WorldWideScience

Sample records for cell product design

  1. MOLTEN CARBONATE FUEL CELL PRODUCT DESIGN IMPROVEMENT

    Energy Technology Data Exchange (ETDEWEB)

    H.C. Maru; M. Farooque

    2003-03-01

    The program efforts are focused on technology and system optimization for cost reduction, commercial design development, and prototype system field trials. The program is designed to advance the carbonate fuel cell technology from full-size field test to the commercial design. FuelCell Energy, Inc. (FCE) is in the later stage of the multiyear program for development and verification of carbonate fuel cell based power plants supported by DOE/NETL with additional funding from DOD/DARPA and the FuelCell Energy team. FCE has scaled up the technology to full-size and developed DFC{reg_sign} stack and balance-of-plant (BOP) equipment technology to meet product requirements, and acquired high rate manufacturing capabilities to reduce cost. FCE has designed submegawatt (DFC300A) and megawatt (DFC1500 and DFC3000) class fuel cell products for commercialization of its DFC{reg_sign} technology. A significant progress was made during the reporting period. The reforming unit design was optimized using a three-dimensional stack simulation model. Thermal and flow uniformities of the oxidant-In flow in the stack module were improved using computational fluid dynamics based flow simulation model. The manufacturing capacity was increased. The submegawatt stack module overall cost was reduced by {approx}30% on a per kW basis. An integrated deoxidizer-prereformer design was tested successfully at submegawatt scale using fuels simulating digester gas, coal bed methane gas and peak shave (natural) gas.

  2. Direct fuel cell product design improvement

    Energy Technology Data Exchange (ETDEWEB)

    Maru, H.C.; Farooque, M. [Energy Research Corp., Danbury, CT (United States)

    1996-12-31

    Significant milestones have been attained towards the technology development field testing and commercialization of direct fuel cell power plant since the 1994 Fuel Cell Seminar. Under a 5-year cooperative agreement with the Department of Energy signed in December 1994, Energy Research Corporation (ERC) has been developing the design for a MW-scale direct fuel cell power plant with input from previous technology efforts and the Santa Clara Demonstration Project. The effort encompasses product definition in consultation with the Fuel Cell Commercialization Group, potential customers, as well as extensive system design and packaging. Manufacturing process improvements, test facility construction, cell component scale up, performance and endurance improvements, stack engineering, and critical balance-of-plant development are also addressed. Major emphasis of this product design improvement project is on increased efficiency, compactness and cost reduction to establish a competitive place in the market. A 2.85 MW power plant with an efficiency of 58% and a footprint of 420 m{sup 2} has been designed. Component and subsystem testing is being conducted at various levels. Planning and preparation for verification of a full size prototype unit are in progress. This paper presents the results obtained since the last fuel cell seminar.

  3. Molten carbonate fuel cell product design improvement

    Energy Technology Data Exchange (ETDEWEB)

    P. Voyentzie; T. Leo; A. Kush; L. Christner; G. Carlson; C. Yuh

    1998-12-20

    Drawing on the manufacture, field test, and post-test experience of the sixteen Santa Clara Demonstration Project (SCDP) stacks, ERC is finalizing the next generation commercial entry product design. The second generation cells are 50% larger in area, 40% lighter on equal geometric area basis, and 30% thinner than the earlier design. These improvements have resulted in doubling of the full-height stack power. A low-cost and high-strength matrix has also been developed for improving product ruggedness. The low-cost advanced cell design incorporating these improvements has been refined through six short stack tests. Power production per cell of two times the SCDP maximum power operation, over ten thermal cycles, and overall operating flexibility with respect to load and thermal changes have been demonstrated in these short stack tests. An internally insulated stack enclosure has been designed and fabricated to eliminate the need for an inert gas environment during operation. ERC has acquired the capability for testing 400kW full-height direct fuel ceil (DFC) stack and balance-of-plant equipment. With the readiness of the power plant test facility, the cell package design, and the stack module, full-height stack testing has begun. The first full- height stack incorporating the post-SCDP second generation design was completed. The stack reached a power level of 253 kW, setting a world record for the highest power production from the advanced fuel cell system. Excellent performance uniformity at this power level affirmed manufacturing reproducibility of the components at the factory. This unoptimized small size test has achieved pipeline natural gas to DC electricity conversion efficiency of 47% (based on lower heating value - LHV) including the parasitic power consumed by the BOP equipment; that should translate to more than 50% efficiency in commercial operation, before employing cogeneration. The power plant system also operated smoothly. With the success of this

  4. MOLTEN CARBONATE FUEL CELL PRODUCT DESIGN IMPROVEMENT

    Energy Technology Data Exchange (ETDEWEB)

    H.C. Maru; M. Farooque

    2005-03-01

    The program was designed to advance the carbonate fuel cell technology from full-size proof-of-concept field test to the commercial design. DOE has been funding Direct FuelCell{reg_sign} (DFC{reg_sign}) development at FuelCell Energy, Inc. (FCE, formerly Energy Research Corporation) from an early state of development for stationary power plant applications. The current program efforts were focused on technology and system development, and cost reduction, leading to commercial design development and prototype system field trials. FCE, in Danbury, CT, is a world-recognized leader for the development and commercialization of high efficiency fuel cells that can generate clean electricity at power stations, or at distributed locations near the customers such as hospitals, schools, universities, hotels and other commercial and industrial applications. FCE has designed three different fuel cell power plant models (DFC300A, DFC1500 and DFC3000). FCE's power plants are based on its patented DFC{reg_sign} technology, where a hydrocarbon fuel is directly fed to the fuel cell and hydrogen is generated internally. These power plants offer significant advantages compared to the existing power generation technologies--higher fuel efficiency, significantly lower emissions, quieter operation, flexible siting and permitting requirements, scalability and potentially lower operating costs. Also, the exhaust heat by-product can be used for cogeneration applications such as high-pressure steam, district heating and air conditioning. Several sub-MW power plants based on the DFC design are currently operating in Europe, Japan and the US. Several one-megawatt power plant design was verified by operation on natural gas at FCE. This plant is currently installed at a customer site in King County, WA under another US government program and is currently in operation. Because hydrogen is generated directly within the fuel cell module from readily available fuels such as natural gas and

  5. Conceptual design report of hot cell modification and process for fission Mo-99 production

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Ho; Choung, W. M.; Lee, K. I.; Hwang, D. S.; Kim, Y. K.; Park, K. B.; Jung, Y. J.; Kim, D. S.; Park, Y. C

    2001-05-01

    In this conceptual design report, the basic data and design guides for detail design of fission Mo-99 production process and hot cell modification are included.The basic data and design guides for detail design of fission Mo-99 production process contains following contents. -design capacity, the basic process, process flow diagram, process material balance, process data. The basic data and design guides for modification of existing hot cell contains following contents. - plot plan of hot cell facility, the plan for shield reinforcement of hot cell, the plan for management and storage of high level liquid wastes, the plan of ventilation system, the plan for modification of auxiliary facilities. And also, the results of preliminary safety analysis(normal operation and accidents) and criticality analysis are included in this conceptual design report.

  6. Biomechatronics for designing bioprocess monitoring and control systems: application to stem cell production.

    Science.gov (United States)

    Mandenius, Carl-Fredrik

    2012-12-31

    Stem cell production systems need elaborate monitoring and control for meeting requirements on the final cell product. In this article, the use of biomechatronic design methodology for supporting these efforts is described. Biomechatronic design, which is based on a fundamental systematical design approach originating from mechanical engineering, is here applied for investigating how monitoring and control systems can be configured in stem cell manufacturing processes. Results are provided that demonstrate how the biomechatronic design tools are used to compare different process analytical instrumentation resulting in a design layout for the monitoring system for derivation of hepatocytes from human embryonic stem cells. The results can be extrapolated to other stem cell production processes using the same methodology.

  7. From a co-production design to an integrated single-cell biorefinery.

    Science.gov (United States)

    Liang, Quanfeng; Qi, Qingsheng

    2014-11-15

    Engineering microorganisms capable of accumulating multiple products are sometimes attractive because they yield several advantages in balancing the in vivo metabolic flux and restoring the optimal cell physiology. With the development of metabolic engineering and synthetic biology, numerous strategies for minimizing the substrate waste, optimizing the product portfolios, and maximizing the product yield in co-production systems have been designed and applied. This paper reviewed the recent developments in this field and discussed the challenges that may be encountered during the scaling up of the co-production systems. Finally, the importance of product portfolios and biorefinery strategy of single-cell in co-production processes was proposed.

  8. Models and methods for design and implementation of computer based control and monitoring systems for production cells

    DEFF Research Database (Denmark)

    Lynggaard, Hans Jørgen Birk

    This dissertation is concerned with the engineering, i.e. the designing and making, of industrial cell control systems. The focus is on automated robot welding cells in the shipbuilding industry. The industrial research project defines models and methods for design and implementation of computer...... through the implementation of two cell control systems for robot welding cells in production at Odense Steel Shipyard.It is concluded that cell control technology provides for increased performance in production systems, and that the Cell Control Engineering concept reduces the effort for providing high...

  9. Design, Engineering, and Construction of Photosynthetic Microbial Cell Factories for Renewable Solar Fuel Production

    Energy Technology Data Exchange (ETDEWEB)

    Lindblad, Peter; Lindberg, Pia; Stensjoe, Karin (Photochemistry and Molecular Science, Dept. of Chemistry-Aangstroem Laboratory, Uppsala Univ., Uppsala (Sweden)), E-mail: Peter.Lindblad@kemi.uu.se; Oliveira, Paulo (Instituto de Biologia Molecular e Celular, Porto (Portugal)); Heidorn, Thorsten (Bioforsk-Norwegian Inst. for Agricultural and Environmental Research, Aas Oslo, (Norway))

    2012-03-15

    There is an urgent need to develop sustainable solutions to convert solar energy into energy carriers used in the society. In addition to solar cells generating electricity, there are several options to generate solar fuels. This paper outlines and discusses the design and engineering of photosynthetic microbial systems for the generation of renewable solar fuels, with a focus on cyanobacteria. Cyanobacteria are prokaryotic microorganisms with the same type of photosynthesis as higher plants. Native and engineered cyanobacteria have been used by us and others as model systems to examine, demonstrate, and develop photobiological H{sub 2} production. More recently, the production of carbon-containing solar fuels like ethanol, butanol, and isoprene have been demonstrated. We are using a synthetic biology approach to develop efficient photosynthetic microbial cell factories for direct generation of biofuels from solar energy. Present progress and advances in the design, engineering, and construction of such cyanobacterial cells for the generation of a portfolio of solar fuels, e.g., hydrogen, alcohols, and isoprene, are presented and discussed. Possibilities and challenges when introducing and using synthetic biology are highlighted

  10. Molted carbonate fuel cell product design and improvement - 4th quarter, 1995. Quarterly report, October 1, 1995--December 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The primary objective of this project is to establish the commercial readiness of MW-class IMHEX Molten Carbonate Fuel Cell power plants. Progress is described on marketing, systems design and analysis, product options and manufacturing.

  11. Characterization of a monoclonal antibody cell culture production process using a quality by design approach.

    Science.gov (United States)

    Horvath, Brian; Mun, Melissa; Laird, Michael W

    2010-07-01

    The goal of quality by design (QbD) in cell culture manufacturing is to develop manufacturing processes which deliver products with consistent critical quality attributes (CQAs). QbD approaches can lead to better process understanding through the use of process parameter risk ranking and statistical design of experiments (DOE). The QbD process starts with an analysis of process parameter risk with respect to CQAs and key performance indicators (KPIs). Initial DOE study designs and their factor test ranges are based on the outcomes of the process parameter risk ranking exercises. Initial DOE studies screen factors for significant influences on CQAs as well as characterize responses for process KPIs. In the case study provided here, multifactor process characterization studies using a scale-down model resulted in significant variation in charge heterogeneity of a monoclonal antibody (MAb) as measured by ion-exchange chromatography (IEC). Iterative DOE studies, using both screening and response surface designs, were used to narrow the operating parameter ranges so that charge heterogeneity could be controlled to an acceptable level. The data from the DOE studies were used to predict worst-case conditions, which were then verified by testing at those conditions. Using the approach described here, multivariate process parameter ranges were identified that yield acceptable CQA levels and that still provide operational flexibility for manufacturing.

  12. A new method specifically designed to expose cells isolated in vitro to radon and its decay products.

    Science.gov (United States)

    Petitot, F; Morlier, J P; Debroche, M; Pineau, J F; Chevillard, S

    2002-06-01

    A system was set up to provide direct exposure of cells cultured in vitro to radon and its decay products. Radon gas emanating from a uranium source was introduced at a measured concentration in a closed 10-m(3) exposure chamber. Cells were cultured on the microporous membrane of an insert that was floating over the culture medium in a six-well cluster plate. Plates with cells were placed in an open thermoregulated bath within the chamber. Under these conditions, cells were irradiated by direct deposition of radon and radon decay products. During exposure, all parameters, including radon gas concentrations, decay product activities, and potential alpha-particle energy concentrations, were determined by periodic air-grab samplings inside the chamber. The energy spectrum of deposited decay products was characterized. An estimation of alpha-particle flux density on the area containing cells was performed using CR-39 detector films that were exposed in cell-free wells during the cell exposure. The number of alpha-particle traversals per cell was deduced both from the mean number of CR-39 tracks per surface unit and from measurements of entire cells or nuclear surfaces. This paper describes the design of experiment, the dosimetry of radon and radon decay product, and the procedures for aerosol measurements. Our preliminary data show the usefulness of the in vitro cell culture approach to the study of the early cellular effects of radon and its decay products.

  13. A comprehensive review of microbial electrolysis cells (MEC reactor designs and configurations for sustainable hydrogen gas production

    Directory of Open Access Journals (Sweden)

    Abudukeremu Kadier

    2016-03-01

    Full Text Available Hydrogen gas has tremendous potential as an environmentally acceptable energy carrier for vehicles. A cutting edge technology called a microbial electrolysis cell (MEC can achieve sustainable and clean hydrogen production from a wide range of renewable biomass and wastewaters. Enhancing the hydrogen production rate and lowering the energy input are the main challenges of MEC technology. MEC reactor design is one of the crucial factors which directly influence on hydrogen and current production rate in MECs. The rector design is also a key factor to up-scaling. Traditional MEC designs incorporated membranes, but it was recently shown that membrane-free designs can lead to both high hydrogen recoveries and production rates. Since then multiple studies have developed reactors that operate without membranes. This review provides a brief overview of recent advances in research on scalable MEC reactor design and configurations.

  14. Thermodynamics-based design of microbial cell factories for anaerobic product formation.

    Science.gov (United States)

    Cueto-Rojas, Hugo F; van Maris, A J A; Wahl, S Aljoscha; Heijnen, J J

    2015-09-01

    The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates.

  15. Molten carbonate fuel cell product design and improvement. Quarterly report, December 1994--March 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    Primary objective is to establish the commercial readiness of MW- class IMHEX {reg_sign} MCFC power plants for distributed generation, cogeneration, and compressor station applications. The following tasks are reported: product definition/planning, system design/analysis, manufacturing process development, packaging/assembly, test facilities, and technology development/improvement/verification.

  16. Application of a quality by design approach to the cell culture process of monoclonal antibody production, resulting in the establishment of a design space.

    Science.gov (United States)

    Nagashima, Hiroaki; Watari, Akiko; Shinoda, Yasuharu; Okamoto, Hiroshi; Takuma, Shinya

    2013-12-01

    This case study describes the application of Quality by Design elements to the process of culturing Chinese hamster ovary cells in the production of a monoclonal antibody. All steps in the cell culture process and all process parameters in each step were identified by using a cause-and-effect diagram. Prospective risk assessment using failure mode and effects analysis identified the following four potential critical process parameters in the production culture step: initial viable cell density, culture duration, pH, and temperature. These parameters and lot-to-lot variability in raw material were then evaluated by process characterization utilizing a design of experiments approach consisting of a face-centered central composite design integrated with a full factorial design. Process characterization was conducted using a scaled down model that had been qualified by comparison with large-scale production data. Multivariate regression analysis was used to establish statistical prediction models for performance indicators and quality attributes; with these, we constructed contour plots and conducted Monte Carlo simulation to clarify the design space. The statistical analyses, especially for raw materials, identified set point values, which were most robust with respect to the lot-to-lot variability of raw materials while keeping the product quality within the acceptance criteria.

  17. Chemical Product Design

    DEFF Research Database (Denmark)

    Gani, Rafiqul

    2004-01-01

    This paper highlights for a class of chemical products, the design process, their design with respect to the important issues, the need for appropriate tools and finally, lists some of the challenges and opportunities for the process systems engineering (PSE)/computer-aided process engineering...

  18. Design of a microbial fuel cell and its transition to microbial electrolytic cell for hydrogen production by electrohydrogenesis.

    Science.gov (United States)

    Gupta, Pratima; Parkhey, Piyush; Joshi, Komal; Mahilkar, Anjali

    2013-10-01

    Anaerobic bacteria were isolated from industrial wastewater and soil samples and tested for exoelectrogenic activity by current production in double chambered microbial fuel cell (MFC), which was further transitioned into a single chambered microbial electrolytic cell to test hydrogen production by electrohydrogenesis. Of all the cultures, the isolate from industrial water sample showed the maximum values for current = 0.161 mA, current density = 108.57 mA/m2 and power density = 48.85 mW/m2 with graphite electrode. Maximum voltage across the cell, however, was reported by the isolate from sewage water sample (506 mv) with copper as electrode. Tap water with KMnO4 was the best cathodic electrolyte as the highest values for all the measured MFC parameters were reported with it. Once the exoelectrogenic activity of the isolates was confirmed by current production, these were tested for hydrogen production in a single chambered microbial electrolytic cell (MEC) modified from the MFC. Hydrogen production was reported positive from co-culture of isolates of both the water samples and co-culture of one soil and one water sample. The maximum rate and yield of hydrogen production was 0.18 m3H2/m3/d and 3.2 mol H2/mol glucose respectively with total hydrogen production of 42.4 mL and energy recovery of 57.4%. Cumulative hydrogen production for a five day cycle of MEC operation was 0.16 m3H2/m3/d.

  19. Differential Electrochemical Mass Spectrometer Cell Design for Online Quantification of Products Produced during Electrochemical Reduction of CO₂.

    Science.gov (United States)

    Clark, Ezra L; Singh, Meenesh R; Kwon, Youngkook; Bell, Alexis T

    2015-08-01

    The discovery of electrocatalysts that can efficiently reduce CO2 to fuels with high selectivity is a subject of contemporary interest. Currently, the available analytical methods for characterizing the products of CO2 reduction require tens of hours to obtain the dependence of product distribution on applied potential. As a consequence, there is a need to develop novel analytical approaches that can reduce this analysis time down to about an hour. We report here the design, construction, and operation of a novel differential electrochemical mass spectrometer (DEMS) cell geometry that enables the partial current densities of volatile electrochemical reaction products to be quantified in real time. The capabilities of the novel DEMS cell design are demonstrated by carrying out the electrochemical reduction of CO2 over polycrystalline copper. The reaction products are quantified in real time as a function of the applied potential during linear sweep voltammetry, enabling the product spectrum produced by a given electrocatalyst to be determined as a function of applied potential on a time scale of roughly 1 h.

  20. Computer aided product design

    DEFF Research Database (Denmark)

    Constantinou, Leonidas; Bagherpour, Khosrow; Gani, Rafiqul

    1996-01-01

    A general methodology for Computer Aided Product Design (CAPD) with specified property constraints which is capable of solving a large range of problems is presented. The methodology employs the group contribution approach, generates acyclic, cyclic and aromatic compounds of various degrees......-liquid equilibria (LLE), solid-liquid equilibria (SLE) and gas solubility. Finally, a computer program based on the extended methodology has been developed and the results from five case studies highlighting various features of the methodology are presented....

  1. MCFC product design improvement

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1999-05-01

    This contract is supported by DOE and DOD/DARPA funds. The objective of the DOE program is to advance the direct carbonate fuel cell technology to a level suitable for commercial entry. The specific objectives of the DOE's initiative on 2 MW Fuel Cell Fixed Base Power Plant are: (A) To provide a detailed engineering design, development and cost estimate of the 2 MW fuel cell fixed base dual fuel power plant for DOD applications. Installation and operational support systems will also be developed; and (B) To construct a full-size MW-class dual fuel power plant simulator. These objectives are planned to be achieved in the program coordinated with the Department of Energy, which has been funding a multiyear natural gas fueled direct fuel cell power plant program for civilian applications. Because many DARPA and DOE objectives are similar, the coordinated program activities are considered the most cost-effective for accomplishment of the program objectives. The DARPA/DOE joint program was launched in 1994. The DOE part of the program is expected to continue to the year 2000. The final output of this DOE program is to construct and operate a 2 MW power plant on an East Coast site. The site will be accessible to DOD energy/environmental systems base planners and logistics personnel as well as mission and policy planners to refine deployment configurations of this new power generation system for fixed base applications. A dual fuel fixed base design for military fuels operation, as well as support system logistics will be the key deliverables for the DARPA part of the program.

  2. Design of resilient consumer products

    DEFF Research Database (Denmark)

    Haug, Anders

    2016-01-01

    Consumer product sustainability is a topic that has been of increasing interest to practice and academia in recent decades. In this context, a widely discussed means of achieving sustainability is to design more durable products, thereby reducing the need for the production of new products....... In particular, the emotional perspective on product durability has received attention in recent design literature, since consumer products are often replaced long before they become physically non-functioning. However, the literature does not provide a full account of the causes of product replacement...... for designers to design resilient consumer products and for researchers to engage in further studies....

  3. Production Design: Holding It Together.

    Science.gov (United States)

    Connelly, James O.

    1994-01-01

    Discusses production design for videos. Outlines general considerations (opening, transitions, content areas, and closing) and specific considerations (typography, screen design, music, and sound effects). Offers an example. (SR)

  4. Improving pension product design

    DEFF Research Database (Denmark)

    Konicz, Agnieszka Karolina; Mulvey, John M.

    2013-01-01

    utility of retirement benefits is maximized. An asset allocation strategy should not only depend on the plan member's age (or time left to retirement), nor only on her risk preferences, but should capture personal characteristics. Among other factors, we include current wealth, expected lifetime salary...... products are designed with a tendency to assume greater risk the longer it is until retirement, but are not adjusted to individual preferences and circumstances. This paper develops an optimal asset allocation strategy for a defined contribution plan by adjusting to individual needs, such that the expected...... progression, expected social benefits, choice of assets, type of retirement distribution schedules, bequest motive and life insurance. The problem is solved via a model that combines two optimization technologies: stochastic control and multi-stage stochastic linear programming (SLP). As an example...

  5. Production Target Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Olivas, Eric Richard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-28

    The Northstar 99Mo production target, a cylindrical length of 100Mo rod, has evolved considerably since its first conception.  The cylinder was very early sliced into disks to increase the heat transfer area, first to 1 mm thick disks then to the current 0.5 mm thick.  The coolant was changed early in the target development from water to helium to eliminate corrosion and dissolution.  The diameter has increased from initially 6 mm to 12 mm, the current diameter of the test target now at ANL, to nominally 28 mm (26-30.6 mm, depending upon optimal beam spot size and shape).  The length has also changed to improve the production to cost ratio, so now the target is nominally 41 mm long (excluding coolant gaps between disks), and irradiated on both ends.  This report summarizes the current status of the plant target design.

  6. Designing Product Families

    DEFF Research Database (Denmark)

    Pedersen, Per Erik Elgård; Miller, Thomas Dedenroth

    1998-01-01

    Manufacturing companies that operate with products aimed at different market segments and applications are experiencing an increasing demand from customers who expect products to be tailored to their exact needs rather than accepting general products based on average customer needs. This trend ha...... led to a new business paradigm, "mass customization", where companies strive to provide highly customized products while still maintaining the efficiency of the classical mass production enterprise. One of the key factors in mass customization has been efficient use of product platforms...... as a foundation for the customization process, whereby the customized products become variants of a product family with a high degree of reuse and utilization of kinship between the individual variants.With this paper, we will discuss the development of platform based product families from three points of view...

  7. Product design - Molecules, devices, functional products, and formulated products

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Ng, Ka M.

    2015-01-01

    Chemical product design is a multidisciplinary and diverse subject. This article provides an overview of product design while focusing on product conceptualization. Four product types are considered - molecular products, formulated products, devices and functional products. For molecular products......, computer-aided design tools are used to predict the physicochemical properties of single molecules and blends. For formulated products, an integrated experiment-modeling approach is used to generate the formula with the specified product attributes. For devices and functional products, conceptual product...... design is carried out by modeling the product based on thermodynamics, kinetics and transport processes, by performing experiments, and by decision making based on rule-based methods The results are product specifications in terms of the type of ingredients, composition, and the structure, form, shape...

  8. ADAPTABLE DESIGN IN PRODUCT DEVELOPMENT

    Institute of Scientific and Technical Information of China (English)

    WU Qingming; MEI Huafeng

    2006-01-01

    A newly emerging design pattern, named as adaptable design (AD), which aims at developing products that are adaptable from design to post-life cycle, is discussed. AD consists of four main phases: product modeling, design platform, specific design and product redesign. A new process-based design data model (PDDM) is presented which is organized according to the principles of conveniem knowledge extraction, data representation, layout, sharing and reuse. Based on the PDDM, a universal design platform for product family development is established, which has characters of modularity, parameter-driven, variant design, etc. The framework of the platform is also proposed as a conceptual structure and overall logical organization for generating a family of products. AD methodology is successfully applied to develop a family of tunnel boring machine (TBM) for different engineering projects, with the efficiency of our developing team being greatly increased.

  9. Scenario based product design

    NARCIS (Netherlands)

    Tideman, M.

    2008-01-01

    Creating good products is not an easy thing to do. There are usually many different people who have an interest in the product. People such as the user, of course, but also marketing managers, production engineers, maintenance workers, recycling specialists, and government representatives, just to n

  10. Micro Products - Product Development and Design

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard

    2003-01-01

    -disciplinary competences. One example is sensors for chemical analysis of fluids, where chemistry, biology and flow mechanics all influence the design of the product and thereby the industrial fabrication of the product [1]. On the technological side the development has moved very fast, primarily driven by the need...... of the electronics industry to create still smaller chips with still larger capacity. Therefore the manufacturing technologies connected with micro/nano products in silicon are relatively highly developed compared to the technologies used for manufacturing micro products in metals, polymers and ceramics. For all...... technologies, however, it is a continuously increasing challenge to create the operational basis for an industrial production of micro products. As the products through product development processes are made applicable to a large number of customers, the pressure in regard to developing production technologies...

  11. Culture-Orientated Product Design

    Science.gov (United States)

    Moalosi, Richie; Popovic, Vesna; Hickling-Hudson, Anne

    2010-01-01

    There is little in-depth research that can assist designers to use culture as a catalyst for designing innovative products within Botswana's context. The concept of culture and design are intertwined, thus modifications stemming from cultural evolution both reflect and determine developments in design. The paper discusses an experimental design…

  12. Product sound design in education

    NARCIS (Netherlands)

    Langeveld, L.H.; Jansen, R.J.; van Egmond, R.

    2012-01-01

    Product Sound Design is an elective course of the Master of Industrial Design Engineering at the Delft University of Technology. The educational goal of the course is to make students consciously aware of constructive parts in the design of appliances. The paper details the experience and the design

  13. Future product design

    DEFF Research Database (Denmark)

    Andreasen, Mogens Myrup

    1997-01-01

    This paper (in form of overheads) formulate new challenges and possibilities for engineering design, utilizing rationalization effect from modularisation, re-use and transparaency.......This paper (in form of overheads) formulate new challenges and possibilities for engineering design, utilizing rationalization effect from modularisation, re-use and transparaency....

  14. Improving designer productivity. [artificial intelligence

    Science.gov (United States)

    Hill, Gary C.

    1992-01-01

    Designer and design team productivity improves with skill, experience, and the tools available. The design process involves numerous trials and errors, analyses, refinements, and addition of details. Computerized tools have greatly speeded the analysis, and now new theories and methods, emerging under the label Artificial Intelligence (AI), are being used to automate skill and experience. These tools improve designer productivity by capturing experience, emulating recognized skillful designers, and making the essence of complex programs easier to grasp. This paper outlines the aircraft design process in today's technology and business climate, presenting some of the challenges ahead and some of the promising AI methods for meeting these challenges.

  15. Natural product-based design, synthesis and biological evaluation of Albiziabioside A derivatives that selectively induce HCT116 cell death.

    Science.gov (United States)

    Wei, Gaofei; Cui, Shanshan; Luan, Weijing; Wang, Shuai; Hou, Zhuang; Liu, Yongxiang; Liu, Yang; Cheng, Maosheng

    2016-05-04

    A series of Albiziabioside A coupled substituents of cinnamoyl derivatives were designed and synthesized. The synthesized compounds were screened for anticancer activity against a panel of six human cancer cell lines using a MTT assay. Synthetic derivatives showed excellent selectivity, as they were toxic against only HCT116 cell line. Some compounds exhibited better anti-cancer activity against HCT116 compared to positive controls, such as 5-fluorouracil and Albiziabioside A. Compound 8n was the most active derivative. Importantly, it was also found that the anti-proliferative activity of 8n could be attributed to the induction of cell cycle arrest and apoptosis in HCT116 cells.

  16. Rational design of medium supplementation strategy for improved influenza viruses production based on analyzing nutritional requirements of MDCK Cells.

    Science.gov (United States)

    Huang, Ding; Xia-Hou, Kang; Liu, Xu-Ping; Zhao, Liang; Fan, Li; Ye, Zhaoyang; Tan, Wen-Song; Luo, Jian; Chen, Ze

    2014-12-12

    Influenza vaccine production using cell culture technology has become popular nowadays. However, to meet the ever increasing demand of influenza vaccine, it is prerequisite to improve the yield of influenza virus in cells. To achieve this, in the present study, the nutritional requirements of MDCK cells in the virus production process were analyzed and a nutrient-feeding strategy was developed accordingly. Based on the consumption rates and corresponding concentration optimization, glucose and fast metabolized amino acids were supplemented into the maintaining medium at the time of infection. Compared with the non-supplemented culture, the average cell specific death rate during 0-48 h post-infection was 0.013 h(-1), which was 40.91% lower in the nutrient-supplemented culture. Total virus titer, HA antigen protein concentration and cell-specific virus yield were (1.88±0.23)×10(3) HA units/50μL, 11.70±0.22 μg/mL and (10.06±1.16)×10(3) virions/cell, respectively, which were 84.04±22.50%, 31.46±2.87% and 86.64±25.81% higher than those in the control, respectively. These data showed that the appropriate supplementation of nutrients during virus production process could reduce cell death, and improve cell-specific virus yield and total influenza virus output. This study laid foundation for the development of cell culture technology for influenza vaccine production.

  17. Design of a chamber for production and in-situ characterization of small-molecule photovoltaic cells

    Energy Technology Data Exchange (ETDEWEB)

    Ligorio, Giovanni; Lange, Simeon; Lorch, Christopher; Reinhardt, Jens; Hinderhofer, Alexander; Gerlach, Alexander; Schreiber, Frank [Institut fuer Angewandte Physik, Universitaet Tuebingen, 72076 Tuebingen (Germany)

    2011-07-01

    The design and construction of an integrated ultra-high vacuum system to produce and characterize organic small-molecule solar cells is presented. Through the new system, it is possible to produce several solar cells simultaneously on the same ITO substrate via organic molecular beam deposition under vacuum conditions. In-situ electric contact is achieved through aluminum deposition. With the sample holder the temperature can be systematically modified between 200 K and 700 K while liquid nitrogen cooling or resistive heating to control the deposition process and to permit temperature dependent measurements. We present first results for OPV cells of diindenoperylene (DIP)/C{sub 60} and DIP/perfluoropentacene (PFP).

  18. Mechatronics design principles for biotechnology product development.

    Science.gov (United States)

    Mandenius, Carl-Fredrik; Björkman, Mats

    2010-05-01

    Traditionally, biotechnology design has focused on the manufacture of chemicals and biologics. Still, a majority of biotechnology products that appear on the market today is the result of mechanical-electric (mechatronic) construction. For these, the biological components play decisive roles in the design solution; the biological entities are either integral parts of the design, or are transformed by the mechatronic system. This article explains how the development and production engineering design principles used for typical mechanical products can be adapted to the demands of biotechnology products, and how electronics, mechanics and biology can be integrated more successfully. We discuss three emerging areas of biotechnology in which mechatronic design principles can apply: stem cell manufacture, artificial organs, and bioreactors.

  19. Improving pension product design

    DEFF Research Database (Denmark)

    Konicz, Agnieszka Karolina; Mulvey, John M.

    to individual needs. We argue that the asset allocation, the payout prole and the insured sum should not only depend on the plan member's age (or time left to retirement), nor only on her risk preferences, but should capture personal and economical characteristics. Among other factors, we include current wealth......, expected lifetime salary progression, mandatory and voluntary pension contributions, expected state retirement pension, choice of assets, subjective lifetime expectancy and bequest motive. Specically, the asset allocation strategy, the payout prole and the level of insured sum dening the new product...

  20. Use of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells.

    Science.gov (United States)

    González-Leal, I J; Carrillo-Cocom, L M; Ramírez-Medrano, A; López-Pacheco, F; Bulnes-Abundis, D; Webb-Vargas, Y; Alvarez, M M

    2011-01-01

    Culture media design is central to the optimization of monoclonal antibody (mAb) production. Although general strategies do not currently exist for optimization of culture media, the combined use of statistical design and analysis of experiments and strategies based on simple material balances can facilitate culture media design. In this study, we evaluate the effect of selected amino acids on the growth rate and monoclonal antibody production of a Chinese hamster ovary DG-44 (CHO-DG44) cell line. These amino acids were selected based on their relative mass fraction in the specific mAb produced in this study, their consumption rate during bioreactor experiments, and also through a literature review. A Plackett-Burman statistical design was conducted to minimize the number of experiments needed to obtain statistically relevant information. The effect of this set of amino acids was evaluated during exponential cell culture (considering viable cell concentration and the specific growth rate as main output variables) and during the high cell-density stage (considering mAb final concentration and specific productivity as relevant output variables). For this particular cell line, leucine (Leu) and arginine (Arg) had the highest negative and positive effects on cell viability, respectively; Leu and threonine (Thr) had the highest negative effect on growth rate, and valine (Val) and Arg demonstrated the highest positive impact on mAb final concentration. Results suggest the pertinence of a two-stage strategy for amino acid supplementation, with a mixture optimized for cell growth and a different amino acid mixture for mAb production at high density.

  1. Production Facility SCADA Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Holloway, Michael Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Baily, Scott A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Wheat, Robert Mitchell Jr. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-03-23

    The following report covers FY 14 activities to develop supervisory control and data acquisition (SCADA) system for the Northstar Moly99 production facility. The goal of this effort is to provide Northstar with a baseline system design.

  2. Molten carbonate fuel cell product design improvement tracer tests. Topical report, December 20, 1995--December 20, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    ERC is developing the detailed design of the commercial entry MW-class power plant. The product requirements and specifications have been derived. The planned baseline power plant is rated at 2.85 MW on natural gas and has a heat rate of 6.22 {times} 10{sup 6} J/kWh (5900 Btu/kWh; 58% LHV). Additional optional features will be available to include non-standard site conditions and other fuels. In parallel, the baseline product design has progressed to the final design phase. The preliminary product design, which also included parametric optimization, major component vendor interaction, and cost estimation, has been completed during the past year. The power plant approach consists of several factory-constructed truck-transportable modules. A computer-generated power plant layout is shown in a figure. The proposed power plant is expected to have a gross output of 3.03 MW, providing net 2.85 MW AC. The parasitic power loss is approximately 6%, of which, inverter, step-up transformer, BOP motors, and miscellaneous loads consume 2%, 1%, 2%, and 1%, respectively.

  3. Cork for sustainable product design

    NARCIS (Netherlands)

    Mestre, A.C.; Gil, L.

    2011-01-01

    Sustainable Product Design is currently accepted as one of the most promising trends in the “Sustainable Development” movement. It is often seen as a facilitation tool to implement Sustainability in practice, by improving the life cycle and eco-efficiency of products, by promoting dematerialization

  4. Selecting materials in product design

    NARCIS (Netherlands)

    Van Kesteren, I.E.H.

    2008-01-01

    This thesis exists of several studies and design steps that resulted in a new material selection technique for user-centred design, which is supported by tools. The tools use examples of materials in products and stimulate the discussions about the user-interaction aspects of those materials desired

  5. Solar Thermochemical Hydrogen Production Plant Design

    OpenAIRE

    Littlefield, Jesse

    2012-01-01

    A plant was designed that uses a solar sulfur-ammonia thermochemical water-splitting cycle for the production of hydrogen. Hydrogen is useful as a fuel for stationary and mobile fuel cells. The chemical process simulator Aspen Plus® was used to model the plant and conduct simulations. The process utilizes the electrolytic oxidation of aqueous ammonium sulfite in the hydrogen production half cycle and the thermal decomposition of molten potassium pyrosulfate and gaseous sulfur trioxide in t...

  6. Total design for textile products

    Directory of Open Access Journals (Sweden)

    Zafirova Koleta

    2004-01-01

    Full Text Available Product development is less than 20-30 years old and a relatively new area of research compared to the other classic academic disciplines. Integrated product development is a philosophy that systematically employs the teaming of functional disciplines to integrate and concurrently apple all the necessary processes to produce an effective and efficient product that satisfies customer needs. Product development might also be understood as a multidisciplinary field of research. The disciplines directly participating in product development include engineering design, innovation, manufacturing, marketing and management. A background contribution is also generated by disciplines such as psychology, social sciences and information technology. This article is an overview that introduces this philosophy to textile product development.

  7. Global Product Development and Design

    Directory of Open Access Journals (Sweden)

    Tengüz Ünsal

    2009-12-01

    Full Text Available The new product development (NPD process plays an increasingly important role in global economic competition. The competition to win business in overseas markets among product manufacturing companies operating at an international level is fierce. Hence companies located in the more established industrialized countries are now using the latest technology to maintain their trading position in the face of highly fragmented international markets, this has forced them to speed up the product development process. Thus to remain competitive within international markets, designers must be part of a global design activity. The creation of new products involves various disciplines including industrial design, marketing and manufacturing. Therefore, the process of NPD requires an awareness and understanding of the factors which influence inter-disciplinary and cross cultural-design. This paper focuses on the NPD activities of two notable consumer manufacturing industries in order to identify the characteristics of their global NPD processes and their operational requirements in an organization based across the globe. It also aims to draw the attention to the role of industrial design within the global NPD process.

  8. Statistical design and optimization of single cell oil production from sugarcane bagasse hydrolysate by an oleaginous yeast Rhodotorula sp. IIP-33 using response surface methodology.

    Science.gov (United States)

    Bandhu, Sheetal; Dasgupta, Diptarka; Akhter, Jawed; Kanaujia, Pankaj; Suman, Sunil K; Agrawal, Deepti; Kaul, Savita; Adhikari, Dilip K; Ghosh, Debashish

    2014-01-01

    Single cell oil production from sugarcane bagasse hydrolysate by oleaginous yeast Rhodotorula sp. IIP-33 was analyzed using a two stage statistical design approach based on Response Surface Methodology. Variables like pentose sugar, (NH4)2SO4, KH2PO4, yeast extract, pH and temperature were found to influence lipid production significantly. Under optimized condition in a shake flask, yield of lipid was 2.1199 g with fat coefficient of 7.09 which also resembled ~99% similarity to model predicted lipid production. In this paper we are presenting optimized results for production of non polar lipid which could be later deoxygenated into hydrocarbon. A qualitative analyses of selective lipid samples yielded a varying distribution of free acid ranging from C6 to C18, majoring C16:0, C18:0 and C18:1 under different fermentation conditions.

  9. Operational, design and microbial aspects related to power production with microbial fuel cells implemented in constructed wetlands.

    Science.gov (United States)

    Corbella, Clara; Guivernau, Miriam; Viñas, Marc; Puigagut, Jaume

    2015-11-01

    This work aimed at determining the amount of energy that can be harvested by implementing microbial fuel cells (MFC) in horizontal subsurface constructed wetlands (HSSF CWs) during the treatment of real domestic wastewater. To this aim, MFC were implemented in a pilot plant based on two HSSF CW, one fed with primary settled wastewater (Settler line) and the other fed with the effluent of a hydrolytic up-flow sludge blanket reactor (HUSB line). The eubacterial and archaeal community was profiled on wetland gravel, MFC electrodes and primary treated wastewater by means of 16S rRNA gene-based 454-pyrosequencing and qPCR of 16S rRNA and mcrA genes. Maximum current (219 mA/m(2)) and power (36 mW/m(2)) densities were obtained for the HUSB line. Power production pattern correlated well with water level fluctuations within the wetlands, whereas the type of primary treatment implemented had a significant impact on the diversity and relative abundance of eubacteria communities colonizing MFC. It is worth noticing the high predominance (13-16% of relative abundance) of one OTU belonging to Geobacter on active MFC of the HUSB line that was absent for the settler line MFC. Hence, MFC show promise for power production in constructed wetlands receiving the effluent of a HUSB reactor.

  10. Computational Intelligence Techniques for New Product Design

    CERN Document Server

    Chan, Kit Yan; Dillon, Tharam S

    2012-01-01

    Applying computational intelligence for product design is a fast-growing and promising research area in computer sciences and industrial engineering. However, there is currently a lack of books, which discuss this research area. This book discusses a wide range of computational intelligence techniques for implementation on product design. It covers common issues on product design from identification of customer requirements in product design, determination of importance of customer requirements, determination of optimal design attributes, relating design attributes and customer satisfaction, integration of marketing aspects into product design, affective product design, to quality control of new products. Approaches for refinement of computational intelligence are discussed, in order to address different issues on product design. Cases studies of product design in terms of development of real-world new products are included, in order to illustrate the design procedures, as well as the effectiveness of the com...

  11. Experimental evaluation of a breadboard heat and product-water removal system for a space-power fuel cell designed with static water removal and evaporative cooling

    Science.gov (United States)

    Hagedorn, N. H.; Prokipius, P. R.

    1977-01-01

    A test program was conducted to evaluate the design of a heat and product-water removal system to be used with fuel cell having static water removal and evaporative cooling. The program, which was conducted on a breadboard version of the system, provided a general assessment of the design in terms of operational integrity and transient stability. This assessment showed that, on the whole, the concept appears to be inherently sound but that in refining this design, several facets will require additional study. These involve interactions between pressure regulators in the pumping loop that occur when they are not correctly matched and the question of whether an ejector is necessary in the system.

  12. 基于协作元的产品协同设计研究%PRODUCT COOPERATIVE DESIGN BASED ON COLLABORATION CELL

    Institute of Scientific and Technical Information of China (English)

    储备; 蔡青; 武俊峰; 杨海波

    2001-01-01

    The organization,optimization and dynamical control of design assignments are key issues of product cooperative design. Existing methods for product cooperative design focus on the disposing of business process. They do not take into account the optimum way of distributing subtasks in design. An idea of "collaboration cell"is presented which is made up of designer, personnel cooperative agent(PCAgent)and design tools. A model of invitation and bid is put forward to reasonably deploy subtasks in product design based on PCAgent and task bulletin board, with the decision-making bid in PCAgent and the definition of Ability operator, Famine operator and Importance operator. The"key path"method is also presented to control and optimize the period of design, which can inspect whether the task is reasonably distributed into subtasks or not. The experiment in engineering indicates the rationality and validity of all methods which provide the dearly theoretical foundation for the organization,optimization,deployment and control of all design assignments, and obviously improve the product cooperative design.%设计任务的组织、优化及动态控制都是产品协同设计的关键问题。引入了以设计人、个人协同代理、设计工 具为内容的"协作元"概念。以个人协同代理和任务公告模板为基础,通过招投标模型实现产品设计任务的合理配 置,并提出关键路径法控制产品设计周期。工程实例表明,所提方法合理有效,设计任务的组织、分解、配置、控制 有了明显的理论依据,对产品协同设计水平有明显的提高作用。

  13. Product Life Design: Notes for course 41627

    DEFF Research Database (Denmark)

    McAloone, Timothy Charles; Andreasen, Mogens Myrup

    2003-01-01

    The course in product life design is designed to give an understanding of the phenomena of life cycle and product life thinking, the role of product design in fitting to product life systems and thus achieving sound product life perspectives. The course aims at developing an ability in the studen...

  14. Rational design of efficient modular cells.

    Science.gov (United States)

    Trinh, Cong T; Liu, Yan; Conner, David J

    2015-11-01

    The modular cell design principle is formulated to devise modular (chassis) cells. These cells can be assembled with exchangeable production modules in a plug-and-play fashion to build microbial cell factories for efficient combinatorial biosynthesis of novel molecules, requiring minimal iterative strain optimization steps. A modular cell is designed to be auxotrophic, containing core metabolic pathways that are necessary but insufficient to support cell growth and maintenance. To be functional, it must tightly couple with an exchangeable production module containing auxiliary metabolic pathways that not only complement cell growth but also enhance production of targeted molecules. We developed a MODCELL (modular cell) framework based on metabolic pathway analysis to implement the modular cell design principle. MODCELL identifies genetic modifications and requirements to construct modular cell candidates and their associated exchangeable production modules. By defining the degree of similarity and coupling metrics, MODCELL can evaluate which exchangeable production module(s) can be tightly coupled with a modular cell candidate. We first demonstrated how MODCELL works in a step-by-step manner for example metabolic networks, and then applied it to design modular Escherichia coli cells for efficient combinatorial biosynthesis of five alcohols (ethanol, propanol, isopropanol, butanol and isobutanol) and five butyrate esters (ethyl butyrate, propyl butyrate, isopropyl butyrate, butyl butyrate and isobutyl butyrate) from pentose sugars (arabinose and xylose) and hexose sugars (glucose, mannose, and galactose) under anaerobic conditions. We identified three modular cells, MODCELL1, MODCELL2 and MODCELL3, that can couple well with Group 1 of modules (ethanol, isobutanol, butanol, ethyl butyrate, isobutyl butyrate, butyl butyrate), Group 2 (isopropanol, isopropyl butyrate), and Group 3 (propanol, isopropanol), respectively. We validated the design of MODCELL1 for anaerobic

  15. Design and Fabrication of a Dual-Photoelectrode Fuel Cell towards Cost-Effective Electricity Production from Biomass.

    Science.gov (United States)

    Zhang, Bingqing; Fan, Wenjun; Yao, Tingting; Liao, Shichao; Li, Ailong; Li, Deng; Liu, Mingyao; Shi, Jingying; Liao, Shijun; Li, Can

    2017-01-10

    A photo fuel cell (PFC) offers an attractive way to simultaneously convert solar and biomass energy into electricity. Photocatalytic biomass oxidation on a semiconductor photoanode combined with dark electrochemical reduction of oxygen molecules on a metal cathode (usually Pt) in separated compartments is the common configuration for a PFC. Herein, we report a membrane-free PFC based on a dual electrode, including a W-doped BiVO4 photoanode and polyterthiophene photocathode for solar-stimulated biomass-to-electricity conversion. Air- and water-soluble biomass derivatives can be directly used as reagents. The optimal device yields an open-circuit voltage (VOC ) of 0.62 V, a short-circuit current density (JSC ) of 775 μA cm(-2) , and a maximum power density (Pmax ) of 82 μW cm(-2) with glucose as the feedstock under tandem illumination, which outperforms dual-photoelectrode PFCs previously reported. Neither costly separating membranes nor Pt-based catalysts are required in the proposed PFC architecture. Our work may inspire rational device designs for cost-effective electricity generation from renewable resources.

  16. Rapid thermal processing for production of chalcopyrite thin films for solar cells: Design, analysis, and experimental implementation

    Science.gov (United States)

    Lovelett, Robert J.

    The direct conversion of solar energy to electricity, or photovoltaic energy conversion, has a number of environmental, social, and economic advantages over conventional electricity generation from fossil fuels. Currently, the most commonly-used material for photovoltaics is crystalline silicon, which is now produced at large scale and silicon-based devices have achieved power conversion efficiencies over 25% However, alternative materials, such as inorganic thin films, offer a number of advantages including the potential for lower manufacturing costs, higher theoretical efficiencies, and better performance in the field. One of these materials is the chalcopyrite Cu(InGa)(SeS) 2, which has demonstrated module efficiencies over 17% and cell efficiencies over 22%. Cu(InGa)(SeS)2 is now in the early stages of commercialization using a precursor reaction process referred to as a "selenization/sulfization" reaction. The precursor reaction process is promising because it has demonstrated high efficiency along with the large area (approximately 1 m2) uniformity that is required for modules. However, some challenges remain that limit the growth of the chalcopyrite solar cell industry including: slow reactions that limit process throughput, a limited understanding of complex reaction kinetics and transport phenomena that affect the through-film composition, and the use of highly toxic H2Se in the reaction process. In this work, I approach each of these challenges. First, to improve process throughput, I designed and implemented a rapid thermal processing (RTP) reactor, whereby the samples are heated by a 1000 W quartz-halogen lamp that is capable of fast temperature ramps and high temperature dwells. With the reactor in place, however, achieving effective temperature control in the thin film material system is complicated by two intrinsic process characteristics: (i) the temperature of the Cu(InGa)(SeS)2 film cannot be measured directly, which leaves the system without

  17. Interoperability of Design Intent in Integrated Product and Process Design

    Institute of Scientific and Technical Information of China (English)

    M; W; Fu; W; F; Lu; A; Y; C; Nee; S; K; Ong

    2002-01-01

    Concurrent engineering is currently an overwhelming t rend in product development since it takes the down-stream product development issues and product life-cycle issues into consideration in up-front design pro cess. At this stage, evaluation, verification and validation of design concepts and design schemes is critical to the right-to-market product development. I dentification and extraction of design intent from the part digital mock-ups in different data formats and created in different CAD syste...

  18. RESEARCH ON PRODUCT INNOVATION DESIGN IN VIRTUAL PRODUCT DEVELOPMENT

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    An integrated template of virtual product development alters primarily sequential tradition mode of product lifecycle. The template integrates all processes of product development using digital modem. An environment of virtual pro-duct development provides product development environment of integration, communion, network, concurrent and col-laboration. Combining development of new rapier loom, an innovated design process is researched in virtual product de-velopment, which consists three portions: constructing an integration development environment, innovation design andmanufacturing simulation. The innovated design process realizes reverse design, mechanism concept design, structuraldesign and analysis, performalce analysis and manufacturing process simulation of virtual product, which can enhancegreatly product performance and reduce cost and development cycle of new product.

  19. XML-based product information processing method for product design

    Science.gov (United States)

    Zhang, Zhen Yu

    2012-01-01

    Design knowledge of modern mechatronics product is based on information processing as the center of the knowledge-intensive engineering, thus product design innovation is essentially the knowledge and information processing innovation. Analysis of the role of mechatronics product design knowledge and information management features, a unified model of XML-based product information processing method is proposed. Information processing model of product design includes functional knowledge, structural knowledge and their relationships. For the expression of product function element, product structure element, product mapping relationship between function and structure based on the XML model are proposed. The information processing of a parallel friction roller is given as an example, which demonstrates that this method is obviously helpful for knowledge-based design system and product innovation.

  20. CIRP Design 2012 Sustainable Product Development

    CERN Document Server

    2013-01-01

    During its life cycle, a product produces waste that is over 20 times its weight. As such it is critical to develop products that are sustainable. Currently product development processes lack high quality methods and tools that are empirically validated to support development of sustainable products. This book is a compilation of over forty cutting edge international research papers from the 22nd CIRP International Design Conference, written by eminent researchers from 15 countries, on engineering design process, methods and tools, broadly for supporting sustainable product development.   A variety of new insights into the product development process, as well as a host of methods and tools that are at the cutting edge of design research are discussed and explained covering a range of diverse topics. The areas covered include: ·Sustainable design and manufacturing, ·Design synthesis and creativity, ·Global product development and product life cycle management, ·Design for X (safety, reliability, manufactu...

  1. Product Implications of Design Offshoring

    DEFF Research Database (Denmark)

    Herbert-Hansen, Zaza Nadja Lee; Ahmed-Kristensen, Saeema

    2011-01-01

    This paper investigates the impact offshoring of product development has on the product and suggest possible ways the negative impacts can be avoided.......This paper investigates the impact offshoring of product development has on the product and suggest possible ways the negative impacts can be avoided....

  2. Red blood cell production

    Science.gov (United States)

    ... to one part of the body or another. Red blood cells are an important element of blood. Their job ... is carried to and eliminated by the lungs. Red blood cells are formed in the red bone marrow of ...

  3. Product service system product design task planning with supplier participation

    Directory of Open Access Journals (Sweden)

    Zhongqi Sheng

    2015-12-01

    Full Text Available Product service system is a new-type production system with high-degree integration and overall optimization of product and service. The participation of suppliers in product service system development will greatly shorten the development cycle and enhance the production efficiency. The task planning of product design is one of the key phases of product service system development process, which mainly contains the design task decomposition and the design task allocation. Aiming at product service system product design, this article conducts the decomposition of design tasks, performs the recognition of coupling design task set, and realizes the structured modeling of design tasks. Outsourcing decision-making analysis is conducted on the design tasks obtained through decomposition process so as to confirm the design tasks that need the participation of suppliers. The allocation model of design tasks is constructed, and the suppliers that take part in product service system development are confirmed based on genetic algorithm. Taking the numerical control machine tool as an example, this article conducts the instance analysis and verifies the feasibility of the forenamed methods.

  4. Quality cell therapy manufacturing by design.

    Science.gov (United States)

    Lipsitz, Yonatan Y; Timmins, Nicholas E; Zandstra, Peter W

    2016-04-01

    Transplantation of live cells as therapeutic agents is poised to offer new treatment options for a wide range of acute and chronic diseases. However, the biological complexity of cells has hampered the translation of laboratory-scale experiments into industrial processes for reliable, cost-effective manufacturing of cell-based therapies. We argue here that a solution to this challenge is to design cell manufacturing processes according to quality-by-design (QbD) principles. QbD integrates scientific knowledge and risk analysis into manufacturing process development and is already being adopted by the biopharmaceutical industry. Many opportunities to incorporate QbD into cell therapy manufacturing exist, although further technology development is required for full implementation. Linking measurable molecular and cellular characteristics of a cell population to final product quality through QbD is a crucial step in realizing the potential for cell therapies to transform healthcare.

  5. Product quality driven food process design

    OpenAIRE

    Hadiyanto, M.

    2007-01-01

    Consumers evaluate food products on their quality, and thus the product quality is a main target in industrial food production. In the last decade there has been a remarkable increase of interest of the food industry to put food product quality central in innovation. However, quality itself is seldom considered as a starting point for the design of production systems. The objective of this thesis is to advance food process innovation by procedures for food process design which start from the ...

  6. Towards a theory of product design specifications

    DEFF Research Database (Denmark)

    Hansen, Claus Thorp; Andreasen, Mogens Myrup

    2004-01-01

    The product design specification is an important element in a product development project because it defines the target to be met. One requirement on the product design specification is to articulate and communicate the aspects, which makes the product attractive seen from the users' viewpoint....... In the design methodology literature we find guidelines and methods to compile a product design specification. The contributions are based on the common underlying assumption that it is meaningful and the only feasible approach to interpret the result of a need analysis into a set of technical specifications......, which express the customers¿ need and perception of value. In this paper we will scrutinize this assumption. We outline the roles and tasks of the product design specification in order to identify the requirements on a theory of product design specifications and we identify existing theory elements...

  7. Fuzzy Design Method of Product Quality Robustness

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In order to express information on the quality grade of product, designed, the target value of product quality design was described with a fuzzy number in this paper. The rule of robust design with a fuzzy target was analyzed with fuzzy probability theory,then the principle and modeling method of fuzzy robust design for a high quality product were put forward. With this new method used, the high-quality ratio of the product de-signed could be increased, and the ability to resist the influence of various disturbing fac-tors ang noise factors could be enhanced.

  8. A grand model for chemical product design

    DEFF Research Database (Denmark)

    Fung, Ka Y.; Ng, Ka M.; Zhang, Lei;

    2016-01-01

    Chemical engineering has been expanding its focus from primarily business-to-business products (B2B) to business-to-consumer (B2C) products. The production of B2B products generally emphasizes on process design and optimization, whereas the production of B2C products focuses on product quality......, ingredients and structure. Market and competitive analysis, government policies and regulations have to be explicitly considered in product design. All these considerations are accounted for in the Grand Product Design Model, which consists of a process model, a property model, a quality model, a cost model...... product composition changes with market conditions. Another is a hand lotion that illustrates how product quality affects the profit.(C) 2016 Elsevier Ltd. All rights reserved....

  9. Advances in product family and product platform design methods & applications

    CERN Document Server

    Jiao, Jianxin; Siddique, Zahed; Hölttä-Otto, Katja

    2014-01-01

    Advances in Product Family and Product Platform Design: Methods & Applications highlights recent advances that have been made to support product family and product platform design and successful applications in industry. This book provides not only motivation for product family and product platform design—the “why” and “when” of platforming—but also methods and tools to support the design and development of families of products based on shared platforms—the “what”, “how”, and “where” of platforming. It begins with an overview of recent product family design research to introduce readers to the breadth of the topic and progresses to more detailed topics and design theory to help designers, engineers, and project managers plan, architect, and implement platform-based product development strategies in their companies. This book also: Presents state-of-the-art methods and tools for product family and product platform design Adopts an integrated, systems view on product family and pro...

  10. Personalised product design using virtual interactive techniques

    CERN Document Server

    Zacharia, Kurien; Varghese, Surekha Mariam

    2012-01-01

    Use of Virtual Interactive Techniques for personalized product design is described in this paper. Usually products are designed and built by considering general usage patterns and Prototyping is used to mimic the static or working behaviour of an actual product before manufacturing the product. The user does not have any control on the design of the product. Personalized design postpones design to a later stage. It allows for personalized selection of individual components by the user. This is implemented by displaying the individual components over a physical model constructed using Cardboard or Thermocol in the actual size and shape of the original product. The components of the equipment or product such as screen, buttons etc. are then projected using a projector connected to the computer into the physical model. Users can interact with the prototype like the original working equipment and they can select, shape, position the individual components displayed on the interaction panel using simple hand gestur...

  11. Production systems design : a product oriented approach and methodology

    OpenAIRE

    2008-01-01

    Production systems design is critical to achieving manufacturing performance and objectives. Although generic approaches to this design are available they may not be able to objectively address specific manufacturing configurations. Here it is argued that product oriented manufacturing (POM) organization offers advantages in relation to the function oriented one. Based on this, a methodology specially addressing POM systems design, and prototype of a Computer Aided Design Syste...

  12. PRODUCT DATA PREDICTION WITH UNCERTAINTY IN PRODUCT LIFE CYCLE DESIGN

    Institute of Scientific and Technical Information of China (English)

    Yu Suiran; Wang Chengtao; Kimura Fumihiko

    2003-01-01

    Various kinds of data are used in new product design and more accurate data make the design results more reliable. Even though part of product data can be available directly from the existing similar products, there still leaves a great deal of data unavailable. This makes data prediction a valuable work. A method that can predict data of product under development based on the existing similar products is proposed. Fuzzy theory is used to deal with the uncertainties in data prediction process. The proposed method can be used in life cycle design, life cycle assessment (LCA) etc. Case study on current refrigerator is used as a demonstration example.

  13. Communication Strategies and Product Line Design

    OpenAIRE

    J. Miguel Villas-Boas

    2004-01-01

    When selling a product line, a firm has to consider the costs of communicating about the different products to the consumers. This may affect the product line design in general, and which products or services are offered in particular. The problem is that firms have to communicate to consumers, possibly through advertising, to make them consider buying the products that firms are selling. This results in the firm offering a smaller number of products than is optimal when advertising has no co...

  14. Engineering Changes in Product Design - A Review

    Science.gov (United States)

    Karthik, K.; Janardhan Reddy, K., Dr

    2016-09-01

    Changes are fundamental to product development. Engineering changes are unavoidable and can arise at any phase of the product life cycle. The consideration of market requirements, customer/user feedbacks, manufacturing constraints, design innovations etc., turning them into viable products can be accomplished when product change is managed properly. In the early design cycle, informal changes are accepted. However, changes become formal when its complexity and cost increases, and as product matures. To maximize the market shares, manufacturers have to effectively and efficiently manage engineering changes by means of Configuration Control. The paper gives a broad overview about ‘Engineering Change Management’ (ECM) through configuration management and its implications in product design. The aim is to give an idea and understanding about the engineering changes in product design scenario to the new researchers. This paper elaborates the significant aspect of managing the engineering changes and the importance of ECM in a product life cycle.

  15. Design for the Environment Products (Raw Data)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains a list of products that carry the Design for the Environment (DfE) label. This mark enables consumers to quickly identify and choose products...

  16. Design for the Environment Products (Online Search)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains a list of products that carry the Design for the Environment (DfE) label. This mark enables consumers to quickly identify and choose products...

  17. Cost Decision Support in Product Design

    NARCIS (Netherlands)

    Liebers, A.; Kals, H.J.J.

    1997-01-01

    The constraints addressed in decision making during product design, process planning and production planning determine the admissible solution space for the manufacture of products. The solution space determines largely the costs that are incurred in the production process. In order to be able to ma

  18. Analysis“aesthetic”influence product design

    Institute of Scientific and Technical Information of China (English)

    闫丽娜

    2014-01-01

    Product modelling the restraint of aesthetic, the different of the consumer's aesthetic are affecting the exterior of the product, through the paper analyses the aesthetic standards of consumers and the development trend of beauty is determined. The aesthetic vieweffect of product modeling, The porcelain as an example, compared with traditional aesthetics and modern aesthetics, then design different modeling of products.

  19. Design Review Improvements Product Overview

    Science.gov (United States)

    2015-05-07

    Boeing Anne Ramsey, Harris Corporation Ronald H. Mandel, Lockheed Martin Mark King, Micropac Industries Melanie Berg , NASA Cindy Kohlmiller...Improvements Topic • Design escapes continue to impact program cost, schedule and mission performance • Our design review and development test programs...for and conduct design reviews – Surveyed team member companies – 49 test cases – Reviewed Aerospace on-orbit anomaly data (Classified) – 121 test cases

  20. New product development using experimental design

    OpenAIRE

    Zhang, Zhihai

    1998-01-01

    New product development is one of the most powerful but difficult activities in business. It is also a very important factor affecting final product quality. There are many techniques available for new product development. Experimental design is now regarded as one of the most significant techniques. In this article, we will discuss how to use the technique of experimental design in developing a new product - an extrusion press. In order to provide a better understanding of this specific proc...

  1. Product Design Engineering--A Global Education Trend in Multidisciplinary Training for Creative Product Design

    Science.gov (United States)

    de Vere, Ian; Melles, Gavin; Kapoor, Ajay

    2010-01-01

    Product design is the convergence point for engineering and design thinking and practices. Until recently, product design has been taught either as a component of mechanical engineering or as a subject within design schools but increasingly there is global recognition of the need for greater synergies between industrial design and engineering…

  2. Method and apparatus for product design evaluation

    NARCIS (Netherlands)

    Saakes, D.P.

    2008-01-01

    The invention relates to a method for product design evaluation that comprises - providing a model of a product design to be developed, and - with the aid of light beams projecting a material and/or pattern or a colour image onto the model, wherein the model is placed on a worktop and that during th

  3. Design of experiments in production engineering

    CERN Document Server

    2016-01-01

    This book covers design of experiments (DoE) applied in production engineering as a combination of manufacturing technology with applied management science. It presents recent research advances and applications of design experiments in production engineering and the chapters cover metal cutting tools, soft computing for modelling and optmization of machining, waterjet machining of high performance ceramics, among others.

  4. Insights Gained from Testing Alternate Cell Designs

    Energy Technology Data Exchange (ETDEWEB)

    J. E. O' Brien; C. M. Stoots; J. S. Herring; G. K. Housley; M. S. Sohal; D. G. Milobar; Thomas Cable

    2009-09-01

    The Idaho National Laboratory (INL) has been researching the application of solid-oxide electrolysis cell for large-scale hydrogen production from steam over a temperature range of 800 to 900ºC. The INL has been testing various solid oxide cell designs to characterize their electrolytic performance operating in the electrolysis mode for hydrogen production. Some results presented in this report were obtained from cells, initially developed by the Forschungszentrum Jülich and now manufactured by the French ceramics firm St. Gobain. These cells have an active area of 16 cm2 per cell. They were initially developed as fuel cells, but are being tested as electrolytic cells in the INL test stands. The electrolysis cells are electrode-supported, with ~10 µm thick yttria-stabilized zirconia (YSZ) electrolytes, ~1400 µm thick nickel-YSZ steam-hydrogen electrodes, and manganite (LSM) air-oxygen electrodes. The experiments were performed over a range of steam inlet mole fractions (0.1 to 0.6), gas flow rates, and current densities (0 to 0.6 A/cm2). Steam consumption rates associated with electrolysis were measured directly using inlet and outlet dewpoint instrumentation. On a molar basis, the steam consumption rate is equal to the hydrogen production rate. Cell performance was evaluated by performing DC potential sweeps at 800, 850, and 900°C. The voltage-current characteristics are presented, along with values of area-specific resistance as a function of current density. Long-term cell performance is also assessed to evaluate cell degradation. Details of the custom single-cell test apparatus developed for these experiments are also presented. NASA, in conjunction with the University of Toledo, has developed another fuel cell concept with the goals of reduced weight and high power density. The NASA cell is structurally symmetrical, with both electrodes supporting the thin electrolyte and containing micro-channels for gas diffusion. This configuration is called a bi

  5. Product design, semantics and emotional response.

    Science.gov (United States)

    Demirbilek, Oya; Sener, Bahar

    This paper explores theoretical issues in ergonomics related to semantics and the emotional content of design. The aim is to find answers to the following questions: how to design products triggering "happiness" in one's mind; which product attributes help in the communication of positive emotions; and finally, how to evoke such emotions through a product. In other words, this is an investigation of the "meaning" that could be designed into a product in order to "communicate" with the user at an emotional level. A literature survey of recent design trends, based on selected examples of product designs and semantic applications to design, including the results of recent design awards, was carried out in order to determine the common attributes of their design language. A review of Good Design Award winning products that are said to convey and/or evoke emotions in the users has been done in order to define good design criteria. These criteria have been discussed in relation to user emotional responses and a selection of these has been given as examples.

  6. Integrating product design into the supply chain

    DEFF Research Database (Denmark)

    Khan, Omera; Stolte, Terje; Creazza, Alessandro

    2016-01-01

    of opportunities and challenges when integrating product design and the supply chain and subsequently a step-by-step guide is developed to address these. Practical Implications: The research provides key recommendations to companies on how to create competitive capabilities by integrating product design...... into the supply chain. Originality/Value: This paper provides novel insights to both practitioners and researchers. For practitioners detailed recommendations are given on how they can maximise benefits through integrating product design into the supply chain. The RBV has been harnessed to highlight how......Purpose: The aim of the research is to illustrate how companies can create competitive capabilities through integration of product design into the supply chain. In doing so the paper reveals the challenges and the opportunities that companies face when integrating product design and supply chain...

  7. Production System Design for Multiple Brands

    DEFF Research Database (Denmark)

    Karlsson, Christer; Christensen, Irene

    appliances, cars, and trucks but also other products. An important denominator for the production system design is flow structures. Important dependent factors come from brand distinction, architectural characteristics, technology levels, supplier competence, process choice, process flow patterns, lay......-outs, worker skills, integration of distribution channels, after sales service and degree of servitization. Three production system design principles called VXY emerge.......Production systems enabling both cost efficiency and flexibility in terms of high product variation are explored. The study follows an explorative longitudinal field study approach. The database consists of three large global corporations, each consisting of several companies producing household...

  8. Product model structure for generalized optimal design

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The framework of the generalized optimization product model with the core of network- and tree-hierarchical structure is advanced to improve the characteristics of the generalized optimal design. Based on the proposed node-repetition technique, a network-hierarchical structure is united with the tree-hierarchical structure to facilitate the modeling of serialization and combination products. The criteria for product decomposition are investigated. Seven tree nodes are defined for the construction of a general product model, and their modeling properties are studied in detail. The developed product modeling system is applied and examined successfully in the modeling practice of the generalized optimal design for a hydraulic excavator.

  9. New product development using experimental design

    NARCIS (Netherlands)

    Zhang, Zhihai

    1998-01-01

    New product development is one of the most powerful but difficult activities in business. It is also a very important factor affecting final product quality. There are many techniques available for new product development. Experimental design is now regarded as one of the most significant techniques

  10. Tools and techniques for product design

    NARCIS (Netherlands)

    Lutters, Eric; Houten, Fred J.A.M.; Bernard, Alain; Mermoz, Emmanuel; Schutte, Corné S.L.

    2014-01-01

    For product designers, tools and techniques are essential in driving the design cycle. Nevertheless, their employment usually is implicit, while passing over e.g. the design and project environments empowering their adequate use. This publication presents an overview of approaches in structuring and

  11. Tris-sucrose buffer system: a new specially designed medium for extracellular invertase production by immobilized cells of isolated yeast Cryptococcus laurentii MT-61.

    Science.gov (United States)

    Aydogan, Mehmet Nuri; Taskin, Mesut; Canli, Ozden; Arslan, Nazli Pinar; Ortucu, Serkan

    2014-01-01

    The aims of the present study were to isolate new yeasts with high extracellular (exo) invertase activity and to investigate the usability of buffer systems as invertase production media by immobilized yeast cells. Among 70 yeast isolates, Cryptococcus laurentii MT-61 had the highest exo-invertase activity. Immobilization of yeast cells was performed using sodium alginate. Higher exo-invertase activity for immobilized cells was achieved in tris-sucrose buffer system (TSBS) compared to sodium acetate buffer system and potassium phosphate buffer system. TSBS was prepared by dissolving 30 g of sucrose in 1 L of tris buffer solution. The optimum pH, temperature, and incubation time for invertase production with immobilized cells were determined as 8.0, 35 °C and 36 h in TSBS, respectively. Under optimized conditions, maximum exo-invertase activity was found to be 28.4 U/mL in sterile and nonsterile TSBS. Immobilized cells could be reused in 14 and 12 successive cycles in sterile and nonsterile TSBS without any loss in the maximum invertase activity, respectively. This is the first report which showed that immobilized microbial cells could be used as a biocatalyst for exo-invertase production in buffer system. As an additional contribution, a new yeast strain with high invertase activity was isolated.

  12. Design of formulated products: a systematic methodology

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul; Ng, K.M.

    2011-01-01

    -based computer-aided methodology for design and verification of a class of chemical-based products (liquid formulations) is presented. This methodology is part of an integrated three-stage approach for design/verification of liquid formulations where stage-1 generates a list of feasible product candidates and....../or verifies a specified set through a sequence of predefined activities (work-flow). Stage-2 and stage-3 (not presented here) deal with the planning and execution of experiments, for product validation. Four case studies have been developed to test the methodology. The computer-aided design (stage-1...

  13. Conceptual frames for changing production system design

    DEFF Research Database (Denmark)

    Jensen, Per Langå; Broberg, Ole

    2003-01-01

    In order to integrate ergonomic aspects into the design of products and production systems many tools and procedures are available. For the ergonomists, however, it is a question of recognizing the organizational context and the role to play for making integration possible. Based on an understand......In order to integrate ergonomic aspects into the design of products and production systems many tools and procedures are available. For the ergonomists, however, it is a question of recognizing the organizational context and the role to play for making integration possible. Based...

  14. The marketing implications of affective product design.

    Science.gov (United States)

    Seva, Rosemary R; Duh, Henry Been-Lirn; Helander, Martin G

    2007-11-01

    Emotions are compelling human experiences and product designers can take advantage of this by conceptualizing emotion-engendering products that sell well in the market. This study hypothesized that product attributes influence users' emotions and that the relationship is moderated by the adherence of these product attributes to purchase criteria. It was further hypothesized that the emotional experience of the user influences purchase intention. A laboratory study was conducted to validate the hypotheses using mobile phones as test products. Sixty-two participants were asked to assess eight phones from a display of 10 phones and indicate their emotional experiences after assessment. Results suggest that some product attributes can cause intense emotional experience. The attributes relate to the phone's dimensions and the relationship between these dimensions. The study validated the notion of integrating affect in designing products that convey users' personalities.

  15. The Virtual Product-Process Design Laboratory for Structured Chemical Product Design and Analysis

    DEFF Research Database (Denmark)

    Mattei, Michele; Yunus, Nor Alafiza Binti; Kalakul, Sawitree;

    2014-01-01

    The objective of this paper is to present new methods for design of chemicals based formulated products and their implementation in the software, the Virtual Product-Process Design Laboratory. The new products are tailor-made blended liquid products and emulsion-based products. The new software...... employs a template approach, where each template follows the same common steps in the workflow for design of formulated products, but has the option to employ different product specific property models, data and calculation routines, when necessary. With the new additions, the software is able to support...... the design and analysis of a wide range of homogeneous formulated products: tailor-made blends, single phase liquid formulations and emulsion-based products. The decision making process is supported by dedicated property models and structured databases, specifically developed for each design problem scenario...

  16. Towards Generic Interaction Styles for Product Design

    DEFF Research Database (Denmark)

    Buur, Jacob; Stienstra, Marcelle

    2008-01-01

    A growing uneasiness among users with the experience of current product user interfaces mounts pressure on interaction designers to innovate user interface conventions. In previous research we have shown that a study of the history of product interaction triggers a broader discussion of interaction...... qualities among designers in a team, and that the naming of interaction styles helps establish an aesthetics of interaction design. However, that research focused on one particular product field, namely industrial controllers, and it was yet to be proven, if interaction styles do have generic traits across...... a wider range of interactive products. In this paper we report on five years of continued research into interaction styles for telephones, kitchen equipment, HiFi products and medical devices, and we show how it is indeed possible and beneficial to formulate a set of generic interaction styles....

  17. Haptics for Product Design and Manufacturing Simulation.

    Science.gov (United States)

    Xia, Pingjun

    2016-01-01

    Product design and manufacturing simulation is a promising research and application area for haptics. By benefiting from its natural human-computer interaction and realistic force/torque feedback, haptics can change the traditional design and manufacturing approaches which are mainly based on physical mock-ups or CAD (Computer Aided Design) modes. This paper provides a detailed and comprehensive survey of haptics for product design and manufacturing simulation in the past 10 years, mainly from 2004-2014, including haptics for product design and shape modelling, haptics for machining simulation, and haptics for virtual assembly and maintenance simulation. The new haptic devices and rendering algorithms involved in this area are introduced, the major research efforts and the typical systems are discussed, and the new ideas and research progresses are investigated. Then, conclusions and future trends are summarized.

  18. New design competences for localized production systems

    DEFF Research Database (Denmark)

    Eriksen, Kaare Riise; Morelli, Nicola

    2005-01-01

    This paper discusses the current development in production culture, based on local production networks. The role of the designer is put in perspective and outlined through a research project, Den Grønne Møbel (DGM), where different design areas were coordinated in a business concept...... and an organization involving different stakeholders. For several years now, DGM has been producing furniture from local materials, hereby aiming to create a new culture for well designed and environmentally sound furniture with a ‘story’. Although not totally new, this organizational model is particularly innovative...... in fully industrialized countries such as Denmark and represents an interesting alternative to globalized industrial production. Furthermore this case is an interesting opportunity to re-discuss the role and competences of designers in such new models. Tools and methods of the design profession...

  19. An Optimization Framework for Product Design

    OpenAIRE

    Leyuan Shi; Sigurdur Ólafsson; Qun Chen

    2001-01-01

    An important problem in the product design and development process is to use the part-worths preferences of potential customers to design a new product such that market share is maximized. The authors present a new optimization framework for this problem, the nested partitions (NP) method. This method is globally convergent and may utilize existing heuristic methods to speed its convergence. We incorporate several known heuristics into this framework and demonstrate through numerical experime...

  20. Product modular design incorporating preventive maintenance issues

    Science.gov (United States)

    Gao, Yicong; Feng, Yixiong; Tan, Jianrong

    2016-03-01

    Traditional modular design methods lead to product maintenance problems, because the module form of a system is created according to either the function requirements or the manufacturing considerations. For solving these problems, a new modular design method is proposed with the considerations of not only the traditional function related attributes, but also the maintenance related ones. First, modularity parameters and modularity scenarios for product modularity are defined. Then the reliability and economic assessment models of product modularity strategies are formulated with the introduction of the effective working age of modules. A mathematical model used to evaluate the difference among the modules of the product so that the optimal module of the product can be established. After that, a multi-objective optimization problem based on metrics for preventive maintenance interval different degrees and preventive maintenance economics is formulated for modular optimization. Multi-objective GA is utilized to rapidly approximate the Pareto set of optimal modularity strategy trade-offs between preventive maintenance cost and preventive maintenance interval difference degree. Finally, a coordinate CNC boring machine is adopted to depict the process of product modularity. In addition, two factorial design experiments based on the modularity parameters are constructed and analyzed. These experiments investigate the impacts of these parameters on the optimal modularity strategies and the structure of module. The research proposes a new modular design method, which may help to improve the maintainability of product in modular design.

  1. Product Modular Design Incorporating Preventive Maintenance Issues

    Institute of Scientific and Technical Information of China (English)

    GAO Yicong; FENG Yixiong; TAN Jianrong

    2016-01-01

    Traditional modular design methods lead to product maintenance problems, because the module form of a system is created according to either the function requirements or the manufacturing considerations. For solving these problems, a new modular design method is proposed with the considerations of not only the traditional function related attributes, but also the maintenance related ones. First, modularity parameters and modularity scenarios for product modularity are defined. Then the reliability and economic assessment models of product modularity strategies are formulated with the introduction of the effective working age of modules. A mathematical model used to evaluate the difference among the modules of the product so that the optimal module of the product can be established. After that, a multi-objective optimization problem based on metrics for preventive maintenance interval different degrees and preventive maintenance economics is formulated for modular optimization. Multi-objective GA is utilized to rapidly approximate the Pareto set of optimal modularity strategy trade-offs between preventive maintenance cost and preventive maintenance interval difference degree. Finally, a coordinate CNC boring machine is adopted to depict the process of product modularity. In addition, two factorial design experiments based on the modularity parameters are constructed and analyzed. These experiments investigate the impacts of these parameters on the optimal modularity strategies and the structure of module. The research proposes a new modular design method, which may help to improve the maintainability of product in modular design.

  2. Greenelec: Product design linked to recycling

    NARCIS (Netherlands)

    Balkenende, R.; Occhionorelli, V.; Van Meensel, W.; Felix, J.; Sjölin, S.; Aerts, M.; Huisman, J.; Becker, J.; Van Schaik, A.; Reuter, M.

    2014-01-01

    GreenElec aims to significantly improve on the resource efficiency of electronics and electronic products. This is accomplished by close cooperation between manufacturers and recyclers. Design guidelines for improved recycling have been formulated and products (lamps and displays) have been redesign

  3. MECHANICAL PRODUCT EXTENSIVE INTELLIGENT CONCEPTUAL DESIGN

    Institute of Scientific and Technical Information of China (English)

    Zhang Guoquan; Zhong Yifang; Zhang Weiguo

    2004-01-01

    Based on extenics, an extensive functional information model (function-behavioral action-structure-environmental constraint) of the mechanical product intelligent conceptual design is developed, and the mechanism of theoretic structure solutions is produced, the mapping relations between function-behavior and behavior-structure are analyzed.The model is applied to the filling material system's conceptual design to verify validity.

  4. Lowlands sociotechnical design theory and lean production

    NARCIS (Netherlands)

    Christis, Jac; Soepenberg, Erik

    2015-01-01

    Lean Production (LP) can be regarded as a design approach in search of a theoretical foundation. In this paper we show that Lowlands’ Sociotechnical Design Theory (STSL) could function as such a foundation. To reach this goal, we first describe STSL as a system theoretical reformulation of Original

  5. Health and Welfare IT Product Design

    DEFF Research Database (Denmark)

    Merritt, Timothy; Grønbæk, Kaj

    2012-01-01

    finding a suitable problem to solve, iterating and refining their designs, evaluating prototypes with users, and finally presenting their work as a potential product with a detailed plan for how the product would be sold in the market. The primary contribution of this paper is to share innovative design......In this paper we describe the outcomes from a university design class focused on the design of systems intended to solve problems faced by health care professionals, patients and systems that support welfare or extended independence for older people. The students worked in groups for 10 weeks...... ideas with the design community and to reflect on lessons learned by the students who, for the first time, were designing robust prototypes that solve real world problems....

  6. Bioreactor design for photofermentative hydrogen production.

    Science.gov (United States)

    Uyar, Basar

    2016-09-01

    Hydrogen will become a significant fuel in the near future. Photofermentative production of hydrogen is a promising and sustainable process. The design, construction and successful operation of the photobioreactors are of critical importance for photofermentative hydrogen production and became a major field of research where novel technologies are developed and adapted frequently. This paper gives an overview of the design aspects related to photobioreactors giving particular attention to design limitations, construction material, type, operating mode and scale-up. Sub-components of the overall system setup such as mixing, temperature control and hydrogen collection are also discussed. Recent achievements in the photobioreactor technologies are described.

  7. Soft and hard product attributes in design

    DEFF Research Database (Denmark)

    Lenau, Torben Anker; Boelskifte, Per

    2003-01-01

    , business and engineering) showed consensus on assigning certain words to specific products in order to express the sensory and perceived experiences (Johnson et al. 2003). An initial vocabulary was formulated based on input from the design literature. The study showed that a significant amount of the test......Products are to a growing extend being sold based on their soft values such as design and styling and the image they can bring the owner. This makes it more important that people involved in product development can communicate these more soft or intangible values. Works within this area is pursued...... a number of places (Lopez 2003, Pascalle 2000, Goovers 2003, Warell 2001). The authors have experienced the need when searching for materials that can give the product a certain expression (www.designinsite.dk). In a previous study an interdisciplinary group of 14 students (coming from industrial design...

  8. [Strategic considerations on the design and choice of animal models for non-clinical investigations of cell-based medicinal products].

    Science.gov (United States)

    Lehmann, Jörg; Schulz, Ronny M; Sanzenbacher, Ralf

    2015-11-01

    For the development of medicinal products animal models are still indispensable to demonstrate efficacy and safety prior to first use in humans. Advanced therapy medicinal products (ATMP), which include cell-based medicinal products (CBMP), differ in their pharmacology and toxicology compared to conventional pharmaceuticals, and thus, require an adapted regime for non-clinical development. Developers are, therefore, challenged to develop particular individual concepts and to reconcile these with regulatory agencies. Guidelines issued by the European Medicines Agency (EMA), the U.S. Food and Drug Administration (FDA) and other sources can provide direction.The published approaches for non-clinical testing of efficacy document that homologous animal models where the therapeutic effect is investigated in a disease-relevant animal model utilizing cells derived from the same species are commonly used. The challenge is that the selected model should reflect the human disease in all critical features and that the cells should be comparable to the investigated human medicinal product in terms of quality and biological activity. This is not achievable in all cases. In these cases, alternative methods may provide supplemental information. To demonstrate the scientific proof-of-concept (PoC), small animal models such as mice or rats are preferred. During the subsequent product development phase, large animal models (i.e. sheep, minipigs, dogs) must be considered, as they may better reflect the anatomical or physiological situation in humans. In addition to efficacy, those models may also be suitable to prove some safety aspects of ATMP (e.g. regarding dose finding, local tolerance, or undesired interactions and effects of the administered cells in the target tissue). In contrast, for evaluation of the two prominent endpoints for characterizing the safety of ATMP (i.e. biodistribution, tumorigenicity) heterologous small animal models, especially immunodeficient mouse strains

  9. Bioreactor and process design for biohydrogen production.

    Science.gov (United States)

    Show, Kuan-Yeow; Lee, Duu-Jong; Chang, Jo-Shu

    2011-09-01

    Biohydrogen is regarded as an attractive future clean energy carrier due to its high energy content and environmental-friendly conversion. It has the potential for renewable biofuel to replace current hydrogen production which rely heavily on fossil fuels. While biohydrogen production is still in the early stage of development, there have been a variety of laboratory- and pilot-scale systems developed with promising potential. This work presents a review of advances in bioreactor and bioprocess design for biohydrogen production. The state-of-the art of biohydrogen production is discussed emphasizing on production pathways, factors affecting biohydrogen production, as well as bioreactor configuration and operation. Challenges and prospects of biohydrogen production are also outlined.

  10. Establishing elements of a synthetic biology platform for Vaccinia virus production: BioBrick™ design, serum-free virus production and microcarrier-based cultivation of CV-1 cells.

    Science.gov (United States)

    Liu, Shuchang; Ruban, Ludmila; Wang, Yaohe; Zhou, Yuhong; Nesbeth, Darren N

    2017-02-01

    Vaccinia virus (VACV) is an established vector for vaccination and is beginning to prove effective as an oncolytic agent. Industrial production of VACV stands to benefit in future from advances made by synthetic biology in genome engineering and standardisation. The CV-1 cell line can be used for VACV propagation and has been used extensively with the CRISPR/Cas9 system for making precise edits of the VACV genome. Here we take first steps toward establishing a scalable synthetic biology platform for VACV production with CV-1 cells featuring standardised biological tools and serum free cell cultivation. We propose a new BioBrick™ plasmid backbone format for inserting transgenes into VACV. We then test the performance of CV-1 cells in propagation of a conventional recombinant Lister strain VACV, VACVL-15 RFP, in a serum-free process. CV-1 cells grown in 5% foetal bovine serum (FBS) Dulbecco's Modified Eagle Medium (DMEM) were adapted to growth in OptiPRO and VP-SFM brands of serum-free media. Specific growth rates of 0.047 h(-1) and 0.044 h(-1) were observed for cells adapted to OptiPRO and VP-SFM respectively, compared to 0.035 h(-1) in 5% FBS DMEM. Cells adapted to OptiPRO and to 5% FBS DMEM achieved recovery ratios of over 96%, an indication of their robustness to cryopreservation. Cells adapted to VP-SFM showed a recovery ratio of 82%. Virus productivity in static culture, measured as plaque forming units (PFU) per propagator cell, was 75 PFU/cell for cells in 5% FBS DMEM. VP-SFM and OptiPRO adaptation increased VACV production to 150 PFU/cell and 350 PFU/cell respectively. Boosted PFU/cell from OptiPRO-adapted cells persisted when 5% FBS DMEM or OptiPRO medium was observed during the infection step and when titre was measured using cells adapted to 5% FBS DMEM or OptiPRO medium. Finally, OptiPRO-adapted CV-1 cells were successfully cultivated using Cytodex-1 microcarriers to inform future scale up studies.

  11. Safety in the design of production lines

    DEFF Research Database (Denmark)

    Dyhrberg, Mette Bang; Broberg, Ole; Jacobsen, Peter

    2006-01-01

    This paper is a case study report on how safety considerations were handled in the process of redesigning a production line. The design process was characterized as a specification and negotiation process between engineers from the company and the supplier organization. The new production line...... became safer, but not as a result of any intentional plan to integrate safety aspects into the design process. Instead, the supplier’s design of a new piece of equipment had a higher built-in safety level. The engineering team in the company was aware of the importance of safety aspects neither...... a ‘history workshop’ with the engineering team. The workshop clarified the sequence of events and discussions that took place during the design process and opened for a discussion of the role of safety aspects. During the workshop new insights emerged into the question of how to integrate safety aspects...

  12. An optimisation method for complex product design

    Science.gov (United States)

    Li, Ni; Yi, Wenqing; Bi, Zhuming; Kong, Haipeng; Gong, Guanghong

    2013-11-01

    Designing a complex product such as an aircraft usually requires both qualitative and quantitative data and reasoning. To assist the design process, a critical issue is how to represent qualitative data and utilise it in the optimisation. In this study, a new method is proposed for the optimal design of complex products: to make the full use of available data, information and knowledge, qualitative reasoning is integrated into the optimisation process. The transformation and fusion of qualitative and qualitative data are achieved via the fuzzy sets theory and a cloud model. To shorten the design process, parallel computing is implemented to solve the formulated optimisation problems. A parallel adaptive hybrid algorithm (PAHA) has been proposed. The performance of the new algorithm has been verified by a comparison with the results from PAHA and two other existing algorithms. Further, PAHA has been applied to determine the shape parameters of an aircraft model for aerodynamic optimisation purpose.

  13. Production engineering jig and tool design

    CERN Document Server

    Jones, E J H

    1972-01-01

    Production Engineering: Jig and Tool Design focuses on jig and tool design as part of production engineering and covers topics ranging from inspection and gauging to multiple and consecutive tooling, tool calculation and development of form tools, deep-hole boring, and grinding-wheel form-crushing. Air and oil operated fixtures, negative rake machining, and the economics of jig and fixture practice are also discussed. This text is comprised of 22 chapters; the first of which provides an overview of the function and organization of the jig and tool department. Attention then turns to the subjec

  14. Effects of Polyhydroxybutyrate Production on Cell Division

    Science.gov (United States)

    Miller, Kathleen; Rahman, Asif; Hadi, Masood Z.

    2015-01-01

    Synthetic biological engineering can be utilized to aide the advancement of improved long-term space flight. The potential to use synthetic biology as a platform to biomanufacture desired equipment on demand using the three dimensional (3D) printer on the International Space Station (ISS) gives long-term NASA missions the flexibility to produce materials as needed on site. Polyhydroxybutyrates (PHBs) are biodegradable, have properties similar to plastics, and can be produced in Escherichia coli using genetic engineering. Using PHBs during space flight could assist mission success by providing a valuable source of biomaterials that can have many potential applications, particularly through 3D printing. It is well documented that during PHB production E. coli cells can become significantly elongated. The elongation of cells reduces the ability of the cells to divide and thus to produce PHB. I aim to better understand cell division during PHB production, through the design, building, and testing of synthetic biological circuits, and identify how to potentially increase yields of PHB with FtsZ overexpression, the gene responsible for cell division. Ultimately, an increase in the yield will allow more products to be created using the 3D printer on the ISS and beyond, thus aiding astronauts in their missions.

  15. Design, product structuring and modelling of mechatronic products and systems

    DEFF Research Database (Denmark)

    Conrad, Finn; Sørensen, Torben

    2003-01-01

    Information Technology offers software and hardware for improvement of the engineering design, structuring and control systems, and industrial applications. The latest progress in IT makes integration of an overall design and manufacturing IT- concept feasible and commercially attractive. An IT......-tool concept for modelling, simulation and design of mechatronic products and systems is proposed in this paper. It built on results from a Danish mechatronic research program on intelligent motion control as well as from the Esprit project SWING on IT-tools for rapid prototyping of fluid power components...

  16. Sensory Marketing:Designing Pleasurable Products

    Institute of Scientific and Technical Information of China (English)

    Lageat Thierry

    2004-01-01

    Luxury products, household appliances, cosmetics and products for the general public all use the techniques of sensory marketing in the very first phases of conception to specify or give a distinct character to the way they are perceived. Creating the visio-tactile qualities of a mobile phone or dashboard, designing the acoustics used in a lipstick tube closure: these considerations offer industry a way of managing and mastering the sensorial identity which will set their products apart from those of their competitors. Sensory marketing is based upon the objective definition, the analysis and the mastering of the qualitative characteristics of the object to be conceived.

  17. Counting on natural products for drug design

    Science.gov (United States)

    Rodrigues, Tiago; Reker, Daniel; Schneider, Petra; Schneider, Gisbert

    2016-06-01

    Natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Recently, there has been a revitalization of interest in the inclusion of these chemotypes in compound collections for screening and achieving selective target modulation. Here we discuss natural-product-inspired drug discovery with a focus on recent advances in the design of synthetically tractable small molecules that mimic nature's chemistry. We highlight the potential of innovative computational tools in processing structurally complex natural products to predict their macromolecular targets and attempt to forecast the role that natural-product-derived fragments and fragment-like natural products will play in next-generation drug discovery.

  18. Design of environmentally friendly products using indicators

    DEFF Research Database (Denmark)

    Lenau, Torben Anker; Bey, Niki

    2001-01-01

    The paper describes the requirements of product designers towards methods for environmental evaluation; it argues that indicators can be used for rough environmental evaluations and it presents experiences made with the indicator-based Oil Point Method (OPM). This method is illustrated by means...

  19. Production of oncolytic adenovirus and human mesenchymal stem cells in a single-use, Vertical-Wheel bioreactor system: Impact of bioreactor design on performance of microcarrier-based cell culture processes.

    Science.gov (United States)

    Sousa, Marcos F Q; Silva, Marta M; Giroux, Daniel; Hashimura, Yas; Wesselschmidt, Robin; Lee, Brian; Roldão, António; Carrondo, Manuel J T; Alves, Paula M; Serra, Margarida

    2015-01-01

    Anchorage-dependent cell cultures are used for the production of viruses, viral vectors, and vaccines, as well as for various cell therapies and tissue engineering applications. Most of these applications currently rely on planar technologies for the generation of biological products. However, as new cell therapy product candidates move from clinical trials towards potential commercialization, planar platforms have proven to be inadequate to meet large-scale manufacturing demand. Therefore, a new scalable platform for culturing anchorage-dependent cells at high cell volumetric concentrations is urgently needed. One promising solution is to grow cells on microcarriers suspended in single-use bioreactors. Toward this goal, a novel bioreactor system utilizing an innovative Vertical-Wheel™ technology was evaluated for its potential to support scalable cell culture process development. Two anchorage-dependent human cell types were used: human lung carcinoma cells (A549 cell line) and human bone marrow-derived mesenchymal stem cells (hMSC). Key hydrodynamic parameters such as power input, mixing time, Kolmogorov length scale, and shear stress were estimated. The performance of Vertical-Wheel bioreactors (PBS-VW) was then evaluated for A549 cell growth and oncolytic adenovirus type 5 production as well as for hMSC expansion. Regarding the first cell model, higher cell growth and number of infectious viruses per cell were achieved when compared with stirred tank (ST) bioreactors. For the hMSC model, although higher percentages of proliferative cells could be reached in the PBS-VW compared with ST bioreactors, no significant differences in the cell volumetric concentration and expansion factor were observed. Noteworthy, the hMSC population generated in the PBS-VW showed a significantly lower percentage of apoptotic cells as well as reduced levels of HLA-DR positive cells. Overall, these results showed that process transfer from ST bioreactor to PBS-VW, and scale-up was

  20. Digital Production and Students as Learning Designers

    DEFF Research Database (Denmark)

    Sørensen, Birgitte Holm; Levinsen, Karin

    2014-01-01

    Today’s digitalization allows users to interact, collaborate, communicate and create user-generated content. The technology is intuitive and easy to use even for young children, and new learning opportunities emerge. Particularly, students’ production as a learning form benefits from digitalization...... as the new opportunities enable young students to integrate their playing competencies and skills into the formal school learning. This paper presents and discusses a theory regarding students’ digital production from a learning and design-for-learning perspective, which is generated based on the project...... Netbook 1:1 (2009–2012), where information and communication technology (ICT) was readily accessible for each child at school and at home in grades 1–3 at two Danish public schools. The paper presents a Four Levels Design for Learning Model, which can be used for both design for learning and analyses...

  1. Product design engineering - a global education trend in multidisciplinary training for creative product design

    Science.gov (United States)

    de Vere, Ian; Melles, Gavin; Kapoor, Ajay

    2010-03-01

    Product design is the convergence point for engineering and design thinking and practices. Until recently, product design has been taught either as a component of mechanical engineering or as a subject within design schools but increasingly there is global recognition of the need for greater synergies between industrial design and engineering training. Product design engineering (PDE) is a new interdisciplinary programme combining the strengths of the industrial design and engineering. This paper examines the emergence of PDE in an environment of critique of conventional engineering education and exemplifies the current spread of programmes endorsing a hybrid programme of design and engineering skills. The paper exemplifies PDE with the analysis of the programme offered at Swinburne University of Technology (Australia), showing how the teaching of 'designerly' thinking to engineers produces a new graduate particularly suited to the current and future environment of produce design practice. The paper concludes with reflections on the significance of this innovative curriculum model for the field of product design and for engineering design in general.

  2. Kinetics of virus production from single cells.

    Science.gov (United States)

    Timm, Andrea; Yin, John

    2012-03-01

    The production of virus by infected cells is an essential process for the spread and persistence of viral diseases, the effectiveness of live-viral vaccines, and the manufacture of viruses for diverse applications. Yet despite its importance, methods to precisely measure virus production from cells are lacking. Most methods test infected-cell populations, masking how individual cells behave. Here we measured the kinetics of virus production from single cells. We combined simple steps of liquid-phase infection, serial dilution, centrifugation, and harvesting, without specialized equipment, to track the production of virus particles from BHK cells infected with vesicular stomatitis virus. Remarkably, cell-to-cell differences in latent times to virus release were within a factor of two, while production rates and virus yields spanned over 300-fold, highlighting an extreme diversity in virus production for cells from the same population. These findings have fundamental and technological implications for health and disease.

  3. Raman spectroscopy in pharmaceutical product design

    DEFF Research Database (Denmark)

    Paudel, Amrit; Raijada, Dhara; Rantanen, Jukka

    2015-01-01

    molecular-based drug discovery, design of innovative drug delivery systems and quality control of finished products. This review presents concise accounts of various conventional and emerging Raman instrumentations including associated hyphenated tools of pharmaceutical interest. Moreover, relevant...... application cases of Raman spectroscopy in early and late phase pharmaceutical development, process analysis and micro-structural analysis of drug delivery systems are introduced. Finally, potential areas of future advancement and application of Raman spectroscopic techniques are discussed....

  4. A product design framework for a circular economy

    NARCIS (Netherlands)

    Van den Berg, M.R.; Bakker, C.A.

    2015-01-01

    The paper provides a circular economy framework from a product design perspective with tools to aid product designers in applying circular product design in practice. Design research for circular economy has so far mainly been limited to referring to existing fields of research such as design for di

  5. Transitions in Sustainable Product Design Research

    DEFF Research Database (Denmark)

    Boks, Casper; McAloone, Tim C.

    2009-01-01

    By the early 1990s, sustainable product innovation (or ecodesign, or Design for environment) had gained sufficient critical mass in academic research to be identified as a distinct research area. In the past 15 years, stimulated by a growing environmental concern and awareness in the media......, this research area has expanded considerably; from a bunch of opportunistic eco-pathfinders trying to make products better recyclable into acknowledged scientific research regarding technology transfer and commercialisation. This paper proposes that this maturing process took place through a number...... of transitions; this is illustrated by discussing characteristic aspects of each transition, which together provide a historic account of how academic research into sustainable product innovation had matured. In conclusion, a number of possible future transitions or extensions of the research area are discussed....

  6. Decision models in designing flexible production systems

    Directory of Open Access Journals (Sweden)

    Florescu Adriana

    2017-01-01

    Full Text Available Flexible production system is a complex whole that raise some issues in terms of its design and in relation to the conditions for implementing it. To implement a flexible production system configuration must be found that satisfies both economic and system performance requirements. The configuration which best meet the objectives of introducing a flexible production system must be sought in the set of alternatives defined and evaluated. In this paper we present a methodology of realising the configuration and complex evaluation of the analyzed system. It will be developed models which generate new alternative configurations, optimization and evaluation models of the performance of the flexible production system. This will create a framework for interactive decision support, user-oriented that can be used by management to solve this selection problem. The applicative character of the study consist in tracking of the technological process in real time using the developed software package on the designed system, based on mathematical models for configuration and optimization of the system.

  7. Defining Patient Centric Pharmaceutical Drug Product Design.

    Science.gov (United States)

    Stegemann, Sven; Ternik, Robert L; Onder, Graziano; Khan, Mansoor A; van Riet-Nales, Diana A

    2016-09-01

    The term "patient centered," "patient centric," or "patient centricity" is increasingly used in the scientific literature in a wide variety of contexts. Generally, patient centric medicines are recognized as an essential contributor to healthy aging and the overall patient's quality of life and life expectancy. Besides the selection of the appropriate type of drug substance and strength for a particular indication in a particular patient, due attention must be paid that the pharmaceutical drug product design is also adequately addressing the particular patient's needs, i.e., assuring adequate patient adherence and the anticipate drug safety and effectiveness. Relevant pharmaceutical design aspects may e.g., involve the selection of the route of administration, the tablet size and shape, the ease of opening the package, the ability to read the user instruction, or the ability to follow the recommended (in-use) storage conditions. Currently, a harmonized definition on patient centric drug development/design has not yet been established. To stimulate scientific research and discussions and the consistent interpretation of test results, it is essential that such a definition is established. We have developed a first draft definition through various rounds of discussions within an interdisciplinary AAPS focus group of experts. This publication summarizes the outcomes and is intended to stimulate further discussions with all stakeholders towards a common definition of patient centric pharmaceutical drug product design that is useable across all disciplines involved.

  8. Behavior and Design Intent Based Product Modeling

    Directory of Open Access Journals (Sweden)

    László Horváth

    2004-11-01

    Full Text Available A knowledge based modeling of mechanical products is presented for industrial CAD/CAM systems. An active model is proposed that comprise knowledge from modeling procedures, generic part models and engineers. Present day models of mechanical systems do not contain data about the background of human decisions. This situation motivated the authors at their investigations on exchange design intent information between engineers. Their concept was extending of product models to be capable of description of design intent information. Several human-computer and human-human communication issues were considered. The complex communication problem has been divided into four sub-problems, namely communication of human intent source with the computer system, representation of human intent, exchange of intent data between modeling procedures and communication of the represented intent with humans. Paper discusses the scenario of intelligent modeling based engineering. Then key concepts for the application of computational intelligence in computer model based engineering systems are detailed including knowledge driven models as well as areas of their application. Next, behavior based models with intelligent content involving specifications and knowledge for the design processes are emphasized and an active part modeling is proposed and possibilities for its application are outlined. Finally, design intent supported intelligent modeling is discussed.

  9. Study on Design Methodology of Mass Customization Products

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Based on introduction characteristics and classific at ion of Mass Customization (MC), the paper expounds foundations and design me thods of MC. The foundations of MC production are standardization, seriation and normality of production, guiding thought of Concurrent Engineering (CE), ap plication of CAD/CAM technology and etc. And design methods of MC products are d esign for product family, modular design, parameterization CAD, variant design, design for manufacturing (DFM) and design by customers. ...

  10. Configuration Design of Product Service System for CNC Machine Tools

    OpenAIRE

    Zhongqi Sheng; Tao Xu; Junyou Song

    2015-01-01

    Product service system is a combination of product and services to meet the customer requirements. Configuration design is the key process of product service system development. This paper studies the configuration design of product service system for CNC machine tools. The research explores the configuration design process of product service system development, analyzes the retrieval method of product service system schemes, determines the configuration sequence of product modules and servic...

  11. Incorporating ISO Metadata Using HDF Product Designer

    Science.gov (United States)

    Jelenak, Aleksandar; Kozimor, John; Habermann, Ted

    2016-01-01

    The need to store in HDF5 files increasing amounts of metadata of various complexity is greatly overcoming the capabilities of the Earth science metadata conventions currently in use. Data producers until now did not have much choice but to come up with ad hoc solutions to this challenge. Such solutions, in turn, pose a wide range of issues for data managers, distributors, and, ultimately, data users. The HDF Group is experimenting on a novel approach of using ISO 19115 metadata objects as a catch-all container for all the metadata that cannot be fitted into the current Earth science data conventions. This presentation will showcase how the HDF Product Designer software can be utilized to help data producers include various ISO metadata objects in their products.

  12. Recent advances in amino acid production by microbial cells.

    Science.gov (United States)

    Hirasawa, Takashi; Shimizu, Hiroshi

    2016-12-01

    Amino acids have been utilized for the production of foods, animal feeds and pharmaceuticals. After the discovery of the glutamic acid-producing bacterium Corynebacterium glutamicum by Japanese researchers, the production of amino acids, which are primary metabolites, has been achieved using various microbial cells as hosts. Recently, metabolic engineering studies on the rational design of amino acid-producing microbial cells have been successfully conducted. Moreover, the technology of systems biology has been applied to metabolic engineering for the creation of amino acid-producing microbial cells. Currently, new technologies including synthetic biology, single-cell analysis, and evolutionary engineering have been utilized to create amino acid-producing microbial cells. In addition, useful compounds from amino acids have been produced by microbial cells. Here, current researches into the metabolic engineering of microbial cells toward production of amino acids and amino acid-related compounds are reviewed.

  13. Eukaryotic protein production in designed storage organelles

    Directory of Open Access Journals (Sweden)

    Saloheimo Markku

    2009-01-01

    Full Text Available Abstract Background Protein bodies (PBs are natural endoplasmic reticulum (ER or vacuole plant-derived organelles that stably accumulate large amounts of storage proteins in seeds. The proline-rich N-terminal domain derived from the maize storage protein γ zein (Zera is sufficient to induce PBs in non-seed tissues of Arabidopsis and tobacco. This Zera property opens up new routes for high-level accumulation of recombinant proteins by fusion of Zera with proteins of interest. In this work we extend the advantageous properties of plant seed PBs to recombinant protein production in useful non-plant eukaryotic hosts including cultured fungal, mammalian and insect cells. Results Various Zera fusions with fluorescent and therapeutic proteins accumulate in induced PB-like organelles in all eukaryotic systems tested: tobacco leaves, Trichoderma reesei, several mammalian cultured cells and Sf9 insect cells. This accumulation in membranous organelles insulates both recombinant protein and host from undesirable activities of either. Recombinant protein encapsulation in these PBs facilitates stable accumulation of proteins in a protected sub-cellular compartment which results in an enhancement of protein production without affecting the viability and development of stably transformed hosts. The induced PBs also retain the high-density properties of native seed PBs which facilitate the recovery and purification of the recombinant proteins they contain. Conclusion The Zera sequence provides an efficient and universal means to produce recombinant proteins by accumulation in ER-derived organelles. The remarkable cross-kingdom conservation of PB formation and their biophysical properties should have broad application in the manufacture of non-secreted recombinant proteins and suggests the existence of universal ER pathways for protein insulation.

  14. AUTOMATIC APPROACH TO PRODUCT CONCEPTUAL DESIGN BASED ON CONSTRAINT NETWORK

    Institute of Scientific and Technical Information of China (English)

    Li Hongjie; Xiao Renbin

    2004-01-01

    Product design is considered as the constraint satisfaction problem (CSP), and a new design approach basedon constraint network is proposed and applied to make design automatic partially. By means of constraint extraction, constraint network construction and operation, constraint chains are acquired, and then the conceptual design scheme can be got by decoding the information stored in the design constraint chains, which provides a novelty method for mechanical product design automation. Shearing mechanism of shearing machine has been designed by this way.

  15. Embedded systems engineering for products and services design.

    Science.gov (United States)

    Ahram, Tareq Z; Karwowski, Waldemar; Soares, Marcelo M

    2012-01-01

    Systems engineering (SE) professionals strive to develop new techniques to enhance the value of contributions to multidisciplinary smart product design teams. Products and services designers challenge themselves to search beyond the traditional design concept of addressing the physical, social, and cognitive factors. This paper covers the application of embedded user-centered systems engineering design practices into work processes based on the ISO 13407 framework [20] to support smart systems and services design and development. As practitioners collaborate to investigate alternative smart product designs, they concentrate on creating valuable products which will enhance positive interaction. This paper capitalizes on the need to follow a user-centered SE approach to smart products design [4, 22]. Products and systems intelligence should embrace a positive approach to user-centered design while improving our understanding of usable value-adding, experience and extending our knowledge of what inspires others to design enjoyable services and products.

  16. Product design for elderly-visual design information inspired a new perspective in design education

    NARCIS (Netherlands)

    Langeveld, L.H.

    2014-01-01

    A workshop Product Design for Elderly was held in Beijing and organized by the School of Digital Media and Design, Beijing University of Posts and Telecommunications. A domestic appliances company had sponsored a part of the workshop and brought in the topics. The objectives of the workshop were cre

  17. The Current of Continuing Professional Development for Product Designers

    OpenAIRE

    山内, 勉; Yamauchi, Tsutomu

    2010-01-01

    Product Designers are required some skills and knowledge in the product development. Based on my professional career, I presumed three skills, they are, Technical skills, Conceptual skills and Human skills. In this study, I interviewed some Product Designers to make sure what skills are needed in the product development process. It emerged that Product Designers are expected to improve their Conceptual and Human skills besides Technical skills for playing a part at the upper and lower stage o...

  18. 36 CFR 1193.23 - Product design, development, and evaluation.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Product design, development... § 1193.23 Product design, development, and evaluation. (a) Manufacturers shall evaluate the accessibility... incorporate such evaluation throughout product design, development, and fabrication, as early and...

  19. 47 CFR 7.7 - Product design, development, and evaluation.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Product design, development, and evaluation. 7...? § 7.7 Product design, development, and evaluation. (a) Manufacturers and service providers shall... shall incorporate such evaluation throughout product design, development, and fabrication, as early...

  20. 47 CFR 6.7 - Product design, development, and evaluation.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Product design, development, and evaluation. 6... Obligations-What Must Covered Entities Do? § 6.7 Product design, development, and evaluation. (a... identify barriers to accessibility and usability as part of such a product design and development...

  1. Design, production and materials of PV-powered consumer products - The case of mass production

    NARCIS (Netherlands)

    Reinders, A.H.M.E.; Akkerman, R.

    2005-01-01

    Though many options exist, the application of integrated PV systems in mass produced consumer products is still unusual and rare [1]. Therefore, to date, design and manufacturing aspects of product-integrated PV systems have been explored only to a very limited extent. The requirements for the desig

  2. New Vistas in Chemical Product and Process Design

    DEFF Research Database (Denmark)

    Zhang, Lei; Babi, Deenesh Kavi; Gani, Rafiqul

    2016-01-01

    Design of chemicals-based products is broadly classified into those that are process centered and those that are product centered. In this article, the designs of both classes of products are reviewed from a process systems point of view; developments related to the design of the chemical product......, its corresponding process, and its integration are highlighted. Although significant advances have been made in the development of systematic model-based techniques for process design (also for optimization, operation, and control), much work is needed to reach the same level for product design....... Timeline diagrams illustrating key contributions in product design, process design, and integrated product-process design are presented. The search for novel, innovative, and sustainable solutions must be matched by consideration of issues related to the multidisciplinary nature of problems, the lack...

  3. Product design pattern based on big data-driven scenario

    Directory of Open Access Journals (Sweden)

    Conggang Yu

    2016-07-01

    Full Text Available This article discusses about new product design patterns in the big data era, gives designer a new rational thinking way, and is a new way to understand the design of the product. Based on the key criteria of the product design process, category, element, and product are used to input the data, which comprises concrete data and abstract data as an enlargement of the criteria of product design process for the establishment of a big data-driven product design pattern’s model. Moreover, an experiment and a product design case are conducted to verify the feasibility of the new pattern. Ultimately, we will conclude that the data-driven product design has two patterns: one is the concrete data supporting the product design, namely “product–data–product” pattern, and the second is based on the value of the abstract data for product design, namely “data–product–data” pattern. Through the data, users are involving themselves in the design development process. Data and product form a huge network, and data plays a role of connection or node. So the essence of the design is to find a new connection based on element, and to find a new node based on category.

  4. Product Design – From Molecules to Formulations to Devices

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Ng, Ka M.

    2014-01-01

    Product design is a multidisciplinary and diverse subject. This article focuses on product conceptualization (what-to-make) and briefly reviews the corresponding manufacturing processes (how-to-make). Four product types are considered – molecular products, formulated products, devices...... and functional products. For molecular products, computer-aided design tools are used to predict the physicochemical properties of single molecules and blends. For formulated products, an integrated experiment-molecular modelling approach to generate the formula with the specified product attributes is followed....... For devices and functional products, conceptual product design is carried out by modelling the product based on thermodynamics, kinetics and transport processes, by performing experiments, and by decision making based on experience. The results are product specifications in terms of the type of ingredients...

  5. Improved vanillin production in baker's yeast through in silico design

    Directory of Open Access Journals (Sweden)

    Hansen Jørgen

    2010-11-01

    Full Text Available Abstract Background Vanillin is one of the most widely used flavouring agents, originally obtained from cured seed pods of the vanilla orchid Vanilla planifolia. Currently vanillin is mostly produced via chemical synthesis. A de novo synthetic pathway for heterologous vanillin production from glucose has recently been implemented in baker's yeast, Saccharamyces cerevisiae. In this study we aimed at engineering this vanillin cell factory towards improved productivity and thereby at developing an attractive alternative to chemical synthesis. Results Expression of a glycosyltransferase from Arabidopsis thaliana in the vanillin producing S. cerevisiae strain served to decrease product toxicity. An in silico metabolic engineering strategy of this vanillin glucoside producing strain was designed using a set of stoichiometric modelling tools applied to the yeast genome-scale metabolic network. Two targets (PDC1 and GDH1 were selected for experimental verification resulting in four engineered strains. Three of the mutants showed up to 1.5 fold higher vanillin β-D-glucoside yield in batch mode, while continuous culture of the Δpdc1 mutant showed a 2-fold productivity improvement. This mutant presented a 5-fold improvement in free vanillin production compared to the previous work on de novo vanillin biosynthesis in baker's yeast. Conclusion Use of constraints corresponding to different physiological states was found to greatly influence the target predictions given minimization of metabolic adjustment (MOMA as biological objective function. In vivo verification of the targets, selected based on their predicted metabolic adjustment, successfully led to overproducing strains. Overall, we propose and demonstrate a framework for in silico design and target selection for improving microbial cell factories.

  6. Photovoltaic cell and production thereof

    Science.gov (United States)

    Narayanan, Srinivasamohan; Kumar, Bikash

    2008-07-22

    An efficient photovoltaic cell, and its process of manufacture, is disclosed wherein the back surface p-n junction is removed from a doped substrate having an oppositely doped emitter layer. A front surface and edges and optionally the back surface periphery are masked and a back surface etch is performed. The mask is not removed and acts as an anti-reflective coating, a passivating agent, or both. The photovoltaic cell retains an untextured back surface whether or not the front is textured and the dopant layer on the back surface is removed to enhance the cell efficiency. Optionally, a back surface field is formed.

  7. Expression regulation of design process gene in product design

    DEFF Research Database (Denmark)

    Fang, Lusheng; Li, Bo; Tong, Shurong

    2011-01-01

    is proposed and analyzed, as well as its three categories i.e., the operator gene, the structural gene and the regulator gene. Second, the trigger mechanism that design objectives and constraints trigger the operator gene is constructed. Third, the expression principle of structural gene is analyzed......To improve the design process efficiency, this paper proposes the principle and methodology that design process gene controls the characteristics of design process under the framework of design process reuse and optimization based on design process gene. First, the concept of design process gene...... with the example of design management gene. Last, the regulation mode that the regulator gene regulates the expression of the structural gene is established and it is illustrated by taking the design process management gene as an example. © (2011) Trans Tech Publications....

  8. DESIGN ATTRIBUTES OPTIMIZATION MODEL FOR CUSTOMIZED PRODUCT AND ITS APPLICATION

    Institute of Scientific and Technical Information of China (English)

    Cao Le; Liu Fei; Lei Qi

    2005-01-01

    By formulating the design of customized product as a multi-objective optimization problem,a method for designing customized product according to the relative importance of customer needs is proposed. This method searches for the optimal design that maximizes customer satisfaction by establishing mapping from design attributes to the degree of customer satisfaction on each customer need.A window product is taken as an example for case study. The result indicates that this method is feasible.

  9. Product quality driven food process design

    NARCIS (Netherlands)

    Hadiyanto, M.

    2007-01-01

    Consumers evaluate food products on their quality, and thus the product quality is a main target in industrial food production. In the last decade there has been a remarkable increase of interest of the food industry to put food product quality central in innovation. However, quality itself is seldo

  10. Audio-visual interactions in product sound design

    Science.gov (United States)

    Özcan, Elif; van Egmond, René

    2010-02-01

    Consistent product experience requires congruity between product properties such as visual appearance and sound. Therefore, for designing appropriate product sounds by manipulating their spectral-temporal structure, product sounds should preferably not be considered in isolation but as an integral part of the main product concept. Because visual aspects of a product are considered to dominate the communication of the desired product concept, sound is usually expected to fit the visual character of a product. We argue that this can be accomplished successfully only on basis of a thorough understanding of the impact of audio-visual interactions on product sounds. Two experimental studies are reviewed to show audio-visual interactions on both perceptual and cognitive levels influencing the way people encode, recall, and attribute meaning to product sounds. Implications for sound design are discussed defying the natural tendency of product designers to analyze the "sound problem" in isolation from the other product properties.

  11. Building quality into medical product software design.

    Science.gov (United States)

    Mallory, S R

    1993-01-01

    The software engineering and quality assurance disciplines are a requisite to the design of safe and effective software-based medical devices. It is in the areas of software methodology and process that the most beneficial application of these disciplines to software development can be made. Software is a product of complex operations and methodologies and is not amenable to the traditional electromechanical quality assurance processes. Software quality must be built in by the developers, with the software verification and validation engineers acting as the independent instruments for ensuring compliance with performance objectives and with development and maintenance standards. The implementation of a software quality assurance program is a complex process involving management support, organizational changes, and new skill sets, but the benefits are profound. Its rewards provide safe, reliable, cost-effective, maintainable, and manageable software, which may significantly speed the regulatory review process and therefore potentially shorten the overall time to market. The use of a trial project can greatly facilitate the learning process associated with the first-time application of a software quality assurance program.

  12. DATA CRYSTALLIZATION APPLIED FOR DESIGNING NEW PRODUCTS

    Institute of Scientific and Technical Information of China (English)

    Kenichi HORIE; Yoshiharu MAENO; Yukio OHSAWA

    2007-01-01

    It is only the observable part of the real world that can be stored in data.For such incomplete and ill-structured data,data crystallizing aims at presenting the hidden structure among events including unobservable events.This is realized by data crystallization,where dummy items,corresponding to potential existence ofunobservable events,are inserted to the given data.These dummy items and their relations with observable events are visualized by applying KeyGraph to the data with dummy items,like the crystallization of snow where dusts are involved in the formation of crystallization of water molecules.For tuning the granularity level of structure to be visualized,the tool of data crystallization is integrated with human's process of understanding significant scenarios in the real world.This basic method is expected to be applicable for various real world domains where previous methods of chance-discovery lead human to successful decision making.In this paper,we apply the data crystallization with human-interactive annealing (DCHA) to the design of products in a real company.The results show its effect to industrial decision making.

  13. A Contradiction-Based Approach for Innovative Product Design

    Directory of Open Access Journals (Sweden)

    Ko Yao-Tsung

    2016-01-01

    Full Text Available Without creativity in design there is no potential for innovation. This paper investigates the role of contradictions in enhancing creativity in product design. Based on the inventive principles of TRIZ, this paper presents a novel design method by integrating technical and physical contradiction analysis methods into the conceptual design activities of new product development (NPD. Despite the recognized importance of innovative design, there is a lack of the systematic and effective design-thinking process that can covers all conceptual design activities. To address this gap, a sharper and fundamental model of the problem-solving is created for innovative product design based on the contradiction-oriented concept. Eventually, one case study is employed to illustrate the method and the result validates that it can help designers produce more creative outcomes in product design.

  14. Research and Development of Growth Design System for Mechanical Products

    Institute of Scientific and Technical Information of China (English)

    YANG Bo; ZE Xiangbo; YANG Tao; CUI Weihua; LIU Luning

    2006-01-01

    By applying genetic engineering methodology into the incremental product growth design, a generic structural design approach is put forward, as well as an intelligent evolution strategy of the product units growth, which is based on the multilevel Decomposition and Reconstruction of product gene. To guarantee a successful transformation from functional requirement to geometry constraints between parts in the incremental growth design of mechanical product, the integrated design method incorporates the design requirements and assembly perspective into product genetic information. The mathematical model of state transition during incremental design process are given at first, based on which product can grow step by step from functional requirement to the final geometrical product structure automatically. And then, to quantify the measurement of assembly efficiency, a mathematical model as well as a technology to quantify assembly constraints was developed by application of some fuzzy logic algorithms. Finally, examples have been proved that the approach is promising.

  15. Cork Design: A Design Action Intervention Approach Towards Sustainable Product Innovation

    NARCIS (Netherlands)

    Mestre, A.C.C.M.

    2014-01-01

    The study Cork Design: A Design Action Intervention Approach Towards Sustainable Product Innovation comprises the systematic implementation of sustainable product innovation within the Portuguese cork sector, through action research. Cork is a natural, recyclable, non-toxic, and renewable resource,

  16. Fuel cells principles, design, and analysis

    CERN Document Server

    Revankar, Shripad T

    2014-01-01

    ""This book covers all essential themes of fuel cells ranging from fundamentals to applications. It includes key advanced topics important for understanding correctly the underlying multi-science phenomena of fuel cell processes. The book does not only cope with traditional fuel cells but also discusses the future concepts of fuel cells. The book is rich on examples and solutions important for applying the theory into practical use.""-Peter Lund, Aalto University, Helsinki""A good introduction to the range of disciplines needed to design, build and test fuel cells.""-Nigel Brandon, Imperial Co

  17. Designing in an Interplay with a Product Model - Explained by Design Units

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Andreasen, Mogens Myrup

    1996-01-01

    If we expand the concept of product models from a bill of material and representations of parts to a genetic model (a chromosome), which is able to capture decisions on functions and design concepts during the design activity, a new design situation is created. This paper treats designing...... in an interplay with a product model in a so-called Designer's Workbench, based on the clarification of the structuring of the product model, the design operationswhich succesively build up the product model, and the role of the product model in the design work as basis for synthesis and modelling of properties....... The main results from this paper are identification of the classes of product models in a Designer's Workbench and description of a scenario for designing in an interplay with the product models....

  18. Plant Design for the Production of DUAGG

    Energy Technology Data Exchange (ETDEWEB)

    Ferrada, J.J.

    2003-02-04

    The cost of producing DUAGG is an important consideration for any interested private firm in determining whether DUCRETE is economically viable as a material of construction in next-generation spent nuclear fuel casks. This study analyzed this project as if it was a stand-alone project. The capital cost includes engineering design, equipment costs and installation, start up, and management; the study is not intended to be a life-cycle cost analysis. The costs estimated by this study are shown in Table ES.1, and the conclusions of this study are listed in Table ES.2. The development of DUAGG and DUCRETE is a major thrust of the Depleted Uranium Uses Research and Development Project. An obvious use of depleted uranium is as a shielding material (e.g., DUCRETE). DUCRETE is made by replacing the conventional stone aggregate in concrete with DUAGG. One objective of this project is to bring the development of DUCRETE to a point at which a demonstrated basis exists for its commercial deployment. The estimation of the costs to manufacture DUAGG is an important part of this effort. Paul Lessing and William Quapp developed DUAGG and DUCRETE as part of an Idaho National Engineering and Environmental Laboratory (INEEL) program to find beneficial uses for depleted uranium (DU). Subsequently, this technology was licensed to Teton Technologies, Inc. The DUAGG process mixes DUO{sub 2} with sintering materials and additives to form pressed briquettes. These briquettes are sintered at 1300 C, and the very dense sintered briquettes are then crushed and classified into gap-graded size fractions. The graded DUAGG is then ready to be used to make high-strength heavy DUCRETE. The DUCRETE shielding will be placed into an annular steel cask-shell mold, which has internal steel reinforcing bars. The objectives of this study are to (1) use previous DUAGG process developments to design a plant that will produce DUAGG at a baseline rate, (2) determine the size of the equipment required to meet

  19. Engineered CHO cells for production of diverse, homogeneous glycoproteins

    DEFF Research Database (Denmark)

    Yang, Zhang; Wang, Shengjun; Halim, Adnan;

    2015-01-01

    genes controlling N-glycosylation in CHO cells and constructed a design matrix that facilitates the generation of desired glycosylation, such as human-like alpha 2,6-linked sialic acid capping. This engineering approach will aid the production of glycoproteins with improved properties and therapeutic...

  20. Nature-Inspired Design: Strategies for Sustainable Product Development

    NARCIS (Netherlands)

    De Pauw, I.C.

    2015-01-01

    Product designers can apply different strategies, methods, and tools for sustainable product development. Nature-Inspired Design Strategies (NIDS) offer designers a distinct class of strategies that use ‘nature’ as a guiding source of knowledge and inspiration for addressing sustainability. Biomimic

  1. Teaching User-Centered Design in New Product Marketing

    Science.gov (United States)

    Love, Edwin; Stone, Donn E.; Wilton, Taine

    2011-01-01

    Thanks in part to groundbreaking work by companies such as Apple and IDEO, there has been growing interest in design as a way to improve the odds of new product success. This paper describes a user-centered design workshop developed for a new product marketing course. The workshop included exercises designed to explain and illustrate the…

  2. Product integrated PV: the future is design and styling

    NARCIS (Netherlands)

    Eggink, Wouter; Reinders, Angèle

    2016-01-01

    In this paper we explore how PV powered products have been designed in the past. For this purpose we have drawn a historical time line of the design features of PV powered products in the context of main stream design and styling. Our time frame is 1970 till 2016, focusing in first instance on consu

  3. Designing Integrated Product- Service System Solutions in Manufacturing Industries

    DEFF Research Database (Denmark)

    Costa, Nina; Patrício, Lia; Morelli, Nicola

    2015-01-01

    Manufacturing firms are increasingly evolving towards the design of integrated product-service solutions but servitization literature does not provide specific guidance on how to design these integrated solutions. Building upon ProductService System (PSS) and Service Design (SD) approaches...... how it brings new insights to manufacturing companies moving to a service, value cocreation perspective....

  4. Study of Mechanical Product Rapid Design Based on Knowledge Engineering

    Institute of Scientific and Technical Information of China (English)

    TAI Li-gang; ZHONG Ting-xiu

    2005-01-01

    This paper proposes a mechanical product intelligent rapid design approach based on integrated technologies. Adopting knowledge based engineering to reuse and manage product design knowledge, and combining feature modeling and parametric design based on existing CAD/CAE/CAM system and technology of product family modeling and engineering database, the system establishes a product family knowledge base, which mainly including product family case base and rule base. The system also utilizes WEB technology to let customers to individually customize products remotely through internet. And an applicable example is given in the end.

  5. Mammalian designer cells: Engineering principles and biomedical applications.

    Science.gov (United States)

    Xie, Mingqi; Fussenegger, Martin

    2015-07-01

    Biotechnology is a widely interdisciplinary field focusing on the use of living cells or organisms to solve established problems in medicine, food production and agriculture. Synthetic biology, the science of engineering complex biological systems that do not exist in nature, continues to provide the biotechnology industry with tools, technologies and intellectual property leading to improved cellular performance. One key aspect of synthetic biology is the engineering of deliberately reprogrammed designer cells whose behavior can be controlled over time and space. This review discusses the most commonly used techniques to engineer mammalian designer cells; while control elements acting on the transcriptional and translational levels of target gene expression determine the kinetic and dynamic profiles, coupling them to a variety of extracellular stimuli permits their remote control with user-defined trigger signals. Designer mammalian cells with novel or improved biological functions not only directly improve the production efficiency during biopharmaceutical manufacturing but also open the door for cell-based treatment strategies in molecular and translational medicine. In the future, the rational combination of multiple sets of designer cells could permit the construction and regulation of higher-order systems with increased complexity, thereby enabling the molecular reprogramming of tissues, organisms or even populations with highest precision.

  6. Flow cell design for effective biosensing

    OpenAIRE

    Pike, DJ; Kapur, N; Millner, PA; Stewart, DI

    2012-01-01

    The efficiency of three different biosensor flow cells is reported. All three flow cells featured a central channel that expands in the vicinity of the sensing element to provide the same diameter active region, but the rate of channel expansion and contraction varied between the designs. For each cell the rate at which the analyte concentration in the sensor chamber responds to a change in the influent analyte concentration was determined numerically using a finite element model and experime...

  7. Concave cell design for FTIR measurements

    Institute of Scientific and Technical Information of China (English)

    Xiang Qin Lin; Zhi Xiang Zhang; Wan Qun Hu

    2011-01-01

    Wedged and V-shaped cells have advantages on depressing strong absorption bands and keeping the photo windows wide open without absorption block. Alternatively, this work presents a concave cell design, which is constructed by a plano-convex CaF2 lens in combination with a flat plate. Mathematical equations have been provided for data treatment with Matlab programs. The result indicates that the concave cell has advantages similar to the V-shaped cell. Reflection-absorption measurements of ethanol have been conducted on the cell in mid-IR region for demonstration. The spectrum obtained from the concave cell can easily be interpreted to regenerate its normal spectrum, which is fitting well with the spectrum taken in a conventional thin-layer cell. The concave cell is easier to construct and more convenient to operate, willing to have popular usages.

  8. A Knowledge Based Interactive System for Complex Product Design

    Science.gov (United States)

    Gayretli, Ahmet

    This research presents a new Artificial Intelligence (AI) based product development approach for integrating mechanical design with electronic design to improve design and manufacture of electromechanical products by avoiding design conflicts in the early stages of the design process. The proposed approach has been implemented in a Delphi based environment integrated with a CAD system. The system assists designers from different disciplines in evaluating complex systems as far as parts relation, potential effects on each other, conflict management, costs, weight and physical constraints are concerned in the early design stages. This helps the designers to avoid design iterations leading to longer lead-time, hence increased cost. The developed system enables to rapidly develop and evaluate new complex products and add new functions to the existing products within given constraints.

  9. High-Volume Production of Lightweight Multijunction Solar Cells

    Science.gov (United States)

    Youtsey, Christopher

    2015-01-01

    MicroLink Devices, Inc., has transitioned its 6-inch epitaxial lift-off (ELO) solar cell fabrication process into a manufacturing platform capable of sustaining large-volume production. This Phase II project improves the ELO process by reducing cycle time and increasing the yield of large-area devices. In addition, all critical device fabrication processes have transitioned to 6-inch production tool sets designed for volume production. An emphasis on automated cassette-to-cassette and batch processes minimizes operator dependence and cell performance variability. MicroLink Devices established a pilot production line capable of at least 1,500 6-inch wafers per month at greater than 80 percent yield. The company also increased the yield and manufacturability of the 6-inch reclaim process, which is crucial to reducing the cost of the cells.

  10. Simulation-based comparisons of four apparel cell production modes of one clothing production line

    Directory of Open Access Journals (Sweden)

    Guoqiang Pan

    2014-10-01

    Full Text Available Purpose: This research, by using the SIMIO simulation platform, provides a quantitative and comparative analysis of how the efficiency of four different cell production modes is affected. It is hoped that the outcomes will be of some help for garment factories to optimize their production lines. Design/methodology/approach: The SIMIO simulation platform was employed in the research and comparisons were made of the simulation test results about the four different production modes. Findings: The operation mode, number of operators, and number of buffer areas are key factors affecting the production line efficiency, and need to be reasonably set to achieve the highest efficiency. Originality/value: As most research literature so far is qualitative, this research provided a simulation-based quantitative analysis of the production efficiency under different cell production modes.

  11. The Multimedia Product - between Design and Information, Design and Utility and Design and Entertainment

    Directory of Open Access Journals (Sweden)

    Dieter Penteliuc-Cotosman

    2006-01-01

    Full Text Available The paper investigates the possible coherent and effective alternatives to solve the problems related to the communication needs of any multimedia product. In essence, the presentation will focus on identifying the issues and principles governing three types of the design - in fact, the multimedia design in a broader sense - namely the information design – precisely aiming at ways of organization and presentation of information in a useful and significant form, the graphical user interface design, whose sub-domain consists of the information displayed on the monitor screen and of interactivity between user, computer and electronic devices, meaning, in fact, everything the user sees, touches, hears and all the elements with which he interacts, the graphic design, whose main concern is to create an aesthetic layout arrangement ( from the visual and perceptive information.

  12. Regulatory considerations in production of a cell therapy medicinal product in Europe to clinical research.

    Science.gov (United States)

    Martín, Patricia Gálvez; Martinez, Adolfina Ruiz; Lara, Visitación Gallardo; Naveros, Beatriz Clares

    2014-02-01

    The development of new drugs using stem cells has become a clinic alternative for the treatment of different diseases such as Alzheimer's, diabetes and myocardial infarction. Similar to conventional medicines, stem cells as new medicinal products for cell therapy are subjected to current legislation concerning their manufacture process. Besides, their legality is determined by the Regulatory Agencies belonging to the Member State of the European Union in which they are being registered. With the evolution of therapy that uses cells as medicines, there is a need to develop the appropriate legislative and regulatory framework capable of ensuring their safety and effectiveness. However, few works have been published regarding the regulations that these products must comply through production and commercialization processes. The present work is focused on the description of key events during clinical development and cell production of stem cells as drugs. Such as the regulations, requirements and directives involved in the production of cell therapy medicinal products, from the clinical design stage to its commercialization in Europe.

  13. Developing engineering design core competences through analysis of industrial products

    DEFF Research Database (Denmark)

    Hansen, Claus Thorp; Lenau, Torben Anker

    2011-01-01

    Most product development work carried out in industrial practice is characterised by being incremental, i.e. the industrial company has had a product in production and on the market for some time, and now time has come to design a new and upgraded variant. This type of redesign project requires...... a product analysis method and a staging of it, which seems to be very productive. Product Analysis and Redesign is a first year course module of the bachelor education Design & Innovation at the Technical University of Denmark. In this paper we will present our product analysis method and we will reflect...

  14. Marketing and Product Design: A Rocky Love Affair

    Directory of Open Access Journals (Sweden)

    Landwehr Jan R.

    2015-11-01

    Full Text Available The success stories of design-oriented companies like Apple, Audi or Nike have put design on the agenda in many marketing departments. Consumers cannot elude the effect of aesthetics and therefore design is a major factor for business success. Typically consumers choose the product with the best design, all other aspects being equal. Only when the interplay of product characteristics, brand and design is carefully coordinated can successful products be created. This requires an integrated approach to design, one which is applied right at the beginning of the value chain. Product development, marketing and design need to work in close cooperation, communicate well and frequently, and collect feedback from the market. Superior aesthetics are always important but should be a top priority in cases where efficiency-oriented Asian competitors are able to offer functionally similar products at much lower prices.

  15. Cell culture processes for monoclonal antibody production

    OpenAIRE

    LI Feng; Vijayasankaran, Natarajan; Shen, Amy (Yijuan); Kiss, Robert; Amanullah, Ashraf

    2010-01-01

    Animal cell culture technology has advanced significantly over the last few decades and is now generally considered a reliable, robust and relatively mature technology. A range of biotherapeutics are currently synthesized using cell culture methods in large scale manufacturing facilities that produce products for both commercial use and clinical studies. The robust implementation of this technology requires optimization of a number of variables, including (1) cell lines capable of synthesizin...

  16. Fungal protein production: Design and production of chimeric proteins

    NARCIS (Netherlands)

    Punt, P.J.; Levasseur, A.; Visser, H.; Wery, J.; Record, E.

    2011-01-01

    For more than a century, filamentous fungi have been used for the production of a wide variety of endogenous enzymes of industrial interest. More recently, with the use of genetic engineering tools developed for these organisms, this use has expanded for the production of nonnative heterologous prot

  17. PROPOSAL OF SPATIAL OPTIMIZATION OF PRODUCTION PROCESS IN PROCESS DESIGNER

    Directory of Open Access Journals (Sweden)

    Peter Malega

    2015-03-01

    Full Text Available This contribution is focused on optimizing the use of space in the production process using software Process Designer. The aim of this contribution is to suggest possible improvements to the existing layout of the selected production process. Production process was analysed in terms of inputs, outputs and course of actions. Nowadays there are many software solutions aimed at optimizing the use of space. One of these software products is the Process Designer, which belongs to the product line Tecnomatix. This software is primarily aimed at production planning. With Process Designer is possible to design the layout of production and subsequently to analyse the production or to change according to the current needs of the company.

  18. Audio-visual interactions in product sound design

    NARCIS (Netherlands)

    Özcan, E.; Van Egmond, R.

    2010-01-01

    Consistent product experience requires congruity between product properties such as visual appearance and sound. Therefore, for designing appropriate product sounds by manipulating their spectral-temporal structure, product sounds should preferably not be considered in isolation but as an integral p

  19. 77 FR 72653 - Designation of Product Categories for Federal Procurement

    Science.gov (United States)

    2012-12-05

    ... propose new product categories for designation for Federal preferred procurement. USDA has developed a...- qualifying products and do not offer biobased alternatives may experience a decrease in demand from Federal... products identified during the development of this Federal Register notice for these product...

  20. In silico product design of pharmaceuticals

    Directory of Open Access Journals (Sweden)

    Johan Boetker

    2016-08-01

    Full Text Available The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale toward infinity, their uniqueness requires a versatile production platform and numerical simulation in order to be manufactured efficiently. A mathematical description of these systems is the only feasible approach to manage such diverse properties of different products. However, experimental verification is still essential for evaluation of processability and related concomitant phenomena, such as possible solid state changes that may occur during production and storage.

  1. Applying axiomatic design methodology in developing modified libertation products

    Directory of Open Access Journals (Sweden)

    Bibiana Margarita Vallejo Díaz

    2010-04-01

    Full Text Available Some conceptual elements regarding the axiomatic design method were applied to a specific case-study regarding developing modified liberation compressed product (CLM-UN, for use in the agricultural sector as pH regulating agent in solil. The study was orientated towards defining functional requeriments, design parameters and process variables for manufacturing the product. Independence and information were evaluated, supporting axiomatic design as an alternative for integral product and process design (as a rational and systemic exercise, facilitating producing products having the quality which future users expect from them.

  2. Product Variant Master as a Means to Handle Variant Design

    DEFF Research Database (Denmark)

    Hildre, Hans Petter; Mortensen, Niels Henrik; Andreasen, Mogens Myrup

    1996-01-01

    The overall time requiered to design a new product variant relies on two factor: how good the methods to design the new variant are and how good these method are supported by computers.It has been estimated that 80% of all design tasks are variational in that the goal of the design is to adapt an...

  3. Plant cell culture strategies for the production of natural products.

    Science.gov (United States)

    Ochoa-Villarreal, Marisol; Howat, Susan; Hong, SunMi; Jang, Mi Ok; Jin, Young-Woo; Lee, Eun-Kyong; Loake, Gary J

    2016-03-01

    Plants have evolved a vast chemical cornucopia to support their sessile lifestyles. Man has exploited this natural resource since Neolithic times and currently plant-derived chemicals are exploited for a myriad of applications. However, plant sources of most high-value natural products (NPs) are not domesticated and therefore their production cannot be undertaken on an agricultural scale. Further, these plant species are often slow growing, their populations limiting, the concentration of the target molecule highly variable and routinely present at extremely low concentrations. Plant cell and organ culture constitutes a sustainable, controllable and environmentally friendly tool for the industrial production of plant NPs. Further, advances in cell line selection, biotransformation, product secretion, cell permeabilisation, extraction and scale-up, among others, are driving increases in plant NP yields. However, there remain significant obstacles to the commercial synthesis of high-value chemicals from these sources. The relatively recent isolation, culturing and characterisation of cambial meristematic cells (CMCs), provides an emerging platform to circumvent many of these potential difficulties. [BMB Reports 2016; 49(3): 149-158].

  4. Product Modelling and Functional Reasoning in Conceptual Design

    Institute of Scientific and Technical Information of China (English)

    林志航; 宋慧军; 陈康宁

    2004-01-01

    In this paper, a product model in conceptual design, Domain Structure Template, is proposed, which combines the functional domain and the physical domain with the behaviour domain. Seven types of primary mappings units connecting functions, behaviours and carriers during conceptual design process are identified according to the characteristics of the conceptual design of mechanical products.Based on these seven primary mappings, a hierarchical functional reasoning framework characterizing the process of conceptual design is presented. A case study for the conceptual design of industry sewing machines with chain-stitch is described to demonstrate the product modelling and the scheme generation based on the presented model.

  5. Product System Design – to Household Massage Design as An Example

    Directory of Open Access Journals (Sweden)

    Wang Huabin

    2016-01-01

    Full Text Available Explain what is the system design and the applications of System design in the product design process. Using The whole idea and systems design methods to analyze the design of household hand massage,Use a chart image to explain that Household hand massage products in the influence of user and the environment, the influence of large system environment for the product. The use of components of the system to anatomy product design. Each system components has a link between and mutual correlation.

  6. QFood - Optimal design of food products

    DEFF Research Database (Denmark)

    Bech, Anne C.; Engelund, Erling; Juhl, Hans Jørn

    1994-01-01

    of Quality is described with special reference to the development of food products. 5. An MDS-based model for use in the evaluation of an optimal product is developed. The model is based on the profit function from classical micro-economic theory. The imputed price is defined as a function of a Customer...

  7. In silico product design of pharmaceuticals

    DEFF Research Database (Denmark)

    Boetker, Johan; Raijada, Dhara; Aho, Johanna

    2016-01-01

    Abstract The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale towards infinity, their uniqueness require a versatile production platform and numerical simulation in order to be manufacture...

  8. On the logistics effects of integrated product and package design

    DEFF Research Database (Denmark)

    Bramklev, Caroline; Hansen, Claus Thorp

    2007-01-01

    of literature, which shows that there is a need for research into Integrated Product and Package Design. Secondly, we have analysed three cases from industrial practice, which show that a conscious and integrated design of product and package has positive logistics effects, whereas neglecting this issue might......If engineering designers consciously design product and package in an integrated manner, there is a great potential for industrial global enterprises to develop and product mechanical products, such as exhaust extraction systems, car washer machines and fuel handling systems while simultaneously...... obtaining error-free deliveries, saving costs and avoiding quality problems. Thus, the authors of this paper see a challenge in developing the theory and methodology for Integrated Product and Package Design. In this paper we take a first step in this direction. Firstly, we have carried out a broad review...

  9. PRINCIPLE OF POST-PRODUCTION DESIGN OF HYDRAULIC ACTUATORS

    Directory of Open Access Journals (Sweden)

    A. V. Puzanov

    2015-01-01

    Full Text Available In work the problem of design-technology preparation of production of hydraulic actuators is staticized. The structure and business processes of design and production are analysed. Methods and means of reorganization of project works for the purpose of cutting-down of time of preparation of production are offered. The directions of reorganization of process of design are formulated. The principle of carrying out procedures of design-technology preparation of production of hydraulic actuators with use of ready elements of a production cycle is considered. The scheme of their practical realization at machine-building enterprise is offered. The assessment of growth of efficiency of design-technology preparation of production is given in machine-building enterprise.

  10. Research on integrating customization design for mechanical product

    Institute of Scientific and Technical Information of China (English)

    TAI Ligang; LI Dianqi; ZHONG Tingxiu; LI Zhi

    2007-01-01

    This paper proposes an integrating rapid custom- ization design system which combines various technologies such as Web, knowledge based engineering (KBE), engineer- hag database and Computer Aided Design (CAD) and has been used in elevator design. The whole system is set up on the base of engineering database technology, integrating Product Data Management (PDM), Enterprise Resource Planning (ERP) etc. It adopts Web technology to enable cus- tomers to individually customize products remotely through the internet. The system also adopts KBE to manage and reuse product design knowledge, while combining the tech- nology of product family modeling and technologies of feature modeling and parametric design, based on the assem- bly of the CAD system of Unigraphics Solutions Inc., to create a product family case library that achieves intelligent, rapid design customization.

  11. Designer proton-channel transgenic algae for photobiological hydrogen production

    Science.gov (United States)

    Lee, James Weifu

    2011-04-26

    A designer proton-channel transgenic alga for photobiological hydrogen production that is specifically designed for production of molecular hydrogen (H.sub.2) through photosynthetic water splitting. The designer transgenic alga includes proton-conductive channels that are expressed to produce such uncoupler proteins in an amount sufficient to increase the algal H.sub.2 productivity. In one embodiment the designer proton-channel transgene is a nucleic acid construct (300) including a PCR forward primer (302), an externally inducible promoter (304), a transit targeting sequence (306), a designer proton-channel encoding sequence (308), a transcription and translation terminator (310), and a PCR reverse primer (312). In various embodiments, the designer proton-channel transgenic algae are used with a gas-separation system (500) and a gas-products-separation and utilization system (600) for photobiological H.sub.2 production.

  12. Consumers' Kansei Needs Clustering Method for Product Emotional Design Based on Numerical Design Structure Matrix and Genetic Algorithms

    Science.gov (United States)

    Chen, Deng-kai; Gu, Rong; Gu, Yu-feng; Yu, Sui-huai

    2016-01-01

    Consumers' Kansei needs reflect their perception about a product and always consist of a large number of adjectives. Reducing the dimension complexity of these needs to extract primary words not only enables the target product to be explicitly positioned, but also provides a convenient design basis for designers engaging in design work. Accordingly, this study employs a numerical design structure matrix (NDSM) by parameterizing a conventional DSM and integrating genetic algorithms to find optimum Kansei clusters. A four-point scale method is applied to assign link weights of every two Kansei adjectives as values of cells when constructing an NDSM. Genetic algorithms are used to cluster the Kansei NDSM and find optimum clusters. Furthermore, the process of the proposed method is presented. The details of the proposed approach are illustrated using an example of electronic scooter for Kansei needs clustering. The case study reveals that the proposed method is promising for clustering Kansei needs adjectives in product emotional design. PMID:27630709

  13. Consumers' Kansei Needs Clustering Method for Product Emotional Design Based on Numerical Design Structure Matrix and Genetic Algorithms.

    Science.gov (United States)

    Yang, Yan-Pu; Chen, Deng-Kai; Gu, Rong; Gu, Yu-Feng; Yu, Sui-Huai

    2016-01-01

    Consumers' Kansei needs reflect their perception about a product and always consist of a large number of adjectives. Reducing the dimension complexity of these needs to extract primary words not only enables the target product to be explicitly positioned, but also provides a convenient design basis for designers engaging in design work. Accordingly, this study employs a numerical design structure matrix (NDSM) by parameterizing a conventional DSM and integrating genetic algorithms to find optimum Kansei clusters. A four-point scale method is applied to assign link weights of every two Kansei adjectives as values of cells when constructing an NDSM. Genetic algorithms are used to cluster the Kansei NDSM and find optimum clusters. Furthermore, the process of the proposed method is presented. The details of the proposed approach are illustrated using an example of electronic scooter for Kansei needs clustering. The case study reveals that the proposed method is promising for clustering Kansei needs adjectives in product emotional design.

  14. New Vistas in Chemical Product and Process Design.

    Science.gov (United States)

    Zhang, Lei; Babi, Deenesh K; Gani, Rafiqul

    2016-06-07

    Design of chemicals-based products is broadly classified into those that are process centered and those that are product centered. In this article, the designs of both classes of products are reviewed from a process systems point of view; developments related to the design of the chemical product, its corresponding process, and its integration are highlighted. Although significant advances have been made in the development of systematic model-based techniques for process design (also for optimization, operation, and control), much work is needed to reach the same level for product design. Timeline diagrams illustrating key contributions in product design, process design, and integrated product-process design are presented. The search for novel, innovative, and sustainable solutions must be matched by consideration of issues related to the multidisciplinary nature of problems, the lack of data needed for model development, solution strategies that incorporate multiscale options, and reliability versus predictive power. The need for an integrated model-experiment-based design approach is discussed together with benefits of employing a systematic computer-aided framework with built-in design templates.

  15. Bovine mammary stem cells: Cell biology meets production agriculture

    Science.gov (United States)

    Mammary stem cells (MaSC) provide for net growth, renewal and turnover of mammary epithelial cells, and are therefore potential targets for strategies to increase production efficiency. Appropriate regulation of MaSC can potentially benefit milk yield, persistency, dry period management and tissue ...

  16. Continued SOFC cell and stack technology and improved production methods

    Energy Technology Data Exchange (ETDEWEB)

    Wandel, M.; Brodersen, K.; Phair, J. (and others)

    2009-05-15

    Within this project significant results are obtained on a number of very diverse areas ranging from development of cell production, metallic creep in interconnect to assembling and test of stacks with foot print larger than 500 cm2. Out of 38 milestones 28 have been fulfilled and 10 have been partly fulfilled. This project has focused on three main areas: 1) The continued cell development and optimization of manufacturing processes aiming at production of large foot-print cells, improving cell performance and development environmentally more benign production methods. 2) Stack technology - especially stacks with large foot print and improving the stack design with respect to flow geometry and gas leakages. 3) Development of stack components with emphasis on sealing (for 2G as well as 3G), interconnect (coat, architecture and creep) and test development. Production of cells with a foot print larger than 500 cm2 is very difficult due to the brittleness of the cells and great effort has been put into this topic. Eight cells were successfully produced making it possible to assemble and test a real stack thereby giving valuable results on the prospects of stacks with large foot print. However, the yield rate is very low and a significant development to increase this yield lies ahead. Several lessons were learned on the stack level regarding 'large foot print' stacks. Modelling studies showed that the width of the cell primarily is limited by production and handling of the cell whereas the length (in the flow direction) is limited by e.g. pressure drop and necessary manifolding. The optimal cell size in the flow direction was calculated to be between approx20 cm and < 30 cm. From an economical point of view the production yield is crucial and stacks with large foot print cell area are only feasible if the cell production yield is significantly enhanced. Co-casting has been pursued as a production technique due to the possibilities in large scale production

  17. Numerical product design: Springback prediction, compensation and optimization

    NARCIS (Netherlands)

    Meinders, T.; Burchitz, I.A.; Bonte, M.H.A.; Lingbeek, R.A.

    2007-01-01

    Numerical simulations are being deployed widely for product design. However, the accuracy of the numerical tools is not yet always sufficiently accurate and reliable. This article focuses on the current state and recent developments in different stages of product design: springback prediction, sprin

  18. 76 FR 56883 - Designation of Product Categories for Federal Procurement

    Science.gov (United States)

    2011-09-14

    ...; pneumatic equipment lubricants; and wood and concrete stains. USDA is also proposing minimum biobased... first is blast media, which may overlap with the EPA-designated recovered content product... EPA-designated recovered content product ``Floor tiles.'' The third is pneumatic equipment...

  19. Organizational Learning and Product Design Management: Towards a Theoretical Model.

    Science.gov (United States)

    Chiva-Gomez, Ricardo; Camison-Zornoza, Cesar; Lapiedra-Alcami, Rafael

    2003-01-01

    Case studies of four Spanish ceramics companies were used to construct a theoretical model of 14 factors essential to organizational learning. One set of factors is related to the conceptual-analytical phase of the product design process and the other to the creative-technical phase. All factors contributed to efficient product design management…

  20. Co-Simulation Technology for Complex Product Design

    Institute of Scientific and Technical Information of China (English)

    熊光楞; 陈小波; 郭滨; 蹇佳; 王成龙

    2002-01-01

    First analyze the simulation requirements in complex product design, then propose the approach to full applying simulation to complex product design, and present the key enable technology with respect to modeling, simulation running, VV&A,evaluation and decision making and supporting platform.

  1. Parametric Collaborative Design of Network-based Mechanical Products

    Institute of Scientific and Technical Information of China (English)

    WU Shu-fang; YU Guo-jun; WANG Zong-yan; SU Tie-xiong; QIN Hui-bin

    2012-01-01

    Aiming at the problems of low-level information sharing, slow transmission and repetitive work in the designing process of product series, the internet-oriented parametric collaborative design method is proposed, in which the problems of sharing conflict and network heterogeneous in the distributed collaborative design are analyzed, and the construction method of collaborative design platforms based on PDMWorks Workgroup is put forward. Through studying the mechanism of roles distribution and function allocation and data concurrency control, the communication mechanism of internet-oriented collaborative design is formulated. On the basis of structure features of overhead travelling crane, through combining parametric variant design with collaborative design, internet-oriented parametric collaborative design system of overhead travelling crane is developed and verified through main girder design. In the paper, the internet-oriented parametric collaborative design method is proposed, aiming to solve the problems of low-level information sharing, slow transmission and repetitive work in the designing process of product series. The problems of sharing conflict and network heterogeneous in the distributed collaborative design are analyzed. The construction method of collaborative design platforms based on PDMWorks Workgroup is put forward. The communication mechanism of internet-oriented collaborative design is formulated, through studying the mechanism of roles distribution and function allocation and data concurrency control. On the basis of structure features of overhead travelling crane, through combining parametric variant design with collaborative design, internet-oriented parametric collaborative design system of overhead travelling crane is developed and verified through main girder design.

  2. From product centered design to value centered design: understanding the value-system

    DEFF Research Database (Denmark)

    Randmaa, Merili; Howard, Thomas J.; Otto, T.

    more value for the customer for less eford. Value and understanding the value-system needs to be in the focus of business strategy. Value can be created, exchanged and perceived. It can be tangible (physical products, money) or intangible (information, experience, relationships, service). Creating......Product design has focused on different parameters through history- design for usability, design for manufacturing, design for assembly etc. Today, as the products get bundled with service, it is important to interconnect product, service and business model design to create synergy effect and offer...

  3. Life-cycle analysis of product integrated polymer solar cells

    DEFF Research Database (Denmark)

    Espinosa Martinez, Nieves; García-Valverde, Rafael; Krebs, Frederik C

    2011-01-01

    economics through design to functionality. An LCA study was performed to quantify the energy use and greenhouse gas (GHG) emissions from electricity use in the manufacture of a light-weight lamp based on a plastic foil, a lithium-polymer battery, a polymer solar cell, printed circuitry, blocking diode......A life cycle analysis (LCA) on a product integrated polymer solar module is carried out in this study. These assessments are well-known to be useful in developmental stages of a product in order to identify the bottlenecks for the up-scaling in its production phase for several aspects spanning from...... on the complete product integrated polymer solar cell. We have compared this portable lighting system with other lighting solutions, namely: a kerosene lamp in a remote rural area in Africa (Ethiopia), as a replacement of a silicon PV based lamp, in place of a torch with non-rechargeable lead-acid battery...

  4. Models and Modelling Tools for Chemical Product and Process Design

    DEFF Research Database (Denmark)

    Gani, Rafiqul

    2016-01-01

    The design, development and reliability of a chemical product and the process to manufacture it, need to be consistent with the end-use characteristics of the desired product. One of the common ways to match the desired product-process characteristics is through trial and error based experiments......-based framework is that in the design, development and/or manufacturing of a chemical product-process, the knowledge of the applied phenomena together with the product-process design details can be provided with diverse degrees of abstractions and details. This would allow the experimental resources......, are the needed models for such a framework available? Or, are modelling tools that can help to develop the needed models available? Can such a model-based framework provide the needed model-based work-flows matching the requirements of the specific chemical product-process design problems? What types of models...

  5. Product Family Design Methodology Using Object-Oriented Approach

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The serious competition environment of global marke t requests the enterprise to change traditional product development strategy and a dopt new theory in order to meet diverse customer needs while maintaining near m ass production efficiency, which is the main philosophy of mass customization. P roduct family design is research focus at present and also is the core technolog y of DFMC (design for mass customization). Firstly, this paper explores the fund amental issues of product family, such as concepts o...

  6. Tetherin restricts productive HIV-1 cell-to-cell transmission.

    Directory of Open Access Journals (Sweden)

    Nicoletta Casartelli

    Full Text Available The IFN-inducible antiviral protein tetherin (or BST-2/CD317/HM1.24 impairs release of mature HIV-1 particles from infected cells. HIV-1 Vpu antagonizes the effect of tetherin. The fate of virions trapped at the cell surface remains poorly understood. Here, we asked whether tetherin impairs HIV cell-to-cell transmission, a major means of viral spread. Tetherin-positive or -negative cells, infected with wild-type or DeltaVpu HIV, were used as donor cells and cocultivated with target lymphocytes. We show that tetherin inhibits productive cell-to-cell transmission of DeltaVpu to targets and impairs that of WT HIV. Tetherin accumulates with Gag at the contact zone between infected and target cells, but does not prevent the formation of virological synapses. In the presence of tetherin, viruses are then mostly transferred to targets as abnormally large patches. These viral aggregates do not efficiently promote infection after transfer, because they accumulate at the surface of target cells and are impaired in their fusion capacities. Tetherin, by imprinting virions in donor cells, is the first example of a surface restriction factor limiting viral cell-to-cell spread.

  7. Empirical modelling for the conceptual design and use of products

    OpenAIRE

    Roe, Chris P.; Beynon, Meurig; Fischer, Carlos N

    2001-01-01

    The process of designing an engineering product usually involves only superficial interaction on the part of the user during the design. This often leads to the product being unsuitable for its target comnmnity. In this paper, we describe an approach called Empirical Modelling that emphasises interaction and experiment throughout the construction of a model that we believe has benefits in respect of usability. We use a case study in digital watch design to illustrate our approach and our ideas.

  8. Design of Formulated Products: Experimental Component

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul; Cheng, Y. S.

    2012-01-01

    : computer-aided design (Stage 1), which generates a list of feasible candidates, experimental planning (Stage 2), which generates a list of experiments and checks the available experimental set-ups, and experimental testing (Stage 3), which measures the necessary data and verifies the desirable attributes...

  9. Explaining the design & styling of future products

    NARCIS (Netherlands)

    Eggink, Wouter; Reinders, Angèle

    2013-01-01

    In many industries technological innovation is the most important driver of competitive success. Within our master curriculum Industrial Design Engineering, we therefore implemented a course that is dedicated to the development of innovative technology. This course, called “Sources of Innovation”, p

  10. Design models in the development of mechatronic products

    DEFF Research Database (Denmark)

    Habib, Tufail; Brunø, Thomas Ditlev; Nielsen, Kjeld

    2012-01-01

    with the aid of models. The role of software not only as part of the product but also in the development process. These models contribute to product structuring and evaluation of design process by reducing the complexity and their use for product customization.......In view of widespread application of mechatronic systems and the competition to offer customized products at high quality and low cost, there has been considerable attention to introduce new methods and models in this regard. This paper explores design process of mechatronic product development...

  11. 77 FR 33269 - Designation of Product Categories for Federal Procurement

    Science.gov (United States)

    2012-06-05

    ..., USDA will then propose new product categories for designation for Federal preferred procurement. USDA... manufacturers that supply only non- qualifying products and do not offer biobased alternatives may experience a... the functional aspects of products identified during the development of this Federal Register...

  12. Establishment of Relationships between Material Design and Product Design Domains by Hybrid FEM-ANN Technique

    CERN Document Server

    Prakash, K Soorya; Raj, M Joseph Malvin

    2010-01-01

    In this paper, research on AI based modeling technique to optimize development of new alloys with necessitated improvements in properties and chemical mixture over existing alloys as per functional requirements of product is done. The current research work novels AI in lieu of predictions to establish association between material and product customary. Advanced computational simulation techniques like CFD, FEA interrogations are made viable to authenticate product dynamics in context to experimental investigations. Accordingly, the current research is focused towards binding relationships between material design and product design domains. The input to feed forward back propagation prediction network model constitutes of material design features. Parameters relevant to product design strategies are furnished as target outputs. The outcomes of ANN shows good sign of correlation between material and product design domains. The study enriches a new path to illustrate material factors at the time of new product d...

  13. A Robust Design Method in Product Quality Applications

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shi-an

    2003-01-01

    In order to express information on the quality grade of product designed, the target value of product quality design was described with a fuzzy number in this paper. An alternative to Taguchi′s, the robustness application design method has been recently presented. However, neither Taguchi′s method nor the alternative method is capable of dealing satisfactorily with the frequently encountered situations in which all the noise variables cannot be studied simultaneously. Based on the ideas from response surface modeling, linear models theory, and random effects models, we provide a method for estimation in the robustness application design method in product quality applications. With this new method used, the high-quality ratio of the product designed could be increased, and the ability to resist the influence of various disturbing factors and noise factors could be enhanced.

  14. Product design enhancement using apparent usability and affective quality.

    Science.gov (United States)

    Seva, Rosemary R; Gosiaco, Katherine Grace T; Santos, Ma Crea Eurice D; Pangilinan, Denise Mae L

    2011-03-01

    In this study, apparent usability and affective quality were integrated in a design framework called the Usability Perception and Emotion Enhancement Model (UPEEM). The UPEEM was validated using structural equation modeling (SEM). The methodology consists of four phases namely product selection, attribute identification, design alternative generation, and design alternative evaluation. The first stage involved the selection of a product that highly involves the consumer. In the attribute identification stage, design elements of the product were identified. The possible values of these elements were also determined for use in the experimentation process. Design of experiments was used to identify how the attributes will be varied in the design alternative stage and which of the attributes significantly contribute to affective quality, apparent usability, and desirability in the design evaluation stage. Results suggest that product attributes related to form are relevant in eliciting intense affect and perception of usability in mobile phones especially those directly related to functionality and aesthetics. This study considered only four product attributes among so many due to the constraints of the research design employed. Attributes related to aesthetic perception of a product enhance apparent usability such as those related to dimensional ratios.

  15. Flow-cytometry and cell sorting: an efficient approach to investigate productivity and cell physiology in mammalian cell factories.

    Science.gov (United States)

    Kumar, Niraj; Borth, Nicole

    2012-03-01

    The performance of cell lines used for the production of biotherapeutic proteins typically depends on the number of cells in culture, their specific growth rate, their viability and the cell specific productivity (qP). Therefore both cell line development and process development are trying to (a) improve cell proliferation to reduce lag-phase and achieve high number of cells; (b) delay cell death to prolong the production phase and improve culture longevity; (c) and finally, increase qP. All of these factors, when combined in an optimised process, concur to increase the final titre and yield of the recombinant protein. As cellular performance is at the centre of any improvement, analysis methods that enable the characterisation of individual cells in their entirety can help in identifying cell types and culture conditions that perform exceptionally well. This observation of cells and their complexity is reflected by the term "cytomics" and flow cytometry is one of the methods used for this purpose. With its ability to analyse the distribution of physiological properties within a population and to isolate rare outliers with exceptional properties, flow cytometry ideally complements other methods used for optimisation, including media design and cell engineering. In the present review we describe approaches that could be used, directly or indirectly, to analyse and sort cellular phenotypes characterised by improved growth behaviour, reduced cell death or high qP and outline their potential use for cell line and process optimisation.

  16. Production Quality Control Of Microfluidic Chip Designs

    DEFF Research Database (Denmark)

    Calaon, Matteo; Hansen, Hans Nørgaard; Tosello, Guido

    2012-01-01

    -beam lithography. Subsequent nickel electroplating was employed to replicate the obtained geometries on the tool, which was used to mold on transparent polymer substrates the functional structures. To assess the critical factors affecting the replication quality throughout the different steps of the proposed...... process chain, test geometries were designed and produced on the side of the functional features. The so called “Finger Print” of the lithography and molding processes was qualitatively and quantitatively evaluated through scanning electron microscopy and atomic force microscopy respectively. The entire...

  17. A Design of Product Collaborative Online Configuration Model

    Science.gov (United States)

    Wang, Xiaoguo; Zheng, Jin; Zeng, Qian

    According to the actual needs of mass customization, the personalization of product and its collaborative design, the paper analyzes and studies the working mechanism of modular-based product configuration technology and puts forward an information model of modular product family. Combined with case-based reasoning techniques (CBR) and the constraint satisfaction problem solving techniques (CSP), we design and study the algorithm for product configuration, and analyze its time complexity. A car chassis is made as the application object, we provide a prototype system of online configuration. Taking advantage of this system, designers can make appropriate changes on the existing programs in accordance with the demand. This will accelerate all aspects of product development and shorten the product cycle. Also the system will provide a strong technical support for enterprises to improve their market competitiveness.

  18. Integrating Emotional Attachment and Sustainability in Electronic Product Design

    Directory of Open Access Journals (Sweden)

    Alex Lobos

    2013-03-01

    Full Text Available Current models for Information and Communication Technology (ICT products encourage frequent product replacement with newer versions that offer only minor incremental improvements. This pattern, named planned obsolescence, diminishes user experience and shortens product lifespan. This paper presents the conceptual basis for a two-part integrated approach to combating planned obsolescence in ICT devices. First, design for emotional attachment, which creates products that users enjoy, value, and use for longer. Second, technological adaptability, which anticipates product upgrades and repairs as new technologies emerge. A model interdisciplinary design course in industrial design and sustainability, also described herein, trains students to apply this approach to create innovative ICT products with smaller environmental footprints.

  19. Designer as Ethnographer: A Study of Domestic Cooking and Heating Product Design for Irish Older Adults

    OpenAIRE

    2012-01-01

    In many ways, the design of domestic cooking and heating products reflects the zeitgeist of Irish culture throughout the 20th and into the 21st century. From domesticity to materialism, these products have evolved to meet fundamental human needs within the home. Concurrent with this, the methods and processes designers use to create domestic artefacts have evolved and changed. The emergence of Design Ethnography illustrates an evolution where Design has appropriated an establis...

  20. Characteristics affecting management of design information in the production system design process

    OpenAIRE

    Bruch, Jessica; Bellgran, Monica

    2013-01-01

    Although it has been argued that the design of production systems is crucial, there is a general lack of empirical studies analysing and identifying resources and capabilities required for an efficient production system design process. One of these resources is the critical role attributed to design information and one such capability is how the design information is managed. To address this research gap, this paper reports the results from two in-depth case studies in the automotive industry...

  1. Using “Styling” Conceptual Tool In Product Design: A Product Semantic Approach

    Directory of Open Access Journals (Sweden)

    Çınar Narter

    2013-12-01

    Full Text Available Industrial design "styling" concept is generally described as the "Products altering the basic structural elements between the forms of perception”. Referred to here "perception", wants to give the message to be aware of or understand the product. Repeated a number of forms that create the perception occurs through a kind of product has led to the design. At this point, we must not mix up the styling and design. Design does not mean styling. Styling of the product does not mean that the external appearance and give shape to the shell. Styling Applications; cognitive sciences, hybrid technologies, is kept in sight, out of human psychological and physical needs of the state and includes the creation of form over function causality. "Styling" in Turkish is also referred as "shaping" and "stylization". In this article, under the discipline of Industrial Design "Semantic Concept Tools" and the "Design" is one of the methods of "styling" the implications of the concept of product design applications. In terms of product identification, products to reflect the context in which the concept of design and semantic approach to styling products that is passed out of the ways in which a study intended to convey messages included. In this study, the relationship between the disciplines of product design semantics,in the field of science and industry are established.

  2. Artefact specification, design, and production as a process of communication

    DEFF Research Database (Denmark)

    Galle, Per

    1999-01-01

    for the success of communication carry over to the artefact production process. The purpose of the analysis is to provide a conceptual background for the study of various aspects of artefact production, such as design, or the development of computer-based tools for collaborative design, product modelling......The co-operative process of specifying, designing, and producing an artefact is analysed in terms of communication among the agents involved. By way of introduction, I offer a brief analysis of communication in general, outlining conditions for its success, while avoiding simplistic assumptions...

  3. The power of design product innovation in sustainable energy technologies

    CERN Document Server

    Reinders, Angele H; Brezet, Han

    2012-01-01

    The Power of Design offers an introduction and a practical guide to product innovation, integrating the key topics that are necessary for the design of sustainable and energy-efficient products using sustainable energy technologies. Product innovation in sustainable energy technologies is an interdisciplinary field. In response to its growing importance and the need for an integrated view on the development of solutions, this text addresses the functional principles of various energy technologies next to the latest design processes and innovation methods. From the perspec

  4. Double Image Design in Newspaper Production

    Directory of Open Access Journals (Sweden)

    Mario Barišić

    2010-01-01

    Full Text Available In the high circulation production of daily newspapers, a double image, double information is set under the rules of Infraredesign theory (Pap et al, 2010. The management of visible and near infrared is posted with process colors for color setting configured for conventional newspaper print. The place of imprint that has delimited information in vs (Visible Spectrum and nir (Near InfraRed is called “a print with an infrared effect,” or conditionally “a print with infrared colors.” Daily newspapers, as massive carriers of information made by printing technique, are receiving a new form of presentation: printed image with a built-in invisible image.

  5. Virtual Manufacturing : Tools for improving Design and Production

    CERN Document Server

    Dépincé, Philippe; Woelk, Peer-Oliver

    2007-01-01

    The research area "Virtual Manufacturing" can be defined as an integrated manufacturing environment which can enhance one or several levels of decision and control in manufacturing process. Several domains can be addressed: Product and Process Design, Process and Production Planning, Machine Tool, Robot and Manufacturing System. As automation technologies such as CAD/CAM have substantially shortened the time required to design products, Virtual Manufacturing will have a similar effect on the manufacturing phase thanks to the modelling, simulation and optimisation of the product and the processes involved in its fabrication.

  6. Design for Usability; practice-oriented research for user-centered product design.

    Science.gov (United States)

    van Eijk, Daan; van Kuijk, Jasper; Hoolhorst, Frederik; Kim, Chajoong; Harkema, Christelle; Dorrestijn, Steven

    2012-01-01

    The Design for Usability project aims at improving the usability of electronic professional and consumer products by creating new methodology and methods for user-centred product development, which are feasible to apply in practice. The project was focused on 5 key areas: (i) design methodology, expanding the existing approach of scenario-based design to incorporate the interaction between product design, user characteristics, and user behaviour; (ii) company processes, barriers and enablers for usability in practice; (iii) user characteristics in relation to types of products and use-situations; (iv) usability decision-making; and (v) product impact on user behaviour. The project team developed methods and techniques in each of these areas to support the design of products with a high level of usability. This paper brings together and summarizes the findings.

  7. Design of systems for productivity and well being

    DEFF Research Database (Denmark)

    Edwards, Kasper; Jensen, Per Langaa

    2014-01-01

    It has always been an ambition within the ergonomic profession to ensure that design or redesign of production systems consider both productivity and employee well being, but there are many approaches to how to achieve this. This paper identifies the basic issues to be addressed in light of some...... research activities at DTU, especially by persons responsible for facilitating design processes. Four main issues must be addressed: (1) determining the limits and scope of the system to be designed; (2) identifying stakeholders related to the system and their role in the system design; (3) handling...

  8. On Adaptive Extended Compatibility Changing Type of Product Design Strategy

    Science.gov (United States)

    Wenwen, Jiang; Zhibin, Xie

    The article uses research ways of Enterprise localization and enterprise's development course to research strategy of company's product design and development. It announces at different stages for development, different kinds of enterprises will adopt product design and development policies of different modes. It also announces close causality between development course of company and central technology and product. The result indicated enterprises in leading position in market, technology and brand adopt pioneer strategy type of product research and development. These enterprise relying on the large-scale leading enterprise offering a complete set service adopts the passively duplicating type tactic of product research and development. Some enterprise in part of advantage in technology, market, management or brand adopt following up strategy of product research and development. The enterprises with relative advantage position adopt the strategy of technology applied taking optimizing services as centre in product research and development in fields of brand culture and market service.

  9. Designing for Dynamic Usability: Development of a Design Method that Supports Designing Products for Dynamic Use Situations

    NARCIS (Netherlands)

    Bijl-Brouwer, van der Mieke; Voort, van der Mascha C.

    2008-01-01

    Ease of use or usability is gaining ground as a selling argument. However, designing usable consumer products still remains a complicated activity, particularly when products will be used in changing circumstances. The usability of a product is defined by ISO 9241 as the extent to which a product ca

  10. An Innovative Methodology of Product Design from Nature

    Institute of Scientific and Technical Information of China (English)

    Hui-I Wen; Shu-jun Zhang; Kevin Hapeshi; Xiao-feng Wang

    2008-01-01

    Nature is an information sourcebeok of behaviour, function, colour and shape which can inspire visual design and invention. Studying the form and functional characteristics of a natural object can provide inspiration for product design and help to improve the marketability of manufactured products. The inspiration can be triggered either by direct observation or captured by threo-dimensional (3D) digitising techniques to obtain superficial information (geometry and colour). An art designer often creates a concept in the form of a two-dimensional (2D) sketch while engineering methods lead to a point cloud in 3D. Each has its limitations in that the art designer commonly lacks the knowledge to build a final product from a 2D sketch and the engineering designer's 3D point clouds may not be very beautiful. We propose a method for Product Design from Nature (PDN),coupling aesthetic intent and geometrical characteristics, exploring the interactions between designers and nature's systems in PDN. We believe that this approach would considerably reduce the lead time and cost of product design from nature.

  11. The Process of Optimizing Mechanical Sound Quality in Product Design

    DEFF Research Database (Denmark)

    Eriksen, Kaare; Holst, Thomas

    2011-01-01

    clarify the importance of product sound, defining perceptive demands identified by users, and, finally, how to suggest mechanical principles for modification of an existing sound design. The optimized mechanical sound design is followed by tests on users of the product in its use context. The result......The research field concerning optimizing product sound quality is a relatively unexplored area, and may become difficult for designers to operate in. To some degree, sound is a highly subjective parameter, which is normally targeted sound specialists. This paper describes the theoretical...... and practical background for managing a process of optimizing the mechanical sound quality in a product design by using simple tools and workshops systematically. The procedure is illustrated by a case study of a computer navigation tool (computer mouse or mouse). The process is divided into 4 phases, which...

  12. idSpace: Supporting Designers to develop Innovative Products

    NARCIS (Netherlands)

    Sloep, Peter; Bitter-Rijpkema, Marlies; Retalis, Symeon; Georgiakakis, Petros; Dolog, Peter

    2009-01-01

    Sloep, P., Bitter-Rijpkema, M., Retalis, S., Georgiakakis, P., & Dolog, P. (2008). idSpace: Supporting Designers to develop Innovative Products. Presentation at Online Educa. December, 3, 2008. Berlin, Germany.

  13. Fuel cell cathode air filters: Methodologies for design and optimization

    Science.gov (United States)

    Kennedy, Daniel M.; Cahela, Donald R.; Zhu, Wenhua H.; Westrom, Kenneth C.; Nelms, R. Mark; Tatarchuk, Bruce J.

    Proton exchange membrane (PEM) fuel cells experience performance degradation, such as reduction in efficiency and life, as a result of poisoning of platinum catalysts by airborne contaminants. Research on these contaminant effects suggests that the best possible solution to allowing fuel cells to operate in contaminated environments is by filtration of the harmful contaminants from the cathode air. A cathode air filter design methodology was created that connects properties of cathode air stream, filter design options, and filter footprint, to a set of adsorptive filter parameters that must be optimized to efficiently operate the fuel cell. Filter optimization requires a study of the trade off between two causal factors of power loss: first, a reduction in power production due to poisoning of the platinum catalyst by chemical contaminants and second, an increase in power requirements to operate the air compressor with a larger pressure drop from additional contaminant filtration. The design methodology was successfully applied to a 1.2 kW fuel cell using a programmable algorithm and predictions were made about the relationships between inlet concentration, breakthrough time, filter design, pressure drop, and compressor power requirements.

  14. Design and Realization of the Safety Production Scheduling System

    Directory of Open Access Journals (Sweden)

    Qiang Fan

    2013-01-01

    Full Text Available In this study, we have a research of the design and realization of the Safety Production Scheduling System. Urged by the government departments as well as safety supervising institutions, many coal enterprises are embarking on designing and constructing an information system platform for safety production and scheduling. How to establish a systematic, comprehensive, standardized and scientific management platform for the safety production and scheduling has become a hot issue in the coal industry, which is also an important move to integrate various safety management measures in order to prevent major safety accidents and keep up with the international industry status. Taking a successful, large-scale safety production and scheduling system for example, this study elaborates on its overall design and construction. When the system is completed, it will play an important role in strengthening safety production of the coal mines, preventing accidents as well as increasing the overall safety level of the coal industry.

  15. Property Based Process and Product Synthesis and Design

    DEFF Research Database (Denmark)

    Eden, Mario Richard

    2003-01-01

    This thesis describes the development of a general framework for solving process and product design problems. Targeting the desired performance of the system in a systematic manner relieves the iterative nature of conventional design techniques. Furthermore, conventional component based methods...... roles a property model plays at different stages of the solution to a design problem, it is discovered that by decoupling the constitutive equations, that make up the property model, from the balance and constraint equations of the process or product model, a significant reduction in problem complexity...... in terms of the constitutive (synthesis/design) variables instead of the process variables, thus providing the synthesis/design targets. The second reverse problem (reverse property prediction) solves the constitutive equations to identify unit operations, operating conditions and/or products by matching...

  16. Collaborative Product Design for Tasks Sorting Based on Shortest Delivery

    Directory of Open Access Journals (Sweden)

    Xuedong Liang

    2016-01-01

    Full Text Available The “people’s innovation” can promote development in enterprises in urgent need of innovative product design. Collaborative product design can be a powerful tool for enterprises wishing to improve their market competitiveness and customer satisfaction. To reduce decision costs, improve efficiency, and solve other issues, promoting “people’s innovation” can play a vital role. With this focus, this paper examines products produced through “people’s innovation.” A collaborative design task scheduling problem is presented. The design tasks are sorted based on a minimum delivery cost principle, which is determined using weighted shortest processing time (WSPT rules and the shortest delivery time. The results show that distributed collaborative innovation can result in a reasonable arrangement for collaborative design tasks.

  17. Product Modelling for Building Design: Annotated Bibliography (2nd Edition)

    DEFF Research Database (Denmark)

    Galle, Per

    1999-01-01

    This bibliography concerns research publications from 1976 to 1994-5, on product modelling in computer aided architectural design and computer aided engineering design of buildings and their surroundings. For each item of literature, full bibliographic information is given whenever available...... of literature is offered on machine interpretation of drawings, which may be relevant in the context of information exchange among different product models. Although the bibliography is fairly comprehensive as far as it goes, no completeness of coverage is claimed....

  18. Comparing Personal Characteristic Factors of Imagination between Expert and Novice Designers within Different Product Design Stages

    Science.gov (United States)

    Huang, Yinghsiu; Li, Jianyou

    2015-01-01

    Imagination plays a key role in various domains in helping to create innovative ideas, drawings, poems, movies, products, etc. In product design domain, the personal characteristics of imagination are crucial abilities for conceiving novel ideas during design processes. This study focuses on personal characteristic differences and similarities…

  19. Design for usability: practice oriented research for user-centered product design

    NARCIS (Netherlands)

    Eijk, van D.; Hoolhorst, F.W.B.; Kim, F.; Harkema, C.; Dorrestijn, S.; Kuijk, van J.

    2012-01-01

    The Design for Usability project aims at improving the usability of electronic professional and consumer products by creating new methodology and methods for user-centred product development, which are feasible to apply in practice. The project was focused on 5 key areas: (i) design methodology, exp

  20. Low power and reliable SRAM memory cell and array design

    CERN Document Server

    Ishibashi, Koichiro

    2011-01-01

    Success in the development of recent advanced semiconductor device technologies is due to the success of SRAM memory cells. This book addresses various issues for designing SRAM memory cells for advanced CMOS technology. To study LSI design, SRAM cell design is the best materials subject because issues about variability, leakage and reliability have to be taken into account for the design.

  1. Design for Health and Well Being: Knitted Products for Diabetics

    Science.gov (United States)

    Gault, A.

    2016-07-01

    This paper will discuss the design development, manufacturing and testing of knitted products maximizing the use of new innovations in Nano- technology and the integration of Phase Changing Materials specifically for diabetics. The project identified key aspects requiring design solutions to bring improvement to the circulatory problems with specific reference to the diabetic condition. Diabetics have particular difficulty in regulating their body temperature and this can result in the condition worsening, and resulting in loss of digits or limbs. The design of products to prevent the deterioration of the diabetic condition and to help those with limb loss was developed in collaboration with a Northern Ireland diabetic consultant, a product engineer and a knitwear designer. The fusion of ideas between the stakeholders resulted in the development and manufacture of a range of products that have been successfully tested at the yarn and fabric development stage and have been proven to maintain body temperature by either cooling or warming and therefore bring improvement to health and well-being. Whilst the product has a performance element the design ideas created desirable products that not only provided solutions to the brief but also resulted in products that had further market applications.

  2. Practical design and production of optical thin films

    CERN Document Server

    Willey, Ronald R

    2002-01-01

    Fundamentals of Thin Film Optics and the Use of Graphical Methods in Thin Film Design Estimating What Can Be Done Before Designing Fourier Viewpoint of Optical Coatings Typical Equipment for Optical Coating Production Materials and Process Know-How Process Development Monitoring and Control of Thin Film Growth Appendix: Metallic and Semiconductor Material Graphs Author IndexSubject Index

  3. Structural optimization for materially informed design to robotic production processes

    NARCIS (Netherlands)

    Bier, H.H.; Mostafavi, S.

    2015-01-01

    Hyperbody’s materially informed Design-to-Robotic-Production (D2RP) processes for additive and subtractive manufacturing aim to achieve performative porosity in architecture at various scales. An extended series of D2RP experiments aiming to produce prototypes at 1:1 scale wherein design materiality

  4. Synthetic Environments as visualization method for product design

    NARCIS (Netherlands)

    Meijer, Frank; Broek, van den Egon L.; Schouten, Theo E.; Damgrave, Roy G.J.; Ridder, de Huib; Rogowitz, Bernice E.; Pappas, Thrasyvoulos N.

    2010-01-01

    In this paper, we explored the use of low fidelity Synthetic Environments (SE; i.e., a combination of simulation techniques) for product design. We explored the usefulness of low fidelity SE to make design problems explicit. In particular, we were interested in the influence of interactivity on user

  5. Synthetic environments as visualization method for product design

    NARCIS (Netherlands)

    Meijer, F.; Van den Broek, E.L.; Schouten, T.E.; Damgrave, R.G.J.; De Ridder, H.

    2010-01-01

    In this paper, we explored the use of low fidelity Synthetic Environments (SE; i.e., a combination of simulation techniques) for product design. We explored the usefulness of low fidelity SE to make design problems explicit. In particular, we were interested in the influence of interactivity on user

  6. Product quality driven design of bakery operations using dynamic optimization

    NARCIS (Netherlands)

    Hadiyanto, M.; Esveld, D.C.; Boom, R.M.; Straten, van G.; Boxtel, van A.J.B.

    2008-01-01

    Abstract Quality driven design uses specified product qualities as a starting point for process design. By backward reasoning the required process conditions and processing system were found. In this work dynamic optimization was used as a tool to generate processing solutions for baking processes b

  7. Design of systems for productivity and well being.

    Science.gov (United States)

    Edwards, Kasper; Jensen, Per Langaa

    2014-01-01

    It has always been an ambition within the ergonomic profession to ensure that design or redesign of production systems consider both productivity and employee well being, but there are many approaches to how to achieve this. This paper identifies the basic issues to be addressed in light of some research activities at DTU, especially by persons responsible for facilitating design processes. Four main issues must be addressed: (1) determining the limits and scope of the system to be designed; (2) identifying stakeholders related to the system and their role in the system design; (3) handling the process' different types of knowledge; and (4) emphasizing that performance management systems, key performance indicators (KPIs), and leadership are also part of the system design and must be given attention. With the examples presented, we argue that knowledge does exist to help system design facilitators address these basic issues.

  8. Design for Environment: opportunities in supply chain network and product design

    OpenAIRE

    Chen, Yifen

    2013-01-01

    This dissertation contributes to the sustainability literature by incorporating a systematic analysis to provide guidelines to sustainable design. During the design phase, there is a great potential to manage the environmental impacts of the whole product life cycle. However, decision making in the design phase is usually complicated. Therefore, a holistic system analysis with the consideration of relevant factors in the whole product life cycle is needed. In this dissertation, a life-cycle t...

  9. Cell-Free Synthesis Meets Antibody Production: A Review

    Directory of Open Access Journals (Sweden)

    Marlitt Stech

    2015-01-01

    Full Text Available Engineered antibodies are key players in therapy, diagnostics and research. In addition to full size immunoglobulin gamma (IgG molecules, smaller formats of recombinant antibodies, such as single-chain variable fragments (scFv and antigen binding fragments (Fab, have emerged as promising alternatives since they possess different advantageous properties. Cell-based production technologies of antibodies and antibody fragments are well-established, allowing researchers to design and manufacture highly specific molecular recognition tools. However, as these technologies are accompanied by the drawbacks of being rather time-consuming and cost-intensive, efficient and powerful cell-free protein synthesis systems have been developed over the last decade as alternatives. So far, prokaryotic cell-free systems have been the focus of interest. Recently, eukaryotic in vitro translation systems have enriched the antibody production pipeline, as these systems are able to mimic the natural pathway of antibody synthesis in eukaryotic cells. This review aims to overview and summarize the advances made in the production of antibodies and antibody fragments in cell-free systems.

  10. Human experience and product usability: principles to assist the design of user-product interactions.

    Science.gov (United States)

    Chamorro-Koc, Marianella; Popovic, Vesna; Emmison, Michael

    2009-07-01

    This paper introduces research that investigates how human experience influences people's understandings of product usability. It describes an experiment that employs visual representation of concepts to elicit participants' ideas of a product's use. Results from the experiment lead to the identification of relationships between human experience, knowledge, and context-of-use--relationships that influence designers' and users' concepts of product usability. These relationships are translated into design principles that inform the design activity with respect to the aspects of experience that trigger people's understanding of a product's use. A design tool (ECEDT) is devised to aid designers in the application of these principles. This tool is then trialled in the context of a design task in order to verify applicability of the findings.

  11. DEFICIENT INFORMATION MODELING OF MECHANICAL PRODUCTS FOR CONCEPTUAL SHAPE DESIGN

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In allusion to the deficient feature of product information in conceptual design, a framework of deficient information modeling for conceptual shape design is put forward, which includes qualitative shape modeling (a qualitative solid model), uncertain shape modeling (an uncertain relation model) and imprecise shape modeling (an imprecise region model). In the framework, the qualitative solid model is the core, which represents qualitatively (using symbols) the conceptual shapes of mechanical products. The uncertain relation model regarding domain relations as objects and the imprecise region model regarding domains as objects are used to deal with the uncertain and imprecise issues respectively, which arise from qualitative shape modeling or exist in product information itself.

  12. Product design and development for dinner chair of Kansei Engineering

    Directory of Open Access Journals (Sweden)

    Sirichai Yodwangjai

    2014-06-01

    Full Text Available This research investigated the customer’s perception and product properties. The semantic differential method was employed to examine the relationship between customer’s perception and product properties. Fifty-six dinner chairs are selected from website, magazine and publishing and 10 SD words. The product properties divided 8 groups and 34 sub-groups. The new model created base on Quantification Theory Type 1. The research results show 3 high perceptions: comfortable, soft and modern. The research is expected to help support the designer to design a new model that satisfied the customer’s perception.

  13. Software Product Line for TVDi applications based on design patterns

    Directory of Open Access Journals (Sweden)

    Mirtha Fabiana Miranda

    2016-08-01

    Full Text Available The development of high quality interactive applications for Digital TV (TVDi in industrial scale, requires specific strategies that can be applied in order to develop them. From patterns of interaction design, based on the user, a Software Product Line (SPL for TVDi applications it is proposed to be built. SPL is a form of software development focused on promoting re-using and design patterns of interaction that guarantee the management of products. This project work presents the characteristics of an SPL in order to domain interactive applications for Digital TV, which were validated, mostly based on 32 prototypes, that apply design patterns of interaction based on the user.

  14. Exploring the influence of design culture on ICT healthcare product and service design for rural China

    NARCIS (Netherlands)

    Jiang, J.; Kandachar, P.V.; Freudenthal, A.

    2010-01-01

    Design culture is usually considered as one of the important aspects that influence designers’ decisions and actions, especially in Design for Base of the Pyramid projects including ICT Healthcare Product Design in Rural China (IHDRC). There are two research questions in this issue: what are the cul

  15. Generic Development of Topical Dermatologic Products, Part II: Quality by Design for Topical Semisolid Products

    OpenAIRE

    Chang, Rong-Kun; Raw, Andre; Lionberger, Robert; Yu, Lawrence

    2013-01-01

    The emergence of quality by design as a relatively new systematic science and risk-based approach has added a new dimension to pharmaceutical development and manufacturing. This review attempts to discuss the quality by design elements and concepts applied for topical semisolid products. Quality by design begins with defining a quality target product profile as well as critical quality attributes. Subsequently, this is followed by risk identification/risk analysis/risk evaluation to recognize...

  16. Developing a Decision Model of Sustainable Product Design and Development from Product Servicizing in Taiwan

    Science.gov (United States)

    Huang, Yu-Chen; Tu, Jui-Che; Hung, So-Jeng

    2016-01-01

    In response to the global trend of low carbon and the concept of sustainable development, enterprises need to develop R&D for the manufacturing of energy-saving and sustainable products and low carbon products. Therefore, the purpose of this study was to construct a decision model for sustainable product design and development from product…

  17. Customization Product Design Based on User's Emotion and Needs

    Institute of Scientific and Technical Information of China (English)

    JIN Chun; ZHANG Chun-lin; LIU Wen-zhi

    2005-01-01

    The paper presents a design method that ensures the ingenuity of the product form as well as the whole and exact expression of user's needs. The key idea is to establish an automatic design system which can transform the users language needs into the product features in real-time. A rifle was taken as a research instance and soldiers were chosen as evaluation customers. The theory of fuzzy set and semantic difference are adopted to evaluate the relationship between user's needs and product features as well as their alternatives. FAHP (fuzzy analytic hierarchy process) is utilized to judge the users satisfactory forms. This method can also be applied to other product form designs.

  18. Designing low-complexity electrical consumer products for ecological use.

    Science.gov (United States)

    Sauer, Juergen; Wiese, Bettina S; Rüttinger, Bruno

    2003-11-01

    This study examined the environmental impact of low-complexity electrical consumer products during their use in a domestic context. In the experimental scenario, 48 users were asked to use a kettle under different conditions. On-product information (OPI), task instruction, and kettle design were employed as independent variables in a mixed multi-factorial design to examine their effects on different parameters of ecological performance (e.g., water and electricity consumption). Measures of user variables (environmental concern, knowledge, domestic habits, environmental control beliefs) were also taken to examine their relationship with performance parameters. The results revealed main effects of ecological task instruction, OPI and (partly) kettle design on ecological user behaviour. Habits, environmental concern and control beliefs were found to be related to performance parameters whereas knowledge was not. The implications of the results for product design are discussed against the background of a strong prevalence of habits and low ecological user motivation.

  19. Innovative Product Design Based on Customer Requirement Weight Calculation Model

    Institute of Scientific and Technical Information of China (English)

    Chen-Guang Guo; Yong-Xian Liu; Shou-Ming Hou; Wei Wang

    2010-01-01

    In the processes of product innovation and design, it is important for the designers to find and capture customer's focus through customer requirement weight calculation and ranking. Based on the fuzzy set theory and Euclidean space distance, this paper puts forward a method for customer requirement weight calculation called Euclidean space distances weighting ranking method. This method is used in the fuzzy analytic hierarchy process that satisfies the additive consistent fuzzy matrix. A model for the weight calculation steps is constructed;meanwhile, a product innovation design module on the basis of the customer requirement weight calculation model is developed. Finally, combined with the instance of titanium sponge production, the customer requirement weight calculation model is validated. By the innovation design module, the structure of the titanium sponge reactor has been improved and made innovative.

  20. Application of Hydrodynamics in Design of Flotation Deinking Cell

    Science.gov (United States)

    Li, R. G.; Xie, X. F.; Wang, A. L.; Chen, K. F.

    Recovery and recycling of waste paper has become increasingly important with demand for paper products sharply growing. The flotation process is the predominant technology for the removal of inks from waste paper because of its advantages. Flotation cells may be very different in size and shape, but the key elements ensuring aeration, ink collection and bubble separation are always present. Different aeration systems have been developed by the equipment suppliers. The hydrodynamic method, based on the self suction and mixing of air according to the Venturi principle has become the most common aeration technique. Injectors of various sizes and designs have been investigated and constantly improved and adapted to different designs of flotation units. Step diffuser is a common and predominant injector used in the flotation deinking cell.

  1. Design and development of synthetic microbial platform cells for bioenergy.

    Science.gov (United States)

    Lee, Sang Jun; Lee, Sang-Jae; Lee, Dong-Woo

    2013-01-01

    The finite reservation of fossil fuels accelerates the necessity of development of renewable energy sources. Recent advances in synthetic biology encompassing systems biology and metabolic engineering enable us to engineer and/or create tailor made microorganisms to produce alternative biofuels for the future bio-era. For the efficient transformation of biomass to bioenergy, microbial cells need to be designed and engineered to maximize the performance of cellular metabolisms for the production of biofuels during energy flow. Toward this end, two different conceptual approaches have been applied for the development of platform cell factories: forward minimization and reverse engineering. From the context of naturally minimized genomes,non-essential energy-consuming pathways and/or related gene clusters could be progressively deleted to optimize cellular energy status for bioenergy production. Alternatively, incorporation of non-indigenous parts and/or modules including biomass-degrading enzymes, carbon uptake transporters, photosynthesis, CO2 fixation, and etc. into chassis microorganisms allows the platform cells to gain novel metabolic functions for bioenergy. This review focuses on the current progress in synthetic biology-aided pathway engineering in microbial cells and discusses its impact on the production of sustainable bioenergy.

  2. Design and Development of Synthetic Microbial Platform Cells for Bioenergy

    Directory of Open Access Journals (Sweden)

    Sang Jun eLee

    2013-04-01

    Full Text Available The finite reservation of fossil fuels accelerates the necessity of development of renewable energy sources. Recent advances in synthetic biology encompassing systems biology and metabolic engineering enable us to engineer and/or create tailor made microorganisms to produce alternative biofuels for the future bio-era. For the efficient transformation of biomass to bioenergy, microbial cells need to be designed and engineered to maximize the performance of cellular metabolisms for the production of biofuels during energy flow. Toward this end, two different conceptual approaches have been applied for the development of platform cell factories: forward minimization and reverse engineering. From the context of naturally minimized genomes, non-essential energy-consuming pathways and/or related gene clusters could be progressively deleted to optimize cellular energy status for bioenergy production. Alternatively, incorporation of non-indigenous parts and/or modules including biomass degrading enzymes, carbon uptake transporters, photosynthesis, CO2 fixation, and etc. into chassis microorganisms allows the platform cells to gain novel metabolic functions for bioenergy. This review focuses on the current progress in synthetic biology-aided pathway engineering in microbial cells and discusses its impact on the production of sustainable bioenergy.

  3. Designed Amino Acid Feed in Improvement of Production and Quality Targets of a Therapeutic Monoclonal Antibody.

    Directory of Open Access Journals (Sweden)

    Fatemeh Torkashvand

    Full Text Available Cell culture feeds optimization is a critical step in process development of pharmaceutical recombinant protein production. Amino acids are the basic supplements of mammalian cell culture feeds with known effect on their growth promotion and productivity. In this study, we reported the implementation of the Plackett-Burman (PB multifactorial design to screen the effects of amino acids on the growth promotion and productivity of a Chinese hamster ovary DG-44 (CHO-DG44 cell line producing bevacizumab. After this screening, the amino acid combinations were optimized by the response surface methodology (RSM to determine the most effective concentration in feeds. Through this strategy, the final monoclonal antibody (mAb titre was enhanced by 70%, compared to the control group. For this particular cell line, aspartic acid, glutamic acid, arginine and glycine had the highest positive effects on the final mAb titre. Simultaneously, the impact of the designed amino acid feed on some critical quality attributes of bevacizumab was examined in the group with highest productivity. The product was analysed for N-glycan profiles, charge variant distribution, and low molecular weight forms. The results showed that the target product quality has been improved using this feeding strategy. It was shown how this strategy could significantly diminish the time and number of experiments in identifying the most effective amino acids and related concentrations in target product enhancement. This model could be successfully applied to other components of culture media and feeds.

  4. Effect of microwell chip structure on cell microsphere production of various animal cells.

    Science.gov (United States)

    Sakai, Yusuke; Yoshida, Shirou; Yoshiura, Yukiko; Mori, Rhuhei; Tamura, Tomoko; Yahiro, Kanji; Mori, Hideki; Kanemura, Yonehiro; Yamasaki, Mami; Nakazawa, Kohji

    2010-08-01

    The formation of three-dimensional cell microspheres such as spheroids, embryoid bodies, and neurospheres has attracted attention as a useful culture technique. In this study, we investigated a technique for effective cell microsphere production by using specially prepared microchip. The basic chip design was a multimicrowell structure in triangular arrangement within a 100-mm(2) region in the center of a polymethylmethacrylate (PMMA) plate (24x24 mm(2)), the surface of which was modified with polyethylene glycol (PEG) to render it nonadhesive to cells. We also designed six similar chips with microwell diameters of 200, 300, 400, 600, 800, and 1000 microm to investigate the effect of the microwell diameter on the cell microsphere diameter. Rat hepatocytes, HepG2 cells, mouse embryonic stem (ES) cells, and mouse neural progenitor/stem (NPS) cells formed hepatocyte spheroids, HepG2 spheroids, embryoid bodies, and neurospheres, respectively, in the microwells within 5 days of culture. For all the cells, a single microsphere was formed in each microwell under all the chip conditions, and such microsphere configurations remained throughout the culture period. Furthermore, the microsphere diameters of each type of cell were strongly positively correlated with the microwell diameters of the chips, suggesting that microsphere diameter can be factitiously controlled by using different chip conditions. Thus, this chip technique is a promising cellular platform for tissue engineering or regenerative medicine research, pharmacological and toxicological studies, and fundamental studies in cell biology.

  5. Generic development of topical dermatologic products, Part II: quality by design for topical semisolid products.

    Science.gov (United States)

    Chang, Rong-Kun; Raw, Andre; Lionberger, Robert; Yu, Lawrence

    2013-07-01

    The emergence of quality by design as a relatively new systematic science and risk-based approach has added a new dimension to pharmaceutical development and manufacturing. This review attempts to discuss the quality by design elements and concepts applied for topical semisolid products. Quality by design begins with defining a quality target product profile as well as critical quality attributes. Subsequently, this is followed by risk identification/risk analysis/risk evaluation to recognize critical material attributes and critical process parameters, in conjunction with design of experiments or other appropriate methods to establish control strategies for the drug product. Several design-of-experiment examples are included as practical strategies for the development and optimization of formulation and process for topical drug products.

  6. Systematic Methodology for Design of Tailor-Made Blended Products: Fuels and Other Blended Products

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza Binti

    important in daily life, since they not only keep people moving around, but also guarantee that machines and equipment work smoothly. The objective of this work is to tackle the blending problems using computer-aided tools for the initial stage of the product design. A systematic methodology for design......A tailor-made blended liquid product is defined as a formulation of various chemicals in the liquid state to obtain a liquid mixture with a specific set of desired characteristics and qualities. Examples of blended liquid products are synthetic fuels and lubricants. This type of products is very...... of tailor-made blended products has been developed, which has four main tasks. First, the design problem is defined: the product needs are identified, translated into target properties and the bounds for each target property are defined. Secondly, target property models are retrieved from a property model...

  7. Crowdsourcing New Product Design on the Web: An Analysis of Online Designer Platform Service

    Directory of Open Access Journals (Sweden)

    Xin Dai

    2013-01-01

    Full Text Available A designer is a core resource in the fashion industry. Successful designers need to be creative and quick to understand the business and wider environment in which they are operating. The Designer Platform Service (DPS, which combines the mechanism of crowdsourcing and group buying on the web, provides a platform for entrant designers to try their abilities in the real market practice. Freelance designers post design samples or sketches of products on the website of DPS, and consumers may preorder the products (each at a fixed price online based on the design information. Once the number of ordering reaches or passes a certain threshold, that is, the minimum production quantity (MPQ, DPS will arrange for production and delivery according to the orders received. This novel service boosts the growth of entrant designers and links designing works with real markets directly. We are interested in how the price and MPQ decisions are made in DPS, with consideration of the entrant designer's objective, decision sequences, and customer demand structures. We develop Stackelberg games to model and derive the equilibrium solutions under individual scenarios. Our findings suggest feasibility of the DPS business model.

  8. Designing Difference: Co-Production of Spaces of Potentiality

    Directory of Open Access Journals (Sweden)

    Garrett Wolf

    2016-03-01

    Full Text Available Design and Planning professionals have long been influenced by the belief in physically and spatially deterministic power over people and the environment, a belief that their representations of space become space. As a result the goal of design often becomes “fixing” or directing behavior and culture instead of letting culture happen. This outlook often prevents designers from engaging critically with culture, through representational space and spatial practice, as a crucial, possibly the most crucial, aspect in the design process. Just as human cultures interact to constantly reproduce and co-produce hybrid cultures, the professional designer and those users and experiencers of design (at whatever scale must interact to co-produce spaces and places of activity. Through a critique of the practice of placemaking, we highlight the need to differentiate between participation and co-production. Understanding participation as one element of the design process and the role of design at larger scales of co-productive processes can help designers have a better understanding of how spaces are produced, and the role of designers in the creation of spaces of potentiality. Agamben’s writing on potentialities and Lefebvre’s spatial triad offer a theoretical framework to investigate the ethical role of professional designers in society while taking a critical stance against the singular solutions of modernist urban transformation. Spaces of Potentiality are seen here as a designer’s simultaneous withdrawal from rational problem solving and deterministic solutions, and an engagement with open source strategies for the co-production of urban space.

  9. The computer-aided design of rubber-metal products

    Directory of Open Access Journals (Sweden)

    Pavlo S. Shvets

    2015-12-01

    Full Text Available The important problem in design of rubber-metal products is the optimization of their mass without sacrificing of proportionality factor is in the limits of standard. Aim: The aim of this work is to improve the computer-aided systems by development and implementation of improved optimization method in rubber-metal CAD systems for designers based on the reverse optimization. Materials and Methods: The paper studies the matters of computer-aided structural design of technical composite products composed of anisotropic materials that are essentially different in properties. Results: The structure of CAD systems for designers solving the problems of such design is offered and the work principles of its subsystems are described. It is shown that complicated systems optimization in CAD systems must consider as restrictions the entitative connection between separate elements of these systems within the area of the optimizing arguments. Conclusions: The problem of the “reverse” optimization when objective functions are the connectivity area parameters is considered. In many cases, this allows receiving solutions that are more effective during the computer-aided design process. The developed CAD system for designers was used during the production of rubber-metal shock absorbers at the Odessa Rubber Technical Articles Plant. The positive technical and economic effect was obtained.

  10. Applying fuel cell experience to sustainable power products

    Science.gov (United States)

    King, Joseph M.; O'Day, Michael J.

    Fuel cell power plants have demonstrated high efficiency, environmental friendliness, excellent transient response, and superior reliability and durability in spacecraft and stationary applications. Broader application of fuel cell technology promises significant contribution to sustainable global economic growth, but requires improvement to size, cost, fuel flexibility and operating flexibility. International Fuel Cells (IFC) is applying lessons learned from delivery of more than 425 fuel cell power plants and 3 million h of operation to the development of product technology which captures that promise. Key findings at the fuel cell power plant level include: (1) ancillary components account for more than 40% of the weight and nearly all unscheduled outages of hydrocarbon-fuelled power plants; a higher level of integration and simplification is required to achieve reasonable characteristics, (2) hydrocarbon fuel cell power plant components are highly interactive; the fuel processing approach and power plant operating pressure are major determinants of overall efficiency, and (3) achieving the durability required for heavy duty vehicles and stationary applications requires simultaneous satisfaction of electrochemical, materials and mechanical considerations in the design of the cell stack and other power plant components. Practical designs must minimize application specific equipment. Related lessons for stationary fuel cell power plants include: (1) within fuel specification limits, natural gas varies widely in heating value, minor constituents such as oxygen and nitrogen content and trace compounds such as the odorant; (2) city water quality varies widely; recovery of product water for process use avoids costly, complicated and site-specific water treatment systems, but water treatment is required to eliminate impurities and (3) the embedded protection functions for reliable operation of fuel cell power conditioners meet or exceed those required for connection to

  11. An Adaptive Design Methodology for Reduction of Product Development Risk

    CERN Document Server

    Pakala, Hara Gopal Mani; Kvsvn, Dr Raju; Khan, Dr Ibrahim; 10.5121/ijasuc.2011.2303

    2011-01-01

    Embedded systems interaction with environment inherently complicates understanding of requirements and their correct implementation. However, product uncertainty is highest during early stages of development. Design verification is an essential step in the development of any system, especially for Embedded System. This paper introduces a novel adaptive design methodology, which incorporates step-wise prototyping and verification. With each adaptive step product-realization level is enhanced while decreasing the level of product uncertainty, thereby reducing the overall costs. The back-bone of this frame-work is the development of Domain Specific Operational (DOP) Model and the associated Verification Instrumentation for Test and Evaluation, developed based on the DOP model. Together they generate functionally valid test-sequence for carrying out prototype evaluation. With the help of a case study 'Multimode Detection Subsystem' the application of this method is sketched. The design methodologies can be compar...

  12. Design and production of the KBS-3 repository

    Energy Technology Data Exchange (ETDEWEB)

    Moren, Lena

    2010-12-15

    The report contains the common basis for a set of Production reports, presenting how the KBS-3 repository is designed, produced and inspected. The set of reports is included in the safety report for the KBS-3 repository and repository facility. The report presents the role of the Production reports within the safety report and their common purposes and objectives. An important part of the report is to present the background and sources to the principles to be applied in the design, the functions of the KBS-3 repository and the barrier functions the engineered barriers and rock. Further, the methodology to substantiate detailed design premises for the engineered barriers, underground openings and other parts of the KBS-3 repository is presented. The report also gives an overview of the KBS-3 system and its facilities and the production lines for the spent fuel, the engineered barriers and underground openings. Finally, an introduction to quality management, safety classification and their application is given

  13. Systematic Computer-Aided Framework for Sustainable Chemical Product Design

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Kalakul, Sawitree

    -physical property needs and the process/application needs. Process/application and property needs are connected through an analysis of the property influence on the process/application models and thermodynamic relations. The sustainability is considered through product and process/application performance, economics......-designing demand increased sustainability and minimal trade-off with system performance. In the CAPD formulation, the product properties are related to the needs of heat pump cycle and its components through sensitivity analysis of the thermodynamic models and energy balances of the system. Furthermore, simple...... models are included for efficient assessment of the sustainability and design criteria of both the cycle and its components. It will be demonstrated that the working fluid product designed is optimal with respect to the sustainability and the heat pump cycle performance....

  14. A Systematic Methodology for Design of Emulsion Based Chemical Products

    DEFF Research Database (Denmark)

    Mattei, Michele; Kontogeorgis, Georgios; Gani, Rafiqul

    2012-01-01

    A systematic methodology for emulsion based chemical product design is presented. The methodology employs a model-based product synthesis/design stage and a modelexperiment based further refinement and/or validation stage. In this paper only the first stage is presented. The methodology employs...... a hierarchical approach starting with the identification of the needs to be satisfied by the emulsified product and then building up the formulation by adding one-by-one the different classes of chemicals. A structured database together with dedicated property prediction models and evaluation criteria...... are employed to obtain a list of formulations that satisfy constraints representing the desired needs (target properties). Through a conceptual case study dealing with the design of a sunscreen lotion, the application of this new methodology is illustrated....

  15. Designing Mechatronic Products - Achieving Integration by Means of Modelling Dependencies

    DEFF Research Database (Denmark)

    Torry-Smith, Jonas

    to the absence of a common modelling language. The further research is aimed at one particular challenge related to the integration phenomenon, which is the difficulty in modelling and controlling multiple relations in the product concept as a consequence of the multidisciplinary development. ‘A product......The research carried out in this PhD thesis focuses on the integration phenomenon in the design of mechatronic products. It contributes to the understanding of the phenomenon and to conceptual modelling of mechatronic products. These products are perceived to have emerged as a consequence...... disciplines have to be combined and function in an integrated fashion. The holistic view of the product concept is sometimes missing in projects and engineering disciplines are reluctant to interact. Investigations of literature, cases from industry and practical experience are used for dissecting...

  16. Risk Management and Loss Optimization at Design Process of Products

    Directory of Open Access Journals (Sweden)

    Katalin Németh-Erdődi

    2008-06-01

    Full Text Available We’d like to introduce a flexible system of design process elements to support theformation and tool selection of an efficient, „lean” product design process. To do this weidentify numerical risk factors and introduce a calculating method for optimising takinginto consideration- the effect of design steps on usage characteristics,- the time needed by the design elements and the resultant losses,- the effect of design on the success of the implementation process.A generic model was developed for harmonising and sequencing of market and technicalactivities with built-in acceptance phase. The steps of the model can be selected flexiblydepending on design goals. The model regards the concurrent character of market,technical and organising activities, the critical speed of information flow between them andthe control, decision and confirmation points.

  17. Nanostructured Semiconductor Device Design in Solar Cells

    Science.gov (United States)

    Dang, Hongmei

    We demonstrate the use of embedded CdS nanowires in improving spectral transmission loss and the low mechanical and electrical robustness of planar CdS window layer and thus enhancing the quantum efficiency and the reliability of the CdS-CdTe solar cells. CdS nanowire window layer enables light transmission gain at 300nm-550nm. A nearly ideal spectral response of quantum efficiency at a wide spectrum range provides an evidence for improving light transmission in the window layer and enhancing absorption and carrier generation in absorber. Nanowire CdS/CdTe solar cells with Cu/graphite/silver paste as back contacts, on SnO2/ITO-soda lime glass substrates, yield the highest efficiency of 12% in nanostructured CdS-CdTe solar cells. Reliability is improved by approximately 3 times over the cells with the traditional planar CdS counterpart. Junction transport mechanisms are delineated for advancing the basic understanding of device physics at the interface. Our results prove the efficacy of this nanowire approach for enhancing the quantum efficiency and the reliability in windowabsorber type solar cells (CdS-CdTe, CdS-CIGS and CdS-CZTSSe etc) and other optoelectronic devices. We further introduce MoO3-x as a transparent, low barrier back contact. We design nanowire CdS-CdTe solar cells on flexible foils of metals in a superstrate device structure, which makes low-cost roll-to-roll manufacturing process feasible and greatly reduces the complexity of fabrication. The MoO3 layer reduces the valence band offset relative to the CdTe, and creates improved cell performance. Annealing as-deposited MoO3 in N 2 reduces series resistance from 9.98 O/cm2 to 7.72 O/cm2, and hence efficiency of the nanowire solar cell is improved from 9.9% to 11%, which efficiency comparable to efficiency of planar counterparts. When the nanowire solar cell is illuminated from MoO 3-x /Au side, it yields an efficiency of 8.7%. This reduction in efficiency is attributed to decrease in Jsc from 25.5m

  18. Developmental engineering: a new paradigm for the design and manufacturing of cell-based products. Part II: from genes to networks: tissue engineering from the viewpoint of systems biology and network science.

    Science.gov (United States)

    Lenas, Petros; Moos, Malcolm; Luyten, Frank P

    2009-12-01

    The field of tissue engineering is moving toward a new concept of "in vitro biomimetics of in vivo tissue development." In Part I of this series, we proposed a theoretical framework integrating the concepts of developmental biology with those of process design to provide the rules for the design of biomimetic processes. We named this methodology "developmental engineering" to emphasize that it is not the tissue but the process of in vitro tissue development that has to be engineered. To formulate the process design rules in a rigorous way that will allow a computational design, we should refer to mathematical methods to model the biological process taking place in vitro. Tissue functions cannot be attributed to individual molecules but rather to complex interactions between the numerous components of a cell and interactions between cells in a tissue that form a network. For tissue engineering to advance to the level of a technologically driven discipline amenable to well-established principles of process engineering, a scientifically rigorous formulation is needed of the general design rules so that the behavior of networks of genes, proteins, or cells that govern the unfolding of developmental processes could be related to the design parameters. Now that sufficient experimental data exist to construct plausible mathematical models of many biological control circuits, explicit hypotheses can be evaluated using computational approaches to facilitate process design. Recent progress in systems biology has shown that the empirical concepts of developmental biology that we used in Part I to extract the rules of biomimetic process design can be expressed in rigorous mathematical terms. This allows the accurate characterization of manufacturing processes in tissue engineering as well as the properties of the artificial tissues themselves. In addition, network science has recently shown that the behavior of biological networks strongly depends on their topology and has

  19. The lean product design and development journey a practical view

    CERN Document Server

    Pessôa, Marcus Vinicius Pereira

    2017-01-01

    This book presents a series of high performance product design (PD) and development best practices that can create or improve product development organization. In contrast to other books that focus only on Toyota or other individual companies applying lean IPD, this book explains the lean philosophy more broadly and includes discussions of systems engineering, design for X (DFX), agile development, integrated product development, and project management. The “Lean Journey” proposed here takes a value-centric approach, where the lean principles are applied to PD to allow the tools and methods selected to emerge from observation of the individual characteristics of each enterprise. This means that understanding lean product development (LPD) is not about knowing which tools are available but knowing how to apply the philosophy. The book comes with an accompanying manual with problems and solutions available on Springer Extras.

  20. Sustainable Process Design of Biofuels: Bioethanol Production from Cassava rhizome

    DEFF Research Database (Denmark)

    Mangnimit, S.; Malakul, P.; Gani, Rafiqul

    2013-01-01

    This study is focused on the sustainable process design of bioethanol production from cassava rhizome. The study includes: process simulation, sustainability analysis, economic evaluation and life cycle assessment (LCA). A steady state process simulation if performed to generate a base case design...... of the bioethanol conversion process using cassava rhizome as a feedstock. The sustainability analysis is performed to analyze the relevant indicators in sustainability metrics, to definedesign/retrofit targets for process improvements. Economic analysis is performed to evaluate the profitability of the process........ Also, simultaneously with sustainability analysis, the life cycle impact on environment associated with bioethanol production is performed. Finally, candidate alternative designs are generated and compared with the base case design in terms of LCA, economics, waste, energy usage and enviromental impact...

  1. The design of Eco Board Games as an umbrella approach to sustainable product design education

    DEFF Research Database (Denmark)

    Boks, Casper; McAloone, Tim C.

    2009-01-01

    The multidisciplinarity and quickly broadening scope of sustainable product design education provide incentives for experimentation with different pedagogical techniques. One of these, involving the development of eco board games, has been used at both the Technical University Denmark...

  2. Verifying Architectural Design Rules of the Flight Software Product Line

    Science.gov (United States)

    Ganesan, Dharmalingam; Lindvall, Mikael; Ackermann, Chris; McComas, David; Bartholomew, Maureen

    2009-01-01

    This paper presents experiences of verifying architectural design rules of the NASA Core Flight Software (CFS) product line implementation. The goal of the verification is to check whether the implementation is consistent with the CFS architectural rules derived from the developer's guide. The results indicate that consistency checking helps a) identifying architecturally significant deviations that were eluded during code reviews, b) clarifying the design rules to the team, and c) assessing the overall implementation quality. Furthermore, it helps connecting business goals to architectural principles, and to the implementation. This paper is the first step in the definition of a method for analyzing and evaluating product line implementations from an architecture-centric perspective.

  3. Pharmaceutical product development: A quality by design approach.

    Science.gov (United States)

    Pramod, Kannissery; Tahir, M Abu; Charoo, Naseem A; Ansari, Shahid H; Ali, Javed

    2016-01-01

    The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United States Food and Drug Administration (USFDA) emphasized the principles and applications of QbD in pharmaceutical development in their guidance for the industry. QbD attributes are addressed in question-based review, developed by USFDA for chemistry, manufacturing, and controls section of abbreviated new drug applications. QbD principles, when implemented, lead to a successful product development, subsequent prompt regulatory approval, reduce exhaustive validation burden, and significantly reduce post-approval changes. The key elements of QbD viz., target product quality profile, critical quality attributes, risk assessments, design space, control strategy, product lifecycle management, and continual improvement are discussed to understand the performance of dosage forms within design space. Design of experiments, risk assessment tools, and process analytical technology are also discussed for their role in QbD. This review underlines the importance of QbD in inculcating science-based approach in pharmaceutical product development.

  4. Pharmaceutical product development: A quality by design approach

    Science.gov (United States)

    Pramod, Kannissery; Tahir, M. Abu; Charoo, Naseem A.; Ansari, Shahid H.; Ali, Javed

    2016-01-01

    The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United States Food and Drug Administration (USFDA) emphasized the principles and applications of QbD in pharmaceutical development in their guidance for the industry. QbD attributes are addressed in question-based review, developed by USFDA for chemistry, manufacturing, and controls section of abbreviated new drug applications. QbD principles, when implemented, lead to a successful product development, subsequent prompt regulatory approval, reduce exhaustive validation burden, and significantly reduce post-approval changes. The key elements of QbD viz., target product quality profile, critical quality attributes, risk assessments, design space, control strategy, product lifecycle management, and continual improvement are discussed to understand the performance of dosage forms within design space. Design of experiments, risk assessment tools, and process analytical technology are also discussed for their role in QbD. This review underlines the importance of QbD in inculcating science-based approach in pharmaceutical product development. PMID:27606256

  5. Designer cell signal processing circuits for biotechnology.

    Science.gov (United States)

    Bradley, Robert W; Wang, Baojun

    2015-12-25

    Microorganisms are able to respond effectively to diverse signals from their environment and internal metabolism owing to their inherent sophisticated information processing capacity. A central aim of synthetic biology is to control and reprogramme the signal processing pathways within living cells so as to realise repurposed, beneficial applications ranging from disease diagnosis and environmental sensing to chemical bioproduction. To date most examples of synthetic biological signal processing have been built based on digital information flow, though analogue computing is being developed to cope with more complex operations and larger sets of variables. Great progress has been made in expanding the categories of characterised biological components that can be used for cellular signal manipulation, thereby allowing synthetic biologists to more rationally programme increasingly complex behaviours into living cells. Here we present a current overview of the components and strategies that exist for designer cell signal processing and decision making, discuss how these have been implemented in prototype systems for therapeutic, environmental, and industrial biotechnological applications, and examine emerging challenges in this promising field.

  6. Design, production and initial state of the canister

    Energy Technology Data Exchange (ETDEWEB)

    Cederqvist, Lars; Johansson, Magnus; Leskinen, Nina; Ronneteg, Ulf

    2010-12-15

    The report is included in a set of Production reports, presenting how the KBS-3 repository is designed, produced and inspected. The set of reports is included in the safety report for the KBS-3 repository and repository facility.The report provides input on the initial state of the canisters to the assessment of the long-term safety, SR-Site. The initial state refers to the properties of the engineered barriers once they have been finally placed in the KBS-3 repository and will not be further handled within the repository facility. In addition, the report provides input to the operational safety report, SR-Operation, on how the canisters shall be handled and disposed. The report presents the design premises and reference design of the canister and verifies the conformity of the reference design to the design premises. The production methods and the ability to produce canisters according to the reference design are described. Finally, the initial state of the canisters and their conformity to the reference design and design premises are presented

  7. Computer-Aided Chemical Product Design Framework: Design of High Performance and Environmentally Friendly Refrigerants

    DEFF Research Database (Denmark)

    Cignitti, Stefano; Zhang, Lei; Gani, Rafiqul

    a driving force for the industry to continuously seek novel refrigerants as current refrigerants risk phasing out due to environmental regulations. This trend has been seen since the Kyoto Protocol in 1997 and recently from the EU regulations from 2014, which will restrict the use of some known refrigerants...... properties and needs should carefully be selected for a given heat pump cycle to ensure that an optimum refrigerant is found? How can cycle performance and environmental criteria be integrated at the product design stage and not in post-design analysis? Computer-aided product design methods enable...... the possibility of designing novel molecules, mixtures and blends, such as refrigerants through a systematic framework (Cignitti et al., 2015; Yunus et al., 2014). In this presentation a computer-aided framework is presented for chemical product design through mathematical optimization. Here, molecules, mixtures...

  8. Sustainable Chemical Processes and Products. New Design Methodology and Design Tools

    OpenAIRE

    Korevaar, G.

    2004-01-01

    The current chemical industry is not sustainable, which leads to the fact that innovation of chemical processes and products is too often hazardous for society in general and the environment in particular. It really is a challenge to implement sustainability considerations in the design activities of chemical engineers. Therefore, the main question of this thesis is: how can a trained chemical engineer develop a conceptual design of a chemical process or a chemical product in such a way that ...

  9. Production of soluble Neprilysin by endothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Kuruppu, Sanjaya, E-mail: Sanjaya.Kuruppu@monash.edu [Department of Biochemistry and Molecular Biology, Building 77, Monash University, Wellington Rd, Clayton, Vic 3800 (Australia); Rajapakse, Niwanthi W. [Department of Physiology, Building 13F, Monash University, Wellington Rd, Clayton, Vic 3800 (Australia); Minond, Dmitriy [Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port Saint Lucie, FL 34987 (United States); Smith, A. Ian [Department of Biochemistry and Molecular Biology, Building 77, Monash University, Wellington Rd, Clayton, Vic 3800 (Australia)

    2014-04-04

    Highlights: • A soluble full-length form of Neprilysin exists in media of endothelial cells. • Exosomal release is the key mechanism for the production of soluble Neprilysin. • Inhibition of ADAM-17 by specific inhibitors reduce Neprilysin release. • Exosome mediated release of Neprilysin is dependent on ADAM-17 activity. - Abstract: A non-membrane bound form of Neprilysin (NEP) with catalytic activity has the potential to cleave substrates throughout the circulation, thus leading to systemic effects of NEP. We used the endothelial cell line Ea.hy926 to identify the possible role of exosomes and A Disintegrin and Metalloprotease 17 (ADAM-17) in the production of non-membrane bound NEP. Using a bradykinin based quenched fluorescent substrate (40 μM) assay, we determined the activity of recombinant human NEP (rhNEP; 12 ng), and NEP in the media of endothelial cells (10% v/v; after 24 h incubation with cells) to be 9.35 ± 0.70 and 6.54 ± 0.41 μmols of substrate cleaved over 3 h, respectively. The presence of NEP in the media was also confirmed by Western blotting. At present there are no commercially available inhibitors specific for ADAM-17. We therefore synthesised two inhibitors TPI2155-14 and TPI2155-17, specific for ADAM-17 with IC{sub 50} values of 5.36 and 4.32 μM, respectively. Treatment of cells with TPI2155-14 (15 μM) and TPI2155-17 (4.3 μM) resulted in a significant decrease in NEP activity in media (62.37 ± 1.43 and 38.30 ± 4.70, respectively as a % of control; P < 0.0001), implicating a possible role for ADAM-17 in NEP release. However, centrifuging media (100,000g for 1 h at 4 °C) removed all NEP activity from the supernatant indicating the likely role of exosomes in the release of NEP. Our data therefore indicated for the first time that NEP is released from endothelial cells via exosomes, and that this process is dependent on ADAM-17.

  10. The production of sorbitol by permeabilized and immobilized cells of Z. mobilis in sucrose

    OpenAIRE

    Josiane Alessandra Vignoli; Maria Antonia Colabone Celligoi; Rui Sérgio Ferreira da Silva; Márcio de Barros

    2006-01-01

    The production of sorbitol by permeabilized and immobilized cells of Zymomonas mobilis in Luffa cylindrica was investigated in sucrose medium. A full 2³ factorial design was used to verify the influence of each factor and its interactions. The cell permeabilization showed a significant and negative effect upon the production of sorbitol, while the time of cultivation and the immobilization process were significant and positive. The results demonstrated that the cell immobilization and the tim...

  11. Electro-optic product design for manufacture: where next?

    Science.gov (United States)

    Barr, John R. M.; MacDonald, M.; Jeffery, G.; Troughton, M.

    2016-10-01

    Manufacturing of electro-optic products for military environments poses a large number of apparently intractable and mutually contradictory problems. The ability to successfully engage in this area presents an intellectual challenge of a high order. The Advanced Targeting Sector of Leonardo's Airborne and Space Systems Division, based in Edinburgh, has developed a successful range of electro-optic products and transitioned these into a volume, and high value, manufacturing environment. As products cycle through the design process, there has been strong feedback from users, suppliers, and most importantly from our manufacturing organization, that has driven evolution of our design practices. It is fair to say that recent pointer trackers and lasers bear little resemblance to those designed and built 10 years ago. Looking ahead, this process will only continue. There are interesting technologies that will drive improvements in manufacturability, reliability and usability of electro-optic products. Examples might include freeform optics, additive manufacture of metal components, and laser welding of optics to metals, to name but a few. These have uses across our product portfolio and, when sufficiently matured, will have a major impact on the product quality and reliability

  12. Design, production and initial state of the closure

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    The report is included in a set of Production reports, presenting how the KBS-3 repository is designed, produced and inspected. The production reports are included in the safety report for the KBS-3 repository and repository facility. The report provides input on the initial state of the closure and plugs in underground openings other than deposition tunnels for the assessment of the long-term safety, SR-Site. The initial state refers to the properties of the engineered barriers once they have been finally placed in the KBS-3 repository and will not be further handled within the repository facility. In addition, the report provides some input to the operational safety report, SR-Operation, on how the closure and plugs shall be handled and installed. The report presents the design premises and reference designs of the closure and plugs and verifies their conformity to the design premises. It also briefly deals with the production of the closure and plugs. Finally, the initial state of the closure and plugs and their conformity to the reference designs and design premises are presented

  13. 77 FR 74196 - Draft Guidance for Industry on Safety Considerations for Product Design To Minimize Medication...

    Science.gov (United States)

    2012-12-13

    ... Product Design To Minimize Medication Errors; Availability AGENCY: Food and Drug Administration, HHS... guidance for industry entitled ``Safety Considerations for Product Design to Minimize Medication Errors... using a systems approach to minimize medication errors relating to product design. The draft...

  14. Design and industrial production of frequency standards in the USSR

    Science.gov (United States)

    Demidov, Nikolai A.; Uljanov, Adolph A.

    1990-01-01

    Some aspects of research development and production of quantum frequency standards, carried out in QUARTZ Research and Production Association (RPA), Gorky, U.S.S.R., were investigated for the last 25 to 30 years. During this period a number of rubidium and hydrogen frequency standards, based on the active maser, were developed and put into production. The first industrial model of a passive hydrogen maser was designed in the last years. Besides frequency standards for a wide application range, RPA QUARTZ investigates metrological frequency standards--cesium standards with cavity length 1.9 m and hydrogen masers with a flexible storage bulb.

  15. Research on Design Optimization Strategy in Virtual Product Development

    Institute of Scientific and Technical Information of China (English)

    潘军; 韩帮军; 范秀敏; 马登哲

    2004-01-01

    Simulation and optimization are the key points of virtual product development (VPD). Traditional engineering simulation software and optimization methods are inadequate to analyze the optimization problems because of its computational inefficiency. A systematic design optimization strategy by using statistical methods and mathematical optimization technologies is proposed. This method extends the design of experiments (DOE) and the simulation metamodel technologies. Metamodels are built to in place of detailed simulation codes based on effectively DOE, and then be linked to optimization routines for fast analysis, or serve as a bridge for integrating simulation software across different domains. A design optimization of composite material structure is used to demonstrate the newly introduced methodology.

  16. Sustainable Product Design, Engineering and Management Education for Industrial Design Engineering

    NARCIS (Netherlands)

    Boks, C.; Diehl, J.C.; Wever, R.

    2006-01-01

    Developments in the field of sustainable product design are manifold, which means that education in this field is rapidly evolving as well. In this paper, the continuously evolving portfolio of courses offered at Delft University of Technology’s Industrial Design Engineering faculty is systematicall

  17. Effects of blood products on inflammatory response in endothelial cells in vitro.

    Directory of Open Access Journals (Sweden)

    Martin Urner

    Full Text Available BACKGROUND: Transfusing blood products may induce inflammatory reactions within the vascular compartment potentially leading to a systemic inflammatory response. Experiments were designed to assess the inflammatory potential of different blood products in an endothelial cell-based in vitro model and to compare baseline levels of potentially activating substances in transfusion products. METHODS: The inflammatory response from pre-activated (endotoxin-stimulated and non-activated endothelial cells as well as neutrophil endothelial transmigration in response to packed red blood cells (PRBC, platelet concentrates (PC and fresh frozen plasma (FFP was determined. Baseline inflammatory mediator and lipid concentrations in blood products were evaluated. RESULTS: Following incubation with all blood products, an increased inflammatory mediator release from endothelial cells was observed. Platelet concentrates, and to a lesser extent also FFP, caused the most pronounced response, which was accentuated in already pre-stimulated endothelial cells. Inflammatory response of endothelial cells as well as blood product-induced migration of neutrophils through the endothelium was in good agreement with the lipid content of the according blood product. CONCLUSION: Within the group of different blood transfusion products both PC and FFP have a high inflammatory potential with regard to activation of endothelial cells. Inflammation upon blood product exposure is strongly accentuated when endothelial cells are pre-injured. High lipid contents in the respective blood products goes along with an accentuated inflammatory reaction from endothelial cells.

  18. EXPERIMENTAL RESEARCH REGARDING LEATHER APPLICATIONS IN PRODUCT DESIGN

    Directory of Open Access Journals (Sweden)

    PRALEA Jeni

    2015-05-01

    Full Text Available This paper presents the role and importance of experimental research in design activity. The designer, as a researcher and a project manager, proposes to establish a relationship between functional-aesthetic-constructive-technological-economic,based on the aesthetic possibilities of the materials used for the experiments. With the aim to identify areas for the application of leather waste resulted from the production process, the paper presents experiments conducted with this material in combination with wood, by using different techniques that lead to different aesthetic effects. Identifying the areas to use and creating products from leather and/or wood waste, is based on the properties of these materials. Leather, the subject of these experiments, has the advantage that it can be used on both sides. Tactile differences of the two sides of this material has both aesthetical and functional advantages, which makes it suitable for applications on products that meet the requirements of "design for all". With differentiated tactile characteristics, in combination with other materials, for these experiments wood, easily "read touch" products can be generated to help people with certain disabilities. Thus, experiments presented in this paper allows the establishment of aesthetic schemes applicable to products that are friendly both with the environment (based on the reuse of wood and leather waste and with the users (can be used as applications, accessories and concepts of products for people with certain disabilities. The designer’s choices or decisions can be based on the results of this experiment. The experiment enables the designer to develop creative, innovative and environmentally friendly products.

  19. Materials selection and design of products with low environmental impact

    Energy Technology Data Exchange (ETDEWEB)

    Ashby, M.F. [Engineering Design Centre, Cambridge Univ. (United Kingdom). Dept. of Engineering, Engineering Design Centre; Wegst, U.G.K. [Max-Planck-Inst. fuer Metallforschung, Stuttgart (Germany)

    2002-06-01

    The creation, use and disposal of any engineering product carry with it an environmental burden. Materials contribute to it in their production, use and disposal of these products. The minimisation of the environmental burden for the whole life-time requires the selection of materials that-without compromising product quality-create less toxic by-products, allow a longer life, are more easily recycled, are lighter and less energy intensive, and that, where possible, use renewable or non-critical resources. The research described here aims at the environmentally-conscious selection of materials early in the design process. It is illustrated by a case study on materials substitution for lightweight cars. (orig.)

  20. Chemical Product Design: A new challenge of applied thermodynamics

    DEFF Research Database (Denmark)

    Abildskov, Jens; Kontogeorgis, Georgios

    2004-01-01

    of such a product involving both solid-liquid phases and (non-equilibrium) metastable states. Thus, many of these products are colloidal systems of different types, e.g. liquid-liquid emulsions, suspensions, powders, solid and liquid dispersions, aerosols and sprays. The physical chemistry (thermodynamics......, stability) of such products is often as important as their manufacture, while a number of non-traditional manufacturing/ separation processes are of relevance, e.g. emulsification, foaming, gelation, granulation and crystallization. Today, serious gaps exist in our thermodynamic modelling abilities when we...... try to describe and understand chemical products with traditional thermodynamic models, typically applicable to problems of petrochemical industries. The purpose of this article is two-fold: first to present some current and future challenges in thermodynamic modelling towards chemical product design...

  1. Recirculation: A New Concept to Drive Innovation in Sustainable Product Design for Bio-Based Products

    Directory of Open Access Journals (Sweden)

    James Sherwood

    2016-12-01

    Full Text Available Bio-based products are made from renewable materials, offering a promising basis for the production of sustainable chemicals, materials, and more complex articles. However, biomass is not a limitless resource or one without environmental and social impacts. Therefore, while it is important to use biomass and grow a bio-based economy, displacing the unsustainable petroleum basis of energy and chemical production, any resource must be used effectively to reduce waste. Standards have been developed to support the bio-based product market in order to achieve this aim. However, the design of bio-based products has not received the same level of attention. Reported here are the first steps towards the development of a framework of understanding which connects product design to resource efficiency. Research and development scientists and engineers are encouraged to think beyond simple functionality and associate value to the potential of materials in their primary use and beyond.

  2. Recirculation: A New Concept to Drive Innovation in Sustainable Product Design for Bio-Based Products.

    Science.gov (United States)

    Sherwood, James; Clark, James H; Farmer, Thomas J; Herrero-Davila, Lorenzo; Moity, Laurianne

    2016-12-29

    Bio-based products are made from renewable materials, offering a promising basis for the production of sustainable chemicals, materials, and more complex articles. However, biomass is not a limitless resource or one without environmental and social impacts. Therefore, while it is important to use biomass and grow a bio-based economy, displacing the unsustainable petroleum basis of energy and chemical production, any resource must be used effectively to reduce waste. Standards have been developed to support the bio-based product market in order to achieve this aim. However, the design of bio-based products has not received the same level of attention. Reported here are the first steps towards the development of a framework of understanding which connects product design to resource efficiency. Research and development scientists and engineers are encouraged to think beyond simple functionality and associate value to the potential of materials in their primary use and beyond.

  3. Concepts in production ecology for analysis and design of animal and plant-animal production systems

    NARCIS (Netherlands)

    Ven, van de G.W.J.; Ridder, de N.; Keulen, van H.; Ittersum, van M.K.

    2003-01-01

    The use of a hierarchy in growth factors (defining, limiting and reducing growth factors), as developed for plant production has shown its usefulness in the analysis and design of plant production systems. This hierarchy presents a theoretical framework for the analysis of biophysical conditions in

  4. Supplier integration for new product developments: antecedents for supplier integration in modular product designs

    NARCIS (Netherlands)

    Eggers, Justus Erich

    2016-01-01

    Original equipment manufacturers (OEMs) increasingly integrate supplier resources in new product developments (NPD) to overcome bottlenecks of resource and to create competitive advantages. At the same time, OEMs react to the new market challenges by implementing modular product designs. Despite the

  5. Knowledge productivity : designing and testing a method to diagnose knowledge productivity and plan for enhancement

    NARCIS (Netherlands)

    Stam, Christiaan David

    2007-01-01

    Our economy has changed from an industrial into a knowledge economy in which knowledge productivity has become the main challenge. The lack of appropriate techniques to reveal knowledge productivity hinders organizations to design effective policies aiming at improving knowledge-based performance. T

  6. Future user-product arrangements: combining product impact and scenarios in design for multi age success

    NARCIS (Netherlands)

    Dorrestijn, Steven; Voort, van der Mascha; Verbeek, Peter-Paul

    2014-01-01

    The presence of four generations in business and organisations and the prevalence of ever-evolving technology, pose questions for technology design; a much wider range of user-product arrangements needs to be forecast and designed for. To provide a theoretical framework that accommodates the need to

  7. 3D scan to product design: Methods, techniques, and cases

    NARCIS (Netherlands)

    Lee, W.; Lee, B.; Kim, S.; Jung, H.; Jeon, E.; Choi, T.; You, H.

    2015-01-01

    3D scanning technology has derived great opportunities for ergonomic product designs. This paper is aimed to introduce various research cases and methods based on 3D scanning have conducted by an ergonomics laboratory in South Korea. Sizing systems and representative 3D models developed on anthropom

  8. 77 FR 20281 - Designation of Product Categories for Federal Procurement

    Science.gov (United States)

    2012-04-04

    ... first FEDERAL REGISTER issue of each #0;week. #0; #0; #0; #0;#0;Federal Register / Vol. 77, No. 65... cleaners and protectors; inks; packaging and insulating materials; pneumatic equipment lubricants; and wood... procurement for which there may be overlap with an EPA-designated recovered content product. The first...

  9. Exploring the use of consumer collages in product design

    NARCIS (Netherlands)

    Costa, A.I.A.; Schoolmeester, D.; Dekker, M.; Jongen, W.M.F.

    2003-01-01

    This paper presents the development, application and evaluation of a method for need identification in food product design, which combines the use of collage techniques and focus groups. Recent findings in neurobiology and psychology have considerable relevance for methodological improvement in cons

  10. Multi-objective evolutionary optimisation for product design and manufacturing

    CERN Document Server

    2011-01-01

    Presents state-of-the-art research in the area of multi-objective evolutionary optimisation for integrated product design and manufacturing Provides a comprehensive review of the literature Gives in-depth descriptions of recently developed innovative and novel methodologies, algorithms and systems in the area of modelling, simulation and optimisation

  11. New insights into consumer-oriented food products design

    NARCIS (Netherlands)

    Almeida Costa, A.I.

    2003-01-01

      To test the implementation of the most promising methods and tools associated with the early phases of a consumer-oriented approach to food product design;To improve the tested methods, or develop new ones, whenever necessary;To use the results obtained to propose research guidelines leading to

    • Application of Absorption Modeling in Rational Design of Drug Product Under Quality-by-Design Paradigm.

      Science.gov (United States)

      Kesisoglou, Filippos; Mitra, Amitava

      2015-09-01

      Physiologically based absorption models can be an important tool in understanding product performance and hence implementation of Quality by Design (QbD) in drug product development. In this report, we show several case studies to demonstrate the potential application of absorption modeling in rational design of drug product under the QbD paradigm. The examples include application of absorption modeling—(1) prior to first-in-human studies to guide development of a formulation with minimal sensitivity to higher gastric pH and hence reduced interaction when co-administered with PPIs and/or H2RAs, (2) design of a controlled release formulation with optimal release rate to meet trough plasma concentrations and enable QD dosing, (3) understanding the impact of API particle size distribution on tablet bioavailability and guide formulation design in late-stage development, (4) assess impact of API phase change on product performance to guide specification setting, and (5) investigate the effect of dissolution rate changes on formulation bioperformance and enable appropriate specification setting. These case studies are meant to highlight the utility of physiologically based absorption modeling in gaining a thorough understanding of the product performance and the critical factors impacting performance to drive design of a robust drug product that would deliver the optimal benefit to the patients.

    • Conceiving product ideas in an initial and uncertain design situation

      DEFF Research Database (Denmark)

      Hansen, Claus Thorp; Andreasen, Mogens Myrup

      2006-01-01

      , which carry innovation. Traditional approaches to conceptualisation are no longer sufficient. Too many engineering designers have practiced or cultivated a one-sided product quality focus and too many believe that creativity can compensate for a lack of knowledge and insight into the users’ perception...... of quality and value. Too many engineering designers work stereotypically based on an understanding of the physical product as the core of ideation, and use the conception of a “problem” as the point of departure for the design process. The aim of this research work is to create a multisided, dynamic...... that our research work contains an new contribution to theory, and that we have established a strong justification for the ontology, but we have to emphasize that the ontology has not yet been applied by students or in industrial practice. A test and verification of the ontology still remains. Thus...

    • Mu2e production solenoid cryostat conceptual design

      Energy Technology Data Exchange (ETDEWEB)

      Nicol, T.H.; Kashikhin, V.V.; Page, T.M.; Peterson, T.J.; /Fermilab

      2011-06-01

      Mu2e is a muon-to-electron conversion experiment being designed by an international collaboration of more than 65 scientists and engineers from more than 20 research institutions for installation at Fermilab. The experiment is comprised of three large superconducting solenoid magnet systems, production solenoid (PS), transport solenoid (TS) and detector solenoid (DS). A 25 kW, 8 GeV proton beam strikes a target located in the PS creating muons from the decay of secondary particles. These muons are then focused in the PS and the resultant muon beam is transported through the TS towards the DS. The production solenoid presents a unique set of design challenges as the result of high radiation doses, stringent magnetic field requirements, and large structural forces. This paper describes the conceptual design of the PS cryostat and will include discussions of the vacuum vessel, thermal shield, multi-layer insulation, cooling system, cryogenic piping, and suspension system.

    • Fuel lignocellulosic briquettes, die design and products study

      Energy Technology Data Exchange (ETDEWEB)

      Granada, E.; Miguez, J.L.; Moran, J. [Vigo Univ. (Spain). E.T.S. Ingenieros Industriales y Minas; Lopez Gonzalez, L.M. [Universidad de La Rioja (Spain). Departamento de Ingenieria Mecanica

      2002-12-01

      Briquetting of biomass can be done through various techniques. The present work describes the process of designing a taper die and its optimisation for use in a hydraulic machine. The application of an experimental design technique, and the later statistical analysis of the results is presented, applied to a laboratory hydraulic press densification process of lignocellulosic biomass. The most appropriate experiment type is determined for a first set of experiments; calculating, among other things: minimum number of tests to carry out to obtain binding conclusions, most influential factors, and search paths to improve fuel quality. Another experiment type is determined for a second set of experiments, taking account of the most influential factors (pressure, temperature and moisture content), and also the number of tests to carry out considering the improvement of density and friability. Finally, an approximation study of the best product allows conclusions to be reached on product behaviour beyond the experimental design range factors. (Author)

    • Evaluation of critical materials in five additional advance design photovoltaic cells

      Energy Technology Data Exchange (ETDEWEB)

      Smith, S.A.; Watts, R.L.; Martin, P.; Gurwell, W.E.

      1981-02-01

      The objective of this study is to identify potential material supply constraints due to the large-scale deployment of five advanced photovoltaic (PV) cell designs, and to suggest strategies to reduce the impacts of these production capacity limitations and potential future material shortages. The Critical Materials Assessment Program (CMAP) screens the designs and their supply chains and identifies potential shortages which might preclude large-scale use of the technologies. The results of the screening of five advanced PV cell designs are presented: (1) indium phosphide/cadmium sulfide, (2) zinc phosphide, (3) cadmium telluride/cadmium sulfide, (4) copper indium selenium, and (5) cadmium selenide photoelectrochemical. Each of these five cells is screened individually assuming that they first come online in 1991, and that 25 Gwe of peak capacity is online by the year 2000. A second computer screening assumes that each cell first comes online in 1991 and that each cell has a 5 GWe of peak capacity by the year 2000, so that the total online capacity for the five cells is 25 GWe. Based on a review of the preliminary baseline screening results, suggestions were made for varying such parameters as the layer thickness, cell production processes, etc. The resulting PV cell characterizations were then screened again by the CMAP computer code. The CMAP methodology used to identify critical materials is described; and detailed characterizations of the advanced photovoltaic cell designs under investigation, descriptions of additional cell production processes, and the results are presented. (WHK)

    • Design for Sustainability: Current Trends in Sustainable Product Design and Development

      Directory of Open Access Journals (Sweden)

      Marcel Crul

      2009-08-01

      Full Text Available The Design for Sustainability (D4S concept outlines methodologies for making sustainable improvements (social, economic and environmental to products by applying elements of life cycle thinking. D4S builds on the work of ecodesign to include economic and social concerns, and its methodology includes both incremental and radical innovation. The United Nations Environment Programme and the Delft University of Technology, the Netherlands, in concert with key partners, work to support, illustrate, and diffuse targeted D4S demonstration efforts, including the European Commission-funded Cleaner Production for Better Products project in Vietnam, that are needed to change unsustainable consumption and production patterns.

    • PRACTICE OF GESTALT THEORY IN INDUSTRIAL PRODUCT DESIGN

      Directory of Open Access Journals (Sweden)

      Erkut ERYAYAR

      2011-08-01

      Full Text Available It is common knowledge that Gestalt Theory argues that an organized whole represents more than the sum of its parts. According to this theory, which emerged in studies on visual perception, a whole is made up of many parts each of which cannot reflect the whole on its own. Likewise, an industrial design comprises various parts which create a meaningful and functional whole. The success of a design can be measured against its ability to be perceived the same way as it is designed. In this respect, the inclusion of Gestalt theory principles in the process of design will enable the end product to differ from others and its user to perceive it in the right direction.

    • USE OF LEAN PRODUCTION INSTRUMENTS IN DESIGNING THE EDUCATIONAL PROCESS

      Directory of Open Access Journals (Sweden)

      Elietta P. Burnasheva

      2016-03-01

      Full Text Available Introduction: the concept of lean production seeks not a reduction of costs but complete elimination of losses that do not bring added value to the product or service. In any system, in all processes – from production and assembly, to hospitality, education, health, transport and social services – there are hidden losses. Teaching itself is a kind of production process in which a certain “product” (student acquires the added value (knowledge and skills, that is why it has become topical in educational institution to establish the working group on introduction of lean production into the learning process. The article presents the factors that are to be taken into account while designing the educational process based on the lean production principles. Materials and Methods: methods of analysis of existing system of vocational training in higher school, monitoring of the results of educational practice, modeling and experimental work in the process of analytical work were used. Results: important direction for eliminating losses in the educational process is the development of the interlinked curricula, allowing to avoid repeated study of a number of didactic units in the organization of continuous training in the system “Vocational education – Higher education”. In order to eliminate the possibility of incompetent graduate one should focus on the organisation of objective final control. Losses in education are caused by to the mismatch between labour market demand and the spectrum of areas of training in educational institutions. Discussion and Conclusions: the lean production possibilities are defined as instrumental in ensuring the organisation of “the process of lean learning”: by applying some lean production instruments such as the designing of the educational process, preventing of “faulty work” while training students, the attuning of the training system to employers’ requests, the visualisation of the education

    • Systems metabolic engineering design: fatty acid production as an emerging case study.

      Science.gov (United States)

      Tee, Ting Wei; Chowdhury, Anupam; Maranas, Costas D; Shanks, Jacqueline V

      2014-05-01

      Increasing demand for petroleum has stimulated industry to develop sustainable production of chemicals and biofuels using microbial cell factories. Fatty acids of chain lengths from C6 to C16 are propitious intermediates for the catalytic synthesis of industrial chemicals and diesel-like biofuels. The abundance of genetic information available for Escherichia coli and specifically, fatty acid metabolism in E. coli, supports this bacterium as a promising host for engineering a biocatalyst for the microbial production of fatty acids. Recent successes rooted in different features of systems metabolic engineering in the strain design of high-yielding medium chain fatty acid producing E. coli strains provide an emerging case study of design methods for effective strain design. Classical metabolic engineering and synthetic biology approaches enabled different and distinct design paths towards a high-yielding strain. Here we highlight a rational strain design process in systems biology, an integrated computational and experimental approach for carboxylic acid production, as an alternative method. Additional challenges inherent in achieving an optimal strain for commercialization of medium chain-length fatty acids will likely require a collection of strategies from systems metabolic engineering. Not only will the continued advancement in systems metabolic engineering result in these highly productive strains more quickly, this knowledge will extend more rapidly the carboxylic acid platform to the microbial production of carboxylic acids with alternate chain-lengths and functionalities.

  1. Spatial augmented reality for product appearance design evaluation

    Directory of Open Access Journals (Sweden)

    Min Ki Park

    2015-01-01

    Full Text Available Augmented reality based on projection, called “Spatial Augmented Reality (SAR”, is a new technology that can produce immersive contents by overlapping virtuality and real-world environment. It has been paid attention as the next generation digital contents in media art and human–computer interaction (HCI. In this paper, we present a new methodology to evaluate the product appearance design more intuitively by means of SAR technique. The proposed method first projects the high-quality rendered image considering the optical property of materials onto the mock-up of a product. We also conduct a projector-camera calibration to compensate a color distortion according to a projector, a projection surface and environment lighting. The design evaluation methodology we propose offers more flexible and intuitive evaluation environment to a designer and user (evaluator than previous methods that are performed via a digital display. At the end of this research, we have conducted a case study for designing and evaluating appearance design of an automobile.

  2. Costs Models in Design and Manufacturing of Sand Casting Products

    CERN Document Server

    Perry, Nicolas; Bernard, Alain

    2010-01-01

    In the early phases of the product life cycle, the costs controls became a major decision tool in the competitiveness of the companies due to the world competition. After defining the problems related to this control difficulties, we will present an approach using a concept of cost entity related to the design and realization activities of the product. We will try to apply this approach to the fields of the sand casting foundry. This work will highlight the enterprise modelling difficulties (limits of a global cost modelling) and some specifics limitations of the tool used for this development. Finally we will discuss on the limits of a generic approach.

  3. A product-service system approach to telehealth application design.

    Science.gov (United States)

    Flores-Vaquero, Paul; Tiwari, Ashutosh; Alcock, Jeffrey; Hutabarat, Windo; Turner, Chris

    2016-06-01

    A considerable proportion of current point-of-care devices do not offer a wide enough set of capabilities if they are to function in any telehealth system. There is a need for intermediate devices that lie between healthcare devices and service networks. The development of an application is suggested that allows for a smartphone to take the role of an intermediate device. This research seeks to identify the telehealth service requirements for long-term condition management using a product-service system approach. The use of product-service system has proven to be a suitable methodology for the design and development of telehealth smartphone applications.

  4. Production Process for Stem Cell Based Therapeutic Implants: Expansion of the Production Cell Line and Cultivation of Encapsulated Cells

    Science.gov (United States)

    Weber, C.; Pohl, S.; Poertner, R.; Pino-Grace, Pablo; Freimark, D.; Wallrapp, C.; Geigle, P.; Czermak, P.

    Cell based therapy promises the treatment of many diseases like diabetes mellitus, Parkinson disease or stroke. Microencapsulation of the cells protects them against host-vs-graft reactions and thus enables the usage of allogenic cell lines for the manufacturing of cell therapeutic implants. The production process of such implants consists mainly of the three steps expansion of the cells, encapsulation of the cells, and cultivation of the encapsulated cells in order to increase their vitality and thus quality. This chapter deals with the development of fixed-bed bioreactor-based cultivation procedures used in the first and third step of production. The bioreactor system for the expansion of the stem cell line (hMSC-TERT) is based on non-porous glass spheres, which support cell growth and harvesting with high yield and vitality. The cultivation process for the spherical cell based implants leads to an increase of vitality and additionally enables the application of a medium-based differentiation protocol.

  5. Media fill for validation of a good manufacturing practice-compliant cell production process.

    Science.gov (United States)

    Serra, Marta; Roseti, Livia; Bassi, Alessandra

    2015-01-01

    According to the European Regulation EC 1394/2007, the clinical use of Advanced Therapy Medicinal Products, such as Human Bone Marrow Mesenchymal Stem Cells expanded for the regeneration of bone tissue or Chondrocytes for Autologous Implantation, requires the development of a process in compliance with the Good Manufacturing Practices. The Media Fill test, consisting of a simulation of the expansion process by using a microbial growth medium instead of the cells, is considered one of the most effective ways to validate a cell production process. Such simulation, in fact, allows to identify any weakness in production that can lead to microbiological contamination of the final cell product as well as qualifying operators. Here, we report the critical aspects concerning the design of a Media Fill test to be used as a tool for the further validation of the sterility of a cell-based Good Manufacturing Practice-compliant production process.

  6. Charge yield potential of indoor-operated solar cells incorporated into Product Integrated Photovoltaic (PIPV)

    Energy Technology Data Exchange (ETDEWEB)

    Reich, N.H.; van Sark, W.G.J.H.M.; Turkenburg, W.C. [Department of Science, Technology and Society, Copernicus Institute for Sustainable Development and Innovation, Utrecht University, Heidelberglaan 2, 3584 CS Utrecht (Netherlands)

    2011-02-15

    Solar cell performance parameters (open circuit voltage, short circuit current, fill factor and efficiency) are derived for different solar cell types for the irradiance range 0.1-1000 W/m{sup 2}. Also it is demonstrated how spectral mismatch factors for indoor lighting conditions are calculated. The presented methods and particular results may aid product designers in selecting appropriate solar cells for Product Integrated PV (PIPV) operated indoors and allow for more certainty in energy balance estimations of PIPV design concepts. (author)

  7. An Integrated Methodology for Emulsified Formulated Product Design

    DEFF Research Database (Denmark)

    Mattei, Michele

    significantly reduce both time and cost connected to product development by doing only the necessary experi- ments , and ensuring chances for innovation . The main contribution of this project i s the development of an integrated methodology for the design of emulsified formulated products. The methodology...... consists of three stages: the problem definition stage, the model - based design stage, and the experiment - based verification stage. In the probl em definition stage, the consumer needs are trans- lated into a set of target thermo - physical properties and into a list of categories of ingre- dients...... formulation are measured by means of tailor - made exp eriments. The formulation is then validated or, if necessary, re- fined thanks to a systematic list of action. The problem definition stage relies on a robust knowledge base, which needs to system- atically generate quantitative, useful input information...

  8. Property Modelling and Databases in Product-Process Design

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Sansonetti, Sascha

    , only the GC-model is used with the option to estimate missing group-contribution parameters through the CI-model. In this way, the application range of the GC-model is increased without the need for additional experimental data. This procedure for model development and use has been successfully......, they are not always available. Also, it may be too expensive or it may take too long to measure the required data. In these situations and when repetitive calculations are involved, as in process simulation, it is useful to have appropriate models to reliably predict the needed properties. For property model......Properties of pure chemicals and their mixtures play an important role in the design of chemicals based products and the processes that manufacture them. Although, the use of experimental data in the design and/or analysis of these chemicals based products and their processes is desirable...

  9. FUZZY OPTIMIZATION MODEL OF MAINTENANCE DESIGN FOR PRODUCT LEVEL REUSE

    Institute of Scientific and Technical Information of China (English)

    Feng Zhen; Xu Guohua

    2004-01-01

    Most used products must be maintained before they are reused.The modeling method for maintenance design of product level reuse based on quality function deployment is presented.A fuzzy linear optimization model is developed under financial uncertainty.Objective of the model is to maximize improvement rate of customer satisfaction level.Maintenance cost constrain is fuzzy.The algorithm for solution to the model is given.Its optimized results not only give attention to satisfaction degree of cost constraint,but also maximize objective value.An illustrative example involved water bump reuse is studied and the results show that the proposed model can effectively help maintenance planner determine the better design scheme.

  10. Ergonomics capability in product design and development: an organizational analysis.

    Science.gov (United States)

    Slappendel, C

    1994-10-01

    This paper suggests that the emergence and development of ergonomics capability in product design and development can be understood as a dynamic process of innovation, which is shaped by a combination of forces both internal and external to an organization. The comparative case study method was used to focus on six organizations (three pairs) operating from a manufacturing base in New Zealand. Data were collected from in-depth interviews, documents, archival sources and through observation. A framework for understanding the emergence and development of ergonomics capability in product design and development is presented. While ergonomics capability is a core concept in the model, four other major elements are identified. These are staffing routines, top management orientation, organizational configuration, and the external environment.

  11. Integrated Product and Process Design Using a Reverse Engineering System

    Institute of Scientific and Technical Information of China (English)

    A; Ajmal; T; S; Tat

    2002-01-01

    Computer-integrated manufacturing (CIM) and revers e engineering (RE) have changed drastically the concept of product re-design, pla nning and manufacture of components. However, the main problems currently facing the developers of reverse engineering system, is the time consuming digitis ation of 3D data and the conversion of large amounts of data into a concise and manageable format and linking it to a CAD/CAM system. Automated 3-D profile gen eration, measurements and inspection of manufactured comp...

  12. Pharmaceutical product development: A quality by design approach

    OpenAIRE

    Pramod, Kannissery; Tahir, M. Abu; Charoo, Naseem A.; Shahid H. Ansari; Ali, Javed

    2016-01-01

    The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United States Food and Drug Administration (USFDA) emphasized the principles and applications of QbD in pharmaceutical development in their guidance for the industry. QbD attributes are addressed in question-based review, developed by USFDA for chemistry, manufacturing, and controls s...

  13. Batteries and fuel cells: Design, employment, chemistry

    Science.gov (United States)

    Euler, K.-J.

    The history of electrochemical current sources is considered along with primary cells, standard cells, high-energy primary cells, high-energy storage batteries, and fuel cells. Aspects of battery research and development are also discussed, taking into account general considerations related to technological development projects, the introduction of mathematical methods into battery research, resistance measurements, autoradiography and other radiochemical methods, color photography as an aid in research, electron microscopy, X-ray and electron diffraction, spin resonance methods, and electrical measurements involving powders. Attention is given to zinc/manganese dioxide cells, zinc/mercury cells, zinc/silver oxide primary cells, cells utilizing atmospheric oxygen, lead-acid batteries, nickel-iron and nickel-cadmium storage batteries, zinc/silver storage batteries, dry cells with organic depolarizers, dry cells with solid electrolyte, and storage batteries utilizing hydrogen.

  14. Accounting for the waterless period of oil production in calculations on oil field production design

    Energy Technology Data Exchange (ETDEWEB)

    Aminov, M.F.; Butorin, O.I.

    1981-01-01

    Formulae on the dynamics of oil and liquid from a methodology developed by the Tatar Scientific-Research and Design Institute for the Oil Industry are adjusted, accounting for the waterless period in oil production. It is demonstrated that the process of accounting for the waterless period in oil production leads to a more accurate prediction of the engineering parameters for mining and oil field.

  15. Sustainable and Intensified Design of a Biodiesel Production Process

    DEFF Research Database (Denmark)

    Mansouri, Seyed Soheil; Ismail, Muhammad I.; Babi, Deenesh Kavi

    impact and maximum profitability is needed. In this work a computer-aided framework for process synthesis and process intensification is applied for sustainable production of biodiesel from pure/waste palm oil as the feedstock. This approach examines several biodiesel processing routes that were...... collected through available data and current technologies reported in the literature. Using this information, a generic superstructure of processing routes was created that described a network of configurations representing multiple designs for the production of biodiesel. Therefore, based on the currently...... of economic and environmental sustainability was identified. For the case of biodiesel production, the intensified process alternative turned out to be the most economical and more sustainable than other alternatives. The computer-aided methods and tools used in this work are: SustainPro (method and tool...

  16. Bioreactor design for continuous dark fermentative hydrogen production.

    Science.gov (United States)

    Jung, Kyung-Won; Kim, Dong-Hoon; Kim, Sang-Hyoun; Shin, Hang-Sik

    2011-09-01

    Dark fermentative H2 production (DFHP) has received increasing attention in recent years due to its high H2 production rate (HPR) as well as the versatility of the substrates used in the process. For most studies in this field, batch reactors have been applied due to their simple operation and efficient control; however, continuous DFHP operation is necessary from economical and practical points of view. Continuous systems can be classified into two categories, suspended and immobilized bioreactors, according to the life forms of H2 producing bacteria (HPB) used in the reactor. This paper reviews operational parameters for bioreactor design including pH, temperature, hydraulic retention time (HRT), and H2 partial pressure. Also, in this review, various bioreactor configurations and performance parameters including H2 yield (HY), HPR, and specific H2 production rate (SHPR) are evaluated and presented.

  17. Consumer Product Innovation and Sustainable Design: The evolution and impacts of successful products

    OpenAIRE

    2015-01-01

    The book builds on many years of research and teaching design and innovation at the Open University and was inspired by my archive of the (UK) Consumers’ Association publication, Which? This magazine, and the more recent Which? website, provide a unique written and visual record of the technological and design evolution of consumer products marketed in Britain from 1957 to the present.\\ud The core of the book comprises case studies of six classes of mechanical, electro-mechanical, electrical ...

  18. Metabolic Design and Control for Production in Prokaryotes

    Energy Technology Data Exchange (ETDEWEB)

    Chhabra, Swapnil R.; Keasling, J.D.

    2010-11-10

    Prokaryotic life on earth is manifested by its diversity and omnipresence. These microbes serve as natural sources of a large variety of compounds with the potential to serve the ever growing, medicinal, chemical and transportation needs of the human population. However, commercially viable production of these compounds can be realized only through significant improvement of the native production capacity of natural isolates. The most favorable way to achieve this goal is through the genetic manipulation of metabolic pathways that direct the production of these molecules. While random mutagenesis and screening have dominated the industrial production of such compounds in the past our increased understanding of microbial physiology over the last five decades has shifted this trend towards rational approaches for metabolic design. Major drivers of this trend include recombinant DNA technology, high throughput characterization of macromolecular cellular components, quantitative modeling for metabolic engine ring, targeted combinatorial engineering and synthetic biology. In this chapter we track the evolution of microbial engineering technologies from the black box era of random mutagenesis to the science and engineering-driven era of metabolic design.

  19. Integrated design strategy for product life-cycle management

    Science.gov (United States)

    Johnson, G. Patrick

    2001-02-01

    Two major trends suggest new considerations for environmentally conscious manufacturing (ECM) -- the continuation of dematerialization and the growing trend toward goods becoming services. A diversity of existing research could be integrated around those trends in ways that can enhance ECM. Major research-based achievements in information, computation, and communications systems, sophisticated and inexpensive sensing capabilities, highly automated and precise manufacturing technologies, and new materials continue to drive the phenomenon of dematerialization - the reduction of the material and energy content of per capita GDP. Knowledge is also growing about the sociology, economics, mathematics, management and organization of complex socio-economic systems. And that has driven a trend towards goods evolving into services. But even with these significant trends, the value of material, energy, information and human resources incorporated into the manufacture, use and disposal of modern products and services often far exceeds the benefits realized. Multi-disciplinary research integrating these drivers with advances in ECM concepts could be the basis for a new strategy of production. It is argued that a strategy of integrating information resources with physical and human resources over product life cycles, together with considering products as streams of service over time, could lead to significant economic payoff. That strategy leads to an overall design concept to minimize costs of all resources over the product life cycle to more fully capture benefits of all resources incorporated into modern products. It is possible by including life cycle monitoring, periodic component replacement, re-manufacture, salvage and human factor skill enhancement into initial design.

  20. Design and fabrication of silver-hydrogen cells

    Science.gov (United States)

    Klein, M. G.

    1975-01-01

    The design and fabrication of silver-hydrogen secondary cells capable of delivering higher energy densities than comparable nickel-cadmium and nickel-hydrogen cells and relatively high cycle life is presented. An experimental task utilizing single electrode pairs for the optimization of the individual electrode components, the preparation of a design for lightweight 20Ahr cells, and the fabrication of four 20Ahr cells in heavy wall test housing containing electrode stacks of the lightweight design are described. The design approach is based on the use of a single cylindrical self-contained cell with a stacked disc sequence of electrodes. The electrode stack design is based on the use of NASA- Astropower Separator Material, PPF fuel cell anodes, an intercell electrolyte reservoir concept and sintered silver electrodes. Results of performance tests are given.

  1. Recombinant Protein Production and Insect Cell Culture and Process

    Science.gov (United States)

    Spaulding, Glenn F. (Inventor); Goodwin, Thomas J. (Inventor); OConnor, Kim C. (Inventor); Francis, Karen M. (Inventor); Andrews, Angela D. (Inventor); Prewett, Tracey L. (Inventor)

    1997-01-01

    A process has been developed for recombinant production of selected polypeptides using transformed insect cells cultured in a horizontally rotating culture vessel modulated to create low shear conditions. A metabolically transformed insect cell line is produced using the culture procedure regardless of genetic transformation. The recombinant polypeptide can be produced by an alternative process using virtually infected or stably transformed insect cells containing a gene encoding the described polypeptide. The insect cells can also be a host for viral production.

  2. Small Cell Layouts Based on Accounting Product Demand and Operating Sequences

    Institute of Scientific and Technical Information of China (English)

    常剑峰; 钟约先; 韩赞东

    2004-01-01

    Most current cell layout methods do not take into account the product demand and operating sequences, and may be too sophisticated for facilities with a relatively small number of products. A specific method for designing small manufacturing cells was developed especially for the press production lines, which is computationally simple, and yet considers product demand and the operating sequences. A simulated application illustrates the robustness of the layouts to demand changes. The method uses simple rules and database tools, so it is accessible to a wide range of facilities.

  3. PEM Fuel Cells Redesign Using Biomimetic and TRIZ Design Methodologies

    Science.gov (United States)

    Fung, Keith Kin Kei

    Two formal design methodologies, biomimetic design and the Theory of Inventive Problem Solving, TRIZ, were applied to the redesign of a Proton Exchange Membrane (PEM) fuel cell. Proof of concept prototyping was performed on two of the concepts for water management. The liquid water collection with strategically placed wicks concept demonstrated the potential benefits for a fuel cell. Conversely, the periodic flow direction reversal concepts might cause a potential reduction water removal from a fuel cell. The causes of this water removal reduction remain unclear. In additional, three of the concepts generated with biomimetic design were further studied and demonstrated to stimulate more creative ideas in the thermal and water management of fuel cells. The biomimetic design and the TRIZ methodologies were successfully applied to fuel cells and provided different perspectives to the redesign of fuel cells. The methodologies should continue to be used to improve fuel cells.

  4. Sustainable Chemical Processes and Products. New Design Methodology and Design Tools

    NARCIS (Netherlands)

    Korevaar, G.

    2004-01-01

    The current chemical industry is not sustainable, which leads to the fact that innovation of chemical processes and products is too often hazardous for society in general and the environment in particular. It really is a challenge to implement sustainability considerations in the design activities o

  5. Design for Sustainability: Current Trends in Sustainable Product Design and Development

    NARCIS (Netherlands)

    Clark, G.; Kosoris, J.; Nguyen Hong, L.; Crul, M.

    2009-01-01

    The Design for Sustainability (D4S) concept outlines methodologies for making sustainable improvements (social, economic and environmental) to products by applying elements of life cycle thinking. D4S builds on the work of ecodesign to include economic and social concerns, and its methodology includ

  6. Metaphors we design by: The use of metaphors in product design

    NARCIS (Netherlands)

    Cila, N.

    2013-01-01

    Imagine a coffee maker that subtly references the serving gesture of a butler or a car that explicitly mimics the sleek and streamlined form of a jet plane. Such metaphors are frequently used by designers as a means to render the values and meanings they want to assign to a product into a physical f

  7. Lymphoid Cell-Glioma Cell Interaction Enhances Cell Coat Production by Human Gliomas: Novel Suppressor Mechanism

    Science.gov (United States)

    Dick, Steven J.; Macchi, Beatrice; Papazoglou, Savvas; Oldfield, Edward H.; Kornblith, Paul L.; Smith, Barry H.; Gately, Maurice K.

    1983-05-01

    Certain human glioma lines produce mucopolysaccharide coats that impair the generation of cytolytic lymphocytes in response to these lines in vitro. Coat production is substantially enhanced by the interaction of glioma cells with a macromolecular factor released by human peripheral blood mononuclear cells in culture. This interaction thus constitutes an unusual mechanism by which inflammatory cells may nonspecifically suppress the cellular immune response to at least one class of solid tumors in humans.

  8. Preliminary Design Report for the Yakima/Klickitat Production Project.

    Energy Technology Data Exchange (ETDEWEB)

    US Bonneville Power Administration

    1990-04-01

    A master plan for the Yakima/Klickitat Production Project (YKPP) was developed by the Northwest Power Planning Council (Council) on October 15, 1987, as a reasonable basis upon which the Bonneville Power Administration (BPA) could proceed to fund predesign work on the project. The Council approved the predesign work on the condition that eight preliminary tasks were completed. These tasks are: Task 1. Agreement on a refined statement of project goals. Task 2. Completion of a technical analysis of water supplies. Task 3. Completion of an experimental design plan. Task 4. Development of a harvest management plan. Task 5. Assessment of potential genetic risks. Task 6. Project coordination with all other affected parties. Task 7. Submission of a preliminary design report to the Council. Task 8. Develop a project management structure. The preliminary design report summarizes the work completed on these tasks. It provides a description of the preliminary design, engineering, and construction phases of project development, and gives an estimate of project costs. Also included is a description of other studies that were conducted to support YKPP planning. The results of studies conducted during the last 30 months indicate that hatchery facilities can be built in the Yakima and Klickitat subbasins to provide harvest benefits and to supplement natural production. Planning for the Yakima subbasin is at a more advanced stage of development than for the Klickitat subbasin because of greater availability of basic resource information. The information needed to proceed with final design and construction for the Klickitat subbasin will be available by 1992, as ongoing predesign work continues. This schedule is consistent with the anticipated phased completion of the YKPP by 1997.

  9. Optimization of Extracellular Lipase Production by Penicillium chrysogenum Using Factorial Design

    Directory of Open Access Journals (Sweden)

    Shafei, M. S.

    2011-01-01

    Full Text Available The effect of oxygen on lipase production by Penicillium chrysogenum was studied under two operating modes, controlled aeration rate tested and controlled agitation at dissolved oxygen concentration (DO 1.00 vvm. Lipase production and cell dry weight were tested in a stirred batch fermenter 5 L. Improvement in oxygen transfer rate (OTR either by aeration or agitation resulted in an increase in lipase production. Growth curves and lipase activities of P.chrysogenum were examined at agitation rates (200,400,600 rpm, aeration rates (2,4 vvm at different fermentation periods (24,48,72,96,120 h. Response Surface Methodology (RSM using Design Expert software was used to study the effect of aeration, agitation, and fermentation time on lipase activity and cell dry weight. These factors were analyzed using 21. 32 level factorial design. An optimal set of conditions that maximize lipase production: (2 vvm aeration; 600 rpm agitation after 72 h was obtained. The maximum lipase activity obtained was 240 U/mL. Beside lipase activity, this paper also studies the optimal combination of the controllable factors (aeration; agitation and fermentation time that will maximize the cell dry weight.

  10. Fibronectin production by human mammary cells

    Energy Technology Data Exchange (ETDEWEB)

    Stampfer, M.R. (Univ. of California, Berkeley); Vlodavsky, I.; Smith, H.S.; Ford, R.; Becker, F.F.; Riggs, J.

    1981-01-01

    Human mammary cells were examined for the presence of the high-molecular-weight surface glycoprotein fibronectin. Early passage mammary epithelial cell and fibroblast cultures from both carcinomas and normal tissues were tested for the presence of cell-associated fibronectin by immunofluorescence microscopy and for the synthesis and secretion of fibronectin by specific immunoprecipitation of metabolically labeled protein. In vivo frozen sections of primary carcinomas and normal tissues were tested for the localization of fibronectin by immunofluorescence microscopy. In contrast to the extensive fibrillar networks of fibronectin found in the fibroblast cultures, the epithelial cell cultures from both tissue sources displayed a pattern of cell-associated fibronectin characterizd by powdery, punctate staining. However, the cultured epithelial cells, as well as the fibroblasts, secreted large quantities of fibronectin into the medium. Putative myoepithelial cells also displayed extensive fibrillar networks of fibronectin. The difference in cell-associated fibronectin distribution between the epithelial cells and the fibroblasts and putative myoepithelial cells provided a simple means of quantitating stromal and myoepithelial cell contamination of the mammary epithelial cells in culture. In vivo, normal tissues showed fibronectin primarily localized in the basement membrane surrounding the epithelial cells and in the stroma. Most primary carcinomas displayed powdery, punctate staining on the epithelial cells in addition to the fibronectin present in the surrounding stroma.

  11. Methods for Stem Cell Production and Therapy

    Science.gov (United States)

    Claudio, Pier Paolo (Inventor); Valluri, Jagan V. (Inventor)

    2015-01-01

    The present invention relates to methods for rapidly expanding a stem cell population with or without culture supplements in simulated microgravity conditions. The present invention relates to methods for rapidly increasing the life span of stem cell populations without culture supplements in simulated microgravity conditions. The present invention also relates to methods for increasing the sensitivity of cancer stem cells to chemotherapeutic agents by culturing the cancer stem cells under microgravity conditions and in the presence of omega-3 fatty acids. The methods of the present invention can also be used to proliferate cancer cells by culturing them in the presence of omega-3 fatty acids. The present invention also relates to methods for testing the sensitivity of cancer cells and cancer stem cells to chemotherapeutic agents by culturing the cancer cells and cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce tissue for use in transplantation by culturing stem cells or cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce cellular factors and growth factors by culturing stem cells or cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce cellular factors and growth factors to promote differentiation of cancer stem cells under microgravity conditions.

  12. Test Results From The Idaho National Laboratory Of The NASA Bi-Supported Cell Design

    Energy Technology Data Exchange (ETDEWEB)

    C Stoots; J O' Brien; T Cable

    2009-11-01

    The Idaho National Laboratory has been researching the application of solid-oxide fuel cell technology for large-scale hydrogen production. As a result, the Idaho National Laboratory has been testing various cell designs to characterize electrolytic performance. NASA, in conjunction with the University of Toledo, has developed a new cell concept with the goals of reduced weight and high power density. This paper presents results of the INL's testing of this new solid oxide cell design as an electrolyzer. Gas composition, operating voltage, and other parameters were varied during testing. Results to date show the NASA cell to be a promising design for both high power-to-weight fuel cell and electrolyzer applications.

  13. A Comprehensive Framework for Surfactant Selection and Design for Emulsion Based Chemical Product Design

    DEFF Research Database (Denmark)

    Mattei, Michele; Kontogeorgis, Georgios; Gani, Rafiqul

    2014-01-01

    The manufacture of emulsified products is of increasing interest in the consumer oriented chemical indus-try. Several cosmetic, house-hold and pharmaceutical products are in the emulsified form when soldand/or they are expected to form an emulsion when used. Therefore, there is a need for the dev......The manufacture of emulsified products is of increasing interest in the consumer oriented chemical indus-try. Several cosmetic, house-hold and pharmaceutical products are in the emulsified form when soldand/or they are expected to form an emulsion when used. Therefore, there is a need...... ingredientsis consequently necessary to tackle this problem with computer-aided methods and tools. A compre-hensive framework for the selection and design of surfactants, the main responsible for the formationand the stability of emulsions, is presented here together with the modeling of the cloud point, a key......-property of nonionic surfactants, with a group-contribution model. The mathematical formulation of astandard product design problem is presented, together with the list of both the pure component prop-erties (related to nonionic surfactants) and the mixture properties (relevant to the overall products asan emulsion...

  14. Applications of ``PV Optics`` for solar cell and module design

    Energy Technology Data Exchange (ETDEWEB)

    Sopori, B.L.; Madjdpour, J.; Chen, W. [National Renewable Energy Lab., Golden, CO (United States)

    1998-09-01

    This paper describes some applications of a new optics software package, PV Optics, developed for the optical design of solar cells and modules. PV Optics is suitable for the analysis and design of both thick and thin solar cells. It also includes a feature for calculation of metallic losses related to contacts and back reflectors.

  15. Integrated Computer-aided Framework for Sustainable Chemical Product Design and Evaluation

    DEFF Research Database (Denmark)

    Kalakul, Sawitree; Cignitti, Stefano; Zhang, Lei

    2016-01-01

    This work proposes an integrated model-based framework for chemical product design and evaluation based on which the software, VPPD-Lab (The Virtual Product-Process Design Laboratory) has been developed. The framework allows the following options: (1) design a product using design templates...... of the templates for three case studies: (i) the design of a refrigeration cycle, (ii) a mixture/blend design problem involving lubricant design and (iii) a tailor-made product design of jet-fuels (blended chemical products)....

  16. Real cell overlay measurement through design based metrology

    Science.gov (United States)

    Yoo, Gyun; Kim, Jungchan; Park, Chanha; Lee, Taehyeong; Ji, Sunkeun; Jo, Gyoyeon; Yang, Hyunjo; Yim, Donggyu; Yamamoto, Masahiro; Maruyama, Kotaro; Park, Byungjun

    2014-04-01

    Until recent device nodes, lithography has been struggling to improve its resolution limit. Even though next generation lithography technology is now facing various difficulties, several innovative resolution enhancement technologies, based on 193nm wavelength, were introduced and implemented to keep the trend of device scaling. Scanner makers keep developing state-of-the-art exposure system which guarantees higher productivity and meets a more aggressive overlay specification. "The scaling reduction of the overlay error has been a simple matter of the capability of exposure tools. However, it is clear that the scanner contributions may no longer be the majority component in total overlay performance. The ability to control correctable overlay components is paramount to achieve the desired performance.(2)" In a manufacturing fab, the overlay error, determined by a conventional overlay measurement: by using an overlay mark based on IBO and DBO, often does not represent the physical placement error in the cell area of a memory device. The mismatch may arise from the size or pitch difference between the overlay mark and the cell pattern. Pattern distortion, caused by etching or CMP, also can be a source of the mismatch. Therefore, the requirement of a direct overlay measurement in the cell pattern gradually increases in the manufacturing field, and also in the development level. In order to overcome the mismatch between conventional overlay measurement and the real placement error of layer to layer in the cell area of a memory device, we suggest an alternative overlay measurement method utilizing by design, based metrology tool. A basic concept of this method is shown in figure1. A CD-SEM measurement of the overlay error between layer 1 and 2 could be the ideal method but it takes too long time to extract a lot of data from wafer level. An E-beam based DBM tool provides high speed to cover the whole wafer with high repeatability. It is enabled by using the design as a

  17. Design Of Experiments For Product And Process Development: An Applicatıon In Food Production Sector

    OpenAIRE

    HASGÜL, Özlem

    2011-01-01

    The aim of this paper is to use of design of experiments to develop products and processes and to contribute to use it more commonly. In this work, the basic principles related to design of experiments is explained and 23 factorial design set up for food production sector has been constructed. After that, products have been cooked on hot own oven under different process conditions to study their effect on product weight.

  18. Study on Distributed Knowledge Information System for Product Design

    Institute of Scientific and Technical Information of China (English)

    ZHOU Shouqin; CHIN Kwai Sang; LING Weiqing; XIE Youbai

    2001-01-01

    To overcome the limitations of commercial CAD and handbook form of knowledge expression, the Distributed Knowledge Information System (DKIS) for product design is proposed. The structure of DKIS and the key issues in its implementation are introduced; the method of knowledge store and transfer of DKIS is discussed. The mechanism of knowledge representation, acquisition and utilization, based on Internet network, is achieved. Based on the concept of function driven, integrated Artificial Neural Networks and Active Server Pages techniques, transplanting the trained ANN into DKIS system, a new method for retrieving knowledge in DKIS over Internet is achieved. Finally, a prototype of DKIS is developed to demonstrate the feasibility of the structure and constructional method of DKIS. The work provides a scheme for speed knowledge acquisition and shortens the cycle of product development.

  19. INTEGRATED PRODUCT AND ENTERPRISE DESIGN FOR GLOBAL COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    N.D. Du Preez

    2012-01-01

    Full Text Available This paper presentsan overview of the challenge to integrate product and process life cycles in maintaining global competitiveness of an enterprise and proposes IEKOS as a possible solution . It provides the reader with a framework of two virtual life cycles which create a problem solving matrix for the industrial engineer. In this matrix, bordered by the virtual enterprise life cycle and the virtual product life cycles, the business functions of analyze, design deploy and operate are predominantly functions executed by the, industrial engineer. The different phases of each life cycle serves as a framework to a virtual industrial engineering toolkit providing access to detailed functions, formats, examples and a series of software and other "tools" available to the industrial engineer.
    In conclusion a brief overview is provided of the progress of the IEKOS toolkit which is under development at the department of Industrial Engineering at Stellenbosch University.

  20. Fabrication of Complex Optical Components From Mold Design to Product

    CERN Document Server

    Riemer, Oltmann; Gläbe, Ralf

    2013-01-01

    High quality optical components for consumer products made of glass and plastic are mostly fabricated by replication. This highly developed production technology requires several consecutive, well-matched processing steps called a "process chain" covering all steps from mold design, advanced machining and coating of molds, up to the actual replication and final precision measurement of the quality of the optical components. Current market demands for leading edge optical applications require high precision and cost effective parts in large volumes. For meeting these demands it is necessary to develop high quality process chains and moreover, to crosslink all demands and interdependencies within these process chains. The Transregional Collaborative Research Center "Process chains for the replication of complex optical elements" at Bremen, Aachen and Stillwater worked extensively and thoroughly in this field from 2001 to 2012. This volume will present the latest scientific results for the complete process chain...

  1. Design and testing of the Series III AMTEC cell

    Energy Technology Data Exchange (ETDEWEB)

    Mital, R.; Sievers, R.K.

    1999-07-01

    This paper describes the design and testing of the Series III (S3) Alkali Metal Thermal to Electric Converter (AMTEC) cell which is capable of high efficiency (15--25%) and high power density (100--150 W/kg). Compared to the Series 2 cell which is being developed primarily for space power systems, the Series III cell design provides a significantly higher beta{double_prime}-alumina solid electrolyte (BASE) tube packing density around the heat source thereby increasing cell power and minimizing heat loss. The prototype S3 cell will have 96 BASE tubes and is expected to produce about 150 We. In this cell design the BASE tube assemblies are mounted on a cylindrical tube support plate. The BASE tubes are arranged like spokes on a wheel. The inner cylinder, concentric to the tube support plate, is the hot side of the cell and the outer cylinder is the condenser. Since the prototype S3 cell will be the first of its kind, an engineering cell with same dimensions as the prototype but with 24 BASE tubes was built first. The purpose of this cell was to identify and resolve structural, thermal, manufacturing and sodium management issues before launching into the build of a complete 96 BASE tube cell. The engineering cell has been successfully built and tested. The data of the engineering cells have been used to calibrate the SINDA/FLUINT code to predict the prototype cell performance more accurately. The build of the prototype 96 BASE tube cells is now in progress. This paper presents the design and development of the prototype S3 cell. The fabrication and testing of the first S3 engineering cell is discussed next. Based on the test data of the engineering cell, the anticipated thermal performance of the prototype cells predicted by the calibrated SINDA model are also presented.

  2. Adaptability Feature's Concept, Modeling and Application in Product Design

    Institute of Scientific and Technical Information of China (English)

    BaiYuewei; ChenZhuoning; WeiShuangyu; BinHongzan

    2003-01-01

    The current 3D CAD/CAM system, both research prototypes and commercial systems, based on traditional feature modeling are always hampered by the problems in their complicated modeling and difficult maintaining. This paper introduces a new method for modeling parts by using adaptability feature (AF), by which the consistent relationship among parts and assemblies can be maintained in whole design process. In addition, the design process, can be speeded, time-to-market shortened, and product quality improved. Some essential issues of the strategy are discussed. A system, KMCAD3D, by taking advantages of AF has been developed. It is shown that the method discussed is a feasible and effective way to improve current feature modeling technology.

  3. Considerations in designing a centrifugal atomiser for metal powder production

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Y.Y. [Department of Engineering, The University of Liverpool, Liverpool L69 3GH (United Kingdom)]. E-mail: y.y.zhao@livepool.ac.uk

    2006-07-01

    In centrifugal atomisation for metal powder production, the key to the control of the particle sizes is the design of the atomiser. This paper studies the main issues concerned in designing a centrifugal atomiser and provides guidance on the selection of an electric motor, radius of atomiser, slope angle of atomiser wall and flow rate of cooling water. In the selection of the atomiser radius, the power and material constraints as well as the hydraulic jump radius need to be considered. A cup atomiser with a slope angle of 60-70{sup o} would result in small spray droplets and thus a fine powder. The water cooling system needs to be assessed by examining the heat flow in the solid metal layer and in the atomiser.

  4. Feature-based multiresolution techniques for product design

    Institute of Scientific and Technical Information of China (English)

    LEE Sang Hun; LEE Kunwoo

    2006-01-01

    3D computer-aided design (CAD) systems based on feature-based solid modelling technique have been widely spread and used for product design. However, when part models associated with features are used in various downstream applications,simplified models in various levels of detail (LODs) are frequently more desirable than the full details of the parts. In particular,the need for feature-based multiresolution representation of a solid model representing an object at multiple LODs in the feature unit is increasing for engineering tasks. One challenge is to generate valid models at various LODs after an arbitrary rearrangement of features using a certain LOD criterion, because composite Boolean operations consisting of union and subtraction are not commutative. The other challenges are to devise proper topological framework for multiresolution representation, to suggest more reasonable LOD criteria, and to extend applications. This paper surveys the recent research on these issues.

  5. Advanced Turbine Systems (ATS) program conceptual design and product development

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-31

    Achieving the Advanced Turbine Systems (ATS) goals of 60% efficiency, single-digit NO{sub x}, and 10% electric power cost reduction imposes competing characteristics on the gas turbine system. Two basic technical issues arise from this. The turbine inlet temperature of the gas turbine must increase to achieve both efficiency and cost goals. However, higher temperatures move in the direction of increased NO{sub x} emission. Improved coatings and materials technologies along with creative combustor design can result in solutions to achieve the ultimate goal. GE`s view of the market, in conjunction with the industrial and utility objectives, requires the development of Advanced Gas Turbine Systems which encompass two potential products: a new aeroderivative combined-cycle system for the industrial market, and a combined-cycle system for the utility sector that is based on an advanced frame machine. The GE Advanced Gas Turbine Development program is focused on two specific products: (1) a 70 MW class industrial gas turbine based on the GE90 core technology utilizing an innovative air cooling methodology; (2) a 200 MW class utility gas turbine based on an advanced Ge heavy-duty machine utilizing advanced cooling and enhancement in component efficiency. Both of these activities required the identification and resolution of technical issues critical to achieving ATS goals. The emphasis for the industrial ATS was placed upon innovative cycle design and low emission combustion. The emphasis for the utility ATS was placed on developing a technology base for advanced turbine cooling, while utilizing demonstrated and planned improvements in low emission combustion. Significant overlap in the development programs will allow common technologies to be applied to both products. GE Power Systems is solely responsible for offering GE products for the industrial and utility markets.

  6. Computer Aided Product Service Systems Design: Service CAD and Its integration with Life Cycle Simulation

    NARCIS (Netherlands)

    Komoto, H.

    2009-01-01

    Integration of product design into service design, or vice versa, is considered to bring more efficient and effective value addition. Besides EcoDesign tools and methods, a methodology to design such an integration of products and services from a systemic perspective, or product-service systems (PSS

  7. Tissue-specific designs of stem cell hierarchies

    NARCIS (Netherlands)

    Visvader, Jane E; Clevers, Hans

    2016-01-01

    Recent work in the field of stem cell biology suggests that there is no single design for an adult tissue stem cell hierarchy, and that different tissues employ distinct strategies to meet their self-renewal and repair requirements. Stem cells may be multipotent or unipotent, and can exist in quiesc

  8. Development of cell therapy medicinal products by academic institutes.

    Science.gov (United States)

    de Wilde, Sofieke; Guchelaar, Henk-Jan; Herberts, Carla; Lowdell, Mark; Hildebrandt, Martin; Zandvliet, Maarten; Meij, Pauline

    2016-08-01

    In the rapidly evolving fields of cellular immunotherapy, gene therapy and regenerative medicine, a wide range of promising cell therapy medicinal products are in clinical development. Most products originate from academic research and are explored in early exploratory clinical trials. However, the success rate toward approval for regular patient care is disappointingly low. In this paper, we define strengths and hurdles applying to the development of cell therapy medicinal products in academic institutes, and analyze why only a few promising cell therapies have reached late-stage clinical development. Subsequently, we provide recommendations to stakeholders involved in development of cell therapies to exploit their potential clinical benefit.

  9. Arecoline decreases interleukin-6 production and induces apoptosis and cell cycle arrest in human basal cell carcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Li-Wen [Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan (China); Hsieh, Bau-Shan; Cheng, Hsiao-Ling [Department of Biochemistry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan (China); Hu, Yu-Chen [Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan (China); Chang, Wen-Tsan [Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan (China); Division of Hepatobiliarypancreatic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan (China); Chang, Kee-Lung, E-mail: Chang.KeeLung@msa.hinet.net [Department of Biochemistry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan (China); Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan (China)

    2012-01-15

    Arecoline, the most abundant areca alkaloid, has been reported to decrease interleukin-6 (IL-6) levels in epithelial cancer cells. Since IL-6 overexpression contributes to the tumorigenic potency of basal cell carcinoma (BCC), this study was designed to investigate whether arecoline altered IL-6 expression and its downstream regulation of apoptosis and the cell cycle in cultured BCC-1/KMC cells. BCC-1/KMC cells and a human keratinocyte cell line, HaCaT, were treated with arecoline at concentrations ranging from 10 to 100 μg/ml, then IL-6 production and expression of apoptosis- and cell cycle progress-related factors were examined. After 24 h exposure, arecoline inhibited BCC-1/KMC cell growth and decreased IL-6 production in terms of mRNA expression and protein secretion, but had no effect on HaCaT cells. Analysis of DNA fragmentation and chromatin condensation showed that arecoline induced apoptosis of BCC-1/KMC cells in a dose-dependent manner, activated caspase-3, and decreased expression of the anti-apoptotic protein Bcl-2. In addition, arecoline induced progressive and sustained accumulation of BCC-1/KMC cells in G2/M phase as a result of reducing checkpoint Cdc2 activity by decreasing Cdc25C phosphatase levels and increasing p53 levels. Furthermore, subcutaneous injection of arecoline led to decreased BCC-1/KMC tumor growth in BALB/c mice by inducing apoptosis. This study demonstrates that arecoline has potential for preventing BCC tumorigenesis by reducing levels of the tumor cell survival factor IL-6, increasing levels of the tumor suppressor factor p53, and eliciting cell cycle arrest, followed by apoptosis. Highlights: ► Arecoline has potential to prevent against basal cell carcinoma tumorigenesis. ► It has more effectiveness on BCC as compared with a human keratinocyte cell line. ► Mechanisms involved including reducing tumor cells’ survival factor IL-6, ► Decreasing Cdc25C phosphatase, enhancing tumor suppressor factor p53, ► Eliciting G2/M

  10. Designing environmentally friendly products in conformity with the market - a holistic analysis of product characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Oberender, C.; Birkhofer, H. [Darmstadt Univ. of Technology, Inst. for Product Development and Machine Elements, Darmstadt (Germany)

    2004-07-01

    Creating the 'ecological shelf-warmer' and bringing it to the market must be discouraged, since such a product causes environmental impacts during production and at the end-of-life without ever being sold and used. Products must be environmentally friendly as well as conform with the market. This presents a conflict since measures that improve the products' market value often lead to increased environmental impacts and costs, and every product function causes some. The developed Eco-Value Analysis supports the product developer to fulfill environmental and customers' demands and aims at a holistic approach, considering technical, environmental and economical aspects. Based on three portfolios and the results of the Kano-method, recommendations for designing products, which support the environment as well as conform with the market, are given. The method assists developers concerning environmental and ecologic improvements and the realization of functions. The procedure of the Eco-Value Analysis was applied to a household coffee maker. (orig.)

  11. Adaptive designs based on the truncated product method

    Directory of Open Access Journals (Sweden)

    Neuhäuser Markus

    2005-09-01

    Full Text Available Abstract Background Adaptive designs are becoming increasingly important in clinical research. One approach subdivides the study into several (two or more stages and combines the p-values of the different stages using Fisher's combination test. Methods Alternatively to Fisher's test, the recently proposed truncated product method (TPM can be applied to combine the p-values. The TPM uses the product of only those p-values that do not exceed some fixed cut-off value. Here, these two competing analyses are compared. Results When an early termination due to insufficient effects is not appropriate, such as in dose-response analyses, the probability to stop the trial early with the rejection of the null hypothesis is increased when the TPM is applied. Therefore, the expected total sample size is decreased. This decrease in the sample size is not connected with a loss in power. The TPM turns out to be less advantageous, when an early termination of the study due to insufficient effects is possible. This is due to a decrease of the probability to stop the trial early. Conclusion It is recommended to apply the TPM rather than Fisher's combination test whenever an early termination due to insufficient effects is not suitable within the adaptive design.

  12. How will Smart City Production Systems Transform Supply Chain Design: a Product-level investigation

    OpenAIRE

    Kumar, M.; Graham, G; Hennelly, P; Srai, J. S.

    2016-01-01

    This is the accepted manuscript. It is currently embargoed pending publication. This paper is a first step to understand the role that a smart city with a distributed production system could have in changing the nature and form of supply chain design. Since the end of the Second World War most supply chain systems for manufactured products have been based on “scale economies” and “bigness”; in our paper we challenge this traditional view. Our fundamental research question is: how could a s...

  13. Optimizing PHB and Protease Production by Box Behnken Design

    Directory of Open Access Journals (Sweden)

    Amro Abd al fattah Amara

    2013-04-01

    Full Text Available Mixed culture is more suitable to adapt more flexible fermentation process and produce different product simultaneously. In this study a mixed Bacillus culture was investigated for their ability to produce the bioplastic "Polyhydroxybutyrate" and both of the mesophilic and the thermophilic proteases in one flask. Box-Behnken experimental design was used. The produced amount of PHB has been increased significantly. Meanwhile there is a competition between PHB and proteases. The maximum produced amount of PHB using Box-Behnken design was 2.82 g/l/48 h with protease activity equal to 41.9 Units/ml/48 h for thermophilic proteases and 99.65 Units/ml/48 h for mesophilic proteases. Excel solver was used for extra-optimization for the optimum conditions obtained from Box-Behnken experiments and its model. The maximum PHB obtained after using Excel solver was 2.88 g/l/48 h. The maximum mesophilic and thermophilic activities obtained at the same PHB production conditions were 175.68 and 243.38 Units/ml respectively. The model accuracy as obtained from Excel solver was 118.8%, which prove the power of the experimental design in optimizing such complicated process. The strategies used in this study are recommended for the production of PHB and different proteases simultaneously using Bacillus mixed culture. ABSTRAK: Kultur campuran adalah lebih sesuai bagi proses penapaian yang fleksibel dan ia boleh menghasilkan produk yang berbeza secara serentak. Dalam kajian ini keupayaan  menghasilkan "Polyhydroxybutyrate" bioplastik serta mesofilik dan termofilik protease dalam satu flask oleh  kultur Bacillus campuran telah disiasat. Eksperimen rekabentuk Box-Behnken telah digunakan. Jumlah PHB yang dikeluarkan meningkat dengan ketara dan terdapat persaingan antara PHB dan protease. Jumlah keluaran PHB maksima menggunakan rekabentuk Box-Behnken adalah 2.82 g/l/48 jam dengan aktiviti protease sama dengan 41.9 Unit/ml/48 jam untuk protease termofilik dan 99.65 Unit

  14. Strategies for developing design spaces for viral clearance by anion exchange chromatography during monoclonal antibody production.

    Science.gov (United States)

    Strauss, Daniel M; Cano, Tony; Cai, Nick; Delucchi, Heather; Plancarte, Magdalena; Coleman, Daniel; Blank, Gregory S; Chen, Qi; Yang, Bin

    2010-01-01

    The quality-by-design (QbD) regulatory initiative promotes the development of process design spaces describing the multidimensional effects and interactions of process variables on critical quality attributes of therapeutic products. However, because of the complex nature of production processes, strategies must be devised to provide for design space development with reasonable allocation of resources while maintaining highly dependable results. Here, we discuss strategies for the determination of design spaces for viral clearance by anion exchange chromatography (AEX) during purification of monoclonal antibodies. We developed a risk assessment for AEX using a formalized method and applying previous knowledge of the effects of certain variables and the mechanism of action for virus removal by this process. We then use design-of-experiments (DOE) concepts to perform a highly fractionated factorial experiment and show that varying many process parameters simultaneously over wide ranges does not affect the ability of the AEX process to remove endogenous retrovirus-like particles from CHO-cell derived feedstocks. Finally, we performed a full factorial design and observed that a high degree of viral clearance was obtained for three different model viruses when the most significant process parameters were varied over ranges relevant to typical manufacturing processes. These experiments indicate the robust nature of viral clearance by the AEX process as well as the design space where removal of viral impurities and contaminants can be assured. In addition, the concepts and methodology presented here provides a general approach for the development of design spaces to assure that quality of biotherapeutic products is maintained.

  15. Design Report for ACP Hot Cell Rear Door

    Energy Technology Data Exchange (ETDEWEB)

    Ku, J. H.; Kwon, K. C.; Choung, W. M.; Cho, I. J.; Kook, D. H.; Lee, W. K.; You, G. S.; Lee, E. P.; Park, S. W

    2005-12-15

    A hot-cell facility was constructed at the IMEF building for the demonstrate ACP process. ACP hot-cell consists of process cell and maintenance cell, and each cell has rear door. Since this facility was constructed at basement floor, all process materials, equipment and radioactive materials are take in and out through the rear door. Also, this door can be an access route of workers for the maintenance works. Therefore ACP hot-cell rear doors must maintain the radiation shielding, sealing, mechanical and structural safety. This report presents design criteria, design contents of each part and driving part. It was confirmed that the rear doors sufficiently maintain the safety through the structural analysis and shielding analysis. Also, it was confirmed that the rear doors were constructed as designed by the gamma scanning test after the installation.

  16. Heat production of mammalian cells at different cell-cycle phases

    NARCIS (Netherlands)

    Loesberg, C.; Miltenburg, J.C. van; Wuk, R. van

    1982-01-01

    1. 1.|Heat production of Reuber H35 rat hepatoma cells and murine C1300 neuroblastoma cells at different stages of the cell cycle were measured microcalorimetrically. 2. 2.|Reuber H35 monolayer cultures of G1-phase cells and cells in S-phase were trypsinized, reincubated in suspension culture and i

  17. Studio in Advertising Design, Fashion Design and Illustration, Product Design, Stage Design. Volume 3: Advanced Elective Courses in Art for Grades 10, 11, or 12.

    Science.gov (United States)

    New York State Education Dept., Albany. Bureau of Secondary Curriculum Development.

    The document provides teaching guidelines and information on advance elective courses in a studio art program for grades 10, 11, and 12. The courses are presented in four sections: (1) studio in advertising design--advertising and production, lettering, illustrating, and color reproduction; (2) studio in fashion design and illustration--elements…

  18. Growth promoting effects of prebiotic yeast cell wall products in starter broilers under an immune stress and Clostridium perfringens challenge

    Science.gov (United States)

    This study was designed to investigate the growth promoting effects of supplementing different sources and concentrations of prebiotic yeast cell wall (YCW) products containing mannanoligosaccharides in starter broilers under an immune stress and Clostridium perfringens challenge. Through a series ...

  19. Lipopolysaccharide induces IFN-γ production in human NK cells

    Directory of Open Access Journals (Sweden)

    Leonid M Kanevskiy

    2013-01-01

    Full Text Available NK cells have been shown to play a regulatory role in sepsis. According to the current view, NK cells become activated via macrophages or dendritic cells primed by lipopolysaccharide (LPS. Recently TLR4 gene expression was detected in human NK cells suggesting the possibility of a direct action of LPS on NK cells. In this study, effects of LPS on NK cell cytokine production and cytotoxicity were studied using highly purified human NK cells. LPS induced IFN-γ production in the presence of IL-2 in cell populations containing >98% CD56+ cells. Surprisingly, in the same experiments LPS decreased NK cell degranulation. No significant expression of markers related to blood dendritic cells, monocytes or T or B lymphocytes in the NK cell preparations was observed; the portions of HLA-DRbright, CD14+, CD3+ and CD20+ cells amounted to less than 0.1% within the cell populations. No more than 0.2% of NK cells were shown to be slightly positive for surface TLR4 in our experimental system, although intracellular staining revealed moderate amounts of TLR4 inside the NK cell population. These cells were negative for surface CD14, the receptor participating in LPS recognition by TLR4. Incubation of NK cells with IL-2 or/and LPS did not lead to an increase in TLR4 surface expression. TLR4–CD56+ NK cells isolated by cell sorting secreted IFN-γ in response to LPS. Antibody to TLR4 did not block the LPS-induced increase in IFN-γ production. We have also shown that Re-form of LPS lacking outer core oligosaccharide and O-antigen induces less cytokine production in NK cells than full length LPS. We speculate that the polysaccharide fragments of LPS molecule may take part in LPS-induced IFN-γ production by NK cells. Collectively our data suggest the existence of a mechanism of LPS direct action on NK cells distinct from established TLR4-mediated signaling.

  20. Large-scale production of diesel-like biofuels - process design as an inherent part of microorganism development.

    Science.gov (United States)

    Cuellar, Maria C; Heijnen, Joseph J; van der Wielen, Luuk A M

    2013-06-01

    Industrial biotechnology is playing an important role in the transition to a bio-based economy. Currently, however, industrial implementation is still modest, despite the advances made in microorganism development. Given that the fuels and commodity chemicals sectors are characterized by tight economic margins, we propose to address overall process design and efficiency at the start of bioprocess development. While current microorganism development is targeted at product formation and product yield, addressing process design at the start of bioprocess development means that microorganism selection can also be extended to other critical targets for process technology and process scale implementation, such as enhancing cell separation or increasing cell robustness at operating conditions that favor the overall process. In this paper we follow this approach for the microbial production of diesel-like biofuels. We review current microbial routes with both oleaginous and engineered microorganisms. For the routes leading to extracellular production, we identify the process conditions for large scale operation. The process conditions identified are finally translated to microorganism development targets. We show that microorganism development should be directed at anaerobic production, increasing robustness at extreme process conditions and tailoring cell surface properties. All the same time, novel process configurations integrating fermentation and product recovery, cell reuse and low-cost technologies for product separation are mandatory. This review provides a state-of-the-art summary of the latest challenges in large-scale production of diesel-like biofuels.

  1. Liposomal Drug Products: A Quality by Design Approach

    Science.gov (United States)

    Xu, Xiaoming

    Quality by Design (QbD) principles has been applied to the development of two liposomal formulations, containing a hydrophilic small molecule therapeutic (Tenofovir) and a protein therapeutic (superoxide dismutase). The goal of the research is to provide critical information on 1) how to reduce the preparation variability in liposome formulations, and 2) how to increase drug encapsulation inside liposomes to reduce manufacturing cost. Most notably, an improved liposome preparation method was developed which increased the encapsulation efficiency of hydrophilic molecules. In particular, this method allows for very high encapsulation efficiency. For example, encapsulation efficiencies of up to 50% have been achieved, whereas previously only 20% or less have been reported. Another significant outcome from this research is a first principle mathematical model to predict the encapsulation efficiency of hydrophilic drugs in unilamellar liposomes. This mathematical model will be useful in: formulation development to rapidly achieve optimized formulations; comparison of drug encapsulation efficiencies of liposomes prepared using different methods; and assisting in the development of suitable process analytical technologies to achieve real-time monitoring and control of drug encapsulation during manufacturing. A novel two-stage reverse dialysis in vitro release testing method has also been developed for passively targeted liposomes, which uses the first stage to mimic the circulation of liposomes in the body and the second stage to imitate the drug release process at the target. The developed in vitro release testing method can be used to distinguish formulations with varied compositions for quality control testing purposes. This developed method may pave the way to the development of more biorelevant quality control testing methods for liposomal drug products in the future. The QbD case studies performed in this research are examples of how this approach can be used to

  2. Design, Modeling, and Development of Microbial Cell Factories

    KAUST Repository

    Kodzius, Rimantas

    2014-03-26

    Using Metagenomic analysis, computational modeling, single cell and genome editing technologies, we will express desired microbial genes and their networks in suitable hosts for mass production of energy, food, and fine chemicals.

  3. Property Modelling for Applications in Chemical Product and Process Design

    DEFF Research Database (Denmark)

    Gani, Rafiqul

    , polymers, mixtures as well as separation processes. The presentation will highlight the framework (ICAS software) for property modeling, the property models and issues such as prediction accuracy, flexibility, maintenance and updating of the database. Also, application issues related to the use of property......, they are not always available. Also, it may be too expensive to measure them or it may take too much time. In these situations and when repetitive calculations are involved (as in process simulation), it is useful to have appropriate models to reliably predict the needed properties. A collection of methods tools...... such as database, property model library, model parameter regression, and, property-model based product-process design will be presented. The database contains pure component and mixture data for a wide range of organic chemicals. The property models are based on the combined group contribution and atom...

  4. Information delivery manuals to integrate building product information into design

    DEFF Research Database (Denmark)

    Berard, Ole Bengt; Karlshøj, Jan

    2011-01-01

    . Traditional business process modeling languages often fail to completely cover all four perspectives. BuildingSMART has proposed Information Delivery Manuals (IDMs) to model and re-engineer processes that address the four perspectives through a collaborative methodology in order to standardize and implement......Despite continuing BIM progress, professionals in the AEC industry often lack the information they need to perform their work. Although this problem could be alleviated by information systems similar to those in other industries, companies struggle to model processes and information needs......, and (3) to ascertain whether IDM’s business rules can support the development of information and logic-bearing BIM objects. The research is based on a case study of re-engineering the bidding process for a design-build project to integrate building product manufacturers, subcontractors...

  5. Information delivery manuals to integrate building product information into design

    DEFF Research Database (Denmark)

    Berard, Ole Bengt; Karlshøj, Jan

    2013-01-01

    . Traditional business process modeling languages often fail to completely cover all four perspectives. BuildingSMART has proposed Information Delivery Manuals (IDMs) to model and re-engineer processes that address the four perspectives through a collaborative methodology in order to standardize and implement......Despite continuing BIM progress, professionals in the AEC industry often lack the information they need to perform their work. Although this problem could be alleviated by information systems similar to those in other industries, companies struggle to model processes and information needs......, and (3) to ascertain whether IDM's business rules can support the development of information and logic-bearing BIM objects. The research is based on a case study of reengineering the bidding process for a design-build project to integrate building product manufacturers, subcontractors and their knowledge...

  6. Vector Design for Improved DNA Vaccine Efficacy, Safety and Production

    Directory of Open Access Journals (Sweden)

    James A. Williams

    2013-06-01

    Full Text Available DNA vaccination is a disruptive technology that offers the promise of a new rapidly deployed vaccination platform to treat human and animal disease with gene-based materials. Innovations such as electroporation, needle free jet delivery and lipid-based carriers increase transgene expression and immunogenicity through more effective gene delivery. This review summarizes complementary vector design innovations that, when combined with leading delivery platforms, further enhance DNA vaccine performance. These next generation vectors also address potential safety issues such as antibiotic selection, and increase plasmid manufacturing quality and yield in exemplary fermentation production processes. Application of optimized constructs in combination with improved delivery platforms tangibly improves the prospect of successful application of DNA vaccination as prophylactic vaccines for diverse human infectious disease targets or as therapeutic vaccines for cancer and allergy.

  7. LISE++: Exotic beam production with fragment separators and their design

    Science.gov (United States)

    Tarasov, O. B.; Bazin, D.

    2016-06-01

    Since the LISE++ code presentation at the EMIS 2007 conference (Tarasov and Bazin, 2008), important improvements have been made in the analytical and Monte Carlo calculations of transmission, and accuracy of reaction product distributions. In this paper new features of the code in ion-beam optics, creation of new LISE++ blocks, and development of some reaction models will be discussed. Large progress has been done in ion-beam optics with the introduction of "elemental" blocks, that allows optical matrices calculation within LISE++. New type of configurations based on these blocks allow a detailed analysis of the transmission, useful for fragment separator design, and can be used for optics optimization based on user constraints.

  8. Architectural design and production beyond the rule of art

    Directory of Open Access Journals (Sweden)

    Massimo Lauria

    2011-04-01

    Full Text Available In the construction sector among the reasons that raise the idea of a crisis of the project, some related to technical information and its impacts on the construction’s quality.The certainties of the rules of art, lapse in comparison with the new role taken on by production in the decision-making and construction processes and in particular in the relationship designer-enterprise. Any technical solution, it is now difficult to define «conform», because of information sources that instruct it, expected performances, and results at architectural, technical and material level. By increasing uncertainty and risk error. Starting from this background, the paper describes the research activities that take place at DASTEC in Reggio Calabria and that represent some potential solutions.

  9. NASA Alternative Orion Small Cell Battery Design Support

    Science.gov (United States)

    Haynes, Chuck

    2016-01-01

    The NASA Orion Crew Module Reference Design was produced to address large scale thermal runaway (TR) hazard with specific safety controls for the Orion Spacecraft. The design presented provides the description of a full scale battery design reference for implementation as a drop in replacement to meet all spacecraft energy requirements with compatible 120 Vdc electrical and mechanical interface using small cell technology (18650) packaging. The 32V SuperBrick incorporates unique support features and an electrical bus bar arrangement that allows cells negative can insertion into heat sink that is compressively coupled to the battery enclosure to promote good thermal management. The housing design also provides an internal flame suppression "filter tray" and positive venting path internal to the enclosure to allow hot effluent ejecta to escape in the event of single cell TR. Virtual cells (14P Banks) that are supported to provide cell spacing with interstitial materials to prevent side can failures that can produce cell to cell TR propagation. These features were successfully test in four separate TR run with the full scale DTA1 test article in February 2016. Successfully Completed Test Objectives - Four separate TR test runs with Full-Scale DTA1 housing with Two SuperBricks, Two SuperBrick Emulators All Tests resulted in "clean" gas with less than 6 C rise at Battery vent All Tests resulted in less than 2 C temperature rise on cold-plate outlet All Tests resulted in less than 6 psi pressure rise in the battery housing Test Run 1 -One neighbor cell TR, highest remaining neighbor 139 C. Ejecta shorted to bus caused prolonged additional heating, One shorted cell did experience TR after 12 minutes, remaining cells had adequate thermal margin Test Run 2 - No cell to cell propagation, highest neighbor cell 112 C; Test Run 3 - No cell to cell propagation, highest neighbor cell 96 C; Test Run 4 - No cell to cell propagation, highest neighbor cell 101 C; Primary TR testing

  10. The ILC engineering design phase: Towards the production of an engineering design report

    Energy Technology Data Exchange (ETDEWEB)

    Ross, Marc; /Fermilab

    2007-01-01

    In August 2007, the International Linear Collider-Global Design Effort (ILC-GDE) published the ILC Reference Design Report (RDR) which contains a description of the design of the linear collider and a ''value'' cost estimate. The RDR was developed over a 2 year period starting in August 2005 with the creation of the GDE at the Second ILC workshop, held at Snowmass, Colorado. The design described in the RDR and its associated estimate allow the GDE to plan and prioritize the next phase of the ILC, the creation of an Engineering Design and the production, by mid 2010, of an Engineering Design Report (EDR). The EDR will contain, in addition to a more mature design and an updated value estimate, a plan for executing the ILC Project. The purpose of the EDR is to facilitate formal international negotiations at government level on siting, funding, organization and execution of the ILC project with a timescale consistent with the start of construction in 2012. The creation of the ILC Engineering Design will include: (1) Basic R&D to demonstrate that all components can be engineered; (2) R&D into alternative solutions to mitigate remaining risk; (3) An overall design to allow machine construction to start within 3 years following its completion; (4) selection between high tech options to allow industrialization efforts; (5) A comprehensive value-engineering exercise; (6) A complete value cost estimate for the machine, including a funding profile consistent with the project schedule; (7) A project execution plan including a realistic schedule; (8) Designs for facilities shared between different ''area systems'', and for site-specific infrastructure. The designs must include the level of detail needed for regions to estimate the cost to host; and (9) All necessary information must be provided to regions to evaluate project technical and financial risks in support of a bid to host. With the completion of the EDR, the ILC-GDE leadership

  11. [In vitro strategies for human gametes production from stem cells].

    Science.gov (United States)

    Tosca, Lucie; Courtot, Anne-Marie; Bennaceur-Griscelli, Annelise; Tachdjian, Gérard

    2011-10-01

    Embryonic stem cells (ESC) are self-renewal and pluripotent cells that are able to differentiate in vitro into several cell types in favourable conditions. Technical protocols for in vitro gametes production have been developed in mice and human species. The functionality of such differentiated cells is not always analysed and an early meiotic arrest is a current observation. These kinds of experimentations have also been tested from human induced pluripotent stem cells (IPSC). However, differentiation ends shortly at the primordial germ cell stage.

  12. Mould Design and Material selection for Film Insert Moulding of Direct Methanol Fuel Cell Packaging

    DEFF Research Database (Denmark)

    Wöhner, Timo; Senkbeil, S.; Olesen, T. L.

    2015-01-01

    This paper presents the mould design for an injection moulding (IM) process for the production of a methanol container for the use in small, passive Direct Methanol Fuel Cell (DMFC) systems, which are intended to be used in behind-the-ear hearing aid systems. One of the crucial properties...

  13. Broadband back grating design for thin film solar cells

    KAUST Repository

    Janjua, Bilal

    2013-01-01

    In this paper, design based on tapered circular grating structure was studied, to provide broadband enhancement in thin film amorphous silicon solar cells. In comparison to planar structure an absorption enhancement of ~ 7% was realized.

  14. Design of a Fuel Cell Hybrid Electric Vehicle Drive System

    DEFF Research Database (Denmark)

    Schaltz, Erik

    Fuel cells achieve more and more attention due to their potential of replacing the traditional internal combustion engine (ICE) used in the area of transportation. In this PhD thesis a fuel cell shaft power pack (FCSPP) is designed and implemented in a small truck. The FCSPP replaces the original...... the efficiency. In this work a lead-acid battery, an ultracapacitor, or a combination of both are considered as energy storage devices. A FCSPP is designed for 10 different configurations of connecting the energy storage device(s) and fuel cell to a common bus, which comply with the 42V PowerNet standard. Each...... of the ten configurations is designed for different fuel cell power ratings. The FCSPP is designed in an iterative process where the power flow through the system is under the influence of a certain energy management strategy and charging strategy, which sufficiently divides the power between the units...

  15. Effect of failures and repairs on multiple cell production lines

    Energy Technology Data Exchange (ETDEWEB)

    Legato, P.; Bobbio, A.; Roberti, L.

    1989-01-01

    This paper examines a production line composed of multiple stages, or cells, which are passed in sequential order to arrive to the final product. Two possible coordination disciplines are considered, namely: the classical tandem arrangement of sequential working centers with input buffer and the kanban scheme, considered the Japanese shop floor realization of the Just-In-Time (JIT) manifacturing approach. The production line is modelled and analysed by means of Stochastic Petri Nets (SPN). Finally an analysis is made of the possibility that the working cells can incur failure/repair cycles perturbing the production flow of the line and thus reduce performance indices.

  16. Risk Management in Product Design: Current State, Conceptual Model and Future Research

    OpenAIRE

    Oehmen, Josef; Seering, Warren; Ben-Daya, Mohamed; Al-Salamah, Muhammad

    2010-01-01

    Risk management is an important element of product design. It helps to minimize the project- and product-related risks such as project budget and schedule overrun, or missing product cost and quality targets. Risk management is especially important for complex, international product design projects that involve a high degree of novel technology. This paper reviews the literature on risk management in product design. It examines the newly released international standard ISO 31000 “Risk managem...

  17. Design and Simulation of a Quaternary Memory Cell based on a Physical Memristor

    DEFF Research Database (Denmark)

    Nannarelli, Alberto; Taylor, Jonathan

    2016-01-01

    Memristors were theorized more than fifty years ago, but only recently physical devices with memristor’s behavior have been fabricated and shipped. In this work, we experiment on one of these physical memristors by designing a memristorbased memory cell, implementing the cell, and testing it. Our...... experiments demonstrate that the memristor technology is not yet mature for practical applications, but, nevertheless, when production will provide reliable and dependable devices, memristorbased memory systems may replace CMOS memories with some advantages....

  18. Cell immobilization for microbial production of 1,3-propanediol.

    Science.gov (United States)

    Gungormusler-Yilmaz, Mine; Cicek, Nazim; Levin, David B; Azbar, Nuri

    2016-01-01

    Cell and enzyme immobilization are often used for industrial production of high-value products. In recent years, immobilization techniques have been applied to the production of value-added chemicals such as 1,3-Propanediol (1,3-PDO). Biotechnological fermentation is an attractive alternative to current 1,3-PDO production methods, which are primarily thermochemical processes, as it generates high volumetric yields of 1,3-PDO, is a much less energy intensive process, and generates lower amounts of environmental organic pollutants. Although several approaches including: batch, fed-batch, continuous-feed and two-step continuous-feed were tested in suspended systems, it has been well demonstrated that cell immobilization techniques can significantly enhance 1,3-PDO production and allow robust continuous production in smaller bioreactors. This review covers various immobilization methods and their application for 1,3-PDO production.

  19. Design & development of innovative proton exchange membrane fuel cells

    OpenAIRE

    Carton, James

    2011-01-01

    The research undertaken in this thesis is concerned with the design and development of Proton Exchange Membrane (PEM) fuel cells and provides a body of information for continued PEM fuel cell development, which will ideally aid in the future commercialisation of these electrochemical devices. Through a combination of numerical analysis, computational fluid dynamic modelling and experimental work, effective flow plate designs, flow field configurations and materials are analysed and new inn...

  20. NASA's Space Launch Transitions: From Design to Production

    Science.gov (United States)

    Askins, Bruce; Robinson, Kimberly

    2016-01-01

    NASA's Space Launch System (SLS) successfully completed its Critical Design Review (CDR) in 2015, a major milestone on the journey to an unprecedented era of exploration for humanity. CDR formally marked the program's transition from design to production phase just four years after the program's inception and the first such milestone for a human launch vehicle in 40 years. While challenges typical of a complex development program lie ahead, CDR evaluators concluded that the design is technically and programmatically sound and ready to press forward to Design Certification Review (DCR) and readiness for launch of Exploration Mission 1 (EM-1) in the 2018 timeframe. SLS is prudently based on existing propulsion systems, infrastructure and knowledge with a clear, evolutionary path as required by mission needs. In its initial configuration, designated Block I, SLS will a minimum of 70 metric tons (t) of payload to low Earth orbit (LEO). It can evolve to a 130 t payload capacity by upgrading its engines, boosters, and upper stage, dramatically increasing the mass and volume of human and robotic exploration while decreasing mission risk, increasing safety, and simplifying ground and mission operations. CDR was the central programmatic accomplishment among many technical accomplishments that will be described in this paper. The government/industry SLS team successfully test fired a flight-like five-segment solid rocket motor, as well as seven hotfire development tests of the RS-25 core stage engine. The majority of the major test article and flight barrels, rings, and domes for the core stage liquid oxygen, liquid hydrogen, engine section, intertank, and forward skirt were manufactured at NASA's Michoud Assembly Facility. Renovations to the B-2 test stand for stage green run testing were completed at NASA Stennis Space Center. Core stage test stands are rising at NASA Marshall Space Flight Center. The modified Pegasus barge for core stage transportation from manufacturing

  1. Design of smart functional apparel products for moxa moxibustion

    Science.gov (United States)

    Li, Li; Au, Wai-man; Ding, Feng; Wong, Kwok-shing

    2013-08-01

    Moxa Moxibustion is a common traditional Chinese therapy in which burning Moxa is applied to affected body areas. This method has been employed for thousands of years to achieve certain medical objectives, such as pain relief or antibacterial and anti-inflammatory effects. Its therapeutic effectiveness has been demonstrated successfully both in research and clinical studies. However, this traditional approach may cause undesirable side effects, for example: 1) burning of Moxa produces by-products such as smoke and ash; 2) patients are at risk of being burnt; 3) the active ingredients of the Moxa leaf oil are volatile, odorous, unstable in air and easy to dissipate, and difficult to store and transport; 4) it is inconvenient to operate. These side effects limit its further high-potential and high-value applications. This study is aimed at developing a multi-functional smart textile system that will adopt smart fabrics containing encapsulated Moxa oil integrated with thermally conductive materials to replace the conventional Moxa products. This will efficiently deliver the active ingredients of Moxa to a human body at optimum conditions, i.e., in a precise and controllable way, with maximum convenience and a high level of comfort. Doing so would solve the existing problems mentioned above. Both garment design skill and textile technology will be applied to Moxa Moxibustion textile to enhance the aesthetics and functionality. The smart garment performance will be assessed subjectively in a clinical trial and objectively by a number of instrumental methods.

  2. Designer nanoparticle: nanobiotechnology tool for cell biology

    Science.gov (United States)

    Thimiri Govinda Raj, Deepak B.; Khan, Niamat Ali

    2016-09-01

    This article discusses the use of nanotechnology for subcellular compartment isolation and its application towards subcellular omics. This technology review significantly contributes to our understanding on use of nanotechnology for subcellular systems biology. Here we elaborate nanobiotechnology approach of using superparamagnetic nanoparticles (SPMNPs) optimized with different surface coatings for subcellular organelle isolation. Using pulse-chase approach, we review that SPMNPs interacted differently with the cell depending on its surface functionalization. The article focuses on the use of functionalized-SPMNPs as a nanobiotechnology tool to isolate high quality (both purity and yield) plasma membranes and endosomes or lysosomes. Such nanobiotechnology tool can be applied in generating subcellular compartment inventories. As a future perspective, this strategy could be applied in areas such as immunology, cancer and stem cell research.

  3. A retrosynthetic biology approach to metabolic pathway design for therapeutic production

    Directory of Open Access Journals (Sweden)

    Faulon Jean-Loup

    2011-08-01

    Full Text Available Abstract Background Synthetic biology is used to develop cell factories for production of chemicals by constructively importing heterologous pathways into industrial microorganisms. In this work we present a retrosynthetic approach to the production of therapeutics with the goal of developing an in situ drug delivery device in host cells. Retrosynthesis, a concept originally proposed for synthetic chemistry, iteratively applies reversed chemical transformations (reversed enzyme-catalyzed reactions in the metabolic space starting from a target product to reach precursors that are endogenous to the chassis. So far, a wider adoption of retrosynthesis into the manufacturing pipeline has been hindered by the complexity of enumerating all feasible biosynthetic pathways for a given compound. Results In our method, we efficiently address the complexity problem by coding substrates, products and reactions into molecular signatures. Metabolic maps are represented using hypergraphs and the complexity is controlled by varying the specificity of the molecular signature. Furthermore, our method enables candidate pathways to be ranked to determine which ones are best to engineer. The proposed ranking function can integrate data from different sources such as host compatibility for inserted genes, the estimation of steady-state fluxes from the genome-wide reconstruction of the organism's metabolism, or the estimation of metabolite toxicity from experimental assays. We use several machine-learning tools in order to estimate enzyme activity and reaction efficiency at each step of the identified pathways. Examples of production in bacteria and yeast for two antibiotics and for one antitumor agent, as well as for several essential metabolites are outlined. Conclusions We present here a unified framework that integrates diverse techniques involved in the design of heterologous biosynthetic pathways through a retrosynthetic approach in the reaction signature space

  4. Engineering the supply chain for protein production/secretion in yeasts and mammalian cells.

    Science.gov (United States)

    Klein, Tobias; Niklas, Jens; Heinzle, Elmar

    2015-03-01

    Metabolic bottlenecks play an increasing role in yeasts and mammalian cells applied for high-performance production of proteins, particularly of pharmaceutical ones that require complex posttranslational modifications. We review the present status and developments focusing on the rational metabolic engineering of such cells to optimize the supply chain for building blocks and energy. Methods comprise selection of beneficial genetic modifications, rational design of media and feeding strategies. Design of better producer cells based on whole genome-wide metabolic network analysis becomes increasingly possible. High-resolution methods of metabolic flux analysis for the complex networks in these compartmented cells are increasingly available. We discuss phenomena that are common to both types of organisms but also those that are different with respect to the supply chain for the production and secretion of pharmaceutical proteins.

  5. Conceptual layout design of CFETR Hot Cell Facility

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Zheng, E-mail: gongz@mail.ustc.edu.cn [University of Science and Technology of China, Hefei 230026 (China); Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Qi, Minzhong, E-mail: qiminzhong@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Cheng, Yong, E-mail: chengyong@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Song, Yuntao, E-mail: songyt@ipp.ac.cn [University of Science and Technology of China, Hefei 230026 (China); Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China)

    2015-11-15

    Highlights: • This article proposed a conceptual layout design for CFETR. • The design principles are to support efficient maintenance to ensure the realization of high duty time. • The preliminary maintenance process and logistics are described in detail. • Life cycle management, maneuverability, risk and safety are in the consideration of design. - Abstract: CFETR (China Fusion Engineering Test Reactor) is new generation of Tokomak device beyond EAST in China. An overview of hot cell layout design for CFETR has been proposed by ASIPP&USTC. Hot Cell, as major auxiliary facility, not only plays a pivotal role in supporting maintenance to meet the requirements of high duty time 0.3–0.5 but also supports installation and decommissioning. Almost all of the Tokomak devices are lateral handling internal components like ITER and JET, but CFETR maintain the blanket module from 4 vertical ports, which is quite a big challenge for the hot cell layout design. The activated in-vessel components and several diagnosis instruments will be repaired and refurbished in the Hot Cell Facility, so the appropriate layout is very important to the Hot Cell Facility to ensure the high duty time, it is divided into different parts equipped with a variety of RH equipment and diagnosis devices based on the functional requirements. The layout of the Hot Cell Facility should make maintenance process more efficient and reliable, and easy to service and rescue when a sudden events taking place, that is the capital importance issue considered in design.

  6. Symbolic Meaning Integration in Design and its Influence on Product and Brand Evaluation

    NARCIS (Netherlands)

    Rompay, van Thomas; Pruyn, Ad; Tieke, Peter

    2009-01-01

    Previous research and theorizing in product design and consumer psychology testifies to the importance of congruence among symbolic meanings connoted through elements in visual communications such as advertisements, product appearance, and product packaging. However, understanding of the processes w

  7. Influences of three-dimensional printing to product innovation design thinking

    Directory of Open Access Journals (Sweden)

    Liu Ling

    2017-01-01

    Full Text Available The increasing demand of individuation brings new challenges to traditional product design. This paper studies and analyzes three-dimensional print technology promotes the future development of product innovation design. The advantages of 3D printing equipment can help creative products enterprises shorten product manufacturing period and make them powerful in competition.

  8. Influences of three-dimensional printing to product innovation design thinking

    OpenAIRE

    Liu Ling; Wang Xu; Guo Ping

    2017-01-01

    The increasing demand of individuation brings new challenges to traditional product design. This paper studies and analyzes three-dimensional print technology promotes the future development of product innovation design. The advantages of 3D printing equipment can help creative products enterprises shorten product manufacturing period and make them powerful in competition.

  9. Cell fusion in tumor progression: the isolation of cell fusion products by physical methods

    Directory of Open Access Journals (Sweden)

    Vincitorio Massimo

    2011-09-01

    Full Text Available Abstract Background Cell fusion induced by polyethylene glycol (PEG is an efficient but poorly controlled procedure for obtaining somatic cell hybrids used in gene mapping, monoclonal antibody production, and tumour immunotherapy. Genetic selection techniques and fluorescent cell sorting are usually employed to isolate cell fusion products, but both procedures have several drawbacks. Results Here we describe a simple improvement in PEG-mediated cell fusion that was obtained by modifying the standard single-step procedure. We found that the use of two PEG undertreatments obtains a better yield of cell fusion products than the standard method, and most of these products are bi- or trinucleated polykaryocytes. Fusion rate was quantified using fluorescent cell staining microscopy. We used this improved cell fusion and cell isolation method to compare giant cells obtained in vitro and giant cells obtained in vivo from patients with Hodgkin's disease and erythroleukemia. Conclusions In the present study we show how to improve PEG-mediated cell fusion and that cell separation by velocity sedimentation offers a simple alternative for the efficient purification of cell fusion products and to investigate giant cell formation in tumor development.

  10. Sesamin Ameliorates Advanced Glycation End Products-Induced Pancreatic β-Cell Dysfunction and Apoptosis

    Directory of Open Access Journals (Sweden)

    Xiang Kong

    2015-06-01

    Full Text Available Advanced glycation end products (AGEs, the direct modulators of β-cells, have been shown to cause insulin-producing β-cell dysfunction and apoptosis through increase of intracellular reactive oxygen species (ROS production. Sesamin has been demonstrated to possess antioxidative activity. This study was designed to investigate whether sesamin protects against AGEs-evoked β-cell damage via its antioxidant property. The effects of sesamin were examined in C57BL/6J mice and MIN6 cell line. In in vivo studies, mice were intraperitoneally injected with AGEs (120 mg/kg and orally treated with sesamin (160 mg/kg for four weeks. Intraperitoneal glucose tolerance and insulin releasing tests were performed. Insulin content, ROS generation and β-cell apoptosis in pancreatic islets were also measured. In in vitro studies, MIN6 cells were pretreated with sesamin (50 or 100 μM and then exposed to AGEs (200 mg/L for 24 h. Insulin secretion, β-cell death, ROS production as well as expression and activity of NADPH oxidase were determined. Sesamin treatment obviously ameliorated AGE-induced β-cell dysfunction and apoptosis both in vivo and in vitro. These effects were associated with decreased ROS production, down-regulated expression of p67phox and p22phox, and reduced NADPH oxidase activity. These results suggest that sesamin protects β-cells from damage caused by AGEs through suppressing NADPH oxidase-mediated oxidative stress.

  11. Sesamin Ameliorates Advanced Glycation End Products-Induced Pancreatic β-Cell Dysfunction and Apoptosis.

    Science.gov (United States)

    Kong, Xiang; Wang, Guo-Dong; Ma, Ming-Zhe; Deng, Ru-Yuan; Guo, Li-Qun; Zhang, Jun-Xiu; Yang, Jie-Ren; Su, Qing

    2015-06-09

    Advanced glycation end products (AGEs), the direct modulators of β-cells, have been shown to cause insulin-producing β-cell dysfunction and apoptosis through increase of intracellular reactive oxygen species (ROS) production. Sesamin has been demonstrated to possess antioxidative activity. This study was designed to investigate whether sesamin protects against AGEs-evoked β-cell damage via its antioxidant property. The effects of sesamin were examined in C57BL/6J mice and MIN6 cell line. In in vivo studies, mice were intraperitoneally injected with AGEs (120 mg/kg) and orally treated with sesamin (160 mg/kg) for four weeks. Intraperitoneal glucose tolerance and insulin releasing tests were performed. Insulin content, ROS generation and β-cell apoptosis in pancreatic islets were also measured. In in vitro studies, MIN6 cells were pretreated with sesamin (50 or 100 μM) and then exposed to AGEs (200 mg/L) for 24 h. Insulin secretion, β-cell death, ROS production as well as expression and activity of NADPH oxidase were determined. Sesamin treatment obviously ameliorated AGE-induced β-cell dysfunction and apoptosis both in vivo and in vitro. These effects were associated with decreased ROS production, down-regulated expression of p67(phox) and p22(phox), and reduced NADPH oxidase activity. These results suggest that sesamin protects β-cells from damage caused by AGEs through suppressing NADPH oxidase-mediated oxidative stress.

  12. An in silico platform for the design of heterologous pathways in nonnative metabolite production

    Directory of Open Access Journals (Sweden)

    Chatsurachai Sunisa

    2012-05-01

    Full Text Available Abstract Background Microorganisms are used as cell factories to produce valuable compounds in pharmaceuticals, biofuels, and other industrial processes. Incorporating heterologous metabolic pathways into well-characterized hosts is a major strategy for obtaining these target metabolites and improving productivity. However, selecting appropriate heterologous metabolic pathways for a host microorganism remains difficult owing to the complexity of metabolic networks. Hence, metabolic network design could benefit greatly from the availability of an in silico platform for heterologous pathway searching. Results We developed an algorithm for finding feasible heterologous pathways by which nonnative target metabolites are produced by host microorganisms, using Escherichia coli, Corynebacterium glutamicum, and Saccharomyces cerevisiae as templates. Using this algorithm, we screened heterologous pathways for the production of all possible nonnative target metabolites contained within databases. We then assessed the feasibility of the target productions using flux balance analysis, by which we could identify target metabolites associated with maximum cellular growth rate. Conclusions This in silico platform, designed for targeted searching of heterologous metabolic reactions, provides essential information for cell factory improvement.

  13. SEMICONDUCTOR DEVICES: Optimization of grid design for solar cells

    Science.gov (United States)

    Wen, Liu; Yueqiang, Li; Jianjun, Chen; Yanling, Chen; Xiaodong, Wang; Fuhua, Yang

    2010-01-01

    By theoretical simulation of two grid patterns that are often used in concentrator solar cells, we give a detailed and comprehensive analysis of the influence of the metal grid dimension and various losses directly associated with it during optimization of grid design. Furthermore, we also perform the simulation under different concentrator factors, making the optimization of the front contact grid for solar cells complete.

  14. CFD-aided cell settler design optimization and scale-up: effect of geometric design and operational variables on separation performance.

    Science.gov (United States)

    Shen, Yuyi; Yanagimachi, Kurt

    2011-01-01

    The inclined multiplate (lamella) gravity settler has proven to be an effective cell retention device in industrial perfusion cell culture applications. Investigations on the effects of geometric design and operational variables of the cell settler are crucial to understanding how to best improve the settler performance. Maximizing the harvest/perfusion flow rate while minimizing viable cell loss out of the harvest is the primary challenge for optimization of the settler design. This study demonstrated that computational fluid dynamics (CFD) can be utilized to accurately model and evaluate the settler separation performance for near-monodisperse suspensions and therefore aid in the design optimization of the settler under these baseline conditions. With the preferred geometric features that were identified from CFD modeling results, we proposed design guidelines for the scale-up of these multiplate settler systems. With these guidelines and performance verification using the CFD model, a new large-scale settler was designed and fabricated for a perfusion cell culture process using a minimally aggregating production cell line. Perfusion cell culture runs with this particular cell line were performed with this settler, and the CFD model was able to predict the initial ramp-up performance, proving it to be a valuable scale-up design tool for this production process.

  15. Cognitive ergonomics and production information systems under the gaze of interdisciplinary design or industrial design.

    Science.gov (United States)

    Mattos, Luciene Bulhões

    2012-01-01

    The core of this work involves the study of cognitive ergonomics and production of Information Systems under the interdisciplinary of the Design or Industrial Design. It is assumed that in the dynamics of human and the systems, mediated by systematic technology, there are constant changes in social perceptions, that alter the shape of the subject dealing with the real world, concrete, adopting a pseudo-idea of the evolutionary process. Attentive to the interdisciplinary and transdisciplinary groups as agents of this process, points to the danger of the emergence of the myth of innovation as a solver of social problems and suggests new ergonomics as a contributor in a different way of thinking the humanization beyond of the XXI century.

  16. Viral vaccines and their manufacturing cell substrates: New trends and designs in modern vaccinology.

    Science.gov (United States)

    Rodrigues, Ana F; Soares, Hugo R; Guerreiro, Miguel R; Alves, Paula M; Coroadinha, Ana S

    2015-09-01

    Vaccination is one of the most effective interventions in global health. The worldwide vaccination programs significantly reduced the number of deaths caused by infectious agents. A successful example was the eradication of smallpox in 1979 after two centuries of vaccination campaigns. Since the first variolation administrations until today, the knowledge on immunology has increased substantially. This knowledge combined with the introduction of cell culture and DNA recombinant technologies revolutionized vaccine design. This review will focus on vaccines against human viral pathogens, recent developments on vaccine design and cell substrates used for their manufacture. While the production of attenuated and inactivated vaccines requires the use of the respective permissible cell substrates, the production of recombinant antigens, virus-like particles, vectored vaccines and chimeric vaccines requires the use - and often the development - of specific cell lines. Indeed, the development of novel modern viral vaccine designs combined with, the stringent safety requirements for manufacture, and the better understanding on animal cell metabolism and physiology are increasing the awareness on the importance of cell line development and engineering areas. A new era of modern vaccinology is arriving, offering an extensive toolbox to materialize novel and creative ideas in vaccine design and its manufacture.

  17. RESEARCH ON THE GENERALIZED MODULAR DESIGN METHOD WITH FLEXIBLE MODULES OF PRODUCT STRUCTURES

    Institute of Scientific and Technical Information of China (English)

    Xu Yanshen; Xu Qianli; Chen Yongliang; Hou Liang

    2004-01-01

    A new generalized modular design (GMD) method is proposed based on design practice of frame structure of hydraulic press machines. By building a series of flexible modules (FMs), design knowledge and structure features are integrated into parametric models. Then, parametric design and variational analysis methods for GMD are presented according to user defined design objectives and customized product characteristics. A FM-centered GMD system is developed and successfully used in the rapid design of relevant products.

  18. Proinflammatory interleukins' production by adipose tissue-derived mesenchymal stromal cells: the impact of cell culture conditions and cell-to-cell interaction.

    Science.gov (United States)

    Andreeva, Elena; Andrianova, Irina; Rylova, Julia; Gornostaeva, Aleksandra; Bobyleva, Polina; Buravkova, Ludmila

    2015-08-01

    The impact of culture conditions and interaction with activated peripheral blood mononuclear cells on the interleukin (IL) gene expression profile and proinflammatory IL-6 and IL-8 production by adipose-derived stromal cells (ASCs) was investigated. A microarray analysis revealed a wide range of IL genes either under standard (20%) or hypoxic (5%) O2 concentrations, some highly up-regulated at hypoxia. IL-6 and IL-8 production was inversely dependent on cell culture density. In early (first-third) passages, IL-6 and IL-8 concentration was higher at 20% O2 and in late (8th-12th) passages under 5% O2. Interaction between ASCs and mononuclear cells in indirect setting was accompanied with a significant decrease of IL-6 and did not result in the elevation of IL-8 concentration. Thereby, the production of proinflammatory interleukins (IL-6 and IL-8) may be affected by the ASC intrinsic features (density in culture, and duration of expansion), as well as by microenvironmental factors, such as hypoxia and the presence of blood-borne cells. These data are important for elucidating ASC paracrine activity regulation in vitro. They would also be on demand for optimisation of the cell therapy protocols, based on the application of ASC biologically active substances. SIGNIFICANCE PARAGRAPH: Ex vivo expansion is widely used for increasing the number of adipose-derived stromal cells (ASCs) and improving of their quality. The present study was designed to elucidate the particular factors influencing the interleukin production in ASCs. The presented data specified the parameters (i.e. cell density, duration of cultivation, hypoxia, etc.) that should be taken in mind when ASCs are intended to be used in protocols implying their paracrine activity. These data would be of considerable interest for researchers and clinicians working in the biomedical science.

  19. Cell culture media impact on drug product solution stability.

    Science.gov (United States)

    Purdie, Jennifer L; Kowle, Ronald L; Langland, Amie L; Patel, Chetan N; Ouyang, Anli; Olson, Donald J

    2016-07-08

    To enable subcutaneous administration of monoclonal antibodies, drug product solutions are often needed at high concentrations. A significant risk associated with high drug product concentrations is an increase in aggregate level over the shelf-life dating period. While much work has been done to understand the impact of drug product formulation on aggregation, there is limited understanding of the link between cell culture process conditions and soluble aggregate growth in drug product. During cell culture process development, soluble aggregates are often measured at harvest using cell-free material purified by Protein A chromatography. In the work reported here, cell culture media components were evaluated with respect to their impact on aggregate levels in high concentration solution drug product during accelerated stability studies. Two components, cysteine and ferric ammonium citrate, were found to impact aggregate growth rates in our current media (version 1) leading to the development of new chemically defined media and concentrated feed formulations. The new version of media and associated concentrated feeds (version 2) were evaluated across four cell lines producing recombinant IgG4 monoclonal antibodies and a bispecific antibody. In all four cell lines, the version 2 media reduced aggregate growth over the course of a 12 week accelerated stability study compared with the version 1 media, although the degree to which aggregate growth decreased was cell line dependent. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:998-1008, 2016.

  20. Innovation in product design as a factor for reducing logistic and production costs

    Directory of Open Access Journals (Sweden)

    Luciana Fighera Marzall

    2016-03-01

    Full Text Available Innovation has been considered of fundamental importance for organizations competing in dynamic environments, which along with cost management has been shown as an organizational strategy that allows the company to measure its results and implement measures that impact on the organization's performance as a whole. This paper, carried out in a metal mechanical industry of a telecommunications engineering branch, aims to analyse cost reduction in logistics raw materials areas through innovation in the product design, which are antennas and towers for telephone networks. In terms of methodology, this study presents itself as a qualitative and quantitative research-action, which from the link between theory and practice allows for intervention in the middle of the researchers studied. As a result, an innovative project was developed, which allowed for the reduction costs of production by 68% and logistics by 32%. Despite the significant decrease in costs, the quality of manufactured products not declined and customer needs were met, thus making the company more competitive against competitors. Not widespread in the literature, this analysis of the impact on logistics and production costs due to improvements in the project is the main contribution theoretical of this paper.

  1. BBU design of linear induction accelerator cells for radiography application

    Energy Technology Data Exchange (ETDEWEB)

    Shang, C.C.; Chen, Y.J.; Gaporaso, G.J.; Houck, T.L.; Molau, N.E.; Focklen, J.; Gregory, S.

    1997-05-06

    There is an ongoing effort to develop accelerating modules for high-current electron accelerators for advanced radiography application. Accelerating modules with low beam-cavity coupling impedances along with gap designs with acceptable field stresses comprise a set of fundamental design criteria. We examine improved cell designs which have been developed for accelerator application in several radiographic operating regimes. We evaluate interaction impedances, analyze the effects of beam structure coupling on beam dynamics (beam break-up instability and corkscrew motion). We also provide estimates of coupling through interesting new high-gradient insulators and evaluate their potential future application in induction cells.

  2. Advanced laser processing in fuel cells production

    Energy Technology Data Exchange (ETDEWEB)

    Stollhof, J.; Havrilla, D.; Schaupp, R. [TRUMPF Inc., Plymouth, MI (United States); Loeffler, K. [TRUMPF Laser und Systemtechnik TLD, Ditzingen (Germany)

    2009-07-01

    This paper discussed TRUMPF methods of joining bipolar plates to create fuel cell stacks and manufacture thin foils using diode pumped solid state lasers (DPSSLs). Beam delivery systems and processing optics were discussed. CW disk lasers were used to allow spot diameters smaller than 30 {mu}m and combined with a Galvo technology-based scanning optics systems to enable welding speeds greater than 1 m/s. A TruFiber 300 diffraction limited fiber laser was used for CW laser cutting. Short and ultra-short laser pulses were used to drill thousands of holes per second without a measurable heat-affected zone. The attributes and specifications of the 3 major TRUMPF lasers developed to manufacture fuel cells were also provided.

  3. Contending stigma in product design: using insights from social psychology as a stepping stone for design strategies

    NARCIS (Netherlands)

    Vaes, K.R.V.; Stappers, P.J.; Standaert, A.; Desager, K.

    2012-01-01

    Assistive, protective or medical products that are visibly worn or used in proximity to the human body can have an emotional impact on their users and bystanders. In his design effort it is important for a designer to be mindful of the potential stigma a product might elicit. The identity threat mod

  4. Design Principles for Nickel/Hydrogen Cells and Batteries

    Science.gov (United States)

    Thaller, Lawrence H.; Manzo, Michelle A.; Gonzalez-Sanabria, Olga D.

    1987-01-01

    Individual-pressure-vessel (IPV) nickel/hydrogen cells and bipolar batteries developed for use as energy-storage subsystems for satelite applications. Design principles applied draw upon extensive background in separator technology, alkaline-fuel-cell technology and several alkaline-cell technology areas. Principals are rather straightforward applications of capillary-force formalisms, coupled with slowly developing data base resulting from careful post-test analyses. Based on preconceived assumptions relative to how devices work and how to be designed so they display longer cycle lives at deep discharge.

  5. Research on Concurrent Design of Collaborative Product Commerce Oriented Discrete Manufacturing Enterprises

    Institute of Scientific and Technical Information of China (English)

    刘丽兰; 俞涛; 方明伦; 王晓红

    2003-01-01

    In order to fulfill the product concurrent design requirements of discrete manufacturing enterprises, this paper puts forth for the first time a Collaborative Product Commerce (CPC) oriented X2D (X to Design) theory, which can take Collaboration, Commerce and Concurrence (3C) into realization during the product design stage. At the same time, this research adopts VPN (Virtual Private Network) technique to ensure the security of product data and information during transportation. By building CPC-oriented and VPN-based framework of X2D product concurrent design system, the paper explores a way for discrete enterprises adapting to the drastically competitive market and performing their product innovation.

  6. Designing RNA-based genetic control systems for efficient production from engineered metabolic pathways.

    Science.gov (United States)

    Stevens, Jason T; Carothers, James M

    2015-02-20

    Engineered metabolic pathways can be augmented with dynamic regulatory controllers to increase production titers by minimizing toxicity and helping cells maintain homeostasis. We investigated the potential for dynamic RNA-based genetic control systems to increase production through simulation analysis of an engineered p-aminostyrene (p-AS) pathway in E. coli. To map the entire design space, we formulated 729 unique mechanistic models corresponding to all of the possible control topologies and mechanistic implementations in the system under study. Two thousand sampled simulations were performed for each of the 729 system designs to relate the potential effects of dynamic control to increases in p-AS production (total of 3 × 10(6) simulations). Our analysis indicates that dynamic control strategies employing aptazyme-regulated expression devices (aREDs) can yield >10-fold improvements over static control. We uncovered generalizable trends in successful control architectures and found that highly performing RNA-based control systems are experimentally tractable. Analyzing the metabolic control state space to predict optimal genetic control strategies promises to enhance the design of metabolic pathways.

  7. COS-1 cells as packaging host for production of lentiviruses.

    Science.gov (United States)

    MacKenzie, Crystal J; Shioda, Toshi

    2011-03-01

    We present a protocol for in vitro production of recombinant lentiviruses using COS-1 African green monkey kidney epithelial cells and HEK293T human embryonic kidney epithelial cells as packaging cells. COS-1 and HEK293T express SV40 large T antigen, amplifying transfected circular plasmids harboring SV40 replication origin. Support protocols for evaluation of transfection efficiency by in situ β-galactosidase enzyme activity assay and titer of infection-capable virions are also provided. Advantages of using COS-1 packaging cells over the standard HEK293T cells for contamination-sensitive applications or automated processing are discussed.

  8. Contributions of cell subsets to cytokine production during normal and impaired wound healing.

    Science.gov (United States)

    Mirza, Rita E; Koh, Timothy J

    2015-02-01

    The objective of this study was to determine the relative contributions of different cell subsets to the production of cytokines and growth factors during normal and impaired wound healing. Cells were isolated from wounds of non-diabetic and diabetic mice and separated by magnetic sorting into neutrophils/T cells/B cells (NTB cell subset), monocytes/macrophages (Mo/Mp subset) and non-leukocytic cells including keratinocyte/fibroblast/endothelial cells (KFE subset). On both per cell and total contribution bases, the Mo/Mp subset was the dominant producer of pro-inflammatory cytokines interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6 in both non-diabetic and diabetic mice and was a significant producer of vascular endothelial cell growth factor (VEGF)-A, insulin-like growth factor (IGF)-1 and transforming growth factor (TGF)-β1. The NTB subset was also a significant producer of TNF-α and IL-10 whereas the KFE subset contributed significant amounts of VEGF, IGF-1 and TGF-β1. Sustained production of pro-inflammatory cytokines and impaired production of healing-associated factors were evident in each subset in diabetic mice. These data will be useful for further experimental and modeling studies on the role of cell subsets in wound healing as well as for designing therapeutic strategies for improving healing.

  9. Host cells and methods for production of isobutanol

    Energy Technology Data Exchange (ETDEWEB)

    Anthony, Larry Cameron; He, Hongxian; Huang, Lixuan Lisa; Okeefe, Daniel P.; Kruckeberg, Arthur Leo; Li, Yougen; Maggio-Hall, Lori Ann; McElvain, Jessica; Nelson, Mark J.; Patnaik, Ranjan; Rothman, Steven Cary

    2016-08-23

    Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.

  10. Recombinant protein production from stable mammalian cell lines and pools.

    Science.gov (United States)

    Hacker, David L; Balasubramanian, Sowmya

    2016-06-01

    We highlight recent developments for the production of recombinant proteins from suspension-adapted mammalian cell lines. We discuss the generation of stable cell lines using transposons and lentivirus vectors (non-targeted transgene integration) and site-specific recombinases (targeted transgene integration). Each of these methods results in the generation of cell lines with protein yields that are generally superior to those achievable through classical plasmid transfection that depends on the integration of the transfected DNA by non-homologous DNA end-joining. This is the main reason why these techniques can also be used for the generation of stable cell pools, heterogenous populations of recombinant cells generated by gene delivery and genetic selection without resorting to single cell cloning. This allows the time line from gene transfer to protein production to be reduced.

  11. Graphics Innovation Design Based on Cell Intuition Simulation Method

    Institute of Scientific and Technical Information of China (English)

    XIA Zhi-qiu; REN Na; ZHAO Ting-ting; CUI Lun-feng

    2014-01-01

    This paper proposes a new cell intuition simulation method which is a combination of intuitive simulation calculation method and the operation of binary image, and applied it in the innovation of the graphic design process. First of all, we study how to express a variety of graphics, and establish the definition of cell intuitive model, work out the cell intuitive operation process and many new cellular operators such as a variety of matrix blocks crossover operator, a variety of matrix blocks mutation operator, matrix blocks replace operator, matrix blocks compression operator, matrix blocks extension operator. By choosing two or more cells and selecting the artificial selection or fitness selection, we can set up and visualize the design and pick the best design results .Finally, validation is made on this algorithm by an example, and a innovation graphic is also represented.

  12. Mucin production and mucous cell metaplasia in otitis media

    DEFF Research Database (Denmark)

    Lin, Jizhen; Caye-Thomasen, Per; Tono, Tetsuya;

    2012-01-01

    process of OM with mucoid effusion, especially disorders of mucin production resulting from middle ear bacterial infection and Eustachian tube dysfunction. In this review, we will focus on several aspects of this disorder by analyzing the cellular and molecular events such as mucin production and mucous...... cell differentiation in the middle ear mucosa with OM. In addition, infectious agents, mucin production triggers, and relevant signaling pathways will be discussed....

  13. Design and performance of a prototype fuel cell powered vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Lehman, P.A.; Chamberlin, C.E. [Humboldt State Univ., Arcata, CA (United States)

    1996-12-31

    The Schatz Energy Research Center (SERC) is now engaged in the Palm Desert Renewable Hydrogen Transportation System Project. The Project involves a consortium which includes the City of Palm Desert, SERC, the U.S. Department of Energy, the South Coast Air Quality Management District, and Sandia and Lawrence Livermore National Laboratories. Its goal to develop a clean and sustainable transportation system for a community will be accomplished by producing a fleet of fuel cell vehicles, installing a refueling infrastructure utilizing hydrogen generated from solar and wind power, and developing and staffing a fuel cell service and diagnostic center. We will describe details of the project and performance goals for the fuel cell vehicles and associated peripheral systems. In the past year during the first stage in the project, SERC has designed and built a prototype fuel cell powered personal utility vehicle (PUV). These steps included: (1) Designing, building, and testing a 4.0 kW proton exchange membrane (PEM) fuel cell as a power plant for the PUV. (2) Designing, building and testing peripherals including the air delivery, fuel storage/delivery, refueling, water circulation, cooling, and electrical systems. (3) Devising a control algorithm for the fuel cell power plant in the PUV. (4) Designing and building a test bench in which running conditions in the PUV could be simulated and the fuel cell and its peripheral systems tested. (5) Installing an onboard computer and associated electronics into the PUV (6) Assembling and road testing the PUV.

  14. [Promising technologies of packed red blood cells production and storage].

    Science.gov (United States)

    Maksimov, A G; Golota, A S; Krassiĭ, A B

    2013-10-01

    The current article is dedicated to promising technologies of packed red blood cells production and storage. The following new technical approaches are presented: (1) erythrocytes storage in strict anaerobic argon-hydrogen environment, (2) lyophilization of erythrocyte suspension by its atomization in nitrogen gas, (3) lyophilization of erythrocytes by directional freezing under the influence of radio frequency radiation, (4) automated pharming of antigen free packed red blood cells from progenitor cell directly at the battlefield.

  15. Design of a beneficial product for newborn calves by combining Lactobacilli, minerals, and vitamins.

    Science.gov (United States)

    Maldonado, Natalia Cecilia; Silva de Ruiz, Clara; Nader-Macías, María Elena Fátima

    2016-10-01

    Diarrhea is one of the most frequent diseases affecting newborn calves in intensive systems. Several strategies were proposed to protect and improve health, such as probiotics. This work was directed to design a product containing freeze-dried bacteria, vitamins, and minerals, as well as to optimize conditions with lyoprotectors, combine strains and add vitamins, minerals, and inulin to the product. The lyoprotectors were milk, milk-whey, and actose, and products were stored for 6 months at 4°C. Combined bacteria were freeze-dried in milk and the final products were added with minerals, vitamins, and insulin. The viable cells were determined by the plate count assay and antibiotic profiles to differentiate strains. Lactobacillus johnsonii CRL1693, L. murinus CRL1695, L. mucosae CRL1696, L. salivarius CRL1702, L. amylovorus CRL1697, and Enterococcus faecium CRL1703 were evaluated. The optimal conditions were different for each strain. Milk and milk whey maintained the viability during the process and storage after 6 months for most of the strains, except for L. johnsonii. Lactose did not improve cell's recovery. L. murinus was viable for 6 months in all the conditions, with similar results in enterococci. In strains combined before freeze-dried, the viability decreased deeply, showing that one-step process with bacteria mixtures, vitamins, and minerals were not adequate. Freeze-dried resistance depends on each strain and must be lyophilized individually.

  16. Large Scale Production of Stem Cells and Their Derivatives

    Science.gov (United States)

    Zweigerdt, Robert

    Stem cells have been envisioned to become an unlimited cell source for regenerative medicine. Notably, the interest in stem cells lies beyond direct therapeutic applications. They might also provide a previously unavailable source of valuable human cell types for screening platforms, which might facilitate the development of more efficient and safer drugs. The heterogeneity of stem cell types as well as the numerous areas of application suggests that differential processes are mandatory for their in vitro culture. Many of the envisioned applications would require the production of a high number of stem cells and their derivatives in scalable, well-defined and potentially clinical compliant manner under current good manufacturing practice (cGMP). In this review we provide an overview on recent strategies to develop bioprocesses for the expansion, differentiation and enrichment of stem cells and their progenies, presenting examples for adult and embryonic stem cells alike.

  17. Bioreactor production of secondary metabolites from cell cultures of periwinkle and sandalwood.

    Science.gov (United States)

    Valluri, Jagan V

    2009-01-01

    A bench-top bioreactor allowing continuous extraction of secondary metabolites is designed for Catharanthus roseus L. (G.) Don (periwinkle) and Santalum album L. (sandalwood) plant cell suspensions. Periwinkle cell cultures are exposed to biotic elicitors (Aspergillus niger, crude chitin) and abiotic elicitors (mannitol, methyl jasmonate) to induce alkaloid production. Whereas most of the biotic elicitors are effective when added on day 15 of culture, the abiotic elicitors are effective when added on day 20. The use of trans-cinnamic acid, an inhibitor of phenylalanine ammonia lyase (PAL) activity, results in significant increase in the alkaloid production of periwinkle cell cultures. Exposure of the cells to mannitol-induced osmotic stress produced marked increment in the total alkaloid production. When biotic and abiotic stress treatments are applied sequentially, an additive effect in alkaloid accumulation is observed. Although no essential oils are detected, secondary metabolites in the form of phenolics are produced by the sandalwood cell cultures in the bioreactor environment. The use of morphologic modification such as organ cultures and transformed cultures is believed to be required for both production and storage of essential oil constituents in sandalwood. The present chapter demonstrates that periwinkle and sandalwood cell suspensions could be developed and successfully cultured in a modified air-lift bioreactor. The exploitation of variant cell strains and biotransformation of added precursors can certainly improve the use of periwinkle and sandalwood cell cultures for the bioproduction of desired compounds.

  18. Center for Intelligent Fuel Cell Materials Design

    Energy Technology Data Exchange (ETDEWEB)

    Santurri, P.R., (Chemsultants International); Hartmann-Thompson, C.; Keinath, S.E. (Michigan Molecular Inst.)

    2008-08-26

    The goal of this work was to develop a composite proton exchange membrane utilizing 1) readily available, low cost materials 2) readily modified and 3) easily processed to meet the chemical, mechanical and electrical requirements of high temperature PEM fuel cells. One of the primary goals was to produce a conducting polymer that met the criteria for strength, binding capability for additives, chemical stability, dimensional stability and good conductivity. In addition compatible, specialty nanoparticles were synthesized to provide water management and enhanced conductivity. The combination of these components in a multilayered, composite PEM has demonstrated improved conductivity at high temperatures and low humidity over commercially available polymers. The research reported in this final document has greatly increased the knowledge base related to post sulfonation of chemically and mechanically stable engineered polymers (Radel). Both electrical and strength factors for the degree of post sulfonation far exceed previous data, indicating the potential use of these materials in suitable proton exchange membrane architectures for the development of fuel cells. In addition compatible, hydrophilic, conductive nano-structures have been synthesized and incorporated into unique proton exchange membrane architectures. The use of post sulfonation for the engineered polymer and nano-particle provide cost effective techniques to produce the required components of a proton exchange membrane. The development of a multilayer proton exchange membrane as described in our work has produced a highly stable membrane at 170°C with conductivities exceeding commercially available proton exchange membranes at high temperatures and low humidity. The components and architecture of the proton exchange membrane discussed will provide low cost components for the portable market and potentially the transportation market. The development of unique components and membrane architecture

  19. Production of solar photovoltaic cells on the Moon

    Science.gov (United States)

    Criswell, David R.; Ignatiev, Alex

    1991-01-01

    Solar energy is directly available on the sunward lunar surface. Most, if not all, the materials are available on the Moon to make silicon based solar photovoltaic cells. A few additional types are possible. There is a small but growing literature on production of lunar derived solar cells. This literature is reviewed. Topics explored include trade-offs of local production versus import of key materials, processing options, the scale and nature of production equipment, implications of storage requirements, and the end-uses of the energy. Directions for future research and demonstrations are indicated.

  20. Green design assessment of electromechanical products based on group weighted-AHP

    Science.gov (United States)

    Guo, Jinwei; Zhou, MengChu; Li, Zhiwu; Xie, Huiguang

    2015-11-01

    Manufacturing industry is the backbone of a country's economy while environmental pollution is a serious problem that human beings must face today. The green design of electromechanical products based on enterprise information systems is an important method to solve the environmental problem. The question on how to design green products must be answered by excellent designers via both advanced design methods and effective assessment methods of electromechanical products. Making an objective and precise assessment of green design is one of the problems that must be solved when green design is conducted. An assessment method of green design on electromechanical products based on Group Weighted-AHP (Analytic Hierarchy Process) is proposed in this paper, together with the characteristics of green products. The assessment steps of green design are also established. The results are illustrated via the assessment of a refrigerator design.

  1. Plant cell walls throughout evolution: towards a molecular understanding of their design principles

    Energy Technology Data Exchange (ETDEWEB)

    Sarkar, Purbasha; Bosneaga, Elena; Auer, Manfred

    2009-02-16

    Throughout their life, plants typically remain in one location utilizing sunlight for the synthesis of carbohydrates, which serve as their sole source of energy as well as building blocks of a protective extracellular matrix, called the cell wall. During the course of evolution, plants have repeatedly adapted to their respective niche,which is reflected in the changes of their body plan and the specific design of cell walls. Cell walls not only changed throughout evolution but also are constantly remodelled and reconstructed during the development of an individual plant, and in response to environmental stress or pathogen attacks. Carbohydrate-rich cell walls display complex designs, which together with the presence of phenolic polymers constitutes a barrier for microbes, fungi, and animals. Throughout evolution microbes have co-evolved strategies for efficient breakdown of cell walls. Our current understanding of cell walls and their evolutionary changes are limited as our knowledge is mainly derived from biochemical and genetic studies, complemented by a few targeted yet very informative imaging studies. Comprehensive plant cell wall models will aid in the re-design of plant cell walls for the purpose of commercially viable lignocellulosic biofuel production as well as for the timber, textile, and paper industries. Such knowledge will also be of great interest in the context of agriculture and to plant biologists in general. It is expected that detailed plant cell wall models will require integrated correlative multimodal, multiscale imaging and modelling approaches, which are currently underway.

  2. Towards an Approach to Link Knowledge and Prediction in Product Design

    OpenAIRE

    Marconnet, Bertrand; Demoly, Frédéric; Monticolo, Davy; Gomes, Samuel

    2015-01-01

    Part 5: Languages and Ontologies; International audience; Nowadays the knowledge reuse in product design is part of the main challenging issues in product lifecycle management, especially in the earlier stages. Indeed, over the last decade concurrent engineering principles have introduced numerous constraints to be well balanced and considered in product design regarding the whole product lifecycle. Designers need to be aware of their decisions and require assistance in their routine activiti...

  3. An investigation into the Eco-design of Energy Using Products directive.

    Science.gov (United States)

    Meech, Christina Goodrick

    2006-01-01

    This study reviews the eco-design of energy using products directive and additional legislation on the way that waste electrical and electronic equipment should be disposed of, and how this may influence the future product design of appliances. During the investigation 'lifecycle analysis' and consumers' responses to this legislation, and the industry were also reviewed. Finally, for future product designers who work with electrical and electronic equipment some guidelines and rules are given to consider while designing for the environment and sustainability.

  4. A METHOD OF IMPROVING THE PRODUCTION OF BIOMASS OR A DESIRED PRODUCT FROM A CELL

    DEFF Research Database (Denmark)

    1998-01-01

    the F¿1? ATPase or portions thereof is expressed, may be selected from prokaryotes and eukaryotes. In particular the DNA encoding F¿1? or a portion thereof may be derived from bacteria and eukaryotic microorganisms such as yeasts, other fungi and cell lines of higher organisms and be selected from......The production of biomass or a desired product from a cell can be improved by inducing conversion of ATP to ADP without primary effects on other cellular metabolites or functions which is achieved by expressing an uncoupled ATPase activity in said cell and incubating the cell with a suitable...... substrate to produce said biomass or product. This is conveniently done by expressing in said cell the soluble part (F¿1?) of the membrane bound (F¿0?F¿1? type) H?+¿-ATPase or a portion of F¿1? exhibiting ATPase activity. The organism from which the F¿1? ATPase or portions thereof is derived, or in which...

  5. Conceptual design report -- Gasification Product Improvement Facility (GPIF)

    Energy Technology Data Exchange (ETDEWEB)

    Sadowski, R.S.; Skinner, W.H.; House, L.S.; Duck, R.R. [CRS Sirrine Engineers, Inc., Greenville, SC (United States); Lisauskas, R.A.; Dixit, V.J. [Riley Stoker Corp., Worcester, MA (United States); Morgan, M.E.; Johnson, S.A. [PSI Technology Co., Andover, MA (United States). PowerServe Div.; Boni, A.A. [PSI-Environmental Instruments Corp., Andover, MA (United States)

    1994-09-01

    The problems heretofore with coal gasification and IGCC concepts have been their high cost and historical poor performance of fixed-bed gasifiers, particularly on caking coals. The Gasification Product Improvement Facility (GPIF) project is being developed to solve these problems through the development of a novel coal gasification invention which incorporates pyrolysis (carbonization) with gasification (fixed-bed). It employs a pyrolyzer (carbonizer) to avoid sticky coal agglomeration caused in the conventional process of gradually heating coal through the 400 F to 900 F range. In so doing, the coal is rapidly heated sufficiently such that the coal tar exists in gaseous form rather than as a liquid. Gaseous tars are then thermally cracked prior to the completion of the gasification process. During the subsequent endothermic gasification reactions, volatilized alkali can become chemically bound to aluminosilicates in (or added to) the ash. To reduce NH{sub 3} and HCN from fuel born nitrogen, steam injection is minimized, and residual nitrogen compounds are partially chemically reduced in the cracking stage in the upper gasifier region. Assuming testing confirms successful deployment of all these integrated processes, future IGCC applications will be much simplified, require significantly less mechanical components, and will likely achieve the $1,000/kWe commercialized system cost goal of the GPIF project. This report describes the process and its operation, design of the plant and equipment, site requirements, and the cost and schedule. 23 refs., 45 figs., 23 tabs.

  6. Recombinant host cells and media for ethanol production

    Science.gov (United States)

    Wood, Brent E; Ingram, Lonnie O; Yomano, Lorraine P; York, Sean W

    2014-02-18

    Disclosed are recombinant host cells suitable for degrading an oligosaccharide that have been optimized for growth and production of high yields of ethanol, and methods of making and using these cells. The invention further provides minimal media comprising urea-like compounds for economical production of ethanol by recombinant microorganisms. Recombinant host cells in accordance with the invention are modified by gene mutation to eliminate genes responsible for the production of unwanted products other than ethanol, thereby increasing the yield of ethanol produced from the oligosaccharides, relative to unmutated parent strains. The new and improved strains of recombinant bacteria are capable of superior ethanol productivity and yield when grown under conditions suitable for fermentation in minimal growth media containing inexpensive reagents. Systems optimized for ethanol production combine a selected optimized minimal medium with a recombinant host cell optimized for use in the selected medium. Preferred systems are suitable for efficient ethanol production by simultaneous saccharification and fermentation (SSF) using lignocellulose as an oligosaccharide source. The invention also provides novel isolated polynucleotide sequences, polypeptide sequences, vectors and antibodies.

  7. Operation of polymer electrolyte membrane fuel cells with dry feeds: Design and operating strategies

    Science.gov (United States)

    Hogarth, Warren H. J.; Benziger, Jay B.

    The operation of polymer electrolyte membrane fuel cells (PEMFCs) with dry feeds has been examined with different fuel cell flow channel designs as functions of pressure, temperature and flow rate. Auto-humidified (or self-humidifying) PEMFC operation is improved at higher pressures and low gas velocities where axial dispersion enhances "back-mixing" of the product water with the dry feed. We demonstrate auto-humidified operation of the channel-less, self-draining fuel cell, based on a stirred tank reactor; data is presented showing auto-humidified operation from 25 to 115 °C at 1 and 3 atm. Design and operating requirements are derived for the auto-humidified operation of the channel-less, self-draining fuel cell. The auto-humidified self-draining fuel cell outperforms a fully humidified serpentine flow channel fuel cell at high current densities. The new design offers substantial benefits for simplicity of operation and control including: the ability to self-drain reducing flooding, the ability to uniformly disperse water removing current gradients and the ability to operate on dry feeds eliminating the need for humidifiers. Additionally, the design lends itself well to a modular design concept.

  8. Design and fabrication of wraparound contact silicon solar cells

    Science.gov (United States)

    Scott-Monck, J. A.; Stella, P. M.; Avery, J. E.

    1972-01-01

    Both dielectric insulation and etched junction contact techniques were evaluated for use in wraparound contact cell fabrication. Since a suitable process for depositing the dielectrics was not achieved, the latter approach was taken. The relationship between loss of back contact and power degradation due to increased series resistance was established and used to design a simple contact configuration for 10 ohm-cm etched wraparound junction contact N/P cells. A slightly deeper junction significantly improved cell curve shape and the associated loss of current was regained by using thinner contact grid fingers. One thousand cells with efficiencies greater than 10.5% were fabricated to demonstrate the process.

  9. In silico Design of "Un-Natural" Natural Products

    Directory of Open Access Journals (Sweden)

    Zucko; J. ...(et al.

    2008-05-01

    ClustScan, which are under development to model these processes in silico. The heart of CompGen is a specially structured database, based on BioSQL v1.29, which connects the biosynthetic order of synthase/synthetase enzymes to the sequences of the component polypeptides. The additional linkage to the gene sequences allows the integration of DNA sequence with product structure. The database contains sequences of the well-characterised PKS/NRPS clusters, and non-annotated sequenced clusters whose structure and functionis yet unknown, to act as building blocks for the production of novel products. It is easy to add custom sequences to the database and to annotate them by the use of propriety protein profiles designed by Pfam database and HMMER. One function of the program is the ability to generate virtual recombinants between clusters. This can be done using a recombination model (with optional parameters to predict sites for homologous recombination or by user defined recombination sites (e.g. to model in vitro genetic manipulation such as module replacement. The program predicts the linear polyketide structure of the resulting "un-natural" natural products with a chemical description using isomeric SMILES. Molecular modelling of the subsequent spontaneous cyclisation process produces structures for a virtual compound database for further molecular modelling studies using PASS and CDD technology. An optional "reverse genetics" module analyses a given chemical structure to see if it could be produced by a novel PKS/NRPS synthesis cluster and suggests the DNA sequence of a suitable cluster based on building blocks derived from clusters contained in the database.Overall, the CompGen allows in silico generation of the database of novel "un-natural" natural chemical compounds that can be used for in silico screening using PASS or CDD technology. The other integral generic program package, ClustScan, will recognise and annotate new gene clusters from microbial genome

  10. Influence of scaffold design on 3D printed cell constructs.

    Science.gov (United States)

    Souness, Auryn; Zamboni, Fernanda; Walker, Gavin M; Collins, Maurice N

    2017-02-14

    Additive manufacturing is currently receiving significant attention in the field of tissue engineering and biomaterial science. The development of precise, affordable 3D printing technologies has provided a new platform for novel research to be undertaken in 3D scaffold design and fabrication. In the past, a number of 3D scaffold designs have been fabricated to investigate the potential of a 3D printed scaffold as a construct which could support cellular life. These studies have shown promising results; however, few studies have utilized a low-cost desktop 3D printing technology as a potential rapid manufacturing route for different scaffold designs. Here six scaffold designs were manufactured using a Fused deposition modeling, a "bottom-up" solid freeform fabrication approach, to determine optimal scaffold architecture for three-dimensional cell growth. The scaffolds, produced from PLA, are coated using pullulan and hyaluronic acid to assess the coating influence on cell proliferation and metabolic rate. Scaffolds are characterized both pre- and postprocessing using water uptake analysis, mechanical testing, and morphological evaluation to study the inter-relationships between the printing process, scaffold design, and scaffold properties. It was found that there were key differences between each scaffold design in terms of porosity, diffusivity, swellability, and compressive strength. An optimal design was chosen based on these physical measurements which were then weighted in accordance to design importance based on literature and utilizing a design matrix technique. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2017.

  11. Development of a yeast cell factory for production of aromatic products

    DEFF Research Database (Denmark)

    Rodriguez Prado, Edith Angelica; Kildegaard, Kanchana Rueksomtawin; Li, Mingji

    2014-01-01

    There is much interest in aromatic chemicals in the chemical industry as these can be used for production of dyes, anti-oxidants, nutraceuticals and food ingredients. Yeast is a widely used cell factory and it is particularly well suited for production of aromatic chemicals via complex biosynthetic...

  12. Design as a Process of Inquiry, Dialogic Products and Learning-Centred Research Practices

    DEFF Research Database (Denmark)

    Gunn, Wendy; Said Mosleh, Wafa; Andersen, Pernille Viktoria

    2015-01-01

    to address the following questions: How do you engage university researchers and company partners in the collaborative design of energy efficient products? How do you engage teenagers in the future design of public libraries? Working across multiple field sites and the interaction design-teaching studio, we...... products play in opening lines of design inquiry within multi-stakeholder design and field practices involving a diversity of communities engaged in university, public, private research partnerships....

  13. From Design to Production Control Through the Integration of Engineering Data Management and Workflow Management Systems

    CERN Document Server

    Le Goff, J M; Bityukov, S; Estrella, F; Kovács, Z; Le Flour, T; Lieunard, S; McClatchey, R; Murray, S; Organtini, G; Vialle, J P; Bazan, A; Chevenier, G

    1997-01-01

    At a time when many companies are under pressure to reduce "times-to-market" the management of product information from the early stages of design through assembly to manufacture and production has become increasingly important. Similarly in the construction of high energy physics devices the collection of ( often evolving) engineering data is central to the subsequent physics analysis. Traditionally in industry design engineers have employed Engineering Data Management Systems ( also called Product Data Management Systems) to coordinate and control access to documented versions of product designs. However, these systems provide control only at the collaborative design level and are seldom used beyond design. Workflow management systems, on the other hand, are employed in industry to coordinate and support the more complex and repeatable work processes of the production environment. Commer cial workflow products cannot support the highly dynamic activities found both in the design stages of product developmen...

  14. Swarm-Optimization-Based Affective Product Design Illustrated by a Mobile Phone Case-Study

    Directory of Open Access Journals (Sweden)

    Koffka Khan

    2012-05-01

    Full Text Available This paper presents a new approach of user-oriented design for transforming users’ perception into product elements design. An experimental study on mobile phones is conducted to examine how product form and product design parameters affect consumer’s perception of a product. The concept of Kansei Engineering is used to extract the experimental samples as a data base for neural networks (NNs with particle swarm optimization (PSO analysis. The result of numerical analysis suggests that mobile phone makers need to focus on particular design parameters to attract specific target user groups, in addition to product forms. This paper demonstrates the advantage of using KE-PSO for determining the optimal combination of product design parameters. Based on the analysis, we can use KE-PSO to suggest customers’ preferences for mobile phone design attributes that would be considered optimal by various user groups of all surveyed. They can be used for improvement and development of new future products.

  15. Host cell proteins in biotechnology-derived products: A risk assessment framework.

    Science.gov (United States)

    de Zafra, Christina L Zuch; Quarmby, Valerie; Francissen, Kathleen; Vanderlaan, Martin; Zhu-Shimoni, Judith

    2015-11-01

    To manufacture biotechnology products, mammalian or bacterial cells are engineered for the production of recombinant therapeutic human proteins including monoclonal antibodies. Host cells synthesize an entire repertoire of proteins which are essential for their own function and survival. Biotechnology manufacturing processes are designed to produce recombinant therapeutics with a very high degree of purity. While there is typically a low residual level of host cell protein in the final drug product, under some circumstances a host cell protein(s) may copurify with the therapeutic protein and, if it is not detected and removed, it may become an unintended component of the final product. The purpose of this article is to enumerate and discuss factors to be considered in an assessment of risk of residual host cell protein(s) detected and identified in the drug product. The consideration of these factors and their relative ranking will lead to an overall risk assessment that informs decision-making around how to control the levels of host cell proteins.

  16. Investigation Of Designers Intentions And A Users’ Perception Of Product Character

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Boelskifte, Per

    2006-01-01

    Products can be designed to have a character, i.e. a mood that is conveyed through the form of the product, the use of material and colour. Industrial designers often design a consumer product to target a particular market segment with a particular lifestyle or age group. Therefore, the character...... of a product is intended to appeal to the target user group. This paper investigates the similarities and/or differences between: the associations that are made by a user of a product with those that were the intention of the designer....

  17. Designs and Architectures for the Next Generation of Organic Solar Cells

    Directory of Open Access Journals (Sweden)

    Kang-Shyang Liao

    2010-06-01

    Full Text Available Organic solar cells show great promise as an economically and environmentally friendly technology to utilize solar energy because of their simple fabrication processes and minimal material usage. However, new innovations and breakthroughs are needed for organic solar cell technology to become competitive in the future. This article reviews research efforts and accomplishments focusing on three issues: power conversion efficiency, device stability and processability for mass production, followed by an outlook for optimizing OSC performance through device engineering and new architecture designs to realize next generation organic solar cells.

  18. Recent Developments in Cell Vibration Testing at ABSL Space Products

    Science.gov (United States)

    Roberts, Sam; Thwaite, Carl

    2014-08-01

    This paper will describe vibration testing performed at ABSL in recent years on 18650 lithium-ion cells, focussing on work done to expand knowledge of the newest cells (the HCM and NL cells) under random vibration loads. COTS cells as used by ABSL are not necessarily designed for vibration tolerance, and so understanding the conditions that cause failures, and the precise failure modes, is a critical activity.The approach used for cell testing will be described, including the test setup and overall test and analysis flow. In particular, two different approaches (using fixed and resonating interfaces) will be described. The results of survival testing performed on HCM and NL cells will be presented. In addition, the damping behaviour of the HC cell will be described.

  19. H2 PRODUCTION AND FUEL CELLS.

    Energy Technology Data Exchange (ETDEWEB)

    WANG, X.; RODRIGUEZ, J.A.

    2006-06-30

    Oxide nanosystems play a key role as components of catalysts used for the production of H{sub 2} via the steam reforming or the partial oxidation of hydrocarbons, and for the water-gas shift reaction. The behavior seen for Cu-ceria and Au-ceria WGS catalysts indicates that the oxide is much more than a simple support. The special chemical properties of the oxide nanoparticles (defect rich, high mobility of oxygen) favor interactions with the reactants or other catalyst components. More in-situ characterization and mechanistic studies are necessary for the optimization of these nanocatalysts. The use of oxide nanomaterials for the fabrication of PEMFCs and SOFCs can lead to devices with a high practical impact. One objective is to build electrodes with low cost conducting oxide nanoarrays. The electron and oxygen-ion conducting capabilities of many oxides improve when going from the bulk to the nanoscale. Furthermore, one can get a more homogeneous surface morphology and an increase of the effective reaction area. Much more fundamental and practical research needs to be done in this area.

  20. Hydrogen production from proteins via electrohydrogenesis in microbial electrolysis cells.

    Science.gov (United States)

    Lu, Lu; Xing, Defeng; Xie, Tianhui; Ren, Nanqi; Logan, Bruce E

    2010-08-15

    Microorganisms can produce hydrogen gas (H(2)) at high rates by fermentation of carbohydrates, but not from proteins. However, it is possible to produce H(2) at high rates and yields from proteins by electrohydrogenesis in microbial electrolysis cells (MECs). Hydrogen gas was generated using bovine serum albumin (BSA, 700 mg/L) in a single-chamber MEC at a rate of Q=0.42+/-0.07 m(3)/m(3)/day and a yield of Y(H2) = 21.0 +/- 5.0 mmol-H2/g-COD, with an energy recovery (relative to electrical input) of eta(E)=75+/-12% (applied voltage of 0.6 V). Hydrogen production was substantially reduced using a complex protein (peptone) under the same conditions, to Q=0.05+/-0.01 m(3)/m(3)/day, YH2 = 2.6 +/- 0.1 mmol-H2/g-COD, and eta(E)=14+/-3%. There was good removal of organic matter for both substrates in terms of either protein (87+/-6 -97 +/-2%) or total COD (86+/-2 - 91+/-2%). Electron recycling likely occurred as Coulombic efficiencies exceeded 100% using BSA. The use of a two-chamber design, with either a CEM or AEM membrane, reduced the hydrogen production rate, but did not appreciably affect the hydrogen yield or energy efficiency. When an MEC was first acclimated to acetate, and then switched to BSA, performance was substantially reduced and was similar to that obtained using peptone. These results demonstrate that electrohydrogenesis can be used to produce H(2) from proteins, and it can also be used as a method for treatment of protein-containing wastewaters.

  1. A systematic methodology for design of tailor-made blended products

    DEFF Research Database (Denmark)

    Yunus, Nor Alafiza Binti; Gernaey, Krist; Woodley, John;

    2014-01-01

    A systematic methodology for design of tailor-made blended products has been developed. In tailor-made blended products, one identifies the product needs and matches them by blending different chemicals. The systematic methodology has four main tasks. First, the design problem is defined...

  2. Nucleus-based product conceptualization - Part 2. Application in designing for use

    NARCIS (Netherlands)

    Van der Vegte, W.F.; Horváth, I.

    2003-01-01

    when products are being designed, especially in conceptual design where there is a multitude of options for the designer. This paper presents a methodology to generate resource-integrated models unifying representations of the product, the user and the environment based on nucleus modelling, which i

  3. 78 FR 58318 - Clinical Trial Design for Intravenous Fat Emulsion Products; Public Workshop

    Science.gov (United States)

    2013-09-23

    ... HUMAN SERVICES Food and Drug Administration Clinical Trial Design for Intravenous Fat Emulsion Products... ``Clinical Trial Design for Intravenous Fat Emulsion Products.'' This workshop will provide a forum to discuss trial design of clinical trials intended to support registration of intravenous fat...

  4. Integration of chemical product development, process design and operation based on a kilo-plant

    Institute of Scientific and Technical Information of China (English)

    QIAN Yu; WU Zhihui; JIANG Yanbin

    2006-01-01

    Presented in this paper is an integrated approach of computer-aided product development, process design and operation analysis based on a kilo-plant. The implemented kilo-plant, as a research platform to manufacture product in kilogram-scale, was designed especially for fine and specialty chemicals. The characteristics of product synthesis, process operation and product quality control are investigated coupled with computer-aided monitoring, online modeling, simulation and operation process optimization. In this way, chemical product discovery, process design and operation are integrated in a systematic approach, in the aim to respond to rapid changing marketplace demands to new products.

  5. Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging.

    Science.gov (United States)

    Sage, Peter T; Tan, Catherine L; Freeman, Gordon J; Haigis, Marcia; Sharpe, Arlene H

    2015-07-14

    Defective antibody production in aging is broadly attributed to immunosenescence. However, the precise immunological mechanisms remain unclear. Here, we demonstrate an increase in the ratio of inhibitory T follicular regulatory (TFR) cells to stimulatory T follicular helper (TFH) cells in aged mice. Aged TFH and TFR cells are phenotypically distinct from those in young mice, exhibiting increased programmed cell death protein-1 expression but decreased ICOS expression. Aged TFH cells exhibit defective antigen-specific responses, and programmed cell death protein-ligand 1 blockade can partially rescue TFH cell function. In contrast, young and aged TFR cells have similar suppressive capacity on a per-cell basis in vitro and in vivo. Together, these studies reveal mechanisms contributing to defective humoral immunity in aging: an increase in suppressive TFR cells combined with impaired function of aged TFH cells results in reduced T-cell-dependent antibody responses in aged mice.

  6. Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

    Directory of Open Access Journals (Sweden)

    Peter T. Sage

    2015-07-01

    Full Text Available Defective antibody production in aging is broadly attributed to immunosenescence. However, the precise immunological mechanisms remain unclear. Here, we demonstrate an increase in the ratio of inhibitory T follicular regulatory (TFR cells to stimulatory T follicular helper (TFH cells in aged mice. Aged TFH and TFR cells are phenotypically distinct from those in young mice, exhibiting increased programmed cell death protein-1 expression but decreased ICOS expression. Aged TFH cells exhibit defective antigen-specific responses, and programmed cell death protein-ligand 1 blockade can partially rescue TFH cell function. In contrast, young and aged TFR cells have similar suppressive capacity on a per-cell basis in vitro and in vivo. Together, these studies reveal mechanisms contributing to defective humoral immunity in aging: an increase in suppressive TFR cells combined with impaired function of aged TFH cells results in reduced T-cell-dependent antibody responses in aged mice.

  7. Production of Induced Pluripotent Stem Cells by Reprogramming of Blood Cells

    Directory of Open Access Journals (Sweden)

    Sadia Zia

    2011-06-01

    Full Text Available Blood cells are the simple, efficient and economical source for the production of induced pluripotent cells. The discovery of induced pluripotent cells was not novel; it was pedestal on the scientific principals and technologies which have been developed over last six decades. These are nuclear transfer and the cloning of Animals, Pluripotent cell lines and fusion hybrids and Transcription Factors and lineage switching. The use of human embryonic stem cells in regenerative medicines was a breakthrough but make use of these cells arise ethical issues as they are obtained from human embryos. An alternative advancement using induced pluripotent stem cells, which mimics the embryonic stem cells has the significant gain that they replaced the embryonic stem cells. The pluripotent cells can be induced from terminally differentiated somatic cells by the Induction of only four defined factors including c-Myc, klf4, Oct4 and Sox2 which are enough to alter the fate of cell.

  8. Project design of the ultra pure water for solar cell production%浅谈太阳能电池生产用超纯水的工程设计

    Institute of Scientific and Technical Information of China (English)

    陈旭; 顾小红; 赵军; 倪明; 徐志清

    2015-01-01

    One Yixing solar cel production plant use the municipal tap-water as ultra pure water for solar cel production. The project by ultrafiltration ( UF) ,reverse osmosis ( RO) and electric desalination ( EDI) based ful membrane process,the operation 3 years indicate that,the system performance is stable,the water quality was greatly superior to solar cel production water quality standard,can reach the standard of ultra pure water.%宜兴某太阳能电池生产厂以市政自来水作为太阳能电池生产用的纯水水源,该工程以超滤( UF )、反渗透( RO)和电除盐( EDI)的全膜法工艺为主,投产运行3年的结果表明,系统性能稳定,出水水质大大优于太阳能电池生产用水水质标准,可达到超纯水水质标准。

  9. The Creative Design Research of Product Appearance Based on Human-machine Interaction and Interface

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Today's product creative design has rendered many fe atures and has brought a great change in our everyday life, there are many new c hallenges in its traditional theory and principle. According to the traditional design theory, the FBS design model pays more attention to the function and stru cture of the product. But this model still couldn't strengthen the relation bet ween product appearance design and human-machine design effectively. This paper adopt converse design thinking and presents an improve...

  10. The CMS Monte Carlo Production System: Development and Design

    Energy Technology Data Exchange (ETDEWEB)

    Evans, D. [Fermi National Accelerator Laboratory, Batavia, IL (United States)], E-mail: evansde@fnal.gov; Fanfani, A. [Universita degli Studi di Bologna and INFN Sezione di Bologna, Bologna (Italy); Kavka, C. [INFN Sezione di Trieste, Trieste (Italy); Lingen, F. van [California Institute of Technology, Pasadena, CA (United States); Eulisse, G. [Northeastern University, Boston, MA (United States); Bacchi, W.; Codispoti, G. [Universita degli Studi di Bologna and INFN Sezione di Bologna, Bologna (Italy); Mason, D. [Fermi National Accelerator Laboratory, Batavia, IL (United States); De Filippis, N. [INFN Sezione di Bari, Bari (Italy); Hernandez, J.M. [Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Madrid (Spain); Elmer, P. [Princeton University, Princeton, NJ (United States)

    2008-03-15

    The CMS production system has undergone a major architectural upgrade from its predecessor, with the goal of reducing the operational manpower needed and preparing for the large scale production required by the CMS physics plan. The new production system is a tiered architecture that facilitates robust and distributed production request processing and takes advantage of the multiple Grid and farm resources available to the CMS experiment.

  11. The CMS Monte Carlo Production System Development and Design

    CERN Document Server

    Evans, D; Kavka, C; Van Lingen, F; Eulisse, G; Bacchi, W; Codispoti, G; Mason, D; De Filippis, N; Hernandez J M; Elmer, P

    2008-01-01

    The CMS production system has undergone a major architectural upgrade from its predecessor, with the goal of reducing the operational manpower needed and preparing for the large scale production required by the CMS physics plan. The new production system is a tiered architecture that facilitates robust and distributed production request processing and takes advantage of the multiple Grid and farm resources available to the CMS experiment.

  12. Product Knowledge Representation and Integration Technology in Web-based Collaborative Design

    Institute of Scientific and Technical Information of China (English)

    HAO Wentao; TIAN Ling; LUO Wei; TONG Bingshu

    2006-01-01

    Because of the complexity of modern product design, the web-based collaborative product design aroused considerable attention of manufacturers in the last few years with the development of Internet technology. But it is still hardly achievable due to the difficulty to share product knowledge from different designers and systems. In this paper, we firstly create an ontology-based product model, which consists of PPR (Product, Process and Resource) concept models and PPR characteristic models, to describe product knowledge. Afterwards, how to represent the model in XML is discussed in detail. Then the mechanism of product knowledge collection and integration from different application systems based on interface agents is introduced. At last, a web-based open-architecture product knowledge integrating and sharing prototype system AD-HUB is developed. An example is also given and it shows that the theory discussed in this paper is efficient to represent and integrate product knowledge in web-based collaborative design processes.

  13. Statistical optimisation of cell growth and carotenoid production by Rhodotorula mucilaginosa

    Directory of Open Access Journals (Sweden)

    Iriani R. Maldonade

    2012-03-01

    Full Text Available Sequential statistical methods were used to maximise carotenoid production by a strain of Rhodotorula mucilaginosa, isolated from the Brazilian ecosystem. Initially, a factorial 2(5-1 experimental design was used, and the variables were pH and the levels of glucose, yeast extract, MgSO4.7H2O and KH2PO4. The nitrogen source (yeast extract was the most important variable in enhancing carotenoid production; MgSO4.7H2O and KH2PO4 had a negative influence. The initial pH had no significant effect on carotenoid and cell productions. We further investigated the effects of glucose and yeast extract effects, using a second-order central composite design (CCD to optimise carotenoid production, which was adequately approximated with a full quadratic equation obtained from a two-factor-2-level design. The analysis of quadratic surfaces showed that after 5 days of cultivation at 25ºC, the maximum carotenoid concentration (745 µg l-1 was obtained with 15 g l-1 of yeast extract and 20 g l-1 of glucose. The maximum carotenoid production (152 µg g-1 was obtained with 5 g l-1 yeast extract and 10 g l-1 glucose. Carotenoid formation was more sensitive to changes in yeast extract concentration than to changes in glucose concentration. Maximum cell production was achieved with 15-17 g l-1 of yeast extract and 15-20 g l-1 of glucose.

  14. Statistical optimisation of cell growth and carotenoid production by rhodotorula mucilaginosa.

    Science.gov (United States)

    Maldonade, Iriani R; Rodriguez-Amaya, Delia B; Scamparini, Adilma R P

    2012-01-01

    Sequential statistical methods were used to maximise carotenoid production by a strain of Rhodotorula mucilaginosa, isolated from the Brazilian ecosystem. Initially, a factorial 2(5-1) experimental design was used, and the variables were pH and the levels of glucose, yeast extract, MgSO4.7H2O and KH2PO4. The nitrogen source (yeast extract) was the most important variable in enhancing carotenoid production; MgSO4.7H2O and KH2PO4 had a negative influence. The initial pH had no significant effect on carotenoid and cell productions. We further investigated the effects of glucose and yeast extract effects, using a second-order central composite design (CCD) to optimise carotenoid production, which was adequately approximated with a full quadratic equation obtained from a two-factor-2-level design. The analysis of quadratic surfaces showed that after 5 days of cultivation at 25 °C, the maximum carotenoid concentration (745 µg l(-1)) was obtained with 15 g l(-1) of yeast extract and 20 g l(-1) of glucose. The maximum carotenoid production (152 µg g(-1)) was obtained with 5 g l(-1) yeast extract and 10 g l(-1) glucose. Carotenoid formation was more sensitive to changes in yeast extract concentration than to changes in glucose concentration. Maximum cell production was achieved with 15-17 g l(-1) of yeast extract and 15-20 g l(-1) of glucose.

  15. Ethanol Production from Biomass: Large Scale Facility Design Project

    Energy Technology Data Exchange (ETDEWEB)

    Berson, R. Eric [Univ. of Louisville, KY (United States)

    2009-10-29

    High solids processing of biomass slurries provides the following benefits: maximized product concentration in the fermentable sugar stream, reduced water usage, and reduced reactor size. However, high solids processing poses mixing and heat transfer problems above about 15% for pretreated corn stover solids due to their high viscosities. Also, highly viscous slurries require high power consumption in conventional stirred tanks since they must be run at high rotational speeds to maintain proper mixing. An 8 liter scraped surface bio-reactor (SSBR) is employed here that is designed to efficiently handle high solids loadings for enzymatic saccharification of pretreated corn stover (PCS) while maintaining power requirements on the order of low viscous liquids in conventional stirred tanks. Saccharification of biomass exhibit slow reaction rates and incomplete conversion, which may be attributed to enzyme deactivation and loss of activity due to a variety of mechanisms. Enzyme deactivation is classified into two categories here: one, deactivation due to enzyme-substrate interactions and two, deactivation due to all other factors that are grouped together and termed “non-specific” deactivation. A study was conducted to investigate the relative extents of “non-specific” deactivation and deactivation due to “enzyme-substrate interactions” and a model was developed that describes the kinetics of cellulose hydrolysis by considering the observed deactivation effects. Enzyme substrate interactions had a much more significant effect on overall deactivation with a deactivation rate constant about 20X higher than the non-specific deactivation rate constant (0.35 h-1 vs 0.018 h-1). The model is well validated by the experimental data and predicts complete conversion of cellulose within 30 hours in the absence of enzyme substrate interactions.

  16. Consumer-product attachment: measurement and design implications

    NARCIS (Netherlands)

    Schifferstein, H.N.J.; Zwartkruis-Pelgrim, E.P.H.

    2008-01-01

    Due to differences in the attachment consumers experience towards the durable products they own, they hang on to certain products whereas they easily dispose of others. From the viewpoint of sustainability, it may be worthwhile to lengthen the life span of many durable consumer products. Hence, ther

  17. Stress analysis for wall structure in mobile hot cell design

    Energy Technology Data Exchange (ETDEWEB)

    Bahrin, Muhammad Hannan, E-mail: hannan@nuclearmalaysia.gov.my; Rahman, Anwar Abdul, E-mail: anwar@nuclearmalaysia.gov.my; Hamzah, Mohd Arif, E-mail: arif@nuclearmalaysia.gov.my; Mamat, Mohd Rizal; Azman, Azraf; Hasan, Hasni [Prototype and Plant Development Centre, Technical Services Division, Malaysian Nuclear Agency (Malaysia)

    2016-01-22

    Malaysian Nuclear Agency is developing a Mobile Hot Cell (MHC) in order to handle and manage Spent High Activity Radioactive Sources (SHARS) such as teletherapy heads and irradiators. At present, there are only two units of MHC in the world, in South Africa and China. Malaysian Mobile Hot cell is developed by Malaysian Nuclear Agency with the assistance of IAEA expert, based on the design of South Africa and China, but with improved features. Stress analysis has been performed on the design in order to fulfil the safety requirement in operation of MHC. This paper discusses the loading analysis effect from the sand to the MHC wall structure.

  18. A Case Retrieval Projection Pursuit Model for Configuration Design of a Product Family%A Case Retrieval Projection Pursuit Model for Configuration Design of a Product Family

    Institute of Scientific and Technical Information of China (English)

    XU Zi-rong; ZHANG Yi-fei

    2011-01-01

    The paper studies on case-based reasoning of uncertain product attributes in configuration design of a product family. Interval numbers characterize uncertain product attributes. By interpolating a number of certain values randomly to replace interval numbers and making projection pursuit analysis on source cases and target cases of expanded numbers, we can get a projection value in the optimal projection direction. Based on projection value, we can construct a case retrieval model of projection pursuit that can handle coexisting certain and uncertain product attributes. The application examples of chainsaw configuration design show that case retrieval is highly sensitive to reliable results.

  19. Optical Design of Dye-Sensitized Nanocrystalline Solar Cells

    Institute of Scientific and Technical Information of China (English)

    LIU Xi-Zhe; MENG Qing-Bo; GAO Chun-Xiao; XUE Bo-Fei; WANG Hong-Xia; CHEN Li-Quan; O.Sato; A.Fujishima

    2004-01-01

    In nanocrystalline dye-sensitized solar cells (DSSCs) the absorption of a large fraction of the incident solar radiation is important for achieving high efficiencies. We develop a model to include both the optical process and the electrochemical process. This model allows us to calculate the performance of the different optical designs (for example the different scattering layers and the different reflecting plane). It is found that appropriate optical designs can improve the performance of DSSCs greatly.

  20. Design and Fabrication of Nanodevice for Cell Interfacing

    Science.gov (United States)

    Chinnappan, Prema

    The goal of this thesis is to (a) design and fabricate a nanodevice that interface with cells and (b) optimize neuronal cell culturing protocol. The long term objective of this thesis is to perform intracellular electrical signal recording and stimulation of neuronal cells. To achieve this objective, a nanodevice with "Fin" shaped electrodes was designed that increases the electrode area and conductance so that it reduces the signal loss as shown in the case of traditional circular Nanopillar design. The overarching goal of neuroscience is to target and discover the relationships between the functional connectivity-map of neuronal circuits and their physiological or pathological functions. For recording large number of neurons, technologies such as gold mushroom-shaped microelectrodes (Hai et al.), vertical nanowire electrode arrays (VNEAs) (Robinson et al.) and nanoFET technology (Tian et al.) are currently under development. The gold mushroom-shaped electrodes in order of microns are invasive for smaller cells with no successful recording for long durations. The VNEAs show high electrode impedance which causes large signal loss. The nanoFET shows higher noise levels and the manipulation of a single nanotube to penetrate a single cell is very challenging. This thesis presents the design and fabrication of a "Fin" shaped nanoelectrode which seeks to overcome the restrictions between electrode impedance and electrode size. Compared to the 3x3 array of 200nm diameter nanowire electrodes, the "Fin" electrodes reduces the interfacial impedance. The fabrication was done in Silicon on insulator wafer with conducting lines and contact pads completely insulated by Silicon dioxide layer and gold coated nanofins. Nanofins of width 200 nm were fabricated using Focused Ion Beam (FIB) milling. Both high density and low density nanofins were optimized and cells were cultured over them. The optimization of cell culture, adherence and differentiation protocols were done to grow

  1. Comprehensive design of omnidirectional high-performance perovskite solar cells

    OpenAIRE

    Yutao Zhang; Yimin Xuan

    2016-01-01

    The comprehensive design approach is established with coupled optical-electrical simulation for perovskite-based solar cell, which emerged as one of the most promising competitors to silicon solar cell for its low-cost fabrication and high PCE. The selection of structured surface, effect of geometry parameters, incident angle-dependence and polarization-sensitivity are considered in the simulation. The optical modeling is performed via the finite-difference time-domain method whilst the elect...

  2. Hormone Production by Epithelial Cells of Human Thymus in vitro.

    Science.gov (United States)

    Yarilin, A. A.; Sharova, N. I.; Bulanova, E. C.; Kotchergina, N. I.; Mitin, A. N.; Kharchenko, T. Yu.; Arshinov, V. Yu.

    1996-12-01

    The conditions of hormone production by human thymic stromal cell line were studied. Human thymic stromal cells did not produce any hormones in 5-day monoculture. Co-cultivation of these cells with human thymocytes induced alpha1-thymosin and thymulin production increased to 4-5 days of co-cultivation. An increase in number of human thymic stromal cells and thymocyte elimination were observed in co-culture. The maximal stimulation of proliferation and hormone secretion by human thymic stromal cell was reached in their co-culturing with thymocytes at relative concentrations of 10(4) and 10(7) cells per ml. Thymocyte viability was important for inducing the stimulatory effect. The effect of viable cells could not be replaced by their supernatant. Stimulatory activity of CD4(-)CD8(-) and CD4(+)CD8(+) thymocytes was comparable, alpha1-thymosin and some of its synthetic fragments did not influence alpha1-thymosin synthesis or slightly inhibited it (in high concentrations). Synthetic peptide corresponding to C-terminal half of alpha1-thymosin molecule strongly enhanced production of this hormone.

  3. The Design of a Five-Cell Superconducting RF Module with a PBG Coupler Cell

    Energy Technology Data Exchange (ETDEWEB)

    Arsenyev, Sergey A [Los Alamos National Laboratory; Simakov, Evgenya I [Los Alamos National Laboratory

    2012-08-29

    We discuss the problem of incorporating a Photonic Band Gap (PBG) cell into a superconducting accelerating module of 5 cells designed for the operational frequency of 2.1 GHz. The reason for using a PBG cell is to provide a good accelerating mode confinement and good Higher Order Mode (HOM) suppression. PBG cell can potentially be used for placing HOM and fundamental mode couplers. However, because of the naturally higher ratio of the peak magnetic field to the accelerating field in the PBG cell, it should be designed to operate at a lower accelerating gradient than the other cells of the module. This ensures that the probability of quench in the PBG cell would be no higher than in other elliptical cells of the structure.

  4. Design of an energy-efficient CNFET Full Adder Cell

    Directory of Open Access Journals (Sweden)

    Arezoo Taeb

    2012-05-01

    Full Text Available In this paper by using the carbon nanotube field effect transistor (CNFET, which is a promising alternative for the MOSFET transistor, two novel energy-efficient Full Adders are proposed. The proposed Full Adders show full swing logic and strong output drivability. The first design uses eight transistors and nine capacitors and the second design utilizes three capacitors less than the first design. Simulations, carried out using HSPICE based on the Stanford University CNFET model at 0.6V and 0.9V supply voltages, demonstrate the efficiency of type proposed circuit parameters such as delay, power and power-delay product.

  5. Smart Product Design and Production Control for Effective Mass Customization in the Industry 4.0 Concept

    Directory of Open Access Journals (Sweden)

    Zawadzki Przemysław

    2016-09-01

    Full Text Available The paper presents a general concept of smart design and production control as key elements for efficient operation of a smart factory. The authors present various techniques that aid the design process of individualized products and organization of their production in the context of realization of the mass customization strategy, which allows a shortened time of development for a new product. Particular attention was paid to integration of additive manufacturing technologies and virtual reality techniques, which are a base of the so-called hybrid prototyping.

  6. Project Management and Coordination of Distributed Cooperative Product Design in a Virtual Enterprise

    Institute of Scientific and Technical Information of China (English)

    CAO Yan; ZHANG Ying-jie; ZHAO Ru-jia

    2004-01-01

    The architecture of project management of distributed concurrent product design in a virtual enterprise is put forward. The process of project management and its functions are presented. Product design process coordination is also discussed. First, based on the analysis of traditional project management, project management and coordination of distributed cooperative product design in the virtual enterprise is put forward. Then, aiming at the characteristics of a distributed concurrent product design process, the inherent rules and complex interrelations in product development are studied. Accordingly,the architecture of project management of distributed cooperative product design in a virtual enterprise is presented to adapt to distributed concurrent development of complex products. The main advantages of the architecture are also discussed. Finally, the emphasis is placed on the project management process.Its main functions are set forth, such as project definition, task decomposition and distribution, resource constraints and dynamic resource scheduling, process fusion, task scheduling and monitoring,project plan, cost and quality evaluation, etc.

  7. HYDROGEN PRODUCTION FOR FUEL CELLS VIA REFORMING COAL-DERIVED METHANOL

    Energy Technology Data Exchange (ETDEWEB)

    Paul A. Erickson

    2006-01-01

    Hydrogen can be produced from many feedstocks including coal. The objectives of this project are to establish and prove a hydrogen production pathway from coal-derived methanol for fuel cell applications. This progress report is the ninth report submitted to the DOE reporting on the status and progress made during the course of the project. This report covers the time period of October 1, 2005-December 31, 2005. This quarter saw progress in four areas. These areas are: (1) reformate purification, (2) heat transfer enhancement, (3) autothermal reforming coal-derived methanol degradation test; and (4) model development for fuel cell system integration. The project is on schedule and is now shifting towards the design of an integrated PEM fuel cell system capable of using the coal-derived product. This system includes a membrane clean up unit and a commercially available PEM fuel cell.

  8. Study and application on product design system orienting to optimal utilization of material resources

    Institute of Scientific and Technical Information of China (English)

    YAN Chun-ping; XIONG Hong-ju; CAO Hua-jun; LIU Fei

    2006-01-01

    Product design plays a decisive role in material resource consumption in manufacturing systems. So it is significant to study optimal utilization of material resources of manufacturing system from the perspective of product design. This paper firstly defines concept of product design, then after an analysis of design objectives the author proposes a target system of product design with three subsystems: structural system, functional system, and technical system. Finally, a product design system on Architectural Metal Structure Enterprises is developed and used in light of the great consumption of material resources in Metal Structure Enterprises. The system has got an obvious effect on improving comprehensive optimal using rate of material resources of enterprises, reducing design cycle, improving management of enterprises.

  9. Design of a Simple and Cheap Water Electrolyser for the Production of Solar Hydrogen

    Directory of Open Access Journals (Sweden)

    Ram Prasad

    2009-06-01

    Full Text Available Commercially available conventional alkaline electrolyser and advanced polymer membrane electrolysers for water electrolysis are quite expensive. Taking into account this aspect, a very simple and cheap water electrolyser has been designed and fabricated utilising easily available economical materials for small scale production of hydrogen using renewable energy from photovoltaic panel. The construction details of the electrolyser with a schematic drawing of the experimental set-up for PV production of H2 are given. In order to fabricate the compact electrolyser, two coaxial tubular PVC pipes were used. The lower part of the inner pipe has fine perforations for the transport of ions through electrolyte between the electrodes. Two cylindrical electrodes, cathode and anode are kept in inner and outer pipes respectively. The performance of hydrogen production was measured using a photovoltaic panel directly connected to the electrolyser under atmospheric pressure and in 27wt% KOH solution. Flow rates of hydrogen and oxygen were measured using a digital flow meter. High purity fuel cell grade hydrogen (99.98% and oxygen (99.85% have been produced. The experimental results confirm that the present electrolyser has eligible properties for hydrogen production in remote areas. No such electrolyser has been reported prior to this work. Copyright (c 2009 by BCREC. All rights reserved.[Received: 20 May 2009, Revised: 14 August 2009, Accepted: 19 August 2009][How to Cite: R. Prasad. (2009. Design of a Simple and Cheap Water Electrolyser for the Production of Solar Hydrogen. Bulletin of Chemical Reaction Engineering and Catalysis, 4(1: 10-15.  doi:10.9767/bcrec.4.1.7113.10-15][How to Link/ DOI: http://dx.doi.org/10.9767/bcrec.4.1.7113.10-15 || or local: http://ejournal.undip.ac.id/index.php/bcrec/article/view/7113 ] 

  10. Design of a Simple and Cheap Water Electrolyser for the Production of Solar Hydrogen

    Directory of Open Access Journals (Sweden)

    R. Prasad

    2009-06-01

    Full Text Available Commercially available conventional alkaline electrolyser and advanced polymer membrane electrolysers for water electrolysis are quite expensive. Taking into account this aspect, a very simple and cheap water electrolyser has been designed and fabricated utilising easily available economical materials for small scale production of hydrogen using renewable energy from photovoltaic panel. The construction details of the electrolyser with a schematic drawing of the experimental set-up for PV production of H2 are given. In order to fabricate the compact electrolyser, two coaxial tubular PVC pipes were used. The lower part of the inner pipe has fine perforations for the transport of ions through electrolyte between the electrodes. Two cylindrical electrodes, cathode and anode are kept in inner and outer pipes respectively. The performance of hydrogen production was measured using a photovoltaic panel directly connected to the electrolyser under atmospheric pressure and in 27wt% KOH solution. Flow rates of hydrogen and oxygen were measured using a digital flow meter. High purity fuel cell grade hydrogen (99.98% and oxygen (99.85% have been produced. The experimental results confirm that the present electrolyser has eligible properties for hydrogen production in remote areas. No such electrolyser has been reported prior to this work. Copyright (c 2009 by BCREC. All rights reserved.[Received: 20 May 2009, Revised: 14 August 2009, Accepted: 19 August 2009][How to Cite: R. Prasad. (2009. Design of a Simple and Cheap Water Electrolyser for the Production of Solar Hydrogen. Bulletin of Chemical Reaction Engineering and Catalysis, 4(1: 10-15. doi:10.9767/bcrec.4.1.21.10-15][How to Link/ DOI: http://dx.doi.org/10.9767/bcrec.4.1.21.10-15

  11. Gene Delivery into Plant Cells for Recombinant Protein Production

    OpenAIRE

    Qiang Chen; Huafang Lai

    2015-01-01

    Recombinant proteins are primarily produced from cultures of mammalian, insect, and bacteria cells. In recent years, the development of deconstructed virus-based vectors has allowed plants to become a viable platform for recombinant protein production, with advantages in versatility, speed, cost, scalability, and safety over the current production paradigms. In this paper, we review the recent progress in the methodology of agroinfiltration, a solution to overcome the challenge of transgene d...

  12. A New Consumerism: The influence of social technologies on product design

    OpenAIRE

    De Vere, I

    2014-01-01

    Social media has enabled a new style of consumerism. Consumers are no longer passive recipients; instead they are assuming active and participatory roles in product design and production, facilitated by interaction and collaboration in virtual communities. This new participatory culture is blurring the boundaries between the specific roles of designer, consumer and producer, creating entrepreneurial opportunities for designers, and empowering consumers to influence product strategies. Evolvin...

  13. Virus-free transient protein production in Sf9 cells.

    Science.gov (United States)

    Shen, Xiao; Hacker, David L; Baldi, Lucia; Wurm, Florian M

    2014-02-10

    A method for virus-free transient gene expression from suspension-adapted Sf9 insect cells was developed with the gene of interest being expressed from a plasmid carrying the homologous region 5 enhancer (hr5) and the immediate early 1 (ie1) promoter from Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV). Under the optimal conditions described in the study, cells were transfected at a density of 30×10⁶ cells/mL with 0.9 μg DNA and 1.35 μg of linear 25 kD polyethylenimine (PEI) per million cells. Following transfection, the culture was diluted to 4×10⁶ cells/mL for the protein production phase. The volumetric yield of tumor necrosis factor receptor (ectodomain) fused to an Fc domain (TNFR-Fc) was about 100 μg/mL for cultures at volumes up to 300 mL. As expected, the molecular weight of the dimeric TNFR-Fc produced from Sf9 cells was about 6 kDa less than that produced from a recombinant Chinese hamster ovary (CHO) cell line due to differences in glycosylation between the two hosts. Transient transfection provides an alternative to the baculovirus expression vector system (BEVS) for the rapid production of recombinant proteins from Sf9 cells.

  14. Product Form Design Model Based on Multiobjective Optimization and Multicriteria Decision-Making

    Directory of Open Access Journals (Sweden)

    Meng-Dar Shieh

    2017-01-01

    Full Text Available Affective responses concern customers’ affective needs and have received increasing attention in consumer-focused research. To design a product that appeals to consumers, designers should consider multiple affective responses (MARs. Designing products capable of satisfying MARs falls into the category of multiobjective optimization (MOO. However, when exploring optimal product form design, most relevant studies have transformed multiple objectives into a single objective, which limits their usefulness to designers and consumers. To optimize product form design for MARs, this paper proposes an integrated model based on MOO and multicriteria decision-making (MCDM. First, design analysis is applied to identify design variables and MARs; quantification theory type I is then employed to build the relationship models between them; on the basis of these models, an MOO model for optimization of product form design is constructed. Next, we use nondominated sorting genetic algorithm-II (NSGA-II as a multiobjective evolutionary algorithm (MOEA to solve the MOO model and thereby derive Pareto optimal solutions. Finally, we adopt the fuzzy analytic hierarchy process (FAHP to obtain the optimal design from the Pareto solutions. A case study of car form design is conducted to demonstrate the proposed approach. The results suggest that this approach is feasible and effective in obtaining optimal designs and can provide great insight for product form design.

  15. The X-linked F cell production locus: Genetic mapping and role in fetal hemoglobin production

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y.C.; Smith, K.D.; Moore, R.D. [John Hopkins Univ., Baltimore, MD (United States)] [and others

    1994-09-01

    Postnatal fetal hemoglobin (Hb F) production is confined to a subset of erythocytes termed F-cells. There is a 10-20 fold variation in F-cell production in sickle cell disease (SCD) and normal individuals. Most of the variation in F-cell production has been attributed to a diallelic (High, Low) X-linked gene, the F-cell production (FCP) locus that we recently mapped to Xp22.2-22.3 (LOD=4.56, theta=0.04). Using multiple regression analysis in 262 Jamaican SCD patients we determined the relative contribution of the FCP locus and other variables previously associated with variation in Hb F level (gender, age, beta-globin haplotypes, number of alpha-globin genes and the FCP locus phenotypes). When the FCP locus is in the regression model, the FCP locus alone accounts for approximately 40% of the variation in Hb F level while the contribution of age, alpha-globin gene number, and beta-globin haplotypes was insignificant. When individuals with High FCP allele are removed from the analysis, the beta globin haplotype now contribute to >10% of the Hb F variation. We conclude that the X-linked FCP locus is the major determinant of all known variables in Hb F production. Using 4 highly polymorphic dinucleotide repeat markers that we identified from cosmids in Xp22.2-22.3, have localized the FCP locus to a 1 Mb minimal candidate region between DXS143 and DXS410.

  16. Multidisciplinary Product Decomposition and Analysis Based on Design Structure Matrix Modeling

    DEFF Research Database (Denmark)

    Habib, Tufail

    2014-01-01

    Design structure matrix (DSM) modeling in complex system design supports to define physical and logical configuration of subsystems, components, and their relationships. This modeling includes product decomposition, identification of interfaces, and structure analysis to increase the architectural...

  17. CONTEMPORARY USAGE OF TRADITIONAL TURKISH MOTIFS IN PRODUCT DESIGNS

    Directory of Open Access Journals (Sweden)

    Tulay Gumuser

    2012-12-01

    Full Text Available The aim of this study is to identify the traditional Turkish motifs and its relations among present industrial designs. Traditional Turkish motifs played a very important role in 16th century onwards. The arts of the Ottoman Empire were used because of their symbolic meanings and unique styles. When we examine these motifs we encounter; Tiger Stripe, Three Spot (Çintemani, Rumi, Hatayi, Penç, Cloud, Crescent, Star, Crown, Hyacinth, Tulip and Carnation motifs. Nowadays, Turkish designers have begun to use these traditional Turkish motifs in their designs so as to create differences and awareness in the world design. The examples of these industrial designs, using the Turkish motifs, have survived and have Ottoman heritage and historical value. In this study, the Turkish motifs will be examined along with their focus on contemporary Turkish industrial designs used today.

  18. Hybrid optimization and simulation to design a logistics network for distributing perishable products

    NARCIS (Netherlands)

    Keizer, de M.; Haijema, R.; Bloemhof-Ruwaard, J.M.; Vorst, van der J.G.A.J.

    2015-01-01

    Dynamics in product quality complicate the design of logistics networks for perishable products, like flowers and other agricultural products. Complications especially arise when multiple products from different origins have to come together for processes like bundling. This paper presents a new MIL

  19. Production design as a storytelling tool in the writing of Danish TV drama series The Legacy

    DEFF Research Database (Denmark)

    Redvall, Eva Novrup; Sabroe, Iben Albinus

    2016-01-01

    a script’ in order to execute a text. This article argues that the production designer can play a crucial part in the screenwriting process by contributing to the narrative and character design from an early stage. Focusing on the use of production design in the development, writing and production...... the production design perform crucial back story and character information related to the inheritance drama and to the portrayal of the artist matriarch Veronika who was intended to haunt the lives of her children throughout the series even though she dies in the very first episode....

  20. Fuel Cell Car Design Project for Freshman Engineering Courses

    Science.gov (United States)

    Duke, Steve R.; Davis, Virginia A.

    2014-01-01

    In the Samuel Ginn College of Engineering at Auburn University, we have integrated a semester long design project based on a toy fuel cell car into our freshman "Introduction to Chemical Engineering Class." The project provides the students a basic foundation in chemical reactions, energy, and dimensional analysis that facilitates…