoundly impaired hNSCs self-renewal and proliferation. Furthermore, detection of differentiation revealed that knockdown of EphB4 inhibited hNSCs differentiation towards a neuronal lineage and promoted hNSCs differentiation to glial cells. In contrast, EphB4 overexpression promoted hNSCs self-renewal and proliferation, further induced hNSCs differentiation towards a neuronal lineage and inhibited hNSCs differentiation to glial cells. Moreover, we found that EphB4 regulates cell proliferation mediated by the Abl-CyclinD1 pathway. Conclusion: These studies provide strong evidence that fine tuning of EphB4 expression is crucial for the proliferation and neuronal differentiation of hNSCs, suggesting that EphB4 might be an interesting target for overcoming some of the therapeutic limitations of neuronal loss in brain diseases.

  15. The Effect of Electric Load Profiles on the Performance of Off-Grid Residential Hybrid Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    Stephen Treado

    2015-10-01

    Full Text Available This paper investigates the energy performance of off-grid residential hybrid renewable electric power systems, particularly the effect of electric load profiles on the ability to harvest available solar energy and avoid the consumption of auxiliary energy in the form of propane. The concepts are illustrated by an analysis of the energy performance of electric and propane-fired refrigerators. Off-grid electric power systems frequently incorporate a renewable source, such as wind or solar photovoltaic (PV, with a back-up power provided by a propane fueled motor/generator. Among other design decisions, residential consumers face the choice of employing an electric refrigerator with a conventional vapor compression refrigeration system, or a fuel-fired refrigerator operating as an absorption refrigeration system. One interesting question is whether it is more advantageous from an energy perspective to use electricity to run the refrigerator, which might be provided by some combination of the PV and propane motor/generator, thereby taking advantage of the relatively higher electric refrigerator Coefficient of Performance (COP and free solar energy but having to accept a low electrical conversion efficiency of the motor/generator, or use thermal energy from the combustion of propane to produce the refrigeration effect via an absorption system, albeit with a much lower COP. The analysis is complicated by the fact that most off-grid renewable electrical power systems utilize a battery bank to provide electrical power when it is not available from the wind turbine or PV system, so the state of charge of the battery bank will have a noticeable impact on what energy source is available at any moment in time. Daily electric load profiles combined with variable solar energy input determine the state of charge of the battery bank, with the degree of synchronization between the two being a critical factor in determining performance. The annual energy usage

  16. Renewable Substitutability Index: Maximizing Renewable Resource Use in Buildings

    Directory of Open Access Journals (Sweden)

    Ravi S. Srinivasan

    2015-05-01

    Full Text Available In order to achieve a material and energy balance in buildings that is sustainable in the long run, there is an urgent need to assess the renewable and non-renewable resources used in the manufacturing process and to progressively replace non-renewable resources with renewables. Such progressive disinvestment in the non-renewable resources that may be substituted with renewable resources is referred to as “Renewable Substitutability” and if implemented, this process will lead to a paradigm shift in the way building materials are manufactured. This paper discusses the development of a Renewable Substitutability Index (RSI that is designed to maximize the use of renewable resources in a building and quantifies the substitution process using solar emergy (i.e., the solar equivalent joules required for any item. The RSI of a building or a building component, i.e., floor or wall systems, etc., is the ratio of the renewable resources used during construction, including replacement and maintenance, to the building’s maximum renewable emergy potential. RSI values range between 0 and 1.0. A higher RSI achieves a low-energy building strategy promoting a higher order of sustainability by optimizing the use of renewables over a building’s lifetime from formation-extraction-manufacturing to maintenance, operation, demolition, and recycle.

  17. γ-Secretase Inhibitor, DAPT Inhibits Self-renewal and Stemness Maintenance of Ovarian Cancer Stem-like Cells In Vitro

    Institute of Scientific and Technical Information of China (English)

    Li-yu Jiang; Xiao-lei Zhang; Ping Du; Jian-hua Zheng

    2011-01-01

    Objective: The Notch signaling pathway plays an important role in the stem cell signaling network and contributes to tumorigenesis. However, the functions of Notch signaling in ovarian cancer stem cells (OCSCs) are not well understood. We aimed to investigate the effects of Notch blockade on self-renewal and stemness maintenance of OCSCs. Methods: Ovarian cancer stem-like cells were enriched from ovarian cancer cell lines in serum-free medium. A y-secretase inhibitor, (DAPT), was used to block Notch signaling. MTT assays were performed to assess self-renewal and proliferation inhibition, flow cytometry was performed to analyze cell surface marker and immunofluorescence,Western Blot and Real-time RT-PCR assays were performed to detect Oct4 and Sox2 protein and mRNA expression of the Ovarian cancer stem-like cells treated with DAPT. Results: Notch blockade markedly inhibits self-renewal and proliferation of ovarian cancer stem-like cells,significantly downregulates the expression of OCSCs-specific surface markers, and reduces protein and mRNA expression of Oct4 and Sox2 in OCSC-like cells. Conclusion: Our results suggest that Notch signaling is not only critical for the self-renewal and proliferation of OCSCs, but also for the stemness maintenance of OCSCs. The γ-secretase inhibitor is a promising treatment targeting OCSCs.

  18. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.

    Science.gov (United States)

    Guryanova, Olga A; Wu, Qiulian; Cheng, Lin; Lathia, Justin D; Huang, Zhi; Yang, Jinbo; MacSwords, Jennifer; Eyler, Christine E; McLendon, Roger E; Heddleston, John M; Shou, Weinian; Hambardzumyan, Dolores; Lee, Jeongwu; Hjelmeland, Anita B; Sloan, Andrew E; Bredel, Markus; Stark, George R; Rich, Jeremy N; Bao, Shideng

    2011-04-12

    Glioblastomas display cellular hierarchies containing tumor-propagating glioblastoma stem cells (GSCs). STAT3 is a critical signaling node in GSC maintenance but molecular mechanisms underlying STAT3 activation in GSCs are poorly defined. Here we demonstrate that the bone marrow X-linked (BMX) nonreceptor tyrosine kinase activates STAT3 signaling to maintain self-renewal and tumorigenic potential of GSCs. BMX is differentially expressed in GSCs relative to nonstem cancer cells and neural progenitors. BMX knockdown potently inhibited STAT3 activation, expression of GSC transcription factors, and growth of GSC-derived intracranial tumors. Constitutively active STAT3 rescued the effects of BMX downregulation, supporting that BMX signals through STAT3 in GSCs. These data demonstrate that BMX represents a GSC therapeutic target and reinforces the importance of STAT3 signaling in stem-like cancer phenotypes.

  19. Cell Radiation Experiment System

    Science.gov (United States)

    Morrison, Dennis R.

    2010-01-01

    The cell radiation experiment system (CRES) is a perfused-cell culture apparatus, within which cells from humans or other animals can (1) be maintained in homeostasis while (2) being exposed to ionizing radiation during controlled intervals and (3) being monitored to determine the effects of radiation and the repair of radiation damage. The CRES can be used, for example, to determine effects of drug, radiation, and combined drug and radiation treatments on both normal and tumor cells. The CRES can also be used to analyze the effects of radiosensitive or radioprotectant drugs on cells subjected to radiation. The knowledge gained by use of the CRES is expected to contribute to the development of better cancer treatments and of better protection for astronauts, medical-equipment operators, and nuclear-power-plant workers, and others exposed frequently to ionizing radiation.

  20. miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation

    Directory of Open Access Journals (Sweden)

    Hsiao-Ning Huang

    2014-03-01

    Full Text Available Human embryonic stem cells (hESCs are functionally unique for their self-renewal ability and pluripotency, but the molecular mechanisms giving rise to these properties are not fully understood. hESCs can differentiate into embryoid bodies (EBs containing ectoderm, mesoderm, and endoderm. In the miR-200 family, miR-200c was especially enriched in undifferentiated hESCs and significantly downregulated in EBs. The knockdown of the miR-200c in hESCs downregulated Nanog expression, upregulated GATA binding protein 4 (GATA4 expression, and induced hESC apoptosis. The knockdown of GATA4 rescued hESC apoptosis induced by downregulation of miR-200c. miR-200c directly targeted the 3′-untranslated region of GATA4. Interestingly, the downregulation of GATA4 significantly inhibited EB formation in hESCs. Overexpression of miR-200c inhibited EB formation and repressed the expression of ectoderm, endoderm, and mesoderm markers, which could partially be rescued by ectopic expression of GATA4. Fibroblast growth factor (FGF and activin A/nodal can sustain hESC renewal in the absence of feeder layer. Inhibition of transforming growth factor-β (TGF-β/activin A/nodal signaling by SB431542 treatment downregulated the expression of miR-200c. Overexpression of miR-200c partially rescued the expression of Nanog/phospho-Smad2 that was downregulated by SB431542 treatment. Our observations have uncovered novel functions of miR-200c and GATA4 in regulating hESC renewal and differentiation.