WorldWideScience

Sample records for cell enlargement

  1. Enlargement

    OpenAIRE

    Dakowska, Dorota

    2015-01-01

    Addressing the enlargement of the European Union (EU) with a focus on its actors raises two main analytical challenges. The first relates to the premise that this process is more than a chronology and a set of procedures and instruments. This entails treating the enlargement not only as a technical process but also as a social process involving complex power relations. The second challenge lies in defining who the actors of the enlargement are.

  2. Assembly and enlargement of the primary cell wall in plants

    Science.gov (United States)

    Cosgrove, D. J.

    1997-01-01

    Growing plant cells are shaped by an extensible wall that is a complex amalgam of cellulose microfibrils bonded noncovalently to a matrix of hemicelluloses, pectins, and structural proteins. Cellulose is synthesized by complexes in the plasma membrane and is extruded as a self-assembling microfibril, whereas the matrix polymers are secreted by the Golgi apparatus and become integrated into the wall network by poorly understood mechanisms. The growing wall is under high tensile stress from cell turgor and is able to enlarge by a combination of stress relaxation and polymer creep. A pH-dependent mechanism of wall loosening, known as acid growth, is characteristic of growing walls and is mediated by a group of unusual wall proteins called expansins. Expansins appear to disrupt the noncovalent bonding of matrix hemicelluloses to the microfibril, thereby allowing the wall to yield to the mechanical forces generated by cell turgor. Other wall enzymes, such as (1-->4) beta-glucanases and pectinases, may make the wall more responsive to expansin-mediated wall creep whereas pectin methylesterases and peroxidases may alter the wall so as to make it resistant to expansin-mediated creep.

  3. Optimization of membrane stack configuration in enlarged microbial desalination cells for efficient water desalination

    Science.gov (United States)

    Chen, Xi; Sun, Haotian; Liang, Peng; Zhang, Xiaoyuan; Huang, Xia

    2016-08-01

    Microbial desalination cells are considered a low-energy-consumption, clean technology to simultaneously purify wastewater and desalinate saline water by utilizing the in situ energy source contained in wastewater. To enhance desalination performance and achieve an optimal membrane stack configuration, an enlarged stacked microbial desalination cell (SMDC) has been developed and tested with 6-14 desalination cells. The cross-membrane area of the enlarged SMDC is 100 cm2. The anode and cathode volumes are both 200 mL. To reduce internal resistance, the width of desalination cells is kept as <0.5 mm. The optimal configuration with 10 desalination cells achieves the highest total desalination rate (TDR) of 423 mg/h and the highest charge transfer efficiency (CTE) of 836% when treating the 20 g/L NaCl solution. During this process, the junction potential across membranes increases from 0 to 374 mV, and occupies up to 74% of the total potential loss inside the SMDC. This shows that the SMDC used in this work achieves the highest TDR and CTE among the reported studies, and the junction potential should be effectively controlled to achieve the desired desalination performance in future practical applications.

  4. Optimization of membrane stack configuration in enlarged microbial desalination cells for efficient water desalination

    Science.gov (United States)

    Chen, Xi; Sun, Haotian; Liang, Peng; Zhang, Xiaoyuan; Huang, Xia

    2016-08-01

    Microbial desalination cells are considered a low-energy-consumption, clean technology to simultaneously purify wastewater and desalinate saline water by utilizing the in situ energy source contained in wastewater. To enhance desalination performance and achieve an optimal membrane stack configuration, an enlarged stacked microbial desalination cell (SMDC) has been developed and tested with 6-14 desalination cells. The cross-membrane area of the enlarged SMDC is 100 cm2. The anode and cathode volumes are both 200 mL. To reduce internal resistance, the width of desalination cells is kept as cells achieves the highest total desalination rate (TDR) of 423 mg/h and the highest charge transfer efficiency (CTE) of 836% when treating the 20 g/L NaCl solution. During this process, the junction potential across membranes increases from 0 to 374 mV, and occupies up to 74% of the total potential loss inside the SMDC. This shows that the SMDC used in this work achieves the highest TDR and CTE among the reported studies, and the junction potential should be effectively controlled to achieve the desired desalination performance in future practical applications.

  5. Photophysical study on core-enlarged-rylendiimides and -anhydrides for dye sensitized solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Noelscher, Belinda; Meister, Michael; Howard, Ian; Battagliarin, Glauco; Li, Chen; Muellen, Klaus; Laquai, Frederic [Max-Planck-Institute for Polymer Research, Mainz (Germany)

    2011-07-01

    Dye Sensitized Solar Cells (DSSCs) are promising devices for light-weight and cheap photovoltaic energy conversion. Up to now many different dyes have been synthesized to improve the efficiency of these solar cells. Investigation of the relation between the photophysical properties of the dyes and their performance in solar cells is required for a better understanding of the working principle of DSSCs. In this contribution we present a photophysical study on novel core-enlarged perylene-iimides and -anhydrides. By changing the core size or expanding the bay-position the absorption maximum can be tuned and further shifted into the red part of the solar spectrum. We employ transient and steady-state photoinduced absorption as well as time-resolved photoluminescence spectroscopy to investigate the dynamics of charge generation and recombination of these dyes in solid-state DSSCs. Theoretically a higher efficiency of core-enlarged dyes due to increased photon harvesting can be expected, however, it appears that these dyes follow a different trend. Based on our results we draw conclusions for future material development of higher efficiency all-organic dyes for DSSCs.

  6. Lysosomal enlargement and lysosomal membrane destabilisation in mussel digestive cells measured by an integrative index

    International Nuclear Information System (INIS)

    Lysosomal responses (enlargement and membrane destabilisation) in mussel digestive cells are well-known environmental stress biomarkers in pollution effects monitoring in marine ecosystems. Presently, in laboratory and field studies, both responses were measured separately (in terms of lysosomal volume density - Vv - and labilisation period -LP) and combined (lysosomal response index - LRI) in order to contribute to their understanding and to develop an index useful for decisions makers. LRI integrates Vv and LP, which are not necessarily dependent lysosomal responses. It is unbiased and more sensitive than Vv and LP alone and diminishes background due to confounding factors. LRI provides a simple numerical index (consensus reference = 0; critical threshold = 1) directly related to the pollution impact degree. Moreover, LRI can be represented in a way that allows the interpretation of lysosomal responses, which is useful for environmental scientists. - Lysosomal responses to pollutants measured by an integrative index.

  7. MtgA Deletion-Triggered Cell Enlargement of Escherichia coli for Enhanced Intracellular Polyester Accumulation.

    Directory of Open Access Journals (Sweden)

    Ryosuke Kadoya

    Full Text Available Bacterial polyester polyhydroxyalkanoates (PHAs have been produced in engineered Escherichia coli, which turned into an efficient and versatile platform by applying metabolic and enzyme engineering approaches. The present study aimed at drawing out the latent potential of this organism using genome-wide mutagenesis. To meet this goal, a transposon-based mutagenesis was carried out on E. coli, which was transformed to produce poly(lactate-co-3-hydroxybutyrate from glucose. A high-throughput screening of polymer-accumulating cells on Nile red-containing plates isolated one mutant that produced 1.8-fold higher quantity of polymer without severe disadvantages in the cell growth and monomer composition of the polymer. The transposon was inserted into the locus within the gene encoding MtgA that takes part, as a non-lethal component, in the formation of the peptidoglycan backbone. Accordingly, the mtgA-deleted strain E. coli JW3175, which was a derivate of superior PHA-producing strain BW25113, was examined for polymer production, and exhibited an enhanced accumulation of the polymer (7.0 g/l compared to the control (5.2 g/l. Interestingly, an enlargement in cell width associated with polymer accumulation was observed in this strain, resulting in a 1.6-fold greater polymer accumulation per cell compared to the control. This result suggests that the increase in volumetric capacity for accumulating intracellular material contributed to the enhanced polymer production. The mtgA deletion should be combined with conventional engineering approaches, and thus, is a promising strategy for improved production of intracellularly accumulated biopolymers.

  8. Rapid enlargement of an intracranial germ cell tumor after gonadotropin hormone therapy.

    Science.gov (United States)

    Sasagawa, Yasuo; Tachibana, Osamu; Nakagawa, Athushi; Nakada, Satoko; Nojima, Takayuki; Koya, Daisuke; Iizuka, Hideaki

    2016-09-01

    We report a case of an intracranial germ cell tumor (iGCT) that showed rapid enlargement after human chorionic gonadotropin (hCG) hormone therapy for pituitary hypogonadism. A 16-year-old boy presented with headache and was diagnosed with a suprasellar tumor. He was initially observed without surgery. Intranasal desmopressin therapy was started for central diabetes insipidus, but there was no change in the tumor size on MRI. The diagnosis of the tumor remained unknown for 4years. Levels of serum gonadotropin hormones (follicle-stimulating and luteinizing hormone) and testosterone progressively decreased, and the patient developed pituitary hypogonadism and complained about his undeveloped beard, lack of underarm hair, and erectile dysfunction. Intramuscular gonadotropin injection (hCG 5000U×2/week) was started at age 20. Eight months after the first gonadotropin injection, the MRI showed tumor growth with vivid enhancement. Craniotomy was performed and the tumor was partially resected. The histological diagnosis was immature teratoma. After surgery, the patient was treated with 5 cycles of chemotherapy with carboplatin and etoposide. He also received radiation therapy of 50Gy (20Gy tumor bed and 30Gy whole ventricles) to the residual tumor, after which the tumor decreased in size. We postulate that iGCT may be at risk of progression during hCG hormone therapy. Thus, careful monitoring is required for a patient with iGCT who receives this therapy. PMID:27050912

  9. The enlarged lysosomes in beigej cells result from decreased lysosome fission and not increased lysosome fusion

    OpenAIRE

    Durchfort, Nina; Verhoef, Shane; Vaughn, Michael B.; Shrestha, Rishna; Adam, Dieter; Kaplan, Jerry; Ward, Diane McVey

    2011-01-01

    Chediak-Higashi Syndrome is an autosomal recessive disorder that affects vesicle morphology. The Chs1/Lyst protein is a member of the BEACH family of proteins. The absence of Chs1/Lyst gives rise to enlarged lysosomes. Lysosome size is regulated by a balance between vesicle fusion and fission and can be reversibly altered by acidifying the cytoplasm using Acetate Ringer’s or by incubating with the drug vacuolin-1. We took advantage of these procedures to determine rates of lysosome fusion and...

  10. Uniform stable conformal convolutional perfectly matched layer for enlarged cell technique conformal finite-difference time-domain method

    Institute of Scientific and Technical Information of China (English)

    王玥; 王建国; 陈再高

    2015-01-01

    Based on conformal construction of physical model in a three-dimensional Cartesian grid, integral-based confor-mal convolutional perfectly matched layer (CPML) is given for solving the truncation problem of the open port when the enlarged cell technique conformal finite-difference time-domain (ECT-CFDTD) method is used to simulate the wave propagation inside a perfect electric conductor (PEC) waveguide, and the algorithm has the same numerical stability as the ECT-CFDTD method. For the long-time propagation problems of evanescent wave in a waveguide, several numerical simulations are performed to analyze the reflection error by sweeping the constitutive parameters of the integral-based con-formal CPML. Numerical results show that the integral-based conformal CPML can be used for efficiently truncating the open port of the waveguide.

  11. Uniform stable conformal convolutional perfectly matched layer for enlarged cell technique conformal finite-difference time-domain method

    International Nuclear Information System (INIS)

    Based on conformal construction of physical model in a three-dimensional Cartesian grid, an integral-based conformal convolutional perfectly matched layer (CPML) is given for solving the truncation problem of the open port when the enlarged cell technique conformal finite-difference time-domain (ECT-CFDTD) method is used to simulate the wave propagation inside a perfect electric conductor (PEC) waveguide. The algorithm has the same numerical stability as the ECT-CFDTD method. For the long-time propagation problems of an evanescent wave in a waveguide, several numerical simulations are performed to analyze the reflection error by sweeping the constitutive parameters of the integral-based conformal CPML. Our numerical results show that the integral-based conformal CPML can be used to efficiently truncate the open port of the waveguide. (paper)

  12. Human serum activates CIDEB-mediated lipid droplet enlargement in hepatoma cells

    International Nuclear Information System (INIS)

    Highlights: •Human serum induced differentiation of hepatoma cells increases cellular lipid droplet (LD) size. •The observed increase in LD size correlates with increased PGC-1α and CIDEB expression. •Induction of CIDEB expression correlates with rescue of VLDL secretion and loss of ADRP. •siRNA knockdown of CIDEB impairs the human serum mediated increase in LD size. •This system represents a cost-efficient model to study CIDEB’s role in lipid biology. -- Abstract: Human hepatocytes constitutively express the lipid droplet (LD) associated protein cell death-inducing DFFA-like effector B (CIDEB). CIDEB mediates LD fusion, as well as very-low-density lipoprotein (VLDL) maturation. However, there are limited cell culture models readily available to study CIDEB’s role in these biological processes, as hepatoma cell lines express negligible levels of CIDEB. Recent work has highlighted the ability of human serum to differentiate hepatoma cells. Herein, we demonstrate that culturing Huh7.5 cells in media supplemented with human serum activates CIDEB expression. This activation occurs through the induced expression of PGC-1α, a positive transcriptional regulator of CIDEB. Coherent anti-Stokes Raman scattering (CARS) microscopy revealed a correlation between CIDEB levels and LD size in human serum treated Huh7.5 cells. Human serum treatment also resulted in a rapid decrease in the levels of adipose differentiation-related protein (ADRP). Furthermore, individual overexpression of CIDEB was sufficient to down-regulate ADRP protein levels. siRNA knockdown of CIDEB revealed that the human serum mediated increase in LD size was CIDEB-dependent. Overall, our work highlights CIDEB’s role in LD fusion, and presents a new model system to study the PGC-1α/CIDEB pathway’s role in LD dynamics and the VLDL pathway

  13. Peripheral T-Cell lymphoma manifested as gingival enlargement in a patient with chronic lymphocytic leukemia

    OpenAIRE

    Buddula, Aravind; Assad, Daniel

    2011-01-01

    Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in adults and is associated with increased risk of malignancy. T-cell lymphoma associated with CLL has never been reported. The case report presents a unique case of peripheral T-cell lymphoma on the gingiva of a patient with CLL. A 66-year-old man with a history of CLL was referred to the Mayo Clinic, Department of Dental Specialties, for evaluation of swelling in the upper left posterior sextant. An intraoral examination...

  14. Eastern Enlargement and Portugal

    OpenAIRE

    Tania Fernandes

    1999-01-01

    The paper is structured in two parts. The first one analyses the proposals of the European Commission concerning the reform of the European Union policies and the Eastern enlargement, set out in Agenda 2000. The second addresses the impacts of the Eastern enlargement to Portugal. The paper reviews the standard argument against the Eastern enlargement and presents evidence that an once and for all enlargement of all the ten Central and Eastern European Countries that applied for EU membership ...

  15. Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells

    Directory of Open Access Journals (Sweden)

    Hammarstedt Ann

    2012-09-01

    Full Text Available Abstract Background Obesity contributes to Type 2 diabetes by promoting systemic insulin resistance. Obesity causes features of metabolic dysfunction in the adipose tissue that may contribute to later impairments of insulin action in skeletal muscle and liver; these include reduced insulin-stimulated glucose transport, reduced expression of GLUT4, altered expression of adipokines, and adipocyte hypertrophy. Animal studies have shown that expansion of adipose tissue alone is not sufficient to cause systemic insulin resistance in the absence of adipose tissue metabolic dysfunction. To determine if this holds true for humans, we studied the relationship between insulin resistance and markers of adipose tissue dysfunction in non-obese individuals. Method 32 non-obese first-degree relatives of Type 2 diabetic patients were recruited. Glucose tolerance was determined by an oral glucose tolerance test and insulin sensitivity was measured with the hyperinsulinaemic-euglycaemic clamp. Blood samples were collected and subcutaneous abdominal adipose tissue biopsies obtained for gene/protein expression and adipocyte cell size measurements. Results Our findings show that also in non-obese individuals low insulin sensitivity is associated with signs of adipose tissue metabolic dysfunction characterized by low expression of GLUT4, altered adipokine profile and enlarged adipocyte cell size. In this group, insulin sensitivity is positively correlated to GLUT4 mRNA (R = 0.49, p = 0.011 and protein (R = 0.51, p = 0.004 expression, as well as with circulating adiponectin levels (R = 0.46, 0 = 0.009. In addition, insulin sensitivity is inversely correlated to circulating RBP4 (R = −0.61, 0 = 0.003 and adipocyte cell size (R = −0.40, p = 0.022. Furthermore, these features are inter-correlated and also associated with other clinical features of the metabolic syndrome in the absence of obesity. No association could be found

  16. EU enlargement and immigration

    OpenAIRE

    Kraus, Margit; Schwager, Robert

    2000-01-01

    This paper assesses the consequences of EU enlargement for East West migration. In the theoretical part, we identify several factors in addition to the reduction of moving costs by which EU membership influences migration. Specifically, EU accession affects income gaps. Moreover, if EU membership is refused, fear of future restrictions on immigration will lead to increased current migration. Additionally, casual evidence from the 1980s EU South enlargement is examined. Since then no increases...

  17. Effect of gamma radiation on resting B lymphocytes. I. Oxygen-dependent damage to the plasma membrane results in increased permeability and cell enlargement

    International Nuclear Information System (INIS)

    Although the susceptibility of resting B lymphocytes to radiation-induced interphase death is well known, the mechanism by which this occurs is not understood. In this report, we use three measures of plasma membrane integrity (increase in cell volume, uptake of trypan blue, and release of 51Cr) to assess the effect of radiation on the resting B cell plasma membrane. The delivery of 500 to 1000 rad caused the majority of resting B cells to enlarge slightly, whereas 3000 rad caused virtually all of the cells to approximately double in size within 3 to 4 hr. Measurement of the release of 51Cr from resting B cells revealed a similar relationship between the dose of radiation and the loss of radioactive label. Trypan blue exclusion was also found to diminish as a function of radiation dose. An analysis of a variety of lymphoid cells suggested that sensitivity to the membrane damaging effects of gamma radiation was in the order of resting B cells greater than resting T cells greater than a long-term L3T4+ T cell clone greater than a B cell lymphoma. LPS-induced B cell blasts treated with 3000 rad were equivalent to 1000 rad-treated resting B cells. The effects of the gamma radiation could be ameliorated by excluding oxygen at the time of irradiation, or by adding the free radical scavenging agent cysteamine. These data are compatible with the hypothesis that gamma radiation results in damage to the plasma membrane of resting lymphocytes via the generation of highly reactive free radical species. This damage is reflected in a rapid increase in plasma membrane permeability and swelling of the cells, and may play a major role in causing interphase death

  18. Surviving mossy cells enlarge and receive more excitatory synaptic input in a mouse model of temporal lobe epilepsy.

    Science.gov (United States)

    Zhang, Wei; Thamattoor, Ajoy K; LeRoy, Christopher; Buckmaster, Paul S

    2015-05-01

    Numerous hypotheses of temporal lobe epileptogenesis have been proposed, and several involve hippocampal mossy cells. Building on previous hypotheses we sought to test the possibility that after epileptogenic injuries surviving mossy cells develop into super-connected seizure-generating hub cells. If so, they might require more cellular machinery and consequently have larger somata, elongate their dendrites to receive more synaptic input, and display higher frequencies of miniature excitatory synaptic currents (mEPSCs). To test these possibilities pilocarpine-treated mice were evaluated using GluR2-immunocytochemistry, whole-cell recording, and biocytin-labeling. Epileptic pilocarpine-treated mice displayed substantial loss of GluR2-positive hilar neurons. Somata of surviving neurons were 1.4-times larger than in controls. Biocytin-labeled mossy cells also were larger in epileptic mice, but dendritic length per cell was not significantly different. The average frequency of mEPSCs of mossy cells recorded in the presence of tetrodotoxin and bicuculline was 3.2-times higher in epileptic pilocarpine-treated mice as compared to controls. Other parameters of mEPSCs were similar in both groups. Average input resistance of mossy cells in epileptic mice was reduced to 63% of controls, which is consistent with larger somata and would tend to make surviving mossy cells less excitable. Other intrinsic physiological characteristics examined were similar in both groups. Increased excitatory synaptic input is consistent with the hypothesis that surviving mossy cells develop into aberrantly super-connected seizure-generating hub cells, and soma hypertrophy is indirectly consistent with the possibility of axon sprouting. However, no obvious evidence of hyperexcitable intrinsic physiology was found. Furthermore, similar hypertrophy and hyper-connectivity has been reported for other neuron types in the dentate gyrus, suggesting mossy cells are not unique in this regard. Thus

  19. Enlargements of filtrations and applications

    CERN Document Server

    Corcuera, J M

    2012-01-01

    In this paper we review some old and new results about the enlargement of filtrations problem, as well as their applications to credit risk and insider trading problems. The enlargement of filtrations problem consists in the study of conditions under which a semimartingale remains a semimartingale when the filtration is enlarged, and, in such a case, how to find the Doob-Meyer decomposition. Filtrations may be enlarged in different ways. In this paper we consider initial and progressive filtration enlargements made by random variables and processes. Keywords: Credit Risk, Insider Trading, Enlargement of Filtrations

  20. A Decrease in Ambient Temperature Induces Post-Mitotic Enlargement of Palisade Cells in North American Lake Cress.

    Directory of Open Access Journals (Sweden)

    Rumi Amano

    Full Text Available In order to maintain organs and structures at their appropriate sizes, multicellular organisms orchestrate cell proliferation and post-mitotic cell expansion during morphogenesis. Recent studies using Arabidopsis leaves have shown that compensation, which is defined as post-mitotic cell expansion induced by a decrease in the number of cells during lateral organ development, is one example of such orchestration. Some of the basic molecular mechanisms underlying compensation have been revealed by genetic and chimeric analyses. However, to date, compensation had been observed only in mutants, transgenics, and γ-ray-treated plants, and it was unclear whether it occurs in plants under natural conditions. Here, we illustrate that a shift in ambient temperature could induce compensation in Rorippa aquatica (Brassicaceae, a semi-aquatic plant found in North America. The results suggest that compensation is a universal phenomenon among angiosperms and that the mechanism underlying compensation is shared, in part, between Arabidopsis and R. aquatica.

  1. Dynamic Texture Enlargement

    Czech Academy of Sciences Publication Activity Database

    Haindl, Michal; Richtr, Radek

    Bratislava : ACM, Comenius University, 2013, s. 13-20. ISBN 978-80-223-3377-1. ISSN 1335-5694. [29th Spring conference on Computer Graphics (SCCG). Smolenice castle (SK), 01.05.2013-03.05.2013] R&D Projects: GA ČR GA102/08/0593; GA ČR GAP103/11/0335 Institutional support: RVO:67985556 Keywords : dynamic texture * texture enlargement * tile-based texture synthesis Subject RIV: BD - Theory of Information http://library.utia.cas.cz/separaty/2013/RO/haindl-0397609.pdf

  2. Suppressor Screen and Phenotype Analyses Revealed an Emerging Role of the Monofunctional Peroxisomal Enoyl-CoA Hydratase 2 in Compensated Cell Enlargement.

    Science.gov (United States)

    Katano, Mana; Takahashi, Kazuki; Hirano, Tomonari; Kazama, Yusuke; Abe, Tomoko; Tsukaya, Hirokazu; Ferjani, Ali

    2016-01-01

    Efficient use of seed nutrient reserves is crucial for germination and establishment of plant seedlings. Mobilizing seed oil reserves in Arabidopsis involves β-oxidation, the glyoxylate cycle, and gluconeogenesis, which provide essential energy and the carbon skeletons needed to sustain seedling growth until photoautotrophy is acquired. We demonstrated that H(+)-PPase activity is required for gluconeogenesis. Lack of H(+)-PPase in fugu5 mutants increases cytosolic pyrophosphate (PPi) levels, which partially reduces sucrose synthesis de novo and inhibits cell division. In contrast, post-mitotic cell expansion in cotyledons was unusually enhanced, a phenotype called compensation. Therefore, it appears that PPi inhibits several cellular functions, including cell cycling, to trigger compensated cell enlargement (CCE). Here, we mutagenized fugu5-1 seeds with (12)C(6+) heavy-ion irradiation and screened mutations that restrain CCE to gain insight into the genetic pathway(s) involved in CCE. We isolated A#3-1, in which cell size was severely reduced, but cell number remained similar to that of original fugu5-1. Moreover, cell number decreased in A#3-1 single mutant (A#3-1sm), similar to that of fugu5-1, but cell size was almost equal to that of the wild type. Surprisingly, A#3-1 mutation did not affect CCE in other compensation exhibiting mutant backgrounds, such as an3-4 and fugu2-1/fas1-6. Subsequent map-based cloning combined with genome sequencing and HRM curve analysis identified enoyl-CoA hydratase 2 (ECH2) as the causal gene of A#3-1. The above phenotypes were consistently observed in the ech2-1 allele and supplying sucrose restored the morphological and cellular phenotypes in fugu5-1, ech2-1, A#3-1sm, fugu5-1 ech2-1, and A#3-1; fugu5-1. Taken together, these results suggest that defects in either H(+)-PPase or ECH2 compromise cell proliferation due to defects in mobilizing seed storage lipids. In contrast, ECH2 alone likely promotes CCE during the post

  3. Suppressor screen and phenotype analyses revealed an emerging role of the Monofunctional peroxisomal enoyl-CoA hydratase 2 in compensated cell enlargement

    Directory of Open Access Journals (Sweden)

    Mana eKatano

    2016-02-01

    Full Text Available Efficient use of seed nutrient reserves is crucial for germination and establishment of plant seedlings. Mobilizing seed oil reserves in Arabidopsis involves β-oxidation, the glyoxylate cycle, and gluconeogenesis, which provide essential energy and the carbon skeletons needed to sustain seedling growth until photoautotrophy is acquired. We demonstrated that H+-PPase activity is required for gluconeogenesis. Lack of H+-PPase in fugu5 mutants increases cytosolic pyrophosphate (PPi levels, which partially reduces sucrose synthesis de novo and inhibits cell division. In contrast, post-mitotic cell expansion in cotyledons was unusually enhanced, a phenotype called compensation. Therefore, it appears that PPi inhibits several cellular functions, including cell cycling, to trigger compensated cell enlargement (CCE. Here, we mutagenized fugu5-1 seeds with 12C6+ heavy-ion irradiation and screened mutations that restrain CCE to gain insight into the genetic pathway(s involved in CCE. We isolated A#3-1, in which cell size was severely reduced, but cell number remained similar to that of original fugu5-1. Moreover, cell number decreased in A#3-1 single mutant (A#3-1sm, similar to that of fugu5-1, but cell size was almost equal to that of the wild type. Surprisingly, A#3-1 mutation did not affect CCE in other compensation exhibiting mutant backgrounds, such as an3-4 and fugu2-1/fas1-6. Subsequent map-based cloning combined with genome sequencing and HRM curve analysis identified enoyl-CoA hydratase 2 (ECH2 as the causal gene of A#3-1. The above phenotypes were consistently observed in the ech2-1 allele and supplying sucrose restored the morphological and cellular phenotypes in fugu5-1, ech2-1, A#3-1sm, fugu5-1 ech2-1 and A#3-1;fugu5-1. Taken together, these results suggest that defects in either H+-PPase or ECH2 compromise cell proliferation due to defects in mobilizing stored lipids. In contrast, ECH2 alone likely promotes CCE during the post-mitotic cell

  4. Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus.

    Science.gov (United States)

    Kitahara, Yosuke; Ohta, Keisuke; Hasuo, Hiroshi; Shuto, Takahide; Kuroiwa, Mahomi; Sotogaku, Naoki; Togo, Akinobu; Nakamura, Kei-ichiro; Nishi, Akinori

    2016-01-01

    A selective serotonin reuptake inhibitor is the most commonly prescribed antidepressant for the treatment of major depression. However, the mechanisms underlying the actions of selective serotonin reuptake inhibitors are not fully understood. In the dentate gyrus, chronic fluoxetine treatment induces increased excitability of mature granule cells (GCs) as well as neurogenesis. The major input to the dentate gyrus is the perforant path axons (boutons) from the entorhinal cortex (layer II). Through voltage-sensitive dye imaging, we found that the excitatory neurotransmission of the perforant path synapse onto the GCs in the middle molecular layer of the mouse dentate gyrus (perforant path-GC synapse) is enhanced after chronic fluoxetine treatment (15 mg/kg/day, 14 days). Therefore, we further examined whether chronic fluoxetine treatment affects the morphology of the perforant path-GC synapse, using FIB/SEM (focused ion beam/scanning electron microscopy). A three-dimensional reconstruction of dendritic spines revealed the appearance of extremely large-sized spines after chronic fluoxetine treatment. The large-sized spines had a postsynaptic density with a large volume. However, chronic fluoxetine treatment did not affect spine density. The presynaptic boutons that were in contact with the large-sized spines were large in volume, and the volumes of the mitochondria and synaptic vesicles inside the boutons were correlated with the size of the boutons. Thus, the large-sized perforant path-GC synapse induced by chronic fluoxetine treatment contains synaptic components that correlate with the synapse size and that may be involved in enhanced glutamatergic neurotransmission. PMID:26788851

  5. Methods of Enlarging English Vocabulary

    Institute of Scientific and Technical Information of China (English)

    丁小航

    2012-01-01

      In order to enlarge English vocabulary , we need to have some methods. I’d like to share my experience with begin⁃ners how I enlarge English vocabulary when when I am learning English. It is a long process and needs hard work and patience.

  6. Intratumoral Interleukin-21 Increases Antitumor Immunity, Tumor-infiltrating CD8(+) T-cell Density and Activity, and Enlarges Draining Lymph Nodes

    DEFF Research Database (Denmark)

    Sondergaard, H.; Galsgaard, E.D.; Bartholomaeussen, M.; Straten, P.T.; Odum, N.; Skak, K.

    2010-01-01

    that the increased efficacy of IT administration of IL-21 was due to a local rather than systemic effect. IT administration of IL-21 led to enlarged tumor-draining lymph nodes (LNs), with increased naive lymphocyte numbers and proliferation of activated lymphocytes, suggesting that local administration...

  7. AtPGL3 is an Arabidopsis BURP domain protein that is localized to the cell wall and promotes cell enlargement.

    Science.gov (United States)

    Park, Jiyoung; Cui, Yong; Kang, Byung-Ho

    2015-01-01

    The BURP domain is a plant-specific domain that has been identified in secretory proteins, and some of these are involved in cell wall modification. The tomato polygalacturonase I complex involved in pectin degradation in ripening fruits has a non-catalytic subunit that has a BURP domain. This protein is called polygalacturonase 1 beta (PG1β) and the Arabidopsis genome encodes three proteins that exhibit strong amino acid similarities with PG1β? We generated Arabidopsis lines in which expression levels of AtPGLs are altered in order to investigate the biological roles of the Arabidopsis PG1β-like proteins (AtPGLs). Among the three AtPGLs (AtPGL1-3), AtPGL3 exhibited the highest transcriptional activity throughout all developmental stages. AtPGL triple mutant plants have smaller rosette leaves than those of wild type plants because the leaf cells are smaller in the mutant plants. Interestingly, when we overexpressed AtPGL3 using a 35S promoter, leaf cells in transgenic plants grew larger than those of the wild type. A C-terminal GFP fusion protein of AtPGL3 complemented phenotypes of the triple mutant plants and it localized to the cell wall. A truncated AtPGL3-GFP fusion protein lacking the BURP domain failed to rescue the mutant phenotypes even though the GFP protein was targeted to the cell wall, indicating that the BURP domain is required for the protein's effect on cell expansion. Quantitative RT-PCR and immunoblot analyses indicated that the α-expansin 6 gene is up-regulated in the overexpressor plants. Taken together, these results indicate that AtPGL3 is an apoplastic BURP domain protein playing a role in cell expansion. PMID:26106400

  8. AtPGL3 is an Arabidopsis BURP domain protein that is localized to the cell wall and promotes cell enlargement

    OpenAIRE

    Park, Jiyoung; Cui, Yong; Kang, Byung-Ho

    2015-01-01

    The BURP domain is a plant-specific domain that has been identified in secretory proteins, and some of these are involved in cell wall modification. The tomato polygalacturonase I complex involved in pectin degradation in ripening fruits has a non-catalytic subunit that has a BURP domain. This protein is called polygalacturonase 1 beta (PG1β) and the Arabidopsis genome encodes three proteins that exhibit strong amino acid similarities with PG1β? We generated Arabidopsis lines in which express...

  9. Agriculture and European Union Enlargement

    OpenAIRE

    Josling, Tim; Kelch, David R.; Liapis, Peter S.; Tangerman, Stefan

    1998-01-01

    Potential accession of a number of eastern and central European countries into the European Union (EU) seems destined to lead to further reforms of the Common Agricultural Policy (CAP). The financial costs of absorbing these countries may be extreme. This report documents the modeling framework (European Simulation Model, ESIM) used to analyze the 1992 CAP reform and discusses possible effects of EU enlargement.

  10. Simultaneously improved capacity and initial coulombic efficiency of Li-rich cathode Li[Li0.2Mn0.54Co0.13Ni0.13]O2 by enlarging crystal cell from a nanoplate precursor

    Science.gov (United States)

    Dai, Dongmei; Li, Bao; Tang, Hongwei; Chang, Kun; Jiang, Kai; Chang, Zhaorong; Yuan, Xiaozi

    2016-03-01

    Li-rich manganese layered oxide is one of the most promising cathode materials that meet the requirements for high-energy-density Li-ion batteries. However, a large irreversible capacity loss at the first cycle makes it difficult to be an applicable cathode material. Although wide investigations have been carried out to overcome such defect, researchers are still beset by the problems of how to concurrently improve the multiple performances of the cathode. In this work, Li[Li0.2Mn0.54Co0.13Ni0.13]O2 is synthesized, which delivers both improved high-energy capacity of 308 mAh g-1 and enhanced initial coulombic efficiency of 85%. The corresponding values of a contrast sample are only 245 mAh g-1 and 77%, respectively. Based on the data of bond distances, crystal cell parameters, and the calculated electron cloud density revealed by Rietveld analysis, an enlarged crystal cell mechanism is proposed. The improved performances are originated from the enlarged crystal cell, which facilitates the Li+ delithiation/lithiation from the octahedral and tetrahedral sites, accordingly increasing the discharge capacity and initial coulombic efficiency. The proposed method offers a strategy to simultaneously increase the initial coulombic efficiency and the specific capacity for Li ion batteries.

  11. Enlarged Vestibular Aqueducts and Childhood Hearing Loss

    Science.gov (United States)

    ... Health Info » Hearing, Ear Infections, and Deafness Enlarged Vestibular Aqueducts and Childhood Hearing Loss On this page: ... more information about enlarged vestibular aqueducts? What are vestibular aqueducts? The inner ear Credit: NIH Medical Arts ...

  12. Imaging diagnosis of enlarged uterus

    International Nuclear Information System (INIS)

    We evaluated ultrasonographic and MRI findings of 24 histologically proven cases of enlarged uterus, which consisted of 19 cases of myoma uteri and 7 cases of adenomyosis. Preoperative diagnostic accuracy was 70% for ultrasonography , and 96% for MR imaging. In this retrospective study comparing with macroscopic specimens, there was no significant difference between myoma uteri and adenomyosis on sonographic appearances, while significant differences were observed on MRI in regard to the margin of the lesions, myometrial contour, and presence of internal high intensity spots. Furthermore, MR imaging reflected macroscopic appearance of specimens more accurately. However, there were some diagnostic pitfalls even on MR imaging. (author)

  13. Tuning of the temperature window for unit-cell and pore-size enlargement in face-centered-cubic large-mesopore silicas templated by swollen block copolymer micelles.

    Science.gov (United States)

    Li, Yingyu; Yi, Jinhui; Kruk, Michal

    2015-09-01

    The unit-cell size and pore diameter as functions of temperature are investigated in the syntheses of FDU-12 silicas with face-centered cubic structure templated by Pluronic (PEO-PPO-PEO) block copolymer micelles swollen by toluene. The temperature range in which the unit-cell size and pore size strongly increase as temperature decreases is correlated with the critical micelle temperature (CMT) of the surfactant. While Pluronic F127 affords a wide range of unit-cell parameters (28-51 nm) and pore diameters (16-32 nm), it renders moderately enlarged pore sizes at 25 °C. The use of Pluronic F108 with higher CMT affords FDU-12 with very large unit-cell size (∼49 nm) and large pore diameter (27 nm) at 23 °C. Large unit-cell size (40-41 nm) and pore size (22 nm) were obtained even at 25 °C. The application of Pluronics F87 and F88 with much smaller molecular weights and higher CMTs also allows one to synthesize FDU-12 with quite large unit-cell parameters and pore sizes at room temperature. The present work demonstrates that one can judiciously select Pluronic surfactants with appropriate CMT to shift the temperature range in which the pore diameter is readily tunable. PMID:26178137

  14. Intratumoral interleukin-21 increases antitumor immunity, tumor-infiltrating CD8+ T-cell density and activity, and enlarges draining lymph nodes

    DEFF Research Database (Denmark)

    Søndergaard, Henrik; Galsgaard, Elisabeth D; Bartholomaeussen, Monica;

    2010-01-01

    benefits the tumor microenvironment and activates tumor-draining LNs. Overall, our data suggest that IL-21 augments CD8 T-cell-mediated antitumor immunity through increased proliferation and effector function and acts both on tumor-infiltrating CD8 T cells as well as on the draining LNs. IT administration...

  15. Enlargement of the iliopsoas comportment

    International Nuclear Information System (INIS)

    The iliopsoas or iliopectineal comportment is a normal structure that occasionally communicates with the synovial cavity of the hip. Rarely, in association with certain pathologies that raise the intraarticular pressure, it becomes enlarged, producing an inguinal or pelvic mass, also referred to as iliopsas bursitis. We present five cases of this pathology detected over the past year in our hospitals. Three of the patients had undergone previous vascular punctures in the hip involved, one presented brucellosis-related arthropathy and the fifth had generative joint abnormalities. The plain radiography, arthrography, ultrasound, CT,CT-guided arthrography and MR images are provided and discussed. We present an etiological factor of this process (previous vascular puncture) that has not been previously reported in the literature. 13 refs

  16. The Fungal Defensin Family Enlarged

    Directory of Open Access Journals (Sweden)

    Jiajia Wu

    2014-08-01

    Full Text Available Fungi are an emerging source of peptide antibiotics. With the availability of a large number of model fungal genome sequences, we can expect that more and more fungal defensin-like peptides (fDLPs will be discovered by sequence similarity search. Here, we report a total of 69 new fDLPs encoded by 63 genes, in which a group of fDLPs derived from dermatophytes are defined as a new family (fDEF8 according to sequence and phylogenetic analyses. In the oleaginous fungus Mortierella alpine, fDLPs have undergone extensive gene expansion. Our work further enlarges the fungal defensin family and will help characterize new peptide antibiotics with therapeutic potential.

  17. Prenatal Exposure to Autism-Specific Maternal Autoantibodies Alters Proliferation of Cortical Neural Precursor Cells, Enlarges Brain, and Increases Neuronal Size in Adult Animals.

    Science.gov (United States)

    Martínez-Cerdeño, Verónica; Camacho, Jasmin; Fox, Elizabeth; Miller, Elaine; Ariza, Jeanelle; Kienzle, Devon; Plank, Kaela; Noctor, Stephen C; Van de Water, Judy

    2016-01-01

    Autism spectrum disorders (ASDs) affect up to 1 in 68 children. Autism-specific autoantibodies directed against fetal brain proteins have been found exclusively in a subpopulation of mothers whose children were diagnosed with ASD or maternal autoantibody-related autism. We tested the impact of autoantibodies on brain development in mice by transferring human antigen-specific IgG directly into the cerebral ventricles of embryonic mice during cortical neurogenesis. We show that autoantibodies recognize radial glial cells during development. We also show that prenatal exposure to autism-specific maternal autoantibodies increased stem cell proliferation in the subventricular zone (SVZ) of the embryonic neocortex, increased adult brain size and weight, and increased the size of adult cortical neurons. We propose that prenatal exposure to autism-specific maternal autoantibodies directly affects radial glial cell development and presents a viable pathologic mechanism for the maternal autoantibody-related prenatal ASD risk factor. PMID:25535268

  18. Acute exacerbation of airspace enlargement with fibrosis

    OpenAIRE

    Tomoyuki Kakugawa; Kazuhiro Tabata; Daiki Ogawara; Tomoshi Tsuchiya; Shintaro Hara; Noriho Sakamoto; Yuji Ishimatsu; Kazuto Ashizawa; Takeshi Nagayasu; Junya Fukuoka; Shigeru Kohno

    2014-01-01

    In 2008, Kawabata et al. described a lesion which they termed “airspace enlargement with fibrosis” that could be included on the spectrum of smoking-related interstitial lung diseases. This group also reported that patients with airspace enlargement with fibrosis but without coexisting interstitial pneumonia of another type had no acute exacerbations and favorable prognoses on clinical follow-up. Here we describe the first case, to our knowledge, of acute exacerbation of airspace enlargement ...

  19. EU enlargement and theories of economic integration

    OpenAIRE

    Susan Senior

    2010-01-01

    The fifth wave of EU enlargement taking place in 2004 and 2007 was the culmination of a long process beginning in 1989. Early on the Central and Eastern Europe countries began requesting membership, taking the then European Community by surprise. Only slowly during the 1990s were criteria for accession drawn up and empirical studies of the likely effects of enlargement began to emerge. The theoretical basis for analysis of the enlargement process was heterogeneous and piecemeal, and it is dif...

  20. The European Union's Eastward Enlargement

    Directory of Open Access Journals (Sweden)

    Hanns-D. Jacobsen

    1997-08-01

    Full Text Available In July 1997 the Commission of the European Union presented its Agenda 2000. This document not only suggested to start accession talks with some East and Central European countries (CEEC in early 1998 but it also provided proposals for a restructuring of EU expenditures. On this background this contribution discusses the state of readiness of the Central and East European countries to become EU members over the next few years and the Union's capacity to absorb up to ten CEEC over the next decade or so. This study concludes that the European Union has become an anchor of stability to the CEEC that guarantees both democracy and economic security--much more than could be expected only a couple of years ago. The Union's readiness to accept the membership of CEEC has, in a decisive way, contributed to their societal, political and economic stabilization. There is almost a contest among the CEEC on which one is going to meet the accession criteria first and best. The enlargement process, however, is connected to problems the resolution of which realistically postpone its successful conclusion at least into the year 2005. The main reasons are (1 the welfare gap between the EU area and the CEEC, (2 the need for more institutional and economic changes in the CEEC to make them ready for acces-sion, and, most importantly, (3 the necessity for the European Union to prepare herself for accession by a comprehensive financial reform and fundamental institutional changes.

  1. The "New Politics" of EU's Eastern Enlargement

    DEFF Research Database (Denmark)

    Zank, Wolfgang

    The paper gives an overview of EU's eastern enlargement and draws some theoretical conclusions. In particular, it stresses the point that the EU member states in the process of enlargement have entered a phase of "new politics", characterised by multilateralism, conditionality, help and binding a...

  2. Pseudoangiomatous stromal hyperplasia causing massive breast enlargement.

    Science.gov (United States)

    Bourke, Anita Geraldine; Tiang, Stephen; Harvey, Nathan; McClure, Robert

    2015-01-01

    Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign mesenchymal proliferative process, initially described by Vuitch et al. We report an unusual case of a 46-year-old woman who presented with a 6-week history of bilateral massive, asymmetrical, painful enlargement of her breasts, without a history of trauma. On clinical examination, both breasts were markedly enlarged and oedematous, but there were no discrete palpable masses. Preoperative image-guided core biopsies and surgery showed PASH. PASH is increasingly recognised as an incidental finding on image-guided core biopsy performed for screen detected lesions. There are a few reported cases of PASH presenting as rapid breast enlargement. In our case, the patient presented with painful, asymmetrical, massive breast enlargement. Awareness needs to be raised of this entity as a differential diagnosis in massive, painful breast enlargement. PMID:26475873

  3. Enhancement of Median Nerve Regeneration by Mesenchymal Stem Cells Engraftment in an Absorbable Conduit: Improvement of Peripheral Nerve Morphology with Enlargement of Somatosensory Cortical Representation.

    Directory of Open Access Journals (Sweden)

    Julia Teixeira Oliveira

    2014-10-01

    Full Text Available We studied the morphology and the cortical representation of the median nerve (MN, 10 weeks after a transection immediately followed by treatment with tubulization using a polycaprolactone (PCL conduit with or without bone marrow-derived mesenchymal stem cell (MSC transplant. In order to characterize the cutaneous representation of MN inputs in primary somatosensory cortex (S1, electrophysiological cortical mapping of the somatosensory representation of the forepaw and adjacent body parts was performed after acute lesion of all brachial plexus nerves, except for the MN. This was performed in ten adult male Wistar rats randomly assigned in 3 groups: MN Intact (n=4, PCL-Only (n=3 and PCL+MSC (n=3. Ten weeks before mapping procedures in animals from PCL-Only and PCL+MSC groups, animal were subjected to MN transection with removal of a 4-mm-long segment, immediately followed by suturing a PCL conduit to the nerve stumps with (PCL+MSC group or without (PCL-Only group injection of MSC into the conduit. After mapping the representation of the MN in S1, animals had a segment of the regenerated nerve processed for light and transmission electron microscopy. For histomorphometric analysis of the nerve segment, sample size was increased to 5 animals per experimental group. The PCL+MSC group presented a higher number of myelinated fibers and a larger cortical representation of MN inputs in S1 (3,383±390 fibers; 2.3 mm2, respectively than the PCL-Only group (2,226±575 fibers; 1.6 mm2. In conclusion, MSC-based therapy associated with PCL conduits can improve MN regeneration. This treatment seems to rescue the nerve representation in S1, thus minimizing the stabilization of new representations of adjacent body parts in regions previously responsive to the MN.

  4. Enlarged facial pores: an update on treatments.

    Science.gov (United States)

    Dong, Joanna; Lanoue, Julien; Goldenberg, Gary

    2016-07-01

    Enlarged facial pores remain a common dermatologic and cosmetic concern from acne and rosacea, among other conditions, that is difficult to treat due to the multifactorial nature of their pathogenesis and negative impact on patients' quality of life. Enlarged facial pores are primarily treated through addressing associative factors, such as increased sebum production and cutaneous aging. We review the current treatment modalities for enlarged or dense facial pores, including topical retinoids, chemical peels, oral antiandrogens, and lasers and devices, with a focus on newer therapies. PMID:27529707

  5. Hypertrophy, Tonsillar (Enlarged Tonsils) (For Parents)

    Science.gov (United States)

    ... For Kids For Parents MORE ON THIS TOPIC Mononucleosis Tonsils and Tonsillectomies Peritonsillar Abscess Strep Throat Tonsillitis ... on Strep Throat Enlarged Adenoids Tonsils and Tonsillectomies Mononucleosis Peritonsillar Abscess Strep Throat Tonsillitis Contact Us Print ...

  6. Electrocardiographically Determination of Cardiac Enlargements in Dogs

    OpenAIRE

    Gönül, Remzi; OR, Mehmet Erman; DODURKA, Tamer

    2002-01-01

    In this study, the electrocardiographic parameters necessary to determine cardiac enlargements and to establish and distinguish such complaints from each other in the early stage in dogs with circulatory problems were assessed. The material of the study consisted of 33 dogs 1.5-15 years of age with cardiac enlargements determined from 140 dogs suspected of having cardiac disease based on clinical, radiographic and electrocardiographic analyses. In these dogs, 12 cases of left atrial hypert...

  7. Acute exacerbation of airspace enlargement with fibrosis

    Directory of Open Access Journals (Sweden)

    Tomoyuki Kakugawa

    2014-01-01

    Full Text Available In 2008, Kawabata et al. described a lesion which they termed “airspace enlargement with fibrosis” that could be included on the spectrum of smoking-related interstitial lung diseases. This group also reported that patients with airspace enlargement with fibrosis but without coexisting interstitial pneumonia of another type had no acute exacerbations and favorable prognoses on clinical follow-up. Here we describe the first case, to our knowledge, of acute exacerbation of airspace enlargement with fibrosis without coexisting interstitial pneumonia of another type. An 82-year-old man was referred to our department for worsening dyspnea and new alveolar opacities on chest radiograph following left pulmonary segmentectomy (S6 for cancer. A diagnosis of acute exacerbation of airspace enlargement with fibrosis without coexisting interstitial pneumonia of other types was made, based on pathological evidence of airspace enlargement with fibrosis and organizing diffuse alveolar damage. Treatment with high-dose methylprednisolone followed by tapered oral prednisolone resulted in gradual improvement of the clinical condition and chest radiographic findings. Clinicians should be aware that patients with airspace enlargement with fibrosis may experience acute exacerbation.

  8. Acrolein Induces Endoplasmic Reticulum Stress and Causes Airspace Enlargement

    OpenAIRE

    Kitaguchi, Yoshiaki; Taraseviciene-Stewart, Laimute; Hanaoka, Masayuki; Natarajan, Ramesh; Kraskauskas, Donatas; Norbert F. Voelkel

    2012-01-01

    Background Given the relative abundance and toxic potential of acrolein in inhaled cigarette smoke, it is surprising how little is known about the pulmonary and systemic effects of acrolein. Here we test the hypothesis whether systemic administration of acrolein could cause endoplasmic reticulum (ER) stress, and lung cell apoptosis, leading to the enlargement of the alveolar air spaces in rats. Methods Acute and chronic effects of intraperitoneally administered acrolein were tested. Mean alve...

  9. Generalised Leukaemic Gingival Enlargement: a Case Report

    Directory of Open Access Journals (Sweden)

    Mechery Reenesh

    2012-09-01

    Full Text Available Background: Acute myeloblastic leukaemia is a malignant bone marrow neoplasm of myeloid precursors of white blood cells. Due to its high morbidity rate, early diagnosis and appropriate medical therapy is essential. Methods: The article highlights normal blood alterations like anaemia, thrombocytopenia, leukocytosis and advanced diagnostic aids like flow cytometry, special staining as a diagnostic modality as well as for prognostic information in acute leukaemia, particularly as a tool for assigning lineage and facilitating further pathologic classification which may be helpful in influencing treatment strategies.Results: On clinical examination the case presented with features of inflammatory gingival enlargement with presence of local deposits and calculus. Routine blood examination anaemia, thrombocytopenia, leukocytosis with haemoglobin 5.6 gm% and total leukocyte count of 1,12,000 / cu mm suggestive of leukaemia. Myeloperoxidase and leukocyte nonspecific esterase (NSE special stain were used which showed presence of myeloblasts in the peripheral smear suggestive of acute myelocytic leukaemia. Flow cytometry were done which further helped in interpretation of these cells which showed to be strongly positive for CD45, CD13, CD14, and anti HLADR and moderately positive for CD4, CD34 and Anti MPO confirming to be case of AML-M4 with 57.73% gating.Conclusions: Fact that gingival alterations are sometimes the first manifestations of the disease implies that dental professionals must be sufficiently familiarized with the clinical manifestations of systemic diseases. The timely referral by the general dentist for a suspicious lesion provided an early diagnosis and early intervention reducing the patient morbidity.

  10. Phospholipids trigger Cryptococcus neoformans capsular enlargement during interactions with amoebae and macrophages.

    Directory of Open Access Journals (Sweden)

    Cara J Chrisman

    2011-05-01

    Full Text Available A remarkable aspect of the interaction of Cryptococcus neoformans with mammalian hosts is a consistent increase in capsule volume. Given that many aspects of the interaction of C. neoformans with macrophages are also observed with amoebae, we hypothesized that the capsule enlargement phenomenon also had a protozoan parallel. Incubation of C. neoformans with Acanthamoeba castellanii resulted in C. neoformans capsular enlargement. The phenomenon required contact between fungal and protozoan cells but did not require amoeba viability. Analysis of amoebae extracts showed that the likely stimuli for capsule enlargement were protozoan polar lipids. Extracts from macrophages and mammalian serum also triggered cryptococcal capsular enlargement. C. neoformans capsule enlargement required expression of fungal phospholipase B, but not phospholipase C. Purified phospholipids, in particular, phosphatidylcholine, and derived molecules triggered capsular enlargement with the subsequent formation of giant cells. These results implicate phospholipids as a trigger for both C. neoformans capsule enlargement in vivo and exopolysaccharide production. The observation that the incubation of C. neoformans with phospholipids led to the formation of giant cells provides the means to generate these enigmatic cells in vitro. Protozoan- or mammalian-derived polar lipids could represent a danger signal for C. neoformans that triggers capsular enlargement as a non-specific defense mechanism against potential predatory cells. Hence, phospholipids are the first host-derived molecules identified to trigger capsular enlargement. The parallels apparent in the capsular response of C. neoformans to both amoebae and macrophages provide additional support for the notion that certain aspects of cryptococcal virulence emerged as a consequence of environmental interactions with other microorganisms such as protists.

  11. Enlargement of thalamic nuclei in Tourette syndrome

    DEFF Research Database (Denmark)

    Miller, Ann M; Bansal, Ravi; Hao, Xuejun;

    2010-01-01

    were 5% larger in the group composed of children and adults with TS. Statistical maps of surface contour demonstrated enlargement over the lateral thalamus. Post hoc testing indicated that differences in IQ, comorbid illnesses, and medication use did not account for these findings. CONCLUSIONS...

  12. Nato enlarging into the Baltic States

    Index Scriptorium Estoniae

    2003-01-01

    Prahas 21.-22. novembrini 2002 toimunud NATO tippkohtumisest ja seal vastu võetud otsusest Balti riikide alliansiga ühinemise kohta. Vt. samas: Russia's attitude to the NATO enlargement; Bush in Vilnius; Baltic states' prime ministers' met; Supporting USA?

  13. HPP SHPILJE 2 - Hydro power capacities - enlargement

    International Nuclear Information System (INIS)

    The total generation capacity of the Republic of Macedonia power system is 1444 MW out of which 1010 MW are installed in thermal power plants and 434 MW in hydro power plants. The hydropower production has specific and highly defined place in the electricity sector as a peaking capacity, so it is very important for Macedonia to extend the hydropower capacities. HPP Shpilje was put into operation in 1969. During plant's operation the available water was used rationally and the overflows were minimal. This was achieved by enlargement of the of the storage useful area by decreasing the minimal operation level, from optimal level of 575,00 m.a.S.L. to 562,00 m.a.S.L., thus enabling better regulation of the flows and preventing the overflows. However, this storage enlargement decreased the net head of the power plant and also the power capacity and the electricity generation. Optimal way to solve the previously mentioned problems is additional enlargement of the installed capacity of HPP Shpilje. This paper will discuss the possibilities for enlargement and optimal solution for that. (Author)

  14. A rapidly enlarging cutaneous hemangioma in pregnancy.

    LENUS (Irish Health Repository)

    Ma'ayeh, Marwan

    2014-06-18

    This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient\\'s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor.

  15. Penile Enlargement : From Medication to Surgery

    NARCIS (Netherlands)

    Nugteren, Helena M.; Balkema, G. T.; Pascal, A. L.; Schultz, W. C. M. Weijmar; Nijman, J. M.; Van Driel, M. F.

    2010-01-01

    Penis lengthening pills, stretch apparatus, vacuum pumps, silicone injections, and lengthening and thickening operations are available for men who worry about their penis size. Surgery is thus far the only proven scientific method for penile enlargement. In this article, we consider patient selectio

  16. Enlarged pancreas:not always a cancer

    Institute of Scientific and Technical Information of China (English)

    Lucia Calculli; Davide Festi; Raffaele Pezzilli

    2015-01-01

    Pancreatic fat accumulation has been described with various terms including pancreatic lipomatosis, pancre-atic steatosis, fatty replacement, fatty infiltration, fatty pan-creas, lipomatous pseudohypertrophy and nonalcoholic fatty pancreas disease. It has been reported to be associated with type 2 diabetes mellitus, acute pancreatitis, pancreatic cancer and the formation of pancreatic fistula. The real incidence of this condition is still unknown. We report a case of pancreatic steatosis in a non-obese female patient initially diagnosed with a mass in the head of the pancreas. Magnetic resonance imaging (MRI) was carried out to define the characteristics of the pancreatic mass. MRI confirmed the diagnosis of fat pan-creas. Enlarged pancreas is not always a cancer, but pancreatic steatosis is characterized by pancreatic enlargement. MRI could give a definite diagnosis of pancreatic steatosis or cancer.

  17. NATO enlargement and its implications for Turkey

    OpenAIRE

    Çatal, Erdoğan

    2001-01-01

    Cataloged from PDF version of article. NATO, which has been throughout the Cold War a collective defense organization, was considered either useless or out of date with the end of the Cold War. However, as it did in the early years of the Cold War, habitually originating from its own dynamics, NATO transformed itself in order to meet the imperatives of the post-Cold War international environment. The geographical enlargement of NATO is the centerpiece of this whole transform...

  18. On How to Enlarge Students’Vocabulary

    Institute of Scientific and Technical Information of China (English)

    ZHANG Chun-xiao

    2015-01-01

    It is of vital importance to enlarge students’vocabulary in English teaching. The methods are:letting students realize the importance of words;teaching English word formation knowledge in class,for example, affixation, conversion, composition, blend⁃ing,backformation,shortening;teaching synonyms and antonyms,teaching words similar in spelling;words association, letting stu⁃dents reading widely;memorizing word lists and so on.

  19. Price convergence in the enlarged internal market

    OpenAIRE

    Dreger, Christian; Kholodilin, Konstantin; Lommatzsch, Kirsten; Slacalek, Jirka; Wozniak, Przemyslaw

    2007-01-01

    In this paper we investigate the effects of EU enlargement on price convergence. The internal market is expected to boost integration and increase efficiency and welfare through a convergence of prices in product markets. Two principal drivers are crucial to explain price developments. On the one hand, higher competition exerts a downward pressure on prices because of lower mark ups. On the other hand, the catching up process of low income countries leads to a rise in the price levels and hig...

  20. Enlarging mediastinal/hilar lymphadenopathy with calcification.

    Science.gov (United States)

    Adachi, Takashi; Nakahata, Masashi; Moritani, Suzuko; Iida, Hiroatsu; Ogawa, Kenji

    2016-02-01

    A 77-year-old man was referred to our hospital due to enlarging mediastinal/hilar lymphadenopathy with calcification. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and bone marrow aspiration were performed. Subsequently, monoclonal gammopathy of undetermined significance (MGUS) associated with mediastinal amyloidosis was diagnosed. We hereby report a case in which EBUS-TBNA led to a successful diagnosis of amyloidosis. PMID:26862422

  1. Fiscal Convergence in an Enlarged European Union

    OpenAIRE

    Georgeta VINTILĂ; Mihaela ONOFREI; Ioana Laura ŢIBULCĂ

    2014-01-01

    Taxation convergence in the European Union has always been a heatedly debated issue, and it has constantly resurfaced to the limelight as more and more fiscal directive proposals are being discussed. The current study is an analysis of the evolution of taxation convergence tendencies within the European Union in recent years, using sigma-convergence and cluster analysis. Our goal is to analyze the fiscal convergence trends in the context of European Union enlargement over the last two decades.

  2. Fiscal Convergence in an Enlarged European Union

    Directory of Open Access Journals (Sweden)

    Georgeta VINTILĂ

    2014-02-01

    Full Text Available Taxation convergence in the European Union has always been a heatedly debated issue, and it has constantly resurfaced to the limelight as more and more fiscal directive proposals are being discussed. The current study is an analysis of the evolution of taxation convergence tendencies within the European Union in recent years, using sigma-convergence and cluster analysis. Our goal is to analyze the fiscal convergence trends in the context of European Union enlargement over the last two decades.

  3. Penile enlargement: from medication to surgery.

    Science.gov (United States)

    Nugteren, Helena M; Balkema, G T; Pascal, A L; Schultz, W C M Weijmar; Nijman, J M; van Driel, M F

    2010-01-01

    Penis lengthening pills, stretch apparatus, vacuum pumps, silicone injections, and lengthening and thickening operations are available for men who worry about their penis size. Surgery is thus far the only proven scientific method for penile enlargement. In this article, we consider patient selection, outcome evaluation, and techniques applied. In our view, sexological counseling and detailed explanation of risks and complications are mandatory before any operative intervention. PMID:20169492

  4. The Good Neighbourliness Condition in EU Enlargement

    Directory of Open Access Journals (Sweden)

    Elena Basheska

    2014-05-01

    Full Text Available Good neighbourliness is one of the most important principles relating to harmonious interstate relations. It primarily developed in international law around the idea of territorial sovereignty of states. The principle was further translated into an important accession condition in EU enlargement policy. A violation of the good neighbourliness principle can lead to serious confrontations or military conflicts between states. Yet, the respect of the principle requires precise definition of its legal substance. As a paradox, the good neighbourliness principle has not been codified in international law. The lack of sufficient clarification of the essence of the principle potentially undermines the success of the Union’s engagement with it, threatening to lead to inconsistent interpretation and even to wrongful implementation of the good neighbourliness principle. The paper clarifies the legal basis of the principle in international law and traces the application of the corollary condition in EU enlargement policy where conditionality is deployed. It focuses on the application of the condition to settlements of bilateral disputes in the enlargement process. The paper concludes that the EU’s efforts to implement the good neighbourliness condition in accordance with international law have failed so far.

  5. Ventricular enlargement in patients with affective disorders

    International Nuclear Information System (INIS)

    Ventricular enlargement was determined using linear measurement on MR images in a total of 71 patients with affective disorders, including bipolar affective disorder (41) and depression (30). Fourty-one healthy persons served as controls. Evans ratio, Huckman number and minimum distance of caudate nuclei (MDCN) were used as indices for ventricular enlargment. No significant difference in Evans ratio was observed between both the group of bipolar affective disorder and the group of depression and the control group. Nor did it correlate with age in any of the groups. Huckman number was significantly higher in the group of bipolar affective disorder than the other two groups. It positively correlated with age in the group of depression. MDCN was significantly increased in the group of bipolar affective disorder, as compared with the control group; and there was a positive correlation between MDCN and age in both the group of dipolar affective disorder and the group of depression. In conclusion, ventricular enlargement was dependent upon aging in affetive disorder patients. This tendency was more noticeable in the group of depression. In addition, atrophy of the caudate nuclei was likely to be severer in the group of dipolar affective disorder than the group of depression. (N.K.)

  6. Diagnostic dilemmas in enlarged and diffusely hemorrhagic adrenal glands.

    Science.gov (United States)

    Diolombi, Mairo L; Khani, Francesca; Epstein, Jonathan I

    2016-07-01

    We have noted an increasing number of cases of enlarged adrenal glands where the underlying diagnosis was masked by a diffusely hemorrhagic process. We identified from our database 59 cases (32 consults, 27 routine) of adrenal glands with diffuse (>25%) hemorrhage received between 2000 and 2014. Fifty-three adrenalectomies and 6 biopsies were identified. The diagnoses after central review were 41 adrenocortical adenomas, 1 nodular adrenocortical hyperplasia with associated myelolipoma, 1 benign adrenocortical cyst, and 10 nonneoplastic adrenal glands with hemorrhage. A definitive diagnosis for the 6 biopsies was precluded by the sample size. The adrenocortical adenomas (size, 1-13 cm; 25%-95% hemorrhage) showed clear cell change in the neoplastic area (10%-80% of the tumor), 19 showed focal calcification (1 with ossification), 11 showed areas of papillary endothelial hyperplasia, 10 showed scattered lymphoplasmacytic inflammation, 6 showed benign cortical tissue extending beyond the adrenal capsule into soft tissue, 1 showed necrosis in the form of ghost cells, 2 showed lipomatous change, and 6 were associated with incidental benign lesions (1 cortical cyst, 1 schwannoma, and 4 myelolipomas). Twenty-four of the adrenocortical adenomas were consults where the referring pathologist had trouble classifying the lesion. Of the 10 nonneoplastic adrenals (4.5-22 cm; 40%-80% hemorrhage), 2 were consults. In summary, pathologists have difficulties recognizing adrenocortical adenomas in the setting of a massively enlarged and hemorrhagic adrenal gland. Although there is a correlation between adrenocortical malignancy and size, hemorrhage into nonmalignant adrenal glands can result in markedly enlarged adrenals. PMID:27001431

  7. Martingale representation property in progressively enlarged filtrations

    CERN Document Server

    Jeanblanc, M

    2012-01-01

    Consider $\\mathbb{G}$ the progressive enlargement of a filtration $\\mathbb{F}$ with a random time $\\tau$. Assuming that, in $\\mathbb{F}$, the martingale representation property holds, we examine conditions under which the martingale representation property holds also in $\\mathbb{G}$. It is noted that the classical results on this subject are no more sufficient to deal with all examples coming from credit risk modeling. In this paper, we introduce a new methodology which extends the various classical results and applies on recent examples.

  8. The European Union: Eastern Enlargement and Taxation

    OpenAIRE

    van der Hoek, M. Peter

    2004-01-01

    The European Union has not defined its limits in geographical terms. Each enlargement has led and will lead to a decrease of the European Union’s per capita GDP. After the collapse of the Soviet Union the transition countries went through a long and deep recession. However, they have reached a stage of positive growth and their tax levels are approaching the lower limit of the range of tax/GDP ratios in European Union countries. Differences exist in tax capacity and tax effort. In some countr...

  9. Emergency radiology. 2. rev. and enlarged ed.

    International Nuclear Information System (INIS)

    This second edition of the book is a substantially enlarged version of the first one. Much more space has been given to non-conventional methods such as scintiscanning, computerized tomography, ultrasonography, and NMR imaging, in addition to the chapters on routine diagnostic radiography. The material is arranged as before, by anatomy aspects, presenting seven chapters referring to the cranium, visceral cranium, vertebral spine, thorax, abdomen, pelvis and hip, and the extremities. The eighth chapter deals with the particular problems encountered in pediatric emergency radiology. (MG) With 770 figs

  10. Midwifery and the enlarged European Union.

    Science.gov (United States)

    Mead, Marianne

    2003-06-01

    The freedom of movement of midwives within the European Union has been guaranteed by the application of midwives' sectoral directives signed in 1980 and applied in 1983. Since then the size of the European Union has grown from 9 to 15 members and is due for a next wave of enlargement of another 10 member states in 2004. The rules and regulations that govern the European Union are being revisited to accommodate this change. Midwifery will be affected and some changes are potentially worrying, in particular the proposed loss of the Advisory Committee on the Training of Midwives. Six other professions regulated in a very similar way are also to lose their own advisory committees. The European Commission has proposed the adoption of a single directive for all professions, together with the setting up of an expert group whose function would be to deal principally with health professions. However, neither its remit nor its membership has been determined. Whereas previous movement of midwives within Europe has been minimal, it is anticipated that this may well be changed at the next enlargement stage. Without clear directives and some form of controlling power at European level, public health may be threatened. In this paper the developments to date and the concerns that have emerged from the recent proposals are outlined. PMID:12809627

  11. Patient with bilateral breast enlargement and hypospadias.

    Science.gov (United States)

    Ali, A A; Ahmed, T; Rashid, M M

    2009-01-01

    A 20 year old man was admitted in the surgical unit of Dhaka Medical College Hospital on August 2007 presented with Hypospadias & underdeveloped penis from childhood, gradual enlargement of both breasts for the last 10 years, absence of axillary and pubic hair from puberty & painful swelling of both testes for the last 3 years. The patient was regarded as a female upto the age of 10 years. He has got no voice change since puberty. On examination he had average body built, there was bilateral gynaecomastia, hypospadias, rudimentary penis & absence of pubic and axillary hair. His testosterone level, serum prolactin level, serum progesterone level, serum estradiol level was done. Cytology on buccal smear done and ultrasonography revealed no ovary and uterus. Ultimately patient was diagnosed as a case of androgen insensitivity syndrome (AIS). The case is reported for clinical awareness & to share our experience. PMID:19182761

  12. Conductance enlargement in picoscale electroburnt graphene nanojunctions

    Science.gov (United States)

    Sadeghi, Hatef; Mol, Jan A.; Lau, Chit Siong; Briggs, G. Andrew D.; Warner, Jamie; Lambert, Colin J.

    2015-01-01

    Provided the electrical properties of electroburnt graphene junctions can be understood and controlled, they have the potential to underpin the development of a wide range of future sub-10-nm electrical devices. We examine both theoretically and experimentally the electrical conductance of electroburnt graphene junctions at the last stages of nanogap formation. We account for the appearance of a counterintuitive increase in electrical conductance just before the gap forms. This is a manifestation of room-temperature quantum interference and arises from a combination of the semimetallic band structure of graphene and a cross-over from electrodes with multiple-path connectivity to single-path connectivity just before breaking. Therefore, our results suggest that conductance enlargement before junction rupture is a signal of the formation of electroburnt junctions, with a picoscale current path formed from a single sp2 bond. PMID:25730863

  13. Subsidy policy and the enlargement of choice

    International Nuclear Information System (INIS)

    Development is the enlargement of people's choices. Optimal subsidy policy is intended to create the right incentives for each of the value chain participants. This paper contends that the interest subsidy offered by the Indian federal Ministry of New and Renewable Energy for solar thermal systems, through mainstream banking channels is superior in intent and outcome compared to the capital subsidy as currently offered for solar PV systems, routed through government controlled delivery channels. The interest subsidy enhances innovation, improves service delivery and expands the range of product available to consumers enjoying a wide range of endowments, thus leading to more inclusive development. The simple monopoly model developed by Atkinson [Atkinson AB. Capabilities, exclusion and the supply of goods. In: Basu K, Pattanaik P, Suzumura K, editor, Choice, Welfare and Development. Oxford University Press; 1995] is applied to the context of solar home systems to demonstrate price reduction and choice expansion in a liberalized market, facilitated by an interest subsidy scheme. (author)

  14. EU Enlargement Law: History and Recent Developments: Treaty Custom Concubinage?

    Directory of Open Access Journals (Sweden)

    Dimitry Kochenov

    2005-04-01

    Full Text Available This note provides a detailed account of the development of the EU enlargement law. Based on the material provided by the latest enlargement round, it outlines the main set of enlargement principles, criteria and procedural tools employed by the Union in the process, also making a sketch of the actual chronology of enlargement events. Based on the analysis of the legal regulation of five rounds of enlargement and making parallels with the notion of customary law as understood in public international law, it argues that the Union enlargements have always enjoyed a dual regulation: by written (mostly Treaty based and also by customary enlargement law. The existence of customary law explains the consistency of enlargement regulation throughout all the rounds of this process, notwithstanding the stage of the Treaty reform in force at the time of every particular accession. The minimal amendments introduced into the enlargement article by the Treaty Establishing a Constitution for Europe (Art. I-58 suggest that the future enlargements are likely to be building on the body of customary law in force to date. The process of gradual incorporation of customary law into the written law of the EU is also likely to continue.

  15. Essential role of the unordered VP2 n-terminal domain of the parvovirus MVM capsid in nuclear assembly and endosomal enlargement of the virion fivefold channel for cell entry

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez-Martinez, Cristina; Grueso, Esther [Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Universidad Autonoma de Madrid, 28049 Cantoblanco, Madrid (Spain); Carroll, Miles [Health Protection Agency, Centre for Emergency Preparedness and Response, Porton Down, Salisbury SP4 OJG, Wilts (United Kingdom); Rommelaere, Jean [Deutsches Krebsforschungszentrum Division F010, Im Neuenheimer Feld 242, D-69120 Heidelberg (Germany); Almendral, Jose M., E-mail: jmalmendral@cbm.uam.es [Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Universidad Autonoma de Madrid, 28049 Cantoblanco, Madrid (Spain)

    2012-10-10

    The unordered N-termini of parvovirus capsid proteins (Nt) are translocated through a channel at the icosahedral five-fold axis to serve for virus traffick. Heterologous peptides were genetically inserted at the Nt of MVM to study their functional tolerance to manipulations. Insertion of a 5T4-single-chain antibody at VP2-Nt (2Nt) yielded chimeric capsid subunits failing to enter the nucleus. The VEGFR2-binding peptide (V1) inserted at both 2Nt and VP1-Nt efficiently assembled in virions, but V1 disrupted VP1 and VP2 entry functions. The VP2 defect correlated with restricted externalization of V1-2Nt out of the coat. The specific infectivity of MVM and wtVP-pseudotyped mosaic MVM-V1 virions, upon heating and/or partial 2Nt cleavage, demonstrated that some 2Nt domains become intracellularly translocated out of the virus shell and cleaved to initiate entry. The V1 insertion defines a VP2-driven endosomal enlargement of the channel as an essential structural rearrangement performed by the MVM virion to infect.

  16. German and British Trade Unions: Problems and opportunities after enlargement

    OpenAIRE

    ZAHN, Rebecca

    2011-01-01

    This paper examines and compares German and British trade union responses in a European context following the recent European enlargements in 2004 and 2007, enlargements that are unprecedented in the history of the European Union. In particular, the paper undertakes a contextualized comparison of trade union behaviour in responding to the changing regulatory and opportunity structures which present themselves following the enlargements. Account is taken of the role that trade unions adopt wit...

  17. [Enlargement in managment of lumbar spinal stenosis].

    Science.gov (United States)

    Steib, J P; Averous, C; Brinckert, D; Lang, G

    1996-05-01

    Lumbar stenosis has been well discussed recently, especially at the 64th French Orthopaedic Society (SOFCOT: July 1989). The results of different surgical treatments were considered as good, but the indications for surgical treatment were not clear cut. Laminectomy is not the only treatment of spinal stenosis. Laminectomy is an approach with its own rate of complications (dural tear, fibrosis, instability... ).Eight years ago, J. Sénégas described what he called the "recalibrage" (enlargement). His feeling was that, in the spinal canal, we can find two different AP diameters. The first one is a fixed constitutional AP diameter (FCAPD) at the cephalic part of the lamina. The second one is a mobile constitutional AP diameter (MCAPD) marked by the disc and the ligamentum flavum. This diameter is maximal in flexion, minimal in extension. The nerve root proceeds through the lateral part of the canal: first above, between the disc and the superior articular process, then below, in the lateral recess bordered by the pedicle, the vertebral body and the posterior articulation. With the degenerative change the disc space becomes shorter, the superior articular process is worn out with osteophytes. These degenerative events are complicated by inter vertebral instability increasing the stenosis. The idea of the "recalibrage" is to remove only the upper part of the lamina with the ligamentum flavum and to cut the hypertrophied anterior part of the articular process from inside. If needed the disc and other osteophytes are removed. The surgery is finished with a ligamentoplasty reducing the flexion and preventing the extension by a posterior wedge.Our experience in spine surgery especially in scoliosis surgery, showed us that it was possible to cure a radicular compression without opening the canal. The compression is then lifted by the 3D reduction and restoration of an anatomy as normal as possible. Lumbar stenosis is the consequence of a degenerative process. Indeed, hip

  18. Western Balkans: sixth enlargement of the European Union

    OpenAIRE

    Monzonis-Vilallonga, Jorge Fuentes

    2005-01-01

    After the enlargement to Central and Eastern Europe, the process of European integration has advanced, but it is still not complete. Twenty countries are still not members of the EU. The republics of Western Balkans are likely candidates for the next wave of enlargement.

  19. Growth and the Enlargement of a Common Market

    Directory of Open Access Journals (Sweden)

    Cheng-Te Lee

    2013-12-01

    Full Text Available This paper explores the growth effects of the enlargement of a common market from two to three countries by making use of a three-country equilibrium growth model with heterogeneous labour. We prove that the enlargement will stimulate the backward countries’ economic growth. In addition, we also demonstrate that the higher the new member country’s average talent level is, the more likely it is that the enlargement can speed up the initial integrated-economy’s economic growth.

  20. Doorkeepers and Gatecrashers: EU Enlargement and Negotiation Strategies

    DEFF Research Database (Denmark)

    Brücker, Herbert; Schröder, Philipp; Weise, Christian

    2004-01-01

    This paper discusses the eastward enlargement process of the EU in the framework of a simple war of attrition bargaining game. Both players -- the existing EU members and the applicants -- benefit from enlargement, yet for the applicants, reform to the acquis is costly, while the EU prefers...... substantially reformed candidates. A waiting game unfolds. Within this framework the present enlargement round is analysed and policy results are deduced. For example, it is shown that delegating the evaluation of applicants to a third party, compensating applicants for their reform efforts or increasing the...... benefits for new members are all effective negotiation strategies for the EU that have been applied in the process....

  1. Challenges for monetary policy in the enlarged European monetary Union

    Directory of Open Access Journals (Sweden)

    Radović Irena

    2009-01-01

    Full Text Available The eastward enlargement of the Euro area entails significant implications for the accession candidates in Central and Eastern Europe (CEE, the existing Euro system and the monetary policy of the European Central Bank (ECB. The present analysis assesses the challenges and critical aspects in monetary policy modeling with special emphasis to enlargement. The focus is on the difficulty of implementing a unique currency policy in view or growing heterogeneity within the enlarged monetary union, and secondly - the issue of the voting mechanism within the ECB. When analyzing those two issues, it is conclusive that the difficulties for the ECB and the current Euro zone members will increase. For the enlarged Euro zone, which is becoming more divergent, it will be very hard to find adequate recipes to meet the needs and requirements of all. The big question is: whether centralization of monetary policy is a sustainable and superior solution?.

  2. Extensions, expansions, Lie algebra cohomology and enlarged superspaces

    Energy Technology Data Exchange (ETDEWEB)

    Azcarraga, J A de [Departamento de FIsica Teorica, Facultad de FIsica and IFIC - Centro Mixto Universidad de Valencia-CSIC, E-46100 Burjassot, Valencia (Spain); Izquierdo, J M [Departamento de FIsica Teorica, Universidad de Valladolid, E-47011 Valladolid (Spain); Picon, M [Departamento de FIsica Teorica, Facultad de FIsica and IFIC - Centro Mixto Universidad de Valencia-CSIC, E-46100 Burjassot, Valencia (Spain); Varela, O [Departamento de FIsica Teorica, Facultad de FIsica and IFIC - Centro Mixto Universidad de Valencia-CSIC, E-46100 Burjassot, Valencia (Spain)

    2004-05-21

    After briefly reviewing the methods that allow us to derive consistently new Lie (super)algebras from given ones, we consider enlarged superspaces and superalgebras, their relevance and some possible applications.

  3. POSSIBLE TRADE EFFECTS OF THE NEXT EUROPEAN UNION ENLARGEMENT

    OpenAIRE

    Nedelescu-Ionescu Daniela; Rujan Ovidiu

    2012-01-01

    The European Union next enlargement will constitute a significant qualitative change in the structure of the current Union, as the accession of the Western Balkan countries and of Turkey in particular will bring a brand new set of economic problems. It is expected that this enlargement to have a considerable effect for the new entrants, as well as for the European Union as a whole.\\\\r\\\

  4. POSSIBLE TRADE EFFECTS OF THE NEXT EUROPEAN UNION ENLARGEMENT

    Directory of Open Access Journals (Sweden)

    Nedelescu-Ionescu Daniela

    2012-07-01

    Full Text Available The European Union next enlargement will constitute a significant qualitative change in the structure of the current Union, as the accession of the Western Balkan countries and of Turkey in particular will bring a brand new set of economic problems. It is expected that this enlargement to have a considerable effect for the new entrants, as well as for the European Union as a whole.\\r\

  5. European Union: Promises and Challenges of a New Enlargement

    OpenAIRE

    Pusca, Anca

    2004-01-01

    A sourcebook on contemporary controversies, this book brings together articles discussing controversial questions raised by European Enlargement towards Eastern Europe, Cyprus and Turkey. The first section of the book presents points of view from each of the applicant countries with regard to specific problems of European Enlargement, grouped under sections dealing with issues of democratic representation and citizenship rights, social, political and economic impacts of the acquis communautai...

  6. Prevalence of gingival enlargement in Karnataka school going children

    OpenAIRE

    Krishna, K Bala; Raju, P Krishnam; Chitturi, Radha Raani; Smitha, G; Vijai, S; Srinivas, B. V. V.

    2014-01-01

    Background: Periodontal diseases affect more people all over the world than dental caries. Increase in size of gingiva is known as gingival hyperplasia or gingival enlargement. Gingival swelling is almost universally the result of Fluid accumulation within the tissues. Enlargement and even aesthetically disfiguring over growth of the gingival tissue, is also a common finding of leukemia, scurvy and subjects undergoing the hormonal changes of puberty, pregnancy, menopause and drugs.

  7. Enlarged perivascular spaces and cerebral small vessel disease

    OpenAIRE

    Potter, Gillian M; Doubal, Fergus N; Jackson, Caroline A; Chappell, Francesca M; Sudlow, Cathie L; Dennis, Martin S; Wardlaw, Joanna M.

    2013-01-01

    Background and aims Enlarged perivascular spaces (also known as Virchow–Robin spaces) on T2-weighted brain magnetic resonance imaging are common, but their etiology, and specificity to small vessel as opposed to general cerebrovascular disease or ageing, is unclear. We tested the association between enlarged perivascular spaces and ischemic stroke subtype, other markers of small vessel disease, and common vascular risk factors. Methods We prospectively recruited patients with acute stroke, di...

  8. The performance of a centrifugal fan with enlarged impeller

    International Nuclear Information System (INIS)

    Highlights: → The influence of impeller enlargement is evaluated numerically and experimentally. → Variation equations of the operation points for enlarged impellers are derived. → Impeller enlargement leads to louder fan noise due to reduced impeller-volute gap. - Abstract: The influence of enlarged impeller in unchanged volute on G4-73 type centrifugal fan performance is investigated in this paper. Comparisons are conducted between the fan with original impeller and two larger impellers with the increments in impeller outlet diameter of 5% and 10% respectively in the numerical and experimental investigations. The internal characteristics are obtained by the numerical simulation, which indicate there is more volute loss in the fan with larger impeller. Experiment results show that the flow rate, total pressure rise, shaft power and sound pressure level have increased, while the efficiency have decreased when the fan operates with larger impeller. Variation equations on the performance of the operation points for the fan with enlarged impellers are suggested. Comparisons between experiment results and the trimming laws show that the trimming laws for usual situation can predict the performance of the enlarged fan impeller with less error for higher flow rate, although the situation of application is not in agreement. The noise frequency analysis shows that higher noise level with the larger impeller fan is caused by the reduced impeller-volute gap.

  9. Rib enlargement in premature infants with bronchopulmonary dysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Hye Kyung; Han, Kim Bokyung; Chang, Yun Sil; Choo, In Wook [Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul (Korea, Republic of); Kim, Kyeong Ah [Anyang General Hospital, Anyang (Korea, Republic of)

    2000-04-01

    The purpose of this study is to describe the rib changes seen in patients with brochopulmonary dysplasia (BPD). Serial chest radiographs of nine premature infants with BPD who showed diffuse rib enlargement were reviewed for hyperinflation, which was compared with the observed degree of rib enlargement. Vibrator chest physiotherapy was performed in all cases, and five infants underwent conventional ventilation plus high frequency oscillatory ventilation therapy. Their calcium level was normal whereas alkaline phosphatase and phosphate levels were high. In all infants except one, liver enzyme levels were normal. For the treatment of patent ductus arteriosus, infection, and BPD, medications including indomethacin, antibiotics, and dexamethasone were administered. Vitamin D was given to all patients with total parenteral nutrition. Rib enlargement was found to be severe (n=3D4), moderate (n=3D3), or mild (n=3D2) with undulating margins or posterior tapering (n=3D2). Hyperinflation was noted in eight patients, in seven of whom it was moderate to severe. Among these seven, rib enlargement was severe (n=3D2), moderate (n=3D3), or mild (n=3D2). In one infant with mild hyperinflation, rib enlargement was severe. Bilateral irregular infiltrates and atelectases were noted in all patients. In BPD patients, rib enlargement may be seen. In order to differentiate this process from systemic bone disease or bony dysplasia, an awareness of the rib changes occurring in patients with BPD may be important. (author)

  10. Rib enlargement in premature infants with bronchopulmonary dysplasia

    International Nuclear Information System (INIS)

    The purpose of this study is to describe the rib changes seen in patients with brochopulmonary dysplasia (BPD). Serial chest radiographs of nine premature infants with BPD who showed diffuse rib enlargement were reviewed for hyperinflation, which was compared with the observed degree of rib enlargement. Vibrator chest physiotherapy was performed in all cases, and five infants underwent conventional ventilation plus high frequency oscillatory ventilation therapy. Their calcium level was normal whereas alkaline phosphatase and phosphate levels were high. In all infants except one, liver enzyme levels were normal. For the treatment of patent ductus arteriosus, infection, and BPD, medications including indomethacin, antibiotics, and dexamethasone were administered. Vitamin D was given to all patients with total parenteral nutrition. Rib enlargement was found to be severe (n=3D4), moderate (n=3D3), or mild (n=3D2) with undulating margins or posterior tapering (n=3D2). Hyperinflation was noted in eight patients, in seven of whom it was moderate to severe. Among these seven, rib enlargement was severe (n=3D2), moderate (n=3D3), or mild (n=3D2). In one infant with mild hyperinflation, rib enlargement was severe. Bilateral irregular infiltrates and atelectases were noted in all patients. In BPD patients, rib enlargement may be seen. In order to differentiate this process from systemic bone disease or bony dysplasia, an awareness of the rib changes occurring in patients with BPD may be important. (author)

  11. An unusual case of Burkitt's lymphoma presenting as a gingival enlargement

    OpenAIRE

    Neerja Sethi; Sangeeta Patankar; Rohit Jain; Ankit Mehta

    2015-01-01

    Burkitt's lymphoma is an undifferentiated non-Hodgkin's B-cell lymphoma. Three clinical subtypes are recognized: African (endemic), American and other areas (sporadic) and human immunodeficiency virus (HIV) associated. Sporadic Burkitt's lymphoma is a rare malignancy among Asian population. This report describes a case of sporadic Burkitt's lymphoma presenting as generalized gingival enlargement with an alarmingly rapid spread. This type of rapid progression bespeaks the need for prompt recog...

  12. Surgical management of generalized gingival enlargement - a case series

    International Nuclear Information System (INIS)

    Generalized gingival enlargement is characterized by massive and exuberant gingival overgrowth that poses social, aesthetic, phonetic and functional problems for the patient. Therefore, it requires meticulous management. Objective: To describe the surgical management of generalized gingival enlargement by electrosurgical excision of patients presenting to a tertiary care centre. Study Design: Case series. Materials and Methods: The study was conducted at the Department of Oral and Maxillofacial Surgery, de'Montmorency College of Dentistry, Lahore, from January 2010 to December 2012. A total of sixteen patients were operated by using electrosurgical approach under general anaesthesia for surgical excision of generalized gingival enlargement. Results: All of the sixteen patients, 11 males and 5 females, showed excellent healing postoperatively without any recurrent gingival overgrowth. Discussion: To the best of our knowledge, the current study presents the largest case series of generalized gingival enlargement. Most of these cases were with massive disease due to lack of information of the study population about their disease, delay in referral by the general dental practitioners, painless and innocent nature of the problem. Early referral of such patients to tertiary care centers can prevent the patients from social and psychological embarrassment. Conclusion: Electrosurgical excision is an excellent surgical technique for management of generalized gingival enlargement. Moreover, cross comparative studies are required to establish some diagnostic and therapeutic standards for such patients. (author)

  13. Disodium cromoglycate attenuates hypoxia induced enlargement of end-expiratory lung volume in rats.

    Science.gov (United States)

    Maxová, H; Hezinová, A; Vízek, M

    2011-01-01

    Mechanism responsible for the enlargement of end-expiratory lung volume (EELV) induced by chronic hypoxia remains unclear. The fact that the increase in EELV persists after return to normoxia suggests involvement of morphological changes. Because hypoxia has been also shown to activate lung mast cells, we speculated that they could play in the mechanism increasing EELV similar role as in vessel remodeling in hypoxic pulmonary hypertension (HPH). We, therefore, tested an effect of mast cells degranulation blocker disodium cromoglycate (DSCG) on hypoxia induced EELV enlargement. Ventilatory parameters, EELV and right to left heart weight ratio (RV/LV+S) were measured in male Wistar rats. The experimental group (H+DSCG) was exposed to 3 weeks of normobaric hypoxia and treated with DSCG during the first four days of hypoxia, control group was exposed to hypoxia only (H), two others were kept in normoxia as non-treated (N) and treated (N+DSCG) groups. DSCG treatment significantly attenuated the EELV enlargement (H+DSCG = 6.1+/-0.8; H = 9.2+/-0.9; ml +/-SE) together with the increase in minute ventilation (H + DSCG = 190+/-8; H = 273 +/- 10; ml/min +/- SE) and RV/LV + S (H + DSCG = 0.39 +/- 0.03; H = 0.50 +/- 0.06). PMID:22106819

  14. Peculiar enlargement of the nasopharynx in patients with anorexia nervosa

    International Nuclear Information System (INIS)

    We examined the nasopharynx and brain in 17 patients with anorexia nervosa by CT and compared the findings with those of 44 normal subjects and of 5 patients of the same age with marked emaciation caused by various psychiatric disorders. An enlarged nasopharyngeal space with a flattened posterior wall and enlarged lateral pharyngeal recesses were demonstrated in all patients with anorexia nervosa whose weight was lowest at the time of the CT examination, and these CT features regressed or became normal quickly after they had gained some weight. This characteristic enlargement of the nasopharynx and lateral pharyngeal recesses was observed neither in the markedly emaciated patients (2 with schizophrenia, 1 with major depression, 1 with stupor and the other with an extremely unbalanced diet) nor in 44 normal subjects without emaciation. These features were therefore thought to be characteristic and of diagnostic significance. (orig.). With 5 figs., 3 tabs

  15. Peculiar enlargement of the nasopharynx in patients with anorexia nervosa

    Energy Technology Data Exchange (ETDEWEB)

    Okamoto, K. [Department of Radiology, School of Dentistry, Niigata Univ. (Japan); Ito, J. [Department of Radiology, School of Dentistry, Niigata Univ. (Japan); Tokiguchi, S. [Department of Radiology, School of Dentistry, Niigata Univ. (Japan); Kuwabara, G. [Department of Radiology, School of Medicine, Niigata University, Niigata (Japan); Nishihara, M. [Department of Radiology, School of Medicine, Niigata University, Niigata (Japan)

    1995-11-01

    We examined the nasopharynx and brain in 17 patients with anorexia nervosa by CT and compared the findings with those of 44 normal subjects and of 5 patients of the same age with marked emaciation caused by various psychiatric disorders. An enlarged nasopharyngeal space with a flattened posterior wall and enlarged lateral pharyngeal recesses were demonstrated in all patients with anorexia nervosa whose weight was lowest at the time of the CT examination, and these CT features regressed or became normal quickly after they had gained some weight. This characteristic enlargement of the nasopharynx and lateral pharyngeal recesses was observed neither in the markedly emaciated patients (2 with schizophrenia, 1 with major depression, 1 with stupor and the other with an extremely unbalanced diet) nor in 44 normal subjects without emaciation. These features were therefore thought to be characteristic and of diagnostic significance. (orig.). With 5 figs., 3 tabs.

  16. Gingival enlargement unveiling sarcoidosis: Report of a rare case

    Directory of Open Access Journals (Sweden)

    Sabeeha Abbas Kadiwala

    2013-01-01

    Full Text Available Sarcoidosis is classified as an acquired systemic granulomatous disease. Because of the fact that sarcoidosis affects multiple tissues and organs, it is characterized by many potential signs and symptoms, as well as by the presence of non-caseating granulomas in the organs involved. Although oral sarcoidosis is relatively rare, it may however, present in the oral cavity. This report presents a rare case of sarcoidosis with the initial presenting symptom as severe generalized gingival enlargement. The gingival enlargement was treated by gingivectomy. After histopathological examination of gingival biopsy and certain special investigations, a diagnosis of sarcoidosis was made.

  17. Enlarged uterus: Differentiation between adenomyosis and leiomyoma with MR imaging

    International Nuclear Information System (INIS)

    The potential of 1.5-T MR imaging in differentiating adenomyosis from leiomyoma was evaluated in 93 patients with clinically identifiable uterine enlargement. MR imaging findings were correlated with surgical/pathologic results in all cases. Pathologic findings showed that 71 cases of uterine enlargement were due to leiomyoma, 16 were due to adenomyosis, and six were due to involvement of both lesions. T2-weighted MR images correctly diagnosed 92 of 93 cases, and the differentiation was not possible in only the one case of adenomyosis. MR is a highly accurate imaging modality in the differentiation between adenomyosis and leiomyoma and will guide the appropriate treatment procedure

  18. Nifedipine-induced gingival enlargement: Correlation with dose and oral hygiene

    OpenAIRE

    Paramel Mohan Sunil; Jai Sanghar Nalluswami; Suman Jai Sanghar; Issac Joseph

    2012-01-01

    Gingival enlargement is a common finding in a routine dental practice. Though it has many etiological factors, enlargement due to drugs which are administered to treat the systemic problems is of major concern which needs attention. Here, we present a case of nifedipine-induced gingival enlargement and discuss the reason for the enlargement.

  19. Congress announcement: PHARM Connect Congress for Enlarged Europe 2012

    OpenAIRE

    Silvia Maina

    2012-01-01

    PHARM Connect Congress for Enlarged Europe 2012 is a must-attend event for Pharmaceutical industry professionals. Over two days (8-9 February, in Budapest), the conference will include the most up-to-date market insights into R&D, Production, Packaging, Supply Chain and Quality Management-related topics.

  20. Nuclear Safety Recommendations in the Context of EU enlargement

    International Nuclear Information System (INIS)

    The Atomic Questions Group and the Working Party on Nuclear Safety have prepared Report on Nuclear Safety in EU Candidate Countries in the Context of EU enlargement. Recommendations are of two kinds, i.e. general, applied to all candidate countries and county-specific. The list and short description of recommendations is presented

  1. Amygdala and Hippocampus Enlargement during Adolescence in Autism

    Science.gov (United States)

    Groen, Wouter; Teluij, Michelle; Buitelaar, Jan; Tendolkar, Indira

    2010-01-01

    Objective: The amygdala and hippocampus are key components of the neural system mediating emotion perception and regulation and are thought to be involved in the pathophysiology of autism. Although some studies in children with autism suggest that there is an enlargement of amygdala and hippocampal volume, findings in adolescence are sparse.…

  2. Consolidate Data Report for EU Enlargement and Neighbouring Countries

    OpenAIRE

    PANEV STRAHIL; BERTOLDI PAOLO

    2013-01-01

    This report consolidates data on residential buildings for the EU Enlargement countries: Albania; Bosnia and Herzegovina; Kosovo (under UN Security Council Resolution 1244/99); Montenegro, the Former Republic of Macedonia; Serbia and Turkey as well as for the European Neighbouring Countries: Ukraine and Moldova.

  3. EUROPEAN UNION ENLARGEMENT: WHAT ARE THE AGRICULTURAL TRADE MODELS MISSING?

    OpenAIRE

    Swaminathan, Padma V.; Hertel, Thomas W.; Brockmeier, Martina

    1997-01-01

    This paper quantifies the potential impact of European Union enlargement and the consequences of ignoring the non-agricultural component of this integration. We find that agriculture-focused studies offer sound estimates of agriculture-specific production and trade changes, but the estimates of trade volume changes, and welfare gains are far too low.

  4. Introduction: Democratization, Collective Identity Formation, and the EU Enlargement

    Czech Academy of Sciences Publication Activity Database

    Trenz, H.; Mansfeldová, Zdenka; Guasti, Petra; Hronešová, J.

    Praha: Sociologický ústav AV ČR, v.v.i, 2011 - (Guasti, P.; Hronešová, J.; Mansfeldová, Z.), s. 11-25 ISBN 978-80-7330-198-9 Institutional research plan: CEZ:AV0Z70280505 Keywords : collective identity * EU enlargement * democratisation Subject RIV: AD - Politology ; Political Sciences

  5. Income, Deprivation and Economic Stress in the Enlarged European Union

    Science.gov (United States)

    Whelan, Christopher T.; Maitre, Bertrand

    2007-01-01

    At risk of poverty indicators based on relative income measures suggest that within the enlarged EU societies located at quite different points on a continuum of affluence have similar levels of poverty. Substantial differences in levels of income between societies do not in themselves invalidate this approach. However, the relative income…

  6. [Serous cystadenoma of the pancreas showing enlargement on images: a case report].

    Science.gov (United States)

    Nakamoto, Mitsuhiro; Minagawa, Noritaka; Yamaguchi, Koji

    2012-06-01

    Serious Cystadenoma (SCA) of the Pancreas is seldom malignant and is usually monitored over time. Here we report a case of SCA an enlarged cyst that had to be excised because it was difficult to diagnose by intraductal papillary-mucinous neoplasm (IPMN). The patient was a 58-year-old woman with thecoma of the right ovary accompanied by Meigs syndrome, who had undergone abdominal total hysterectomy and bilateral oophorectomy. Abdominal computed tomography scan (CT) showed a multilocular cyst 2.4 cm in diameter in the head of the pancreas. Fourteen months later, a periodic CT showed that the multilocular cyst had enlarged from 2.4 to 3.5 cm in diameter. Branch duct intraductal papillary-mucinous neoplasm (IPMN) with a tendency to enlargement and with mural nodule was suspected. Pylorus-preserving pancreatoduodenectomy (PPPD) was performed, and pathological findings revealed that the cyst was lined with a single layer of simple cuboidal epithelium. Periodic acid-Shiff staining, with and without diastase digestion, showed abundant glycogen within epithelial cells, yielding a definitive diagnosis of SCA. The ascites were probably due to the Meigs syndrome pressing the cyst, and the size of the cyst appeared smaller than the real size. PMID:22768427

  7. EU Enlargement, Identity and the Analysis of European Foreign Policy: Identity Formation through Policy Practice

    OpenAIRE

    Sedelmeier, Ulrich

    2003-01-01

    The eastern enlargement of the EU provides an excellent vantage point to examine the interplay of EU identity and European foreign policy. Yet most analysis of eastern enlargement either focus on enlargement as a case of EU foreign policy or on enlargement as the result of EU norms and identity. They therefore neglect that the EU's enlargement policy practice itself is a case of EU identity formation that has a causal impact on European foreign policy. This paper argues that the EU's eastern ...

  8. Phenytoin, folic acid and gingival enlargement: Breaking myths

    Directory of Open Access Journals (Sweden)

    Abhishek Singh Nayyar

    2014-01-01

    Full Text Available Background: Epilepsy is described as a chronic neurological disorder characterized by recurrent seizures of cerebral origin, presenting with episodes of sensory, motor or autonomic phenomenon with or, without loss of consciousness. A recent meta-analysis of published and unpublished studies puts an overall prevalence rate of epilepsy in India at 5.59 per 1,000 populations.There have been studies that report clinical benefits of the use of folic acid as an adjuvant to the anti-epileptic therapy in the prevention of anti-epileptic drug induced gingival enlargement. However, studies conducted in the past have also reported precipitation of epileptic attacks in patients on folic acid adjuvant therapy due to fall in sera levels of phenytoin due to drug interactions. The study was planned to investigate the association of phenytoin induced gingival enlargement and sera levels of folic acid in epileptic patients on phenytoin therapy so as to justify the use of folic acid as a routine adjuvant to the usual anti-epileptic therapy to prevent this inevitable adverse effect without destabilizing the ongoing regimen leading to the precipitation of seizures in an otherwise stable patient (breakthrough seizures. Materials and Methods: A total of 100 patients between the ages 18 and 50 years were clinically diagnosed with epilepsy prior to the start of phenytoin therapy were included based on selection criteria and written informed consents were obtained. Assessment of serum folic acid levels and gingival enlargement was performed prior to the start of and after 1 year of phenytoin therapy. Statistical Analysis Used: The statistical analysis was carried out using t-test and the baseline serum folate levels and the serum folate levels obtained after 1 year of phenytoin therapy were correlated with the respective grades of gingival enlargement using Pearson′s coefficient formula. Results: The results of the study confirmed a significant association between low

  9. Phenytoin, folic acid and gingival enlargement: Breaking myths

    Science.gov (United States)

    Nayyar, Abhishek Singh; Khan, Mubeen; Vijayalakshmi, K. R.; Suman, B.; Subhas, G. T.; Nataraju, B.; Anitha, M.

    2014-01-01

    Background: Epilepsy is described as a chronic neurological disorder characterized by recurrent seizures of cerebral origin, presenting with episodes of sensory, motor or autonomic phenomenon with or, without loss of consciousness. A recent meta-analysis of published and unpublished studies puts an overall prevalence rate of epilepsy in India at 5.59 per 1,000 populations. There have been studies that report clinical benefits of the use of folic acid as an adjuvant to the anti-epileptic therapy in the prevention of anti-epileptic drug induced gingival enlargement. However, studies conducted in the past have also reported precipitation of epileptic attacks in patients on folic acid adjuvant therapy due to fall in sera levels of phenytoin due to drug interactions. The study was planned to investigate the association of phenytoin induced gingival enlargement and sera levels of folic acid in epileptic patients on phenytoin therapy so as to justify the use of folic acid as a routine adjuvant to the usual anti-epileptic therapy to prevent this inevitable adverse effect without destabilizing the ongoing regimen leading to the precipitation of seizures in an otherwise stable patient (breakthrough seizures). Materials and Methods: A total of 100 patients between the ages 18 and 50 years were clinically diagnosed with epilepsy prior to the start of phenytoin therapy were included based on selection criteria and written informed consents were obtained. Assessment of serum folic acid levels and gingival enlargement was performed prior to the start of and after 1 year of phenytoin therapy. Statistical Analysis Used: The statistical analysis was carried out using t-test and the baseline serum folate levels and the serum folate levels obtained after 1 year of phenytoin therapy were correlated with the respective grades of gingival enlargement using Pearson's coefficient formula. Results: The results of the study confirmed a significant association between low serum folate levels

  10. Enlargement of the European Union and agricultural policy reform

    DEFF Research Database (Denmark)

    Jensen, Maria Skovager; Lind, Kim Martin Hjorth; Zobbe, Henrik

    2009-01-01

    A connection exists between enlargement of the European Union and reforms of the Common Agricultural Policy (CAP). Based upon rational choice theory, we examine whether the member states’ CAP positions are related to structures in their agricultural sectors. The overall hypothesis is that...... intensiveness of agricultural production corresponds to the willingness to reform the CAP. Political CAP positions, together with the development of member states’ structural fundamentals, are analysed using cluster analysis. The results show that EU enlargements have extensified agricultural production at the...... EU level, and that extensive agricultural production in a member state is often an indicator of reduced willingness to reform. However, the intensiveness of agricultural production is only part of the explanation. Moreover, negotiation tactics play an important role for the positions on the CAP....

  11. A STRAINED EUROPEAN MODEL. IS EASTERN ENLARGEMENT TO BLAME?

    Directory of Open Access Journals (Sweden)

    Daniel Daianu

    2007-04-01

    Full Text Available As anticipated, the recent enlargement has put considerable pressure on the European construction, as most of the EU15 member countries are economically and socially strained and policy-makers have a very hard time in devising proper answers to society’s ills. The paper examines various factors which have strained the European Social Model and which, arguably, make this period of Euro-pessimism quite peculiar. It looks at the race for competitiveness in today’s world and the economic rise of Asia; it looks at some inner dynamics in the European societies (demographics, the crisis of the welfare state, a sort of decadence and it tries to explore what lies ahead, including policy options. An underlying thesis herein is that eastern enlargement is not the culprit for the current pains of the EU member countries, though it may have accentuated some.

  12. Old 'foundations' and new 'rules' - For an enlarged European Union

    Directory of Open Access Journals (Sweden)

    José I. Torreblanca

    1997-04-01

    Full Text Available This paper presents a novel arrangement for the distribution of votes and the rules of decision-making in an enlarged European Union (EU. We make two assumptions: (1 that the EU is condemned to enlarge its membership in the near future; and (2 if it does this without changing the existing rules for voting in the Council of Ministers and distributing seats in the European Parliament, such an expanded EU would suffer severe distortions and disequilibria. However, if it were to adopt a new, simplified system that would combine arrangements for proportional proportionality in representation and concurrent majorities in decision-making, this impending dilemma could be avoided. Moreover, if these reforms were introduced sooner rather than later, they would be easier to agree upon, their impact would be phased in gradually, and their legitimacy could be stabilized in the face of far greater challenges in the future.

  13. The dilemmas of tax coordination in the enlarged European Union

    DEFF Research Database (Denmark)

    Brøchner, Jens; Jensen, Jesper; Svensson, Patrik;

    2007-01-01

    increased the potential gains from tax harmonization, provided corporate tax rates and tax bases are harmonized at their unweighted averages. (ii) All scenarios for coordination leave some EU Member States as winners and others as losers. An agreement on tax coordination is therefore likely to require......This study evaluates the economic effects of corporate tax coordination in the enlarged European Union (EU) using a computable general equilibrium model. Our main findings are as follows: (i) Corporate tax coordination can yield modest aggregate welfare gains. The 2004 enlargement of the EU has...... elaborate compensation mechanisms. (iii) The large and diverse country effects suggest that Enhanced Cooperation for a subset of the Member States may be the most likely route towards tax coordination. (iv) Identifying winners and losers from coordination for the purpose of a compensation mechanism may be...

  14. Enlargement of the bony orbit by orbital recurrence of choroidal melanoma 21 years after enucleation

    OpenAIRE

    Simonsz, Huib; Löffler, Karin

    1992-01-01

    textabstractA case is presented of a 58-year-old retarded male with a 6 cm, painless, hard, pigmented tumor filling the left orbit completely, after enucleation 21 years previously for retinal detachment, glaucoma and no light perception. CT scan and MRI revealed, besides the tumor, an outspoken enlargement of the bony orbit with thinning of the orbital walls. A biopsy showed a spindle B cell melanoma. In one of the paraffin histology sections of the globe enucleated 21 years previously a ver...

  15. Non-Hodgkin's lymphoma presenting with uterine and renal enlargement in a young girl

    International Nuclear Information System (INIS)

    Non-Hodgkin's lymphoma (NHL) is the fourth most common childhood malignancy. Uterine involvement with NHL is well described in adults, rare in children and has not been described in the first 2 years of life. While renal involvement in NHL is well recognised, diffuse renal enlargement is an uncommon finding. We report a unique case of B-cell lymphoma of primitive phenotype in a 15-month-old girl with uterine and renal involvement at presentation. We describe the US and MRI features at presentation that helped in the prospective diagnosis of this condition. (orig.)

  16. Non-Hodgkin's lymphoma presenting with uterine and renal enlargement in a young girl

    Energy Technology Data Exchange (ETDEWEB)

    Moon, L.D.; Brenner, C.; McHugh, K.; DeBruyn, R. [Dept. of Radiology, Great Ormond Street Hospital for Children NHS Trust, London (United Kingdom); Ancliff, P. [Dept. of Host Defence, Great Ormond Street Hospital for Children NHS Trust, London (United Kingdom)

    2004-03-01

    Non-Hodgkin's lymphoma (NHL) is the fourth most common childhood malignancy. Uterine involvement with NHL is well described in adults, rare in children and has not been described in the first 2 years of life. While renal involvement in NHL is well recognised, diffuse renal enlargement is an uncommon finding. We report a unique case of B-cell lymphoma of primitive phenotype in a 15-month-old girl with uterine and renal involvement at presentation. We describe the US and MRI features at presentation that helped in the prospective diagnosis of this condition. (orig.)

  17. Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea

    OpenAIRE

    Boote, Craig; Hayes, Sally; Robert D. Young; Kamma-Lorger, Christina S.; Hocking, Paul M.; Elsheikh, Ahmed; Inglehearn, Chris F.; Ali, Manir; Meek, Keith M.

    2009-01-01

    In the cornea, the precise organisation of fibrillar collagen and associated proteoglycans comprising the stromal extracellular matrix plays a major role in governing tissue form and function. Recently, abnormal collagen alignment was noted in the misshapen corneas of mature chickens affected by the retinopathy, globe enlarged (rge) mutation. Here we further characterize corneal ultrastructural changes as the rge eye develops post-hatch. Wide-angle X-ray scattering disclosed alteration to dom...

  18. Childhood asymmetrical labium majus enlargement sonographic and MR imaging appearances

    Energy Technology Data Exchange (ETDEWEB)

    Gokli, Ami; Neuman, Jeremy; Lukse, Ruby; Koshy, June [Staten Island University Hospital, Department of Radiology, Staten Island, NY (United States); Kong, Fanyi [Staten Island University Hospital, Department of Pathology, Staten Island, NY (United States); Laor, Tal [Cincinnati Children' s Hospital Medical Center, Department of Radiology, Cincinnati, OH (United States)

    2016-05-15

    Childhood asymmetrical labium majus enlargement (CALME) has been described sparsely in recent surgery, pathology, pediatric and gynecology literature; however, no comprehensive description from a radiology perspective has been developed. The purpose of this case series is to describe the imaging findings of CALME and to review the current understanding of this recently described clinical entity with regard to clinical presentation, pathophysiology, differential diagnosis and treatment options. This is a retrospective analysis of 3 girls, ages 5-7 years, who presented for imaging evaluation with subsequent pathologically proven CALME. Each child's clinical history, length of symptoms, imaging appearance and pathological findings were reviewed. All three girls presented with unilateral enlargement of the labium majus (two right-side, one left-side) with no history of trauma or other inciting cause. Two girls had painless labial enlargement that was recognized for weeks, and one had similar symptoms for 1 year prior to presentation. One girl was evaluated initially with sonography, and all three children underwent MR imaging. Sonographic evaluation showed asymmetrical labial enlargement without a definable mass. In each girl, the MR imaging findings were characterized by relatively ill-defined T1-weighted hypointense signal, T2-weighted hypo- to isointense signal with interspersed hyperintense septae, and heterogeneous patchy and feathery strands of enhancement on post-contrast imaging. Biopsy from each child showed benign fibrous tissue with intervening mature fibroadipose tissue, vessels and nerves without findings of inflammation or neoplasia. The MR imaging appearance of CALME is consistent. Recognition and appreciation of this unique pediatric entity by the radiologist may be essential for appropriate diagnosis and can help to guide therapy. Current preferred treatment approach is conservative. (orig.)

  19. Cytomorphologic significance of marginal vacuoles in diffuse thyroid enlargements

    OpenAIRE

    Anshu Gupta; Manish Singhal; Shivani Kalhan; Atul Gupta; Onis Singhal; Viplesh Kaur

    2013-01-01

    Background: Fine needle aspiration cytology (FNAC) of the thyroid is an established first-line test for thyroid lesions. Marginal vacuoles (MVs) have been associated with hyperactivity of the thyroid, but some studies have pointed towards their nonspecific status. Aims: To assess the presence of MVs in diffuse thyroid enlargements and evaluate the strength of correlation between MVs, levels of thyroid hormone and cytological diagnosis. Materials and Methods: Ninety-seven cases of diff...

  20. The sustainability of the Barcelona port enlargement works

    OpenAIRE

    Tarragó, D.; Gens Solé, Antonio; Alonso Pérez de Agreda, Eduardo; Romero Morales, Enrique Edgar; Griell, R.; Estrada, J.L.; Uzcanga, J.

    2011-01-01

    In the Barcelona Port enlargement, currently under construction, part of the new quays are being backfilled with re-used materials such as tunneling waste, rubble from demolitions and dredged soils with poor geotechnical properties. This has resulted in a cost-effective and sustainable construction process that is one of the main goals of the Barcelona Port Authority (APB). A series of control tests have been carried out on the mentioned materials. In addition, dredged soils have been impr...

  1. Malignant Mesothelioma Presenting as a Gradually Enlarging Pneumothorax

    OpenAIRE

    Ashish Prasad; Diana Olsen; Sriram, P. S.

    2013-01-01

    Malignant mesothelioma is an extremely aggressive tumor arising from the pleura with median survival of approximately 9–12 months. It can rarely present as a spontaneous pneumothorax. Less than 35 cases of malignant mesothelioma presenting as spontaneous pneumothorax have been reported in the literature. Pathology may show florid mesothelial hyperplasia. We herein report a case of mesothelioma presenting as a pneumothorax that gradually enlarged over a one-year period and also review the rele...

  2. Childhood asymmetrical labium majus enlargement sonographic and MR imaging appearances

    International Nuclear Information System (INIS)

    Childhood asymmetrical labium majus enlargement (CALME) has been described sparsely in recent surgery, pathology, pediatric and gynecology literature; however, no comprehensive description from a radiology perspective has been developed. The purpose of this case series is to describe the imaging findings of CALME and to review the current understanding of this recently described clinical entity with regard to clinical presentation, pathophysiology, differential diagnosis and treatment options. This is a retrospective analysis of 3 girls, ages 5-7 years, who presented for imaging evaluation with subsequent pathologically proven CALME. Each child's clinical history, length of symptoms, imaging appearance and pathological findings were reviewed. All three girls presented with unilateral enlargement of the labium majus (two right-side, one left-side) with no history of trauma or other inciting cause. Two girls had painless labial enlargement that was recognized for weeks, and one had similar symptoms for 1 year prior to presentation. One girl was evaluated initially with sonography, and all three children underwent MR imaging. Sonographic evaluation showed asymmetrical labial enlargement without a definable mass. In each girl, the MR imaging findings were characterized by relatively ill-defined T1-weighted hypointense signal, T2-weighted hypo- to isointense signal with interspersed hyperintense septae, and heterogeneous patchy and feathery strands of enhancement on post-contrast imaging. Biopsy from each child showed benign fibrous tissue with intervening mature fibroadipose tissue, vessels and nerves without findings of inflammation or neoplasia. The MR imaging appearance of CALME is consistent. Recognition and appreciation of this unique pediatric entity by the radiologist may be essential for appropriate diagnosis and can help to guide therapy. Current preferred treatment approach is conservative. (orig.)

  3. Pallidum and lateral ventricle volume enlargement in autism spectrum disorder.

    Science.gov (United States)

    Turner, Andia H; Greenspan, Kiefer S; van Erp, Theo G M

    2016-06-30

    Studies on structural brain abnormalities in individuals with autism spectrum disorders (ASD) have been of limited size and many findings have not been replicated. In the largest ASD brain morphology study to date, we compared subcortical, total brain (TBV), and intracranial (ICV) volumes between 472 subjects with DSM-IV ASD diagnoses and 538 healthy volunteers (age range: 6-64 years), obtained from high-resolution structural brain scans provided by the Autism Brain Imaging Data Exchange (ABIDE). Compared to healthy volunteers, we found significantly larger pallidum (Cohen's d=0.15) and lateral ventricle volumes (Cohen's d=0.18) in ASD. These enlargements were independent of total brain volume and IQ, passed FDR correction for multiple comparisons, and were observed in overall, male-only, and medication-free subjects. In addition, intracranial, hippocampal, and caudate volumes were enlarged in ASD at a nominal statistical threshold of p<0.05. This study provides the first robust evidence for pallidum enlargement in ASD independent from TBV and encourages further study of the functional role of the pallidum in individuals with autism spectrum disorder. PMID:27179315

  4. 'P' mitrale and left atrial enlargement: comparison with echocardiography

    International Nuclear Information System (INIS)

    This study was carried out to determine the sensitivity and specificity of 'P' Mitrale in diagnosing left atrial enlargement by comparing it with the Gold Standard of echocardiography. The study was carried out at the department of Physiology, Army Medical College, Rawalpindi and department of Cardiology at Armed Forces Institute of Cardiology / National Institute of Heart Diseases. 50 clinically diagnosed cases of left atrial enlargement were included in the study. ECG of the patients was recorded and 'P' Mitrale observed. This was followed by echocardiography and using 2-D echocardiogram as a guideline M-mode recording was obtained and left atrial size was calculated. 'P' Mitrale has a sensitivity of 22.5% and specificity of 100%. The positive and negative predictive value and diagnostic efficacy of the test were also calculated. Sensitivity of ECG is low in detecting left atrial enlargement. However its sensitivity can be increased by combining 'P' Terminal Force in lead V1 and P/P-R ratio to 'P' Mitrale. ECG is however still recommended as a routine investigation because of its cost effectiveness and easy availability. (author)

  5. Western Balkan States and the European Union Enlargement

    Directory of Open Access Journals (Sweden)

    Gelina Maliqi (Ramolli

    2011-07-01

    Full Text Available For half a century, European Union-(EU has pursued ever-deeper integration while taking in new members. It’s marked as an important step in relationship deepening between EU and Western Balkans-(WBs where Albania is part of. In 2003, EU declared that the future of WBs is within EU. Initially it adopted a generous strategy that linked the timetable for accession to the pace of reform in WBs. The declaration contained a conditional promise; EU would consider WBs for membership only if they reached EU standards. The EU was motivated by usual economic considerations connected to enlargement and a desire to increase regional stability. The enlargement process regarding Albania will bring several reforms on different fields. Our country will benefit from a share of multibeneficiary funds for competitiveness, SMEs, energy efficiency and banking sector regulation. This presentation handles out these main issues: EU policy and the enlargement process regarding Albania inspecting the way and progress done up to now by our country, the main features of our national EUcoordination system, concluding in a SWOT Analysis of EU-coordination system in Albania. Eventually, I believe that Albania being part of WBs is at one time an opportunity and a challenge for the future of EU.

  6. Stochastic Schrödinger evolution over piecewise enlarged filtrations

    Science.gov (United States)

    Mengütürk, Levent Ali

    2016-03-01

    This paper constructs a nonlinear filtering framework that admits appearances of new information processes at random times by introducing piecewise enlargements of filtrations and proposes a new energy-based Schrodinger evolution expressed as a stochastic differential equation on a complex Hilbert space. Each information process is modeled as the sum of a random variable taking the eigenvalues of a Hamiltonian and an independent Brownian bridge noise. It is shown that under a piecewise enlarged filtration, the wave function is a jump-diffusion process until it collapses at some terminal time. In between discontinuities, the dynamics of the state vector are governed by different Wiener processes and diffusion coefficients. This motivates the introduction of an inclusive chain of Kolmogorov probability spaces or a *-isomorphic chain of commutative von Neumann probability spaces, on which the quantum system evolves differently based on the number of active information processes. The expectation of the Hamiltonian at a given state is the solution of a second-order nonlinear differential equation determined by one of the possible regimes that the quantum system belongs to. It is shown that the collapse rate is a submartingale with positive jumps and the Shannon entropy process is a supermartingale with expected negative jumps when passing to higher-order probability spaces. The framework is extended to the case when the Hamiltonian is modeled as a function of a set of commutative operators, where each operator is associated with a different piecewise enlarged filtration.

  7. Who Wants Enlargement of the EU? Support for Enlargement among Elites and Citizens in the European Union

    OpenAIRE

    Nissen, Sylke

    2003-01-01

    A collective European identity is often mentioned as important for the European Union's future. The article discusses common definitions of collective identity & proposes to add a utilitarian component to the concept. In this respect, political solidarity &, particularly, interest in & support for the coming Eastern enlargement are taken as an indicator of European identity. As a starting point for further discussion on the structure & necessity of European identity, the article examines enla...

  8. Sodium valproate induced gingival enlargement with pre-existing chronic periodontitis

    Directory of Open Access Journals (Sweden)

    Vaibhavi Joshipura

    2012-01-01

    Full Text Available Gingival enlargement is a common clinical feature of gingival and periodontal diseases. Currently, more than 20 prescription medications are associated with gingival enlargement. Although the mechanisms of action may be different, the clinical and microscopic appearance of drug-induced gingival enlargement is similar with any drug. Gingival enlargement produces esthetic changes, and clinical symptoms including pain, tenderness, bleeding, speech disturbances, abnormal tooth movement, dental occlusion problems, enhancement of caries development and periodontal disorders. Sodium valproate is considered to produce gingival enlargement, but very rarely. This case report features sodium valproate induced gingival enlargement in a patient with pre-existing chronic periodontitis, who came to the Dental Department, Chinmaya Mission Hospital, Bangalore. The case is special as the patient did not develop the enlargement in spite of taking phenytoin for 1 year and developed enlargement with sodium valproate within 6 months.

  9. Inheritance of enlarged leaf mutations in pea (Pisum sativum L.)

    International Nuclear Information System (INIS)

    In the present study, two pea (Pisum sativum L.) mutants experimentally obtained after gamma irradiation of dry seeds are described. Both mutants were characterized by enlarged leaf size. The mutant 2/462 was shown to have semi-dominant inheritance pattern; 2/927 was sterile and inherited monogenic recessive. The induced mutations have pleiotropic effect, affecting morphological and reproductive traits. New mutants had similar phenotypes to previously named mutants latifolium (lat) and cabbage leaf (calf), but no allelism tests were made between the new and the previously reported mutants. Both mutant lines may be useful plant material for research on leaf development

  10. MRI of enlarged dorsal ganglia, lumbar nerve roots, and cranial nerves in polyradiculoneuropathies

    International Nuclear Information System (INIS)

    This paper describes the MRI findings in four patients with a clinical diagnosis of hypertrophic polyradiculoneuropathies. In two examination of the lumbar spine showed enlarged nerve roots and dorsal ganglia, and similar findings were present in the cervical spine in a third. The cisternal portions of the cranial nerves were enlarged in another patient. MRI allows identification of enlarged nerves in hypertrophic polyradiculopathies. (orig.)

  11. Western Balkan States and the European Union Enlargement

    Directory of Open Access Journals (Sweden)

    Gelina Maliqi (Ramolli,

    2011-06-01

    Full Text Available For half a century, European Union-(EU has pursued ever-deeper integration while takingin new members. It’s marked as an important step in relationship deepening between EU and WesternBalkans-(WBs where Albania is part of. In 2003, EU declared that the future of WBs is within EU.Initially it adopted a generous strategy that linked the timetable for accession to the pace of reform inWBs. The declaration contained a conditional promise; EU would consider WBs for membership onlyif they reached EU standards. The EU was motivated by usual economic considerations connected toenlargement and a desire to increase regional stability. The enlargement process regarding Albaniawill bring several reforms on different fields. Our country will benefit from a share of multibeneficiaryfunds for competitiveness, SMEs, energy efficiency and banking sector regulation. Thispresentation handles out these main issues: EU policy and the enlargement process regarding Albaniainspecting the way and progress done up to now by our country, the main features of our national EU coordinationsystem, concluding in a SWOT Analysis of EU-coordination system in Albania.Eventually, I believe that Albania being part of WBs is at one time an opportunity and a challenge forthe future of EU.

  12. Enlarged tongue due to primary systemic amyloidosis:clinicopathologic observation

    Institute of Scientific and Technical Information of China (English)

    潘卫红; 李娜萍; 梁国芬

    2004-01-01

    @@Primary amyloidosis (AL) is characterized by deposition of abnormal extra cellular protein in the form of fibrils in many organs, especially the heart, kidneys, gastrointestinal tract, and peripheral nervous system.1 Involvement of the tongue is not uncommon in primary AL. In 22 % to 26 % of patients suffering from AL, amyloid deposition in the tongue can result in an enlarged tongue.2 Lingual changes arising from localization or from all over, AL has been reported frequently as initial signs of the disease. Macroscopically, it is difficult to distinguish AL of the tongue from other lesions. In view of the variety of protein species involved and the wide spectrum of possible clinical presentations,3 the diagnosis of lingual AL is frequently overlooked, because immunohistochemical studies of such cases have not been undertaken. Here we describe two male patients with primary systemic AL who developed enlarged tongues. In addition to the manifestation of lingual AL, in which oral signs were the primary indicators of the disease, we describe the immunohistochemical findings of the tongue to discuss diagnostic criteria for lingual amyloid in primary AL.

  13. CHANGING FROM WITHIN? THE INTRA-ORGANIZATIONAL DYNAMICS OF EU ENLARGEMENT

    Directory of Open Access Journals (Sweden)

    Velibor JAKOVLESKI

    2015-12-01

    Full Text Available This paper opens up the black box of enlargement, focusing on how the intra-organizational relationships among the Council of the European Union, the European Commission, and the European Parliament affect the process of enlargement. Formally speaking, enlargement is an intergovernmental process, suggesting that member states are firmly in control of its outcomes. However, the EU’s supranational actors, specifically the European Parliament and European Commission also attempt to influence enlargement at various stages. I posit that the process of enlargement to the Western Balkans has evolved, influenced by changing constraints which are operating on the aforementioned actors. The added value of this work is in disaggregating the enlargement process based on its institutionalized relationships in both a vertical and horizontal dimension. It provides a supply-side argument for how enlargement policy has evolved from within the EU, rather than simply as a function of external factors.

  14. Random times and enlargements of filtrations in a Brownian setting

    CERN Document Server

    Mansuy, Roger

    2006-01-01

    In November 2004, M. Yor and R. Mansuy jointly gave six lectures at Columbia University, New York. These notes follow the contents of that course, covering expansion of filtration formulae; BDG inequalities up to any random time; martingales that vanish on the zero set of Brownian motion; the Azéma-Emery martingales and chaos representation; the filtration of truncated Brownian motion; attempts to characterize the Brownian filtration. The book accordingly sets out to acquaint its readers with the theory and main examples of enlargements of filtrations, of either the initial or the progressive kind. It is accessible to researchers and graduate students working in stochastic calculus and excursion theory, and more broadly to mathematicians acquainted with the basics of Brownian motion.

  15. Uptake of thallium-201 in enlarged thyroid glands. Concise communication

    Energy Technology Data Exchange (ETDEWEB)

    Fukuchi, M.; Kido, A.; Hyodo, K.; Tachibana, K.; Onoue, K.; Morita, T.; Nagai, K.

    1979-08-01

    We have investigated the thyroid uptake of Tl-201 in 37 patients with various types of goiter, and in six with normal thyroids. Significant thallium uptake was found in all cases in which there was thyroid enlargement, including Graves' disease, toxic thyroid nodule, primary hypothyroidism, simple goiter, Hashimoto's disease, thyroid carcinoma, and thyroid adenoma. If goiter was absent, however, there was no demonstrable uptake - e.g., in secondary hypothyroidism, subacute thyroiditis, and the normal controls. Thallium uptake did not correlate with thyroid function tests such as BMR, T/sub 3/-RU, T/sub 3/, T/sub 4/, TSH, antithyroid antibodies, or the 24-hr I-131 uptake. In 23 patients with diffuse goiter, on the other hand, maximum Tl-201 uptake correlated well with thyroid weight: r = 0.836 (p < 0.001); y = 0.02 x + 0.06.

  16. Aerodynamic Analysis of Trailing Edge Enlarged Wind Turbine Airfoils

    DEFF Research Database (Denmark)

    Xu, Haoran; Shen, Wen Zhong; Zhu, Wei Jun; Yang, Hua; Liu, Chao

    2014-01-01

    The aerodynamic performance of blunt trailing edge airfoils generated from the DU- 91-W2-250, DU-97-W-300 and DU-96-W-350 airfoils by enlarging the thickness of trailing edge symmetrically from the location of maximum thickness to chord to the trailing edge were analyzed by using CFD and RFOIL...... methods at a chord Reynolds number of 3 × 106. The goal of this study is to analyze the aerodynamic performance of blunt trailing edge airfoils with different thicknesses of trailing edge and maximum thicknesses to chord. The steady results calculated by the fully turbulent k-ω SST, transitional k-ω SST...... model and RFOIL all show that with the increase of thickness of trailing edge, the linear region of lift is extended and the maximum lift also increases, the increase rate and amount of lift become limited gradually at low angles of attack, while the drag increases dramatically. For thicker airfoils...

  17. Enlarged parietal foramina: a rare forensic autopsy finding.

    Science.gov (United States)

    Durão, Carlos; Carpinteiro, Dina; Pedrosa, Frederico; Machado, Marcos P; Cunha, Eugénia

    2016-05-01

    Enlarged parietal foramina (EPF) are a quite rare developmental defect of the parietal bone which has to be distinguished from the normal small parietal foramina. We report a forensic case of an individual found in an advanced state of putrefaction in his own house with an undetermined cause of death. No evidence of trauma was observed, and the toxicological exam was negative. The victim was a 40-year-old man with a history of epilepsy. The large biparietal foramina, a rare anatomical variation and unusual autopsy finding, were observed at autopsy. The recognition of anatomical variations is important to avoid false interpretations and conclusions and has a significant potential as an identity factor, thus contributing to positive identification. PMID:26233611

  18. Drug-associated gingival enlargement in pediatric patients

    Directory of Open Access Journals (Sweden)

    Nowzari H.

    2009-03-01

    Full Text Available "nGingival overgrowth is a drug-associated side effect occurs in pediatric patients. Phenytoin, cyclosporine, calcium channel blockers, and amphetamine are primary drugs that can cause gingival enlargement in children. Pediatric patients are more prone to drug-associated gingival overgrowth rather than adults. Gingival overgrowth may cause functional, phonetic, and nutritional difficulties, and more importantly, may affect the psycho-social development, self-esteem, and quality of life in children. However, the researches about this issue are rare. This Part I paper provides an analysis of pediatric systemic disease and corresponding prescribed medications for selected physical and mental health conditions. This paper describes the morbidity and risk for children related to gingival overgrowth and proposes a framework for action that will be more completely described in a part II paper on this topic.

  19. A Digitally Programmable Differential Integrator with Enlarged Time Constant

    Directory of Open Access Journals (Sweden)

    S. K. Debroy

    1994-12-01

    Full Text Available A new Operational Amplifier (OA-RC integrator network is described. The novelties of the design are used of single grounded capacitor, ideal integration function realization with dual-input capability and design flexibility for extremely large time constant involving an enlargement factor (K using product of resistor ratios. The aspect of the digital control of K through a programmable resistor array (PRA controlled by a microprocessor has also been implemented. The effect of the OA-poles has been analyzed which indicates degradation of the integrator-Q at higher frequencies. An appropriate Q-compensation design scheme exhibiting 1 : |A|2 order of Q-improvement has been proposed with supporting experimental observations.

  20. Compact lensless digital holographic microscopy using a curved mirror for an enlarged working distance.

    Science.gov (United States)

    Shi, Ervin Cheng; Ng, Joshua Jeremiah; Lim, Choo Min; Qu, Weijuan

    2016-05-10

    Digital holographic microscopy (DHM) has a wide range of applications from the analysis of microelectronic mechanical systems (MEMS) to the measurement of cells. We intend on making the system more compact to improve the portability of the device. A concave mirror has been presented to be used in a lensless DHM system to effectively enlarge the working distance and at the same time maintain the compact size of the whole system. A theoretical analysis of the phase compensation between the object wave and the wave reflected from curved reference mirrors is given. Experimental demonstrations of the curved reference mirrors used in the DHM system have been obtained to support our idea. This would change the overall size and adaptability of the DHM system and provide a better understanding of the effects of phase reflected off a curved mirror. PMID:27168290

  1. Accuracy of electrocardiographic criteria for atrial enlargement: validation with cardiovascular magnetic resonance

    OpenAIRE

    Manning Warren J; Agarwal Anupam; O'Halloran T David; Hauser Thomas H; Josephson Mark E; Tsao Connie W; Yeon Susan B

    2008-01-01

    Abstract Background Anatomic atrial enlargement is associated with significant morbidity and mortality. However, atrial enlargement may not correlate with clinical measures such as electrocardiographic (ECG) criteria. Past studies correlating ECG criteria with anatomic measures mainly used inferior M-mode or two-dimensional echocardiographic data. We sought to determine the accuracy of the ECG to predict anatomic atrial enlargement as determined by volumetric cardiovascular magnetic resonance...

  2. The Fourth Enlargement of the European Union: Austria, Finland, and Sweden Join the EU

    OpenAIRE

    Fritz Breuss

    1995-01-01

    The integration of the rich EFTA countries Austria, Finland, and Sweden into the EU shifts the center of gravity to the North. While the previous enlargement by the "cohesion" countries Greece, Portugal, and Spain was a burden on the budget of the EU, the present enlargement is a relief. The integration of the three neutral countries constitutes no economic problems, but progress in the area of collective security might possibly be slowed down by their accession. Through the fourth EU enlarge...

  3. The Post-enlargement European Order: Europe ‘United in Diversity’?

    OpenAIRE

    Paul Blokker

    2006-01-01

    The enlargement of the European Union has led to an increase of diversity within the European area. While the project of enlargement can be understood as one in which the European Union has sought to defend an exclusive understanding of European identity (a ‘Fortress Europe’), the combined process of enlargement and constitutionalisation can be seen to have ultimately contributed to an opening up as well as a rendering more contingent of the European project. The theoretical argument of the p...

  4. CHANGING FROM WITHIN? THE INTRA-ORGANIZATIONAL DYNAMICS OF EU ENLARGEMENT

    OpenAIRE

    Velibor JAKOVLESKI

    2015-01-01

    This paper opens up the black box of enlargement, focusing on how the intra-organizational relationships among the Council of the European Union, the European Commission, and the European Parliament affect the process of enlargement. Formally speaking, enlargement is an intergovernmental process, suggesting that member states are firmly in control of its outcomes. However, the EU’s supranational actors, specifically the European Parliament and European Commission also attempt to influence enl...

  5. Gingival Enlargement in a Case of Variant Jones Syndrome: a Case Report

    Science.gov (United States)

    DA, Roopa; Singh, Shinkhala; Gupta, Ira; Gopal, Saumiya

    2016-01-01

    Gingival enlargement can be caused by a variety of etiological factors like inflammation, drugs, and systemic diseases or can be presented as a part of a syndrome. One such syndrome is Jones Syndrome, which is associated with gingival enlargement and progressive hearing loss. We present here a case of fifteen-year-old boy with gingival enlargement, hearing loss, and generalized alveolar bone loss and diagnosed as Jones syndrome. The diagnosis was made based on history, clinical, radiographic, and histopathological findings. Gingival enlargement was surgically managed using gingivectomy and no recurrence was observed. The patient showed remarkable esthetical and functional improvement. PMID:26966711

  6. A Visible QCD Axion from an Enlarged Color Group

    CERN Document Server

    Gherghetta, Tony; Shifman, Mikhail

    2016-01-01

    We consider the possibility of an enlarged QCD color group, SU(3+$N^\\prime$) spontaneously broken to SU(3)$_c\\times$SU($N^\\prime$)$\\times$U(1)$_X$ with extra vector-like quarks transforming in the fundamental representation. When the heavy quarks are integrated out below the PQ-breaking scale, they generate an axion coupling which simultaneously solves the strong CP problem for both gauge groups. However, the axion mass now receives a new nonperturbative contribution from the SU($N^\\prime$) confinement scale, which can be substantially larger than the QCD scale. This can increase the axion mass to be at or above the electroweak scale. This visible axion can then decay into gluons and photons giving rise to observable signals at Run-II of the LHC. In particular, if the mass is identified with the 750 GeV diphoton resonance then the new confinement scale $\\sim$ TeV and the PQ-breaking scale $\\sim$ 10 TeV. This predicts vector-like quarks and a PQ scalar resonance in the multi-TeV range, with the possibility tha...

  7. In vivo phospholipid biosynthesis in cotton cotyledons during glyoxysome enlargement

    International Nuclear Information System (INIS)

    The surface are of cottonseed glyoxysomes increases about 4 fold within 36 h after imbibition. Membrane phospholipid must become available to glyoxysomes to accommodate expansion. Incubation of cotyledons (18-h-old) in 14C-choline (1 h) resulted in at least 85% recovery of 14C-phosphatidylcholine (PC) in membranes comigrating on sucrose gradients (20-59% w/w) with antimycin A-insensitive cytochrome c reductase (CCR) activity and choline- and ethanolaminephosphotransferase (CPT and EPT) activities (ER at about 24% w/w sucrose). Chase experiments with 3.4 M choline chloride for 2, 12, or 24 h led to increasing proportions of 14C-PC (36% after 24 h) recovery in mitochondria. No transfer of 14C-PC to enlarging glyoxysomes was detected. Incubations in 14C-ethanolamine yielded ER labeling after only 30 min. 14C-PE chased into mitochondria membranes more rapidly than PC (45% after 12 h), and no 14C-PE chased into glyoxysome membranes. Evidence for synthesis of 14C-PC from 14C-PE was found after 12 h chase with 1 M ethanolamine hydrochloride. Our results indicate that ER is the primary site of PC and PE synthesis in vivo and that ER contributes newly synthesized PC and PE to mitochondrial membranes but not to expanding glyoxysomal membranes. This is different from membrane biogenesis of glyoxysomes proliferating in castor bean endosperm

  8. Hydrodynamic drag constrains head enlargement for mouthbrooding in cichlids.

    Science.gov (United States)

    Van Wassenbergh, Sam; Potes, Nuno Zavattieri; Adriaens, Dominique

    2015-08-01

    Presumably as an adaptation for mouthbrooding, many cichlid fish species have evolved a prominent sexual dimorphism in the adult head. Since the head of fishes serves as a bow during locomotion, an evolutionary increase in head volume to brood more eggs can trade-off with the hydrodynamic efficiency of swimming. Here, the differences between males and females in three-dimensional shape and size of the external head surfaces and the effect thereof on drag force during locomotion was analysed for the Nile tilapia (Oreochromis niloticus), a maternal mouthbrooder. To do so, three-dimensional body surface reconstructions from laser scans and computational fluid dynamics simulations were performed. After scaling the scanned specimens to post-cranial body volume, in order to theoretically equalize propulsive power, the external volume of the head of females was 27% larger than that of males (head length + 14%; head width + 9%). These differences resulted in an approximate 15% increase in drag force. Yet, hydrodynamics imposed important constraints on the adaptation for mouthbrooding as a much more drastic drop in swimming efficiency seems avoided by mainly enlarging the head along the swimming direction. PMID:26224567

  9. Nuclear energy - a vote for good sense. 4. enlarged ed.

    International Nuclear Information System (INIS)

    What does Chernobyl mean for the current discussion in the public on nuclear energy and its utilisation in the Federal Republic of Germany - what can it mean, and what should it mean. Is it the memento showing us that we ought to abandon nuclear energy. There are many people who now are prepared to do so; for them, the accident there radically changed the situation here - a conclusion which is far from being logical if one compares the Soviet design of nuclear power stations with our German standards. Chernobyl has raised emotions, but fear must not be the only factor determining the decision about an appropriate utilisation of nuclear energy. This is why this enlarged edition of the third, 1981 edition of 'Nuclear energy - a vote for good sense' is published now, with a preface and three chapters in the annex discussing the Chernobyl accident and its consequences. Surprisingly, the answers given five years ago to queries concerning the safety of the peaceful use of nuclear energy still are the same, and still valid. (orig.)

  10. Enlarged spinoglenoid notch veins causing suprascapular nerve compression

    International Nuclear Information System (INIS)

    To report the magnetic resonance (MR) imaging findings of enlarged veins in the spinoglenoid notch as a cause of suprascapular nerve compression.Design and patients Six patients presented to MR imaging for evaluation of chronic shoulder pain. Clinical information and MR imaging studies were reviewed. The spinoglenoid notch vascular structures were compared with measurements made in 10 age-matched controls. Spinoglenoid notch vascular structures measured in 10 asymptomatic age-matched control patients ranged from 1 to 4 mm in diameter with an average of 2.2 mm. The six study patients had vascular structures that ranged from 6 to 10 mm in diameter with an average of 8.4 mm. Atrophy and fatty infiltration of the infraspinatus muscle was noted as an associated finding at MR imaging in all six patients. Surgery was performed in three of the six patients, at which time a venous varix was identified in the spinoglenoid notch in all three patients. We describe distended veins in the spinoglenoid notch. These may be readily apparent at MR imaging and should be distinguished from paralabral ganglion cysts compressing the suprascapular nerve in the absence of labral tears, especially if percutaneous aspiration of a ganglion cyst is entertained. (orig.)

  11. Enlarged spinoglenoid notch veins causing suprascapular nerve compression

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, Kevin W. [Radiology Regional Center, 700 Goodlette Road, Naples, FL 34102 (United States); Helms, Clyde A. [Duke University Medical Center, Department of Radiology, Box 3808, Durham, NC 27710 (United States); Otte, Michael T. [Invision Medical Imaging and Radiology, 8200 East Belleview Avenue, Suite 124, Greenwood Village, CO 80111 (United States); Moellken, S.M.C. [San Francisco Magnetic Resonance Center, 3333 California Street, Suite 105, San Francisco, CA 94118 (United States); Fritz, R. [National Orthopedic Associates, 1260 South Eliseo Drive, Greenbrae, CA 94904 (United States)

    2003-02-01

    To report the magnetic resonance (MR) imaging findings of enlarged veins in the spinoglenoid notch as a cause of suprascapular nerve compression.Design and patients Six patients presented to MR imaging for evaluation of chronic shoulder pain. Clinical information and MR imaging studies were reviewed. The spinoglenoid notch vascular structures were compared with measurements made in 10 age-matched controls. Spinoglenoid notch vascular structures measured in 10 asymptomatic age-matched control patients ranged from 1 to 4 mm in diameter with an average of 2.2 mm. The six study patients had vascular structures that ranged from 6 to 10 mm in diameter with an average of 8.4 mm. Atrophy and fatty infiltration of the infraspinatus muscle was noted as an associated finding at MR imaging in all six patients. Surgery was performed in three of the six patients, at which time a venous varix was identified in the spinoglenoid notch in all three patients. We describe distended veins in the spinoglenoid notch. These may be readily apparent at MR imaging and should be distinguished from paralabral ganglion cysts compressing the suprascapular nerve in the absence of labral tears, especially if percutaneous aspiration of a ganglion cyst is entertained. (orig.)

  12. Nuclear Energy in the European Union - Before and after enlargement

    International Nuclear Information System (INIS)

    2004 will be a key milestone for the European Union's political and economic development, with the expansion of its membership from 15 to 25 countries. In comparison the changes in the nuclear sector seem small - but they are nevertheless significant. The political changes in 1989 increased public and political concerns over the dangers of nuclear power in Eastern Europe. These concerns led to the closure of all operating reactors in former Eastern Germany following unification, and increased international efforts to close similar reactors in the current accession countries. These attempts only reached fruition as a result of the negotiations for accession to the EU, and the first WWER 440-230 reactors were closed in Bulgaria in 2003. A total of eight reactors in three countries are scheduled for closure by 2010. However, the closure dates finally agreed will still enable RBMK design reactors to operate in the EU, in Lithuania. In addition, for the first time reactors in existing Member States will/may be closed for safety reasons effectively at the request of the EU. The enlarged EU will have 156 nuclear reactors in operation and will be the world's largest producer of nuclear electricity, generating around 32% of the Union's electricity. Accession countries largely mirror the EU's lack of new orders, as only Slovakia officially has any reactors under-construction, and so enlargement will not bring additional optimism for new construction. This lack of new orders is resulting in the ageing of the EU 25's reactor fleet, which has an average age of 22 years, up by 7 years in a decade. The current lack of new orders is predicted to result in a significant decline in the percentage contribution that nuclear power generation plays in the EU during the period 2015-2025. In part as a result of EU enlargement and in part due to this ageing trend, the European Commission has prepared two new Directives, one on nuclear safety and the other on radioactive waste management

  13. A visible QCD axion from an enlarged color group

    Science.gov (United States)

    Gherghetta, Tony; Nagata, Natsumi; Shifman, Mikhail

    2016-06-01

    We consider the possibility of an enlarged QCD color group, SU (3 +N') spontaneously broken to SU (3 )c×SU (N') with extra vectorlike quarks transforming in the fundamental representation. When the heavy quarks are integrated out below the PQ-breaking scale, they generate an axion coupling which simultaneously solves the strong C P problem for both gauge groups. However, the axion mass now receives a new nonperturbative contribution from the SU (N') confinement scale, which can be substantially larger than the QCD scale. This can increase the axion mass to be at or above the electroweak scale. This visible axion can then decay into gluons and photons giving rise to observable signals at run II of the LHC. In particular, if the mass is identified with the 750 GeV diphoton resonance, then the new confinement scale is ˜TeV and the PQ-breaking scale is ˜10 TeV . This predicts vectorlike quarks and a PQ scalar resonance in the multi-TeV range, with the possibility that dark matter is an SU (N') baryon.

  14. Interface fluctuations for deposition on enlarging flat substrates

    International Nuclear Information System (INIS)

    We investigate solid-on-solid models that belong to the Kardar–Parisi–Zhang (KPZ) universality class on substrates that expand laterally at a constant rate by duplication of columns. Despite the null global curvature, we show that all investigated models have asymptotic height distributions and spatial covariances in agreement with those expected for the KPZ subclass for curved surfaces. In 1 + 1 dimensions, the height distribution and covariance are given by the GUE Tracy–Widom distribution and the Airy2 process instead of the GOE and Airy1 foreseen for flat interfaces. These results imply that when the KPZ class splits into curved and flat subclasses, as conventionally considered, the expanding substrate may play a role equivalent to, or perhaps more important than, the global curvature. Moreover, the translational invariance of the interfaces evolving on growing domains allowed us to accurately determine, in 2 + 1 dimensions, the analog of the GUE Tracy–Widom distribution for height distribution and that of the Airy2 process for spatial covariance. Temporal covariance is also calculated and shown to be universal in each dimension and in each of the two subclasses. A logarithmic correction associated with the duplication of columns is observed and theoretically elucidated. Finally, crossover between regimes with fixed-size and enlarging substrates is also investigated. (paper)

  15. Interface fluctuations for deposition on enlarging flat substrates

    Science.gov (United States)

    Carrasco, I. S. S.; Takeuchi, K. A.; Ferreira, S. C.; Oliveira, T. J.

    2014-12-01

    We investigate solid-on-solid models that belong to the Kardar-Parisi-Zhang (KPZ) universality class on substrates that expand laterally at a constant rate by duplication of columns. Despite the null global curvature, we show that all investigated models have asymptotic height distributions and spatial covariances in agreement with those expected for the KPZ subclass for curved surfaces. In 1 + 1 dimensions, the height distribution and covariance are given by the GUE Tracy-Widom distribution and the Airy2 process instead of the GOE and Airy1 foreseen for flat interfaces. These results imply that when the KPZ class splits into curved and flat subclasses, as conventionally considered, the expanding substrate may play a role equivalent to, or perhaps more important than, the global curvature. Moreover, the translational invariance of the interfaces evolving on growing domains allowed us to accurately determine, in 2 + 1 dimensions, the analog of the GUE Tracy-Widom distribution for height distribution and that of the Airy2 process for spatial covariance. Temporal covariance is also calculated and shown to be universal in each dimension and in each of the two subclasses. A logarithmic correction associated with the duplication of columns is observed and theoretically elucidated. Finally, crossover between regimes with fixed-size and enlarging substrates is also investigated.

  16. Has EU Enlargement Been, and Will It Continue to Be, a Success? An Evaluation of EU Enlargement's Effects on Policies Pursued by Candidate Countries

    OpenAIRE

    Hlavac, Marek

    2010-01-01

    In this paper, I discuss whether enlargement has been a successful external policy of the European Union (EU). In particular, I evaluate the policy’s success based on its effects on the policies candidate countries have pursued. I argue that the prospect of entering the European Union has promoted beneficial democratic, economic and social reforms in candidate countries, and therefore can be judged to have been a success. I focus on two sets of enlargement rounds where the potential for t...

  17. Giant dacryocystomucopyocele in an adult: a review of lacrimal sac enlargements with clinical and histopathologic differential diagnoses.

    Science.gov (United States)

    Perry, Lynn J P; Jakobiec, Frederick A; Zakka, Fouad R; Rubin, Peter A D

    2012-09-01

    Dacryocystocele is an umbrella term that refers to any diffuse, centrifugal enlargement of the lacrimal sac that results from combined proximal and distal obstructions in the tear drainage system. In adults, the presence of mucus in the cyst's contents leads to the modified term of dacryocystomucocele. If infection supervenes, which almost always occurs in protracted cases and adds the clinical dimension of a dacryocystitis, then a dacryocystomucopyocele is created. Dacryocystocele and its congeners are much rarer in adults than in children. We describe a 95-year-old woman with an acquired, enormous dacryocystomucopyocele, larger than any previously reported, that developed over 25 years and produced globe displacement with an associated conspicuous enlargement of the nasolacrimal duct. The aspirated sac fluid was mucopurulent and harbored low-virulence bacterial organisms of the Prevotella and Petosteptococcus species. In infants, dacryocystoceles are transitory as the result of spontaneously reversible factors. In adults, secondary proximal irreversible fibrotic strictures or bony changes around the nasolacrimal duct typically arise from chronic inflammation or low grade infection. Other possible causations of duct obstruction, in addition to florid mucosal edema, include encroachment on the duct by enlarged contiguous ethmoid air cells; a sinus mucocele or sinusitis; idiopathic, post-traumatic or dysplastic bony remodeling of the wall of the duct; and a neoplasm-all of which require some form of surgical intervention, typically dacryocystorhinostomy. The differential diagnosis of medial canthal swellings centered on the lacrimal sac spans malformations, diverticula, dermoid/epidermoid cysts, sac inflammations/infections causing swelling without generalized sac enlargement, encephaloceles and primary epithelial tumors, as well as extrinsic tumors impinging on the sac. PMID:22784678

  18. Lower Temperature Cultures Enlarge the Effects of Vitreoscilla Hemoglobin Expression on Recombinant Pichia pastoris

    Directory of Open Access Journals (Sweden)

    Wei-Chang Fu

    2012-10-01

    Full Text Available An heterologous expression of Vitreoscilla hemoglobin (VHb for improving cell growth and recombinant protein production has been successfully demonstrated in various hosts, including Pichia pastoris. Lower temperature cultures can enhance target protein production in some studies of P. pastoris. In this study, the strategy of combining heterologous VHb expression and lower temperature cultures in P. pastoris showed that final cell density and viability of VHb+ strain at 23 °C were higher than that at 30 °C. In addition, the effects of VHb expression on recombinant β-galactosidase production and oxygen uptake rate were also higher at 23 °C than at 30 °C. Consequently, lower temperature cultures can enlarge VHb effectiveness on cell performance of P. pastoris. This is because VHb activity obtained at 23 °C cultures was twofold higher than that at 30 °C cultures, due to a different heme production. This strategy makes P. pastoris an excellent expression host particularly suitable for increasing the yields of the low-stability and aggregation-prone recombinant proteins.

  19. 46 CFR 502.105 - Waiver of rules governing enlargements of time and postponements of hearings.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Waiver of rules governing enlargements of time and postponements of hearings. 502.105 Section 502.105 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Time § 502.105 Waiver of rules governing enlargements of time and postponements of hearings....

  20. An enlarged intramuscular venous malformation in the femoral region successfully treated with complete resection

    OpenAIRE

    Takuo Murakami; Dai Ogata; Kyohei Miyano; Tetsuya Tsuchida

    2016-01-01

    Introduction: Intramuscular venous malformations have been previously described as intramuscular hemangiomas, and various therapies have been applied for their treatment. This condition is relatively rare, and therefore, physicians often struggle to determine the appropriate therapy. We presented a case of an enlarged intramuscular venous malformation relapsed after surgery successfully treated with complete resection. Presentation of case: We presented a case of an enlarged intramuscular ...

  1. Unilateral enlargement of the testis in childhood: does it need exploration?

    Science.gov (United States)

    MacMahon, R A; Cussen, L J

    1991-01-01

    Unilateral testicular enlargement in the pubertal boy is not an indication for exploration and biopsy, if the clinical features and investigations show no evidence of malignancy. In the prepubertal boy, unilateral testicular enlargement is not necessarily an indication for exploration if there are no clinical or investigational grounds for suspicion of neoplasia. Close follow-up is essential. PMID:2005529

  2. The fifth wave of the European Union enlargement: pro et contra

    OpenAIRE

    Batorshina, Irina A.

    2011-01-01

    This article analyses the principal complex of economic and political motivations of the states of Central and Eastern Europe and the EU members related to the EU enlargement towards the East. Special attention is paid to the discussion on the reasonableness of the EU enlargement and the positions of certain EU members.

  3. The Consequences of Eastern Enlargement of the European Union in Stages

    OpenAIRE

    SENIOR NELLO, Susan; Smith, Karen E.

    1997-01-01

    Contents I. Introduction II. The EU's Membership Conditions: Assessing Fulfillment A. The economic criteria for enlargement Progress in creating a functioning market economy i) Indicators of macroeconomic performance ii) Progress in microeconomic restructuring and privatisation Capacity to cope with competitive pressures and market forces in the Community Acceptance of the acquis communautaire concerning the Single Market B. The political criteria for enlargement ...

  4. Constraining Political Budget Cycles : Media Strength and Fiscal Institutions in the Enlarged EU

    NARCIS (Netherlands)

    Ademmer, Esther; Dreher, Ferdinand

    2016-01-01

    This article revisits institutional constraints to political budget cycles (PBCs) in the enlarged European Union (EU). Based on a panel of 25 Member States, we show that governments frequently fiscally stimulate the economy prior to elections. We argue that the occurrence of PBCs in the enlarged EU

  5. Histological and immunohistochemical features of gingival enlargement in a patient with AML

    NARCIS (Netherlands)

    N. Sonoi; Y. Soga; H. Maeda; K. Ichimura; T. Yoshino; K. Aoyama; N. Fujii; Y. Maeda; M. Tanimoto; R. Logan; J. Raber-Durlacher; S. Takashiba

    2012-01-01

    Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed bo

  6. The fifth wave of the European Union enlargement: pro et contra

    Directory of Open Access Journals (Sweden)

    Batorshina I. A.

    2011-01-01

    Full Text Available This article analyses the principal complex of economic and political motivations of the states of Central and Eastern Europe and the EU members related to the EU enlargement towards the East. Special attention is paid to the discussion on the reasonableness of the EU enlargement and the positions of certain EU members.

  7. Prevalence of enlarged mediastinal lymph nodes in heavy smokers - a comparative study

    Energy Technology Data Exchange (ETDEWEB)

    Kirchner, Johannes; Lorenz, Vivian-Wilma [Allgemeines Krankenhaus Hagen, Department of Diagnostic and Interventional Radiology, Hagen (Germany); Kirchner, Esther Maria [Staedtisches Klinikum Wedau, Clinic for Medicine, Duisburg (Germany); Goltz, Jan Peter; Kickuth, Ralph [University Hospital of Wuerzburg, Department of Radiology, Wuerzburg (Germany)

    2011-08-15

    To evaluate the frequency of enlarged hilar or mediastinal lymph nodes in heavy smokers (more than 10 pack years) compared with non- smokers. In a prospective study the CT findings of 88 consecutive patients (44 heavy smokers, 44 non- smokers) were analysed. Exclusion criteria were history of thoracic malignancy, sarcoidosis, occupational dust exposure or clinical evidence of pneumonia. Prevalence, size and site of enlarged lymph nodes were assessed by multidetector computed tomography (MDCT) and correlated with the cigarette consumption and the CT- findings of bronchitis and emphysema. Twenty-three of the 44 heavy smokers (52%) showed enlarged mediastinal lymph nodes. Non- smokers showed enlarged lymph nodes in 9% (4/44). The most common site of enlarged lymph nodes was the regional station 7 according to the ATS mapping (subcarinal). The difference between the frequency of enlarged lymph nodes in heavy smokers and non- smokers was significant (chi- square 19.3, p < 0.0001). Airway wall thickening and emphysema were often associated with an increased number of enlarged nodes. The present study demonstrates that enlarged mediastinal lymph nodes may occur in a rather high percentage of heavy smokers, especially in those with a MDCT finding of severe bronchitis. (orig.)

  8. Prevalence of enlarged mediastinal lymph nodes in heavy smokers - a comparative study

    International Nuclear Information System (INIS)

    To evaluate the frequency of enlarged hilar or mediastinal lymph nodes in heavy smokers (more than 10 pack years) compared with non- smokers. In a prospective study the CT findings of 88 consecutive patients (44 heavy smokers, 44 non- smokers) were analysed. Exclusion criteria were history of thoracic malignancy, sarcoidosis, occupational dust exposure or clinical evidence of pneumonia. Prevalence, size and site of enlarged lymph nodes were assessed by multidetector computed tomography (MDCT) and correlated with the cigarette consumption and the CT- findings of bronchitis and emphysema. Twenty-three of the 44 heavy smokers (52%) showed enlarged mediastinal lymph nodes. Non- smokers showed enlarged lymph nodes in 9% (4/44). The most common site of enlarged lymph nodes was the regional station 7 according to the ATS mapping (subcarinal). The difference between the frequency of enlarged lymph nodes in heavy smokers and non- smokers was significant (chi- square 19.3, p < 0.0001). Airway wall thickening and emphysema were often associated with an increased number of enlarged nodes. The present study demonstrates that enlarged mediastinal lymph nodes may occur in a rather high percentage of heavy smokers, especially in those with a MDCT finding of severe bronchitis. (orig.)

  9. Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition

    OpenAIRE

    Choi, Byung Yoon; Kim, Hyoung-Mi; Ito, Taku; Lee, Kyu-yup; Li, Xiangming; Monahan, Kelly; Wen, Yaqing; Wilson, Elizabeth; Kurima, Kiyoto; Saunders, Thomas L.; Petralia, Ronald S; Wangemann, Philine; Friedman, Thomas B.; Griffith, Andrew J.

    2011-01-01

    Mutations in human SLC26A4 are a common cause of hearing loss associated with enlarged vestibular aqueducts (EVA). SLC26A4 encodes pendrin, an anion-base exchanger expressed in inner ear epithelial cells that secretes HCO3– into endolymph. Studies of Slc26a4-null mice indicate that pendrin is essential for inner ear development, but have not revealed whether pendrin is specifically necessary for homeostasis. Slc26a4-null mice are profoundly deaf, with severe inner ear malformations and degene...

  10. The future of nuclear energy in the enlarged European Union

    International Nuclear Information System (INIS)

    The paper presents an analysis of the future of nuclear energy at the European level taking into account the main factors which influence its development among which the most important are: - enlargement of EU to 30 member states with different energy structure; - the increase of energy consumption; - the constant increasing of external dependence for energy which is estimated at 70% in the next 20-30 years; - liberalisation of the energy sources and supply sector; - environmental concerns, including climate change. In the Green Paper, nuclear is grouped together with coal, oil, gas and renewables as 'less than perfect' energy options and together with coal it is classed as an 'undesirable' and referred to as a 'source of energy in doubt ' which is ' tainted by the original sin of dual usage (civil and military) in the fuel cycle'. The final conclusion is 'the future of nuclear energy in Europe is uncertain'. It depends on several factors beyond energy demand; including: a solution to the problems of managing nuclear waste, the economic viability of the new generation of power stations, the safety of reactors in Eastern Europe, in particular applicant countries and policies to combat global warming. The 'essential questions' for nuclear is 'How can the community develop fusion technology and reactors for the future, reinforce nuclear safety and find a solution to the problem of nuclear waste?' There are a number of very important factors that will influence the future of nuclear energy inside the European Union. The first and foremost of these is continuing the safe operation of the existing nuclear facilities. The second is the demand for energy, in particular electricity. The third is the nuclear sector's ability to meet a share of this demand in a competitive way. If the demand materialises, there are likely to be reactors available that can further improve nuclear competitiveness while maintaining its recent excellent safety record. It will be the market that

  11. EFFECT OF ENLARGED FREE JET ON ENERGY CONVERSION IN PELTON TURBINE

    Institute of Scientific and Technical Information of China (English)

    LIU Jie; WEI Cai-xin; HAN Feng-qin

    2006-01-01

    In Pelton turbines, when the water jet emerges in the air, its velocity decreases downstream and its diameter increases to meet the continuity. In this paper, a physical parameter, the enlarging rate of jet diameter kDj was introduced and measured experimentally. The measurement of enlarging rate was carried out in three model turbines with different distributing Y-branch and nozzle configurations under various operating conditions. The effect of jet enlarging rate on the unsteady water sheet flow in the rotating buckets has not been investigated so far. This paper also presents the comparative numerical analysis of the flow in buckets at different enlarging rates of jet. It is shown that the effect of jet enlargement is so large that the flow pattern in the bucket is drastically changed by the latter half of the frames. The jet with large enlarging rate also introduces worse energy behavior to the hydraulic performance of the Pelton turbine. Besides, the phenomenon of jet interference was also discussed by using the results of numerical simulation for one jet. It indicates that the jet with large enlarging rate takes more risk that jet interference may damage the performance of multi-nozzle Pelton turbine.

  12. Enlarged hilar and mediastinal lymph nodes in chronic obstructive pulmonary disease

    International Nuclear Information System (INIS)

    Full text: Methods: In a retrospective study, 89 patients with proven COPD were analysed. Exclusion criteria were history of malignant disease or clinical evidence of pneumonia. Prevalence, size, and localisation of enlarged lymph nodes were assessed by multi-slice computed tomography (MSCT) and correlated with the clinical stages following the GOLD classification as well as the MSCT findings of bronchitis and emphysema. Results: 44/89 (49%) of our patients showed enlarged lymph nodes. Lymph node enlargement was more often seen in the mediastinum (48%) than the hilar region (20%). The most common localisation of enlarged mediastinal lymph nodes was the regional station 7 following the ATS mapping (infracarinal). Patients with a stage I following the GOLD classification showed enlarged lymph nodes in 49% (18/37), stage II in 46% (12/26), stage III in 58% (7/12) and stage IV in 50% (7/14). These findings did not differ significantly (P> 0.05). Severe airway wall thickening (42/89) was significantly more often associated with an increase of nodal enlargement (64%) (P < 0.05). Conclusion: The present study demonstrates that enlarged hilar and mediastinal lymph nodes may occur in a rather high percentage of patients suffering from COPD, especially in those with the MSCT finding of severe bronchitis.

  13. Eponyms related to genetic disorders associated with gingival enlargement; part II

    Directory of Open Access Journals (Sweden)

    Nora Mohammed Al-Aboud

    2015-01-01

    Full Text Available There are genetic disorders associated with gingival enlargement. In our part I, we reviewed the eponyms linked to Hereditary Gingival Fibromatosis (HGF [1]. Historical Article How to cite this article: Al Aboud A, Al-Aboud NM, Barnawi H, Al Hakami A. Eponyms related to genetic disorders associated with gingival enlargement: Part II. Our Dermatol Online. 2015;6(1:114-117. Submission: 27.05.2013; Acceptance: 21.09.2014 DOI: 10.7241/ourd.20151.32 In this part II of this review, we are going to shed some light on eponyms linked to groups of genetic disorders which may feature gingival enlargement.

  14. Roentgenography with direct enlargement of image and roentgenopneumopolygraphy as additional methods for early diagnosis of pneumoconiosis

    International Nuclear Information System (INIS)

    The efficacy of roentgenography with direct enlargement of image and roentgenopneumopolygraphy (RPPG) combined with other X-ray and clinical methods was studied in 120 patients suffering from pneumoconioses. The comparison of skialogy results and comparative evaluation of morphological changes showed that an intensified and deformed pulmonary pattern, initial changes of small units of the division of vessels, bronchi and the presence of nodules were determined more clearly on enlarged radiograms. RPPG is effective for a study of functional shifts of the bronchopulmonary system in pneumoconioses. Roentgenography with direct enlargement of image and RPPG can be used for early diagnosis of pneumoconioses and the determination of efficacy of their treatment

  15. Successful management of phenytoin and phenobarbitone induced gingival enlargement: A multimodal approach

    Science.gov (United States)

    Priyadharshini, V.; Belure, Vinita V.; Triveni, M. G.; Tarun Kumar, A. B.; Mehta, D. S.

    2014-01-01

    Medication-related gingival enlargement is a common reactionary phenomenon that occurs with the use of several types of therapeutic agents, including antiepileptic drugs (AEDs). This disorder has been documented since 1939, shortly after the introduction of phenytoin. In the present case, a concise review of literature concerning the etiopathogenesis and management of AEDs (phenobarbitone and phenytoin) induced gingival enlargement has been described. It is vital that not only the periodontist, but also dental surgeons and medical practitioners should become aware of the potential etiologic agents, characteristic features, and the differential diagnosis of drug induced gingival enlargement in order to be able to prevent, diagnose and successfully manage the condition. PMID:24963262

  16. Successful management of phenytoin and phenobarbitone induced gingival enlargement: A multimodal approach

    Directory of Open Access Journals (Sweden)

    V Priyadharshini

    2014-01-01

    Full Text Available Medication-related gingival enlargement is a common reactionary phenomenon that occurs with the use of several types of therapeutic agents, including antiepileptic drugs (AEDs. This disorder has been documented since 1939, shortly after the introduction of phenytoin. In the present case, a concise review of literature concerning the etiopathogenesis and management of AEDs (phenobarbitone and phenytoin induced gingival enlargement has been described. It is vital that not only the periodontist, but also dental surgeons and medical practitioners should become aware of the potential etiologic agents, characteristic features, and the differential diagnosis of drug induced gingival enlargement in order to be able to prevent, diagnose and successfully manage the condition.

  17. Gingival Enlargement In Epileptic Patients On Phenytoin Therapy-An Overview Of Possible Etiologies And Studies

    Directory of Open Access Journals (Sweden)

    Abhishek Singh Nayyar

    2013-01-01

    Full Text Available Epilepsy is a common neurological disorder with recurrent seizures due to a chronic underlying process. Despite tremendous advances in the field of understanding regarding the etio-pathogenesis of epilepsy, phenytoin still remains the drug of choice in its management. Chronic administration of phenytoin has been associated to have a number of adverse effects. Gingival enlargement is one such most often reported adverse drug sequela of long term phenytoin usage with exclusion of local factors contributing towards gingival enlargement. This review gives an overview regarding the association of phenytoin and gingival enlargement seen in epileptic patients being treated with phenytoin.

  18. Cooperative diplomacy: Citizens, sovereignty, and the logic of democratic enlargement

    Science.gov (United States)

    Ndungu, Anthony Mark

    2000-12-01

    that intergovernmental agreement on compliance questions is most likely to occur when decision-making and policy-implementing processes are decentralized, and when governments establish and support decentralized intra- and trans-governmental institutions that enable private domestic groups of individuals to participate in international governance through two mechanisms. First, those decentralized institutions facilitate the formation of transnational coalitions of politically autonomous private domestic groups that can serve as a ``horizontal transmission belt'' for ideas and practices among private and public proponents of the major opposing domestic positions, thereby generating public transnational deliberation on compliance, monitoring and distributive questions. Second, politically autonomous private domestic groups can, by engaging in performance-based partnerships with senior government officials, also serve as a ``vertical transmission belt'' between domestic and intergovernmental regimes and vice versa, thereby encouraging their respective governments to adapt the social practices in issue-specific domestic regimes to international structural forces. These findings have significant ramifications for the concept of democratic enlargement, the institutionalization of competitive pluralism in non- liberal states. The robustness, across changes in administrations both at home and abroad, of the norms codified in international agreements may hinge on institutionalizing the participation of politically autonomous private domestic groups in decentralized intra- and trans-governmental decision-making and policy- implementing processes.

  19. Chest CT findings in EBUS-TBNA-proven anthracosis in enlarged mediastinal lymph nodes

    Energy Technology Data Exchange (ETDEWEB)

    Kirchner, J. [Allgemeines Krankenhaus Hagen (Germany). Dept. of Interventional and Diagnostic Radiology; Mueller, P. [Allgemeines Krankenhaus Hagen (Germany). Dept. of Medicine; Broll, M.; Kirchner, E.M. [Sana Klinikum Duisburg (Germany). Dept. of Medicine; Pomjanski, N.; Biesterfeld, S. [University Hospital Duesseldorf (Germany). Dept. of Pathology; Liermann, D. [Marien Hospital, Herne (Germany). Dept. of Diagnostic and Interventional Radiology and Nuclear Medicine; Kickuth, R. [University Hospital Wuerzburg (Germany). Dept. of Radiology

    2014-12-15

    We demonstrate the multislice computed tomography (MSCT) findings of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)-proven hilar and mediastinal lymph node enlargement with signs of anthracosis. 53 enlarged lymph nodes in 39 patients (28 male, 11 female) with EBUS-TBNA-confirmed anthracosis were analyzed retrospectively. The mean short axis diameter of the enlarged lymph nodes with signs of anthracosis was 13.7 mm. Lymph nodes most often showed an oval shape (84%) and were well defined in 66% of cases. Lymph node confluence was observed in 32% of cases. Calcifications were documented in 24.5% of cases. Contrast enhancement and fatty involution were seen seldom (3.8%). Lymph node necrosis was not seen. Lymph node anthracosis may be found most often in enlarged, well defined lymph nodes with an oval shape, frequently associated with confluence and calcifications.

  20. Chest CT findings in EBUS-TBNA-proven anthracosis in enlarged mediastinal lymph nodes

    International Nuclear Information System (INIS)

    We demonstrate the multislice computed tomography (MSCT) findings of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)-proven hilar and mediastinal lymph node enlargement with signs of anthracosis. 53 enlarged lymph nodes in 39 patients (28 male, 11 female) with EBUS-TBNA-confirmed anthracosis were analyzed retrospectively. The mean short axis diameter of the enlarged lymph nodes with signs of anthracosis was 13.7 mm. Lymph nodes most often showed an oval shape (84%) and were well defined in 66% of cases. Lymph node confluence was observed in 32% of cases. Calcifications were documented in 24.5% of cases. Contrast enhancement and fatty involution were seen seldom (3.8%). Lymph node necrosis was not seen. Lymph node anthracosis may be found most often in enlarged, well defined lymph nodes with an oval shape, frequently associated with confluence and calcifications.

  1. Management of amlodipine-induced gingival enlargement: Series of three cases

    Directory of Open Access Journals (Sweden)

    Srivastava Amit

    2010-01-01

    Full Text Available Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia. This case series presents diagnosis and management of amlodipine-induced gingival hyperplasia. Amlodipine-induced gingival enlargement was diagnosed and managed by thorough scaling and root planning. Drug substitution and surgical intervention was performed in first two cases. The pathogenesis of gingival enlargement is uncertain and the treatment is still largely limited to the maintenance of an improved level of oral hygiene and surgical removal of the overgrown tissue. Several factors may influence the relationship between the drugs and gingival tissues as discussed by Seymour et al. Meticulous oral hygiene maintenance, switchover to alternative drug, professional scaling and root planning and surgical excision of enlarged gingival tissue may help overcome the effect of these drugs.

  2. Cytological evaluation of enlarged lymph nodes in metastatic disease: A hospital-based assessment

    Directory of Open Access Journals (Sweden)

    Ghazala Mehdi

    2015-01-01

    Full Text Available Background: Lymphadenopathy is a heterogeneous entity with many underlying causes, ranging from self-limiting benign disease to severe neoplastic proliferations. Fine-needle aspiration is a cost-effective and reliable tool for initial investigation of enlarged lymph nodes. Materials and Methods: A study was conducted on 326 patients with metastatic disease in order to evaluate the efficacy of cytology in diagnosing malignancies metastatizing to the lymph node and predicting their primary origin as well as to find the relative frequency of different malignancies. The findings were also correlated with histopathology. Results: Cervical lymph nodes were the most frequently involved group, followed by axillary, supraclavicular, and inguinal lymph nodes. Squamous cell carcinoma (SCC and adenocarcinoma were the most common cytological diagnosis. Among the cases with known primary tumors, head and neck was the most common site followed by breast carcinoma. Most common lymph node group to be aspirated in cases with unknown primary was cervical lymph node, and SCC was most frequently diagnosed cases. Sensitivity and positive predictive value of cytological diagnosis were calculated to be 100% and 93.1%, respectively. Conclusion: Fine-needle aspiration cytology has a very high sensitivity and positive predictive value and hence, a presumptive diagnosis can be made along with the detection of the primary site in case of metastatic disease.

  3. Hydrodynamic performance of a three-phase airlift bioreactor with an enlarged degassing zone

    OpenAIRE

    Vicente, A.A.; Teixeira, J.A.

    1995-01-01

    The hydrodynamics of biotechnological processes is complex. So far, few studies were made with bioreactors of the airlift type with an enlarged degassing zone. In this work, the influence of solids loading, solids specific gravity and draught tube dimensions on mixing and circulation times and critical air flow rate for an internal loop airlift bioreactor with an enlarged sedimentation/degassing zone is studied. The results indicate that the critical air flow rate as well as the mixing ...

  4. Management of amlodipine-induced gingival enlargement: Series of three cases

    OpenAIRE

    Srivastava Amit; Kundu Debabrata; Bandyopadhyay Prasanta; Pal Asit

    2010-01-01

    Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia. This case series presents diagnosis and management of amlodipine-induced gingival hyperplasia. Amlodipine-induced gingival enlargement was diagnosed and managed by thorough scaling and root planning. Drug substitution and surgical intervention was performed in first two cases. The pathogenesis o...

  5. Enlarging the European Union: The short-term success of incrementalism and de-politicisation

    OpenAIRE

    Falkner, Gerda; Nentwich, Michael

    2000-01-01

    This paper analyses the most important issues of the EU enlargement process. We first discuss an empirical paradox involved in enlargement: the obvious development of the original European Communities into a Union with important supranational features and ever more policy clout has by no means discouraged aspirant member states. Why is it that more and more states are willing to give up much of their otherwise cherished national sovereignty by joining this Union, knowing that even more sovere...

  6. INSTITUTIONAL EVOLUTION OF EUROPEAN UNION TOWARD THE ENLARGEMENT. REFORMING ASPECTS OF THE INSTITUTIONAL SYSTEM

    OpenAIRE

    TESCAŞIU BIANCA

    2013-01-01

    One of the major challenge of the European Community is to adapt an initial institutional system to a new situation. European Union’s enlargement created a new context in its architecture and, also, in solving new and specific problems requested by this enlargement. The institutions became over-numbered and not enough optimal in their decisions. Also, different new members of the Community had different visions about the future of European Union, about the institutional system, about the majo...

  7. Costs and Benefits of the EU Enlargement: The Impact on the EU and SEE Countries

    OpenAIRE

    Nuroğlu, Elif; Kurtagic, Haris

    2012-01-01

    The south-eastern enlargement of the European Union will be the sixth enlargement since the establishment of the European Community in 1957. This research uses the gravity model to analyze the factors that have an influence on trade flows between the EU and South-east European Countries. The Gravity model explains patterns of trade with GDP, geographical distance and several dummy variables. Using the data from 2010, the gravity model analyzes trade flows between 23 countries from both the EU...

  8. Broadening and deepening or broadening versus deepening: The question of enlargement and Europe's 'hesitant Europeans'

    OpenAIRE

    Karp, Jeffrey A.; Bowler, Shaun

    2006-01-01

    The European Union sees the inclusion of many Eastern European states -enlargement- as a natural progression in the process of building an 'ever closer union'. For the European Commission in particular, the process of enlargement (broadening) is part of the process of integration and acts as a complement to the development of a stronger role for the European Union and its institutions or deepening of integration. Yet as the first Irish referendum on the Nice Treaty showed, not all of European...

  9. The eastward enlargement of the eurozone: social and policy aspects in Portugal, Spain and Italy

    OpenAIRE

    Galego, Aurora; Caétano, José; Costa, Sofia; Liiv, Reilika

    2003-01-01

    This report explores some features of the social dimension of enlargement regarding the Southern EU-Member countries, namely Portugal, Spain and Italy. Economic theory suggests that integration may affect wages, employment and income distribution through changes on trade, FDI and migration flows. By removing all barriers to the free movement of goods and services, capital and labour, Eastward Enlargement will affect the location of economic activities, innovation, and technology. Subsequently...

  10. Acceleration-Enlarged Symmetries in Nonrelativistic Space-Time with a Cosmological Constant

    OpenAIRE

    Lukierski, J.; Stichel, P. C.; Zakrzewski, W. J.

    2007-01-01

    By considering the nonrelativistic limit of de-Sitter geometry one obtains the nonrelativistic space-time with a cosmological constant and Newton-Hooke (NH) symmetries. We show that the NH symmetry algebra can be enlarged by the addition of the constant acceleration generators and endowed with central extensions (one in any dimension (D) and three in D=(2+1)). We present a classical Lagrangian and Hamiltonian framework for constructing models quasi-invariant under enlarged NH symmetries which...

  11. Lymph node enlargement in pulmonary arterial hypertension due to chronic thromboembolism

    International Nuclear Information System (INIS)

    The aim of this study was to determine the prevalence and location of enlarged mediastinal and hilar lymph nodes in patients with pulmonary arterial hypertension (PAH) due to chronic pulmonary thromboembolism (CPTE) and to identify possible causes. Thoracic CT images of 85 patients(43 men and 42 women, aged 18-80 years) with PAH in whom CPTE was confirmed at surgery (n = 75) or angiography and angioscopy (n = 10) were evaluated by two thoracic radiologists to determine the presence, size and location of lymph nodes more than 1 cm in the short axis. The presence of pleural and pericardial effusions and parenchymal abnormalities were also noted. Enlarged lymph nodes were identified in 38 patients (44.7%), including 11 with possible causes of lymphadenopathy other than CPTE. In the 27 patients with CPTE alone, 67 enlarged lymph nodes were detected (average 2.5 per patient). Nine patients had three or more enlarged lymph nodes. The most common sites of lymph node enlargement were American Thoracic Society locations 7 (n = 13), 6 (n = 10), 11L (n = 9), 10R (n = 7) and 4R (n = 7). Pleural and pericardial effusions were more common in patients with CPTE who also had lymphadenopathy than in the group with no lymphadenopathy (P < 0.05). Lymph node enlargement is common in patients with PAH caused by CPTE. The frequent association of lymphadenopathy with pleural and pericardial effusions suggest a possible pathophysiological mechanism of increased lymphatic flow caused by right heart failure.

  12. Enlarging Pancreatic Schwannoma – A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Narjust Duma

    2015-07-01

    Full Text Available Context Schwannomas are rare neoplasms that typically occur in the peripheral nerve of the extremities. Visceral localization of these tumors is particularly rare. We present a unique case of a pancreatic schwannoma presenting as long-lasting dyspepsia and intermittent epigastric pain. Case report Seventy-two-year-old female presented with dyspepsia for 2 years and an incidental mass in the head of the pancreas on abdominal CT scan. Patient had multiple negative endoscopic ultrasound guided biopsies and a non-diagnostic open core biopsy. She was followed up for 3 years with serial imaging until an abdominal CT scan showed an increase in size of the pancreatic mass from 1.9x2.2 cm to 3.1x2.7 cm. Physical examination was unremarkable. Laboratory tests including tumor markers were normal. Given the enlarging size of the mass and its impingement on the portal vein, the consensus was to proceed with surgery. Patient underwent a nonpylorus preserving pancreaticoduodenectomy. Histology revealed a 3.5 cm mass showing a spindle cell neoplasm with mild atypia. The lesion was well defined and nerve tissue was noted at the periphery. On immuno stains, the spindle cells were positive for S-100 protein and negative for pancytokeratin, CD-34, CD-117, smooth muscle actin and Melan A, consistent with the diagnosis of a prancreatic schwannoma. Conclusions Pancreatic schwannomas arise from branches of the vagus nerve which courses through the pancreas. Pre-operative diagnosis of pancreatic schwannomas is difficult even with multiple imaging modalities. The final diagnosis of these tumors is often made only after operative excision and histological studies.

  13. Endolymphatic Sac Enlargement in a Girl with a Novel Mutation for Distal Renal Tubular Acidosis and Severe Deafness

    Directory of Open Access Journals (Sweden)

    Rink Nikki

    2012-01-01

    Full Text Available Hereditary distal renal tubular acidosis (dRTA is caused by mutations of genes encoding subunits of the H+-ATPase (ATP6V0A4 and ATP6V1B1 expressed in α-intercalated cells of the distal renal tubule and in the cochlea. We report on a 2-year-old girl with distal RTA and profound speech delay which was initially misdiagnosed as autism. Genetic analysis showed compound heterozygous mutations with one known and one novel mutation of the ATP6V1B1 gene; cerebral magnetic resonance imaging (MRI revealed bilateral enlargement of the endolymphatic sacs of the inner ear. With improved cooperation, audiometric testing showed that hearing loss was most profound on the right, where endolymphatic sac enlargement was greatest, demonstrating a clear link between the degree of deafness and the degree of inner ear abnormality. This case indicates the value of MRI for diagnosis of inner ear involvement in very young children with distal RTA. Although citrate therapy quickly corrects the acidosis and restores growth, early diagnosis of deafness is crucial so that hearing aids can be used to assist acquisition of speech and to provide enough auditory nerve stimulation to assure the affected infants remain candidates for cochlear implantation.

  14. Endolymphatic sac enlargement in a girl with a novel mutation for distal renal tubular acidosis and severe deafness.

    Science.gov (United States)

    Nikki, Rink; Martin, Bitzan; Gus, O'Gorman; Mato, Nagel; Elena, Torban; Paul, Goodyer

    2012-01-01

    Hereditary distal renal tubular acidosis (dRTA) is caused by mutations of genes encoding subunits of the H(+)-ATPase (ATP6V0A4 and ATP6V1B1) expressed in α-intercalated cells of the distal renal tubule and in the cochlea. We report on a 2-year-old girl with distal RTA and profound speech delay which was initially misdiagnosed as autism. Genetic analysis showed compound heterozygous mutations with one known and one novel mutation of the ATP6V1B1 gene; cerebral magnetic resonance imaging (MRI) revealed bilateral enlargement of the endolymphatic sacs of the inner ear. With improved cooperation, audiometric testing showed that hearing loss was most profound on the right, where endolymphatic sac enlargement was greatest, demonstrating a clear link between the degree of deafness and the degree of inner ear abnormality. This case indicates the value of MRI for diagnosis of inner ear involvement in very young children with distal RTA. Although citrate therapy quickly corrects the acidosis and restores growth, early diagnosis of deafness is crucial so that hearing aids can be used to assist acquisition of speech and to provide enough auditory nerve stimulation to assure the affected infants remain candidates for cochlear implantation. PMID:22966473

  15. Rapidly enlarging renal tumor during pregnancy: diagnostic and management dilemma

    Directory of Open Access Journals (Sweden)

    Kor Wei Tiang

    2014-04-01

    Full Text Available Urological tumors diagnosed during pregnancy are rare. However, the incidence seems to be increasing largely due to advancements in modern imaging techniques and improved antenatal care. The diagnosis and management of renal tumors during pregnancy poses a dilemma to clinicians. This case report highlights the challenges in managing a large chromophobe renal cell carcinoma in a young primigravida patient. Proper antenatal assessment, a multidisciplinary team approach and appropriate discussion with patient are important determinants to achieve the best clinical outcomes for both the mother and the baby. 

  16. Rapid liver enlargement and hepatic failure secondary to radiographic occult tumor invasion: two case reports and review of the literature

    Directory of Open Access Journals (Sweden)

    Simone Christine

    2012-11-01

    Full Text Available Abstract Introduction Unfamiliarity with certain clinical presentations, as illustrated in these cases, can lead to delayed diagnoses that in turn cause increased morbidity, prolonged hospitalization, and the need for autopsy. Case presentation In Case 1, a 63-year-old Caucasian woman presented with hepatic enlargement and insufficiency which progressed and resulted in her death over a period of less than 2 weeks. The patient underwent a detailed workup included magnetic resonance imaging and computed tomography scan of her liver, which did not reveal the source of her liver enlargement. Due to her progressive liver enlargement and insufficiency, she developed a life-threatening esophageal variceal bleeding during her hospital stay which further delayed the attainment of her diagnosis. She finally underwent a videoscopic laparotomy and liver biopsy which revealed complete replacement and filling in of the liver sinuous with Indian filing lobular breast cancer. The patient died shortly after her diagnosis and before she could be discharged. In Case 2, a 68-year-old Caucasian woman with non-small-cell lung cancer was admitted to our Oncology in-patient service with a presentation of rapid hepatic insufficiency and severe liver enlargement. Like the patient in Case 1, during her hospitalization, this patient underwent a thorough radiographic evaluation, including computed tomography and magnetic resonance imaging, to identify the source of her symptoms. Radiographic imaging showed only hepatomegaly and no discrete focal lesions. As the multiple imaging studies over a period of a week did not reveal a clear cause for her symptoms, she finally underwent an interventional radiology core biopsy which showed complete replacement of her liver with non-small-cell lung cancer. Her condition rapidly progressed due to continued liver enlargement and she died due to frank liver failure before her diagnosis was affirmed and she could be discharged. Conclusion

  17. Portugal and the EU’s Eastern Enlargement: A logic of identity endorsement

    Directory of Open Access Journals (Sweden)

    Arne Niemann

    2012-07-01

    Full Text Available This paper addresses the puzzle of why Portugal has consistently supported the EU’s fifth enlargement. We argue that standard explanations, based on welfare maximisation, geopolitics, or rhetorical action, cannot persuasively account for this policy choice. Instead, we advance an alternative explanation – subsequently referred to as ‘identity endorsement –that is based on a logic of appropriateness where behaviour is shaped by aspects of similarity and congruence, and where the development of Portuguese identity has constituted what has been perceived as appropriate in the context of Eastern enlargement. We argue that EC/EU membership has provided Portuguese political elites with a renewed collective identity, in which a choice for membership has been equated with a choice for democracy, stability and openness. Portuguese support for Eastern enlargement has consistently been based on these concepts that originated from Portugal’s own period of accession negotiations. By fully supporting Eastern enlargement, Portugal could act together with the ‘European core’, and Portugal itself would become more ‘core’, i.e. more European. For Portuguese political elites, supporting Eastern enlargement thus constituted an act of ‘identity endorsement’, i.e. the confirmation, (re-production and reinforcement of existing identity constructions. We tentatively suggest that the notion of identity endorsement may also shed light on other empirical puzzles related to European integration.

  18. Pyrrolidine dithiocarbamate reduces the progression of total kidney volume and cyst enlargement in experimental polycystic kidney disease.

    Science.gov (United States)

    Ta, Michelle H T; Rao, Padmashree; Korgaonkar, Mayuresh; Foster, Sheryl F; Peduto, Anthony; Harris, David C H; Rangan, Gopala K

    2014-12-01

    Heterocyclic dithiocarbamates have anti-inflammatory and anti-proliferative effects in rodent models of chronic kidney disease. In this study, we tested the hypothesis that pyrrolidine dithiocarbamate (PDTC) reduces the progression of polycystic kidney disease (PKD). Male Lewis polycystic kidney (LPK) rats (an ortholog of Nek8/NPHP9) received intraperitoneal injections of either saline vehicle or PDTC (40 mg/kg once or twice daily) from postnatal weeks 4 until 11. By serial magnetic resonance imaging at weeks 5 and 10, the relative within-rat increase in total kidney volume and cyst volume were 1.3-fold (P = 0.01) and 1.4-fold (P < 0.01) greater, respectively, in LPK + Vehicle compared to the LPK + PDTC(40 mg/kg twice daily) group. At week 11 in LPK rats, PDTC attenuated the increase in kidney weight to body weight ratio by 25% (P < 0.01) and proteinuria by 66% (P < 0.05 vs. LPK + Vehicle) but did not improve renal dysfunction. By quantitative whole-slide image analysis, PDTC did not alter interstitial CD68+ cell accumulation, interstitial fibrosis, or renal cell proliferation in LPK rats at week 11. The phosphorylated form of the nuclear factor (NF)-κB subunit, p105, was increased in cystic epithelial cells of LPK rats, but was not altered by PDTC. Moreover, PDTC did not significantly alter nuclear expression of the p50 subunit or NF-κB (p65)-DNA binding. Kidney enlargement in LPK rats was resistant to chronic treatment with a proteasome inhibitor, bortezomib. In conclusion, PDTC reduced renal cystic enlargement and proteinuria but lacked anti-inflammatory effects in LPK rats. PMID:25501440

  19. Pneumocystis Pneumonia Presenting as an Enlarging Solitary Pulmonary Nodule

    Directory of Open Access Journals (Sweden)

    Krunal Bharat Patel

    2016-01-01

    Full Text Available Pneumocystis pneumonia is a life threatening infection that usually presents with diffuse bilateral ground-glass infiltrates in immunocompromised patients. We report a case of a single nodular granulomatous Pneumocystis pneumonia in a male with diffuse large B-cell lymphoma after R-CHOP therapy. He presented with symptoms of productive cough, dyspnea, and right-sided pleuritic chest pain that failed to resolve despite treatment with multiple antibiotics. Chest X-ray revealed right lower lobe atelectasis and CT of chest showed development of 2 cm nodular opacity with ground-glass opacities. Patient underwent bronchoscopy and biopsy that revealed granulomatous inflammation in a background of organizing pneumonia pattern with negative cultures. Respiratory symptoms resolved but the solitary nodular opacity increased in size prompting a surgical wedge resection which revealed granulomatous Pneumocystis pneumonia infection. This case is the third documented report of Pneumocystis pneumonia infection within a solitary pulmonary nodule in an individual with hematologic neoplasm. Although Pneumocystis pneumonia most commonly occurs in patients with HIV/acquired immunodeficiency syndrome and with diffuse infiltrates, the diagnosis should not be overlooked when only a solitary nodule is present.

  20. The EU and ‘Enlargement Fatigue’: Why Has the European Union Not Been Able to Counter ‘Enlargement Fatigue’?

    Directory of Open Access Journals (Sweden)

    Anna Szolucha

    2010-05-01

    Full Text Available This article provides an up-to-date overview of the problems connected with European integration. It focuses on the phenomenon of ‘enlargement fatigue’ and examines its meaning as utilised by the media, EU officials and academics. The article argues that ‘enlargement fatigue’ is not a new concept since the EU has witnessed many 'symptoms' of fatigue at multiple times in its history. The two main arguments that are often presented in order to explain why the EU has not been able to counter ‘enlargement fatigue’, namely the insufficiently tight conditionality applied to prospective members and the EU's crisis of confidence and accountability after the failed attempt to introduce the Constitutional Treaty and prolonged Lisbon Treaty ratification process, are insufficient to explain why fatigue has been so persistent a phenomenon. This article argues that the EU's failure to develop a new vision of the organisation and adjust its structural design accordingly is a reason why the Union has not dealt successfully with fatigue. Such a vision would encompass notions of “variable geometry”, “avant-garde groups” and make European borders flexible and fuzzy.

  1. [Somatotopic Representation of the Anterior Horn within Cervical Enlargement: Reappraisal of Known Doctrine Based on Clinicopathological Findings Seen in Hirayama Disease].

    Science.gov (United States)

    Hirayama, Keizo

    2016-05-01

    Clinical features (weakness and amyotrophy of intrinsic hand muscles and obliquely distributed amyotrophy of forearm muscles, figure 1), needle electromyographic findings (distribution of neurogenic activities, figure 2), and pathological findings (ischemic necroses of the anterior horns between C6 and T1, figure 3) of Hirayama disease suggest that understanding of somatotopic representation of the anterior horn innervating arm muscles in the cervical enlargement of spinal cord differs from the known doctrine. Anterior horn cells of the intrinsic hand muscles are located between C7 and T1, those of forearm muscles and triceps brachii muscle as elbow extensor are, contrary to the known doctrine, located in C5 and C6, and those of elbow flexors such as biceps brachii and brachioradialis are located in C4 and above (figure 5). Development of dexterity in human hand may reflect development of cervical enlargement in accord with larger areas representing the hand and fingers on cerebral motor cortex. PMID:27156506

  2. Etiologic significance of enlargement of the left atrial appendage in adults

    Energy Technology Data Exchange (ETDEWEB)

    Green, C.E.; Kelley, M.J.; Higgins, C.B.

    1982-01-01

    Fifty-one patients were divided into two groups: 20 patients with proven rheumatic mitral valve disease (RMVD) and 31 patients with left atrial enlargement (LAE) of a nonrheumatic etiology. The latter group included patients with ischemic papillary muscle dysfunction, mitral valve prolapse, and congestive cardiomyopathy. Radiographic studies showed that enlargement of the left atrial appendage (LAAE) was present in 18 of 20 rheumatics but in only one of 31 nonrheumatics. There was no direct relationship between enlargement of the LAA and radiographic or echocardiographic left atrial size, degree of pulmonary venous hypertension (PVH), or presence of atrial fibrillation. It is postulated that rheumatic influammation of the LAA allows it to dilate out of proportion to the body of the left atrium. In the adult patient with radiographic findings of PVH, LAAE is a valuable and specific radiographic sign of rheumatic mitral valve disease.

  3. A Rare Case Report of Amlodipine-Induced Gingival Enlargement and Review of Its Pathogenesis

    Directory of Open Access Journals (Sweden)

    Sanjeev Joshi

    2013-01-01

    Full Text Available Gingival enlargement is a common clinical feature of gingival and periodontal diseases. It is an unwanted side effect of certain systemic drugs given for nondental treatment. It is being reported with three main groups of drugs like calcium channel blockers (CCBs, immunosuppressants, and anticonvulsants. Among calcium channel blockers, nifedipine causes gingival hyperplasia in about 10% of patients, whereas the incidence of amlodipine-, a third generation calcium channel blocker, induced gingival hyperplasia is very limited. There are very few reports of amlodipine-induced gingival enlargement at a dose of 5 mg. We report a case of amlodipine-induced gingival enlargement in a 45-year-old hypertensive patient taking amlodipine at a dose of 5 mg.

  4. Transcatheter Arterial Embolization Using Ethanol in a Dialysis Patient for Contracting Enlarged Polycystic Kidneys

    Energy Technology Data Exchange (ETDEWEB)

    Rim, Hark; Jung, Gyoo Sik; Jung, Yeon Soon [Kosin University College of Medicine, Gospel Hospital, Busan (Korea, Republic of)

    2010-10-15

    The mass effect of nephromegaly in patients with autosomal dominant polycystic kidney disease may cause pain and symptoms by compressing the alimentary tract, lungs, and heart. Conventional therapies exist to contract enlarged polycystic kidneys including surgical and interventional procedures. A surgical nephrectomy is often difficult to perform in dialysis patients due to the associated risks related to surgery. In contrast, renal transcatheter arterial embolization (TAE) with metallic coils, which is a less invasive interventional procedure, can also be utilized to contract enlarged kidneys in dialysis patients as an effective treatment. However, metallic coils present the possibility of recanalization and cost issues. Thus, we used ethanol instead of coils in renal TAE to resolve these issues. We report a dialysis patient with enlarged polycystic kidneys and poor oral intake due to abdominal distention that was successfully treated by TAE with absolute ethanol

  5. Transcatheter Arterial Embolization Using Ethanol in a Dialysis Patient for Contracting Enlarged Polycystic Kidneys

    International Nuclear Information System (INIS)

    The mass effect of nephromegaly in patients with autosomal dominant polycystic kidney disease may cause pain and symptoms by compressing the alimentary tract, lungs, and heart. Conventional therapies exist to contract enlarged polycystic kidneys including surgical and interventional procedures. A surgical nephrectomy is often difficult to perform in dialysis patients due to the associated risks related to surgery. In contrast, renal transcatheter arterial embolization (TAE) with metallic coils, which is a less invasive interventional procedure, can also be utilized to contract enlarged kidneys in dialysis patients as an effective treatment. However, metallic coils present the possibility of recanalization and cost issues. Thus, we used ethanol instead of coils in renal TAE to resolve these issues. We report a dialysis patient with enlarged polycystic kidneys and poor oral intake due to abdominal distention that was successfully treated by TAE with absolute ethanol

  6. Management of phenytoin induced gingival enlargement associated with cerebral palsy: A challenge to the clinician

    Directory of Open Access Journals (Sweden)

    Anupama Shriram Rao

    2013-01-01

    Full Text Available Phenytoin, which is the drug of choice for treatment of grandmal, psychomotor seizures associated with cerebral palsy, has serious side effect like gingival enlargement. Drug induced gingival enlargement is not only esthetically disfiguring but often impairs speech, mastication, nutrition and plaque control measures. In addition, poor oral hygiene, lack of motor coordination and muscular limitations in mentally disabled individuals results in increased susceptibility to periodontal disease. The present case report unfolds a complex nature of the management of phenytoin induced gingival enlargement, secondarily complicated by inflammation, and in the cerebral palsy patient. A supportive team work of periodontist, neurophysician, and general anesthetist plays a significant role in maintaining the quality of life in mentally disabled patient.

  7. Acceleration-Enlarged Symmetries in Nonrelativistic Space-Time with a Cosmological Constant

    CERN Document Server

    Lukierski, J; Zakrzewski, W J

    2007-01-01

    By considering the nonrelativistic limit of de-Sitter geometry one obtains the nonrelativistic space-time with a cosmological constant and Newton-Hooke (NH) symmetries. We show that the NH symmetry algebra can be enlarged by the addition of the constant acceleration generators and endowed with central extensions (one in any dimension (D) and three in D=(2+1)). We present a classical Lagrangian and Hamiltonian framework for constructing models quasi-invariant under enlarged NH symmetries which depend on three parameters described by three nonvanishing central charges. The Hamiltonian dynamics then splits into external and internal sectors with new non-commutative structures of external and internal phase spaces. We show that in the limit of vanishing cosmological constant the system reduces to the one presented in [1] which possesses accelaration-enlarged Galilean symmetries.

  8. Acceleration-enlarged symmetries in nonrelativistic space-time with a cosmological constant

    Energy Technology Data Exchange (ETDEWEB)

    Lukierski, J. [University of Wroclaw, Institute for Theoretical Physics, Wroclaw (Poland); University of Valencia, Department of Theoretical Physics, Burjassot (Valencia) (Spain); Zakrzewski, W.J. [University of Durham, Department of Mathematical Sciences, Durham (United Kingdom); Stichel, P.C.

    2008-05-15

    By considering the nonrelativistic limit of de Sitter geometry one obtains the nonrelativistic space-time with a cosmological constant and Newton-Hooke (NH) symmetries. We show that the NH symmetry algebra can be enlarged by the addition of the constant acceleration generators and endowed with central extensions (one in any dimension (D) and three in D=(2+1)). We present a classical Lagrangian and Hamiltonian framework for constructing models quasi-invariant under enlarged NH symmetries that depend on three parameters described by three nonvanishing central charges. The Hamiltonian dynamics then splits into external and internal sectors with new noncommutative structures of external and internal phase spaces. We show that in the limit of vanishing cosmological constant the system reduces to the one, which possesses acceleration-enlarged Galilean symmetries. (orig.)

  9. Nocturnal foraging enhanced by enlarged secondary eyes in a net-casting spider.

    Science.gov (United States)

    Stafstrom, Jay A; Hebets, Eileen A

    2016-05-01

    Animals that possess extreme sensory structures are predicted to have a related extreme behavioural function. This study focuses on one such extreme sensory structure-the posterior median eyes of the net-casting spider Deinopis spinosa. Although past research has implicated the importance of vision in the nocturnal foraging habits of Deinopis, no direct link between vision in the enlarged eyes and nocturnal foraging has yet been made. To directly test the hypothesis that the enlarged posterior median eyes facilitate visually based nocturnal prey capture, we conducted repeated-measures, visual occlusion trials in both natural and laboratory settings. Our results indicate that D. spinosa relies heavily on visual cues detected by the posterior median eyes to capture cursorial prey items. We suggest that the enlarged posterior median eyes benefit D. spinosa not only through increased diet breadth, but also by allowing spiders to remain active solely at night, thus evading predation by diurnal animals. PMID:27194291

  10. Lack of potassium channel induces proliferation and survival causing increased neurogenesis and two-fold hippocampus enlargement

    DEFF Research Database (Denmark)

    Almgren, Malin; Persson, Ann-Sophie; Fenghua, Chen;

    2007-01-01

    The megencephaly mice show dramatic progressive increase in brain size and seizures. The overgrowth affects primarily the hippocampus and ventral cortex. The phenotype originates from a mutation in the Shaker-like voltage-gated potassium channel Kv1.1 brain, which results in a malfunctioning...... protein. A key question in elucidating the mechanism behind the unique brain overgrowth is whether it is caused by an increase in cell number. By applying stereological techniques, we found that the number of both neurons and astrocytes, as well as structure volume, was increased approximately two...... lower in mceph/mceph supporting additional overgrowth mechanism than induced by seizures. In conclusion, lack of a functional Kv1.1 ion channel subunit in the mceph/mceph mice causes a unique neuronal hyperplasia in distinct hippocampal regions and consequently hippocampal enlargement from 2 to 3 weeks...

  11. NAD(P-DEPENDENT DEHYDROGENASE ACTIVITY IN PERIPHERAL BLOOD LYMPHOCYTES OF INFANTS WITH ENLARGEMENT OF PHARYNGEAL TONSILS

    Directory of Open Access Journals (Sweden)

    L. M. Kurtasova

    2014-08-01

    Full Text Available We have observed and examined 57 children 1 to 3 years old diagnosed with enlargement of pharyngeal tonsils. A control group was presented by 35 healthy children. Bioluminescence technique was applied for studying NAD(P-dependent dehydrogenase activity in peripheral blood lymphocytes. Activation of aerobic respiration and increasing activity of pentose phosphate cycle-dependent plastic processes were registered in blood lymphocytes of children with hypertrophic pharyngeal tonsils; along with decreased function of malate-aspartate shunt in energy metabolism of the cells, diminished anaerobic reaction of NADHdependent LDH, lower interaction between Krebs cycle and reactions of amino acid metabolism, and reduced activity of glutathione reductase.

  12. Eponyms related to genetic disorders associated with gingival enlargement; part II

    OpenAIRE

    Nora Mohammed Al-Aboud; Hanan Barnawi; Ahlam Al Hakami

    2015-01-01

    There are genetic disorders associated with gingival enlargement. In our part I, we reviewed the eponyms linked to Hereditary Gingival Fibromatosis (HGF) [1]. Historical Article How to cite this article: Al Aboud A, Al-Aboud NM, Barnawi H, Al Hakami A. Eponyms related to genetic disorders associated with gingival enlargement: Part II. Our Dermatol Online. 2015;6(1):114-117. Submission: 27.05.2013; Acceptance: 21.09.2014 DOI: 10.7241/ourd.20151.32 In this part II of thi...

  13. Cystic lymph node enlargement of the neck: filariasis as a rare differential diagnosis in MRI

    Energy Technology Data Exchange (ETDEWEB)

    Schick, Christoph; Thalhammer, Axel; Balzer, Joern O.; Abolmaali, Nasreddin; Vogl, Thomas J. [Department of Diagnostic and Interventional Radiology, University of Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt/Main (Germany)

    2002-09-01

    Cervical lymph node enlargement is a common feature of most inflammatory and neoplastic entities of the head and neck. Filariasis can lead to lymphangiectasis resembling lymph node enlargement; however, this is a rare differential diagnosis in European patients. As ethnic minorities are increasing throughout Europe and personal mobility, e.g. during holidays, is increasing, such rare differential diagnoses have to be taken into consideration. We present the case of an Iraqi patient referred to as for a suspected cystic lymph node mass that was verified histologically by open MRI biopsy and proved to be a cystic manifestation of filariasis. (orig.)

  14. Unusual presentation of localized gingival enlargement associated with a slow-growing odontogenic myxoma

    Institute of Scientific and Technical Information of China (English)

    Jaume Miranda Rius; Alfons Nadal; Eduard Lahor; Beatus Mtui; Llus Brunet

    2013-01-01

    Unusual presentation of localized gingival enlargement associated with a subjacent tumoural pathology is reported. The patient was a 55-year-old black male, whose chief complaint was a progressive gingival overgrowth for more than ten years, in the buccal area of the anterior left mandible. According to the clinical features and the radiological diagnosis of odontogenic keratocyst, a conservative surgery with enucleation and curettage was performed. Tissue submitted for histopathological analysis rendered the diagnosis of odontogenic myxoma. After 12-month of follow-up, no evidence of recurrence was found. Clinicians should be cautious when facing any gingival enlargement to avoid diagnostic pitfalls and to indicate the appropriate treatment.

  15. Clinical and morphological study of calf enlargement following S-1 radiculopathy

    OpenAIRE

    Nascimento, Osvaldo J.M.; Marcos R. G. de freitas; Myrian D. Hahn; Abelardo Q.C. Araújo

    1992-01-01

    Calf enlargement following sciatica is a rare condition. It is reported the case of a 28-year-old woman who complained of repeated episodes of lower back pain radiating into the left buttock and foot. One year after the beginning of her symptoms, she noticed enlargement of her left calf. X-ray studies disclosed L5-S1 disk degeneration. EMG showed muscle denervation with normal motor conduction velocity. Open biopsies of the gastrocnemius muscles were performed. The left gastrocnemius muscle s...

  16. Tax Co-ordination and the Enlargement of the European Union

    OpenAIRE

    Groenendijk, Nico S.

    1999-01-01

    In this paper the concept of tax co-ordination within the European Union (EU) is discussed, in view of the coming enlargement of the EU. The tax externalities that possibly arise in a single market are analysed, as well as the ways these externalities can be prevented or internalised. These theoretical reflections are placed alongside the actual system of tax co-ordination within the EU. Focusing on VAT and corporate taxation, the implications of enlargement of the EU for the tax co-ordinatio...

  17. THE EUROPEAN UNION, THE ENLARGEMENT AND THE SOUTH-EASTERN EUROPE

    OpenAIRE

    Malkidis Theofanis

    2005-01-01

    Ιn 1989, the countries of South-eastern Europe and central Europe promoted their integration of military, political and economic collaboration and developed narrow relations with the European Union (Ε.U). Thus resulted the new enlargement of EU, in order to transfer in south-eastern Europe the places of EU, for peace, stability, growth. The new enlargement constitutes a big challenge, after the integrations of states in the EU in 1973, in 1981, in 1986, in 1995 they did not have the extent ...

  18. Public opinion – a stumbling block to enlargement? : an analysis of the relation between costs and benefits of eastern enlargement and their perception in current EU member-states

    OpenAIRE

    Husz, Dora

    2003-01-01

    The present paper investigates how one factor, the public perception of costs and benefits of enlargement in the current EU member-states might play a role in influencing the form and the content of eastern enlargement. The core of the analysis is focused on the demonstration and explanation of discrepancies between the costs and benefits of eastern enlargement for the EU and their public perception in the current member-states.

  19. The Eastern Enlargement of the European Union : An Institutionalist Analysis of Policy Positions, Accession Scenarios and Institutional Reform

    OpenAIRE

    König, Thomas; Bräuninger, Thomas

    2003-01-01

    This study provides an institutionalist view of Eastern enlargement of the European Union by uncovering the enlargement preferences of all member states. Considering two accession scenarios and the Nice institutional reform, we analyze European Union decision-making in order to understand the transformation of the inter-institutional power relationship between the member states, the Commission and the Court of Justice. We find that most member states support a stepwise Eastern enlargement and...

  20. ASSESSING THE ROLE OF EU AGENCIES IN THE ENLARGEMENT PROCESS: THE CASE OF THE EUROPEAN AVIATION SAFETY AGENCY

    OpenAIRE

    Coman-Kund, Florin

    2012-01-01

    This paper examines from a legal perspective the modes in which EU agencies partake in the enlargement process. In so doing, first the main forms in which agencies become involved in EU enlargement are explored. Next, EU agencies’ forms of participation in the enlargement process are subjected to a legal assessment taking the principle of institutional balance and the delegation of powers within the EU as the main yardsticks. In this context, the legal nature of such forms of partici...

  1. Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling

    Directory of Open Access Journals (Sweden)

    P.J.C. Biselli

    2011-05-01

    Full Text Available Chronic obstructive pulmonary disease (COPD is associated with inflammatory cell reactions, tissue destruction and lung remodeling. Many signaling pathways for these phenomena are still to be identified. We developed a mouse model of COPD to evaluate some pathophysiological mechanisms acting during the initial stage of the disease. Forty-seven 6- to 8-week-old female C57/BL6 mice (approximately 22 g were exposed for 2 months to cigarette smoke and/or residual oil fly ash (ROFA, a concentrate of air pollution. We measured lung mechanics, airspace enlargement, airway wall thickness, epithelial cell profile, elastic and collagen fiber deposition, and by immunohistochemistry transforming growth factor-β1 (TGF-β1, macrophage elastase (MMP12, neutrophils and macrophages. We observed regional airspace enlargements near terminal bronchioles associated with the exposure to smoke or ROFA. There were also increases in airway resistance and thickening of airway walls in animals exposed to smoke. In the epithelium, we noted a decrease in the ciliated cell area of animals exposed to smoke and an increase in the total cell area associated with exposure to both smoke and ROFA. There was also an increase in the expression of TGF-β1 both in the airways and parenchyma of animals exposed to smoke. However, we could not detect inflammatory cell recruitment, increases in MMP12 or elastic and collagen fiber deposition. After 2 months of exposure to cigarette smoke and/or ROFA, mice developed regional airspace enlargements and airway epithelium remodeling, although no inflammation or increases in fiber deposition were detected. Some of these phenomena may have been mediated by TGF-β1.

  2. Technobabble: Why You Can't Just Enlarge a Digital Photograph.

    Science.gov (United States)

    Wilson, Bradley

    2000-01-01

    Offers information for student photojournalists describing how to work with photographs, scanners, software, and digital information to reduce and enlarge photographs for page layouts to achieve clear, precise images. Notes definitions and formulas. Includes two exercises to teach and practice these principles. (SR)

  3. Differential diagnosis of arachnoid cyst from subarachnoid space enlargement by phase-contrast cine MRI

    Institute of Scientific and Technical Information of China (English)

    于群; 孔祥泉; 刘定西

    2003-01-01

    Objectives To reveal the relationship of brain motion and cerebrospinal fluid (CSF) flow by phase-contrast cine MRI, and to evaluate this technique in differentiating between arachnoid cysts and subarachnoid space enlargement. Methods Using a phase-contrast cine MRI pulse sequence, we measured brain motion and CSF flow during the cardiac cycle in 10 healthy volunteers and 10 patients with MRI-suspected arachnoid cyst or subarachnoid space enlargement. CSF stroke volume curve was illustrated according to flow quantification, and time-signal intensity curve was traced. The two curves were compared. Results This study showed that brain motion was due to the volume difference between arterial and venous blood flow during a cardiac cycle, and thus drives CSF pulsation. Arachnoid cysts and subarachnoid space enlargement carried different curve patterns, demonstrating that phase-contrast MRI and flow quantification can be a useful and reliable technique for non-invasive evaluation of brain motion and CSF flow. Conclusion Arachnoid cysts can be successfully differentiated using phase-contrast cine MRI from subarachnoid space enlargement.

  4. "Offline": the 2004 European parliamentary elections on television news in the enlarged Europe

    NARCIS (Netherlands)

    C.H. de Vreese; S.A. Banducci; H.A. Semetko; H.G. Boomgaarden

    2005-01-01

    We outline the competitive television news market in the enlarged European Union (EU) and demonstrate the continued importance of traditional media, in particular television, in the context of proliferation in choice of news sources, including on-line news services. Drawing upon a content analysis o

  5. "Off-line": the 2004 European parliamentary elections on television news in the enlarged Europe

    NARCIS (Netherlands)

    Vreese, de Claes H.; Banducci, Susan A.; Semetko, Holli A.; Boomgaarden, Hajo G.

    2005-01-01

    We outline the competitive television news market in the enlarged European Union (EU) and demonstrate the continued importance of traditional media, in particular television, in the context of proliferation in choice of news sources, including on-line news services. Drawing upon a content analysis o

  6. Morphological analysis of enlarged ventricle on CT image, using multivariate analysis

    International Nuclear Information System (INIS)

    Multivariate analysis of enlarged cerebral ventricle on CT was undertaken to study the characteristics of ventricular morphology. Several ventricular segments of enlarged ventricle, defined on the basis of the study of normal group, were linearly measured on CT image. Then the discriminant analysis with the increase and decrease of variable was applied. The following are the results obtained. The error ratio of discrimination between pressure hydrocephalus and cerebral atrophy was 8.4 %, and between obstructive hydrocephalus and communicating hydrocephalus was 11.3 %. Ventricular segments were divided into three groups according to their character of enlargement: (1) the temporal horn and trigone are large in pressure hydrocephalus; (2) the hypothalamic segment of the third ventricle and the body of lateral ventricle are larger in obstructive hydrocephalus than in communicating hydrocephalus; (3) the anterior horn, cellae mediae at the level of the head of caudate nuclei and thalamic segment of the third ventricle are relatively large in cerebral atrophy and communicating hydrocephalus. The hypothalamic segment of the third ventricle assumes a round or oval shape in pressure hydrocephalus but a rectangular or teardrop shape in cerebral atrophy. These findings are contributory to pathological evaluation of ventricular enlargement. (author)

  7. An Efficient Image Enlargement Method for Image Sensors of Mobile in Embedded Systems

    Directory of Open Access Journals (Sweden)

    Hua Hua

    2016-01-01

    Full Text Available Main challenges for image enlargement methods in embedded systems come from the requirements of good performance, low computational cost, and low memory usage. This paper proposes an efficient image enlargement method which can meet these requirements in embedded system. Firstly, to improve the performance of enlargement methods, this method extracts different kind of features for different morphologies with different approaches. Then, various dictionaries based on different kind of features are learned, which represent the image in a more efficient manner. Secondly, to accelerate the enlargement speed and reduce the memory usage, this method divides the atoms of each dictionary into several clusters. For each cluster, separate projection matrix is calculated. This method reformulates the problem as a least squares regression. The high-resolution (HR images can be reconstructed based on a few projection matrixes. Numerous experiment results show that this method has advantages such as being efficient and real-time and having less memory cost. These advantages make this method easy to implement in mobile embedded system.

  8. Mediastinal lymph node enlargement on CT scans in idiopathic pulmonary fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Joong Mo; Im, Jung Gi; Yu, Kyu In; Kim, Hyeong Seog [Seoul National University College of Medicine, Seoul (Korea, Republic of); Kim, Dae Young [Chung Buk National University College of Medicine, Chungju (Korea, Republic of); Yu, Pil Mun [Dankuk University College of Medicine, Seoul (Korea, Republic of)

    1992-09-15

    The increase in size of lymph node on CT scan is the single most important finding of lymphadenopathy. The purpose of this study was to evaluate the size of mediastinal lymph nodes in patients with idiopathic pulmonary fibrosis with no evidence of malignancy or current infection. CT scans of 70 patients (16 with conventional CT and 54 with high-resolution CT) were assessed for lymph node size and location. The duration of symptoms, and the extent and pattern of the parenchymal lung disease on CT scans were correlated with lymph node enlargement. In 54 of 70 patients, more than one lymph nodes were large than 1-1.5 cm. The prevalence of node enlargement increased significant with a longer duration of symptom (p=0.001), large extent of the disease (p=0.043), and with a greater proportion of honeycomb pattern (p=0.033). Right paratracheal, subcarinal, right tracheobronchial, and paraesophageal nodes were the most common sites of node enlargement. In conclusion, mediastinal lymph node enlargement is common in patients with idiopathic pulmonary fibrosis and is more frequently seen in patients with a longer duration of clinical symptoms, greater extent of the disease, and with a larger proportion of honeycomb pattern.

  9. Mediastinal lymph node enlargement on CT scans in idiopathic pulmonary fibrosis

    International Nuclear Information System (INIS)

    The increase in size of lymph node on CT scan is the single most important finding of lymphadenopathy. The purpose of this study was to evaluate the size of mediastinal lymph nodes in patients with idiopathic pulmonary fibrosis with no evidence of malignancy or current infection. CT scans of 70 patients (16 with conventional CT and 54 with high-resolution CT) were assessed for lymph node size and location. The duration of symptoms, and the extent and pattern of the parenchymal lung disease on CT scans were correlated with lymph node enlargement. In 54 of 70 patients, more than one lymph nodes were large than 1-1.5 cm. The prevalence of node enlargement increased significant with a longer duration of symptom (p=0.001), large extent of the disease (p=0.043), and with a greater proportion of honeycomb pattern (p=0.033). Right paratracheal, subcarinal, right tracheobronchial, and paraesophageal nodes were the most common sites of node enlargement. In conclusion, mediastinal lymph node enlargement is common in patients with idiopathic pulmonary fibrosis and is more frequently seen in patients with a longer duration of clinical symptoms, greater extent of the disease, and with a larger proportion of honeycomb pattern

  10. The Post-enlargement European Order: Europe ‘United in Diversity’?

    Directory of Open Access Journals (Sweden)

    Paul Blokker

    2006-09-01

    Full Text Available The enlargement of the European Union has led to an increase of diversity within the European area. While the project of enlargement can be understood as one in which the European Union has sought to defend an exclusive understanding of European identity (a ‘Fortress Europe’, the combined process of enlargement and constitutionalisation can be seen to have ultimately contributed to an opening up as well as a rendering more contingent of the European project. The theoretical argument of the paper holds that the tendency towards this diversity and contingency is not reflected and difficult to deal with in some of the major theories on European integration. The argument is flanked by a substantive account which analyses the actual transformation of the European project. I conclude that the post-enlargement situation can indeed be more adequately described as one of diversity and openness rather than homogeneity and increasing unity. Nevertheless, the incorporation of diversity still leaves much to be desired, not in the least because of a ‘procedural’ interpretation of the deliberative mode. In order to effectively take difference into account, deliberation should include the recognition of difference and an emphasis on mutual understanding, rather than being focused on consensus-building.

  11. THE EUROPEAN UNION, THE ENLARGEMENT AND THE SOUTH-EASTERN EUROPE

    Directory of Open Access Journals (Sweden)

    Malkidis Theofanis

    2005-07-01

    Full Text Available Ιn 1989, the countries of South-eastern Europe and central Europe promoted their integration of military, political and economic collaboration and developed narrow relations with the European Union (Ε.U. Thus resulted the new enlargement of EU, in order to transfer in south-eastern Europe the places of EU, for peace, stability, growth. The new enlargement constitutes a big challenge, after the integrations of states in the EU in 1973, in 1981, in 1986, in 1995 they did not have the extent and the expectations 2004 and particularly the South-eastern Europe afterwards 2007. The article analyzes the course of integration of South-eastern Europe in the EU and analyzes the essential changes that are required, the transition in the free market economy, the creation of political system that will be based on the state of right and the respect the human and minorities’ rights, the political plurality and the multi-party system with democratic elections. The article supports that the enlargement in the South-eastern Europe is very important for the EU, enlargement that closes the Cold War, a hope for the common European region of peace, cooperation, democracy and development.

  12. Precise control of critical dimension shrinkage and enlargement by in-situ polysilicon etch

    Science.gov (United States)

    Linliu, Kung; Kuo, Mai-Rue

    2000-07-01

    The control of critical dimension shrinkage and enlargement of polysilicon line or space obtained precisely using in- situ process with different ratio of gas combination is investigate din this paper. A polysilicon line could be etched down to 0.054 micrometers from 0.22 micrometers of the original critical dimension (CD). The CD shrinking rate of polysilicon line is 2.48 nm per second per side. On the other hand, the space can also be trimmed down to 0.03 micrometers from the original CD of 0.3 micrometers . The CD enlarging rate of polysilicon rate is 0.421 nm per second per side using the present polymer deposition method. The factors that cause shrinkage and enlargement of CD are the etching of photoresist and the deposition of polymer on the surface of photoresist, respectively. The oxygen-rich gas is used for the shrinkage of CD and the fluorocarbon-rich gas is used for the enlargement of CD. Therefore, a critical dimension could not afforded by the present existed optical photolithography tool or method might probably be solved by alternative innovation such as the plasma dry etching technology.

  13. Misdiagnosis of otosclerosis in a patient with enlarged vestibular aqueduct syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Távora-Vieira Dayse

    2012-07-01

    Full Text Available Abstract Introduction In the present case we report on the mismanagement of a patient misdiagnosed with otosclerosis, who was subsequently found to have enlarged vestibular aqueduct syndrome bilaterally. This highlights the need to not only be vigilant in pre-operative assessment of otosclerosis but also in post-operative investigations of stapedectomy failures. Case presentation Our patient, a 56-year-old Caucasian Australian woman, lost the hearing in her right ear following a stapedectomy approximately 25 years ago. It is thought that preoperative imaging was not conducted, while an inadequate (unmasked audiogram was used to formulate the initial diagnosis of otosclerosis. The hearing in her left ear deteriorated to the point that a cochlear implant was now being considered for her right ear. Imaging performed as part of our pre-cochlear implant battery revealed bilateral enlarged vestibular aqueducts and thus the decision to proceed with a right cochlear implant was made following discussion with our patient and her family in regard to not only general surgical risks but specifically the remote risk that the surgical drilling required during the procedure could risk a deterioration of the hearing in her left ear because of the enlarged vestibular aqueduct on that side. Conclusions This report illustrates a case of misdiagnosis and mismanagement of bilateral enlarged vestibular aqueduct resulting in profound hearing loss. Fortunately our patient has been successfully implanted with a right cochlear implant with remarkable outcomes.

  14. Enlargement of locally resonant sonic band gap by using composite plate-type acoustic metamaterial

    International Nuclear Information System (INIS)

    We numerically investigate the propagation characteristics of Lamb waves in composite plate-type acoustic metamaterial constituted of one-side cylindrical stubs deposited on a two-dimensional binary locally resonant phononic plate. Numerical results show that, with the introduction of composite plate-type acoustic metamaterial, locally resonant band gap shifts to lower frequency, and a significant enlargement of the relative bandwidth by a factor of 3 can be obtained, compared to one-side locally resonant stubbed plates. We show that the band gap enlargement is attributed to the coupling between the local resonant Lamb modes of two-dimensional phononic plate and the resonant modes of the stubs. - Highlights: • An original composite plate-type locally resonant acoustic metamaterial is proposed. • A significant enlargement of the relative bandwidth by a factor of 3 can be obtained. • The band gap enlargement is attributed to the locally resonant complex effect. • The band gap is significantly dependent upon the geometrical parameters

  15. Diaphragmatic hernia and right-sided heart enlargement in a Florida manatee (Trichechus manatus latirostris).

    Science.gov (United States)

    Gerlach, Trevor J; de Wit, Martine; Landolfi, Jennifer A

    2012-10-01

    Postmortem evaluation of a Florida manatee (Trichechus manatus latirostris) revealed cold stress lesions and previous watercraft trauma that included broken ribs, a diaphragmatic hernia, an enlarged vena cava, and right-sided cardiomegaly. We discuss these findings and present a possible pathogenesis for the cardiomegaly. PMID:23060518

  16. Enlarged clitoris in wild polar bears (Ursus maritimus) can be misdiagnosed as pseudohermaphroditism

    DEFF Research Database (Denmark)

    Sonne, C; Leifsson, P S; Dietz, R;

    2004-01-01

    A 23-year-old female polar bear (Ursus maritimus) killed in an Inuit hunt in East Greenland on July 9, 1999 had a significantly enlarged clitoris resembling, in size, form and colour, those of previously reported 'pseudohermaphroditic' polar bears from Svalbard. It has been suggested that an enzyme...

  17. Impact of EU Enlargement on Business Environment of Small and Medium-Sized Enterprises in Slovakia

    OpenAIRE

    Ján Vravec; Marián Gál; Tomás Sabol

    2005-01-01

    The paper discusses the impact of EU enlargement on business environment in the Slovak Republic. Integration of Slovakia into EU has significantly influenced operating conditions for small and medium enterprises. Prosperity of small and medium enterprises depends mainly on their ability to adapt themselves to these new conditions.

  18. Cytochrome P450 2C9 gene polymorphism in phenytoin induced gingival enlargement: A case report

    Directory of Open Access Journals (Sweden)

    S. P. K. Kennedy Babu

    2013-01-01

    Full Text Available Gingival enlargement comprises any clinical condition in which an increase in the size of the gingiva is observed. Among the drugs that induce gingival enlargement, the antiepileptic agent phenytoin has been widely related to this condition. The Cytochrome P450(CYP superfamily is the most commonly involved enzymes in metabolism of drugs. Common coding region CYP variants that affects drug elimination and response has been studied in great detail. Pharmacogenetic influences on drug metabolism have been widely reviewed and gene polymorphism of cytochrome P450 2C9 appeared to be responsible for much of the interindividual variability on drug elimination. Genetic variation in the CYP2C9 gene can affect metabolism, leading to altered phenotypes. Individuals with poor metaboliser alleles of CYP2C9 gene were shown to have a reduced metabolism of phenytoin compared with wild-type alleles. Thus identification of patients genotype prior to anti-epileptic drug administration could potentially prevent higher serum drug concentrations leading to adverse side effects such as gingival enlargement. This case report addresses the influence of CYP2C9 genetic polymorphism on Phenytoin drug metabolism thereby causing gingival enlargement.

  19. Multidrug resistance 1 gene polymorphism in amlodipine-induced gingival enlargement

    Science.gov (United States)

    Naik, Kumaraswamy Naik Lambani Rama; Jhajharia, Kapil; Chaudhary, Roopam; Tatikonda, Aravind; Dhaliwal, Aprinderpal Singh; Kaur, Rose Kanwaljeet

    2015-01-01

    Gingival enlargement comprises any clinical condition in which an increase in the size of the gingiva is observed. It is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. Among calcium channel blockers, nifedipine causes gingival enlargement in about 10% of patients, whereas the incidence of amlodipine, a third-generation calcium channel blocker, induced gingival enlargement is very limited. Because the calcium antagonists, albeit to a variable degree, act as inhibitors of P-glycoprotein (P-gp), the gene product of multidrug resistance 1 (MDR1), and inflammation may modify P-gp expression. We hereby, report a case of amlodipine-induced gingival enlargement with MDR1 3435C/T polymorphism, associated with inflammatory changes due to plaque accumulation, in a 50-year-old hypertensive male patient. The genotype obtained for the polymorphism was a heteromutant genotype, thus supporting the contention that the MDR1 polymorphism may alter the inflammatory response to the drug. PMID:26015682

  20. NATO Enlargement.

    Science.gov (United States)

    Volker, Karen

    1998-01-01

    Reviews the history of the North Atlantic Treaty Organization (NATO) and describes the debate over expanding its membership. Includes a discussion of the process for adding NATO members and a copy of the treaty. Suggests several exercises to help students better understand the NATO-expansion debate. (DSK)

  1. Gingival Enlargement

    Science.gov (United States)

    ... explained after the dentist takes a thorough medical history and performs an oral examination. In rare cases, further tests such as blood studies or a biopsy may be necessary to determine the exact cause ...

  2. Accuracy of electrocardiographic criteria for atrial enlargement: validation with cardiovascular magnetic resonance

    Directory of Open Access Journals (Sweden)

    Manning Warren J

    2008-01-01

    Full Text Available Abstract Background Anatomic atrial enlargement is associated with significant morbidity and mortality. However, atrial enlargement may not correlate with clinical measures such as electrocardiographic (ECG criteria. Past studies correlating ECG criteria with anatomic measures mainly used inferior M-mode or two-dimensional echocardiographic data. We sought to determine the accuracy of the ECG to predict anatomic atrial enlargement as determined by volumetric cardiovascular magnetic resonance (CMR. Methods ECG criteria for left (LAE and right atrial enlargement (RAE were compared to CMR atrial volume index measurements for 275 consecutive subjects referred for CMR (67% males, 51 ± 14 years. ECG criteria for LAE and RAE were assessed by an expert observer blinded to CMR data. Atrial volume index was computed using the biplane area-length method. Results The prevalence of CMR LAE and RAE was 28% and 11%, respectively, and by any ECG criteria was 82% and 5%, respectively. Though nonspecific, the presence of at least one ECG criteria for LAE was 90% sensitive for CMR LAE. The individual criteria P mitrale, P wave axis 0.04s·mm were 88–99% specific although not sensitive for CMR LAE. ECG was insensitive but 96–100% specific for CMR RAE. Conclusion The presence of at least one ECG criteria for LAE is sensitive but not specific for anatomic LAE. Individual criteria for LAE, including P mitrale, P wave axis 0.04s·mm are highly specific, though not sensitive. ECG is highly specific but insensitive for RAE. Individual ECG P wave changes do not reliably both detect and predict anatomic atrial enlargement.

  3. Influence of the endodontic irrigation needle and root canal enlargement on endodontic cleaning efficacy

    Directory of Open Access Journals (Sweden)

    Livia Etchebehere de Loiola

    2011-04-01

    Full Text Available ntroduction: The irrigation of root canals aims to their cleaning and disinfection, improving endodontic treatment success. Objective: To investigate the influence of the diameter and type of irrigation needle and the root canal enlargement on the mechanical efficacy of endodontic irrigation. Material and methods: Twelve human single-rooted mandibular incisors were used. During some instrumentation stages (enlargement by #20, #30, and #40 K file, root canals were filled with radiographic contrast solution mixed to propyleneglycol and zinc oxide. Needles with different diameters and designs were employed: G1 – 23G and lateral opening; G2 – 22G and apical opening; G3 – 30G and lateral opening; G4 – 30G and apical opening. The needles were inserted up to resistance, with 1 mm step-back to avoid root canal obliteration. The irrigation was performed with 2 mL of distilled water. Before and after irrigation/aspiration, teeth were radiographed at bucco-lingual and mesiodistal direction, using a digital radiographic system. Then, root canal areas, before (filled by contrast solution and after irrigation (remnant of contrast solution, were submitted to image subtraction with Adobe Photoshop CS4 software. Subsequently, the areas were measured by Image Tool 3.0 software, allowing the obtaining of the cleaning percentage for each modality. Data were analysed byusing Anova and Tukey’s test. The level of significance was set at P < 0.05. Results: For all root canal enlargements, 30G needles (G3 e G4 presented a better cleaning efficacy. In all groups, higher cleaning efficacy percentage was observed at #30 and #40 K file enlargement. Conclusion: Regardless their design, thinner needles were more effective; a better cleaning efficacy occurred in more enlarged root canals.

  4. Insulation co-ordination and the enlargement law for the GM counter tube

    Directory of Open Access Journals (Sweden)

    Dolićanin Edin Ć.

    2016-01-01

    Full Text Available In this paper we analyze application of contemporary methods of insulation co-ordination and the enlargement law in designing a GM counting tube. It has been shown that by applying insulation co-ordination methods the counting tube can be optimally dimensioned. The application of the enlargement law was demonstrated in generalizing the results of test obtained by the GM tube to those obtained by the counting tube with m-times greater dimensions. The investigations were conducted both theoretically and by experiment. Using theoretical analysis, we derived the expressions that may be applied if a performance function of a random variable breakdown voltage is known. The experiments were conducted on a GM counter model under well controlled laboratory conditions.

  5. Parotid enlargement due to adenovirus infection in patient with human immunodeficiency virus infection

    Directory of Open Access Journals (Sweden)

    Maria Irma Seixas Duarte

    1996-10-01

    Full Text Available The authors report a case of adenovirus- induced enlargement of the parotid gland involving a patient infected with human immunodeficiency virus (HIV. Physical examination revealed good general condition, no fever and bilateral enlargement of the parotid region, which was of increased consistency and slightly tender to palpation. Histological examination of the parotid gland demonstrated a slight periductal lymphomononuclear inflammatory infiltrate with the presence of focal points of necrosis. Tests to determine the presence of fungi and alcohol-acid resistent bacilli were negative. Immunohistochemistry for cytomegalovirus, heipes simplex, HIV p24 antigen and adenovirus showed positivity only for adenovirus in the epithelial nuclei of numerous gland ducts. Tins is the third case of this type reported in the literature, indicating the importance of including adenovirus in the differential diagnosis of this condition.

  6. Clinical and morphological study of calf enlargement following S-1 radiculopathy.

    Science.gov (United States)

    Nascimento, O J; De Freitas, M R; Hahn, M D; Araújo, A Q

    1992-09-01

    Calf enlargement following sciatica is a rare condition. It is reported the case of a 28-year-old woman who complained of repeated episodes of lower back pain radiating into the left buttock and foot. One year after the beginning of her symptoms, she noticed enlargement of her left calf. X-ray studies disclosed L5-S1 disk degeneration. EMG showed muscle denervation with normal motor conduction velocity. Open biopsies of the gastrocnemius muscles were performed. The left gastrocnemius muscle showed hypertrophic type 2 fibers in comparison with the right gastrocnemius. Electron microscopy showed mildly increased number of mitochondria in these fibers. A satisfactory explanation for denervation hypertrophy has yet to be provided. PMID:1308420

  7. Clinical significance of ventricular enlargement and cortical atrophy in computed tomography of the brain

    Energy Technology Data Exchange (ETDEWEB)

    Busse, O.; Agnoli, A.L.; Lippmann, R.; Schuetz, H.J.

    1981-02-01

    The diagnosis of atrophy of the brain based on the visual interpretation of CT findings appears questionable. In 56 patients there was no correlation between the CT findings of enlarged ventricles and sulci and clinical findings of psychoorganic syndromes. Only the group of 60 to 80 year old patients showed a statistically significant correlation between psychoorganic findings and the area of the lateral ventricles - measured planimetrically - and the diameter of the cella medica, but not the group of the 40 to 60 year old. There was no relationship between the number of cortical sulci and psychopathology. The morphological findings of ventricular enlargement and cortical atrophy in CT - even with exact measurements - do not allow any conclusions in regard to psychoorganic findings.

  8. The clinical significance of ventricular enlargement and cortical atrophy in computed tomography of the brain

    International Nuclear Information System (INIS)

    The diagnosis of atrophy of the brain based on the visual interpretation of CT findings appears questionable. In 56 patients there was no correlation between the CT findings of enlarged ventricles and sulci and clinical findings of psychoorganic syndromes. Only the group of 60 to 80 year old patients showed a statistically significant correlation between psychoorganic findings and the area of the lateral ventricles - measured planimetrically - and the diameter of the cella medica, but not the group of the 40 to 60 year old. There was no relationship between the number of cortical sulci and psychopathology. The morphological findings of ventricular enlargement and cortical atrophy in CT - even with exact measurements - do not allow any conclusions in regard to psychoorganic findings. (orig.)

  9. Clinical and morphological study of calf enlargement following S-1 radiculopathy

    Directory of Open Access Journals (Sweden)

    Osvaldo J. M. Nascimento

    1992-09-01

    Full Text Available Calf enlargement following sciatica is a rare condition. It is reported the case of a 28-year-old woman who complained of repeated episodes of lower back pain radiating into the left buttock and foot. One year after the beginning of her symptoms, she noticed enlargement of her left calf. X-ray studies disclosed L5-S1 disk degeneration. EMG showed muscle denervation with normal motor conduction velocity. Open biopsies of the gastrocnemius muscles were performed. The left gastrocnemius muscle showed hypertrophic type 2 fibers in comparison with the right gastrocnemius. Electron microscopy showed mildly increased number of mitochondria in these fibers. A satisfactory explanation for denervation hypertrophy has yet to be provided.

  10. Stochastic control under progressive enlargement of filtrations and applications to multiple defaults risk management

    CERN Document Server

    Pham, Huyen

    2010-01-01

    We formulate and investigate a general stochastic control problem under a progressive enlargement of filtration. The global information is enlarged from a reference filtration and the knowledge of multiple random times together with associated marks when they occur. By working under a density hypothesis on the conditional joint distribution of the random times and marks, we prove a decomposition of the original stochastic control problem under the global filtration into classical stochastic control problems under the reference filtration, which are determined in a finite backward induction. Our method revisits and extends in particular stochastic control of diffusion processes with finite number of jumps. This study is motivated by optimization problems arising in default risk management, and we provide applications of our decomposition result for the indifference pricing of defaultable claims, and the optimal investment under bilateral counterparty risk. The solutions are expressed in terms of BSDEs involvin...

  11. Liberalization and enlargement: effects of the industrial organisation of natural gas markets in Eastern Europe

    International Nuclear Information System (INIS)

    After half a century of political division within the European continent, and of State control over national energy industries, a new industrial and political organisation model aiming at creating a single natural gas market tends to emerge currently within the enlarged European Union. Yet new member countries are former centrally planned, socialist economies, with very different industrial structures for natural gas. However, those countries should adjust to the institutional framework applicable in the European Union, including bringing their gas industries into compliance with the liberalization process that old member countries initiated years ago. In that unprecedented context, one basic issue is whether the gas industry liberalization, in the framework of the enlargement, will have expected results in terms of competition, efficiency and profits for Eastern countries, whether new members or candidates for membership. The objective of the research work behind this article was to analyse the effects of that complex trend on the industrial organisation of gas markets in eastern Europe. (author)

  12. Impact of the European Union enlargement on health professionals and health care systems.

    Science.gov (United States)

    Avgerinos, Efthimios D; Koupidis, Sotirios A; Filippou, Dimitrios K

    2004-09-01

    As the European family enlarges, the admission of new human resources in the health services will have an impact on the European market and health care system. Under the umbrella of the European Union (EU) equality, the educational quality barriers (e.g. PLAB test in UK, DIKATSA test in Greece) will be abolished. The overproduction of health professionals and their heterogeneous regional and per specialty distribution will lead to medical unemployment and demotion of the medical profession. Medical and political authorities and decision makers of the EU need to reform the European Health System, supervise, and assess the quality of medical education, harmonize the individual National Health System policies, and follow the World Health Organization (regional office for Europe) guidelines on health policy. An agreed, structured European Health Policy might moderate the vibrations of the forthcoming EU enlargement. PMID:15276318

  13. Improving the Effect and Efficiency of FMD Control by Enlarging Protection or Surveillance Zones

    DEFF Research Database (Denmark)

    Hisham Beshara Halasa, Tariq; Toft, Nils; Boklund, Anette

    2015-01-01

    An epidemic of foot-and-mouth disease (FMD) in a FMD-free country with large exports of livestock and livestock products would result in profound economic damage. This could be reduced by rapid and efficient control of the disease spread. The objectives of this study were to estimate the economic...... impact of a hypothetical FMD outbreak in Denmark based on changes to the economic assumptions of the model, and to investigate whether the control of an FMD epidemic can be improved by combining the enlargement of protection or surveillance zones with pre-emptive depopulation or emergency vaccination....... The stochastic spatial simulation model DTU-DADS was used to simulate the spread of FMD in Denmark. The control strategies were the basic EU and Danish strategy, pre-emptive depopulation, suppressive or protective vaccination, enlarging protection or surveillance zones, and a combination of pre...

  14. Enlargement of mitral valve ring in a young woman with severe prosthesis-patient mismatch.

    Science.gov (United States)

    Attisani, Matteo; Pellegrini, Augusto; Sorrentino, Paolo; Rinaldi, Mauro

    2014-04-01

    Mechanical prosthesis is the first choice for valve replacement at the mitral position in children. Replacement of the original prosthesis because of prosthesis-patient mismatch (PPM) is almost inevitable when prostheses are implanted in small children. The impact of PPM on long-term mortality becomes significant when the effective orifice area (EOA) is severely reduced. In these cases prosthesis replacement can be technically difficult, and it often requires extended enlargement of the mitral valve annulus ring. We report a case of a woman who underwent a mitral valve replacement with a 19-mm St. Jude mechanical prosthetic valve at the age of 3 years. At the age of 33 years, the patient underwent a successful minimally invasive mitral annulus ring enlargement and implantation of a 23-mm St. Jude mechanical prosthetic valve via a right minithoracotomy. PMID:24808442

  15. Micro‐CT analyses of apical enlargement and molar root canal complexity

    DEFF Research Database (Denmark)

    Markvart, M.; Darvann, Tron Andre; Larsen, P.;

    2012-01-01

    Markvart M, Darvann TA, Larsen P, Dalstra M, Kreiborg S, Bjørndal L. Micro‐CT analyses of apical enlargement and molar root canal complexity. International Endodontic Journal, 45, 273–281, 2012. Aim To compare the effectiveness of two rotary hybrid instrumentation techniques with focus on apical...... enlargement in molar teeth and to quantify and visualize spatial details of instrumentation efficacy in root canals of different complexity. Methodology Maxillary and mandibular molar teeth were scanned using X‐ray microcomputed tomography. Root canals were prepared using either a GT/Profile protocol or a Ra......Ce/NiTi protocol. Variables used for evaluation were the following: distance between root canal surfaces before and after preparation (distance after preparation, DAP), percentage of root canal area remaining unprepared and increase in canal volume after preparation. Root canals were classified according to size...

  16. Modernization and enlarging of the Marcoule pilot plant for R and D

    International Nuclear Information System (INIS)

    The aim of the pilot plant is the testing of process and equipment in actual conditions with spent fuels on a half-industrial scale and for a significant time. From 1963 to 1983 more than 11t of spent fuels (mainly from fast reactors) were reprocessed. Since 1983 is modernized and enlarged and the new plant of the TOR project (treatment of oxides from fast reactors) are described

  17. Enlarging bilateral femoral condylar bone cysts without scintigraphic uptake in a yearling foal

    International Nuclear Information System (INIS)

    Bilateral subchondral bone cysts of the femoral condyles were diagnosed by conventional radiography in a 14 month old Appaloosa colt. Surgical debridement was performed, and over the next 18 months the appearance of the cysts was evaluated with radiography and bone scintigraphy. On the preoperative scintigrams, increased radiopharmaceutical uptake was associated with the cysts. Despite continued radiographic enlargement, the cysts did not demonstrate increased radiopharmaceutical uptake post-operatively

  18. Solid-phase distribution in an airlift reactor with an enlarged degassing zone

    OpenAIRE

    Freitas, Carla Maria Duarte de; Teixeira, J.A.

    1998-01-01

    The distribution of the solid-phase in an airlift reactor of the concentric draught tube type, with an enlarged degassing zone, has been determined. Samples were taken at eight points of the reactor for various airflow rates, solids loading and density. Hold-up of solids varied considerably within the reactor. The highest value, for all tested experimental conditions, was obtained immediately above the top of the riser and the lowest value near the wall of the degassing zone.

  19. Migration Strategies of the Crisis-Stricken Youth in an Enlarged European Union

    OpenAIRE

    Kahanec, Martin; Fabo, Brian

    2013-01-01

    This paper studies the migration response of the youth from new EU member states to disparate conditions in an enlarged European Union at the onset of the Great Recession. We use the Eurobarometer data and probabilistic econometric models to identify the key drivers of the intention to work in another member state of European Economic Area (EEA) and their expected duration. We find that migration intentions are high among those not married and among males with children, but both categories ar...

  20. Socio-economic efects of the Labor Force Migration in an enlarged Europe*

    OpenAIRE

    Nicolae, Mariana; Radu, Bridusa Mihaela

    2007-01-01

    The enlargement of the European Union and the liberalization of labor force movement to Europe increase greatly the migration towards the developed countries. This phenomenon affects the economic growth both on short and long term. The ascending trend of migration began in the mid nineties and continued after 2000. The data between 2002 and 2005 indicate a quasi-slowdown tendency. This paper aims to estimate some effects of migration flows on both the origin countries and the host countries i...

  1. EU enlargement : what does it change for the european economic geography

    OpenAIRE

    Mouhoud, El Mouhoub; Jennequin, Hugues; Dupuch, Sébastien

    2004-01-01

    This paper evaluates the effects of the enlargement of the EU to the Central and Eastern European Countries (CEECs), focusing on agglomeration and industrial specialisation patterns in Europe. We first present the theoretical debate based on the New Economic Geography models. The outcome is that, in spite of the lack of labour mobility within the EU, a core periphery schema is expected to occur as a result of vertical linkages. Then, we provide evidence on real and structural convergence and ...

  2. Measuring the Financial markets' perception of EMU enlargement:the role of ambiguity aversion

    OpenAIRE

    Cincibuch, Martin; Horníková, Martina

    2007-01-01

    Market views on EMU enlargement are measured by a new indicator based on the short-term dynamics of forward spreads. Conceptually, this indicator stems from the notion of ambiguity-averse agents in the sense of Knight. Specifically, we attempt to operationalize the incomplete preferences framework, which may allow for multiple equilibria supported by one set of fundamentals. This equilibrium indeterminacy may offer a way to reconcile short-term fluctuations of market prices with a relatively ...

  3. Labour mobility in the enlarged European Union: International migration from the EU8 countries

    OpenAIRE

    Fihel, Agnieszka; Kaczmarczyk, Paweł; Okólski, Marek

    2006-01-01

    The present paper consists of an extensive description of recent migration in the 8 new European Union member countries which accessed the EU on May 1st, 2004. Since 1989 all of these countries experience an unique shift from socialist to market economy. The paper attempts to capture an interplay or correlation of pre- and post-enlargement developments with the phenomena of political and socio-economic transition on migration from and into this region.

  4. Acute Unilateral Parotid Glands Enlargement Following Endotracheal General Anesthesia: Report of Two Cases

    OpenAIRE

    Hung-Jr Chiou; Yuan-Ji Day; Allen H. Li; Jiin-Tarng Liou; Fu-Chao Liu

    2007-01-01

    Acute parotid gland enlargement in association with general anesthesia is rare and hasalso been called anesthesia mumps. We present two patients who were scheduled for lumbarspine surgery under general anesthesia. Each developed acute unilateral parotid glandenlargement over one side of the face proven by sonography. Case 1: A 52-year-old manwas scheduled for his third lumbar spine to first sacral spine surgery for scoliosis andspondylolisthesis. The patient was provided general anesthesia wi...

  5. CONNECTING THE ENLARGEMENT PROCESS WITH THE EUROPEANIZATION THEORY (THE CASE OF TURKEY)

    OpenAIRE

    Teodor Lucian Moga

    2010-01-01

    Europeanization is one of the theoretical instruments which had a vital influence on candidate countries for EU membership. Due to its aspirations of becoming member of the European Union (EU) and in its attempt to fulfil the Copenhagen criteria, Turkey is trying to comply with the EU acquis communautaire. The aim of this paper is to assess the effects of the Europeanization process on the countries subject to EU enlargement strategy, with a special focus on Turkey, particularly since the cou...

  6. Portugal and the EU’s Eastern Enlargement: A logic of identity endorsement

    OpenAIRE

    Schukkink, Martijn; Niemann, Arne

    2012-01-01

    This paper addresses the puzzle of why Portugal has consistently supported the EU’s fifth enlargement. We argue that standard explanations, based on welfare maximisation, geopolitics, or rhetorical action, cannot persuasively account for this policy choice. Instead, we advance an alternative explanation – subsequently referred to as ‘identity endorsement –that is based on a logic of appropriateness where behaviour is shaped by aspects of similarity and congruence, and where the development of...

  7. Inhibitory effects by ayurvedic plants on prostate enlargement induced in rats

    OpenAIRE

    Rahul K Dumbre; Manisha B Kamble; Patil, Vijay R.

    2014-01-01

    Background: Ayurveda recommends several plants and plant preparation for conditions of urogenital disorders as per its principles. Objectives: Ayurvedic plants Tamala (Cinnamomum tamala); Daruhalad (Berberis aristata); Ativish (Aconitum heterophyllum) were studied for mechanisms of prostatic hyperplasia induced in rats. Materials and Methods: Prostatic enlargement was induced in castrated rats by testosterone injection s.c. for 21 days and simultaneously plants were dosed orally daily. On day...

  8. Genetic Determinants of Metabolism and Benign Prostate Enlargement: Associations with Prostate Volume

    OpenAIRE

    Giri, Ayush; Edwards, Todd L.; Motley, Saundra S.; Byerly, Susan H.; Fowke, Jay H.

    2015-01-01

    Prostate enlargement leading to clinical benign prostatic hyperplasia (BPH) is associated with metabolic dysregulation and obesity. The genetic basis of this association is unclear. Our objective was to evaluate whether single nucleotide polymorphisms (SNPs) previously associated with metabolic disorders are also associated with prostate volume (PV). Participants included 876 men referred for prostate biopsy and found to be prostate cancer free. PV was measured by transrectal ultrasound. Samp...

  9. EU Enlargement – Gains With or Without Membership

    OpenAIRE

    Arnswald, Ulrich [Rez.

    2001-01-01

    Enlargement is one of the greatest opportunities for the European Union (EU) at the beginning of the 21st century. So far, thirteen applicant states are waiting ante portas: Bulgaria, Cyprus, the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Malta, Poland, Romania, the Slovak Republic, Slovenia and Turkey. The peaceful integration of these societies from across the whole continent is a unique historic, political, and socio-economic opportunity. Extending security and political stabilit...

  10. Blood Flow Simulations for the Design of Stented Valve Reducer in Enlarged Ventricular Outflow Tracts

    OpenAIRE

    Caiazzo, Alfonso; Guibert, Romain; Boudjemline, Younes; Vignon-Clementel, Irene

    2015-01-01

    International audience Tetralogy of Fallot is a congenital heart disease characterized over time, after the initial repair, by the absence of a functioning pulmonary valve, which causes regurgitation, and by progressive enlargement of the right ventricle outflow tract (RVOT). Due to this pathological anatomy, available transcatheter valves are usually too small to be deployed there. To avoid surgical valve replacement, an alternative consists in implanting a reducer prior to or in combinat...

  11. Welfare State Formation in the Enlarged European Union: Patterns of Reform in Postcommunist States

    OpenAIRE

    Offe, Claus; Fuchs, Susanne

    2007-01-01

    Eastern Enlargement of the European Union challenged the design of European Welfare states. Many authors discuss the impact of East European social security systems on their West European counterparts and fear a “race to the bottom”. This paper addresses welfare state developments in the eight post-socialist new member states which completed the accession process in 2004, Estonia, Latvia, Lithuania, Poland, the Czech Republic, Slovakia, Hungary, and Slovenia (EU-8). We focus on institutional ...

  12. Confidence and Unemployment in the European Union: A lesson from the 2004 enlargement

    OpenAIRE

    António Caleiro

    2007-01-01

    We use data for the monthly unemployment rate and consumer confidence indicator in the European Union to study whether there is a relationship between unemployment and confidence. Our estimation method is based on a fuzzy logic methodology with a Gaussian membership function. We find a stronger relationship between unemployment and confidence than it is apparent. We show in an ex-post prediction study that this relationship did not change, in a significant way, after the 2004 enlargement of t...

  13. The Enlargement of the European Union and the Redistribution of Seigniorage Wealth

    OpenAIRE

    Feist, Holger

    2001-01-01

    In the course of the EU enlargement process, the participation of accession countries in the European Monetary Union might lead to a significant redistribution of seigniorage wealth if current regulations prevail. In general, accession countries will be winners from this redistribution, for example Poland with 12.9 billion euros, Romania with 9.9 billion euros or Hungary with 3.3 billion euros. Correspondingly, the current member countries of the European Union face costs of 35.3 billion euro...

  14. EMU, EU Enlargement, and the European Social Model: Trends, Challenges, and Questions

    OpenAIRE

    Kittel, Bernhard

    2002-01-01

    The paper discusses the possible implications of the challenges facing the “European Social Model” (ESM) caused by the European Monetary Union (EMU) and the enlargement of the EU to include central and eastern European countries. The strains produced by the two challenges on the European welfare states and industrial relation systems are regarded as considerable, adding to the wide variety of country-specific solutions and leading to increased inequality both across and within member countrie...

  15. Misdiagnosis of otosclerosis in a patient with enlarged vestibular aqueduct syndrome: a case report

    OpenAIRE

    Távora-Vieira Dayse; Miller Stuart

    2012-01-01

    Abstract Introduction In the present case we report on the mismanagement of a patient misdiagnosed with otosclerosis, who was subsequently found to have enlarged vestibular aqueduct syndrome bilaterally. This highlights the need to not only be vigilant in pre-operative assessment of otosclerosis but also in post-operative investigations of stapedectomy failures. Case presentation Our patient, a 56-year-old Caucasian Australian woman, lost the hearing in her right ear following a stapedectomy ...

  16. CT appearance of hilar and mediastinal enlarged lymph nodes of coal worker's pneumoconiosis

    International Nuclear Information System (INIS)

    Objective: To study the CT appearance of the hilar and mediastinal enlarged lymph nodes in coal worker's pneumoconiosis (CWP), its pathological basis and diagnostic value for CWR complicated with lung cancer. Methods: (1) Twelve isolated lungs with CWP obtained at autopsy were inflated and fixed. CT scan was performed. The pathologic findings of enlarged lymph nodes were identified. (2) CT findings of hilar and mediastinal enlarged lymph nodes of 71 cases with CWP and 22 cases of CWP complicated with lung cancer were analyzed. Results: (1) Most of the enlarged hilar and mediastinal lymph nodes in simple CWR was in third stage of fibrosis. The fourth stage of fibrosis was only seen in lymph nodes of a case with complicated CWP. In this case the necrotic materials of lymph nodes eroded adjacent bronchi and vessels, and coalesced with progressive massive fibrosis (PMF). (2) The average number of lymph nodes in cases of complicated CWP was more than that of simple CWP (P 2 cm was 7.4%. (3) The prevalence of lymph nodes calcification in CWP was 61.1%, but egg shell calcification was only 14.7%. (4) In the cases of CWP complicated with lung cancer, lymph node > 2 cm was 20.8%, that was more than CWP (P3 cm was 7.6%. Conclusion: Lymph nodes up to 1 cm may have dust fibrosis and coal silicosis nodules. The lymph nodes >2 cm is more common in CWP complicated with lung cancer than in simple CWP. The lymph nodes > 3 cm indicates higher probability of CWP with lung cancer than PMF

  17. Morphology and morphometry of the human sublingual glands in mouth floor enlargements of edentulous patients

    OpenAIRE

    Josiane Costa Rodrigues de SA; TOLENTINO, Elen de Souza; Luciana Reis AZEVEDO-ALANIS; IWAKI FILHO, Liogi; LARA, Vanessa Soares; Jose Humberto DAMANTE

    2013-01-01

    Asymptomatic mouth floor enlargements may be observed in edentulous patients. These masses, which protrude from the mouth floor, may complicate the fitting of dentures and require surgery. Whether this "entity" may be considered an anatomical variation of the mouth floor or represent specific alterations in the sublingual gland is not known. Objective: The aim of this work is to investigate the morphological and morphometric aspects of the sublingual glands of edentulous patients with mout...

  18. Clinical correlates of enlarged prostate size in subjects with sexual dysfunction

    Directory of Open Access Journals (Sweden)

    Giovanni Corona

    2014-10-01

    Full Text Available Digito-rectal examination (DRE of the prostate provides useful information on the state of prostate growth and on the presence of suspected peripheral nodules. The aim of this study is to describe the clinical and biochemical correlates of finding an enlarged prostate size at DRE in subjects with sexual dysfunction (SD. A consecutive series of 2379 patients was retrospectively studied. The analysis was focused on a subset of subjects (n = 1823; mean age 54.7 ± 11.4 selected for being free from overt prostatic diseases. Several parameters were investigated. After adjusting for confounders, the presence of an enlarged prostate size at DRE was associated with a higher risk of metabolic syndrome (HR = 1.346 (1.129-1.759; P = 0.030, type 2 diabetes mellitus (HR = 1.489 (1.120-1.980; P = 0.006, increased LDL cholesterol (>100 mg dl−1 ; HR = 1.354 (1.018-1.801; P = 0.037 and increased mean blood pressure (BP values (HR = 1.017 (1.007-1.027 for each mmHg increment; P = 0.001. Accordingly, enlarged prostate size was also associated with a higher risk of arteriogenic erectile dysfunction (ED, as well as with other andrological conditions, such as varicocele and premature ejaculation (PE. PSA levels were significantly higher in subjects with enlarged prostate size when compared to the rest of the sample (HR = 3.318 (2.304; 4.799 for each log unit increment in PSA levels; P < 0.0001. Arteriogenic ED, according to different criteria, was also associated with increased PSA levels. In conclusion, our data support the need to examine prostate size either by clinical (DRE or biochemical (PSA inspection in subjects with SD, in order to have insights into the nature of the SD and the metabolic and cardiovascular (CV background of the patient.

  19. An enlarged postcranial sample confirms Australopithecus afarensis dimorphism was similar to modern humans

    OpenAIRE

    Reno, Philip L.; McCollum, Melanie A.; Meindl, Richard S.; Lovejoy, C. Owen

    2010-01-01

    In a previous study, we introduced the template method as a means of enlarging the Australopithecus afarensis postcranial sample to more accurately estimate its skeletal dimorphism. Results indicated dimorphism to be largely comparable to that of Homo sapiens. Some have since argued that our results were biased by artificial homogeneity in our Au. afarensis sample. Here we report the results from inclusion of 12 additional, newly reported, specimens. The results are consistent with those of o...

  20. Enlargement of the narrow aortic root and oblique insertion of a St Jude prosthesis.

    OpenAIRE

    Kinsley, R H; Antunes, M J; McKibbin, J K

    1983-01-01

    The aortic root was enlarged and a St Jude Medical valve obliquely inserted in 11 patients. Prosthetic valve sizes at least one, but often two, sizes larger than that which would normally be accommodated by the dimensions of the host aortic annulus were used. Closure of the valve was not affected by obliquity. This simple technique is recommended whenever the host aortic annulus does not allow the insertion of a substitute valve of an appropriate size.

  1. Amygdala enlargement in patients with mesial temporal lobe epilepsy without hippocampal sclerosis

    Directory of Open Access Journals (Sweden)

    AnaCarolinaCoan

    2013-10-01

    Discussion: This exploratory study demonstrates the occurrence of AE in 12% of patients with MTLE-NL. This finding supports the hypothesis that there might be a subgroup of patients with MTLE-NL in which the enlarged amygdala could be related to the epileptogenic process. Further studies are necessary but this finding could be of great importance in the understanding of MTLE-NL.

  2. Poles Apart? EU Enlargement and the Labour Market Outcomes of immigrants in the UK

    OpenAIRE

    Drinkwater, Stephen; Eade, John; Garapich, Michal

    2006-01-01

    The UK was one of only three countries to allow migrants from accession countries to enter their labour markets more or less without restriction following EU enlargement in May 2004. Therefore, it is important to establish the characteristics and labour market performance of migrants from these countries who have subsequently entered the UK. We principally analyse Labour Force Survey data to compare the labour market outcomes of recent migrants from Poland and other accession countries to tho...

  3. Czech Republic in the Context of Europe: Post-Enlargement Successes and Failures

    Czech Academy of Sciences Publication Activity Database

    Mansfeldová, Zdenka; Guasti, Petra

    Budapešť : Budapest College of Communication and Business , 2013 - (Attila, A.; László, V.), s. 269-299 ISBN 978-963-88943-5-9 R&D Projects: GA MŠk 7E12022 Institutional support: RVO:68378025 Keywords : institutional development * enlargement * europeanization Subject RIV: AD - Politology ; Political Sciences http://www.academia.edu/4036963/22._European_Futures_The_Perspectives_of_the_New_Member_States_in_the_New_Europe

  4. An Ultrasensitive Chemiluminescence Biosensor for Carcinoembryonic Antigen Based on Autocatalytic Enlargement of Immunogold Nanoprobes

    OpenAIRE

    2012-01-01

    A sensitive flow injection chemiluminescence assay for carcinoembryonic antigen (CEA) detection based on signal amplification with gold nanoparticles (NPs) is reported in the present work. The sandwich system of CEA/anti-CEA/goat-anti-mouse IgG functionalized Au nanoparticles was used as the sensing platform. In order to improve detection sensitivity, a further gold enlargement step was developed based on the autocatalytic Au deposition of gold nanoprobes via the reduction of AuCl4 − to Au0 o...

  5. Reversible and non-reversible enlargement of cerebral spinal fluid spaces in anorexia nervosa

    International Nuclear Information System (INIS)

    Brain CT studies of 35 patients with anoxia nervosa confirmed the observations of other authors: cerebral dystrophic changes correlate with weight loss and the reversibility of these changes also correlates with the normalization of body weight. Other corroborated facts are: the most numerous and most pronounced enlargements are of the cortical sulci and the interhemispheric fissure, moderate widening affects the ventricles and the rarest and most insignificant changes are those of the cerebellum. The reversibility of the changes showed a parallel to the extent of the changes themselves and to the duration of improvement of the body weight. The reversibility of the enlargement of the cortical sulci and of the distances between the frontal horns of the lateral ventricles was more often significant than that of the abnormal measurements of the cella media. This difference is based on minimal early acquired brain damage which occurs in 60% of our patients. This high incidence of early acquired minimal brain disease in patients with anorexia nervosa is here discussed as a nonspecific predisposing factor. Although there is no exact explanation of the etiology of the reversible enlargement of cerenral spinal fluid (CSF) spaces in anorexia nervosa, the changes resemble those in alcoholics. The mechanisms of brain changes in alcoholism, as shown experimentally, seem to us to throw light on the probable mechanism of reversible dystrophic brain changes in anorexia nervosa. (orig.)

  6. Channel enlargement in semiarid suburbanizing watersheds: A southern California case study

    Science.gov (United States)

    Hawley, R. J.; Bledsoe, B. P.

    2013-07-01

    Semiarid channels exhibit an extreme sensitivity to upstream urban development, particularly in unconfined valleys with unprotected grades. For example, one of our study streams in southern California has increased its cross-sectional area by nearly 14-fold relative to its pre-developed channel form in a watershed that has been only lightly developed (10.4% imperviousness). Multivariate regression models of cross-sectional channel enlargement at 61 sites were highly dependent on the ratio of post- to pre-urban sediment-transport capacity over cumulative duration simulations of 25 yrs (Lr), which explained nearly 60% of the variance. The proximity of a channel hard point such as bedrock or artificial grade control was also significant, indicating that channel enlargement increased moving upstream from grade control. The enlargement models point to the importance of balancing the post-developed sediment transport to the pre-developed setting over an entire range of flows rather than a single flow in order to reduce the risk of adverse channel responses to hydromodification. The need for controlling a wide range of flows was underscored by logistic-regression analyses that indicated a high risk of instability in systems with Lr > 1, especially for fine-grained systems (i.e., d50 < 16 mm).

  7. Reversible and non-reversible enlargement of cerebral spinal fluid spaces in anorexia nervosa

    Energy Technology Data Exchange (ETDEWEB)

    Artmann, H.; Grau, H.; Adelmann, M.; Schleiffer, R.

    1985-07-01

    Brain CT studies of 35 patients with anoxia nervosa confirmed the observations of other authors: cerebral dystrophic changes correlate with weight loss and the reversibility of these changes also correlates with the normalization of body weight. Other corroborated facts are: the most numerous and most pronounced enlargements are of the cortical sulci and the interhemispheric fissure, moderate widening affects the ventricles and the rarest and most insignificant changes are those of the cerebellum. The reversibility of the changes showed a parallel to the extent of the changes themselves and to the duration of improvement of the body weight. The reversibility of the enlargement of the cortical sulci and of the distances between the frontal horns of the lateral ventricles was more often significant than that of the abnormal measurements of the cella media. This difference is based on minimal early acquired brain damage which occurs in 60% of our patients. This high incidence of early acquired minimal brain disease in patients with anorexia nervosa is here discussed as a nonspecific predisposing factor. Although there is no exact explanation of the etiology of the reversible enlargement of cerenral spinal fluid (CSF) spaces in anorexia nervosa, the changes resemble those in alcoholics. The mechanisms of brain changes in alcoholism, as shown experimentally, seem to us to throw light on the probable mechanism of reversible dystrophic brain changes in anorexia nervosa.

  8. Inhibitory effects by ayurvedic plants on prostate enlargement induced in rats

    Directory of Open Access Journals (Sweden)

    Rahul K Dumbre

    2014-01-01

    Full Text Available Background: Ayurveda recommends several plants and plant preparation for conditions of urogenital disorders as per its principles. Objectives: Ayurvedic plants Tamala (Cinnamomum tamala; Daruhalad (Berberis aristata; Ativish (Aconitum heterophyllum were studied for mechanisms of prostatic hyperplasia induced in rats. Materials and Methods: Prostatic enlargement was induced in castrated rats by testosterone injection s.c. for 21 days and simultaneously plants were dosed orally daily. On day 22 rats were sacrificed and prostate was removed; weight and volume of prostate was measured; histopathology performed. Inflammation was induced by injecting carrageenan in rat hind paw and inhibition was studied by measuring rat paw oedema at different time points. Results: Tamala showed significant effect where it reduced prostatic enlargement and improved hyperplastic changes, while Daruhalad and Ativisha did not show any significant effect. All of them showed mild to moderate anti-inflammatory activity. Conclusion: Study concludes that Tamala may benefit in prostate disorder by virtue of inhibition of androgen mechanisms in prostate and modulating inflammatory mediators in prostate. Daruhalad and Ativisha did not show any effect in this model of prostate enlargement while the anti-inflammatory effect may propose one of the useful properties when included in various formulations.

  9. The Significance of Macrocephaly or Enlarging Head Circumference in Infants With the Triad

    Science.gov (United States)

    Miller, David; Barnes, Patrick; Miller, Marvin

    2015-01-01

    Abstract Infants with the triad (neurologic dysfunction, subdural hematoma [SDH], and retinal hemorrhage) are often diagnosed as victims of shaken baby syndrome. Medical conditions/predisposing factors to developing the triad are often dismissed: short falls, birth-related SDH that enlarges, macrocephaly, sinus/cortical vein thrombosis, and others. Six infants with the triad are described in which child abuse was diagnosed, but parents denied wrongdoing. All 6 had either macrocephaly or enlarging head circumference, which suggested medical explanations. Three infants incurred short falls, 1 had a difficult delivery in which there was likely a rebleed of a birth-related SDH, 1 had a spontaneous SDH associated with increased extra-axial fluid spaces, and 1 had a sinus thrombosis. Following legal proceedings, all 6 infants were returned to their parents, and there has been no child maltreatment in follow-up, suggesting child abuse never happened. The results indicate that alternative medical explanations for causing the triad should be considered and that macrocephaly or an enlarging head circumference raises the possibility of a medical explanation. PMID:25893912

  10. Association between gingivitis and anterior gingival enlargement in subjects undergoing fixed orthodontic treatment

    Directory of Open Access Journals (Sweden)

    Fabricio Batistin Zanatta

    2014-06-01

    Full Text Available OBJECTIVE: The aim of this study was to investigate the association among gingival enlargement (GE, periodontal conditions and socio-demographic characteristics in subjects undergoing fixed orthodontic treatment. METHODS: A sample of 330 patients undergoing fixed orthodontic treatment for at least 6 months were examined by a single calibrated examiner for plaque and gingival indexes, probing pocket depth, clinical attachment loss and gingival enlargement. Socio-economic background, orthodontic treatment duration and use of dental floss were assessed by oral interviews. Associations were assessed by means of unadjusted and adjusted Poisson's regression models. RESULTS: The presence of gingival bleeding (RR 1.01; 95% CI 1.00-1.01 and excess resin around brackets (RR 1.02; 95% CI 1.02-1.03 were associated with an increase in GE. No associations were found between socio-demographic characteristics and GE. CONCLUSION: Proximal anterior gingival bleeding and excess resin around brackets are associated with higher levels of anterior gingival enlargement in subjects under orthodontic treatment.

  11. [Mother and son with enlarged parietal foramina, persistent fetal vein, and ALX4 mutation].

    Science.gov (United States)

    Morita, Motoaki; Nanba, Eiji; Adachi, Kaori; Ohno, Kousaku

    2016-05-01

    Enlarged parietal foramina (EPF) are rare congenital skull defects. These round or oval defects are situated on each parietal bone approximately 1 cm from the midline. Most patients with EPF have a positive family history. The condition is inherited as an autosomal dominant trait with relatively high, but not full, penetrance. Mutation in either MSX2 or ALX4 genes is associated with enlarged parietal foramina. Case 1 is a boy who was noticed to have a large anterior fontanelle, large posterior fontanelle, and widely opened sagittal suture at 2 months. During development, the anterior fontanelle and sagittal suture closed at 3 years and the posterior fontanelle subsequently divided into two foramina with ossification of the midline bridge by 4 years. The foramina were about 2.5 x 2.5 cm in diameter at 8 years. Case 2 is the 34-year-old mother of Case 1. She showed similar bone defects in her cranium, again about 2.5 x 2.5 cm in diameter. Neither patient showed any neurological symptoms. Genetic analysis revealed a mutation in the ALX4 gene in both patients, and magnetic resonance imaging showed a persistent falcine sinus and a hypoplastic straight sinus. Further evaluation revealed that the mother of Case 2 also had a mutation in the ALX4 gene, but no enlarged parietal foramina. Although high penetrance of this condition has been reported, this family suggests incomplete penetrance of this disorder. PMID:27349084

  12. The Eurosafe Forum 2003: Nuclear expertise and challenges of the enlargement of the European Union

    International Nuclear Information System (INIS)

    EUROSAFE is an international forum for discussions among experts from technical safety organisations, research institutes, safety authorities, utilities, the industry, public authorities and non-governmental organisations concerning the status of and recent achievements in nuclear installation safety, waste management, radiation safety and nuclear material security. The Eurosafe Forum 2003 - the fifth of its kind - was held at the Palais Brongniart in Paris on November 25 and 26, 2003. This year's theme was: 'Nuclear expertise and challenges of the enlargement of the European Union: speakers in the various European countries about the environmental scan before enlargement, development and structuring perspectives within the enlarged Europe'. The event brought together 445 experts and researchers from around the world (including 124 from Germany, 184 from France, 88 from Eastern Europe, as well as representatives from Korea, Japan, the United States, Canada, Cuba, and Armenia. The proceedings of the symposium can now be consulted online. The fifth edition of the forum focused on nuclear expertise and the challenge of EU-enlargement and the latest work carried out by GRS, IRSN and their partners from the European Union, Switzerland and Eastern Europe. Nuclear energy contributes approximately one third of European electricity production. A high level of nuclear safety is a priority for the countries of Europe. The technical safety organisations play an important role in contributing to that objective through appropriate approaches to major safety issues as part of their assessments and research activities. The challenges to nuclear safety are increasingly international. Changes in underlying technologies such as instrumentation and control, the impact of electricity market deregulation, demands for improved safety, the ageing of nuclear facilities, waste management, maintaining and improving scientific and technical knowledge and the need for greater transparency

  13. Wellbore enlargement investigation: Potential analogs to the Waste Isolation Pilot Plant during inadvertent intrusion of the repository

    International Nuclear Information System (INIS)

    This study involved the evaluation and documentation of cases in which petroleum wellbores were enlarged beyond the nominal hole diameter as a consequence of erosion during exploratory drilling, particularly as a function of gas flow into the wellbore during blowout conditions. A primary objective was to identify analogs to potential wellbore enlargement at the Waste Isolation Pilot Plant (WIPP) during inadvertent human intrusion. Secondary objectives were to identify drilling scenarios associated with enlargement, determine the physical extent of enlargement, and establish the physical properties of the formation in which the enlargement occurred. No analogs of sufficient quality to establish quantitative limits on wellbore enlargement at the WIPP disposal system were identified. However, some information was obtained regarding the frequency of petroleum well blowouts and the likelihood that such blowouts would bridge downhole, self-limiting the surface release of disposal-system material. Further work would be necessary, however, to determine the conditions under which bridging could occur and the extent to which the bridging might be applicable to WIPP. In addition, data on casing sizes of petroleum boreholes in the WIPP vicinity support the use of a 12-1/4 inch borehole size in WIPP performance assessment calculations. Finally, although data are limited, there was no evidence of significant wellbore enlargement in any of three blowouts that occur-red in wellbores in the Delaware Basin (South Culebra Bluff Unit No. 1, Energy Research and Development Administration (ERDA) 6, and WIPP 12)

  14. Transient enlargement of contrast uptake on MRI after linear accelerator (linac) stereotactic radiosurgery for brain metastases

    International Nuclear Information System (INIS)

    Purpose/Objective: With the increasing number of patients successfully treated with stereotactic radiosurgery for brain metastases, decision making after therapy based on follow-up imaging findings becomes more and more important. Magnetic resonance imaging (MRI) is the most sensitive means for follow-up studies. The objective of this study was to investigate the treatment outcome of our radiosurgery program and to describe the response of brain metastases to contrast-enhanced MRI after linear accelerator (linac) stereotactic radiosurgery and identify factors to distinguish among local control and local failure. Methods and Materials: Using serial MRI, we followed the course of 87 brain metastases in 48 consecutive patients treated between September 1996 and November 1997 with linac-based radiosurgery with 15-MV photons. Treatment planning was performed on an MR data cube. For spherical metastases, radiosurgery was delivered using a 9 noncoplanar arc technique with circular-shaped collimators. For irregularly shaped targets, radiosurgery was delivered using a manually driven multi-leaf collimator with a leaf width of 1.5 mm projected to the isocenter. Median radiosurgery dose was 20 Gy prescribed to the 80% isodose. Together with whole brain radiotherapy (20x2 Gy, 5/w), a median radiosurgical dose of 15 Gy was delivered. Median follow-up was 8 (range 2-36) months. Factors influencing local control and survival rates were analyzed with respect to MRI response, and Kaplan-Meier curves were calculated. Results: Actuarial local tumor control was 91% at one and two years. Patient survival at one and two years was 30% and 18%. Median survival was 9 months. During follow-up in 70 (81%) of the 87 treated metastases, the contrast-enhancing volumes on T1W images were stable or disappeared partly or completely. A transient enlargement of contrast-enhancing volumes was observed in 11 (12%) of the 87 lesions treated, while a progressive enlargement due to local treatment

  15. The detailed somatotopic organization of the dorsal horn in the lumbosacral enlargement of the cat spinal cord.

    Science.gov (United States)

    Wilson, P; Meyers, D E; Snow, P J

    1986-03-01

    The somatotopic organization of spinocervical tract cells and unidentified dorsal horn neurons that lie in the same depth range as the spinocervical tract cells has been examined in detail in the lumbosacral enlargement of cats anesthetized with alpha-chloralose. Only gentle hair movement or light touch of glabrous skin were used as stimuli. Within the region of the dorsal horn containing these neurons there is a precise somatotopic organization. However, there is considerable variation between animals in the relationship between the somatotopic map and the lumbosacral segmental boundaries. The somatotopic map described here is considered to be restricted to a 300- to 500-micron thick lamina. In the medial half to two-thirds of this lamina in the L6 and L7 segments the toes are represented in a rostrocaudal sequence from toe 2 to toe 5. Over the most medial 200-500 micron of this part of the dorsal horn are found cells that respond to stimulation of the glabrous skin of the toe pads and the central pad. The toe representation is surrounded by a strip of foot representation, which is in turn surrounded by a strip of leg representation. The most lateral part of the lamina curves ventrally in the L6 and L7 segments and contains a continuous rostrocaudal representation of the skin of the thigh. In this region are found both spinocervical tract cells and unidentified dorsal horn neurons with receptive fields on the thigh. The skin of the hindlimb is represented such that a line of discontinuity runs down the posteromedial thigh, leg, and foot. Skin lateral to this line is represented caudally, while skin medial to it is represented rostrally. PMID:3958785

  16. Determination of nanomolar uric and ascorbic acids using enlarged gold nanoparticles modified electrode.

    Science.gov (United States)

    Kannan, P; John, S Abraham

    2009-03-01

    Individual and simultaneous determination of 50nM uric acid (UA) and ascorbic acid (AA) using enlarged, citrate-stabilized gold nanoparticles (AuNPs) self-assembled to 2,5-dimercapto-1,3,4-thiadiazole (DMT) monolayer modified Au (Au/DMT) electrode by an amperometric method is described for the first time. Self-assembly of AuNPs on the electrode surface was confirmed by atomic force microscopy (AFM), attenuated total reflectance FT-IR and diffuse reflectance spectral measurements. The electron transfer reaction (ETR) of [Fe(CN)(6)](3-/4-) was blocked at Au/DMT electrode, whereas it was restored with a peak separation of 200mV after the attachment of AuNPs on the Au/DMT (Au/DMT/AuNPs) electrode, which was confirmed from the ETR of the [Fe(CN)(6)](3-/4-) redox couple. When the self-assembled AuNPs were enlarged by hydroxylamine seeding, the ETR of [Fe(CN)(6)](3-/4-) was improved significantly with a peak separation of 100mV. Tapping mode AFM showed that the average size of the enlarged-AuNPs (E-AuNPs) was 50-70nm. The E-AuNPs modified electrode catalyzes the oxidation of AA and UA, separates their voltammetric signals by 200mV, and has excellent sensitivity towards AA and UA with a detection limit of 50nM. The practical application of the modified electrode was demonstrated by measuring the concentration of UA in blood serum and urine. PMID:19111516

  17. Communities, Boundaries and New Neighbours: the Discursive Construction of EU Enlargement

    Directory of Open Access Journals (Sweden)

    Giuditta Caliendo

    2008-12-01

    Full Text Available The institutional discourse of the European Union (EU is undergoing important changes that are also reflected by new initiatives in its communication policy. Against a background of widespread scepticism towards EU enlargement among the public, this change is driven by the need to promote the widening of its borders in a more effective way in order to prompt popular endorsement. Through the use of its textual and visual communicative strategies, the EU is thus finding new ways to buttress its legitimacy and raise consensus around its political actions. The node of interaction between citizens and institutions is represented by the informative publications of the EU (also made available on the europa website, which become a constitutive element in building Union-to-citizen communication. The analysis of textual and visual formulations of the European Commission’s key booklets on EU enlargement in the period from 2004 to 2007 - in terms of their content and pragmatic aims - reveals the emergence of new consensus-building strategies. Results show that a sense of allegiance and belonging attributed to a deepening of European integration is now increasingly linked to the practical advantages of EU enlargement, as expressed through the use of ‘promotional’ and strategic discursive practices. Moving away from a merely informative content, communication modes ‘migrate’ towards a more direct and ‘commodified’ type of message, while an increase in visual elements plays a complementing role in promoting legitimacy and a feeling of mutual belonging between ‘old’ and ‘new’ members of the European family.

  18. Unusual looping of the internal carotid artery in relation to an enlarged lymph node

    Directory of Open Access Journals (Sweden)

    Nayak SB

    2010-06-01

    Full Text Available Knowledge of variations of internal carotid artery is important to surgeons doing head and neck surgery as well as to radiologists doing imaging and invasive techniques. In the current case, the right internal carotid artery showed a characteristic loop at its beginning. An abnormal, enlarged lymph node was found at the carotid bifurcation, which was projecting into the loop. The left internal carotid artery was normal. The unusual looping of internal carotid artery at its beginning might result in altered blood flow to the brain and may lead to confusions in surgical, imaging and invasive techniques.

  19. Imaging diagnosis of enlarged uterus; Comparison of ultrasonography and MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Harada, Mikihiko; Yamashita, Yasuyuki; Sawada, Takamine; Takahashi, Mutsumasa; Aragane, Futoshi; Miyazaki, Koji; Okamura, Hitoshi (Kumamoto Univ. (Japan). School of Medicine)

    1992-02-01

    We evaluated ultrasonographic and MRI findings of 24 histologically proven cases of enlarged uterus, which consisted of 19 cases of myoma uteri and 7 cases of adenomyosis. Preoperative diagnostic accuracy was 70% for ultrasonography , and 96% for MR imaging. In this retrospective study comparing with macroscopic specimens, there was no significant difference between myoma uteri and adenomyosis on sonographic appearances, while significant differences were observed on MRI in regard to the margin of the lesions, myometrial contour, and presence of internal high intensity spots. Furthermore, MR imaging reflected macroscopic appearance of specimens more accurately. However, there were some diagnostic pitfalls even on MR imaging. (author).

  20. Future of nuclear energy in the enlarged European Union: a perspective from Brussels

    International Nuclear Information System (INIS)

    As a trade association of the European nuclear industry FORATOM works to enhance the relations between the industry and European institutions, provides information on nuclear energy to the European institutions, considers the EU enlargement process as the top priority in the lobbying actions. FORATOM working groups focus on the following subjects: accession, climate change, legal affairs, nuclear research and development, decommissioning, quality management, waste, transport, security of supply and sustainable development. The paper presents the current activities and future tasks in the EUs changing operational environment

  1. 10 Years After: EU Enlargement, Closed Borders, and Migration to Germany

    OpenAIRE

    Elsner, Benjamin; Zimmermann, Klaus F.

    2013-01-01

    We study how the EU enlargement in 2004 and the Great Recession in the late 2000s have shaped the scale and composition of migration flows from the New Member States to Germany. We demonstrate that immigration increased substantially despite the restrictions on the German labor market, and that net flows decreased to zero at the outset of the recession. The cohorts arriving after 2004 had on average a lower education than the previous arrival cohort, but the wage gap compared to Germans becam...

  2. Innovation, market structure, and competition policy in the Czech Republic and in the Enlarged EU

    Czech Academy of Sciences Publication Activity Database

    Zemplinerová, Alena

    Leipzig: Leipziger Universitätsverlag, 2009 - (Kunze, C.; Lenk, T.), s. 89-98. (Transformation: Leipziger Beiträge zu Wirtschaft und Gesellschaft. 25). ISBN 978-3-86583-102-6. ISSN 0947-0379. [Innovation as a key factor of economic growth in the enlarged European Union. Leipzig (DE), 20.11.2008-21.11.2008] R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : competition * innovation * market structure * research and development Subject RIV: AH - Economics

  3. Use of minocycline as systemic antimicrobial therapy in refractory periodontitis with chronic gingival enlargement

    Directory of Open Access Journals (Sweden)

    Parag M Khatri

    2012-01-01

    Full Text Available Periodontal disease is a multifactorial disease having various risk factors, but a dynamic interaction between bacterial products and host response in association with genetic and environmental factors is considered as the primary cause for periodontal tissue destruction in periodontitis. This bacterial-host interaction which is ever-so-present in periodontitis directs us toward utilizing antimicrobial agents along with the routine mechanical debridement. This case report present a case of a female patient with recurrent periodontal infections with gingival enlargement treated with systemic Minocycline in conjunction with the conventional non-surgical approach.

  4. Engrosamiento peneano: complicación de lipotransferencia Penis enlargement: complication of lipotransfer

    OpenAIRE

    C.G. Conde; J.H. Soria; O.D. Orduna; E. Alcoba

    2012-01-01

    La solicitud de engrosamiento del pene por parte de los pacientes tiene un crecimiento sostenido. El empleo de grasa autóloga como relleno puede causar una deformidad que provoca un menoscabo funcional y estético. Presentamos un caso de complicación que requirió de tratamiento quirúrgico.Penis enlargement is a practice widely requested by the patients. The use of autologous fat transplantation can produce deformity and functional and aesthetic deficiency. The authors present a clinical case o...

  5. SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct

    OpenAIRE

    Ito, Taku; Muskett, Julie; Chattaraj, Parna; Choi, Byung Yoon; Lee, Kyu Yup; Zalewski, Christopher K.; King, Kelly A.; Li, Xiangming; Wangemann, Philine; Shawker, Thomas; Brewer, Carmen C.; Alper, Seth L.; Griffith, Andrew J

    2013-01-01

    Pendred syndrome (PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct (EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PS or SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in ¼ of North American or European EVA populations, one mutant allele is detected in another ¼ of patient populations, and no mutations are detected in the other ½....

  6. Serial MR imaging studies in enlarged endolymphatic duct and sac syndrome

    International Nuclear Information System (INIS)

    Large vestibular aqueduct syndrome (LVAS) is a congenital disorder characterized by progressive or fluctuating sensorineural hearing loss of unknown etiology. Serial MR examinations were performed before and after the development of hearing loss in two patients with LVAS. The signal and volume of the enlarged endolymphatic sac (EES) vary even in ears with stable hearing. In ears with fluctuating hearing, changes in EES signals were observed in only one of two patients. The finding that the EES volume and signal intensity vary dynamically independently of hearing is important for future research into the pathophysiology of hearing loss in this syndrome. (orig.)

  7. International marketing in an enlarged European Union: Some insights into cultural heterogeneity in Central Europe

    OpenAIRE

    Skinner, Heather; Kubacki, Krzysztof; Moss, Gloria; Chelly, David

    2008-01-01

    We inhabit a global village in which international marketers are encouraged to think and act with both global and local interests in mind. The enlargement of the European Union (EU) in January 2007 has created a 27 member state EU with a population of nearly half a billion. The purpose of this article is therefore to examine the nature of these differences in so far as they impact on the segmentation decisions made by international marketers. This article examines the literature on culture, i...

  8. The effect of the 2004 and 2007 EU enlargement on the Spanish labour market

    OpenAIRE

    de la Rica, Sara.

    2009-01-01

    The 2004 and 2007 EU enlargement has led to a significant increase in the immigration flow to Spain. Individuals from the new-EU-12 countries accounted for no more than 10% of the whole Spanish immigrant population in 2004, but by 2008 they accounted for almost 20% of the total flow of immigrants. As of 2008, immigrants from Bulgaria, Poland and Rumania account for 97 percent of new-EU-12 immigrants. These immigrants are younger, and the vast majority of them are educated to secondary level. ...

  9. Enlargement of filtration and predictable representation property for semi-martingales

    OpenAIRE

    Calzolari, Antonella; Torti, Barbara

    2013-01-01

    We present two examples of loss of the predictable representation property for semi-martingales by enlargement of the reference filtration. First of all we show that the predictable representation property for a square-integrable semi-martingale X does not transfer from the reference filtration F to a larger filtration G when the information starts growing up to a positive time. Then we study the case when F coincides with the natural filtration of X and G is obtained by adding the natural fi...

  10. Enlarged Right Atrium Falsely Interpreted as a Mediastinal Mass: A Case Report

    Directory of Open Access Journals (Sweden)

    Farid Zand

    2015-09-01

    Full Text Available Right atrial dilation due to left heart disease is a common complication among adults. The present review aimed to describe a case of massively dilated right atrium in a female patient presenting with valvular heart disease and no atrial fibrillation. The results of chest X-ray revealed a large opacity filling the lower right hemithorax, falsely interpreted as a mediastinal mass. During the transesophageal echocardiography, severe enlargement of the right atrium was detected, and open mitral and tricuspid valve replacements were performed successfully.

  11. Dual Enlargement of Gold Nanoparticles: From Mechanism to Scanometric Detection of Pathogenic Bacteria

    DEFF Research Database (Denmark)

    Cao, Cuong; Gontard, Lionel Cervera; Le Ly, Tram Thuy;

    2011-01-01

    electron density of the nanostructures, leading to a stronger intensity for colorimetric discrimination as well as better sensitivity for quantitative measurement. Based on this, a simple scanometric assay for the on‐slide detection of the food‐born pathogen Campylobacter jejuni is developed. After...... capturing the target bacteria, gold‐tagged immunoprobes are added to create a signal on a solid substrate. The signal is then amplified by the dual enlargement process, resulting in a strong color intensity that can easily be recognized by the unaided eye, or measured by an inexpensive flatbed scanner. In...

  12. Efficient Molecular Genetic Diagnosis of Enlarged Vestibular Aqueducts in East Asians

    OpenAIRE

    Choi, Byung Yoon; Stewart, Andrew K.; Nishimura, Katherine K.; Cha, Won Jae; Seong, Moon-Woo; Park, Sung Sup; Kim, Seung Won; Chun, Yang Sook; Chung, Jong Woo; Park, Shi-Nae; Chang, Sun O; Kim, Chong-Sun; Alper, Seth L; Griffith, Andrew J.; Oh, Seung-Ha

    2009-01-01

    Context: Enlargement of the vestibular aqueduct (EVA) is a commonly detected inner ear anomaly related to hearing loss and often associated with mutations of SLC26A4 encoding pendrin, a transmembrane exchanger of Cl−, I−, and HCO3−. Here we describe the phenotypes of 27 Korean EVA subjects and their SLC26A4 genotypes determined by bidirectional nucleotide sequencing. Results: The detected variants include two novel missense substitutions (p.V138L and p.P542R). We characterized the ability of ...

  13. Successful nonsurgical management of post-orthodontic gingival enlargement with intensive cause-related periodontal therapy.

    Science.gov (United States)

    Kwon, TaeHyun; Kim, David M; Levin, Liran

    2015-03-01

    Successful nonsurgical management of severe postorthodontic gingival enlargement and erythema in a 24-year-old male is presented. The patient received an intensive cause-related periodontal therapy, consisting of oral hygiene instruction, scaling and root planing, and weekly recall visits. At week five, complete resolution of the lesions was achieved. By targeting the primary etiologic factor, i.e., plaque, periodontal health was restored without needing surgical intervention. Reducing the bacterial load will give the biologic natural healing capacity of the body the opportunity to stabilize the periodontal condition and, thus, should be considered as the first line of intervention before a surgical approach is taken. PMID:25928969

  14. To enlarge the travel markets from Shanghai to Turku (Shanghai CITS, Ltd.)

    OpenAIRE

    Wang, Chunyang

    2010-01-01

    This paper is made in order to make thorough analysis in current Chinese travel markets and travel agencies, as well as the analysis on Turku’s travel markets, with which it can know the feasibility in enlarge the travel markets for CITS into Turku. In details, as the background information, the brief overview of history of China’s domestic travel agencies and a brief description of Shanghai CITS in terms of its business and management status are posed with the aim of getting enough suppo...

  15. U.S. decisionmaking process on NATO enlargement: implications for East Eurpoean States

    OpenAIRE

    Malashchenko, Vitaliy B.

    1996-01-01

    This thesis examines the evolution of post-Cold War U.S. policy towards NATO as a case study of the way in which domestic and international pressures interact to shape security policy. I argue that the expansion of U.S. commitments to post-Cold War Europe corresponds to the way key U.S. policymaking institutions have framed American national interests. President Clinton, his key advisers and Republican leaders of Congress emphasize that NATO enlargement advances American interests by accelera...

  16. An enlarged postcranial sample confirms Australopithecus afarensis dimorphism was similar to modern humans.

    Science.gov (United States)

    Reno, Philip L; McCollum, Melanie A; Meindl, Richard S; Lovejoy, C Owen

    2010-10-27

    In a previous study, we introduced the template method as a means of enlarging the Australopithecus afarensis postcranial sample to more accurately estimate its skeletal dimorphism. Results indicated dimorphism to be largely comparable to that of Homo sapiens. Some have since argued that our results were biased by artificial homogeneity in our Au. afarensis sample. Here we report the results from inclusion of 12 additional, newly reported, specimens. The results are consistent with those of our original study and with the hypothesis that early hominid demographic success derived from a reproductive strategy involving male provisioning of pair-bonded females. PMID:20855309

  17. Enlargement of the band gaps of water waves over one-dimensional combination bottom structures

    International Nuclear Information System (INIS)

    The phenomena of band gaps and propagation of water waves over one-dimensional periodic bottoms and combination bottoms is investigated by the transfer matrix method. For the periodic bottoms (PBs), the effect of the steps' numbers, their height and width on the band gaps are discussed, respectively. For two kinds of combination periodic-bottoms (CPBs), namely height-CPBs and width-CPBs, both corresponding whole band gaps are gained, respectively. Each of whole band gaps is the juxtaposition of the gaps of two kind of PBs, without covering. The numerical results show that the band gaps could be enlarged effectively by choosing the steps' height or width properly

  18. Spatial bandwidth enlargement and field enhancement of shear horizontal waves in finite graded piezoelectric layered media

    KAUST Repository

    Xu, Yanlong

    2015-09-01

    Shear horizontal (SH) wave propagation in finite graded piezoelectric layered media is investigated by transfer matrix method. Different from the previous studies on SH wave propagation in completely periodic layered media, calculations on band structure and transmission in this paper show that the graded layered media possess very large band gaps. Harmonic wave simulation by finite element method (FEM) confirms that the reason of bandwidth enlargement is that waves within the band gap ranges are spatially enhanced and stopped by the corresponding graded units. The study suggests that the graded structure possesses the property of manipulating elastic waves spatially, which shows potential applications in strengthening energy trapping and harvesting. © 2015.

  19. Engrosamiento peneano: complicación de lipotransferencia Penis enlargement: complication of lipotransfer

    Directory of Open Access Journals (Sweden)

    C.G. Conde

    2012-12-01

    Full Text Available La solicitud de engrosamiento del pene por parte de los pacientes tiene un crecimiento sostenido. El empleo de grasa autóloga como relleno puede causar una deformidad que provoca un menoscabo funcional y estético. Presentamos un caso de complicación que requirió de tratamiento quirúrgico.Penis enlargement is a practice widely requested by the patients. The use of autologous fat transplantation can produce deformity and functional and aesthetic deficiency. The authors present a clinical case of complication and its surgical resolution.

  20. The Deadlock that never Happened: the Impact of Enlargement on the Common Foreign and Security Policy Council Working Groups

    OpenAIRE

    JUNCOS, Ana E; Karolina Pomorska

    2007-01-01

    Contrary to some previous assumptions, the enlargement did not halt the Common Foreign and Security Policy (CFSP) decision-making process in a substantial way. Rather it changed the dynamics within the working environment, preserving the importance of consensus-building practices in the Council working groups. The aim of this article is twofold. First, it tracks the changes that the recent enlargement caused in the working practices of the Council working groups. It also attempts to assess th...

  1. 'Bringing Geopolitics Back In': Exploring the Security Dimension of the 2004 Eastern Enlargement of the European Union

    OpenAIRE

    O'Brennan, John

    2006-01-01

    Notwithstanding the functional and technocratic basis of the European integration process, and the fact that the accession criteria hardly mention security issues, the 2004 eastern enlargement brought to the forefront of EU politics important geopolitical and security issues. Eastern enlargement came on to the agenda of the EU in the wake of 1989s peaceful revolutions in Central and Eastern Europe. Security and geopolitics mattered to the decision taken by the EU to embark on expansion in the...

  2. Right heart enlargement in heartworm-infected dogs: a radiographic, electrocardiographic, and echocardiographic correlation

    International Nuclear Information System (INIS)

    Radiographically, the size of the right ventricle of 54 heartworm-infected dogs was graded subjectively as normal, 1 +, 2 +, and 3 + and served to classify the dogs into groups A, B, C, and D. With M-mode echocardiograms, right ventricular enlargement ratios (RVE ratios) were determined for each dog by dividing the measured right ventricular internal diastolic dimension (RVIDd) by the expected RVIDd of a normal dog of the same body weight. The normal RVIDd relation to body weight was derived from 25 healthy heartworm-free control dogs. These two variables were linearly related with a correlation coefficient r2 = 0.59. Means and standard deviations of the RVE ratio were calculated for each group. Despite wide ranges and considerable overlap, the ratio was significantly different (t-test, p < 0.005) between groups with the exception of groups A and B, and C and D. The incidence of electrocardiographic signs of right ventricular hypertrophy was also determined for each group; it was 38% in group C and 62% in group D. From this data, it was concluded that M-mode echocardiography is a very sensitive technique for the documentation of right ventricular dilatation in heartworm-infected dogs, correlating with radiographic impressions of right ventricular enlargement. (author)

  3. Improvement on Diversity Gain with Filter Bandwidth Enlargement in Fractional Sampling OFDM Receiver

    Science.gov (United States)

    Shinkai, Toshiya; Nishimura, Haruki; Sanada, Yukitoshi

    A diversity scheme with Fractional Sampling (FS) in an OFDM receiver has been investigated recently. Through FS, it is possible to separate multipath components and obtain diversity gain in OFDM systems. Enlargement of the bandwidth of the total frequency response between transmit and receive baseband filters allows the FS scheme to achieve path diversity. However, the transmit filter has to be designed according to the spectrum mask of the wireless standards such as IEEE802.11a/g to avoid interference to the other communication systems and the frequency response of the composite channel including the transmit and receive filters has often been set to minimal bandwidth to eliminate adjacent channel signals. In order to achieve the maximum signal-to-noise ratio (SNR), the same filter is commonly used in the transmitter and the receiver. In this paper, the trade-off among the SNR deterioration, adjacent channel interference, and the diversity gain due to the enlargement of the bandwidth of the receive filter is investigated. Numerical results from computer simulations indicate that the BER performance with wider bandwidth in the receiver shows better performance than that with the minimal bandwidth for maximizing the SNR in certain conditions.

  4. Multivariate analysis of morphological pathology in ventricular enlargement by computed tomography

    International Nuclear Information System (INIS)

    Several ventricular segments were first measured linearly on the CT image to determine the normal upper limit in adolescent and mature subjects. On the basis of the values obtained, large ventricules were defined, and discriminant analysis with the increase and decrease of the variable was applied. The error ratio of discrimination between pressure hydrocephalus and cerebral atrophy was 8.4%. The temporal horn and trigone are larger in pressure hydrocephalus than in cerebral atrophy, in which the anterior horn is larger. The error ratio of discrimination between obstructive hydrocephalus and communicating hydrocephalus was 11.3%. The hypothalamic segment of the third ventricle and the body of the lateral ventricle are larger in obstructive hydrocephalus than in communicating hydrocephalus, in which the anterior horn and the cellae mediae at the level of the head of caudate nuclei are relatively large. Enlarged ventricles were divided into three groups with characteristic segment: one with large temporal horn and trigone in pressure hydrocephalus; one with larger hypothalamic segment of the third ventricle and larger body of the lateral ventricle in obstructive hydrocephalus than in communicating hydrocephalus; and relatively large anterior horn, cellae mediae at the level of the head of caudate nuclei, and thalamic segment of the third ventricle in cerebral atrophy and communicating hydrocephalus. These findings contribute to the pathological evaluation of ventricular enlargement. The hypothalamic segment of the third ventricle assumes a round or oval shape in pressure hydrocephalus but a rectangular or teardrop shape in cerebral atrophy. (J.P.N.)

  5. CONNECTING THE ENLARGEMENT PROCESS WITH THE EUROPEANIZATION THEORY (THE CASE OF TURKEY

    Directory of Open Access Journals (Sweden)

    Teodor Lucian Moga

    2010-03-01

    Full Text Available Europeanization is one of the theoretical instruments which had a vital influence on candidate countries for EU membership. Due to its aspirations of becoming member of the European Union (EU and in its attempt to fulfil the Copenhagen criteria, Turkey is trying to comply with the EU acquis communautaire. The aim of this paper is to assess the effects of the Europeanization process on the countries subject to EU enlargement strategy, with a special focus on Turkey, particularly since the country received the EU candidate status in 1999. This paper has been organized in the following way: firstly, it points out how both the traditional Europeanization and the enlargement led Europeanization have been depicted in the work of several important scholars; secondly, by offering a short overview of Turkey’s foreign relations vis-à-vis its neighbourhood, especially in the last decade, it examines how the mechanism of Europeanization largely influenced the country’s diplomatic culture. Traditionally, Turkey has been attuned to hard security issues and architectures. However, the Turkish foreign policy strategy emphasised in thepast years the Venus side of things in many settings in line with EU requirements.

  6. The enlargement of the European Union. Effects on trade and emissions of greenhouse gases

    International Nuclear Information System (INIS)

    With the gradual accession of various Central and Eastern European Countries (CEECs) to the European Union (EU), international trade between the EU and the CEECs will change as a result of trade liberalisation and the mobility of production factors within the EU. The EU and most of the CEECs have already committed themselves to reduce by 2008-2012 their emissions of greenhouse gases (GHGs) by 8% compared to the 1990 level. This paper reports on an investigation of the potential consequences of the enlargement of the EU and of the emission reduction target set by the Kyoto Protocol on the sectoral production patterns and international trade. A comparative-static general equilibrium model was developed to examine the impacts under different scenarios. For illustrative purposes, two regions (the EU and the CEECs) and three categories of goods and services (agricultural goods, industrial goods, and services) were included. The model was calibrated by the 1998 data. The model was subsequently applied to study the effects of free trade, the mobility of factors and the environmental constraints on production and international trade in light of the enlargement of the EU. We show that in this specific context, free trade is beneficial to economic welfare and does not necessarily increase emissions of greenhouse gases. The mobility of factors also increases economic welfare, but in the case of fixed production technology it may harm the environment through more emissions of GHGs. (author)

  7. An enlarged intramuscular venous malformation in the femoral region successfully treated with complete resection

    Science.gov (United States)

    Murakami, Takuo; Ogata, Dai; Miyano, Kyohei; Tsuchida, Tetsuya

    2016-01-01

    Introduction Intramuscular venous malformations have been previously described as intramuscular hemangiomas, and various therapies have been applied for their treatment. This condition is relatively rare, and therefore, physicians often struggle to determine the appropriate therapy. We presented a case of an enlarged intramuscular venous malformation relapsed after surgery successfully treated with complete resection. Presentation of case We presented a case of an enlarged intramuscular venous malformation with postoperative recurrence successfully treated with complete resection. A 63-year-old woman presented with a subcutaneous mass in the right distal thigh. She experienced swelling in the right thigh 19 years previously and was diagnosed with a venous aneurysm. Three-dimensional CT angiography confirmed the presence of an irregular vessel assumed to be the feeding vessel, which was dendritically branched from the deep femoral artery. We performed surgical complete resection. Her pain and gait disturbance improved after surgery, and she has not experienced recurrence of the mass for the past 2 years. Discussion Conservative therapy is initially used for venous malformations. Sclerotherapy, laser therapy, or surgical resection is considered after low-dose aspirin therapy, in combination with the use of compressive garments. Surgical resection is indicated for completely resectable lesions and is appropriate for large lesions in terms of cosmetic benefit. However, partial resection may result in excessive bleeding or postoperative recurrence. Conclusion The therapy for venous malformations should be decided based on the degree of disability in daily living, adjacent tissue damage, and cosmetic concerns after appropriate differential diagnostic investigations and biopsy. PMID:26945489

  8. Alice is not missing wonderland the eastward enlargement of the European Union

    Directory of Open Access Journals (Sweden)

    Prokopijević Miroslav

    2005-01-01

    Full Text Available In this paper I will try to show that the EU enlargement from 2004 is not a good economic move for eight newcomers from Central and Eastern Europe (CEECs. It is unlikely that newcomers will get larger FDI, speed up their economic growth and catch up with richer EU countries, although this was broadly advertised both academically and by the EU "propaganda for happiness." The EU subsidies, intended to offset accession costs, turn out to be useless if not damaging for acceding economies, because they change the structure of incentives. So, instead of being rewarded for accession accession countries are going to be punished twice. Firstly, by lower FDI and a persisting GDP gap. Secondly, by getting subsidies which worsen the situation. CEECs would be better off staying outside the EU and continuing to improve economic freedom and the rule of law. But even after they have acceded, there is still some space for reasonable objectives of the CEECs due to unintended consequences of the socialist enlargement design.

  9. The Eurosafe Forum 2003: Nuclear expertise and challenges of the enlargement of the European Union

    Energy Technology Data Exchange (ETDEWEB)

    Lacronique, Jean-Francois; Repussard, Jacques (eds.) [Institut de Radioprotection et de Surete Nucleaire, IRSN, B.P. 17, F - 92262 Fontenay-aux-Roses Cedex (France); Hahn, Lothar (ed.) [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH, GRS, Schwertnergasse 1, D - 50667 Koeln (Germany)

    2003-07-01

    EUROSAFE is an international forum for discussions among experts from technical safety organisations, research institutes, safety authorities, utilities, the industry, public authorities and non-governmental organisations concerning the status of and recent achievements in nuclear installation safety, waste management, radiation safety and nuclear material security. The Eurosafe Forum 2003 - the fifth of its kind - was held at the Palais Brongniart in Paris on November 25 and 26, 2003. This year's theme was: 'Nuclear expertise and challenges of the enlargement of the European Union: speakers in the various European countries about the environmental scan before enlargement, development and structuring perspectives within the enlarged Europe'. The event brought together 445 experts and researchers from around the world (including 124 from Germany, 184 from France, 88 from Eastern Europe, as well as representatives from Korea, Japan, the United States, Canada, Cuba, and Armenia. The proceedings of the symposium can now be consulted online. The fifth edition of the forum focused on nuclear expertise and the challenge of EU-enlargement and the latest work carried out by GRS, IRSN and their partners from the European Union, Switzerland and Eastern Europe. Nuclear energy contributes approximately one third of European electricity production. A high level of nuclear safety is a priority for the countries of Europe. The technical safety organisations play an important role in contributing to that objective through appropriate approaches to major safety issues as part of their assessments and research activities. The challenges to nuclear safety are increasingly international. Changes in underlying technologies such as instrumentation and control, the impact of electricity market deregulation, demands for improved safety, the ageing of nuclear facilities, waste management, maintaining and improving scientific and technical knowledge and the need for greater

  10. Ovarian Germ Cell Tumors Treatment

    Science.gov (United States)

    ... c) cancer cells are found in the pelvic peritoneum. In stage I , cancer is found in one ... in the abdomen ) or in washings of the peritoneum ( tissue lining the peritoneal cavity). Stage II Enlarge ...

  11. The perspectives of energy production from coal-fired power plants in an enlarged EU

    International Nuclear Information System (INIS)

    The aim of this paper is to present the current status of the coal-fired power sector in an enlarged EU (EU-15 plus EU member candidate states) in relation with the main topics of the European Strategy for the energy production and supply. It is estimated that 731 thermoelectric units, larger than 100 MWe, are operating nowadays, and their total installed capacity equals to 200.7 GWe. Coal contribution to the total electricity generation with reference to other fuel sources, is far more intensive in the non-EU part (EU member candidate states), compared to the EU member states. It is expected that even after the enlargement, the European Union will strongly relate to coal. Enlargement will bring additional factors into play in order to meet the requirements of rising consumption, growing demand for conventional fuels and increasing dependence on imports. Besides the technology, boiler size, efficiency, age and environmental performance will determine the necessities of the coal-fired power sector in each country. Depending on the case, lifetime extension measures in operating coal-fired power plants or clean coal technologies can play an important role towards the energy sector restructuring. Low efficiency values in the non-EU coal-fired units and heavily aged power plants in EU countries will certainly affect decisions in favour of upgrading or reconstruction. The overall increase of efficiency, the reduction of harmful emissions from generating processes and the co-combustion of coal with biomass and wastes for generating purposes indicate that coal can be cleaner and more efficient. Additionally, plenty of rehabilitation projects based on CCT applications, have already been carried out or are under progress in the EU energy sector. The proclamations of the countries' energy policies in the coming decades, includes integrated renovation concepts of the coal-fired power sector. Further to the natural gas penetration in the electricity generation and CO2

  12. Enlarging the operation range of a centrifugal compressor by cutting vanes based on CFD

    International Nuclear Information System (INIS)

    Many centrifugal compressors are liable to insufficient operation range. The purpose of this paper is to enlarge the operation range of a centrifugal compressor used in turbocharger by cutting vanes. Some numerical works have been done based on CFD. The comparison of the calculated and measured results shows good agreement. The overall performance characteristics of the centrifugal compressor with different cutted vanes are observed and analyzed. The performance characteristic curves show that cutting vanes can increase the operation range by more than 50% with the loss of the highest efficiency limited in 1%. The flow fields are also shown in this paper and related explanations about the change of the performance characteristics curves are given. Shock wave is also detected in the simulation, and some related characteristics are summed up

  13. Enlarging the operation range of a centrifugal compressor by cutting vanes based on CFD

    Science.gov (United States)

    Mo, J. T.; Gu, C. H.; Pan, X. H.; Y Zheng, S.

    2013-12-01

    Many centrifugal compressors are liable to insufficient operation range. The purpose of this paper is to enlarge the operation range of a centrifugal compressor used in turbocharger by cutting vanes. Some numerical works have been done based on CFD. The comparison of the calculated and measured results shows good agreement. The overall performance characteristics of the centrifugal compressor with different cutted vanes are observed and analyzed. The performance characteristic curves show that cutting vanes can increase the operation range by more than 50% with the loss of the highest efficiency limited in 1%. The flow fields are also shown in this paper and related explanations about the change of the performance characteristics curves are given. Shock wave is also detected in the simulation, and some related characteristics are summed up.

  14. The “transforming power” of EU Enlargement policy in Serbia. An anthropological reflection

    Directory of Open Access Journals (Sweden)

    Francesco Florindi

    2012-05-01

    Full Text Available The enlargement process of the European Union contributed substantially to the harmonisation of legal systems over the continent. The article provides an anthropological critique to the way harmonisation to EU law is implemented in the Balkans, underlining the general lack of awareness by both Serbian government and the EU of Serbian social and legal systems. While applying the anthropological method to EU law’s effects in Serbia, the author investigates also the inner value of the EU project itself. For instance the State's failure to regulate anti-corruption matters has been experienced even when the State's provision in question were in full compliance with several other international obligations and with a positively hierarchically superior legal system: the Constitution.

  15. Micro-CT analyses of apical enlargement and molar root canal complexity

    DEFF Research Database (Denmark)

    Markvart, Merete; Darvann, Tron Andre; Larsen, Per;

    2012-01-01

    AIM: To compare the effectiveness of two rotary hybrid instrumentation techniques with focus on apical enlargement in molar teeth and to quantify and visualize spatial details of instrumentation efficacy in root canals of different complexity. METHODOLOGY: Maxillary and mandibular molar teeth were...... scanned using X-ray microcomputed tomography. Root canals were prepared using either a GT/Profile protocol or a RaCe/NiTi protocol. Variables used for evaluation were the following: distance between root canal surfaces before and after preparation (distance after preparation, DAP), percentage of root...... canal area remaining unprepared and increase in canal volume after preparation. Root canals were classified according to size and complexity, and consequences of unprepared portions of narrow root canals and intraradicular connections/isthmuses were included in the analyses. One- and two-way anova were...

  16. Subcooled He II heat transport in the channel with abrupt contractions/enlargements

    International Nuclear Information System (INIS)

    Heat transport mechanisms for subcooled He II in the channel with abrupt contractions and/or enlargements have been investigated under steady state conditions. The channel, made of G-10, contains various contraction geometries to simulate the cooling channel of a superconducting magnet. In other words, contractions are periodically placed along the channel to simulate the spacers within the magnet winding. A copper block heater inputs the heat to the channel from one end, while the other end is open to the He II bath. Temperature profiles were measured with temperature sensors embedded in the channel as a function of heat input. Calculations were performed using a simple one-dimensional turbulent heat transport equation and with geometric factor consideration. The effects on heat transport mechanisms in He II caused by abrupt change of channel geometry and size are discussed

  17. About a peri-Gondwanan-North African enlarged acceptance of the Caledonian Orogeny

    Directory of Open Access Journals (Sweden)

    Ioan Balintoni

    2011-04-01

    Full Text Available The notion of “Caledonian Orogeny” is restricted by most authors to the Ordovician-Devonian thermotectonic events associated with the Laurentia-Baltica- Avalonia suturing. However, some views consider an orogeny as the sum of tectonic, metamorphic and magmatic events accompanying an entire supercontinent assembly or Wilson cycle. Following this line of thinking, the Caledonian and Variscan orogenies successively assembled Pangea. During the Ordovician Period, rifting, collision, deformation, metamorphism and magmatism took place within the Gondwana margin. All these events are known today in the basement of the Cadomian terranes from Iberia through the Alps up to the Romanian Carpathians and Balkans. We plead here for an enlargement of the “Caledonian Orogeny” terminology to these events and places, under the name of the “Caledonian North African orogenic event" or "Caledonian North African orogeny"

  18. Parotid enlargement due to adenovirus infection in patient with human immunodeficiency virus infection

    Directory of Open Access Journals (Sweden)

    Maria Irma Seixas Duarte

    1996-10-01

    Full Text Available The authors report a case of adenovirus- induced enlargement of the parotid gland involving a patient infected with human immunodeficiency virus (HIV. Physical examination revealed good general condition, no fever and bilateral enlargement of the parotid region, which was of increased consistency and slightly tender to palpation. Histological examination of the parotid gland demonstrated a slight periductal lymphomononuclear inflammatory infiltrate with the presence of focal points of necrosis. Tests to determine the presence of fungi and alcohol-acid resistent bacilli were negative. Immunohistochemistry for cytomegalovirus, heipes simplex, HIV p24 antigen and adenovirus showed positivity only for adenovirus in the epithelial nuclei of numerous gland ducts. Tins is the third case of this type reported in the literature, indicating the importance of including adenovirus in the differential diagnosis of this condition.Os autores relatam um caso de aumento da glândula parótida ocasionado por adenovirus, em paciente infectado pelo vírus da imunodeficiência humana. Ao exame físico, este se apresentava em bom estado geral, afebril e com aumento bilateral de parõtidas, de consistência aumentada e discretamente dolorosas ã palpação. O exame histológico da parótida demonstrou discreto infiltrado inflamatório linfomononuclear periductal com presença de focos de necrose, as pesquisas para fungos e bacilos ãlcool ãcido resistentes foram negativas. A técnica de imuno-histoquímica para citomegalovírus, beipes simples, antígeno p24 do HIVe adenovirus, somente evidenciou posítividade para o último. Este é o terceiro caso descrito na literatura, destacando a importância de incluir o adenovíms, no diagnóstico diferencial, deste acometimento.

  19. Size enlargement of radioactive and hazardous species and their separation by microfiltration and ultrafiltration membranes

    International Nuclear Information System (INIS)

    Separation and volume reduction of aqueous solutions involving membranes is evolving into an expanding and diversified field. Numerous commercially successful membranes and their applications are now available. Among different driving forces used in membrane separation, pressure-driven separation has gained wide application. Depending on the size of the dissolved species in solution to be separated, the pressure needed to achieve the desired separation varies. The microfiltration and ultrafiltration membrane systems are low-pressure processes that generally operate below 350 kPa. To exploit these membranes in applications involving the removal of dissolved contaminants from solutions, it is essential to create a suitable size for the dissolved contaminants, so that the membranes can effectively retain them while producing a filtrate stream essentially free of contaminants. Size enlargement of the dissolved contaminants can be achieved through solution conditioning with the addition of one or a combination of chemical reagents and powdered materials. Examples of typical additives include: pH chemicals, polyelectrolytes, microorganisms and powdered adsorption/ion-exchange materials. In many situations, adequate control and optimization of the system chemistry and hydraulic conditions provide high selectivity and efficiency for contaminant removal. This paper summarizes removal efficiency data for cadmium, lead, mercury, uranium, arsenic, strontium-90/85, cesium-137 and iron. These data resulted from various initiatives on membrane technology undertaken during the past five years by the Waste Processing Technology group at Chalk River Laboratories. The technology involves size enlargement of contaminants present in waste solution, and their separation using either microfiltration or ultrafiltration. The data support remedial applications involving treatment of contaminated groundwater and soils

  20. Blood Flow Simulations for the Design of Stented Valve Reducer in Enlarged Ventricular Outflow Tracts.

    Science.gov (United States)

    Caiazzo, Alfonso; Guibert, Romain; Boudjemline, Younes; Vignon-Clementel, Irene E

    2015-12-01

    Tetralogy of Fallot is a congenital heart disease characterized over time, after the initial repair, by the absence of a functioning pulmonary valve, which causes regurgitation, and by progressive enlargement of the right ventricle outflow tract (RVOT). Due to this pathological anatomy, available transcatheter valves are usually too small to be deployed there. To avoid surgical valve replacement, an alternative consists in implanting a reducer prior to or in combination with the valve. It has been shown in animal experiments to be promising, but with some limitations. The effect of a percutaneous pulmonary valve reducer on hemodynamics in enlarged RVOT is thus studied by computational modeling. To this aim, blood flow in the RVOT is modeled with CFD coupled to a simplified valve model and 0D downstream models. Simulations are performed in an image-based geometry and boundary conditions tuned to reproduce the pathological flow without the device. Different device designs are built and compared with the initial device-free state, or with the reducer alone. Results suggest that pressure loss is higher for the reducer alone than for the full device, and that the latter successfully restores hemodynamics to a healthy state and induces a more symmetric flow in the pulmonary arteries. Moreover, pressure forces on the reducer and on the valve have the same magnitudes. Migration would occur towards the right ventricle rather than the pulmonary arteries. Results support the thesis that the reducer does not introduce clinically significant pressure gradients, as was found in animal experiments. Such study could help transfer to patients. PMID:26577481

  1. Synthesis, characterization and oxygen-sensing performance of a rhenium complex having an enlarged sensing area

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Xiao-yong, E-mail: dreamxxy01@163.com [Center for Functional Materials of Pingxiang, Pingxiang 337055 (China); College of Materials Science and Engineering, Hunan University, Changsha 410082 (China); Deng, Ai-ping; Xiang, Yun [Center for Functional Materials of Pingxiang, Pingxiang 337055 (China)

    2015-04-15

    In this paper, we reported a Re(I) complex Re(CO){sub 3}(IPD-Et)Br having an enlarged conjugation chain for oxygen sensing purpose, where IPD-Et=4-(1-ethyl-1 H-imidazo [4,5-f][1,10] phenanthrolin-2-yl)-N,N-diphenylaniline. Its conjugation chain was composed of triphenylamine group and imidazole group. In addition, an alkyl chain was connected with this N–N ligand to breach π–π attraction between ligand planes. It was assumed that above two factors could improve oxygen sensing sensitivity. Theoretical calculation and analysis firstly confirmed this hypothesis. Then photophysical measurement on Re(CO){sub 3}(IPD-Et)Br suggested that its emission was a lon-lived one peaking at 545 nm and thus vulnerable to molecular O{sub 2}. Composite systems were constructed for oxygen sensing, using Re(CO){sub 3}(IPD-Et)Br as probe and mesoporous silicate MCM-41 as supporting matrix, respectively. Linear Stern–Volmer curves, short response time of ~13 s and high sensitivity of 3.99 were finally obtained. - Highlights: • A Re(I) complex with enlarged but limited conjugation chain for oxygen sensing. • An alkyl chain was connected onto this N–N ligand to breach π–π attraction. • Complex emission peaking at 545 nm owned a long-lived emissive center. • Composite sensing systems were constructed for oxygen sensing. • Linear Stern–Volmer plots, short response time and high sensitivity were obtained.

  2. The Border-making Policy of the European Union: Eastern Enlargement

    Directory of Open Access Journals (Sweden)

    Lika Mkrtchyan

    2012-12-01

    Full Text Available Having no internal borders, what is a border for the European Union (EU? Which criteria does this powerful organization pursue in its decision-making on further expansion: geographical, political, cultural, economic or all of these? What is the profi t of the Union in advancing its external borders to the east? And why to the east and not the south or west across the Atlantic? Does it still mean that there is the reason for enlarging eastward based on the geographical belonging to Europe? This paper discusses the expansion of the European Union to the east with the main focus on its political and economic aspects of integration. The fi rst part includes introduction to the concept of Europe, historic background about the formation of the united Europe in terms of geography, culture, politics and economy, juxtaposing opinions and viewpoints of different experts and political scientists on “what is Europe?” and what are the core issues of its enlargement. The second and third parts are dedicated to the advantages and disadvantages of European Integration for both parties concerned – the EU and the candidate/member state, in the case of the former having its own “demarcation policy” towards certain regions of the continent when it comes to unifi cation. And the fourth part is about the communication and miscommunication of the informative bodies of the European Union that are responsible for public awareness on any process that goes on within the European family. The lack of information results in the ignorance of citizens of European and partner countries, which, of course, refl ects on the further processes of expansion on the political level and cultural perception and mentality on the social level. The conclusion sums up the research, and the bibliography lists the books, articles, monographs and Internet sources used in the course of the study.

  3. Compensatory enlargement of Ossabaw miniature swine coronary arteries in diffuse atherosclerosis

    Directory of Open Access Journals (Sweden)

    Jenny S. Choy

    2015-03-01

    Full Text Available Studies in human and non-human primates have confirmed the compensatory enlargement or positive remodeling (Glagov phenomenon of coronary vessels in the presence of focal stenosis. To our knowledge, this is the first study to document arterial enlargement in a metabolic syndrome animal model with diffuse coronary artery disease (DCAD in the absence of severe focal stenosis. Two different groups of Ossabaw miniature pigs were fed a high fat atherogenic diet for 4 months (Group I and 12 months (Group II, respectively. Group I (6 pigs underwent contrast enhanced computed tomographic angiography (CCTA and intravascular ultrasound (IVUS at baseline and after 4 months of high fat diet, whereas Group II (7 pigs underwent only IVUS at 12 months of high fat diet. IVUS measurements of the left anterior descending (LAD, left circumflex (LCX and right coronary (RCA arteries in Group I showed an average increase in their lumen cross-sectional areas (CSA of 25.8%, 11.4%, and 43.4%, respectively, as compared to baseline. The lumen CSA values of LAD in Group II were found to be between the baseline and 4 month values in Group I. IVUS and CCTA measurements showed a similar trend and positive correlation. Fractional flow reserve (FFR was 0.91 ± 0.07 at baseline and 0.93 ± 0.05 at 4 months with only 2.2%, 1.6% and 1% stenosis in the LAD, LCX and RCA, respectively. The relation between percent stenosis and lumen CSA shows a classical Glagov phenomenon in this animal model of DCAD.

  4. Effect of Corneal Incision Enlargement on Surgically Induced Astigmatism in Biaxial Microincision Cataract Surgery

    Directory of Open Access Journals (Sweden)

    Mehmet Tetikoğlu

    2016-06-01

    Full Text Available Objectives: To evaluate surgically induced astigmatism (SIA in biaxial microincision cataract surgery with enlargement of one corneal incision during intraocular lens implantation (IOL. Materials and Methods: Data from 683 eyes with cataract that underwent biaxial microincision cataract surgery and IOL were retrospectively analyzed. The operated eyes were divided into 4 groups defined by final corneal incision length after IOL implantation. There were 83 eyes with 1.6 mm corneal incisions (group 1 and 200 eyes in each of the 2, 2.4, and 2.8 mm corneal incision groups (groups 2, 3 and 4, respectively. SIA was assessed using preoperative and postoperative keratometric values at one month. Results: The mean magnitude of SIA was 0.83±0.4 D in group 1, 0.93±0.5 D in group 2, 1.03±0.6 D in group 3 and 1.04±0.7 D in group 4. The SIA showed statistically significant differences between the four groups (p=0.05. Pairwise group comparisons revealed significant differences between groups 1 and 3 and groups 1 and 4 (p=0.005. Conclusion: Biaxial microincision cataract surgery with an incision size of 1.6 mm resulted in the least SIA. Enlargement of the corneal incision beyond 2.0 mm during IOL implantation led to significant increases in SIA. We believe that with the development and dissemination of IOLs which can be inserted through small corneal incisions, biaxial microincision cataract surgery will be the best choice to prevent SIA and increase visual acuity

  5. Bronchial compression by an enlarged left atrium in infants; a cause of hypovascularity of the left lung

    Energy Technology Data Exchange (ETDEWEB)

    Corr, L.; Hallidie-Smith, K.A.; McCarthy, P.A.; Lavender, J.P.

    1988-09-01

    In three infants seen recently at our institution we noted signs of compression of the left main bronchus associated with enlarged left atria. None of our cases demonstrated the more usual signs of hyperinflation which are a hyperlucent lung field, depressed hemidiaphragm and mediastinal shift away from the affected side. In addition, hypoperfusion of the left lung was noted in each case. We believe that bronchial compression due to an enlarged left atrium, with consequent hypoxic vasoconstriction is a clinically significant entity, which is not well described and may be unappreciated in infants in whom the typical signs of hyperinflation are absent.

  6. An Improved Genetic Fuzzy Logic Control Method to Reduce the Enlargement of Coal Floor Deformation in Shearer Memory Cutting Process.

    Science.gov (United States)

    Tan, Chao; Xu, Rongxin; Wang, Zhongbin; Si, Lei; Liu, Xinhua

    2016-01-01

    In order to reduce the enlargement of coal floor deformation and the manual adjustment frequency of rocker arms, an improved approach through integration of improved genetic algorithm and fuzzy logic control (GFLC) method is proposed. The enlargement of coal floor deformation is analyzed and a model is built. Then, the framework of proposed approach is built. Moreover, the constituents of GA such as tangent function roulette wheel selection (Tan-RWS) selection, uniform crossover, and nonuniform mutation are employed to enhance the performance of GFLC. Finally, two simulation examples and an industrial application example are carried out and the results indicate that the proposed method is feasible and efficient. PMID:27217824

  7. Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.

    Science.gov (United States)

    Henry, Anastasia G; Aghamohammadzadeh, Soheil; Samaroo, Harry; Chen, Yi; Mou, Kewa; Needle, Elie; Hirst, Warren D

    2015-11-01

    Lysosomal dysfunction plays a central role in the pathogenesis of several neurodegenerative disorders, including Parkinson's disease (PD). Several genes linked to genetic forms of PD, including leucine-rich repeat kinase 2 (LRRK2), functionally converge on the lysosomal system. While mutations in LRRK2 are commonly associated with autosomal-dominant PD, the physiological and pathological functions of this kinase remain poorly understood. Here, we demonstrate that LRRK2 regulates lysosome size, number and function in astrocytes, which endogenously express high levels of LRRK2. Expression of LRRK2 G2019S, the most common pathological mutation, produces enlarged lysosomes and diminishes the lysosomal capacity of these cells. Enlarged lysosomes appears to be a common phenotype associated with pathogenic LRRK2 mutations, as we also observed this effect in cells expressing other LRRK2 mutations; R1441C or Y1699C. The lysosomal defects associated with these mutations are dependent on both the catalytic activity of the kinase and autophosphorylation of LRRK2 at serine 1292. Further, we demonstrate that blocking LRRK2's kinase activity, with the potent and selective inhibitor PF-06447475, rescues the observed defects in lysosomal morphology and function. The present study also establishes that G2019S mutation leads to a reduction in lysosomal pH and increased expression of the lysosomal ATPase ATP13A2, a gene linked to a parkinsonian syndrome (Kufor-Rakeb syndrome), in brain samples from mouse and human LRRK2 G2019S carriers. Together, these results demonstrate that PD-associated LRRK2 mutations perturb lysosome function in a kinase-dependent manner, highlighting the therapeutic promise of LRRK2 kinase inhibitors in the treatment of PD. PMID:26251043

  8. Multiple, thin-walled cysts are one of the HRCT features of airspace enlargement with fibrosis

    International Nuclear Information System (INIS)

    Highlights: • High resolution computed tomography (HRCT) findings of airspace enlargement with fibrosis (AEF), recently identified as a smoking related change. • Investigation was in 35 smokers. • They underwent lobectomy for lung cancer with pathological confirmation of AEF. • Multiple, thin-walled cysts are one of the HRCT features of AEF. - Abstract: Purpose: Airspace enlargement with fibrosis (AEF) has been identified pathologically as a smoking related change. We sought to identify the HRCT findings of AEF and search for distinguishing features from honeycombing. Materials and methods: 50 patients (47 males; mean age 69) were evaluated. All had undergone lobectomy for lung cancer and had confirmed AEF and/or usual interstitial pneumonia (UIP) by pathological evaluation. HRCT findings were first evaluated preresection for resected lobes, and then correlated with the subsequent pathological findings in the resection specimens. Three groups were devised: one with AEF alone to determine the HRCT findings of AEF, a second with AEF and UIP and third with UIP alone. HRCT features of AEF and honeycombing were compared. Results: There were 11 patients (10 male; mean age 69) with AEF alone, 24 patients (22 male; mean age 69) with AEF and UIP, and 15 patients (15 male; mean age 68) with UIP alone. The HRCT on the AEF alone showed subpleural (but not abutting the pleura) multiple thin-walled cysts (MTWCs) in 7 and reticular opacities in 3. The HRCT in AEF and UIP showed MTWCs in 10, reticular opacities in 17; and honeycombing in 5. Among these 35 patients with the pathological finding of AEF (with or without UIP), 17 showed MTWCs. The maximum cyst wall thickness of MTWCs (mean 0.81 mm) was significantly thinner than that of honeycombing (mean 1.56 mm). MTWCs did not locate in lung base and was distant from the pleura. HRCT findings correlated with gross findings on both cysts and honeycombing. No MTWCs were seen in the 15 patients with UIP, 8 of 15 had

  9. A morphological adaptation? The prevalence of enlarged external occipital protuberance in young adults.

    Science.gov (United States)

    Shahar, David; Sayers, Mark G L

    2016-08-01

    Enthesophytes are bony projections that arise from the sites of ligament, tendon or joint capsule attachment to a bone. They are seen rarely in radiographic findings in young adults, as these bony adaptations are assumed to develop slowly over time. However, in recent years, the presence of an enlarged external occipital protuberance (EEOP) has been observed frequently in radiographs of relatively young patients at the clinic of the lead author. Accordingly, the aim of this project was to assess the prevalence of an EEOP in a young adult population. Analysis involved a retrospective analysis of 218 lateral cervical radiographic studies of 18-30-year-old participants. Group A (n = 108; males = 45, females = 63) consisted of asymptomatic university students, while Group B (n = 110; males = 50, females = 60) were an age-matched mildly symptomatic, non-student population. The external occipital protuberance (EOP) size was defined as the distance from the most superior point of the EOP (origin) to a point on the EOP that is most distal from the skull. To avoid ambiguity, the threshold for recording the size of an EOP was set at 5 mm, and an EOP was classified as enlarged if it exceeded 10 mm. Reliability testing was also undertaken. Results indicated that an EEOP was present in 41% of the total population, with 10% of all participants presenting with an EOP ≥ 20 mm. An EEOP was significantly more common in males (67.4%) than in females (20.3%), with the mean EEOP size for the combined male population (15 ± 7 mm) being significantly larger (P < 0.001) than for females (10 ± 4 mm). The longest EEOP in the male population was 35.7 mm, while in the female population it was 25.5 mm. Additionally, the mean EEOP size for Group A (14 ± 7 mm) was also significantly greater (P = 0.006) than that recorded for Group B (12 ± 6 mm). This study identified that an EEOP is a condition that is prevalent in the populations tested. The age of the populations, and the prevalence of

  10. Multiple, thin-walled cysts are one of the HRCT features of airspace enlargement with fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Yasutaka, E-mail: yasuyasu@omiya.jichi.ac.jp [Division of Diagnostic Pathology, Saitama Prefectural Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama 360-0105 (Japan); Division of Pulmonary Medicine, Clinical Department of Internal Medicine, Jichi Medical University, Saitama Medical Center, Amanuma-cho, Omiya City, Saitama 330-8503 (Japan); Kawabata, Yoshinori [Division of Diagnostic Pathology, Saitama Prefectural Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama 360-0105 (Japan); Kanauchi, Tetsu [Department of Radiology, Saitama Prefectural Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama 360-0105 (Japan); Hoshi, Eishin [Department of Thoracic Surgery, Saitama Prefectural Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama 360-0105 (Japan); Kurashima, Kazuyoshi [Department of Pulmonary Medicine, Saitama Prefectural Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama 360-0105 (Japan); Koyama, Shinichiro [Division of Pulmonary Medicine, Clinical Department of Internal Medicine, Jichi Medical University, Saitama Medical Center, Amanuma-cho, Omiya City, Saitama 330-8503 (Japan); Colby, Thomas V. [Department of Laboratory Medicine and Pathology, Mayo Clinic Scottsdale, Scottsdale, AZ 85259 (United States)

    2015-05-15

    Highlights: • High resolution computed tomography (HRCT) findings of airspace enlargement with fibrosis (AEF), recently identified as a smoking related change. • Investigation was in 35 smokers. • They underwent lobectomy for lung cancer with pathological confirmation of AEF. • Multiple, thin-walled cysts are one of the HRCT features of AEF. - Abstract: Purpose: Airspace enlargement with fibrosis (AEF) has been identified pathologically as a smoking related change. We sought to identify the HRCT findings of AEF and search for distinguishing features from honeycombing. Materials and methods: 50 patients (47 males; mean age 69) were evaluated. All had undergone lobectomy for lung cancer and had confirmed AEF and/or usual interstitial pneumonia (UIP) by pathological evaluation. HRCT findings were first evaluated preresection for resected lobes, and then correlated with the subsequent pathological findings in the resection specimens. Three groups were devised: one with AEF alone to determine the HRCT findings of AEF, a second with AEF and UIP and third with UIP alone. HRCT features of AEF and honeycombing were compared. Results: There were 11 patients (10 male; mean age 69) with AEF alone, 24 patients (22 male; mean age 69) with AEF and UIP, and 15 patients (15 male; mean age 68) with UIP alone. The HRCT on the AEF alone showed subpleural (but not abutting the pleura) multiple thin-walled cysts (MTWCs) in 7 and reticular opacities in 3. The HRCT in AEF and UIP showed MTWCs in 10, reticular opacities in 17; and honeycombing in 5. Among these 35 patients with the pathological finding of AEF (with or without UIP), 17 showed MTWCs. The maximum cyst wall thickness of MTWCs (mean 0.81 mm) was significantly thinner than that of honeycombing (mean 1.56 mm). MTWCs did not locate in lung base and was distant from the pleura. HRCT findings correlated with gross findings on both cysts and honeycombing. No MTWCs were seen in the 15 patients with UIP, 8 of 15 had

  11. Nontumorous enlargement of the internal auditory canal. A risk factor for sensorineural hearing loss? A high resolution CT-study

    Energy Technology Data Exchange (ETDEWEB)

    Stimmer, H.; Rummeny, E.J. [Technical University Munich, Klinikum rechts der Isar (Germany). Dept. of Radiology; Niedermeyer, H.P. [Technical University Munich, Klinikum rechts der Isar (Germany). ENT-Clinic; Kehl, V. [Technical University Munich, Klinikum rechts der Isar (Germany). Inst. for Medical Statistics and Epidemiology

    2015-06-15

    First aim of the study was to define normal shape and diameter of the internal auditory canal (IAC). In the second part the clinical relevance of IAC-enlargement was analyzed, considering also lesions of the subtle structures at the fundus of the internal auditory canal. 440 high resolution CT-scans of the temporal bone were used for retrospective analysis of the internal auditory canal and its fundus region. The mean value of the IAC diameter in axial and coronal plane was determined. In 20 of 440 patients IAC enlargement was found. In the group with pronounced enlargement (3fold SD) nearly all patients suffered from hearing impairment. In some of them we found structural abnormalities near the IAC fundus in the CSF/perilymph border zone. A new CT-based definition of normal shape and diameter of the internal auditory canal is presented. There is some evidence that a pathologic transmission of CSF-pressure in case of IAC-enlargement and/or abnormal fistulous communications could play an important role in the pathophysiology of hearing loss.

  12. PC solutions for heat transfer and fluid flow downstream of an abrupt, asymmetric enlargement in a channel

    International Nuclear Information System (INIS)

    An IBM PC was used to obtain finite-difference solutions to a complex heat transfer and fluid flow problem in which the solution domain contained nearly 6000 grid points. The investigated problem was the abrupt, asymmetric enlargement of a parallel-plate channel. The enlargement takes the form of a backward-facing step, the presence of which causes separation of the flow. Heat transfer occurred at the channel wall which extended downstream from the foot of the step. The present velocity solutions were shown to be at least as accurate as prior numerical solutions and served to extend the range of investigated enlargements. The variation of the local Nusselt number with the Reynolds number took on different forms at various axial distances from the enlargement step. In a region extending downstream from the step, the Nusselt number actually decreased monotonically with increasing Reynolds number. Farther downstream, the Nusselt-Reynolds variation was monotonically increasing, while still farther downstream, the Nusselt number was independent of the Reynolds number

  13. An enlarged parietal foramen in the late archaic Xujiayao 11 neurocranium from Northern China, and rare anomalies among Pleistocene Homo.

    Directory of Open Access Journals (Sweden)

    Xiu-Jie Wu

    Full Text Available We report here a neurocranial abnormality previously undescribed in Pleistocene human fossils, an enlarged parietal foramen (EPF in the early Late Pleistocene Xujiayao 11 parietal bones from the Xujiayao (Houjiayao site, northern China. Xujiayao 11 is a pair of partial posteromedial parietal bones from an adult. It exhibits thick cranial vault bones, arachnoid granulations, a deviated posterior sagittal suture, and a unilateral (right parietal lacuna with a posteriorly-directed and enlarged endocranial vascular sulcus. Differential diagnosis indicates that the perforation is a congenital defect, an enlarged parietal foramen, commonly associated with cerebral venous and cranial vault anomalies. It was not lethal given the individual's age-at-death, but it may have been associated with secondary neurological deficiencies. The fossil constitutes the oldest evidence in human evolution of this very rare condition (a single enlarged parietal foramen. In combination with developmental and degenerative abnormalities in other Pleistocene human remains, it suggests demographic and survival patterns among Pleistocene Homo that led to an elevated frequency of conditions unknown or rare among recent humans.

  14. Future systems for regional defence: The case in an enlarged European Union. Report on working group 3

    International Nuclear Information System (INIS)

    Report deals with the future systems for regional defense in case of an enlarged European Union. In the frame of security issues the future of nuclear arms control and disarmament if of concern. The implications of NATO expansion to the east and desirability of establishing a nuclear-weapon-free-zone from the Baltic to the Black Sea are discussed at length

  15. Enlargement of the European Union: Forfás Submission to National Forum on Europe, January 2002

    OpenAIRE

    2002-01-01

    This submission from Forfás has been prepared in response to a request from the National Forum on Europe for submissions on Ireland's experience of and evolving relationship with the European Union, with particular reference to the implications of enlargement of the Union for Ireland.

  16. Minority Language Rights before and after the 2004 EU Enlargement: The Copenhagen Criteria in the Baltic States

    Science.gov (United States)

    Adrey, Jean-Bernard

    2005-01-01

    This paper examines the effect of the recent European Union (EU) enlargement on minority language policies in the Baltic states, and in particular in Latvia and Estonia. I first look at the so-called Copenhagen political criteria conditioning EU accession and at the European Commission's monitoring system for assessing applicant countries'…

  17. The Impact of Globalization and Technology on Teaching Business Communication: Reframing and Enlarging World View, Methods, and Content

    Science.gov (United States)

    Berry, Priscilla

    2013-01-01

    This paper explores the current paradigm shift in the use of technology in the classroom, which is occurring because of technology explosion in society, impact of globalization, necessary reframing, and enlarging of the world view, methods, and content to make business communication classes relevant. The question is whether the classroom should…

  18. Nontumorous enlargement of the internal auditory canal. A risk factor for sensorineural hearing loss? A high resolution CT-study

    International Nuclear Information System (INIS)

    First aim of the study was to define normal shape and diameter of the internal auditory canal (IAC). In the second part the clinical relevance of IAC-enlargement was analyzed, considering also lesions of the subtle structures at the fundus of the internal auditory canal. 440 high resolution CT-scans of the temporal bone were used for retrospective analysis of the internal auditory canal and its fundus region. The mean value of the IAC diameter in axial and coronal plane was determined. In 20 of 440 patients IAC enlargement was found. In the group with pronounced enlargement (3fold SD) nearly all patients suffered from hearing impairment. In some of them we found structural abnormalities near the IAC fundus in the CSF/perilymph border zone. A new CT-based definition of normal shape and diameter of the internal auditory canal is presented. There is some evidence that a pathologic transmission of CSF-pressure in case of IAC-enlargement and/or abnormal fistulous communications could play an important role in the pathophysiology of hearing loss.

  19. Use of MRI to identify enlarged inferior gluteal and ischioanal lymph nodes and associated findings related to the primary disease

    Science.gov (United States)

    Uzun, Çağlar; Erden, Ayşe; Atman, Ebru Düşünceli; Üstüner, Evren

    2016-01-01

    PURPOSE We aimed to draw attention to the lymph nodes at the inferior gluteal and ischioanal regions and evaluate the lesions accompanying them using 3.0 T magnetic resonance imaging (MRI). METHODS In total, 22 patients (15 men, 7 women; mean age, 50±11.2 years; age range, 32–71 years) were included in this study. The patients’ medical records were reviewed. MRI data were reviewed on a picture archiving and communication system workstation by two radiologists in consensus. Lymph node location, laterality, number, and size were documented. RESULTS The primary disorders causing the enlargement of inferior gluteal lymph nodes (n=16) were perianal fistula of cryptoglandular origin (n=5), perianal fistula associated with Crohn’s disease (n=2), decubitus ulcers (n=2), presacral abscess (n=1), non-Hodgkin lymphoma (n=2), prostate cancer invading urethra and anorectal junction (n=1), endometrium cancer invading the urethra and vagina (n=1), and anal cancer (n=2). The pathologies causing the enlargement of ischioanal lymph nodes (n=6) were perianal fistula of cryptoglandular origin (n=4), subcutaneous inflammation of gluteal region related to Crohn’s disease (n=1), and prostate cancer (n=1). CONCLUSION The infectious and neoplastic lesions involving the anal canal, distal rectum, gluteal region, prostate, and urethra are the possible causes of inferior gluteal and ischioanal lymph node enlargement. Lymphoproliferative diseases can also affect these node groups. MRI is an important method to identify enlarged inferior gluteal and ischioanal lymph nodes and define associated findings. PMID:27113423

  20. Spatial bandwidth enlargement and field enhancement of shear horizontal waves in finite graded piezoelectric layered media

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Yanlong, E-mail: xuyanlong814@sina.com

    2015-09-04

    Shear horizontal (SH) wave propagation in finite graded piezoelectric layered media is investigated by transfer matrix method. Different from the previous studies on SH wave propagation in completely periodic layered media, calculations on band structure and transmission in this paper show that the graded layered media possess very large band gaps. Harmonic wave simulation by finite element method (FEM) confirms that the reason of bandwidth enlargement is that waves within the band gap ranges are spatially enhanced and stopped by the corresponding graded units. The study suggests that the graded structure possesses the property of manipulating elastic waves spatially, which shows potential applications in strengthening energy trapping and harvesting. - Highlights: • Shear horizontal wave propagation in finite graded piezoelectric layered media is investigated by transfer matrix method. • Calculations on band structure and transmission show that the graded layered media possess very large band gaps. • Finite element method confirms that waves in band gaps are spatially enhanced and stopped by the graded units. • The study suggests that the graded structure possesses the property of manipulating elastic waves spatially.

  1. Enlargement of visual processing regions in social anxiety disorder is related to symptom severity.

    Science.gov (United States)

    Frick, Andreas; Engman, Jonas; Alaie, Iman; Björkstrand, Johannes; Faria, Vanda; Gingnell, Malin; Wallenquist, Ulrika; Agren, Thomas; Wahlstedt, Kurt; Larsson, Elna-Marie; Morell, Arvid; Fredrikson, Mats; Furmark, Tomas

    2014-11-01

    Social anxiety disorder (SAD) is associated with altered brain function and structure, but most structural studies include small samples and findings are mixed. This study compared regional gray matter volume between 48 SAD patients and 29 healthy controls (HC) as well as the relationship between volume and symptom severity. Structural magnetic resonance images from SAD patients and HC were evaluated using standard voxel-based morphometry (VBM) processing in the SPM8 software package. Social anxiety symptom severity was rated in SAD patients by a clinician using the Liebowitz Social Anxiety Scale (LSAS). SAD patients had greater regional gray matter volume in the lingual gyrus and lateral occipital cortex than the controls, and within the SAD group a positive correlation was found between symptom severity and regional gray matter volume in the lingual gyrus and the retrosplenial cortex. These findings replicate and extend earlier reports of enlarged visual processing areas in SAD. Increased gray matter volume in regions involved in visual processing and self-consciousness could underlie, or be the result of, abnormal emotional information processing and self-focused attention previously demonstrated in patients with SAD. PMID:25258347

  2. Proceedings of the enlargement workshop on Neutron Measurements and Evaluations for Applications - NEMEA

    International Nuclear Information System (INIS)

    The workshop on Neutron Measurements and Evaluation for Applications, NEMEA, was held 5-8 November 2003 in Budapest, Hungary. The objective of this workshop was to strengthen the contacts between laboratories working on nuclear data in member states of the European Union, Accession Countries joining the enlarged Union in 2004, and Candidate Countries which will join later. The workshop was organised by the Neutron Physics unit of the Institute for Reference Materials and Measurements (IRMM) together with the local organisers. The workshop included six sessions and three laboratory visits. The sessions were, in order of the agenda, Material Analysis; Data Evaluation; Safeguards, Illicit Trafficking and Demining; Biology, Medicine and Environment; Single Event Upsets; and Neutron Data for Energy Applications . In total there were thirty-seven presentations of excellent quality, illustrating the many different lines of research featuring neutron measurements and neutron data. Laboratory visits were made to the Atomki and the Institute for Experimental Physics on a one day trip from Budapest to Debrecen and to the KFKI research reactor in Budapest. Both at the Atomki and at the KFKI, laboratory visits were preceded by an excellent comprehensive overview of the facility, its history and its activities. At Debrecen, an overview was provided of the capabilities at the cyclotron laboratory in particular for neutron measurement, while at the Institute for Experimental Physics the neutron generator laboratory and the experimental setup for the demining experiments were shown. At KFKI, the participants were shown the laboratory for PGAA at the neutron beam guides of the reactor

  3. CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex

    Directory of Open Access Journals (Sweden)

    Annabella Pignataro

    2015-01-01

    Full Text Available Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits. Although cAMP response element binding protein (CREB has a key function in spines changes, its role in activity-dependent rearrangements in brain regions of rodents interacting with the surrounding environment has received little attention so far. Here we studied the effects of vibrissae trimming, a widely used model of sensory deprivation-induced cortical plasticity, on processes associated with dendritic spine rearrangements in the barrel cortex of a transgenic mouse model of CREB downregulation (mCREB mice. We found that sensory deprivation through prolonged whisker trimming leads to an increased number of thin spines in the layer V of related barrel cortex (Contra in wild type but not mCREB mice. In the barrel field controlling spared whiskers (Ipsi, the same trimming protocol results in a CREB-dependent enlargement of dendritic spines. Last, we demonstrated that CREB regulates structural rearrangements of synapses that associate with dynamic changes of dendritic spines. Our findings suggest that CREB plays a key role in dendritic spine dynamics and synaptic circuits rearrangements that account for new brain connectivity in response to changes in the environment.

  4. Focal pancreatic enlargement: differentiation between pancreatic adenocarcinoma and focal pancreatitis on CT and ERCP

    International Nuclear Information System (INIS)

    To differentiate the pancreatic adenocarcinoma from focal pancreatitis on CT and ERCP in cases of focal pancreatic enlargement. We analysed CT findings of 66 patients of pancreatic adenocarcinoma (n = 45) or focal pancreatitis (n = 21) with respect to size, density, calcification, pancreatic or biliary duct dilatation, fat plane obliteration around the vessels, direction of retroperitoneal extension, lymphadenopathy, pseudocyst formation and atrophy of pancreas. ERCP available in 48 patients were analysed in respect to morphologic appearance of CBD and pancreatic duct, and distance between the two ducts. The patients in focal pancreatitis were younger with more common history of alcohol drinking. There was no statistical difference in calcifications of the mass (18% in the adenocarcinoma, 33% in the focal pancreatitis), but a tendency of denser, larger number of calcifications was noted in focal pancreatitis. The finding of fat plane obliteration around the vessels were more common in pancreatic adenocarcinoma, and fascial thickenings were more prominent in focal pancreatitis, although not statistically significant. On ERCP, there were no differential points of CBD, pancreatic duct morphology, but distance between the two ducts at the lesion center was more wider in focal pancreatitis. Differentiating focal pancreatitis from pancreatic adenocarcinoma is difficult. However, we should consider the possibility of focal pancreatitis in cases of patients with young age, having alcoholic history in association with CT findings of large numbers of and dense calcifications, and ERCP findings of prominent separation of two duct at the lesion center

  5. Spatial bandwidth enlargement and field enhancement of shear horizontal waves in finite graded piezoelectric layered media

    International Nuclear Information System (INIS)

    Shear horizontal (SH) wave propagation in finite graded piezoelectric layered media is investigated by transfer matrix method. Different from the previous studies on SH wave propagation in completely periodic layered media, calculations on band structure and transmission in this paper show that the graded layered media possess very large band gaps. Harmonic wave simulation by finite element method (FEM) confirms that the reason of bandwidth enlargement is that waves within the band gap ranges are spatially enhanced and stopped by the corresponding graded units. The study suggests that the graded structure possesses the property of manipulating elastic waves spatially, which shows potential applications in strengthening energy trapping and harvesting. - Highlights: • Shear horizontal wave propagation in finite graded piezoelectric layered media is investigated by transfer matrix method. • Calculations on band structure and transmission show that the graded layered media possess very large band gaps. • Finite element method confirms that waves in band gaps are spatially enhanced and stopped by the graded units. • The study suggests that the graded structure possesses the property of manipulating elastic waves spatially

  6. Genetic basis of hearing loss associated with enlarged vestibular aqueducts in Koreans.

    Science.gov (United States)

    Park, H-J; Lee, S-J; Jin, H-S; Lee, J O; Go, S-H; Jang, H S; Moon, S-K; Lee, S-C; Chun, Y-M; Lee, H-K; Choi, J-Y; Jung, S-C; Griffith, A J; Koo, S K

    2005-02-01

    Sensorineural hearing loss associated with enlargement of the vestibular aqueduct (EVA) can be associated with mutations of the SLC26A4 gene. In western populations, less than one-half of the affected individuals with EVA have two mutant SLC26A4 alleles, and EVA is frequently caused by unknown genetic or environmental factors alone or in combination with a single SLC26A4 mutation as part of a complex trait. In this study, we ascertained 26 Korean probands with EVA and performed nucleotide sequence analysis to detect SLC26A4 mutations. All subjects had bilateral EVA, and 20 of 26 were sporadic (simplex) cases. Fourteen different mutations were identified, including nine novel mutations. Five mutations were recurrent and accounted for 80% of all mutant alleles, providing a basis for the design and interpretation of cost-efficient mutation detection algorithms. Two mutant alleles were identified in 21 (81%), one mutant allele was detected in three (11%), and zero mutant allele was detected in two (8%) of 26 probands. The high proportion of Korean probands with two SLC26A4 mutations may reflect a reduced frequency of other genetic or environmental factors causing EVA in comparison to western populations. PMID:15679828

  7. Mobile surveillance units (MSU) for border protection of the enlarged economic union

    Science.gov (United States)

    Crandon, Christopher

    2004-12-01

    During the last 12 years the European Union (EU) has financed the new member applicant countries of Central and Eastern Europe in their preparation for joining the EU. Based on this enlargement of the EU, funding for Cross Border Protection has been made available from the overall infrastructure improvement budget. Border protection was required in areas where border conflicts had taken place and to limit Illegal Immigration (II) and smuggling. After 9/11/2001, defence against terrorist activities will no doubt be added to the requirement. This paper describes the approach taken in the design of the latest "containerised" police and para military Mobile Surveillance Units (MSUs). This approach may also be considered for Homeland Security initiatives. These MSU's utilise standard road vehicles, and off-road variants, converted to use high performance military thermal imagers, such as SiGMA. In future the current, in service, MSUs will require increased sensor integration and networking to cover land and coastal borders. The underlying key is affordability for the police and para-military markets whilst retaining the highest performance derived from the latest SFPA military standard thermal imagers.

  8. Photodynamic therapy of choroidal neovascularization with enlargement of the spot size to include the feeding complex

    Directory of Open Access Journals (Sweden)

    Ilias Georgalas

    2008-12-01

    Full Text Available Ilias Georgalas, Alexandros A Rouvas, Dimitrios A Karagiannis, Athanasios I Kotsolis, Ioannis D LadasDepartment of Ophthalmology, Medical School of Athens University, Athens, GreeceAbstract: This is a case report of a 83-year-old man with choroidal neovascularization (CNV, due to age-related macular degeneration (AMD in his right eye. Digital fluorescein (FA and indocyanine green angiography (ICG were performed, which disclosed predominantly classic subfoveal CNV and a dilated and tortuous feeding complex. The visual acuity was 20/800. Anti-vascular endothelial growth factor (anti-VEGF treatment was suggested, however, the patient was not keen to receive an intraocular injection. Modified photodynamic therapy (PDT with spot size enlarged, to include not only the CNV lesion but the feeding complex as well, was performed. Ten days after one session of PDT, ICG showed absence of leakage from the CNV and complete occlusion of the feeding complex. The visual acuity gradually improved to 20/100 and remained stable during the following 23 months. No evidence of CNV leakage was seen in the FA and ICG during the follow up period. Adjustment of the PDT spot size to include the detectable by ICG feeding complex might be an additional option in order to close the subfoveal CNV and might be considered as an alternative to intravitreal injection of anti-VEGF in selected cases where anti-VEGF treatment is not available.Keywords: age-related macular degeneration, choroidal neovascularization, photodynamic treatment, feeder vessel

  9. Cost of dementia in the pre-enlargement countries of the European Union.

    Science.gov (United States)

    Luengo-Fernandez, Ramon; Leal, Jose; Gray, Alastair M

    2011-01-01

    Dementia has a significant impact on the health and social care systems of the European Union (EU), on patients, on family and friends who provide unpaid care, and on the wider economy and society. Information about its economic burden will be helpful when deciding the allocation of future research funds. We included the 15 countries who were members of the EU (EU-15) before the Eastern enlargement in 2004. The economic burden of dementia was estimated using patient-level studies and aggregate data on morbidity, mortality, and health and social care use. The same methodological approach was used across all countries. Healthcare and social care costs were estimated from expenditure on nursing and residential home care; and primary, outpatient, emergency and inpatient care, as well as drug treatment. Costs of unpaid care and lost earnings due to morbidity and premature death were also included in the study. Dementia was estimated to cost the EU-15 ${\\rm \\euro}$189 billion in 2007. 68% of total costs were due to informal care, 26% to social care, 5% to health care and 1% to productivity losses. In conclusion, dementia poses a significant economic burden to European health and social care systems, and society overall. Our results will be helpful for policy makers in evaluating policy impact and prioritising research expenditures. This study also highlights the need for more accurate and comparable dementia-related data across the European countries. PMID:21860095

  10. Ventricular enlargement in multiple sclerosis: a comparison of three-dimensional and linear MRI estimates

    International Nuclear Information System (INIS)

    Atrophy of central white matter is related to irreversible clinical disability in multiple sclerosis (MS) and ventricular enlargement may be a sensitive marker of this tissue loss. Therapeutic trials in MS have provided MRI data for investigation of cerebral atrophy in MS. These studies use almost exclusively two-dimensional (2-D) images, which may be limited in the assessment of three-dimensional (3-D) structures. We used 3-D MRI data to estimate ventricular volumes in 40 patients with MS and 10 healthy controls, to look at associations with clinical disability and the stage of the disease. We then compared simple linear measures of ventricular size from conventional 2-D images, with 3-D volume estimates to establish the best available linear indices of ventricular volume. Mean ventricular volumes were increased in the patients and significantly larger in the more disabled patients. The estimated volume of the third ventricle obtained from 3-D MRI showed the strongest association with the clinical stage of the disease, duration of symptoms and levels of disability. Finally, we confirmed that in patients with MS accurate data on ventricular size can be obtained from 2-D images by two simple and convenient linear measures, the width of the third ventricle and of the anterior horn of the lateral ventricle. (orig.)

  11. INFORMATION AND RECOMMENDATIONS CONCERNING THE ENLARGED G8 SUMMIT MEETING AT EVIAN

    CERN Multimedia

    2003-01-01

    Despite the difficulties that CERN might encounter, the Organization will pursue its activities for the duration of the G8 Summit Meeting. The Management and Division leaders will take the necessary steps to ensure the proper functioning of the Organization, while taking account of the aforementioned difficulties. The Swiss and French authorities have informed CERN of the following general security and traffic arrangements associated with the enlarged G8 summit: a) Road traffic Between 22 May and 6 June traffic on certain roads in the Canton of Geneva (notably on the left bank) and in neighbouring France (mainly Haute-Savoie) will be disrupted and, in some cases, roads closed. As far as border crossings between 22 May and 4 June are concerned, the frontier posts will be divided into three categories (see map): - posts closed to all traffic (diversion signs will be in place), - posts open at certain times, - posts open at all times. N.B. : the road from Prévessin to Mategnin will be closed and traffic div...

  12. Increased pulse pressure is associated with left atrial enlargement in resistant hypertensive patients.

    Science.gov (United States)

    Armario, Pedro; Oliveras, Anna; Hernández-Del-Rey, Raquel; Suárez, Carmen; Martell, Nieves; Ruilope, Luis M; De La Sierra, Alejandro

    2013-02-01

    Resistant hypertension (RH) is frequently associated with a high prevalence of target organ damage, which impairs the prognosis of these patients. Considering cardiac alterations in RH, most attention has been devoted to left ventricular hypertrophy (LVH), but data concerning left atrial enlargement (LAE) is less known. This cross-sectional study assessed the factors associated with LAE, with special focus on blood pressure (BP) estimates obtained by ambulatory blood pressure monitoring (ABPM), in 250 patients with RH, aged 64 ± 11 years. LAE and LVH were observed in 10.0% (95% CI 6.3-13.7) and 57.1% (95% CI 50.8-63.5) of patients, respectively. Compared with patients with normal atrium size, those exhibiting LAE were older, more frequently women, had elevated pulse pressure (PP) measured both at the office and by ABPM, and showed higher prevalence of LVH (83% vs 54%; p = 0.016). In a logistic regression analysis, adjusting for age, gender, body mass index, left ventricular mass index and BP pressure estimates, night-time PP was independently associated with LAE (OR for 5 mmHg = 1.28, 95% CI 1.24-1.32; p = 0.001). In conclusion, besides classical determinants of LAE, such as age and LVH, an elevated night-time PP was independently associated with LAE in patients with RH. PMID:23305454

  13. The development as enlargement of human capabilities: similarities between Amartya Sen and Celso Furtado

    Directory of Open Access Journals (Sweden)

    Dellany Maria Dantas Souza

    2015-06-01

    Full Text Available The meaning of the term development has been expanded significantly and nowadays there is recognition that mere economic growth is not necessarily synonymous of development. Thus, this article aims to examine the concept of development as the enlargement or the expansion of human capabilities. To achieve this task, it seeks to discuss what is the meaning of development based on the Amartya Sen and Celso Furtado concepts, and then carry out a dialogue with their theories. The methodology used was bibliographical research, applied to the analysis of the texts of the chosen authors for a comparative discussion. During the analysis, there we discovered connections between Sen and Furtado on the essence of development, once the concepts of Expansion of Potentials (Furtado and Extension of Human Capabilities (Amartya Sen are related to the development perspective in its human and social dimension. It was found to be possible to verify a connection between these authors, since development is understood as expansion of human capabilities and that such extension does not occur if the necessary objective conditions for its realization are not assured.JEL-Code | B50; O10; O15.

  14. An ultrasensitive chemiluminescence biosensor for carcinoembryonic antigen based on autocatalytic enlargement of immunogold nanoprobes.

    Science.gov (United States)

    Hao, Minjia; Ma, Zhanfang

    2012-01-01

    A sensitive flow injection chemiluminescence assay for carcinoembryonic antigen (CEA) detection based on signal amplification with gold nanoparticles (NPs) is reported in the present work. The sandwich system of CEA/anti-CEA/goat-anti-mouse IgG functionalized Au nanoparticles was used as the sensing platform. In order to improve detection sensitivity, a further gold enlargement step was developed based on the autocatalytic Au deposition of gold nanoprobes via the reduction of AuCl(4)- to Au0 on their surface in the presence of NH(2)OH·HCl. AuCl(4)-, which is a soluble product of gold nanoprobes, served as an analyte in the CL reaction for the indirect measurement of CEA. Under optimized conditions, the CL intensity of the system was linearly related to the logarithm of CEA concentration in the range of 100 pg∙mL-1 to 1,000 ng∙mL-1, with a detection limit of 20 pg∙mL-1. PMID:23443399

  15. An Ultrasensitive Chemiluminescence Biosensor for Carcinoembryonic Antigen Based on Autocatalytic Enlargement of Immunogold Nanoprobes

    Directory of Open Access Journals (Sweden)

    Minjia Hao

    2012-12-01

    Full Text Available A sensitive flow injection chemiluminescence assay for carcinoembryonic antigen (CEA detection based on signal amplification with gold nanoparticles (NPs is reported in the present work. The sandwich system of CEA/anti-CEA/goat-anti-mouse IgG functionalized Au nanoparticles was used as the sensing platform. In order to improve detection sensitivity, a further gold enlargement step was developed based on the autocatalytic Au deposition of gold nanoprobes via the reduction of AuCl4− to Au0 on their surface in the presence of NH2OH·HCl. AuCl4−, which is a soluble product of gold nanoprobes, served as an analyte in the CL reaction for the indirect measurement of CEA. Under optimized conditions, the CL intensity of the system was linearly related to the logarithm of CEA concentration in the range of 100 pg∙mL−1 to 1,000 ng∙mL−1, with a detection limit of 20 pg∙mL−1.

  16. Treatment Option Overview (Ovarian Germ Cell Tumors)

    Science.gov (United States)

    ... c) cancer cells are found in the pelvic peritoneum. In stage I , cancer is found in one ... in the abdomen ) or in washings of the peritoneum ( tissue lining the peritoneal cavity). Stage II Enlarge ...

  17. Lymphocytes from Enlarged Iliac Lymph Nodes as Fusion Partners for the Production of Monoclonal Antibodies after a Single Tail Base Immunization Attempt

    International Nuclear Information System (INIS)

    A novel method of preparing hybridomas producing mouse monoclonal antibodies was established, called “the mouse iliac lymph node method”. Lymphocytes from enlarged iliac lymph nodes from mice injected intramuscularly at the tail base with an emulsion of antigen and Freund’s adjuvant were used for cell fusion. For the most part, lymph node lymphocytes from two mice were used for a single cell fusion attempt. Ovalbumin was used as the antigen and the results of fusion were compared with the results of a previous report (Cell Struct. Funct. 20; 151–156, 1995). Approximately 100 positive wells producing antibody of interest were identified using this method. By comparison, approximately 10 positive wells were identified using the more conventional mouse spleen method after three immunization injections. The relative proportions of hybridomas producing IgM, IgG1, IgG2a, IgG2b, and IgG3, following fusion using iliac lymph node lymphocytes obtained 14 days after injection were 14.0%, 78.7%, 3.2%, 3.5% and 0.5%, respectively. This method demonstrated the following advantages: (1) a single injection of the antigen emulsion was sufficient, (2) the lymph nodes were ready for use 14 days after injection, and (3) a high yield of positive hybridomas was obtained

  18. Unilateral Versus Bilateral Prostatic Arterial Embolization for Lower Urinary Tract Symptoms in Patients with Prostate Enlargement

    Energy Technology Data Exchange (ETDEWEB)

    Bilhim, Tiago, E-mail: tiagobilhim@hotmail.com [Universidade Nova de Lisboa (UNL), Departamento Universitario de Anatomia, Faculdade de Ciencias Medicas (FCM) (Portugal); Pisco, Joao; Rio Tinto, Hugo; Fernandes, Lucia [Interventional Radiology, Saint Louis Hospital (Portugal); Campos Pinheiro, Luis [Universidade Nova de Lisboa (UNL), Departamento Universitario de Urologia, Faculdade de Ciencias Medicas (FCM) (Portugal); Duarte, Marisa; Pereira, Jose A. [Interventional Radiology, Saint Louis Hospital (Portugal); Oliveira, Antonio G. [Universidade Nova de Lisboa (UNL), Biostatistics Department, Faculdade de Ciencias Medicas (FCM) (Portugal); O' Neill, Joao [Universidade Nova de Lisboa (UNL), Departamento Universitario de Anatomia, Faculdade de Ciencias Medicas (FCM) (Portugal)

    2013-04-15

    This study was designed to compare baseline data and clinical outcome between patients with prostate enlargement/benign prostatic hyperplasia (PE/BPH) who underwent unilateral and bilateral prostatic arterial embolization (PAE) for the relief of lower urinary tract symptoms (LUTS). This single-center, ambispective cohort study compared 122 consecutive patients (mean age 66.7 years) with unilateral versus bilateral PAE from March 2009 to December 2011. Selective PAE was performed with 100- and 200-{mu}m nonspherical polyvinyl alcohol (PVA) particles by a unilateral femoral approach. Bilateral PAE was performed in 103 (84.4 %) patients (group A). The remaining 19 (15.6 %) patients underwent unilateral PAE (group B). Mean follow-up time was 6.7 months in group A and 7.3 months in group B. Mean prostate volume, PSA, International prostate symptom score/quality of life (IPSS/QoL) and post-void residual volume (PVR) reduction, and peak flow rate (Qmax) improvement were 19.4 mL, 1.68 ng/mL, 11.8/2.0 points, 32.9 mL, and 3.9 mL/s in group A and 11.5 mL, 1.98 ng/mL, 8.9/1.4 points, 53.8 mL, and 4.58 mL/s in group B. Poor clinical outcome was observed in 24.3 % of patients from group A and 47.4 % from group B (p = 0.04). PAE is a safe and effective technique that can induce 48 % improvement in the IPSS score and a prostate volume reduction of 19 %, with good clinical outcome in up to 75 % of treated patients. Bilateral PAE seems to lead to better clinical results; however, up to 50 % of patients after unilateral PAE may have a good clinical outcome.

  19. Unilateral Versus Bilateral Prostatic Arterial Embolization for Lower Urinary Tract Symptoms in Patients with Prostate Enlargement

    International Nuclear Information System (INIS)

    This study was designed to compare baseline data and clinical outcome between patients with prostate enlargement/benign prostatic hyperplasia (PE/BPH) who underwent unilateral and bilateral prostatic arterial embolization (PAE) for the relief of lower urinary tract symptoms (LUTS). This single-center, ambispective cohort study compared 122 consecutive patients (mean age 66.7 years) with unilateral versus bilateral PAE from March 2009 to December 2011. Selective PAE was performed with 100- and 200-μm nonspherical polyvinyl alcohol (PVA) particles by a unilateral femoral approach. Bilateral PAE was performed in 103 (84.4 %) patients (group A). The remaining 19 (15.6 %) patients underwent unilateral PAE (group B). Mean follow-up time was 6.7 months in group A and 7.3 months in group B. Mean prostate volume, PSA, International prostate symptom score/quality of life (IPSS/QoL) and post-void residual volume (PVR) reduction, and peak flow rate (Qmax) improvement were 19.4 mL, 1.68 ng/mL, 11.8/2.0 points, 32.9 mL, and 3.9 mL/s in group A and 11.5 mL, 1.98 ng/mL, 8.9/1.4 points, 53.8 mL, and 4.58 mL/s in group B. Poor clinical outcome was observed in 24.3 % of patients from group A and 47.4 % from group B (p = 0.04). PAE is a safe and effective technique that can induce 48 % improvement in the IPSS score and a prostate volume reduction of 19 %, with good clinical outcome in up to 75 % of treated patients. Bilateral PAE seems to lead to better clinical results; however, up to 50 % of patients after unilateral PAE may have a good clinical outcome.

  20. Left atrial enlargement increases the risk of major adverse cardiac events independent of coronary vasodilator capacity

    Energy Technology Data Exchange (ETDEWEB)

    Koh, Angela S. [Brigham and Women' s Hospital, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, MA (United States); National Heart Centre Singapore, Singapore (Singapore); Murthy, Venkatesh L.; Sitek, Arkadiusz; Gayed, Peter; Bruyere, John; Di Carli, Marcelo F. [Brigham and Women' s Hospital, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, MA (United States); Wu, Justina [Brigham and Women' s Hospital, Division of Cardiology, Department of Medicine, and the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Boston, MA (United States); Dorbala, Sharmila [Brigham and Women' s Hospital, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston, MA (United States); Brigham and Women' s Hospital, Department of Radiology and the Division of Cardiology, Noninvasive Cardiovascular Imaging Section, Boston, MA (United States)

    2015-09-15

    Longstanding uncontrolled atherogenic risk factors may contribute to left atrial (LA) hypertension, LA enlargement (LAE) and coronary vascular dysfunction. Together they may better identify risk of major adverse cardiac events (MACE). The aim of this study was to test the hypothesis that chronic LA hypertension as assessed by LAE modifies the relationship between coronary vascular function and MACE. In 508 unselected subjects with a normal clinical {sup 82}Rb PET/CT, ejection fraction ≥40 %, no prior coronary artery disease, valve disease or atrial fibrillation, LAE was determined based on LA volumes estimated from the hybrid perfusion and CT transmission scan images and indexed to body surface area. Absolute myocardial blood flow and global coronary flow reserve (CFR) were calculated. Subjects were systematically followed-up for the primary end-point - MACE - a composite of all-cause death, myocardial infarction, hospitalization for heart failure, stroke, coronary artery disease progression or revascularization. During a median follow-up of 862 days, 65 of the subjects experienced a composite event. Compared with subjects with normal LA size, subjects with LAE showed significantly lower CFR (2.25 ± 0.83 vs. 1.95 ± 0.80, p = 0.01). LAE independently and incrementally predicted MACE even after accounting for clinical risk factors, medication use, stress left ventricular ejection fraction, stress left ventricular end-diastolic volume index and CFR (chi-squared statistic increased from 30.9 to 48.3; p = 0.001). Among subjects with normal CFR, those with LAE had significantly worse event-free survival (risk adjusted HR 5.4, 95 % CI 2.3 - 12.8, p < 0.0001). LAE and reduced CFR are related but distinct cardiovascular adaptations to atherogenic risk factors. LAE is a risk marker for MACE independent of clinical factors and left ventricular volumes; individuals with LAE may be at risk of MACE despite normal coronary vascular function. (orig.)

  1. Development of Romanian Nuclear Power Program implications for future's EU enlargement

    International Nuclear Information System (INIS)

    Energy and transport are two areas for which relations with third countries are crucial. Transport is of course essential in order to ensure smooth movements of people and economic operators within the EU but also with the outside world. Its importance becomes even more apparent in a period characterised by globalization. If modes of transport are the arteries of our society, then energy is the blood. The Green Paper on the security of EU energy supply issued by the Commission shows that whereas the EU economy is energy-intensive, Community energy resources are limited. Consequently, the EU is dependent on external sources of energy, a situation which will not change with the forthcoming enlargement. Hence, most of the EU's external relations include an important chapter on energy. The instrument for applying Romania's pre-accession strategy is the National Programme for Accession (NPAR). I focused on the current situation, short and medium term priorities of the Nuclear Energy as part of the Energy Chapter of the NPAR. In spite of the Romanian Authorities' strong commitment for the completion of Unit2, obtaining the EURATOM loan, for which Societatea Nationala Nuclearelectrica S.A. applied to the European Commission in 1999, remained a critical component of the overall financing requirements of this project. The National Strategy for the Development of the Energy Sector on Medium Term 2001- 2004, as part of our national economic strategy, concludes that on a least-cost basis and considering programs for improving energy efficiency, it is necessary to have Cernavoda Unit 2 in operation by 2006. Finally, are presented the benefits for Romania, as a country involved in the process of European Integration, with a view to obtaining the EURATOM loan and finalizing Cernavoda NPP - Unit2.(author)

  2. Decision making in dissection range of temporal bone: refinements to enlarged translabyrinthine approach.

    Science.gov (United States)

    Zhu, Zheng Jie; Zhu, Wei Dong; Chen, Hong Sai; Wang, Zhao Yan; Wu, Hao

    2016-05-01

    The aim of the study was to describe the refinements to the classic enlarged translabyrinthine approach (ETLA) by modifying the bony dissection range of temporal bone and to analyze the main outcomes achieved in a series of vestibular schwannoma (VS) cases submitted to microsurgery by ETLA. This was a retrospective study of 382 patients who underwent VS surgical removal via ETLA between January 2001 and December 2012. Among those cases, 332 were via classic ETLA, while 28 cases were via ETLA with blind sac technique and middle ear eradication and 22 via transotic approach. Total tumor removal was achieved in 368 cases, whereas near total removal in 11 patients and subtotal in 3 patients. In cases of large VS (>3 cm) via classic ETLA, good short-term and long-term facial nerve function (HB I-II) was gained in 27.8 % (32/115) and 42.6 % (49/115) cases, respectively, meanwhile in VS operated via blind sac technique, good short-term (p = 0.048) and long-term (p = 0.044) facial nerve function was reached in 44.0 % (22/50) and 60.0 % (30/50) cases, respectively. Postoperative facial nerve function was proved to be better in modified ETLA group. CSF leakage occurred in 16 (4.2 %) patients via classic ETLA. In 115 cases of large VS (>3 cm), postoperative CSF leakage occurred in 10 (8.7 %) patients. Whereas in 50 cases via blind sac technique, none developed CSF leakage (p = 0.03). The incidence of CSF leakage was lower in modified ETLA group. Our refinements to classic ETLA by changing the temporal bone resection range provide a wide surgical field, well prevention of CSF leakage and preservation of facial nerve function in large VS. PMID:25997899

  3. Genetic Determinants of Metabolism and Benign Prostate Enlargement: Associations with Prostate Volume.

    Directory of Open Access Journals (Sweden)

    Ayush Giri

    Full Text Available Prostate enlargement leading to clinical benign prostatic hyperplasia (BPH is associated with metabolic dysregulation and obesity. The genetic basis of this association is unclear. Our objective was to evaluate whether single nucleotide polymorphisms (SNPs previously associated with metabolic disorders are also associated with prostate volume (PV. Participants included 876 men referred for prostate biopsy and found to be prostate cancer free. PV was measured by transrectal ultrasound. Samples were genotyped using the Illumina Cardio-MetaboChip platform. Multivariable adjusted linear regression models were used to evaluate SNPs (additive coding in relation to natural-log transformed (log PV. We compared SNP-PV results from biopsy-negative men to 442 men with low-grade prostate cancer with similar levels of obesity and PV. Beta-coefficients from the discovery and replication samples were then aggregated with fixed effects inverse variance weighted meta-analysis. SNP rs11736129 (near the pseudo-gene LOC100131429 was significantly associated with log-PV (beta: 0.16, p-value 1.16x10(-8 after adjusting for multiple testing. Other noteworthy SNPs that were nominally associated (p-value < 1x10(-4 with log-PV included rs9583484 (intronic SNP in COL4A2, rs10146527 (intronic SNP in NRXN3, rs9909466 (SNP near RPL32P31, and rs2241606 (synonymous SNP in SLC12A7. We found several SNPs in metabolic loci associated with PV. Further studies are needed to confirm our results and elucidate the mechanism between these genetic loci, PV, and clinical BPH.

  4. Macrocephaly in infancy: benign enlargement of the subarachnoid spaces and subdural collections.

    Science.gov (United States)

    Tucker, Jacqueline; Choudhary, Arabinda Kumar; Piatt, Joseph

    2016-07-01

    OBJECTIVE Benign enlargement of the subarachnoid spaces (BESS) is a common finding on imaging studies indicated by macrocephaly in infancy. This finding has been associated with the presence of subdural fluid collections that are sometimes construed as suggestive of abusive head injury. The prevalence of BESS among infants with macrocephaly and the prevalence of subdural collections among infants with BESS are both poorly defined. The goal of this study was to determine the relative frequencies of BESS, hydrocephalus, and subdural collections in a large consecutive series of imaging studies performed for macrocephaly and to determine the prevalence of subdural fluid collections among patients with BESS. METHODS A text search of radiology requisitions identified studies performed for macrocephaly in patients ≤ 2 years of age. Studies of patients with hydrocephalus or acute trauma were excluded. Studies that demonstrated hydrocephalus or chronic subdural hematoma not previously recognized but responsible for macrocephaly were noted but not investigated further. The remaining studies were reviewed for the presence of incidental subdural collections and for measurement of the depth of the subarachnoid space. A 3-point scale was used to grade BESS: Grade 0, race, sex, or insurance status with subdural collections. Patients with BESS had larger head circumference Z-scores, but there was no association of head circumference or age with subdural collections. Interrater reliability in the diagnosis and grading of BESS was only fair. CONCLUSIONS The current study confirms the association of BESS with incidental subdural collections and suggests that greater depth of the subarachnoid space is associated with increased prevalence of such collections. These observations support the theory that infants with BESS have a predisposition to subdural collections on an anatomical basis. Incidental subdural collections in the setting of BESS are not necessarily indicative of abusive

  5. Left atrial enlargement increases the risk of major adverse cardiac events independent of coronary vasodilator capacity

    International Nuclear Information System (INIS)

    Longstanding uncontrolled atherogenic risk factors may contribute to left atrial (LA) hypertension, LA enlargement (LAE) and coronary vascular dysfunction. Together they may better identify risk of major adverse cardiac events (MACE). The aim of this study was to test the hypothesis that chronic LA hypertension as assessed by LAE modifies the relationship between coronary vascular function and MACE. In 508 unselected subjects with a normal clinical 82Rb PET/CT, ejection fraction ≥40 %, no prior coronary artery disease, valve disease or atrial fibrillation, LAE was determined based on LA volumes estimated from the hybrid perfusion and CT transmission scan images and indexed to body surface area. Absolute myocardial blood flow and global coronary flow reserve (CFR) were calculated. Subjects were systematically followed-up for the primary end-point - MACE - a composite of all-cause death, myocardial infarction, hospitalization for heart failure, stroke, coronary artery disease progression or revascularization. During a median follow-up of 862 days, 65 of the subjects experienced a composite event. Compared with subjects with normal LA size, subjects with LAE showed significantly lower CFR (2.25 ± 0.83 vs. 1.95 ± 0.80, p = 0.01). LAE independently and incrementally predicted MACE even after accounting for clinical risk factors, medication use, stress left ventricular ejection fraction, stress left ventricular end-diastolic volume index and CFR (chi-squared statistic increased from 30.9 to 48.3; p = 0.001). Among subjects with normal CFR, those with LAE had significantly worse event-free survival (risk adjusted HR 5.4, 95 % CI 2.3 - 12.8, p < 0.0001). LAE and reduced CFR are related but distinct cardiovascular adaptations to atherogenic risk factors. LAE is a risk marker for MACE independent of clinical factors and left ventricular volumes; individuals with LAE may be at risk of MACE despite normal coronary vascular function. (orig.)

  6. Epithelial cell apoptosis causes acute lung injury masquerading as emphysema.

    Science.gov (United States)

    Mouded, Majd; Egea, Eduardo E; Brown, Matthew J; Hanlon, Shane M; Houghton, A McGarry; Tsai, Larry W; Ingenito, Edward P; Shapiro, Steven D

    2009-10-01

    Theories of emphysema traditionally revolved around proteolytic destruction of extracellular matrix. Models have recently been developed that show airspace enlargement with the induction of pulmonary cell apoptosis. The purpose of this study was to determine the mechanism by which a model of epithelial cell apoptosis caused airspace enlargement. Mice were treated with either intratracheal microcystin (MC) to induce apoptosis, intratracheal porcine pancreatic elastase (PPE), or their respective vehicles. Mice from all groups were inflated and morphometry was measured at various time points. Physiology measurements were performed for airway resistance, tissue elastance, and lung volumes. The groups were further analyzed by air-saline quasistatic measurements, surfactant staining, and surfactant functional studies. Mice treated with MC showed evidence of reversible airspace enlargement. In contrast, PPE-treated mice showed irreversible airspace enlargement. The airspace enlargement in MC-treated mice was associated with an increase in elastic recoil due to an increase in alveolar surface tension. PPE-treated mice showed a loss of lung elastic recoil and normal alveolar surface tension, a pattern more consistent with human emphysema. Airspace enlargement that occurs with the MC model of pulmonary epithelial cell apoptosis displays physiology distinct from human emphysema. Reversibility, restrictive physiology due to changes in surface tension, and alveolar enlargement associated with heterogeneous alveolar collapse are most consistent with a mild acute lung injury. Inflation near total lung capacity gives the appearance of enlarged alveoli as neighboring collapsed alveoli exert tethering forces. PMID:19188661

  7. Formations, anomalies and variants of the mediastinum and the lung roots in children, simulating enlarged intrathoracic lymph nodes

    International Nuclear Information System (INIS)

    Timely detection of enlarged intrathoracic lymph nodes is of great importance in pediatric practice. Meanwhile there exist various mediastinal and lung root as well as anomalies and variants of their development, which could imitate the mediastinal lymph node hyperplasia. Their diagnosis is individually designed employing a complex of X-ray methods. In recent years the anatomo-physiological development of thoracic organs in children and teenagers has been affected by the acceleration process. Under the latters' impact the phenomenon of an increase in the large pulmonary vessels appeared in children with signs of high physical development, which caused lung root dilatation and produced an impression of the intrathoracic lymph node enlargement. The Valsalva functional tests should be used in combination with X-ray research methods

  8. EU Enlargement: Migration flows from Central and Eastern Europe into the Nordic countries - exploiting a natural experiment

    DEFF Research Database (Denmark)

    Pytlikova, Mariola; Pedersen, Peder J.

    We look at migration flows from 8 Central and Eastern European Countries (CEECs) to 5 Nordic countries over the years 1985 - 2005 and we can exploit a natural experiment that arose from the fact that while Sweden opened its labour market from the day one of the 2004 EU enlargement, the other Nordic...... countries chose a transition period in relation to the "new" EU members. We employ a differences-in-differences estimator in our analysis. The results show that the estimated effect of the opening of Swedish labour market in 2004 on migration is insignificantly different from zero. Further, we are...... interested in the overall effect of the "EU entry" on migration. Therefore we look at migration flows from CEECs during the first round EU enlargement towards CEECs in 2004 and compare them with migration flows from Bulgaria and Romania. We again used a DD estimator in our analysis. The estimated effect is...

  9. EU Enlargement, Parallel Trade and Price Competition in Pharmaceuticals - What’s to Blame? Derogation or Perception?

    OpenAIRE

    Granlund, David; Yesim Köksal, Miyase

    2012-01-01

    Given the cost of trade and availability of pharmaceuticals, the driving force for parallel trade is the price difference between the source (exporting) and the destination (importing) country. An increase in the price difference or in the availability of pharmaceuticals for parallel trade should increase price competition in the destination country. Using 2003-2007 data from Sweden we investigated whether EU enlargement in 2004, when new countries with low pharmaceutical prices joined the EU...

  10. Accession incentives for institutional change in post-socialist countries: cross-section and country evidence from NATO enlargement

    OpenAIRE

    Schweickert, Rainer; Melnykovska, Inna; Heitmann, Hanno

    2010-01-01

    This paper analyses the transformative power of NATO accession that gains in importance due to the enlargement fatigue of the EU, the EU’s rather weak neighbourhood incentives and the increasing importance of regional security as an incentive for compliance with the institutional standards of democracy and market economy. Econometric cross-country evidence from a hazard model reveals that the entry into NATO’s accession process is mainly driven by neighbourhood and strategic effects rather th...

  11. Risk factors for the syndrome of ventricular enlargement with gait apraxia (idiopathic normal pressure hydrocephalus): a case-control study.

    OpenAIRE

    Casmiro, M; D'Alessandro, R.(INFN Sezione di Firenze, Firenze, Italy); Cacciatore, F M; Daidone, R; Calbucci, F; Lugaresi, E

    1989-01-01

    A case-control study was performed to verify the association between the risk factors for cerebrovascular disease and the syndrome of ventricular enlargement with gait apraxia (VEGAS). This syndrome was defined on the basis of clinical and CT criteria alone; however, it may be representative of patients with idiopathic normal pressure hydrocephalus in whom gait disturbance is the initial symptom. Seventeen patients were matched for age and sex with one hospitalised and two general population ...

  12. Risk identification and risk mitigation during metro station construction by enlarging shield tunnel combined with cut-and-cover method

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Constructing a metro station by enlarging shield tunnels combined with a mining/cut-and-cover method provides a new method to solve the contradictions of construction time limits of shield tunnels and stations. As a new-style construction method, there are several specific risks involved in the construction process. Based on the test section of Sanyuanqiao station on Beijing metro line 10, and combined with the existing methods of risk identification at present, including a review of world-wide operational ...

  13. Europe, Space of Freedom and Security. Migration and mobility: Assets and challenges for the enlargement of the European Union

    OpenAIRE

    Silasi, Grigore; Simina, Ovidiu Laurian

    2006-01-01

    The ‘Jean Monnet’ European Centre of Excellence (C03/0110) and the School of High Comparative European Studies (SISEC), both from the West University of Timisoara, propose to launch the scientific debate on the migration and mobility within the Romanian universities, the academic life and among the policies and decision makers from Romania. The International Colloquium Migration and Mobility: Assets and Challenges for the Enlargement of the European Union proposed for 4-5 of May 2006 is part ...

  14. Cross Border Trade Union Collaboration in the Context of Competition and Arbitraging Labour in an Enlarged Europe

    OpenAIRE

    Hardy, John; Fitzgerald, Ian

    2008-01-01

    An enlarged Europe after the May 2004 and January 2007 accessions has provided more extensive territories over which firms and states can arbitrage labour costs and workers can seek employment. The main aim of the paper is firstly to present a political economy which sees migration and international production as part of wider processes of restructuring in general, and arbitraging labour costs in particular. Second, the paper explores the notion of organised labour as an important contester o...

  15. Nest Enlargement in Leaf-Cutting Ants: Relocated Brood and Fungus Trigger the Excavation of New Chambers

    OpenAIRE

    Daniela Römer; Flavio Roces

    2014-01-01

    During colony growth, leaf-cutting ants enlarge their nests by excavating tunnels and chambers housing their fungus gardens and brood. Workers are expected to excavate new nest chambers at locations across the soil profile that offer suitable environmental conditions for brood and fungus rearing. It is an open question whether new chambers are excavated in advance, or will emerge around brood or fungus initially relocated to a suitable site in a previously-excavated tunnel. In the laboratory,...

  16. Minimal Apical Enlargement for Penetration of Irrigants to the Apical Third of Root Canal System: A Scanning Electron Microscope Study

    OpenAIRE

    P. Srikanth; Krishna, Amaravadi Gopi; Srinivas, Siva; Reddy, E Sujayeendranatha; Battu, Someshwar; Aravelli, Swathi

    2015-01-01

    Background: The aim of this study was to determine minimal apical enlargement for irrigant penetration into apical third of root canal system using scanning electron microscope (SEM). Materials and Methods: Distobuccal canals of 40 freshly extracted human maxillary first molar teeth were instrumented using crown-down technique. The teeth were divided into four test groups according to size of their master apical file (MAF) (#20, #25, #30, #35 0.06% taper), and two control groups. After final ...

  17. Is a Federal European Constitution for an enlarged European Union necessary? Some preliminary suggestions using public choice analysis

    OpenAIRE

    Friedrich G. Schneider

    2009-01-01

    In order to guarantee a further successful functioning of the enlarged European Union a Federal European Constitution is proposed. Six basic elements of a future European federal constitution are developed: the European commission should be turned into an European government and the European legislation should consist of a two chamber system with full responsibility over all federal items. Three further key elements are the subsidiarity principle, federalism and the secession right, which are...

  18. Asymmetric spermatic cord vessel enhancement and enlargement on contrast-enhanced MDCT as indicators of ipsilateral scrotal pathology

    Energy Technology Data Exchange (ETDEWEB)

    Lakhani, Paras, E-mail: paras.lakhani2@uphs.upenn.ed [Department of Radiology, University of Pennsylvania, Philadelphia, PA (United States); Papanicolaou, Nicholas; Ramchandani, Parvati; Torigian, Drew A. [Department of Radiology, University of Pennsylvania, Philadelphia, PA (United States)

    2010-08-15

    Purpose: To determine the association of asymmetric spermatic cord vessel enhancement and enlargement on contrast-enhanced CT with ipsilateral scrotal pathology. Methods: This case series included 30 men with contrast-enhanced CT: 10 cases had asymmetric enhancement and enlargement of spermatic cord vessels with confirmed ipsilateral scrotal pathology determined by additional imaging and/or clinical records; 20 negative reference cases had no such findings with normal corresponding scrotal ultrasound. Maximum spermatic vessel diameters and attenuation values were determined bilaterally. Two blinded radiologists independently assessed all exams for interobserver agreement. Results: For cases, maximum spermatic cord vessel diameters were greater ipsilaterally (5.9 {+-} 1.7 mm) than contralaterally (4.0 {+-} 1.1 mm), p < 0.001. Maximum HU values were greater ipsilaterally (139.5 {+-} 29.5) than contralaterally (70.6 {+-} 17.5), p < 0.0003. Maximum spermatic vessel diameters and attenuation values were significantly greater for positive than negative reference cases (p < 3.9 x 10{sup -8} and p < 4.9 x 10{sup -7} respectively). There was substantial interobserver agreement for asymmetric spermatic vessel enlargement ({kappa} = 0.79) and enhancement ({kappa} = 0.73). In 3 cases, the CT findings lead to a scrotal ultrasound that confirmed the diagnosis and altered patient management. Conclusion: MDCT findings of asymmetric spermatic vessel enlargement and enhancement are indicators of ipsilateral scrotal pathology. The detection of such finings may have implications for patient care and should prompt further evaluation of the scrotum in the proper clinical setting.

  19. Diagnostic criteria for enlarged vestibular aqueduct (EVA) on CT of the temporal bones. Borderline cases of EVA

    International Nuclear Information System (INIS)

    The objective of this study was to examine measurements of the vestibular aqueduct on axial CT figures and to examine the cases with borderline EVA. The width of the vestibular aqueduct was measured in two places, the midpoint of the duct and the external aperture in the posterior cranial fossa. Criteria was as follow: Enlargement; ≥1.5 mm at the midpoint, ≥2 mm at the aperture, Borderline; 1-1.4 mm at the midpoint, 1.5-1.9 mm at the aperture. Three hundred forty-five cases with CT scans of the temporal bones taken during July 2003 to June 2004 in the secondary ENT referral center. Those patients include sensorinearal, mixed or conductive deafness, vertigo, ear infections and other ear diseases. Enlarged vestibular aqueduct was found in 10 ears with sensorineural deafness (SD) and 2 ears without SD. Borderline measurements were found in 19 ears with SD and 33 ears without SD. The enlarged midpoint measurement was not seen in the cases without SD. More than 1.5 mm of the definition for the enlargement at the midpoint of the vestibular aqueduct seemed to be appropriate in the clinical situation. The measurement at the midpoint of the duct is more reliable than at the external aperture. The conductive component in EVA Syndrome with mixed hearing loss is present only at the lower frequencies (250, 500 Hz), not at the middle and higer frequencies. Long-term follow-up of hearing should be done in the borderline cases with check-up of PDS gene anomaly if necessary. (author)

  20. NEW MIGRANTS, NEW COMMUNITIES. POLISH NATIONAL IN IRELAND AFTER THE EU ENLARGEMENT IN 2004

    Directory of Open Access Journals (Sweden)

    Alicja Bobek

    2010-01-01

    Full Text Available Although Poland has been a country of emigration for many decades, Ireland has only recently become a destination country for Polish nationals. Most of the Polish migrants in Ireland came to this country directly prior or after the EU enlargement in May 2004. Therefore this community is still in the process of formation, and rapid changes can be observed. Despite the novelty of this migration fl ow, Polish citizens continue one of the largest immigration groups in Ireland. With the current circumstances of the freedom of movement between European Union states, new light can be put on the concepts of migration, ethnic identity and on such concepts as “home” and “belonging”. The aim of this paper is to describe and examine the process of the formation of Polish community in Ireland, showing how this situation differs from the situation of those Polish communities that have already been well established in other countries and how some patterns from the past are still replicated. The main focus of the paper would be analyze the infl uence of the Information and Communication Technologies on both, ethnic community formation and on the relationship between Polish migrants in Ireland, their local communities “back home” and migrants in other countries. I will argue that the traditional concept of “ethnic neighbourhood” does not apply to this community and it has been, to some extent, compensated by the notion of “virtual community”. I will also show the internal division within the community, which are no longer based on differences between migrants cohorts but rather are based on class and cultural capital characteristics. Finally, I will present the place of this community within the larger context of Polish Diaspora. The paper utilises data from my ongoing research on Polish migrants in Ireland. This research utilises qualitative methodology combining fieldwork, semi-structured interviews and on-line ethnography. In addition

  1. Enlarged symmetry algebras of spin chains, loop models, and S-matrices

    International Nuclear Information System (INIS)

    The symmetry algebras of certain families of quantum spin chains are considered in detail. The simplest examples possess m states per site (m>=2), with nearest-neighbor interactions with U(m) symmetry, under which the sites transform alternately along the chain in the fundamental m and its conjugate representation m-bar. We find that these spin chains, even with arbitrary coefficients of these interactions, have a symmetry algebra Am much larger than U(m), which implies that the energy eigenstates fall into sectors that for open chains (i.e., free boundary conditions) can be labeled by j=0,1,...,L, for the 2L-site chain such that the degeneracies of all eigenvalues in the jth sector are generically the same and increase rapidly with j. For large j, these degeneracies are much larger than those that would be expected from the U(m) symmetry alone. The enlarged symmetry algebra Am(2L) consists of operators that commute in this space of states with the Temperley-Lieb algebra that is generated by the set of nearest-neighbor interaction terms; Am(2L) is not a Yangian. There are similar results for supersymmetric chains with gl(m+n|n) symmetry of nearest-neighbor interactions, and a richer representation structure for closed chains (i.e., periodic boundary conditions). The symmetries also apply to the loop models that can be obtained from the spin chains in a spacetime or transfer matrix picture. In the loop language, the symmetries arise because the loops cannot cross. We further define tensor products of representations (for the open chains) by joining chains end to end. The fusion rules for decomposing the tensor product of representations labeled j1 and j2 take the same form as the Clebsch-Gordan series for SU(2). This and other structures turn the symmetry algebra Am into a ribbon Hopf algebra, and we show that this is 'Morita equivalent' to the quantum group Uq(sl2) for m=q+q-1. The open-chain results are extended to the cases vertical bar m vertical barm or Uq(sl2

  2. Proceedings of the enlargement workshop on Neutron Measurements, Evaluations and Applications, NEMEA-2

    International Nuclear Information System (INIS)

    The Enlargement workshop on Neutron Measurements, Evaluations and Applications, NEMEA-2 was held in Bucharest, Romania on October 20-23, 2004. The workshop was organised by the Neutron Physics Unit of IRMM, in close collaboration with the local organiser and his team from IFIN 'Horia Hulubei' in nearby Magurele. The organisers were assisted by a Program Advisory Committee. The purpose of the workshop was to stimulate exchange of knowledge on recent activities in the field of neutron measurements, evaluations and applications between researchers from new member states, candidate countries, and Western Balkan states with researchers from EU member states and elsewhere, notably Russia. The workshop was opened with an introduction about the status of research in Romania. Following this presentation, the Joint Research Centre and the role of the Institute for Reference Materials and Measurements, situated in Geel, Belgium, was introduced. A further view on the research activities in Romania was offered in four presentations with a relation to the nuclear field. The research activities centered around the separation of tritium in heavy water from the CANDU reactors. An overview was presented of the nuclear power research and development program centered around the dual core 14 MW TRIGA reactor. Dr Rotaru of the Nuclear Electrica Company presented the status and prospects of the CERNAVODA nuclear power plant. The present 700 MWe from unit-1 will be doubled following completion and commissioning of unit-2, scheduled for March 2007. Prof. Zamfir, director of IFIN 'Horia Hulubei', presented the research activities of the insitute. This introduction was complemented by a laboratory visit including the tandem accelerator laboratory, the detector preparation laboratory that is involved in the CERN-based Large Hadron Collider project, the food irradiation facility and the radionuclides laboratory. With forty-three oral and invited contributions and nine posters a wide range of

  3. Enlarged broad band photodetection using Indium doped TiO{sub 2} alloy thin film

    Energy Technology Data Exchange (ETDEWEB)

    Sarkar, Mitra Barun [National Institute of Technology Agartala, Department of Electronics and Communication Engineering, Jirania, Tripura (West) 799055 (India); Mondal, Aniruddha, E-mail: aniruddhamo@gmail.com [National Institute of Technology Agartala, Department of Electronics and Communication Engineering, Jirania, Tripura (West) 799055 (India); Choudhuri, Bijit; Mahajan, Bikram Kishore; Chakrabartty, Shubhro [National Institute of Technology Agartala, Department of Electronics and Communication Engineering, Jirania, Tripura (West) 799055 (India); Ngangbam, Chitralekha [National Institute of Technology Manipur, Department of Electronics and Communication Engineering, Takyelpat, Imphal, Manipur 795001 (India)

    2014-12-05

    Highlights: • An easy technique has been used to dope Indium (instantaneous source) into TiO{sub 2} TF. • An inhomogeneous layer of In{sub x}Ti{sub y}O{sub 2} alloy was formed due to doping. • The lattice constant and optical band gap of TiO{sub 2} has increased after In doping. • Enhanced visible light absorption and detection were recorded for In doped TiO{sub 2} TF. • Almost no delay in photo response for In doped photodetector was observed. - Abstract: An instantaneous source of Indium (In) was used to dope the TiO{sub 2} thin film (TF) on the Si substrate. The X-ray diffraction depicted the presence of rutile phases of TiO{sub 2}, which shifted to the lower value 61.7 from 61.9 (2θ). Secondary ion mass spectrometry (SIMS) reveals that the diffusion of Indium ion yield decreases sharply from the surface, as approached toward the TiO{sub 2} TF–Si substrate interface. The bulk diffusion of In into TiO{sub 2} was observed at a depth of 125–200 nm, up to the edge of TiO{sub 2} TF. An inhomogeneous layer of In{sub x}Ti{sub y}O{sub 2} alloy was formed during annealing process. An average of two fold enhanced photo absorption was recorded for the In doped TiO{sub 2} TF in the 300–350 nm and 450–800 nm regions respectively. The main band gap of In doped TiO{sub 2} was increased to 3.4 eV, whereas the large absorption edge was observed at 3.1 eV. The leakage current (34 nA at −0.5 V) of In doped TiO{sub 2} TF detector was significantly reduced. A maximum 2.5 times (−3.5 V) enlarged photodetection has been observed for In doped TiO{sub 2} TF device under white light illumination. The In doped TiO{sub 2} TF detector shows the broad band photodetection, with an infinitesimal delay in its photo response time as compared to undoped TiO{sub 2} TF.

  4. Bilateral parotid enlargement due to malnutrition under the influence of the media in an adolescent in Lithuania.

    Science.gov (United States)

    Mieliauskaite, Diana; Venalis, Algirdas; Graziene, Vida; Kirdaite, Gailute

    2007-07-01

    The elimination of censorship for the media in post-communist countries in transition has contributed to increases in the prevalence of several medical problems. Children and adolescents are particularly vulnerable to the messages conveyed through the media, which influence their perceptions and behaviour. We describe a case of bilateral parotid enlargement due to malnutrition under the influence of self-prescribed diet in an adolescent. A 15-year-old girl reported to our institution under suspicion of Sjögren's syndrome for medical advice. Two months ago she developed persistent bilateral parotid enlargement and a dry mouth. Her medical history revealed a weight loss due to "self-prescribed" reduce diet. Social questioning clarified high use of the media and influence on the body concept and self image. On extra oral examination, a diffuse parotid enlargement was seen bilaterally. The examination of the mouth showed a low moisture level of the intraoral mucosa. The unstimulated whole salivary flow rate was 2 ml in 15 min. Laboratory findings evidenced anemia (107 g/l). The serum albumin concentration indicated a reduced level (28 g/l). Search for antinuclear antibodies, anti-SSA antibodies, anti-SSB, -Sm, -RNP and anti-double-stranded DNA antibodies was negative. Evaluation for antibodies against hepatitis C, cytomegalovirus and Epstein-Barr virus infection and HIV rendered negative results. A histopathologic examination of labial salivary gland biopsy revealed a picture of sialoadenosis. From the above investigations, a diagnosis of sialoadenosis due to malnutrition was made. PMID:17198741

  5. A novel room temperature-induced chemical etching (RTCE) technique for the enlargement of fission tracks in Lexan polycarbonate SSNTD

    Science.gov (United States)

    Chavan, Vivek; Kalsi, P. C.; Manchanda, V. K.

    2011-02-01

    The chemical or electrochemical etching is an essential step to enlarge the ion-induced latent tracks in solid state nuclear track detectors (SSNTDs). In these methods, above ambient temperatures (˜60 °C) and moderately high concentrations of alkali are required for about 1-2 h to enlarge the latent tracks. Microwave induced chemical etching method is reported to reduce the etching time for alpha tracks from 3 to 4 h to 25 min for CR-39 detector. In the present work, a room temperature-induced chemical etching employing ethanolamine as a new etchant has been investigated for the first time to enlarge the fission tracks in Lexan polycarbonate SSNTD. The tracks developed in the Lexan detectors etched at room temperature using ethanolamine are compared with those etched with routinely used chemical etching (CE) technique in 6 N NaOH at 60 °C. The bulk etch and track etch rates are also reported. The detection efficiency of RTCE method is determined and compared with that of CE method. The RTCE technique is found to be simple, fast and convenient.

  6. A novel room temperature-induced chemical etching (RTCE) technique for the enlargement of fission tracks in Lexan polycarbonate SSNTD

    Energy Technology Data Exchange (ETDEWEB)

    Chavan, Vivek [Radiochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Kalsi, P.C., E-mail: pckalsi@barc.gov.i [Radiochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Manchanda, V.K. [Radiochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2011-02-11

    The chemical or electrochemical etching is an essential step to enlarge the ion-induced latent tracks in solid state nuclear track detectors (SSNTDs). In these methods, above ambient temperatures ({approx}60 {sup o}C) and moderately high concentrations of alkali are required for about 1-2 h to enlarge the latent tracks. Microwave induced chemical etching method is reported to reduce the etching time for alpha tracks from 3 to 4 h to 25 min for CR-39 detector. In the present work, a room temperature-induced chemical etching employing ethanolamine as a new etchant has been investigated for the first time to enlarge the fission tracks in Lexan polycarbonate SSNTD. The tracks developed in the Lexan detectors etched at room temperature using ethanolamine are compared with those etched with routinely used chemical etching (CE) technique in 6 N NaOH at 60 {sup o}C. The bulk etch and track etch rates are also reported. The detection efficiency of RTCE method is determined and compared with that of CE method. The RTCE technique is found to be simple, fast and convenient.

  7. CONSIDERATIONS ON THE IMPACT OF THE EU ENLARGEMENT TOWARDS CENTRAL AND EASTERN EUROPE ON THE EUROPEAN SOCIAL MODEL

    Directory of Open Access Journals (Sweden)

    Constantin Viorel MIHAI

    2009-12-01

    Full Text Available While the European Union keeps taking pride in putting forward the existence of a European Social Model, no study or project was carried out in order to foresee the enlargement effects on this model and mainly how the latter could be successfully implemented by the new Member States, having regard to their own characteristics. It is no coincidence that the references to the European Social Model multiplied during the period when the EU was facing its own enlargement. More and more questions were raised concerning the new Member States convergence capacity, as regards Central and Eastern Europe countries in particular, with all the European Union social rules. The trends in the new Member States, as well as their convictions or their lack of conviction, concerning the European Social Model, have major implications on the tomorrow’s social Europe. In which direction is it heading in an enlarged 25 or 27 nations European Union? This study is aimed at answering at this question having regard, in particular, to the economical and social characteristics of the new Member States and to the possible sources that might give rise to blockings in the social field.

  8. Does Ploidy Level Directly Control Cell Size? Counterevidence from Arabidopsis Genetics

    OpenAIRE

    Tsukaya, Hirokazu

    2013-01-01

    Ploidy level affects cell size in many organisms, and ploidy-dependent cell enlargement has been used to breed many useful organisms. However, how polyploidy affects cell size remains unknown. Previous studies have explored changes in transcriptome data caused by polyploidy, but have not been successful. The most naïve theory explaining ploidy-dependent cell enlargement is that increases in gene copy number increase the amount of protein, which in turn increases the cell volume. This hypothes...

  9. Enlarged symmetry algebras of spin chains, loop models, and S-matrices

    Energy Technology Data Exchange (ETDEWEB)

    Read, N. [Department of Physics, Yale University, PO Box 208120, New Haven, CT 06520-8120 (United States)]. E-mail: nicholas.read@yale.edu; Saleur, H. [Service de Physique Theorique, CEA Saclay, 91191 Gif-sur-Yvette (France) and Department of Physics and Astronomy, University of Southern California, Los Angeles, CA 90089 (United States)]. E-mail: hubert.saleur@cea.fr

    2007-08-20

    The symmetry algebras of certain families of quantum spin chains are considered in detail. The simplest examples possess m states per site (m>=2), with nearest-neighbor interactions with U(m) symmetry, under which the sites transform alternately along the chain in the fundamental m and its conjugate representation m-bar. We find that these spin chains, even with arbitrary coefficients of these interactions, have a symmetry algebra A{sub m} much larger than U(m), which implies that the energy eigenstates fall into sectors that for open chains (i.e., free boundary conditions) can be labeled by j=0,1,...,L, for the 2L-site chain such that the degeneracies of all eigenvalues in the jth sector are generically the same and increase rapidly with j. For large j, these degeneracies are much larger than those that would be expected from the U(m) symmetry alone. The enlarged symmetry algebra A{sub m}(2L) consists of operators that commute in this space of states with the Temperley-Lieb algebra that is generated by the set of nearest-neighbor interaction terms; A{sub m}(2L) is not a Yangian. There are similar results for supersymmetric chains with gl(m+n|n) symmetry of nearest-neighbor interactions, and a richer representation structure for closed chains (i.e., periodic boundary conditions). The symmetries also apply to the loop models that can be obtained from the spin chains in a spacetime or transfer matrix picture. In the loop language, the symmetries arise because the loops cannot cross. We further define tensor products of representations (for the open chains) by joining chains end to end. The fusion rules for decomposing the tensor product of representations labeled j{sub 1} and j{sub 2} take the same form as the Clebsch-Gordan series for SU(2). This and other structures turn the symmetry algebra A{sub m} into a ribbon Hopf algebra, and we show that this is 'Morita equivalent' to the quantum group U{sub q}(sl{sub 2}) for m=q+q{sup -1}. The open-chain results

  10. Effects of migration flows on the host country labour market following the 2004 EU enlargement

    Directory of Open Access Journals (Sweden)

    Peković Drinka

    2011-01-01

    Full Text Available This paper examines the effects of migration flows on unemployment, employment probabilities and native wages. The analysis contains the evaluation of migration effects of labour from Central and Eastern European countries which became European Union member states in 2004, on old member's labour market. Particular emphasis was placed on evidence of the migration flows impact from the new EU member states on the labour market performances in the United Kingdom and Ireland, the countries which did not restrict the access of new member immigrants to their labour markets. The analysis was realized for the period of 2004 to 2008 when the migration inflow was the largest. The empirical literature suggests that the migration effects on unemployment and employment probabilities of natives are very small. The young and low skilled native workers are more affected by migration flows than other groups of workers. Also, most empirical studies show small negative wage effects of immigration. Although the results of public researches and econometric studies have shown the modest potential labour migration flows from new member states and the small potential effects on EU-15 labour market, twelve out of fifteen old member states decided to apply transitional arrangements. The evidence presented in the report of the European Commission pointed out positive EU labour market impact of modest inflow of immigrants from new member states. Sectoral and skill composition of immigrants from new member states suggests their complementary role on EU labour market. The majority of immigrants from new member states are men, aged between 18 and 34, mediumlevel of education. Most immigrants have been employed in service sector, manufacturing and construction. The high employment rate of immigrants from new member states (78% and low unemployment rate (6% in the post-enlargement period have confirmed positive migration impact on EU labour market performances. The unemployment

  11. Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM)

    OpenAIRE

    Goncharova, Elena A; Goncharov, Dmitry A; Fehrenbach, Melane; Khavin, Irene; Ducka, Blerina; HINO, OKIO; Colby, Thomas V.; Merrilees, Mervyn J; Haczku, Angela; Albelda, Steven M.; Krymskaya, Vera P.

    2012-01-01

    Pulmonary lymphangioleiomyomatosis (LAM) is a rare genetic disease characterized by neoplastic growth of atypical smooth muscle–like LAM cells, destruction of lung parenchyma, obstruction of lymphatics, and formation of lung cysts, leading to spontaneous pneumothoraces (lung rupture and collapse) and progressive loss of pulmonary function. The disease is caused by mutational inactivation of the tumor suppressor gene tuberous sclerosis complex 1 (TSC1) or TSC2. By injecting TSC2-null cells int...

  12. Lower Temperature Cultures Enlarge the Effects of Vitreoscilla Hemoglobin Expression on Recombinant Pichia pastoris

    OpenAIRE

    Wei-Chang Fu; Shin-Yao Wang; Jyh-Ming Wu

    2012-01-01

    An heterologous expression of Vitreoscilla hemoglobin (VHb) for improving cell growth and recombinant protein production has been successfully demonstrated in various hosts, including Pichia pastoris. Lower temperature cultures can enhance target protein production in some studies of P. pastoris. In this study, the strategy of combining heterologous VHb expression and lower temperature cultures in P. pastoris showed that final cell density and viability of VHb+ strain at 23 °C were hi...

  13. Hydrodynamics of a three-phase airlift reactor with an enlarged separator : application to high cell density systems

    OpenAIRE

    Klein, Jaroslav; Vicente, A.A.; Teixeira, J.A.

    2003-01-01

    On a mené une étude hydrodynamique d’un réacteur airlift triphasique ayant une zone de tête élargie. On a étudié les effets de la conception des séparateurs gaz-solide-liquide et de la section transversale entre la colonne montante et le déversoir avec différents diamètres et longueurs du tube d’aspiration. Des billes d’alginate de calcium avec de la biomasse de levure piégée à différents taux de charge jusqu’à des taux de charge de 21 % en volume ont été employées afin d’imiter l...

  14. An enlarged largest subunit of Plasmodium falciparum RNA polymerase II defines conserved and variable RNA polymerase domains.

    OpenAIRE

    Li, W B; Bzik, D J; Gu, H M; Tanaka, M.; Fox, B.A.; Inselburg, J

    1989-01-01

    We have isolated the gene encoding the largest subunit of RNA polymerase II from Plasmodium falciparum. The RPII gene is expressed in the asexual erythrocytic stages of the parasite as a 9 kb mRNA, and is present as a single copy gene located on chromosome 3. The P. falciparum RPII subunit is the largest (2452 amino acids) eukaryotic RPII subunit, and it contains enlarged variable regions that clearly separate and define five conserved regions of the eukaryotic RPII largest subunits. A distin...

  15. Evaluation of enlarged images of breast microcalcifications by an LCD monitor. The relations of calcification form and breast carcinoma

    International Nuclear Information System (INIS)

    In 57 patients who underwent stereo-guided mammotome biopsy between September 2005 and July 2006, we evaluated the relationship between the calcification morphology and cancer. The biopsy specimens were radiographed by digital mammography immediately after collection, and calcifications were morphologically examined using enlarged images on an LCD monitor. When morphological and pathological findings were compared, no tumoral lesion was noted even in category 3 if the calcifications were round microcalcifications with no morphological diversity or round ultra-microcalcifications indistinct because of their small sizes. Mammographic follow-up is considered to sufficient for observing such changes. However, biopsy may be necessary for calcifications with morphological diversity or indistinct calcifications. (author)

  16. Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type

    Directory of Open Access Journals (Sweden)

    Nakazawa T

    2011-10-01

    Full Text Available Naoki Chiba, Kazuko Omodaka, Yu Yokoyama, Naoko Aizawa, Satoru Tsuda, Masayuki Yasuda, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan Background: The purpose of this study was to investigate the correlations between microcirculation in the optic disc, average peripapillary retinal nerve fiber layer thickness cupping parameters, and visual field defects in glaucoma patients with the generalized enlargement disc type. Methods: A total of 38 eyes from 38 glaucoma patients with the generalized enlargement disc type were included. The microcirculation of the optic nerve head was examined with laser speckle flow graphy, and the mean blur rate in all areas, in vessel area, and in tissue area were calculated using the laser speckle flow graphy analyzer software. Average peripapillary retinal nerve fiber layer thickness was measured using Stratus optical coherence tomography, and cupping parameters were accessed using the Heidelberg retina tomograph. The mean deviation in the Humphrey field analyzer (30-2 SITA standard was analyzed. The correlation between these parameters was evaluated using the Spearman rank correlation coefficient. Results: The correlation coefficient of mean blur rate in all optic disc area to the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation were r = 0.7546 (P < 0.0001, r = –0.6208 (P < 0.0001, and r = 0.6010 (P = 0.0001, respectively. The mean blur rate in tissue area of the optic disc showed r = 0.7305 (P < 0.0001, r = –0.6438 (P < 0.0001, and r = 0.6338 (P < 0.0001. Conclusion: We found that the mean blur rate in the optic disc was significantly correlated with the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation in patients with the generalized enlargement disc type of glaucoma. In particular, the mean blur rate in tissue area was more

  17. EU Enlargement: Migration flows from Central and Eastern Europe into the Nordic countries - exploiting a natural experiment

    OpenAIRE

    Pedersen, Peder J.; Pytlikova, Mariola

    2008-01-01

    In this paper we look at migration flows from 10 Central and Eastern European Countries (CEEC) to 5 Nordic countries over the years 1985 - 2007. We exploit a natural experiment that arose from the fact that while Sweden opened its labour market from the day one of the 2004 EU enlargement, and Finland and Iceland from year 2006, the other Nordic countries chose a transition period in relation to the "new" EU members. The results based on a differences-in-differences estimator show that the est...

  18. Between enlargement-led Europeanisation and Balkan exceptionalism: an appraisal of Bulgaria’s and Romania’s entry into the European Union

    OpenAIRE

    Papadimitriou, Dimitris; Gativa, Eli

    2009-01-01

    The accession of Bulgaria and Romania into the European Union (EU) in 2007 offers significant theoretical and empirical insights into the way in which the EU has deployed and realised its enlargement strategy/strategies over the past 15 years. Borrowing from the literature on enlargement-led Europeanisation and EU conditionality, this article discusses how the EU has sought to influence domestic reform in the two countries through a mix of threats and rewards. What emerges from Bulgaria’s and...

  19. Treatment Options By Stage (Ovarian Germ Cell Tumors)

    Science.gov (United States)

    ... c) cancer cells are found in the pelvic peritoneum. In stage I , cancer is found in one ... in the abdomen ) or in washings of the peritoneum ( tissue lining the peritoneal cavity). Stage II Enlarge ...

  20. Myocardial ischaemia in children with sickle cell disease

    OpenAIRE

    de Montalembert, M.; Maunoury, C; Acar, P; Brousse, V; Sidi, D; Lenoir, G.

    2004-01-01

    Background: The heart may be involved in children affected with sickle cell disease (SCD) via several mechanisms. Principally, chronic anaemia increases cardiac output and may cause left ventricular enlargement and cardiac insufficiency.

  1. Influence of the benign enlargement of the subarachnoid space on the bridging veins strain during a shaking event: a finite element study.

    Science.gov (United States)

    Raul, Jean-Sébastien; Roth, Sébastien; Ludes, Bertrand; Willinger, Rémy

    2008-07-01

    There is controversy regarding the influence of the benign enlargement of the subarachnoid space on intracranial injuries in the field of the shaken baby syndrome. In the literature, several terminologies exists to define this entity illustrating the lack of unicity on this theme, and often what is "benign" enlargement is mistaken with an old subdural bleeding or with abnormal enlargement due to brain pathology. This certainly led to mistaken conclusions. To investigate the influence of the benign enlargement of the subarachnoid space on child head injury and especially its influence on the bridging veins, we used a finite element model of a 6-month-old child head on which the size of the subarachnoid space was modified. Regarding the bridging veins strain, which is at the origin of the subdural bleeding when shaking an infant, our results show that the enlargement of the subarachnoid space has a damping effect which reduces the relative brain/skull displacement. Our numerical simulations suggest that the benign enlargement of the subarachnoid space may not be considered as a risk factor for subdural bleeding. PMID:18493785

  2. Epithelial Cell Apoptosis Causes Acute Lung Injury Masquerading as Emphysema

    OpenAIRE

    Mouded, Majd; Egea, Eduardo E.; Brown, Matthew J.; Hanlon, Shane M.; Houghton, A. McGarry; Tsai, Larry W; Ingenito, Edward P.; Shapiro, Steven D

    2009-01-01

    Theories of emphysema traditionally revolved around proteolytic destruction of extracellular matrix. Models have recently been developed that show airspace enlargement with the induction of pulmonary cell apoptosis. The purpose of this study was to determine the mechanism by which a model of epithelial cell apoptosis caused airspace enlargement. Mice were treated with either intratracheal microcystin (MC) to induce apoptosis, intratracheal porcine pancreatic elastase (PPE), or their respectiv...

  3. A challenge of regional integration: the Southern Argentinian pipeline enlargement; Desafio de integracao regional: ampliacao do gasoduto Sul-Argentino

    Energy Technology Data Exchange (ETDEWEB)

    Sardi, Oscar; Sosa, Damian [Transportadora de Gas del Sur S.A., Buenos Aires (Argentina); Duarte Filho, Arno [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2005-07-01

    The enlargement of the pipelines of Southern Argentina comprised the construction of around 500 km of 30' and 36' loops in the first semester of 2005 and presented many peculiarities. It has been the first enlargement of the argentinian pipeline system since the country's default statement, in 2001, and it has been financed and built by a bi national Brazilian-Argentinian consortium. It has also been the first time that a governmental trusteeship has been used in such an enterprise in Argentina to guarantee the necessary funds. The increasing demand of natural gas to industries and power generation plants brought about by Argentina's recent growth has stated the sense of urgency: the construction must be on duty in June 2005, ready to increase de flow of gas to the Provincia de Buenos Aires and Great Buenos Aires regions. This has represented also a technical challenge, due to the small time to built the loops, the geographical distribution of the construction, which extends from Patagonia to the Great Buenos Aires region and the meteorological conditions of the period of the construction. The article describes the negotiations done to assemble the construction's financial and managerial frameworks, the building and the solutions found to face the challenge and to meet the deadline. (author)

  4. Hypointensity on postcontrast MR imaging from compression of the sacral promontory in enlarged uterus with huge leiomyoma and adenomyosis

    International Nuclear Information System (INIS)

    In patients with huge leiomyoma and with adenomyosis of the uterus, a peculiar area of hypointensity was occasionally observed on postcontrast magnetic resonance (MR) imaging in the dorsal portion of the enlarged uterus near the sacral promontory. We describe the imaging characteristics of these MR findings and correlate them with histopathological findings to examine whether the areas represent specific pathological changes. Ten patients with huge leiomyomas and two with huge adenomyotic lesions whose imaging revealed the hypointensity were enrolled. All had enlarged uteri that extended beyond the sacral promontory. MR findings of the hypointense areas were evaluated and correlated with histopathological findings in 5 patients with leiomyoma and two with adenomyosis who had hysterectomy. The ten patients with leiomyoma showed flare-shaped hypointensity arising from the dorsal surface of the uterine body that extended deep into the tumor. The base of the hypointense areas was narrow in 5 patients with intramural leiomyoma and broad in five with subserosal leiomyoma. Two patients with adenomyosis showed nodular-shaped areas of hypointensity in front of the sacral promontory. Precontrast T1- and T2-weighted MR images showed no signal abnormalities in the portions corresponding to the hypointensity in any of the 12 patients. Pathological examinations showed no specific findings in the portions corresponding to the hypointensity in the 7 patients who had hysterectomy. The areas of hypointensity may represent functional changes, such as decreased localized blood flow caused by compression of the sacral promontory. (author)

  5. Spleen enlargement is a common finding in acute Puumala hantavirus infection and it does not associate with thrombocytopenia.

    Science.gov (United States)

    Koskela, Sirpa M; Laine, Outi K; Paakkala, Antti S; Mäkelä, Satu M; Mustonen, Jukka T

    2014-10-01

    The pathogenesis of thrombocytopenia in Puumala hantavirus (PUUV) infection is probably multifactorial. We aimed to evaluate the possible spleen enlargement during acute PUUV infection, and to determine its association with thrombocytopenia and disease severity. Magnetic resonance imaging (MRI) of the spleen was performed in 20 patients with acute PUUV infection. MRI was repeated 5-8 months later. The change in spleen length was compared with markers describing the severity of the disease. In all patients, the spleen length was increased in the acute phase compared with the control phase (median 129 mm vs 111 mm, p < 0.001). The change correlated with maximum C-reactive protein value (r = 0.513, p = 0.021) and inversely with maximum leukocyte count (r = -0.471, p = 0.036), but not with maximum serum creatinine level or minimum platelet count. Enlarged spleen, evaluated by MRI, was shown to be a common finding during acute PUUV infection. However, it does not associate with thrombocytopenia and acute kidney injury. PMID:25119440

  6. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.

    Science.gov (United States)

    Pulcini, Serena; Staines, Henry M; Lee, Andrew H; Shafik, Sarah H; Bouyer, Guillaume; Moore, Catherine M; Daley, Daniel A; Hoke, Matthew J; Altenhofen, Lindsey M; Painter, Heather J; Mu, Jianbing; Ferguson, David J P; Llinás, Manuel; Martin, Rowena E; Fidock, David A; Cooper, Roland A; Krishna, Sanjeev

    2015-01-01

    Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P. falciparum lines subjected to selection by amantadine or blasticidin that carry PfCRT mutations (C101F or L272F), causing the development of enlarged food vacuoles. These parasites also have increased sensitivity to chloroquine and some other quinoline antimalarials, but exhibit no or minimal change in sensitivity to artemisinins, when compared with parental strains. A transgenic parasite line expressing the L272F variant of PfCRT confirmed this increased chloroquine sensitivity and enlarged food vacuole phenotype. Furthermore, the introduction of the C101F or L272F mutation into a chloroquine-resistant variant of PfCRT reduced the ability of this protein to transport chloroquine by approximately 93 and 82%, respectively, when expressed in Xenopus oocytes. These data provide, at least in part, a mechanistic explanation for the increased sensitivity of the mutant parasite lines to chloroquine. Taken together, these findings provide new insights into PfCRT function and PfCRT-mediated drug resistance, as well as the food vacuole, which is an important target of many antimalarial drugs. PMID:26420308

  7. Optimizing CT for the evaluation of vestibular aqueduct enlargement:Inter-rater reproducibility and predictive value of reformatted CT measurements

    Institute of Scientific and Technical Information of China (English)

    Misun Hwang; Ryan Marovich; Samuel S. Shin; David Chi; Barton F. Branstetter IV

    2015-01-01

    Enlarged vestibular aqueduct (EVA), the most frequent identifiable cause of congenital hearing loss, is evaluated with high-definition multi-detector CT in the axial plane. Our purpose was to determine which reformatted CT measurements are most reproducible. Seven multiplanar reformatted images were created for each of the 64 temporal bones in patients with EVA. Intraclass correlation coefficients (ICC) were used to assess inter-observer variability, and both linear regression and ROC analyses were used to compare the measurements with severity of hearing loss, as assessed by pure tone audiometry. All seven measurements had excellent inter-observer variability, with average-measure ICC ranging from 0.92 to 0.98. There was no statistically significant correlation between the radiologic degree of aqueduct enlargement and severity of hearing loss using any of the seven measurements;ROC analyses revealed areas under the curves ranging from 0.57 to 0.73. Optimal accuracy was obtained with a threshold of 1.75 mm as measured at the aqueductal aperture in the P€oschl plane, with sensitivity of 0.75 and specificity of 0.63. Although the radiologic measurement may not serve as a reliable tool for assessing severity of EVA, P€oschl plane reformatting has proven to be better than conventional axial acquisition plane for identifying patients with clinically significant hearing loss.

  8. Enlarge the training set based on inter-class relationship for face recognition from one image per person.

    Directory of Open Access Journals (Sweden)

    Qin Li

    Full Text Available In some large-scale face recognition task, such as driver license identification and law enforcement, the training set only contains one image per person. This situation is referred to as one sample problem. Because many face recognition techniques implicitly assume that several (at least two images per person are available for training, they cannot deal with the one sample problem. This paper investigates principal component analysis (PCA, Fisher linear discriminant analysis (LDA, and locality preserving projections (LPP and shows why they cannot perform well in one sample problem. After that, this paper presents four reasons that make one sample problem itself difficult: the small sample size problem; the lack of representative samples; the underestimated intra-class variation; and the overestimated inter-class variation. Based on the analysis, this paper proposes to enlarge the training set based on the inter-class relationship. This paper also extends LDA and LPP to extract features from the enlarged training set. The experimental results show the effectiveness of the proposed method.

  9. Contraindication of ART following a sperm FISH analysis, even though only 12% of the spermatozoa had enlarged heads.

    Science.gov (United States)

    Guthauser, Bruno; Boitrelle, Florence; Albert, Martine; Ketata, Fadoua; Meynant, Celine; Ferfouri, Fatma; Selva, Jacqueline; Vialard, Francois

    2013-08-01

    We report on a couple with a five-year history of idiopathic primary infertility. Two early miscarriages had followed intrauterine insemination (IUI). The man's fertility was then re-evaluated, in order to establish whether or not IUI was the best treatment option. Although the semen parameters were normal (sperm concentration: 89 million/ml; progressive motility: 40%; percentage of typical forms: 20%), a computer-assisted sperm morphology analysis with strict criteria found that 12% of the spermatozoa had enlarged heads. All of the latter had a normal form and none had multiple flagella. Using fluorescence in situ hybridization (FISH) analysis, we found that the proportion of aneuploid and diploid spermatozoa was 78% for the sample as a whole and 68% for normally-shaped spermatozoa with a normal-sized head. Although treatment options are well documented for men with macrocephalic sperm head syndrom, there is no consensus on individuals with a low but non-negligible proportion of spermatozoa with enlarged heads. Here, our FISH results contraindicated the use of assisted reproductive technology with the man's sperm. The couple decided to resort to donor sperm. PMID:23517468

  10. Cell wall proteomics of crops

    OpenAIRE

    Komatsu, Setsuko; Yanagawa, Yuki

    2013-01-01

    Cell wall proteins play key roles in cell structure and metabolism, cell enlargement, signal transduction, responses to environmental stress, and many other physiological events. Agricultural crops are often used for investigating stress tolerance because cultivars with differing degrees of tolerance are available. Abiotic and biotic stress factors markedly influence the geographical distribution and yields of many crop species. Crop cell wall proteomics is of particular importance for improv...

  11. The share of renewable energy in the EU. Country Profiles. Overview of Renewable Energy Sources in the Enlarged European Union

    International Nuclear Information System (INIS)

    The promotion of renewable energy has an important role to play in addressing the growing dependence on energy imports in Europe and in tackling climate change. Since 1997, the Union has been working towards the ambitious target of a 12% share of renewable energy in gross inland consumption by 2010. In 1997, the share of renewable energy was 5.4%; by 2001 it had reached 6%. This Staff Working Document gives an overview of the different situations of renewable energy sources in the European Union. It includes part of the formal report that the Commission is required to make under Article 3 of Directive 2001/77/EC on electricity from renewable energy sources, and it completes the overall picture with information at a country level on the heat produced from renewable energies and biofuels in the transport sector. This Staff Working Document complements the Communication on 'The share of Renewable Energy sources in the EU'. Data is based on different sources. Firstly, on the reports from Member States on national progress in achieving the targets on electricity from renewable energy sources. Secondly, on a study launched by the Commission on the evolution of renewable energy sources. And thirdly, on a variety of sources like the European Barometer of renewable energies, data from the industry, etc. With the enlargement of the European Union, the new Member States are required to adopt the RES-E Directive (renewable energy sources for electricity) by 1 May 2004. In the accession treaty, national indicative targets are set and the overall renewable electricity target for the enlarged Union will therefore be 21% of gross electricity consumption by 2010. The Commission has the legal obligation to report on the degree of achievement of new Member States' targets by 2006. Although it is too early to assess RES-policy in the new Member States due to very recently adopted regulations, this document also includes national information on the States now joining the European Union

  12. Thymus is enlarged in children with current atopic dermatitis. A cross-sectional study

    DEFF Research Database (Denmark)

    Olesen, Anne Braae; Andersen, G.; Jeppesen, D.L.;

    2005-01-01

    Atopic dermatitis is a common skin disorder of unknown aetiology with peak incidence in early childhood. The disease is associated with peripheral T-cell accumulation in the skin. The thymus is a key organ of the cellular immune response early in life. We hypothesized that atopic dermatitis is...... associated with an unbalanced establishment of the peripheral T-lymphocyte system. This cross-sectional study was performed to compare thymus sizes in patients with atopic dermatitis and healthy controls. Thirty-seven children with current atopic dermatitis were enrolled and compared with 29 healthy controls....... An interview and medical examination were performed by one doctor, an ultrasound scan was performed within 3 days of the examination, and the thymus index, a marker of thymus size, was measured. The thymus index was on average 32% higher (95% CI 3%-67%) in children with active atopic dermatitis...

  13. PLMItRNA, a database for tRNAs and tRNA genes in plant mitochondria: enlargement and updating

    Science.gov (United States)

    Volpetti, Vito; Gallerani, Raffaele; De Benedetto, Caterina; Liuni, Sabino; Licciulli, Flavio; Ceci, Luigi R.

    2000-01-01

    The current version of PLMItRNA has been realized to constitute a database for tRNA molecules and genes identified in the mitochondria of all green plants (Viridiplantae). It is the enlargement of a previous database originally restricted to seed plants [Ceci,L.R., Volpicella,M., Liuni,S., Volpetti,V., Licciulli,F. and Gallerani,R. (1999) Nucleic Acids Res., 27, 156–157]. PLMItRNA reports information and multialignments on 254 genes and 16 tRNA molecules detected in 25 higher plants (one bryophyta and 24 vascular plants) and seven green algae. PLMItRNA is accessible via the WWW at http://bio-WWW.ba.cnr.it:8000/srs6/ PMID:10592210

  14. An enlarged largest subunit of Plasmodium falciparum RNA polymerase II defines conserved and variable RNA polymerase domains.

    Science.gov (United States)

    Li, W B; Bzik, D J; Gu, H M; Tanaka, M; Fox, B A; Inselburg, J

    1989-12-11

    We have isolated the gene encoding the largest subunit of RNA polymerase II from Plasmodium falciparum. The RPII gene is expressed in the asexual erythrocytic stages of the parasite as a 9 kb mRNA, and is present as a single copy gene located on chromosome 3. The P. falciparum RPII subunit is the largest (2452 amino acids) eukaryotic RPII subunit, and it contains enlarged variable regions that clearly separate and define five conserved regions of the eukaryotic RPII largest subunits. A distinctive carboxyl-terminal domain contains a short highly conserved heptapeptide repeat domain which is bounded on its 5' side by a highly diverged heptapeptide repeat domain, and is bounded on its 3' side by a long carboxyl-terminal extension. PMID:2690004

  15. EU Enlargement: Migration flows from Central and Eastern Europe into the Nordic countries - exploiting a natural experiment

    DEFF Research Database (Denmark)

    Pedersen, Peder J.; Pytlikova, Mariola

    In this paper we look at migration flows from 10 Central and Eastern European Countries (CEEC) to 5 Nordic countries over the years 1985 - 2007. We exploit a natural experiment that arose from the fact that while Sweden opened its labour market from the day one of the 2004 EU enlargement, and...... Finland and Iceland from year 2006, the other Nordic countries chose a transition period in relation to the "new" EU members. The results based on a differences-in-differences estimator show that the estimated effect of the opening of the Swedish, Finnish and Icelandic labour markets on migration from the...... CEECs that entered the EU in 2004 is not significantly different from zero. However, the effect of the opening of the Swedish and Finnish labour markets in 2007 on migration from the 2007 EU entrants, Bulgaria and Romania, is significantly positive. Further, we are interested in the overall effect of...

  16. Note: Autocollimation with ultra-high resolution and stability using telephoto objective together with optical enlargement and beam drift compensation.

    Science.gov (United States)

    Zhu, Fan; Tan, Xinran; Tan, Jiubin; Fan, Zhigang

    2016-08-01

    An autocollimation (AC) setup with ultra-high resolution and stability for micro-angle measurement is presented. The telephoto objective, which is characterized in long focal length at a compact structure size, and the optical enlargement unit, which can magnify the image displacement to improve its measurement resolution and accuracy, are used to obtain an ultra-high measurement resolution of the AC. The common-path beam drift compensation is used to suppress the drift of measurement results, which is evident in the high-resolution AC, thus to obtain a high measurement stability. Experimental results indicate that an effective resolution of better than 0.0005 arc sec (2.42 nrad) over a measurement range of ±30 arc sec and a 2-h stability of 0.0061 arc sec (29.57 nrad) can be achieved. PMID:27587181

  17. Grain size enlargement of Cu(InGa)Se2 thin films by Hot Filament Melting process

    International Nuclear Information System (INIS)

    Hot Filament Melting (HFM) process has been newly proposed to enlarge the grain size of Cu(In1-xGax)Se2 (CIGS) films grown by a mechanochemical process (MCP). When the substrate temperature was 500 C and 600 C and the current through the hot filament was 15A, we confirmed encouraging the sintering of CIGS grains. Additionally, when the substrate temperature was 700 C, the melt of the CIGS grains at the surface was observed. The crystal structure of CIGS films after the process were analyzed by X-ray diffraction and Raman spectroscopy, and it was found that the CIGS films kept the chalcopyrite structure and that the formation of hetero-phase was not observed. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  18. A reduced-order modeling for efficient design study of artificial valve in enlarged ventricular outflow tracts.

    Science.gov (United States)

    Caiazzo, A; Guibert, R; Vignon-Clementel, I E

    2016-09-01

    A computational approach is proposed for efficient design study of a reducer stent to be percutaneously implanted in enlarged right ventricular outflow tracts (RVOT). The need for such a device is driven by the absence of bovine or artificial valves which could be implanted in these RVOT to replace the absent or incompetent native valve, as is often the case over time after Tetralogy of Fallot repair. Hemodynamics are simulated in the stented RVOT via a reduce order model based on proper orthogonal decomposition, while the artificial valve is modeled as a thin resistive surface. The reduced order model is obtained from the numerical solution on a reference device configuration, then varying the geometrical parameters (diameter) for design purposes. To validate the approach, forces exerted on the valve and on the reducer are monitored, varying with geometrical parameters, and compared with the results of full CFD simulations. Such an approach could also be useful for uncertainty quantification. PMID:26738807

  19. Hearing loss, coloboma and left ventricular enlargement in a boy with an interstitial 10q26 deletion.

    Science.gov (United States)

    Ramos, Maria; Wilkens, Alisha; Krantz, Ian D; Wu, Yaning

    2016-06-01

    Distal deletion of the long arm of chromosome 10 with breakpoints mapped at 10q26 is a well-recognized contiguous genomic disorder. A wide spectrum of clinical findings is seen in affected individuals and the common clinical features include craniofacial dysmorphia, developmental delay, intellectual disability, hypotonia, cardiovascular defects, and urogenital malformations. We report herein on a male patient with a 5.5 Mb interstitial deletion of 10q26.11q2613 and compare his clinical presentation to previously reported cases. Apart from characteristic phenotypes seen in 10q26 deletion syndrome, he presents with colobomas and left ventricle enlargement. These are cardiovascular and ophthalmological findings that have not been described in prior cases. © 2016 Wiley Periodicals, Inc. PMID:27125467

  20. The European Commission in the power relations of the European Union after the 2004–07 enlargement

    Directory of Open Access Journals (Sweden)

    Ekaterina Ostrovskaya

    2014-05-01

    Full Text Available pplying a comparative perspective, this article argues that the current crisis of European Union integration cannot be resolved by member states either transferring additional competences to the EU level or strengthening the intergovernmental dimension of integration. The systemic character of the ongoing process is weakening the institutional structure, which affects both the institutions and their power relations. The European Commission (EC, once a highly independent supranational actor on the eve of the integration process in the 1950s, now faces growing competition from intergovernmental elements in the institutional balance. The theoretical approach of historical neo-institutionalism offers new, useful insights into this research area. The articles uses this theory to analyze the EC’s evolution since the time of its creation in the form of the High Authority of the European Coal and Steel Community, focusing on the links between the gradual changes in its internal structure and its institutional position. Although the phenomenon of “path dependence” was initially present in the EC’s internal systems, the later development of its competences in the institutional balance provoked member states to limit the commission’s activities in the second half of the 1960s. First attempts were made mainly by appointing weak presidents, but the later reform of the EC’s internal structure, undertaken by Neil Kinnock in the beginning of the 21st centry, directed its further structural development as a more technocratic institution. Consequently, the EC was not able to pursue its aims effectively in preparing for its enlargement to include Central and Eastern Europe. The increased heterogeneity of the member states after the 2004–07 enlargement also weakened the EC’s position in the institutional balance, diminishing its traditional function as the “engine of integration.”

  1. Consequences of EU enlargement for supply and demand in the electricity market with special emphasis on nuclear power

    International Nuclear Information System (INIS)

    After the enlargement of the European Union, Europe has acquired a new dimension which is reflected also on the electricity market. The aggregate European electricity requirement of 3 000 TWh in Europe constitutes approximately one quarter of the world electricity generation. Nuclear power contributes a major share of 966 TWh. In electricity generation from nuclear power, EU-25 is No. 1 in the world. The rising demand for electricity cannot be met by the existing power plant park in the next few decades. Insufficient possibilities of exchange among countries and, especially, the enormous requirement to replace more than 200,000 MW of electricity generating capacity in Europe by 2020, plus another 100,000 MW arising from growing demand, make a comprehensive renewal of the European power plant park indispensable. After the EU enlargement, the standards of the ''old'' European Union are the yardstick for the entire ''new'' Union. This gives rise to enormous efforts, especially in the accession countries, to curb emissions and increase safety. The need for modern power plant technology is becoming particularly apparent in these cases. The example of the ten new member countries clearly shows the options realistically available for electricity generation in the future and indispensable for a favorable infrastructure. The conventional energy resources, i. e. coal, gas, and nuclear power, will be the main sources of electricity generation in Europe over the next few decades. This finding does not meet the expectations of many members of the public who feel that renewables would make the largest contribution to power supply in twenty years' time. This makes it imperative to regain popular acceptance in order to ensure electricity generation at favorable conditions and at a high level of environmental protection in the whole of Europe, with enough leeway to further advance the expansion of renewables and support a positive economic development of Europe. (orig.)

  2. Ameloblastic fibrodentinoma presenting as a false gingival enlargement in the maxillary anterior region.

    Science.gov (United States)

    Joseph, Shiny; Priya, Lakshmi; Gopal, Dinesh; Devachen, Mary; Narayan, Ajay; Afnan, Muhammed

    2015-01-01

    Ameloblastic fibrodentinoma is a rare benign mixed odontogenic neoplasm usually occurring in the first two decades of life. It is more common in males and the most common site of occurrence is in the mandibular premolar molar area. This report presents a case of ameloblastic fibrodentinoma in a 12-year-old boy in the maxillary anterior region, a less common site for the occurrence of ameloblastic fibrodentinoma. A 12-year-old boy presented with a midline diastema in 11 and 21 region and a swelling in the palatal aspect of 11 and 12. Intraoral periapical radiograph showed the presence of rarefaction of bone on the mesial aspect of the cervical and middle third of the root of 11. Excision biopsy was done. The specimen was processed and stained with hematoxylin and eosin. Microscopic examination showed islands, chords and strands of odontogenic epithelium in a primitive ectomesenchyme resembling dental papilla. The odontogenic epithelium exhibited peripheral ameloblast-like and central stellate reticulum-like cells. The presence of dentinoid material was seen adjacent to the odontogenic epithelium in some foci. The lesion was diagnosed as ameloblastic fibrodentinoma. PMID:25709845

  3. Ameloblastic Fibrodentinoma Presenting as a False Gingival Enlargement in the Maxillary Anterior Region

    Directory of Open Access Journals (Sweden)

    Shiny Joseph

    2015-01-01

    Full Text Available Ameloblastic fibrodentinoma is a rare benign mixed odontogenic neoplasm usually occurring in the first two decades of life. It is more common in males and the most common site of occurrence is in the mandibular premolar molar area. This report presents a case of ameloblastic fibrodentinoma in a 12-year-old boy in the maxillary anterior region, a less common site for the occurrence of ameloblastic fibrodentinoma. A 12-year-old boy presented with a midline diastema in 11 and 21 region and a swelling in the palatal aspect of 11 and 12. Intraoral periapical radiograph showed the presence of rarefaction of bone on the mesial aspect of the cervical and middle third of the root of 11. Excision biopsy was done. The specimen was processed and stained with hematoxylin and eosin. Microscopic examination showed islands, chords and strands of odontogenic epithelium in a primitive ectomesenchyme resembling dental papilla. The odontogenic epithelium exhibited peripheral ameloblast-like and central stellate reticulum-like cells. The presence of dentinoid material was seen adjacent to the odontogenic epithelium in some foci. The lesion was diagnosed as ameloblastic fibrodentinoma.

  4. Proposal for regulation and enlargement of Gibina from the point of view of development of tourism in Razkrižje

    OpenAIRE

    Rob, Aleš

    2008-01-01

    Community Razkrižje lies in that side of the Pomurje region, where river Mura flows right next to the boarder with Croatia. Expert basis for enlargement and also the analysis of the current situation are introduced in the theoretical part of this work. Area of the community in a broader sense and the village Gibina are introduced in practical part of this work. It also includes the area of the enlargement of the village Gibina and proposal for further development. The stress is on the connect...

  5. The Student with Sickle Cell Anemia.

    Science.gov (United States)

    Tetrault, Sylvia M.

    1981-01-01

    Sickle cell anemia is the most common and severe of inherited chronic blood disorders. In the United States, sickle cell anemia is most common among the Black population. Among the most commonly occurring symptoms are: an enlarged spleen, episodes of severe pain, easily contracted infections, skin ulcers, and frequent urination. (JN)

  6. 小児睾丸Leydig cell tumorの1例

    OpenAIRE

    西野, 昭夫; 高島, 三洋; 中嶋, 和喜; 大川, 光央; 久住, 治男; 橋本, 浩之; 宮川, 和彦; 佐藤, 保; 野々村, 昭孝

    1989-01-01

    A 7-year-old boy was admitted to the department of pediatrics in our hospital with the complaint of sexual precocity manifested by a growth spurt, penile enlargement and pubic hair development. He was referred to our department because of the enlarged left testis. The diagnosis of Leydig cell tumor of the left testis was suggested by hormonal laboratory data and testicular ultrasonographic investigation. Left orchiectomy was performed. The histological examination revealed the characteristics...

  7. The New Environment of EU Enlargement: The Impact of Economic Crisis on the Western Balkans and their EU Accession Prospects

    Directory of Open Access Journals (Sweden)

    Ritsa Panagiotou

    2014-05-01

    Full Text Available This paper will explore the impact of the economic crisis on the Western Balkan countries, and how the new, unfavorable international environment is affecting their EU accession prospects. The analysis will be presented in three sections: the first part will examine the effect of the “first wave” of the global economic crisis on the economies of the region, specifically the impact on the region’s macroeconomic indicators, foreign direct investment flows, financial sectors, etc. Part two will analyse the repercussions of the “second wave” of the crisis, namely the Greek sovereign debt crisis, which rapidly spilled over into the entire Eurozone. Part three will build on the issues examined in parts one and two and will discuss the repercussions of both waves of the crisis on the region’s enlargement process and prospects. The paper will also propose that although the EU’s role in Southeast Europe remains crucial (not least as a provider of economic assistance its hitherto undisputable symbolic role as an “anchor” of stability and as a goal to be aspired to may be losing its appeal for some of these countries. This paper will explore the impact of the economic crisis on the Western Balkan countries, and how the new, unfavorable international environment is affecting their EU accession prospects. The analysis will be presented in three sections: the first part will examine the effect of the “first wave” of the global economic crisis on the economies of the region, specifically the impact on the region’s macroeconomic indicators, foreign direct investment flows, financial sectors, etc. Part two will analyse the repercussions of the “second wave” of the crisis, namely the Greek sovereign debt crisis, which rapidly spilled over into the entire Eurozone. Part three will build on the issues examined in parts one and two and will discuss the repercussions of both waves of the crisis on the region’s enlargement process and

  8. Salivary gland enlargement and sialorrhoea in dogs with spirocercosis: A retrospective and prospective study of 298 cases

    Directory of Open Access Journals (Sweden)

    Liesel L. van der Merwe

    2012-04-01

    Full Text Available This longitudinal cross-sectional clinical study investigated the incidence of sialorrhoea in dogs with spirocercosis and determined whether breed, body weight and the extent of the oesophageal involvement was associated with this presentation. A retrospective analysis was performed on the medical records of 233 dogs and information pertaining to 65 dogs was collected as part of a prospective study. All the animals were client-owned. Patients from the retrospective study underwent thoracic radiography or oesophageal endoscopy to diagnose and characterise the infection and were placed on therapy with a macrocyclic lactone, whereas the patients in the prospective study had both radiography and endoscopy routinely performed and biopsies of the oesophageal nodules collected where possible. Tru-cut biopsies of affected salivary glands were taken in 10 of 13 patients demonstrating clinical signs of sialorrhoea and salivary gland enlargement. The entire salivary gland was sectioned in an additional three dogs with spirocercosis and no sialorrhoea that were presented for post mortem examination. Sialorrhoea was present in 33/298 cases (11%. Fox terrier breeds were over-represented in the patients with sialorrhoea, comprising 36% of cases, whereas they only comprised 1.5% of the patients without sialorrhoea (p < 0.001, chi squared test and 5% of the combined group. Dogs weighing 12 kg or less were significantly over-represented in the sialorrhoea group, 69% versus 19.5% (p < 0.001, chi square test. Age was not significantly different between the two groups (p < 0.08, Mann-Whitney test. The number of oesophageal nodules per case was significantly higher in the non-sialorrhoea cases (p = 0.048, Mann-Whitney test. The prevalence of distal oesophageal and lower oesophageal sphincter involvement, and neoplastic transformation of the nodules were not statistically different between the two groups. None of the fox terriers in either group showed neoplastic

  9. EUROPEAN UNION ENLARGEMENT AS A CULTURAL SHOCK. THE ROLE OF INTERCULTURAL TEAMS’ MANAGEMENT IN INCREASING EUROPEAN COHESION

    Directory of Open Access Journals (Sweden)

    Bibu Nicolae

    2013-07-01

    Full Text Available The European Union is challenged nowadays by a dramatic multilevel process of integration. The Europe 2020 strategy promoting smart, sustainable and inclusive growth is defined by a set of ambitious objectives to be reached by 2020. On the other hand, the turbulent times of the economic crisis put even more pressure on the integration process. The success of this complex endeavor is heavily depending on the dimension of the cohesion specific to each of levels of the process. The cohesion of the European Union (EU is stronger at macro (societal level with regard to institutional, political, and economical dimensions. The cohesion of the European Union is less strong at micro level, the level of people, of the common individual, of the citizen. In other words, EU system has less cohesion at the level of individual and social fabric. An interesting hypothesis about EU enlargement is that every new “wave” of countries is a collective cultural shock for the European citizens. In conclusion, considering the history of the European Union, their citizens were subject to a constant flow of “cultural shocks”, following each new EU enlargement though admission of new member states: the big lot of 10 new countries in 2004, Romania and Bulgaria in 2007. In this respect, immigrations waves from new member countries have preceded their country accession, and to various extents, have made a first impact on the host countries culture. This paper is discussing the issue of increasing European cohesion based on a management approach. It describes the positioning of Romania on the European map of cultures, in order to identify the convergence and divergence of its societal culture with various European cultural clusters. We are arguing that: a European organizations have a major role to play in the process of increasing cohesion within the European Union (EU; b Organizational Management and leadership are paramount to their success and to society welfare; c

  10. Relationship of left atrial enlargement to persistence or development of ECG left ventricular hypertrophy in hypertensive patients: implications for the development of new atrial fibrillation

    DEFF Research Database (Denmark)

    Okin, Peter M; Gerdts, Eva; Wachtell, Kristian;

    2010-01-01

    Persistence and development of ECG left ventricular hypertrophy (LVH) by Cornell product criteria are associated with an increased risk of atrial fibrillation compared with regression or continued absence of LVH. We postulated that this association might be in part mediated via greater left atrial...... enlargement (LAE) in patients with new and persistent ECG LVH....

  11. DETACHED EDDY SIMULATION OF HYDRAULIC CHARACTERISTICS ALONG THE SIDE-WALL AFTER A NEW ARRANGEMENT-SCHEME OF THE SUDDEN LATERAL ENLARGEMENT AND THE VERTICAL DROP

    Institute of Scientific and Technical Information of China (English)

    LI Guo-jing; DAI Guang-qing; YANG Qing; MA Xu-dong

    2011-01-01

    In order to study the cavitation damage in a side-wall when a sudden lateral enlargement and a vertical drop are imposed at the radial gate,a new arrangement-scheme is proposed,where the sudden lateral enlargement and the vertical drop can be imposed at the outlet of the gate chamber.The hydraulic characteristics along the side-wall are simulated by the detached eddy simulation and the Volume Of Fluid (VOF) method.The numerical results agree well with those of experiment.The experimental and numerical results show that the flow condition is smooth with only a weak water-wing appearing behind the lateral cavity,and the length of the lateral cavity becomes longer and is mainly affected by the size of the lateral enlargement and the zone of negative pressure after the water impacts the side-wall would disappear.The hydraulic characteristics of the new arrangement-scheme are beneficial to the prevention of the cavitation damage in the side-wall and the Detached Eddy Simulation (DES) with the VOF method can well predict the hydraulic characteristics after the new arrangement-scheme of the sudden lateral enlargement and the vertical drop.

  12. Independent and incremental value of severely enlarged left atrium in risk stratification of very elderly patients with chronic systolic heart failure.

    Science.gov (United States)

    Bajraktari, Gani; Fontanive, Paolo; Qirko, Spiro; Elezi, Shpend; Simioniuc, Anca; Huqi, Alda; Berisha, Venera; Dini, Frank L

    2012-01-01

    The authors sought to assess the impact on survival of demographic, clinical, and echo-Doppler parameters in patients with chronic heart failure due to left ventricular systolic dysfunction divided according to age groups. This study included 734 patients (age 69±11 years) who were classified into tertiles of age: I (22-66 years), II (67-76 years), and III (77-94 years). Severely enlarged left atrial size was defined as ≥52 mm in men and ≥47 mm in women. Multivariable analysis identified male sex (P=.018) and severely enlarged left atrium (P=.024) as significant correlates of all-cause mortality in the very elderly cohort, while restrictive filling pattern (RFP) (P=.004) and New York Heart Association class III or IV (P=.005) among patients of the first tertile and RFP (P=.028) among patients in the second tertile were independently associated with mortality after 30±21 months of follow-up. At the interactive stepwise model in the very elderly population, a severely enlarged left atrium, added to the model after clinical parameters and ejection fraction, moved the chi-square value from 20.7 to 25.8 (P=.048). RFP emerged as the single best predictor of all-cause mortality in the younger and intermediate ranges, whereas severely enlarged left atrium was the best predictor in the very elderly. PMID:22520934

  13. SLC26A4 gene copy number variations in Chinese patients with non-syndromic enlarged vestibular aqueduct

    Directory of Open Access Journals (Sweden)

    Zhao Jiandong

    2012-05-01

    Full Text Available Abstract Background Many patients with enlarged vestibular aqueduct (EVA have either only one allelic mutant of the SLC26A4 gene or lack any detectable mutation. In this study, multiplex ligation-dependent probe amplification (MLPA was used to screen for copy number variations (CNVs of SLC26A4 and to reveal the pathogenic mechanisms of non-syndromic EVA (NSEVA. Methods Between January 2003 and March 2010, 923 Chinese patients (481 males, 442 females with NSEVA were recruited. Among these, 68 patients (7.4% were found to carry only one mutant allele of SLC26A4 and 39 patients (4.2% lacked any detectable mutation in SLC26A4; these 107 patients without double mutant alleles were assigned to the patient group. Possible copy number variations in SLC26A4 were detected by SALSA MLPA. Results Using GeneMapper, no significant difference was observed between the groups, as compared with the standard probe provided in the assay. The results of the capillary electrophoresis showed no significant difference between the patients and controls. Conclusion Our results suggest that CNVs and the exon deletion in SLC26A4 are not important factors in NSEVA. However, it would be premature to conclude that CNVs have no role in EVA. Genome-wide studies to explore CNVs within non-coding regions of the SLC26A4 gene and neighboring regions are warranted, to elucidate their roles in NSEVA etiology.

  14. Synthesis of gold nano particles with enlargement size by gamma Co-60 irradiation and investigation of anti oxidation effect

    International Nuclear Information System (INIS)

    Gold nanoparticles (AuNPs) with size in the range of 10-53 nm were synthesized by gamma Co-60 irradiation using water-soluble chitosan (WSC) as stabilizer and size enlargement by seed approach. Absorption wavelength (λmax) was measured by UV-Vis spectroscopy and particle size was determined from TEM images. Results showed that value of λmax increased from 523 nm (seed particles) to 525, 537 and 549 nm and the size of AuNPs increased from 10 nm (seed particles) to 20, 38 and 53 nm, respectively, for concentration ratio of Au3+/Au0 (seed) of 2.5, 5 and 10. Antioxidant effect of AuNPs with size of 10, 20, 38 and 53 nm was investigated using free radical 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS.+). Results indicated that the smaller the particle size was (10 nm) the stronger the antioxidant effect attained. Thus, AuNPs/WSC synthesis by gamma Co-60 irradiation are promising for applications as antioxidants in cosmetics and in other fields as well. (author)

  15. Serial MRI of vestibular schwannoma presenting transient enlargement associated with intratumoral hemorrhage following radiosurgery. Two case reports

    International Nuclear Information System (INIS)

    Two cases of vestibular schwannoma showing transient enlargement with hemorrhage that was recognized on T2 or T2*-weighted MR image are reported. Case 1: A 72-year-old woman had a recurrent cystic lesion after resection and stereotactic radiosurgery (SRS). After retreatment by gamma knife radiosurgery, the cystic component further expanded with a fluid-fluid level, and T2 or T2*-weighted image showed markedly-low signal in the parenchymal component. Chronic hemorrhage from the cyst wall injured by irradiation is probably related to expansion of the cyst. Case 2: A 59-year-old woman received SRS. Serial MRI scans demonstrated a lesion continually expanding with homogeneous contrast enhancement on T1-weighted images. At 64 months after treatment, a central portion with high blood flow surrounded by a markedly-low intensity component of apparent hemorrhage on T2*-weighted MRI was identified. The lesion decreased in size after 73 months. Hemorrhage might occur from the neogenetic angioma-like tissue induced by irradiation effect in the tumor. Based on these observations, microvasculopathy associated with irradiation is a probable mechanism that induces bleeding in vestibular schwannoma following radiosurgery. (author)

  16. A new method to enlarge a range of continuously perceived depth in DFD (depth-fused 3D) display

    Science.gov (United States)

    Tsunakawa, Atsuhiro; Soumiya, Tomoki; Horikawa, Yuta; Yamamoto, Hirotsugu; Suyama, Shiro

    2013-03-01

    We can successfully solve the problem in DFD display that the maximum depth difference of front and rear planes is limited because depth fusing from front and rear images to one 3-D image becomes impossible. The range of continuously perceived depth was estimated as depth difference of front and rear planes increases. When the distance was large enough, perceived depth was near front plane at 0~40 % of rear luminance and near rear plane at 60~100 % of rear luminance. This maximum depth range can be successfully enlarged by spatial-frequency modulation of front and rear images. The change of perceived depth dependence was evaluated when high frequency component of front and rear images is cut off using Fourier Transformation at the distance between front and rear plane of 5 and 10 cm (4.9 and 9.4 minute of arc). When high frequency component does not cut off enough at the distance of 5 cm, perceived depth was separated to near front plane and near rear plane. However, when the images are blurred enough by cutting high frequency component, the perceived depth has a linear dependency on luminance ratio. When the images are not blurred at the distance of 10 cm, perceived depth is separated to near front plane at 0~30% of rear luminance, near rear plane at 80~100 % and near midpoint at 40~70 %. However, when the images are blurred enough, perceived depth successfully has a linear dependency on luminance ratio.

  17. 5-Alpha reductase inhibitors in men with an enlarged prostate: an evaluation of outcomes and therapeutic alternatives.

    Science.gov (United States)

    Naslund, Michael; Regan, Timothy S; Ong, Christine; Hogue, Susan L

    2008-05-01

    This article presents background information and highlights key findings from a managed care perspective related to enlarged prostate (EP) in Medicare-eligible patients. This article does not provide a comprehensive review of EP but instead attempts to increase the current understanding of EP through discussion of its prevalence in men aged > or =65 years, its associated economic burden, and some available treatment options. This supplement includes 3 additional articles, all of which present data from a naturalistic, managed care setting. The article by Fenter et al assesses differences in outcomes between elderly EP patients treated with finasteride and those treated with dutasteride in relation to the risks of acute urinary retention and prostate-related surgery. Issa et al conduct a comparative analysis of the combined use of alpha-blockers and 5-alpha reductase inhibitors to treat EP. The final article compares medical costs incurred within the first year of initiating treatment for EP patients receiving finasteride versus dutasteride. This supplement is intended to assist managed care formulary decision makers in evaluating key clinical and economic data that differentiate dutasteride and finasteride within the Medicare-aged population. Although the information presented is not designed to illustrate the superiority of one product over the other, it answers important questions in relation to treating EP in elderly men and raises substantial issues beyond medication costs. PMID:18611088

  18. A Case of Adenomatous Goiter Involving Diffuse, Acute, and Painful Thyroid Enlargement after Fine-Needle Aspiration Cytology

    Directory of Open Access Journals (Sweden)

    Toshiro Shimo

    2014-01-01

    Full Text Available The patient was a 44-year-old woman who exhibited a diffuse goiter during health screening. Her medical history did not include any significant medication-based treatment. An echographic examination detected a solid cystic tumor, which measured 21 × 14 × 10 mm, in her right thyroid lobe; however, she displayed normal thyroid function. After fine-needle aspiration cytology had been performed with a 22 G injection needle, the patient immediately complained of compression and pain extending from the front of her neck to her lower chin, which was not accompanied by dyspnea. A second echographic examination revealed diffuse and edematous enlargement and increased internal blood flow in the bilateral thyroid lobes as well as a thyroid nodule. We immediately iced the patient’s neck and administered 125 mg methylprednisolone via an intravenous infusion. Within one hour, her symptoms had markedly improved, but acute pain remained. Thus, we continued the steroid (prednisone treatment, but the dose was gradually reduced from 10 mg/day to 5 mg/day at 1 week after the patient’s symptoms disappeared. The mechanism responsible for the patient’s condition remains unclear.

  19. Chrysomelid males with enlarged mandibles: three new species and a review of occurrence in the family (Coleoptera: Chrysomelidae).

    Science.gov (United States)

    Reid, C A M; Beatson, M

    2013-01-01

    Three new species of Chrysomelidae with extraordinary extensions of the male mandibles are described: Scaphodius drehu sp. nov. and S. ferox sp. nov. (Cryptocephalinae), from New Caledonia, and Chaloenus gajah sp. nov. (Galerucinae), from Borneo. Designation of the type species of Chaloenus Westwood, 1861, is clarified. Synonymy of Scaphodius Chapuis, 1874, with Nyetra Baly, 1877, is supported. Four species of Ditropidus Erichson, 1842, described from New Caledonia, but hitherto regarded as nomina nuda, are shown to be available and are placed in Scaphodius: S. aeneus (Fauvel, 1907), comb. nov., S. nitidus (Fauvel, 1907) comb. nov., S. striolatus (Fauvel, 1907) comb. nov., S. sulcatus (Fauvel, 1907) comb. nov. Ditropidus opacicollis Fauvel, 1907, is also transferred to Scaphodius, as S. opacicollis (Fauvel) comb. nov. The genus Ditropidus does not occur on New Caledonia. Male mandible enlargment in the Chrysomelidae is reviewed: it is common in Cryptocephalinae, but otherwise restricted to a few species of Chrysomelinae, Eumolpinae and Galerucinae. Possible reasons for its distribution in the Chrysomelidae are discussed. PMID:26131467

  20. Board of Governors enlarged

    International Nuclear Information System (INIS)

    Professor Carlo Salvetti, of Italy, was elected Chairman by the Board of Governors of the International Atomic Energy Agency for 1963-64, when the new Board met for the first time on 2 October 1963. Professor Salvetti is Head of the Department of Nuclear Physics, University of Milan. He is also a member of the Executive Board of the Italian National Committee for Nuclear Energy (CNEN), President of the OECD Study Group on High Flux Reactors, and Italian Representative of the Working Group of the European Nuclear Energy Society. Formerly he was Director of the IAEA Division of Research. The election of seven new members at the seventh session of the General Conference in October 1963 increased the membership of the Board of Governors from 23 to 25. This resulted from a decision of the General Conference in 1961, designed to provide more equitable representation for Africa and the Middle East. The necessary amendment to the Agency's Statute came into force in January 1963, when the requisite number of instruments of acceptance had been deposited.

  1. Enlarged prostate - after care

    Science.gov (United States)

    BPH - self-care; Benign prostatic hypertrophy - self-care; Benign prostatic hyperplasia - self-care ... exercises ( Kegel exercises ) that strengthen the pelvic floor muscles. Doing these exercise may help with leaking or ...

  2. Penile Cancer Initially Presented with Enlarged Inguinal Lymph Nodes(Report of 6 Cases)%以腹股沟肿大淋巴结为首发表现的阴茎癌6例报告

    Institute of Scientific and Technical Information of China (English)

    朱耀; 叶定伟; 姚旭东; 张世林; 戴波; 张海梁; 沈益君

    2011-01-01

    目的:探讨以腹股沟肿大淋巴结为首发表现的阴茎痛的I临床特点及诊治方法.方法:本组患者6例,均因为肿大的腹股沟淋巴结初诊于外院,在我院经细胞穿刺学证实为鳞癌转移.全部患者均有包茎或包皮过长病史,在成年后接受过包皮环切手术.4例患者在阴茎包皮环切瘢痕处有小灶肿块或溃疡,广切后病理显示为阴茎鳞癌,2例患者既往环切术标本经病理复片后诊断为阴茎鳞癌.结果:阴茎癌原发灶病理分析显示4例为T1期病变,2例为T2期病变,临床病灶均较小,直径为5~10 mm.腹股沟肿大淋巴结直径最小4 cm.最大达9 cm且伴破溃.6例患者中4例先接受了手术治疗,2例接受了新辅助化疗后再次手术.术后淋巴结病理送检证实腹股沟淋巴结鳞癌累及,且均有淋巴结外癌侵犯.6例患者中有5例复发,仅1例无病存活26个月.结论:以腹股沟肿大淋巴结为首发表现的阴茎癌并不多见,但是初诊时往往被误诊为其他疾病而延误了及时治疗.提高此类患者治疗效果的关键在于早期准确诊断,需要进行腹股沟淋巴结的穿刺病理检查,细致的寻找原发病灶.%Objective:To evaluate the characteristics and outcome of penile cancer initially presented with enlarged inguinal lymph nodes. Methods:A total of 6 patients who were initially referred to other hospital with enlarged inguinal nodes were confirmed to have squamous cell carcinoma metastases in our center. All of them had a history of phimosis and underwent circumcision in adult. Four patients had small lesions in the scar of previous circumcision. Wide local excision showed squamous cell carcinoma in these patients. Two patients were diagnosed as penile cancer after pathological review of circumcision specimens. Results: The penile lesions were staged as T1 in 4 cases and T2 in 2 patient. The diameter of the primary tumor ranged from 5 to 10 mm, and the size of enlarged inguinal mass ranged

  3. Nest enlargement in leaf-cutting ants: relocated brood and fungus trigger the excavation of new chambers.

    Directory of Open Access Journals (Sweden)

    Daniela Römer

    Full Text Available During colony growth, leaf-cutting ants enlarge their nests by excavating tunnels and chambers housing their fungus gardens and brood. Workers are expected to excavate new nest chambers at locations across the soil profile that offer suitable environmental conditions for brood and fungus rearing. It is an open question whether new chambers are excavated in advance, or will emerge around brood or fungus initially relocated to a suitable site in a previously-excavated tunnel. In the laboratory, we investigated the mechanisms underlying the excavation of new nest chambers in the leaf-cutting ant Acromyrmex lundi. Specifically, we asked whether workers relocate brood and fungus to suitable nest locations, and to what extent the relocated items trigger the excavation of a nest chamber and influence its shape. When brood and fungus were exposed to unfavorable environmental conditions, either low temperatures or low humidity, both were relocated, but ants clearly preferred to relocate the brood first. Workers relocated fungus to places containing brood, demonstrating that subsequent fungus relocation spatially follows the brood deposition. In addition, more ants aggregated at sites containing brood. When presented with a choice between two otherwise identical digging sites, but one containing brood, ants' excavation activity was higher at this site, and the shape of the excavated cavity was more rounded and chamber-like. The presence of fungus also led to the excavation of rounder shapes, with higher excavation activity at the site that also contained brood. We argue that during colony growth, workers preferentially relocate brood to suitable locations along a tunnel, and that relocated brood spatially guides fungus relocation and leads to increased digging activity around them. We suggest that nest chambers are not excavated in advance, but emerge through a self-organized process resulting from the aggregation of workers and their density

  4. Comparison of the Relationship between Cerebral White Matter and Grey Matter in Normal Dogs and Dogs with Lateral Ventricular Enlargement.

    Directory of Open Access Journals (Sweden)

    Martin J Schmidt

    Full Text Available Large cerebral ventricles are a frequent finding in brains of dogs with brachycephalic skull conformation, in comparison with mesaticephalic dogs. It remains unclear whether oversized ventricles represent a normal variant or a pathological condition in brachycephalic dogs. There is a distinct relationship between white matter and grey matter in the cerebrum of all eutherian mammals. The aim of this study was to determine if this physiological proportion between white matter and grey matter of the forebrain still exists in brachycephalic dogs with oversized ventricles. The relative cerebral grey matter, white matter and cerebrospinal fluid volume in dogs were determined based on magnetic-resonance-imaging datasets using graphical software. In an analysis of covariance (ANCOVA using body mass as the covariate, the adjusted means of the brain tissue volumes of two groups of dogs were compared. Group 1 included 37 mesaticephalic dogs of different sizes with no apparent changes in brain morphology, and subjectively normal ventricle size. Group 2 included 35 brachycephalic dogs in which subjectively enlarged cerebral ventricles were noted as an incidental finding in their magnetic-resonance-imaging examination. Whereas no significant different adjusted means of the grey matter could be determined, the group of brachycephalic dogs had significantly larger adjusted means of lateral cerebral ventricles and significantly less adjusted means of relative white matter volume. This indicates that brachycephalic dogs with subjective ventriculomegaly have less white matter, as expected based on their body weight and cerebral volume. Our study suggests that ventriculomegaly in brachycephalic dogs is not a normal variant of ventricular volume. Based on the changes in the relative proportion of WM and CSF volume, and the unchanged GM proportions in dogs with ventriculomegaly, we rather suggest that distension of the lateral ventricles might be the underlying cause

  5. Comparison of the Relationship between Cerebral White Matter and Grey Matter in Normal Dogs and Dogs with Lateral Ventricular Enlargement.

    Science.gov (United States)

    Schmidt, Martin J; Laubner, Steffi; Kolecka, Malgorzata; Failing, Klaus; Moritz, Andreas; Kramer, Martin; Ondreka, Nele

    2015-01-01

    Large cerebral ventricles are a frequent finding in brains of dogs with brachycephalic skull conformation, in comparison with mesaticephalic dogs. It remains unclear whether oversized ventricles represent a normal variant or a pathological condition in brachycephalic dogs. There is a distinct relationship between white matter and grey matter in the cerebrum of all eutherian mammals. The aim of this study was to determine if this physiological proportion between white matter and grey matter of the forebrain still exists in brachycephalic dogs with oversized ventricles. The relative cerebral grey matter, white matter and cerebrospinal fluid volume in dogs were determined based on magnetic-resonance-imaging datasets using graphical software. In an analysis of covariance (ANCOVA) using body mass as the covariate, the adjusted means of the brain tissue volumes of two groups of dogs were compared. Group 1 included 37 mesaticephalic dogs of different sizes with no apparent changes in brain morphology, and subjectively normal ventricle size. Group 2 included 35 brachycephalic dogs in which subjectively enlarged cerebral ventricles were noted as an incidental finding in their magnetic-resonance-imaging examination. Whereas no significant different adjusted means of the grey matter could be determined, the group of brachycephalic dogs had significantly larger adjusted means of lateral cerebral ventricles and significantly less adjusted means of relative white matter volume. This indicates that brachycephalic dogs with subjective ventriculomegaly have less white matter, as expected based on their body weight and cerebral volume. Our study suggests that ventriculomegaly in brachycephalic dogs is not a normal variant of ventricular volume. Based on the changes in the relative proportion of WM and CSF volume, and the unchanged GM proportions in dogs with ventriculomegaly, we rather suggest that distension of the lateral ventricles might be the underlying cause of pressure

  6. Cavity as a source of conformational fluctuation and high-energy state: High-pressure NMR study of a cavity-enlarged mutant of T4 lysozyme

    CERN Document Server

    Maeno, Akihiro; Hirata, Fumio; Otten, Renee; Dahlquist, Frederick W; Yokoyama, Shigeyuki; Akasaka, Kazuyuki; Mulder, Frans A A; Kitahara, Ryo

    2014-01-01

    Although the structure, function, conformational dynamics, and controlled thermodynamics of proteins are manifested by their corresponding amino acid sequences, the natural rules for molecular design and their corresponding interplay remain obscure. In this study, we focused on the role of internal cavities of proteins in conformational dynamics. We investigated the pressure-induced responses from the cavity-enlarged L99A mutant of T4 lysozyme, using high-pressure NMR spectroscopy. The signal intensities of the methyl groups in the 1H/13C HSQC spectra, particularly those around the enlarged cavity, decreased with the increasing pressure, and disappeared at 200 MPa, without the appearance of new resonances, thus indicating the presence of heterogeneous conformations around the cavity within the ground state ensemble. Above 200 MPa, the signal intensities of more than 20 methyl groups gradually decreased with the increasing pressure, without the appearance of new resonances. Interestingly, these residues closel...

  7. A case report on the relationship between treatment-resistant childhood-onset schizophrenia and an abnormally enlarged cavum septum pellucidum combined with cavum vergae

    Institute of Scientific and Technical Information of China (English)

    LIAO Zheng-luan; HU Shao-hua; XU Yi

    2012-01-01

    The treatment of refractory schizophrenia has been a clinical challenge for most psychiatrists; the possible reasons include diagnostic errors,medical conditions and brain dysgenesis.Here,we described a patient with childhood-onset schizophrenia who had severe psychiatric symptoms such as auditory hallucinations and persecutory delusions,and etc.We reexamined all his possible medical conditions and found that the patient had an abnormally enlarged cavus septum pellucidum (CSP) combined with cavum vergae (CV) (maximum length >30 mm).Some reports suggested that abnormal CSP (length >6 mm) has a significant association with schizophrenia.However,abnormally large CSP or CSP/CV and related prognosis were reported rarely.This case suggested that abnormally enlarged CSP or CSP/CV may worsen the prognosis.

  8. Pneumocystis murina Infection and Cigarette Smoke Exposure Interact To Cause Increased Organism Burden, Development of Airspace Enlargement, and Pulmonary Inflammation in Mice▿

    OpenAIRE

    Christensen, Paul J; Preston, Angela M.; Ling, Tony; Du, Ming; Fields, W. Bradley; Curtis, Jeffrey L.; Beck, James M.

    2008-01-01

    Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow obstruction and lung destruction with airspace enlargement. In addition to cigarette smoking, respiratory pathogens play a role in pathogenesis, but specific organisms are not always identified. Recent reports demonstrate associations between the detection of Pneumocystis jirovecii DNA in lung specimens or respiratory secretions and the presence of emphysema in COPD patients. Additionally, human immunodef...

  9. Lack of significant association between mutations of KCNJ10 or FOXI1 and SLC26A4 mutations in pendred syndrome/enlarged vestibular aqueducts

    OpenAIRE

    Landa, P. (Přemysl); Differ, A. M.; Rajput, K.; Jenkins, L; Bitner-Glindzicz, M

    2013-01-01

    Background Pendred syndrome is a common autosomal recessive disorder causing deafness. Features include sensorineural hearing impairment, goitre, enlarged vestibular aqueducts (EVA) and occasionally Mondini dysplasia. Hearing impairment and EVA may occur in the absence of goitre or thyroid dyshormonogensis in a condition known as non-syndromic EVA. A significant number of patients with Pendred syndrome and non-syndromic EVA show only one mutation in SLC26A4. Two genes, KCNJ10, encoding an inw...

  10. The gauge freedoms of enlarged Helmholtz theorem and the Neumann-Debye potentials; Their manifestation in the multipole expansion of conserved current

    International Nuclear Information System (INIS)

    We discuss gauge freedom within the scope of the enlarged Helmholtz theorem and Neumann-Debye decomposition and then demonstrate its realization for the multipole expansion of a electromagnetic current with distinguished toroid moment family. The exact solution to the latter problem was obtained in 1974, but answers to some purely mathematical questions raised by I.B.French and Y.Shimamoto [1] about 40 years ago are given in this paper for the first time

  11. Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes

    OpenAIRE

    Varlamov, Oleg; Somwar, Romel; Cornea, Anda; Kievit, Paul; Grove, Kevin L.; Roberts, Charles T.

    2010-01-01

    Increased body fat correlates with the enlargement of average fat cell size and reduced adipose tissue insulin sensitivity. It is currently unclear whether adipocytes, as they accumulate more triglycerides and grow in size, gradually become less insulin sensitive or whether obesity-related factors independently cause both the enlargement of adipocyte size and reduced adipose tissue insulin sensitivity. In the first instance, large and small adipocytes in the same tissue would exhibit differen...

  12. Study on Anatomical Structure Characteristics of Zizyphus Jujuba'Jingzao39' in the Stage of Fruit Enlargement%'京枣39'果实膨大期解剖结构特性研究

    Institute of Scientific and Technical Information of China (English)

    潘青华; 李海龙; 张玉平

    2011-01-01

    为探讨枣果的裂果机理,笔者采用显微法对'京枣39'新品种不同位置果实处于膨大期时的角质层、表皮、亚表皮、中果皮、维管束和空腔等解剖结构及其变化规律进行了研究.结果表明:随着果实的逐渐发育成熟,枣果体积逐渐增大,角质层厚度、表皮厚度、亚表皮细胞大小、中果皮细胞大小和维管束粗细的变化趋势一致,均呈现出逐渐增大的趋势,空腔大小的变化趋势略有差异,呈现出"低-高-低"单峰变化.%To investigate the cracking mechanism of jujube fruit, the changes and the anatomical structures of Zizyphus Jujuba ' Jingzao39' fruit and the stage of enlargement in different locations including cuticle, epidermis, sub-epidermal cell, mesocarp cells, the vascular thickness and the size of cavity were studied by microscopy in this text.The results showed that jujube fruit increased in volume with the gradual development of mature fruit, the changing trends of the cuticle thickness, the epidermal thickness, the size of sub-epidermal cell,the size of mesocarp cell and the vascular thickness were consistent, showed a gradually increasing trend.The changing trends of the size of cavity was different, showed 'low-high-low' single-peak curve.

  13. Review of small hydropower in the new Member States and Candidate Countries in the context of the enlarged European Union

    Energy Technology Data Exchange (ETDEWEB)

    Punys, Petras [Lithuanian University of Agriculture, Water and Land Management Faculty, Universiteto 10, LT-5336, Kaunas-Akademija (Lithuania); Pelikan, Bernhard [University of Natural Resources and Applied Life Sciences, Institute of Water Management, Hydrology and Hydraulic Engineering, Muthgasse 18, A-1190 Vienna (Austria)

    2007-09-15

    are approximately 3200 plants installed in these countries, corresponding to a capacity of about 1430 MW of SHP. Conversely, a much larger number of SHP plants are installed in the EU-15 (some 14 000 with the total capacity of 10 000 MW). The average size of a SHP plant is about 0.44 MW (0.70 MW in EU-15). In almost all analyzed countries hydropower is a dominant source of energy in renewable electricity production. SHP is the second largest (after large hydro) contributor. The Czech Republic and Slovenia are the main countries with highest levels of turbine manufacturing industry. In some surveyed countries some opposition to SHP, mainly related to fish protection, visual impacts, enlargement of protected areas, has been identified. The current technical state of the SHP sector in the surveyed countries in terms of generating capacities and contribution to total electricity generation is relatively low by comparing with that of the former EU-15. Despite the fact that in the EU-10 and CC so far has been exploited just about 30% and 6% of economically feasible potential, they will never achieve the strength in terms of generating capacities of the SHP sector of the former EU-15 (more than 82% developed so far). The CC may slightly bridge this gap by harnessing their untapped SHP potential (especially in Turkey). A brief profile of SHP sector of the surveyed countries is provided at the end of the paper. (author)

  14. Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span

    OpenAIRE

    1994-01-01

    The yeast Saccharomyces cerevisiae typically divides asymmetrically to give a large mother cell and a smaller daughter cell. As mother cells become old, they enlarge and produce daughter cells that are larger than daughters derived from young mother cells. We found that occasional daughter cells were indistinguishable in size from their mothers, giving rise to a symmetric division. The frequency of symmetric divisions became greater as mother cells aged and reached a maximum occurrence of 30%...

  15. Elevated 68Ga Prostate-Specific Membrane Antigen Activity in Metastatic Non-Small Cell Lung Cancer.

    Science.gov (United States)

    Shetty, Deepa; Loh, Han; Bui, Chuong; Mansberg, Robert; Stevanovic, Amanda

    2016-05-01

    A 71-year-old man with a background of treated stage IIIB non-small cell lung cancer was referred for Ga prostate-specific membrane antigen (PSMA) PET/CT for staging of prostate cancer. In addition to the PSMA uptake in the known prostate malignancy, the study also demonstrated increased PSMA uptake in an enlarging left lower lobe lung mass with diffusely increased PSMA uptake in an enlarged thyroid gland and bilateral enlarged supraclavicular lymph nodes. Fine-needle aspiration biopsy of the thyroid gland and a left supraclavicular lymph node demonstrated metastatic adenocarcinoma from a primary lung cancer. PMID:26828144

  16. Megalophallus as a sequela of priapism in sickle cell anemia: use of blood oxygen level-dependent magnetic resonance imaging.

    Science.gov (United States)

    Kassim, A A; Umans, H; Nagel, R L; Fabry, M E

    2000-09-01

    Priapism is a common complication of sickle cell anemia. We report a little known sequela of priapism: painless megalophallus, with significant penile enlargement. The patient had had an intense episode of priapism 9 years previously and his penis remained enlarged. Blood oxygen level-dependent magnetic resonance imaging revealed enlarged, hypoxic corpora cavernosa. Megalophallus probably resulted from permanent loss of elasticity of the tunica albuginea due to severe engorgement during the episode of priapism. This sequela needs to be recognized by physicians because no intervention is necessary and sexual function seems to remain intact. PMID:10962334

  17. The Treaty of Nice and the Distribution of Votes in the Council Voting Power Consequences for the EU after the Oncoming Enlargement

    Directory of Open Access Journals (Sweden)

    Bela Plechanovová

    2003-05-01

    Full Text Available The IGC 2000 had the objective to prepare the European Union for the enlargement. The aim of the present paper is to evaluate the Nice solution of the Council's decision-making rules from the perspective of the decision on the number of candidate countries which should join the EU in 2004, as proposed by the Brussels European Council in October 2002 and approved by the Copenhagen European Council last December. The evaluation is based on the comparison of the Nice solution with all the relevant proposals, which were presented to the IGC 2000. The results bring an assessment of the voting power effect of both the Nice rules and the proposals. The reason for this comparison consists in the fact that these proposals represented the spectrum of approaches considered as plausible, during the last IGC and some of them much earlier. Since ten designated candidate countries should be regular participants of the next IGC and since these proposals might be picked up again if the question of decision-making rules in the Council is reopened by the next IGC, the question of respective voting power consequences of the proposals for the EU25 should be answered. The method used for evaluation of voting power consequences of individual solutions is based on the Banzhaf index. The comparison leads to the conclusions that the distribution of voting power in the Council after enlargement to 25 members will be more even in terms of equitable representation of population of the member countries than most of other solutions proposed to the IGC, but is far from optimal as it disadvantages a group of smaller members to a greater degree than it disadvantages the most populous countries. Another conclusion is that the population criterion will not influence the voting power of member states after oncoming enlargement and would not be effective in any other dual weighted majority solution.

  18. The effectiveness of iodine prophylaxis and frequency of thyroid enlargement (thyroid goiter) and clinical diagnosis of thyroid diseases in inhabitants of Szczecin's region after Chernobyl accident

    International Nuclear Information System (INIS)

    The study, supported by program MZ-17, was carried on 4567 inhabitants of the area of Szczecin (2350 females and 2217 males). The population was chosen randomly, according to a simple drawing scheme. All subjects were clinically examined using standardised questionnaires. In 3468 persons (including 1807 girls and women, 1661 boys and men) apart form clinical examination, the assessment of thyrotropin, thyroxine and triiodothyronine in serum and frequency of anti thyroglobulin antibodies and antithyroid membrane and antithyroid membrane antibodies were evaluated. The data indicate that 94% of children in Szczecin's region received the prophylactic dose of iodine, mostly between the 1st and 5th of May 1986. Only 17% of the adults received iodine. The most common preparation was Lugol solution given in a single dose. Among all persons who received iodine, only in 5% of subjects the side effects were noted (mostly in children), including symptoms of gastrointestinal tract (vomiting, abdomen pain) and occasionally intra thyroid side effects (thyroid pains). In examined population the high frequency of thyroid enlargement, mainly in women (up to 43-44% at the age group 30-50 years) was found. The frequency of thyroid enlargement, mainly in women (up to 43-44% at the age group 30-50 years) was found. The frequency of clinical diagnosis of thyroid disease was higher in woman than in man (most of the diffuse goiter, rarely the nodular goiter). The frequency of thyroid enlargement and clinical diagnosis of thyroid disease was not dependent on prophylactic iodine intake. The iodine prophylaxis did not influence on thyroid hormones and TSH serum levels and in frequency of antithyroid antibodies. (author). 1 ref, 6 tabs

  19. Effect of liquid-phase surface tension on hydrodynamics of a three-phase airlift reactor with an enlarged degassing zone

    OpenAIRE

    Freitas, Carla Maria Duarte de; Teixeira, J.A.

    1998-01-01

    The effect of the addition of ethanol (10 g/l) to the liquid-phase on gas and solids holdup, circulation and mixing times and interstitial liquid velocity in a threephase airlift reactor was investigated. The airlift reactor (60 l) is of the concentric draught-tube type with an enlarged degassing zone. Ca-alginate beads were used as solid-phase and airflow rate (from 1.9 to 90.2 l/min) and solids loading (0-30% (v/v)) were manipulated. Riser and downcomer gas holdup we...

  20. Screening for acromegaly by application of a simple questionnaire evaluating the enlargement of extremities in adult patients seen at primary health care units.

    Science.gov (United States)

    Rosario, Pedro Weslley; Calsolari, Maria Regina

    2012-06-01

    The objective of this study was to screen for acromegaly by application of a simple questionnaire in patients seen at primary health care units. A total of 17,000 patients of both genders >18 and physiognomy (confirmed by the comparison of photographs), in addition to the enlargement of extremities. The present investigation suggests a much higher prevalence of acromegaly in the adult population than that reported traditionally. We propose that screening based on phenotypic alterations is cost-effective since these changes occur early and almost universally in acromegaly and are uncommon in the general population. PMID:21380935

  1. Gingival enlargement as an early diagnostic indicator in therapy-related acute myeloid leukemia: A rare case report and review of literature

    Directory of Open Access Journals (Sweden)

    Triveni M Gowda

    2013-01-01

    Full Text Available Treatment for Hodgkin′s lymphoma (HL has resulted in excellent survival rates but is associated with increased risks of secondary therapy-related acute myeloid leukemia (t-AML. Gingival enlargement associated with bleeding and ulceration is the most common rapidly appearing oral manifestations of leukemic involvement. An 8 months pregnant patient reported with generalized gingival enlargement, with localized cyanotic and necrotic papillary areas. Co-relating the hematological report with the oral lesions and her past medical history of HL, a diagnosis of t-AML secondary to treatment for HL was made by the oncologist. As oral lesions are one of the initial manifestations of acute leukemia, they may serve as a significant diagnostic indicator for the dental surgeons and their important role in diagnosing and treating such cases. Furthermore, this case report highlights the serious complication of t-AML subsequent to HL treatment and the important role that a general and oral health care professional may play in diagnosing and treating such cases.

  2. Planning Method of Eco-environment Restoration Based on Enlarging Terrace and De-farming in Loess Hilly Region——A Case Study of Yangou Catchment

    Institute of Scientific and Technical Information of China (English)

    Lijuan; DANG; Yong; XU

    2013-01-01

    After expatiating the guiding ideology,contents,standards and principles of eco-environment restoration based on enlarging terrace and de-farming,this paper discussed the planning method and technical flow of enlarging terrace and garden plot in a small catchment of loess hilly region by means of GIS spatial analysis technology,and then the planning method was applied in Yangou catchment.The result showed that it is practicabl,and the areas of newly-built terrace and garden plot in Yangou catchment are at least 295.06 and 4.61 hm2,so that the areas of basic farmland and garden plot reach 359.23 and 622.69 hm2.After the land use structure is regulated,the forest coverage is 48.87%,and the permanent vegetation coverage is about 75% in Yangou catchment,while sediment reduction benefit is above 80% in slope land.In agricultural development,Yangou catchment can yield 1 645.13 tons of food supplies,above 9 340 tons of apples,and can feed 7 500 sheep every year.

  3. Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature

    OpenAIRE

    Knez, Virginia M; Barrow, Willis; Lucia, M. Scott; Wilson, Shandra; La Rosa, Francisco G.

    2014-01-01

    Introduction The occurrence of clear cell tumors in the bladder is not uncommon. Clear cell dysplasia is well-described and characterized by focal replacement of transitional mucosa by cells with abundant clear cytoplasm, nuclear enlargement, and a granular chromatin pattern. Clear cells can also be seen in clear cell adenocarcinoma, which is rare, comprising 0.5% to 2.0% of the reported bladder carcinomas. Other clear cell tumors found in the bladder to be considered in the differential diag...

  4. Endolymphatic Sac Enlargement in a Girl with a Novel Mutation for Distal Renal Tubular Acidosis and Severe Deafness

    OpenAIRE

    Rink Nikki; Bitzan Martin; O'Gorman Gus; Nagel Mato; Torban Elena; Goodyer Paul

    2012-01-01

    Hereditary distal renal tubular acidosis (dRTA) is caused by mutations of genes encoding subunits of the H+-ATPase (ATP6V0A4 and ATP6V1B1) expressed in α -intercalated cells of the distal renal tubule and in the cochlea. We report on a 2-year-old girl with distal RTA and profound speech delay which was initially misdiagnosed as autism. Genetic analysis showed compound heterozygous mutations with one known and one novel mutation of the ATP6V1B1 gene; cerebral magnetic resonance imaging (MRI) r...

  5. Overexpression of a New Putative Membrane Protein Gene AtMRB1 Results in Organ Size Enlargement in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    Hua Guan; Dingming Kang; Min Fan; Zhangliang Chen; LiJia Qu

    2009-01-01

    Arabidopsis AtMRB1 is predicted to encode a novel protein of 432 amino acid residues in length, with four putative trans-membrane domains. In the present study, characterization of AtMRB1 is conducted. Green fluorescent protein (GFP) fusion protein assay showed that AtMRB1 was located in the plasma membrane. Transgenic lines overexprsssing AtMRB1 driven by a CaMV 35S promoter were generated. Statistic analysis showed that, during the seedling stage, the organ sizes of the transgenic lines including hypocotyl length, root length and root weight were significantly larger than those of the wild type plants under both light and dark conditions. In the adult plant stage, the AtMRB1 overexpressor plants were found to have larger organ sizes in terms of leaf length and width, and increased number of cauline leaves and branches when bolting. Further observation indicated that the larger leaf size phenotype was due to a larger number of mesophyll cells, the size of which was not altered. Quantitative real-time polymerase chain reaction analysis showed that the transcription of ANT, ROT3 and GRF5 were upregulated in the AtMRB1-overexpressor plants. These data suggest that AtMRB1 is possibly a positive regulator of organ size development in Arabidopsis, mainly through cell number control.

  6. Magnetic field induced enlargement of the regime of critical fluctuations in the classical superconductor V3Si from high-resolution specific heat experiments.

    Science.gov (United States)

    Zheng, Y; Liu, Y; Toyota, N; Lortz, R

    2015-02-25

    We present high-resolution specific heat data from a high-purity single crystal of the classical superconductor V(3)Si, which reveal tiny lambda-shape anomalies at the superconducting transition superimposed onto the BCS specific heat jump in magnetic fields of 2 T and higher. The appearance of these anomalies is accompanied by a magnetic-field-induced broadening of the superconducting transition. We demonstrate, using scaling relations predicted by the fluctuation models of the 3d-XY and the 3d-lowest-Landau-level (3d-LLL) universality class that the effect of critical fluctuations becomes experimentally observable due to of a magnetic field-induced enlargement of the regime of critical fluctuations. The scaling indicates that a reduction of the effective dimensionality due to the confinement of quasiparticles into low Landau levels is responsible for this effect. PMID:25640214

  7. Ultrasound for critical care physicians: sickle cell crisis

    Directory of Open Access Journals (Sweden)

    Raschke RA

    2013-08-01

    Full Text Available No abstract available. Article truncated after first page. A 32 year old man was admitted a week earlier with sickle cell pain crisis. He had developed increasing dyspnea, oxygen desaturation and bilateral pulmonary infiltrates. He had a pulseless electric activity code blue and an ultrasound of the heart was obtained (Figure 1. Figure 1. Subxiphoid view ultrasound of the heart. What does the ultrasound show? 1. Aortic dissection; 2. Aortic stenosis; 3. Enlarged left ventricle; 4. Enlarged right ventricle; 5. Pericardial effusion

  8. Cavitary Lung Cancer Lined with Normal Bronchial Epithelium and Cancer Cells

    OpenAIRE

    Goto, Taichiro; Maeshima, Arafumi; Oyamada, Yoshitaka; Kato, Ryoichi

    2011-01-01

    Reports of cavitary lung cancer are not uncommon, and the cavity generally contains either dilated bronchi or cancer cells. Recently, we encountered a surgical case of cavitary lung cancer whose cavity tended to enlarge during long-term follow-up, and was found to be lined with normal bronchial epithelium and adenocarcinoma cells.

  9. Chronic Treatment With an Erythropoietin Receptor Ligand Prevents Chronic Kidney Disease-Induced Enlargement of Myocardial Infarct Size.

    Science.gov (United States)

    Nishizawa, Keitaro; Yano, Toshiyuki; Tanno, Masaya; Miki, Takayuki; Kuno, Atsushi; Tobisawa, Toshiyuki; Ogasawara, Makoto; Muratsubaki, Shingo; Ohno, Kouhei; Ishikawa, Satoko; Miura, Tetsuji

    2016-09-01

    Chronic kidney disease (CKD) is known to increase myocardial infarct size after ischemia/reperfusion. However, a strategy to prevent the CKD-induced myocardial susceptibility to ischemia/reperfusion injury has not been developed. Here, we examined whether epoetin β pegol, a continuous erythropoietin receptor activator (CERA), normalizes myocardial susceptibility to ischemia/reperfusion injury by its effects on protective signaling and metabolomes in CKD. CKD was induced by 5/6 nephrectomy in rats (subtotal nephrectomy, SNx), whereas sham-operated rats served controls (Sham). Infarct size as percentage of area at risk after 20-minutes coronary occlusion/2-hour reperfusion was larger in SNx than in Sham: 60.0±4.0% versus 43.9±2.2%. Administration of CERA (0.6 μg/kg SC every 7 days) for 4 weeks reduced infarct size in SNx (infarct size as percentage of area at risk=36.9±3.9%), although a protective effect was not detected for the acute injection of CERA. Immunoblot analyses revealed that myocardial phospho-Akt-Ser473 levels under baseline conditions and on reperfusion were lower in SNx than in Sham, and CERA restored the Akt phosphorylation on reperfusion. Metabolomic analyses showed that glucose 6-phosphate and glucose 1-phosphate were reduced and malate:aspartate ratio was 1.6-fold higher in SNx than in Sham, suggesting disturbed flux of malate-aspartate shuttle by CKD. The CERA improved the malate:aspartate ratio in SNx to the control level. In H9c2 cells, mitochondrial Akt phosphorylation by insulin-like growth factor-1 was attenuated by malate-aspartate shuttle inhibition. In conclusion, the results suggest that a CERA prevents CKD-induced susceptibility of the myocardium to ischemia/reperfusion injury by restoration of Akt-mediated signaling possibly via normalized malate-aspartate shuttle flux. PMID:27456523

  10. Does ploidy level directly control cell size? Counterevidence from Arabidopsis genetics.

    Directory of Open Access Journals (Sweden)

    Hirokazu Tsukaya

    Full Text Available Ploidy level affects cell size in many organisms, and ploidy-dependent cell enlargement has been used to breed many useful organisms. However, how polyploidy affects cell size remains unknown. Previous studies have explored changes in transcriptome data caused by polyploidy, but have not been successful. The most naïve theory explaining ploidy-dependent cell enlargement is that increases in gene copy number increase the amount of protein, which in turn increases the cell volume. This hypothesis can be evaluated by examining whether any strains, mutants, or transgenics show the same cell size before and after a tetraploidization event. I performed this experiment by tetraploidizing various mutants and transgenics of Arabidopsis thaliana, which show a wide range in cell size, and found that the ploidy-dependent increase in cell volume is genetically regulated. This result is not in agreement with the theory described above.

  11. The Analysis of the Whole-scale "Well-off" Society and Enlarging the Capacity of Employment of the Tertial Industry%全面小康社会与扩大第三产业就业容量研究

    Institute of Scientific and Technical Information of China (English)

    李美云

    2003-01-01

    Building up a well-off society of a higher standard in an all-round way need enlarging the tertiary industry' s employment capacity, but how to enlarge its employment capacity ? Based on the present situation of China's employment, the problem in the tertiary industry's employment and the relationship between the output value and employment of the tertiary industry were analyzed, then some countermeasures about enlarging the tertiary industry's employment capacity in China were put forward in this paper.

  12. An unusual clinical presentation of plasma cell gingivitis related to "Acacia" containing herbal toothpaste.

    Science.gov (United States)

    Makkar, Anjali; Tewari, Shikha; Kishor, Kamal; Kataria, Santprakash

    2013-07-01

    A 17-year-old female patient presented with unusual enlargement of the gingiva with generalized alveolar bone loss. In spite of periodontal therapy, including plaque control, scaling, root planning and surgical treatment, recurrence with the same degree of the gingival enlargement and further loss of attachment level occurred. Biopsy revealed dense infiltration of normal plasma cells separated by collagenous stroma. Discontinuation of herbal toothpaste resulted in remarkable remission of the gingival enlargement within 2 weeks. Enzyme-linked immunosorbent assay of toothpaste components disclosed "Acacia" as an etiologic antigenic agent and confirmed the diagnosis of plasma cell gingivitis (PCG). Usually, PCG is not associated with the loss of attachment. This case report appears to be the first publication to document an atypical presentation of PCG with generalized aggressive periodontitis related to the use of herbal toothpaste containing "Acacia" extract from the tree "Acacia Arabica." PMID:24174738

  13. An unusual clinical presentation of plasma cell gingivitis related to "Acacia" containing herbal toothpaste

    Directory of Open Access Journals (Sweden)

    Anjali Makkar

    2013-01-01

    Full Text Available A 17-year-old female patient presented with unusual enlargement of the gingiva with generalized alveolar bone loss. In spite of periodontal therapy, including plaque control, scaling, root planning and surgical treatment, recurrence with the same degree of the gingival enlargement and further loss of attachment level occurred. Biopsy revealed dense infiltration of normal plasma cells separated by collagenous stroma. Discontinuation of herbal toothpaste resulted in remarkable remission of the gingival enlargement within 2 weeks. Enzyme-linked immunosorbent assay of toothpaste components disclosed " Acacia" as an etiologic antigenic agent and confirmed the diagnosis of plasma cell gingivitis (PCG. Usually, PCG is not associated with the loss of attachment. This case report appears to be the first publication to document an atypical presentation of PCG with generalized aggressive periodontitis related to the use of herbal toothpaste containing " Acacia" extract from the tree "Acacia Arabica."

  14. Omnidirectional photonic band gap enlarged by one-dimensional ternary unmagnetized plasma photonic crystals based on a new Fibonacci quasiperiodic structure

    International Nuclear Information System (INIS)

    In this paper, an omnidirectional photonic band gap realized by one-dimensional ternary unmagnetized plasma photonic crystals based on a new Fibonacci quasiperiodic structure, which is composed of homogeneous unmagnetized plasma and two kinds of isotropic dielectric, is theoretically studied by the transfer matrix method. It has been shown that such an omnidirectional photonic band gap originates from Bragg gap in contrast to zero-n gap or single negative (negative permittivity or negative permeability) gap, and it is insensitive to the incidence angle and the polarization of electromagnetic wave. From the numerical results, the frequency range and central frequency of omnidirectional photonic band gap can be tuned by the thickness and density of the plasma but cease to change with increasing Fibonacci order. The bandwidth of omnidirectional photonic band gap can be notably enlarged. Moreover, the plasma collision frequency has no effect on the bandwidth of omnidirectional photonic band gap. It is shown that such new structure Fibonacci quasiperiodic one-dimensional ternary plasma photonic crystals have a superior feature in the enhancement of frequency range of omnidirectional photonic band gap compared with the conventional ternary and conventional Fibonacci quasiperiodic ternary plasma photonic crystals.

  15. Autoimmune Pancreatitis Presenting a Short Narrowing of Main Pancreatic Duct with Subsequent Progression to Diffuse Pancreatic Enlargement over 24 Months; Natural History of Autoimmune Pancreatitis

    Directory of Open Access Journals (Sweden)

    Shuichiro Umemura

    2014-05-01

    Full Text Available Context Initial pancreatogram and natural history of autoimmune pancreatitis (AIP have not been clarified, and there were few recent studies concerning the association between AIP and intraductal papillary mucinous neoplasm (IPMN. Case report We report an 81-yearold man with AIP associated with IPMN. Although the initial pancreatogram was normal, a short narrowing of the main pancreatic duct (MPD appeared during a follow-up for IPMN after 6 months, which was highly suggestive of pancreatic cancer. A narrowing of the MPD extended after 15 months, and this progressed to diffuse narrowing of the MPD with an elevation in the serum IgG4 levels after 24 months. Finally, the patient was diagnosed with diffuse-type AIP, according to the Japanese diagnostic criteria 2011 and the International Consensus Diagnostic Criteria. Considering the natural history of AIP, this marked change of the MPD is indicative of this condition. Conclusion Wereport a case of AIP presenting with a short narrowing of the MPD with subsequent progression to diffuse pancreatic enlargement during a follow-up for IPMN.

  16. Omnidirectional photonic band gap enlarged by one-dimensional ternary unmagnetized plasma photonic crystals based on a new Fibonacci quasiperiodic structure

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Haifeng [College of Electronic and Information Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Nanjing Artillery Academy, Nanjing 211132 (China); Liu Shaobin [College of Electronic and Information Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); State Key Laboratory of Millimeter Waves of Southeast University, Nanjing Jiangsu 210096 (China); Kong Xiangkun; Bian Borui; Dai Yi [College of Electronic and Information Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China)

    2012-11-15

    In this paper, an omnidirectional photonic band gap realized by one-dimensional ternary unmagnetized plasma photonic crystals based on a new Fibonacci quasiperiodic structure, which is composed of homogeneous unmagnetized plasma and two kinds of isotropic dielectric, is theoretically studied by the transfer matrix method. It has been shown that such an omnidirectional photonic band gap originates from Bragg gap in contrast to zero-n gap or single negative (negative permittivity or negative permeability) gap, and it is insensitive to the incidence angle and the polarization of electromagnetic wave. From the numerical results, the frequency range and central frequency of omnidirectional photonic band gap can be tuned by the thickness and density of the plasma but cease to change with increasing Fibonacci order. The bandwidth of omnidirectional photonic band gap can be notably enlarged. Moreover, the plasma collision frequency has no effect on the bandwidth of omnidirectional photonic band gap. It is shown that such new structure Fibonacci quasiperiodic one-dimensional ternary plasma photonic crystals have a superior feature in the enhancement of frequency range of omnidirectional photonic band gap compared with the conventional ternary and conventional Fibonacci quasiperiodic ternary plasma photonic crystals.

  17. Patient mobility in the context of austerity and an enlarged EU: The European Court of Justice's ruling in the Petru Case.

    Science.gov (United States)

    Frischhut, Markus; Levaggi, Rosella

    2015-10-01

    Since 1998, the European Court of Justice (EUCJ) has established a set of principles concerning patient mobility across Member States. At present, these principles are challenged against a new background, i.e., an enlarged EU and austerity-driven measures in the field of healthcare. This is even more relevant in view of the significant differences between countries and between services on healthcare access. In the Petru case, a Romanian woman sought healthcare in Germany due to an alleged lack of basic infrastructure in her local Romanian hospital. A crucial question arises in this context of whether the patient's interests (i.e., right to cross-border healthcare) or the Member State's interests (i.e., financial stability of the healthcare system) prevail. We analyse this case and its implications for future patient mobility. From the point of view of patients, the EUCJ's decision implies that also a lack of medication and basic medical supplies can be claimed as "undue delay", however for Member States it is sufficient to provide quality treatments in at least one hospital. Although the Court has provided a solution for the Petru case, we argue that major challenges remain, such as the definition of the international state-of-the-art or other limitations to reductions of the health basket. PMID:26208965

  18. How to Enlarge Productive Vocabulary

    Institute of Scientific and Technical Information of China (English)

    刘菁

    2015-01-01

    Haycraft defined receptive vocabulary as "words that the student recognizes and understands when they occur in a text, but which he cannot produce correctly", while productive vocabulary is "words which the student understands can pronounce correctly and use constructively in speaking and writing" (1978:44).In English language teaching practice, students' productive vocabulary size lags far behind there ceptive vocabulary size. Based on the SLA theories, many reasons caused this problem and some solutions will be discussed.

  19. Economic elites in enlarged Europe

    OpenAIRE

    Bluhm, Katharina; Trappmann, Vera

    2008-01-01

    The introduction to the Special Issue on economic elites in Central Eastern Europe establishes a common understanding of elite research and the development of capitalism in Central Eastern Europe as developed during the 1990s. Since then, the composition of elites has been lost sight of by research. The article identifies areas which future research should look into and situates the German case in the broader debate.

  20. The laws. 4. enlarged ed.

    International Nuclear Information System (INIS)

    This issue no. 10 presents the terms and definitions valid in the field of civil defence, and the laws and regulations. There is the law relating to civil defence, of August 9, 1976, the official announcement, and the statement of legislative intent; further, the law relating to an extension of disaster services, together with the general administrative provisions concerning organisation, additional equipment, training of personnel, and financing of disaster services. The issue also presents the general administrative regulation for establishment, support, and management of civil defence, the law concerning construction and provision of shelters for the population, the general administrative regulation concerning local alarm systems and services (Warndienst-VwV) of March 31, 1981, and the act relating to the convention of May 14, 1954, for protection of cultural objects in the event of an armed conflict, (act of April 11, 1967), as well as the text of the convention itself and the protocol. (orig.)