WorldWideScience

Sample records for cell development program

  1. Programmed Cell Death During Caenorhabditis elegans Development.

    Science.gov (United States)

    Conradt, Barbara; Wu, Yi-Chun; Xue, Ding

    2016-08-01

    Programmed cell death is an integral component of Caenorhabditis elegans development. Genetic and reverse genetic studies in C. elegans have led to the identification of many genes and conserved cell death pathways that are important for the specification of which cells should live or die, the activation of the suicide program, and the dismantling and removal of dying cells. Molecular, cell biological, and biochemical studies have revealed the underlying mechanisms that control these three phases of programmed cell death. In particular, the interplay of transcriptional regulatory cascades and networks involving multiple transcriptional regulators is crucial in activating the expression of the key death-inducing gene egl-1 and, in some cases, the ced-3 gene in cells destined to die. A protein interaction cascade involving EGL-1, CED-9, CED-4, and CED-3 results in the activation of the key cell death protease CED-3, which is tightly controlled by multiple positive and negative regulators. The activation of the CED-3 caspase then initiates the cell disassembly process by cleaving and activating or inactivating crucial CED-3 substrates; leading to activation of multiple cell death execution events, including nuclear DNA fragmentation, mitochondrial elimination, phosphatidylserine externalization, inactivation of survival signals, and clearance of apoptotic cells. Further studies of programmed cell death in C. elegans will continue to advance our understanding of how programmed cell death is regulated, activated, and executed in general. Copyright © 2016 by the Genetics Society of America.

  2. Programmed cell death during quinoa perisperm development.

    Science.gov (United States)

    López-Fernández, María Paula; Maldonado, Sara

    2013-08-01

    At seed maturity, quinoa (Chenopodium quinoa Willd.) perisperm consists of uniform, non-living, thin-walled cells full of starch grains. The objective of the present study was to study quinoa perisperm development and describe the programme of cell death that affects the entire tissue. A number of parameters typically measured during programmed cell death (PCD), such as cellular morphological changes in nuclei and cytoplasm, endoreduplication, DNA fragmentation, and the participation of nucleases and caspase-like proteases in nucleus dismantling, were evaluated; morphological changes in cytoplasm included subcellular aspects related to starch accumulation. This study proved that, following fertilization, the perisperm of quinoa simultaneously accumulates storage reserves and degenerates, both processes mediated by a programme of developmentally controlled cell death. The novel findings regarding perisperm development provide a starting point for further research in the Amaranthaceae genera, such as comparing seeds with and without perisperm, and specifying phylogeny and evolution within this taxon. Wherever possible and appropriate, differences between quinoa perisperm and grass starchy endosperm--a morphologically and functionally similar, although genetically different tissue--were highlighted and discussed.

  3. Programmed cell senescence during mammalian embryonic development.

    Science.gov (United States)

    Muñoz-Espín, Daniel; Cañamero, Marta; Maraver, Antonio; Gómez-López, Gonzalo; Contreras, Julio; Murillo-Cuesta, Silvia; Rodríguez-Baeza, Alfonso; Varela-Nieto, Isabel; Ruberte, Jesús; Collado, Manuel; Serrano, Manuel

    2013-11-21

    Cellular senescence disables proliferation in damaged cells, and it is relevant for cancer and aging. Here, we show that senescence occurs during mammalian embryonic development at multiple locations, including the mesonephros and the endolymphatic sac of the inner ear, which we have analyzed in detail. Mechanistically, senescence in both structures is strictly dependent on p21, but independent of DNA damage, p53, or other cell-cycle inhibitors, and it is regulated by the TGF-β/SMAD and PI3K/FOXO pathways. Developmentally programmed senescence is followed by macrophage infiltration, clearance of senescent cells, and tissue remodeling. Loss of senescence due to the absence of p21 is partially compensated by apoptosis but still results in detectable developmental abnormalities. Importantly, the mesonephros and endolymphatic sac of human embryos also show evidence of senescence. We conclude that the role of developmentally programmed senescence is to promote tissue remodeling and propose that this is the evolutionary origin of damage-induced senescence. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. Workshop on programming beta cell development, impairment and regeneration

    DEFF Research Database (Denmark)

    Heller, Scott; Nielsen, Jens Høiriis

    2012-01-01

    (2003), El Perello, Spain (2006) and Peebles, Scotland (2009). The meeting drew 190 attendees from 12 different countries. There were 37 main oral presentations, and 68 posters covered virtually all aspects of the pancreas and provided a dynamic snapshot of the most interesting areas of current...... investigation. In addition, six parallel workshops on stem cells, epigenetics, autoimmunity, β-cell imaging, β-cell identity, omics in β-cell research and a panel discussion on "to be or not to be a beta cell" were held. Here, we will review some of the newest highlights and still unanswered questions...

  5. Programmed cell death

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The purpose of this conference to provide a multidisciplinary forum for exchange of state-of-the-art information on the role programmed cell death plays in normal development and homeostasis of many organisms. This volume contains abstracts of papers in the following areas: invertebrate development; immunology/neurology; bcl-2 family; biochemistry; programmed cell death in viruses; oncogenesis; vertebrate development; and diseases.

  6. NASA's PEM Fuel Cell Power Plant Development Program for Space Applications

    Science.gov (United States)

    Hoberecht, Mark A.

    2008-01-01

    A three-center NASA team led by the Glenn Research Center in Cleveland, Ohio is completing a five-year PEM fuel cell power plant development program for future space applications. The focus of the program has been to adapt commercial PEM fuel cell technology for space applications by addressing the key mission requirements of using pure oxygen as an oxidant and operating in a multi-gravity environment. Competing vendors developed breadboard units in the 1 to 5 kW power range during the first phase of the program, and a single vendor developed a nominal 10-kW engineering model power pant during the second phase of the program. Successful performance and environmental tests conducted by NASA established confidence that PEM fuel cell technology will be ready to meet the electrical power needs of future space missions.

  7. Clinical research skills development program in cell-based regenerative medicine.

    Science.gov (United States)

    Schulman, Ivonne Hernandez; Suncion, Viky; Karantalis, Vasileios; Balkan, Wayne; Hare, Joshua M

    2015-02-01

    Cell-based therapy aimed at restoring organ function is one of the most exciting and promising areas of medical research. However, a novel intervention like cell-based therapy requires physician education and training. An increasing number of physicians untrained in regenerative medicine are using cell-based therapy to treat patients for a wide variety of chronic illnesses. The current lack of training for physicians in this area combined with the sharply increasing practice of regenerative medicine is concerning for a number of reasons, namely potential harm to patients and avoidable conflicts between governmental regulatory agencies and physicians. Academic medical fellowship training programs are needed that specifically prepare physicians for treating patients with cell-based therapies for various organ systems and chronic diseases. The National Heart, Lung, and Blood Institute established the Cardiovascular Cell Therapy Network to design and conduct clinical trials that advance the field of cell-based therapy for patients with cardiovascular disease. As part of the network, a two-year Clinical Research Skills Development Program was supported at two centers with the goal of training early career investigators in cell-based clinical and translational research. In this review, we describe the implementation of this training program at our institution with the purpose of promoting the further development of academic fellowship programs in cell-based regenerative medicine. ©AlphaMed Press.

  8. DCD – a novel plant specific domain in proteins involved in development and programmed cell death

    Directory of Open Access Journals (Sweden)

    Doerks Tobias

    2005-07-01

    Full Text Available Abstract Background Recognition of microbial pathogens by plants triggers the hypersensitive reaction, a common form of programmed cell death in plants. These dying cells generate signals that activate the plant immune system and alarm the neighboring cells as well as the whole plant to activate defense responses to limit the spread of the pathogen. The molecular mechanisms behind the hypersensitive reaction are largely unknown except for the recognition process of pathogens. We delineate the NRP-gene in soybean, which is specifically induced during this programmed cell death and contains a novel protein domain, which is commonly found in different plant proteins. Results The sequence analysis of the protein, encoded by the NRP-gene from soybean, led to the identification of a novel domain, which we named DCD, because it is found in plant proteins involved in development and cell death. The domain is shared by several proteins in the Arabidopsis and the rice genomes, which otherwise show a different protein architecture. Biological studies indicate a role of these proteins in phytohormone response, embryo development and programmed cell by pathogens or ozone. Conclusion It is tempting to speculate, that the DCD domain mediates signaling in plant development and programmed cell death and could thus be used to identify interacting proteins to gain further molecular insights into these processes.

  9. Programmed cell death during development of cowpea (Vigna unguiculata (L.) Walp.) seed coat.

    Science.gov (United States)

    Lima, Nathália Bastos; Trindade, Fernanda Gomes; da Cunha, Maura; Oliveira, Antônia Elenir Amâncio; Topping, Jennifer; Lindsey, Keith; Fernandes, Kátia Valevski Sales

    2015-04-01

    The seed coat develops primarily from maternal tissues and comprises multiple cell layers at maturity, providing a metabolically dynamic interface between the developing embryo and the environment during embryogenesis, dormancy and germination of seeds. Seed coat development involves dramatic cellular changes, and the aim of this research was to investigate the role of programmed cell death (PCD) events during the development of seed coats of cowpea [Vigna unguiculata (L.) Walp.]. We demonstrate that cells of the developing cowpea seed coats undergo a programme of autolytic cell death, detected as cellular morphological changes in nuclei, mitochondria, chloroplasts and vacuoles, DNA fragmentation and oligonucleosome accumulation in the cytoplasm, and loss of membrane viability. We show for the first time that classes 6 and 8 caspase-like enzymes are active during seed coat development, and that these activities may be compartmentalized by translocation between vacuoles and cytoplasm during PCD events. © 2014 John Wiley & Sons Ltd.

  10. Fuel Cell Development for NASA's Human Exploration Program: Benchmarking with "The Hydrogen Economy"

    Science.gov (United States)

    Scott, John H.

    2007-01-01

    The theoretically high efficiency and low temperature operation of hydrogen-oxygen fuel cells has motivated them to be the subject of much study since their invention in the 19th Century, but their relatively high life cycle costs kept them as a "solution in search of a problem" for many years. The first problem for which fuel cells presented a truly cost effective solution was that of providing a power source for NASA's human spaceflight vehicles in the 1960 s. NASA thus invested, and continues to invest, in the development of fuel cell power plants for this application. This development program continues to place its highest priorities on requirements for minimum system mass and maximum durability and reliability. These priorities drive fuel cell power plant design decisions at all levels, even that of catalyst support. However, since the mid-1990's, prospective environmental regulations have driven increased governmental and industrial interest in "green power" and the "Hydrogen Economy." This has in turn stimulated greatly increased investment in fuel cell development for a variety of commercial applications. This investment is bringing about notable advances in fuel cell technology, but, as these development efforts place their highest priority on requirements for minimum life cycle cost and field safety, these advances are yielding design solutions quite different at almost every level from those needed for spacecraft applications. This environment thus presents both opportunities and challenges for NASA's Human Exploration Program

  11. Cell cycle regulation and cytoskeletal remodelling are critical processes in the nutritional programming of embryonic development.

    Science.gov (United States)

    Swali, Angelina; McMullen, Sarah; Hayes, Helen; Gambling, Lorraine; McArdle, Harry J; Langley-Evans, Simon C

    2011-01-01

    Many mechanisms purport to explain how nutritional signals during early development are manifested as disease in the adult offspring. While these describe processes leading from nutritional insult to development of the actual pathology, the initial underlying cause of the programming effect remains elusive. To establish the primary drivers of programming, this study aimed to capture embryonic gene and protein changes in the whole embryo at the time of nutritional insult rather than downstream phenotypic effects. By using a cross-over design of two well established models of maternal protein and iron restriction we aimed to identify putative common "gatekeepers" which may drive nutritional programming.Both protein and iron deficiency in utero reduced the nephron complement in adult male Wistar and Rowett Hooded Lister rats (Pproteomic and pathway analyses identified diet-specific and strain-specific gatekeeper genes, proteins and processes which shared a common association with the regulation of the cell cycle, especially the G1/S and G2/M checkpoints, and cytoskeletal remodelling. A cell cycle-specific PCR array confirmed the down-regulation of cyclins with protein restriction and the up-regulation of apoptotic genes with iron deficiency.The timing and experimental design of this study have been carefully controlled to isolate the common molecular mechanisms which may initiate the sequelae of events involved in nutritional programming of embryonic development. We propose that despite differences in the individual genes and proteins affected in each strain and with each diet, the general response to nutrient deficiency in utero is perturbation of the cell cycle, at the level of interaction with the cytoskeleton and the mitotic checkpoints, thereby diminishing control over the integrity of DNA which is allowed to replicate. These findings offer novel insight into the primary causes and mechanisms leading to the pathologies which have been identified by previous

  12. Cell cycle regulation and cytoskeletal remodelling are critical processes in the nutritional programming of embryonic development.

    Directory of Open Access Journals (Sweden)

    Angelina Swali

    Full Text Available Many mechanisms purport to explain how nutritional signals during early development are manifested as disease in the adult offspring. While these describe processes leading from nutritional insult to development of the actual pathology, the initial underlying cause of the programming effect remains elusive. To establish the primary drivers of programming, this study aimed to capture embryonic gene and protein changes in the whole embryo at the time of nutritional insult rather than downstream phenotypic effects. By using a cross-over design of two well established models of maternal protein and iron restriction we aimed to identify putative common "gatekeepers" which may drive nutritional programming.Both protein and iron deficiency in utero reduced the nephron complement in adult male Wistar and Rowett Hooded Lister rats (P<0.05. This occurred in the absence of damage to the glomerular ultrastructure. Microarray, proteomic and pathway analyses identified diet-specific and strain-specific gatekeeper genes, proteins and processes which shared a common association with the regulation of the cell cycle, especially the G1/S and G2/M checkpoints, and cytoskeletal remodelling. A cell cycle-specific PCR array confirmed the down-regulation of cyclins with protein restriction and the up-regulation of apoptotic genes with iron deficiency.The timing and experimental design of this study have been carefully controlled to isolate the common molecular mechanisms which may initiate the sequelae of events involved in nutritional programming of embryonic development. We propose that despite differences in the individual genes and proteins affected in each strain and with each diet, the general response to nutrient deficiency in utero is perturbation of the cell cycle, at the level of interaction with the cytoskeleton and the mitotic checkpoints, thereby diminishing control over the integrity of DNA which is allowed to replicate. These findings offer novel

  13. Organ damage mitigation with the Baskent Sickle Cell Medical Care Development Program (BASCARE).

    Science.gov (United States)

    Ozdogu, Hakan; Boga, Can; Asma, Suheyl; Kozanoglu, Ilknur; Gereklioglu, Cigdem; Yeral, Mahmut; Buyukkurt, Nurhilal Turgut; Solmaz, Soner; Korur, Aslı; Aytan, Pelin; Maytalman, Erkan; Kasar, Mutlu

    2018-02-01

    The Eastern Mediterranean is among the regions where sickle cell disease (SCD) is common. The morbidity and mortality of this disease can be postponed to adulthood through therapies implemented in childhood. The present study focuses on the organ damage-reducing effects of the Baskent Sickle Cell Medical Care Development Program (BASCARE), which was developed by a team who lives in this region and has approximately 25 years of experience. The deliverables of the program included the development of an electronic health recording system (PRANA) and electronic vaccination system; the use of low citrate infusion in routine prophylactic automatic erythrocyte exchange (ARCE) programs including pregnant women; the use of leukocyte-filtered and irradiated blood for transfusion; the use of magnetic resonance imaging methods (T2) for the management of transfusion-related hemosiderosis; and the implementation of an allogeneic hematopoietic stem cell transplantation protocol for adult patients. The sample was composed of 376 study subjects and 249 control subjects. The hospital's Data Management System and the central population operating system were used for data collection. BASCARE enabled better analysis and interpretation of complication and mortality data. Vaccination rates against influenza and pneumococcal disease improved (21.5% vs 50.8% and 21.5% vs 49.2%, respectively). Effective and safe ARCE with low citrate infusion were maintained in 352 subjects (1003 procedures). Maternal and fetal mortality was prevented in 35 consecutive pregnant patients with ARCE. Chelating therapy rates reduced from 6.7% to 5%. Successful outcomes could be obtained in all 13 adult patients who underwent allogeneic peripheral stem cell transplantation from a fully matched, related donor. No patients died by day 100 or after the first year. Cure could be achieved without graft loss, grades III to IV acute graft versus host disease, extensive chronic graft versus host disease, or other major

  14. Fuel Cell Demonstration Program

    Energy Technology Data Exchange (ETDEWEB)

    Gerald Brun

    2006-09-15

    In an effort to promote clean energy projects and aid in the commercialization of new fuel cell technologies the Long Island Power Authority (LIPA) initiated a Fuel Cell Demonstration Program in 1999 with six month deployments of Proton Exchange Membrane (PEM) non-commercial Beta model systems at partnering sites throughout Long Island. These projects facilitated significant developments in the technology, providing operating experience that allowed the manufacturer to produce fuel cells that were half the size of the Beta units and suitable for outdoor installations. In 2001, LIPA embarked on a large-scale effort to identify and develop measures that could improve the reliability and performance of future fuel cell technologies for electric utility applications and the concept to establish a fuel cell farm (Farm) of 75 units was developed. By the end of October of 2001, 75 Lorax 2.0 fuel cells had been installed at the West Babylon substation on Long Island, making it the first fuel cell demonstration of its kind and size anywhere in the world at the time. Designed to help LIPA study the feasibility of using fuel cells to operate in parallel with LIPA's electric grid system, the Farm operated 120 fuel cells over its lifetime of over 3 years including 3 generations of Plug Power fuel cells (Lorax 2.0, Lorax 3.0, Lorax 4.5). Of these 120 fuel cells, 20 Lorax 3.0 units operated under this Award from June 2002 to September 2004. In parallel with the operation of the Farm, LIPA recruited government and commercial/industrial customers to demonstrate fuel cells as on-site distributed generation. From December 2002 to February 2005, 17 fuel cells were tested and monitored at various customer sites throughout Long Island. The 37 fuel cells operated under this Award produced a total of 712,635 kWh. As fuel cell technology became more mature, performance improvements included a 1% increase in system efficiency. Including equipment, design, fuel, maintenance

  15. Influence of Schistosoma japonicum programmed cell death protein 10 on the growth and development of schistosomula.

    Science.gov (United States)

    Gao, Yan Ru; Huang, Wen Ling; Tang, Chun Lian; Liu, Rong; Zhao, Qin Ping; Ming, Zhen Ping; Dong, Hui Fen

    2018-01-18

    Schistosomiasis caused by Schistosoma japonicum is among the most serious endemic zoonoses in China. To study interactions between schistosomula, the pre-adult juvenile stage, and hosts, it is important to study the functions of key genes involved in schistosomula growth and development. Programmed cell death protein 10 (pcdp10) is an important apoptosis-related gene with various biological functions. This study described the molecular characterization of S. japonicum PCDP10 (SjPCDP10) and evaluated its functions in schistosomula. Real-time quantitative polymerase chain reaction (qPCR) and western blot were used to detect Sjpcdp10 mRNA and protein levels, respectively, at different developmental stages. Immunolocalization was performed to determine SjPCDP10 expression in the parasite. RNA interference (RNAi) experiments were used to assess gene functions associated with SjPCDP10 in schistosomula growth and development. Real-time qPCR revealed that Sjpcdp10 was expressed during all investigated developmental stages and upregulated during schistosomula growth and development. Histochemical localization showed that SjPCDP10 was mainly distributed in the teguments of schistosomula in all investigated stages and part of the parenchymal area of 14-, 18-, and 21-day-old schistosomula. Following Sjpcdp10 knockdown by RNAi, the lengths, widths, areas, and volumes of schistosomula were significantly lower than those in the control group. Scanning electron microscopy showed that the body surfaces of schistosomula subjected to RNAi were seriously damaged, with few tegumental spines and sensory papillae. Transmission electron microscopy indicated that the teguments of Sjpcdp10-knockdown schistosomula were incomplete, the number of layers was reduced, and the thickness decreased significantly as compared with those in the control group. Furthermore, terminal deoxynucleotidyl transferase dUTP nick-end labelling results showed that the rate of apoptosis in Sjpcdp10-knockdown

  16. Role of a Transcriptional Regulator in Programmed Cell Death and Plant Development

    Energy Technology Data Exchange (ETDEWEB)

    Julie M. Stone

    2008-09-13

    The long-term goal of this research is to understand the role(s) and molecular mechanisms of programmed cell death (PCD) in the controlling plant growth, development and responses to biotic and abiotic stress. We developed a genetic selection scheme to identify A. thaliana FB1-resistant (fbr) mutants as a way to find genes involved in PCD (Stone et al., 2000; Stone et al., 2005; Khan and Stone, 2008). The disrupted gene in fbr6 (AtSPL14) responsible for the FB1-insensitivity and plant architecture phenotypes encodes a plant-specific SBP DNA-binding domain transcriptional regulator (Stone et al., 2005; Liang et al., 2008). This research plan is designed to fill gaps in the knowledge about the role of SPL14 in plant growth and development. The work is being guided by three objectives aimed at determining the pathways in which SPL14 functions to modulate PCD and/or plant development: (1) determine how SPL14 functions in plant development, (2) identify target genes that are directly regulated by SPL14, and (3) identify SPL14 modifications and interacting proteins. We made significant progress during the funding period. Briefly, some major accomplishments are highlighted below: (1) To identify potential AtSPL14 target genes, we identified a consensus DNA binding site for the AtSPL14 SBP DNA-binding domain using systematic evolution of ligands by exponential selection (SELEX) and site-directed mutagenesis (Liang et al., 2008). This consensus binding site was used to analyze Affymetrix microarray gene expression data obtained from wild-type and fbr6 mutant plants to find possible AtSPL14-regulated genes. These candidate AtSPL14-regulated genes are providing new information on the molecular mechanisms linking plant PCD and plant development through modulation of the 26S proteasome. (2) Transgenic plants expressing epitope-tagged versions of AtSPL14 are being used to confirm the AtSPL14 targets (by ChIP-PCR) and further dissect the molecular interactions (Nazarenus, Liang

  17. Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway.

    Science.gov (United States)

    Sawamoto, K; Taguchi, A; Hirota, Y; Yamada, C; Jin, M H; Okano, H

    1998-04-01

    We studied the role of Ras signaling in the regulation of cell death during Drosophila eye development. Overexpression of Argos, a diffusible inhibitor of the EGF receptor and Ras signaling, caused excessive cell death in developing eyes at pupal stages. The Argos-induced cell death was suppressed by coexpression of the anti-apoptotic genes p35, diap1, or diap2 in the eye as well as by the Df(3L)H99 chromosomal deletion that lacks three apoptosis-inducing genes, reaper, head involution defective (hid) and grim. Transient misexpression of the activated Ras1 protein (Ras1V12) later in pupal development suppressed the Argos-induced cell death. Thus, Argos-induced cell death seemed to have resulted from the suppression of the anti-apoptotic function of Ras. Conversely, cell death induced by overexpression of Hid was suppressed by gain-of-function mutations of the genes coding for MEK and ERK. These results support the idea that Ras signaling functions in two distinct processes during eye development, first triggering the recruitment of cells and later negatively regulating cell death.

  18. Development of a Renewable Hydrogen Production and Fuel Cell Education Program

    Energy Technology Data Exchange (ETDEWEB)

    Mann, Michael D. [Univ. of North Dakota, Grand Forks, ND (United States)

    2011-11-20

    This report presents the results of a program designed to develop an education program to 1) Provide exposure to the basics of hydrogen-based technologies to a large number of students. This exposure will provide a level of training that will allow students to converse and work with other scientists and engineers in this field. It will also serve to spark a level of interest in a subset of students who will then continue with more advanced coursework and/or research; 2) Provide a “mid-level” training to a moderate level of students. More detailed and directed education will provide students with the ability to work to support industry and government development of hydrogen technologies. This level of training would be sufficient to work in the industry, but not be a leader in research and development; and 3) Provide detailed training to a smaller subset of students with a strong interest and propensity to make significant contributions to the technology development. These individuals will have extensive hands-on experience through internships that will play a major role in industry, government, and academia.

  19. Vehicle Technologies and Fuel Cell Technologies Office Research and Development Programs: Prospective Benefits Assessment Report for Fiscal Year 2018

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, T. S. [Argonne National Lab. (ANL), Argonne, IL (United States); Birky, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Gohlke, David [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-11-01

    Under a diverse set of programs, the Vehicle Technologies and Fuel Cell Technologies Offices of the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy invest in early-stage research of advanced batteries and electrification, engines and fuels, materials, and energy-efficient mobility systems; hydrogen production, delivery, and storage; and fuel cell technologies. This report documents the estimated benefits of successful development and implementation of advanced vehicle technologies. It presents a comparison of a scenario with completely successful implementation of Vehicle Technologies Office (VTO) and Fuel Cell Technologies Office (FCTO) technologies (the Program Success case) to a future in which there is no contribution after Fiscal Year 2017 by the VTO or FCTO to these technologies (the No Program case). Benefits were attributed to individual program technology areas, which included FCTO research and development and the VTO programs of electrification, advanced combustion engines and fuels, and materials technology. Projections for the Program Success case indicate that by 2035, the average fuel economy of on-road, light-duty vehicle stock could be 24% to 30% higher than in the No Program case, while fuel economy for on-road medium- and heavy-duty vehicle stock could be as much as 13% higher. The resulting petroleum savings in 2035 were estimated to be as high as 1.9 million barrels of oil per day, and reductions in greenhouse gas emissions were estimated to be as high as 320 million metric tons of carbon dioxide equivalent per year. Projections of light-duty vehicle adoption indicate that although advanced-technology vehicles may be somewhat more expensive to purchase, the fuel savings result in a net reduction of consumer cost. In 2035, reductions in annual fuel expenditures for vehicles (both light- and heavy-duty) are projected to range from $86 billion to $109 billion (2015$), while the projected increase in new vehicle

  20. Development of amino- and dimethylcarbamate-substituted resorcinol as programmed cell death-1 (PD-1) inhibitor.

    Science.gov (United States)

    Liu, An; Dong, Lei; Wei, Xiao-Li; Yang, Xiao-Hong; Xiao, Jun-Hai; Liu, Zai-Qun

    2016-06-10

    Blockading the interaction of programmed death-1 (PD-1) protein with its ligands (PD-Ls, such as PD-L1) was proved to be a pathway for suppressing the development of tumors and other degradations of biological species. Thus, finding PD-1 inhibitors situated at the convergence point of drug discovery. In addition to some monoclonal antibodies applied to treat cancers clinically, the screening of organic molecules for hindering the interaction of PD-1 with PD-L1 became an efficient strategy in the development of PD-1 inhibitors. We herein applied resorcinol and 3-hydroxythiophenol as the core to link with N,N-dimethylcarbamate and other alkyl-substituted amines to afford 13 amine-appended phenyl dimethylcarbamates (AAPDs). The test for blockading the combination of PD-1 with PD-L1 revealed that abilities of 13 AAPDs were higher than that of sulfamethizole, a successful PD-1 inhibitor. In particular, large hydrophobic substituents at amine moiety or a nitro at resorcinol skeleton enhanced the inhibitory effect of AAPD even higher than that of sulfamethoxypyridazine, another successful PD-1 inhibitor. The present results may provide valuable information for further investigation on synthetic PD-1 inhibitors. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. LFR Development: Italian Program

    International Nuclear Information System (INIS)

    Tarantino, M.

    2011-01-01

    Conclusions: ⇨ ENEA has one of the most relevant EU R&D infrastructures for HLM technological development; ⇨ ENEA is strongly involved in the EU R&D programs supporting the development of sub-critical (ADS) and critical lead cooled reactors (LFR - Gen. IV); ⇨ Large experimental program ranging from HLM thermalhydraulic to large scale experiment has been implemented in Italy, partially funded by the National Program; ⇨ Large competencies are available related to Safety Assessment, System Design, Core Design & Optimization; ⇨ ENEA is able to cooperate with other laboratories in order to promote the growth and diffusion of the technology for nuclear application

  2. Development of a single cell spherical shell model for an investigation of electrical properties with a computing program

    Directory of Open Access Journals (Sweden)

    Boonlamp, M.

    2005-03-01

    Full Text Available A spherical double shell model (SDM for a single cell has been developed, using Laplace’s equation in spherical coordinates and boundary conditions. Electric field intensities and dielectric constants of each region inside and outside of the cell have been estimated. The dielectrophoretic spectrum of the real part of a complex function (Re[f ( ω] were computed using Visual Foxpro Version 6, which gave calculated values pertaining to electrical properties of the cell model as compared with experimental values. The process was repeated until the error percentile was in an acceptable range. The calculated parameters were the dielectric constants and the conductivities of the inner cytoplasm ( εic, σic, the outer cytoplasm ( εoc, σoc, the inner membrane ( εim, σim, the outer membrane ( εom, σom, the suspending solution( εs, σs and the thickness of each layer (dom, doc, dim, respectively. This computer program provides estimated values of cell electrical properties with high accuracy and required minimal computational time.

  3. [Nobel Prize for Physiology or Medicine 2002 is awarded for research into the genetic regulation of organ development and programmed cell death].

    Science.gov (United States)

    Dijkstra, C D

    2002-12-28

    The human body consists of hundreds of cell types, all originating from one fertilized egg. During the embryonic and foetal periods, the number of each cell type increases dramatically. The cells mature and become specialised to form the various tissues and organs of the body. Large numbers of cells are also formed in the adult body. Cell death is a normal process, which runs parallel to this generation of new cells. It takes place in both the foetus and adult, thereby maintaining the appropriate number of cells in the tissues. This delicate, controlled elimination of cells is termed programmed cell death or apoptosis. This year's Nobel laureates in Physiology or Medicine (Sydney Brenner, H. Robert Horvitz and John E.Sulston) have made seminal discoveries relating to the genetic regulation of organ development and programmed cell death. The nematode Caenorhabditis elegans was used as an experimental model system for following cell division and differentiation from the fertilized egg to the adult. The laureates have identified key genes that regulate organ development and programmed cell death and have also shown that corresponding genes exist in higher species, including humans. The discoveries are important for medical research and have shed new light on the pathogenesis of many diseases.

  4. 1986 fuel cell seminar: Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    None

    1986-10-01

    Ninety nine brief papers are arranged under the following session headings: gas industry's 40 kw program, solid oxide fuel cell technology, phosphoric acid fuel cell technology, molten carbonate fuel cell technology, phosphoric acid fuel cell systems, power plants technology, fuel cell power plant designs, unconventional fuels, fuel cell application and economic assessments, and plans for commerical development. The papers are processed separately for the data base. (DLC)

  5. Workforce Development Education Program. Program Review. Report.

    Science.gov (United States)

    Gray, Dorothy; Harkreader, Steve; Wagar, Deborah

    The performance of Florida's Workforce Development Education Program was reviewed. The following were among the data considered: (1) data on program enrollment, program completion, and earnings; (2) data on workforce programs provided from 1992-1993 to 1998-1999; and (3) the 97 responses obtained in a telephone survey of 418 Florida businesses…

  6. Obsolescence Management Program Development

    Energy Technology Data Exchange (ETDEWEB)

    Clancey, C.; Santoro, R.

    2015-07-01

    The nuclear power operators have minimal control over when a manufacturer discontinues supporting or fabricating replacement parts and components, however, proactive planning can minimize the impact and potential high costs of these obsolescence issues. The objective of an obsolescence management program is to ensure that obsolescence is managed as an integral part of plant processes, from identification and prioritization of upcoming challenges, to implementation of obsolescence solutions. This ensures that the impact of obsolescence on equipment reliability is minimized and the most cost-effective solution is implemented. This paper presents an industry proven obsolescence management program development strategy. (Author)

  7. Robotics Technology Development Program

    International Nuclear Information System (INIS)

    1994-02-01

    The Robotics Technology Development Program (RTDP) is a ''needs-driven'' effort. A lengthy series of presentations and discussions at DOE sites considered critical to DOE's Environmental Restoration and Waste Management (EM) Programs resulted in a clear understanding of needed robotics applications toward resolving definitive problems at the sites. A detailed analysis of the Tank Waste Retrieval (TWR), Contaminant Analysis Automation (CAA), Mixed Waste Operations (MWO), and Decontamination ampersand Dismantlement (D ampersand D). The RTDP Group realized that much of the technology development was common (Cross Cutting-CC) to each of these robotics application areas, for example, computer control and sensor interface protocols. Further, the OTD approach to the Research, Development, Demonstration, Testing, and Evaluation (RDDT ampersand E) process urged an additional organizational break-out between short-term (1--3 years) and long-term (3--5 years) efforts (Advanced Technology-AT). The RDTP is thus organized around these application areas -- TWR, CAA, MWO, D ampersand D and CC ampersand AT -- with the first four developing short-term applied robotics. An RTDP Five-Year Plan was developed for organizing the Program to meet the needs in these application areas

  8. Importance of Nongovernmental Organizations for the Establishment of a Successful Hematopoietic Stem-Cell Transplantation Program in a Developing Country

    Directory of Open Access Journals (Sweden)

    Monica M. Rivera Franco

    2018-02-01

    Full Text Available Purpose: In low- and middle-income countries with limited resources, the success of a hematopoietic stem-cell transplantation (HSCT program relies directly on its affordability while obtaining similar outcomes to developed regions. The objective of this study was to describe the experience of a tertiary/referral center in Mexico City performing HSCT with the subsidy of a nongovernmental organization (NGO. Patients and Methods: We performed a retrospective analysis including 146 patients who underwent HSCT at the National Institutes of Health Sciences and Nutrition Salvador Zubiran and were subsidized by the NGO Unidos. Results: Seventy-five patients (51% and 71 patients (49% underwent autologous and allogeneic HSCT, respectively. The median age was 30 years, 56% did not obtain a bachelor’s degree, 79% had a low socioeconomic level, and 75% were unemployed. None had any health coverage. According to the real patient out-of-pocket expense, the subsidy by Unidos corresponded to 88% and 72% in autologous and allogeneic HSCT, respectively. Conclusion: Our results highlight that undergoing an HSCT was feasible for vulnerable patients because of the subsidy of medications and chemotherapy by Unidos. Therefore, creating NGOs in developing countries is important to provide complex medical procedures, such as HSCT, at limited-resource centers to underserved populations while obtaining good outcomes.

  9. Biofuels feedstock development program

    International Nuclear Information System (INIS)

    Wright, L.L.; Cushman, J.H.; Ehrenshaft, A.R.; McLaughlin, S.B.; McNabb, W.A.; Martin, S.A.; Ranney, J.W.; Tuskan, G.A.; Turhollow, A.F.

    1993-11-01

    The Department of Energy's (DOE's) Biofuels Feedstock Development Program (BFDP) leads the nation in the research, development, and demonstration of environmentally acceptable and commercially viable dedicated feedstock supply systems (DFSS). The purpose of this report is to highlight the status and accomplishments of the research that is currently being funded by the BFDP. Highlights summarized here and additional accomplishments are described in more detail in the sections associated with each major program task. A few key accomplishments include (1) development of a methodology for doing a cost-supply analysis for energy crops and the application of that methodology to looking at possible land use changes around a specific energy facility in East Tennessee; (2) preliminary documentation of the relationship between woody crop plantation locations and bird diversity at sites in the Midwest, Canada, and the pacific Northwest supplied indications that woody crop plantations could be beneficial to biodiversity; (3) the initiation of integrated switchgrass variety trials, breeding research, and biotechnology research for the south/southeast region; (4) development of a data base management system for documenting the results of herbaceous energy crop field trials; (5) publication of three issues of Energy Crops Forum and development of a readership of over 2,300 individuals or organizations as determined by positive responses on questionnaires

  10. Automatic Program Development

    DEFF Research Database (Denmark)

    Automatic Program Development is a tribute to Robert Paige (1947-1999), our accomplished and respected colleague, and moreover our good friend, whose untimely passing was a loss to our academic and research community. We have collected the revised, updated versions of the papers published in his ...... a renewed stimulus for continuing and deepening Bob's research visions. A familiar touch is given to the book by some pictures kindly provided to us by his wife Nieba, the personal recollections of his brother Gary and some of his colleagues and friends....... honor in the Higher-Order and Symbolic Computation Journal in the years 2003 and 2005. Among them there are two papers by Bob: (i) a retrospective view of his research lines, and (ii) a proposal for future studies in the area of the automatic program derivation. The book also includes some papers...

  11. Program development fund

    International Nuclear Information System (INIS)

    1989-03-01

    It is the objective of the Fund to encourage innovative research to maintain the Laboratory's position at the forefront of science. Funds are used to explore new ideas and concepts that may potentially develop into new directions of research for the Laboratory and that are consistent with the major needs, overall goals, and mission of the Laboratory and the DOE. The types of projects eligible for support from PDF include: work in forefront areas of science and technology for the primary purpose of enriching Laboratory research and development capabilities; advanced study of new hypotheses, new experimental concepts, or innovative approaches to energy problems; experiments directed toward ''proof of principle'' or early determination of the utility of a new concept; and conception, design analyses, and development of experimental devices, instruments, or components. This report is a review of these research programs

  12. ABC Technology Development Program

    International Nuclear Information System (INIS)

    1994-01-01

    The Accelerator-Based Conversion (ABC) facility will be designed to accomplish the following mission: 'Provide a weapon's grade plutonium disposition capability in a safe, economical, and environmentally sound manner on a prudent schedule for [50] tons of weapon's grade plutonium to be disposed on in [20] years.' This mission is supported by four major objectives: provide a reliable plutonium disposition capability within the next [15] years; provide a level of safety and of safety assurance that meets or exceeds that afforded to the public by modern commercial nuclear power plants; meet or exceed all applicable federal, state, and local regulations or standards for environmental compliance; manage the program in a cost effective manner. The ABC Technology Development Program defines the technology development activities that are required to accomplish this mission. The technology development tasks are related to the following topics: blanket system; vessel systems; reactivity control systems; heat transport system components; energy conversion systems; shutdown heat transport systems components; auxiliary systems; technology demonstrations - large scale experiments

  13. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.

    Science.gov (United States)

    Itoh-Nakadai, Ari; Hikota, Reina; Muto, Akihiko; Kometani, Kohei; Watanabe-Matsui, Miki; Sato, Yuki; Kobayashi, Masahiro; Nakamura, Atsushi; Miura, Yuichi; Yano, Yoko; Tashiro, Satoshi; Sun, Jiying; Ikawa, Tomokatsu; Ochiai, Kyoko; Kurosaki, Tomohiro; Igarashi, Kazuhiko

    2014-12-01

    Mature lymphoid cells express the transcription repressor Bach2, which imposes regulation on humoral and cellular immunity. Here we found critical roles for Bach2 in the development of cells of the B lineage, commencing from the common lymphoid progenitor (CLP) stage, with Bach1 as an auxiliary. Overexpression of Bach2 in pre-pro-B cells deficient in the transcription factor EBF1 and single-cell analysis of CLPs revealed that Bach2 and Bach1 repressed the expression of genes important for myeloid cells ('myeloid genes'). Bach2 and Bach1 bound to presumptive regulatory regions of the myeloid genes. Bach2(hi) CLPs showed resistance to myeloid differentiation even when cultured under myeloid conditions. Our results suggest that Bach2 functions with Bach1 and EBF1 to promote B cell development by repressing myeloid genes in CLPs.

  14. Programmed cell death of the nucellus during Sechium edule Sw. seed development is associated with activation of caspase-like proteases.

    Science.gov (United States)

    Lombardi, Lara; Casani, Simone; Ceccarelli, Nello; Galleschi, Luciano; Picciarelli, Piero; Lorenzi, Roberto

    2007-01-01

    The nucellus is a maternal tissue that embeds and feeds the developing embryo and secondary endosperm. During seed development, the cells of the nucellus suffer a degenerative process soon after fertilization as the cellular endosperm expands and accumulates reserves. Nucellar cell degeneration has been considered to be a form of developmentally programmed cell death (PCD). It was investigated whether or not this degenerative process is characterized by apoptotic hallmarks. Evidence showed that cell death is mostly localized in the border region of the tissue adjacent to the expanding endosperm. Cell death is accompanied by profound changes in the morphology of the nuclei and by a huge degradation of nuclear DNA. Moreover, an increase of activity of different classes of proteinases is reported, and the induction of caspase-like proteases sensitive to specific inhibitors was detected. Nucellar caspase-like proteases are characterized by an acid pH optimum suggesting a possible localization in the vacuole.

  15. Grid-Optimization Program for Photovoltaic Cells

    Science.gov (United States)

    Daniel, R. E.; Lee, T. S.

    1986-01-01

    CELLOPT program developed to assist in designing grid pattern of current-conducting material on photovoltaic cell. Analyzes parasitic resistance losses and shadow loss associated with metallized grid pattern on both round and rectangular solar cells. Though performs sensitivity studies, used primarily to optimize grid design in terms of bus bar and grid lines by minimizing power loss. CELLOPT written in APL.

  16. Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lázár-Molnár, Eszter; Scandiuzzi, Lisa; Basu, Indranil; Quinn, Thomas; Sylvestre, Eliezer; Palmieri, Edith; Ramagopal, Udupi A.; Nathenson, Stanley G.; Guha, Chandan; Almo, Steven C.

    2017-03-01

    Programmed Cell Death-1 (PD-1) is an inhibitory immune receptor, which plays critical roles in T cell co-inhibition and exhaustion upon binding to its ligands PD-L1 and PD-L2. We report the crystal structure of the human PD-1 ectodomain and the mapping of the PD-1 binding interface. Mutagenesis studies confirmed the crystallographic interface, and resulted in mutant PD-1 receptors with altered affinity and ligand-specificity. In particular, a high-affinity mutant PD-1 (HA PD-1) exhibited 45 and 30-fold increase in binding to PD-L1 and PD-L2, respectively, due to slower dissociation rates. This mutant (A132L) was used to engineer a soluble chimeric Ig fusion protein for cell-based and in vivo studies. HA PD-1 Ig showed enhanced binding to human dendritic cells, and increased T cell proliferation and cytokine production in a mixed lymphocyte reaction (MLR) assay. Moreover, in an experimental model of murine Lewis lung carcinoma, HA PD-1 Ig treatment synergized with radiation therapy to decrease local and metastatic tumor burden, as well as in the establishment of immunological memory responses. Our studies highlight the value of structural considerations in guiding the design of a high-affinity chimeric PD-1 Ig fusion protein with robust immune modulatory properties, and underscore the power of combination therapies to selectively manipulate the PD-1 pathway for tumor immunotherapy.

  17. Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy

    Directory of Open Access Journals (Sweden)

    Eszter Lázár-Molnár

    2017-03-01

    Full Text Available Programmed Cell Death-1 (PD-1 is an inhibitory immune receptor, which plays critical roles in T cell co-inhibition and exhaustion upon binding to its ligands PD-L1 and PD-L2. We report the crystal structure of the human PD-1 ectodomain and the mapping of the PD-1 binding interface. Mutagenesis studies confirmed the crystallographic interface, and resulted in mutant PD-1 receptors with altered affinity and ligand-specificity. In particular, a high-affinity mutant PD-1 (HA PD-1 exhibited 45 and 30-fold increase in binding to PD-L1 and PD-L2, respectively, due to slower dissociation rates. This mutant (A132L was used to engineer a soluble chimeric Ig fusion protein for cell-based and in vivo studies. HA PD-1 Ig showed enhanced binding to human dendritic cells, and increased T cell proliferation and cytokine production in a mixed lymphocyte reaction (MLR assay. Moreover, in an experimental model of murine Lewis lung carcinoma, HA PD-1 Ig treatment synergized with radiation therapy to decrease local and metastatic tumor burden, as well as in the establishment of immunological memory responses. Our studies highlight the value of structural considerations in guiding the design of a high-affinity chimeric PD-1 Ig fusion protein with robust immune modulatory properties, and underscore the power of combination therapies to selectively manipulate the PD-1 pathway for tumor immunotherapy.

  18. Concentrator-solar-cell development

    Science.gov (United States)

    Grenon, L.

    1982-07-01

    A program is described which is a continuation of earlier programs for the development of high-efficiency, low-cost, silicon concentrator solar cells. The base-line process steps and process sequences identified in these earlier contracts were evaluated and specific processes reviewed. In particular, emphasis on the use of Czochralski-grown silicon wafers rather than float-zone wafers were examined. Additionally, a study of the trade-offs between textured and nontextured cells was initiated, and the limits within which the low-cost plated nickel copper metallization can be used in concentrator solar cell applications was identified.

  19. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.

    Science.gov (United States)

    Ortega-Molina, Ana; Boss, Isaac W; Canela, Andres; Pan, Heng; Jiang, Yanwen; Zhao, Chunying; Jiang, Man; Hu, Deqing; Agirre, Xabier; Niesvizky, Itamar; Lee, Ji-Eun; Chen, Hua-Tang; Ennishi, Daisuke; Scott, David W; Mottok, Anja; Hother, Christoffer; Liu, Shichong; Cao, Xing-Jun; Tam, Wayne; Shaknovich, Rita; Garcia, Benjamin A; Gascoyne, Randy D; Ge, Kai; Shilatifard, Ali; Elemento, Olivier; Nussenzweig, Andre; Melnick, Ari M; Wendel, Hans-Guido

    2015-10-01

    The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell lymphoma; however, the biological consequences of KMT2D mutations on lymphoma development are not known. Here we show that KMT2D functions as a bona fide tumor suppressor and that its genetic ablation in B cells promotes lymphoma development in mice. KMT2D deficiency also delays germinal center involution and impedes B cell differentiation and class switch recombination. Integrative genomic analyses indicate that KMT2D affects methylation of lysine 4 on histone H3 (H3K4) and expression of a set of genes, including those in the CD40, JAK-STAT, Toll-like receptor and B cell receptor signaling pathways. Notably, other KMT2D target genes include frequently mutated tumor suppressor genes such as TNFAIP3, SOCS3 and TNFRSF14. Therefore, KMT2D mutations may promote malignant outgrowth by perturbing the expression of tumor suppressor genes that control B cell-activating pathways.

  20. Programmed cell death and hybrid incompatibility.

    Science.gov (United States)

    Frank, S A; Barr, C M

    2003-01-01

    We propose a new theory to explain developmental aberrations in plant hybrids. In our theory, hybrid incompatibilities arise from imbalances in the mechanisms that cause male sterility in hermaphroditic plants. Mitochondria often cause male sterility by killing the tapetal tissue that nurtures pollen mother cells. Recent evidence suggests that mitochondria destroy the tapetum by triggering standard pathways of programmed cell death. Some nuclear genotypes repress mitochondrial male sterility and restore pollen fertility. Normal regulation of tapetal development therefore arises from a delicate balance between the disruptive effects of mitochondria and the defensive countermeasures of the nuclear genes. In hybrids, incompatibilities between male-sterile mitochondria and nuclear restorers may frequently upset the regulatory control of programmed cell death, causing tapetal abnormalities and male sterility. We propose that hybrid misregulation of programmed cell death may also spill over into other tissues, explaining various developmental aberrations observed in hybrids.

  1. Programmed cell death in plants and caspase-like activities

    NARCIS (Netherlands)

    Gaussand, Gwénael Martial Daniel Jean-Marie

    2007-01-01

    The development of multicellular organisms involves an important balance between cell growth, cell division and cell death. In animals, programmed cell death (PCD) plays a key role by forming and deleting structures, controlling cell numbers and eliminating abnormal damaged cells. Caspases were

  2. Developing a Stretching Program.

    Science.gov (United States)

    Beaulieu, J E

    1981-11-01

    In brief: Although stretching exercises can prevent muscle injuries and enhance athletic performance, they can also cause injury. The author explains the four most common types of stretching exercises and explains why he considers static stretching the safest. He also sets up a stretching routine for runners. In setting up a safe stretching program, one should (1) precede stretching exercises with a mild warm-up; (2) use static stretching; (3) stretch before and after a workout; (4) begin with mild and proceed to moderate exercises; (5) alternate exercises for muscle groups; (6) stretch gently and slowly until tightness, not pain, is felt; and (7) hold the position for 30 to 60 seconds.

  3. Ansaldo programs on fuel cell vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Marcenaro, B.G.; Federici, F. [Ansaldo Ricerche Srl, Genova (Italy)

    1996-12-31

    The growth in traffic and the importance of maintaining a stable ecology at the global scale, particularly with regard to atmospheric pollution, raises the necessity to realize a new generation of vehicles which are more efficient, more economical and compatible with the environment. At European level, the Car of Tomorrow task force has identified fuel cells as a promising alternative propulsion system. Ansaldo Ricerche has been involved in the development of fuel cell vehicles since the early nineties. Current ongoing programs relates to: (1) Fuel cell bus demonstrator (EQHEPP BUS) Test in 1996 (2) Fuel cell boat demonstrator (EQHHPP BOAT) Test in 1997 (3) Fuel cell passenger car prototype (FEVER) Test in 1997 (4) 2nd generation Fuel cell bus (FCBUS) 1996-1999 (5) 2nd generation Fuel cell passenger car (HYDRO-GEN) 1996-1999.

  4. Technical Leadership Development Program

    Science.gov (United States)

    2014-04-30

    analysis and... analysis of industry performance (Y) more me & examples on the fast/slow thinking Add a sec on on crea ng good metrics In class me to work on final...Leadership Style (Y) M4.0 Simula on 1- Leadership Value Proposi on (Y) Some hidden (secret) mo va ons for roles in scenarios/vigne es Develop SWOT

  5. The Biodenitrification Development Program

    International Nuclear Information System (INIS)

    Walker, J.F. Jr.; Helfrich, M.V.; Donaldson, T.L.

    1987-02-01

    Oak Ridge National Laboratory (ORNL) conducted a pilot-plant program in support of the fluidized-bed biodenitrification system currently under construction by Westinghouse, Inc., at the Feed Materials Production Center (FMPC) in Fernald, Ohio. Two 0.1-m-diam bioreactors in series, each with ∼6.1 m of active bed height, and a single 12.2-m-high, 0.1-m-diam fluidized-bed bioreactor were operated to simulate the larger bioreactors (four 1.2-m-diam bioreactors each with 12.2 m of active bed height to be operated in series) under construction at Fernald. These pilot systems were used to verify the Fernald design as well as to identify and attempt to solve any problems that might affect the full-scale system. Results of studies with FMPC wastewater having nitrate levels as high as 10 g/L indicate that the Fernald bioreactors probably cannot operate on untreated wastewater because of its high calcium concentration. When the pilot-plant system was tested with raw wastewater having calcium concentrations ranging from 100 to 450 mg/L, the bioreactors ceased to function within 5 weeks after startup due to the buildup of calcium carbonate on the bioparticles. However, Fernald wastewater has been softened at ORNL and successfully biodenitrified. The results obtained to date indicate that the biodenitrification rate used in the design of the Fernald bioreactors, 32 kg (NO 3 -N)/d x m 3 , may be achieved or exceeded; however, pH adjustment within the bioreactors may be necessary. The temperature rise may be as high as 4 0 C in each bioreactor due to the exothermic nature of the biodenitrification reaction. Under limiting adiabatic conditions, the overall temperature rise through four columns could be 15 to 20 0 C. Thus, some kind of temperature control will probably be necessary to achieve optimal performance. 12 refs., 21 figs., 6 tabs

  6. Technical Leadership Development Program

    Science.gov (United States)

    2010-12-13

    the traditional tenets of leadership and management , systems thinking, understanding SOS issues, and thinking and acting holistically. Our research...international element 2.0 Enterprise Leadership and Management UNCLASSIFIED Contract Number: H98230-08-D-0171 DO 002. TO002, RT 004 Report No...mechanisms for leadership of the overall technical effort, for systems engineering, for requirements, management , and for systems integration. o Develop

  7. NCG turbocompressor development program

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, K.E.

    1997-12-31

    Barber-Nichols, Pacific Gas and Electric and UNOCAL as an industry group applied for a DOE grant under the GTO to develop a new type of compressor that could be used to extract non-condensable gas (NCG) from the condensers of geothermal power plants. This grant (DE-FG07-951A13391) was awarded on September 20, 1995. The installation and startup of the turbocompressor at the PG&E Geysers Unit 11 is covered by this paper. The turbocompressor has operated several days at 17000rpm while the plant was producing 50 to 70 MW.

  8. Nanosatellite Propulsion Development Program

    Science.gov (United States)

    Gagosian, J. S.; Rhee, M. S.; Zakrzwski, C. M.

    1999-01-01

    Earth-orbiting nanosatellite constellations are a unique and exciting means toward fulfilling part of the mission of the Goddard Space Flight Center (GSFC). These constellations, which may consist of several hundred 10-kg spacecraft, present unique challenges in the area of propulsion. Many mission concepts require significant delta-v and attitude control capability to reside in the nanosatellites. In response to requirements from mission feasibility studies, such as the Magnetospheric Constellation study, the GSFC has initiated industry and government partnerships to develop enabling propulsion technologies. The largest challenge has been to meet the power constraints of nanosatellites. These power issues, combined with the high thrust required by many of the missions studied, have led the GSFC to concentrate its efforts on chemical propulsion technology. Electric propulsion technologies capable of performing efficiently at very low power are also of interest to the GSFC as potential candidates for nanosatellite formation flying missions. This paper provides the status of specific industrial or government partnerships undertaken by the GSFC to develop nano/micro propulsion components. Three specific technologies are described in detail: 1) Nanosatellite Solid Rocket Motor Prototype 2) Ultra-Low-Power Cold Gas Thruster for Spin-Axis Precession 3) Micro-Machined Solid-Propellant Gas Generators.

  9. Environmental awareness program development

    Science.gov (United States)

    Steinhauer, David A.

    1995-01-01

    Work this summer in the Office of Safety, Environment, and Mission Assurance began with a review of current initiatives and environmental projects at the Langley Research Center (LaRC). This involved researching many of the documents on file which detail problems which have occurred as well as various approaches which have been used to address these problems. A large portion of the time was spent interviewing and working with each of the engineers, industrial hygienists and other professionals connected with the Office of Environmental Engineering. A few of the projects I worked on include: Researching environmental compliance, and pollution prevention efforts; touring many of the facilities at LaRC to observe the environmental efforts in the work place; researching equipment needs for the recycling/reclamation center; writing scripts for in-house training videos; working with the video production department to produce a training video; developing e-mail distribution list; developing environmental coordinator's database; and working with others to research logistics of recycling and waste minimization efforts.

  10. Programmed cell death in plants.

    Science.gov (United States)

    Fomicheva, A S; Tuzhikov, A I; Beloshistov, R E; Trusova, S V; Galiullina, R A; Mochalova, L V; Chichkova, N V; Vartapetian, A B

    2012-12-01

    The modern concepts of programmed cell death (PCD) in plants are reviewed as compared to PCD (apoptosis) in animals. Special attention is focused on considering the potential mechanisms of implementation of this fundamental biological process and its participants. In particular, the proteolytic enzymes involved in PCD in animals (caspases) and plants (phytaspases) are compared. Emphasis is put on elucidation of both common features and substantial differences of PCD implementation in plants and animals.

  11. Wetland Program Development Grants (WPDGs)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Wetland Grant Database (WGD) houses grant data for Wetland Program Development Grants (created by EPA in 1990 under the Clean Water Act Section 104(b)(3)...

  12. Visualization program development using Java

    International Nuclear Information System (INIS)

    Sasaki, Akira; Suto, Keiko

    2002-03-01

    Method of visualization programs using Java for the PC with the graphical user interface (GUI) is discussed, and applied to the visualization and analysis of 1D and 2D data from experiments and numerical simulations. Based on an investigation of programming techniques such as drawing graphics and event driven program, example codes are provided in which GUI is implemented using the Abstract Window Toolkit (AWT). The marked advantage of Java comes from the inclusion of library routines for graphics and networking as its language specification, which enables ordinary scientific programmers to make interactive visualization a part of their simulation codes. Moreover, the Java programs are machine independent at the source level. Object oriented programming (OOP) methods used in Java programming will be useful for developing large scientific codes which includes number of modules with better maintenance ability. (author)

  13. The Cysteine Protease CEP1, a Key Executor Involved in Tapetal Programmed Cell Death, Regulates Pollen Development in Arabidopsis[W][OPEN

    Science.gov (United States)

    Zhang, Dandan; Liu, Di; Lv, Xiaomeng; Wang, Ying; Xun, Zhili; Liu, Zhixiong; Li, Fenglan; Lu, Hai

    2014-01-01

    Tapetal programmed cell death (PCD) is a prerequisite for pollen grain development in angiosperms, and cysteine proteases are the most ubiquitous hydrolases involved in plant PCD. We identified a papain-like cysteine protease, CEP1, which is involved in tapetal PCD and pollen development in Arabidopsis thaliana. CEP1 is expressed specifically in the tapetum from stages 5 to 11 of anther development. The CEP1 protein first appears as a proenzyme in precursor protease vesicles and is then transported to the vacuole and transformed into the mature enzyme before rupture of the vacuole. cep1 mutants exhibited aborted tapetal PCD and decreased pollen fertility with abnormal pollen exine. A transcriptomic analysis revealed that 872 genes showed significantly altered expression in the cep1 mutants, and most of them are important for tapetal cell wall organization, tapetal secretory structure formation, and pollen development. CEP1 overexpression caused premature tapetal PCD and pollen infertility. ELISA and quantitative RT-PCR analyses confirmed that the CEP1 expression level showed a strong relationship to the degree of tapetal PCD and pollen fertility. Our results reveal that CEP1 is a crucial executor during tapetal PCD and that proper CEP1 expression is necessary for timely degeneration of tapetal cells and functional pollen formation. PMID:25035401

  14. Environmental Education and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    The Environmental Education and Development Program is a component on the effort to accomplish the Office of Environmental Restoration and Waste Management`s (EM) goal of environmental compliance and cleanup of the 1989 inventory of inactive DOE sites and facilities by the year 2019. Education and Development programs were designed specifically to stimulate the knowledge and workforce capability necessary to achieve EM goals while contributing to DOE`s overall goal of increasing scientific and technical literacy and competency. The primary implementation criterion for E&D activities involved a focus on programs and projects that had both immediate and long-range leveraging effects on infrastructure. This focus included programs that yielded short term results (one to five years), as well as long-term results, to ensure a steady supply of appropriately trained and educated human resources, including women and minorities, to meet EM`s demands.

  15. Leadership Development for Program Directors

    Science.gov (United States)

    Bing-You, Robert; Wiltshire, Whitney; Skolfield, Jenny

    2010-01-01

    Background Residency program directors have increasingly challenging roles, but they may not be receiving adequate leadership development. Objective To assess and facilitate program directors' leadership self-awareness and development at a workshop retreat. Methods At our annual program director retreat, program directors and associate program directors from a variety of specialties completed the Thomas-Kilmann Conflict Mode Instrument (TKI), which evaluates an individual's behavior in conflict situations, and the Hersey-Blanchard Situational Leadership (HBSL) model, which measures individuals' preferred leadership style in working with followers. Participants received their results during the retreat and discussed their leadership style results in the context of conflict situations experienced in the past. An online survey was distributed 3 weeks after the retreat to assess participant satisfaction and to determine whether participants would make changes to their leadership styles. Results Seventeen program directors attended the retreat and completed the tools. On the TKI, 47% preferred the Compromising mode for handling conflict, while 18% preferred either the Avoiding or Accommodating modes. On the HBSL, 71% of program directors preferred a Coaching leadership style. Ninety-one percent of postretreat-survey respondents found the leadership tools helpful and also thought they had a better awareness of their conflict mode and leadership style preferences. Eighty-two percent committed to a change in their leadership behaviors in the 6 months following the retreat. Conclusions Leadership tools may be beneficial for promoting the professional development of program directors. The TKI and HBSL can be used within a local retreat or workshop as we describe to facilitate positive leadership-behavior changes. PMID:22132267

  16. Leadership Development Program Final Project

    Science.gov (United States)

    Parrish, Teresa C.

    2016-01-01

    TOSC is NASA's prime contractor tasked to successfully assemble, test, and launch the EM1 spacecraft. TOSC success is highly dependent on design products from the other NASA Programs manufacturing and delivering the flight hardware; Space Launch System(SLS) and Multi-Purpose Crew Vehicle(MPCV). Design products directly feed into TOSC's: Procedures, Personnel training, Hardware assembly, Software development, Integrated vehicle test and checkout, Launch. TOSC senior management recognized a significant schedule risk as these products are still being developed by the other two (2) programs; SVE and ACE positions were created.

  17. Tightly Controlled Expression of bHLH142 Is Essential for Timely Tapetal Programmed Cell Death and Pollen Development in Rice

    Directory of Open Access Journals (Sweden)

    Swee-Suak Ko

    2017-07-01

    Full Text Available Male sterility is important for hybrid seed production. Pollen development is regulated by a complex network. We previously showed that knockout of bHLH142 in rice (Oryza sativa causes pollen sterility by interrupting tapetal programmed cell death (PCD and bHLH142 coordinates with TDR to modulate the expression of EAT1. In this study, we demonstrated that overexpression of bHLH142 (OE142 under the control of the ubiquitin promoter also leads to male sterility in rice by triggering the premature onset of PCD. Protein of bHLH142 was found to accumulate specifically in the OE142 anthers. Overexpression of bHLH142 induced early expression of several key regulatory transcription factors in pollen development. In particular, the upregulation of EAT1 at the early stage of pollen development promoted premature PCD in the OE142 anthers, while its downregulation at the late stage impaired pollen development by suppressing genes involved in pollen wall biosynthesis, ROS scavenging and PCD. Collectively, these events led to male sterility in OE142. Analyses of related mutants further revealed the hierarchy of the pollen development regulatory gene network. Thus, the findings of this study advance our understanding of the central role played by bHLH142 in the regulatory network leading to pollen development in rice and how overexpression of its expression affects pollen development. Exploitation of this novel functionality of bHLH142 may confer a big advantage to hybrid seed production.

  18. Child Development Program Evaluation Scale.

    Science.gov (United States)

    Fiene, Richard J.

    The Child Development Program Evaluation Scale (CDPES) is actually two scales in one, a licensing scale and a quality scale. Licensing predictor items have been found to predict overall compliance of child day care centers with state regulations in four states. Quality scale items have been found to predict the overall quality of child day care…

  19. Sphingolipid metabolism and programmed cell death in tomato

    NARCIS (Netherlands)

    Spassieva, Stefanka Diankova

    2003-01-01

    Programmed cell death is genetically determined. When the regulation of the process is disrupted it can have severe or lethal consequences for the organism. In mammals, cancer and neurodegenerative diseases are associated with abnormalities in programmed cell death. Development of an animal embryo

  20. Glucocorticoid programming of intrauterine development.

    Science.gov (United States)

    Fowden, A L; Valenzuela, O A; Vaughan, O R; Jellyman, J K; Forhead, A J

    2016-07-01

    Glucocorticoids (GCs) are important environmental and maturational signals during intrauterine development. Toward term, the maturational rise in fetal glucocorticoid receptor concentrations decreases fetal growth and induces differentiation of key tissues essential for neonatal survival. When cortisol levels rise earlier in gestation as a result of suboptimal conditions for fetal growth, the switch from tissue accretion to differentiation is initiated prematurely, which alters the phenotype that develops from the genotype inherited at conception. Although this improves the chances of survival should delivery occur, it also has functional consequences for the offspring long after birth. Glucocorticoids are, therefore, also programming signals that permanently alter tissue structure and function during intrauterine development to optimize offspring fitness. However, if the postnatal environmental conditions differ from those signaled in utero, the phenotypical outcome of early-life glucocorticoid receptor overexposure may become maladaptive and lead to physiological dysfunction in the adult. This review focuses on the role of GCs in developmental programming, primarily in farm species. It examines the factors influencing GC bioavailability in utero and the effects that GCs have on the development of fetal tissues and organ systems, both at term and earlier in gestation. It also discusses the windows of susceptibility to GC overexposure in early life together with the molecular mechanisms and long-term consequences of GC programming with particular emphasis on the cardiovascular, metabolic, and endocrine phenotype of the offspring. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Creating effective career development programs.

    Science.gov (United States)

    Rubio, Doris McGartland; Robinson, Georgeanna F W B; Gabrilove, Janice; Meagher, Emma A

    2017-04-01

    This paper is the fourth in a 5-part series that focuses on educating and training the clinical and translational science workforce. The goal of this paper is to delineate components of effective career development programs that go beyond didactic training. All academic health centers with a Clinical and Translational Science Award have a KL2 career development award for junior faculty, and many also have a TL1 training program for predoctoral and postdoctoral fellows. The training across these programs varies, however junior investigators across the United States experience similar challenges. Junior investigators can get overwhelmed with the demands of building their own research program, particularly in academia. 1Often, they are sidetracked by competing demands that can derail their progress. In these situations, junior investigators experience frustration and may search for alternative career paths. By providing them with additional professional skills in the 5 domains of: (1) self-awareness; (2) selecting the right topic and securing funding; (3) getting adequate support; (4) working with others; and (5) managing yourself, your career, and your demands. We will give junior investigators additional tools to manage these demands and facilitate their own career success.

  2. Advanced Emissions Control Development Program

    Energy Technology Data Exchange (ETDEWEB)

    A.P.Evans; K.E. Redinger; M.J. Holmes

    1998-04-01

    The objective of the Advanced Emissions Control Development Program (AECDP) is to develop practical, cost-effective strategies for reducing the emissions of air toxics from coal-fired boilers. Ideally, the project aim is to effectively control air toxic emissions through the use of conventional flue gas cleanup equipment such as electrostatic precipitators (ESPS), fabric filters (baghouse), and wet flue gas desulfurization. Development work to date has concentrated on the capture of mercury, other trace metals, fine particulate and hydrogen chloride. Following the construction and evaluation of a representative air toxics test facility in Phase I, Phase II focused on the evaluation of mercury and several other air toxics emissions. The AECDP is jointly funded by the United States Department of Energy's Federal Energy Technology Center (DOE), the Ohio Coal Development Office within the Ohio Department of Development (oCDO), and Babcock& Wilcox-a McDermott company (B&W).

  3. Programming Retinal Stem Cells into Cone Photoreceptors

    Science.gov (United States)

    2015-12-01

    researchers that want to reprogram stem cells for clinical applications. Lastly, we attempted to transplant cone photoreceptors derived from human retinal...AWARD NUMBER: W81XWH-14-1-0566 TITLE: Programming Retinal Stem Cells into Cone Photoreceptors PRINCIPAL INVESTIGATOR: Joseph A. Brzezinski IV...SUBTITLE 5a. CONTRACT NUMBER Programming Retinal Stem Cells into Cone Photoreceptors 5b. GRANT NUMBER W81XWH-14-1-0566 5c. PROGRAM ELEMENT NUMBER 6

  4. Does aging need its own program, or is the program of development quite sufficient for it? Stationary cell cultures as a tool to search for anti-aging factors.

    Science.gov (United States)

    Khokhlov, Alexander N

    2013-02-01

    According to our conception, the aging process is caused by cell proliferation restriction-induced accumulation of various macromolecular defects (mainly DNA damage) in cells of a mature organism or in a cell population. In the case of cell cultures, the proliferation restriction is related to so-called contact inhibition and to the Hayflick's limit, while in the case of multicellular organisms, it is related to the appearance, in the process of differentiation, of organs and tissues consisting of postmitotic and very slowly dividing cells. It is assumed that the proliferation of intact cells prevents accumulation of various errors in a cell population. However, the continuous propagation of all the cells in a multicellular organism is absolutely incompatible with its normal functioning. Thus, the program of development, when it generates postmitotic or slowly dividing cells, automatically leads also to the onset of the aging process (mortality increase with age). Therefore, any additional special program for aging simply becomes unnecessary. This, however, doesn't reject, for some organisms, the reasonability of programmed death, which makes possible the elimination of harmful, from the species point of view, individuals. It is also very important to emphasize that increase or decrease of an organism's lifespan under the effects of various external factors is not always necessarily related to modification of the aging process, though the experimental results in the field are usually interpreted in just this way. I called the experimental-gerontological models similar to the Hayflick's model "correlative", since they are based on some correlations only and not related necessarily to the gist of the aging phenomenon. So, for the Hayflick's model, it is the relationship between population doubling level and donor age, between population doubling potential and species lifespan, between some cell changes in vivo and in vitro, and so forth. If the rationale of the

  5. Professional development and extension programs

    International Nuclear Information System (INIS)

    Bereznai, G.

    2015-01-01

    Professional Development (PD) refers to the means by which people acquire, develop, maintain and enhance the specialist knowledge and skills needed to practice in their profession. Extension Programs (aka Continuing Education) are offered by most post-secondary degree/diploma/certificate granting institutions.The courses are typically taken on a part-time basis, and course delivery often includes distance learning technology. An important implementation of PD is via workplace training, industry specific seminars, workshops and non-credit courses offered by a wide range of service providers.

  6. Wind Energy Career Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Gwen Andersen

    2012-03-29

    Saint Francis University has developed curriculum in engineering and in business that is meeting the needs of students and employers (Task 1) as well as integrating wind energy throughout the curriculum. Through a variety of approaches, the University engaged in public outreach and education that reached over 2,000 people annually (Task 2). We have demonstrated, through the success of these programs, that students are eager to prepare for emerging jobs in alternative energy, that employers are willing to assist in developing employees who understand the broader business and policy context of the industry, and that people want to learn about wind energy.

  7. Deciphering the Innate Lymphoid Cell Transcriptional Program

    Directory of Open Access Journals (Sweden)

    Cyril Seillet

    2016-10-01

    Full Text Available Innate lymphoid cells (ILCs are enriched at mucosal surfaces, where they provide immune surveillance. All ILC subsets develop from a common progenitor that gives rise to pre-committed progenitors for each of the ILC lineages. Currently, the temporal control of gene expression that guides the emergence of these progenitors is poorly understood. We used global transcriptional mapping to analyze gene expression in different ILC progenitors. We identified PD-1 to be specifically expressed in PLZF+ ILCp and revealed that the timing and order of expression of the transcription factors NFIL3, ID2, and TCF-1 was critical. Importantly, induction of ILC lineage commitment required only transient expression of NFIL3 prior to ID2 and TCF-1 expression. These findings highlight the importance of the temporal program that permits commitment of progenitors to the ILC lineage, and they expand our understanding of the core transcriptional program by identifying potential regulators of ILC development.

  8. Developing a successful robotics program.

    Science.gov (United States)

    Luthringer, Tyler; Aleksic, Ilija; Caire, Arthur; Albala, David M

    2012-01-01

    Advancements in the robotic surgical technology have revolutionized the standard of care for many surgical procedures. The purpose of this review is to evaluate the important considerations in developing a new robotics program at a given healthcare institution. Patients' interest in robotic-assisted surgery has and continues to grow because of improved outcomes and decreased periods of hospitalization. Resulting market forces have created a solid foundation for the implementation of robotic surgery into surgical practice. Given proper surgeon experience and an efficient system, robotic-assisted procedures have been cost comparable to open surgical alternatives. Surgeon training and experience is closely linked to the efficiency of a new robotics program. Formally trained robotic surgeons have better patient outcomes and shorter operative times. Training in robotics has shown no negative impact on patient outcomes or mentor learning curves. Individual economic factors of local healthcare settings must be evaluated when planning for a new robotics program. The high cost of the robotic surgical platform is best offset with a large surgical volume. A mature, experienced surgeon is integral to the success of a new robotics program.

  9. Psychotherapeutic Medications Development Program (PMDP).

    Science.gov (United States)

    Haigler, H J; Cott, J M; Rudorfer, M V; Schoenfeld, R E; Potter, W Z; Vitiello, B; Everist, H D

    1993-01-01

    The Psychotherapeutic Medications Development Program (PMDP) of the National Institute of Mental Health was established in 1990. The purpose of the PMDP is to improve, enhance, and speed the development of new medications and improve the therapeutic usefulness of existing medications for the treatment of mental illness. The PMDP will fulfill this mission by implementing four initiatives. In the drug discovery and development initiative, the PMDP will aid in the development of promising new drugs. This initiative will also include improving the therapeutic usefulness of existing medications. In the technology transfer initiative, PMDP will improve the technology transfer from academic and government researchers to the pharmaceutical industry; improve the dissemination of information concerning technology transfer opportunities as it pertains to psychotherapeutic medications; and enhance technology transfer by acting as a broker to bring interested parties together. For the third initiative, the PMDP will develop and maintain a capability to clinically evaluate psychotherapeutic medications. The PMDP will also act to facilitate the development and testing of new concepts and models of mental illness. There is a detailed description of the steps that are involved in developing a new chemical entity (NCE) from the conceptual stage to a medication that is approved for the treatment of a particular illness. The pharmaceutical industry estimates that this medication development process costs $238 million.

  10. Program development fund: FY 1987

    Energy Technology Data Exchange (ETDEWEB)

    1989-03-01

    It is the objective of the Fund to encourage innovative research to maintain the Laboratory's position at the forefront of science. Funds are used to explore new ideas and concepts that may potentially develop into new directions of research for the Laboratory and that are consistent with the major needs, overall goals, and mission of the Laboratory and the DOE. The types of projects eligible for support from PDF include: work in forefront areas of science and technology for the primary purpose of enriching Laboratory research and development capabilities; advanced study of new hypotheses, new experimental concepts, or innovative approaches to energy problems; experiments directed toward ''proof of principle'' or early determination of the utility of a new concept; and conception, design analyses, and development of experimental devices, instruments, or components. This report is a review of these research programs.

  11. Program summary for the Civilian Reactor Development Program

    International Nuclear Information System (INIS)

    1982-07-01

    This Civilian Reactor Development Program document has the prime purpose of summarizing the technical programs supported by the FY 1983 budget request. This section provides a statement of the overall program objectives and a general program overview. Section II presents the technical programs in a format intended to show logical technical interrelationships, and does not necessarily follow the structure of the formal budget presentation. Section III presents the technical organization and management structure of the program

  12. 23 CFR 660.109 - Program development.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Program development. 660.109 Section 660.109 Highways... PROGRAMS (DIRECT FEDERAL) Forest Highways § 660.109 Program development. (a) The FHWA will arrange and... program will be selected considering the following criteria: (1) The development, utilization, protection...

  13. Hemoglobins, programmed cell death and somatic embryogenesis.

    Science.gov (United States)

    Hill, Robert D; Huang, Shuanglong; Stasolla, Claudio

    2013-10-01

    Programmed cell death (PCD) is a universal process in all multicellular organisms. It is a critical component in a diverse number of processes ranging from growth and differentiation to response to stress. Somatic embryogenesis is one such process where PCD is significantly involved. Nitric oxide is increasingly being recognized as playing a significant role in regulating PCD in both mammalian and plant systems. Plant hemoglobins scavenge NO, and evidence is accumulating that events that modify NO levels in plants also affect hemoglobin expression. Here, we review the process of PCD, describing the involvement of NO and plant hemoglobins in the process. NO is an effector of cell death in both plants and vertebrates, triggering the cascade of events leading to targeted cell death that is a part of an organism's response to stress or to tissue differentiation and development. Expression of specific hemoglobins can alter this response in plants by scavenging the NO, thus, interrupting the death process. Somatic embryogenesis is used as a model system to demonstrate how cell-specific expression of different classes of hemoglobins can alter the embryogenic process, affecting hormone synthesis, cell metabolite levels and genes associated with PCD and embryogenic competence. We propose that plant hemoglobins influence somatic embryogenesis and PCD through cell-specific expression of a distinct plant hemoglobin. It is based on the premise that both embryogenic competence and PCD are strongly influenced by cellular NO levels. Increases in cellular NO levels result in elevated Zn(2+) and reactive-oxygen species associated with PCD, but they also result in decreased expression of MYC2, a transcription factor that is a negative effector of indoleacetic acid synthesis, a hormone that positively influences embryogenic competence. Cell-specific hemoglobin expression reduces NO levels as a result of NO scavenging, resulting in cell survival. Copyright © 2013 Elsevier Ireland Ltd

  14. Thoria powder process development (LWBR Development Program)

    Energy Technology Data Exchange (ETDEWEB)

    Hutchison, C.R.; Lloyd, R.

    1979-10-01

    The development program to identify the critical parameters for the process of converting thorium nitrate solution into thoria powder is described. Thorium oxalate hexahydrate is precipitated from the reaction of thorium nitrate solution with oxalic acid. The resulting thorium oxalate hexahydrate slurry is filter pressed into a cake which is air calcined to form thoria powder. Changes in the critical processing parameters such as free nitric acid content of the thorium nitrate solution, precipitation temperature, and calcining temperature altered the thoria powder characteristics, and thus its capability for being fabricated into fuel pellets. The objective of the powder preparation effort was to obtain thoria powders which could be formed by conventional ceramic fabrication techniques into thoria and thoria-urania pellets of high density and high integrity having a nearly uniform large grain structure.

  15. Thoria powder process development (LWBR Development Program)

    International Nuclear Information System (INIS)

    Hutchison, C.R.; Lloyd, R.

    1979-10-01

    The development program to identify the critical parameters for the process of converting thorium nitrate solution into thoria powder is described. Thorium oxalate hexahydrate is precipitated from the reaction of thorium nitrate solution with oxalic acid. The resulting thorium oxalate hexahydrate slurry is filter pressed into a cake which is air calcined to form thoria powder. Changes in the critical processing parameters such as free nitric acid content of the thorium nitrate solution, precipitation temperature, and calcining temperature altered the thoria powder characteristics, and thus its capability for being fabricated into fuel pellets. The objective of the powder preparation effort was to obtain thoria powders which could be formed by conventional ceramic fabrication techniques into thoria and thoria-urania pellets of high density and high integrity having a nearly uniform large grain structure

  16. CELSS research and development program

    Science.gov (United States)

    Bubenheim, David

    1990-01-01

    Research in Controlled Ecological Life Support Systems (CELSS) conducted by NASA indicate that plant based systems are feasible candidates for human support in space. Ames has responsibility for research and development, systems integration and control, and space flight experiment portions of the CELSS program. Important areas for development of new methods and technologies are biomass production, waste processing, water purification, air revitalization, and food processing. For the plant system, the approach was to identify the flexibility and response time for the food, water, and oxygen production, and carbon dioxide consumption processes. Tremendous increases in productivity, compared with terrestrial agriculture, were realized. Waste processing research emphasizes recycle (transformation) of human wastes, trash, and inedible biomass to forms usable as inputs to the plant production system. Efforts to improve efficiency of the plant system, select new CELSS crops for a balanced diet, and initiate closed system research with the Crop Growth Research Chambers continue. The System Control and Integration program goal is to insure orchestrated system operation of the biological, physical, and chemical operation of the biological, physical, and chemical component processors of the CELSS. Space flight studies are planned to verify adequate operation of the system in reduced gravity or microgravity environments.

  17. 2016 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    Satyapal, Sunita [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-02-01

    In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  18. 2012 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    2012-12-01

    In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  19. 2015 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    Popovich, Neil

    2015-12-01

    In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  20. PME Guidelines for Program Development/Evaluation.

    Science.gov (United States)

    Dock, Stephen

    In a Program Development and Evaluation model, guidelines are presented for program directors at Delaware County Community College. Based on the premise that the process of developing programs is essentially that of evaluating programs, the model includes the following steps for both processes: (1) involve the appropriate publics; (2) identify…

  1. Development of gallium arsenide solar cells

    Science.gov (United States)

    1973-01-01

    The potential of ion implantation as a means to the development of high efficiency gallium arsenide solar cells is investigated. Summaries are included of the results of computer calculations of GaAs cell characteristics, based on a model which includes the effects of surface recombination, junction space-charge region recombination, and built-in fields produced by nonuniform doping in the region; of the fabrication technology developed under the program; and of the results of electrical and optical measurements on the samples produced during the program. It was determined that measured AMO efficiencies were more than a factor of two lower than the calculated values.

  2. Climate Change Fuel Cell Program

    Energy Technology Data Exchange (ETDEWEB)

    Paul Belard

    2006-09-21

    Verizon is presently operating the largest Distributed Generation Fuel Cell project in the USA. Situated in Long Island, NY, the power plant is composed of seven (7) fuel cells operating in parallel with the Utility grid from the Long Island Power Authority (LIPA). Each fuel cell has an output of 200 kW, for a total of 1.4 mW generated from the on-site plant. The remaining power to meet the facility demand is purchased from LIPA. The fuel cell plant is utilized as a co-generation system. A by-product of the fuel cell electric generation process is high temperature water. The heat content of this water is recovered from the fuel cells and used to drive two absorption chillers in the summer and a steam generator in the winter. Cost savings from the operations of the fuel cells are forecasted to be in excess of $250,000 per year. Annual NOx emissions reductions are equivalent to removing 1020 motor vehicles from roadways. Further, approximately 5.45 million metric tons (5 millions tons) of CO2 per year will not be generated as a result of this clean power generation. The project was partially financed with grants from the New York State Energy R&D Authority (NYSERDA) and from Federal Government Departments of Defense and Energy.

  3. Programmed Cell Death in Neurospora crassa

    Directory of Open Access Journals (Sweden)

    A. Pedro Gonçalves

    2014-01-01

    Full Text Available Programmed cell death has been studied for decades in mammalian cells, but simpler organisms, including prokaryotes, plants, and fungi, also undergo regulated forms of cell death. We highlight the usefulness of the filamentous fungus Neurospora crassa as a model organism for the study of programmed cell death. In N. crassa, cell death can be triggered genetically due to hyphal fusion between individuals with different allelic specificities at het loci, in a process called “heterokaryon incompatibility.” Chemical induction of cell death can also be achieved upon exposure to death-inducing agents like staurosporine, phytosphingosine, or hydrogen peroxide. A summary of the recent advances made by our and other groups on the discovery of the mechanisms and mediators underlying the process of cell death in N. crassa is presented.

  4. Hypothesis: patient with possible disturbance in programmed cell death

    NARCIS (Netherlands)

    Hennekam, R. C.; Cohen, M. M.

    1995-01-01

    Programmed cell death is a physiological process in mammalian development by which specific types of cells are eliminated, and, hence, is of fundamental importance in normal human embryogenesis. A patient is described with multiple congenital anomalies that may be explained by a disturbance of

  5. Chemical- and pathogen-induced programmed cell death in plants

    NARCIS (Netherlands)

    Iakimova, E.T.; Atanassov, A.; Woltering, E.J.

    2005-01-01

    This review focuses on recent update in the understanding of programmed cell death regarding the differences and similarities between the diverse types of cell death in animal and plant systems and describes the morphological and some biochemical determinants. The role of PCD in plant development

  6. Developing an Undergraduate Hospital Dentistry Program.

    Science.gov (United States)

    Gibson, G. B.; Swanson, A. E.

    1991-01-01

    The process used by the University of British Columbia to establish and improve an undergraduate hospital dentistry program is chronicled. The program's initial structure and objectives, use of student input for program improvement, and the success of the approach in developing an effective program are discussed. (MSE)

  7. UCLA Translational Biomarker Development Program (UTBD)

    Energy Technology Data Exchange (ETDEWEB)

    Czernin, Johannes [Univ. of California, Los Angeles, CA (United States)

    2014-09-01

    The proposed UTBD program integrates the sciences of diagnostic nuclear medicine and (radio)chemistry with tumor biology and drug development. UTBD aims to translate new PET biomarkers for personalized medicine and to provide examples for the use of PET to determine pharmacokinetic (PK) and pharmacodynamic (PD) drug properties. The program builds on an existing partnership between the Ahmanson Translational Imaging Division (ATID) and the Crump Institute of Molecular Imaging (CIMI), the UCLA Department of Chemistry and the Division of Surgical Oncology. ATID provides the nuclear medicine training program, clinical and preclinical PET/CT scanners, biochemistry and biology labs for probe and drug development, radiochemistry labs, and two cyclotrons. CIMI provides DOE and NIH-funded training programs for radio-synthesis (START) and molecular imaging (SOMI). Other participating entities at UCLA are the Department of Chemistry and Biochemistry and the Division of Surgical Oncology. The first UTBD project focuses on deoxycytidine kinase, a rate-limiting enzyme in nucleotide metabolism, which is expressed in many cancers. Deoxycytidine kinase (dCK) positive tumors can be targeted uniquely by two distinct therapies: 1) nucleoside analog prodrugs such as gemcitabine (GEM) are activated by dCK to cytotoxic antimetabolites; 2) recently developed small molecule dCK inhibitors kill tumor cells by starving them of nucleotides required for DNA replication and repair. Since dCK-specific PET probes are now available, PET imaging of tumor dCK activity could improve the use of two different classes of drugs in a wide variety of cancers.

  8. Evaluation on Foreign Language Development Program

    OpenAIRE

    KURNIAWAN, DODY

    2013-01-01

    Entering the global competition era, people need strategies to master foreign language. The objective of the evaluation on the foreign language development program in IHBS Junior High School (JHS) is to determine effectiveness of the program process and identify the problems that emerge. The evaluation model used is the CSE-UCLA which was initiated by Alkin. The evaluation was accomplished in several phases, namely: assessment program, planning program, implementation program, improvement pro...

  9. Plasma membrane changes during programmed cell deaths.

    Science.gov (United States)

    Zhang, Yingying; Chen, Xin; Gueydan, Cyril; Han, Jiahuai

    2018-01-01

    Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic and apoptotic cell death, respectively. As such, apoptosis is usually considered a non-inflammatory process while necrosis triggers inflammation. Recent studies on necroptosis and pyroptosis, two types of programmed necrosis, revealed that plasma membrane rupture is mediated by MLKL channels during necroptosis but depends on non-selective gasdermin D (GSDMD) pores during pyroptosis. Importantly, the morphology of dying cells executed by MLKL channels can be distinguished from that executed by GSDMD pores. Interestingly, it was found recently that secondary necrosis of apoptotic cells, a previously believed non-regulated form of cell lysis that occurs after apoptosis, can be programmed and executed by plasma membrane pore formation like that of pyroptosis. In addition, pyroptosis is associated with pyroptotic bodies, which have some similarities to apoptotic bodies. Therefore, different cell death programs induce distinctive reshuffling processes of the plasma membrane. Given the fact that the nature of released intracellular contents plays a crucial role in dying/dead cell-induced immunogenicity, not only membrane rupture or integrity but also the nature of plasma membrane breakdown would determine the fate of a cell as well as its ability to elicit an immune response. In this review, we will discuss recent advances in the field of apoptosis, necroptosis and pyroptosis, with an emphasis on the mechanisms underlying plasma membrane changes observed on dying cells and their implication in cell death-elicited immunogenicity.

  10. Fuel Cell Seminar, 1992: Program and abstracts

    Science.gov (United States)

    1992-03-01

    This year's theme, 'Fuel Cells: Realizing the Potential,' focuses on progress being made toward commercial manufacture and use of fuel cell products. Fuel cell power plants are competing for market share in some applications and demonstrations of market entry power plants are proceeding for additional applications. Development activity on fuel cells for transportation is also increasing; fuel cell products have potential in energy and transportation industries, with very favorable environmental impacts. This Seminar has the purpose of fostering communication by providing a forum for the international community interested in development, application, and business opportunities related fuel cells. Over 190 technical papers are included, the majority being processed for the data base.

  11. Fuel Cell Seminar, 1992: Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    This year`s theme, ``Fuel Cells: Realizing the Potential,`` focuses on progress being made toward commercial manufacture and use of fuel cell products. Fuel cell power plants are competing for market share in some applications and demonstrations of market entry power plants are proceeding for additional applications. Development activity on fuel cells for transportation is also increasing; fuel cell products have potential in energy and transportation industries, with very favorable environmental impacts. This Seminar has the purpose of fostering communication by providing a forum for the international community interested in development, application, and business opportunities related fuel cells. Over 190 technical papers are included, the majority being processed for the data base.

  12. Development of a discharge planning mentorship program.

    Science.gov (United States)

    Hansen, D C; Matt-Hensrud, N; Holland, D E; Severson, M A

    2000-01-01

    Discharge planning coordinators at a tertiary medical center developed a Discharge Planning Mentorship Program. The group established the educational program to support the autonomy of the staff primary nurse in the discharge planning component of professional practice. To establish the program, the discharge planning coordinators used the underlying principle of "CollaMentoach." The term is an acronym combining the three core concepts of collaboration, mentoring, and coaching. Program planning and marketing, participant selection, curriculum development, and curriculum evaluation are included to guide staff development specialists and nurse managers in the formulation of a program to enhance staff nurse discharge planning skills.

  13. Director of Program Area | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Job Summary The Director of a Program Area is accountable to the Vice President of the Program and Partnership Branch for providing strategic intelligence, ... Area; and; Contributes to policy development, planning, management and evaluation of program and administrative activities at the corporate and regional levels.

  14. Innovative Technology Development Program. Final summary report

    International Nuclear Information System (INIS)

    Beller, J.

    1995-08-01

    Through the Office of Technology Development (OTD), the U.S. Department of Energy (DOE) has initiated a national applied research, development, demonstration, testing, and evaluation program, whose goal has been to resolve the major technical issues and rapidly advance technologies for environmental restoration and waste management. The Innovative Technology Development (ITD) Program was established as a part of the DOE, Research, Development, Demonstration, Testing, and Evaluation (RDDT ampersand E) Program. The plan is part of the DOE's program to restore sites impacted by weapons production and to upgrade future waste management operations. On July 10, 1990, DOE issued a Program Research and Development Announcement (PRDA) through the Idaho Operations Office to solicit private sector help in developing innovative technologies to support DOE's clean-up goals. This report presents summaries of each of the seven projects, which developed and tested the technologies proposed by the seven private contractors selected through the PRDA process

  15. Innovative Technology Development Program. Final summary report

    Energy Technology Data Exchange (ETDEWEB)

    Beller, J.

    1995-08-01

    Through the Office of Technology Development (OTD), the U.S. Department of Energy (DOE) has initiated a national applied research, development, demonstration, testing, and evaluation program, whose goal has been to resolve the major technical issues and rapidly advance technologies for environmental restoration and waste management. The Innovative Technology Development (ITD) Program was established as a part of the DOE, Research, Development, Demonstration, Testing, and Evaluation (RDDT&E) Program. The plan is part of the DOE`s program to restore sites impacted by weapons production and to upgrade future waste management operations. On July 10, 1990, DOE issued a Program Research and Development Announcement (PRDA) through the Idaho Operations Office to solicit private sector help in developing innovative technologies to support DOE`s clean-up goals. This report presents summaries of each of the seven projects, which developed and tested the technologies proposed by the seven private contractors selected through the PRDA process.

  16. Advanced Cell Development and Degradation Studies

    Energy Technology Data Exchange (ETDEWEB)

    J. E. O' Brien; C. M. Stoots; J. S. Herring; R. C. O' Brien; K. G. Condie; M. Sohal; G. K. Housley; J. J. Hartvigsen; D. Larsen; G. Tao; B. Yildiz; V. Sharma; P. Singh; N. Petigny; T. L. Cable

    2010-09-01

    The Idaho National Laboratory (INL) has been researching the application of solid-oxide electrolysis cells for large-scale hydrogen production from steam over a temperature range of 800 to 900ºC. From 2003 – 2009, this work was sponsored by the DOE Nuclear Hydrogen Initiative (NHI). Starting in 2010, the HTE research program has been sponsored by the Next Generation Nuclear Plant (NGNP) program. HTSE research priorities in FY10 are centered on understanding and reducing cell and stack performance degradation to an acceptable level to advance the technology readiness level of HTSE and to justify further large-scale demonstration activities. This report provides a summary of our FY10 experimental program, which has been focused on advanced cell and stack development and degradation studies. Advanced cell and stack development activities are under way at five technology partners: MSRI, Versa Power, Ceramatec, NASA Glenn, and St. Gobain. Performance evaluation of the advanced technology cells and stacks has been performed by the technology partners, by MIT and the University of Connecticut and at the INL HTE Laboratory. Summaries of these development activities and test results are presented.

  17. Development of MOT Training Programs at DENSO

    Science.gov (United States)

    Suzuki, Takamasa; Utsumi, Hiroo; Imaeda, Makoto

    MOT Training Programs are developed at DENSO. The purpose of these programs is to improve the quality of our business leaders. These programs consist of Basic Technology Management Courses and Specialized Technology Courses. They adopt a lot of group discussions including in-house cases to help improve the abilities and skills of DENSO‧s engineers. This paper describes the education programs to acquire management skills and technological abilities as a business leader.

  18. Results of 200 KW fuel cell evaluation programs

    Energy Technology Data Exchange (ETDEWEB)

    Torrey, J.M.; Merten, G.P. [SAIC, San Diego, CA (United States); Binder, M.J. [Army Construction Engineering Research Labs., Champaign, IL (United States)] [and others

    1996-12-31

    Science Applications International Corporation (SAIC) has installed six monitoring systems on ONSI Corporation 200 kW phosphoric acid fuel cells. Three of the systems were installed for the U.S. Army Construction Engineering Research Laboratories (USACERL) which is coordinating the Department of Defense (DoD) fuel cell Demonstration Program and three were installed under a contract with the New York State Energy Research and Development Authority (NYSERDA). Monitoring of the three NYSERDA sites has been completed. Monitoring systems for the DoD fuel cells were installed in August, 1996 and thus no operating data was available at the time of this writing, but will be presented at the Fuel Cell Seminar. This paper will present the monitoring configuration and research approach for each program. Additionally, summary performance data is presented for the completed NYSERDA program.

  19. Developing Program Management Leadership for Acquisition Reform

    Science.gov (United States)

    2011-04-30

    mêçÅÉÉÇáåÖë= çÑ=íÜÉ= bfdeqe=^kkr^i=^`nrfpfqflk== obpb^o`e=pvjmlpfrj== qeropa^v=pbppflkp== slirjb ff Developing Program Management Leadership for...4. TITLE AND SUBTITLE Developing Program Management Leadership for Acquisition Reform 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...Developing Program  Management   Leadership   for Acquisition Reform    The 8th Annual Acquisition Research Symposium Panel #20: Investing in People

  20. Coastal nonpoint pollution control program: Program development and approval guidance

    International Nuclear Information System (INIS)

    1993-01-01

    The document, developed by NOAA and EPA, contains guidance for states in developing and implementing their coastal nonpoint pollutant source programs. It describes the requirements that must be met, including: the geographic scope of the program; the pollutant sources to be addressed; the types of management measures used; the establishment of critical areas; technical assistance, public participation, and administrative coordination; and, the process for program submission and Federal approval. The document also contains the criteria by which NOAA and EPA will review the states' submissions

  1. Hydrogen Fuel Cell Development in Columbia (SC)

    Energy Technology Data Exchange (ETDEWEB)

    Reifsnider, Kenneth

    2011-07-31

    This is an update to the final report filed after the extension of this program to May of 2011. The activities of the present program contributed to the goals and objectives of the Fuel Cell element of the Hydrogen, Fuel Cells and Infrastructure Technologies Program of the Department of Energy through five sub-projects. Three of these projects have focused on PEM cells, addressing the creation of carbon-based metal-free catalysts, the development of durable seals, and an effort to understand contaminant adsorption/reaction/transport/performance relationships at low contaminant levels in PEM cells. Two programs addressed barriers in SOFCs; an effort to create a new symmetrical and direct hydrocarbon fuel SOFC designs with greatly increased durability, efficiency, and ease of manufacturing, and an effort to create a multiphysics engineering durability model based on electrochemical impedance spectroscopy interpretations that associate the micro-details of how a fuel cell is made and their history of (individual) use with specific prognosis for long term performance, resulting in attendant reductions in design, manufacturing, and maintenance costs and increases in reliability and durability.

  2. Hydrogen Fuel Cell development in Columbia (SC)

    Energy Technology Data Exchange (ETDEWEB)

    Reifsnider, Kenneth [Univ. of South Carolina, Columbia, SC (United States); Chen, Fanglin [Univ. of South Carolina, Columbia, SC (United States); Popov, Branko [Univ. of South Carolina, Columbia, SC (United States); Chao, Yuh [Univ. of South Carolina, Columbia, SC (United States); Xue, Xingjian [Univ. of South Carolina, Columbia, SC (United States)

    2012-09-15

    This is an update to the final report filed after the extension of this program to May of 2011. The activities of the present program contributed to the goals and objectives of the Fuel Cell element of the Hydrogen, Fuel Cells and Infrastructure Technologies Program of the Department of Energy through five sub-projects. Three of these projects have focused on PEM cells, addressing the creation of carbon-based metal-free catalysts, the development of durable seals, and an effort to understand contaminant adsorption/reaction/transport/performance relationships at low contaminant levels in PEM cells. Two programs addressed barriers in SOFCs; an effort to create a new symmetrical and direct hydrocarbon fuel SOFC designs with greatly increased durability, efficiency, and ease of manufacturing, and an effort to create a multiphysics engineering durability model based on electrochemical impedance spectroscopy interpretations that associate the micro-details of how a fuel cell is made and their history of (individual) use with specific prognosis for long term performance, resulting in attendant reductions in design, manufacturing, and maintenance costs and increases in reliability and durability.

  3. Research Award: Innovation for Inclusive Development program

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    2011-09-12

    Research Award: Innovation for Inclusive Development program. Deadline: September 12, 2011. Note that all applications must be sent electronically. IDRC offers Research Awards annually to Canadians, permanent residents of. Canada, and citizens of developing countries pursuing master's or doctoral studies.

  4. Senior Program Specialist | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... Projects (RSPs) values up to $5-7 million;; Liaises with program colleagues in Ottawa and the regional offices on issues of program and project development and management;; Plays a leading role in the identifying, developing and managing IDRC's contacts with other international agencies and Canadian institutions; ...

  5. The DUPIC fuel development program in KAERI

    Energy Technology Data Exchange (ETDEWEB)

    Yang, M. S.; Park, H. S. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-07-01

    This study describes the DUPIC fuel development program in KAERI as follows; Burning spent PWR fuel again in CANDU by DUPIC, Compatibility with existing CANDU system, Feasibility of DUPIC fuel fabrication, Waste reduction, Safeguard ability, Economics of DUPIC fuel cycle, The DUPIC fuel development program, and International prospective. 5 refs., 10 figs.

  6. Programmed cell death: Superman meets Dr Death.

    Science.gov (United States)

    Meier, Pascal; Silke, John

    2003-12-01

    This year's Cold Spring Harbor meeting on programmed cell death (September 17-21, 2003), organised by Craig Thompson and Junying Yuan, was proof that the 'golden age' of research in this field is far from over. There was a flurry of fascinating insights into the regulation of diverse apoptotic pathways and unexpected non-apoptotic roles for some of the key apoptotic regulators and effectors. In addition to their role in cell death, components of the apoptotic molecular machinery are now known to also function in a variety of essential cellular processes, such as regulating glucose homeostasis, lipid metabolism, cell proliferation and differentiation.

  7. Solar cell materials developing technologies

    CERN Document Server

    Conibeer, Gavin J

    2014-01-01

    This book presents a comparison of solar cell materials, including both new materials based on organics, nanostructures and novel inorganics and developments in more traditional photovoltaic materials. It surveys the materials and materials trends in the field including third generation solar cells (multiple energy level cells, thermal approaches and the modification of the solar spectrum) with an eye firmly on low costs, energy efficiency and the use of abundant non-toxic materials.

  8. Nuclear Power Infrastructure Development Program: Korean Education Program

    International Nuclear Information System (INIS)

    Choi, Sung Yeol; Hwang, Il Soon; Kim, Si Hwan

    2009-01-01

    Many countries have decided nuclear power for next energy resources as one of the long-term energy supply options. IAEA projected nuclear power expansion up to 2030 reaching between 447 GWe and 691 GWe compared to 370 GWe and 2660 TWh at the end of 2006. Both low and high projection is accompanied with new nuclear power plant constructions respectively 178 and 357, about 11 units per year, and most new construction is in North America, the Far East, Eastern Europe, the Middle East, and Southeast Asia. During the last forty years, thirty three countries have established commercial nuclear power programs but only some of them have developed comprehensive and large scale peaceful nuclear power infrastructure. Although various cooperation and guidance program of nuclear power infrastructure, developing appropriate environment and infrastructure of nuclear power plant is still challenging problems for developing countries launching nuclear power program. With increasing the demand of safety and safeguard from international society, creating appropriate infrastructure becomes essential requirements in national nuclear power program. In the viewpoint of developing countries, without sufficient explanation and proper guidance, infrastructure could be seen only as another barrier in its nuclear power program. The importance of infrastructure development would be obscured by ostensible business and infrastructure program can result in increasing entering barriers to peaceful nuclear power application field without benefits to developing countries and international community. To avoid this situation by providing enough explanation and realistic case example and cooperate with the countries wanting to establish comprehensive nuclear power infrastructure in the peaceful applications, we are creating the education program of infrastructure development with basic guidelines of the IAEA infrastructure series and Korean experiences from least developed country to advanced country

  9. Program Development Tools and Infrastructures

    International Nuclear Information System (INIS)

    Schulz, M.

    2012-01-01

    Exascale class machines will exhibit a new level of complexity: they will feature an unprecedented number of cores and threads, will most likely be heterogeneous and deeply hierarchical, and offer a range of new hardware techniques (such as speculative threading, transactional memory, programmable prefetching, and programmable accelerators), which all have to be utilized for an application to realize the full potential of the machine. Additionally, users will be faced with less memory per core, fixed total power budgets, and sharply reduced MTBFs. At the same time, it is expected that the complexity of applications will rise sharply for exascale systems, both to implement new science possible at exascale and to exploit the new hardware features necessary to achieve exascale performance. This is particularly true for many of the NNSA codes, which are large and often highly complex integrated simulation codes that push the limits of everything in the system including language features. To overcome these limitations and to enable users to reach exascale performance, users will expect a new generation of tools that address the bottlenecks of exascale machines, that work seamlessly with the (set of) programming models on the target machines, that scale with the machine, that provide automatic analysis capabilities, and that are flexible and modular enough to overcome the complexities and changing demands of the exascale architectures. Further, any tool must be robust enough to handle the complexity of large integrated codes while keeping the user's learning curve low. With the ASC program, in particular the CSSE (Computational Systems and Software Engineering) and CCE (Common Compute Environment) projects, we are working towards a new generation of tools that fulfill these requirements and that provide our users as well as the larger HPC community with the necessary tools, techniques, and methodologies required to make exascale performance a reality.

  10. Yugoslavian Petroleum Refinery development program

    International Nuclear Information System (INIS)

    Ocic, Ozren

    1999-01-01

    This paper shows the analysis of the world petroleum industry development, being an important factor in planning the development of the Yugoslav petroleum industry and Pancevo Petroleum Refinery, as well. Then Yugoslav petroleum industry development is analysed, including the appropriate balances of crude oil production and crude oil products consumption. The way of realizing the basic targets are also proposed. Likewise, the analysis of the condition within West European refineries has been conducted, from the aspects of technology, energy consumption and environmental protection and the same analysis for Pancevo Petroleum Refinery has been presented, too. The analysis of the condition within the refineries in the European Union countries and comparing it with the condition within Pancevo Petroleum Refinery, makes it mainly possible to recognize the development programmes which should be realized in order that Pancevo Petroleum Refinery could reach the refining level of the EU countries. (Original)

  11. Development of Thymic Epithelial Cells

    DEFF Research Database (Denmark)

    Ulyanchenko, Svetlana; Vaidya, Harsh J.; O'Neill, Kathy E.

    2016-01-01

    The thymus is the primary lymphoid organ in which the T cell repertoire is generated. The complex cellularity of this organ is uniquely designed to facilitate T cell development: defects in thymus development or function can cause immunodeficiencies ranging from the absence of T cell-mediated imm......The thymus is the primary lymphoid organ in which the T cell repertoire is generated. The complex cellularity of this organ is uniquely designed to facilitate T cell development: defects in thymus development or function can cause immunodeficiencies ranging from the absence of T cell......-mediated immunity to broad-spectrum autoimmune disease. Peak thymus size and output occurs early in life, after which the thymus undergoes a natural process of involution. This results in the progressive loss of functional thymus tissue and correspondingly in decreased production of new naïve T cells with age...... - contributing to the diminished capacity of the aged immune system to adequately respond to new antigenic challenge. Age-related thymic involutions, together with the thymic involutions associated with cytotoxic therapies (e.g., radio- or chemotherapy), have raised interest in development of clinically useful...

  12. Programmed cell death and cell extrusion in rat duodenum

    DEFF Research Database (Denmark)

    Schauser, Kirsten; Larsson, Lars-Inge

    2005-01-01

    The small intestinal epithelium is continously renewed through a balance between cell division and cell loss. How this balance is achieved is uncertain. Thus, it is unknown to what extent programmed cell death (PCD) contributes to intestinal epithelial cell loss. We have used a battery...... of techniques detecting the events associated with PCD in order to better understand its role in the turnover of the intestinal epithelium, including modified double- and triple-staining techniques for simultaneously detecting multiple markers of PCD in individual cells. Only a partial correlation between TUNEL...... positivity for DNA fragmentation, c-jun phosphorylation on serine-63, positivity for activated caspase-3 and apoptotic morphology was observed. Our results show that DNA fragmentation does not invariable correlate to activation of caspase-3. Moreover, many cells were found to activate caspase-3 early...

  13. Current status of Westinghouse tubular solid oxide fuel cell program

    Energy Technology Data Exchange (ETDEWEB)

    Parker, W.G. [Westinghouse Science and Technology Center, Pittsburgh, PA (United States)

    1996-04-01

    In the last ten years the solid oxide fuel cell (SOFC) development program at Westinghouse has evolved from a focus on basic material science to the engineering of fully integrated electric power systems. Our endurance for this cell is 5 to 10 years. To date we have successfully operated at power for over six years. For power plants it is our goal to have operated before the end of this decade a MW class power plant. Progress toward these goals is described.

  14. Development of operation individual dosimetry programs in a developing country

    International Nuclear Information System (INIS)

    Sohrabi, M.

    1993-01-01

    Development of Operational Individual Dosimetry (OID) Programs is the principle rationale for any national radiation protection regulatory program in both developed and developing countries. Individual dosimetry for external radiation means making exposure measurements by equipment carried out on the persons or workers. An operational individual dosimetry (OID) program is defined as development of a program in an operational state to provide national or institutional dosimetry services; i.e. to cover routine, operational and special monitoring as defined by ICRP 35. The development of an OID program depends on many legal, administrative, psychological and technical factors such as number of institutions and radiation workers or persons to be monitored, radiation types and conditions of the workplaces, the state of related sciences and technologies, radiation protection infrastructure as regard to laws and regulations, the existence of qualified leader and manpower, desire to develop such a program, degree of self-dependency required, etc. Although development of such a program is fairly easy with a proper arrangement, some problems still exist in particular in a developing country. In this paper, the stated points and recommendations for development of OID programs in developing countries based on the experiences of the Islamic Republic of Iran and some other countries are presented and discussed. (author). 32 refs

  15. Specific Cell (Re-)Programming: Approaches and Perspectives.

    Science.gov (United States)

    Hausburg, Frauke; Jung, Julia Jeannine; David, Robert

    2018-01-01

    Many disorders are manifested by dysfunction of key cell types or their disturbed integration in complex organs. Thereby, adult organ systems often bear restricted self-renewal potential and are incapable of achieving functional regeneration. This underlies the need for novel strategies in the field of cell (re-)programming-based regenerative medicine as well as for drug development in vitro. The regenerative field has been hampered by restricted availability of adult stem cells and the potentially hazardous features of pluripotent embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Moreover, ethical concerns and legal restrictions regarding the generation and use of ESCs still exist. The establishment of direct reprogramming protocols for various therapeutically valuable somatic cell types has overcome some of these limitations. Meanwhile, new perspectives for safe and efficient generation of different specified somatic cell types have emerged from numerous approaches relying on exogenous expression of lineage-specific transcription factors, coding and noncoding RNAs, and chemical compounds.It should be of highest priority to develop protocols for the production of mature and physiologically functional cells with properties ideally matching those of their endogenous counterparts. Their availability can bring together basic research, drug screening, safety testing, and ultimately clinical trials. Here, we highlight the remarkable successes in cellular (re-)programming, which have greatly advanced the field of regenerative medicine in recent years. In particular, we review recent progress on the generation of cardiomyocyte subtypes, with a focus on cardiac pacemaker cells. Graphical Abstract.

  16. 78 FR 36520 - Rural Development Voucher Program

    Science.gov (United States)

    2013-06-18

    ... may be responsible for the full payment of rent. The Rural Development Voucher Program applies to any... contract must be executed before Rural Development Voucher payments can be made. Rural Development will use...- place. Also, in no event may the Rural Development Voucher payment exceed the actual tenant lease rent...

  17. Checkpoint Inhibition: Programmed Cell Death 1 and Programmed Cell Death 1 Ligand Inhibitors in Hodgkin Lymphoma.

    Science.gov (United States)

    Villasboas, Jose Caetano; Ansell, Stephen

    2016-01-01

    Hodgkin lymphoma (HL) is a lymphoid malignancy characterized by a reactive immune infiltrate surrounding relatively few malignant cells. In this scenario, active immune evasion seems to play a central role in allowing tumor progression. Immune checkpoint inhibitor pathways are normal mechanisms of T-cell regulation that suppress immune effector function following an antigenic challenge. Hodgkin lymphoma cells are able to escape immune surveillance by co-opting these mechanisms. The programmed cell death 1 (PD-1) pathway in particular is exploited in HL as the malignant Hodgkin and Reed-Sternberg cells express on their surface cognate ligands (PD-L1/L2) for the PD-1 receptor and thereby dampen the T-cell-mediated antitumoral response. Monoclonal antibodies that interact with and disrupt the PD-1:PD-L1/L2 axis have now been developed and tested in early-phase clinical trials in patients with advanced HL with encouraging results. The remarkable clinical activity of PD-1 inhibitors in HL highlights the importance of immune checkpoint pathways as therapeutic targets in HL. In this review, we discuss the rationale for targeting PD-1 and PD-L1 in the treatment of HL. We will evaluate the published clinical data on the different agents and highlight the safety profile of this class of agents. We discuss the available evidence on the use of biomarkers as predictors of response to checkpoint blockade and summarize the areas under active investigation in the use of PD-1/PD-L1 inhibitors for the treatment of HL.

  18. Assessing a GTA professional development program

    OpenAIRE

    Alicea-Muñoz, Emily; Masip, Joan Espar; Sullivan, Carol Subiño; Schatz, Michael F.

    2018-01-01

    For the last four years, the School of Physics at Georgia Tech have been preparing new Graduate Teaching Assistants (GTAs) through a program that integrates pedagogy, physics content, and professional development strategies. Here we discuss various assessments we have used to evaluate the program, among them surveys, GTA self-reporting, and end-of-semester student evaluations. Our results indicate that GTAs who participate in the program find its practical activities useful, feel better prepa...

  19. Alloy development for irradiation performance: program strategy

    International Nuclear Information System (INIS)

    Bloom, E.E.; Stiegler, J.O.; Wiffen, F.W.; Dalder, E.N.C.; Reuther, T.C.; Gold, R.E.; Holmes, J.J.; Kummer, D.L.; Nolfi, F.V.

    1978-01-01

    The objective of the Alloy Development for Irradiation Performance Program is the development of structural materials for use in the first wall and blanket region of fusion reactors. The goal of the program is a material that will survive an exposure of 40 MWyr/m 2 at a temperature which will allow use of a liquid-H 2 O heat transport system. Although the ultimate aim of the program is development of materials for commercial reactors by the end of this century, activities are organized to provide materials data for the relatively low performance interim machines that will precede commercial reactors

  20. Liquid Tin Anode Direct Coal Fuel Cell Final Program Report

    Energy Technology Data Exchange (ETDEWEB)

    Tao, Thomas

    2012-01-26

    This SBIR program will result in improved LTA cell technology which is the fundamental building block of the Direct Coal ECL concept. As described below, ECL can make enormous efficiency and cost contributions to utility scale coal power. This program will improve LTA cells for small scale power generation. As described in the Commercialization section, there are important intermediate military and commercial markets for LTA generators that will provide an important bridge to the coal power application. The specific technical information from this program relating to YSZ electrolyte durability will be broadly applicable SOFC developers working on coal based SOFC generally. This is an area about which very little is currently known and will be critical for successfully applying fuel cells to coal power generation.

  1. DOE Hydrogen and Fuel Cells Program Plan (September 2011)

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-09-01

    The Department of Energy Hydrogen and Fuel Cells Program Plan outlines the strategy, activities, and plans of the DOE Hydrogen and Fuel Cells Program, which includes hydrogen and fuel cell activities within the EERE Fuel Cell Technologies Program and the DOE offices of Nuclear Energy, Fossil Energy, and Science.

  2. Assessing an Academic Library Professional Development Program

    Science.gov (United States)

    Harker, Karen R.; O'Toole, Erin; Sassen, Catherine

    2018-01-01

    Professional development programs have been established in many academic libraries to support the research and scholarly activities of librarians. Continuous assessment can contribute to the sustainability and effectiveness of these programs. This study describes how measures of need, participation, satisfaction, and impact were employed to assess…

  3. Interactive Programming Support for Secure Software Development

    Science.gov (United States)

    Xie, Jing

    2012-01-01

    Software vulnerabilities originating from insecure code are one of the leading causes of security problems people face today. Unfortunately, many software developers have not been adequately trained in writing secure programs that are resistant from attacks violating program confidentiality, integrity, and availability, a style of programming…

  4. Examining Burma's Development: A Research Fellowship Program ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Regional Center for Social Science and Sustainable Development (RCSD) at Thailand's Chiang Mai University will manage the four-year program, which targets junior and mid-level academic and non-academic Burmese scholars. The program will ... LVIF announces five more funded projects. Eleven world-class ...

  5. Nutritional programming of reproductive development in heifers

    Science.gov (United States)

    Developmental programming is the biological process by which environmental factors influence the development of the organs and tissues in the body. There are two areas of developmental programming being investigated with applicability to beef production systems to improve performance of replacement...

  6. Programs and Research Advisor | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Analysis of trends and policy developments in the Sub-Saharan African Region in order to support IDRC's strategic plan and programming by: collating various information and data relevant to IDRC programs in the region through consultation of print and electronic sources and internal and external network of contacts; ...

  7. The US Liquid Metal Reactor Development Program

    International Nuclear Information System (INIS)

    Till, C.E.; Arnold, W.H.; Griffith, J.D.

    1988-01-01

    The US Liquid Metal Reactor Development Program has been restructured to take advantage of the opportunity today to carry out R and D on truly advanced reactor technology. The program gives particular emphasis to improvements to reactor safety. The new directions are based on the technology of the Integral Fast Reactor (IFR). Much of the basis for superior safety performance using IFR technology has been experimentally verified and aggressive programs continue in EBR-II and TREAT. Progress has been made in demonstrating both the metallic fuel and the new electrochemical processes of the IFR. The FFTF facility is converting to metallic fuel; however, FFTF also maintains a considerable US program in oxide fuels. In addition, generic programs are continuing in steam generator testing, materials development, and, with international cooperation, aqueous reprocessing. Design studies are carried out in conjunction with the IFR technology development program. In summary, the US maintains an active development program in Liquid Metal Reactor technology, and new directions in reactor safety are central to the program

  8. Programs | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    We help bring ideas to life. Our development programs support innovative solutions that improve global access to food, jobs, health, and technologies for growth. At IDRC, we have learned that the greatest benefit comes from focusing our investments to deliver large-scale impact. Our programs seek answers that drive ...

  9. Career Development in Language Education Programs

    Science.gov (United States)

    Shawer, Saad Fathy; Alkahtani, Saad Ali

    2013-01-01

    This study assesses the influence of a two-year language program evaluation on program directors and faculty career development. The study makes use of mixed-paradigms (positivism and qualitative interpretive), mixed-strategies (survey research and qualitative evaluation), one-way analysis of variance (ANOVA) and a post-hoc test of multiple…

  10. Lithium-Ion Cell Charge-Control Unit Developed

    Science.gov (United States)

    Reid, Concha M.; Manzo, Michelle A.; Buton, Robert M.; Gemeiner, Russel

    2005-01-01

    A lithium-ion (Li-ion) cell charge-control unit was developed as part of a Li-ion cell verification program. This unit manages the complex charging scheme that is required when Li-ion cells are charged in series. It enables researchers to test cells together as a pack, while allowing each cell to charge individually. This allows the inherent cell-to-cell variations to be addressed on a series string of cells and reduces test costs substantially in comparison to individual cell testing.

  11. Metra operations management development program : 2010 - 2015.

    Science.gov (United States)

    2016-11-04

    On behalf of the Urban Transportation Center, the University of Illinois (UIC) Great Cities Institute (GCI) provided curriculum development and training services to Metra for a workforce education program targeted to new and experienced managers. Met...

  12. Development of the French Photovoltaic Program

    Energy Technology Data Exchange (ETDEWEB)

    Brunet, M.

    1980-07-01

    The French photovoltaic research program is reviewed, listing companies involved. Projections of module and system costs are discussed. French industrial experience in photovoltaics is reviewed and several French systems operating in developing countries are mentioned. (MHR)

  13. Wetland Program Development Grants (WPDGs) Case Studies

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Wetland Grant Database (WGD) houses grant data for Wetland Program Development Grants (created by EPA in 1990 under the Clean Water Act Section 104(b)(3)...

  14. Geothermal Energy Research Development and Demonstration Program

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The Federal program's goal, strategy, plans, and achievements are summarized. In addition, geothermal development by state and local governments and, where available, by the private sector is described. (MHR)

  15. Development of a Decommissioning Certificate Program

    International Nuclear Information System (INIS)

    Morton, M. R.

    1999-01-01

    A Decommissioning Certificate Program has been developed at Washington State University Tri-Cities (WSU TC) in conjunction with Bechtel Hanford, Inc. (BHI), and the U.S. Department of Energy (DOE)to address the increasing need for qualified professionals to direct and manage decommissioning projects. The cooperative effort between academia, industry, and government in the development and delivery of this Program of education and training is described, as well as the Program's design to prepare students to contribute sooner, and at a higher level, to decommissioning projects

  16. Identifying Needs to Develop a PBL Staff Development Program

    Science.gov (United States)

    Coffin, Prarthana

    2013-01-01

    Staff development is a crucial element for educational intervention. Recognizing the importance of staff development, this study aims to pin-point suitable methodologies in developing a Problem-Based Learning (PBL) academic staff development program for a higher education institute where PBL has become an intervention alternative. The study aims…

  17. The impact of teaching development programs

    DEFF Research Database (Denmark)

    Rump, Camilla Østerberg; Christiansen, Frederik V; Trigwell, Keith

    University teaching development programs for academic staff typically have a range of different educational goals, ranging from gaining basic proficiency in teaching to the more fundamental goal of changing teachers’ conception of teaching towards student focused conceptions. In the current paper...... we shall explore the development of four dimensions of teacher development in a teaching development program (~10ECTS) at the University of Copenhagen. The two most important dimensions considered are the teachers’ conceptual change student focus (as measured by the Approaches to Teaching Inventory...

  18. OpenCL parallel programming development cookbook

    CERN Document Server

    Tay, Raymond

    2013-01-01

    OpenCL Parallel Programming Development Cookbook will provide a set of advanced recipes that can be utilized to optimize existing code. This book is therefore ideal for experienced developers with a working knowledge of C/C++ and OpenCL.This book is intended for software developers who have often wondered what to do with that newly bought CPU or GPU they bought other than using it for playing computer games; this book is also for developers who have a working knowledge of C/C++ and who want to learn how to write parallel programs in OpenCL so that life isn't too boring.

  19. Aire and T cell development.

    Science.gov (United States)

    Anderson, Mark S; Su, Maureen A

    2011-04-01

    In the thymus, developing T cells that react against self-antigens with high affinity are deleted in the process of negative selection. An essential component of this process is the display of self-antigens, including those whose expression are usually restricted to specific tissues, to developing T cells within the thymus. The Autoimmune Regulator (Aire) gene plays a crucial role in the expression of tissue specific self-antigens within the thymus, and disruption of Aire function results in spontaneous autoimmunity in both humans and mice. Recent advances have been made in our understanding of how Aire influences the expression of thousands of tissue-specific antigens in the thymus. Additional roles of Aire, including roles in chemokine and cytokine expression, have also been revealed. Factors important in the differentiation of Aire-expressing medullary thymic epithelial cells have been defined. Finally, the identity of antigen presenting cells in negative selection, including the role of medullary thymic epithelial cells in displaying tissue specific antigens to T cells, has also been clarified. Copyright © 2010 Elsevier Ltd. All rights reserved.

  20. Programming microbial population dynamics by engineered cell-cell communication.

    Science.gov (United States)

    Song, Hao; Payne, Stephen; Tan, Cheemeng; You, Lingchong

    2011-07-01

    A major aim of synthetic biology is to program novel cellular behavior using engineered gene circuits. Early endeavors focused on building simple circuits that fulfill simple functions, such as logic gates, bistable toggle switches, and oscillators. These gene circuits have primarily focused on single-cell behaviors since they operate intracellularly. Thus, they are often susceptible to cell-cell variations due to stochastic gene expression. Cell-cell communication offers an efficient strategy to coordinate cellular behavior at the population level. To this end, we review recent advances in engineering cell-cell communication to achieve reliable population dynamics, spanning from communication within single species to multispecies, from one-way sender-receiver communication to two-way communication in synthetic microbial ecosystems. These engineered systems serve as well-defined model systems to better understand design principles of their naturally occurring counterparts and to facilitate novel biotechnology applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Development of an earthquake catalog management program

    International Nuclear Information System (INIS)

    Eum, H. S.; Choi, I. K.

    1999-01-01

    Earthquake Catalog Management Program was developed for earthquake engineering and research. The program is composed of catalog database and application program. Catalog database currently has more than 720 catalog records from earthquake data recorded between 1994/12 and 1998/5 in korea. 17 parameters derived from earthquake data constitute each record. These parameters in database include information on the triggering events, recording station, and station specific recorded values. Catalog database also has information on 12 recording stations. Application program is a tool for accessing and managing the catalog database and recorded earthquake data files. The program provides various functions such as search, sort, display capabilities of catalog subset, file retrieval from hard disks or CD-ROM, file type conversion, and multiple output options including computer screen, printer, and disk files

  2. Fred P. Ellison and Portuguese Program Development

    Science.gov (United States)

    Milleret, Margo

    2016-01-01

    The written record of Ellison's involvement in Portuguese program development begins in 1964 when he became chairman of the Portuguese Language Development Group that met at several Modern Language Association meetings before being accepted by the American Association of Teachers of Spanish and Portuguese (AATSP) in 1967. The record ends in the…

  3. Developing a new bariatric surgery program.

    Science.gov (United States)

    Angstadt, John; Whipple, Oliver

    2007-11-01

    We initiated a new bariatric surgery program in February 2004. Before starting the program, we initiated a systemic planning process to design, develop, and implement a comprehensive, multidisciplinary program. Between May 2004 and June 2006, 178 patients underwent Roux-en-Y gastric bypass to treat morbid obesity at our institution. We have had no pulmonary emboli and no deaths. Twenty-one patients (11.8%) developed wound infection after surgery. Thirteen patients (7.3%) developed stenosis at the gastrojejunostomy. Five patients (2.8%) bled from the gastrojejunostomy. Four patients (2.2%) developed atelectasis. Three patients (1.6%) developed an internal hernia after surgery. One patient (0.5%) developed deep venous thrombosis. Two patients (1.1%) developed small bowel obstruction from adhesions. One patient developed a leak (0.6%). By 6 months after surgery, our patients have lost an average of 85 pounds (53% excess weight loss). By 12 months, they have lost an average of 104 pounds (65% excess weight loss). A focused effort to reduce infection has dropped our wound infection rate to 0 per cent in the past 6 months. Our results indicate that with proper planning, it is possible to initiate a new program and achieve excellent outcomes. Proper planning, systematic implementation, and a focus on patient education are critical to success.

  4. Pilot Project - National Development Research Program (Honduras ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The idea for a National Research and Training Program (PRIDE, in Spanish) emerged from the IDRC-supported project, "100133 Building Learning Systems for Honduran Development." This grant will support a pilot version of PRIDE consisting of two calls for proposals. The first will focus on poverty and development ...

  5. National Program Plan Fuel Cells in Transportation. Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    Fuel cells are being developed for application in the transportation sector because they will convert hydrogen to electric power at high efficiencies with virtually no detrimental environmental impact. To realize these energy, environmental, and economic benefits, developers of FCVs need to (1) reduce the size and weight of current designs, (2) develop fuel cell propulsion systems with rapid start-up and greater load-following capability, (3) reduce system cost and/or improve performance, and (4) utilize alternative fuels to a large extent. This Plan addresses the FCV-related requirements of the Energy Act, describing a development program for light- and heavy-duty propulsion systems, a basic R&D program on fuel cell technology that is separate from, but feeds into, the system development activities, and supporting analyses. Implementation of the Program Plan by means of industry/government alliances will accelerate the commercialization of FCVs. In the long term, the successful deployment of large numbers of FCVs promises to eliminate the transportation sector as a major contributor to the nation`s environmental problems.

  6. 78 FR 44575 - Sickle Cell Disease Treatment Demonstration Program

    Science.gov (United States)

    2013-07-24

    ... Extension: Sickle Cell Disease Treatment Demonstration Program (U1E) Awards to Three Currently Funded... the Sickle Cell Disease Treatment Demonstration Program. Three of these awards will end on August 31.... Justification: The Sickle Cell Disease Treatment Demonstration Program provides grants to evaluate the use of...

  7. Development of a training assurance program

    International Nuclear Information System (INIS)

    Palchinsky, J.; Waylett, W.J. Jr.

    1987-01-01

    The nuclear industry has made a significant commitment to improve training through the implementation of accredited performance-based training programs. Senior management expects that human performance will improve as a result of significant resource allocations. How do they know if training is effective in achieving improved human performance? Florida Power and Light Company is developing a Training Assurance Program to track indicators of training performance and future trends. Integrating the company's Quality Improvement Program processes with systematic training processes is resulting in personnel functioning in a proactive mode and increased customer satisfaction with training performance

  8. Disease management: program design, development, and implementation.

    Science.gov (United States)

    Harvey, N; DePue, D M

    1997-06-01

    Disease management is an emerging approach to patient management, customer satisfaction, and cost containment that comprises disease modeling; patient segmentation and risk assessment; clinical protocols; and wellness, self-management, and education. Implementing a disease management program poses significant challenges to healthcare organizations. To successfully implement a disease management program, a tightly integrated continuum of care, sophisticated information systems, and disease management support systems must be in place. Strategic partnerships with outside vendors may speed program implementation and provide opportunities to develop risk-sharing relationships.

  9. Advanced fuel cell development in the United States

    International Nuclear Information System (INIS)

    Ackerman, J.P.

    1984-01-01

    Both molten carbonate and solid oxide fuel cells are being developed in the United States to complement and/or supplant phosphoric acid cells for commercial and utility use. This paper described the two technologies and the programs for their development

  10. High Temperature Solid Oxide Fuel Cell Generator Development

    Energy Technology Data Exchange (ETDEWEB)

    Joseph Pierre

    2007-09-30

    This report describes the results of the tubular SOFC development program from August 22, 1997 to September 30, 2007 under the Siemens/U.S. Department of Energy Cooperative Agreement. The technical areas discussed include cell manufacturing development, cell power enhancement, SOFC module and system cost reduction and technology advancement, and our field unit test program. Whereas significant progress has been made toward commercialization, significant effort remains to achieve our cost, performance and reliability targets for successful commercialization.

  11. Transuranic waste management program waste form development

    International Nuclear Information System (INIS)

    Bennett, W.S.; Crisler, L.R.

    1981-01-01

    To ensure that all technology necessary for long term management of transuranic (TRU) wastes is available, the Department of Energy has established the Transuranic Waste Management Program. A principal focus of the program is development of waste forms that can accommodate the very diverse TRU waste inventory and meet geologic isolation criteria. The TRU Program is following two approaches. First, decontamination processes are being developed to allow removal of sufficient surface contamination to permit management of some of the waste as low level waste. The other approach is to develop processes which will allow immobilization by encapsulation of the solids or incorporate head end processes which will make the solids compatible with more typical waste form processes. The assessment of available data indicates that dewatered concretes, synthetic basalts, and borosilicate glass waste forms appear to be viable candidates for immobilization of large fractions of the TRU waste inventory in a geologic repository

  12. Development of endosperm transfer cells in barley

    Directory of Open Access Journals (Sweden)

    Johannes eThiel

    2014-03-01

    Full Text Available Endosperm transfer cells (ETCs are positioned at the intersection of maternal and filial tissues in seeds of cereals and represent a bottleneck for apoplasmic transport of assimilates into the endosperm. Endosperm cellularization starts at the maternal-filial boundary and generates the highly specialized ETCs. During differentiation barley ETCs develop characteristic flange-like wall ingrowths to facilitate effective nutrient transfer. A comprehensive morphological analysis depicted distinct developmental time points in establishment of transfer cell morphology and revealed intracellular changes possibly associated with cell wall metabolism. Embedded inside the grain, ETCs are barely accessible by manual preparation. To get tissue-specific information about ETC specification and differentiation, laser microdissection(LM-based methods were used for transcript and metabolite profiling. Transcriptome analysis of ETCs at different developmental stages by microarrays indicated activated gene expression programs related to control of cell proliferation and cell shape, cell wall and carbohydrate metabolism reflecting the morphological changes during early ETC development. Transporter genes reveal distinct expression patterns suggesting a switch from active to passive modes of nutrient uptake with the onset of grain filling. Tissue-specific RNA-seq of the differentiating ETC region from the syncytial stage until functionality in nutrient transfer identified a high number of novel transcripts putatively involved in ETC differentiation. An essential role for two-component signaling (TCS pathways in transfer cell development of barley emerged from this analysis. Correlative data provide evidence for ABA and ethylene influences on ETC differentiation and hint at a crosstalk between hormone signal transduction and TCS phosphorelays. Collectively, the data expose a comprehensive view on ETC development, associated pathways and identified candidate genes for

  13. Advanced Digital Controller Development Program, Task I.

    Science.gov (United States)

    1982-07-01

    digital controller through an electra-hydraulic servo valve ( EHSV ) and a position transducer. A pair of hydraulic cylinders will actuate a bell crank...AD-A129 269 ADVANCED DIGITAL CONTROLLER DEVELOPMENT PROGRAM TASK 1 1/1 ()GENERAL MOTORS CORP INDIANAPOLIS IN DETROIT DIESEL ALLISON D0. d H HUNTER JL...BUREAU OF S IANDARDS I-63 A I-16 2 I "-I [ I1 I ? I I I I II I I AFWAL-TR-82-2047 ’ Advanced Digital Controller < Development Program, Task I Detroit

  14. Program of scientific investigations and development of solid-oxide fuel cells (SOFC) in VIITF proposals on scientific and technical collaboration and SOFC commercialization

    Energy Technology Data Exchange (ETDEWEB)

    Kleschev, Yu.N.; Chulharev, V.F.

    1996-04-01

    Investigations being performed at VNIITF covers the whole cycle of solid oxide fuel cell manufacturing. This report describes the main directions of investigations in materials, technologies, and commercialization.

  15. HUMID AIR TURBINE CYCLE TECHNOLOGY DEVELOPMENT PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    Richard Tuthill

    2002-07-18

    The Humid Air Turbine (HAT) Cycle Technology Development Program focused on obtaining HAT cycle combustor technology that will be the foundation of future products. The work carried out under the auspices of the HAT Program built on the extensive low emissions stationary gas turbine work performed in the past by Pratt & Whitney (P&W). This Program is an integral part of technology base development within the Advanced Turbine Systems Program at the Department of Energy (DOE) and its experiments stretched over 5 years. The goal of the project was to fill in technological data gaps in the development of the HAT cycle and identify a combustor configuration that would efficiently burn high moisture, high-pressure gaseous fuels with low emissions. The major emphasis will be on the development of kinetic data, computer modeling, and evaluations of combustor configurations. The Program commenced during the 4th Quarter of 1996 and closed in the 4th Quarter of 2001. It teamed the National Energy Technology Laboratory (NETL) with P&W, the United Technologies Research Center (UTRC), and a subcontractor on-site at UTRC, kraftWork Systems Inc. The execution of the program started with bench-top experiments that were conducted at UTRC for extending kinetic mechanisms to HAT cycle temperature, pressure, and moisture conditions. The fundamental data generated in the bench-top experiments was incorporated into the analytical tools available at P&W to design the fuel injectors and combustors. The NETL then used the hardware to conduct combustion rig experiments to evaluate the performance of the combustion systems at elevated pressure and temperature conditions representative of the HAT cycle. The results were integrated into systems analysis done by kraftWork to verify that sufficient understanding of the technology had been achieved and that large-scale technological application and demonstration could be undertaken as follow-on activity. An optional program extended the

  16. Development of alkaline fuel cells.

    Energy Technology Data Exchange (ETDEWEB)

    Hibbs, Michael R.; Jenkins, Janelle E.; Alam, Todd Michael; Janarthanan, Rajeswari; Horan, James L.; Caire, Benjamin R.; Ziegler, Zachary C.; Herring, Andrew M.; Yang, Yuan; Zuo, Xiaobing; Robson, Michael H.; Artyushkova, Kateryna; Patterson, Wendy; Atanassov, Plamen Borissov

    2013-09-01

    This project focuses on the development and demonstration of anion exchange membrane (AEM) fuel cells for portable power applications. Novel polymeric anion exchange membranes and ionomers with high chemical stabilities were prepared characterized by researchers at Sandia National Laboratories. Durable, non-precious metal catalysts were prepared by Dr. Plamen Atanassovs research group at the University of New Mexico by utilizing an aerosol-based process to prepare templated nano-structures. Dr. Andy Herrings group at the Colorado School of Mines combined all of these materials to fabricate and test membrane electrode assemblies for single cell testing in a methanol-fueled alkaline system. The highest power density achieved in this study was 54 mW/cm2 which was 90% of the project target and the highest reported power density for a direct methanol alkaline fuel cell.

  17. Programmed Cell Death in Plants: An Overview.

    Science.gov (United States)

    Locato, Vittoria; De Gara, Laura

    2018-01-01

    Programmed cell death (PCD) is a controlled mechanism that eliminates specific cells under developmental or environmental stimuli. All organisms-from bacteria to multicellular eukaryotes-have the ability to induce PCD in selected cells. Although this process was first identified in plants, the interest in deciphering the signaling pathways leading to PCD strongly increased when evidence came to light that PCD may be involved in several human diseases. In plants, PCD activation ensures the correct occurrence of growth and developmental processes, among which embryogenesis and differentiation of tracheary elements. PCD is also part of the defense responses activated by plants against environmental stresses, both abiotic and biotic.This chapter gives an overview of the roles of PCD in plants as well as the problems arising in classifying different kinds of PCD according to defined biochemical and cellular markers, and in comparison with the various types of PCD occurring in mammal cells. The importance of understanding PCD signaling pathways, with their elicitors and effectors, in order to improve plant productivity and resistance to environmental stresses is also taken into consideration.

  18. The impact of teaching development programs

    DEFF Research Database (Denmark)

    Rump, Camilla Østerberg; Christiansen, Frederik V; Trigwell, Keith

    University teaching development programs for academic staff typically have a range of different educational goals, ranging from gaining basic proficiency in teaching to the more fundamental goal of changing teachers’ conception of teaching towards student focused conceptions. In the current paper...... we shall explore the development of four dimensions of teacher development in a teaching development program (~10ECTS) at the University of Copenhagen. The two most important dimensions considered are the teachers’ conceptual change student focus (as measured by the Approaches to Teaching Inventory......), and the development of teachers’ self-efficacy beliefs with respect to teaching (as measured by a modified version of the Science Teaching Efficacy Belief Instrument). We find significant improvements with respect to both of these dimensions in several recent courses. No significant changes are found with respect...

  19. Developing an employee cardiovascular fitness program.

    Science.gov (United States)

    Perryman, B E

    1980-01-01

    Employee fitness programs, which have become increasingly popular in industrial settings, particularly over the past decade, are now also gaining favour in the hospital environment. Whereas employers are interested in the positive relationships between physical fitness, absenteeism and work performance, employees, as a result of participation in fitness activities, enjoy a more positive outlook on life. This paper discusses several points which might be considered during the development of a fitness program for employees, such as: persuading administrators of the need; generating employee interest; pre-testing participants; and actual program planning. The organization of the program -- it frequency and duration, and the warm-up, training and cool-down periods -- is also outlined.

  20. Development of portable fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Nakatou, K.; Sumi, S.; Nishizawa, N. [Sanyo Electric Co., Ltd., Osaka (Japan)

    1996-12-31

    Sanyo Electric has been concentrating on developing a marketable portable fuel cell using phosphoric acid fuel cells (PAFC). Due to the fact that this power source uses PAFC that operate at low temperature around 100{degrees} C, they are easier to handle compared to conventional fuel cells that operate at around 200{degrees} C , they can also be expected to provide extended reliable operation because corrosion of the electrode material and deterioration of the electrode catalyst are almost completely nonexistent. This power source is meant to be used independently and stored at room temperature. When it is started up, it generates electricity itself using its internal load to raise the temperature. As a result, the phosphoric acid (the electolyte) absorbs the reaction water when the temperature starts to be raised (around room temperature). At the same time the concentration and volume of the phosphoric acid changes, which may adversely affect the life time of the cell. We have studied means for starting, operating PAFC stack using methods that can simply evaluate changes in the concentration of the electrolyte in the stack with the aim of improving and extending cell life and report on them in this paper.

  1. Development of an MPI benchmark program library

    Energy Technology Data Exchange (ETDEWEB)

    Uehara, Hitoshi

    2001-03-01

    Distributed parallel simulation software with message passing interfaces has been developed to realize large-scale and high performance numerical simulations. The most popular API for message communication is an MPI. The MPI will be provided on the Earth Simulator. It is known that performance of message communication using the MPI libraries gives a significant influence on a whole performance of simulation programs. We developed an MPI benchmark program library named MBL in order to measure the performance of message communication precisely. The MBL measures the performance of major MPI functions such as point-to-point communications and collective communications and the performance of major communication patterns which are often found in application programs. In this report, the description of the MBL and the performance analysis of the MPI/SX measured on the SX-4 are presented. (author)

  2. Professional Development Programs for Teachers of English

    Directory of Open Access Journals (Sweden)

    Singgih Widodo

    2016-02-01

    Full Text Available Well-planned programs based on the needs for professional development of teachers are strongly needed to enhance the teaching-staff improvement.The impact of teacher improvement will effect the students learning and school achievement. This paper aims at raising awareness of English teachers to upgrade themselves as autonomous learners as well as researchers and broaden their horizon for stepping the ladder-career of their profession. For that purpose, a survey as reported here aimed to identify the needs of individual English teachers and the preferred programs for professional development. The findings indicated that the 36 teachers involved needed teacher training, teacher association, teacher materials, continuing education, and interschool visit and that teacher training was the most well known program among teachers.

  3. Synthetic RNA Controllers for Programming Mammalian Cell Fate and Function

    Science.gov (United States)

    2015-11-04

    Final report for “Synthetic RNA controllers for programming mammalian cell fate and function” Principal Investigator: Christina D. Smolke...SUBTITLE Synthetic RNA controllers for programming mammalian cell fate and function 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18   2 Synthetic RNA controllers for programming mammalian cell fate and function Task 1

  4. New Insights on Schwann Cell Development

    Science.gov (United States)

    Monk, Kelly R.; Feltri, M. Laura; Taveggia, Carla

    2015-01-01

    In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact with axons throughout development. Schwann cells generate the insulating myelin sheath and provide vital trophic support to the neurons that they ensheathe. Schwann cell precursors arise from neural crest progenitor cells, and a highly ordered developmental sequence controls the progression of these cells to become mature myelinating or non-myelinating Schwann cells. Here, we discuss both seminal discoveries and recent advances in our understanding of the molecular mechanisms that drive Schwann cell development and myelination with a focus on cell-cell and cell-matrix signaling events. PMID:25921593

  5. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    CIEE`s second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director`s discretionary research, and exploratory research will also be featured in this report.

  6. REPORT ON MDTA INSTITUTIONAL TRAINING PROGRAM DEVELOPMENTS.

    Science.gov (United States)

    Bureau of Employment Security (DOL), Washington, DC.

    THE DATA ON MANPOWER DEVELOPMENT TRAINING ACT (MDTA) PROGRAM ACCOMPLISHMENTS DURING 1964 AND 1965 REFLECT THE INCREASING EMPHASIS ON ASSISTING DISADVANTAGED TRAINEES SUCH AS JOBLESS TEENAGERS, NONWHITES, AND PERSONS OF LIMITED EDUCATIONAL ATTAINMENT. ALMOST HALF OF THE 321,456 ENROLLEES RECEIVED TRAINING IN THE SKILLED AND SEMI-SKILLED CATEGORIES,…

  7. Program Leader | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... range from 30 to 100 activities with a value of $10 to 20 million;; Liaises with the DPA and Regional Directors (RDs) (i.e. senior management) on issues of program and project development and management;; Is responsible for the PI team's and IDRC's contacts with other international agencies and Canadian institutions; ...

  8. Devolving Programs (2009) | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-04-25

    Apr 25, 2016 ... As IDRC is pursuing the devolution of two program initiatives, senior management requested that past experience with devolution be examined to see what lessons could be gleaned. The primary objective of this evaluation is to develop guiding principles that could inform future devolution practice.

  9. The Mentoring Experience: Leadership Development Program Perspectives

    Science.gov (United States)

    Lamm, Kevan W.; Sapp, Rochelle; Lamm, Alexa J.

    2017-01-01

    Using a semi-structured interview approach, ten mentors from a leadership development program focused on building leaders in Colleges of Agriculture and Life Sciences across the nation provided insights regarding their mentoring method, process, and experiences. Mentors interviewed agreed the mentoring process was beneficial for themselves as well…

  10. Counter Trafficking System Development "Analysis Training Program"

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Dennis C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2010-12-01

    This document will detail the training curriculum for the Counter-Trafficking System Development (CTSD) Analysis Modules and Lesson Plans are derived from the United States Military, Department of Energy doctrine and Lawrence Livermore National Laboratory (LLNL), Global Security (GS) S Program.

  11. Career Development Programs in Fortune 500 Firms.

    Science.gov (United States)

    Keller, Jack; Piotrowski, Chris

    Career development programs (CDPs) are a rather recent area of study in organizational and industrial psychology. The present study investigated the nature and evaluation of CDPs in Fortune 500 firms. Data were obtained by a mailed questionnaire completed by the firms' human resources directors. Of the 500 companies surveyed, only those 50 that…

  12. Senior Program Specialist | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Primary Duties or Responsibilities 1. ... North, and with the international donor community; and; Keeps up to date with, and contributes to, research and current developments in the disciplines/areas covered by the CRVS Initiative/MCH Program and in the regions where the work is conducted and at the international level.

  13. Programmed cell death - strategy for maintenance cellular organisms homeostasis.

    Science.gov (United States)

    Godlewski, Mirosław; Kobylińska, Agnieszka

    2016-12-20

    Programmed cell death (PCD) is a cellular suicide process, commonly found in organisms, that is important for elimination unnecessary and damaged cells during development and adaptation to abiotic and biotic environmental stresses. PCD is a complex and precise, genetically controlled cellular process, in opposite to non-programmed death, necrosis, in which cells are "killed" by strong abiotic factors. This article shows: the occurrence of PCD during animals and plants ontogenesis, classification of cell death types in these organisms with description of autophagy, apoptosis and necrotic cell death and with discussion on plant cell death by apoptosis. The role of Bcl-2 protein and other proteins involved in the regulation of apoptosis induction and detection in the plant's (whose genomes do not encode these proteins) proteins of analogous function is also discussed. The paper also presents the effects of the expression of animals pro- and anti-apoptotic genes transformed into yeast and plants, and the use of transformed yeast as model to identify in cDNA libraries animal and plant genes involved in regulation of the induction and course of the PCD.

  14. Programmed cell death – strategy for maintenance cellular organisms homeostasis

    Directory of Open Access Journals (Sweden)

    Mirosław Godlewski

    2016-12-01

    Full Text Available Programmed cell death (PCD is a cellular suicide process, commonly found in organisms, that is important for elimination unnecessary and damaged cells during development and adaptation to abiotic and biotic environmental stresses. PCD is a complex and precise, genetically controlled cellular process, in opposite to non-programmed death, necrosis, in which cells are “killed” by strong abiotic factors. This article shows: the occurrence of PCD during animals and plants ontogenesis, classification of cell death types in these organisms with description of autophagy, apoptosis and necrotic cell death and with discussion on plant cell death by apoptosis. The role of Bcl-2 protein and other proteins involved in the regulation of apoptosis induction and detection in the plant’s (whose genomes do not encode these proteins proteins of analogous function is also discussed. The paper also presents the effects of the expression of animals pro- and anti-apoptotic genes transformed into yeast and plants, and the use of transformed yeast as model to identify in cDNA libraries animal and plant genes involved in regulation of the induction and course of the PCD.

  15. Program of scientific investigations and development of solid-oxide fuel cells (SOFC) in VNIITF. Proposals on scientific and technical collaboration and SOFC commercialization

    Energy Technology Data Exchange (ETDEWEB)

    Kleschev, Yu.N.; Chukharev, V.F.

    1996-04-01

    This paper describes proposals on scientific and technical collaborations pertaining to solid oxide fuel cell commercialization. Topics included for discussion are: materials research and manufacture; market estimation and cost; directions of collaboration; and project of proposals on joint enterprise creation.

  16. Identifying needs to develop a PBL staff development program

    Directory of Open Access Journals (Sweden)

    Prarthana Coffin

    2013-08-01

    Full Text Available Staff development is a crucial element for educational intervention. Recognizing the importance of staff development, this study aims to pin-point suitable methodologies in developing a Problem-Based Learning (PBL academic staff development program for a higher education institute where PBL has become an intervention alternative. The study aims to answer the following research questions 1 how can university academic staff be assisted to acquire pedagogical competences for an initiative of the implementation of PBL curriculum? 2 What kinds of support do university academic staff need in order to maintain PBL implementation? Through a combination of a literature review, interviews with 6 PBL experts which emphasize the importance of PBL facilitators, and document analysis of reflection notes from 18 trainees of a PBL workshop, this study will produce a guideline in developing a PBL Academic Staff Development Program for an institute wishes to implement and retain PBL as the education strategy.

  17. Multiple mediators of plant programmed cell death : interplay of conserved cell death mechanisms and plant-specific regulators

    NARCIS (Netherlands)

    Hoeberichts, F.A.; Woltering, E.J.

    2002-01-01

    Programmed cell death (PCD) is a process aimed at the removal of redundant, misplaced, or damaged cells and it is essential to the development and maintenance of multicellular organisms. In contrast to the relatively well-described cell death pathway in animals, often referred to as apoptosis,

  18. Bioenergy Feedstock Development Program Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.

    2001-02-09

    The U.S. Department of Energy's (DOE's) Bioenergy Feedstock Development Program (BFDP) at Oak Ridge National Laboratory (ORNL) is a mission-oriented program of research and analysis whose goal is to develop and demonstrate cropping systems for producing large quantities of low-cost, high-quality biomass feedstocks for use as liquid biofuels, biomass electric power, and/or bioproducts. The program specifically supports the missions and goals of DOE's Office of Fuels Development and DOE's Office of Power Technologies. ORNL has provided technical leadership and field management for the BFDP since DOE began energy crop research in 1978. The major components of the BFDP include energy crop selection and breeding; crop management research; environmental assessment and monitoring; crop production and supply logistics operational research; integrated resource analysis and assessment; and communications and outreach. Research into feedstock supply logistics has recently been added and will become an integral component of the program.

  19. Laboratory Directed Research ampersand Development Program

    International Nuclear Information System (INIS)

    Ogeka, G.J.; Romano, A.J.

    1993-12-01

    At Brookhaven National Laboratory the Laboratory Directed Research and Development (LDRD) Program is a discretionary research and development tool critical in maintaining the scientific excellence and vitality of the laboratory. It is also a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence, and a means to address national needs, within the overall mission of the Department of Energy and Brookhaven National Laboratory. This report summarizes research which was funded by this program during fiscal year 1993. The research fell in a number of broad technical and scientific categories: new directions for energy technologies; global change; radiation therapies and imaging; genetic studies; new directions for the development and utilization of BNL facilities; miscellaneous projects. Two million dollars in funding supported 28 projects which were spread throughout all BNL scientific departments

  20. Impact of a student leadership development program.

    Science.gov (United States)

    Chesnut, Renae; Tran-Johnson, Jennifer

    2013-12-16

    To assess the effectiveness of the Student Leadership Development Series (SLDS), an academic-year--long, co-curricular approach to developing leadership skills in pharmacy students. Participants met once per month for activities and a college-wide guest speaker session. Students also completed monthly forms regarding what they had learned, participated in poster presentations, and created a personal leadership platform. One hundred twenty-three students participated in the program between 2008 and 2013. On monthly evaluation forms and a summative evaluation, students indicated that the program helped them feel prepared for leadership opportunities and increased their desire to pursue leadership. They valued interacting with pharmacy leaders from the community and learning how they could distinguish themselves as leaders. The SLDS provided pharmacy students with an opportunity to explore personal leadership styles and develop broader understanding of leadership, and increased their desire to pursue leadership positions in the future.

  1. Impact of a Student Leadership Development Program

    Science.gov (United States)

    Tran-Johnson, Jennifer

    2013-01-01

    Objective. To assess the effectiveness of the Student Leadership Development Series (SLDS), an academic-year--long, co-curricular approach to developing leadership skills in pharmacy students. Design. Participants met once per month for activities and a college-wide guest speaker session. Students also completed monthly forms regarding what they had learned, participated in poster presentations, and created a personal leadership platform. Assessment. One hundred twenty-three students participated in the program between 2008 and 2013. On monthly evaluation forms and a summative evaluation, students indicated that the program helped them feel prepared for leadership opportunities and increased their desire to pursue leadership. They valued interacting with pharmacy leaders from the community and learning how they could distinguish themselves as leaders. Conclusions. The SLDS provided pharmacy students with an opportunity to explore personal leadership styles and develop broader understanding of leadership, and increased their desire to pursue leadership positions in the future. PMID:24371349

  2. Integrated rural development programs: a skeptical perspective.

    Science.gov (United States)

    Ruttan, V W

    1975-11-01

    In examining integrated rural development programs the question that arises is why is it possible to identify several relatively successful small-scale or pilot rural development projects yet so difficult to find examples of successful rural development programs. 3 bodies of literature offer some insight into the morphology of rural development projects, programs, and processes: the urban-industrial impact hypothesis; the theory of induced technical change; and the new models of institutional change that deal with institution building and the economics of bureaucratic behavior. The urban-industrial impact hypothesis helps in the clarification of the relationships between the development of rural areas and the development of the total society of which rural areas are a part. It is useful in understanding the spatial dimensions of rural development where rural development efforts are likely to be most successful. Formulation of the hypothesis generated a series of empirical studies designed to test its validity. The effect of these studies has been the development of a rural development model in which the rural community is linked to the urban-industrial economy through a series of market relationships. Both the urban economy's rate of growth and the efficiency of the intersector product and factor markets place significant constraints on the possibilities of rural area development. It is not possible to isolate development processes in the contemporary rural community in a developing society from development processes in the larger society. The induced technical change theory provides a guide as to what must be done to gain access to efficient sources of economic growth, the new resources and incomes that are necessary to sustain rural development. Design of a successful rural development strategy involves a combination of technical and institutional change. The ability of rural areas to respond to the opportunities for economic growth generated by local urban

  3. Proposed tokamak poloidal field system development program

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, J.D.; Vogel, H.F.; Warren, R.W.; Weldon, D.M.

    1977-05-01

    A program is proposed to develop poloidal field components for TNS and EPR size tokamak devices and to test these components in realistic circuits. Emphasis is placed upon the development of the most difficult component, the superconducting ohmic-heating coil. Switches must also be developed for testing the coils, and this switching technology is to be extended to meet the requirements for the large scale tokamaks. Test facilities are discussed; power supplies, including a homopolar to drive the coils, are considered; and poloidal field systems studies are proposed.

  4. Cellular Programming and Reprogramming: Sculpting Cell Fate for the Production of Dopamine Neurons for Cell Therapy

    Directory of Open Access Journals (Sweden)

    Julio C. Aguila

    2012-01-01

    success of clinical applications depends on our ability to steer pluripotent stem cells towards the right neuronal identity. In Parkinson disease, the loss of dopamine neurons is more pronounced in the ventrolateral population that projects to the sensorimotor striatum. Because synapses are highly specific, only neurons with this precise identity will contribute, upon transplantation, to the synaptic reconstruction of the dorsal striatum. Thus, understanding the developmental cell program of the mesostriatal dopamine neurons is critical for the identification of the extrinsic signals and cell-intrinsic factors that instruct and, ultimately, determine cell identity. Here, we review how extrinsic signals and transcription factors act together during development to shape midbrain cell fates. Further, we discuss how these same factors can be applied in vitro to induce, select, and reprogram cells to the mesostriatal dopamine fate.

  5. SIMS analysis: Development and evaluation program summary

    International Nuclear Information System (INIS)

    Groenewold, G.S.; Appelhans, A.D.; Ingram, J.C.; Delmore, J.E.; Dahl, D.A.

    1996-11-01

    This report provides an overview of the ''SIMS Analysis: Development and Evaluation Program'', which was executed at the Idaho National Engineering Laboratory from mid-FY-92 to the end of FY-96. It should be noted that prior to FY-1994 the name of the program was ''In-Situ SIMS Analysis''. This report will not go into exhaustive detail regarding program accomplishments, because this information is contained in annual reports which are referenced herein. In summary, the program resulted in the design and construction of an ion trap secondary ion mass spectrometer (IT-SIMS), which is capable of the rapid analysis of environmental samples for adsorbed surface contaminants. This instrument achieves efficient secondary ion desorption by use of a molecular, massive ReO 4 - primary ion particle. The instrument manages surface charge buildup using a self-discharging principle, which is compatible with the pulsed nature of the ion trap. The instrument can achieve high selectivity and sensitivity using its selective ion storage and MS/MS capability. The instrument was used for detection of tri-n-butyl phosphate, salt cake (tank cake) characterization, and toxic metal speciation studies (specifically mercury). Technology transfer was also an important component of this program. The approach that was taken toward technology transfer was that of component transfer. This resulted in transfer of data acquisition and instrument control software in FY-94, and ongoing efforts to transfer primary ion gun and detector technology to other manufacturers

  6. Senescence and programmed cell death : substance or semantics?

    NARCIS (Netherlands)

    Doorn, van W.G.; Woltering, E.J.

    2004-01-01

    The terms senescence and programmed cell death (PCD) have led to some confusion. Senescence as visibly observed in, for example, leaf yellowing and petal wilting, has often been taken to be synonymous with the programmed death of the constituent cells. PCD also obviously refers to cells, which show

  7. 2011 Annual Progress Report: DOE Hydrogen and Fuel Cells Program (Book)

    Energy Technology Data Exchange (ETDEWEB)

    2011-11-01

    In the past year, the DOE Hydrogen and Fuel Cells Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

  8. Meteorological Development Laboratory Student Career Experience Program

    Science.gov (United States)

    McCalla, C., Sr.

    2007-12-01

    The National Oceanic and Atmospheric Administration's (NOAA) National Weather Service (NWS) provides weather, hydrologic, and climate forecasts and warnings for the protection of life and property and the enhancement of the national economy. The NWS's Meteorological Development Laboratory (MDL) supports this mission by developing meteorological prediction methods. Given this mission, NOAA, NWS, and MDL all have a need to continually recruit talented scientists. One avenue for recruiting such talented scientist is the Student Career Experience Program (SCEP). Through SCEP, MDL offers undergraduate and graduate students majoring in meteorology, computer science, mathematics, oceanography, physics, and statistics the opportunity to alternate full-time paid employment with periods of full-time study. Using SCEP as a recruiting vehicle, MDL has employed students who possess some of the very latest technical skills and knowledge needed to make meaningful contributions to projects within the lab. MDL has recently expanded its use of SCEP and has increased the number of students (sometimes called co- ops) in its program. As a co-op, a student can expect to develop and implement computer based scientific techniques, participate in the development of statistical algorithms, assist in the analysis of meteorological data, and verify forecasts. This presentation will focus on describing recruitment, projects, and the application process related to MDL's SCEP. In addition, this presentation will also briefly explore the career paths of students who successfully completed the program.

  9. IAEA Nuclear Security Human Resource Development Program

    International Nuclear Information System (INIS)

    Braunegger-Guelich, A.

    2009-01-01

    The IAEA is at the forefront of international efforts to strengthen the world's nuclear security framework. The current Nuclear Security Plan for 2006-2009 was approved by the IAEA Board of Governors in September 2005. This Plan has three main points of focus: needs assessment, prevention, detection and response. Its overall objective is to achieve improved worldwide security of nuclear and other radioactive material in use, storage and transport, and of their associated facilities. This will be achieved, in particular, through the provision of guidelines and recommendations, human resource development, nuclear security advisory services and assistance for the implementation of the framework in States, upon request. The presentation provides an overview of the IAEA nuclear security human resource development program that is divided into two parts: training and education. Whereas the training program focuses on filling gaps between the actual performance of personnel working in the area of nuclear security and the required competencies and skills needed to meet the international requirements and recommendations described in UN and IAEA documents relating to nuclear security, the Educational Program in Nuclear Security aims at developing nuclear security experts and specialists, at fostering a nuclear security culture and at establishing in this way sustainable knowledge in this field within a State. The presentation also elaborates on the nuclear security computer based learning component and provides insights into the use of human resource development as a tool in achieving the IAEA's long term goal of improving sustainable nuclear security in States. (author)

  10. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new fundable'' R D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  11. Veterinary surveillance laboratories: developing the training program.

    Science.gov (United States)

    Mitchell, Staci L; McCline, Katasha T; Hanfelt, Margery M

    2010-01-01

    The increased need and demand for onsite, frequent, rapid, and portable food and bottled water testing for indicators of microbiological and chemical agents led to the deployment of 2 laboratory veterinary equipment sets. A Surveillance Food Laboratory Program (SFLP) was developed to allow Veterinary Corps commanders to establish targeted testing programs to enhance food safety and wholesomeness, along with faster responses to food defense, suspected foodborne illness, and food/water risk assessment missions. To support the deployment of the veterinary equipment sets and the SFLP, 2 new functional courses were developed by the Department of Veterinary Science. The Surveillance Food Laboratory Technician Course teaches essential technical skills that include sample processing, assay methodologies, results review, and interpretation of results produced by these laboratories. The Surveillance Food Laboratory Manager Course, developed for designated managers of the laboratories and laboratory programs, teaches the skills critical to ensuring proper surveillance laboratory oversight, testing, evaluation of results, risk communication, and response to presumptive positive results produced by the laboratories. Together, the courses allowed for the successful deployment of the unique veterinary equipment sets, resulting in development of fully operational surveillance laboratories in support of food protection missions in every major theater of operations.

  12. Solid Oxide Fuel Cell (SOFC) Development in Denmark

    DEFF Research Database (Denmark)

    Linderoth, Søren; Larsen, Peter Halvor; Mogensen, Mogens Bjerg

    2007-01-01

    on larger anode-supported cells as well as a new generation of SOFCs based on porous metal supports and new electrode and electrolyte materials. The SOFC program comprises development of next generation of cells and multi stack modules for operation at lower temperature with increased durability...

  13. Clean Technology Evaluation & Workforce Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Patricia Glaza

    2012-12-01

    The overall objective of the Clean Technology Evaluation portion of the award was to design a process to speed up the identification of new clean energy technologies and match organizations to testing and early adoption partners. The project was successful in identifying new technologies targeted to utilities and utility technology integrators, in developing a process to review and rank the new technologies, and in facilitating new partnerships for technology testing and adoption. The purpose of the Workforce Development portion of the award was to create an education outreach program for middle & high-school students focused on clean technology science and engineering. While originally targeting San Diego, California and Cambridge, Massachusetts, the scope of the program was expanded to include a major clean technology speaking series and expo as part of the USA Science & Engineering Festival on the National Mall in Washington, D.C.

  14. Sensor Development for PEM Fuel Cell Systems

    Energy Technology Data Exchange (ETDEWEB)

    Steve Magee; Richard Gehman

    2005-07-12

    This document reports on the work done by Honeywell Sensing and Control to investigate the feasibility of modifying low cost Commercial Sensors for use inside a PEM Fuel Cell environment. Both stationary and automotive systems were considered. The target environment is hotter (100 C) than the typical commercial sensor maximum of 70 C. It is also far more humid (100% RH condensing) than the more typical 95% RH non-condensing at 40 C (4% RH maximum at 100 C). The work focused on four types of sensors, Temperature, Pressure, Air Flow and Relative Humidity. Initial design goals were established using a market research technique called Market Driven Product Definition (MDPD). A series of interviews were conducted with various users and system designers in their facilities. The interviewing team was trained in data taking and analysis per the MDPD process. The final result was a prioritized and weighted list of both requirements and desires for each sensor. Work proceeded on concept development for the 4 types of sensors. At the same time, users were developing the actual fuel cell systems and gaining knowledge and experience in the use of sensors and controls systems. This resulted in changes to requirements and desires that were not anticipated during the MDPD process. The concepts developed met all the predicted requirements. At the completion of concept development for the Pressure Sensor, it was determined that the Fuel Cell developers were happy with off-the-shelf automotive pressure sensors. Thus, there was no incentive to bring a new Fuel Cell Specific Pressure Sensor into production. Work was therefore suspended. After the experience with the Pressure Sensor, the requirements for a Temperature Sensor were reviewed and a similar situation applied. Commercially available temperature sensors were adequate and cost effective and so the program was not continued from the Concept into the Design Phase.

  15. Fuel cell development for transportation: Catalyst development

    Energy Technology Data Exchange (ETDEWEB)

    Doddapaneni, N. [Sandia National Lab., Albuquerque, NM (United States)

    1996-04-01

    Fuel cells are being considered as alternate power sources for transportation and stationary applications. With proton exchange membrane (PEM) fuel cells the fuel crossover to cathodes causes severe thermal management and cell voltage drop due to oxidation of fuel at the platinized cathodes. The main goal of this project was to design, synthesize, and evaluate stable and inexpensive transition metal macrocyclic catalysts for the reduction of oxygen and be electrochemically inert towards anode fuels such as hydrogen and methanol.

  16. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    CIEE's second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director's discretionary research, and exploratory research will also be featured in this report.

  17. Energy management, planning, and program development

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-01-01

    The Ohio ERDA is statutorily required to maintain an energy-planning capability and to manage a programmatic effort to bring Ohio energy supply and demand into balance consistent with the state's growth and development needs. The Ohio Energy Information System is the major planning tool and it encompasses the Ohio Energy Data Base, the Energy Short-Term Emergency Evalution Model, and a capability to assess alternative-policy-action impacts. A discussion of the program is presented. (MCW)

  18. Borehole Plugging-Materials Development Program

    International Nuclear Information System (INIS)

    Gulick, C.W. Jr.

    1978-06-01

    This report discusses the background and first year's results of the grouting materials development program for plugging boreholes associated with the Nuclear Waste Isolation Pilot Plant. The grouts are to be pumpable, impermeable, and durable for many thousands of years. The work was done at the Concrete Laboratory of the U.S. Army Engineer Waterways Experiment Station (WES), Vicksburg, Mississippi. The workability, strength, porosity, bonding, expansion, and permeability data are summarized and discussed. The work is continuing at WES

  19. Game Programming Course - Creative Design and Development

    Directory of Open Access Journals (Sweden)

    Jaak Henno

    2008-10-01

    Full Text Available Rapid developments of the Electronic Entertainment - computer and video games, virtual environments, the "Games 3.0" revolution - influences also courses about Games and Virtual Environments. In the following is discussed the course “Games and Virtual Environments” presented in the fall 2007 term in Tallinn University of Technology; the main emphasis of the course was not on programming technology, but on understanding games as a special form of communication and exploring specific features of this form.

  20. Instructor development program at Three Mile Island

    International Nuclear Information System (INIS)

    Irizarry, C.A.; Jones, J.W.; Knief, R.

    1981-01-01

    The Three Mile Island (TMI) Training Department has prepared and conducted Instructor Development Programs which have upgraded the capabilities of its instructors and provided more uniformity among its diverse efforts. The week-long course was prepared in-house by a staff that combined college teaching experience in both education and technical subjects with strong background in industrial training. Through the first two offerings of the course, twenty-five individuals have participated and eight have served on the course staff

  1. Apoptotic-like programmed cell death in plants.

    Science.gov (United States)

    Reape, Theresa J; McCabe, Paul F

    2008-01-01

    Programmed cell death (PCD) is now accepted as a fundamental cellular process in plants. It is involved in defence, development and response to stress, and our understanding of these processes would be greatly improved through a greater knowledge of the regulation of plant PCD. However, there may be several types of PCD that operate in plants, and PCD research findings can be confusing if they are not assigned to a specific type of PCD. The various cell-death mechanisms need therefore to be carefully described and defined. This review describes one of these plant cell death processes, namely the apoptotic-like PCD (AL-PCD). We begin by examining the hallmark 'apoptotic-like' features (protoplast condensation, DNA degradation) of the cell's destruction that are characteristic of AL-PCD, and include examples of AL-PCD during the plant life cycle. The review explores the possible cellular 'executioners' (caspase-like molecules; mitochondria; de novo protein synthesis) that are responsible for the hallmark features of the cellular destruction. Finally, senescence is used as a case study to show that a rigorous definition of cell-death processes in plant cells can help to resolve arguments that occur in the scientific literature regarding the timing and control of plant cell death.

  2. Hypoxia: From Placental Development to Fetal Programming.

    Science.gov (United States)

    Fajersztajn, Lais; Veras, Mariana Matera

    2017-10-16

    Hypoxia may influence normal and different pathological processes. Low oxygenation activates a variety of responses, many of them regulated by hypoxia-inducible factor 1 complex, which is mostly involved in cellular control of O 2 consumption and delivery, inhibition of growth and development, and promotion of anaerobic metabolism. Hypoxia plays a significant physiological role in fetal development; it is involved in different embryonic processes, for example, placentation, angiogenesis, and hematopoiesis. More recently, fetal hypoxia has been associated directly or indirectly with fetal programming of heart, brain, and kidney function and metabolism in adulthood. In this review, the role of hypoxia in fetal development, placentation, and fetal programming is summarized. Hypoxia is a basic mechanism involved in different pregnancy disorders and fetal health developmental complications. Although there are scientific data showing that hypoxia mediates changes in the growth trajectory of the fetus, modulates gene expression by epigenetic mechanisms, and determines the health status later in adulthood, more mechanistic studies are needed. Furthermore, if we consider that intrauterine hypoxia is not a rare event, and can be a consequence of unavoidable exposures to air pollution, nutritional deficiencies, obesity, and other very common conditions (drug addiction and stress), the health of future generations may be damaged and the incidence of some diseases will markedly increase as a consequence of disturbed fetal programming. Birth Defects Research 109:1377-1385, 2017.© 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  3. Designing a leadership development program for surgeons.

    Science.gov (United States)

    Jaffe, Gregory A; Pradarelli, Jason C; Lemak, Christy Harris; Mulholland, Michael W; Dimick, Justin B

    2016-01-01

    Although numerous leadership development programs (LDPs) exist in health care, no programs have been specifically designed to meet the needs of surgeons. This study aimed to elicit practicing surgeons' motivations and desired goals for leadership training to design an evidence-based LDP in surgery. At a large academic health center, we conducted semistructured interviews with 24 surgical faculty members who voluntarily applied and were selected for participation in a newly created LDP. Transcriptions of the interviews were analyzed using analyst triangulation and thematic coding to extract major themes regarding surgeons' motivations and perceived needs for leadership knowledge and skills. Themes from interview responses were then used to design the program curriculum specifically to meet the leadership needs of surgical faculty. Three major themes emerged regarding surgeons' motivations for seeking leadership training: (1) Recognizing key gaps in their formal preparation for leadership roles; (2) Exhibiting an appetite for personal self-improvement; and (3) Seeking leadership guidance for career advancement. Participants' interviews revealed four specific domains of knowledge and skills that they indicated as desired takeaways from a LDP: (1) leadership and communication; (2) team building; (3) business acumen/finance; and (4) greater understanding of the health care context. Interviews with surgical faculty members identified gaps in prior leadership training and demonstrated concrete motivations and specific goals for participating in a formal leadership program. A LDP that is specifically tailored to address the needs of surgical faculty may benefit surgeons at a personal and institutional level. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Professional development for nuclear power programs in developing countries

    International Nuclear Information System (INIS)

    Kanter, M.A.

    1983-01-01

    Countries entering nuclear power programs for the first time find that inadequate planning for the development of trained manpower is a critical factor in the success of their programs. This requires the early training of a team for the planning and acquisition effort to be followed by training for the supervision of construction. In addition, there is the more readily recognized training for operation. Typical manpower needs for such projects have been documented by the International Atomic Energy Agency. The basic academic training of engineers and scientists, which should be available within the country; advanced academic training, which is often secured in institutions abroad; specialized training abroad by international agencies; specialized training by the vendors of nuclear equipment; and the development of indigenous training. This paper outlines all of these avenues but will concentrate on the training available through international agencies and on the development of indigenous training capability

  5. Developing Signal-Pattern-Recognition Programs

    Science.gov (United States)

    Shelton, Robert O.; Hammen, David

    2006-01-01

    Pattern Interpretation and Recognition Application Toolkit Environment (PIRATE) is a block-oriented software system that aids the development of application programs that analyze signals in real time in order to recognize signal patterns that are indicative of conditions or events of interest. PIRATE was originally intended for use in writing application programs to recognize patterns in space-shuttle telemetry signals received at Johnson Space Center's Mission Control Center: application programs were sought to (1) monitor electric currents on shuttle ac power busses to recognize activations of specific power-consuming devices, (2) monitor various pressures and infer the states of affected systems by applying a Kalman filter to the pressure signals, (3) determine fuel-leak rates from sensor data, (4) detect faults in gyroscopes through analysis of system measurements in the frequency domain, and (5) determine drift rates in inertial measurement units by regressing measurements against time. PIRATE can also be used to develop signal-pattern-recognition software for different purposes -- for example, to monitor and control manufacturing processes.

  6. Development of an effective valve packing program

    Energy Technology Data Exchange (ETDEWEB)

    Hart, K.A.

    1996-12-01

    Current data now shows that graphite valve packing installed within the guidance of a controlled program produces not only reliable stem sealing but predictable running loads. By utilizing recent technological developments in valve performance monitoring for both MOV`s and AOV`s, valve packing performance can be enhanced while reducing maintenance costs. Once known, values are established for acceptable valve packing loads, the measurement of actual valve running loads via the current MOV/AOV diagnostic techniques can provide indication of future valve stem sealing problems, improper valve packing installation or identify the opportunity for valve packing program improvements. At times the full benefit of these advances in material and predictive technology remain under utilized due to simple past misconceptions associated with valve packing. This paper will explore the basis for these misconceptions, provide general insight into the current understanding of valve packing and demonstrate how with this new understanding and current valve diagnostic equipment the key aspects required to develop an effective, quality valve packing program fit together. The cost and operational benefits provided by this approach can be significant impact by the: elimination of periodic valve repacking, reduction of maintenance costs, benefits of leak-free valve operation, justification for reduced Post Maintenance Test Requirements, reduced radiation exposure, improved plant appearance.

  7. Development of an effective valve packing program

    International Nuclear Information System (INIS)

    Hart, K.A.

    1996-01-01

    Current data now shows that graphite valve packing installed within the guidance of a controlled program produces not only reliable stem sealing but predictable running loads. By utilizing recent technological developments in valve performance monitoring for both MOV's and AOV's, valve packing performance can be enhanced while reducing maintenance costs. Once known, values are established for acceptable valve packing loads, the measurement of actual valve running loads via the current MOV/AOV diagnostic techniques can provide indication of future valve stem sealing problems, improper valve packing installation or identify the opportunity for valve packing program improvements. At times the full benefit of these advances in material and predictive technology remain under utilized due to simple past misconceptions associated with valve packing. This paper will explore the basis for these misconceptions, provide general insight into the current understanding of valve packing and demonstrate how with this new understanding and current valve diagnostic equipment the key aspects required to develop an effective, quality valve packing program fit together. The cost and operational benefits provided by this approach can be significant impact by the: elimination of periodic valve repacking, reduction of maintenance costs, benefits of leak-free valve operation, justification for reduced Post Maintenance Test Requirements, reduced radiation exposure, improved plant appearance

  8. CELLFS: TAKING THE "DMA" OUT OF CELL PROGRAMMING

    Energy Technology Data Exchange (ETDEWEB)

    IONKOV, LATCHESAR A. [Los Alamos National Laboratory; MIRTCHOVSKI, ANDREY A. [Los Alamos National Laboratory; NYRHINEN, AKI M. [Los Alamos National Laboratory

    2007-01-09

    In this paper we present a new programming model for the Cell BE architecture of scalar multiprocessors. They call this programming model CellFS. CellFS aims at simplifying the task of managing I/O between the local store of the processing units and main memory. The CellFS support library provides the means for transferring data via simple file I/O operations between the PPU and the SPU.

  9. Lightweight composite fighting cover prototype development program

    Energy Technology Data Exchange (ETDEWEB)

    Wrenn, G.E. Jr.; Frame, B.J.; Gwaltney, R.C.; Akerman, M.A.

    1996-07-01

    The U.S. Army Field Assistance Science and Technology Program requested Oak Ridge National Laboratory (ORNL) to demonstrate the use of lightweight composite materials in construction of overhead covers for reinforced infantry fighting positions. In recent years, ORNL researchers have designed and tested several concepts for lightweight ballistic protection structures, and they have developed numerous prototype composite structures for military and civilian applications. In the current program, composite panel designs and materials are tested and optimized to meet anticipated static and dynamic load conditions for the overhead cover structure. Ten prototype composite covers were built at ORNL for use in Army field tests. Each composite cover has a nominal surface area of 12 ft[sup 2] and a nominal weight of 8 lb. Four of the prototypes are made with folding sections to improve their handling characteristics. The composite covers exhibit equivalent performance in Army field tests to covers made with conventional materials that weigh four times as much.

  10. Research and development program, fiscal year 1970

    Energy Technology Data Exchange (ETDEWEB)

    1968-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1970 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine Program may be summarized as follows: (1) investigation of the effects of ionizing radiation on systems of biological significance and on living organisms; (2) assessment and study of the immediate and long term consequences of the environmental radioactivity on flora, fauna, and man; (3) development of beneficial uses of ionizing radiation and radioactive substances in medicine and biology; and (4) the conduct of training and educational activities in fields related to the biological and medical aspects of radiation.

  11. Plant programmed cell death, ethylene and flower senescence

    NARCIS (Netherlands)

    Woltering, E.J.; Jong, de A.; Hoeberichts, F.A.; Iakimova, E.T.; Kapchina, V.

    2005-01-01

    Programmed cell death (PCD) applies to cell death that is part of the normal life of multicellular organisms. PCD is found throughout the animal and plant kingdoms; it is an active process in which a cell suicide pathway is activated resulting in controlled disassembly of the cell. Most cases of PCD

  12. Tissue Force Programs Cell Fate and Tumor Aggression.

    Science.gov (United States)

    Northey, Jason J; Przybyla, Laralynne; Weaver, Valerie M

    2017-11-01

    Biomechanical and biochemical cues within a tissue collaborate across length scales to direct cell fate during development and are critical for the maintenance of tissue homeostasis. Loss of tensional homeostasis in a tissue not only accompanies malignancy but may also contribute to oncogenic transformation. High mechanical stress in solid tumors can impede drug delivery and may additionally drive tumor progression and promote metastasis. Mechanistically, biomechanical forces can drive tumor aggression by inducing a mesenchymal-like switch in transformed cells so that they attain tumor-initiating or stem-like cell properties. Given that cancer stem cells have been linked to metastasis and treatment resistance, this raises the intriguing possibility that the elevated tissue mechanics in tumors could promote their aggression by programming their phenotype toward that exhibited by a stem-like cell. Significance: Recent findings argue that mechanical stress and elevated mechanosignaling foster malignant transformation and metastasis. Prolonged corruption of tissue tension may drive tumor aggression by altering cell fate specification. Thus, strategies that could reduce tumor mechanics might comprise effective approaches to prevent the emergence of treatment-resilient metastatic cancers. Cancer Discov; 7(11); 1224-37. ©2017 AACR. ©2017 American Association for Cancer Research.

  13. SNAP-8 electrical generating system development program

    Science.gov (United States)

    1971-01-01

    The SNAP-8 program has developed the technology base for one class of multikilowatt dynamic space power systems. Electrical power is generated by a turbine-alternator in a mercury Rankine-cycle loop to which heat is transferred and removed by means of sodium-potassium eutectic alloy subsystems. Final system overall criteria include a five-year operating life, restartability, man rating, and deliverable power in the 90 kWe range. The basic technology has been demonstrated by more than 400,000 hours of major component endurance testing and numerous startup and shutdown cycles. A test system, comprised of developed components, delivered up to 35 kWe for a period exceeding 12,000 hours. The SNAP-8 system baseline is considered to have achieved a level of technology suitable for final application development for long-term multikilowatt space missions.

  14. Mixed Waste Integrated Program emerging technology development

    Energy Technology Data Exchange (ETDEWEB)

    Berry, J.B. [Oak Ridge National Lab., TN (United States); Hart, P.W. [USDOE, Washington, DC (United States)

    1994-06-01

    The US Department of Energy (DOE) is responsible for the management and treatment of its mixed low-level wastes (MLLW). MLLW are regulated under both the Resource Conservation and Recovery Act and various DOE orders. Over the next 5 years, DOE will manage over 1.2 m{sup 3} of MLLW and mixed transuranic (MTRU) wastes. In order to successfully manage and treat these mixed wastes, DOE must adapt and develop characterization, treatment, and disposal technologies which will meet performance criteria, regulatory approvals, and public acceptance. Although technology to treat MLLW is not currently available without modification, DOE is committed to developing such treatment technologies and demonstrating them at the field scale by FY 1997. The Office of Research and Development`s Mixed Waste Integrated Program (MWIP) within the DOE Office of Environmental Management (EM), OfFice of Technology Development, is responsible for the development and demonstration of such technologies for MLLW and MTRU wastes. MWIP advocates and sponsors expedited technology development and demonstrations for the treatment of MLLW.

  15. Asymmetric cell division during T cell development controls downstream fate

    Science.gov (United States)

    Pham, Kim; Shimoni, Raz; Charnley, Mirren; Ludford-Menting, Mandy J.; Hawkins, Edwin D.; Ramsbottom, Kelly; Oliaro, Jane; Izon, David; Ting, Stephen B.; Reynolds, Joseph; Lythe, Grant; Molina-Paris, Carmen; Melichar, Heather; Robey, Ellen; Humbert, Patrick O.; Gu, Min

    2015-01-01

    During mammalian T cell development, the requirement for expansion of many individual T cell clones, rather than merely expansion of the entire T cell population, suggests a possible role for asymmetric cell division (ACD). We show that ACD of developing T cells controls cell fate through differential inheritance of cell fate determinants Numb and α-Adaptin. ACD occurs specifically during the β-selection stage of T cell development, and subsequent divisions are predominantly symmetric. ACD is controlled by interaction with stromal cells and chemokine receptor signaling and uses a conserved network of polarity regulators. The disruption of polarity by deletion of the polarity regulator, Scribble, or the altered inheritance of fate determinants impacts subsequent fate decisions to influence the numbers of DN4 cells arising after the β-selection checkpoint. These findings indicate that ACD enables the thymic microenvironment to orchestrate fate decisions related to differentiation and self-renewal. PMID:26370500

  16. Research and development program, fiscal year 1966

    Energy Technology Data Exchange (ETDEWEB)

    1964-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1966 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Chemical Toxicity; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine program may be summarized as follows: (1) investigation of the effects of ionizing radiation on living organisms and systems of biological significance; (2) investigation of the dynamic aspects of physiological and biochemical processes in man, animals and plants and how these processes are modified by radiation and related pathological states; (3) the assessment and study of the immediate and long term consequences of the operation or detonation of nuclear devices on the fauna, and flora in man's environment and on man; (4) the development of methods of minimizing or preventing the detrimental effects of ionizing radiation; (5) research in, and development of, beneficial uses of ionizing radiation and radioactive substances in medicine and biology; (6) research in the development of new and more efficient radiation detection devices; (7) research, including field studies, as mutually agreed upon by the Commission and the University, in connection with the conduct of weapon tests and biomedical and civil effects experiments at such tests conducted at continental and overseas test sites; and (8) the conduct of training and educational activities in the biological and medical aspects of radiation and related fields.

  17. French development program on fuel cycle

    International Nuclear Information System (INIS)

    Viala, M.; Bourgeois, M.

    1991-01-01

    The need to close the fuel cycle of fast reactors makes the development of the cycle installations (fuel fabrication, irradiated assembly conditioning before reprocessing, reprocessing and waste management) especially independent with the development of the reactor. French experience with the integrated cycle over a period of about 25 years, the tonnage of fuels fabricated (more than 100 t of mixed oxides) for the Rapsodie, Phoenix and SuperPhoenix reactors, and the tonnage of reprocessed fuel (nearly 30 t of plutonium fuel) demonstrate the control of the cycle operations. The capacities of the cycle installations in existence and under construction are largely adequate for presents needs, even including a new European EFR reactor. They include the Cadarache fuel fabrication complex, the La Hague UP2-800 reprocessing plant, and the Marcoule pilot facility. Short- and medium-term R and D programs are connected with fuel developments, with the primary objective of very high burnups. For the longer term and for a specific plant to reprocess fast reactor fuels, the programs could concern new fabrication and reprocessing systems and the study of the consequences of the reduction in fuel out-of-core time

  18. Towards programming languages for genetic engineering of living cells.

    Science.gov (United States)

    Pedersen, Michael; Phillips, Andrew

    2009-08-06

    Synthetic biology aims at producing novel biological systems to carry out some desired and well-defined functions. An ultimate dream is to design these systems at a high level of abstraction using engineering-based tools and programming languages, press a button, and have the design translated to DNA sequences that can be synthesized and put to work in living cells. We introduce such a programming language, which allows logical interactions between potentially undetermined proteins and genes to be expressed in a modular manner. Programs can be translated by a compiler into sequences of standard biological parts, a process that relies on logic programming and prototype databases that contain known biological parts and protein interactions. Programs can also be translated to reactions, allowing simulations to be carried out. While current limitations on available data prevent full use of the language in practical applications, the language can be used to develop formal models of synthetic systems, which are otherwise often presented by informal notations. The language can also serve as a concrete proposal on which future language designs can be discussed, and can help to guide the emerging standard of biological parts which so far has focused on biological, rather than logical, properties of parts.

  19. Duplex tube steam reformer development program

    Energy Technology Data Exchange (ETDEWEB)

    Lewe, C K; Nieto, J M; Papadopoulos, A

    1978-09-01

    Work done in partial fulfillment of Task 7 of the Duplex Steam Reformer Development Program is described. The DSR concept acts as a double barrier between a process heat high temperature reactor plant (PNP) and a closed loop chemical heat pipe (CHP) for the long distance transport of chemical energy to a remote industrial user. The current state of the DSR design is described as well as related systems and equipment. The PNP concept presented is based upon work currently underway in the Federal Republic of Germany.

  20. Duplex tube steam reformer development program

    International Nuclear Information System (INIS)

    Lewe, C.K.; Nieto, J.M.; Papadopoulos, A.

    1978-09-01

    Work done in partial fulfillment of Task 7 of the Duplex Steam Reformer Development Program is described. The DSR concept acts as a double barrier between a process heat high temperature reactor plant (PNP) and a closed loop chemical heat pipe (CHP) for the long distance transport of chemical energy to a remote industrial user. The current state of the DSR design is described as well as related systems and equipment. The PNP concept presented is based upon work currently underway in the Federal Republic of Germany

  1. Program Developments: Formal Explanations of Implementations.

    Science.gov (United States)

    1982-08-01

    Developments: Formal Explanations of Implementations ’V 0 CD 0 -n rat INORAIO S.EN >.IN-iIUT : 0 C)- - LA - INFORMATION SCIENCES. INSTITUTE 4616 Admiralti’ Cr...We could write the steps which transform . .. I I la 25 ... the program in-line, or we could invoke a transformation which is globally defined. Let’s...34 Acta Informatica 10, (3), 1978, 245-264,265-272. [Balzer 69] Balzer, R. M., "EXDAMS--extendable debugging and monitoring system," in Spring Joint

  2. Standard Review Plan Update and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    This implementing procedures document (IPD) was prepared for use in implementing tasks under the standard review plan update and development program (SRP-UDP). The IPD provides comprehensive guidance and detailed procedures for SRP-UDP tasks. The IPD is mandatory for contractors performing work for the SRP-UDP. It is guidance for the staff. At the completion of the SRP-UDP, the IPD will be revised (to remove the UDP aspects) and will replace NRR Office Letter No. 800 as long-term maintenance procedures.

  3. Standard Review Plan Update and Development Program

    International Nuclear Information System (INIS)

    1992-05-01

    This implementing procedures document (IPD) was prepared for use in implementing tasks under the standard review plan update and development program (SRP-UDP). The IPD provides comprehensive guidance and detailed procedures for SRP-UDP tasks. The IPD is mandatory for contractors performing work for the SRP-UDP. It is guidance for the staff. At the completion of the SRP-UDP, the IPD will be revised (to remove the UDP aspects) and will replace NRR Office Letter No. 800 as long-term maintenance procedures

  4. Programming language concepts for software developers

    DEFF Research Database (Denmark)

    Sestoft, Peter

    2008-01-01

    This note describes and motivates our current plans for an undergraduate course on programming language concepts for software development students. We describe the competences we expect students to acquire as well as the topics covered by the course. We plan to use C# and Scheme as instruction...... languages, and will study the implementation of Java and C# with their underlying platforms, the Java Virtual Machine and .NET Common Language Runtime. We emphasize implementation exercises and experiments. This comes at the expense of classical compiler course subjects such as register allocation...

  5. Tested program for Third World economic development

    Energy Technology Data Exchange (ETDEWEB)

    Lindholm, R.W.

    1977-04-01

    Some of the responsibility for the inability of Western-oriented Third World Countries (1) to make democratic economic institutions work rests upon advisers to American and international financial institutions who recommend principles of economic growth distilled out of Keynesian recipes for an over-saving Western society of the 1930s, and out of aspects of American experience with no applicability elsewhere. Applicable aspects of U.S. experience suggest a program relying on capitalistic drives and using fiscal and monetary policy of the type that proved useful in the development of democratic capitalism in the U.S. in the 19th century.

  6. The Australian Hydrogen and Fuel Cells Education Program

    International Nuclear Information System (INIS)

    Luigi Bonadio

    2006-01-01

    The next generation of engineers and scientists will face great technical, economic and political challenges to satisfy increasing demands for a secure, reliable and affordable global energy system that maintains and enhances current standards of living. The Australian Hydrogen and Fuel Cells Education Program aims to bolster the quality and relevance of primary and secondary school teaching in emerging areas of science, technology and environmental/sustainability studies using hydrogen, in its capacity as a versatile energy carrier, as the educational basis for teacher and student learning. Critical advances in specific areas of hydrogen production, distribution, storage and end-use technologies arise when students are engaged to develop and apply a broad range of disciplinary and interdisciplinary knowledge and practical skills. A comprehensive hydrogen and fuel cell technology teaching module will be developed to complement existing fuels and energy curricula across Australian schools. The pilot program will be delivered via the collaboration of nine trial schools, a broad range of technical and pedagogy experts and representatives of professional bodies and industry. The program features essential and extensive teacher consultation, a professional learning and development course, industry site visits and a dedicated research and evaluation study. This initiative aims to bolster teacher literacy and student participation in the design, construction and operation of various hydrogen and fuel cell devices and extended activities. Students will reflect on and formally present their learning experiences via several dedicated fora including an awards ceremony where outstanding performance of leading schools, teachers and student groups within the cluster will be acknowledged. (authors)

  7. The Australian Hydrogen and Fuel Cells Education Program

    Energy Technology Data Exchange (ETDEWEB)

    Luigi Bonadio [Senior Consultant Luigi Bonadio and Associates (Australia)

    2006-07-01

    The next generation of engineers and scientists will face great technical, economic and political challenges to satisfy increasing demands for a secure, reliable and affordable global energy system that maintains and enhances current standards of living. The Australian Hydrogen and Fuel Cells Education Program aims to bolster the quality and relevance of primary and secondary school teaching in emerging areas of science, technology and environmental/sustainability studies using hydrogen, in its capacity as a versatile energy carrier, as the educational basis for teacher and student learning. Critical advances in specific areas of hydrogen production, distribution, storage and end-use technologies arise when students are engaged to develop and apply a broad range of disciplinary and interdisciplinary knowledge and practical skills. A comprehensive hydrogen and fuel cell technology teaching module will be developed to complement existing fuels and energy curricula across Australian schools. The pilot program will be delivered via the collaboration of nine trial schools, a broad range of technical and pedagogy experts and representatives of professional bodies and industry. The program features essential and extensive teacher consultation, a professional learning and development course, industry site visits and a dedicated research and evaluation study. This initiative aims to bolster teacher literacy and student participation in the design, construction and operation of various hydrogen and fuel cell devices and extended activities. Students will reflect on and formally present their learning experiences via several dedicated fora including an awards ceremony where outstanding performance of leading schools, teachers and student groups within the cluster will be acknowledged. (authors)

  8. Program Assistant | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Under the direction of the Program Leader, the Program Assistant provides operational and administrative assistance to the Program Leader and Program Staff, performs a variety of administrative, coordination and logistical services in support of the operations of the Program, and assists with information management the ...

  9. Cosmic Origins (COR) Technology Development Program Overview

    Science.gov (United States)

    Werneth, Russell; Pham, B.; Clampin, M.

    2014-01-01

    The Cosmic Origins (COR) Program Office was established in FY11 and resides at the NASA Goddard Space Flight Center (GSFC). The office serves as the implementation arm for the Astrophysics Division at NASA Headquarters for COR Program related matters. We present an overview of the Program’s technology management activities and the Program’s technology development portfolio. We discuss the process for addressing community-provided technology needs and the Technology Management Board (TMB)-vetted prioritization and investment recommendations. This process improves the transparency and relevance of technology investments, provides the community a voice in the process, and leverages the technology investments of external organizations by defining a need and a customer. Goals for the COR Program envisioned by the National Research Council’s (NRC) “New Worlds, New Horizons in Astronomy and Astrophysics” (NWNH) Decadal Survey report includes a 4m-class UV/optical telescope that would conduct imaging and spectroscopy as a post-Hubble observatory with significantly improved sensitivity and capability, a near-term investigation of NASA participation in the Japanese Aerospace Exploration Agency/Institute of Space and Astronautical Science (JAXA/ISAS) Space Infrared Telescope for Cosmology and Astrophysics (SPICA) mission, and future Explorers.

  10. Mixed Waste Integrated Program emerging technology development

    International Nuclear Information System (INIS)

    Berry, J.B.; Hart, P.W.

    1994-01-01

    The US Department of Energy (DOE) is responsible for the management and treatment of its mixed low-level wastes (MLLW). MLLW are regulated under both the Resource Conservation and Recovery Act and various DOE orders. Over the next 5 years, DOE will manage over 1.2 m 3 of MLLW and mixed transuranic (MTRU) wastes. In order to successfully manage and treat these mixed wastes, DOE must adapt and develop characterization, treatment, and disposal technologies which will meet performance criteria, regulatory approvals, and public acceptance. Although technology to treat MLLW is not currently available without modification, DOE is committed to developing such treatment technologies and demonstrating them at the field scale by FY 1997. The Office of Research and Development's Mixed Waste Integrated Program (MWIP) within the DOE Office of Environmental Management (EM), OfFice of Technology Development, is responsible for the development and demonstration of such technologies for MLLW and MTRU wastes. MWIP advocates and sponsors expedited technology development and demonstrations for the treatment of MLLW

  11. High fat programming of beta cell compensation, exhaustion, death and dysfunction.

    Science.gov (United States)

    Cerf, Marlon E

    2015-03-01

    Programming refers to events during critical developmental windows that shape progeny health outcomes. Fetal programming refers to the effects of intrauterine (in utero) events. Lactational programming refers to the effects of events during suckling (weaning). Developmental programming refers to the effects of events during both fetal and lactational life. Postnatal programming refers to the effects of events either from birth (lactational life) to adolescence or from weaning (end of lactation) to adolescence. Islets are most plastic during the early life course; hence programming during fetal and lactational life is most potent. High fat (HF) programming is the maintenance on a HF diet (HFD) during critical developmental life stages that alters progeny metabolism and physiology. HF programming induces variable diabetogenic phenotypes dependent on the timing and duration of the dietary insult. Maternal obesity reinforces HF programming effects in progeny. HF programming, through acute hyperglycemia, initiates beta cell compensation. However, HF programming eventually leads to chronic hyperglycemia that triggers beta cell exhaustion, death and dysfunction. In HF programming, beta cell dysfunction often co-presents with insulin resistance. Balanced, healthy nutrition during developmental windows is critical for preserving beta cell structure and function. Thus early positive nutritional interventions that coincide with the development of beta cells may reduce the overwhelming burden of diabetes and metabolic disease. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Louisiana's oil spill program : new developments

    International Nuclear Information System (INIS)

    Debusschere, K.; Tedford, R.; Brolin, J.; Lorentz, W.

    2000-01-01

    The Louisiana Oil Spill Coordinator's Office (LOSCO) was established to improve oil spill response, spill prevention and coordination. Louisiana is challenged with having the highest exposure of oil spills because a large portion of its economy is based on oil and gas exploration and production. LOSCO will find ways to minimize the risk of unauthorized oil spills and will address damage assessment and restoration efforts. The aging oil and gas infrastructure in Louisiana has also been recognized as a potential major source for oil spills. LOSCO locates potential spill locations and assesses the risks associated with the sites, some of which are 100 years old. LOSCO also initiated the following two programs: (1) the Abandoned Barge Program initiated in 1993 to remove abandoned barges that pose a high risk for oil discharge, and (2) the Abandoned Non-Hazardous Oil Waste (NOW) Pit and Facility Program initiated in 1992 to locate and remove structures, pits and wells that pose a risk for oil spills. About 25,000 facilities, pits, sumps and reservoirs have been inventoried and evaluated to determine if they pose a risk to human health or the environment. The Louisiana Oil Spill Prevention and Response Act (OSPRA) of 1991 allocates up to $2 million per year for the abatement of oil spills from abandoned facilities in Louisiana. The state legislature has also created the Applied and Educational Oil Spill Research and Development Program (OSRADP) to fund oil spill research. Since 1993, OSRADP has granted 68 awards in support of 42 projects, many of which focused on recovery and cleanup methods including in-situ burning, fate and effect of oil in Louisiana environments, bioremediation, phytoremediation, composting, chemical cleaners, dispersants, sorbents, and solidifiers. 3 refs., 1 tab

  13. LIQUID HYDROCARBON FUEL CELL DEVELOPMENT.

    Science.gov (United States)

    A compound anode consists of a reforming catalyst bed in direct contact with a palladium-silver fuel cell anode. The objective of this study was to...prove the feasibility of operating a compound anode fuel cell on a liquid hydrocarbon and to define the important parameters that influence cell...performance. Both reformer and fuel cell tests were conducted with various liquid hydrocarbon fuels. Included in this report is a description of the

  14. Program Officer | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Job Summary Working as a member of one or two multi-disciplinary teams and under the guidance of a senior team member, Program Leader (PL) and/or Program Manager (PM) if applicable, the Program Officer (PO):

  15. 2016 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-03-09

    The 2016 Annual Progress Report summarizes fiscal year 2016 activities and accomplishments by projects funded by the DOE Hydrogen and Fuel Cells Program. It covers the program areas of hydrogen production; hydrogen delivery; hydrogen storage; fuel cells; manufacturing R&D; technology validation; safety, codes and standards; systems analysis; market transformation; and Small Business Innovation Research projects.

  16. 2015 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-12-23

    The 2015 Annual Progress Report summarizes fiscal year 2015 activities and accomplishments by projects funded by the DOE Hydrogen and Fuel Cells Program. It covers the program areas of hydrogen production; hydrogen delivery; hydrogen storage; fuel cells; manufacturing R&D; technology validation; safety, codes and standards; systems analysis; and market transformation.

  17. Hydrogen peroxide as a signal controlling plant programmed cell death

    NARCIS (Netherlands)

    Gechev, Tsanko S.; Hille, Jacques

    2005-01-01

    Hydrogen peroxide (H2O2) has established itself as a key player in stress and programmed cell death responses, but little is known about the signaling pathways leading from H2O2 to programmed cell death in plants. Recently, identification of key regulatory mutants and near-full genome coverage

  18. Hydrogen, Fuel Cells & Infrastructure Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    2005-03-01

    This plan details the goals, objectives, technical targets, tasks and schedule for EERE's contribution to the DOE Hydrogen Program. Similar detailed plans exist for the other DOE offices that make up the Hydrogen Program.

  19. Bachelor of Science-Engineering Technology Program and Fuel Cell Education Program Concentration

    Energy Technology Data Exchange (ETDEWEB)

    Block, David L. [Florida Solar Energy Center, Cocoa, FL (United States); Sleiti, Ahmad [Univ. of North Carolina, Charlotte, NC (United States)

    2011-09-19

    The Hydrogen and Fuel Cell Technology education project has addressed DOE goals by supplying readily available, objective, technical, and accurate information that is available to students, industry and the public. In addition, the program has supplied educated trainers and training opportunities for the next generation workforce needed for research, development, and demonstration activities in government, industry, and academia. The project has successfully developed courses and associated laboratories, taught the new courses and labs and integrated the HFCT option into the accredited engineering technology and mechanical engineering programs at the University of North Carolina at Charlotte (UNCC). The project has also established ongoing collaborations with the UNCC energy related centers of the Energy Production & Infrastructure Center (EPIC), the NC Motorsports and Automotive Research Center (NCMARC) and the Infrastructure, Design, Environment and Sustainability Center (IDEAS). The results of the project activities are presented as two major areas – (1) course and laboratory development, offerings and delivery, and (2) program recruitment, promotions and collaborations. Over the project period, the primary activity has been the development and offering of 11 HFCT courses and accompanying laboratories. This process has taken three years with the courses first being developed and then offered each year over the timeframe.

  20. Deformable mirrors development program at ESO

    Science.gov (United States)

    Stroebele, Stefan; Vernet, Elise; Brinkmann, Martin; Jakob, Gerd; Lilley, Paul; Casali, Mark; Madec, Pierre-Yves; Kasper, Markus

    2016-07-01

    Over the last decade, adaptive optics has become essential in different fields of research including medicine and industrial applications. With this new need, the market of deformable mirrors has expanded a lot allowing new technologies and actuation principles to be developed. Several E-ELT instruments have identified the need for post focal deformable mirrors but with the increasing size of the telescopes the requirements on the deformable mirrors become more demanding. A simple scaling up of existing technologies from few hundred actuators to thousands of actuators will not be sufficient to satisfy the future needs of ESO. To bridge the gap between available deformable mirrors and the future needs for the E-ELT, ESO started a development program for deformable mirror technologies. The requirements and the path to get the deformable mirrors for post focal adaptive optics systems for the E-ELT is presented.

  1. 1990 fuel cell seminar: Program and abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-31

    This volume contains author prepared short resumes of the presentations at the 1990 Fuel Cell Seminar held November 25-28, 1990 in Phoenix, Arizona. Contained herein are 134 short descriptions organized into topic areas entitled An Environmental Overview, Transportation Applications, Technology Advancements for Molten Carbonate Fuel Cells, Technology Advancements for Solid Fuel Cells, Component Technologies and Systems Analysis, Stationary Power Applications, Marine and Space Applications, Technology Advancements for Acid Type Fuel Cells, and Technology Advancement for Solid Oxide Fuel Cells.

  2. Utility oversight of Cask System Development Program

    International Nuclear Information System (INIS)

    Vincent, J.A.; Jordan, J.M.; Schwartz, M.H.

    1993-01-01

    This paper will present the electric utility industry's perspective on the status and scope of the DOE's Office of Civilian Radioactive Waste Management's (DOE/OCRWM) transportation cask systems development activities, including the Cask Systems Development Program (CSDP) Initiative I transportation cask projects. This presentation is particularly timely because the CSDP Independent Management Review Group (IMRG), os which one of the authors is a member, completed an objective assessment of OCRWM's transportation cask system development activities and issued its first report in late August 1992. The perspective on these cask systems development activities that will be presented reflects conclusions based on (1) the industry's review of CSDP Preliminary and Draft Final Design Reports for the Initiative I cask projects, (2) the activities of one of the authors as a member of the IMRG, and (3) the positions that the industry has consistently taken on what it believes to be the appropriate scope and pace of the CSDP and its integration with other OCRWM activities. Background information on the OCRWM transportation cask systems development activities and the relevant industry activities will also be provided

  3. NASA's Exploration Technology Development Program Energy Storage Project Battery Technology Development

    Science.gov (United States)

    Reid, Concha M.; Miller, Thomas B.; Mercer, Carolyn R.; Jankovsky, Amy L.

    2010-01-01

    Technical Interchange Meeting was held at Saft America s Research and Development facility in Cockeysville, Maryland on Sept 28th-29th, 2010. The meeting was attended by Saft, contractors who are developing battery component materials under contracts awarded through a NASA Research Announcement (NRA), and NASA. This briefing presents an overview of the components being developed by the contractor attendees for the NASA s High Energy (HE) and Ultra High Energy (UHE) cells. The transition of the advanced lithium-ion cell development project at NASA from the Exploration Technology Development Program Energy Storage Project to the Enabling Technology Development and Demonstration High Efficiency Space Power Systems Project, changes to deliverable hardware and schedule due to a reduced budget, and our roadmap to develop cells and provide periodic off-ramps for cell technology for demonstrations are discussed. This meeting gave the materials and cell developers the opportunity to discuss the intricacies of their materials and determine strategies to address any particulars of the technology.

  4. The development of cell lineages: a sequential model.

    Science.gov (United States)

    Brown, G; Bunce, C M; Lord, J M; McConnell, F M

    1988-12-01

    The concept of cell lineage and the empirical characterization of specific lineages provide valuable insight into the problems of developmental biology. Of central interest is the decision-making process that results in the diversification of cell lines. Studies of the haemopoietic system, in which stem cells can be committed to one of at least six pathways of differentiation, have suggested that the restriction of differentiation potentials is a progressive and stochastic process. We have recently proposed an alternative model which hypothesizes that lineage potentials during haemopoiesis are expressed individually and in a predetermined sequence as progenitor cells mature. The model first arises from experimental studies which show that both normal myeloid progenitor cells and a human promyeloid cell line, which are able to differentiate towards either neutrophils or monocytes, express these potentials sequentially in culture. The close linear relationship between other haemopoietic progenitor cells is inferred from collective data from studies of bipotent progenitor cells and of haemopoietic proliferative disorders. If the development of haemopoietic cell lineages shows a tendency to follow a particular program, such a mechanism is likely to operate throughout development. In this paper we consider the evidence in favour of programmed events within progenitor cells implementing diversification, and the implications of predetermined and restricted pathways of embryonic development.

  5. Foetal immune programming: hormones, cytokines, microbes and regulatory T cells.

    Science.gov (United States)

    Hsu, Peter; Nanan, Ralph

    2014-10-01

    In addition to genetic factors, environmental cues play important roles in shaping the immune system. The first environment that the developing foetal immune system encounters is the uterus. Although physically the mother and the foetus are separated by the placental membranes, various factors such as hormones and cytokines may provide "environmental cues" to the foetal immune system. Additionally, increasing evidence suggests that prenatal maternal environmental factors, particularly microbial exposure, might significantly influence the foetal immune system, affecting long-term outcomes, a concept termed foetal immune programming. Here we discuss the potential mediators of foetal immune programming, focusing on the role of pregnancy-related hormones, cytokines and regulatory T cells, which play a critical role in immune tolerance. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  6. Building Technologies Program Multi-Year Program Plan Research and Development 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for research and development, including residential and commercial integration, lighting, HVAC and water heating, envelope, windows, and analysis tools.

  7. Development of PEM fuel cell technology at international fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Wheeler, D.J.

    1996-04-01

    The PEM technology has not developed to the level of phosphoric acid fuel cells. Several factors have held the technology development back such as high membrane cost, sensitivity of PEM fuel cells to low level of carbon monoxide impurities, the requirement to maintain full humidification of the cell, and the need to pressurize the fuel cell in order to achieve the performance targets. International Fuel Cells has identified a hydrogen fueled PEM fuel cell concept that leverages recent research advances to overcome major economic and technical obstacles.

  8. Program Area of Interest: Fuel Transformer Solid Oxide Fuel Cell

    Energy Technology Data Exchange (ETDEWEB)

    Norman Bessette; Douglas S. Schmidt; Jolyon Rawson; Rhys Foster; Anthony Litka

    2006-02-01

    The following report documents the technical approach and conclusions made by Acumentrics Corporation during latest budget period toward the development of a low cost 10kW tubular SOFC power system. The present program, guided under direction from the National Energy Technology Laboratory of the US DOE, is a nine-year cost shared Cooperative Agreement totaling close to $74M funded both by the US DOE as well as Acumentrics Corporation and its partners. The latest budget period ran from July of 2005 through December 2005. Work focused on cell technology enhancements as well as BOP and power electronics improvements and overall system design. Significant progress was made in increasing cell power enhancements as well as decreasing material cost in a drive to meet the SECA cost targets. The following report documents these accomplishments in detail as well as the layout plans for further progress in next budget period.

  9. Programmed cell death in plants: lessons from bacteria?

    Science.gov (United States)

    Wang, Junhui; Bayles, Kenneth W

    2013-03-01

    Programmed cell death (PCD) has well-established roles in the development and physiology of animals, plants, and fungi. Although aspects of PCD control appear evolutionarily conserved between these organisms, the extent of conservation remains controversial. Recently, a putative bacterial PCD protein homolog in plants was found to play a significant role in cell death control, indicating a conservation of function between these highly divergent organisms. Interestingly, these bacterial proteins are thought to be evolutionarily linked to the Bcl-2 family of proteins. In this opinion article, we propose a new unifying model to describe the relationship between bacterial and plant PCD systems and propose that the underlying control of PCD is conserved across at least three Kingdoms of life. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells.

    Science.gov (United States)

    Kilcoyne, Karen R; Smith, Lee B; Atanassova, Nina; Macpherson, Sheila; McKinnell, Chris; van den Driesche, Sander; Jobling, Matthew S; Chambers, Thomas J G; De Gendt, Karel; Verhoeven, Guido; O'Hara, Laura; Platts, Sophie; Renato de Franca, Luiz; Lara, Nathália L M; Anderson, Richard A; Sharpe, Richard M

    2014-05-06

    Fetal growth plays a role in programming of adult cardiometabolic disorders, which in men, are associated with lowered testosterone levels. Fetal growth and fetal androgen exposure can also predetermine testosterone levels in men, although how is unknown, because the adult Leydig cells (ALCs) that produce testosterone do not differentiate until puberty. To explain this conundrum, we hypothesized that stem cells for ALCs must be present in the fetal testis and might be susceptible to programming by fetal androgen exposure during masculinization. To address this hypothesis, we used ALC ablation/regeneration to identify that, in rats, ALCs derive from stem/progenitor cells that express chicken ovalbumin upstream promoter transcription factor II. These stem cells are abundant in the fetal testis of humans and rodents, and lineage tracing in mice shows that they develop into ALCs. The stem cells also express androgen receptors (ARs). Reduction in fetal androgen action through AR KO in mice or dibutyl phthalate (DBP) -induced reduction in intratesticular testosterone in rats reduced ALC stem cell number by ∼40% at birth to adulthood and induced compensated ALC failure (low/normal testosterone and elevated luteinizing hormone). In DBP-exposed males, this failure was probably explained by reduced testicular steroidogenic acute regulatory protein expression, which is associated with increased histone methylation (H3K27me3) in the proximal promoter. Accordingly, ALCs and ALC stem cells immunoexpressed increased H3K27me3, a change that was also evident in ALC stem cells in fetal testes. These studies highlight how a key component of male reproductive development can fundamentally reprogram adult hormone production (through an epigenetic change), which might affect lifetime disease risk.

  11. Development of a VMAT quality assurance program

    International Nuclear Information System (INIS)

    Silva, Ricardo Goulart da

    2013-01-01

    Modern radiation therapy keeps evolving and the technological changes include new imaging modalities, new patient immobilization devices and new treatment delivery systems. These advances have made it possible to reduce the dose to normal tissue structures and consequently minimize the risk of toxicity and morbidity, while allowing for dose escalation to the tumor volumes, potentially leading to improved locoregional control. Traditional IMRT techniques offer all of these features but the treatment session time is usually long, mainly for the head and neck cases. Currently, the VMAT technique is a reality in reference centers around the world. This technology has improved delivery efficiency over IMRT, decreasing the treatment application time, as this modality introduces extra degrees of freedom in the optimization process. The modulation of the radiation beams is achieved by simultaneous variation of dynamic parameters such as dose rate, gantry speed and leaves speed. The high level of complexity associated to the new treatment trends, inevitably, requires more accuracy and more rigorous quality assurance programs. The commissioning methods reported for the Varian RapidArc system were extended to an Elekta Synergy linear accelerator, using custom files built in the iComCAT software. Specific tests for the machine quality assurance are presented and also the dosimetric validation process applied to the Monaco treatment planning system. The MLC parameters, modeled by the Monte Carlo algorithm, were analyzed and the TG 119 tests were adapted for VMAT planning. In the end, a specific program developed for the VMAT technology for Elekta accelerators is presented. (author)

  12. GSG-GIS development program plan

    International Nuclear Information System (INIS)

    Lee, R.C.

    1992-01-01

    For the past 40 years, the Savannah River Site (SRS) has been subjected to numerous geological and geotechnical investigations in support of facility construction and waste site development and remediation. Over this period,.a variety of different subcontractors have collected large quantities of geoscience data. In addition, current programs involve numerous investigators from different departments, and consequently, earth science data and interpretations are scattered among the departments, investigators, and subcontractors at SRS. As a result, scientific and management decisions cannot take advantage of the significant body of information that exists at SRS. Recent DOE Orders (Systematic Evaluation Program, 1991) have put specific requirements on their contractors to compile geological databases to coordinate DOE site data gathering and interpretations, and to assist in compiling safety analysis reports. The Earth Science Advisory Committee and the Environmental Advisory Committee have also made specific recommendations on the management of SRS geoscience data. This plan describes a management system to identify, communicate, and compile SRS geological (including geohydrologic), seismological, and geotechnical (656) data and interpretations on a Geographic Information System (GIS)

  13. D and D technology development program

    International Nuclear Information System (INIS)

    Hyde, J.M.

    1998-01-01

    This paper describes the content of the current program of work for the Deactivation and Decommissioning Focus Area (DDFA) located in the Office of Science and Technology (EM-50). The authors began using large-scale demonstration projects (LSDPs) in 1996 to demonstrate and test innovative decommissioning and decontamination (D and D) technologies in ongoing US Department of Energy (DOE) decommissioning projects. These LSDPs have been conducted in and are planned for different types of DOE facilities such as research and production reactors; highly enriched uranium, tritium, and plutonium processing facilities; fuel reprocessing canyons; weapons production facilities; gaseous diffusion plants; hot cells; and waste processing facilities. The concept has been to focus on addressing DOE's high-priority deactivation and decommissioning needs through the LSDP strategy. In an LSDP, the focus area demonstrates improved technologies side by side with the current baseline technologies in ongoing site decommissioning projects. This approach helps reduce the risk and liability for the DOE users associated with the first-time use of a technology and promotes creative solutions that expand the D and D tool box beyond standard practices and technologies along with other benefits. As of January 1998, more than 50 technologies have been demonstrated covering the areas of characterization, decontamination, dismantlement, waste disposition, stabilization, and health and safety

  14. DOE EM industry programs robotics development

    International Nuclear Information System (INIS)

    Staubly, R.; Kothari, V.

    1998-01-01

    The Office of Science and Technology (OST) manages an aggressive program for RD and D, as well as testing and evaluation for the Department of Energy's (DOE's) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. Robotic systems reduce worker exposure to the absolute minimum, while providing proven, cost-effective, and, for some applications, the only acceptable technique for addressing challenging problems. Development of robotic systems for remote operations occurs in three main categories: tank waste characterization and retrieval; decontamination and dismantlement; and characterization, mapping, and inspection systems. In addition, the Federal Energy Technology Center (FETC) has some other projects which fall under the heading of supporting R and D. The central objective of all FETC robotic projects is to make robotic systems more attractive by reducing costs and health risks associated with the deployment of robotic technologies in the cleanup of the nuclear weapons complex. This will be accomplished through development of robots that are cheaper, faster, safer, and more reliable, as well as more straightforward to modify/adapt and more intuitive to operate with autonomous capabilities and intelligent controls that prevent accidents and optimize task execution

  15. Advancing NOAA NWS Arctic Program Development

    Science.gov (United States)

    Timofeyeva-Livezey, M. M.; Horsfall, F. M. C.; Meyers, J. C.; Churma, M.; Thoman, R.

    2016-12-01

    Environmental changes in the Arctic require changes in the way the National Oceanic and Atmospheric Administration (NOAA) delivers hydrological and meteorological information to prepare the region's societies and indigenous population for emerging challenges. These challenges include changing weather patterns, changes in the timing and extent of sea ice, accelerated soil erosion due to permafrost decline, increasing coastal vulnerably, and changes in the traditional food supply. The decline in Arctic sea ice is opening new opportunities for exploitation of natural resources, commerce, tourism, and military interest. These societal challenges and economic opportunities call for a NOAA integrated approach for delivery of environmental information including climate, water, and weather data, forecasts, and warnings. Presently the NOAA Arctic Task Force provides leadership in programmatic coordination across NOAA line offices. National Weather Service (NWS) Alaska Region and the National Centers for Environmental Prediction (NCEP) provide the foundational operational hydro-meteorological products and services in the Arctic. Starting in 2016, NOAA's NWS will work toward improving its role in programmatic coordination and development through assembling an NWS Arctic Task Team. The team will foster ties in the Arctic between the 11 NWS national service programs in climate, water, and weather information, as well as between Arctic programs in NWS and other NOAA line offices and external partners. One of the team outcomes is improving decision support tools for the Arctic. The Local Climate Analysis Tool (LCAT) currently has more than 1100 registered users, including NOAA staff and technical partners. The tool has been available online since 2013 (http://nws.weather.gov/lcat/ ). The tool links trusted, recommended NOAA data and analytical capabilities to assess impacts of climate variability and climate change at local levels. A new capability currently being developed will

  16. Program for developing leadership in pharmacy residents.

    Science.gov (United States)

    Fuller, Patrick D

    2012-07-15

    An innovative, structured approach to incorporating leadership development activities into pharmacy residency training is described. The American Society of Health-System Pharmacists (ASHP) has called for increased efforts to make leadership development an integral component of the training of pharmacy students and new practitioners. In 2007, The Nebraska Medical Center (TNMC) took action to systematize leadership training in its pharmacy residency programs by launching a new Leadership Development Series. Throughout the residency year, trainees at TNMC participate in a variety of activities: (1) focused group discussions of selected articles on leadership concepts written by noted leaders of the past and present, (2) a two-day offsite retreat featuring trust-building exercises and physical challenges, (3) a self-assessment designed to help residents identify and use their untapped personal strengths, (4) training on the effective application of different styles of communication and conflict resolution, and (5) education on the history and evolution of health-system pharmacy, including a review and discussion of lectures by recipients of ASHP's Harvey A. K. Whitney Award. Feedback from residents who have completed the series has been positive, with many residents indicating that it has stimulated their professional growth and helped prepared them for leadership roles. A structured Leadership Development Series exposes pharmacy residents to various leadership philosophies and principles and, through the study of Harvey A. K. Whitney Award lectures, to the thoughts of past and present pharmacy leaders. Residents develop an increased self-awareness through a resident fall retreat, a StrengthsFinder assessment, and communication and conflict-mode assessment tools.

  17. The Tr-cp 14 cysteine protease in white clover (Trifolium repens) is localized to the endoplasmic reticulum and is associated with programmed cell death during development of tracheary elements

    DEFF Research Database (Denmark)

    Mulisch, Maria; Asp, Torben; Krupinska, Karin

    2013-01-01

    Cysteine proteases are known to be associated with programmed cell death, developmental senescence and some types of pathogen and stress-induced responses. In the present study, we have characterized the cysteine protease Tr-cp 14 in white clover (Trifolium repens). Tr-cp 14 belongs to the C1A...

  18. Single cell transcriptome profiling of developing chick retinal cells.

    Science.gov (United States)

    Laboissonniere, Lauren A; Martin, Gregory M; Goetz, Jillian J; Bi, Ran; Pope, Brock; Weinand, Kallie; Ellson, Laura; Fru, Diane; Lee, Miranda; Wester, Andrea K; Liu, Peng; Trimarchi, Jeffrey M

    2017-08-15

    The vertebrate retina is a specialized photosensitive tissue comprised of six neuronal and one glial cell types, each of which develops in prescribed proportions at overlapping timepoints from a common progenitor pool. While each of these cells has a specific function contributing to proper vision in the mature animal, their differential representation in the retina as well as the presence of distinctive cellular subtypes makes identifying the transcriptomic signatures that lead to each retinal cell's fate determination and development challenging. We have analyzed transcriptomes from individual cells isolated from the chick retina throughout retinogenesis. While we focused our efforts on the retinal ganglion cells, our transcriptomes of developing chick cells also contained representation from multiple retinal cell types, including photoreceptors and interneurons at different stages of development. Most interesting was the identification of transcriptomes from individual mixed lineage progenitor cells in the chick as these cells offer a window into the cell fate decision-making process. Taken together, these data sets will enable us to uncover the most critical genes acting in the steps of cell fate determination and early differentiation of various retinal cell types. © 2017 Wiley Periodicals, Inc.

  19. Toward Continuous Program Improvement: Using a Logic Model for Professional Development School Program Evaluation

    Science.gov (United States)

    He, Ye; Rohr, Jean; Miller, Samuel D.; Levin, Barbara B.; Mercier, Susan

    2010-01-01

    The purpose of this study was to develop a model for evaluating a professional development school program to enact an evidence-based model for a continuous cycle of program improvement. Guided by the logic model for program evaluation, we developed three survey instruments based on the professional development school standards of the National…

  20. Regional Program Assistant | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Job Summary Under the general direction of the assigned Program Officers situated in ROSSA, the Regional Program Assistant provides a variety of administrative, coordination, logistical and information management services in support of the various program operations. The incumbent is responsible for prioritizing and ...

  1. Developing an Information and Records Management Program.

    Science.gov (United States)

    Rutledge, Juli G.; Kartis, Alexia M.

    1984-01-01

    The need for information controls for college records management programs and the elements of program organization, planning, and management are discussed. Conditions at institutions that indicate a flaw in information control are identified, along with the benefits of a sound records management program. The management of an information and…

  2. Program Management Officer | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Job Summary Working under the supervision of a manager, the Program Management Officer contributes to the operation of a research program, produces documentation, and coordinates and disseminates information in support of the program management. The principal responsibilities include knowledge management, ...

  3. Progress in developing ultrathin solar cell blanket technology

    Science.gov (United States)

    Patterson, R. E.; Mesch, H. G.; Scott-Monck, J.

    1984-01-01

    A program was conducted to develop technologies for welding interconnects to three types of 50-micron-thick, 2 by 2-cm solar cells. Parallel-gap resistance welding was used for interconnect attachment. Weld schedules were independently developed for each of the three cell types and were coincidentally identical. Six 48-cell modules were assembled with 50-micron (nominal) thick cells, frosted fused-silica covers, silver-plated Invar interconnectors, and four different substrate designs. Three modules (one for each cell type) have single-layer Kapton (50-micron-thick) substrates. The other three modules each have a different substrate (Kapton-Kevlar-Kapton, Kapton-graphite-Kapton, and Kapton-graphite-aluminum honeycomb-graphite). All six modules were subjected to 4112 thermal cycles from -175 to 65 C (corresponding to over 40 years of simulated geosynchronous orbit thermal cycling) and experienced only negligible electrical degradation (1.1 percent average of six 48-cell modules).

  4. Hot Dry Rock Geothermal Energy Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.C.; Hendron, R.H.; Murphy, H.D.; Wilson, M.G.

    1989-12-01

    During Fiscal Year 1987, emphasis in the Hot Dry Rock Geothermal Energy Development Program was on preparations for a Long-Term Flow Test'' of the Phase II'' or Engineering'' hot dry rock energy system at Fenton Hill, New Mexico. A successful 30-day flow test of the system during FY86 indicated that such a system would produce heat at a temperature and rate that could support operation of a commercial electrical power plant. However, it did not answer certain questions basic to the economics of long-term operation, including the rate of depletion of the thermal reservoir, the rate of water loss from the system, and the possibility of operating problems during extended continuous operation. Preparations for a one-year flow test of the system to answer these and more fundamental questions concerning hot dry rock systems were made in FY87: design of the required surface facilities; procurement and installation of some of their components; development and testing of slimline logging tools for use through small-diameter production tubing; research on temperature-sensitive reactive chemical tracers to monitor thermal depletion of the reservoir; and computer simulations of the 30-day test, extended to modeling the planned Long-Term Flow Test. 45 refs., 34 figs., 5 tabs.

  5. Developing Online Family Life Prevention and Education Programs

    Science.gov (United States)

    Hughes, Robert, Jr.; Bowers, Jill R.; Mitchell, Elissa Thomann; Curtiss, Sarah; Ebata, Aaron T.

    2012-01-01

    Although numerous online family life education programs have been developed over the past few years, there has been little discussion about best practices in the development of these programs. This article presents a framework to assist family life educators in the development and improvement of online programs from the initial problem analysis…

  6. Programmed Cell Death and Complexity in Microbial Systems.

    Science.gov (United States)

    Durand, Pierre M; Sym, Stuart; Michod, Richard E

    2016-07-11

    Programmed cell death (PCD) is central to organism development and for a long time was considered a hallmark of multicellularity. Its discovery, therefore, in unicellular organisms presents compelling questions. Why did PCD evolve? What is its ecological effect on communities? To answer these questions, one is compelled to consider the impacts of PCD beyond the cell, for death obviously lowers the fitness of the cell. Here, we examine the ecological effects of PCD in different microbial scenarios and conclude that PCD can increase biological complexity. In mixed microbial communities, the mode of death affects the microenvironment, impacting the interactions between taxa. Where the population comprises groups of relatives, death has a more explicit effect. Death by lysis or other means can be harmful, while PCD can evolve by providing advantages to relatives. The synchronization of death between individuals suggests a group level property is being maintained and the mode of death also appears to have had an impact during the origin of multicellularity. PCD can result in the export of fitness from the cell to the group level via re-usable resources and PCD may also provide a mechanism for how groups beget new groups comprising kin. Furthermore, PCD is a means for solving a central problem of group living - the toxic effects of death - by making resources in dying cells beneficial to others. What emerges from the data reviewed here is that while PCD carries an obvious cost to the cell, it can be a driver of complexity in microbial communities. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM: FUEL CELLS

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) Program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This techno...

  8. Cell to cell signalling during vertebrate limb bud development

    NARCIS (Netherlands)

    Panman, Lia

    2004-01-01

    Communication between cells is essential during embryonic development. The vertebrate limb bud provides us a model to study signalling interactions between cells during patterning of embryonic tissues and organogenesis. In chapter 1 I give an introduction about limb bud development that is focussed

  9. Programmed cell death for defense against anomaly and tumor formation

    International Nuclear Information System (INIS)

    Kondo, Sohei; Norimura, Toshiyuki; Nomura, Taisei

    1995-01-01

    Cell death after exposure to low-level radiation is often considered evidence that radiation is poisonous, however small the dose. Evidence has been accumulating to support the notion that cell death after low-level exposure to radiation results from activation of suicidal genes open-quote programmed cell death close-quote or open-quote apoptosis close-quote - for the health of the whole body. This paper gives experimental evidence that embryos of fruit flies and mouse fetuses have potent defense mechanisms against teratogenic or tumorigenic injury caused by radiation and carcinogens, which function through programmed cell death

  10. Cell cycle in egg cell and its progression during zygotic development in rice.

    Science.gov (United States)

    Sukawa, Yumiko; Okamoto, Takashi

    2018-03-01

    Rice egg is arrested at G1 phase probably by OsKRP2. After fusion with sperm, karyogamy, OsWEE1-mediated parental DNA integrity in zygote nucleus, zygote progresses cell cycle to produce two-celled embryo. In angiosperms, female and male gametes exist in gametophytes after the complementation of meiosis and the progression of nuclear/cell division of the haploid cell. Within the embryo sac, the egg cell is specially differentiated for fertilization and subsequent embryogenesis, and cellular programs for embryonic development, such as restarting the cell cycle and de novo gene expression, are halted. There is only limited knowledge about how the cell cycle in egg cells restarts toward zygotic division, although the conversion of the cell cycle from a quiescent and arrested state to an active state is the most evident transition of cell status from egg cell to zygote. This is partly due to the difficulty in direct access and analysis of egg cells, zygotes and early embryos, which are deeply embedded in ovaries. In this study, precise relative DNA amounts in the nuclei of egg cells, developing zygotes and cells of early embryos were measured, and the cell cycle of a rice egg cell was estimated as the G1 phase with a 1C DNA level. In addition, increases in DNA content in zygote nuclei via karyogamy and DNA replication were also detectable according to progression of the cell cycle. In addition, expression profiles for cell cycle-related genes in egg cells and zygotes were also addressed, and it was suggested that OsKRP2 and OsWEE1 function in the inhibition of cell cycle progression in egg cells and in checkpoint of parental DNA integrity in zygote nucleus, respectively.

  11. A Conserved Core of Programmed Cell Death Indicator Genes Discriminates Developmentally and Environmentally Induced Programmed Cell Death in Plants.

    Science.gov (United States)

    Olvera-Carrillo, Yadira; Van Bel, Michiel; Van Hautegem, Tom; Fendrych, Matyáš; Huysmans, Marlies; Simaskova, Maria; van Durme, Matthias; Buscaill, Pierre; Rivas, Susana; Coll, Nuria S.; Coppens, Frederik; Maere, Steven; Nowack, Moritz K.

    2015-12-01

    A plethora of diverse programmed cell death (PCD) processes has been described in living organisms. In animals and plants, different forms of PCD play crucial roles in development, immunity, and responses to the environment. While the molecular control of some animal PCD forms such as apoptosis is known in great detail, we still know comparatively little about the regulation of the diverse types of plant PCD. In part, this deficiency in molecular understanding is caused by the lack of reliable reporters to detect PCD processes. Here, we addressed this issue by using a combination of bioinformatics approaches to identify commonly regulated genes during diverse plant PCD processes in Arabidopsis (Arabidopsis thaliana). Our results indicate that the transcriptional signatures of developmentally controlled cell death are largely distinct from the ones associated with environmentally induced cell death. Moreover, different cases of developmental PCD share a set of cell death-associated genes. Most of these genes are evolutionary conserved within the green plant lineage, arguing for an evolutionary conserved core machinery of developmental PCD. Based on this information, we established an array of specific promoter-reporter lines for developmental PCD in Arabidopsis. These PCD indicators represent a powerful resource that can be used in addition to established morphological and biochemical methods to detect and analyze PCD processes in vivo and in planta. © 2015 American Society of Plant Biologists. All Rights Reserved.

  12. Switching and programming dynamics in phase-change memory cells

    Science.gov (United States)

    Ielmini, D.; Mantegazza, D.; Lacaita, A. L.; Pirovano, A.; Pellizzer, F.

    2005-11-01

    Emerging phase-change memory (PCM) technology for non-volatile applications presents many potential advantages in terms of scalability, endurance and program/read speed. While several integration issues have still to be solved before achieving volume-production stage, the fundamental physics of chalcogenide switching and phase-change behaviour has still to be comprehensively understood. This paper provides an in-depth analysis of the switching and programming transient in PCM cells. It is shown that the cell parasitic capacitance can lead to a marked current overshoot in the programming transient. As evidenced by experiments, this overshoot is able to melt and quench the active material as in a reset operation. The parasitic reset results in a series distribution of crystalline and amorphous phases after program. The analysis of array cell capacitance instead indicates that no parasitic reset is to be expected, allowing for a localized crystallization during program, as previously obtained by numerical simulations.

  13. Mobile fuel cell development at Siemens

    Science.gov (United States)

    Strasser, K.

    1992-01-01

    Recent mobile fuel cell developments are reported with particular attention given to fuel cell technology based on photon exchange membrane (PEM) as electrolyte. Advantages of PEM fuel cells over conventional systems include their overload capacity, low power degradation, long lifetime, and the possibility to operate the fuel cell at different temperatures. The PEM fuel cells can be operated with CO2-containing reactants and have a considerable potential for increasing power. These facts make it possible to construct energy storage systems with H2/air fuel cells for electric cars or long-term storage facilities for regenerative energy systems.

  14. Applying QA to nuclear-development programs

    International Nuclear Information System (INIS)

    Caplinger, W.H.

    1981-12-01

    The application of quality assurance (QA) principles to developmental programs is usually accomplished by tailoring or selecting appropriate requirements from large QA systems. Developmental work at Westinghouse Hanford Company (WHC) covers the complete range from basic research to in-core reactor tests. Desired requirements are selected from the 18 criteria in ANSI/ASME NQA Standard 1 by the cognizant program engineer in conjunction with the quality engineer. These referenced criteria assure that QA for the program is planned, implemented, and maintained. In addition, the WHC QA Manual provides four categories or levels of QA that are assigned to programs or components within the program. These categories are based on safety, reliability, and consequences of failure to provide a cost effective program

  15. National fuel cell bus program : proterra fuel cell hybrid bus report, Columbia demonstration.

    Science.gov (United States)

    2011-10-01

    This report summarizes the experience and early results from a fuel cell bus demonstration funded by the Federal Transit Administration (FTA) under the National Fuel Cell Bus Program. A team led by the Center for Transportation and the Environment an...

  16. Space Station Freedom NiH2 cell testing program

    Science.gov (United States)

    Moore, Bruce; Frate, Dave

    1994-02-01

    Testing for the Space Station Freedom Nickel Hydrogen Cell Test Program began in 1990 at Crave Division, Naval Surface Warfare Center. The program has included receipt inspection, random vibration, acceptance, characterization, and life cycle testing of Ni-H2 cells in accordance with the NASA LeRC Interagency Order C-31001-J. A total of 400 Ni-H2 cells have been received at NAVSURFWARCENDIV Crane from three separate manufacturers; Yardney Technical Products (Yardney), Eagle Picher Industries (Eagle Picher), and Gates Energy Products (Gates). Of those, 308 cells distributed among 39 packs have undergone life cycle testing under a test regime simulating low earth orbit conditions. As of 30 September 1993, there are 252 cells assembled into 32 packs still on life cycle test. Since the beginning of the program, failed cells have been detected in all phases of testing. The failures include the following; seven 65 AmpHr and 81 AmpHr Yardney cells were found to be leaking KOH on receipt, one 65 AmpHr Eagle Picher cell failed the acceptance test, one 65 AmpHr Gates cell failed during the characterization test, and six 65 AmpHr Gates cells failed the random vibration test. Of the 39 life cycle packs, testing on seven packs, 56 cells, has been suspended because of low end of discharge voltages. All of the failed life cycle packs were cycled at 60% depth of discharge.

  17. Hydrogen hybrid vehicle engine development: Experimental program

    Energy Technology Data Exchange (ETDEWEB)

    Van Blarigan, P. [Sandia National Lab., Livermore, CA (United States)

    1995-09-01

    A hydrogen fueled engine is being developed specifically for the auxiliary power unit (APU) in a series type hybrid vehicle. Hydrogen is different from other internal combustion (IC) engine fuels, and hybrid vehicle IC engine requirements are different from those of other IC vehicle engines. Together these differences will allow a new engine design based on first principles that will maximize thermal efficiency while minimizing principal emissions. The experimental program is proceeding in four steps: (1) Demonstration of the emissions and the indicated thermal efficiency capability of a standard CLR research engine modified for higher compression ratios and hydrogen fueled operation. (2) Design and test a new combustion chamber geometry for an existing single cylinder research engine, in an attempt to improve on the baseline indicated thermal efficiency of the CLR engine. (3) Design and build, in conjunction with an industrial collaborator, a new full scale research engine designed to maximize brake thermal efficiency. Include a full complement of combustion diagnostics. (4) Incorporate all of the knowledge thus obtained in the design and fabrication, by an industrial collaborator, of the hydrogen fueled engine for the hybrid vehicle power train illustrator. Results of the CLR baseline engine testing are presented, as well as preliminary data from the new combustion chamber engine. The CLR data confirm the low NOx produced by lean operation. The preliminary indicated thermal efficiency data from the new combustion chamber design engine show an improvement relative to the CLR engine. Comparison with previous high compression engine results shows reasonable agreement.

  18. Program to Develop Abilities in Sustainable Venture

    Directory of Open Access Journals (Sweden)

    Ligia Coromoto Castro Nava

    2016-11-01

    Full Text Available This research aims to promote a program of abilities in sustainable venture for the third year students of the Francisco Tamayo School Technical located in Barinitas parish, Bolívar municipality state Barinas. Because of each school year shows desertion of studies cases and there is not the existence of actions to improve education specifically related to the sustainable venture that reinforce the bond between the training and working world. This investigation points to open opportunities on social and working inclusion. The nature of this study belongs to the qualitative approach of a participatory action research. It supports the field method and its methodological design was made in four phases: Reflection, Planning, Execution Plan, Scopes and Limitations, Reflection and Results. The key people will be: (01 student and (02 teachers. The technique of gathering information will be the observation and the deep interview. The analysis techniques of information were categorization, triangulation and interpretation. Among the preliminary considerations are expected abilities and skills acquisition to perform any activity that gain incomes. This fact will help students to cover their economic and familiar needs to complement personal development.

  19. Cytoview: Development of a cell modelling framework

    Indian Academy of Sciences (India)

    2007-07-06

    Jul 6, 2007 ... Home; Journals; Journal of Biosciences; Volume 32; Issue 5. Cytoview: Development of a cell modelling framework ... The framework serves as a first step in integrating different levels of data available for a biological cell and has the potential to lead to development of computational models in our pursuit to ...

  20. Keeping the Rhythm : Cardiac Pacemaker Cell Development

    NARCIS (Netherlands)

    Burkhard, Silja

    2017-01-01

    The heart is the first organ to form and function in the developing vertebrate embryo. Its proper morphogenesis and function is crucial for survival. Here we focus on the development and characterization of a highly specialized subset of cardiac cells, the pacemaker cells. In the mammalian heart,

  1. 2013 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-12-01

    The 2013 Annual Progress Report summarizes fiscal year 2013 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; market transformation; and systems analysis.

  2. 2014 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-11-01

    The 2014 Annual Progress Report summarizes fiscal year 2014 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; market transformation; and systems analysis.

  3. 2011 Annual Progress Report: DOE Hydrogen and Fuel Cells Program

    Energy Technology Data Exchange (ETDEWEB)

    Satyapal, Sunita [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-11-01

    The 2011 Annual Progress Report summarizes fiscal year 2011 activities and accomplishments by projects funded by the DOE Hydrogen Program. It covers the program areas of hydrogen production and delivery; hydrogen storage; fuel cells; manufacturing; technology validation; safety, codes and standards; education; market transformation; and systems analysis.

  4. Changes in gene expression during programmed cell death in tomato cell suspensions

    NARCIS (Netherlands)

    Hoeberichts, F.A.; Orzaez, D.; Plas, van der L.H.W.; Woltering, E.J.

    2001-01-01

    To identify genes involved in plant programmed cell death (PCD), changes in gene expression during PCD in a model system of suspension-cultured tomato cells were studied. In this system, cell death is triggered by treatment with camptothecin, an inhibitor of topoisomerase I. Cell death was

  5. Programmed cell death in the plant immune system.

    Science.gov (United States)

    Coll, N S; Epple, P; Dangl, J L

    2011-08-01

    Cell death has a central role in innate immune responses in both plants and animals. Besides sharing striking convergences and similarities in the overall evolutionary organization of their innate immune systems, both plants and animals can respond to infection and pathogen recognition with programmed cell death. The fact that plant and animal pathogens have evolved strategies to subvert specific cell death modalities emphasizes the essential role of cell death during immune responses. The hypersensitive response (HR) cell death in plants displays morphological features, molecular architectures and mechanisms reminiscent of different inflammatory cell death types in animals (pyroptosis and necroptosis). In this review, we describe the molecular pathways leading to cell death during innate immune responses. Additionally, we present recently discovered caspase and caspase-like networks regulating cell death that have revealed fascinating analogies between cell death control across both kingdoms.

  6. Programmed cell death in C. elegans, mammals and plants.

    Science.gov (United States)

    Lord, Christina E N; Gunawardena, Arunika H L A N

    2012-08-01

    Programmed cell death (PCD) is the regulated removal of cells within an organism and plays a fundamental role in growth and development in nearly all eukaryotes. In animals, the model organism Caenorhabditis elegans (C. elegans) has aided in elucidating many of the pathways involved in the cell death process. Various analogous PCD processes can also be found within mammalian PCD systems, including vertebrate limb development. Plants and animals also appear to share hallmarks of PCD, both on the cellular and molecular level. Cellular events visualized during plant PCD resemble those seen in animals including: nuclear condensation, DNA fragmentation, cytoplasmic condensation, and plasma membrane shrinkage. Recently the molecular mechanisms involved in plant PCD have begun to be elucidated. Although few regulatory proteins have been identified as conserved across all eukaryotes, molecular features such as the participation of caspase-like proteases, Bcl-2-like family members and mitochondrial proteins appear to be conserved between plant and animal systems. Transgenic expression of mammalian and C. elegans pro- and anti-apoptotic genes in plants has been observed to dramatically influence the regulatory pathways of plant PCD. Although these genes often show little to no sequence similarity they can frequently act as functional substitutes for one another, thus suggesting that action may be more important than sequence resemblance. Here we present a summary of these findings, focusing on the similarities, between mammals, C. elegans, and plants. An emphasis will be placed on the mitochondria and its role in the cell death pathway within each organism. Through the comparison of these systems on both a cellular and molecular level we can begin to better understand PCD in plant systems, and perhaps shed light on the pathways, which are controlling the process. This manuscript adds to the field of PCD in plant systems by profiling apoptotic factors, to scale on a protein

  7. Development of parallel/serial program analyzing tool

    International Nuclear Information System (INIS)

    Watanabe, Hiroshi; Nagao, Saichi; Takigawa, Yoshio; Kumakura, Toshimasa

    1999-03-01

    Japan Atomic Energy Research Institute has been developing 'KMtool', a parallel/serial program analyzing tool, in order to promote the parallelization of the science and engineering computation program. KMtool analyzes the performance of program written by FORTRAN77 and MPI, and it reduces the effort for parallelization. This paper describes development purpose, design, utilization and evaluation of KMtool. (author)

  8. Vacuolar processing enzyme in plant programmed cell death

    Directory of Open Access Journals (Sweden)

    Noriyuki eHatsugai

    2015-04-01

    Full Text Available Vacuolar processing enzyme (VPE is a cysteine proteinase originally identified as the proteinase responsible for the maturation and activation of vacuolar proteins in plants, and it is known to be an orthologue of animal asparaginyl endopeptidase (AEP/VPE/legumain. VPE has been shown to exhibit enzymatic properties similar to that of caspase 1, which is a cysteine protease that mediates the programmed cell death (PCD pathway in animals. Although there is limited sequence identity between VPE and caspase 1, their predicted three-dimensional structures revealed that the essential amino-acid residues for these enzymes form similar pockets for the substrate peptide YVAD. In contrast to the cytosolic localization of caspases, VPE is localized in vacuoles. VPE provokes vacuolar rupture, initiating the proteolytic cascade leading to PCD in the plant immune response. It has become apparent that the VPE-dependent PCD pathway is involved not only in the immune response, but also in the responses to a variety of stress inducers and in the development of various tissues. This review summarizes the current knowledge on the contribution of VPE to plant PCD and its role in vacuole-mediated cell death, and it also compares VPE with the animal cell death executor caspase 1.

  9. New Sunshine Program for fiscal 2000. Development of photovoltaic power system commercialization technology (Development of ultrahigh-efficiency crystalline compound solar cell manufacturing technology - Surveys and studies of peripheral key technologies/Surveys of environmentally-friendliness enhancement for next-generation solar cell development); 2000 nendo New sunshine keikaku seika hokokusho. Taiyoko hatsuden system jitsuyoka gijutsu kaihatsu - Chokokoritsu kessho kagobutsu taiyo denchi no seizo gijutsu kaihatsu (Shuhen yoso gijutsu ni kansuru kenkyu chosa, Jisedai taiyodenchi kaihatsu kankyo tekioka chosa)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Though the trends of solar cell development are becoming increasingly diverse across the world, yet none has emerged to promise a stable solar cell supply in the future. Under the circumstances, studies were conducted to clarify strategies for solar cell technology development which would be well adapted to Japan's social environments, with the trends of development in the United States and European countries taken into consideration. The surveys covered the research and development and diffusion of photovoltaic power generation in the United States and European countries, and their solar cell research and development strategies and trends of development were put together. Surveys were also conducted into the research and development of unconventional types of solar cells, such as the dye-sensitized solar cell, organic solar cell, conjugate polymer solar cell, and the polymer/C{sub 60} based solar cell, and into the status of resources of materials for solar cells such as gallium, arsenic, cadmium, tellurium, indium, selenium, and germanium. Regarding the future of photovoltaic power generation research and development, it was concluded that commercialization technology development and basic research and development should continue. Also pointed out was the importance of the enlargement of the market for photovoltaic power generation systems. (NEDO)

  10. TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells

    International Nuclear Information System (INIS)

    Voigt, Susann; Kalthoff, Holger; Adam, Dieter; Philipp, Stephan; Davarnia, Parvin; Winoto-Morbach, Supandi; Röder, Christian; Arenz, Christoph; Trauzold, Anna; Kabelitz, Dieter; Schütze, Stefan

    2014-01-01

    represent a promising new option for the future development of combination therapies. Our data also suggest that RIPK3 expression may serve as a potential predictive marker for the sensitivity of tumor cells to programmed necrosis and extend the previously established role of ceramide as a key mediator of death receptor-induced programmed necrosis (and thus as a potential target for future therapies) also to the tumor cell lines examined here

  11. Mitochondrial apoptotic pathways induced by Drosophila programmed cell death regulators

    International Nuclear Information System (INIS)

    Claveria, Cristina; Torres, Miguel

    2003-01-01

    Multicellular organisms eliminate unwanted or damaged cells by cell death, a process essential to the maintenance of tissue homeostasis. Cell death is a tightly regulated event, whose alteration by excess or defect is involved in the pathogenesis of many diseases such as cancer, autoimmune syndromes, and neurodegenerative processes. Studies in model organisms, especially in the nematode Caenorhabditis elegans, have been crucial in identifying the key molecules implicated in the regulation and execution of programmed cell death. In contrast, the study of cell death in Drosophila melanogaster, often an excellent model organism, has identified regulators and mechanisms not obviously conserved in other metazoans. Recent molecular and cellular analyses suggest, however, that the mechanisms of action of the main programmed cell death regulators in Drosophila include a canonical mitochondrial pathway

  12. Fusion Energy Postdoctoral Research Program, Professional Development Program: FY 1987 annual report

    International Nuclear Information System (INIS)

    1988-01-01

    In FY 1986, Oak Ridge Associated Universities (ORAU) initiated two programs for the US Department of Energy (DOE), Office of Fusion Energy (OFE): the Fusion Energy Postdoctoral Research Program and the Fusion Energy Professional Development Program. These programs provide opportunities to conduct collaborative research in magnetic fusion energy research and development programs at DOE laboratories and contractor sites. Participants become trained in advanced fusion energy research, interact with outstanding professionals, and become familiar with energy-related national issues while making personal contributions to the search for solutions to scientific problems. Both programs enhance the national fusion energy research and development effort by providing channels for the exchange of scientists and engineers, the diffusion of ideas and knowledge, and the transfer of relevant technologies. These programs, along with the Magnetic Fusion Energy Science and Technology Fellowship Programs, compose the fusion energy manpower development programs administered by ORAU for DOE/OFE

  13. American fuel cell market development

    Science.gov (United States)

    Gillis, E. A.

    1992-01-01

    Over the past three decades several attempts have been made to introduce fuel cells into commercial markets. The prospective users recognized the attractive features of fuel cells, however they were unwilling to pay a premium for the features other than the easily-calculated fuel cost savings. There was no accepted method for a user to calculate and the accrue the economic value of the other features. The situation is changing. The Clean Air Act signed into law by President Bush on November 15, 1990, mandates a nation wide reduction in SO 2, NO x and ozone emissions. This law affects specific utilities for SO 2 reduction, and specific regions of the country for NO x and ozone reductions — the latter affecting the utility-, industrial- and transportation-sectors in these regions. The Act does not direct how the reductions are to be achieved; but it specifically establishes a trading market for emission allowances whereby an organization that reduces emissions below its target can sell its unused allowance to another organization. In addition to the Clean Air Act, there are other environmental issues emerging such as controls on CO 2 emissions, possible expansion of the list of controlled emissions, mandated use of alternative fuels in specific transportation districts and restrictions on electrical transmission systems. All of these so-called 'environmental externalities' are now recognized as having a real cost that can be quantified, and factored in to calculations to determine the relative economic standing of various technologies. This in turn justifies a premium price for fuel cells hence the renewed interest in the technology by the utility and transportation market segments.

  14. The United States Advanced Reactor Technologies Research and Development Program

    International Nuclear Information System (INIS)

    O’Connor, Thomas J.

    2014-01-01

    The following aspects are addressed: • Nuclear energy mission; • Reactor research development and deployment (RD&D) programs: - Light Water Reactor Sustainability Program; - Small Modular Reactor Licensing Technical Support; - Advanced Reactor Technologies (ART)

  15. Long Life, High Energy Cell Development Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA has a need to develop higher energy density battery systems to meet the power requirements of future energy devices. In this proposed Phase I program, PSI will...

  16. Endoderm Generates Endothelial Cells during Liver Development

    Directory of Open Access Journals (Sweden)

    Orit Goldman

    2014-10-01

    Full Text Available Organogenesis requires expansion of the embryonic vascular plexus that migrates into developing organs through a process called angiogenesis. Mesodermal progenitors are thought to derive endothelial cells (ECs that contribute to both embryonic vasculogenesis and the subsequent organ angiogenesis. Here, we demonstrate that during development of the liver, which is an endoderm derivative, a subset of ECs is generated from FOXA2+ endoderm-derived fetal hepatoblast progenitor cells expressing KDR (VEGFR2/FLK-1. Using human and mouse embryonic stem cell models, we demonstrate that KDR+FOXA2+ endoderm cells developing in hepatic differentiation cultures generate functional ECs. This introduces the concept that ECs originate not exclusively from mesoderm but also from endoderm, supported in Foxa2 lineage-tracing mouse embryos by the identification of FOXA2+ cell-derived CD31+ ECs that integrate the vascular network of developing fetal livers.

  17. Fuel cell energy service Enron`s commerical program

    Energy Technology Data Exchange (ETDEWEB)

    Jacobson, M.W.

    1996-04-01

    Enron, the premier provider of clean fuels worldwide, has launched a unique energy service based on fuel cell technology. The goal of this program is to bring the benefits of fuel cell power to the broad commercial marketplace. Enron`s Energy Service is currently based on a 200 kilowatt phosphoric acid power plant manufactured by ONSI Corporation. This plant is fueled by natural gas or propane, and exhibits superior performance. Enron offers a `no hassle` package that provides customers with immediate benefits with no upfront capital or technical risks. This paper describes Enron`s fuel cell commercial program.

  18. Establishing a Communications Officer Force Development Program

    National Research Council Canada - National Science Library

    Jenrette, Brian J

    2006-01-01

    ...: experience, skills, training, education, and performance feedback. However, the Air Force has not instituted the structure, supplied the resources, or mandated the governance to make the program a success...

  19. [Program optimization before enucleation on ovine somatic cell nuclear transfer].

    Science.gov (United States)

    Guo, Yanhua; Zhang, Yiyuan; Wang, Limin; Tang, Hong; Li, Yingli; Zhou, Ping

    2017-05-25

    Ovine somatic cell nuclear transfer (SCNT) efficiency remains lower. Therefore, we optimized the program before oocyte enucleation on ovine SCNT. Four experiments were done including exposure duration of ovaries (3 h or 3 to 5 h), duration of oocytes maturation (18 h and 24 h), rate of donor adherent and enucleation time of maturate oocyte. The maturation rates of oocyte, fusion rates and cleavation rates of cloned embryos were used to assess the efficiency of different procedures. The maturation rates of ovaries with 3 h exposure was higher than that of 3 to 5 h (60.18% vs 52.50%) (P0.05). The maturation rates were significantly different between group18 h and 24 h (53.81% vs 89.06%, P0.05); fusion rates of donor adherent 30% group was higher than that of 10% group. Embryonic development competence had no significant difference (P>0.05). Different adherent donor characterizes the difference in plateau phase. The cleavation rates of 18 hpm group was higher than that of 16 hpm group. Embryonic development competence had no significant difference (P>0.05), the enucleation of 16 hpm group obtained one clone fetus, we got four clone fetus to repeat the 16 hpm group. Five microsatellite was analyzed by PAGE, the bands indicated that fingerprint of cloned fetus were completely the same as those of donor cells. Our data therefore suggests program optimization before enucleation assurance quality of material which be able to improve the quantity and quality of clone embryos, and optimized scheme can obtain clone sheep offspring.

  20. Program Development Plan and Team up

    Energy Technology Data Exchange (ETDEWEB)

    Solar Electric Power Association

    2001-12-01

    The final summary report is a comprehensive view of TEAM-UP, with documented data, information, and experiences that SEPA has collected throughout the program, including lessons learned by participating ventures, and sections covering costs and other information on both large and small systems. This report also covers the barriers that TEAM-UP faced to PV commercialization at the beginning of the program, barriers the project was able to remove or reduce, and what barriers remain on the road ahead.

  1. Baseline Gas Turbine Development Program. Fourteenth quarterly progress report

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, F W; Wagner, C E

    1976-04-30

    Progress is reported for a Baseline Gas Turbine Development Program sponsored by the Heat Engine Systems Branch, Division of Transportation Energy Conservation (TEC) of the Energy Research and Development Administration (ERDA). Structurally, this program is made up of three parts: (1) documentation of the existing automotive gas turbine state-of-the-art; (2) conduction of an extensive component improvement program; and (3) utilization of the improvements in the design, and building of an Upgraded Engine capable of demonstrating program goals.

  2. Cell verification of parallel burnup calculation program MCBMPI based on MPI

    International Nuclear Information System (INIS)

    Yang Wankui; Liu Yaoguang; Ma Jimin; Wang Guanbo; Yang Xin; She Ding

    2014-01-01

    The parallel burnup calculation program MCBMPI was developed. The program was modularized. The parallel MCNP5 program MCNP5MPI was employed as neutron transport calculation module. And a composite of three solution methods was used to solve burnup equation, i.e. matrix exponential technique, TTA analytical solution, and Gauss Seidel iteration. MPI parallel zone decomposition strategy was concluded in the program. The program system only consists of MCNP5MPI and burnup subroutine. The latter achieves three main functions, i.e. zone decomposition, nuclide transferring and decaying, and data exchanging with MCNP5MPI. Also, the program was verified with the pressurized water reactor (PWR) cell burnup benchmark. The results show that it,s capable to apply the program to burnup calculation of multiple zones, and the computation efficiency could be significantly improved with the development of computer hardware. (authors)

  3. Programmed Necrosis: A Prominent Mechanism of Cell Death following Neonatal Brain Injury

    Directory of Open Access Journals (Sweden)

    Raul Chavez-Valdez

    2012-01-01

    Full Text Available Despite the introduction of therapeutic hypothermia, neonatal hypoxic ischemic (HI brain injury remains a common cause of developmental disability. Development of rational adjuvant therapies to hypothermia requires understanding of the pathways of cell death and survival modulated by HI. The conceptualization of the apoptosis-necrosis “continuum” in neonatal brain injury predicts mechanistic interactions between cell death and hydrid forms of cell death such as programmed or regulated necrosis. Many of the components of the signaling pathway regulating programmed necrosis have been studied previously in models of neonatal HI. In some of these investigations, they participate as part of the apoptotic pathways demonstrating clear overlap of programmed death pathways. Receptor interacting protein (RIP-1 is at the crossroads between types of cellular death and survival and RIP-1 kinase activity triggers formation of the necrosome (in complex with RIP-3 leading to programmed necrosis. Neuroprotection afforded by the blockade of RIP-1 kinase following neonatal HI suggests a role for programmed necrosis in the HI injury to the developing brain. Here, we briefly review the state of the knowledge about the mechanisms behind programmed necrosis in neonatal brain injury recognizing that a significant proportion of these data derive from experiments in cultured cell and some from in vivo adult animal models. There are still more questions than answers, yet the fascinating new perspectives provided by the understanding of programmed necrosis in the developing brain may lay the foundation for new therapies for neonatal HI.

  4. Declarative Parallel Programming in Spreadsheet End-User Development

    DEFF Research Database (Denmark)

    Biermann, Florian

    2016-01-01

    Spreadsheets are first-order functional languages and are widely used in research and industry as a tool to conveniently perform all kinds of computations. Because cells on a spreadsheet are immutable, there are possibilities for implicit parallelization of spreadsheet computations. In this liter...... can directly apply results from functional array programming to a spreadsheet model of computations.......Spreadsheets are first-order functional languages and are widely used in research and industry as a tool to conveniently perform all kinds of computations. Because cells on a spreadsheet are immutable, there are possibilities for implicit parallelization of spreadsheet computations....... In this literature study, we provide an overview of the publications on spreadsheet end-user programming and declarative array programming to inform further research on parallel programming in spreadsheets. Our results show that there is a clear overlap between spreadsheet programming and array programming and we...

  5. Logical development of the cell ontology.

    Science.gov (United States)

    Meehan, Terrence F; Masci, Anna Maria; Abdulla, Amina; Cowell, Lindsay G; Blake, Judith A; Mungall, Christopher J; Diehl, Alexander D

    2011-01-05

    The Cell Ontology (CL) is an ontology for the representation of in vivo cell types. As biological ontologies such as the CL grow in complexity, they become increasingly difficult to use and maintain. By making the information in the ontology computable, we can use automated reasoners to detect errors and assist with classification. Here we report on the generation of computable definitions for the hematopoietic cell types in the CL. Computable definitions for over 340 CL classes have been created using a genus-differentia approach. These define cell types according to multiple axes of classification such as the protein complexes found on the surface of a cell type, the biological processes participated in by a cell type, or the phenotypic characteristics associated with a cell type. We employed automated reasoners to verify the ontology and to reveal mistakes in manual curation. The implementation of this process exposed areas in the ontology where new cell type classes were needed to accommodate species-specific expression of cellular markers. Our use of reasoners also inferred new relationships within the CL, and between the CL and the contributing ontologies. This restructured ontology can be used to identify immune cells by flow cytometry, supports sophisticated biological queries involving cells, and helps generate new hypotheses about cell function based on similarities to other cell types. Use of computable definitions enhances the development of the CL and supports the interoperability of OBO ontologies.

  6. Logical Development of the Cell Ontology

    Directory of Open Access Journals (Sweden)

    Blake Judith A

    2011-01-01

    Full Text Available Abstract Background The Cell Ontology (CL is an ontology for the representation of in vivo cell types. As biological ontologies such as the CL grow in complexity, they become increasingly difficult to use and maintain. By making the information in the ontology computable, we can use automated reasoners to detect errors and assist with classification. Here we report on the generation of computable definitions for the hematopoietic cell types in the CL. Results Computable definitions for over 340 CL classes have been created using a genus-differentia approach. These define cell types according to multiple axes of classification such as the protein complexes found on the surface of a cell type, the biological processes participated in by a cell type, or the phenotypic characteristics associated with a cell type. We employed automated reasoners to verify the ontology and to reveal mistakes in manual curation. The implementation of this process exposed areas in the ontology where new cell type classes were needed to accommodate species-specific expression of cellular markers. Our use of reasoners also inferred new relationships within the CL, and between the CL and the contributing ontologies. This restructured ontology can be used to identify immune cells by flow cytometry, supports sophisticated biological queries involving cells, and helps generate new hypotheses about cell function based on similarities to other cell types. Conclusion Use of computable definitions enhances the development of the CL and supports the interoperability of OBO ontologies.

  7. Development of induction cells at CAEP

    International Nuclear Information System (INIS)

    Wang Huacen; Zhang Kaizhi; Cheng Nian'an; Zhang Wenwei; Lai Qinggui; Wen Long; Zhang Linwen; Deng Jianjun; Ding Bonan

    2002-01-01

    The effects to develop induction cells for induction linac and radiography at CAEP are introduced and reviewed in this paper. During the past two decades, several kinds of cells have been designed and tested, and some of them have been used for construction of induction linac, such as Dragon-1 and 12 MeV, and a Synthetic Test Stand (STS) for comprehensive linac technology study. The structure, test results and performance in the induction linac of these cells are given

  8. Hypertranscription in development, stem cells, and regeneration

    Science.gov (United States)

    Percharde, Michelle; Bulut-Karslioglu, Aydan; Ramalho-Santos, Miguel

    2016-01-01

    SUMMARY Cells can globally up-regulate their transcriptome during specific transitions, a phenomenon called hypertranscription. Evidence for hypertranscription dates back over 70 years, but it has gone largely ignored in the genomics era until recently. We discuss data supporting the notion that hypertranscription is a unifying theme in embryonic development, stem cell biology, regeneration and cell competition. We review the history, methods for analysis, underlying mechanisms and biological significance of hypertranscription. PMID:27989554

  9. Space solar cell technology development - A perspective

    Science.gov (United States)

    Scott-Monck, J.

    1982-01-01

    The developmental history of photovoltaics is examined as a basis for predicting further advances to the year 2000. Transistor technology was the precursor of solar cell development. Terrestrial cells were modified for space through changes in geometry and size, as well as the use of Ag-Ti contacts and manufacture of a p-type base. The violet cell was produced for Comsat, and involved shallow junctions, new contacts, and an enhanced antireflection coating for better radiation tolerance. The driving force was the desire by private companies to reduce cost and weight for commercial satellite power supplies. Liquid phase epitaxial (LPE) GaAs cells are the latest advancement, having a 4 sq cm area and increased efficiency. GaAs cells are expected to be flight ready in the 1980s. Testing is still necessary to verify production techniques and the resistance to electron and photon damage. Research will continue in CVD cell technology, new panel technology, and ultrathin Si cells.

  10. US Department of Energy fuel cell program for transportation applications

    Science.gov (United States)

    Patil, Pandit G.

    1992-01-01

    Fuel cells of offer promise as the best future replacement for internal combustion engines in transportation applications. Fuel cells operate more efficiently than internal combustion engines, and are capable of running on non-petroleum fuels such as methanol, ethanol, natural gas or hydrogen. Fuel cells can also have a major impact on improving air quality. They virtually eliminate particulates, NO(x) and sulfur oxide emissions, and significantly reduce hydrocarbons and carbon monoxide. The U.S. Department of Energy program on fuel cells for transportation applications is structured to advance fuel cells technologies from the R&D phase, through engineering design and scale-tip, to demonstration in cars, trucks, buses and locomotives, in order to provide energy savings, fuel flexibility and air quality improvements. This paper describes the present status of the U.S. program.

  11. Extracellular matrix, cell skeletons, and embryonic development.

    Science.gov (United States)

    Hay, E D

    1989-09-01

    During embryonic development, the extracellular matrix (ECM) promotes the production of differentiated products by epithelial cells and the migration of mesenchymal cells, and probably also plays a role in epithelial-mesenchymal transformation. Here we examine the role of the cell skeleton (actin, microtubules, intermediate filaments) in mediating matrix effects on mesenchymal cell morphology, migration, and formation. The interaction of both epithelial cells and mesenchymal cells with ECM seems to involve the actin cortex, which is best developed in the base of the epithelial cell, where it attaches to underlying matrix via membrane-intercalated receptors. To interact with the matrix, the fibroblast has appropriate ECM receptors and an actin cortex around the whole cell. The actin cortex is absolutely required for assumption of bipolar shape, elongation, and movement through the matrix. Since the cortex seems to be anchored to the matrix, it is unlikely that it moves during cell migration. A new hypothesis states that the microtubule- and intermediate filament-rich endoplasm, containing the nucleus, moves past the actin cortex-receptor-matrix complex into the newly synthesized front end of the mesenchymal cell to effect forward movement. When epithelial cells transform into mesenchyme in the embryo, or when they are induced to do this in vitro, they switch from the keratin intermediate filament profile to one rich in vimentin, and the effect of cell matrix interaction on cell shape is profoundly altered. Vimentin-actin interactions with ECM may be a major factor in the ability of a cell to become mesenchymal.(ABSTRACT TRUNCATED AT 250 WORDS)

  12. Disease-Specific Care: Spine Surgery Program Development.

    Science.gov (United States)

    Koerner, Katie; Franker, Lauren; Douglas, Barbara; Medero, Edgardo; Bromeland, Jennifer

    2017-10-01

    Minimal literature exists describing the process for development of a Joint Commission comprehensive spine surgery program within a community hospital health system. Components of a comprehensive program include structured communication across care settings, preoperative education, quality outcomes tracking, and patient follow-up. Organizations obtaining disease-specific certification must have clear knowledge of the planning, time, and overall commitment, essential to developing a successful program. Health systems benefit from disease-specific certification because of their commitment to a higher standard of service. Certification standards establish a framework for organizational structure and management and provide institutions a competitive edge in the marketplace. A framework for the development of a spine surgery program is described to help guide organizations seeking disease-specific certification. In developing a comprehensive program, it is critical to define the program's mission and vision, identify key stakeholders, implement clinical practice guidelines, and evaluate program outcomes.

  13. Longitudinal Outcomes of an Institutionally Developed Nurse Residency Program.

    Science.gov (United States)

    Cline, Debbie; La Frentz, Kelly; Fellman, Bryan; Summers, Barbara; Brassil, Kelly

    Nurse residency programs are widely implemented to enhance integration of new graduate nurses entering the workforce. This article presents a retrospective analysis of 10 years of residency data from an internally developed residency program that used the Casey-Fink Graduate Nurse Experience Survey. Outcomes of this program were similar to those from studies using commercially available products, suggesting that an internally developed residency curricula may be equally beneficial to the development of new graduate nurses.

  14. The fuel cell; development and possibilities

    Energy Technology Data Exchange (ETDEWEB)

    Van Rijnsoever, J.W.M.

    Activities on fuel cells and fuel cell development in the USA and Japan are surveyed. Possibilities for large scale application are mentioned. Attention is given to efficiency and environmental aspects. There are no problems about hazardous emissions. Besides electric power some heat is generated, which is not always a disadvantage. In many cases both are useful products. (A.V.)

  15. [Program optimization for bovine somatic cells nuclear transfer].

    Science.gov (United States)

    Lei, Anmin; Ma, Xiaoling; Gao, Zhimin; Hu, Yongce; Sui, Jinqiang; Huang, Weiwei; Zan, Linsen; Dou, Zhongying

    2009-09-01

    To optimize program of bovine somatic nuclear transfer, we used two different enucleation procedures (by Spindle-view system & Hoechst 33342 staining), two different procedures to introduce donor nuclei (by ooplasm microinjection & electrofusion), and three different group electrofusion parameters (group 1: 1.9 kV/cm, 10 micros, two; group 2: 1.5 kV/cm, 25 micros, two; group 3: 0.6 kV/cm, 100 micros, one) to reconstruct bovine cloned embryos. The cleavation rates and blastocyst development rates of cloned embryos were used to assess the efficiency of different operational procedure. Finally, the best combination of operational procedure, that the spindle-viewer system was used for oocytes enucleating, and donor cell was electrofused into ooplasm by electrical pulse (1.9 kV/cm, 10 micros, two) to reconstruct bovine cloned embryos. Then the excellent blastocysts were transferred to fosters for producing cloned cattle 80 high-quality cloned blastocysts were transferred into 33 fosters, two cloned calves were produced. According to the results, the optimized program could be used to produce cloned cattle.

  16. Development of Cell Analysis Software for Cultivated Corneal Endothelial Cells.

    Science.gov (United States)

    Okumura, Naoki; Ishida, Naoya; Kakutani, Kazuya; Hongo, Akane; Hiwa, Satoru; Hiroyasu, Tomoyuki; Koizumi, Noriko

    2017-11-01

    To develop analysis software for cultured human corneal endothelial cells (HCECs). Software was designed to recognize cell borders and to provide parameters such as cell density, coefficient of variation, and polygonality of cultured HCECs based on phase contrast images. Cultured HCECs with high or low cell density were incubated with Ca-free and Mg-free phosphate-buffered saline for 10 minutes to reveal the cell borders and were then analyzed with software (n = 50). Phase contrast images showed that cell borders were not distinctly outlined, but these borders became more distinctly outlined after phosphate-buffered saline treatment and were recognized by cell analysis software. The cell density value provided by software was similar to that obtained using manual cell counting by an experienced researcher. Morphometric parameters, such as the coefficient of variation and polygonality, were also produced by software, and these values were significantly correlated with cell density (Pearson correlation coefficients -0.62 and 0.63, respectively). The software described here provides morphometric information from phase contrast images, and it enables subjective and noninvasive quality assessment for tissue engineering therapy of the corneal endothelium.

  17. Higher Education Leadership Graduate Program Development

    Science.gov (United States)

    Freeman, Sydney, Jr.; Chambers, Crystal Renée; Newton, Rochelle

    2016-01-01

    Graduate programs in higher education administration and leadership have sought to equip students with the knowledge, skills, and competencies for higher education leadership; that is, to prepare globally minded leaders who can navigate the internal and external demands of, and for, higher education. With the use of the Lattuca and Stark model of…

  18. Student Development in an Experiential Learning Program

    Science.gov (United States)

    Gilbert, Brandi L.; Banks, Julianna; Houser, John H. W.; Rhodes, Simon J.; Lees, N. Douglas

    2014-01-01

    This study is an outcomes assessment of an experiential learning program for undergraduate students interested in life and health sciences careers enrolled at a public urban research institution. The year-long research and professional experience internships were projected to improve learning outcomes in undergraduates. The study included an…

  19. Research and development program, fiscal year 1974

    Energy Technology Data Exchange (ETDEWEB)

    1972-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for Fiscal Year 1974 is conducted within the scope of the following categories: Effects of Radiation of Living Organisms; Molecular and Cellular Radiobiology; Land and Fresh Water Environmental Sciences; Radiological and Health Physics and Instrumentation; and Nuclear Medical Research. (ACR)

  20. Cell death in Pseudomonas aeruginosa biofilm development

    DEFF Research Database (Denmark)

    Webb, J.S.; Thompson, L.S.; James, S.

    2003-01-01

    Bacteria growing in biofilms often develop multicellular, three-dimensional structures known as microcolonies. Complex differentiation within biofilms of Pseudomonas aeruginosa occurs, leading to the creation of voids inside microcolonies and to the dispersal of cells from within these voids...

  1. THE PROGRAMED CELL DEATH REGULATORS OF ISOLATED MODEL SYSTEMS

    Directory of Open Access Journals (Sweden)

    D. V. Vatlitsov

    2016-06-01

    Full Text Available The technology evolution creates the prerequisites for the emergence of new informational concept and approaches to the formation of a fundamentally new principles of biological objects understanding. The aim was to study the activators of the programmed cell death in an isolated system model. Cell culture aging parameters were performed on flow cytometer. It had formed the theory that the changes in the concentrations of metal ions and increase their extracellular concentration had formed a negative gradient into the cells.regulation of cell death. It was shown that the metals ions concentrations.

  2. LG Solid Oxide Fuel Cell (SOFC) Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Haberman, Ben [LG Fuel Cell Systems Inc., North Canton, OH (United States); Martinez-Baca, Carlos [LG Fuel Cell Systems Inc., North Canton, OH (United States); Rush, Greg [LG Fuel Cell Systems Inc., North Canton, OH (United States)

    2013-05-31

    This report presents a summary of the work performed by LG Fuel Cell Systems Inc. during the project LG Solid Oxide Fuel Cell (SOFC) Model Development (DOE Award Number: DE-FE0000773) which commenced on October 1, 2009 and was completed on March 31, 2013. The aim of this project is for LG Fuel Cell Systems Inc. (formerly known as Rolls-Royce Fuel Cell Systems (US) Inc.) (LGFCS) to develop a multi-physics solid oxide fuel cell (SOFC) computer code (MPC) for performance calculations of the LGFCS fuel cell structure to support fuel cell product design and development. A summary of the initial stages of the project is provided which describes the MPC requirements that were developed and the selection of a candidate code, STAR-CCM+ (CD-adapco). This is followed by a detailed description of the subsequent work program including code enhancement and model verification and validation activities. Details of the code enhancements that were implemented to facilitate MPC SOFC simulations are provided along with a description of the models that were built using the MPC and validated against experimental data. The modeling work described in this report represents a level of calculation detail that has not been previously available within LGFCS.

  3. Development of Transition Programs for Adolescents with Serious Emotional Disturbances.

    Science.gov (United States)

    Bulen, Julia; Bullis, Michael

    This paper reports on an ongoing 3-year project which has worked with three school sites to identify program and staff needs and then develop a tailored intervention to improve program services for adolescent students with severe emotional disturbances (SED). Necessary characteristics of effective transition programs for this population are…

  4. Developing an Online Certification Program for Nutrition Education Assistants

    Science.gov (United States)

    Christofferson, Debra; Christensen, Nedra; LeBlanc, Heidi; Bunch, Megan

    2012-01-01

    Objective: To develop an online certification program for nutrition education paraprofessionals to increase knowledge and confidence and to overcome training barriers of programming time and travel expenses. Design: An online interactive certification course based on Supplemental Nutrition Assistance Program-Education and Expanded Food and…

  5. Development and Operation of a Voluntary Audit Program.

    Science.gov (United States)

    Murphy, Jerome R.

    This report describes a voluntary audit program implemented by the Educational Testing Service (ETS). The comprehensive audit program was developed to assure that all corporate programs adhere to the ETS Standards for Quality and Fairness. The standards address issues which relate to all ETS activities such as accountability, confidentiality of…

  6. Enhancing Agency through Leadership Development Programs for Faculty

    Science.gov (United States)

    Templeton, Lindsey; O'Meara, KerryAnn

    2018-01-01

    The ADVANCE Leadership Fellows Program at the University of Maryland is a yearlong professional development program for faculty aspiring to or recently engaged in leadership roles. Data shows an increase in participants' sense of agency to become academic leaders following the program. We use a comprehensive data set, including program…

  7. Developing Adult Education Programs for Probation and Parole.

    Science.gov (United States)

    Wimer, Maija

    This handbook, consisting of a program development model that is based on three programs for ex-offenders that were implemented in Texas in fiscal year 1983, is designed to assist adult educators in implementing adult education programs for persons on parole or probation. Discussed first are the purpose of the handbook, the individual sites of the…

  8. The Voice of Youth: Atmosphere in Positive Youth Development Program

    Science.gov (United States)

    Ward, Stefan; Parker, Melissa

    2013-01-01

    Background: Positive youth development (PYD) programs adhere to the notion that all children have strengths and assets to be promoted and nurtured rather than deficits that require "fixing." The study of PYD programs indicates three aspects which set them apart from other programs for youth: activities, goals, and atmosphere. Of these,…

  9. Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells

    Science.gov (United States)

    Yang, Lili; Baltimore, David

    2005-03-01

    A method to genetically program mouse hematopoietic stem cells to develop into functional CD8 or CD4 T cells of defined specificity in vivo is described. For this purpose, a bicistronic retroviral vector was engineered that efficiently delivers genes for both and chains of T cell receptor (TCR) to hematopoietic stem cells. When modified cell populations were used to reconstruct the hematopoietic lineages of recipient mice, significant percentages of antigen-specific CD8 or CD4 T cells were observed. These cells expressed normal surface markers and responded to peptide antigen stimulation by proliferation and cytokine production. Moreover, they could mature into memory cells after peptide stimulation. Using TCRs specific for a model tumor antigen, we found that the recipient mice were able to partially resist a challenge with tumor cells carrying the antigen. By combining cells modified with CD8- and CD4-specific TCRs, and boosting with dendritic cells pulsed with cognate peptides, complete suppression of tumor could be achieved and even tumors that had become established would regress and be eliminated after dendritic cell/peptide immunization. This methodology of "instructive immunotherapy" could be developed for controlling the growth of human tumors and attacking established pathogens.

  10. AECL's research and development program in environmental science and technology

    International Nuclear Information System (INIS)

    Cornett, R.J.

    1998-07-01

    AECL's radiological research and development (R and D) program encompasses work on sources of radiation exposure, radionuclide transport through the environment and potential impacts on biota and on human health. The application of the radiation protection knowledge and technology developed in this program provides cradle-to-grave management for CANDU and related nuclear technologies. This document provides an overview of the Environmental Science and Technology (ES and T) program which is one of the technical areas of R and D within the radiological R and D program. The ES and T program uses science from three main areas: radiochemistry, mathematical modelling and environmental assessment. In addition to providing an overview of the program, this summary also gives specific examples of recent technical work in each of the three areas. These technical examples illustrate the applied nature of the ES and T program and the close coupling of the program to CANDU customer requirements. (author)

  11. Recent developments in small molecule therapies for renal cell carcinoma.

    Science.gov (United States)

    Song, Minsoo

    2017-12-15

    Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and is known to be the 10th most common type of cancer in the world. Most of the currently available RCC drugs are tyrosine kinase inhibitors (TKIs). However, combination therapies of TKIs and immune checkpoint inhibitors such as programmed cell death protein 1 (PD-1) and programmed cell death protein 1 ligand 1 (PD-L1) inhibitors are the focus of most of the final stage clinical trials. Meanwhile, other small molecule therapies for RCC that target indoleamine-2,3-dioxygenase (IDO1), glutaminase, C-X-C chemokine receptor 4 (CXCR4), and transglutaminase 2 (TG2) are emerging as the next generation of therapeutics. In this review, these three major streams for the development of small molecule drugs for RCC are described. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  12. Biofuels Feedstock Development Program annual progress report for 1991

    Energy Technology Data Exchange (ETDEWEB)

    Wright, L.L.; Cushman, J.H.; Ehrenshaft, A.R.; McLaughlin, S.B.; McNabb, W.A.; Ranney, J.W.; Tuskan, G.A.; Turhollow, A.F.

    1992-12-01

    This report provides an overview of the ongoing research funded in 1991 by the Department of Energy`s Biofuels Feedstock Development Program (BFDP). The BFDP is managed by the Environmental Sciences Division of the Oak Ridge National Laboratory and encompasses the work formerly funded by the Short Rotation Woody Crops Program and the Herbaceous Energy Crops Program. The combined program includes crop development research on both woody and herbaceous energy crop species, cross-cutting energy and environmental analysis and integration, and information management activities. Brief summaries of 26 different program activities are included in the report.

  13. Biofuels Feedstock Development Program annual progress report for 1991

    Energy Technology Data Exchange (ETDEWEB)

    Wright, L.L.; Cushman, J.H.; Ehrenshaft, A.R.; McLaughlin, S.B.; McNabb, W.A.; Ranney, J.W.; Tuskan, G.A.; Turhollow, A.F.

    1992-12-01

    This report provides an overview of the ongoing research funded in 1991 by the Department of Energy's Biofuels Feedstock Development Program (BFDP). The BFDP is managed by the Environmental Sciences Division of the Oak Ridge National Laboratory and encompasses the work formerly funded by the Short Rotation Woody Crops Program and the Herbaceous Energy Crops Program. The combined program includes crop development research on both woody and herbaceous energy crop species, cross-cutting energy and environmental analysis and integration, and information management activities. Brief summaries of 26 different program activities are included in the report.

  14. The US Army Foreign Comparative Test fuel cell program

    Science.gov (United States)

    Bostic, Elizabeth; Sifer, Nicholas; Bolton, Christopher; Ritter, Uli; Dubois, Terry

    The US Army RDECOM initiated a Foreign Comparative Test (FCT) Program to acquire lightweight, high-energy dense fuel cell systems from across the globe for evaluation as portable power sources in military applications. Five foreign companies, including NovArs, Smart Fuel Cell, Intelligent Energy, Ballard Power Systems, and Hydrogenics, Inc., were awarded competitive contracts under the RDECOM effort. This paper will report on the status of the program as well as the experimental results obtained from one of the units. The US Army has interests in evaluating and deploying a variety of fuel cell systems, where these systems show added value when compared to current power sources in use. For low-power applications, fuel cells utilizing high-energy dense fuels offer significant weight savings over current battery technologies. This helps reduce the load a solider must carry for longer missions. For high-power applications, the low operating signatures (acoustic and thermal) of fuel cell systems make them ideal power generators in stealth operations. Recent testing has been completed on the Smart Fuel Cell A25 system that was procured through the FCT program. The "A-25" is a direct methanol fuel cell hybrid and was evaluated as a potential candidate for soldier and sensor power applications.

  15. Development and Prospect of Nanoarchitectured Solar Cells

    Directory of Open Access Journals (Sweden)

    Bo Zhang

    2015-01-01

    Full Text Available This paper gives an overview of the development and prospect of nanotechnologies utilized in the solar cell applications. Even though it is not clearly pointed out, nanostructures indeed have been used in the fabrication of conventional solar cells for a long time. However, in those circumstances, only very limited benefits of nanostructures have been used to improve cell performance. During the last decade, the development of the photovoltaic device theory and nanofabrication technology enables studies of more complex nanostructured solar cells with higher conversion efficiency and lower production cost. The fundamental principles and important features of these advanced solar cell designs are systematically reviewed and summarized in this paper, with a focus on the function and role of nanostructures and the key factors affecting device performance. Among various nanostructures, special attention is given to those relying on quantum effect.

  16. An Android Research and Development Program.

    Science.gov (United States)

    1983-03-01

    areas discussed were robot arms, robot hands, and robot locomotion systems, without reference to a specific model. He summarized the control issues...school to do this. AFAMRL. The Air Force Aerospace Medical Research Laboratory and its Modeling and Analysis Branch had a program in areas of bionics ...Manipulators. He worked most of 1979 for Unimation prior to coming on active duty (Air Force). McGhee, R. B. "Robot Locomotion with Active Terrain

  17. Effective Strategic Programming for Java Developers

    OpenAIRE

    Balland, Emilie; Moreau, Pierre-Etienne; Reilles, Antoine

    2014-01-01

    International audience; In object programming languages, the Visitor design pattern allows separation of algorithms and data-structures. When applying this pattern to tree-like structures, programmers are always confronted with the difficulty of making their code evolve. One reason is that the code implementing the algorithm is interwound with the code implementing the traversal inside the Visitor. When implementing algorithms such as data analyses or transformations, encoding the traversal d...

  18. Laboratory Directed Research and Development Program

    International Nuclear Information System (INIS)

    1994-02-01

    This report is compiled from annual reports submitted by principal investigators following the close of fiscal year 1993. This report describes the projects supported and summarizes their accomplishments. The program advances the Laboratory's core competencies, foundations, scientific capability, and permits exploration of exciting new opportunities. Reports are given from the following divisions: Accelerator and Fusion Research, Chemical Sciences, Earth Sciences, Energy and Environment, Engineering, Environment -- Health and Safety, Information and Computing Sciences, Life Sciences, Materials Sciences, Nuclear Science, Physics, and Structural Biology

  19. 78 FR 49374 - Rural Development Voucher Program

    Science.gov (United States)

    2013-08-14

    ...-NEW. Type of Request: New collection. Abstract: Information is completed by tenants, voucher holders..., Rural Development Housing Assistance Payments contract, and the voucher itself. The collection of... ``Rural Development Assistance Payment Contract,'' ``Voucher,'' ``Voucher assistance,'' ``Voucher holder...

  20. PDQ-8 reference manual (LWBR development program)

    Energy Technology Data Exchange (ETDEWEB)

    Pfiefer, C J; Spitz, C J

    1978-05-01

    The PDQ-8 program is designed to solve the neutron diffusion, depletion problem in one, two, or three dimensions on the CDC-6600 and CDC-7600 computers. The three dimensional spatial calculation may be either explicit or discontinuous trial function synthesis. Up to five lethargy groups are permitted. The fast group treatment may be simplified P(3), and the thermal neutrons may be represented by a single group or a pair of overlapping groups. Adjoint, fixed source, one iteration, additive fixed source, eigenvalue, and boundary value calculations may be performed. The HARMONY system is used for cross section variation and generalized depletion chain solutions. The depletion is a combination gross block depletion for all nuclides as well as a fine block depletion for a specified subset of the nuclides. The geometries available include rectangular, cylindrical, spherical, hexagonal, and a very general quadrilateral geometry with diagonal interfaces. All geometries allow variable mesh in all dimensions. Various control searches as well as temperature and xenon feedbacks are provided. The synthesis spatial solution time is dependent on the number of trial functions used and the number of gross blocks. The PDQ-8 program is used at Bettis on a production basis for solving diffusion--depletion problems. The report describes the various features of the program and then separately describes the input required to utilize these features.

  1. Stomach development, stem cells and disease.

    Science.gov (United States)

    Kim, Tae-Hee; Shivdasani, Ramesh A

    2016-02-15

    The stomach, an organ derived from foregut endoderm, secretes acid and enzymes and plays a key role in digestion. During development, mesenchymal-epithelial interactions drive stomach specification, patterning, differentiation and growth through selected signaling pathways and transcription factors. After birth, the gastric epithelium is maintained by the activity of stem cells. Developmental signals are aberrantly activated and stem cell functions are disrupted in gastric cancer and other disorders. Therefore, a better understanding of stomach development and stem cells can inform approaches to treating these conditions. This Review highlights the molecular mechanisms of stomach development and discusses recent findings regarding stomach stem cells and organoid cultures, and their roles in investigating disease mechanisms. © 2016. Published by The Company of Biologists Ltd.

  2. Prolonged Expression of Puma in Cholinergic Amacrine Cells During the Development of Rat Retina

    Science.gov (United States)

    Kosaka, Jun; Mori, Tetsuji; Yamada, Hisao

    2012-01-01

    During development of the nervous system, large numbers of neurons are overproduced and then eliminated by programmed cell death. Puma is a BH3-only protein that is reported to be involved in the initiation of developmental programmed cell death in rodent retinal neurons. The expression and cellular localization of Puma in retinal tissues during development are not, however, well known. Here the authors report the expression pattern of Puma during retinal development in the rat. During the period of programmed cell death in the retina, Puma was expressed in some members of each retinal neuron, including retinal ganglion cells, amacrine cells, bipolar cells, horizontal cells, and photoreceptor cells. Although the developmental programmed cell death of cholinergic amacrine cells is known to be independent of Puma, this protein was expressed in almost all their dendrites and somata of cholinergic amacrine cells at postnatal age 2 to 3 weeks, and it continued to be detected in cholinergic dendrites in the inner plexiform layer for up to 8 weeks after birth. These results suggest that Puma has some significant roles in retinal neurons after eye opening, especially that of cholinergic amacrine cells, in addition to programmed cell death of retinal neurons before eye opening. PMID:22736709

  3. Cell fate regulation in early mammalian development

    International Nuclear Information System (INIS)

    Oron, Efrat; Ivanova, Natalia

    2012-01-01

    Preimplantation development in mammals encompasses a period from fertilization to implantation and results in formation of a blastocyst composed of three distinct cell lineages: epiblast, trophectoderm and primitive endoderm. The epiblast gives rise to the organism, while the trophectoderm and the primitive endoderm contribute to extraembryonic tissues that support embryo development after implantation. In many vertebrates, such as frog or fish, maternally supplied lineage determinants are partitioned within the egg. Cell cleavage that follows fertilization results in polarization of these factors between the individual blastomeres, which become restricted in their developmental fate. In contrast, the mouse oocyte and zygote lack clear polarity and, until the eight-cell stage, individual blastomeres retain the potential to form all lineages. How are cell lineages specified in the absence of a maternally supplied blueprint? This is a fundamental question in the field of developmental biology. The answer to this question lies in understanding the cell–cell interactions and gene networks involved in embryonic development prior to implantation and using this knowledge to create testable models of the developmental processes that govern cell fates. We provide an overview of classic and contemporary models of early lineage development in the mouse and discuss the emerging body of work that highlights similarities and differences between blastocyst development in the mouse and other mammalian species. (paper)

  4. Anhydrobiosis and programmed cell death in plants: Commonalities and Differences

    Directory of Open Access Journals (Sweden)

    Samer Singh

    2015-05-01

    Full Text Available Anhydrobiosis is an adaptive strategy of certain organisms or specialised propagules to survive in the absence of water while programmed cell death (PCD is a finely tuned cellular process of the selective elimination of targeted cell during developmental programme and perturbed biotic and abiotic conditions. Particularly during water stress both the strategies serve single purpose i.e., survival indicating PCD may also function as an adaptive process under certain conditions. During stress conditions PCD cause targeted cells death in order to keep the homeostatic balance required for the organism survival, whereas anhydrobiosis suspends cellular metabolic functions mimicking a state similar to death until reestablishment of the favourable conditions. Anhydrobiosis is commonly observed among organisms that have ability to revive their metabolism on rehydration after removal of all or almost all cellular water without damage. This feature is widely represented in terrestrial cyanobacteria and bryophytes where it is very common in both vegetative and reproductive stages of life-cycle. In the course of evolution, with the development of advanced vascular system in higher plants, anhydrobiosis was gradually lost from the vegetative phase of life-cycle. Though it is retained in resurrection plants that primarily belong to thallophytes and a small group of vascular angiosperm, it can be mostly found restricted in orthodox seeds of higher plants. On the contrary, PCD is a common process in all eukaryotes from unicellular to multicellular organisms including higher plants and mammals. In this review we discuss physiological and biochemical commonalities and differences between anhydrobiosis and PCD.

  5. Comparative analysis of programmed cell death pathways in filamentous fungi

    Directory of Open Access Journals (Sweden)

    Wortman Jennifer R

    2005-12-01

    Full Text Available Abstract Background Fungi can undergo autophagic- or apoptotic-type programmed cell death (PCD on exposure to antifungal agents, developmental signals, and stress factors. Filamentous fungi can also exhibit a form of cell death called heterokaryon incompatibility (HI triggered by fusion between two genetically incompatible individuals. With the availability of recently sequenced genomes of Aspergillus fumigatus and several related species, we were able to define putative components of fungi-specific death pathways and the ancestral core apoptotic machinery shared by all fungi and metazoa. Results Phylogenetic profiling of HI-associated proteins from four Aspergilli and seven other fungal species revealed lineage-specific protein families, orphan genes, and core genes conserved across all fungi and metazoa. The Aspergilli-specific domain architectures include NACHT family NTPases, which may function as key integrators of stress and nutrient availability signals. They are often found fused to putative effector domains such as Pfs, SesB/LipA, and a newly identified domain, HET-s/LopB. Many putative HI inducers and mediators are specific to filamentous fungi and not found in unicellular yeasts. In addition to their role in HI, several of them appear to be involved in regulation of cell cycle, development and sexual differentiation. Finally, the Aspergilli possess many putative downstream components of the mammalian apoptotic machinery including several proteins not found in the model yeast, Saccharomyces cerevisiae. Conclusion Our analysis identified more than 100 putative PCD associated genes in the Aspergilli, which may help expand the range of currently available treatments for aspergillosis and other invasive fungal diseases. The list includes species-specific protein families as well as conserved core components of the ancestral PCD machinery shared by fungi and metazoa.

  6. Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation.

    Science.gov (United States)

    Le Rolle, Anne-France; Chiu, Thang K; Zeng, Zhaoshi; Shia, Jinru; Weiser, Martin R; Paty, Philip B; Chiu, Vi K

    2016-01-19

    Colorectal cancer is the third most frequently diagnosed cancer worldwide. Prevention of colorectal cancer initiation represents the most effective overall strategy to reduce its associated morbidity and mortality. Activating KRAS mutation (KRASmut) is the most prevalent oncogenic driver in colorectal cancer development, and KRASmut inhibition represents an unmet clinical need. We apply a systems-level approach to study the impact of KRASmut on stem cell signaling during human colon cancer initiation by performing gene set enrichment analysis on gene expression from human colon tissues. We find that KRASmut imposes the embryonic stem cell-like program during human colon cancer initiation from colon adenoma to stage I carcinoma. Expression of miR145, an embryonic SC program inhibitor, promotes cell lineage differentiation marker expression in KRASmut colon cancer cells and significantly suppresses their tumorigenicity. Our data support an in vivo plasticity model of human colon cancer initiation that merges the intrinsic stem cell properties of aberrant colon stem cells with the embryonic stem cell-like program induced by KRASmut to optimize malignant transformation. Inhibition of the embryonic SC-like program in KRASmut colon cancer cells reveals a novel therapeutic strategy to programmatically inhibit KRASmut tumors and prevent colon cancer.

  7. Overview of PNGV Battery Development and Test Programs

    Energy Technology Data Exchange (ETDEWEB)

    Motloch, Chester George; Murphy, Timothy Collins; Sutula, Raymond; Miller, Ted J.

    2002-02-01

    Affordable, safe, long-lasting, high-power batteries are requisites for successful commercialization of hybrid electric vehicles. The U.S. Department of Energy’s Office of Advance Automotive Technologies and the Partnership for a New Generation of Vehicles are funding research and development programs to address each of these issues. An overview of these areas is presented along with a summary of battery development and test programs, as well as recent performance data from several of these programs.

  8. Automation of program model developing for complex structure control objects

    International Nuclear Information System (INIS)

    Ivanov, A.P.; Sizova, T.B.; Mikhejkina, N.D.; Sankovskij, G.A.; Tyufyagin, A.N.

    1991-01-01

    A brief description of software for automated developing the models of integrating modular programming system, program module generator and program module library providing thermal-hydraulic calcualtion of process dynamics in power unit equipment components and on-line control system operation simulation is given. Technical recommendations for model development are based on experience in creation of concrete models of NPP power units. 8 refs., 1 tab., 4 figs

  9. Transfer of Training in an Academic Leadership Development Program for Program Coordinators

    Science.gov (United States)

    Ladyshewsky, Richard K.; Flavell, Helen

    2012-01-01

    The higher education sector has increasingly begun to pay more attention to academic leadership. This qualitative study explores how such an investment in a 20-week leadership development program influenced the behaviour of 10 academic staff in the role of program coordinator 6 to 12 months following participation in the program. Otherwise known…

  10. Developing an integrated dam safety program

    International Nuclear Information System (INIS)

    Nielsen, N. M.; Lampa, J.

    1996-01-01

    An effort has been made to demonstrate that dam safety is an integral part of asset management which, when properly done, ensures that all objectives relating to safety and compliance, profitability, stakeholders' expectations and customer satisfaction, are achieved. The means to achieving this integration of the dam safety program and the level of effort required for each core function have been identified using the risk management approach to pinpoint vulnerabilities, and subsequently to focus priorities. The process is considered appropriate for any combination of numbers, sizes and uses of dams, and is designed to prevent exposure to unacceptable risks. 5 refs., 1 tab

  11. Center Independent Research & Developments: JPL IRAD Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Innovative projects are sought in the areas of basic research, fundamental research, applied research, development and systems and other concept formulation studies....

  12. Developments in the electron gun simulation program, EGUN

    International Nuclear Information System (INIS)

    Herrmannsfeldt, W.B.

    1994-11-01

    This paper discusses the developments in the electron gun simulation programs that are based on EGUN with its derivatives and supporting programs. Much of the code development has been inspired by technology changes in computer hardware; the implications of this evolution on EGN2 are discussed. Some examples and a review of the capabilities of the EGUN family are described

  13. Talent Development Middle Grades Program. What Works Clearinghouse Intervention Report

    Science.gov (United States)

    What Works Clearinghouse, 2013

    2013-01-01

    The "Talent Development Middle Grades Program" is a comprehensive reform model that transforms the structure and curriculum of large urban middle schools with the aim of improving student achievement and raising teacher and student expectations. Key features of the "Talent Development Middle Grades Program" include small…

  14. Mathematics Teachers' Professional Development Program--Needs and Expectations

    Science.gov (United States)

    Levi-Keren, Michal; Patkin, Dorit

    2016-01-01

    This paper presents the major findings and recommendations from a formative evaluation of the first of a 2-year in-service training program. This program was designed for the professional development of math teachers. It was developed following an educational reform, which was meant to enhance the teachers' ability to generate changes in their…

  15. Development of an Actuarial Science Program at Salisbury University

    Science.gov (United States)

    Wainwright, Barbara A.

    2014-01-01

    This paper focuses on the development of an actuarial science track for the mathematics major at Salisbury University (SU). A timeline from the initial investigation into such a program through the proposal and approval processes is shared for those who might be interested in developing a new actuarial program. It is wise to start small and take…

  16. Extension Youth Educators' Technology Use in Youth Development Programming

    Science.gov (United States)

    McClure, Carli; Buquoi, Brittany; Kotrlik, Joe W.; Machtmes, Krisanna; Bunch, J. C.

    2014-01-01

    The purpose of this descriptive-correlational study was to determine the use of technology in youth programming by Extension youth development educators in Louisiana, Mississippi, and Tennessee. Data were collected via e-mail and a SurveyMonkey© questionnaire. Extension educators are using some technology in youth development programming. More…

  17. Interplay between autophagy and programmed cell death in mammalian neural stem cells

    Directory of Open Access Journals (Sweden)

    Kyung Min Chung

    2013-08-01

    Full Text Available Mammalian neural stem cells (NSCs are of particular interestbecause of their role in brain development and function. Recentfindings suggest the intimate involvement of programmed celldeath (PCD in the turnover of NSCs. However, the underlyingmechanisms of PCD are largely unknown. Although apoptosis isthe best-defined form of PCD, accumulating evidence hasrevealed a wide spectrum of PCD encompassing apoptosis,autophagic cell death (ACD and necrosis. This mini-reviewaims to illustrate a unique regulation of PCD in NSCs. Theresults of our recent studies on autophagic death of adulthippocampal neural stem (HCN cells are also discussed. HCNcell death following insulin withdrawal clearly provides areliable model that can be used to analyze the molecularmechanisms of ACD in the larger context of PCD. Moreresearch efforts are needed to increase our understanding of themolecular basis of NSC turnover under degenerating conditions,such as aging, stress and neurological diseases. Efforts aimed atprotecting and harnessing endogenous NSCs will offer novelopportunities for the development of new therapeutic strategiesfor neuropathologies. [BMB Reports 2013; 46(8: 383-390

  18. DOD Residential Proton Exchange Membrane (PEM) Fuel Cell Demonstration Program. Volume 1. Summary of the Fiscal Year 2001 Program

    National Research Council Canada - National Science Library

    White, Melissa K; Holcomb, Franklin H; Josefik, Nicholas M; Lux, Scott M; Binder, Michael J

    2004-01-01

    ...) fuel cells at military facilities. The objective of the program was to assess PEM fuel cells in supporting sustainability in military installations, increasing efficiency in installation, operation, and maintenance of fuel cells...

  19. Developing Education Programs or Population Awareness.

    Science.gov (United States)

    Viederman, Stephen

    Speakers on population matters often refer to the population explosion with an air of crisis. It is questionable that images of doomsday are defensible for us in our role as educators. The goals of population education are to develop an understanding of the impacts of population characteristics on national development, as well as their impact on…

  20. Practical Leader Development Program Using Emotional Intelligence

    DEFF Research Database (Denmark)

    Barfod, Jakob Rømer; Bakkegaard, Bjarne

    2017-01-01

    The Danish Army has more than ten years of experience working with developing emotional intelligence in the Royal Danish Army Officers’ Academy (RDAOA), and the Academy has developed military leaders who have benefitted from emotional intelligence training. Today many of the military leaders...

  1. Development of mucilage cells of Araucaria angustifolia (Araucariaceae).

    Science.gov (United States)

    Mastroberti, A A; Mariath, J E de Araujo

    2008-01-01

    The roles of mucilage cells were investigated through morphological and cytological analysis during leaf development in young Araucaria angustifolia plants. Differentiation began in leaf primordia in the shoot apex, when the young cells underwent a greater increase in volume in comparison with other mesophyll cells. The mucilage polysaccharides were synthesized by dictyosomes, from where they were taken by large vesicles and released into a cavity formed by detachment of the tonoplast, which was separated from the cytoplasm. At the end of differentiation, the cell was completely filled with mucilage, a gel consisting of a denser reticular structure surrounding less dense regions. The nucleus and cytoplasm were degenerated in mature cells. The A. angustifolia mucilage cells presented some cytological resemblances to the mucilage cells of members of some dicotyledonous families; however, differences in the dictyosomes and the secretion route were observed. Translocation and water storage of solutes was suggested by the use of the hydroxy pyrenetrisulfonic acid tri-sodium salt apoplastic tracer. The tonoplast detachment, dechromatinization, nuclear condensation, and general degeneration of the membrane systems observed during maturity indicated a programmed cell death process, one not yet described for angiosperm mucilage cells.

  2. An integrated programming and development environment for adiabatic quantum optimization

    International Nuclear Information System (INIS)

    S Humble, T; J McCaskey, A; S Bennink, R; J Billings, J; F D'Azevedo, E; D Sullivan, B; F Klymko, C; Seddiqi, H

    2014-01-01

    Adiabatic quantum computing is a promising route to the computational power afforded by quantum information processing. The recent availability of adiabatic hardware has raised challenging questions about how to evaluate adiabatic quantum optimization (AQO) programs. Processor behavior depends on multiple steps to synthesize an adiabatic quantum program, which are each highly tunable. We present an integrated programming and development environment for AQO called Jade Adiabatic Development Environment (JADE) that provides control over all the steps taken during program synthesis. JADE captures the workflow needed to rigorously specify the AQO algorithm while allowing a variety of problem types, programming techniques, and processor configurations. We have also integrated JADE with a quantum simulation engine that enables program profiling using numerical calculation. The computational engine supports plug-ins for simulation methodologies tailored to various metrics and computing resources. We present the design, integration, and deployment of JADE and discuss its potential use for benchmarking AQO programs by the quantum computer science community. (paper)

  3. A Leadership Education and Development Program for Clinical Nurses.

    Science.gov (United States)

    Fitzpatrick, Joyce J; Modic, Mary Beth; Van Dyk, Jennifer; Hancock, K Kelly

    2016-11-01

    The Leadership Education and Development (LEAD) Program was designed to transform care at the bedside by empowering clinical nurses as leaders. The heart of LEAD was enhancing communication skills of clinical nurses with clinical colleagues and, most importantly, patients and families. Key concepts of leadership/management were included: personal awareness, personal leadership skills/abilities, leading change, leading others individually and in teams, enhancing the patient/provider experience, and the leadership role in outcomes management. A quantitative, longitudinal, survey design was used with 2 cohorts. The program consisted of six 4-hour sessions for 3 to 6 months. Leadership practices were measured before program implementation, at the end of the program, and 3 months after program completion. There were significant increases in leadership practices sustained 3 months after program completion. A range of other outcome measures was included. There is a need for additional leadership development programs for clinical nurses.

  4. Programmed subcellular release to study the dynamics of cell detachment

    Science.gov (United States)

    Wildt, Bridget

    Cell detachment is central to a broad range of physio-pathological changes however there are no quantitative methods to study this process. Here we report programmed subcellular release, a method for spatially and temporally controlled cellular detachment and present the first quantitative results of the detachment dynamics of 3T3 fibroblasts at the subcellular level. Programmed subcellular release is an in vitro technique designed to trigger the detachment of distinct parts of a single cell from a patterned substrate with both spatial and temporal control. Subcellular release is achieved by plating cells on an array of patterned gold electrodes created by standard microfabrication techniques. The electrodes are biochemically functionalized with an adhesion-promoting RGD peptide sequence that is attached to the gold electrode via a thiol linkage. Each electrode is electrically isolated so that a subcellular section of a single cell spanning multiple electrodes can be released independently. Upon application of a voltage pulse to a single electrode, RGD-thiol molecules on an individual electrode undergo rapid electrochemical desorption that leads to subsequent cell contraction. The dynamics of cell contraction are found to have characteristic induction and contraction times. This thesis presents the first molecular inhibition studies conducted using programmed subcellular release verifying that this technique can be used to study complex signaling pathways critical to cell motility. Molecular level dynamics of focal adhesion proteins and actin stress fibers provide some insight into the complexities associated with triggered cell detachment. In addition to subcellular release, the programmed release of alkanethiols provides a tool for to study the spatially and temporally controlled release of small molecules or particles from individually addressable gold electrodes. Here we report on experiments which determine the dynamics of programmed release using fluorophore

  5. Strategic planning for molten carbonate fuel cell development and commercialization

    Science.gov (United States)

    Williams, M. C.; Mayfield, M. J.

    The molten carbonate fuel cell (MCFC), a high-temperature fuel cell, is a promising energy conversion product for generating electricity. Natural gas availability appears to play a key role in MCFC commercialization; natural gas MCFC and Integrated Gasification MCFC (IGMCFC) are emerging power generation options that are responsive to requirements of Clean Air Act amendments and to guidance in National Energy Strategy. Goal of DOE IGMCFC program is to demonstrate the commercial readiness of this technology by the year 2010. DOE MCFC development objectives and planned activities are outlined.

  6. Center Independent Research & Developments: JSC IRAD Program

    Data.gov (United States)

    National Aeronautics and Space Administration — JSC provides and applies its preeminent capabilities in science and technology to develop, operate, and integrate human exploration missions.  The center...

  7. Empirical Studies of Agile Software Development to Learn Programming Skills

    Directory of Open Access Journals (Sweden)

    Yasuyo Kofune

    2014-06-01

    Full Text Available This paper presents a programming education support method based on Agile Development that encourages and builds on communication between students. Through mutual discussion, students using our approach transform their ideas into software and cooperate to write a program. The students complete the software through repetition and programming. Before completing the software program, the students learn to solve problems by working together. The students are encouraged to think and share ideas, and gain experience writing software. With this approach, students not only learn how to write programs, but also increase their logical thinking, problem-solving, and communication skills.

  8. Developing the strategic plan for pollution prevention in defense programs

    International Nuclear Information System (INIS)

    Marchetti, John A.; Betschart, James F.; Suffern, J. Samuel

    1992-01-01

    In order to provide effective leadership and to ensure a consistent pollution prevention effort in all of its production facilities and laboratories, Defense Programs (DP) Headquarters, in close cooperation with the Field, has developed a strategic plan for its Pollution Prevention Program. The strategic plan is built upon the history of waste minimization, waste reduction, and pollution prevention activity to date, and articulates both long- and short-term strategies to ensure program initiation, growth, and stability. The organization of the program, including Headquarters staffing and linkages to the Geld, is described. Life-cycle analysis of program barriers and bottlenecks, along with associated initiatives and action plans are discussed. (author)

  9. Development and Implementation of a Program Management Maturity Model

    Energy Technology Data Exchange (ETDEWEB)

    Hartwig, Laura; Smith, Matt

    2008-12-15

    In 2006, Honeywell Federal Manufacturing & Technologies (FM&T) announced an updatedvision statement for the organization. The vision is “To be the most admired team within the NNSA [National Nuclear Security Administration] for our relentless drive to convert ideas into the highest quality products and services for National Security by applying the right technology, outstanding program management and best commercial practices.” The challenge to provide outstanding program management was taken up by the Program Management division and the Program Integration Office (PIO) of the company. This article describes how Honeywell developed and deployed a program management maturity model to drive toward excellence.

  10. What history tells us XXI. Apoptosis and programmed cell death

    Indian Academy of Sciences (India)

    2010-04-30

    Apr 30, 2010 ... Home; Journals; Journal of Biosciences; Volume 35; Issue 2. What history tells us XXI. Apoptosis and programmed cell death: when biological categories are blurred. Michel Morange. Series Volume 35 Issue 2 June 2010 pp 177-181 ...

  11. What history tells us XXI. Apoptosis and programmed cell death ...

    Indian Academy of Sciences (India)

    2010-04-30

    Apr 30, 2010 ... Home; Journals; Journal of Biosciences; Volume 35; Issue 2. What history tells us XXI. Apoptosis and programmed cell death: when biological categories are blurred. Michel Morange. Series Volume 35 Issue 2 June 2010 pp 177-181 ...

  12. Mitotic bookmarking in development and stem cells.

    Science.gov (United States)

    Festuccia, Nicola; Gonzalez, Inma; Owens, Nick; Navarro, Pablo

    2017-10-15

    The changes imposed on the nucleus, chromatin and its regulators during mitosis lead to the dismantlement of most gene regulatory processes. However, an increasing number of transcriptional regulators are being identified as capable of binding their genomic targets during mitosis. These so-called 'mitotic bookmarking factors' encompass transcription factors and chromatin modifiers that are believed to convey gene regulatory information from mother to daughter cells. In this Primer, we review mitotic bookmarking processes in development and stem cells and discuss the interest and potential importance of this concept with regard to epigenetic regulation and cell fate transitions involving cellular proliferation. © 2017. Published by The Company of Biologists Ltd.

  13. Virtual reality based support system for layout planning and programming of an industrial robotic work cell.

    Science.gov (United States)

    Yap, Hwa Jen; Taha, Zahari; Dawal, Siti Zawiah Md; Chang, Siow-Wee

    2014-01-01

    Traditional robotic work cell design and programming are considered inefficient and outdated in current industrial and market demands. In this research, virtual reality (VR) technology is used to improve human-robot interface, whereby complicated commands or programming knowledge is not required. The proposed solution, known as VR-based Programming of a Robotic Work Cell (VR-Rocell), consists of two sub-programmes, which are VR-Robotic Work Cell Layout (VR-RoWL) and VR-based Robot Teaching System (VR-RoT). VR-RoWL is developed to assign the layout design for an industrial robotic work cell, whereby VR-RoT is developed to overcome safety issues and lack of trained personnel in robot programming. Simple and user-friendly interfaces are designed for inexperienced users to generate robot commands without damaging the robot or interrupting the production line. The user is able to attempt numerous times to attain an optimum solution. A case study is conducted in the Robotics Laboratory to assemble an electronics casing and it is found that the output models are compatible with commercial software without loss of information. Furthermore, the generated KUKA commands are workable when loaded into a commercial simulator. The operation of the actual robotic work cell shows that the errors may be due to the dynamics of the KUKA robot rather than the accuracy of the generated programme. Therefore, it is concluded that the virtual reality based solution approach can be implemented in an industrial robotic work cell.

  14. PVSIM{copyright}: A simulation program for photovoltaic cells, modules, and arrays

    Energy Technology Data Exchange (ETDEWEB)

    King, D.L.; Dudley, J.K.; Boyson, W.E.

    1996-06-01

    An electrical simulation model for photovoltaic cells, modules, and arrays has been developed that will be useful to a wide range of analysts in the photovoltaic industry. The Microsoft{reg_sign} Windows{trademark} based program can be used to analyze individual cells, to analyze the effects of cell mismatch or reverse bias(`hot spot`) heating in modules and to analyze the performance of large arrays of modules including bypass and blocking diodes. User defined statistical variance can be applied to the fundamental parameters used to simulate the cells and diodes. The model is most appropriate for cells that can be accurately modeled using a two-diode equivalent circuit. This paper describes the simulation program and illustrates its versatility with examples.

  15. Development of a safety and regulation systems simulation program II

    International Nuclear Information System (INIS)

    1985-05-01

    This report describes the development of a safety and regulation systems simulation program under contract to the Atomic Energy Control Board of Canada. A systems logic interaction simulation (SLISIM) program was developed for the AECB's HP-1000 computer which operates in the interactive simulation (INSIM) program environment. The SLISIM program simulates the spatial neutron dynamics, the regulation of the reactor power and in this version the CANDU-PHW 600 MW(e) computerized shutdown systems' trip parameters. The modular concept and interactive capability of the INSIM environment provides the user with considerable flexibility of the setup and control of the simulation

  16. Lozenge directly activates argos and klumpfuss to regulate programmed cell death.

    Science.gov (United States)

    Wildonger, Jill; Sosinsky, Alona; Honig, Barry; Mann, Richard S

    2005-05-01

    We show that reducing the activity of the Drosophila Runx protein Lozenge (Lz) during pupal development causes a decrease in cell death in the eye. We identified Lz-binding sites in introns of argos (aos) and klumpfuss (klu) and demonstrate that these genes are directly activated targets of Lz. Loss of either aos or klu reduces cell death, suggesting that Lz promotes apoptosis at least in part by regulating aos and klu. These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development.

  17. Development of simplified process for environmentally resistant cells. Final report

    Energy Technology Data Exchange (ETDEWEB)

    King, W.J.

    1980-12-01

    A program to develop a simple, foolproof, all-vacuum solar cell manufacturing process which can be completely automated and which results in medium efficiency cells which are inherently environmentally resistant is described. All components of the completed cells are integrated into a monolithic structure with no material interfaces. The exposed materials (Si, Al/sub 2/O/sub 3/, Al, Ni) are all resistant to atmospheric attack and the junction, per se, is passivated to prevent long term degradation. Such cells are intended to be incorporated into a simple module consisting basically of a press-formed metallic superstructure with a separated glass cover for missile, etc., protection. A 5 cm x 5 cm test cell configuration was designed in which the various efficiency loss factors were adjusted to yield a 10% AMI cell. Each of the cell elements was individually optimized for combination with the others. The basic cell consists of alloyed front (Al) and back (Ag plus Ni) contacts, a multi-purpose (AR, hermetic seal, implantation oxide) front surface coating of Al/sub 2/O/sub 3/, and an implanted front junction. Implantation damage annealing and contact alloying are carried out in a simple one step thermal treatment at 870/sup 0/C using a resistance heated furnace in vacuum. The use of non-analyzed and semi-analyzed beams for fabricating these cells was developed by KCI. A final lot of 50 cells made using the semi-analyzed beam method had an average efficiency of 10.4% at AMI (28 +- 1/sup 0/C). An economic analysis predicts a manufacturing cost of $.45/peak-watt for these cells using a one machine automatic method.

  18. Developing a longitudinal cancer nursing education program in Honduras.

    Science.gov (United States)

    Sheldon, Lisa Kennedy; Wise, Barbara; Carlson, Julie R; Dowds, Cynthia; Sarchet, Vanessa; Sanchez, Jose Angel

    2013-12-01

    The present paper is a longitudinal study which aims to develop and deliver cancer nursing education conferences in Honduras using volunteer nurse educators. This program intends to (1) perform site assessments of work environments and resources for cancer care in Honduras, (2) develop cancer nursing education programs, (3) survey conference participants continuing education needs, (4) deliver cancer nursing education conferences, and (5) share data with local and global partners for future cancer programs. The study draws on a longitudinal program development with site assessments, data collection, and educational conferences at two time points. Assessments and surveys were used for conference development and delivery by volunteer nurse educators. Site assessments and conferences were delivered twice. Data were collected regarding assessments and surveys to inform program development. Survey data revealed that 65 % had internet access. Participants desired more information about handling of chemotherapy, symptom management, and palliative care. Volunteer nurse educators perform site assessments and develop educational programming for cancer nurses. Local and global partners should explore internet-based programs between site visits to create sustainable education programs.

  19. Development of Methodology for Programming Autonomous Agents

    Science.gov (United States)

    Erol, Kutluhan; Levy, Renato; Lang, Lun

    2004-01-01

    A brief report discusses the rationale for, and the development of, a methodology for generating computer code for autonomous-agent-based systems. The methodology is characterized as enabling an increase in the reusability of the generated code among and within such systems, thereby making it possible to reduce the time and cost of development of the systems. The methodology is also characterized as enabling reduction of the incidence of those software errors that are attributable to the human failure to anticipate distributed behaviors caused by the software. A major conceptual problem said to be addressed in the development of the methodology was that of how to efficiently describe the interfaces between several layers of agent composition by use of a language that is both familiar to engineers and descriptive enough to describe such interfaces unambivalently

  20. Development of Passive Fuel Cell Thermal Management Heat Exchanger

    Science.gov (United States)

    Burke, Kenneth A.; Jakupca, Ian J.; Colozza, Anthony J.

    2010-01-01

    The NASA Glenn Research Center is developing advanced passive thermal management technology to reduce the mass and improve the reliability of space fuel cell systems for the NASA Exploration program. The passive thermal management system relies on heat conduction within highly thermally conductive cooling plates to move the heat from the central portion of the cell stack out to the edges of the fuel cell stack. Using the passive approach eliminates the need for a coolant pump and other cooling loop components within the fuel cell system which reduces mass and improves overall system reliability. Previous development demonstrated the performance of suitable highly thermally conductive cooling plates that could conduct the heat, provide a sufficiently uniform temperature heat sink for each cell of the fuel cell stack, and be substantially lighter than the conventional thermal management approach. Tests were run with different materials to evaluate the design approach to a heat exchanger that could interface with the edges of the passive cooling plates. Measurements were made during fuel cell operation to determine the temperature of individual cooling plates and also to determine the temperature uniformity from one cooling plate to another.

  1. Department of Energy: Nuclear S&T workforce development programs

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, Michelle [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bala, Marsha [Idaho National Lab. (INL), Idaho Falls, ID (United States); Beierschmitt, Kelly [Idaho National Lab. (INL), Idaho Falls, ID (United States); Steele, Carolyn [Argonne National Lab. (ANL), Argonne, IL (United States); Sattelberger, Alfred P. [Argonne National Lab. (ANL), Argonne, IL (United States); Bruozas, Meridith A. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-01

    The U.S. Department of Energy (DOE) national laboratories use their expertise in nuclear science and technology (S&T) to support a robust national nuclear S&T enterprise from the ground up. Traditional academic programs do not provide all the elements necessary to develop this expertise, so the DOE has initiated a number of supplemental programs to develop and support the nuclear S&T workforce pipeline. This document catalogs existing workforce development programs that are supported by a number of DOE offices (such as the Offices of Nuclear Energy, Science, Energy Efficiency, and Environmental Management), and by the National Nuclear Security Administration (NNSA) and the Naval Reactor Program. Workforce development programs in nuclear S&T administered through the Department of Homeland Security, the Nuclear Regulatory Commission, and the Department of Defense are also included. The information about these programs, which is cataloged below, is drawn from the program websites. Some programs, such as the Minority Serving Institutes Partnership Programs (MSIPPs) are available through more than one DOE office, so they appear in more than one section of this document.

  2. Implementing sustainable development programs in Chicago

    International Nuclear Information System (INIS)

    Henderson, H.

    1994-01-01

    Achieving sustainable development requires a revision of the present view of the nature of the city as an environment, and its relation to a larger ecosystem of which it is an essential part. The environmental health of a wilderness area is inextricably related to the environmental, and economic, health of the great urban centers. The vitality of dense metropolitan areas, where population and economic activities are concentrated, is key to the preservation of productive farm lands, wildlife habitat, and open spaces. The social and economic crisis which grips many metropolitan centers, with attendant flight of industry and development to the so-called open-quotes greenfields,close quotes fundamentally spreads a broader crisis to our common ecosystem. This crisis is marked by the obliteration of habitat necessary for biodiversity, loss of fertile farm land, and the contamination of air, water and land, as an unescapable effect of the sprawl created by flight from the urban centers. The removal of false conceptual distinctions between the city and nature, distinctions that are unfortunately at the heart of so much of American environmental philosophy, is key to the concept of 'sustainable development.' This article sets forth how the City of Chicago is implementing this understanding of the nature of the urban environment, in pursuit of sustainable development within the city

  3. Sustainable Development Policy Institute Immersion Program on ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Moreover, university students in the public sector education system are not exposed to academic culture, research standards and methodologies that are ... Development Policy Institute (SDPI) to train a core pool of graduates and young professionals to undertake social science research in Pakistan and South Asia.

  4. Implementing sustainable development programs in Chicago

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, H.

    1994-12-31

    Achieving sustainable development requires a revision of the present view of the nature of the city as an environment, and its relation to a larger ecosystem of which it is an essential part. The environmental health of a wilderness area is inextricably related to the environmental, and economic, health of the great urban centers. The vitality of dense metropolitan areas, where population and economic activities are concentrated, is key to the preservation of productive farm lands, wildlife habitat, and open spaces. The social and economic crisis which grips many metropolitan centers, with attendant flight of industry and development to the so-called {open_quotes}greenfields,{close_quotes} fundamentally spreads a broader crisis to our common ecosystem. This crisis is marked by the obliteration of habitat necessary for biodiversity, loss of fertile farm land, and the contamination of air, water and land, as an unescapable effect of the sprawl created by flight from the urban centers. The removal of false conceptual distinctions between the city and nature, distinctions that are unfortunately at the heart of so much of American environmental philosophy, is key to the concept of `sustainable development.` This article sets forth how the City of Chicago is implementing this understanding of the nature of the urban environment, in pursuit of sustainable development within the city.

  5. Next Generation Drivetrain Development and Test Program

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan; Erdman, Bill; Blodgett, Doug; Halse, Chris; Grider, Dave

    2015-11-03

    This presentation was given at the Wind Energy IQ conference in Bremen, Germany, November 30 through December 2, 2105. It focused on the next-generation drivetrain architecture and drivetrain technology development and testing (including gearbox and inverter software and medium-voltage inverter modules.

  6. Effective Software Engineering Leadership for Development Programs

    Science.gov (United States)

    Cagle West, Marsha

    2010-01-01

    Software is a critical component of systems ranging from simple consumer appliances to complex health, nuclear, and flight control systems. The development of quality, reliable, and effective software solutions requires the incorporation of effective software engineering processes and leadership. Processes, approaches, and methodologies for…

  7. Plasma thruster development program at the IRS

    Science.gov (United States)

    Auweter-Kurtz, Monika

    Since the early eighties the development of plasma thrusters has been an important research topic at the IRS, where a broad spectrum of stationary plasma thrusters has been investigated experimentally as well as theoretically. High power MPD thrusters (50 kW-1 MW) and a wide range of thermal arcjets (0.5-150 kW) are developed under contracts with ESA, NASA, USAF, USNAVY and with German funding. The IRS has excellent installations for continuous tests of high power accelerators. The high current power supply is a current regulated d.c. thyristor rectifier of 6 MW. The maximum current is 48 kA with a ripple less than 1%. The vacuum system is a roots pump system consisting of four stages with a total suction power of about 250,000 m 3/h at 1 Pa. Eight vacuum tanks of different sizes are connected to this system; six of them are used for plasma thruster development and two serve as plasma wind tunnels. For low power arcjet development and basic cathode erosion experiments four additional independent test stands are available.

  8. Motor Development Programming in Trisomic-21 Babies

    Science.gov (United States)

    Sanz, Teresa; Menendez, Javier; Rosique, Teresa

    2011-01-01

    The present study contributes to the understanding of gross motor development in babies with Down's syndrome. Also, it facilitates the comprehension of the efficiency of the early motor stimulation as well as of beginning it as early as possible. We worked with two groups of babies with Down's syndrome, beginning the early motor training in each…

  9. Tools for Nanotechnology Education Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Dorothy Moore

    2010-09-27

    The overall focus of this project was the development of reusable, cost-effective educational modules for use with the table top scanning electron microscope (TTSEM). The goal of this project's outreach component was to increase students' exposure to the science and technology of nanoscience.

  10. A recommended program of tritium monitoring research and development

    International Nuclear Information System (INIS)

    Nickerson, S.B.; Gerdingh, R.F.; Penfold, K.

    1982-10-01

    This report presents recommendations for programs of research and development in tritium monitoring instrumentation. These recommendations, if implemented, will offer Canadian industry the opportunity to develop marketable instruments. The major recommendations are to assist in the development and promotion of two Chalk River Nuclear Laboratories' monitors and an Ontario Hydro monitor, and to support research and development of a surface monitor

  11. Program Development for Primary School Teachers' Critical Thinking

    Science.gov (United States)

    Boonjeam, Waraporn; Tesaputa, Kowat; Sri-ampai, Anan

    2017-01-01

    The objectives of this research were: 1) to study the elements and indicators of primary school teachers' critical thinking, 2) to study current situation, desirable situation, development technique, and need for developing the primary school teachers' critical thinking, 3) to develop the program for developing the primary school teachers'…

  12. [Development of the program evaluation measurement of continuing nursing education programs].

    Science.gov (United States)

    Jho, Mi Young; Kim, Miyoung

    2013-04-01

    This study was done to develop a measurement tool for evaluation of continuing nursing education programs and to verify its validity for effective management and quality of education programs. The draft of the evaluation measurement was developed from consultation with professionals, focus group interviews targeting groups of nurses, and individual interviews with education program planners. After 6 professionals examined content validity, 46 items were retained. A pilot-survey was conducted to confirm the time required to complete the questionnaire and the level of understanding of general content and each item in the questionnaire. Construct validity was verified through exploratory factor analysis of data from a survey with 44 items completed by 452 nurses and 59 education program planners. The final evaluation measurement for continuing nursing education programs consisted of 6 evaluation factors and 36 evaluation items. The 6 evaluation factors included identifying program goals and target groups, program planning, performance, operation and management, program outcomes, and program effectiveness. The evaluation measurement for continuing nursing education programs developed in this study is considered suitable to utilize as an evaluation measurement of the quality of continuing education programs for nurses.

  13. Automotive Fuel Processor Development and Demonstration with Fuel Cell Systems

    Energy Technology Data Exchange (ETDEWEB)

    Nuvera Fuel Cells

    2005-04-15

    The potential for fuel cell systems to improve energy efficiency and reduce emissions over conventional power systems has generated significant interest in fuel cell technologies. While fuel cells are being investigated for use in many applications such as stationary power generation and small portable devices, transportation applications present some unique challenges for fuel cell technology. Due to their lower operating temperature and non-brittle materials, most transportation work is focusing on fuel cells using proton exchange membrane (PEM) technology. Since PEM fuel cells are fueled by hydrogen, major obstacles to their widespread use are the lack of an available hydrogen fueling infrastructure and hydrogen's relatively low energy storage density, which leads to a much lower driving range than conventional vehicles. One potential solution to the hydrogen infrastructure and storage density issues is to convert a conventional fuel such as gasoline into hydrogen onboard the vehicle using a fuel processor. Figure 2 shows that gasoline stores roughly 7 times more energy per volume than pressurized hydrogen gas at 700 bar and 4 times more than liquid hydrogen. If integrated properly, the fuel processor/fuel cell system would also be more efficient than traditional engines and would give a fuel economy benefit while hydrogen storage and distribution issues are being investigated. Widespread implementation of fuel processor/fuel cell systems requires improvements in several aspects of the technology, including size, startup time, transient response time, and cost. In addition, the ability to operate on a number of hydrocarbon fuels that are available through the existing infrastructure is a key enabler for commercializing these systems. In this program, Nuvera Fuel Cells collaborated with the Department of Energy (DOE) to develop efficient, low-emission, multi-fuel processors for transportation applications. Nuvera's focus was on (1) developing fuel

  14. Fuel cells: a survey of current developments

    Science.gov (United States)

    Cropper, Mark A. J.; Geiger, Stefan; Jollie, David M.

    Since the first practical uses of fuel cells were developed, it has become clear that they could find use in many products over a wide power range of milliwatts to tens of megawatts. Throughout the 1990s, and later, there has been significant work carried out on adapting the various different fuel cell technologies for use in targetted consumer and industrial applications. This paper discusses these developments and gives details on the specific market segments for providing power to vehicles, portable devices and large- and small-scale stationary power generation.

  15. Laboratory Directed Research and Development Program FY 2006 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2007-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the US Departmental of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2006. The associated FY 2006 ORNL LDRD Self-Assessment (ORNL/PPA-2007/2) provides financial data about the FY 2006 projects and an internal evaluation of the program's management process.

  16. Fuel cells for transportation program: FY1997 national laboratory annual report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The Department of Energy (DOE) Fuel Cells for Transportation Program is structured to effectively implement the research and development (R and D) required for highly efficient, low or zero emission fuel cell power systems to be a viable replacement for the internal combustion engine in automobiles. The Program is part of the Partnership for a New Generation of Vehicles (PNGV), a government-industry initiative aimed at development of an 80 mile-per-gallon vehicle. This Annual Report summarizes the technical accomplishments of the laboratories during 1997. Participants include: Argonne National Laboratory (ANL), Brookhaven National Laboratory (BNL), Lawrence Berkeley National Laboratory (LBNL), Los Alamos National Laboratory (LANL), Oak Ridge National Laboratory (ORNL), Pacific Northwest National Laboratory (PNNL), and the National Renewable Energy Laboratory (NREL). During 1997, the laboratory R and D included one project on solid oxide fuel cells; this project has since been terminated to focus Department resources on PEM fuel cells. The technical component of this report is divided into five key areas: fuel cell stack research and development; fuel processing; fuel cell modeling, testing, and evaluation; direct methanol PEM fuel cells; and solid oxide fuel cells.

  17. Collaborative development of Estonian nuclear master's program

    International Nuclear Information System (INIS)

    Tkaczyk, A. H.; Kikas, A.; Realo, E.; Kirm, M.; Kiisk, M.; Isakar, K.; Suursoo, S.; Koch, R.; Feldbach, E.; Lushchik, A.; Reivelt, K.

    2012-01-01

    In 2009 Estonia approved the National Development Plan for the Energy Sector, including the nuclear energy option. This can be realized by construction of a nuclear power plant (NPP) in Estonia or by participation in neighboring nuclear projects (e.g., Lithuania and/or Finland). Either option requires the availability of competent personnel. It is necessary to prepare specialists with expertise in all aspects related to nuclear infrastructure and to meet workforce needs (e.g. energy enterprises, public agencies, municipalities). Estonia's leading institutions of higher education and research with the support of the European Social Fund have announced in this context a new nuclear master's curriculum to be developed. The language of instruction will be English. (authors)

  18. Overview of molten carbonate fuel cell technology development

    Science.gov (United States)

    Williams, M. C.; Parsons, E. L., Jr.; Mayfield, M. J.

    The molten carbonate fuel cell (MCFC) has been identified as a promising energy conversion product for development and commercialization. Overall DOE MCFC program goal is to develop and commercialize low-cost, simple fuel cell systems. Objective of the MCFC program is to develop and demonstrate MCFC power plant systems. Significant progress has already been made in developing the MCFC technology in the U.S. Manufacturing and test facility development and testing by the MCFC developers has also been significant. Product improvement issues need to be resolved to vector the MCFC technology from its current status to a multi-fuel, integrated, simple, low-cost, modular, market-responsive power plant product. MCFC's must undergo continuing product refinement to ensure that durability and cost reduction through modularization and stack manufacturing scale-up occurs. MCFC developers need to continue to be responsive to end-users in potential markets. MCFC's appear to have a place in a decentralized power industry future. Natural gas availability appears to play a key role in MCFC commercialization.

  19. The European Dimension of the Global Urban Development Program

    Directory of Open Access Journals (Sweden)

    Bubenko Pavlo T.

    2017-11-01

    Full Text Available The article is aimed at studying the process of evolutionary formation of the EU Cities Development Program and analyzing the strategic instrumentarium for the urban development within the currently established EU urban policy at the present stage. The key features of the process of formation of the EU urban policy have been analyzed, the main stages of evolutionary formation of the integrated EU Cities Development Program have been defined and described. In the context of ensuring an integrated approach to the sustainable urban development and complementary positioning of urban development in the EU’s territorial development and cohesion strategies, the European Union’s normative and legal framework on urban development was researched. As a result of the conducted research, the strategic instrumentarium of implementation of the EU Cities Development Program has been systematized.

  20. The zinc finger protein ZAT11 modulates paraquat-induced programmed cell death in Arabidopsis thaliana

    NARCIS (Netherlands)

    Qureshi, Muhammad Kamran; Sujeeth, Neerakkal; Gechev, Tsanko S.; Hille, Jacques

    Plants use programmed cell death (PCD) as a tool in their growth and development. PCD is also involved in defense against different kinds of stresses including pathogen attack. In both types of PCD, reactive oxygen species (ROS) play an important role. ROS is not only a toxic by-product but also

  1. Informative intervention programs to reading comprehension: Development and implementation

    OpenAIRE

    CUNHA, Vera Lúcia Orlandi; CAPELLINI, Simone Aparecida

    2017-01-01

    Abstract The objective of this study was to develop two intervention programs to promote reading comprehension, one for narrative texts and one for expository texts, to be used by 3rd-5th grade elementary school teachers in the classroom. The applicability of the programs was verified. A total of 143 elementary school students in 3rd, 4th, and 5th grades participated in this study. The students were evaluated before and after the administration of the intervention programs. There were signifi...

  2. Clean coal technologies: Research, development, and demonstration program plan

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    The US Department of Energy, Office of Fossil Energy, has structured an integrated program for research, development, and demonstration of clean coal technologies that will enable the nation to use its plentiful domestic coal resources while meeting environmental quality requirements. The program provides the basis for making coal a low-cost, environmentally sound energy choice for electric power generation and fuels production. These programs are briefly described.

  3. Research and development program in reactor safety for NUCLEBRAS

    International Nuclear Information System (INIS)

    Pinheiro, R.B.; Resende Lobo, A.A. de; Horta, J.A.L.; Avelar Esteves, F. de; Lepecki, W.P.S.; Mohr, K.; Selvatici, E.

    1984-01-01

    With technical assistance from the IAEA, it was established recently an analytical and experimental Research and Development Program for NUCLEBRAS in the area of reactor safety. The main objectives of this program is to make possible, with low investments, the active participation of NUCLEBRAS in international PWR safety research. The analytical and experimental activities of the program are described with some detail, and the main results achieved up to now are presented. (Author) [pt

  4. Baseline Gas Turbine Development Program ninth quarterly progress report

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, C.E.

    1975-01-31

    Progress is reported for a program to demonstrate by 1976 an experimental gas turbine powered automobile which meets the 1978 Federal Emissions Standards, has significantly improved fuel economy, and is competitive in performance, reliability, and potential manufacturing cost with the conventional piston engine powered, standard size American automobile. NASA completed the first phase of their baseline engine heat balance tests, and an upgraded engine compressor is being scaled for test. EPA completed their report on vehicle tests including emissions and vehicle performance, and a new endurance engine is on test. Significant development progress was made on both fixed and variable geometry combustors. After 45 hours of engine operation with Vendor A ceramic regenerator, no significant deterioration of the matrix, seals, or elastomeric mount was encountered. Ceramic regenerator stress analysis has commenced. Additional developments in non-nickel oxide regenerator rubbing seals are encouraging. The first preprototype integrated control system is in vehicle operation. Control adaptation for variable inlet guide vanes and water injection is progressing. AiRefrac turbine wheels were verified dimensionally and are being processed for engine testing. Water injection tests with a four nozzle system were run, and additional performance documentation of variable inlet guide vanes was obtained. Linerless insulation is on test in the free rotor engine, the new endurance engine, and a performance engine. The free rotor engine completed test cell checkout and was installed in a vehicle. Vehicle checkout, including a preprototype integrated control, is underway. Detailed specifications of the upgraded engine were written.

  5. Unraveling Natural Killer T-Cells Development

    Directory of Open Access Journals (Sweden)

    Sabrina Bianca Bennstein

    2018-01-01

    Full Text Available Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT cell biology is needed. The first step is to learn more about NKT development within the thymus. Recent studies suggest lineage separation of murine iNKT cells into iNKT1, iNKT2, and iNKT17 cells instead of shared developmental stages. This review will focus on these new studies and will discuss the evidence for lineage separation in contrast to shared developmental stages. The author will also highlight the classifications of murine iNKT cells according to identified transcription factors and cytokine production, and will discuss transcriptional and posttranscriptional regulations, and the role of mammalian target of rapamycin. Finally, the importance of these findings for human cancer therapy will be briefly discussed.

  6. Nuclear program of Iran plans and development

    International Nuclear Information System (INIS)

    2016-01-01

    Described are the history of nuclear energy planning in Iran and the development of the Bushehr Nuclear Power Plant (BNPP-1) project and its impact on the competency building in national companies, nuclear safety infrastructure, training activities, public awareness and acceptance. The activities of Nuclear Engineering Department is also presented. In order to enhance technical support services to BNPP1 and also to use capabilities of other companies in the international arena and in line with safe and reliable operation of Bushehr Nuclear Power Plant, NPPD/TAVANA Company has attempted to make contact with many companies outside the country

  7. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

  8. Laboratory Directed Research and Development Program

    International Nuclear Information System (INIS)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium

  9. A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae.

    Science.gov (United States)

    Bergé, Matthieu J; Mercy, Chryslène; Mortier-Barrière, Isabelle; VanNieuwenhze, Michael S; Brun, Yves V; Grangeasse, Christophe; Polard, Patrice; Campo, Nathalie

    2017-11-20

    Competence for genetic transformation is a differentiation program during which exogenous DNA is imported into the cell and integrated into the chromosome. In Streptococcus pneumoniae, competence develops transiently and synchronously in all cells during exponential phase, and is accompanied by a pause in growth. Here, we reveal that this pause is linked to the cell cycle. At least two parallel pathways impair peptidoglycan synthesis in competent cells. Single-cell analyses demonstrate that ComM, a membrane protein induced during competence, inhibits both initiation of cell division and final constriction of the cytokinetic ring. Competence also interferes with the activity of the serine/threonine kinase StkP, the central regulator of pneumococcal cell division. We further present evidence that the ComM-mediated delay in division preserves genomic integrity during transformation. We propose that cell division arrest is programmed in competent pneumococcal cells to ensure that transformation is complete before resumption of cell division, to provide this pathogen with the maximum potential for genetic diversity and adaptation.

  10. Development of Thin Solar Cells for Space Applications at NASA Glenn Research Center

    Science.gov (United States)

    Dickman, John E.; Hepp, Aloysius; Banger, Kulbinder K.; Harris, Jerry D.; Jin, Michael H.

    2003-01-01

    NASA GRC Thin Film Solar Cell program is developing solar cell technologies for space applications which address two critical metrics: higher specific power (power per unit mass) and lower launch stowed volume. To be considered for space applications, an array using thin film solar cells must offer significantly higher specific power while reducing stowed volume compared to the present technologies being flown on space missions, namely crystalline solar cells. The NASA GRC program is developing single-source precursors and the requisite deposition hardware to grow high-efficiency, thin-film solar cells on polymer substrates at low deposition temperatures. Using low deposition temperatures enables the thin film solar cells to be grown on a variety of polymer substrates, many of which would not survive the high temperature processing currently used to fabricate thin film solar cells. The talk will present the latest results of this research program.

  11. Dance Educator Enrichment Program (DEEP): A Model for Professional Development

    Science.gov (United States)

    Sofras, Pamela Anderson; Emory-Maier, Ambre

    2005-01-01

    In 2001, North Carolina Dance Theatre, The University of North Carolina at Charlotte, and the Charlotte-Mecklenburg School system joined forces to create a multidimensional, professional development program for dance professionals (teachers and artists) in the public schools called, The Dance Educator Enrichment Program (DEEP). DEEP was designed…

  12. 7 CFR 371.9 - Policy and Program Development.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Policy and Program Development. 371.9 Section 371.9 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION... effects of APHIS programs to ensure their compliance with environmental laws and regulations and providing...

  13. Development of a Program Specific Locator Test. Final Report.

    Science.gov (United States)

    Benn, Robert J.

    A project was undertaken to develop a series of program-specific vocational locator tests (PSVLTs) that would consist of subject-specific questions in three academic disciplines--writing, reading, and mathematics--for use in predicting vocational students' success in their vocational programs. As a prelude to constructing the tests, project staff…

  14. Laboratory Directed Research and Development Program Assessment for FY 2014

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-03-01

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy in accordance with DOE Order 413.2B dated April 19, 2006. This report fulfills that requirement.

  15. development of a computer program for the design of auger

    African Journals Online (AJOL)

    User

    program was developed for the above processes to remove the constraints of the classical ... Results of evaluation tests show that the program is efficient in the ..... C. C AUGER CONVEYOR DESIGN FOR CHART A MATERIALS. 100 WRITE(*,2). WRITE(*,4)'DESIGN OF SCREW FOR CHART A MATERIALS'. WRITE(* ...

  16. Developing fire management mixes for fire program planning

    Science.gov (United States)

    Armando González-Cabán; Patricia B. Shinkle; Thomas J. Mills

    1986-01-01

    Evaluating economic efficiency of fire management program options requires information on the firefighting inputs, such as vehicles and crews, that would be needed to execute the program option selected. An algorithm was developed to translate automatically dollars allocated to type of firefighting inputs to numbers of units, using a set of weights for a specific fire...

  17. Programming Embedded Systems With C and GNU Development Tools

    CERN Document Server

    Barr, Michael

    2009-01-01

    Whether you're writing your first embedded program, designing the latest generation of hand-held whatchamacalits, or managing the people who do, this book is for you. Programming Embedded Systems will help you develop the knowledge and skills you need to achieve proficiency with embedded software.

  18. Development of an Interdisciplinary Undergraduate Bioengineering Program at Lehigh University

    Science.gov (United States)

    Herz, Lori; Russo, M. Jean; Ou-Yang, H. Daniel; El-Aasser, Mohamed; Jagota, Anand; Tatic-Lucic, Svetlana; Ochs, John

    2011-01-01

    The undergraduate Bioengineering Program at Lehigh University was established as part of the university's Bioscience and Biotechnology Initiative with support from the National Science Foundation through a grant from its Division of Engineering Education and Centers (EEC). The objective here is to describe the program development and…

  19. LBNL Laboratory Directed Research and Development Program FY2016

    Energy Technology Data Exchange (ETDEWEB)

    Ho, D.

    2017-03-01

    The Berkeley Lab Laboratory Directed Research and Development Program FY2016 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the supported projects and summarizes their accomplishments. It constitutes a part of the LDRD program planning and documentation process that includes an annual planning cycle, project selection, implementation and review.

  20. Developing Recognition Programs for Units within Student Affairs.

    Science.gov (United States)

    Avery, Cynthia M.

    2001-01-01

    According to many psychologists, the connections between motivation and rewards and recognition are crucial to employee satisfaction. A plan for developing a multi-layered recognition program within a division of student affairs is described. These recognitions programs are designed taking into account the differences in perceptions of awards by…

  1. Development of a Computer Program for the Design of Auger ...

    African Journals Online (AJOL)

    A computer program was developed for the above processes to remove the constraints of the classical approach. The program which is iterative and menu driven, accepts relevant input data (material to be conveyed, required capacity, elevations involved, etc) and does the required calculations, selection and optimization.

  2. Embracing Agile methodology during DevOps Developer Internship Program

    OpenAIRE

    Patwardhan, Amol; Kidd, Jon; Urena, Tiffany; Rajgopalan, Aishwarya

    2016-01-01

    The DevOps team adopted agile methodologies during the summer internship program as an initiative to move away from waterfall. The DevOps team implemented the Scrum software development strategy to create an internal data dictionary web application. This article reports on the transition process and lessons learned from the pilot program.

  3. Developing College English as a Second Language (ESL) Programs

    Science.gov (United States)

    Orlova, Irina A.; Kennedy, Jelane A.

    2009-01-01

    This article examines available literature on college English as a Second Language (ESL) programs. The literature available on college ESL programs falls into three categories: (1) research reports and articles, (2) recent theoretical discussions on ESL teaching, and (3) thought pieces discussing college ESL curriculum development and assessment…

  4. Regional Innovation System Strengthening Program (SIDa as an Exit Strategy National Community Development Program (PNPM

    Directory of Open Access Journals (Sweden)

    Teguh Narutomo

    2014-06-01

    Full Text Available The aim of this study was to evaluate the PNPM program and follow the program with SIDA Strengthening Program. The research method used is a qualitative method approach of this research through the evaluation research design that builds on the CIPP evaluation model (Context-Input-Process-Product. Since the failure of theories and models of development are too glorifies growth, makes many people turn to focus on people development, which includes requiring optimization of local resources, participation, and empowerment. Since then, "empowerment" which was introduced in Indonesia has been anesthetized and made many hopes among many parties. In 2007 started the National Program for Community Empowerment (PNPM which continue Kecamatan Development Program (KDP. PNPM 2014 which is part of the United Indonesia Cabinet Volume 2 is going to end. For that we need to look for an exit strategy program that can maintain sustainability of PNPM. Regional Innovation Systems Strengthening Program (SIDA is a program of the whole process in one system to foster innovation made between government institutions, local governments, research institutions, educational institutions, innovation support institutions, businesses, and communities in areas that have been implemented since the 2012 SIDA program is an empowerment program as well, both to the public and even empowering to all elements such as academia, private industry, government and society.

  5. Considering public confidence in developing regulatory programs

    International Nuclear Information System (INIS)

    Collins, S.J.

    2001-01-01

    In the area of public trust and in any investment, planning and strategy are important. While it is accepted in the United States that an essential part of our mission is to leverage our resources to improving Public Confidence this performance goal must be planned for, managed and measured. Similar to our premier performance goal of Maintaining Safety, a strategy must be developed and integrated with our external stake holders but with internal regulatory staff as well. In order to do that, business is to be conducted in an open environment, the basis for regulatory decisions has to be available through public documents and public meetings, communication must be done in clear and consistent terms. (N.C.)

  6. Laser transit anemometer software development program

    Science.gov (United States)

    Abbiss, John B.

    1989-01-01

    Algorithms were developed for the extraction of two components of mean velocity, standard deviation, and the associated correlation coefficient from laser transit anemometry (LTA) data ensembles. The solution method is based on an assumed two-dimensional Gaussian probability density function (PDF) model of the flow field under investigation. The procedure consists of transforming the data ensembles from the data acquisition domain (consisting of time and angle information) to the velocity space domain (consisting of velocity component information). The mean velocity results are obtained from the data ensemble centroid. Through a least squares fitting of the transformed data to an ellipse representing the intersection of a plane with the PDF, the standard deviations and correlation coefficient are obtained. A data set simulation method is presented to test the data reduction process. Results of using the simulation system with a limited test matrix of input values is also given.

  7. Certification Programs for Criminalists - Historical Development.

    Science.gov (United States)

    Bernett, P D

    2008-01-01

    Certification is the process by which individual practitioners of a profession are deemed competent, by a peer review process, to practice that profession. Criminalistics is a rather young profession, and until the recent publicity occasioned by a myriad of television dramas and documentaries, a rather obscure one. There has been little oversight of the profession and little call for such oversight until the 1970s. The calls for oversight primarily came from those outside the profession and with only a peripheral interest in the profession. In response, the profession itself began to consider the development of a process of self-review and to establish certification criteria (a) by which the competence of practitioners could be assessed in a way that would be acceptable to practitioners; (b) equitable to the diverse jobs requirements of various practitioners; useful for external evaluation by users of professional services; and, above all, (c) be a realistic method to evaluate the ability of the practitioner to engage in the professional practice of forensic science. Professional certification of criminalists was first suggested at a meeting of the California Association of Criminalists (CAC) in 1975. This initial proposal was taken to the broader national criminalistics community through the efforts of the Criminalistics Certification Study Committee (CCSC) beginning in 1976. Subjected in 1978 to a national referendum of practitioners, CCSC's proposal was rejected. Undaunted by national rejection, in 1986 the CAC renewed efforts to develop a certification process for its members, which resulted in the offering of the first certification examination in 1989. Since the initial certification examination by the CAC, certification of criminalists has evolved through the activities of the American Board of Criminalistics (ABC). Efforts have been continuously made to refine the process to more closely reflect the demands of the profession. The evolution has been slow

  8. Integrating Professional Development into STEM Graduate Programs: Student-Centered Programs for Career Preparation

    Science.gov (United States)

    Lautz, L.; McCay, D.; Driscoll, C. T.; Glas, R. L.; Gutchess, K. M.; Johnson, A.; Millard, G.

    2017-12-01

    Recognizing that over half of STEM Ph.D. graduates are finding work outside of academia, a new, NSF-funded program at Syracuse University, EMPOWER (or Education Model Program on Water-Energy Research) is encouraging its graduate students to take ownership of their graduate program and design it to meet their anticipated needs. Launched in 2016, EMPOWER's goal is to prepare graduate students for careers in the water-energy field by offering targeted workshops, professional training coursework, a career capstone experience, a professional development mini-grant program, and an interdisciplinary "foundations" seminar. Through regular student feedback and program evaluation, EMPOWER has learned some important lessons this first year: career options and graduate students' interests are diverse, requiring individualized programs designed to meet the needs of prospective employers and employees; students need exposure to the range of careers in their field to provide a roadmap for designing their own graduate school experience; effective programs nurture a culture that values professional development thereby giving students permission to pursue career paths and professional development opportunities that meet their own needs and interests; and existing university resources support the effective and efficient integration of professional development activities into graduate programs. Many of the positive outcomes experienced by EMPOWER students may be achieved in departmental graduate programs with small changes to their graduate curricula.

  9. Analysing Scenarios of Cell Population System Development

    Directory of Open Access Journals (Sweden)

    M. S. Vinogradova

    2014-01-01

    Full Text Available The article considers an isolated population system consisting of two types of human stem cells, namely normal cells and cells with chromosomal abnormalities (abnormal ones. The system develops in the laboratory (in vitro. The article analyses possible scenarios of the population system development, which are implemented for different values of its parameters. An investigated model of the cell population system takes into account the limited resources. It is represented as a system of two nonlinear differential equations with continuous right-hand part. The model is considered with non-negative values of the variables; the domain is divided into four sets. The model feature is that in each set the right part of the system of differential equations has a different form.The article analyses a quality of the rest points of the system in each of four sets. The analytical conditions for determination of the number of rest points and the quality of rest points, with, at least, one zero coordinate, are obtained.It is shown that the population system under study cannot have more than two points of rest, both coordinates of which are positive (non-zero. It is difficult to determine quality of such rest points depending on the model parameters due to the complexity of the expressions, which define the systems of the first approximation, recorded in a neighborhood of these points of rest. Numerical research results of the stability of these points of rest are obtained, and phase portraits with the specified specific values of the system parameters are demonstrated. The main scenarios for the cell population development are adduced. Analysis of mathematical model shows that a cell population system may remain the system consisting of populations of normal and abnormal cells; it can degenerate into a population of abnormal cells or perish. The scenario, in which there is only the population of normal cells, is not implemented. The numerical simulation

  10. The NASA "PERS" Program: Solid Polymer Electrolyte Development for Advanced Lithium-Based Batteries

    Science.gov (United States)

    Baldwin, Richard S.; Bennett, William R.

    2007-01-01

    In fiscal year 2000, The National Aeronautics and Space Administration (NASA) and the Air Force Research Laboratory (AFRL) established a collaborative effort to support the development of polymer-based, lithium-based cell chemistries and battery technologies to address the next generation of aerospace applications and mission needs. The ultimate objective of this development program, which was referred to as the Polymer Energy Rechargeable System (PERS), was to establish a world-class technology capability and U.S. leadership in polymer-based battery technology for aerospace applications. Programmatically, the PERS initiative exploited both interagency collaborations to address common technology and engineering issues and the active participation of academia and private industry. The initial program phases focused on R&D activities to address the critical technical issues and challenges at the cell level. Out of a total of 38 proposals received in response to a NASA Research Announcement (NRA) solicitation, 18 proposals (13 contracts and 5 grants) were selected for initial award to address these technical challenges. Brief summaries of technical approaches, results and accomplishments of the PERS Program development efforts are presented. With Agency support provided through FY 2004, the PERS Program efforts were concluded in 2005, as internal reorganizations and funding cuts resulted in shifting programmatic priorities within NASA. Technically, the PERS Program participants explored, to various degrees over the lifetime of the formal program, a variety of conceptual approaches for developing and demonstrating performance of a viable advanced solid polymer electrolyte possessing the desired attributes, as well as several participants addressing all components of an integrated cell configuration. Programmatically, the NASA PERS Program was very successful, even though the very challenging technical goals for achieving a viable solid polymer electrolyte material or

  11. The development of quality assurance program for cyberknife

    International Nuclear Information System (INIS)

    Jang, Ji Sun; Lee, Dong Han; Kang, Young Nam

    2006-01-01

    Standardization quality assurance (QA)program of Cyberknife for suitable circumstances in Korea has not been established. In this research, we investigated the development of QA program for Cyberknife and evaluation of the feasibility under applications. Considering the feature of constitution for systems and the therapeutic methodology of Cyberknife, the list of quality control (QC) was established and divided dependent on the each period of operations. And then all these developed QC lists were categorized into three groups such as basic QC, delivery specific QC, and patient specific QC based on the each purpose of QA. In order to verify the validity of the established QA program, this QC lists was applied to two Cyberknife centers. The acceptable tolerance was based on the undertaking inspection list from the Cyberknife manufacturer and the QC results during last three years of two Cyberknife centers in Korea. The acquired measurement results were evaluated for the analysis of the current QA status and the verification of the propriety for the developed QA program. The current QA status of two Cyberknife centers was evaluated from the accuracy of all measurements in relation with application of the established QA program. Each measurement result was verified having a good agreement within the acceptable tolerance limit of the developed QA program. It is considered that the developed QA program in this research could be established the standardization of QC methods for Cyberknife and confirmed the accuracy and stability for the image-guided stereotactic radiotherapy

  12. A Learning Tool and Program Development for Mechatronics Design Education

    Science.gov (United States)

    Iribe, Masatsugu; Shirahata, Akihiro; Kita, Hiromasa; Sasashige, Yousuke; Dasai, Ryoichi

    In this paper we propose a new type educational program for Mechatronics design which contributes to develop the physical sense and problem solving ability of the students who study Mechatronics design. For this program we provide a new handicraft kit of 4-wheeled car which is composed of inexpensive and commonplace parts, and the performance of the assembled 4-wheeled car is sensitive to its assembly arrangement. And then we implemented this program with the handicraft kit to the university freshmen, and verified its effectiveness, and report the results of the program.

  13. Developing robotic behavior using a genetic programming model

    International Nuclear Information System (INIS)

    Pryor, R.J.

    1998-01-01

    This report describes the methodology for using a genetic programming model to develop tracking behaviors for autonomous, microscale robotic vehicles. The use of such vehicles for surveillance and detection operations has become increasingly important in defense and humanitarian applications. Through an evolutionary process similar to that found in nature, the genetic programming model generates a computer program that when downloaded onto a robotic vehicle's on-board computer will guide the robot to successfully accomplish its task. Simulations of multiple robots engaged in problem-solving tasks have demonstrated cooperative behaviors. This report also discusses the behavior model produced by genetic programming and presents some results achieved during the study

  14. Black Women's Recommendations for Developing Effective Type 2 Diabetes Programming.

    Science.gov (United States)

    Hurt, Tera R; Seawell, Asani H; Cutrona, Carolyn; O'Connor, Margaret C; Camp, Randie D; Duran, Roxanne; Elderts, Reid; Green, Chrishelda; Hara, Vanessa; Pattee, Jenna

    2017-01-01

    The purpose of this study was to learn from 29 Black women how to develop effective Type 2 diabetes programming. Three focus groups were held in Des Moines, Iowa, during fall 2012. Results highlighted themes related to diabetes knowledge, diabetes management and prevention, physical activity, diet, and diabetes management programming. Opinions were shared as to whether family members should be included in programs for supporting those diagnosed with diabetes. These results provided guidance and ideas to scholars and health care professionals aiming to improve effectiveness of diabetes programs for Black women and families.

  15. Cross software for microprocessor program development at CERN

    International Nuclear Information System (INIS)

    Eicken, H. von; Montuelle, J.; Willers, I.; Blake, J.

    1981-01-01

    Programs for a variety of microprocessors (including Intel 8080; Motorola 6800 and 6809 and 68000; and Texas Instruments 9900) can be prepared on different host computers (such as IBM 370, CDC 6000, and Nord 10) using portable programs developed at CERN. The range of cross software consists of: an assembler for each target microprocessor, a single linkage editor, a single object module librarian, and a variety of pre-loaders which convert object modules from CERN's format (CUFOM) into manufacturers' formats. The programs are written in BCPL and PASCAL, programming languages which are available on a wide range of computers. (orig.)

  16. Program Leadership from a Nordic Perspective - Managing Education Development

    DEFF Research Database (Denmark)

    Högfeldt, Anna-Karin; Cornell, Ann; Cronhjort, Mikael

    2012-01-01

    In this paper we focus on university educational development issues by investigating the program leadership at five Nordic technical universities. Specifically, the paper compares definitions, views and experiences of education leadership in the Nordic Five Tech (N5T) universities. The paper does...... their role, their possibilities to lead, and their opportunities of learning to lead. How is time for reflection and development as leaders handled at the different universities? The paper goes on to consider what impact the mandate of the leadership role has on the possibilities for developing educational...... programs. For instance, how can program directors ensure that learning objectives concerning generic skills and abilities are reached? How can program directors drive implementation of integrative and value-oriented topics such as sustainable development, innovation and entrepreneurship?...

  17. 2013 Iowa DOT engineering intern development and management program.

    Science.gov (United States)

    2013-11-01

    The Institute for Transportation (InTrans) at Iowa State University (ISU) developed an internship mentoring program in collaboration : with the Iowa Department of Transportation (DOT) to provide additional mentorship to both student interns and Iowa ...

  18. Developing an interdisciplinary certificate program in transportation planning.

    Science.gov (United States)

    2010-09-01

    This project develops and implements a graduate certificate in transportation planning. Texas A&M : University (A&M) currently offers instruction in transportation through its Master of Urban Planning (MUP) : and Civil Engineering (CE) programs; howe...

  19. Development of a University Extension Program in a Federal Penitentiary

    Science.gov (United States)

    McCleary, Charles H.

    1974-01-01

    The report documents the development and the results of the educational program in the Saskatchewan Penitentiary from 1971 through 1974. Available from: Extension Division, University of Saskatchewan, Saskatoon S7N OWO. (MW)

  20. Industrial development - consequences about the implantation of Brazilian Nuclear Program

    International Nuclear Information System (INIS)

    Syllus, C.

    1987-07-01

    The strategy to promote the growing industry participation in the Brazilian Nuclear Program, the difficulties, the measurements adopted for overcoming and the results obtained in terms of industrial development, are presented. (M.C.K.) [pt

  1. Ohio Uses Wetlands Program Development Grants to Protect Wetlands

    Science.gov (United States)

    The wetland water quality standards require the use of ORAM score to determine wetland quality. OEPA has also used these tools to evaluate wetland mitigation projects, develop performance standards for wetland mitigation banks and In Lieu Fee programs an.

  2. Guidelines for Developing Educational Programs for Cooperating Teachers.

    Science.gov (United States)

    Guyton, Edith

    1989-01-01

    Guidelines are provided for developing educational programs for cooperating teachers, or other teachers who work with beginning teachers. The guidelines have eight essential components which can be categorized as procedural, substantive, or knowledge components. (IAH)

  3. Thin polymer icemaker development and test program

    Science.gov (United States)

    Leigh, R. W.

    1991-08-01

    We have constructed and tested a small device to produce ice in ice/water mixtures using a cold fluid as the heat sink. The device is a flexible heat exchanger constructed from a thin film of a suitable polymer. When filled with circulating liquid coolant the heat exchanger consists of an inflated series of parallel tubes; ice forms on the outside in complementary half cylinders. When the circulation is cut off, gravity drains the coolant and the static head of the water bath crushes the tubes, freeing them from the ice which floats to the surface. Brine circulation is then re-started and the cycle begins again. Here we report recent testing of this device: it makes ice readily under water and easily sheds the semi-cylinders of ice over many cycles of operation. It produces ice at a rate of 10 kg/m(exp 2)-hour. It offers substantial benefits in simplicity and reliability over mechanical harvester ice making systems, and the potential for significant improvements in energy efficiency compared to systems which use a re-heat cycle to harvest the ice. A reliable method of leak detection has been developed. The device should be of substantial value to systems where efficiency and reliability are at a premium, such as slush ice for district cooling.

  4. Vehicle Technologies and Fuel Cell Technologies Program: Prospective Benefits Assessment Report for Fiscal Year 2016

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, T. S. [Argonne National Lab. (ANL), Argonne, IL (United States); Taylor, C. H. [TA Engineering, Inc., Catonsville, MD (United States); Moore, J. S. [TA Engineering, Inc., Catonsville, MD (United States); Ward, J. [United States Department of Energy, Washington, DC (United States). Office of Energy Efficiency and Renewable Energy

    2016-02-23

    Under a diverse set of programs, the Vehicle Technologies and Fuel Cell Technologies offices of DOE’s Office of Energy Efficiency and Renewable Energy invest in research, development, demonstration, and deployment of advanced vehicle, hydrogen production, delivery and storage, and fuel cell technologies. This report estimates the benefits of successfully developing and deploying these technologies (a “Program Success” case) relative to a base case (the “No Program” case). The Program Success case represents the future with completely successful deployment of Vehicle Technologies Office (VTO) and Fuel Cell Technologies Office (FCTO) technologies. The No Program case represents a future in which there is no contribution after FY 2016 by the VTO or FCTO to these technologies. The benefits of advanced vehicle, hydrogen production, delivery and storage, and fuel cell technologies were estimated on the basis of differences in fuel use, primary energy use, and greenhouse gas (GHG) emissions from light-, medium- and heavy-duty vehicles, including energy and emissions from fuel production, between the base case and the Program Success case. Improvements in fuel economy of various vehicle types, growth in the stock of fuel cell vehicles and other advanced technology vehicles, and decreased GHG intensity of hydrogen production and delivery in the Program Success case over the No Program case were projected to result in savings in petroleum use and GHG emissions. Benefits were disaggregated by individual program technology areas, which included the FCTO program and the VTO subprograms of batteries and electric drives; advanced combustion engines; fuels and lubricants; materials (for reduction in vehicle mass, or “lightweighting”); and, for medium- and heavy-duty vehicles, reduction in rolling and aerodynamic resistance. Projections for the Program Success case indicate that by 2035, the average fuel economy of on-road, light-duty vehicle stock could be 47% to 76

  5. Strategies for fuel cell product development. Developing fuel cell products in the technology supply chain

    International Nuclear Information System (INIS)

    Hellman, H.L.

    2004-01-01

    Due to the high cost of research and development and the broad spectrum of knowledge and competences required to develop fuel cell products, many product-developing firms outsource fuel cell technology, either partly or completely. This article addresses the inter-firm process of fuel cell product development from an Industrial Design Engineering perspective. The fuel cell product development can currently be characterised by a high degree of economic and technical uncertainty. Regarding the technology uncertainty: product-developing firms are more often then not unfamiliar with fuel cell technology technology. Yet there is a high interface complexity between the technology supplied and the product in which it is to be incorporated. In this paper the information exchange in three current fuel cell product development projects is analysed to determine the information required by a product designer to develop a fuel cell product. Technology transfer literature suggests that transfer effectiveness is greatest when the type of technology (technology uncertainty) and the type of relationship between the technology supplier and the recipient are carefully matched. In this line of thinking this paper proposes that the information required by a designer, determined by the design strategy and product/system volume, should be met by an appropriate level of communication interactivity with a technology specialist. (author)

  6. Megasporogenesis and programmed cell death in Tillandsia (Bromeliaceae).

    Science.gov (United States)

    Papini, Alessio; Mosti, Stefano; Milocani, Eva; Tani, Gabriele; Di Falco, Pietro; Brighigna, Luigi

    2011-10-01

    The degeneration of three of four meiotic products is a very common process in the female gender of oogamous eukaryotes. In Tillandsia (and many other angiosperms), the surviving megaspore has a callose-free wall in chalazal position while the other three megaspores are completely embedded in callose. Therefore, nutrients and signals can reach more easily the functional megaspore from the nucellus through the chalazal pole with respect to the other megaspores. The abortion of three of four megaspores was already recognized as the result of a programmed cell death (PCD) process. We investigated the process to understand the modality of this specific type of PCD and its relationship to the asymmetric callose deposition around the tetrad. The decision on which of the four megaspores will be the supernumerary megaspores in angiosperms, and hence destined to undergo programmed cell death, appears to be linked to the callose layer deposition around the tetrad. During supernumerary megaspores degeneration, events leading to the deletion of the cells do not appear to belong to a single type of cell death. The first morphological signs are typical of autophagy, including the formation of autophagosomes. The TUNEL positivity and a change in morphology of mitochondria and chloroplasts indicate the passage to an apoptotic-like PCD phase, while the cellular remnants undergo a final process resembling at least partially (ER swelling) necrotic morphological syndromes, eventually leading to a mainly lipidic cell corpse still separated from the functional megaspore by a callose layer.

  7. Programmed cell death in plants: A chloroplastic connection.

    Science.gov (United States)

    Ambastha, Vivek; Tripathy, Baishnab C; Tiwari, Budhi Sagar

    2015-01-01

    Programmed cell death (PCD) is an integral cellular program by which targeted cells culminate to demise under certain developmental and pathological conditions. It is essential for controlling cell number, removing unwanted diseased or damaged cells and maintaining the cellular homeostasis. The details of PCD process has been very well elucidated and characterized in animals but similar understanding of the process in plants has not been achieved rather the field is still in its infancy that sees some sporadic reports every now and then. The plants have 2 energy generating sub-cellular organelles- mitochondria and chloroplasts unlike animals that just have mitochondria. The presence of chloroplast as an additional energy transducing and ROS generating compartment in a plant cell inclines to advocate the involvement of chloroplasts in PCD execution process. As chloroplasts are supposed to be progenies of unicellular photosynthetic organisms that evolved as a result of endosymbiosis, the possibility of retaining some of the components involved in bacterial PCD by chloroplasts cannot be ruled out. Despite several excellent reviews on PCD in plants, there is a void on an update of information at a place on the regulation of PCD by chloroplast. This review has been written to provide an update on the information supporting the involvement of chloroplast in PCD process and the possible future course of the field.

  8. An application programming interface for CellNetAnalyzer.

    Science.gov (United States)

    Klamt, Steffen; von Kamp, Axel

    2011-08-01

    CellNetAnalyzer (CNA) is a MATLAB toolbox providing computational methods for studying structure and function of metabolic and cellular signaling networks. In order to allow non-experts to use these methods easily, CNA provides GUI-based interactive network maps as a means of parameter input and result visualization. However, with the availability of high-throughput data, there is a need to make CNA's functionality also accessible in batch mode for automatic data processing. Furthermore, as some algorithms of CNA are of general relevance for network analysis it would be desirable if they could be called as sub-routines by other applications. For this purpose, we developed an API (application programming interface) for CNA allowing users (i) to access the content of network models in CNA, (ii) to use CNA's network analysis capabilities independent of the GUI, and (iii) to interact with the GUI to facilitate the development of graphical plugins. Here we describe the organization of network projects in CNA and the application of the new API functions to these projects. This includes the creation of network projects from scratch, loading and saving of projects and scenarios, and the application of the actual analysis methods. Furthermore, API functions for the import/export of metabolic models in SBML format and for accessing the GUI are described. Lastly, two example applications demonstrate the use and versatile applicability of CNA's API. CNA is freely available for academic use and can be downloaded from http://www.mpi-magdeburg.mpg.de/projects/cna/cna.html. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  9. Radar Location Equipment Development Program: Phase I

    International Nuclear Information System (INIS)

    Sandness, G.A.; Davis, K.C.

    1985-06-01

    The work described in this report represents the first phase of a planned three-phase project designed to develop a radar system for monitoring waste canisters stored in a thick layer of bedded salt at the Waste Isolation Pilot Plant near Carlsbad, New Mexico. The canisters will be contained in holes drilled into the floor of the underground waste storage facility. It is hoped that these measurements can be made to accuracies of +-5 cm and +-2 0 , respectively. The initial phase of this project was primarily a feasibility study. Its principal objective was to evaluate the potential effectiveness of the radar method in the planned canister monitoring application. Its scope included an investigation of the characteristics of radar signals backscattered from waste canisters, a test of preliminary data analysis methods, an assessment of the effects of salt and bentonite (a proposed backfill material) on the propagation of the radar signals, and a review of current ground-penetrating radar technology. A laboratory experiment was performed in which radar signals were backscattered from simulated waste canisters. The radar data were recorded by a digital data acquisition system and were subsequently analyzed by three different computer-based methods to extract estimates of canister location and tilt. Each of these methods yielded results that were accurate within a few centimeters in canister location and within 1 0 in canister tilt. Measurements were also made to determine the signal propagation velocities in salt and bentonite (actually a bentonite/sand mixture) and to estimate the signal attenuation rate in the bentonite. Finally, a product survey and a literature search were made to identify available ground-penetrating radar systems and alternative antenna designs that may be particularly suitable for this unique application. 10 refs., 21 figs., 4 tabs

  10. Radar Location Equipment Development Program: Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Sandness, G.A.; Davis, K.C.

    1985-06-01

    The work described in this report represents the first phase of a planned three-phase project designed to develop a radar system for monitoring waste canisters stored in a thick layer of bedded salt at the Waste Isolation Pilot Plant near Carlsbad, New Mexico. The canisters will be contained in holes drilled into the floor of the underground waste storage facility. It is hoped that these measurements can be made to accuracies of +-5 cm and +-2/sup 0/, respectively. The initial phase of this project was primarily a feasibility study. Its principal objective was to evaluate the potential effectiveness of the radar method in the planned canister monitoring application. Its scope included an investigation of the characteristics of radar signals backscattered from waste canisters, a test of preliminary data analysis methods, an assessment of the effects of salt and bentonite (a proposed backfill material) on the propagation of the radar signals, and a review of current ground-penetrating radar technology. A laboratory experiment was performed in which radar signals were backscattered from simulated waste canisters. The radar data were recorded by a digital data acquisition system and were subsequently analyzed by three different computer-based methods to extract estimates of canister location and tilt. Each of these methods yielded results that were accurate within a few centimeters in canister location and within 1/sup 0/ in canister tilt. Measurements were also made to determine the signal propagation velocities in salt and bentonite (actually a bentonite/sand mixture) and to estimate the signal attenuation rate in the bentonite. Finally, a product survey and a literature search were made to identify available ground-penetrating radar systems and alternative antenna designs that may be particularly suitable for this unique application. 10 refs., 21 figs., 4 tabs.

  11. Development of an Android mobile application in Kotlin programming language

    OpenAIRE

    Lanišnik , Domen

    2018-01-01

    Kotlin is a modern programming language that tries to address some of the drawbacks of Java, while keeping all the advantages of Java. It promises concise and functional code with new concepts for easier implementation of common structures. Kotlin's popularity is growing fast, especially in the development of Android mobile applications, where the latest versions of Java are not supported. The goal of this thesis was to present Kotlin programming language and use it practically in the develop...

  12. Developments in the electron gun simulation program, EGUN

    International Nuclear Information System (INIS)

    Herrmannsfeldt, W.B.

    1995-01-01

    This paper discusses the developments in the electron gun simulation programs that are based on EGUN with its derivatives and supporting programs. Much of the code development has been inspired by technology changes in computer hardware; the implications of this evolution on EGN2 are discussed. Some examples and a review of the capabilities of the EGUN family are described. copyright 1995 American Institute of Physics

  13. Development of a probabilistic integrity assessment program for pipes

    International Nuclear Information System (INIS)

    Park, Jai Hak; Lee, Jae Bong; Choi, Young Hwan

    2009-01-01

    A probabilistic integrity assessment program of pipes in nuclear power plants is developed. The program is named by P-PIE (Piping Probabilistic Integrity Evaluation) and based on existing PRAISE program. Using the program, the probabilities of leakage, big leak and fracture of pipes in nuclear power plants can be obtained. Preexisting cracks and initiated crack during the operation due the stress corrosion can be considered and growth of cracks due to Stress Corrosion Cracking (SCC) and fatigue can be simulated. Operating stresses, thermal stresses, residual stresses and varying operation conditions can be considered in the program. Crack growth simulation is performed based on stress intensity factors and fracture is determined based on J integral or net section yielding. In order to check the accuracy of the program several example problems are solved and compared with the results from PRAISE. And the effects of several variables on the leak or failure probability are examined.

  14. MCPIP1 contributes to clear cell renal cell carcinomas development.

    Science.gov (United States)

    Ligeza, Janusz; Marona, Paulina; Gach, Natalia; Lipert, Barbara; Miekus, Katarzyna; Wilk, Waclaw; Jaszczynski, Janusz; Stelmach, Andrzej; Loboda, Agnieszka; Dulak, Jozef; Branicki, Wojciech; Rys, Janusz; Jura, Jolanta

    2017-08-01

    Monocyte Chemoattractant protein-induced protein 1 (MCPIP1), also known as Regnase-1, is encoded by the ZC3H12a gene, and it mediates inflammatory processes by regulating the stability of transcripts coding for proinflammatory cytokines and controlling activity of transcription factors, such as NF-κB and AP1. We found that MCPIP1 transcript and protein levels are strongly downregulated in clear cell renal cell carcinoma (ccRCC) samples, which were derived from patients surgically treated for renal cancer compared to surrounded normal tissues. Using Caki-1 cells as a model, we analyzed the role of MCPIP1 in cancer development. We showed that MCPIP1 expression depends on the proteasome activity; however, hypoxia and hypoxia inducible factor 2 alfa (HIF2α) are key factors lowering MCPIP1 expression. Furthermore, we found that MCPIP1 negatively regulates HIF1α and HIF2α levels and in the case of the last one, the mechanism is based on the regulation of the half time of transcript coding for HIF2α. Enhanced expression of MCPIP1 in Caki-1 cells results in a downregulation of transcripts encoding VEGFA, GLUT1, and IL-6. Furthermore, MCPIP1 decreases the activity of mTOR and protein kinase B (Akt) in normoxic conditions. Taken together, MCPIP1 contributes to the ccRCC development.

  15. Using online program development to foster curricular change and innovation.

    Science.gov (United States)

    Gwozdek, Anne E; Springfield, Emily C; Peet, Melissa R; Kerschbaum, Wendy E

    2011-03-01

    Distance education offers an opportunity to catalyze sweeping curricular change. Faculty members of the University of Michigan Dental Hygiene Program spent eighteen months researching best practices, planning outcomes and courses, and implementing an e-learning (online) dental hygiene degree completion program. The result is a collaborative and portfolio-integrated program that focuses on the development of reflective practitioners and leaders in the profession. A team-based, systems-oriented model for production, implementation, and evaluation has been critical to the program's success. The models and best practices on which this program was founded are described. Also provided is a framework of strategies for development, including the utilization of backward course design, which can be used in many areas of professional education.

  16. Development of Performance Demonstration Programs for Eddy Current Data Analysis

    International Nuclear Information System (INIS)

    Cho, Chan Hee; Nam, Min Woo; Yang, Seung Han; Yang, Dong Soon; Lee, Hee Jong

    2005-01-01

    The Korea Electric Power Research Institute (KEPRI) has developed performance demonstration programs for non-destructive testing personnel who analyze ECT(eddy current testing) data for steam generator tubing since 2001. The purpose of these performance demonstration programs is to ensure a uniform knowledge and skill level of data analysts and contribute to safe operation of nuclear power plants. Many changes have occurred in non-destructive testing of steam generator tubing such as inspection scope, plugging criteria and qualification requirements. According to the Notice 2004-13 revised by the Ministry of Science and Technology (MOST), the analyst for steam generator tubing shall be qualified as the qualified data analyst (QDA), and the site specific performance demonstration (SSPD) program shall be implemented. KEPRI developed these performance demonstration programs and they are being successfully implemented. The analyst's performance is expected to be improved by the implementation of these programs

  17. Nitric oxide and hydrogen peroxide involvement during programmed cell death of Sechium edule nucellus.

    Science.gov (United States)

    Lombardi, Lara; Ceccarelli, Nello; Picciarelli, Piero; Sorce, Carlo; Lorenzi, Roberto

    2010-09-01

    The nucellus is a maternal tissue that feeds the developing embryo and the secondary endosperm. During seed development the cells of the nucellus suffer a degenerative process early after fertilization as the cellular endosperm expands and accumulates reserves. Nucellar cell degeneration has been characterized as a form of developmentally programmed cell death (PCD). In this work we show that nucellus PCD is accompanied by a considerable production of both nitric oxide and hydrogen peroxide (NO and H(2)O(2)). Interestingly, each of the two molecules is able to induce the production of the other and to cause cell death when applied to a living nucellus. We show that the induced cell death has features of a PCD, accompanied by profound changes in the morphology of the nuclei and by a massive degradation of nuclear DNA. Moreover, we report that NO and H(2)O(2) cause an induction of caspase-like proteases previously characterized in physiological nucellar PCD.

  18. Improved premises for cell factory development

    DEFF Research Database (Denmark)

    Søgaard, Karina Marie

    by a differential expression of the lysozyme gene encoded on the same plasmid. These phenomena seem to have been largely overlooked despite the huge popularity of the T7/pet-based systems for bacterial protein production. Additionally, the paradox that standardization comes at the cost of reduced flexibility...... is at the core of biotechnology and numerous molecular tools and bacterial strains have been developed over the past four decades for this purpose. Understanding of the genetic code and our ability to manipulate genetic material, paves the way for the microbial cell factory development that enables production...... of protein in a sustainable, costefficient manner. In this thesis I report the joined efforts of my colleagues and myself, to improve the premises for cell factory development by optimizing the cloning strategies, improving the awareness of unforeseen side-effects in complex bacterial expression systems...

  19. Plant programmed cell death from a chromatin point of view.

    Science.gov (United States)

    Latrasse, D; Benhamed, M; Bergounioux, C; Raynaud, C; Delarue, M

    2016-10-01

    Programmed cell death (PCD) is a ubiquitous genetically regulated process consisting of the activation of finely controlled signalling pathways that lead to cellular suicide. PCD can be part of a developmental programme (dPCD) or be triggered by environmental conditions (ePCD). In plant cells, as in animal cells, extensive chromatin condensation and degradation of the nuclear DNA are among the most conspicuous features of cells undergoing PCD. Changes in chromatin condensation could either reflect the structural changes required for internucleosomal fragmentation of nuclear DNA or relate to large-scale chromatin rearrangements associated with a major transcriptional switch occurring during cell death. The aim of this review is to give an update on plant PCD processes from a chromatin point of view. The first part will be dedicated to chromatin conformational changes associated with cell death observed in various developmental and physiological conditions, whereas the second part will be devoted to histone dynamics and DNA modifications associated with critical changes in genome expression during the cell death process. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  20. Training program developed for senior undergraduates majoring in optical communication

    Science.gov (United States)

    Cui, Sheng; Zhang, Xinliang; Ke, Changjian

    2017-08-01

    Based on the well-known simulation software VPI TransmissionMaker, a comprehensive training program for senior undergraduates majoring in optical communication and optical network technology was developed by the author after detailed study of the teaching difficult and key points in the discipline. Aiming at solving practical scientific and engineering problems, the program helped our students to develop the ability of acquiring and applying knowledge by designing optical devices, optical signal processing algorithms and optical fiber communication systems. Furthermore, innovation is inspired by introducing competition mechanism among project teams. The program was validated through four years of use and achieved good results.

  1. Student Expectations from Participating in a Small Spacecraft Development Program

    Directory of Open Access Journals (Sweden)

    Jeremy Straub

    2013-11-01

    Full Text Available The number of small spacecraft development programs in the United States and worldwide have increased significantly over the course of the last 10 years. This paper analyzes reasons for the growth in these programs by assessing what student participants hope to gain from their participation. Participants in the OpenOrbiter Small Spacecraft Development Initiative at the University of North Dakota were surveyed at the beginning of an academic year to determine why they were planning to participate in the program again or join and participate for the first time. This paper presents the results of this survey.

  2. Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program.

    Science.gov (United States)

    Khacho, Mireille; Clark, Alysen; Svoboda, Devon S; Azzi, Joelle; MacLaurin, Jason G; Meghaizel, Cynthia; Sesaki, Hiromi; Lagace, Diane C; Germain, Marc; Harper, Mary-Ellen; Park, David S; Slack, Ruth S

    2016-08-04

    Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion and aging. While mitochondrial morphology plays a fundamental role in tissue development and homeostasis, its role in stem cells remains unknown. Here, we uncover that mitochondrial dynamics regulates stem cell identity, self-renewal, and fate decisions by orchestrating a transcriptional program. Manipulation of mitochondrial structure, through OPA1 or MFN1/2 deletion, impaired neural stem cell (NSC) self-renewal, with consequent age-dependent depletion, neurogenesis defects, and cognitive impairments. Gene expression profiling revealed ectopic expression of the Notch self-renewal inhibitor Botch and premature induction of transcription factors that promote differentiation. Changes in mitochondrial dynamics regulate stem cell fate decisions by driving a physiological reactive oxygen species (ROS)-mediated process, which triggers a dual program to suppress self-renewal and promote differentiation via NRF2-mediated retrograde signaling. These findings reveal mitochondrial dynamics as an upstream regulator of essential mechanisms governing stem cell self-renewal and fate decisions through transcriptional programming. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Using microfluidics to study programmed cell death: A new approach

    DEFF Research Database (Denmark)

    Mark, Christina; Zor, Kinga; Heiskanen, Arto

    This project focuses on applying microfluidic tissue culture for electrochemical or optical measurements during programmed cell death (PCD) in barley aleurone layer to increase understanding of the underlying mechanisms of PCD in plants. Microfluidic tissue culture enables in vitro experiments...... a double-fluorescent probe-system also used by Fath et al5. Future challenges include integrating both these systems into a microfluidic device for plant tissue culture....

  4. Internet and cell phone based smoking cessation programs among adolescents

    OpenAIRE

    Purvi Mehta,; Manoj Sharma

    2010-01-01

    Smoking cessation among adolescents is a salient public health issue, as it can preventthe adoption of risky health behaviors and reduce negative impacts on health. Self-efficacy,household and social support systems, and perceived benefits are some important cessationdeterminants. With the popular use of the Internet and cell phone usage among adolescents,smoking cessation programs are beginning to adopt these new delivery methods. The purpose ofthe study is to review interventions between 20...

  5. Development of Effective Teacher Program: Teamwork Building Program for Thailand's Municipal Schools

    Science.gov (United States)

    Chantathai, Pimpka; Tesaputa, Kowat; Somprach, Kanokorn

    2015-01-01

    This research is aimed to formulate the effective teacher teamwork program in municipal schools in Thailand. Primary survey on current situation and problem was conducted to develop the plan to suggest potential programs. Samples were randomly selected from municipal schools by using multi-stage sampling method in order to investigate their…

  6. Recent developments in blood cell labeling research

    International Nuclear Information System (INIS)

    Srivastava, S.C.; Straub, R.F.; Meinken, G.E.

    1988-01-01

    A number of recent developments in research on blood cell labeling techniques are presented. The discussion relates to three specific areas: (1) a new in vitro method for red blood cell labeling with /sup 99m/Tc; (2) a method for labeling leukocytes and platelets with /sup 99m/Tc; and (3) the use of monoclonal antibody technique for platelet labeling. The advantages and the pitfalls of these techniques are examined in the light of available mechanistic information. Problems that remain to be resolved are reviewed. An assessment is made of the progress as well as prospects in blood cell labeling methodology including that using the monoclonal antibody approach. 37 refs., 4 figs

  7. Cells, embryos and development in space

    Science.gov (United States)

    Krikorian, A. D.

    1984-01-01

    Work continues to focus on the demonstrable totipotency of cultured somatic cells of various higher plants and has examined the conditions which regulate this propensity to be controllably released. This was done with special reference to cells obtained from cultured explants of daylily and carrot. For purposes of identifying the variables in question, work was carried out almost exclusively in liquid media. The events that intervene between the aseptic isolation of tissue explants, the culture of small derived units and free cells and the propagation in large numbers of adventive or somatic embryos to plantlets were traced and certain definitive stages at which control is exercised were identified. In daylily, morphologically competent units are now propagated with a high degree of precision in rotated liquid cultures in bulk, and under the conditions of continuous neutralized gravity, the development progresses so that embryo-plantlets are obtained.

  8. Recent developments in blood cell labeling research

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, S.C.; Straub, R.F.; Meinken, G.E.

    1988-09-07

    A number of recent developments in research on blood cell labeling techniques are presented. The discussion relates to three specific areas: (1) a new in vitro method for red blood cell labeling with /sup 99m/Tc; (2) a method for labeling leukocytes and platelets with /sup 99m/Tc; and (3) the use of monoclonal antibody technique for platelet labeling. The advantages and the pitfalls of these techniques are examined in the light of available mechanistic information. Problems that remain to be resolved are reviewed. An assessment is made of the progress as well as prospects in blood cell labeling methodology including that using the monoclonal antibody approach. 37 refs., 4 figs.

  9. Herceptin conjugates linked by EDC boost direct tumor cell death via programmed tumor cell necrosis.

    Directory of Open Access Journals (Sweden)

    Jiemiao Hu

    Full Text Available Tumor-targeted antibody therapy is one of the safest biological therapeutics for cancer patients, but it is often ineffective at inducing direct tumor cell death and is ineffective against resistant tumor cells. Currently, the antitumor efficacy of antibody therapy is primarily achieved by inducing indirect tumor cell death, such as antibody-dependent cell cytotoxicity. Our study reveals that Herceptin conjugates, if generated via the crosslinker EDC (1-ethyl-3-(3-dimethylaminopropyl carbodiimide hydrochloride, are capable of engendering human epidermal growth factor receptor 2 (Her2 positive tumor cells death. Using a high-performance liquid chromatography (HPLC system, three peaks with estimated molecular weights of antibody monomer, dimer, and trimer were isolated. Both Herceptin trimer and dimer separated by HPLC induced significant levels of necrotic tumor cell death, although the trimer was more effective than the dimer. Notably, the Herceptin trimer also induced Herceptin-resistant tumor cell death. Surprisingly different from the known cell death mechanism that often results from antibody treatment, the Herceptin trimer elicited effective and direct tumor cell death via a novel mechanism: programmed cell necrosis. In Her2-positive cells, inhibition of necrosis pathways significantly reversed Herceptin trimer-induced cell death. In summary, the Herceptin trimer reported herein harbors great potential for overcoming tumor cell resistance to Herceptin treatment.

  10. THE VIEWS OF FOREST OUTSKIRT COMMUNITY ON AGROFORESTRY DEVELOPMENT PROGRAM

    Directory of Open Access Journals (Sweden)

    Dewa Oka Suparwata

    2018-04-01

    Full Text Available Nowadays, development of agroforestry has been focused on the people living near forest. Positive views from community may have a good impact on agroforestry development program. This research aims to study the views of the forest outskrit community on the agroforestry development program in Dulamayo Barat village, Telaga Sub District, Gorontalo Regency, Gorontalo Province. The study used survey approach and focus group discussion (FGD method. Respondents were all the members of agroforestry farmer group. The entire population were taken for interview (10 respondents while FGD was attended by 26 participants. Data were analyzed descriptively. The result showed that 100% of the respondents want the program to be sustainable, although from the socio economic point of view the impact has not contributed significantly. From the respondents views of its benefit, 50% believe that the program is for critical land rehabilitation, 30% have a view for the improvement of environmental service, 10% view to increase community economy, and 10% view that the program is to eliminate erosion. These indicate that the community is concerned with agroforestry development, therefore, continuous facilitation is needed. Furthermore, the community expects to be actively involved in the agroforestry development program.

  11. Coordinated irradiation plan for the Fuel Refabrication and Development Program

    International Nuclear Information System (INIS)

    Barner, J.O.

    1979-04-01

    The Department of Energy's Fuel Refabrication and Development (FRAD) Program is developing a number of proliferation-resistant fuel systems and forms for alternative use in nuclear reactors. A major portion of the program is the development of irradiation behavioral information for the fuel system/forms with the ultimate objective of qualifying the design for licensing and commercial utilization. The nuclear fuel systems under development include denatured thoria--urania fuels and spiked urania--plutonia or thoria--plutonia fuels. The fuel forms being considered include pellet fuel produced from mechanically mixed or coprecipitated feed materials, pellet fuel fabricated from partially calcined gel-derived or freeze-dried spheres (hybrid fuel) and packed-particle fuel produced from sintered gel-derived spheres (sphere-pac). This document describes the coordinated development program that will be used to test and demonstrate the irradiation performance of alternative fuels

  12. Graphical programming interface: A development environment for MRI methods.

    Science.gov (United States)

    Zwart, Nicholas R; Pipe, James G

    2015-11-01

    To introduce a multiplatform, Python language-based, development environment called graphical programming interface for prototyping MRI techniques. The interface allows developers to interact with their scientific algorithm prototypes visually in an event-driven environment making tasks such as parameterization, algorithm testing, data manipulation, and visualization an integrated part of the work-flow. Algorithm developers extend the built-in functionality through simple code interfaces designed to facilitate rapid implementation. This article shows several examples of algorithms developed in graphical programming interface including the non-Cartesian MR reconstruction algorithms for PROPELLER and spiral as well as spin simulation and trajectory visualization of a FLORET example. The graphical programming interface framework is shown to be a versatile prototyping environment for developing numeric algorithms used in the latest MR techniques. © 2014 Wiley Periodicals, Inc.

  13. The DOE safeguards and security technology development program

    International Nuclear Information System (INIS)

    Cherry, R.C.; Wheelock, A.J.

    1991-01-01

    This paper reports that strategic planning for safeguards and security within the Department of Energy emphasizes the contributions of advanced technologies to the achievement of Departmental protection program goals. The Safeguards and Security Technology Development Program provides state-of-the-art technologies, systems and technical services in support of the policies and programmatic requirements for the protection of Departmental assets. The Program encompasses research and development in physical security, nuclear material control and accountability, information security and personnel security, and the integration of these disciplines in advanced applications. Technology development tasks serve goals that range from the maintenance of an effective technology base to the development, testing and evaluation of applications to meet field needs. A variety of factors, from the evolving threat to reconfiguration of the DOE complex and the technical requirements of new facilities, are expected to influence safeguards and security technology requirements and development efforts. Implementation of the Program is based on the systematic identification, prioritization and alignment of technology development tasks and needs. Initiatives currently underway are aimed at enhancing technology development project management. Increased management attention is also being placed on efforts to promote the benefits of the Program through technology transfer and interagency liaison

  14. ESTIMATING FINANCIAL SUPPORT OF REGIONAL PROGRAMS OF SOCIAL ECONOMIC DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Iryna Kokhan

    2016-03-01

    Full Text Available The given article presents the analysis of the experience of the financial support of the regional programs of social economic development and the areas of usage of internal and external resources of the area. Dynamic and balanced development of regions is one of the most important issues for further establishment of marketing relations and social transformations in Ukraine. The Aim lies in the evaluation of financial support of the approved regional programs and launching the amount of their financing. The assessment of social economic situation in Ivano-Frankivsk region in terms of nationwide tendencies allows asserting that economic growth depends on the amounts and sources provided by the state. To determine close connection between  the amount of financing  for the programs  and  gross domestic product, the coefficient of correlation was calculated according to Pierson. It was proved that the amount of financing regional programs of social economic development influences the growth rate of gross domestic product. During research period the activation of regional authority institutions is being surveyed regarding the adoption and financing target regional programs. It was determined that the dynamic activity of the regional community and its territorial units on realization in terms of defined strategic priorities for programs of social economic development will facilitate disproportion reduction and differences in the development of territory units in the region, as well as positively influences the growth of gross domestic product providing steady increase of social welfare. Keywords: social economic regional development, ecology programs, social programs, gross regional domestic product, Pierson’s correlation coefficient. JEL: R 58

  15. Development of manufacturing capability for high-concentration, high-efficiency silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Sinton, R.A.; Verlinden, P.J.; Crane, R.A.; Swanson, R.N. [SunPower Corp., Sunnyvale, CA (United States)

    1996-10-01

    This report presents a summary of the major results from a program to develop a manufacturable, high-efficiency silicon concentrator solar cell and a cost-effective manufacturing facility. The program was jointly funded by the Electric Power Research Institute, Sandia National Laboratories through the Concentrator Initiative, and SunPower Corporation. The key achievements of the program include the demonstration of 26%-efficient silicon concentrator solar cells with design-point (20 W/cm{sup 2}) efficiencies over 25%. High-performance front-surface passivations; that were developed to achieve this result were verified to be absolutely stable against degradation by 475 days of field exposure at twice the design concentration. SunPower demonstrated pilot production of more than 1500 of these cells. This cell technology was also applied to pilot production to supply 7000 17.7-cm{sup 2} one-sun cells (3500 yielded wafers) that demonstrated exceptional quality control. The average efficiency of 21.3% for these cells approaches the peak efficiency ever demonstrated for a single small laboratory cell within 2% (absolute). Extensive cost models were developed through this program and calibrated by the pilot-production project. The production levels achieved indicate that SunPower could produce 7-10 MW of concentrator cells per year in the current facility based upon the cell performance demonstrated during the program.

  16. Statins and voriconazole induce programmed cell death in Acanthamoeba castellanii.

    Science.gov (United States)

    Martín-Navarro, Carmen M; López-Arencibia, Atteneri; Sifaoui, Ines; Reyes-Batlle, María; Valladares, Basilio; Martínez-Carretero, Enrique; Piñero, José E; Maciver, Sutherland K; Lorenzo-Morales, Jacob

    2015-05-01

    Members of the genus Acanthamoeba are facultative pathogens of humans, causing a sight-threatening keratitis and a life-threatening encephalitis. In order to treat those infections properly, it is necessary to target the treatment not only to the trophozoite but also to the cyst. Furthermore, it may be advantageous to avoid parasite killing by necrosis, which may induce local inflammation. We must also avoid toxicity of host tissue. Many drugs which target eukaryotes are known to induce programmed cell death (PCD), but this process is poorly characterized in Acanthamoeba. Here, we study the processes of programmed cell death in Acanthamoeba, induced by several drugs, such as statins and voriconazole. We tested atorvastatin, fluvastatin, simvastatin, and voriconazole at the 50% inhibitory concentrations (IC50s) and IC90s that we have previously established. In order to evaluate this phenomenon, we investigated the DNA fragmentation, one of the main characteristics of PCD, with quantitative and qualitative techniques. Also, the changes related to phosphatidylserine exposure on the external cell membrane and cell permeability were studied. Finally, because caspases are key to PCD pathways, caspase activity was evaluated in Acanthamoeba. All the drugs assayed in this study induced PCD in Acanthamoeba. To the best of our knowledge, this is the first study where PCD induced by drugs is described quantitatively and qualitatively in Acanthamoeba. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  17. Prolonged antigen presentation by immune complex–binding dendritic cells programs the proliferative capacity of memory CD8 T cells

    Science.gov (United States)

    León, Beatriz; Ballesteros-Tato, André; Randall, Troy D.

    2014-01-01

    The commitment of naive CD8 T cells to effector or memory cell fates can occur after a single day of antigenic stimulation even though virus-derived antigens (Ags) are still presented by DCs long after acute infection is resolved. However, the effects of extended Ag presentation on CD8 T cells are undefined and the mechanisms that regulate prolonged Ag presentation are unknown. We showed that the sustained presentation of two different epitopes from influenza virus by DCs prevented the premature contraction of the primary virus-specific CD8 T cell response. Although prolonged Ag presentation did not alter the number of memory CD8 T cells that developed, it was essential for programming the capacity of these cells to proliferate, produce cytokines, and protect the host after secondary challenge. Importantly, prolonged Ag presentation by DCs was dependent on virus-specific, isotype-switched antibodies (Abs) that facilitated the capture and cross-presentation of viral Ags by FcγR-expressing DCs. Collectively, our results demonstrate that B cells and Abs can regulate the quality and functionality of a subset of antiviral CD8 T cell memory responses and do so by promoting sustained Ag presentation by DCs during the contraction phase of the primary T cell response. PMID:25002751

  18. Canadian CANDU fuel development program and recent fuel operating experience

    International Nuclear Information System (INIS)

    Lau, J.H.K.; Inch, W.W.R.; Cox, D.S.; Steed, R.G.; Kohn, E.; Macici, N.N.

    1999-01-01

    This paper reviews the performance of the CANDU fuel in the Canadian CANDU reactors in 1997 and 1998. The operating experience demonstrates that the CANDU fuel has performed very well. Over the 2-year period, the fuel-bundle defect rate for all bundles irradiated in the Canadian CANDU reactors has remained very low, at between 0.006% to 0.016%. On a fuel element basis, this represents an element defect rate of less than about 0.0005%. One of the reasons for the good fuel performance is the support provided by the Canadian fuel research and development programs. These programs address operational issues and provide evolutionary improvements to the fuel products. The programs consist of the Fuel Technology Program, funded by the CANDU Owners Group, and the Advanced Fuel and Fuel Cycles Technology Program, funded by Atomic Energy of Canada Ltd. These 2 programs, which have been in place for many years, complement each other by sharing expert resources and experimental facilities. This paper describes the programs in 1999/2000, to provide an overview of the scope of the programs and the issues that these programs address. (author)

  19. INSTRUMENTAL TOOLS FOR PROGRAM CODE DEVELOPMENT WRITTEN IN HIGH LEVEL PROGRAMMING LANGUAGE.

    Directory of Open Access Journals (Sweden)

    E.A. Alferov

    2010-11-01

    Full Text Available The paper presents the environment of demonstration of integrated environment for studying course «Basics of algorithmization and programming» (http://weboap.ksu.ks.ua, which allows execution of computational experiment to study the complexity and majorizability of sorting algorithms. We describe the design and development of new version of the application. Much attention is paid to the development component of the code editor, which will meet the current requirements of tools to write programs.

  20. Leadership development programs for physicians: a systematic review.

    Science.gov (United States)

    Frich, Jan C; Brewster, Amanda L; Cherlin, Emily J; Bradley, Elizabeth H

    2015-05-01

    Physician leadership development programs typically aim to strengthen physicians' leadership competencies and improve organizational performance. We conducted a systematic review of medical literature on physician leadership development programs in order to characterize the setting, educational content, teaching methods, and learning outcomes achieved. Articles were identified through a search in Ovid MEDLINE from 1950 through November 2013. We included articles that described programs designed to expose physicians to leadership concepts, outlined teaching methods, and reported evaluation outcomes. A thematic analysis was conducted using a structured data entry form with categories for setting/target group, educational content, format, type of evaluation and outcomes. We identified 45 studies that met eligibility criteria, of which 35 reported on programs exclusively targeting physicians. The majority of programs focused on skills training and technical and conceptual knowledge, while fewer programs focused on personal growth and awareness. Half of the studies used pre/post intervention designs, and four studies used a comparison group. Positive outcomes were reported in all studies, although the majority of studies relied on learner satisfaction scores and self-assessed knowledge or behavioral change. Only six studies documented favorable organizational outcomes, such as improvement in quality indicators for disease management. The leadership programs examined in these studies were characterized by the use of multiple learning methods, including lectures, seminars, group work, and action learning projects in multidisciplinary teams. Physician leadership development programs are associated with increased self-assessed knowledge and expertise; however, few studies have examined outcomes at a system level. Our synthesis of the literature suggests important gaps, including a lack of programs that integrate non-physician and physician professionals, limited use of more

  1. Early growth response gene-2 (Egr-2 regulates the development of B and T cells.

    Directory of Open Access Journals (Sweden)

    Suling Li

    2011-04-01

    Full Text Available Understanding of how transcription factors are involved in lymphocyte development still remains a challenge. It has been shown that Egr-2 deficiency results in impaired NKT cell development and defective positive selection of T cells. Here we investigated the development of T, B and NKT cells in Egr-2 transgenic mice and the roles in the regulation of distinct stages of B and T cell development.The expression of Egr1, 2 and 3 were analysed at different stages of T and B cell development by RT-PCT and results showed that the expression was strictly regulated at different stages. Forced expression of Egr-2 in CD2(+ lymphocytes resulted in a severe reduction of CD4(+CD8(+ (DP cells in thymus and pro-B cells in bone marrow, which was associated with reduced expression of Notch1 in ISP thymocytes and Pax5 in pro-B cells, suggesting that retraction of Egr-2 at the ISP and pro-B cell stages is important for the activation of lineage differentiation programs. In contrast to reduction of DP and pro-B cells, Egr-2 enhanced the maturation of DP cells into single positive (SP T and NKT cells in thymus, and immature B cells into mature B cells in bone marrow.Our results demonstrate that Egr-2 expressed in restricted stages of lymphocyte development plays a dynamic, but similar role for the development of T, NKT and B cells.

  2. Programming cell fate on bio-functionalized silicon.

    Science.gov (United States)

    Premnath, Priyatha; Tan, Bo; Venkatakrishnan, Krishnan

    2015-04-01

    Controlling the growth of cells on the surface of silicon without an additive layer or topographical modification is unexplored. This research article delineates the discovery of unique properties of a bio-functionalized silicon substrate, programmed to repel or control cells, generated by ultrafast femtosecond pulse interaction with silicon. Remarkably, bio-functionalization in any shape or size without change in topology or morphology is observed indicating only sub-surface phase transformations. Material characterization reveals the presence of a unique mixture of phases of SiO2 and Si. Consequently, these variations in phase alter the physicochemical characteristics on the surface of silicon resulting in its bio-functionalization. The culture of mouse embryonic fibroblasts shows unique adhesion characteristics on these bio-functionalized silicon surfaces that include cell controlling, cell trapping, and cell shaping. Furthermore, the directionality of fibroblasts is restrained parallel to bio-functionalized zones as evidenced by changes in cytoskeleton. The controlling of proliferation, migration and adhesion of cells is attributed to unique phase bio-functionalization. This method presents considerable promise in a myriad of applications such as tissue engineering, MEMS, and lab-on-a-chip devices. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Oxidative Stress and Programmed Cell Death in Yeast

    International Nuclear Information System (INIS)

    Farrugia, Gianluca; Balzan, Rena

    2012-01-01

    Yeasts, such as Saccharomyces cerevisiae, have long served as useful models for the study of oxidative stress, an event associated with cell death and severe human pathologies. This review will discuss oxidative stress in yeast, in terms of sources of reactive oxygen species (ROS), their molecular targets, and the metabolic responses elicited by cellular ROS accumulation. Responses of yeast to accumulated ROS include upregulation of antioxidants mediated by complex transcriptional changes, activation of pro-survival pathways such as mitophagy, and programmed cell death (PCD) which, apart from apoptosis, includes pathways such as autophagy and necrosis, a form of cell death long considered accidental and uncoordinated. The role of ROS in yeast aging will also be discussed.

  4. Using microfluidics to study programmed cell death: A new approach

    DEFF Research Database (Denmark)

    Mark, Christina; Zor, Kinga; Heiskanen, Arto

    This project focuses on applying microfluidic tissue culture for electrochemical or optical measurements during programmed cell death (PCD) in barley aleurone layer to increase understanding of the underlying mechanisms of PCD in plants. Microfluidic tissue culture enables in vitro experiments...... to approach in vivo conditions. Microfluidics also allow implementation of a wide range of electrochemical or optical assays for online, real-time, parallel analysis of important parameters such as redox activity, O2 and H2O2 concentration, extracellular pH, cell viability and enzyme activity1,2. Currently......, we are optimising an intracellular whole-cell redox activity assay3 that detects changes in redox activity in barley aleurone layer during PCD. The assay uses a double mediator-system to electrochemically measure redox activity via changes in the NADP:NADPH ratio. Initial experiments assay show...

  5. Saving our future: James Comer and the School Development Program.

    Science.gov (United States)

    Panjwani, Naaila

    2011-06-01

    Since the founding of the School Development Program (SDP) by Dr. James Comer in 1968, the manner in which child development is addressed in many schools has changed drastically. By working together using the SDP model, schools, parents, and child development experts are able to foster healthy social, emotional, and academic development in children, resulting in improvement in all areas. This review briefly describes the creation and implementation of the SDP model by Dr. James Comer.

  6. Stepwise development of hematopoietic stem cells from embryonic stem cells.

    Directory of Open Access Journals (Sweden)

    Kenji Matsumoto

    Full Text Available The cellular ontogeny of hematopoietic stem cells (HSCs remains poorly understood because their isolation from and their identification in early developing small embryos are difficult. We attempted to dissect early developmental stages of HSCs using an in vitro mouse embryonic stem cell (ESC differentiation system combined with inducible HOXB4 expression. Here we report the identification of pre-HSCs and an embryonic type of HSCs (embryonic HSCs as intermediate cells between ESCs and HSCs. Both pre-HSCs and embryonic HSCs were isolated by their c-Kit(+CD41(+CD45(- phenotype. Pre-HSCs did not engraft in irradiated adult mice. After co-culture with OP9 stromal cells and conditional expression of HOXB4, pre-HSCs gave rise to embryonic HSCs capable of engraftment and long-term reconstitution in irradiated adult mice. Blast colony assays revealed that most hemangioblast activity was detected apart from the pre-HSC population, implying the early divergence of pre-HSCs from hemangioblasts. Gene expression profiling suggests that a particular set of transcripts closely associated with adult HSCs is involved in the transition of pre-HSC to embryonic HSCs. We propose an HSC developmental model in which pre-HSCs and embryonic HSCs sequentially give rise to adult types of HSCs in a stepwise manner.

  7. Programmed cell death protein-1/programmed cell death ligand-1 pathway inhibition and predictive biomarkers: understanding transforming growth factor-beta role.

    Science.gov (United States)

    Santarpia, Mariacarmela; González-Cao, María; Viteri, Santiago; Karachaliou, Niki; Altavilla, Giuseppe; Rosell, Rafael

    2015-12-01

    A deeper understanding of the key role of the immune system in regulating tumor growth and progression has led to the development of a number of immunotherapies, including cancer vaccines and immune checkpoint inhibitors. Immune checkpoint inhibitors target molecular pathways involved in immunosuppression, such as cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) pathway, with the goal to enhance the host's own immune anticancer response. In phase I-III trials, anti-PD-1/PD-L1 antibodies have demonstrated to be effective treatment strategies by inducing significant durable tumor responses, with manageable toxicities, in patients with various malignancies, including those traditionally considered non-immunogenic, such as non-small cell lung cancer (NSCLC). Identification of predictive biomarkers to select patients for immune therapies is currently being investigated to improve their therapeutic efficacy. Transforming growth factor-β (TGF-β), a pleiotropic cytokine with immunosuppressive effects on multiple cell types of the innate and adaptive immune system, has emerged as one of the potential key factors modulating response to immune checkpoint inhibitors. However, due to the complexity of the anti-cancer immune response, the predictive value of many other factors related to cancer cells or tumor microenvironment needs to be further explored.

  8. Induction of Programmed Cell Death in Human Alveolar Epithelial Cells Infected with Influenza Virus

    Directory of Open Access Journals (Sweden)

    Sh Shahsavandi

    2015-11-01

    Full Text Available Introduction: Avian influenza viruses are considered as a serious threat to human and animal health. An increase in expression of proinflammatory cytokines and type I IFN genes, as well as host cell death responses contribute to the pathogenesis of influenza infection. Hence, this study aimed to evaluate the growth dynamics of subacute avian influenza virus in human respiratory alveolar epithelium cells (A549. Methods: The A549 cell cultures were infected at MOIs 0.1 and 2.0 viral doses in the presence and absence of trypsin. The virus growth kinetics were elucidated by the plaque assay and the cell viability was determined by MTT at various times after the infection. The induction quality of programmed cell death as well as the signal transduction pathway of death were assessed by genomic DNA fragmentation and western blotting respectively. Results: The study findings indicated that although the H9N2 virus replication did produce a marked cytopathic effect on the alveolar cells, which led to a reduction in the cell viability, the viral titers were increased in the infected cells. The virus replication of in these cells indicated repression of host defense mechanism as well as activation of cell death. The induction of apoptosis in A549 cells was correlated with the increased virus titers as well as virus replication (p< 0.05. Conclusion: H9N2 avian influenza virus were demonstrated to induce apoptosis in human alveolar epithelial cells via the intrinsic pathway in a dose-dependent manner.

  9. RELAP5-3D Developer Guidelines and Programming Practices

    Energy Technology Data Exchange (ETDEWEB)

    Dr. George L Mesina

    2014-03-01

    Our ultimate goal is to create and maintain RELAP5-3D as the best software tool available to analyze nuclear power plants. This begins with writing excellent programming and requires thorough testing. This document covers development of RELAP5-3D software, the behavior of the RELAP5-3D program that must be maintained, and code testing. RELAP5-3D must perform in a manner consistent with previous code versions with backward compatibility for the sake of the users. Thus file operations, code termination, input and output must remain consistent in form and content while adding appropriate new files, input and output as new features are developed. As computer hardware, operating systems, and other software change, RELAP5-3D must adapt and maintain performance. The code must be thoroughly tested to ensure that it continues to perform robustly on the supported platforms. The coding must be written in a consistent manner that makes the program easy to read to reduce the time and cost of development, maintenance and error resolution. The programming guidelines presented her are intended to institutionalize a consistent way of writing FORTRAN code for the RELAP5-3D computer program that will minimize errors and rework. A common format and organization of program units creates a unifying look and feel to the code. This in turn increases readability and reduces time required for maintenance, development and debugging. It also aids new programmers in reading and understanding the program. Therefore, when undertaking development of the RELAP5-3D computer program, the programmer must write computer code that follows these guidelines. This set of programming guidelines creates a framework of good programming practices, such as initialization, structured programming, and vector-friendly coding. It sets out formatting rules for lines of code, such as indentation, capitalization, spacing, etc. It creates limits on program units, such as subprograms, functions, and modules. It

  10. Magnet and conductor developments for the Mirror Fusion Program

    International Nuclear Information System (INIS)

    Cornish, D.N.

    1981-01-01

    The conductor development and the magnet design and construction for the MFTF are described. Future plans for the Mirror Program and their influence on the associated superconductor development program are discussed. Included is a summary of the progress being made to develop large, high-field, multifilamentary Nb 3 Sn superconductors and the feasibility of building a 12-T yin-yang set of coils for the machine to follow MFTF. In a further look into the future, possible magnetic configurations and requirements for mirror reactors are surveyed

  11. Developing a model lifeline protection program for DOE facilities

    International Nuclear Information System (INIS)

    Lowing, A.N.

    1996-01-01

    A National Lifeline Standard Development Program is currently being conducted by FEMA and NIST. The Department of Energy is following these developments and supplementing them to meet Life-Safety and mission requirements for all DOE facilities as part of the Natural Phenomena Hazards Mitigation Plan. The task will be overseen by a DOE management team with technical guidance provided by a Steering Group of management and operating contractor representatives. The DOE will participate in the federal program by conducting a workshop on lifeline protection issues, developing an overall plan, organizing a Steering Group, and conducting a pilot study at a DOE facility

  12. Development of regulatory technical rationale for risk monitoring program

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Chang Hyun; Kim, Ju Youl; Kim, Yoon Ik; Yang, Hui Chang; Lee, Yong Suk; Ahn, Kwang Won; Kim, Se Hyung [Seoul National Univ., Seoul (Korea, Republic of)

    2002-03-15

    In Korea, the risk monitoring program will be developed and applied to each plants till 2003 by the severe accident management plan to enhance the safety functions of the nuclear power plants. Through this plan, the risk monitoring for the full power and low power and shutdown operation will be performed. Therefore the development of consistent risk monitoring system and overall regulatory guides for the risk monitoring program are necessary. The objective of this study is the development of regulatory technical rationales for the nuclear power plant risk monitoring program and the derivation of the requirements need for the development of risk monitoring system. Through this the improvement of regulatory effectiveness to assure the safe operation of nuclear power plant, is expected.

  13. Real-Time Engagement Area Development Program (Read-Pro)

    National Research Council Canada - National Science Library

    Burger, Joseph

    2002-01-01

    The Real-Tine Engagement Area Development Program (READ-Pro) is a PC-based prototype system which provides company-level commanders with real-time operational analysis tools to develop engagement areas (RA) for direct fire (DR) systems...

  14. Linking Experiences and Outcomes within a Postsecondary Leadership Development Program

    Science.gov (United States)

    Strawn, Kellie; McKim, Aaron J.; Velez, Jonathan J.

    2017-01-01

    This qualitative study explored the leadership development outcomes associated with specific experiences in a one-year, intensive leadership development program at a large northwest research university. Students highlighted three programmatic experiences for their effectiveness: (a) faculty mentoring, (b) participation in a weekly seminar, and (c)…

  15. Developing a Comprehensive Learning Community Program: Providing a Historical Perspective

    Science.gov (United States)

    Workman, Jamie L.; Redington, Lyn

    2015-01-01

    This is the first of a three-part series which will share information about how a mid-size, comprehensive university developed a learning community program, including a residential curriculum. Through intentional collaboration and partnerships, the team, comprised of faculty and staff throughout the university, developed a "multi-year plan…

  16. The Africanisation of Academic Development Programs: A case study

    African Journals Online (AJOL)

    The Africanisation of Academic Development Programs: A case study. Phillip Higgs, RMH Moeketsi. Abstract. The question this article addresses is: what does the Africanisation of academic development programmes involve? In trying to answer this question, we shall discuss the African concepts of ubuntu and communality ...

  17. "Sustainable Development" and CIDA's China Program: A Saskatchewan Case Study

    Science.gov (United States)

    Sinclair, Paul; Blachford, Dongyan; Pickard, Garth

    2015-01-01

    Through funding from the Canadian International Development Agency's (CIDA) China Program, the University of Regina (UofR), Canada, implemented two major development projects with the Educational Institute of Jilin province (EIJP) from 1990 to 2001. This paper re-examines this historic cooperation. The paper argues that prevailing theories of…

  18. Integrated population-development program performance: the Malaysian Felda experience.

    Science.gov (United States)

    Fong, C O

    1985-01-01

    Program performance of the Malaysian Felda program, an integrated population development program, is examined in this report. It also evaluates the relationship of the performance of this program with its organizational, integrational, and community support factors. Starting in 1956, Felda had, by the end of 1981, developed 308 land schemes covering an area of 1.4 million acres planted predominantly with oil palm (59.4%) and rubber (31.6%). The land schemes have settled a total of 70,600 families or over 400,000 people. The integrated programs existing in the Felda schmes are the focus of analysis for this study. Out of the universe of 308 Felda schemes, 26 schemes were randomly selected for the study. In each scheme, 2 surveys were conducted: first, the staff surveys to gather information on the organizational factors and extent of integration in existence in the scheme and then household surveys to gather information on the extent of community support for the integrated program and the performance of the program. In the case of the performance variables, the information gathered from the household survey was supplemented by the records from the Felda scheme office. In the sample of 26 schemes, a total of 1641 settler households were selected for the household survey and 363 staff were selected for the staff survey. The surveys were conducted in the 1st quarter of 1982. The results indicate that the Felda mode of delivering population and community development services has been very effective. Over 55.2% of the eligible women were found to be practicing family planning (compared to about 35.5% for the national rural average), while over 78.9% of the eligible women utilized postnatal health care facilities. About 1 in 3 of the eligible children in Felda schemes attend kindergarten classes, while over 46.9% of the Felda households are involved in some form of extramural income generating activities. The more integrated the program in a particular community, the more

  19. Challenges in developing direct carbon fuel cells.

    Science.gov (United States)

    Jiang, Cairong; Ma, Jianjun; Corre, Gael; Jain, Sneh L; Irvine, John T S

    2017-05-22

    A direct carbon fuel cell (DCFC) can produce electricity with both superior electrical efficiency and fuel utilisation compared to all other types of fuel cells. Although the first DCFC prototype was proposed in 1896, there was, until the 1970s, little sustained effort to investigate further, because of technology development issues. Interest in DCFCs has recently been reinvigorated as a possible method of replacing conventional coal-fired power plants to meet the demands for lower CO 2 emissions, and indeed for efficient utilisation of waste derived chars. In this article, recent developments in direct carbon conversion are reviewed, with the principal emphasis on the materials involved. The development of electrolytes, anodes and cathodes as well as fuel sources is examined. The activity and chemical stability of the anode materials are a critical concern addressed in the development of new materials. Redox media of molten carbonate or molten metal facilitating the transportation of ions offer promising possibilities for carbon oxidation. The suitability of different carbon fuels in various DCFC systems, in terms of crystal structure, surface properties, impurities and particle size, is also discussed. We explore the influence of a variety of parameters on the electrochemical performance of DCFCs, with regard to their open circuit voltage, power output and lifetime. The challenges faced in developing DCFCs are summarised, and potential prospects of the system are outlined.

  20. The DEVELOP National Program's Strategy for Communicating Applied Science Outcomes

    Science.gov (United States)

    Childs-Gleason, L. M.; Ross, K. W.; Crepps, G.; Favors, J.; Kelley, C.; Miller, T. N.; Allsbrook, K. N.; Rogers, L.; Ruiz, M. L.

    2016-12-01

    NASA's DEVELOP National Program conducts rapid feasibility projects that enable the future workforce and current decision makers to collaborate and build capacity to use Earth science data to enhance environmental management and policy. The program communicates its results and applications to a broad spectrum of audiences through a variety of methods: "virtual poster sessions" that engage the general public through short project videos and interactive dialogue periods, a "Campus Ambassador Corps" that communicates about the program and its projects to academia, scientific and policy conference presentations, community engagement activities and end-of-project presentations, project "hand-offs" providing results and tools to project partners, traditional publications (both gray literature and peer-reviewed), an interactive website project gallery, targeted brochures, and through multiple social media venues and campaigns. This presentation will describe the various methods employed by DEVELOP to communicate the program's scientific outputs, target audiences, general statistics, community response and best practices.