WorldWideScience

Sample records for cell commercialization roadmap

  1. Canadian fuel cell commercialization roadmap update : progress of Canada's hydrogen and fuel cell industry

    International Nuclear Information System (INIS)

    Filbee, S.; Karlsson, T.

    2009-01-01

    Hydrogen and fuel cells are considered an essential part of future low-carbon energy systems for transportation and stationary power. In recognition of this, Industry Canada has worked in partnership with public and private stakeholders to provide an update to the 2003 Canadian Fuel Cell Commercialization Roadmap to determine infrastructure requirements for near-term markets. The update includes technology and market developments in terms of cost and performance. This presentation included an overview of global hydrogen and fuel cell markets as background and context for the activities of the Canadian industry. Approaches toward commercial viability and mass market success were also discussed along with possible scenarios and processes by which these mass markets could develop. Hydrogen and fuel cell industry priorities were outlined along with recommendations for building a hydrogen infrastructure

  2. Roadmap on semiconductor-cell biointerfaces

    Science.gov (United States)

    Tian, Bozhi; Xu, Shuai; Rogers, John A.; Cestellos-Blanco, Stefano; Yang, Peidong; Carvalho-de-Souza, João L.; Bezanilla, Francisco; Liu, Jia; Bao, Zhenan; Hjort, Martin; Cao, Yuhong; Melosh, Nicholas; Lanzani, Guglielmo; Benfenati, Fabio; Galli, Giulia; Gygi, Francois; Kautz, Rylan; Gorodetsky, Alon A.; Kim, Samuel S.; Lu, Timothy K.; Anikeeva, Polina; Cifra, Michal; Krivosudský, Ondrej; Havelka, Daniel; Jiang, Yuanwen

    2018-05-01

    This roadmap outlines the role semiconductor-based materials play in understanding the complex biophysical dynamics at multiple length scales, as well as the design and implementation of next-generation electronic, optoelectronic, and mechanical devices for biointerfaces. The roadmap emphasizes the advantages of semiconductor building blocks in interfacing, monitoring, and manipulating the activity of biological components, and discusses the possibility of using active semiconductor-cell interfaces for discovering new signaling processes in the biological world.

  3. A Commercialization Roadmap for Carbon-Negative Energy Systems

    Science.gov (United States)

    Sanchez, D.

    2016-12-01

    The Intergovernmental Panel on Climate Change (IPCC) envisages the need for large-scale deployment of net-negative CO2 emissions technologies by mid-century to meet stringent climate mitigation goals and yield a net drawdown of atmospheric carbon. Yet there are few commercial deployments of BECCS outside of niche markets, creating uncertainty about commercialization pathways and sustainability impacts at scale. This uncertainty is exacerbated by the absence of a strong policy framework, such as high carbon prices and research coordination. Here, we propose a strategy for the potential commercial deployment of BECCS. This roadmap proceeds via three steps: 1) via capture and utilization of biogenic CO2 from existing bioenergy facilities, notably ethanol fermentation, 2) via thermochemical co-conversion of biomass and fossil fuels, particularly coal, and 3) via dedicated, large-scale BECCS. Although biochemical conversion is a proven first market for BECCS, this trajectory alone is unlikely to drive commercialization of BECCS at the gigatonne scale. In contrast to biochemical conversion, thermochemical conversion of coal and biomass enables large-scale production of fuels and electricity with a wide range of carbon intensities, process efficiencies and process scales. Aside from systems integration, primarily technical barriers are involved in large-scale biomass logistics, gasification and gas cleaning. Key uncertainties around large-scale BECCS deployment are not limited to commercialization pathways; rather, they include physical constraints on biomass cultivation or CO2 storage, as well as social barriers, including public acceptance of new technologies and conceptions of renewable and fossil energy, which co-conversion systems confound. Despite sustainability risks, this commercialization strategy presents a pathway where energy suppliers, manufacturers and governments could transition from laggards to leaders in climate change mitigation efforts.

  4. Fuel Cell Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The Fuel Cell Technical Team promotes the development of a fuel cell power system for an automotive powertrain that meets the U.S. DRIVE Partnership (United States Driving Research and Innovation for Vehicle efficiency and Energy sustainability) goals.

  5. Hydrogen energy and fuel cells. Strategic Roadmap

    International Nuclear Information System (INIS)

    Moran, Pascal; Gernot, Eric; Masset, Franck; Pierre, Helene; Hody, Stephane; Julien, Marianne; Bouchard, Patrick; Lima, Alexandre; Aubree, Marc; Declerck, Bernard; Jehan, Michel; Mulard, Philippe; Le Breton, Daniel; Grouset, Didier; Lucoq, Samuel; Maio, Patrick; Lanoix, Jean-Christophe; Tisserand, Perrine; Beuzit, Pierre; Junker, Michel; Meslin, Frederic; Derive, Claude; Altman, Matthias; Vandenborre, Hugo; Pastor, Jean-Marc; Biasotto, Jerome; SOLBES, Frederic; Lucchese, Paul; Le Duigou, Alain; Lamy, Claude; Petit, Florent; Rojey, Alexandre; Strang, Axel; Frois, Bernard; Clement, Daniel; Filmon, Karine; Antoine, Loic; Bodineau, Luc; Gioria, Michel; Barbier, Cecile

    2011-04-01

    Since 2010, the ADEME (The French Environment and Energy Management Agency) has been managing four programmes within the scope of 'Future Investments'. Groups of experts from research from various industrial fields, research organisms and research programming and financing agencies are responsible, within the scope of collective works, for producing strategic road-maps. These are used to launch Calls for Expressions of Interest (CEI). The purpose of these road-maps is to: - highlight the industrial, technological, environmental and societal issues; - draw up coherent, shared visions of technologies and the socio-technical system in question; - identify the technological, organisational and socio-economic locks to be overcome; - associate time-based objectives with the priority research topics in terms of technological availability and deployment; - prioritise needs of the industrial research, research demonstrator, pre-industrial experimentation and technology test platform, which then act as a basis for: - drawing up CEIs; - programming research within the ADEME and other institutions such as the French National Research Agency (ANR), the French national strategic committee for energy research (Comite strategique national sur la recherche energie) or the French national alliance for the coordination of energy research (ANCRE). These research and experimentation priorities originate from the junction of the visions and locks, and they also take into account French capacities in the fields of research and industry. Road-maps can also refer to exemplary experiments conducted abroad and make recommendations in terms of industrial policy. This road-map shall be regularly updated. In order to draw up this road-map, the ADEME consulted with a group of experts from major private contractors, a contaminated wasteland developer, stakeholders involved in pollution control and public research and finally the ADEME

  6. Roadmap for the Future of Commercial Energy Codes

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, Michael I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hart, Philip R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhang, Jian [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Athalye, Rahul A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-01-01

    Building energy codes have significantly increased building efficiency over the last 38 years, since the first national energy code was published in 1975. The most commonly used path in energy codes, the prescriptive path, appears to be reaching a point of diminishing returns. The current focus on prescriptive codes has limitations including significant variation in actual energy performance depending on which prescriptive options are chosen, a lack of flexibility for designers and developers, the inability to handle optimization that is specific to building type and use, the inability to account for project-specific energy costs, and the lack of follow-through or accountability after a certificate of occupancy is granted. It is likely that an approach that considers the building as an integrated system will be necessary to achieve the next real gains in building efficiency. This report provides a high-level review of different formats for commercial building energy codes, including prescriptive, prescriptive packages, capacity constrained, outcome based, and predictive performance approaches. This report also explores a next generation commercial energy code approach that places a greater emphasis on performance-based criteria.

  7. planSOEC. R and D and commercialization roadmap for SOEC electrolysis. R and D of SOEC stacks with improved durability. Project report

    Energy Technology Data Exchange (ETDEWEB)

    Richter, A.; Friis Pedersen, C.; Nielsen, Jens Ulrik [Topsoe Fuel Cells A/S, Kgs. Lyngby (Denmark); Mogensen, M.; Hoejgaard Jensen, S.; Ming Chen [Technical Univ. of Denmark. Fuel Cells and Solid State Chemistry Div., DTU Risoe Campus, Roskilde (Denmark); Sloth, M. [H2 Logic A/S, Herning (Denmark)

    2011-05-15

    The project has been divided into two parts: PART 1: Formulation of a R and D and commercialization roadmap for SOEC electrolysis. PART 2: Conducting R and D of SOEC stacks with improved durability. The purpose of Part 1 has been to develop a R and D and commercialisation roadmap for hydrogen and CO production plants based on the solid oxide electrolysis cell (SOEC) technology. SOEC technology is still on an early R and D stage but years of extensive R and D within SOFC technology provides a strong platform for an accelerated commercialisation. However, in order to guide the future SOEC R and D activities towards reaching commercial market requirements a detailed roadmap is necessary. An overall strategy for R and D of various electrolysis technologies in Denmark already exists{sup 2}, formulated in the Hydrogen Production working group in the Danish Hydrogen and Fuel Cell Partnership. The SOEC roadmap developed as part of the planSOEC project supplements the overall strategy, by conducting an updated analysis of state-of-the-art. Also planSOEC provides a detailed analysis of requirements for different market applications for SOEC, which enables formulation of precise and detailed R and D targets. The objectives of Part 2 in this project were multiple: 1) To investigate durability of solid oxide cells (SOCs) and stack components under industrially relevant (''harsh'') electrolysis operating conditions; 2) to investigate performance of standard TOFC (Topsoe Fuel Cell A/S) SOC stacks (based on state-of-the-art solid oxide cells) under mild electrolysis operating conditions ({<=}0.75 A/cm{sup 2}); 3) to further develop SOEC stack computer models available at Riso DTU and TOFC. Accordingly four lines of work were carried out in the here reported project: 1) Investigation of corrosion resistance of interconnect alloys. 2) Cell and stack element testing. 3) SOEC stack testing. 4) SOEC stack modeling. (LN)

  8. Non-Hardware ("Soft") Cost-Reduction Roadmap for Residential and Small Commercial Solar Photovoltaics, 2013-2020

    Energy Technology Data Exchange (ETDEWEB)

    Ardani, K.; Seif, D.; Margolis, R.; Morris, J.; Davidson, C.; Truitt, S.; Torbert, R.

    2013-08-01

    The objective of this analysis is to roadmap the cost reductions and innovations necessary to achieve the U.S. Department of Energy (DOE) SunShot Initiative's total soft-cost targets by 2020. The roadmap focuses on advances in four soft-cost areas: (1) customer acquisition; (2) permitting, inspection, and interconnection (PII); (3) installation labor; and (4) financing. Financing cost reductions are in terms of the weighted average cost of capital (WACC) for financing PV system installations, with real-percent targets of 3.0% (residential) and 3.4% (commercial).

  9. Commercialization of fuel-cells

    Energy Technology Data Exchange (ETDEWEB)

    Penner, S.S.; Appleby, A.J.; Baker, B.S.; Bates, J.L.; Buss, L.B.; Dollard, W.J.; Farris, P.J.; Gillis, E.A.; Gunsher, J.A.; Khandkar, A.; Krumpelt, M.; O' Sullivan, J.B.; Runte, G.; Savinell, R.F.; Selman, J.R.; Shores, D.A.; Tarman, P.

    1995-03-01

    This report is an abbreviated version of the ''Report of the DOE Advanced Fuel Cell Commercialization Working Group (AFC2WG),'' released January 1995. We describe fuel-cell commercialization for stationary power applications of phosphoric acid, molten carbonate, solid oxide, and polymer electrolyte membrane fuel cells.

  10. Commercializing fuel cells: managing risks

    Science.gov (United States)

    Bos, Peter B.

    Commercialization of fuel cells, like any other product, entails both financial and technical risks. Most of the fuel cell literature has focussed upon technical risks, however, the most significant risks during commercialization may well be associated with the financial funding requirements of this process. Successful commercialization requires an integrated management of these risks. Like any developing technology, fuel cells face the typical 'Catch-22' of commercialization: "to enter the market, the production costs must come down, however, to lower these costs, the cumulative production must be greatly increased, i.e. significant market penetration must occur". Unless explicit steps are taken to address this dilemma, fuel cell commercialization will remain slow and require large subsidies for market entry. To successfully address this commercialization dilemma, it is necessary to follow a market-driven commercialization strategy that identifies high-value entry markets while minimizing the financial and technical risks of market entry. The financial and technical risks of fuel cell commercialization are minimized, both for vendors and end-users, with the initial market entry of small-scale systems into high-value stationary applications. Small-scale systems, in the order of 1-40 kW, benefit from economies of production — as opposed to economies to scale — to attain rapid cost reductions from production learning and continuous technological innovation. These capital costs reductions will accelerate their commercialization through market pull as the fuel cell systems become progressively more viable, starting with various high-value stationary and, eventually, for high-volume mobile applications. To facilitate market penetration via market pull, fuel cell systems must meet market-derived economic and technical specifications and be compatible with existing market and fuels infrastructures. Compatibility with the fuels infrastructure is facilitated by a

  11. A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Lay Teng Ang

    2018-02-01

    Full Text Available How are closely related lineages, including liver, pancreas, and intestines, diversified from a common endodermal origin? Here, we apply principles learned from developmental biology to rapidly reconstitute liver progenitors from human pluripotent stem cells (hPSCs. Mapping the formation of multiple endodermal lineages revealed how alternate endodermal fates (e.g., pancreas and intestines are restricted during liver commitment. Human liver fate was encoded by combinations of inductive and repressive extracellular signals at different doses. However, these signaling combinations were temporally re-interpreted: cellular competence to respond to retinoid, WNT, TGF-β, and other signals sharply changed within 24 hr. Consequently, temporally dynamic manipulation of extracellular signals was imperative to suppress the production of unwanted cell fates across six consecutive developmental junctures. This efficiently generated 94.1% ± 7.35% TBX3+HNF4A+ human liver bud progenitors and 81.5% ± 3.2% FAH+ hepatocyte-like cells by days 6 and 18 of hPSC differentiation, respectively; the latter improved short-term survival in the Fah−/−Rag2−/−Il2rg−/− mouse model of liver failure.

  12. Parabolic-trough technology roadmap: A pathway for sustained commercial development and deployment of parabolic-trough technology

    International Nuclear Information System (INIS)

    David Kearney; Hank Price

    1999-01-01

    Technology roadmapping is a needs-driven technology planning process to help identify, select, and develop technology alternatives to satisfy a set of market needs. The DOE's Office of Power Technologies' Concentrating Solar Power (CSP) Program recently sponsored a technology roadmapping workshop for parabolic trough technology. The workshop was attended by an impressive cross section of industry and research experts. The goals of the workshop were to evaluate the market potential for trough power projects, develop a better understanding of the current state of the technology, and to develop a conceptual plan for advancing the state of parabolic trough technology. This report documents and extends the roadmap that was conceptually developed during the workshop

  13. Parabolic-Trough Technology Roadmap: A Pathway for Sustained Commercial Development and Deployment of Parabolic-Trough Technology

    Energy Technology Data Exchange (ETDEWEB)

    Price, H.; Kearney, D.

    1999-01-31

    Technology roadmapping is a needs-driven technology planning process to help identify, select, and develop technology alternatives to satisfy a set of market needs. The DOE's Office of Power Technologies' Concentrating Solar Power (CSP) Program recently sponsored a technology roadmapping workshop for parabolic trough technology. The workshop was attended by an impressive cross section of industry and research experts. The goals of the workshop were to evaluate the market potential for trough power projects, develop a better understanding of the current state of the technology, and to develop a conceptual plan for advancing the state of parabolic trough technology. This report documents and extends the roadmap that was conceptually developed during the workshop.

  14. Navigating the transcriptional roadmap regulating plant secondary cell wall deposition

    Directory of Open Access Journals (Sweden)

    Steven Grant Hussey

    2013-08-01

    Full Text Available The current status of lignocellulosic biomass as an invaluable resource in industry, agriculture and health has spurred increased interest in understanding the transcriptional regulation of secondary cell wall (SCW biosynthesis. The last decade of research has revealed an extensive network of NAC, MYB and other families of transcription factors regulating Arabidopsis SCW biosynthesis, and numerous studies have explored SCW-related transcription factors in other dicots and monocots. Whilst the general structure of the Arabidopsis network has been a topic of several reviews, they have not comprehensively represented the detailed protein-DNA and protein-protein interactions described in the literature, and an understanding of network dynamics and functionality has not yet been achieved for SCW formation. Furthermore the methodologies employed in studies of SCW transcriptional regulation have not received much attention, especially in the case of non-model organisms. In this review, we have reconstructed the most exhaustive literature-based network representations to date of SCW transcriptional regulation in Arabidopsis. We include a manipulable Cytoscape representation of the Arabidopsis SCW transcriptional network to aid in future studies, along with a list of supporting literature for each documented interaction. Amongst other topics, we discuss the various components of the network, its evolutionary conservation in plants, putative modules and dynamic mechanisms that may influence network function, and the approaches that have been employed in network inference. Future research should aim to better understand network function and its response to dynamic perturbations, whilst the development and application of genome-wide approaches such as ChIP-seq and systems genetics are in progress for the study of SCW transcriptional regulation in non-model organisms.

  15. Issues in fuel cell commercialization

    Science.gov (United States)

    Appleby, A. J.

    After 25 years of effort, the phosphoric acid fuel cell (PAFC) is approaching commercialization as cell stack assemblies (CAS) show convincingly low degradation and its balance-of-plant (BOP) achieves mature reliability. A high present capital cost resulting from limited cumulative production remains an issue. The primary PAFC developer in the USA (International Fuel Cells, IFC) has only manufactured 40 MW of PAFC components to date, the equivalent of a single large gas turbine aero-engine or 500 compact car engines. The system is therefore still far up the production learning curve. Even so, the next generation of on-site 40% electrical efficiency (LHV) combined heat-and-power (CHP) PAFC system was available for order from IFC in 1995 at US 3000/kW (1995). To effectively compete in the marketplace with diesel generators, the dispersed cogeneration PAFC must cost approximately US 1550/kW (1995) in the USA and Europe. At somewhat lower costs than this, dispersed cogeneration PAFCs will compete with large combined-cycle generators. However, in Japan, costs greater than US 2000/kW will be competitive, based on the late-1995 trade exchange rate of 100-105 Yen/US ). The perceived advantages of fuel cell technologies over developments of more conventional generators (e.g., ultra-low emissions, siting) are not strong selling points in the marketplace. The ultimate criterion is cost. Cost reduction is now the key to market penetration. This must include reduced installation costs, for which the present goal is US$ 385/kW (1995). How further capital cost reductions can be achieved by the year 2000 is discussed. Progress to date is reviewed, and the potential for pressurized electric utility PAFC units is determined. Markets for high-temperature fuel cell system (molten carbonate, MCFC, and solid oxide, SOFC), which many consider to be 20 and 30 years, respectively, behind the PAFC, are discussed. Their high efficiency and high-quality waste heat should make them attractive

  16. A Continuous Molecular Roadmap to iPSC Reprogramming through Progression Analysis of Single-Cell Mass Cytometry

    OpenAIRE

    Zunder, Eli R.; Lujan, Ernesto; Goltsev, Yury; Wernig, Marius; Nolan, Garry P.

    2015-01-01

    To analyze cellular reprogramming at the single-cell level, mass cytometry was used to simultaneously measure markers of pluripotency, differentiation, cell-cycle status, and cellular signaling throughout the reprogramming process. Time-resolved progression analysis of the resulting data sets was used to construct a continuous molecular roadmap for three independent reprogramming systems. Although these systems varied substantially in Oct4, Sox2, Klf4, and c-Myc stoichiometry, they presented ...

  17. CMMI Roadmaps

    National Research Council Canada - National Science Library

    Cannegieter, Jan J; Heijstek, Andre; Linders, Ben; Solingen, Rini van

    2008-01-01

    .... The Dutch Software Process Improvement (SPIder) network convened a workshop in November 2006 to develop several CMMI roadmaps for the continuous representation, each with a specific set of improvement goals...

  18. Scientific Assessment in support of the Materials Roadmap enabling Low Carbon Energy Technologies: Hydrogen and Fuel Cells

    DEFF Research Database (Denmark)

    Cerri, I.; Lefebvre-Joud, F.; Holtappels, Peter

    A group of experts from European research organisations and industry have assessed the state of the art and future needs for materials' R&D for hydrogen and fuel cell technologies. The work was performed as input to the European Commission's roadmapping exercise on materials for the European...... Strategic Energy Technology Plan. The report summarises the results, including key targets identified for medium term (2020/2030) and long term (2050) timescales....

  19. BMT Roadmap: A User-Centered Design Health Information Technology Tool to Promote Patient-Centered Care in Pediatric Hematopoietic Cell Transplantation.

    Science.gov (United States)

    Runaas, Lyndsey; Hanauer, David; Maher, Molly; Bischoff, Evan; Fauer, Alex; Hoang, Tiffany; Munaco, Anna; Sankaran, Roshun; Gupta, Rahael; Seyedsalehi, Sajjad; Cohn, Amy; An, Larry; Tewari, Muneesh; Choi, Sung Won

    2017-05-01

    Health information technology (HIT) has great potential for increasing patient engagement. Pediatric hematopoietic cell transplantation (HCT) is a setting ripe for using HIT but in which little research exists. "BMT Roadmap" is a web-based application that integrates patient-specific information and includes several domains: laboratory results, medications, clinical trial details, photos of the healthcare team, trajectory of transplant process, and discharge checklist. BMT Roadmap was provided to 10 caregivers of patients undergoing first-time HCT. Research assistants performed weekly qualitative interviews throughout the patient's hospitalization and at discharge and day 100 to assess the impact of BMT Roadmap. Rigorous thematic analysis revealed 5 recurrent themes: emotional impact of the HCT process itself; critical importance of communication among patients, caregivers, and healthcare providers; ways in which BMT Roadmap was helpful during inpatient setting; suggestions for improving BMT Roadmap; and other strategies for organization and management of complex healthcare needs that could be incorporated into BMT Roadmap. Caregivers found the tool useful and easy to use, leading them to want even greater access to information. BMT Roadmap was feasible, with no disruption to inpatient care. Although this initial study is limited by the small sample size and single-institution experience, these initial findings are encouraging and support further investigation. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  20. Vehicle Battery Safety Roadmap Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Doughty, D. H.

    2012-10-01

    The safety of electrified vehicles with high capacity energy storage devices creates challenges that must be met to assure commercial acceptance of EVs and HEVs. High performance vehicular traction energy storage systems must be intrinsically tolerant of abusive conditions: overcharge, short circuit, crush, fire exposure, overdischarge, and mechanical shock and vibration. Fail-safe responses to these conditions must be designed into the system, at the materials and the system level, through selection of materials and safety devices that will further reduce the probability of single cell failure and preclude propagation of failure to adjacent cells. One of the most important objectives of DOE's Office of Vehicle Technologies is to support the development of lithium ion batteries that are safe and abuse tolerant in electric drive vehicles. This Roadmap analyzes battery safety and failure modes of state-of-the-art cells and batteries and makes recommendations on future investments that would further DOE's mission.

  1. National Algal Biofuels Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, John [Dept. of Energy (DOE), Washington DC (United States); Sarisky-Reed, Valerie [Dept. of Energy (DOE), Washington DC (United States)

    2010-05-01

    The framework for National Algal Biofuels Technology Roadmap was constructed at the Algal Biofuels Technology Roadmap Workshop, held December 9-10, 2008, at the University of Maryland-College Park. The Workshop was organized by the Biomass Program to discuss and identify the critical challenges currently hindering the development of a domestic, commercial-scale algal biofuels industry. This Roadmap presents information from a scientific, economic, and policy perspectives that can support and guide RD&D investment in algal biofuels. While addressing the potential economic and environmental benefits of using algal biomass for the production of liquid transportation fuels, the Roadmap describes the current status of algae RD&D. In doing so, it lays the groundwork for identifying challenges that likely need to be overcome for algal biomass to be used in the production of economically viable biofuels.

  2. Exploration and Mining Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2002-09-01

    This Exploration and Mining Technology Roadmap represents the third roadmap for the Mining Industry of the Future. It is based upon the results of the Exploration and Mining Roadmap Workshop held May 10 ñ 11, 2001.

  3. Codes & standards research, development & demonstration Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-07-22

    This Roadmap is a guide to the Research, Development & Demonstration activities that will provide data required for SDOs to develop performance-based codes and standards for a commercial hydrogen fueled transportation sector in the U.S.

  4. Limitations of Commercializing Fuel Cell Technologies

    Science.gov (United States)

    Nordin, Normayati

    2010-06-01

    Fuel cell is the technology that, nowadays, is deemed having a great potential to be used in supplying energy. Basically, fuel cells can be categorized particularly by the kind of employed electrolyte. Several fuel cells types which are currently identified having huge potential to be utilized, namely, Solid Oxide Fuel Cells (SOFC), Molten Carbonate Fuel Cells (MCFC), Alkaline Fuel Cells (AFC), Phosphoric Acid Fuel Cells (PAFC), Polymer Electron Membrane Fuel Cell (PEMFC), Direct Methanol Fuel Cells (DMFC) and Regenerative Fuel Cells (RFC). In general, each of these fuel cells types has their own characteristics and specifications which assign the capability and suitability of them to be utilized for any particular applications. Stationary power generations and transport applications are the two most significant applications currently aimed for the fuel cell market. It is generally accepted that there are lots of advantages if fuel cells can be excessively commercialized primarily in context of environmental concerns and energy security. Nevertheless, this is a demanding task to be accomplished, as there is some gap in fuel cells technology itself which needs a major enhancement. It can be concluded, from the previous study, cost, durability and performance are identified as the main limitations to be firstly overcome in enabling fuel cells technology become viable for the market.

  5. Stationary power fuel cell commercialization status worldwide

    Energy Technology Data Exchange (ETDEWEB)

    Williams, M.C. [Dept. of Energy, Morgantown, WV (United States)

    1996-12-31

    Fuel cell technologies for stationary power are set to play a role in power generation applications worldwide. The worldwide fuel cell vision is to provide powerplants for the emerging distributed generation and on-site markets. Progress towards commercialization has occurred in all fuel cell development areas. Around 100 ONSI phosphoric acid fuel cell (PAFC) units have been sold, with significant foreign sales in Europe and Japan. Fuji has apparently overcome its PAFC decay problems. Industry-driven molten carbonate fuel cell (MCFC) programs in Japan and the U.S. are conducting megawatt (MW)-class demonstrations, which are bringing the MCFC to the verge of commercialization. Westinghouse Electric, the acknowledged world leader in tubular solid oxide fuel cell (SOFC) technology, continues to set performance records and has completed construction of a 4-MW/year manufacturing facility in the U.S. Fuel cells have also taken a major step forward with the conceptual development of ultra-high efficiency fuel cell/gas turbine plants. Many SOFC developers in Japan, Europe, and North America continue to make significant advances.

  6. Research & Development Roadmap for Next-Generation Appliances

    Energy Technology Data Exchange (ETDEWEB)

    Goetzler, William [Navigant Consulting, Inc., Burlington, MA (United States); Sutherland, Timothy [Navigant Consulting, Inc., Burlington, MA (United States); Foley, Kevin [Navigant Consulting, Inc., Burlington, MA (United States)

    2012-03-01

    Appliances present an attractive opportunity for near-term energy savings in existing building, because they are less expensive and replaced more regularly than heating, ventilation, and air-conditioning (HVAC) systems or building envelope components. This roadmap targets high-priority research and development (R&D), demonstration and commercialization activities that could significantly reduce residential appliance energy consumption. The main objective of the roadmap is to seek activities that accelerate the commercialization of high-efficiency appliance technologies while maintaining the competitiveness of American industry. The roadmap identified and evaluated potential technical innovations, defined research needs, created preliminary research and development roadmaps, and obtained stakeholder feedback on the proposed initiatives.

  7. Roadmap for Inclusive Innovation

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — The Roadmap for Inclusive Innovation data set shares the status of action items under the Roadmap for Inclusive Innovation. Each action or project has been assigned...

  8. Aluminum Industry Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2003-02-01

    This roadmap describes the industry's R&D strategy, priorities, milestones, and performance targets for achieving its long-term goals. It accounts for changes in the industry and the global marketplace since the first roadmap was published in 1997. An updated roadmap was published November 2001. (PDF 1.1 MB).

  9. Codes and standards research, development and demonstration roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-07-22

    C&S RD&D Roadmap - 2008: This Roadmap is a guide to the Research, Development & Demonstration activities that will provide data required for Standards Development Organizations (SDOs) to develop performance-based codes and standards for a commercial hydrogen fueled transportation sector in the U.S.

  10. Roadmap on optical security

    Science.gov (United States)

    Javidi, Bahram; Carnicer, Artur; Yamaguchi, Masahiro; Nomura, Takanori; Pérez-Cabré, Elisabet; Millán, María S.; Nishchal, Naveen K.; Torroba, Roberto; Fredy Barrera, John; He, Wenqi; Peng, Xiang; Stern, Adrian; Rivenson, Yair; Alfalou, A.; Brosseau, C.; Guo, Changliang; Sheridan, John T.; Situ, Guohai; Naruse, Makoto; Matsumoto, Tsutomu; Juvells, Ignasi; Tajahuerce, Enrique; Lancis, Jesús; Chen, Wen; Chen, Xudong; Pinkse, Pepijn W. H.; Mosk, Allard P.; Markman, Adam

    2016-08-01

    Information security and authentication are important challenges facing society. Recent attacks by hackers on the databases of large commercial and financial companies have demonstrated that more research and development of advanced approaches are necessary to deny unauthorized access to critical data. Free space optical technology has been investigated by many researchers in information security, encryption, and authentication. The main motivation for using optics and photonics for information security is that optical waveforms possess many complex degrees of freedom such as amplitude, phase, polarization, large bandwidth, nonlinear transformations, quantum properties of photons, and multiplexing that can be combined in many ways to make information encryption more secure and more difficult to attack. This roadmap article presents an overview of the potential, recent advances, and challenges of optical security and encryption using free space optics. The roadmap on optical security is comprised of six categories that together include 16 short sections written by authors who have made relevant contributions in this field. The first category of this roadmap describes novel encryption approaches, including secure optical sensing which summarizes double random phase encryption applications and flaws [Yamaguchi], the digital holographic encryption in free space optical technique which describes encryption using multidimensional digital holography [Nomura], simultaneous encryption of multiple signals [Pérez-Cabré], asymmetric methods based on information truncation [Nishchal], and dynamic encryption of video sequences [Torroba]. Asymmetric and one-way cryptosystems are analyzed by Peng. The second category is on compression for encryption. In their respective contributions, Alfalou and Stern propose similar goals involving compressed data and compressive sensing encryption. The very important area of cryptanalysis is the topic of the third category with two sections

  11. Flight Avionics Hardware Roadmap

    Science.gov (United States)

    Hodson, Robert; McCabe, Mary; Paulick, Paul; Ruffner, Tim; Some, Rafi; Chen, Yuan; Vitalpur, Sharada; Hughes, Mark; Ling, Kuok; Redifer, Matt; hide

    2013-01-01

    As part of NASA's Avionics Steering Committee's stated goal to advance the avionics discipline ahead of program and project needs, the committee initiated a multi-Center technology roadmapping activity to create a comprehensive avionics roadmap. The roadmap is intended to strategically guide avionics technology development to effectively meet future NASA missions needs. The scope of the roadmap aligns with the twelve avionics elements defined in the ASC charter, but is subdivided into the following five areas: Foundational Technology (including devices and components), Command and Data Handling, Spaceflight Instrumentation, Communication and Tracking, and Human Interfaces.

  12. Enterprise Architecture (EA) Roadmap

    Data.gov (United States)

    Office of Personnel Management — The Enterprise Roadmap reflects the information technology (IT) investment priorities established in agency PortfolioStat reviews, as well as IT program decisions...

  13. The Epigenetic Reprogramming Roadmap in Generation of iPSCs from Somatic Cells

    DEFF Research Database (Denmark)

    Brix, Jacob; Zhou, Yan; Luo, Yonglun

    2015-01-01

    Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is a comprehensive epigenetic process involving genome-wide modifications of histones and DNA methylation. This process is often incomplete, which subsequently affects iPSC reprograming, pluripotency, and differentiation...... capacity. Here we review the epigenetic changes with a focus on histone modification (methylation and acetylation) and DNA modification (methylation) during iPSC induction. We look at changes in specific epigenetic signatures, aberrations and epigenetic memory during reprogramming and small molecules...... influencing the epigenetic reprogramming of somatic cells. Finally, we discuss how to improve iPSC generation and pluripotency through epigenetic manipulations....

  14. The Epigenetic Reprogramming Roadmap in Generation of iPSCs from Somatic Cells.

    Science.gov (United States)

    Brix, Jacob; Zhou, Yan; Luo, Yonglun

    2015-12-20

    Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is a comprehensive epigenetic process involving genome-wide modifications of histones and DNA methylation. This process is often incomplete, which subsequently affects iPSC reprogramming, pluripotency, and differentiation capacity. Here, we review the epigenetic changes with a focus on histone modification (methylation and acetylation) and DNA modification (methylation) during iPSC induction. We look at changes in specific epigenetic signatures, aberrations and epigenetic memory during reprogramming and small molecules influencing the epigenetic reprogramming of somatic cells. Finally, we discuss how to improve iPSC generation and pluripotency through epigenetic manipulations. Copyright © 2015 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

  15. Patterning roadmap: 2017 prospects

    Science.gov (United States)

    Neisser, Mark

    2017-06-01

    Road mapping of semiconductor chips has been underway for over 20 years, first with the International Technology Roadmap for Semiconductors (ITRS) roadmap and now with the International Roadmap for Devices and Systems (IRDS) roadmap. The original roadmap was mostly driven bottom up and was developed to ensure that the large numbers of semiconductor producers and suppliers had good information to base their research and development on. The current roadmap is generated more top-down, where the customers of semiconductor chips anticipate what will be needed in the future and the roadmap projects what will be needed to fulfill that demand. The More Moore section of the roadmap projects that advanced logic will drive higher-resolution patterning, rather than memory chips. Potential solutions for patterning future logic nodes can be derived as extensions of `next-generation' patterning technologies currently under development. Advanced patterning has made great progress, and two `next-generation' patterning technologies, EUV and nanoimprint lithography, have potential to be in production as early as 2018. The potential adoption of two different next-generation patterning technologies suggests that patterning technology is becoming more specialized. This is good for the industry in that it lowers overall costs, but may lead to slower progress in extending any one patterning technology in the future.

  16. Strategies for the commercial introduction of modular low power fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, H.V.; Laufer, A. [EnergiaH, Rio de Janeiro (Brazil); Miranda, P.E.V. [Coppe-Federal Univ., Rio de Janeiro (Brazil). Hydrogen Lab.

    2010-07-01

    The reality of the infrastructure in emerging economies brings the opportunity to build up a hydrogen compatible economy. For the Brazilian case, the fast development in many fields coexists with a considerable amount of potential renewable fuels available. Costs of energy distribution and of power grid maintenance throughout a continental size country may lead to a distributed generation system based in a diversified fuels matrix. This pathway drives attention to simpler low power fuel cell devices, with easier maintenance procedures, friendly integration with small power demands, and the capability of being applied separately or integrated to deliver higher power demands. Big cities and small distant agriculture based locations, such as Rio de Janeiro or rain forest extractive communities, could be able to produce fuel and energy in their own infrastructure projects. This article presents a market roadmap for the commercial introduction of direct oxidation type solid oxide fuel cells in Brazil, specifying fuel cell technological features and the specificities for each type of application, either in grid connected or in stand alone low power electric energy generation. (orig.)

  17. Fundamentals of technology roadmapping

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, M.L.; Bray, O.H.

    1997-04-01

    Technology planning is important for many reasons. Globally, companies are facing many competitive problems. Technology roadmapping, a form of technology planning can help deal with this increasingly competitive environment. While it has been used by some companies and industries, the focus has always been on the technology roadmap as a product, not on the process. This report focuses on formalizing the process so that it can be more broadly and easily used. As a DOE national security laboratory with R&D as a major product, Sandia must do effective technology planning to identify and develop the technologies required to meet its national security mission. Once identified, technology enhancements or new technologies may be developed internally or collaboratively with external partners. For either approach, technology roadmapping, as described in this report, is an effective tool for technology planning and coordination, which fits within a broader set of planning activities. This report, the second in a series on technology roadmapping, develops and documents this technology roadmapping process, which can be used by Sandia, other national labs, universities, and industry. The main benefit of technology roadmapping is that it provides information to make better technology investment decisions by identifying critical technologies and technology gaps and identifying ways to leverage R&D investments. It can also be used as a marketing tool. Technology roadmapping is critical when the technology investment decision is not straight forward. This occurs when it is not clear which alternative to pursue, how quickly the technology is needed, or when there is a need to coordinate the development of multiple technologies. The technology roadmapping process consists of three phases - preliminary activity, development of the technology roadmap, and follow-up activity.

  18. Energy Roadmap 2050

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-02-15

    On 15 December 2011, the European Commission adopted the Communication 'Energy Roadmap 2050'. The EU is committed to reducing greenhouse gas emissions to 80-95% below 1990 levels by 2050 in the context of necessary reductions by developed countries as a group. In the Energy Roadmap 2050 the Commission explores the challenges posed by delivering the EU's decarbonisation objective while at the same time ensuring security of energy supply and competitiveness. The Energy Roadmap 2050 is the basis for developing a long-term European framework together with all stakeholders.

  19. Roadmap on optical energy conversion

    Science.gov (United States)

    Boriskina, Svetlana V.; Green, Martin A.; Catchpole, Kylie; Yablonovitch, Eli; Beard, Matthew C.; Okada, Yoshitaka; Lany, Stephan; Gershon, Talia; Zakutayev, Andriy; Tahersima, Mohammad H.; Sorger, Volker J.; Naughton, Michael J.; Kempa, Krzysztof; Dagenais, Mario; Yao, Yuan; Xu, Lu; Sheng, Xing; Bronstein, Noah D.; Rogers, John A.; Alivisatos, A. Paul; Nuzzo, Ralph G.; Gordon, Jeffrey M.; Wu, Di M.; Wisser, Michael D.; Salleo, Alberto; Dionne, Jennifer; Bermel, Peter; Greffet, Jean-Jacques; Celanovic, Ivan; Soljacic, Marin; Manor, Assaf; Rotschild, Carmel; Raman, Aaswath; Zhu, Linxiao; Fan, Shanhui; Chen, Gang

    2016-07-01

    For decades, progress in the field of optical (including solar) energy conversion was dominated by advances in the conventional concentrating optics and materials design. In recent years, however, conceptual and technological breakthroughs in the fields of nanophotonics and plasmonics combined with a better understanding of the thermodynamics of the photon energy-conversion processes reshaped the landscape of energy-conversion schemes and devices. Nanostructured devices and materials that make use of size quantization effects to manipulate photon density of states offer a way to overcome the conventional light absorption limits. Novel optical spectrum splitting and photon-recycling schemes reduce the entropy production in the optical energy-conversion platforms and boost their efficiencies. Optical design concepts are rapidly expanding into the infrared energy band, offering new approaches to harvest waste heat, to reduce the thermal emission losses, and to achieve noncontact radiative cooling of solar cells as well as of optical and electronic circuitries. Light-matter interaction enabled by nanophotonics and plasmonics underlie the performance of the third- and fourth-generation energy-conversion devices, including up- and down-conversion of photon energy, near-field radiative energy transfer, and hot electron generation and harvesting. Finally, the increased market penetration of alternative solar energy-conversion technologies amplifies the role of cost-driven and environmental considerations. This roadmap on optical energy conversion provides a snapshot of the state of the art in optical energy conversion, remaining challenges, and most promising approaches to address these challenges. Leading experts authored 19 focused short sections of the roadmap where they share their vision on a specific aspect of this burgeoning research field. The roadmap opens up with a tutorial section, which introduces major concepts and terminology. It is our hope that the roadmap

  20. Metalcasting Industry Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1998-01-01

    The Roadmap sets out the strategy for pursuing near-, mid-, and long-term goals set out by industry and for carrying out the cooperative agreement between the U.S. Department of Energy and industry. The Roadmap outlines key goals for products and markets, materials technology, manufacturing technology, environmental technology, human resources, and industry health programs. The Roadmap sets out the strategy for pursuing near-, mid-, and long-term goals set out by industry and for carrying out the cooperative agreement between the U.S. Department of Energy and industry. The Roadmap sets out the strategy for pursuing near-, mid-, and long-term goals set out by industry and for carrying out the cooperative agreement between the U.S. Department of Energy and industry.

  1. 2010 Hydrogen and Fuel Cell Global Commercialization & Development Update

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-11-01

    This report offers examples of real-world applications and technical progress of hydrogen and fuel cell technologies, including policies adopted by countries to increase technology development and commercialization.

  2. mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging.

    Science.gov (United States)

    Menendez, Javier A; Vellon, Luciano; Oliveras-Ferraros, Cristina; Cufí, Sílvia; Vazquez-Martin, Alejandro

    2011-11-01

    mitochondrial function and in the accelerated onset of the glycolytic metabolism that is required to fuel reprogramming. By critically exploring how mTOR-regulated senescence, bioenergetic infrastructure and autophagy can actively drive the reprogramming of somatic cells to pluripotency, we define a metabolic roadmap that may be helpful for designing pharmacological and behavioral interventions to prevent or retard the dysfunction/exhaustion of aging stem cell populations.

  3. Technology Roadmaps: Solar photovoltaic energy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Solar PV power is a commercially available and reliable technology with a significant potential for long-term growth in nearly all world regions. This roadmap estimates that by 2050, PV will provide around 11% of global electricity production and avoid 2.3 gigatonnes (Gt) of CO2 emissions per year. Achieving this roadmap's vision will require an effective, long-term and balanced policy effort in the next decade to allow for optimal technology progress, cost reduction and ramp-up of industrial manufacturing for mass deployment. Governments will need to provide long-term targets and supporting policies to build confidence for investments in manufacturing capacity and deployment of PV systems. PV will achieve grid parity -- i.e. competitiveness with electricity grid retail prices -- by 2020 in many regions. As grid parity is achieved, the policy framework should evolve towards fostering self-sustained markets, with the progressive phase-out of economic incentives, but maintaining grid access guarantees and sustained R&D support.

  4. Heat Roadmap Europe

    DEFF Research Database (Denmark)

    Connolly, David; Mathiesen, Brian Vad; Lund, Henrik

    2015-01-01

    This document is a summary of the key technical inputs for the modelling of the heat strategy for Europe outlined in the latest Heat Roadmap Europe studies [1, 2]. These studies quantify the impact of alternative heating strategies for Europe in 2030 and 2050. The study is based on geographical...... information systems (GIS) and energy system analyses. In this report, the inputs for other modelling tools such as PRIMES are presented, in order to enable other researches to generate similar heating scenarios for Europe. Although Heat Roadmap Europe presents a complete heat strategy for Europe, which...... to model increased penetrations of district heating in the EU energy system in other energy planning tools, such as the PRIMES and JRC-EU-TIMES tools. The key results from the Heat Roadmap Europe studies are that:  Heat savings have a key role to play, but there is a socio-economic limit: after reducing...

  5. Roadmap on plasmonics

    Science.gov (United States)

    Stockman, Mark I.; Kneipp, Katrin; Bozhevolnyi, Sergey I.; Saha, Soham; Dutta, Aveek; Ndukaife, Justus; Kinsey, Nathaniel; Reddy, Harsha; Guler, Urcan; Shalaev, Vladimir M.; Boltasseva, Alexandra; Gholipour, Behrad; Krishnamoorthy, Harish N. S.; MacDonald, Kevin F.; Soci, Cesare; Zheludev, Nikolay I.; Savinov, Vassili; Singh, Ranjan; Groß, Petra; Lienau, Christoph; Vadai, Michal; Solomon, Michelle L.; Barton, David R., III; Lawrence, Mark; Dionne, Jennifer A.; Boriskina, Svetlana V.; Esteban, Ruben; Aizpurua, Javier; Zhang, Xiang; Yang, Sui; Wang, Danqing; Wang, Weijia; Odom, Teri W.; Accanto, Nicolò; de Roque, Pablo M.; Hancu, Ion M.; Piatkowski, Lukasz; van Hulst, Niek F.; Kling, Matthias F.

    2018-04-01

    Plasmonics is a rapidly developing field at the boundary of physical optics and condensed matter physics. It studies phenomena induced by and associated with surface plasmons—elementary polar excitations bound to surfaces and interfaces of good nanostructured metals. This Roadmap is written collectively by prominent researchers in the field of plasmonics. It encompasses selected aspects of nanoplasmonics. Among them are fundamental aspects, such as quantum plasmonics based on the quantum-mechanical properties of both the underlying materials and the plasmons themselves (such as their quantum generator, spaser), plasmonics in novel materials, ultrafast (attosecond) nanoplasmonics, etc. Selected applications of nanoplasmonics are also reflected in this Roadmap, in particular, plasmonic waveguiding, practical applications of plasmonics enabled by novel materials, thermo-plasmonics, plasmonic-induced photochemistry and photo-catalysis. This Roadmap is a concise but authoritative overview of modern plasmonics. It will be of interest to a wide audience of both fundamental physicists and chemists, as well as applied scientists and engineers.

  6. EV Charging Infrastructure Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Karner, Donald [Electric Transportation Inc., Rogers, AR (United States); Garetson, Thomas [Electric Transportation Inc., Rogers, AR (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-08-01

    As highlighted in the U.S. Department of Energy’s EV Everywhere Grand Challenge, vehicle technology is advancing toward an objective to “… produce plug-in electric vehicles that are as affordable and convenient for the average American family as today’s gasoline-powered vehicles …” [1] by developing more efficient drivetrains, greater battery energy storage per dollar, and lighter-weight vehicle components and construction. With this technology advancement and improved vehicle performance, the objective for charging infrastructure is to promote vehicle adoption and maximize the number of electric miles driven. The EV Everywhere Charging Infrastructure Roadmap (hereafter referred to as Roadmap) looks forward and assumes that the technical challenges and vehicle performance improvements set forth in the EV Everywhere Grand Challenge will be met. The Roadmap identifies and prioritizes deployment of charging infrastructure in support of this charging infrastructure objective for the EV Everywhere Grand Challenge

  7. Technology Roadmaps: Cement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    To support its roadmap work focusing on key technologies for emissions reductions, the International Energy Agency (IEA) also investigated one particular industry: cement. Cement production includes technologies that are both specific to this industry and those that are shared with other industries (e.g., grinding, fuel preparation, combustion, crushing, transport). An industry specific roadmap provides an effective mechanism to bring together several technology options. It outlines the potential for technological advancement for emissions reductions in one industry, as well as potential cross-industry collaboration.

  8. National hydrogen energy roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2002-11-01

    This report was unveiled by Energy Secretary Spencer Abraham in November 2002 and provides a blueprint for the coordinated, long-term, public and private efforts required for hydrogen energy development. Based on the results of the government-industry National Hydrogen Energy Roadmap Workshop, held in Washington, DC on April 2-3, 2002, it displays the development of a roadmap for America's clean energy future and outlines the key barriers and needs to achieve the hydrogen vision goals defined in

  9. Technology roadmap for lithium ion batteries 2030; Technologie-Roadmap Lithium-Ionen-Batterien 2030

    Energy Technology Data Exchange (ETDEWEB)

    Thielmann, Axel; Isenmann, Ralf; Wietschel, Martin [Fraunhofer-Institut fuer Systemtechnik und Innovationsforschung (ISI), Karlsruhe (Germany)

    2010-07-01

    The technology roadmap for lithium ion batteries 2030 presents a graphical representation of the cell components, cell types and cell characteristics of lithium ion batteries and their connection with the surrounding technology field from today through 2030. This is a farsighted orientation on the way into the future and an implementation of the ''Roadmap: Batterieforschung Deutschland'' of the BMBF (Federal Ministry of Education and Science). The developments in lithium ion batteries are identified through 2030 form today's expert view in battery development and neighbouring areas. (orig.)

  10. Current status of the TSensor systems roadmap

    NARCIS (Netherlands)

    Walsh, Steven Thomas; Bryzek, Janusz; Pisano, Albert P.

    2014-01-01

    We apply our work from the contemporary pharmaceutical industry to generate a third generation-style technology roadmap for TSensor Systems. First we identify drivers and consortia. We then identify relevant technology components, namely multiple root technologies, multiple unit cells, multiple

  11. Roadmap on neurophotonics

    Science.gov (United States)

    Cho, Yong Ku; Zheng, Guoan; Augustine, George J; Hochbaum, Daniel; Cohen, Adam; Knöpfel, Thomas; Pisanello, Ferruccio; Pavone, Francesco S; Vellekoop, Ivo M; Booth, Martin J; Hu, Song; Zhu, Jiang; Chen, Zhongping; Hoshi, Yoko

    2017-01-01

    Mechanistic understanding of how the brain gives rise to complex behavioral and cognitive functions is one of science’s grand challenges. The technical challenges that we face as we attempt to gain a systems-level understanding of the brain are manifold. The brain’s structural complexity requires us to push the limit of imaging resolution and depth, while being able to cover large areas, resulting in enormous data acquisition and processing needs. Furthermore, it is necessary to detect functional activities and ‘map’ them onto the structural features. The functional activity occurs at multiple levels, using electrical and chemical signals. Certain electrical signals are only decipherable with sub-millisecond timescale resolution, while other modes of signals occur in minutes to hours. For these reasons, there is a wide consensus that new tools are necessary to undertake this daunting task. Optical techniques, due to their versatile and scalable nature, have great potentials to answer these challenges. Optical microscopy can now image beyond the diffraction limit, record multiple types of brain activity, and trace structural features across large areas of tissue. Genetically encoded molecular tools opened doors to controlling and detecting neural activity using light in specific cell types within the intact brain. Novel sample preparation methods that reduce light scattering have been developed, allowing whole brain imaging in rodent models. Adaptive optical methods have the potential to resolve images from deep brain regions. In this roadmap article, we showcase a few major advances in this area, survey the current challenges, and identify potential future needs that may be used as a guideline for the next steps to be taken. PMID:28386392

  12. Strategic planning for molten carbonate fuel cell development and commercialization

    Science.gov (United States)

    Williams, M. C.; Mayfield, M. J.

    The molten carbonate fuel cell (MCFC), a high-temperature fuel cell, is a promising energy conversion product for generating electricity. Natural gas availability appears to play a key role in MCFC commercialization; natural gas MCFC and Integrated Gasification MCFC (IGMCFC) are emerging power generation options that are responsive to requirements of Clean Air Act amendments and to guidance in National Energy Strategy. Goal of DOE IGMCFC program is to demonstrate the commercial readiness of this technology by the year 2010. DOE MCFC development objectives and planned activities are outlined.

  13. Alumina Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2002-02-01

    The Alumina Technology Roadmap outlines a comprehensive long-term research and development plan that defines the industry's collective future and establishes a clear pathway forward. It emphasizes twelve high-priority R&D areas deemed most significant in addressing the strategic goals.

  14. Roadmap of Infinite Results

    DEFF Research Database (Denmark)

    Srba, Jiří

    2002-01-01

    This paper provides a comprehensive summary of equivalence checking results for infinite-state systems. References to the relevant papers will be updated continuously according to the development in the area. The most recent version of this document is available from the web-page http://www.brics.dk/~srba/roadmap....

  15. Materials Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-08-01

    Roadmap identifying the efforts of the Materials Technical Team (MTT) to focus primarily on reducing the mass of structural systems such as the body and chassis in light-duty vehicles (including passenger cars and light trucks) which enables improved vehicle efficiency regardless of the vehicle size or propulsion system employed.

  16. The 2017 Magnetism Roadmap

    Science.gov (United States)

    Sander, D.; Valenzuela, S. O.; Makarov, D.; Marrows, C. H.; Fullerton, E. E.; Fischer, P.; McCord, J.; Vavassori, P.; Mangin, S.; Pirro, P.; Hillebrands, B.; Kent, A. D.; Jungwirth, T.; Gutfleisch, O.; Kim, C. G.; Berger, A.

    2017-09-01

    Building upon the success and relevance of the 2014 Magnetism Roadmap, this 2017 Magnetism Roadmap edition follows a similar general layout, even if its focus is naturally shifted, and a different group of experts and, thus, viewpoints are being collected and presented. More importantly, key developments have changed the research landscape in very relevant ways, so that a novel view onto some of the most crucial developments is warranted, and thus, this 2017 Magnetism Roadmap article is a timely endeavour. The change in landscape is hereby not exclusively scientific, but also reflects the magnetism related industrial application portfolio. Specifically, Hard Disk Drive technology, which still dominates digital storage and will continue to do so for many years, if not decades, has now limited its footprint in the scientific and research community, whereas significantly growing interest in magnetism and magnetic materials in relation to energy applications is noticeable, and other technological fields are emerging as well. Also, more and more work is occurring in which complex topologies of magnetically ordered states are being explored, hereby aiming at a technological utilization of the very theoretical concepts that were recognised by the 2016 Nobel Prize in Physics. Given this somewhat shifted scenario, it seemed appropriate to select topics for this Roadmap article that represent the three core pillars of magnetism, namely magnetic materials, magnetic phenomena and associated characterization techniques, as well as applications of magnetism. While many of the contributions in this Roadmap have clearly overlapping relevance in all three fields, their relative focus is mostly associated to one of the three pillars. In this way, the interconnecting roles of having suitable magnetic materials, understanding (and being able to characterize) the underlying physics of their behaviour and utilizing them for applications and devices is well illustrated, thus giving an

  17. The 2017 Magnetism Roadmap

    International Nuclear Information System (INIS)

    Sander, D; Valenzuela, S O; Makarov, D

    2017-01-01

    Building upon the success and relevance of the 2014 Magnetism Roadmap, this 2017 Magnetism Roadmap edition follows a similar general layout, even if its focus is naturally shifted, and a different group of experts and, thus, viewpoints are being collected and presented. More importantly, key developments have changed the research landscape in very relevant ways, so that a novel view onto some of the most crucial developments is warranted, and thus, this 2017 Magnetism Roadmap article is a timely endeavour. The change in landscape is hereby not exclusively scientific, but also reflects the magnetism related industrial application portfolio. Specifically, Hard Disk Drive technology, which still dominates digital storage and will continue to do so for many years, if not decades, has now limited its footprint in the scientific and research community, whereas significantly growing interest in magnetism and magnetic materials in relation to energy applications is noticeable, and other technological fields are emerging as well. Also, more and more work is occurring in which complex topologies of magnetically ordered states are being explored, hereby aiming at a technological utilization of the very theoretical concepts that were recognised by the 2016 Nobel Prize in Physics. Given this somewhat shifted scenario, it seemed appropriate to select topics for this Roadmap article that represent the three core pillars of magnetism, namely magnetic materials, magnetic phenomena and associated characterization techniques, as well as applications of magnetism. While many of the contributions in this Roadmap have clearly overlapping relevance in all three fields, their relative focus is mostly associated to one of the three pillars. In this way, the interconnecting roles of having suitable magnetic materials, understanding (and being able to characterize) the underlying physics of their behaviour and utilizing them for applications and devices is well illustrated, thus giving an

  18. Roadmapping as a Tool for Renewing Regulatory Practices

    DEFF Research Database (Denmark)

    Borch, Kristian; Norus, Jesper

    The aim of this paper is to explore technological roadmaps to identify key issues concerning the development and utilization of stem cells. From a review of the political decision making processes in three countries, Denmark, the Netherlands, and Germany we suggest that technological roadmapping...... based on the content and visions of the technologies in question. In the conclusion we discuss that the positive side effect of such a shift in the regulatory paradigm is that technological roadmapping can be used as a planning tool to deal with priorities in the health care system when the technologies...

  19. A roadmap towards personalized immunology.

    Science.gov (United States)

    Delhalle, Sylvie; Bode, Sebastian F N; Balling, Rudi; Ollert, Markus; He, Feng Q

    2018-01-01

    Big data generation and computational processing will enable medicine to evolve from a "one-size-fits-all" approach to precise patient stratification and treatment. Significant achievements using "Omics" data have been made especially in personalized oncology. However, immune cells relative to tumor cells show a much higher degree of complexity in heterogeneity, dynamics, memory-capability, plasticity and "social" interactions. There is still a long way ahead on translating our capability to identify potentially targetable personalized biomarkers into effective personalized therapy in immune-centralized diseases. Here, we discuss the recent advances and successful applications in "Omics" data utilization and network analysis on patients' samples of clinical trials and studies, as well as the major challenges and strategies towards personalized stratification and treatment for infectious or non-communicable inflammatory diseases such as autoimmune diseases or allergies. We provide a roadmap and highlight experimental, clinical, computational analysis, data management, ethical and regulatory issues to accelerate the implementation of personalized immunology.

  20. Roadmap 2030: The U.S. Concrete Industry Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2002-12-01

    Roadmap 2030: The U.S. Concrete Industry Technology Roadmap tracks the eight goals published in the American Concrete Institute Strategic Development Council's Vision 2030: A Vision for the U.S. Concrete Industry. Roadmap 2030 highlights existing state-of-the-art technologies and emerging scientific advances that promise high potential for innovation, and predicts future technological needs. It defines enabling research opportunities and proposes areas where governmental-industrial-academic partnerships can accelerate the pace of development. Roadmap 2030 is a living document designed to continually address technical, institutional, and market changes.

  1. Technology Roadmaps: Smart Grids

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    The development of Technology Roadmaps: Smart Grids -- which the IEA defines as an electricity network that uses digital and other advanced technologies to monitor and manage the transport of electricity from all generation sources to meet the varying electricity demands of end users -- is essential if the global community is to achieve shared goals for energy security, economic development and climate change mitigation. Unfortunately, existing misunderstandings of exactly what smart grids are and the physical and institutional complexity of electricity systems make it difficult to implement smart grids on the scale that is needed. This roadmap sets out specific steps needed over the coming years to achieve milestones that will allow smart grids to deliver a clean energy future.

  2. OHVT technology roadmap

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The Office of Heavy Vehicle Technologies (OHVT) Technology Roadmap presents the OHVT multiyear program plan. It was developed in response to recommendations by DOE`s heavy vehicle industry customers, including truck and bus manufacturers, diesel engine manufacturers, fuel producers, suppliers to these industries, and the trucking industry. The technical plan is presented for three classes of trucks: (1) class 7-8 (large, on-highway trucks); (2) class 3-6 (medium duty trucks); and (3) class 1-2 (pickups, vans, and sport utility vehicles). The Roadmap documents program goals, technical targets, and technical approaches. Issues addressed include engine efficiency, fuel efficiency, power requirements, emissions, and fuel flexibility. 8 figs., 9 tabs.

  3. National Hydrogen Roadmap Workshop Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    None

    2002-04-01

    This document summarizes the presentations and suggestions put forth by officials, industry experts and policymakers in their efforts to come together to develop a roadmap for America''s clean energy future and outline the key barriers and needs to achieve the hydrogen vision. The National Hydrogen Roadmap Workshop was held April 2-3, 2002. These proceedings were compiled into a formal report, The National Hydrogen Energy Roadmap, which is also available online.

  4. Assessment of commercial prospects of molten carbonate fuel cells

    Science.gov (United States)

    Dicks, Andrew; Siddle, Angie

    The commercial prospects of molten carbonate fuel cells have been evaluated. Market applications, and the commercial criteria that the MCFC will need to satisfy for these applications, were identified through interviews with leading MCFC developers. Strengths, weaknesses, opportunities and threats (SWOT) analyses were carried out to critically evaluate the prospects for commercialisation. There are many competing technologies, but it is anticipated that MCFCs can make significant penetration into markets where their attributes, such as quality of power, low emissions and availability, give them a leading position in comparison with, for example, engine and turbine-based power generation systems. Analysis suggests that choosing the size for MCFC plant is more important than the target market sector/niche. Opportunities will exist in many market sectors, though the commercial market would be easier to penetrate initially. Developers are optimistic about the commercial prospects for the MCFC. Most believe that early commercial MCFC plants may start to appear in the first decade of the next century, the earliest date suggested for initial market entry being 2002.

  5. The NASA Astrobiology Roadmap.

    Science.gov (United States)

    Des Marais, David J; Nuth, Joseph A; Allamandola, Louis J; Boss, Alan P; Farmer, Jack D; Hoehler, Tori M; Jakosky, Bruce M; Meadows, Victoria S; Pohorille, Andrew; Runnegar, Bruce; Spormann, Alfred M

    2008-08-01

    The NASA Astrobiology Roadmap provides guidance for research and technology development across the NASA enterprises that encompass the space, Earth, and biological sciences. The ongoing development of astrobiology roadmaps embodies the contributions of diverse scientists and technologists from government, universities, and private institutions. The Roadmap addresses three basic questions: how does life begin and evolve, does life exist elsewhere in the universe, and what is the future of life on Earth and beyond? Seven Science Goals outline the following key domains of investigation: understanding the nature and distribution of habitable environments in the universe, exploring for habitable environments and life in our own Solar System, understanding the emergence of life, determining how early life on Earth interacted and evolved with its changing environment, understanding the evolutionary mechanisms and environmental limits of life, determining the principles that will shape life in the future, and recognizing signatures of life on other worlds and on early Earth. For each of these goals, Science Objectives outline more specific high priority efforts for the next three to five years. These eighteen objectives are being integrated with NASA strategic planning.

  6. Commercialization of proton exchange membrane (PEM) fuel cell technology

    International Nuclear Information System (INIS)

    Goel, N.; Pant, A.; Sera, G.

    1995-01-01

    The MCTTC performed a market assessment for PEM Fuel Cells for terrestrial applications for the Center for Space Power (CSP). The purpose of the market assessment was to gauge the market and commercial potential for PEM fuel cell technology. Further, the market assessment was divided into subsections of technical and market overview, competitive environment, political environment, barriers to market entry, and keys to market entry. The market assessment conducted by the MCTTC involved both secondary and primary research. The primary target markets for PEM fuel cells were transportation and utilities in the power range of 10 kW to 100 kW. The fuel cell vehicle market size was estimated under a pessimistic scenario and an optimistic scenario. The estimated size of the fuel cell vehicle market in dollar terms for the year 2005 is $17.3 billion for the pessimistic scenario and $34.7 billion for the optimistic scenario. The fundamental and applied research funded and conducted by the National Aeronautics and Space Administration (NASA) and DOE in the area of fuel cells presents an excellent opportunity to commercialize dual-use technology and enhance U.S. business competitiveness. copyright 1995 American Institute of Physics

  7. Fuel cell commercialization: The key to a hydrogen economy

    Science.gov (United States)

    Zegers, P.

    With the current level of global oil production, oil reserves will be sufficient for 40 years. However, due to the fact that the global GDP will have increased by a factor seven in 2050, oil reserves are likely to be exhausted in a much shorter time period. The EU and car industry aim at a reduction of the consumption of oil, at energy savings (with a key role for fuel cells) and an increased use of hydrogen from natural gas and, possibly, coal, in the medium term. The discovery of huge methane resources as methane hydrates (20 times those of oil, gas and coal together) in oceans at 1000-3000 m depth could be of major importance. In the long term, the EU aims at a renewable energy-based energy supply. The European Hydrogen and Fuel Cell Technology Platform is expected to play a major role in bringing about a hydrogen economy. The availability of commercial fuel cells is here a prerequisite. However, after many years of research, fuel cells have not yet been commercialized. If they will not succeed to enter the market within 5 years there is a real danger that activities aiming at a hydrogen society will peter out. In a hydrogen strategy, high priority should therefore be given to actions which will bring about fuel cell commercialization within 5 years. They should include the identification of fuel cell types and (niche) markets which are most favorable for a rapid market introduction. These actions should include focused short-term RTD aiming at cost reduction and increased reliability.

  8. A roadmap towards personalized immunology

    DEFF Research Database (Denmark)

    Delhalle, Sylvie; Bode, Sebastian F N; Balling, Rudi

    2018-01-01

    Big data generation and computational processing will enable medicine to evolve from a "one-size-fits-all" approach to precise patient stratification and treatment. Significant achievements using "Omics" data have been made especially in personalized oncology. However, immune cells relative......-centralized diseases. Here, we discuss the recent advances and successful applications in "Omics" data utilization and network analysis on patients' samples of clinical trials and studies, as well as the major challenges and strategies towards personalized stratification and treatment for infectious or non......-communicable inflammatory diseases such as autoimmune diseases or allergies. We provide a roadmap and highlight experimental, clinical, computational analysis, data management, ethical and regulatory issues to accelerate the implementation of personalized immunology....

  9. Education Roadmap for Mining Professionals

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2002-12-01

    This document represents the roadmap for education in the U.S. mining industry. It was developed based on the results of an Education Roadmap Workshop sponsored by the National Mining Association in conjunction with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Office of Industrial Technologies. The Workshop was held February 23, 2002 in Phoenix, Arizona.

  10. Electrochemical Energy Storage Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    This U.S. DRIVE electrochemical energy storage roadmap describes ongoing and planned efforts to develop electrochemical energy storage technologies for plug-in electric vehicles (PEVs). The Energy Storage activity comprises a number of research areas (including advanced materials research, cell level research, battery development, and enabling R&D which includes analysis, testing and other activities) for advanced energy storage technologies (batteries and ultra-capacitors).

  11. Current status of the TSensor systems roadmap

    OpenAIRE

    Walsh, Steven Thomas; Bryzek, Janusz; Pisano, Albert P.

    2014-01-01

    We apply our work from the contemporary pharmaceutical industry to generate a third generation-style technology roadmap for TSensor Systems. First we identify drivers and consortia. We then identify relevant technology components, namely multiple root technologies, multiple unit cells, multiple critical dimensions, strict boundary conditions constraining innovations and products, a heightened importance of drivers, and a more prominent role for consortia. These components include chips and na...

  12. MAPSIT and a Roadmap for Lunar and Planetary Spatial Data Infrastructure

    Science.gov (United States)

    Radebaugh, J.; Archinal, B.; Beyer, R.; DellaGiustina, D.; Fassett, C.; Gaddis, L.; Hagerty, J.; Hare, T.; Laura, J.; Lawrence, S. J.; Mazarico, E.; Naß, A.; Patthoff, A.; Skinner, J.; Sutton, S.; Thomson, B. J.; Williams, D.

    2017-10-01

    We describe MAPSIT, and the development of a roadmap for lunar and planetary SDI, based on previous relevant documents and community input, and consider how to best advance lunar science, exploration, and commercial development.

  13. Technology Roadmaps: Wind Energy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    Wind energy is perhaps the most advanced of the 'new' renewable energy technologies, but there is still much work to be done. This roadmap identifies the key tasks that must be undertaken in order to achieve a vision of over 2 000 GW of wind energy capacity by 2050. Governments, industry, research institutions and the wider energy sector will need to work together to achieve this goal. Best technology and policy practice must be identified and exchanged with emerging economy partners, to enable the most cost-effective and beneficial development.

  14. Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-08-01

    This report identifies the commercial and near-commercial (emerging) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies Program in the Office of Energy Efficiency and Renewable Energy.

  15. Technology Roadmaps: How2Guide for Wind Energy Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-03-01

    Whether in OECD, emerging or developing country economies, governments are increasingly looking to diversify their energy mix beyond simply fossil fuels. While wind energy is developing towards a mainstream, competitive and reliable technology, a range of barriers can delay progress, such as financing, grid integration, social acceptance and aspects of planning processes. National and regional technology roadmaps can play a key role in supporting wind energy development and implementation, helping countries to identify priorities and pathways tailored to local resources and markets. Recognising this, the IEA has started the How2Guides - a new series co-ordinated by the International Low-Carbon Energy Technology Platform to address the need for more focused guidance in the development of national roadmaps, or strategies, for specific low-carbon technologies. This builds on the success of the IEA global technology roadmap series and responds to a growing number of requests for IEA guidance to adapt the findings of the IEA global technology roadmaps to national circumstances. A successful roadmap contains a clear statement of the desired outcome, followed by a specific pathway for reaching it. The How2Guide for Wind Energy builds on the IEA well established methodology for roadmap development and shares wind specific recommendations on how to address the four phases to developing and implementing a wind energy roadmap: Planning; Visioning; Development; and Implementation. The manual also offers menus of recommendations on policy and technical options for deployment of utility-scale wind energy installations. A matrix of barriers-versus-realistic solutions options is cross-listed with considerations such as planning, development, electricity market and system, infrastructure, and finance and economics. Drawing on several case studies from around the globe, as well as on the IEA Technology Roadmap for Wind Energy, the How2Guide for Wind Energy it is intended as a

  16. Heat Roadmap Europe

    DEFF Research Database (Denmark)

    David, Andrei; Mathiesen, Brian Vad; Averfalk, Helge

    2017-01-01

    The Heat Roadmap Europe (HRE) studies estimated a potential increase of the district heating (DH) share to 50% of the entire heat demand by 2050, with approximately 25–30% of it being supplied using large-scale electric heat pumps. This study builds on this potential and aims to document that suc......The Heat Roadmap Europe (HRE) studies estimated a potential increase of the district heating (DH) share to 50% of the entire heat demand by 2050, with approximately 25–30% of it being supplied using large-scale electric heat pumps. This study builds on this potential and aims to document......, refrigerants, efficiency and types of operation of 149 units with 1580 MW of thermal output, the study further uses this data to analyze if the deployment of this technology on a large-scale is possible in other locations in Europe. It finally demonstrates that the technical level of the existing heat pumps...... is mature enough to make them suitable for replication in other locations in Europe....

  17. Direct fuel cell power plants: the final steps to commercialization

    Science.gov (United States)

    Glenn, Donald R.

    Since the last paper presented at the Second Grove Fuel Cell Symposium, the Energy Research Corporation (ERC) has established two commercial subsidiaries, become a publically-held firm, expanded its facilities and has moved the direct fuel cell (DFC) technology and systems significantly closer to commercial readiness. The subsidiaries, the Fuel Cell Engineering Corporation (FCE) and Fuel Cell Manufacturing Corporation (FCMC) are perfecting their respective roles in the company's strategy to commercialize its DFC technology. FCE is the prime contractor for the Santa Clara Demonstration and is establishing the needed marketing, sales, engineering, and servicing functions. FCMC in addition to producing the stacks and stack modules for the Santa Clara demonstration plant is now upgrading its production capability and product yields, and retooling for the final stack scale-up for the commercial unit. ERC has built and operated the tallest and largest capacities-to-date carbonate fuel cell stacks as well as numerous short stacks. While most of these units were tested at ERC's Danbury, Connecticut (USA) R&D Center, others have been evaluated at other domestic and overseas facilities using a variety of fuels. ERC has supplied stacks to Elkraft and MTU for tests with natural gas, and RWE in Germany where coal-derived gas were used. Additional stack test activities have been performed by MELCO and Sanyo in Japan. Information from some of these activities is protected by ERC's license arrangements with these firms. However, permission for limited data releases will be requested to provide the Grove Conference with up-to-date results. Arguably the most dramatic demonstration of carbonate fuel cells in the utility-scale, 2 MW power plant demonstration unit, located in the City of Santa Clara, California. Construction of the unit's balance-of-plant (BOP) has been completed and the installed equipment has been operationally checked. Two of the four DFC stack sub-modules, each

  18. Technology Roadmaps: China Wind Energy Development Roadmap 2050

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    The report shows how China, already the world's largest wind market, could reach 1 000 GW of wind power by the middle of the century, an achievement that would reduce carbon dioxide emissions by 1.5 gigatonnes per year, or roughly equivalent to the combined CO2 emissions of Germany, France and Italy in 2009. The China Wind Energy Roadmap is the first national roadmap that has been developed by a country with IEA support, drawing from its global roadmap series.

  19. Power Tower Technology Roadmap and cost reduction plan.

    Energy Technology Data Exchange (ETDEWEB)

    Mancini, Thomas R.; Gary, Jesse A. (U.S. Department of Energy); Kolb, Gregory J.; Ho, Clifford Kuofei

    2011-04-01

    Concentrating solar power (CSP) technologies continue to mature and are being deployed worldwide. Power towers will likely play an essential role in the future development of CSP due to their potential to provide dispatchable solar electricity at a low cost. This Power Tower Technology Roadmap has been developed by the U.S. Department of Energy (DOE) to describe the current technology, the improvement opportunities that exist for the technology, and the specific activities needed to reach the DOE programmatic target of providing competitively-priced electricity in the intermediate and baseload power markets by 2020. As a first step in developing this roadmap, a Power Tower Roadmap Workshop that included the tower industry, national laboratories, and DOE was held in March 2010. A number of technology improvement opportunities (TIOs) were identified at this workshop and separated into four categories associated with power tower subsystems: solar collector field, solar receiver, thermal energy storage, and power block/balance of plant. In this roadmap, the TIOs associated with power tower technologies are identified along with their respective impacts on the cost of delivered electricity. In addition, development timelines and estimated budgets to achieve cost reduction goals are presented. The roadmap does not present a single path for achieving these goals, but rather provides a process for evaluating a set of options from which DOE and industry can select to accelerate power tower R&D, cost reductions, and commercial deployment.

  20. Heat Roadmap Europe 1

    DEFF Research Database (Denmark)

    Connolly, David; Mathiesen, Brian Vad; Østergaard, Poul Alberg

    2012-01-01

    Heat Roadmap Europe (Pre-study 1) investigates the role of district heating in the EU27 energy system by mapping local conditions across Europe, identifying the potential for district heating expansion, and subsequently simulating the potential resource in an hourly model of the EU27 energy system....... In 2010, approximately 12% of the space heating demand in Europe is met by district heating, but in this study four alternative scenarios are considered for the EU27 energy system: 1. 2010 with 30% district heating 2. 2010 with 50% district heating 3. 2030 with 30% district heating 4. 2050 with 50......% district heating These scenarios are investigated in two steps. Firstly, district heating replaces individual boilers by converting condensing power plants to combined heat and power plants (CHP) to illustrate how district heating improves the overall efficiency of the energy system. In the second step...

  1. Heat Roadmap Europe

    DEFF Research Database (Denmark)

    Connolly, David; Lund, Henrik; Mathiesen, Brian Vad

    2014-01-01

    indicate that with district heating, the EU energy system will be able to achieve the same reductions in primary energy supply and carbon dioxide emissions as the existing alternatives proposed. However, with district heating these goals can be achieved at a lower cost, with heating and cooling costs......Six different strategies have recently been proposed for the European Union (EU) energy system in the European Commission's report, Energy Roadmap 2050. The objective for these strategies is to identify how the EU can reach its target of an 80% reduction in annual greenhouse gas emissions in 2050...... compared to 1990 levels. None of these scenarios involve the large-scale implementation of district heating, but instead they focus on the electrification of the heating sector (primarily using heat pumps) and/or the large-scale implementation of electricity and heat savings. In this paper, the potential...

  2. Technology Roadmap: Hydropower

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    Hydropower could double its contribution by 2050, reaching 2,000 GW of global capacity and over 7,000 TWh. This achievement, driven primarily by the quest of clean electricity, could prevent annual emissions of up to 3 billion tonnes of CO2 from fossil-fuel plants. The bulk of this growth would come from large plants in emerging economies and developing countries. Hydroelectricity’s many advantages include reliability, proven technology, large storage capacity, and very low operating and maintenance costs. Hydropower is highly flexible, a precious asset for electricity network operators, especially given rapid expansion of variable generation from other renewable energy technologies such as wind power and photovoltaics. Many hydropower plants also provide flood control, irrigation, navigation and freshwater supply. The technology roadmap for Hydropower details action needed from policy makers to allow hydroelectric production to double, and addresses necessary conditions, including resolving environmental issues and gaining public acceptance.

  3. Technology Roadmaps: Nuclear Energy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This nuclear energy roadmap has been prepared jointly by the IEA and the OECD Nuclear Energy Agency (NEA). Unlike most other low-carbon energy sources, nuclear energy is a mature technology that has been in use for more than 50 years. The latest designs for nuclear power plants build on this experience to offer enhanced safety and performance, and are ready for wider deployment over the next few years. Several countries are reactivating dormant nuclear programmes, while others are considering nuclear for the first time. China in particular is already embarking on a rapid nuclear expansion. In the longer term, there is great potential for new developments in nuclear energy technology to enhance nuclear's role in a sustainable energy future.

  4. Forest Products Industry Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-04-01

    This document describes the forest products industry's research and development priorities. The original technology roadmap published by the industry in 1999 and was most recently updated in April 2010.

  5. Hydrogen Production Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The Hydrogen Production Technical Team Roadmap identifies research pathways leading to hydrogen production technologies that produce near-zero net greenhouse gas (GHG) emissions from highly efficient and diverse renewable energy sources. This roadmap focuses on initial development of the technologies, identifies their gaps and barriers, and describes activities by various U.S. Department of Energy (DOE) offices to address the key issues and challenges.

  6. Technology Roadmapping for Waste Management

    International Nuclear Information System (INIS)

    Bray, O.

    2003-01-01

    Technology roadmapping can be an effective strategic technology planning tool. This paper describes a process for customizing a generic technology roadmapping process. Starting with a generic process reduces the learning curve and speeds up the roadmap development. Similarly, starting with a generic domain model provides leverage across multiple applications or situations within the domain. A process that combines these two approaches facilitates identifying technology gaps and determining common core technologies that can be reused for multiple applications or situations within the domain. This paper describes both of these processes and how they can be integrated. A core team and a number of technology working groups develop the technology roadmap, which includes critical system requirements and targets, technology areas and metrics for each area, and identifies and evaluates possible technology alternatives to recommend the most appropriate ones to pursue. A generalized waste management model, generated by considering multiple situations or applications in terms of a generic waste management model, provides the domain requirements for the technology roadmapping process. Finally, the paper discusses lessons learns from a number of roadmapping projects

  7. Commercial Development Of Ovonic Thin Film Solar Cells

    Science.gov (United States)

    Ovshinsky, Stanford R.

    1983-09-01

    One square foot Ovonic amorphous photovoltaic devices are already in commercial production and are manufactured through a continuous web process. The next levels of commercialization required to achieve a large-volume power market will be discussed, and the device specifications correlated with the chemical and electronic properties of the materials that we are developing to achieve even higher efficiencies. It has been long considered a utopian dream to harness the energy of the sun to create electricity that would be competitive in cost to that produced from the conventional sources of energy such as oil, gas, and uranium. The impact on our society of stand-alone power generators without moving parts using the continually available, ubiquitous energy of the sun could certainly lead to a new age with consequences comparable to the first introduction of electricity which greatly accelerated the Industrial Revolution. Low cost, nonpolluting energy not dependent upon or limited by transmission costs could again make DC electricity a realistic option. The relatively young field of photovoltaics suffers from certain dogmas that are just now being questioned. For example, it is thought by many that solar cells utilizing crys-talline materials have inherently higher efficiencies than those using amorphous materials, and that somehow crystalline solar cells, whether fabricated from single crystals or polycrystalline material, in round or rectangular geometries, grown from the melt or by a rib-bon process, can be reduced in cost sufficiently that the economics become attractive enough for large-scale terrestrial generation of power. In this paper, we shall show that amorphous materials can have much higher efficiencies than do crystalline and that the answer to our power generation needs lies not in crystalline but in amorphous technology. At Energy Conversion Devices, Inc. (ECD), we have designed and built a production machine (described by my colleague, Dr. Izu, in a

  8. The European Roadmap to Fussion Electricity

    International Nuclear Information System (INIS)

    Romanelli, Francesco

    2014-01-01

    With the reduction of CO 2 emissions driving future energy policy, fusion can start market penetration around 2050 with up to 30% of electricity production by 2100. This requires an ambitious, yet realistic roadmap towards the demonstration of electricity production by 2050. This talk describes the main technical challenges on the path to fusion energy. For all of the challenges candidate solutions have been developed and the goal of the programme is now to demonstrate that they will also work at the scale of a reactor. The roadmap has been developed within a goal-oriented approach articulated in eight different Missions. For each Mission the critical aspects for reactor application, the risks and risk mitigation stretegies, the level of readiness now and after ITER and the gaps in the programme have been examined with involvement of experts from ITER International Organization, Fusion for Energy, EFDA Close Support Unites and EFDA Associates. High-level work packages for the roadmap implementation have been prepared and the resources evaluated. ITER is the key facility in the roadmap and its success represents the most important overarching objectives of the EU programme. A demonstration fusion power plant (DEMO), producing net electricitiy for the grid at the level of a few hundreds MW is foreseen to start operation in the early 2040s. Following ITER, it will be the single step to a commercial fusion power plant. Industry must be involved early in the DEMO definition and design. The evolution of the programme requires that industry progressively shifts its role from that of provider of high-tech components to that of driver of the fusion development. Industry must be able to take full responsibility for the commercial fusion power plan after successful DEMO operation. For this reason, DEMO cannot be defined and designed by research laboratories alone, but requires the full involvement of industry in all technological and systems aspects of the design. Europe

  9. A roadmap for innovation.

    Science.gov (United States)

    Hodgetts, Timothy J

    2014-06-01

    Medicine has historically advanced during conflict, but military medical services have consistently regressed during peace. As over a decade of campaigning in Iraq and Afghanistan draws to a close, securing the legacy of hard won clinical lessons and retaining flexibility to adapt to new patterns of illness and injury during contingency is critical. Central to sustaining exceptional outcomes for future operations and to maintaining the current position of the Defence Medical Services as providers of clinical excellence is retaining the capability to innovate. This capability must extend across the spectrum of clinical innovation-concepts, guidelines, equipment (invention and adoption), curricula (design, assessment and refinement), research and Defence diplomacy. To achieve this requires a strategy, a 'roadmap', with a clear vision, end state and centres of gravity (core strengths that must be protected). The direction for innovation will be guided by emergent analysis of the future character of military medicine. Success will be determined by ensuring the conditions are met to protect and enhance the existing 'winning culture'. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  10. Technology Roadmap: Energy Storage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-03-01

    Energy storage technologies are valuable components in most energy systems and could be an important tool in achieving a low-carbon future. These technologies allow for the decoupling of energy supply and demand, in essence providing a valuable resource to system operators. There are many cases where energy storage deployment is competitive or near-competitive in today's energy system. However, regulatory and market conditions are frequently ill-equipped to compensate storage for the suite of services that it can provide. Furthermore, some technologies are still too expensive relative to other competing technologies (e.g. flexible generation and new transmission lines in electricity systems). One of the key goals of this new roadmap is to understand and communicate the value of energy storage to energy system stakeholders. This will include concepts that address the current status of deployment and predicted evolution in the context of current and future energy system needs by using a ''systems perspective'' rather than looking at storage technologies in isolation.

  11. Catalyst technology roadmap report

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, N.B.

    1997-06-01

    This report outlines the future technology needs of the Chemical Industry in the area of catalysis and is a continuation of the process that produced the report Technology Vision 2020: The U.S. Chemical Industry and the Council for Chemical Research`s (CCR) Chemical Synthesis Team follow-up work in chemical synthesis. Vision 2020 developed a 25-year vision for the chemical industry and outlined the challenges to be addressed in order to achieve this vision. This report, which outlines the catalysis technology roadmap, is based on the output of the CCR`s Chemical Synthesis Team, plus a workshop held March -20-21, 1997, which included about 50 participants, with catalysis experts from industry, academia, and government. It is clear that all participants view catalysis as a fundamental driver to the 0274 economic and environmental viability of the chemical industry. Advances in catalytic science and technology are among the most crucial challenges to achieving the goals of the chemical industry advanced in Vision 2020.

  12. Solar-electric power: The U.S. photovoltaic industry roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2003-01-01

    To meet this challenge, we — the U.S.-based PV industry — have developed this roadmap as a guide for building our domestic industry, ensuring U.S. technology ownership, and implementing a sound commercialization strategy that will yield significant benefits at minimal cost. Putting the roadmap into action will call for reasonable and consistent co-investment by our industry and government in research and technology development.

  13. Concentrating Solar Power. Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-10-15

    Concentrating solar power can contribute significantly to the world's energy supply. As shown in this roadmap, this decade is a critical window of opportunity during which CSP could become a competitive source of electrical power to meet peak and intermediate loads in the sunniest parts of the world. This roadmap identifies technology, economy and policy goals and milestones needed to support the development and deployment of CSP, as well as ongoing advanced research in CSF. It also sets out the need for governments to implement strong, balanced policies that favour rapid technological progress, cost reductions and expanded industrial manufacturing of CSP equipment to enable mass deployment. Importantly, this roadmap also establishes a foundation for greater international collaboration. The overall aim of this roadmap is to identify actions required - on the part of all stakeholders - to accelerate CSP deployment globally. Many countries, particularly in emerging regions, are only just beginning to develop CSP. Accordingly, milestone dates should be considered as indicative of urgency, rather than as absolutes. This roadmap is a work in progress. As global CSP efforts advance and an increasing number of CSP applications are developed, new data will provide the basis for updated analysis. The IEA will continue to track the evolution of CSP technology and its impacts on markets, the power sector and regulatory environments, and will update its analysis and set additional tasks and milestones as new learning comes to light.

  14. Electronic Safety Resource Tools -- Supporting Hydrogen and Fuel Cell Commercialization

    Energy Technology Data Exchange (ETDEWEB)

    Barilo, Nick F.

    2014-09-29

    The Pacific Northwest National Laboratory (PNNL) Hydrogen Safety Program conducted a planning session in Los Angeles, CA on April 1, 2014 to consider what electronic safety tools would benefit the next phase of hydrogen and fuel cell commercialization. A diverse, 20-person team led by an experienced facilitator considered the question as it applied to the eight most relevant user groups. The results and subsequent evaluation activities revealed several possible resource tools that could greatly benefit users. The tool identified as having the greatest potential for impact is a hydrogen safety portal, which can be the central location for integrating and disseminating safety information (including most of the tools identified in this report). Such a tool can provide credible and reliable information from a trustworthy source. Other impactful tools identified include a codes and standards wizard to guide users through a series of questions relating to application and specific features of the requirements; a scenario-based virtual reality training for first responders; peer networking tools to bring users from focused groups together to discuss and collaborate on hydrogen safety issues; and a focused tool for training inspectors. Table ES.1 provides results of the planning session, including proposed new tools and changes to existing tools.

  15. The GRIP method for collaborative roadmapping workshops

    DEFF Research Database (Denmark)

    Piirainen, Kalle

    2015-01-01

    Technology roadmapping is a well-known tool for technology management, but practical advice for facilitating collaborative roadmapping workshops is relatively scarce. To cater for this need, we have designed a method for collaborative roadmapping, dubbed the GRIP method, for facilitating group work...

  16. A Technology Roadmap for Strategic Development of Enhanced Geothermal Systems

    Energy Technology Data Exchange (ETDEWEB)

    Ziagos, John [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Phillips, Benjamin R. [SRA International, Inc. and Geothermal Technologies Office, Washington, DC (United States); Boyd, Lauren [Geothermal Technologies Office, Washington, DC (United States); Jelacic, Allan [SRA International, Inc., Washington, DC (United States); Stillman, Greg [Geothermal Technologies Office, Washington, DC (United States); Hass, Eric [U.S. DOE, Golden, CO (United States)

    2013-02-13

    Realization of EGS development would make geothermal a significant contender in the renewable energy portfolio, on the order of 100+ GWe in the United States alone. While up to 90% of the geothermal power resource in the United States is thought to reside in Enhanced Geothermal Systems (EGS), hurdles to commercial development still remain. The Geothermal Technologies Office, U.S. Department of Energy (DOE), began in 2011 to outline opportunities for advancing EGS technologies on five- to 20-year timescales, with community input on the underlying technology needs that will guide research and ultimately determine commercial success for EGS. This report traces DOE's research investments, past and present, and ties them to these technology needs, forming the basis for an EGS Technology Roadmap to help guide future DOE research. This roadmap is currently open for public comment. Send your comments to geothermal@ee.doe.gov.

  17. Roadmap on optical security

    NARCIS (Netherlands)

    javidi, B.; Carnicer, A.; Yamaguchi, M.; Nomura, T.; Pérez-Cabré, E.; Millan, M.S.; Nishchal, N.K.; Torroba, R.; Barrera, J.F.; He, W.; Peng, X.; Stern, A.; Rivenson, Y.; Alfalou, A.; Brosseau, C.; Guo, C.; Sheridan, J.T.; Situ, G.; Naruse, M.; Matsumoto, T.; Juvells, I.; Tajahuerce, E.; Lancis, J.; Chen, Wen; Chen, X.; Markman, A.; Mosk, Allard; Pinkse, Pepijn Willemszoon Harry

    2016-01-01

    Information security and authentication are important challenges facing society. Recent attacks by hackers on the databases of large commercial and financial companies have demonstrated that more research and development of advanced approaches are necessary to deny unauthorized access to critical

  18. Technology Roadmaps: Biofuels for Transport

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    Biofuels could provide up to 27% of total transport fuel worldwide by 2050. The use of transport fuels from biomass, when produced sustainably, can help cut petroleum use and reduce CO2 emissions in the transport sector, especially in heavy transport. Sustainable biofuel technologies, in particular advanced biofuels, will play an important role in achieving this roadmap vision. The roadmap describes the steps necessary to realise this ambitious biofuels target; identifies key actions by different stakeholders, and the role for government policy to adopt measures needed to ensure the sustainable expansion of both conventional and advanced biofuel production.

  19. Building the electronic industry's roadmaps

    Science.gov (United States)

    Boulton, William R.

    1995-02-01

    JTEC panelists found a strong consistency among the electronics firms they visited: all the firms had clear visions or roadmaps for their research and development activities and had committed resources to ensure that they achieve targeted results. The overarching vision driving Japan's electronics industry is that of achieving market success through developing appealing, high-quality, low-cost consumer goods - ahead of the competition. Specifics of the vision include improving performance, quality, and portability of consumer electronics products. Such visions help Japanese companies define in detail the roadmaps they will follow to develop new and improved electronic packaging technologies.

  20. OHVT technology roadmap[2000]; TOPICAL

    International Nuclear Information System (INIS)

    Bradley, R.A.

    2000-01-01

    The OHVT Technology Roadmap for 2000 presents the multiyear program plan of the U.S. DOE's Office of Heavy Vehicle Technologies (OHVT). It is an update of the 1997 plan, reflecting changes in regulations and ongoing discussions with DOE's heavy vehicle customers. The technical plan covers three classes of trucks: (1) class 7-8 (large, on-highway trucks); (2) class 3-6 (medium duty trucks); (3) class 1-2 (pickups, vans, and sport utility vehicles) as well as enabling and supporting technologies. The Roadmap documents program goals, schedules, and milestones

  1. Biogas Opportunities Roadmap Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-12-01

    In support of the Obama Administration's Climate Action Plan, the U.S. Department of Energy, the U.S. Environmental Protection Agency, and U.S. Department of Agriculture jointly released the Biogas Opportunities Roadmap Progress Report, updating the federal government's progress to reduce methane emissions through biogas systems since the Biogas Opportunities Roadmap was completed by the three agencies in July 2014. The report highlights actions taken, outlines challenges and opportunities, and identifies next steps to the growth of a robust biogas industry.

  2. Low light illumination study on commercially available homojunction photovoltaic cells

    International Nuclear Information System (INIS)

    Russo, Johnny; Ray, William; Litz, Marc S.

    2017-01-01

    Highlights: • COTS PV cells are tested under indoor and narrow light spectra. • InGaP is the most efficient under low light conditions (0.5–100 μW opt /cm 2 ). • InGaP is selected for isotope battery. • Optimal incident wavelength (614 nm) for InGaP is identified in model. - Abstract: Low illumination (10 −4 suns) and indoor light energy harvesting is needed to meet the demands of zero net energy (ZNE) building, Internet of Things (IoT), and beta-photovoltaic energy harvesting systems to power remote sensors. Photovoltaic (PV) solar cells under low intensity and narrow (±40 nm) light spectrum conditions are not well characterized nor developed, especially for commercially available devices and scalable systems. PV operating characteristics under 1 sun illumination decrease at lower light intensity and narrow spectrum conditions (efficiency drops from ∼25% at 100 mW opt /cm 2 to 2% at 1 μW opt /cm 2 ). By choosing a PV with a bandgap that matches the light source operating wavelength, the total system efficiency can be improved. By quantifying losses on homojunction photovoltaics (thermalization and leakage current), we have determined the theoretical optimized efficiency for a set of PV material and a selected set of light sources. We measure single-junction solar cells’ parameters under three different light sources (indoor light and narrow spectrum LED sources) with light intensities ranging from 0.5 to 100 μW opt /cm 2 . Measurements show that indium gallium phosphide (InGaP) PV has the highest surface power density and conversion efficiency (29% under ≈1 μW opt /cm 2 from a 523 nm central peak LED). A beta-photovoltaic experimental study identifies InGaP to be optimized for use with the ZnS:Cu, Al and tritium at STP. The results have guided the selection of PV material for scalable isotope batteries and other low-light energy harvesting systems.

  3. Roadmap on optical sensors.

    Science.gov (United States)

    Ferreira, Mário F S; Castro-Camus, Enrique; Ottaway, David J; López-Higuera, José Miguel; Feng, Xian; Jin, Wei; Jeong, Yoonchan; Picqué, Nathalie; Tong, Limin; Reinhard, Björn M; Pellegrino, Paul M; Méndez, Alexis; Diem, Max; Vollmer, Frank; Quan, Qimin

    2017-08-01

    Sensors are devices or systems able to detect, measure and convert magnitudes from any domain to an electrical one. Using light as a probe for optical sensing is one of the most efficient approaches for this purpose. The history of optical sensing using some methods based on absorbance, emissive and florescence properties date back to the 16th century. The field of optical sensors evolved during the following centuries, but it did not achieve maturity until the demonstration of the first laser in 1960. The unique properties of laser light become particularly important in the case of laser-based sensors, whose operation is entirely based upon the direct detection of laser light itself, without relying on any additional mediating device. However, compared with freely propagating light beams, artificially engineered optical fields are in increasing demand for probing samples with very small sizes and/or weak light-matter interaction. Optical fiber sensors constitute a subarea of optical sensors in which fiber technologies are employed. Different types of specialty and photonic crystal fibers provide improved performance and novel sensing concepts. Actually, structurization with wavelength or subwavelength feature size appears as the most efficient way to enhance sensor sensitivity and its detection limit. This leads to the area of micro- and nano-engineered optical sensors. It is expected that the combination of better fabrication techniques and new physical effects may open new and fascinating opportunities in this area. This roadmap on optical sensors addresses different technologies and application areas of the field. Fourteen contributions authored by experts from both industry and academia provide insights into the current state-of-the-art and the challenges faced by researchers currently. Two sections of this paper provide an overview of laser-based and frequency comb-based sensors. Three sections address the area of optical fiber sensors, encompassing both

  4. Roadmap on optical sensors

    Science.gov (United States)

    Ferreira, Mário F. S.; Castro-Camus, Enrique; Ottaway, David J.; López-Higuera, José Miguel; Feng, Xian; Jin, Wei; Jeong, Yoonchan; Picqué, Nathalie; Tong, Limin; Reinhard, Björn M.; Pellegrino, Paul M.; Méndez, Alexis; Diem, Max; Vollmer, Frank; Quan, Qimin

    2017-08-01

    Sensors are devices or systems able to detect, measure and convert magnitudes from any domain to an electrical one. Using light as a probe for optical sensing is one of the most efficient approaches for this purpose. The history of optical sensing using some methods based on absorbance, emissive and florescence properties date back to the 16th century. The field of optical sensors evolved during the following centuries, but it did not achieve maturity until the demonstration of the first laser in 1960. The unique properties of laser light become particularly important in the case of laser-based sensors, whose operation is entirely based upon the direct detection of laser light itself, without relying on any additional mediating device. However, compared with freely propagating light beams, artificially engineered optical fields are in increasing demand for probing samples with very small sizes and/or weak light-matter interaction. Optical fiber sensors constitute a subarea of optical sensors in which fiber technologies are employed. Different types of specialty and photonic crystal fibers provide improved performance and novel sensing concepts. Actually, structurization with wavelength or subwavelength feature size appears as the most efficient way to enhance sensor sensitivity and its detection limit. This leads to the area of micro- and nano-engineered optical sensors. It is expected that the combination of better fabrication techniques and new physical effects may open new and fascinating opportunities in this area. This roadmap on optical sensors addresses different technologies and application areas of the field. Fourteen contributions authored by experts from both industry and academia provide insights into the current state-of-the-art and the challenges faced by researchers currently. Two sections of this paper provide an overview of laser-based and frequency comb-based sensors. Three sections address the area of optical fiber sensors, encompassing both

  5. Industrial wind. Strategic Road-map

    International Nuclear Information System (INIS)

    Therond, Pierre-Guy; Le Tirant, Alain; Vergnet, Marc; Hita-Perona, Sebastien; Bonnefond, Thierry; Guignard, Jean-Philippe; Roudil, Jean-Philippe; Villageois, Jean-Remy; Meyronneinc, Jean-Paul; Hua, Xavier; Herlaut, Fabienne; Maurel, Olivier; Boulnois, Renald; Lapeyre, Dominique; Mairet, Franck; Bongrain, Marie-Pierre; Kariniotakis, Georges; Rapin, Marc

    2012-06-01

    Since 2010, the ADEME has been managing four programmes within the scope of 'Future Investments'. Groups of research experts from various industrial fields, research bodies and research programming and financing agencies are responsible, within the scope of collective works, for producing strategic road-maps. These are used to launch Calls for Expressions of Interest (CEI). With regard to wind energy, the purpose of this road-map is to: - Highlight the industrial, technological, environmental and societal challenges encountered in the development of 'Industrial Wind'; - Draw up middle and long-term coherent, shared visions of the socio-technical systems or technologies in question; - Identify the technological, organisational, environmental and socio-economic obstacles, and therefore initiate (or pursue) the development of high-performance and economically viable technologies; - Promote the research, development and demonstration requirements ('technological demonstrators' to validate innovative technological solutions), experimentation requirements and technology platforms to be deployed ('pilot' projects to be tested under real circumstances: 'pre-commercial' unit prototypes then 'pre-commercial pilot farms') to improve the competitiveness of offers and companies within this sector, to reach the ambitious objectives set within the framework of the Grenelle Environnement and to promote and support the development of a French wind energy industry. These needs can then act as a basis for: - drawing up CEIs; - programming research within the ADEME and other institutions such as the Agence nationale de la recherche (ANR - French National Research Agency), the Comite strategique national sur la recherche energie (French national strategic committee for energy research) and the Alliance nationale de coordination de la recherche pour l'energie (ANCRE - French national alliance for the coordination of energy

  6. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office - 2015

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-01-08

    This FY 2015 report updates the results of an effort to identify and document the commercial and emerging (projected to be commercialized within the next 3 to 5 years) hydrogen and fuel cell technologies and products that resulted from U.S. Department of Energy support through the Fuel Cell Technologies Office in the Office of Energy Efficiency and Renewable Energy.

  7. Partnership for Wave Power - Roadmaps

    DEFF Research Database (Denmark)

    Nielsen, Kim; Krogh, Jan; Brodersen, Hans Jørgen

    This Wave Energy Technology Roadmap is developed by the Partnership for Wave Power including nine Danish wave energy developers. It builds on to the strategy [1] published by the Partnership in 2012, a document that describes the long term vision of the Danish Wave Energy sector: “By 2030...

  8. Cell Phone Carriers, TV-Commercials & Branding : A study of cell phone carriers TV- commercials, branding and its affect on young people

    OpenAIRE

    Sköld, Robin; Nilsson, Magnus

    2009-01-01

    Problem: As almost everyone has a cell phone today, keeping your customers is very important. An important group for cell phone carriers is young people. This is a group that uses cell phones more and more. However, attracting these people could be hard. One of the most common strategies to attract customers today is promotion through TV-commercials. Another strategy that has gained popularity is branding. We therefore asked ourselves how these strategies could affect each other and eventuall...

  9. Concentrating Solar Power Gen3 Demonstration Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Mehos, Mark [National Renewable Energy Lab. (NREL), Golden, CO (United States); Turchi, Craig [National Renewable Energy Lab. (NREL), Golden, CO (United States); Vidal, Judith [National Renewable Energy Lab. (NREL), Golden, CO (United States); Wagner, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ma, Zhiwen [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ho, Clifford [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kolb, William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Andraka, Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kruizenga, Alan [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2017-01-01

    Today's power-tower concentrating solar power (CSP) technology exists in large part as a result of Department of Energy (DOE) and utility industry funding of demonstration systems in the 1980s and 1990s. Today's most advanced towers are integrated with molten-salt thermal energy storage, delivering thermal energy at 565 degrees C for integration with conventional steam-Rankine cycles. The supercritical carbon dioxide power cycle has been identified as a likely successor to the steam-Rankine power cycle due to its potential for high efficiency when operating at elevated temperatures of 700 degrees C or greater. Over the course of the SunShot Initiative, DOE has supported a number of technology pathways that can operate efficiently at these temperatures and that hold promise to be reliable and cost effective. Three pathways - molten salt, particle, and gaseous - were selected for further investigation based on a two-day workshop held in August of 2016. The information contained in this roadmap identifies research and development challenges and lays out recommended research activities for each of the three pathways. DOE foresees that by successfully addressing the challenges identified in this roadmap, one or more technology pathways will be positioned for demonstration and subsequent commercialization within the next ten years. Based on current knowledge of the three power tower technologies, all three have the potential to achieve the SunShot goal of 6 cents/kilowatt-hour. Further development, modeling, and testing are now required to bring one or more of the technologies to a stage where integrated system tests and pilot demonstrations are feasible.

  10. Hanford Site Secondary Waste Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Westsik, Joseph H.

    2009-01-29

    Summary The U.S. Department of Energy (DOE) is making plans to dispose of 54 million gallons of radioactive tank wastes at the Hanford Site near Richland, Washington. The high-level wastes and low-activity wastes will be vitrified and placed in permanent disposal sites. Processing of the tank wastes will generate secondary wastes, including routine solid wastes and liquid process effluents, and these need to be processed and disposed of also. The Department of Energy Office of Waste Processing sponsored a meeting to develop a roadmap to outline the steps necessary to design the secondary waste forms. Representatives from DOE, the U.S. Environmental Protection Agency, the Washington State Department of Ecology, the Oregon Department of Energy, Nuclear Regulatory Commission, technical experts from the DOE national laboratories, academia, and private consultants convened in Richland, Washington, during the week of July 21-23, 2008, to participate in a workshop to identify the risks and uncertainties associated with the treatment and disposal of the secondary wastes and to develop a roadmap for addressing those risks and uncertainties. This report describes the results of the roadmap meeting in Richland. Processing of the tank wastes will generate secondary wastes, including routine solid wastes and liquid process effluents. The secondary waste roadmap workshop focused on the waste streams that contained the largest fractions of the 129I and 99Tc that the Integrated Disposal Facility risk assessment analyses were showing to have the largest contribution to the estimated IDF disposal impacts to groundwater. Thus, the roadmapping effort was to focus on the scrubber/off-gas treatment liquids with 99Tc to be sent to the Effluent Treatment Facility for treatment and solidification and the silver mordenite and carbon beds with the captured 129I to be packaged and sent to the IDF. At the highest level, the secondary waste roadmap includes elements addressing regulatory and

  11. Research and Development Roadmaps for Liquid Metal Cooled Fast Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Kim, T. K. [Argonne National Lab. (ANL), Argonne, IL (United States); Grandy, C. [Argonne National Lab. (ANL), Argonne, IL (United States); Natesan, K. [Argonne National Lab. (ANL), Argonne, IL (United States); Sienicki, J. [Argonne National Lab. (ANL), Argonne, IL (United States); Hill, R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-04-20

    The United States Department of Energy (DOE) commissioned the development of technology roadmaps for advanced (non-light water reactor) reactor concepts to help focus research and development funding over the next five years. The roadmaps show the research and development needed to support demonstration of an advanced (non-LWR) concept by the early 2030s, consistent with DOE’s Vision and Strategy for the Development and Deployment of Advanced Reactors. The intent is only to convey the technical steps that would be required to achieve such a goal; the means by which DOE will determine whether to invest in specific tasks will be treated separately. The starting point for the roadmaps is the Technical Readiness Assessment performed as part of an Advanced Test and Demonstration Reactor study released in 2016. The roadmaps were developed based upon a review of technical reports and vendor literature summarizing the technical maturity of each concept and the outstanding research and development needs. Critical path tasks for specific systems were highlighted on the basis of time and resources needed to complete the tasks and the importance of the system to the performance of the reactor concept. The roadmaps are generic, i.e. not specific to a particular vendor’s design but vendor design information may have been used as representative of the concept family. In the event that both near-term and more advanced versions of a concept are being developed, either a single roadmap with multiple branches or separate roadmaps for each version were developed. In each case, roadmaps point to a demonstration reactor (engineering or commercial) and show the activities that must be completed in parallel to support that demonstration in the 2030-2035 window. This report provides the roadmaps for two fast reactor concepts, the Sodium-cooled Fast Reactor (SFR) and the Lead-cooled Fast Reactor (LFR). The SFR technology is mature enough for commercial demonstration by the early 2030s

  12. Thermally activated technologies: Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2003-05-01

    The purpose of this Technology Roadmap is to outline a set of actions for government and industry to develop thermally activated technologies for converting America’s wasted heat resources into a reservoir of pollution-free energy for electric power, heating, cooling, refrigeration, and humidity control. Fuel flexibility is important. The actions also cover thermally activated technologies that use fossil fuels, biomass, and ultimately hydrogen, along with waste heat.

  13. River Protection Project Technology and Innovation Roadmap.

    Energy Technology Data Exchange (ETDEWEB)

    Reid, D. S. [Hanford Site (HNF), Richland, WA (United States); Wooley, T. A. [Hanford Site (HNF), Richland, WA (United States); Kelly, S. E. [Hanford Site (HNF), Richland, WA (United States)

    2017-08-14

    The Technology and Innovation Roadmap is a planning tool for WRPS management, DOE ORP, DOE EM, and others to understand the risks and technology gaps associated with the RPP mission. The roadmap identifies and prioritizes technical areas that require technology solutions and underscores where timely and appropriate technology development can have the greatest impact to reduce those risks and uncertainties. The roadmap also serves as a tool for determining allocation of resources.

  14. Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program - 2012

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-09-01

    This FY 2012 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  15. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office - 2014

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-02-01

    This FY 2014 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Office and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  16. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office - 2013

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-04-30

    This FY 2013 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Office and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  17. Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-09-01

    This FY 2011 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  18. High-Efficiency, Commercial Ready CdTe Solar Cells

    Energy Technology Data Exchange (ETDEWEB)

    Sites, James R. [Colorado State Univ., Fort Collins, CO (United States)

    2015-11-19

    Colorado State’s F-PACE project explored several ways to increase the efficiency of CdTe solar cells and to better understand the device physics of those cells under study. Increases in voltage, current, and fill factor resulted in efficiencies above 17%. The three project tasks and additional studies are described in detail in the final report. Most cells studied were fabricated at Colorado State using an industry-compatible single-vacuum closed-space-sublimation (CSS) chamber for deposition of the key semiconductor layers. Additionally, some cells were supplied by First Solar for comparison purposes, and a small number of modules were supplied by Abound Solar.

  19. Evaluation of Commercial-off-the-Shelf Materials for the Preservation of Gram Positive Vegetative Cells

    Science.gov (United States)

    2017-02-01

    EVALUATION OF COMMERCIAL-OFF-THE-SHELF MATERIALS FOR THE PRESERVATION OF GRAM-POSITIVE VEGETATIVE CELLS ECBC-TR-1435 Daniel Angelini...Commercial-off-the-Shelf Materials for the Preservation of Gram-Positive Vegetative Cells 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...through direct culture of the agents themselves. Materials have been developed to preserve the viability of pathogens contained within clinical

  20. Challenges in the translation and commercialization of cell therapies.

    Science.gov (United States)

    Dodson, Brittany P; Levine, Aaron D

    2015-08-07

    Cell therapies are an emerging form of healthcare that offer significant potential to improve the practice of medicine and provide benefits to patients who currently have limited or no treatment options. Ideally, these innovative therapies can complement existing small molecule, biologic and device approaches, forming a so-called fourth pillar of medicine and allowing clinicians to identify the best treatment approach for each patient. Despite this potential, cell therapies are substantially more complex than small molecule or biologic interventions. This complexity poses challenges for scientists and firms developing cell therapies and regulators seeking to oversee this growing area of medicine. In this project, we retrospectively examined the development of seven cell therapies - including three autologous interventions and four allogeneic interventions - with the aim of identifying common challenges hindering attempts to bring new cell therapies to market. We complemented this analysis with a series of qualitative interviews with experts in various aspects of cell therapy. Through our analysis, which included review of extant literature collected from company documents, newspapers, journals, analyst reports and similar sources, and analysis of the qualitative interviews, we identified several common challenges that cell therapy firms must address in both the pre- and post-market stages. Key pre-market challenges included identifying and maintaining stable funding to see firms through lengthy developmental timelines and uncertain regulatory processes. These challenges are not unique to cell therapies, of course, but the novelty of cell-based interventions complicates these efforts compared to small molecule or biologic approaches. The atypical nature of cell therapies also led to post-market difficulties, including challenges navigating the reimbursement process and convincing providers to change their treatment approaches. In addition, scaling up production

  1. Evaluation of fuel cell hybrid electric light commercial vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, G.M.

    2002-07-01

    This report summarised the results of tests both in the laboratory and in operation on the roads in London carried out to determine the performance of the Zetek Fuel Cell Vehicle operated by Westminster County Council. Details are given of the vehicle's data logging system, and measurement of its acceleration and power, driveability, vehicle range, and the energy efficiency of the fuel cell, and its environmental performance. The frequent shutdowns of the fuel cell system and the problems with the DC/DC converter are discussed.

  2. Technology Roadmaps: Energy-efficient Buildings: Heating and Cooling Equipment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    Buildings account for almost a third of final energy consumption globally and are an equally important source of CO2 emissions. Currently, both space heating and cooling as well as hot water are estimated to account for roughly half of global energy consumption in buildings. Energy-efficient and low/zero-carbon heating and cooling technologies for buildings have the potential to reduce CO2 emissions by up to 2 gigatonnes (Gt) and save 710 million tonnes oil equivalent (Mtoe) of energy by 2050. Most of these technologies -- which include solar thermal, combined heat and power (CHP), heat pumps and thermal energy storage -- are commercially available today. The Energy-Efficient Buildings: Heating and Cooling Equipment Roadmap sets out a detailed pathway for the evolution and deployment of the key underlying technologies. It finds that urgent action is required if the building stock of the future is to consume less energy and result in lower CO2 emissions. The roadmap concludes with a set of near-term actions that stakeholders will need to take to achieve the roadmap's vision.

  3. Commercialization of proton exchange membrane fuel cells for transportation applications

    Energy Technology Data Exchange (ETDEWEB)

    Wismer, L.

    1996-04-01

    Environmental concerns with air quality and global warming have triggered strict federal ambient ozone air quality standards. Areas on non-attainment of these standards exist across the United States. Because it contains several of the most difficult attainment areas, the State of California has adopted low emission standards including a zero emission vehicle mandate that has given rise to development of hybrid electric vehicles, both battery-powered and fuel-cell powered. Fuel cell powered vehicles, using on-board hydrogen as a fuel, share the non-polluting advantage of the battery electric vehicle while offering at least three times the range today`s battery technology.

  4. Technology Roadmap for the Petroleum Industry

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2000-02-01

    The petroleum refining industry defined a detailed R&D roadmap, Technology Roadmap for the Petroleum Industry, to identify high-priority areas for technology R&D. Those priorities helped ITP target cost-shared solicitations and guide development of a balanced R&D portfolio to yield useful results in the near, mid, and long-term.

  5. Industry-driven sector roadmaps 2020

    DEFF Research Database (Denmark)

    Ricard, Lykke Margot

    Industri-driven sector roadmaps 2020: European Technology Platforms in wind and CCS. A new corporate trend on innovation in Europe, supported by The European Commission.......Industri-driven sector roadmaps 2020: European Technology Platforms in wind and CCS. A new corporate trend on innovation in Europe, supported by The European Commission....

  6. The unregulated commercialization of stem cell treatments: a global perspective.

    Science.gov (United States)

    Sipp, Douglas

    2011-12-01

    Research into the biological properties and clinical potential of stem cells has spurred strong public investment, industry development, media coverage, and patient interest in recent years. To date, however, few clinical applications of demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stem cells in the treatment of diseases of the blood and immune systems. This lack of an evidence basis notwithstanding, hundreds of companies and private clinics around the world now sell putative stem cell treatments for an enormously broad range of medical and quality-of-life conditions. This represents a major challenge for legitimate scientists working in the field, for authorities seeking to protect their constituencies, and for patients and consumers targeted by such companies' marketing strategies. In this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with an investigation of claims in a single disease area (amyotrophic lateral sclerosis), and make recommendations for the introduction and enforcement of appropriate regulatory responses to this problem.

  7. Idaho National Engineering Laboratory installation roadmap document

    International Nuclear Information System (INIS)

    1993-01-01

    The roadmapping process was initiated by the US Department of Energy's office of Environmental Restoration and Waste Management (EM) to improve its Five-Year Plan and budget allocation process. Roadmap documents will provide the technical baseline for this planning process and help EM develop more effective strategies and program plans for achieving its long-term goals. This document is a composite of roadmap assumptions and issues developed for the Idaho National Engineering Laboratory (INEL) by US Department of Energy Idaho Field Office and subcontractor personnel. The installation roadmap discusses activities, issues, and installation commitments that affect waste management and environmental restoration activities at the INEL. The High-Level Waste, Land Disposal Restriction, and Environmental Restoration Roadmaps are also included

  8. Vision 2020. Reaction Engineering Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Klipstein, David H. [Reaction Design, San Diego, CA (United States); Robinson, Sharon [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2001-01-01

    The Reaction Engineering Roadmap is a part of an industry- wide effort to create a blueprint of the research and technology milestones that are necessary to achieve longterm industry goals. This report documents the results of a workshop focused on the research needs, technology barriers, and priorities of the chemical industry as they relate to reaction engineering viewed first by industrial use (basic chemicals; specialty chemicals; pharmaceuticals; and polymers) and then by technology segment (reactor system selection, design, and scale-up; chemical mechanism development and property estimation; dealing with catalysis; and new, nonstandard reactor types).

  9. An assessment of the energetic flows in a commercial PEM fuel-cell system

    International Nuclear Information System (INIS)

    Jovan, Vladimir; Perne, Matija; Petrovcic, Janko

    2010-01-01

    Some primary issues have not yet been fully investigated on the way towards the commercialization of fuel-cell-based systems (FCS), e.g., their actual efficiency, reliability, safety, degradation, maintainability, etc. This article deals with an estimation of the real energetic flows and the corresponding electrical efficiency of a commercial proton-exchange-membrane fuel-cell hydrogen-fed generator set (PEMFCS). The fuel-cell power system considered here is planned to be the source of both electrical and thermal energy in a mobile dwelling container unit with in-built fuel-cell-based cogeneration system, and for the design of a cogeneration unit the actual amount of disposable energy from the PEMFC unit should be estimated. The assessment of the actual energetic flows, the disposable energy and the consequent electrical efficiency of the case-study PEMFCS is carried out using commercial technical data for the PEMFCS.

  10. Fast and Accurate Measurement of Entropy Profiles of Commercial Lithium-Ion Cells

    International Nuclear Information System (INIS)

    Osswald, Patrick J.; Rosario, Manuel del; Garche, Jürgen; Jossen, Andreas; Hoster, Harry E.

    2015-01-01

    We report on an effective approach to speed up the measurement of thermodynamic characterization curves (entropy of reaction Δ r S(x)) of rechargeable batteries, in particular commercial 18650 lithium ion cells. We propose and demonstrate a measurement and data processing protocol that reduces the time required to record entropy profiles from time scales of weeks to time scales of hours – without loss in accuracy. For time consuming studies such as investigations on ageing of battery cells, entropy profile measurements thus become as feasible as conventional electrochemical characterisation techniques like dV/dQ or cyclic voltammetry. We demonstrate this at the examples of two ageing protocols applied to a commercial high power and a commercial high energy cell, respectively: (i) accelerated calendric aging by storing cells at 100% state of charge at 60 °C and (ii) continuous cycling with a 1C current at 25 °C

  11. Stem cell research funding policies and dynamic innovation: a survey of open access and commercialization requirements.

    Science.gov (United States)

    Lévesque, Maroussia; Kim, Jihyun Rosel; Isasi, Rosario; Knoppers, Bartha Maria; Plomer, Aurora; Joly, Yann

    2014-08-01

    This article compares and contrasts the pressures of both open access data sharing and commercialization policies in the context of publicly funded embryonic stem cell research (SCR). First, normative guidelines of international SCR organizations were examined. We then examined SCR funding guidelines and the project evaluation criteria of major funding organizations in the EU, the United Kingdom (UK), Spain, Canada and the United States. Our survey of policies revealed subtle pressures to commercialize research that include: increased funding availability for commercialization opportunities, assistance for obtaining intellectual property rights (IPRs) and legislation mandating commercialization. In lieu of open access models, funders are increasingly opting for limited sharing models or "protected commons" models that make the research available to researchers within the same region or those receiving the same funding. Meanwhile, there still is need for funding agencies to clarify and standardize terms such as "non-profit organizations" and "for-profit research," as more universities are pursuing for-profit or commercial opportunities.

  12. Innovative nuclear energy systems roadmap

    International Nuclear Information System (INIS)

    2007-12-01

    Developing nuclear energy that is sustainable, safe, has little waste by-product, and cannot be proliferated is an extremely vital and pressing issue. To resolve the four issues through free thinking and overall vision, research activities of 'innovative nuclear energy systems' and 'innovative separation and transmutation' started as a unique 21st Century COE Program for nuclear energy called the Innovative Nuclear Energy Systems for Sustainable Development of the World, COE-INES. 'Innovative nuclear energy systems' include research on CANDLE burn-up reactors, lead-cooled fast reactors and using nuclear energy in heat energy. 'Innovative separation and transmutation' include research on using chemical microchips to efficiently separate TRU waste to MA, burning or destroying waste products, or transmuting plutonium and other nuclear materials. Research on 'nuclear technology and society' and 'education' was also added in order for nuclear energy to be accepted into society. COE-INES was a five-year program ending in 2007. But some activities should be continued and this roadmap detailed them as a rough guide focusing inventions and discoveries. This technology roadmap was created for social acceptance and should be flexible to respond to changing times and conditions. (T. Tanaka)

  13. Next-generation batteries and fuel cells for commercial, military, and space applications

    CERN Document Server

    Jha, A R

    2012-01-01

    Distilling complex theoretical physical concepts into an understandable technical framework, Next-Generation Batteries and Fuel Cells for Commercial, Military, and Space Applications describes primary and secondary (rechargeable) batteries for various commercial, military, spacecraft, and satellite applications for covert communications, surveillance, and reconnaissance missions. It emphasizes the cost, reliability, longevity, and safety of the next generation of high-capacity batteries for applications where high energy density, minimum weight and size, and reliability in harsh conditions are

  14. Difference in influence of commercial industrial paints on microbial biofilms and planktonic cells

    OpenAIRE

    Grujić, Sandra M.; Radević, Stefan D.; Radojević, Ivana D.; Čomić, Ljiljana R.; Ostojić, Aleksandar M.

    2017-01-01

    This study compares the effect of commercial industrial paints on the Escherichia coli PMFKG-F2, Proteus mirabilis PMFKG-F4 and Saccharomyces cerevisiae PMFKG-F6 planktonic cells and biofilms. A MBECTM-HTP assay and standard 96 microtiter plate assay were used to test the levels of resistance of planktonic cells and biofilms. The minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC) of the tested substances, which affects planktonic cells and biofilms, were determined ...

  15. The US Molten Carbonate Fuel-Cell development and commercialization effort

    Science.gov (United States)

    Williams, Mark C.; Parsons, Edward L., Jr.; Mayfield, M. J.

    The authors discuss the status of molten carbonate fuel-cell (MCFC) development in the US, including the role of the US Department of Energy (DOE) in commercializing MCFC power-plant products for use by gas utility and electric power industries. The authors describe major fundamental stack research issues, as well as MCFC power-plant network and system issues, that need to be resolved before MCFC technology can be commercialized. A significant initiative in MCFC research is the spatial configuration of MCFC stacks into networks in a fuel-cell power plant.

  16. TECHNOLOGY ROADMAPPING FOR IAEA SEALS.

    Energy Technology Data Exchange (ETDEWEB)

    HOFFHEINS,B.; ANNESE,C.; GOODMAN,M.; OCONNOR,W.; GUSHUE,S.; PEPPER,S.

    2003-07-13

    In the fall of 2002, the U.S. Support Program (USSP) initiated an effort to define a strategy or ''roadmap'' for future seals technologies and to develop a generalized process for planning safeguards equipment development, which includes seals and other safeguards equipment. The underlying objectives of the USSP include becoming more proactive than reactive in addressing safeguards equipment needs, helping the IAEA to maintain an inventory of cost-effective, reliable, and effective safeguards equipment, establishing a long-term planning horizon, and securing IAEA ownership in the process of effective requirements definition and timely transitioning of new or improved systems for IAEA use. At an initial workshop, seals, their functions, performance issues, and future embodiments were discussed in the following order: adhesive seals, metal seals, passive and active loop seals, ultrasonic seals, tamper indicating enclosures (including sample containers, equipment enclosures, and conduits). Suggested improvements to these technologies focused largely on a few themes: (1) The seals must be applied quickly, easily, and correctly; (2) Seals and their associated equipment should not unduly add bulk or weight to the inspectors load; (3) Rapid, in-situ verifiability of seals is desirable; and (4) Seal systems for high risk or high value applications should have two-way, remote communications. Based upon these observations and other insights, the participants constructed a skeletal approach for seals technology planning. The process begins with a top-level review of the fundamental safeguards requirements and extraction of required system features, which is followed by analysis of suitable technologies and identification of technology gaps, and finally by development of a planning schedule for system improvements and new technology integration. Development of a comprehensive procedure will require the partnership and participation of the IAEA. The

  17. TECHNOLOGY ROADMAPPING FOR IAEA SEALS

    International Nuclear Information System (INIS)

    HOFFHEINS, B.; ANNESE, C.; GOODMAN, M.; OCONNOR, W.; GUSHUE, S.; PEPPER, S.

    2003-01-01

    In the fall of 2002, the U.S. Support Program (USSP) initiated an effort to define a strategy or ''roadmap'' for future seals technologies and to develop a generalized process for planning safeguards equipment development, which includes seals and other safeguards equipment. The underlying objectives of the USSP include becoming more proactive than reactive in addressing safeguards equipment needs, helping the IAEA to maintain an inventory of cost-effective, reliable, and effective safeguards equipment, establishing a long-term planning horizon, and securing IAEA ownership in the process of effective requirements definition and timely transitioning of new or improved systems for IAEA use. At an initial workshop, seals, their functions, performance issues, and future embodiments were discussed in the following order: adhesive seals, metal seals, passive and active loop seals, ultrasonic seals, tamper indicating enclosures (including sample containers, equipment enclosures, and conduits). Suggested improvements to these technologies focused largely on a few themes: (1) The seals must be applied quickly, easily, and correctly; (2) Seals and their associated equipment should not unduly add bulk or weight to the inspectors' load; (3) Rapid, in-situ verifiability of seals is desirable; and (4) Seal systems for high risk or high value applications should have two-way, remote communications. Based upon these observations and other insights, the participants constructed a skeletal approach for seals technology planning. The process begins with a top-level review of the fundamental safeguards requirements and extraction of required system features, which is followed by analysis of suitable technologies and identification of technology gaps, and finally by development of a planning schedule for system improvements and new technology integration. Development of a comprehensive procedure will require the partnership and participation of the IAEA. The presentation will include a

  18. Li plating as unwanted side reaction in commercial Li-ion cells - A review

    Science.gov (United States)

    Waldmann, Thomas; Hogg, Björn-Ingo; Wohlfahrt-Mehrens, Margret

    2018-04-01

    Deposition of Lithium metal on anodes contributes significantly to ageing of Li-ion cells. Lithium deposition is connected not only to a drastic limitation of life-time, but also to fast-charging capability and safety issues. Lithium deposition in commercial Li-ion cells is not limited to operation conditions at low temperatures. In recent publications various types of commercial cells were investigated using complimentary analysis methods. Five cell types studied in literature (18650, 26650, pouch) serve as a basis for comparison when and why Li deposition happens in commercial Li-ion cells. In the present paper, we reviewed literature on (i) causes, (ii) hints and evidences for Li deposition, (iii) macroscopic morphology of Li deposition/plating, (iv) ageing mechanisms and shapes of capacity fade curves involving Li deposition, and (v) influences of Li deposition on safety. Although often discussed, safety issues regarding Li deposition are not only limited to dendrite growth and internal short circuits, but also to exothermic reactions in the presence of Lithium metal. Furthermore, we tried to connect knowledge from different length scales including the macroscopic level (Li-ion cells, operating conditions, gradients in cells, electrochemical tests, safety tests), the microscopic level (electrodes, particles, microstructure), and the atomic level (atoms, ions, molecules, energy barriers).

  19. L929 cell cytotoxicity associated with experimental and commercial dental flosses

    Science.gov (United States)

    Tua-ngam, P.; Supanitayanon, L.; Dechkunakorn, S.; Anuwongnukroh, N.; Srikhirin, T.; Roongrujimek, P.

    2017-11-01

    This aim of the study was to investigate the cytotoxicity of two commercial and two experimental dental flosses. Two commercial, Oral B® Essential Floss (nylon-waxed) and Thai Silk Floss (silk-waxed), and two experimental, Floss X (nylon-waxed) and Floss Xu (nylon-unwaxed) dental flosses were used. The cytotoxic assay was performed by using cell cultures (L929) which were subjected to cell viability test with methyl-tetrazolium. Each floss specimen (0.4 g) was placed in 1 ml of Minimum Essential Medium at 37°C with 5% CO2 at 100% humidity in an incubator for 24 hours. After incubation, the cell mitochondrial activity was evaluated for detecting viable cells using optical density as per the guidelines of ISO 10993-5:2009(E). Cytotoxic effects were evaluated by measuring percentage of cell viability at 3 points of time- 5 mins, 30 mins, and 1 hr. The results showed that two commercial dental flosses and Floss X had cell viability about 90% at the three time points; however, the experimental Floss Xu presented 80% cell viability at 5 min and dental flosses and the experimental dental floss with wax tested in this study were acceptable for clinical use.

  20. Roadmap-Based Level Clearing of Buildings

    KAUST Repository

    Rodriguez, Samuel

    2011-01-01

    In this paper we describe a roadmap-based approach for a multi-agent search strategy to clear a building or multi-story environment. This approach utilizes an encoding of the environment in the form of a graph (roadmap) that is used to encode feasible paths through the environment. The roadmap is partitioned into regions, e.g., one per level, and we design region-based search strategies to cover and clear the environment. We can provide certain guarantees within this roadmap-based framework on coverage and the number of agents needed. Our approach can handle complex and realistic environments where many approaches are restricted to simple 2D environments. © 2011 Springer-Verlag.

  1. VistA 4 Product Roadmap

    Data.gov (United States)

    Department of Veterans Affairs — The VistA 4 Product Roadmap outlines how the Department of Veterans Affairs (VA), under the direction of the VistA Evolution Program, will build upon the previous...

  2. Overview of commercialization of stationary fuel cell power plants in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Hooie, D.T.; Williams, M.C.

    1995-07-01

    In this paper, DOE`s efforts to assist private sector organizations to develop and commercialize stationary fuel cell power plants in the United States are discussed. The paper also provides a snapshot of the status of stationary power fuel cell development occurring in the US, addressing all fuel cell types. This paper discusses general characteristics, system configurations, and status of test units and demonstration projects. The US DOE, Morgantown Energy Technology Center is the lead center for implementing DOE`s program for fuel cells for stationary power.

  3. A roadmap to the realization of fusion energy

    International Nuclear Information System (INIS)

    Romanelli, Francesco

    2013-01-01

    With the reduction of CO2 emissions driving future energy policy, fusion can start market penetration beyond 2050 with up to 30% of electricity production by 2100. This requires an ambitious, yet realistic roadmap towards the demonstration of electricity production by 2050. This talk describes the main technical challenges on the path to fusion energy. For all of the challenges candidate solutions have been developed and the goal of the programme is now to demonstrate that they will also work at the scale of reactor. The roadmap has been developed within a goal-oriented approach articulated in eight different Missions. For each Mission the critical aspects for reactor application, the risks and risk mitigation strategies, the level of readiness now and after ITER and the gaps in the programme have been examined with involvement of experts from the ITER International Organization, Fusion for Energy, EFDA Close Support Unites and EFDA Associates. High-level work packages for the roadmap implementation have been prepared and the resources evaluated. ITER is the key facility in the roadmap and its success represents the most important overarching objectives of the EU programme. A demonstration fusion power plant (DEMO), producing net electricity for the grid at the level of a few hundreds MW is foreseen to start operation in the early 2040s. Following ITER, it will be the single step to a commercial fusion power plant. Industry must be involved early in the DEMO definition and design. The evolution of the programme requires that industry progressively shifts its role from that of provider of high-tech components to that of driver of the fusion development. Industry must be able to take full responsibility for the commercial fusion power plant after successful DEMO operation. For this reason, DEMO cannot be defined and designed by research laboratories alone, but requires the full involvement of industry in all technological and systems aspects of the design. Europe

  4. Commercialization basics for the photonics industry

    CERN Document Server

    Krohn, David A

    2013-01-01

    Most entrepreneurs have expertise in one or more of the critical areas of commercialization, but may lack key elements necessary for success. Commercialization Basics for the Photonics Industry serves as a roadmap for the commercialization process, helping identify and address roadblocks on the path to commercialization. Evaluation techniques will help determine the strength of a business opportunity and guide its development toward the best chance of success.

  5. Cross-functional shifts in roadmapping : Sequence analysis of roadmapping practices at a large corporation

    NARCIS (Netherlands)

    Simonse, W.L.; Perks, H.

    2014-01-01

    This study unravels the nature of inter-functional integration in roadmapping. Roadmapping is indicated as an important innovation phenomenon and is practiced by multiple large organizations. Functional integration is widely acknowledged to play a significant role in enhancing new product success.

  6. Fuel cells are a commercially viable alternative for the production of "clean" energy.

    Science.gov (United States)

    Niakolas, Dimitris K; Daletou, Maria; Neophytides, Stylianos G; Vayenas, Constantinos G

    2016-01-01

    Fuel cells present a highly efficient and environmentally friendly alternative technology for decentralized energy production. The scope of the present study is to provide an overview of the technological and commercialization readiness level of fuel cells. Specifically, there is a brief description of their general advantages and weaknesses in correlation with various technological actions and political strategies, which are adopted towards their proper positioning in the global market. Some of the most important key performance indicators are also discussed, alongside with a few examples of broad commercialization. It is concluded that the increasing number of companies which utilize and invest on this technology, in combination with the supply chain improvements and the concomitant technological maturity and recognition, reinforce the fuel cell industry so as to become well-aligned for global success.

  7. Proton exchange membrane fuel cells for electrical power generation on-board commercial airplanes

    International Nuclear Information System (INIS)

    Pratt, Joseph W.; Klebanoff, Leonard E.; Munoz-Ramos, Karina; Akhil, Abbas A.; Curgus, Dita B.; Schenkman, Benjamin L.

    2013-01-01

    Highlights: ► We examine proton exchange membrane fuel cells on-board commercial airplanes. ► We model the added fuel cell system’s effect on overall airplane performance. ► It is feasible to implement an on-board fuel cell system with current technology. ► Systems that maximize waste heat recovery are the best performing. ► Current PEM and H 2 storage technology results in an airplane performance penalty. -- Abstract: Deployed on a commercial airplane, proton exchange membrane (PEM) fuel cells may offer emissions reductions, thermal efficiency gains, and enable locating the power near the point of use. This work seeks to understand whether on-board fuel cell systems are technically feasible, and, if so, if they could offer a performance advantage for the airplane when using today’s off-the-shelf technology. We also examine the effects of the fuel cell system on airplane performance with (1) different electrical loads, (2) different locations on the airplane, and (3) expected advances in fuel cell and hydrogen storage technologies. Through hardware analysis and thermodynamic simulation, we found that an additional fuel cell system on a commercial airplane is technically feasible using current technology. Although applied to a Boeing 787-type airplane, the method presented is applicable to other airframes as well. Recovery and on-board use of the heat and water that is generated by the fuel cell is an important method to increase the benefit of such a system. The best performance is achieved when the fuel cell is coupled to a load that utilizes the full output of the fuel cell for the entire flight. The effects of location are small and location may be better determined by other considerations such as safety and modularity. Although the PEM fuel cell generates power more efficiently than the gas turbine generators currently used, when considering the effect of the fuel cell system on the airplane’s overall performance we found that an overall

  8. Extensive EIS characterization of commercially available lithium polymer battery cell for performance modelling

    DEFF Research Database (Denmark)

    Stanciu, Tiberiu; Stroe, Daniel Loan; Teodorescu, Remus

    2015-01-01

    Electrochemical Impedance Spectroscopy (EIS) has become a popular analytical technique for research and development of battery cells' chemistries, due to the established, high precision computer controlled equipment, that are capable of direct, on-line monitoring of performance parameters...... on the performance of a commercially available 53 Ah Lithium polymer battery cell, manufactured by Kokam Co. Ltd., is investigated in laboratory experiments, at its beginning of life, by means of EIS. A data fitting algorithm was used to obtain the parameter values for the proposed equivalent electrical circuit......, which was further selected for the development of an accurate EIS based performance model for the chosen Li-ion battery cell....

  9. Proton exchange membrane fuel cells for electrical power generation on-board commercial airplanes.

    Energy Technology Data Exchange (ETDEWEB)

    Curgus, Dita Brigitte; Munoz-Ramos, Karina (Sandia National Laboratories, Albuquerque, NM); Pratt, Joseph William; Akhil, Abbas Ali (Sandia National Laboratories, Albuquerque, NM); Klebanoff, Leonard E.; Schenkman, Benjamin L. (Sandia National Laboratories, Albuquerque, NM)

    2011-05-01

    Deployed on a commercial airplane, proton exchange membrane fuel cells may offer emissions reductions, thermal efficiency gains, and enable locating the power near the point of use. This work seeks to understand whether on-board fuel cell systems are technically feasible, and, if so, if they offer a performance advantage for the airplane as a whole. Through hardware analysis and thermodynamic and electrical simulation, we found that while adding a fuel cell system using today's technology for the PEM fuel cell and hydrogen storage is technically feasible, it will not likely give the airplane a performance benefit. However, when we re-did the analysis using DOE-target technology for the PEM fuel cell and hydrogen storage, we found that the fuel cell system would provide a performance benefit to the airplane (i.e., it can save the airplane some fuel), depending on the way it is configured.

  10. Proton Exchange Membrane Fuel Cells for Electrical Power Generation On-Board Commercial Airplanes

    Energy Technology Data Exchange (ETDEWEB)

    Pratt, Joesph W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Klebanoff, Leonard E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Munoz-Ramos, Karina [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Akhil, Abbas A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Curgus, Dita B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Schenkman, Benjamin L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2011-05-01

    Deployed on a commercial airplane, proton exchange membrane fuel cells may offer emissions reductions, thermal efficiency gains, and enable locating the power near the point of use. This work seeks to understand whether on-board fuel cell systems are technically feasible, and, if so, if they offer a performance advantage for the airplane as a whole. Through hardware analysis and thermodynamic and electrical simulation, we found that while adding a fuel cell system using today’s technology for the PEM fuel cell and hydrogen storage is technically feasible, it will not likely give the airplane a performance benefit. However, when we re-did the analysis using DOE-target technology for the PEM fuel cell and hydrogen storage, we found that the fuel cell system would provide a performance benefit to the airplane (i.e., it can save the airplane some fuel), depending on the way it is configured.

  11. Heat Roadmap Europe 3 (STRATEGO)

    DEFF Research Database (Denmark)

    Connolly, David; Hansen, Kenneth; Drysdale, David

    Heat Roadmap Europe 3 is from work package 2 of the STRATEGO project (http://stratego-project.eu/). It quantifies the impact of implementing various energy efficiency measures in the heating and cooling sectors of five EU Member States: Czech Republic, Croatia, Italy, Romania, and the United King...... States to simultaneously reduce energy demand, imported fossil fuels, carbon dioxide emissions, and the cost of the heating, cooling, and electricity sectors......., and electricity sectors is reduced by an average of ~15% in each country. These initial investments are primarily required in heat savings for the buildings, district heating in urban areas, and electric heat pumps in rural areas. In essence, energy efficiency measures in the heating sector will enable EU Member...... of approximately €1.1 trillion in energy efficiency measures across all five of these countries, between 2010 and 2050, will save enough fuel to reduce the costs of their energy systems. After considering both the initial investment and the resulting savings, the total annual cost of the heating, cooling...

  12. Technology Roadmaps: Concentrating Solar Power

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    The emerging technology known as concentrating solar power, or CSP, holds much promise for countries with plenty of sunshine and clear skies. Its electrical output matches well the shifting daily demand for electricity in places where airconditioning systems are spreading. When backed up by thermal storage facilities and combustible fuel, it offers utilities electricity that can be dispatched when required, enabling it to be used for base, shoulder and peak loads. Within about one to two decades, it will be able to compete with coal plants that emit high levels of CO2. The sunniest regions, such as North Africa, may be able to export surplus solar electricity to neighbouring regions, such as Europe, where demand for electricity from renewable sources is strong. In the medium-to-longer term, concentrating solar facilities can also produce hydrogen, which can be blended with natural gas, and provide low-carbon liquid fuels for transport and other end-use sectors. For CSP to claim its share of the coming energy revolution, concerted action is required over the next ten years by scientists, industry, governments, financing institutions and the public. This roadmap is intended to help drive these indispensable developments.

  13. Pathways to Commercial Success: Technologies and Innovations Enabled by the U.S. Department of Energy Fuel Cell Technologies Office

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2017-10-11

    This report published in October 2017 updates the results of an effort to identify and document the commercial and emerging (projected to be commercialized within the next 3 to 5 years) hydrogen and fuel cell technologies and products that resulted from U.S. Department of Energy support through the Fuel Cell Technologies Office in the Office of Energy Efficiency and Renewable Energy.

  14. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    Weakley, Steven A.

    2012-09-28

    The purpose of the project described in this report is to identify and document the commercial and emerging (projected to be commercialized within the next 3 years) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies (FCT) Program in the Office of Energy Efficiency and Renewable Energy (EERE). Pacific Northwest National Laboratory (PNNL) undertook two efforts simultaneously to accomplish this project. The first effort was a patent search and analysis to identify patents related to hydrogen and fuel cells that are associated with FCT-funded projects (or projects conducted by DOE-EERE predecessor programs) and to ascertain the patents’ current status, as well as any commercial products that may have used the technology documented in the patent. The second effort was a series of interviews with current and past FCT personnel, a review of relevant program annual reports, and an examination of grants made under the Small Business Innovation Research and Small Business Technology Transfer Programs that are related to hydrogen and fuel cells.

  15. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    Weakley, Steven A.; Brown, Scott A.

    2011-09-29

    The purpose of the project described in this report is to identify and document the commercial and emerging (projected to be commercialized within the next 3 years) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies (FCT) Program in the Office of Energy Efficiency and Renewable Energy (EERE). To do this, Pacific Northwest National Laboratory (PNNL) undertook two efforts simultaneously to accomplish this project. The first effort was a patent search and analysis to identify hydrogen- and fuel-cell-related patents that are associated with FCT-funded projects (or projects conducted by DOE-EERE predecessor programs) and to ascertain the patents current status, as well as any commercial products that may have used the technology documented in the patent. The second effort was a series of interviews with current and past FCT personnel, a review of relevant program annual reports, and an examination of hydrogen- and fuel-cell-related grants made under the Small Business Innovation Research and Small Business Technology Transfer Programs, and within the FCT portfolio.

  16. Stimulation of endothelial cells by protease activity in commercial preparations of xanthine oxidase.

    Science.gov (United States)

    Ager, A; Wenham, D J; Gordon, J L

    1984-07-01

    The oxygen radical generating system of xanthine oxidase plus xanthine, which has been used as a model for the oxidative burst of activated granulocytes, is known to damage endothelium in vivo and in vitro. We previously observed effects (inhibited by catalase, and thus associated with the formation of H2O2) on several parameters of endothelial function, using a non-commercial preparation of xanthine oxidase. Our present study demonstrates that xanthine oxidase from two different commercial sources has additional effects on endothelial morphology and ion flux that are substrate-independent (i.e. produced in the absence of added xanthine) and are attributable to the presence of pancreatin (a crude enzyme mixture used in the commercial preparation of xanthine oxidase from milk). These effects are related to the tryptic activity of pancreatin and extend previous observations on the effects of neutral proteases on endothelial cells. Our results emphasise the practical point that studies on the effects of commercial xanthine oxidase preparations on endothelial cells must take account of their trypsin-like activity as well as their capacity to generate oxygen products.

  17. Energy analysis of fuel cell system for commercial greenhouse application – A feasibility study

    International Nuclear Information System (INIS)

    Vadiee, Amir; Yaghoubi, Mahmoud; Sardella, Marco; Farjam, Pardis

    2015-01-01

    Highlights: • Feasibility study of integrating a PEMFC with a commercial greenhouse. • An energy analysis has been performed in order to evaluate the energetic performance of the system. • A sensitivity analysis on the main influencing operating parameters for optimization. - Abstract: The purpose of this paper is to investigate the feasibility of integrating a proton exchange membrane fuel cell (PEMFC) system with a commercial greenhouse and assess the mutual benefits of such integration. The main objective is to recover the low quality waste heat of the PEMFC system in order to meet the thermal energy demand of a commercial greenhouse. In addition the PEMFC covers the some part of the greenhouse electrical demand. In this study an energy analysis has been performed in order to evaluate the energetic performance of the system. To achieve these aims, first, a system model has been developed using TRNSYS. Afterwards, a sensitivity analysis has been carried out varying the main influencing operating parameters in order to evaluate an optimal configuration of the system. In particular the influences of temperature and air stoichiometry have been investigated. The results show that a 3 kW fuel cell system is capable to cover approximately the 25% and 10% of the usual electricity and heat demands of a 1000 m 2 commercial greenhouse during a year, respectively

  18. From clinical proof-of-concept to commercialization of CAR T cells.

    Science.gov (United States)

    Calmels, Boris; Mfarrej, Bechara; Chabannon, Christian

    2018-01-06

    The development of CAR T cells currently represents an exciting opportunity to convert the already published clinical successes observed in clinical trials into commercially available efficient therapies. However, the path toward successful commercialization is still hindered by many hurdles. Here, we review such issues as: the need for structured collaborations between hospital collection and clinical facilities and industry manufacturing facilities to streamline the supply chain; necessity for uniform and efficient medical procedures to cope with severe toxicities associated with CAR T cells; and absolute need to define an economical and sustainable model for manufacturers and payers. The fast pace at which the field is evolving requires careful assessments for the benefit of patients. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. NASA Technology Area 07: Human Exploration Destination Systems Roadmap

    Science.gov (United States)

    Kennedy, Kriss J.; Alexander, Leslie; Landis, Rob; Linne, Diane; Mclemore, Carole; Santiago-Maldonado, Edgardo; Brown, David L.

    2011-01-01

    This paper gives an overview of the National Aeronautics and Space Administration (NASA) Office of Chief Technologist (OCT) led Space Technology Roadmap definition efforts. This paper will given an executive summary of the technology area 07 (TA07) Human Exploration Destination Systems (HEDS). These are draft roadmaps being reviewed and updated by the National Research Council. Deep-space human exploration missions will require many game changing technologies to enable safe missions, become more independent, and enable intelligent autonomous operations and take advantage of the local resources to become self-sufficient thereby meeting the goal of sustained human presence in space. Taking advantage of in-situ resources enhances and enables revolutionary robotic and human missions beyond the traditional mission architectures and launch vehicle capabilities. Mobility systems will include in-space flying, surface roving, and Extra-vehicular Activity/Extravehicular Robotics (EVA/EVR) mobility. These push missions will take advantage of sustainability and supportability technologies that will allow mission independence to conduct human mission operations either on or near the Earth, in deep space, in the vicinity of Mars, or on the Martian surface while opening up commercialization opportunities in low Earth orbit (LEO) for research, industrial development, academia, and entertainment space industries. The Human Exploration Destination Systems (HEDS) Technology Area (TA) 7 Team has been chartered by the Office of the Chief Technologist (OCT) to strategically roadmap technology investments that will enable sustained human exploration and support NASA s missions and goals for at least the next 25 years. HEDS technologies will enable a sustained human presence for exploring destinations such as remote sites on Earth and beyond including, but not limited to, LaGrange points, low Earth orbit (LEO), high Earth orbit (HEO), geosynchronous orbit (GEO), the Moon, near

  20. Monoplane 3D Overlay Roadmap versus Conventional Biplane 2D Roadmap Technique for Neurointervenional Procedures.

    Science.gov (United States)

    Jang, Dong-Kyu; Stidd, David A; Schafer, Sebastian; Chen, Michael; Moftakhar, Roham; Lopes, Demetrius K

    2016-09-01

    We investigated whether a 3D overlay roadmap using monoplane fluoroscopy offers advantages over a conventional 2D roadmap using biplane fluoroscopy during endovascular aneurysm treatment. A retrospective chart review was conducted for 131 consecutive cerebral aneurysm embolizations by three neurointerventionalists at a single institution. Allowing for a transition period, the periods from January 2012 to August 2012 (Time Period 1) and February 2013 to July 2013 (Time Period 2) were analyzed for radiation exposure, contrast administration, fluoroscopy time, procedure time, angiographic results, and perioperative complications. Two neurointerventionalists (Group 1) used a conventional 2D roadmap for both Time Periods, and one neurointerventionalist (Group 2) transitioned from a 2D roadmap during Time Period 1 to a 3D overlay roadmap during Time Period 2. During Time Period 2, Group 2 demonstrated reduced fluoroscopy time (poverlay roadmap technique reduced fluoroscopy dose and fluoroscopy time during neurointervention of cerebral aneurysms with similar angiographic occlusions and complications rate relative to biplane 2D roadmap, which implies possible compensation of limitations of monoplane fluoroscopy by 3D overlay technique.

  1. Technology Roadmaps: Bioenergy for Heat and Power

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-08-01

    The Technology Roadmap Bioenergy for Heat and Power highlights the importance of bioenergy in providing heat in the buildings sector and in industry, and shows what contribution it could make to meeting steadlily growing world electricity demand. The critical role of sustainability as well as the importance of international trade in meeting the projected demand for bioenergy, are highlighted in the roadmap, as well as the need for large-scale biomass plants in providing The roadmap identifies key actions by different stakeholders in the bioenergy sector, and sets out milestones for technology development in order to achieve a doubling of global bioenergy supply by 2050. It addresses the need for further R&D efforts, highlights measures to ensure sustainability of biomass production, and underlines the need for international collaboration to enhance the production and use of sustainable, modern bioenergy in different world regions.

  2. Technology Roadmaps: Bioenergy for Heat and Power

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    The Technology Roadmap Bioenergy for Heat and Power highlights the importance of bioenergy in providing heat in the buildings sector and in industry, and shows what contribution it could make to meeting steadlily growing world electricity demand. The critical role of sustainability as well as the importance of international trade in meeting the projected demand for bioenergy, are highlighted in the roadmap, as well as the need for large-scale biomass plants in providing The roadmap identifies key actions by different stakeholders in the bioenergy sector, and sets out milestones for technology development in order to achieve a doubling of global bioenergy supply by 2050. It addresses the need for further R&D efforts, highlights measures to ensure sustainability of biomass production, and underlines the need for international collaboration to enhance the production and use of sustainable, modern bioenergy in different world regions.

  3. Technology Roadmap: Lab-on-a-Chip

    Directory of Open Access Journals (Sweden)

    Pattharaporn Suntharasaj

    2010-04-01

    Full Text Available With the integration of microfluidic and MEMS technologies, biochips such as the lab-on-a-chip (LOC devices are at the brink of revolutionizing the medical disease diagnostics industries. Remarkable advancements in the biochips industry are making products resembling Star Trek.s "tricorder" and handheld medical scanners a reality. Soon, doctors can screen for cancer at the molecular level without costly and cumbersome equipments, and discuss treatment plans based on immediate lab results. This paper develops a roadmap for a hypothetical company (XI which is seeking to be successful in this market. The roadmapping process starts with gathering data through literature research and expert opinions, and progress through defining the market/product/technology layers, linking and integrating these layers, and finally creating a labon-a-chip for disease diagnostics technology roadmap.

  4. Proposed roadmap for overcoming legal and financial obstacles to carbon capture and sequestration

    Energy Technology Data Exchange (ETDEWEB)

    Jacobs, Wendy (Harvard Environmental Law and Policy, Cambridge, MA (US)); Chohen, Leah; Kostakidis-Lianos, Leah; Rundell, Sara (Harvard Law School, Cambridge, MA (US))

    2009-03-01

    Many existing proposals either lack sufficient concreteness to make carbon capture and geological sequestration (CCGS) operational or fail to focus on a comprehensive, long term framework for its regulation, thus failing to account adequately for the urgency of the issue, the need to develop immediate experience with large scale demonstration projects, or the financial and other incentives required to launch early demonstration projects. We aim to help fill this void by proposing a roadmap to commercial deployment of CCGS in the United States.This roadmap focuses on the legal and financial incentives necessary for rapid demonstration of geological sequestration in the absence of national restrictions on CO2 emissions. It weaves together existing federal programs and financing opportunities into a set of recommendations for achieving commercial viability of geological sequestration.

  5. Hydrogen Storage Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The mission of the Hydrogen Storage Technical Team is to accelerate research and innovation that will lead to commercially viable hydrogen-storage technologies that meet the U.S. DRIVE Partnership goals.

  6. Human Exploration Systems and Mobility Capability Roadmap Progress Review

    Science.gov (United States)

    Culbert, Chris; Taylor, Jeff

    2005-01-01

    Contents include the following: Capability Roadmap Team. Capability Description and Capability Breakdown Structure. Benefits of the Human Systems and Mobility Capability. Roadmap Process and Approach. Drivers and Assumptions for the whole team. Current State-of-the-Art, Assumptions and Requirements will be covered in the appropriate sections. Capability Presentations by Leads under Roadmap (Repeated for each capability under roadmap). Capability Description, Benefits, Current State-of-the-Art. Capability Requirements and Assumptions. Roadmap for Capability. Capability Readiness Level. Technology Readiness Level. Figures of Merit. Summary of Top Level Capability. Significant Technical Challenges. Summary and Forward Work.

  7. The 2015 super-resolution microscopy roadmap

    International Nuclear Information System (INIS)

    Hell, Stefan W; Sahl, Steffen J; Bates, Mark; Jakobs, Stefan; Zhuang, Xiaowei; Heintzmann, Rainer; Booth, Martin J; Bewersdorf, Joerg; Shtengel, Gleb; Hess, Harald; Tinnefeld, Philip; Honigmann, Alf; Testa, Ilaria; Cognet, Laurent; Lounis, Brahim; Ewers, Helge; Davis, Simon J; Eggeling, Christian; Klenerman, David; Willig, Katrin I

    2015-01-01

    Far-field optical microscopy using focused light is an important tool in a number of scientific disciplines including chemical, (bio)physical and biomedical research, particularly with respect to the study of living cells and organisms. Unfortunately, the applicability of the optical microscope is limited, since the diffraction of light imposes limitations on the spatial resolution of the image. Consequently the details of, for example, cellular protein distributions, can be visualized only to a certain extent. Fortunately, recent years have witnessed the development of ‘super-resolution’ far-field optical microscopy (nanoscopy) techniques such as stimulated emission depletion (STED), ground state depletion (GSD), reversible saturated optical (fluorescence) transitions (RESOLFT), photoactivation localization microscopy (PALM), stochastic optical reconstruction microscopy (STORM), structured illumination microscopy (SIM) or saturated structured illumination microscopy (SSIM), all in one way or another addressing the problem of the limited spatial resolution of far-field optical microscopy. While SIM achieves a two-fold improvement in spatial resolution compared to conventional optical microscopy, STED, RESOLFT, PALM/STORM, or SSIM have all gone beyond, pushing the limits of optical image resolution to the nanometer scale. Consequently, all super-resolution techniques open new avenues of biomedical research. Because the field is so young, the potential capabilities of different super-resolution microscopy approaches have yet to be fully explored, and uncertainties remain when considering the best choice of methodology. Thus, even for experts, the road to the future is sometimes shrouded in mist. The super-resolution optical microscopy roadmap of Journal of Physics D: Applied Physics addresses this need for clarity. It provides guidance to the outstanding questions through a collection of short review articles from experts in the field, giving a thorough

  8. Lifetime limiting effects in pre-commercial solid oxide cell devices

    DEFF Research Database (Denmark)

    Skafte, Theis Løye

    of degradationand lifetime was conducted. It is shown that the technology is approaching the officialtargets required for commercialization, but that work remains to be done.  It is further recognized that targeting nicheapplications initially will allow for employment of economies of scale, whichwill bring down......The solidoxide electrochemical cell technology is promising for efficient energy storage,especially when the share of intermittent renewable electricity production ishigh. The technology is being commercialized in niche markets, but large-scale employmentis still hindered by limited durability...... of the devices. The lifetime limitingmechanisms are addressed in this work. A generalintroduction into mechanisms limiting the durability is presented. A databaseof more than 50 parameters from 150 publications and 1 000 000 hours ofaccumulated testing was established, and a quantitative analysis...

  9. Experimental study of commercial size proton exchange membrane fuel cell performance

    International Nuclear Information System (INIS)

    Yan, Wei-Mon; Wang, Xiao-Dong; Lee, Duu-Jong; Zhang, Xin-Xin; Guo, Yi-Fan; Su, Ay

    2011-01-01

    Commercial sized (16 x 16 cm 2 active surface area) proton exchange membrane (PEM) fuel cells with serpentine flow chambers are fabricated. The GORE-TEX (registered) PRIMEA 5621 was used with a 35-μm-thick PEM with an anode catalyst layer with 0.45 mg cm -2 Pt and cathode catalyst layer with 0.6 mg cm -2 Pt and Ru or GORE-TEX (registered) PRIMEA 57 was used with an 18-μm-thick PEM with an anode catalyst layer at 0.2 mg cm -2 Pt and cathode catalyst layer at 0.4 mg cm -2 of Pt and Ru. At the specified cell and humidification temperatures, the thin PRIMEA 57 membrane yields better cell performance than the thick PRIMEA 5621 membrane, since hydration of the former is more easily maintained with the limited amount of produced water. Sufficient humidification at both the cathode and anode sides is essential to achieve high cell performance with a thick membrane, like the PRIMEA 5621. The optimal cell temperature to produce the best cell performance with PRIMEA 5621 is close to the humidification temperature. For PRIMEA 57, however, optimal cell temperature exceeds the humidification temperature.

  10. Experimental study of commercial size proton exchange membrane fuel cell performance

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Wei-Mon; Guo, Yi-Fan [Department of Greenergy, National University of Tainan, Tainan 700 (China); Wang, Xiao-Dong; Zhang, Xin-Xin [Department of Thermal Engineering, School of Mechanical Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Lee, Duu-Jong [Department of Chemical Engineering, College of Engineering, National Taiwan University of Science and Technology, Taipei 106 (China); Su, Ay [Department of Mechanical Engineering, Fuel Cell Center, Yuan Ze University, Taoyuan 300 (China)

    2011-01-15

    Commercial sized (16 x 16 cm{sup 2} active surface area) proton exchange membrane (PEM) fuel cells with serpentine flow chambers are fabricated. The GORE-TEX registered PRIMEA 5621 was used with a 35-{mu}m-thick PEM with an anode catalyst layer with 0.45 mg cm{sup -2} Pt and cathode catalyst layer with 0.6 mg cm{sup -2} Pt and Ru or GORE-TEX registered PRIMEA 57 was used with an 18-{mu}m-thick PEM with an anode catalyst layer at 0.2 mg cm{sup -2} Pt and cathode catalyst layer at 0.4 mg cm{sup -2} of Pt and Ru. At the specified cell and humidification temperatures, the thin PRIMEA 57 membrane yields better cell performance than the thick PRIMEA 5621 membrane, since hydration of the former is more easily maintained with the limited amount of produced water. Sufficient humidification at both the cathode and anode sides is essential to achieve high cell performance with a thick membrane, like the PRIMEA 5621. The optimal cell temperature to produce the best cell performance with PRIMEA 5621 is close to the humidification temperature. For PRIMEA 57, however, optimal cell temperature exceeds the humidification temperature. (author)

  11. The storage degradation of an 18650 commercial cell studied using neutron powder diffraction

    Science.gov (United States)

    Lee, Po-Han; Wu, She-huang; Pang, Wei Kong; Peterson, Vanessa K.

    2018-01-01

    Commercial 18650 lithium ion cells containing a blended positive electrode of layered LiNi0.5Mn0.3Co0.2O2 and spinel Li1.1Mn1.9O4 alongside a graphite negative electrode were stored at various depth-of-discharge (DoD) at 60 °C for 1, 2, 4, and 6 months. After storage, the cells were cycled at C/25 at 25 °C between 2.75 and 4.2 V for capacity determination and incremental capacity analysis (ICA). In addition to ICA analysis, the mechanism for capacity fade was investigated by combining the results of neutron powder diffraction under in-situ and operando conditions, in conjunction with post-mortem studies of the electrodes using synchrotron X-ray powder diffraction and inductively-coupled plasma optical emission spectroscopy. Among the cells, those stored at 25% DoD suffered the highest capacity fade due to their higher losses of active Li, NMC, and LMO than cells stored at other DoD. The cells stored at 0% DoD shows second high capacity fade because they exhibit the highest of active LMO and graphite anode among the stored cells and higher losses of active Li and NMC than cells stored at 50% DoD.

  12. Pathways to Commercial Success: Technologies and Products Supported by the Hydrogen, Fuel Cells and Infrastructure Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-08-01

    This report documents the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Hydrogen, Fuel Cells and Infrastructure Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  13. Space Communications Capability Roadmap Interim Review

    Science.gov (United States)

    Spearing, Robert; Regan, Michael

    2005-01-01

    Contents include the following: Identify the need for a robust communications and navigation architecture for the success of exploration and science missions. Describe an approach for specifying architecture alternatives and analyzing them. Establish a top level architecture based on a network of networks. Identify key enabling technologies. Synthesize capability, architecture and technology into an initial capability roadmap.

  14. A Comparative Study of Probabilistic Roadmap Planners

    NARCIS (Netherlands)

    Geraerts, R.J.; Overmars, M.H.

    2004-01-01

    The probabilistic roadmap approach is one of the leading motion planning techniques. Over the past eight years the technique has been studied by many different researchers. This has led to a large number of variants of the approach, each with its own merits. It is difficult to compare the different

  15. SCENET roadmap for superconductor digital electronics

    NARCIS (Netherlands)

    ter Brake, Hermanus J.M.; Buchholz, F.-Im.; Burnell, G.; Claeson, T.; Crete, D.; Febvre, P.; Gerritsma, G.J.; Hilgenkamp, Johannes W.M.; ............, [Unknown; Rogalla, Horst

    2006-01-01

    The roadmap gives an overview on status and future developments in Superconducting Digital Electronics (SDE). Key areas in SDE under focus are applications, circuit simulation and design, circuit fabrication, interfacing and testing, cooling and system aspects, and new devices and materials. Care

  16. Gaussian sampling for probabilistic roadmap planners

    NARCIS (Netherlands)

    Boor, V.; Overmars, M.H.; Stappen, A.F. van der

    2001-01-01

    Probabilistic roadmap planners (PRMs) have become a popular technique for motion planning that has shown great potential. A critical aspect of a PRM is the probabilistic strategy used to sample the free configuration space. In this paper we present a new, simple sampling strategy, which we call

  17. Roadmapping towards Sustainability Proficiency in Engineering Education

    Science.gov (United States)

    Rodriguez-Andara, Alejandro; Río-Belver, Rosa María; Rodríguez-Salvador, Marisela; Lezama-Nicolás, René

    2018-01-01

    Purpose: The purpose of this paper is to deliver a roadmap that displays pathways to develop sustainability skills in the engineering curricula. Design/methodology/approach: The selected approach to enrich engineering students with sustainability skills was active learning methodologies. First, a survey was carried out on a sample of 189 students…

  18. Lunar Surface Systems Supportability Technology Development Roadmap

    Science.gov (United States)

    Oeftering, Richard C.; Struk, Peter M.; Green, Jennifer L.; Chau, Savio N.; Curell, Philip C.; Dempsey, Cathy A.; Patterson, Linda P.; Robbins, William; Steele, Michael A.; DAnnunzio, Anthony; hide

    2011-01-01

    The Lunar Surface Systems Supportability Technology Development Roadmap is a guide for developing the technologies needed to enable the supportable, sustainable, and affordable exploration of the Moon and other destinations beyond Earth. Supportability is defined in terms of space maintenance, repair, and related logistics. This report considers the supportability lessons learned from NASA and the Department of Defense. Lunar Outpost supportability needs are summarized, and a supportability technology strategy is established to make the transition from high logistics dependence to logistics independence. This strategy will enable flight crews to act effectively to respond to problems and exploit opportunities in an environment of extreme resource scarcity and isolation. The supportability roadmap defines the general technology selection criteria. Technologies are organized into three categories: diagnostics, test, and verification; maintenance and repair; and scavenge and recycle. Furthermore, "embedded technologies" and "process technologies" are used to designate distinct technology types with different development cycles. The roadmap examines the current technology readiness level and lays out a four-phase incremental development schedule with selection decision gates. The supportability technology roadmap is intended to develop technologies with the widest possible capability and utility while minimizing the impact on crew time and training and remaining within the time and cost constraints of the program.

  19. Solar Thermal energy strategic road-map

    International Nuclear Information System (INIS)

    Hafner, Bernd; Godin, Olivier; Villier, Dominique; Petit, J.F.; Demangeon, Elsa; Laplagne, Valerie; Loyen, Richard; Mugnier, Daniel; Filloux, Alain; Frichet, Jean-Claude; Aubert, Elisabeth; Cherepanova, Margarita; Guilmin, Audrey; Dicostanzo, Catherine; Papillon, Philippe; Caccavelli, Dominique; Cholin, Xavier; Leger, Emmanuel; Gevaudan, Alain; Coulaud, Celine; Morlot, Rodolphe; Khebchache, Bouzid; Parrouffe, Jean-Michel; Clement, Daniel; Tonnet, Nicolas

    2012-11-01

    The French Environment and Energy Management Agency (ADEME) manages a fund dedicated to new energy technologies. Since 2008 this fund has funded 'research demonstrators' to implement testing of technologies that are in an experimental stage, between research and industrial deployment. ADEME coordinates a group of experts who are charged with drawing up a strategic road-map prior to each Call for Expressions of Interest. The aims of the solar thermal road-map are: - to highlight the industrial, technological, environmental and societal issues at stake; - to elaborate coherent, consistent and shared visions of the technologies and/or socio-technical systems outlined in the road-map; - to underscore the technological, organisational and socioeconomic barriers and bottlenecks to be overcome in order to achieve these visions; - to link priority research topics to a timetable of goals for technology availability and deployment that is consistent with the stated objectives; - to give priority to research needs and research demonstrators that will serve as the basis for: 1 - calls for expression of interest issued by the Research Demonstrators Fund, 2 - the research programming process at ADEME and more broadly at the Agence nationale de la recherche (ANR) and the Comite strategique national sur la recherche sur l'energie. Research priorities and needs for demonstrators are determined by the intersection of visions and bottlenecks. They also take into account industrial and research capacity in France. The road-maps may also refer to exemplary research demonstrators abroad that are in the forefront of technological progress, and make recommendations regarding industrial policy. These road-maps are the result of collective work by a group of experts appointed by the Steering Committee (Comite de pilotage, COPIL) of the Research Demonstrators Fund for new energy technologies. The members of this group are actors in research, drawn from industry, research bodies and research

  20. Status of commercial phosphoric acid fuel cell power plant system development

    Science.gov (United States)

    Warshay, M.

    1987-01-01

    A technology development and commercial feasibility evaluation is presented for phosphoric acid fuel cells (PAFCs) applicable to electric utility operations. The correction of identified design deficiencies in the control card and water treatment subsystems is projected to be able to substantially increase average powerplant availability from the 63 percent achieved in recent field tests of a PAFC system. Current development work is proceeding under NASA research contracts at the output levels of a multimegawatt facility for electric utility use, a multikilowatt on-site integrated energy generation facility, and advanced electrocatalysts applicable to PAFCs.

  1. The road to commercialization in Africa: lessons from developing the sickle-cell drug Niprisan.

    Science.gov (United States)

    Perampaladas, Kumar; Masum, Hassan; Kapoor, Andrew; Shah, Ronak; Daar, Abdallah S; Singer, Peter A

    2010-12-13

    Developing novel drugs from traditional medicinal knowledge can serve as a means to improve public health. Yet countries in sub-Saharan Africa face barriers in translating traditional medicinal knowledge into commercially viable health products. Barriers in moving along the road towards making a new drug available include insufficient manufacturing capacity; knowledge sharing between scientists and medical healers; regulatory hurdles; quality control issues; pricing and distribution; and lack of financing. The case study method was used to illustrate efforts to overcome these barriers during the development in Nigeria of Niprisan - a novel drug for the treatment of sickle cell anemia, a chronic blood disorder with few effective therapies. Building on the knowledge of a traditional medicine practitioner, Nigeria's National Institute for Pharmaceutical Research and Development (NIPRD) developed the traditional herbal medicine Niprisan. The commercialization of Niprisan reached a number of commercial milestones, including regulatory approval in Nigeria; securing US-based commercial partner XeChem; demonstrating clinical efficacy and safety; being awarded orphan drug status by the US Food and Drug Administration; and striking important relationships with domestic and international groups. Despite these successes, however, XeChem did not achieve mainstream success for Niprisan in Nigeria or in the United States. A number of reasons, including inconsistent funding and manufacturing and management challenges, have been put forth to explain Niprisan's commercial demise. As of this writing, NIPRD is considering options for another commercial partner to take the drug forward. Evidence from the Niprisan experience suggests that establishing benefit-sharing agreements, fostering partnerships with established research institutions, improving standardization and quality control, ensuring financial and managerial due diligence, and recruiting entrepreneurial leaders capable of

  2. The road to commercialization in Africa: lessons from developing the sickle-cell drug Niprisan

    Directory of Open Access Journals (Sweden)

    Daar Abdallah S

    2010-12-01

    Full Text Available Abstract Background Developing novel drugs from traditional medicinal knowledge can serve as a means to improve public health. Yet countries in sub-Saharan Africa face barriers in translating traditional medicinal knowledge into commercially viable health products. Barriers in moving along the road towards making a new drug available include insufficient manufacturing capacity; knowledge sharing between scientists and medical healers; regulatory hurdles; quality control issues; pricing and distribution; and lack of financing. The case study method was used to illustrate efforts to overcome these barriers during the development in Nigeria of Niprisan – a novel drug for the treatment of sickle cell anemia, a chronic blood disorder with few effective therapies. Discussion Building on the knowledge of a traditional medicine practitioner, Nigeria’s National Institute for Pharmaceutical Research and Development (NIPRD developed the traditional herbal medicine Niprisan. The commercialization of Niprisan reached a number of commercial milestones, including regulatory approval in Nigeria; securing US-based commercial partner XeChem; demonstrating clinical efficacy and safety; being awarded orphan drug status by the US Food and Drug Administration; and striking important relationships with domestic and international groups. Despite these successes, however, XeChem did not achieve mainstream success for Niprisan in Nigeria or in the United States. A number of reasons, including inconsistent funding and manufacturing and management challenges, have been put forth to explain Niprisan’s commercial demise. As of this writing, NIPRD is considering options for another commercial partner to take the drug forward. Summary Evidence from the Niprisan experience suggests that establishing benefit-sharing agreements, fostering partnerships with established research institutions, improving standardization and quality control, ensuring financial and managerial due

  3. The 14 Faces of Commercialization

    DEFF Research Database (Denmark)

    Sløk-Madsen, Stefan Kirkegaard; Ritter, Thomas

    The ultimate purpose of new product development is commercialization of the results. That is, creating returns for the investment. The authors investigate to what degree research published in Journal of Product Innovation Management has contributed to further our understanding of the concept and ......, a definition, and a further research agenda is developed. A part of the papers contribution is the application of a focus-based view on the classical New Product Development roadmap....

  4. Built Environment Wind Turbine Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Smith, J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Forsyth, T. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sinclair, K. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Oteri, F. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2012-11-01

    The market currently encourages BWT deployment before the technology is ready for full-scale commercialization. To address this issue, industry stakeholders convened a Rooftop and Built-Environment Wind Turbine Workshop on August 11 - 12, 2010, at the National Wind Technology Center, located at the U.S. Department of Energy’s National Renewable Energy Laboratory in Boulder, Colorado. This report summarizes the workshop.

  5. Comparative Study of Sulfonated and Phosphorylated Commercial Polytetrafluoroethylene (PTFE) Grafted with Styrene for Fuel Cell Application

    International Nuclear Information System (INIS)

    Abdel-Hady, E.E.; Abdel-Hamed, M.O.; El-Sharkawy, M.R.M.; ELtoony, M.M.

    2010-01-01

    The aim of this project is to develop novel, low cost high temperature membranes specifically for automotive fuel cell use. Styrene grafted commercial PTFE which carried out by simultaneous - irradiation was taken. Sulfonation was performed using chloro sulfonic acid for different times, while phosphorylation was done by two techniques. Synergistic effect was studied by carrying out sulfonation for phosphorylated styrene grafted PTFE. Mechanical investigation was performed by measuring tensile strength and thermal characterization was discussed by DSC measurements. Scanning Electron Microscopy (SEM) and Positron Annihilation Lifetime Spectroscopy (PALS) measurements were preformed to characterize the free volume properties by using fast-fast coincidence technique. While the crystallinity and the crystalline size were studied by X-ray diffraction (XRD). Water uptake and ion exchange capacity were determined prior to measure the electrical conductivity and capacitance at different frequencies to assure the availability of the membrane for using in fuel cell application.

  6. Electrical and Electrochemical Performance Characteristics of Small Commercial Li-Ion Cells

    Energy Technology Data Exchange (ETDEWEB)

    Ingersoll, D.; Nagasubramanian, G.; Roth, E.P.

    1998-12-22

    Advanced rechargeable lithium-ion batteries are presently being developed and commercialized worldwide for use in consumer electronics, military and space applications. At Sandia National Laboratories we have used different electrochemical techniques such as impedance and charge/discharge at ambient and subambient temperatures to probe the various electrochemical processes that are occurring in Li-ion cell. The purpose of this study is to identify the component that reduces the cell performance at subambient temperatures. Our impedance data suggest that while the variation in the electrolyte resistance between room temperature and {minus}20 C is negligible the anode electrolyte interfacial resistance increases by an order of magnitude in the same temperature regime. We believe that the solid electrolyte interface (SEI) layer on the carbon anode may be responsible for the increase in cell impedance. We have also evaluated the cells in hybrid mode with capacitors. High-current operation in the hybrid mode allowed fill usage of the Li-ion cell capacity at 25 C and showed a factor of 5 improvement in delivered capacity at {minus}20 C.

  7. Project materials [Commercial High Performance Buildings Project

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-01-01

    The Consortium for High Performance Buildings (ChiPB) is an outgrowth of DOE'S Commercial Whole Buildings Roadmapping initiatives. It is a team-driven public/private partnership that seeks to enable and demonstrate the benefit of buildings that are designed, built and operated to be energy efficient, environmentally sustainable, superior quality, and cost effective.

  8. Difference in influence of commercial industrial paints on microbial biofilms and planktonic cells

    Directory of Open Access Journals (Sweden)

    Grujić Sandra M.

    2017-01-01

    Full Text Available This study compares the effect of commercial industrial paints on the Escherichia coli PMFKG-F2, Proteus mirabilis PMFKG-F4 and Saccharomyces cerevisiae PMFKG-F6 planktonic cells and biofilms. A MBECTM-HTP assay and standard 96 microtiter plate assay were used to test the levels of resistance of planktonic cells and biofilms. The minimum inhibitory concentration (MIC and minimum lethal concentration (MLC of the tested substances, which affects planktonic cells and biofilms, were determined and the results were confirmed by fluorescence microscopy. Results obtained for planktonic cells were compared between them and with the results obtained for biofilms. Noticeable difference in the resistance between the biofilms and the planktonic cells on paints, was observed. The E. coli PMFKG-F2 planktonic cells showed the highest resistance in the presence of the tested substance 2 (MICp 2.5 μl/ml, while the P. mirabilis PMFKG-F4 planktonic cells showed the highest resistance in the presence of the tested substance 2 (MICp 5 μl/ml. The S. cerevisiae PMFKG-F6 planktonic cells showed the same level of resistance in the presence of the tested substances 1, 2 and 5 (MICp 0.62 μl/ml. The E. coli PMFKG-F2, P. mirabilis PMFKGF4 and S. cerevisiae PMFKG-6 biofilms showed the highest resistance in the presence of the tested substance 5 (MICb 125 μl/ml, MICb 125 μl/ml and MICb 62.5 μl/ml. The obtained results suggest that the biofilm may have a potential to be used in bioremediation of wastewater contaminated with industrial paints.

  9. Commercial materials as cathode for hydrogen production in microbial electrolysis cell.

    Science.gov (United States)

    Farhangi, Sara; Ebrahimi, Sirous; Niasar, Mojtaba Shariati

    2014-10-01

    The use of commercial electrodes as cathodes in a single-chamber microbial electrolysis cell has been investigated. The cell was operated in sequencing batch mode and the performance of the electrodes was compared with carbon cloth containing 0.5 mg Pt cm(-2). Overall H2 recovery [Formula: see text] was 66.7 ± 1.4, 58.7 ± 1.1 and 55.5 ± 1.5 % for Pt/CC, Ni and Ti mesh electrodes, respectively. Columbic efficiencies of the three cathodes were in the same range (74.8 ± 1.5, 77.6 ± 1.7 and 75.7 ± 1.2 % for Pt/CC, Ni and Ti mesh electrodes, respectively). A similar performance for the three cathodes under near-neutral pH and ambient temperature was obtained. The commercial electrodes are much cheaper than carbon cloth containing Pt. Low cost and good performance of these electrodes suggest they are suitable cathode materials for large scale application.

  10. Benchmarking of commercially available CHO cell culture media for antibody production.

    Science.gov (United States)

    Reinhart, David; Damjanovic, Lukas; Kaisermayer, Christian; Kunert, Renate

    2015-06-01

    In this study, eight commercially available, chemically defined Chinese hamster ovary (CHO) cell culture media from different vendors were evaluated in batch culture using an IgG-producing CHO DG44 cell line as a model. Medium adaptation revealed that the occurrence of even small aggregates might be a good indicator of cell growth performance in subsequent high cell density cultures. Batch experiments confirmed that the culture medium has a significant impact on bioprocess performance, but high amino acid concentrations alone were not sufficient to ensure superior cell growth and high antibody production. However, some key amino acids that were limiting in most media could be identified. Unbalanced glucose and amino acids led to high cell-specific lactate and ammonium production rates. In some media, persistently high glucose concentrations probably induced the suppression of respiration and oxidative phosphorylation, known as Crabtree effect, which resulted in high cell-specific glycolysis rates along with a continuous and high lactate production. In additional experiments, two of the eight basal media were supplemented with feeds from two different manufacturers in six combinations, in order to understand the combined impact of media and feeds on cell metabolism in a CHO fed-batch process. Cell growth, nutrient consumption and metabolite production rates, antibody production, and IgG quality were evaluated in detail. Concentrated feed supplements boosted cell concentrations almost threefold and antibody titers up to sevenfold. Depending on the fed-batch strategy, fourfold higher peak cell concentrations and eightfold increased IgG titers (up to 5.8 g/L) were achieved. The glycolytic flux was remarkably similar among the fed-batches; however, substantially different specific lactate production rates were observed in the different media and feed combinations. Further analysis revealed that in addition to the feed additives, the basal medium can make a considerable

  11. Delivery of episomal vectors into primary cells by means of commercial transfection reagents.

    Science.gov (United States)

    Han, Na Rae; Lee, Hyun; Baek, Song; Yun, Jung Im; Park, Kyu Hyun; Lee, Seung Tae

    2015-05-29

    Although episomal vectors are commonly transported into cells by electroporation, a number of electroporation-derived problems have led to the search for alternative transfection protocols, such as the use of transfection reagents, which are inexpensive and easy to handle. Polyplex-mediated transport of episomal vectors into the cytoplasm has been conducted successfully in immortalized cell lines, but no report exists of successful transfection of primary cells using this method. Accordingly, we sought to optimize the conditions for polyplex-mediated transfection for effective delivery of episomal vectors into the cytoplasm of primary mouse embryonic fibroblasts. Episomal vectors were complexed with the commercially available transfection reagents Lipofectamine 2000, FuGEND HD and jetPEI. The ratio of transfection reagent to episomal vectors was varied, and the subsequent transfection efficiency and cytotoxicity of the complexes were analyzed using flow cytometry and trypan blue exclusion assay, respectively. No cytotoxicity and the highest transfection yield were observed when the ratio of transfection reagent to episomal vector was 4 (v/wt) in the cases of Lipofectamine 2000 and FuGENE HD, and 2 in the case of jetPEI. Of the three transfection reagents tested, jetPEI showed the highest transfection efficiency without any cytotoxicity. Thus, we confirmed that the transfection reagent jetPEI could be used to effectively deliver episomal vectors into primary cells without electroporation. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  12. Mechanistic equivalent circuit modelling of a commercial polymer electrolyte membrane fuel cell

    Science.gov (United States)

    Giner-Sanz, J. J.; Ortega, E. M.; Pérez-Herranz, V.

    2018-03-01

    Electrochemical impedance spectroscopy (EIS) has been widely used in the fuel cell field since it allows deconvolving the different physic-chemical processes that affect the fuel cell performance. Typically, EIS spectra are modelled using electric equivalent circuits. In this work, EIS spectra of an individual cell of a commercial PEM fuel cell stack were obtained experimentally. The goal was to obtain a mechanistic electric equivalent circuit in order to model the experimental EIS spectra. A mechanistic electric equivalent circuit is a semiempirical modelling technique which is based on obtaining an equivalent circuit that does not only correctly fit the experimental spectra, but which elements have a mechanistic physical meaning. In order to obtain the aforementioned electric equivalent circuit, 12 different models with defined physical meanings were proposed. These equivalent circuits were fitted to the obtained EIS spectra. A 2 step selection process was performed. In the first step, a group of 4 circuits were preselected out of the initial list of 12, based on general fitting indicators as the determination coefficient and the fitted parameter uncertainty. In the second step, one of the 4 preselected circuits was selected on account of the consistency of the fitted parameter values with the physical meaning of each parameter.

  13. Codes and Standards Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The Hydrogen Codes and Standards Tech Team (CSTT) mission is to enable and facilitate the appropriate research, development, & demonstration (RD&D) for the development of safe, performance-based defensible technical codes and standards that support the technology readiness and are appropriate for widespread consumer use of fuel cells and hydrogen-based technologies with commercialization by 2020. Therefore, it is important that the necessary codes and standards be in place no later than 2015.

  14. A technology roadmap for photonics in the automobile, part 1: innovative front lighting

    Science.gov (United States)

    Berlitz, S.; Grimm, M.; Eichhorn, K.; Goetz, M.; Meyrueis, P.; Pearsall, T. P.; Reill, J.; Repetto, P.; Tupinier, L.

    2006-04-01

    Innovations in photonics technology have the potential to revolutionize both the inside and the outside of the automobile, making driving, simpler, safer, and more economical. Some of the most interesting applications areas are: lighting, communications, night vision, display, entertainment, and controls. However, the commercialization of these technologies will depend on a number of factors: cost, proven improvements in safety, economy of operation, availability of mass-produced components with high uniformity and reliability, regulations, and standards. The automotive industry recognizes the utility of a roadmap to focus all players, from basic device manufacturing and component integrators, to set manufacturers and ultimately automotive assemblers. In this paper we report on progress on an important component of this roadmap concerning adaptive front-lighting systems (AFS).

  15. Technology Roadmaps: Solar Heating and Cooling

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    The solar heating and cooling (SHC) roadmap outlines a pathway for solar energy to supply almost one sixth (18 EJ) of the world’s total energy use for both heating and cooling by 2050. This would save some 800 megatonnes of carbon dioxide (CO2) emissions per year; more than the total CO2 emissions in Germany in 2009. While solar heating and cooling today makes a modest contribution to world energy demand, the roadmap envisages that if concerted action is taken by governments and industry, solar energy could annually produce more than 16% of total final energy use for low temperature heat and nearly 17% for cooling. Given that global energy demand for heat represents almost half of the world’s final energy use – more than the combined global demand for electricity and transport – solar heat can make a significant contribution in both tackling climate change and strengthening energy security.

  16. Technology Roadmaps: Solar Heating and Cooling

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-09-06

    The solar heating and cooling (SHC) roadmap outlines a pathway for solar energy to supply almost one sixth (18 EJ) of the world's total energy use for both heating and cooling by 2050. This would save some 800 megatonnes of carbon dioxide (CO2) emissions per year; more than the total CO2 emissions in Germany in 2009. While solar heating and cooling today makes a modest contribution to world energy demand, the roadmap envisages that if concerted action is taken by governments and industry, solar energy could annually produce more than 16% of total final energy use for low temperature heat and nearly 17% for cooling. Given that global energy demand for heat represents almost half of the world's final energy use -- more than the combined global demand for electricity and transport -- solar heat can make a significant contribution in both tackling climate change and strengthening energy security.

  17. Roadmapping for improving cocoa postharvest management

    Directory of Open Access Journals (Sweden)

    Adriana del Pilar Sánchez Vargas

    2008-09-01

    Full Text Available This article presents the methodology and results which led to preparing post-harvesting technological development strategies for cocoa management which emerged from identifying problems such as deficient cocoa quality and insufficient fermentation of the beans according to international market requirements as shown in the poor technological development in Colombia’s main co-coa producing areas. This situation led to using a technological management tool such as roadmapping orientated towards for-mulating strategies for the technological development of cocoa postharvest management. The methodological process so im-plemented involved experts’ ongoing participation in enriching and validating results whilst four phases were implemented: per-formance analysis, gap analysing, structuring roadmapping and formulating cocoa postharvest technological development stra-tegies. The results obtained in this investigation were directed towards improving Colombian cocoa sector competitiveness in in-ternal and external markets.

  18. Book of Knowledge (BOK) for NASA Electronic Packaging Roadmap

    Science.gov (United States)

    Ghaffarian, Reza

    2015-01-01

    The objective of this document is to update the NASA roadmap on packaging technologies (initially released in 2007) and to present the current trends toward further reducing size and increasing functionality. Due to the breadth of work being performed in the area of microelectronics packaging, this report presents only a number of key packaging technologies detailed in three industry roadmaps for conventional microelectronics and a more recently introduced roadmap for organic and printed electronics applications. The topics for each category were down-selected by reviewing the 2012 reports of the International Technology Roadmap for Semiconductor (ITRS), the 2013 roadmap reports of the International Electronics Manufacturing Initiative (iNEMI), the 2013 roadmap of association connecting electronics industry (IPC), the Organic Printed Electronics Association (OE-A). The report also summarizes the results of numerous articles and websites specifically discussing the trends in microelectronics packaging technologies.

  19. Electrical and Electronics Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The Electrical and Electronics Technical Team’s (EETT's) mission is to enable cost-effective, smaller, lighter, and efficient power electronics and electric motors for electric traction drive systems (ETDSs) while maintaining performance of internal combustion engine (ICE)-based vehicles. The EETT also identifies technology gaps, establishes R&D targets, develops a roadmap to achieve technical targets and goals, and evaluates the R&D progress toward meeting the established R&D targets and goals.

  20. Strategic Roadmap 2024: Powering the Energy Frontier

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-05-01

    Strategic Roadmap 2024 applies our historic mission to the dynamic and evolving industry environment that includes myriad new regulations, the growing presence of interruptible and intermittent generation resources and constraints on our hydro resources. It also ties together Western’s strategy, initiatives, capital budgets and annual targets to move the agency in one direction, continue to meet customer needs and provide the best value as an organization.

  1. Astaxanthin-producing green microalga Haematococcus pluvialis: from single cell to high value commercial products

    Directory of Open Access Journals (Sweden)

    Md. Mahfuzur Rahman Shah

    2016-04-01

    Full Text Available Many species of microalgae have been used as source of nutrient rich food, feed and health promoting compounds. Among the commercially important microalgae, Haematococcus pluvialis is the richest source of natural astaxanthin which is considered as super anti-oxidant. Natural astaxanthin produced by H. pluvialis has significantly greater antioxidant capacity than the synthetic one. Astaxanthin has important applications in the nutraceuticals, cosmetics, food, and aquaculture industries. Thanks to many researches it is now evident, that astaxanthin can significantly reduce free radicals and oxidative stress and help human body maintain a healthy state. With extraordinary potency and increase in demand, astaxanthin is one of the high-value microalgal products of the future. Thus, this comprehensive review summarizes the most important aspects of the biology, biochemical composition, biosynthesis and astaxanthin accumulation in the cells of H. pluvialis and its wide range of applications for humans and animals. In this paper, important and recent developments ranging from cultivation, harvest and postharvest bio-processing technologies to metabolic control and genetic engineering are reviewed in detail, focusing on biomass and astaxanthin production from this biotechnologically important microalga. Simultaneously, critical bottlenecks and major challenges in commercial scale production; current and prospective global market of H. pluvialis derived astaxanthin are also presented in a critical manner. A new biorefinery concept for H. pluvialis has been also suggested to guide towards economically sustainable approach for microalgae cultivation and processing. This report could serve as a useful guide to present current status of knowledge in the field and highlight key areas for future development of H. pluvialis astaxanthin technology and its large scale commercial implementation.

  2. Astaxanthin-Producing Green Microalga Haematococcus pluvialis: From Single Cell to High Value Commercial Products.

    Science.gov (United States)

    Shah, Md Mahfuzur R; Liang, Yuanmei; Cheng, Jay J; Daroch, Maurycy

    2016-01-01

    Many species of microalgae have been used as source of nutrient rich food, feed, and health promoting compounds. Among the commercially important microalgae, Haematococcus pluvialis is the richest source of natural astaxanthin which is considered as "super anti-oxidant." Natural astaxanthin produced by H. pluvialis has significantly greater antioxidant capacity than the synthetic one. Astaxanthin has important applications in the nutraceuticals, cosmetics, food, and aquaculture industries. It is now evident that, astaxanthin can significantly reduce free radicals and oxidative stress and help human body maintain a healthy state. With extraordinary potency and increase in demand, astaxanthin is one of the high-value microalgal products of the future.This comprehensive review summarizes the most important aspects of the biology, biochemical composition, biosynthesis, and astaxanthin accumulation in the cells of H. pluvialis and its wide range of applications for humans and animals. In this paper, important and recent developments ranging from cultivation, harvest and postharvest bio-processing technologies to metabolic control and genetic engineering are reviewed in detail, focusing on biomass and astaxanthin production from this biotechnologically important microalga. Simultaneously, critical bottlenecks and major challenges in commercial scale production; current and prospective global market of H. pluvialis derived astaxanthin are also presented in a critical manner. A new biorefinery concept for H. pluvialis has been also suggested to guide toward economically sustainable approach for microalgae cultivation and processing. This report could serve as a useful guide to present current status of knowledge in the field and highlight key areas for future development of H. pluvialis astaxanthin technology and its large scale commercial implementation.

  3. Technology Roadmap: Wind Energy. 2013 edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    The IEA Wind Power Technology Roadmap 2013 Edition recognises the very significant progress made since the first edition was published in 2009. The technology continues to improve rapidly, and costs of generation from land-based wind installations continue to fall. Wind power is now being deployed in countries with good resources without any dedicated financial incentives. The 2013 Edition targets an increased share (15% to 18%) of global electricity to be provided by wind power in 2050, compared to 12% in the original roadmap of 2009. However, increasing levels of low-cost wind still require predictable, supportive regulatory environments and appropriate market designs. The challenges of integrating higher levels of variable wind power into the grid need to be addressed. For offshore wind, much remains to be done to develop appropriate large-scale systems and to reduce costs. The 2013 Wind Power Roadmap also provides updated analysis on the barriers that exist for the technology and suggests ways to address them, including legal and regulatory recommendations.

  4. A roadmap towards personalized immunology

    OpenAIRE

    Delhalle, Sylvie; Bode, Sebastian F. N.; Balling, Rudi; Ollert, Markus; He, Feng Q.

    2018-01-01

    Big data generation and computational processing will enable medicine to evolve from a “one-size-fits-all” approach to precise patient stratification and treatment. Significant achievements using “Omics” data have been made especially in personalized oncology. However, immune cells relative to tumor cells show a much higher degree of complexity in heterogeneity, dynamics, memory-capability, plasticity and “social” interactions. There is still a long way ahead on translating our capability to ...

  5. A roadmap towards personalized immunology

    OpenAIRE

    Delhalle, Sylvie; Bode, Sebastian F N; Balling, Rudi; Ollert, Markus; He, Feng Q

    2018-01-01

    Big data generation and computational processing will enable medicine to evolve from a "one-size-fits-all" approach to precise patient stratification and treatment. Significant achievements using "Omics" data have been made especially in personalized oncology. However, immune cells relative to tumor cells show a much higher degree of complexity in heterogeneity, dynamics, memory-capability, plasticity and "social" interactions. There is still a long way ahead on translating our capability to ...

  6. Challenges Considering the Degradation of Cell Components in Commercial Lithium-Ion Cells: A Review and Evaluation of Present Systems.

    Science.gov (United States)

    Kleiner, Karin; Ehrenberg, Helmut

    2017-06-01

    individual cell components. Although the degradation of materials is the key consideration in achieving lower costs, a higher safety standard, higher energy densities and a longer lifetime, the degradation of the individual cell components in dependence on the operation conditions has hardly been investigated and is poorly understood. The present work reviews known material degradations in commercial lithium-ion cells, shows a way to analyze such degradations in dependence on the operation conditions and describes how these degradation processes lead to observed performance drops.

  7. A consortium approach to commercialized Westinghouse solid oxide fuel cell technology

    Science.gov (United States)

    Casanova, Allan

    Westinghouse is developing its tubular solid oxide fuel cells (SOFCs) for a variety of applications in stationary power generation markets. By pressurizing a SOFC and integrating it with a gas turbine (GT), power systems with efficiencies as high as 70-75% can be obtained. The first such system will be tested in 1998. Because of their extraordinarily high efficiency (60-70%) even in small sizes the first SOFC products to be offered are expected to be integrated SOFC/GT power systems in the 1-7 MW range, for use in the emerging distributed generation (DG) market segment. Expansion into larger sizes will follow later. Because of their modularity, environmental friendliness and expected cost effectiveness, and because of a worldwide thrust towards utility deregulation, a ready market is forecasted for baseload distributed generation. Assuming Westinghouse can complete its technology development and reach its cost targets, the integrated SOFC/GT power system is seen as a product with tremendous potential in the emerging distributed generation market. While Westinghouse has been a leader in the development of power generation technology for over a century, it does not plan to manufacture small gas turbines. However, GTs small enough to integrate with SOFCs and address the 1-7 MW market are generally available from various manufacturers. Westinghouse will need access to a new set of customers as it brings baseload plants to the present small market mix of emergency and peaking power applications. Small cogeneration applications, already strong in some parts of the world, are also gaining ground everywhere. Small GT manufacturers already serve this market, and alliances and partnerships can enhance SOFC commercialization. Utilities also serve the DG market, especially those that have set up energy service companies and seek to grow beyond the legal and geographical confines of their current regulated business. Because fuel cells in general are a new product, because small

  8. Hydrogen Delivery Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The mission of the Hydrogen Delivery Technical Team (HDTT) is to enable the development of hydrogen delivery technologies, which will allow for fuel cell competitiveness with gasoline and hybrid technologies by achieving an as-produced, delivered, and dispensed hydrogen cost of $2-$4 per gallon of gasoline equivalent of hydrogen.

  9. Development of a platform for roadmapping nanotechnology for energy

    International Nuclear Information System (INIS)

    Sarwqar, Mohammad Sohail

    2004-02-01

    This report includes the vision for global energy sector to develop a highly reliable, economically viable, and environmentally benign power generation and delivery systems with the help of nanotechnology. This scenario will provide indispensable public services and sustain the economic growth. The need to take advantage of the science of ultra-small scales such as nanotechnology is emphasized. The application of nanotechnology in future energy systems, specially the advanced renewables (photovoltaics, fuel cells, etc) are explained in a systematic and organized manner. The role of nanotechnology for the ubiquitous digital society and minimal carbon emissions (clean environment) with the help of nanotechnology is also envisioned. This report attempts to roadmap nanotechnology for energy through to 2030

  10. A comparison of solar photovoltaics and molten carbonate fuel cells as commercial power plants

    International Nuclear Information System (INIS)

    Wee, Jung-Ho; Roh, Jae Hyung; Kim, Jeongin

    2011-01-01

    In line with the worldwide trend, Korea has recognized the importance of renewable energy and extensively supported its exploitation. As of August 2009, the largest incentives for renewable energy are offered to solar photovoltaic (PV) systems, which have vastly increased the installations of this system. On the basis of total paid incentives, the second largest beneficiary is the fuel cell (FC) system. This support has contributed to the successful commercialization of the molten carbonate FC (MCFC) as a distributed generation system (DG). Considering the status of energy systems in Korea, solar PV and MCFC systems are likely to be further developed in the country. The present paper analyzes the exploitation of these two energy systems by conducting a feasibility study and a technology assessment in the Korea environment based on many assumptions, conditions and data involved. The feasibility study demonstrates the positive economic gains of the solar PV and MCFC power plants. The unit electricity generation cost of solar PV is twice that of an MCFC system. In addition, the study reveals the slightly greater profitability of the MCFC. Exact estimation of their future economies is impossible because of uncertainties in many future conditions and environments. Nevertheless, the development of solar cells with higher efficiency is undoubtedly the most critical factor in increasing future profits. On the other hand, reductions in the operation and maintenance (O and M) costs and the natural gas (NG) price are the most important issues in raising the viability of the MCFC system. (author)

  11. Breaking down the barriers to commercialization of fuel cells in transportation through Government - industry R&D programs

    Energy Technology Data Exchange (ETDEWEB)

    Chalk, S.G. [Dept. of Energy, Washington, DC (United States); Venkateswaran, S.R. [Energetics, Inc., Columbia, MD (United States)

    1996-12-31

    PEM fuel cell technology is rapidly emerging as a viable propulsion alternative to the internal combustion engine. Fuel cells offer the advantages of low emissions, high efficiency, fuel flexibility, quiet and continuous operation, and modularity. Over the last decade, dramatic advances have been achieved in the performance and cost of PEM fuel cell technologies for automotive applications. However, significant technical barriers remain to making fuel cell propulsion systems viable alternatives to the internal combustion engine. This paper focuses on the progress achieved and remaining technical barriers while highlighting Government-industry R&D efforts that are accelerating fuel cell technology toward commercialization.

  12. Employing Hot Wire Anemometry to Directly Measure the Water Balance of a Commercial Proton Exchange Membrane Fuel Cell Stack

    DEFF Research Database (Denmark)

    Shakhshir, Saher Al; Berning, Torsten

    2016-01-01

    Proton exchange membrane fuel cells (PEMFC’s) are currently being commercialized for various applications ranging from automotive (e.g. the Toyota Mirai) to stationary such as powering telecom backup units. In PEMFC’s, oxygen from air is internally combined with hydrogen to form water and produce...... and increased degradation rates. Clearly, a fundamental understanding of all aspects of water management in PEMFC is imperative. This includes the fuel cell water balance, i.e. which fraction of the product water leaves the fuel cell via the anode channels versus the cathode channel. Our research group...... is currently developing a novel technique to obtain an ad-hoc and real time electrical signal of the fuel cell water balance by employing hot wire anemometry. In this work, the hot wire sensor is placed in the anode outlet of a commercial air-cooled fuel cell stack by Ballard Power Systems, and the voltage...

  13. Carbon Dioxide Utilization (CO2U) ICEF Roadmap 2.0. Draft October 2017

    Energy Technology Data Exchange (ETDEWEB)

    Sandalow, D; Aines, R; Friedmann, J; McCormick, C; McCoy, S

    2017-10-02

    Last year, experts from CO2 Sciences, Columbia University and Valence Strategic came together to develop a roadmap. That document, Carbon Dioxide Utilization ICEF Roadmap 1.0, released at the UNFCCC Marrakesh Climate Change Conference in 2016, surveyed the commercial and technical landscape of CO2 conversion and use. The document provided extensive background and analysis and has helped to provide a foundation for additional studies, including this one.This roadmap is meant to complement and expand upon the work of its predecessor. Based in part on a workshop at Columbia University’s Center on Global Energy Policy in July 2017, it explores three distinct categories of CO2-based products, the technologies that can be harnessed to convert CO2 to these products, and the associated research and development needs. It also explores the complicated topic of life cycle analysis—critically important when considering the climate impacts of CO2 conversion and use—as well as policy tools that could be used to promote CO2-based products.

  14. Idaho National Engineering Laboratory installation roadmap document. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-30

    The roadmapping process was initiated by the US Department of Energy`s office of Environmental Restoration and Waste Management (EM) to improve its Five-Year Plan and budget allocation process. Roadmap documents will provide the technical baseline for this planning process and help EM develop more effective strategies and program plans for achieving its long-term goals. This document is a composite of roadmap assumptions and issues developed for the Idaho National Engineering Laboratory (INEL) by US Department of Energy Idaho Field Office and subcontractor personnel. The installation roadmap discusses activities, issues, and installation commitments that affect waste management and environmental restoration activities at the INEL. The High-Level Waste, Land Disposal Restriction, and Environmental Restoration Roadmaps are also included.

  15. Chemicals Industry New Process Chemistry Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2000-08-01

    The Materials Technology I workshop was held in November 1998 to address future research needs for materials technology that will support the chemical industry. Areas covered included disassembly, recovery, reuse and renewable technology; new materials; and materials measurement and characterization. The Materials Technology II workshop was held in September 1999 and covered additives, modeling and prediction and an additional segment on new materials. Materials Technology Institute (MTI) for the Chemical Process Industries, Inc. and Air Products & Chemicals lead the workshops. The Materials Technology Roadmap presents the results from both workshops.

  16. A quality roadmap of a restructured hospital.

    Science.gov (United States)

    Chow-Chua, C F; Goh, M

    1999-09-01

    This paper presents a quality roadmap of a restructured hospital. Specifically, a case study is showcased to reveal how a FOCUS-PDCA model is applied to the Central Portering Services (CPS) within a restructured hospital, to provide better service to other departments within the hospital who can then in turn value add to the patient care delivery chain. The preliminary results suggest that implementers of quality and service improvement programmes using the FOCUS-PDCA approach should note some of the key implementation difficulties. These difficulties occur at all levels and include issues relevant to change management, process improvement programmes, accessibility to data, communication and judicious execution of the change process.

  17. Challenges & Roadmap for Beyond CMOS Computing Simulation.

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Arun F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Frank, Michael P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-12-01

    Simulating HPC systems is a difficult task and the emergence of “Beyond CMOS” architectures and execution models will increase that difficulty. This document presents a “tutorial” on some of the simulation challenges faced by conventional and non-conventional architectures (Section 1) and goals and requirements for simulating Beyond CMOS systems (Section 2). These provide background for proposed short- and long-term roadmaps for simulation efforts at Sandia (Sections 3 and 4). Additionally, a brief explanation of a proof-of-concept integration of a Beyond CMOS architectural simulator is presented (Section 2.3).

  18. Successful user experience strategy and roadmaps

    CERN Document Server

    Rosenzweig, Elizabeth

    2015-01-01

    Successful User Experience: Strategy and Roadmaps provides you with a hands-on guide for pulling all of the User Experience (UX) pieces together to create a strategy that includes tactics, tools, and methodologies. Leveraging material honed in user experience courses and over 25 years in the field, the author explains the value of strategic models to refine goals against available data and resources. You will learn how to think about UX from a high level, design the UX while setting goals for a product or project, and how to turn that into concrete actionable steps. After reading this book, y

  19. Development of comprehensive technology of phosphoric acid fuel cell. Research and development of commercial fuel cell power generation system

    Energy Technology Data Exchange (ETDEWEB)

    1987-09-01

    The purpose of this study is to develop a down-sized, easy operation phosphoric acid fuel cell power generation system as a commercial on-site power source for hotel and hospital and to operate the system. The five-year program was initiated in 1986. In FY 1986, the component research such as the moulding process of sheet matrix and electrode for thinner cell and the determination of performance of heat pipe cooler were made. The structure of down-sized reformer and heat-exchanger were investigated. The three-dimensional impeller, material of impeller, gaseous bearing and the structure of soundproof package of the high-performance turbo compressor were studied to determine the basic structure. Hotel A with the floor space of appromixately 50,000 m/sup 2/ was selected to install the system and the demands of power and heat were surveyed. The specifications of a 200 kW-outdoor system were developed based on those results. (2 tabs)

  20. Grafting of Styrene onto Commercial Polytetrafluorethylene (PTFE) Membrane and Sulfonation for Possible use in Fuel Cell

    International Nuclear Information System (INIS)

    Abdel-Hady, E.E.; Abdel-Hamed, M.O.; Hammam, A.M.; El-toony, M.M.

    2010-01-01

    The purpose of this work is to initiate the fundamental research necessary for the development of a novel proton-exchange membranes (PEM) to overcome the material and performance limitations of the s tate of the art N afion that is used in both hydrogen and methanol fuel cells. Silica was inserted in commercial PTFE membrane in ratio 8%. Gamma irradiation was used for grafting of different ratios of styrene onto the membrane in one and two steps. Methacrylic acid and styrene were used as binary monomers for grafting of such membranes to raise the grafting percentage. Thermal characterization of the grafted membrane was discussed using thermal gravimetric analysis (TGA). The mechanical properties were tested by measuring ultimate tensile value, and Young modulus. The positron annihilation lifetime spectroscopy has been used to investigate the free volume hole size, while the surface morphology of the membrane was studied by scanning electron microscope (SEM). It was found that the maximum water uptake of the sulfonated membrane reached 20% by weight. The proton conductivity of the prepared polymer electrolyte was measured by ac impedance spectroscopic analysis. And it was found to be 0.9 x 10 -4 ohm -1 cm -1 .

  1. Research and Development of Zinc Air Fuel Cell To Achieve Commercialization Final Report CRADA No. TC-1544-98

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, J. F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Haley, H. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-09-28

    The specific goal of this project was to advance the development of the zinc air fuel cell (ZAFC) towards commercial readiness in different mobile applications, including motor bikes, passenger cars, vans, buses and off-road vehicles (golf carts, factory equipment), and different stationary applications including generator sets, uninterruptible power systems and electric utility loading leveling and distributive power.

  2. Program of scientific investigations and development of solid-oxide fuel cells (SOFC) in VIITF proposals on scientific and technical collaboration and SOFC commercialization

    Energy Technology Data Exchange (ETDEWEB)

    Kleschev, Yu.N.; Chulharev, V.F.

    1996-04-01

    Investigations being performed at VNIITF covers the whole cycle of solid oxide fuel cell manufacturing. This report describes the main directions of investigations in materials, technologies, and commercialization.

  3. Built-Environment Wind Turbine Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Smith, J.; Forsyth, T.; Sinclair, K.; Oteri, F.

    2012-11-01

    Although only a small contributor to total electricity production needs, built-environment wind turbines (BWTs) nonetheless have the potential to influence the public's consideration of renewable energy, and wind energy in particular. Higher population concentrations in urban environments offer greater opportunities for project visibility and an opportunity to acquaint large numbers of people to the advantages of wind projects on a larger scale. However, turbine failures will be equally visible and could have a negative effect on public perception of wind technology. This roadmap provides a framework for achieving the vision set forth by the attendees of the Built-Environment Wind Turbine Workshop on August 11 - 12, 2010, at the U.S. Department of Energy's National Renewable Energy Laboratory. The BWT roadmap outlines the stakeholder actions that could be taken to overcome the barriers identified. The actions are categorized as near-term (0 - 3 years), medium-term (4 - 7 years), and both near- and medium-term (requiring immediate to medium-term effort). To accomplish these actions, a strategic approach was developed that identifies two focus areas: understanding the built-environment wind resource and developing testing and design standards. The authors summarize the expertise and resources required in these areas.

  4. Technology Roadmaps: Carbon Capture and Storage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    Carbon capture and storage (CCS) is an important part of the lowest-cost greenhouse gas (GHG) mitigation portfolio. IEA analysis suggests that without CCS, overall costs to reduce emissions to 2005 levels by 2050 increase by 70%. This roadmap includes an ambitious CCS growth path in order to achieve this GHG mitigation potential, envisioning 100 projects globally by 2020 and over 3000 projects by 2050. This roadmap's level of project development requires an additional investment of over USD 2.5-3 trillion from 2010 to 2050, which is about 6% of the overall investment needed to achieve a 50% reduction in GHG emissions by 2050. OECD governments will need to increase funding for CCS demonstration projects to an average annual level of USD 3.5 to 4 billion (bn) from 2010 to 2020. In addition, mechanisms need to be established to incentivise commercialisation beyond 2020 in the form of mandates, GHG reduction incentives, tax rebates or other financing mechanisms.

  5. NASA Net Zero Energy Buildings Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Pless, S.; Scheib, J.; Torcellini, P.; Hendron, B.; Slovensky, M.

    2014-10-01

    In preparation for the time-phased net zero energy requirement for new federal buildings starting in 2020, set forth in Executive Order 13514, NASA requested that the National Renewable Energy Laboratory (NREL) to develop a roadmap for NASA's compliance. NASA detailed a Statement of Work that requested information on strategic, organizational, and tactical aspects of net zero energy buildings. In response, this document presents a high-level approach to net zero energy planning, design, construction, and operations, based on NREL's first-hand experience procuring net zero energy construction, and based on NREL and other industry research on net zero energy feasibility. The strategic approach to net zero energy starts with an interpretation of the executive order language relating to net zero energy. Specifically, this roadmap defines a net zero energy acquisition process as one that sets an aggressive energy use intensity goal for the building in project planning, meets the reduced demand goal through energy efficiency strategies and technologies, then adds renewable energy in a prioritized manner, using building-associated, emission- free sources first, to offset the annual energy use required at the building; the net zero energy process extends through the life of the building, requiring a balance of energy use and production in each calendar year.

  6. Technology Roadmap: Carbon Capture and Storage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-01

    As long as fossil fuels and carbon-intensive industries play dominant roles in our economies, carbon capture and storage (CCS) will remain a critical greenhouse gas reduction solution. This CCS roadmap aims at assisting governments and industry in integrating CCS in their emissions reduction strategies and in creating the conditions for scaled-up deployment of all three components of the CCS chain: CO2 capture, transport and storage. To get us onto the right pathway, this roadmap highlights seven key actions needed in the next seven years to create a solid foundation for deployment of CCS starting by 2020. IEA analysis shows that CCS is an integral part of any lowest-cost mitigation scenario where long-term global average temperature increases are limited to significantly less than 4 °C, particularly for 2 °C scenarios (2DS). In the 2DS, CCS is widely deployed in both power generation and industrial applications. The total CO2 capture and storage rate must grow from the tens of megatonnes of CO2 captured in 2013 to thousands of megatonnes of CO2 in 2050 in order to address the emissions reduction challenge. A total cumulative mass of approximately 120 GtCO2 would need to be captured and stored between 2015 and 2050, across all regions of the globe.

  7. Transformational Spaceport and Range Capabilities Roadmap Interim Review to National Research Council External Review Panel

    Science.gov (United States)

    Poniatowski, Karen

    2005-01-01

    Contents include the following: Overview/Introduction. Roadmap Approach/Considerations. Roadmap Timeline/Spirals. Requirements Development. Spaceport/Range Capabilities. Mixed Range Architecture. User Requirements/Customer Considerations. Manifest Considerations. Emerging Launch User Requirements. Capability Breakdown Structure/Assessment. Roadmap Team Observations. Transformational Range Test Concept. Roadmap Team Conclusions. Next Steps.

  8. Design of serum-free medium for suspension culture of CHO cells on the basis of general commercial media.

    Science.gov (United States)

    Miki, Hideo; Takagi, Mutsumi

    2015-08-01

    The design of serum-free media for suspension culture of genetically engineered Chinese hamster ovary (CHO) cells using general commercial media as a basis was investigated. Subcultivation using a commercial serum-free medium containing insulin-like growth factor (IGF)-1 with or without FCS necessitated additives other than IGF-1 to compensate for the lack of FCS and improve cell growth. Suspension culture with media containing several combinations of growth factors suggested the effectiveness of addition of both IGF-1 and the lipid signaling molecule lysophosphatidic acid (LPA) for promoting cell growth. Subcultivation of CHO cells in suspension culture using the commercial serum-free medium EX-CELL™302, which contained an IGF-1 analog, supplemented with LPA resulted in gradually increasing specific growth rate comparable to the serum-containing medium and in almost the same high antibody production regardless of the number of generations. The culture with EX-CELL™302 supplemented with LPA in a jar fermentor with pH control at 6.9 showed an apparently higher cell growth rate than the cultures without pH control and with pH control at 6.8. The cell growth in the medium supplemented with aurintricarboxylic acid (ATA), which was much cheaper than IGF-1, in combination with LPA was synergistically promoted similarly to that in the medium supplemented with IGF-1 and LPA. In conclusion, the serum-free medium designed on the basis of general commercial media could support the growth of CHO cells and antibody production comparable to serum-containing medium in suspension culture. Moreover, the possibility of cost reduction by the substitution of IGF-1 with ATA was also shown.

  9. Technology Roadmap Research Program for the Steel Industry

    Energy Technology Data Exchange (ETDEWEB)

    Joseph R. Vehec

    2010-12-30

    The steel industry's Technology Roadmap Program (TRP) is a collaborative R&D effort jointly sponsored by the steel industry and the United States Department of Energy. The TRP program was designed to develop new technologies to save energy , increase competitiveness, and improve the environment. TRP ran from July, 1997 to December, 2008, with a total program budget of $38 million dollars. During that period 47 R&D projects were performed by 28 unique research organizations; co-funding was provided by DOE and 60 industry partners. The projects benefited all areas of steelmaking and much know-how was developed and transferred to industry. The American Iron and Steel Institute is the owner of all intellectual property developed under TRP and licenses it at commercial rates to all steelmakers. TRP technologies are in widespread use in the steel industry as participants received royalty-free use of intellectual property in return for taking the risk of funding this research.

  10. Technology Roadmap for the 21st Century Truck Program, a government-industry research partnership

    Energy Technology Data Exchange (ETDEWEB)

    None

    2000-12-01

    The 21st Century Truck Program has been established as a government-industry research partnership to support the development and implementation of commercially viable technologies that will dramatically cut fuel use and emissions of commercial trucks and buses while enhancing their safety and affordability as well as maintaining or enhancing performance. The innovations resulting from this program will reduce dependence on foreign oil, improve our nation's air quality, provide advanced technology for military vehicles, and enhance the competitiveness of the U.S. truck and bus industry while ensuring safe and affordable freight and bus transportation for the nation's economy. This Technology Roadmap for the 21st Century Truck Program has been prepared to guide the development of the technical advancements that will enable the needed improvements in commercial truck fuel economy, emissions, and safety.

  11. Technology roadmapping for strategy and innovation charting the route to success

    CERN Document Server

    Isenmann, Ralf; Phaal, Robert

    2013-01-01

    Technology roadmapping is a core method to help companies and other organisations gain orientation for future opportunities and changes. This book is a key resource for technology roadmapping – it provides expert knowledge in four areas: To frame/embed technology roadmapping To structure the process and tasks of technology roadmapping To implement technology roadmapping into corporate strategies To link technology roadmapping to further instruments of strategic planning and corporate foresight This comprehensive survey of technology roadmapping includes papers from leading European, American and Asian experts: It provides an overview of different methods of technology roadmapping and the interactions between them It familiarises readers with the most important sub-methods It embeds/links technology roadmapping to the overall framework of management research and business studies This book, the first of a series, is unique: it aims to become the leading compendium for technology roadmapping knowledge and prac...

  12. The European Hematology Association Roadmap for European Hematology Research: a consensus document.

    Science.gov (United States)

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    2016-02-01

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. Copyright© Ferrata Storti Foundation.

  13. Building a CAR Garage: Preparing for the Delivery of Commercial CAR T Cell Products at Memorial Sloan Kettering Cancer Center.

    Science.gov (United States)

    Perica, Karlo; Curran, Kevin J; Brentjens, Renier J; Giralt, Sergio A

    2018-03-01

    Two commercial chimeric antigen receptor (CAR) T cell therapies for CD19-expressing B cell malignancies, Kymriah and Yescarta, have recently been approved by the Food and Drug Administration. The administration of CAR T cells is a complex endeavor involving cell manufacture, tracking and shipping of apheresis products, and management of novel and severe toxicities. At Memorial Sloan Kettering Cancer Center, we have identified 8 essential tasks that define the CAR T cell workflow. In this review, we discuss practical aspects of CAR T cell program development, including clinical, administrative, and regulatory challenges for successful implementation. Copyright © 2018 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  14. Idaho National Engineering Laboratory Waste Management Operations Roadmap Document

    International Nuclear Information System (INIS)

    Bullock, M.

    1992-04-01

    At the direction of the Department of Energy-Headquarters (DOE-HQ), the DOE Idaho Field Office (DOE-ID) is developing roadmaps for Environmental Restoration and Waste Management (ER ampersand WM) activities at Idaho National Engineering Laboratory (INEL). DOE-ID has convened a select group of contractor personnel from EG ampersand G Idaho, Inc. to assist DOE-ID personnel with the roadmapping project. This document is a report on the initial stages of the first phase of the INEL's roadmapping efforts

  15. Critical Issues in the Commercialization of DMFC and Role of Membranes

    Science.gov (United States)

    Chang, Hyuk; Kim, Haekyoung; Choi, Yeong Suk; Lee, Wonmok

    Mobile telecommunication devices in the next generation require a new concept of quick charging and a long-lasting mobile energy source. The direct methanol fuel cell (DMFC) is becoming attractive, but there are critical issues involved in its commercialization with regard to the core technologies of catalyst, membrane, membrane electrode assembly (MEA), stack, and system. More importantly, the main role of the proton-conducting membrane is enhancing the energy and power density and affecting the other components in DMFC systems. Functions, current status, and technical approaches are discussed in terms of protonic conductivity, methanol permeability, water permeability, life cycle, and processing cost as well as interaction with other compartments. Materials such as perfluorinated and partially fluorinated membranes, hydrocarbon membranes, composite membranes, and other modified ionomers have been studied in connection with technology roadmap of membrane and mobile DMFC systems. These would explain the critical issues of DMFC and the role of membranes for commercialization.

  16. 'Mini'-Roadmapping - Ensuring Timely Sites' Cleanup/Closure by Resolving Science and Technology Issues

    International Nuclear Information System (INIS)

    Luke, D.E.; Dixon, B.W.; Murphy, J.A.

    2003-01-01

    Roadmapping is a powerful tool to manage technical risks and opportunities associated with complex problems. Roadmapping identifies technical capabilities required for both project- and program-level efforts and provides the basis for plans that ensure the necessary enabling activities will be done when needed. Roadmapping reveals where to focus further development of the path forward by evaluating uncertainties for levels of complexity, impacts, and/or the potential for large payback. Roadmaps can be customized to the application, a ''graded approach'' if you will. Some roadmaps are less detailed. We have called these less detailed, top-level roadmaps ''mini-roadmaps''. These mini roadmaps are created to tie the needed enablers (e.g., technologies, decisions, etc.) to the functions. If it is found during the mini-roadmapping that areas of significant risk exist, then those can be roadmapped further to a lower level of detail. Otherwise, the mini-roadmap may be sufficient to manage the project/program risk. Applying a graded approach to the roadmapping can help keep the costs down. Experience has indicated that it is best to do mini-roadmapping first and then evaluate the risky areas to determine whether to further evaluate those areas. Roadmapping can be especially useful for programs/projects that have participants from multiple sites, programs, or other entities which are involved. Increased synergy, better communications, and increased cooperation are the results from roadmapping a program/project with these conditions

  17. A Roadmap of Innovative Nuclear Energy System

    Science.gov (United States)

    Sekimoto, Hiroshi

    2017-01-01

    Nuclear is a dense energy without CO2 emission. It can be used for more than 100,000 years using fast breeder reactors with uranium from the sea. However, it raises difficult problems associated with severe accidents, spent fuel waste and nuclear threats, which should be solved with acceptable costs. Some innovative reactors have attracted interest, and many designs have been proposed for small reactors. These reactors are considered much safer than conventional large reactors and have fewer technical obstructions. Breed-and-burn reactors have high potential to solve all inherent problems for peaceful use of nuclear energy. However, they have some technical problems with materials. A roadmap for innovative reactors is presented herein.

  18. Background paper on Technology Roadmaps (TRMs)

    Energy Technology Data Exchange (ETDEWEB)

    More, E.; Phaal, R. [Institute for Manufacturing IfM, Department of Engineering, University of Cambridge, Cambridge (United Kingdom); Londo, H.M.; Wurtenberger, L.; Cameron, L.R. [ECN Policy Studies, Amsterdam (Netherlands)

    2013-04-15

    This background paper reports on the use of technology roadmaps (TRMs) related to climate change mitigation and adaptation technologies. The study is motivated by the UNFCCC Conference of the Parties (CoP) request to the Technology Executive Committee (TEC) to catalyse the development and use of TRMs as facilitative tools for action on mitigation and adaptation. Having originated in industry, TRMs are now used extensively in policy settings too, however their widespread use across sectors and by different stakeholders has resulted in a lack of understanding of their real value to help catalyse cooperation towards technological solutions to the problems presented by climate change. Consequently this background paper presents (1) an overview of different TRM methods, (2) an initial analysis of gaps and barriers in existing TRMs, and (3) a review of current TRM good practices.

  19. Roadmapping Future E-Government Research

    Science.gov (United States)

    Bicking, Melanie

    Global electronic markets, virtual organisations, virtual identities, virtual products and services, and Internet-related crime are growing in prominence and importance. In a world that is increasingly non-physical and borderless, what are government's roles, responsibilities and limitations? The Internet plays a central role within the transformation process from traditional governments towards modern and innovative government that the requirements of an Information Society. Based on the findings of the eGovRTD2020 project, that aims at identifying key research challenges and at implementing a model for a holistic government with horizon 2020, this paper explains the necessity to investigate and understand the Internet and in particular government's role and responsibilities in it. Furthermore, the paper provides a research roadmap that details how to address certain issue related research questions.

  20. Roadmap ICT 2030; Routekaart ICT 2030

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-06-15

    Extra attention for 'ICT and energy' can lead to significant energy savings, both in the ICT sector (Greening of ICT), as in other sectors (Greening by ICT). That has been elaborated as a vision of ICT Office in this roadmap. Actions are formulated to get started. Innovations and measures are connected to energy saving targets [Dutch] Extra aandacht voor 'ICT en energie' kan leiden tot grote energiebesparingen, zowel in de ICT sector zelf (Greening of ICT), als in andere sectoren (Greening by ICT). Dat is in deze Routekaart als visie van ICT-Office uitgewerkt. Acties zijn geformuleerd om daadwerkelijk aan de slag te kunnen gaan. Aan de innovaties en maatregelen zijn doelstellingen ten aanzien van energiebesparing gekoppeld, die zijn vertaald naar concrete bedragen.

  1. Roadmap to the SRS computing architecture

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, A.

    1994-07-05

    This document outlines the major steps that must be taken by the Savannah River Site (SRS) to migrate the SRS information technology (IT) environment to the new architecture described in the Savannah River Site Computing Architecture. This document proposes an IT environment that is {open_quotes}...standards-based, data-driven, and workstation-oriented, with larger systems being utilized for the delivery of needed information to users in a client-server relationship.{close_quotes} Achieving this vision will require many substantial changes in the computing applications, systems, and supporting infrastructure at the site. This document consists of a set of roadmaps which provide explanations of the necessary changes for IT at the site and describes the milestones that must be completed to finish the migration.

  2. DOE Science Networking Challenge: Roadmap to 2008

    Energy Technology Data Exchange (ETDEWEB)

    R. Roy Whitney; Larry Price

    2003-06-01

    This report establishes a roadmap for a new approach to the DOE Science Networking and Services needed for science in the U.S. Department of Energy in the 21st century. It has become increasingly clear 2 that the network provided for DOE science in the past will not be adequate to keep that science competitive in the future. This roadmap, if implemented and followed during the next five years, will solve that problem. The past 5 years have seen a broad and general movement toward the assumption of and reliance on networked systems in all of the large new initiatives for DOE science. It is clear that the success of science depends increasingly on the ability of scientists to move large amounts of data, access computing and data resources, and collaborate in real time from multiple remote locations. It is also abundantly clear that business-as-usual in the network and information services that underpin the scientific collaborations will fall woefully short of what is needed. New capabilities such as computational and data grids, high-speed wireless networking, super-high-speed metro-scale networks, and cheap gigabit Ethernet have arrived in turn and have been enthusiastically incorporated into the arsenal of science, each permitting substantial new collaborative abilities and efficiencies. However, sophisticated structures and services using basic network connections can be used effectively only if the network infrastructure itself provides the necessary environment. Increasingly, the network must become a collaborative information exchange, with a core of higher-level services supported by network providers in addition to basic bandwidth and connectivity.

  3. Design A Personal Innovation Plan: 3 Step Roadmap

    OpenAIRE

    Matrix, Sidneyeve

    2014-01-01

    How to be more innovative? Some advice from the experts on how to design your personal innovation roadmap -- in three steps. Slides from a keynote presentation prepared for the Queen's School of Business Innovation Summit.

  4. Grafting of Styrene/ Methacrylic Acid onto a Commercial Poly (tetrafluoroethylene) Film for a Proton Exchange Membrane Fuel Cell

    International Nuclear Information System (INIS)

    El-Toony, M.M.

    2017-01-01

    Gamma irradiation has an important role in grafting of styrene and methacrylic acid with different ratios onto commercial poly (tetrafluoroe thylene) films containing 0.5% silica nanoparticles. It was found that from the grafting process of this system as irradiation dose; 40 kGy,comonomer composition Sty/ MAA (70/30%). The prepared membranes were sulfonated and phosphonated prior to be characterized. The synthesized graft copolymer was investigated using thermogravimetric analysis, scanning electron microscopy and X-ray diffraction. The membranes were examined with proton exchange membrane fuel cell (PEMFC) applicability using water uptake, ion exchange capacity, membrane thickness and tensile strength. Proton conductivity was evaluated, and free volume sizes were measured using positron annihilation life time spectroscopy (PALS). The membranes of highest grafting yield (46%) have a better fuel cell performance and are more durable (up to 450 hours) than commercial compressed Nafion 115

  5. Research and development of Proton-Exchange-Membrane (PEM) fuel cell system for transportation applications. Fuel cell infrastructure and commercialization study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    This paper has been prepared in partial fulfillment of a subcontract from the Allison Division of General Motors under the terms of Allison`s contract with the U.S. Department of Energy (DE-AC02-90CH10435). The objective of this task (The Fuel Cell Infrastructure and Commercialization Study) is to describe and prepare preliminary evaluations of the processes which will be required to develop fuel cell engines for commercial and private vehicles. This report summarizes the work undertaken on this study. It addresses the availability of the infrastructure (services, energy supplies) and the benefits of creating public/private alliances to accelerate their commercialization. The Allison prime contract includes other tasks related to the research and development of advanced solid polymer fuel cell engines and preparation of a demonstration automotive vehicle. The commercialization process starts when there is sufficient understanding of a fuel cell engine`s technology and markets to initiate preparation of a business plan. The business plan will identify each major step in the design of fuel cell (or electrochemical) engines, evaluation of the markets, acquisition of manufacturing facilities, and the technical and financial resources which will be required. The process will end when one or more companies have successfully developed and produced fuel cell engines at a profit. This study addressed the status of the information which will be required to prepare business plans, develop the economic and market acceptance data, and to identify the mobility, energy and environment benefits of electrochemical or fuel cell engines. It provides the reader with information on the status of fuel cell or electrochemical engine development and their relative advantages over competitive propulsion systems. Recommendations and descriptions of additional technical and business evaluations that are to be developed in more detail in Phase II, are included.

  6. The World Heart Federation Roadmap for Nonvalvular Atrial Fibrillation.

    OpenAIRE

    Murphy, A; Banerjee, A; Breithardt, G; Camm, AJ; Commerford, P; Freedman, B; Gonzalez-Hermosillo, JA; Halperin, JL; Lau, C-P; Perel, P; Xavier, D; Wood, D; Jouven, X; Morillo, CA

    2017-01-01

    BACKGROUND: The World Heart Federation has undertaken an initiative to develop a series of Roadmaps to promote development of national policies and health systems approaches, and to identify potential roadblocks on the road to effective prevention, detection, and management of cardiovascular disease in low-and middle-income countries (LMICs) and develop strategies for overcoming these. This Roadmap focuses on atrial fibrillation (AF). AF is the most common, clinically significant arrhythmia a...

  7. The Word Heart Federation Roadmap for Nonvalvular Atrial Fibrillation

    OpenAIRE

    Murphy, A.; Banerjee, A.; Breithardt, G.; Camm, A. J.; Commerford, P.; Freedman, B.; Gonzalez-Hermosillo, J. A.; Halperin, J. L.; Lau, C. P.; Perel, P.; Xavier, D.; Wood, D.; Jouven, X.; Morillo, C. A.

    2017-01-01

    BACKGROUND: The World Heart Federation has undertaken an initiative to develop a series of Roadmaps to promote development of national policies and health systems approaches, and to identify potential roadblocks on the road to effective prevention, detection, and management of cardiovascular disease in low-and middle-income countries (LMICs) and develop strategies for overcoming these. This Roadmap focuses on atrial fibrillation (AF). AF is the most common, clinically significant arrhythmia a...

  8. Strategic Green Energy Roadmap 2011 for South Korea

    International Nuclear Information System (INIS)

    Wijlhuizen, P.

    2011-01-01

    The South Korean energy system depends for 97% on import. The remaining three percent of the energy need is covered by hydropower, solar panels and wind turbines. Korea is looking for alternatives, both for import and for fossil fuels. In 2008, Korea developed its 'Low carbon, green growth' policy, followed by the first 'Strategic green energy roadmap' one year later. Mid-2011 the Ministry of Knowledge Economy published an updated roadmap. [nl

  9. The Parkinson Transcriptome Project: Roadmap to Personalized Care

    Science.gov (United States)

    2015-08-01

    AWARD NUMBER: W81XWH-13-0115 TITLE: The Parkinson Transcriptome Project: Roadmap to Personalized Care PRINCIPAL INVESTIGATOR: Clemens R...5a. CONTRACT NUMBER The Parkinson Transcriptome Project: Roadmap to Personalized Care 5b. GRANT NUMBER W81XWH-13-1-0115 5c. PROGRAM ELEMENT NUMBER 6...Factor = 10) 5. Motor impulsivity in Parkinson disease: Associations with COMT and DRD2 polymorphisms. Ziegler DA, Ashourian P, Wonderlick JS

  10. Measurement of expansin activity and plant cell wall creep by using a commercial texture analyzer

    Directory of Open Access Journals (Sweden)

    Mauro A. Perini

    2017-03-01

    Conclusions: The possibility of measuring expansin activity following this adapted protocol with a commercial texture meter could contribute to ease and increase the analysis of expansin in different systems, leading to a better understanding of the properties of these proteins under different experimental conditions.

  11. In-depth evaluation of commercially available human vascular smooth muscle cells phenotype: Implications for vascular tissue engineering

    Energy Technology Data Exchange (ETDEWEB)

    Timraz, Sara B.H., E-mail: sara.timraz@kustar.ac.ae [Department of Biomedical Engineering, Khalifa University, PO Box 127788, Abu Dhabi (United Arab Emirates); Farhat, Ilyas A.H., E-mail: ilyas.farhat@outlook.com [Department of Applied Mathematics and Sciences, Khalifa University, PO Box 127788, Abu Dhabi (United Arab Emirates); Alhussein, Ghada, E-mail: ghada.alhussein@kustar.ac.ae [Department of Biomedical Engineering, Khalifa University, PO Box 127788, Abu Dhabi (United Arab Emirates); Christoforou, Nicolas, E-mail: nicolas.christoforou@kustar.ac.ae [Department of Biomedical Engineering, Khalifa University, PO Box 127788, Abu Dhabi (United Arab Emirates); Department of Biomedical Engineering, Duke University, Durham, NC 27708 (United States); Teo, Jeremy C.M., E-mail: jeremy.teo@kustar.ac.ae [Department of Biomedical Engineering, Khalifa University, PO Box 127788, Abu Dhabi (United Arab Emirates)

    2016-05-01

    In vitro research on vascular tissue engineering has extensively used isolated primary human or animal smooth muscle cells (SMC). Research programs that lack such facilities tend towards commercially available primary cells sources. Here, we aim to evaluate the capacity of commercially available human SMC to maintain their contractile phenotype, and determine if dedifferentiation towards the synthetic phenotype occurs in response to conventional cell culture and passaging without any external biochemical or mechanical stimuli. Lower passage SMC adopted a contractile phenotype marked by a relatively slower proliferation rate, higher expression of proteins of the contractile apparatus and smoothelin, elongated morphology, and reduced deposition of collagen types I and III. As the passage number increased, migratory capacity was enhanced, average cell speed, total distance and net distance travelled increased up to passage 8. Through the various assays, corroborative evidence pinpoints SMC at passage 7 as the transition point between the contractile and synthetic phenotypes, while passage 8 distinctly and consistently exhibited characteristics of synthetic phenotype. This knowledge is particularly useful in selecting SMC of appropriate passage number for the target vascular tissue engineering application, for example, a homeostatic vascular graft for blood vessel replacement versus recreating atherosclerotic blood vessel model in vitro. - Highlights: • Ability of human smooth muscle cells to alter phenotype in culture is evaluated. • Examined the effect of passaging human smooth muscle cells on phenotype. • Phenotype is assessed based on morphology, proliferation, markers, and migration. • Multi-resolution assessment methodology, single-cell and cell-population. • Lower and higher passages than P7 adopted a contractile and synthetic phenotype respectively.

  12. Separations and Actinide Science -- 2005 Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    2005-09-01

    The Separations and Actinide Science Roadmap presents a vision to establish a separations and actinide science research (SASR) base composed of people, facilities, and collaborations and provides new and innovative nuclear fuel cycle solutions to nuclear technology issues that preclude nuclear proliferation. This enabling science base will play a key role in ensuring that Idaho National Laboratory (INL) achieves its long-term vision of revitalizing nuclear energy by providing needed technologies to ensure our nation's energy sustainability and security. To that end, this roadmap suggests a 10-year journey to build a strong SASR technical capability with a clear mission to support nuclear technology development. If nuclear technology is to be used to satisfy the expected growth in U.S. electrical energy demand, the once-through fuel cycle currently in use should be reconsidered. Although the once-through fuel cycle is cost-effective and uranium is inexpensive, a once-through fuel cycle requires long-term disposal to protect the environment and public from long-lived radioactive species. The lack of a current disposal option (i.e., a licensed repository) has resulted in accumulation of more than 50,000 metric tons of spent nuclear fuel. The process required to transition the current once-through fuel cycle to full-recycle will require considerable time and significant technical advancement. INL's extensive expertise in aqueous separations will be used to develop advanced separations processes. Computational chemistry will be expanded to support development of future processing options. In the intermediate stage of this transition, reprocessing options will be deployed, waste forms with higher loading densities and greater stability will be developed, and transmutation of long-lived fission products will be explored. SASR will support these activities using its actinide science and aqueous separations expertise. In the final stage, full recycle will be

  13. Roadmapping - A Tool for Strategic Planning and Leveraging R and D completed by other Agencies

    International Nuclear Information System (INIS)

    Collins, J. W.

    2002-01-01

    The Department of Energy (DOE) is responsible for management of the environmental legacy of the nation's nuclear weapons and research program. This is the largest, most complex environmental cleanup program in the world. The issues and problems encountered in this program create the need to develop many scientific and technological solutions. To be effective, the process used to create these solutions must be well coordinated through DOE's Environmental Management program, the rest of DOE, and other Federal agencies. Roadmapping is one strategic planning tool to provide the needed coordination. Past roadmapping accomplishments include: (1) Issuance of the Draft EM Roadmapping Guidance; (2) Issuance of the EM R and D Program Plan and Strategic Plan which established the direction for Roadmapping; (3) Issuance of the OST Management Plan which calls out Roadmapping as a key tool in EM Research and Development (R and D) Strategic Planning; (4) Completion of or progress on key EM Roadmaps, i.e., Savannah River High Level Waste (HLW) Salt Dispositioning Roadmaps, Hanford Groundwater/Vadose Zone Roadmap, Robotics and Intelligent Machines Critical Technology Roadmap, Complex-Wide Vadose Zone Roadmap, Long-Term Stewardship Preliminary Roadmap, Hydrogen Gas Generation R and D Plan (Roadmap), Idaho National Engineering and Environmental Laboratory (INEEL) Sodium Bearing Waste Dispositioning Roadmap, INEEL Voluntary Consent Order Tanks Characterization Roadmap, INEEL Vadose Zone/Groundwater Roadmap, Calcine Treatment Alternatives Roadmap. These efforts represent a great start; however, there is more to be accomplished in using Roadmapping as a tool for planning strategic initiatives and in coordinating the R and D performed by multiple federal agencies

  14. Space Heaters, Computers, Cell Phone Chargers: How Plugged In AreCommercial Buildings?

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, Marla; Webber, Carrie; Brown, Richard; Busch, John; Pinckard, Margaret; Roberson, Judy

    2007-02-28

    Evidenceof electric plug loads in commercial buildings isvisible everyday: space heaters, portable fans, and the IT technician'stwo monitors connected to one PC. The Energy Information Administrationestimates that office and miscellaneous equipment together will consume2.18 quads in 2006, nearly 50 percent of U.S. commercial electricity use.Although the importance of commercial plug loads is documented, its verynature (diverse product types, products not installed when buildinginitially constructed, and products often hidden in closets) makes itdifficult to accurately count and categorize the end use.We auditedsixteen buildings in three cities (San Francisco, Atlanta, Pittsburgh)including office, medical and education building types. We inventoriedthe number and types of office and miscellaneous electric equipment aswell as estimated total energy consumption due to these product types. Intotal, we audited approximately 4,000 units of office equipment and 6,000units of miscellaneous equipment and covered a diverse range of productsranging from electric pencil sharpeners with a unit energy consumption(UEC) of 1 kWh/yr to a kiln with a UEC of 7,000 kWh/yr. Our paperpresents a summary of the density and type of plug load equipment foundas well as the estimated total energy consumption of the equipment.Additionally, we present equipment trends observed and provide insightsto how policy makers can target energy efficiency for this growing enduse.

  15. SQUIDs in biomagnetism: a roadmap towards improved healthcare

    Science.gov (United States)

    Körber, Rainer; Storm, Jan-Hendrik; Seton, Hugh; Mäkelä, Jyrki P.; Paetau, Ritva; Parkkonen, Lauri; Pfeiffer, Christoph; Riaz, Bushra; Schneiderman, Justin F.; Dong, Hui; Hwang, Seong-min; You, Lixing; Inglis, Ben; Clarke, John; Espy, Michelle A.; Ilmoniemi, Risto J.; Magnelind, Per E.; Matlashov, Andrei N.; Nieminen, Jaakko O.; Volegov, Petr L.; Zevenhoven, Koos C. J.; Höfner, Nora; Burghoff, Martin; Enpuku, Keiji; Yang, S. Y.; Chieh, Jen-Jei; Knuutila, Jukka; Laine, Petteri; Nenonen, Jukka

    2016-11-01

    to its corresponding antigen, if it is present. Any resulting changes in the properties of the nanoparticles are detected with a SQUID. For liquid-phase detection, there are three basic methods: AC susceptibility, magnetic relaxation and remanence measurement. These methods, which have been successfully implemented for both in vivo and ex vivo applications, are highly sensitive and, although further development is required, it appears highly likely that at least some of them will be commercialized. Chapter 8 concludes the roadmap with an assessment of the commercial market for MEG systems. Despite the huge advances that have been realized since MEG was first introduced, the number of commercial systems deployed around the world remains small, around 250 units employing about 50 000 SQUIDs. The slow adoption of this technology is undoubtedly in part due to the high cost, not least because of the need to surround the entire system in an expensive magnetically shielded room. Nonetheless, the recent introduction of automatically refilling liquid-helium systems, the ongoing reduction in sensor noise, the potential availability of high-T c SQUID systems, the availability of new and better software and the combination of MEG with ULF MRI all have the potential to increase the market size in the not-so-distant future. In particular, there is a great and growing need for better noninvasive technologies to measure brain function. There are hundreds of millions of people in the world who suffer from brain disorders such as epilepsy, stroke, dementia or depression. The enormous cost to society of these diseases can be reduced by earlier and more accurate detection and diagnosis. Once the challenges outlined in this roadmap have been met and the outstanding problems have been solved, the potential demand for SQUID-based health technology can be expected to increase by ten- if not hundred-fold.

  16. NASA's Microgravity Fluid Physics Strategic Research Roadmap

    Science.gov (United States)

    Motil, Brian J.; Singh, Bhim S.

    2004-01-01

    The Microgravity Fluid Physics Program at NASA has developed a substantial investigator base engaging a broad crosssection of the U.S. scientific community. As a result, it enjoys a rich history of many significant scientific achievements. The research supported by the program has produced many important findings that have been published in prestigious journals such as Science, Nature, Journal of Fluid Mechanics, Physics of Fluids, and many others. The focus of the program so far has primarily been on fundamental scientific studies. However, a recent shift in emphasis at NASA to develop advanced technologies to enable future exploration of space has provided motivation to add a strategic research component to the program. This has set into motion a year of intense planning within NASA including three workshops to solicit inputs from the external scientific community. The planning activities and the workshops have resulted in a prioritized list of strategic research issues along with a corresponding detailed roadmap specific to fluid physics. The results of these activities were provided to NASA s Office of Biological and Physical Research (OBPR) to support the development of the Enterprise Strategy document. This paper summarizes these results while showing how the planned research supports NASA s overall vision through OBPR s organizing questions.

  17. AFCI Safeguards Enhancement Study: Technology Development Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Leon E.; Dougan, A.; Tobin, Stephen; Cipiti, B.; Ehinger, Michael H.; Bakel, A. J.; Bean, Robert; Grate, Jay W.; Santi, P.; Bryan, Steven; Kinlaw, M. T.; Schwantes, Jon M.; Burr, Tom; Lehn, Scott A.; Tolk, K.; Chichester, David; Menlove, H.; Vo, D.; Duckworth, Douglas C.; Merkle, P.; Wang, T. F.; Duran, F.; Nakae, L.; Warren, Glen A.; Friedrich, S.; Rabin, M.

    2008-12-31

    The Advanced Fuel Cycle Initiative (AFCI) Safeguards Campaign aims to develop safeguards technologies and processes that will significantly reduce the risk of proliferation in the U.S. nuclear fuel cycle of tomorrow. The Safeguards Enhancement Study was chartered with identifying promising research and development (R&D) directions over timescales both near-term and long-term, and under safeguards oversight both domestic and international. This technology development roadmap documents recognized gaps and needs in the safeguarding of nuclear fuel cycles, and outlines corresponding performance targets for each of those needs. Drawing on the collective expertise of technologists and user-representatives, a list of over 30 technologies that have the potential to meet those needs was developed, along with brief summaries of each candidate technology. Each summary describes the potential impact of that technology, key research questions to be addressed, and prospective development milestones that could lead to a definitive viability or performance assessment. Important programmatic linkages between U.S. agencies and offices are also described, reflecting the emergence of several safeguards R&D programs in the U.S. and the reinvigoration of nuclear fuel cycles across the globe.

  18. Road-map for 2. generation biofuels

    International Nuclear Information System (INIS)

    2009-01-01

    This document presents road-map issues concerning the requirements for biofuels of second generation, and defines the priorities addressed by a demonstrator program. It recalls the context created by the challenges of climate change and the excessive dependence on fossil fuels, and the objectives defined by the European Union in terms of biofuel share in the global consumption. Then, it describes the candidate technologies for the production of this second generation of biofuels, those based on thermo-chemical processes (mainly the pyrolysis-gasification of biomass), and those based on biochemical processes (enzymatic hydrolysis and fermentation of biomass). It highlights the technological challenges for these processes, and describes the various objectives of research projects supported by a 'demonstrator fund'. It discusses the necessity to develop demonstrators, and mentions some current projects of private companies, competitiveness clusters, and public research institutions. An agenda is defined from 2009 to 2020 which encompasses the research, demonstration and operation phases. An appendix provides brief presentations of thermo-chemical or biological demonstrators currently under operation or under construction in foreign countries (Germany, Finland, United States of America, Sweden, Spain, Canada, Japan, and Denmark)

  19. Technology Roadmap: Fuel Economy of Road Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    This roadmap explores the potential improvement of existing technologies to enhance the average fuel economy of motorised vehicles; the roadmap’s vision is to achieve a 30% to 50% reduction in fuel use per kilometre from new road vehicles including 2-wheelers, LDV s and HDV s) around the world in 2030, and from the stock of all vehicles on the road by 2050. This achievement would contribute to significant reductions in GHG emissions and oil use, compared to a baseline projection. Different motorised modes are treated separately, with a focus on LDV s, HDV s and powered two-wheelers. A section on in-use fuel economy also addresses technical and nontechnical parameters that could allow fuel economy to drastically improve over the next decades. Technology cost analysis and payback time show that significant progress can be made with low or negative cost for fuel-efficient vehicles over their lifetime use. Even though the latest data analysed by the IEA for fuel economy between 2005 and 2008 showed that a gap exists in achieving the roadmap’s vision, cutting the average fuel economy of road motorised vehicles by 30% to 50% by 2030 is achievable, and the policies and technologies that could help meet this challenge are already deployed in many places around the world.

  20. Short Term Culture of Human Mesenchymal Stem Cells with Commercial Osteoconductive Carriers Provides Unique Insights into Biocompatibility

    Directory of Open Access Journals (Sweden)

    Matthew B. Murphy

    2013-08-01

    Full Text Available For spinal fusions and the treatment of non-union fractures, biological substrates, scaffolds, or carriers often are applied as a graft to support regeneration of bone. The selection of an appropriate material critically influences cellular function and, ultimately, patient outcomes. Human bone marrow mesenchymal stem cells (BMSCs are regarded as a critical component of bone healing. However, the interactions of BMSCs and commercial bone matrices are poorly reported. BMSCs were cultured with several commercially available bone substrates (allograft, demineralized bone matrix (DBM, collagen, and various forms of calcium phosphates for 48 h to understand their response to graft materials during surgical preparation and the first days following implantation (cell retention, gene expression, pH. At 30 and 60 min, bone chips and inorganic substrates supported significantly more cell retention than other materials, while collagen-containing materials became soluble and lost their structure. At 48 h, cells bound to β-tricalcium phosphate-hydroxyapatite (βTCP-HA and porous hydroxyapatite (HA granules exhibited osteogenic gene expression statistically similar to bone chips. Through 24 h, the DBM strip and βTCP-collagen became mildly acidic (pH 7.1–7.3, while the DBM poloxamer-putties demonstrated acidity (pH 10. The dissolution of DBM and collagen led to a loss of cells, while excessive pH changes potentially diminish cell viability and metabolism. Extracts from DBM-poloxamers induced osteogenic gene expression at 48 h. This study highlights the role that biochemical and structural properties of biomaterials play in cellular function, potentially enhancing or diminishing the efficacy of the overall therapy.

  1. Continuing the International Roadmapping Effort - An Introduction to the Evolution of the ISECG Global Exploration Roadmap

    Science.gov (United States)

    Schlutz, Juergen; Hufenbach, Bernhard; Laurini, Kathy; Spiero, Francois

    2016-07-01

    Future space exploration goals call for sending humans and robots beyond low Earth orbit and establishing sustained access to destinations such as the Moon, asteroids and Mars. Space agencies participating in the International Space Exploration Coordination Group (ISECG) are discussing an international approach for achieving these goals, documented in ISECG's Global Exploration Roadmap (GER). The GER reference scenario reflects a step-wise evolution of critical capabilities from ISS to missions in the lunar vicinity in preparation for the journey of humans to Mars. As ISECG agencies advance their individual planning, they also advance the mission themes and reference architecture of the GER to consolidate common goals, near-term mission scenarios and initial opportunities for collaboration. In this context, particular focus has been given to the Better understanding and further refinement of cislunar infrastructure and potential lunar transportation architecture Interaction with international science communities to identify and articulate the scientific opportunities of the near-term exploration mission themes Coordination and consolidation of interest in lunar polar volatiles prospecting and potential for in-situ resource utilisation Identification and articulation of the benefits from exploration and the technology transfer activities The paper discusses the ongoing roadmapping activity of the ISECG agencies. It provides an insight into the status of the above activities and an outlook towards the evolution of the GER that is currently foreseen in the 2017 timeframe.

  2. Analysis of single event transient pulse-width in 65 nm commercial radiation-hardened logic cell

    Science.gov (United States)

    Li, Haisong; Wu, Longsheng; Yang, Bo; Jiang, Yihu

    2017-08-01

    With the critical charge reduced to generate a single event effect (SEE) and high working frequency for a nanometer integrated circuit, the single event effect (SET) becomes increasingly serious for high performance SOC and DSP chips. To analyze the radiation-hardened method of SET for the nanometer integrated circuit, the n+ guard ring and p+ guard ring have been adopted in the layout for a 65 nm commercial radiation-hardened standard cell library. The weakest driving capacity inverter cell was used to evaluate the single event transient (SET) pulse-width distribution. We employed a dual-lane measurement circuit to get more accurate SET’s pulse-width. Six kinds of ions, which provide LETs of 12.5, 22.5, 32.5, 42, 63, and 79.5 {MeV}\\cdot {{cm}}2/{mg}, respectively, have been utilized to irradiate the SET test circuit in the Beijing Tandem Accelerator Nuclear Physics National Laboratory. The testing results reveal that the pulse-width of most SETs is shorter than 400 ps in the range of LETeff from 12.5 {MeV}\\cdot {{cm}}2/{mg} to 79.5 {MeV}\\cdot {{cm}}2/{mg} and the pulse-width presents saturation tendency when the effective linear energy transfer (LETeff) value is larger than 40 {MeV}\\cdot {{cm}}2/{mg}. The test results also show that the hardened commercial standard cell’s pulse-width concentrates on 33 to 264 ps, which decreases by 40% compared to the pulse-width of the 65 nm commercial unhardened standard cell.

  3. Uranium Mill Tailings Remedial Action fiscal year 1992 roadmap

    International Nuclear Information System (INIS)

    1993-02-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project is funded and managed as two separate projects: Surface remediation (UMTRA-S) and Groundwater compliance (UMTRA-G). Surface remediation is a Major System Acquisition and has been completed at 10 sites, 7 sites are under construction, and 7 sites are in the planning stage. The planning stages of the UMTRA-G Project, a major project, began in April 1991. A programmatic environmental impact statement (PEIS) has been started. Site characterization work and baseline risk assessment will begin FY 1993. Thus, the UMTRA-S Project is a mature and ongoing program with the roles of various organizations well defined, while the UMTRA-G Project is still being formulated and the interfaces between the DOE, states and tribes, and the EPA are being established. The Office of Environmental Restoration and Waste Management (EM) directed that all projects under its authority develop roadmaps for their activities. The UMTRA Project Roadmap was developed by the UMTRA Project Office with input from the TAC, RAC, the GJPO, and assistance from SAIC. A single roadmap has been prepared for both the UMTRA-S and UMTRA-G Projects. This was deemed appropriate due to the close relationship between the projects and to the fact that the same Government and contractor personnel are preparing the roadmaps. Roadmap development is a planning process that focuses on issue identification, root-cause analysis, and issues resolution. The methodology is divided into three phases: assessment, analysis, and issues resolution

  4. The 2017 Plasma Roadmap: Low temperature plasma science and technology

    Science.gov (United States)

    Adamovich, I.; Baalrud, S. D.; Bogaerts, A.; Bruggeman, P. J.; Cappelli, M.; Colombo, V.; Czarnetzki, U.; Ebert, U.; Eden, J. G.; Favia, P.; Graves, D. B.; Hamaguchi, S.; Hieftje, G.; Hori, M.; Kaganovich, I. D.; Kortshagen, U.; Kushner, M. J.; Mason, N. J.; Mazouffre, S.; Mededovic Thagard, S.; Metelmann, H.-R.; Mizuno, A.; Moreau, E.; Murphy, A. B.; Niemira, B. A.; Oehrlein, G. S.; Petrovic, Z. Lj; Pitchford, L. C.; Pu, Y.-K.; Rauf, S.; Sakai, O.; Samukawa, S.; Starikovskaia, S.; Tennyson, J.; Terashima, K.; Turner, M. M.; van de Sanden, M. C. M.; Vardelle, A.

    2017-08-01

    Journal of Physics D: Applied Physics published the first Plasma Roadmap in 2012 consisting of the individual perspectives of 16 leading experts in the various sub-fields of low temperature plasma science and technology. The 2017 Plasma Roadmap is the first update of a planned series of periodic updates of the Plasma Roadmap. The continuously growing interdisciplinary nature of the low temperature plasma field and its equally broad range of applications are making it increasingly difficult to identify major challenges that encompass all of the many sub-fields and applications. This intellectual diversity is ultimately a strength of the field. The current state of the art for the 19 sub-fields addressed in this roadmap demonstrates the enviable track record of the low temperature plasma field in the development of plasmas as an enabling technology for a vast range of technologies that underpin our modern society. At the same time, the many important scientific and technological challenges shared in this roadmap show that the path forward is not only scientifically rich but has the potential to make wide and far reaching contributions to many societal challenges.

  5. A roadmap for the development and market introduction of PVT technology

    Energy Technology Data Exchange (ETDEWEB)

    Zondag, H.A.; Van Helden, W.G.J.; Bakker, M.; Elswijk, M.J. [ECN Renewable Energy in the Built Environment DEGO, Petten (Netherlands)

    2005-11-15

    In PVT technology, heat is extracted from PV cells. In this way, a device is made that produces both electricity and heat. In the EU funded coordination action PV-Catapult, workshops on PVT were organised at the PVSEC 2004 Conference in Paris and the Eurosun 2004 conference in Freiburg, to obtain active participation of the PV and solar thermal communities. Currently, the results of the workshops are used in the drafting of a roadmap for the large scale introduction of PVT technology on the market. First results will be presented here.

  6. PVT roadmap. A European guide for the development and market introduction of PVT technology

    International Nuclear Information System (INIS)

    Zondag, H.A.; Van Helden, W.G.J.; Bakker, M.; Affolter, P.; Eisenmann, W.; Fechner, H.; Rommel, M.; Schaap, A.; Soerensen, H.; Tripanagnostopoulos, Y.

    2005-11-01

    In PVT technology, heat is extracted from PV cells. In this way, a device is made that produces both electricity and heat. In the EU-funded co-ordination action PV-Catapult, workshops on PVT were organised at the PVSEC 2004 Conference in Paris and the Eurosun 2004 conference in Freiburg, to obtain active participation of the PV and solar thermal communities. Currently, the results of the workshops are used in the drafting of a roadmap for the large-scale introduction of PVT technology on the market. First results will be presented here

  7. PVT roadmap. A European guide for the development and market introduction of PVT technology

    Energy Technology Data Exchange (ETDEWEB)

    Zondag, H.A.; Van Helden, W.G.J.; Bakker, M. [ECN Renewable Energy in the Built Environment DEGO, Petten (Netherlands); Affolter, P. [Solstis, Lausanne (Switzerland); Eisenmann, W. [Institut fuer Solarenergieforschung ISFH, Emmerthal (Germany); Fechner, H. [Arsenal Research, Vienna (Austria); Rommel, M. [Fraunhofer ISE, Freiburg (Germany); Schaap, A. [Ecofys, Utrecht (Netherlands); Soerensen, H. [Esbensen, Copenhagen (Denmark); Tripanagnostopoulos, Y. [University of Patras, Patras (Greece)

    2005-11-15

    In PVT technology, heat is extracted from PV cells. In this way, a device is made that produces both electricity and heat. In the EU-funded co-ordination action PV-Catapult, workshops on PVT were organised at the PVSEC 2004 Conference in Paris and the Eurosun 2004 conference in Freiburg, to obtain active participation of the PV and solar thermal communities. Currently, the results of the workshops are used in the drafting of a roadmap for the large-scale introduction of PVT technology on the market. First results will be presented here.

  8. A roadmap for the development and market introduction of PVT technology

    International Nuclear Information System (INIS)

    Zondag, H.A.; Van Helden, W.G.J.; Bakker, M.; Elswijk, M.J.

    2005-11-01

    In PVT technology, heat is extracted from PV cells. In this way, a device is made that produces both electricity and heat. In the EU funded coordination action PV-Catapult, workshops on PVT were organised at the PVSEC 2004 Conference in Paris and the Eurosun 2004 conference in Freiburg, to obtain active participation of the PV and solar thermal communities. Currently, the results of the workshops are used in the drafting of a roadmap for the large scale introduction of PVT technology on the market. First results will be presented here

  9. A roadmap for photovoltaic-thermal panels. Combination of techniques offers many advantages

    International Nuclear Information System (INIS)

    Zondag, H.A.; Van Helden, W.G.J.; Bakker, M.

    2006-01-01

    In PVT technology, heat is extracted from PV cells. In this way, a device is made that produces both electricity and heat. In the EU funded coordination action PV-Catapult, workshops on PVT were organised at the PVSEC 2004 Conference in Paris and the Eurosun 2004 conference in Freiburg, to obtain active participation of the PV and solar thermal communities. Currently, the results of the workshops are used in the drafting of a roadmap for the large scale introduction of PVT technology on the market. First results will be presented here [nl

  10. Program of scientific investigations and development of solid-oxide fuel cells (SOFC) in VNIITF. Proposals on scientific and technical collaboration and SOFC commercialization

    Energy Technology Data Exchange (ETDEWEB)

    Kleschev, Yu.N.; Chukharev, V.F.

    1996-04-01

    This paper describes proposals on scientific and technical collaborations pertaining to solid oxide fuel cell commercialization. Topics included for discussion are: materials research and manufacture; market estimation and cost; directions of collaboration; and project of proposals on joint enterprise creation.

  11. A novel mechanistic modeling framework for analysis of electrode balancing and degradation modes in commercial lithium-ion cells

    Science.gov (United States)

    Schindler, Stefan; Danzer, Michael A.

    2017-03-01

    Aiming at a long-term stable and safe operation of rechargeable lithium-ion cells, elementary design aspects and degradation phenomena have to be considered depending on the specific application. Among the degrees of freedom in cell design, electrode balancing is of particular interest and has a distinct effect on useable capacity and voltage range. Concerning intrinsic degradation modes, understanding the underlying electrochemical processes and tracing the overall degradation history are the most crucial tasks. In this study, a model-based, minimal parameter framework for combined elucidation of electrode balancing and degradation pathways in commercial lithium-ion cells is introduced. The framework rests upon the simulation of full cell voltage profiles from the superposition of equivalent, artificially degraded half-cell profiles and allows to separate aging contributions from loss of available lithium and active materials in both electrodes. A physically meaningful coupling between thermodynamic and kinetic degradation modes based on the correlation between altered impedance features and loss of available lithium as well as loss of active material is proposed and validated by a low temperature degradation profile examined in one of our recent publications. The coupled framework is able to determine the electrode balancing within an error range of < 1% and the projected cell degradation is qualitatively and quantitatively in line with experimental observations.

  12. Superconductivity and the environment: a Roadmap

    Science.gov (United States)

    Nishijima, Shigehiro; Eckroad, Steven; Marian, Adela; Choi, Kyeongdal; Kim, Woo Seok; Terai, Motoaki; Deng, Zigang; Zheng, Jun; Wang, Jiasu; Umemoto, Katsuya; Du, Jia; Febvre, Pascal; Keenan, Shane; Mukhanov, Oleg; Cooley, Lance D.; Foley, Cathy P.; Hassenzahl, William V.; Izumi, Mitsuru

    2013-11-01

    There is universal agreement between the United Nations and governments from the richest to the poorest nations that humanity faces unprecedented global challenges relating to sustainable energy, clean water, low-emission transportation, coping with climate change and natural disasters, and reclaiming use of land. We have invited researchers from a range of eclectic research areas to provide a Roadmap of how superconducting technologies could address these major challenges confronting humanity. Superconductivity has, over the century since its discovery by Kamerlingh Onnes in 1911, promised to provide solutions to many challenges. So far, most superconducting technologies are esoteric systems that are used in laboratories and hospitals. Large science projects have long appreciated the ability of superconductivity to efficiently create high magnetic fields that are otherwise very costly to achieve with ordinary materials. The most successful applications outside of large science are high-field magnets for magnetic resonance imaging, laboratory magnetometers for mineral and materials characterization, filters for mobile communications, and magnetoencephalography for understanding the human brain. The stage is now set for superconductivity to make more general contributions. Humanity uses practically unthinkable amounts of energy to drive our modern way of life. Overall, global power usage has been predicted to almost double from 16.5 to 30 TW in the next four decades (2011 Equinox Summit: Energy 2030 http://wgsi.org/publications-resources). The economy with which electrons carry energy compels the continued quest for efficient superconducting power generation, energy storage, and power transmission. The growing global population requires new arable land and treatment of water, especially in remote areas, and superconductivity offers unique solutions to these problems. Exquisite detectors give warning of changes that are otherwise invisible. Prediction of climate and

  13. Superconductivity and the environment: a Roadmap

    International Nuclear Information System (INIS)

    Nishijima, Shigehiro; Eckroad, Steven; Marian, Adela; Choi, Kyeongdal; Kim, Woo Seok; Terai, Motoaki; Deng, Zigang; Zheng, Jun; Wang, Jiasu; Umemoto, Katsuya; Du, Jia; Keenan, Shane; Foley, Cathy P; Febvre, Pascal; Mukhanov, Oleg; Cooley, Lance D; Hassenzahl, William V; Izumi, Mitsuru

    2013-01-01

    There is universal agreement between the United Nations and governments from the richest to the poorest nations that humanity faces unprecedented global challenges relating to sustainable energy, clean water, low-emission transportation, coping with climate change and natural disasters, and reclaiming use of land. We have invited researchers from a range of eclectic research areas to provide a Roadmap of how superconducting technologies could address these major challenges confronting humanity. Superconductivity has, over the century since its discovery by Kamerlingh Onnes in 1911, promised to provide solutions to many challenges. So far, most superconducting technologies are esoteric systems that are used in laboratories and hospitals. Large science projects have long appreciated the ability of superconductivity to efficiently create high magnetic fields that are otherwise very costly to achieve with ordinary materials. The most successful applications outside of large science are high-field magnets for magnetic resonance imaging, laboratory magnetometers for mineral and materials characterization, filters for mobile communications, and magnetoencephalography for understanding the human brain. The stage is now set for superconductivity to make more general contributions. Humanity uses practically unthinkable amounts of energy to drive our modern way of life. Overall, global power usage has been predicted to almost double from 16.5 to 30 TW in the next four decades (2011 Equinox Summit: Energy 2030 http://wgsi.org/publications-resources). The economy with which electrons carry energy compels the continued quest for efficient superconducting power generation, energy storage, and power transmission. The growing global population requires new arable land and treatment of water, especially in remote areas, and superconductivity offers unique solutions to these problems. Exquisite detectors give warning of changes that are otherwise invisible. Prediction of climate and

  14. Commercial Laboratory Testing of Excision Repair Cross-Complementation Group 1 Expression in Non-Small Cell Lung Cancer

    Science.gov (United States)

    Farhadfar, Nosha; Sivapiragasam, Abirami; Geller, Matthew; Islam, Shahidul; Selbs, Elena

    2014-01-01

    Introduction. Excision repair cross-complementation group 1 (ERCC1) expression by non-small cell lung cancer (NSCLC) has been reported to predict resistance to platinum-based therapies. On this basis, several commercial laboratories have offered ERCC1 testing to facilitate clinical decision making, but the reliability of such assays has recently been called into question. Methods. First, three large commercial laboratories were queried for their cumulative ERCC1 test results in NSCLC patients to compare their independent rates of ERCC1 expression. Second, identical tumor blocks from individual NSCLC patients underwent round-robin analysis to evaluate interlaboratory concordance for ERCC1 expression. Third, a retrospective review of medical records from NSCLC patients identified those who were both highly responsive and resistant to platinum-based chemotherapies. Tumor blocks from these patients were then used in a gold standard analysis to determine individual laboratory sensitivity and specificity for ERCC1 results. Results. Significant differences were observed in independent laboratory ERRC1 expression rates (Clarient 70% vs. Genzyme 60% vs. Third Laboratory 44%, p marketed laboratory assays achieved a specificity of greater than 50%. Conclusion. The results of commercial laboratory testing for ERCC1 are inconsistent and unreliable. Better validation and postmarketing surveillance should be mandated before tumor biomarker assays are allowed to enter the clinical arena. PMID:24705979

  15. Rapid mitigation of carrier-induced degradation in commercial silicon solar cells

    Science.gov (United States)

    Hallam, Brett J.; Chan, Catherine E.; Chen, Ran; Wang, Sisi; Ji, Jingjia; Mai, Ly; Abbott, Malcolm D.; Payne, David N. R.; Kim, Moonyong; Chen, Daniel; Chong, CheeMun; Wenham, Stuart R.

    2017-08-01

    We report on the progress for the understanding of carrier-induced degradation (CID) in p-type mono and multi-crystalline silicon (mc-Si) solar cells, and methods of mitigation. Defect formation is a key aspect to mitigating CID. Illuminated annealing can be used for both mono and mc-Si solar cells to reduce CID. The latest results of an 8-s UNSW advanced hydrogenation process applied to industrial p-type Czochralski PERC solar cells are shown with average efficiency enhancements of 1.1% absolute from eight different solar cell manufacturers. Results from three new industrial CID mitigation tools are presented, reducing CID to 0.8-1.1% relative, compared to 4.2% relative on control cells. Similar advanced hydrogenation processes can also be applied to multi-crystalline silicon passivated emitter with rear local contact (PERC) cells, however to date, the processes take longer and are less effective. Modifications to the firing processes can also suppress CID in multi-crystalline cells during subsequent illumination. The most stable results are achieved with a multi-stage process consisting of a second firing process at a reduced firing temperature, followed by extended illuminated annealing.

  16. Roadmapping e roadmap tecnológico: uma proposta prática para Instituições Científicas e Tecnológicas

    Directory of Open Access Journals (Sweden)

    Antonio Ramalho de Souza Carvalho

    2018-02-01

    Full Text Available Este artigo objetiva apresentar uma proposta prática de elaboração de Roadmapping e Roadmap tecnológico para Instituições Científicas e Tecnológicas (ICT que possuam um nível incipiente de elaboração desses documentos. O estudo ocorreu em 2016 e apresenta um modelo conceitual seguindo a abordagem Entidade-Relacionamento. O referencial teórico utiliza conceitos de Roadmappings e Roadmaps. Apresenta-se uma proposta de Roadmapping e Roadmap tecnológico para ICT, no qual são definidos os atores responsáveis por introduzir o Roadmapping tecnológico, principais níveis de arquitetura do Roadmap tecnológico, as etapas norteadoras para elaboração do Roadmap tecnológico das ICT, os dez passos norteadores do Roadmapping tecnológico para as ICT, e ao final, a Matriz de arquitetura de Roadmap tecnológico para ICT. Conclui-se que trata de uma ferramenta de acoplamento dos projetos de P&D à Visão tecnológica e que a aplicabilidade do modelo somente será viável para ICT que estejam num nível incipiente de elaboração do Roadmapping tecnológico, uma vez que, o exercício de elaboração de Roadmapping tecnológico é um processo de aprendizagem e de reestruturação de processos já relacionados, onde ICT maduras nesta prática, já possuem processos forjados para suas necessidades.

  17. Food for thought ... A toxicology ontology roadmap.

    Science.gov (United States)

    Hardy, Barry; Apic, Gordana; Carthew, Philip; Clark, Dominic; Cook, David; Dix, Ian; Escher, Sylvia; Hastings, Janna; Heard, David J; Jeliazkova, Nina; Judson, Philip; Matis-Mitchell, Sherri; Mitic, Dragana; Myatt, Glenn; Shah, Imran; Spjuth, Ola; Tcheremenskaia, Olga; Toldo, Luca; Watson, David; White, Andrew; Yang, Chihae

    2012-01-01

    Foreign substances can have a dramatic and unpredictable adverse effect on human health. In the development of new therapeutic agents, it is essential that the potential adverse effects of all candidates be identified as early as possible. The field of predictive toxicology strives to profile the potential for adverse effects of novel chemical substances before they occur, both with traditional in vivo experimental approaches and increasingly through the development of in vitro and computational methods which can supplement and reduce the need for animal testing. To be maximally effective, the field needs access to the largest possible knowledge base of previous toxicology findings, and such results need to be made available in such a fashion so as to be interoperable, comparable, and compatible with standard toolkits. This necessitates the development of open, public, computable, and standardized toxicology vocabularies and ontologies so as to support the applications required by in silico, in vitro, and in vivo toxicology methods and related analysis and reporting activities. Such ontology development will support data management, model building, integrated analysis, validation and reporting, including regulatory reporting and alternative testing submission requirements as required by guidelines such as the REACH legislation, leading to new scientific advances in a mechanistically-based predictive toxicology. Numerous existing ontology and standards initiatives can contribute to the creation of a toxicology ontology supporting the needs of predictive toxicology and risk assessment. Additionally, new ontologies are needed to satisfy practical use cases and scenarios where gaps currently exist. Developing and integrating these resources will require a well-coordinated and sustained effort across numerous stakeholders engaged in a public-private partnership. In this communication, we set out a roadmap for the development of an integrated toxicology ontology

  18. Technology Roadmaps: A guide to development and implementation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    New low-carbon technologies show clear potential for transforming the global energy system, but a key challenge remains: what steps do governments and industry need to take to ensure their development and deployment? Roadmapping, used for decades in technology-intensive industries, is a useful tool to help address complicated issues strategically at the national, regional and global levels. To help turn political statements and analytical work into concrete action, the International Energy Agency (IEA) is developing a series of global roadmaps devoted to low-carbon energy technologies. This guide is aimed at providing countries and companies with the context, information and tools they need to design, manage and implement an effective energy roadmap process.

  19. Physicochemical characteristics and bronchial epithelial cell cytotoxicity of Folpan 80 WG® and Myco 500®, two commercial forms of folpet

    Directory of Open Access Journals (Sweden)

    Baldi Isabelle

    2007-09-01

    Full Text Available Abstract Background Pesticides, in particular folpet, have been found in rural and urban air in France in the past few years. Folpet is a contact fungicide and has been widely used for the past 50 years in vineyards in France. Slightly water-soluble and mostly present as particles in the environment, it has been measured at average concentration of 40.1 μg/m3 during its spraying, 0.16–1.2 μg/m3 in rural air and around 0.01 μg/m3 in urban air, potentially exposing both the workers and the general population. However, no study on its penetration by inhalation and on its respiratory toxicity has been published. The objective of this study was to determine the physicochemical characteristics of folpet particles (morphology, granulometry, stability in its commercial forms under their typical application conditions. Moreover, the cytotoxic effect of these particles and the generation of reactive oxygen species were assessed in vitro on respiratory cells. Results Granulometry of two commercial forms of folpet (Folpan 80WG® and Myco 500® under their typical application conditions showed that the majority of the particles (>75% had a size under 5 μm, and therefore could be inhaled by humans. These particles were relatively stable over time: more than 75% of folpet remained in the particle suspension after 30 days under the typical application conditions. The inhibitory concentration (IC50 on human bronchial epithelial cells (16HBE14o- was found to be between 2.89 and 5.11 μg/cm2 for folpet commercial products after 24 h of exposure. Folpet degradation products and vehicles of Folpan 80 WG® did not show any cytotoxicity at tested concentrations. At non-cytotoxic and subtoxic concentrations, Folpan 80 WG® was found to increase DCFH-DA fluorescence. Conclusion These results show that the particles of commercial forms of folpet are relatively stable over time. Particles could be easily inhaled by humans, could reach the conducting airways and are

  20. Canola Oil Fuel Cell Demonstration: Volume 3 - Technical, Commercialization, and Application Issues Associated with Harvested Biomass

    Science.gov (United States)

    2006-08-17

    series of steam- heated drum or stack-type cookers . Cooking serves to thermally rup- ture oil cells that have survived flaking; to reduce oil viscosity...Credit (Federal) The REPC provides a corporate tax credit of 1.5 cents/kWh, adjusted an- nually for inflation, for: solar thermal electric...such as solar energy, wind energy, geothermal energy, conversion of biomass, fuel cells that do not require hydrocarbon fuel, small hydroelectric

  1. Nanosecond pulsed laser ablated sub-10 nm silicon nanoparticles for improving photovoltaic conversion efficiency of commercial solar cells

    Science.gov (United States)

    Rasouli, H. R.; Ghobadi, A.; Ulusoy Ghobadi, T. G.; Ates, H.; Topalli, K.; Okyay, A. K.

    2017-10-01

    In this paper, we demonstrate the enhancement of photovoltaic (PV) solar cell efficiency using luminescent silicon nanoparticles (Si-NPs). Sub-10 nm Si-NPs are synthesized via pulsed laser ablation technique. These ultra-small Si nanoparticles exhibit photoluminescence (PL) character tics at 425 and 517 nm upon excitation by ultra-violet (UV) light. Therefore, they can act as secondary light sources that convert high energetic photons to ones at visible range. This down-shifting property can be a promising approach to enhance PV performance of the solar cell, regardless of its type. As proof-of-concept, polycrystalline commercial solar cells with an efficiency of ca 10% are coated with these luminescent Si-NPs. The nanoparticle-decorated solar cells exhibit up to 1.64% increase in the external quantum efficiency with respect to the uncoated reference cells. According to spectral photo-responsivity characterizations, the efficiency enhancement is stronger in wavelengths below 550 nm. As expected, this is attributed to down-shifting via Si-NPs, which is verified by their PL characteristics. The results presented here can serve as a beacon for future performance enhanced devices in a wide range of applications based on Si-NPs including PVs and LED applications.

  2. Roadmap for the international, accelerator-based neutrino programme

    Energy Technology Data Exchange (ETDEWEB)

    Cao, J. [Beijing, Inst. High Energy Phys. (China); de Gouvêa, A. [Northwestern Univ., Evanston, IL (United States); Duchesneau, D. [CNRS/IN2P3. Univ. Paris (France). Observatoire de Paris. AstroParticule et Cosmologie (APC); Geer, S. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Gomes, R. [Federal University of Goias (Brazil); Kim, S. B. [Seoul National Univ. (Korea, Republic of); Kobayashi, T. [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Long, K. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL); Maltoni, M. [Autonomous Univ. of Madrid (Spain); Mezzetto, M. [Univ. of Padua (Italy); Mondal, N. [Tata Inst. of Fundamental Research, Bombay (India); Shiozawa, M. [Univ. of Tokyo (Japan); Sobczyk, J. [Univ. of Wroclaw (Poland); Tanaka, H. A. [TRIUMF, Vancouver, BC (Canada); Wascko, M. [Imperial College, London (United Kingdom); Zeller, G. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2017-04-26

    In line with its terms of reference the ICFA Neutrino Panel has developed a roadmap for the international, accelerator-based neutrino programme. A "roadmap discussion document" was presented in May 2016 taking into account the peer-group-consultation described in the Panel's initial report. The "roadmap discussion document" was used to solicit feedback from the neutrino community---and more broadly, the particle- and astroparticle-physics communities---and the various stakeholders in the programme. The roadmap, the conclusions and recommendations presented in this document take into account the comments received following the publication of the roadmap discussion document. With its roadmap the Panel documents the approved objectives and milestones of the experiments that are presently in operation or under construction. Approval, construction and exploitation milestones are presented for experiments that are being considered for approval. The timetable proposed by the proponents is presented for experiments that are not yet being considered formally for approval. Based on this information, the evolution of the precision with which the critical parameters governinger the neutrino are known has been evaluated. Branch or decision points have been identified based on the anticipated evolution in precision. The branch or decision points have in turn been used to identify desirable timelines for the neutrino-nucleus cross section and hadro-production measurements that are required to maximise the integrated scientific output of the programme. The branch points have also been used to identify the timeline for the R&D required to take the programme beyond the horizon of the next generation of experiments. The theory and phenomenology programme, including nuclear theory, required to ensure that maximum benefit is derived from the experimental programme is also discussed.

  3. Evaluation of Roadmap to Achieve Energy Delivery Systems Cybersecurity

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, Adrian R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    The Department of Energy/Office of Electricity Delivery and Energy Reliability (DOE/OE) Cybersecurity for Energy Delivery Systems (CEDS) program is currently evaluating the Roadmap to Achieve Energy Delivery Systems Cybersecurity document that sets a vision and outlines a set of milestones. The milestones are divided into five strategic focus areas that include: 1. Build a Culture of Security; 2. Assess and Monitor Risk; 3. Develop and Implement New Protective Measures to Reduce Risk; 4. Manage Incidents; and 5. Sustain Security Improvements. The most current version of the roadmap was last updated in September of 2016. Sandia National Laboratories (SNL) has been tasked with revisiting the roadmap to update the current state of energy delivery systems cybersecurity protections. SNL is currently working with previous and current partners to provide feedback on which of the roadmap milestones have been met and to identify any preexisting or new gaps that are not addressed by the roadmap. The specific focus areas SNL was asked to evaluate are: 1. Develop and Implement New Protective Measures to Reduce Risk and 2. Sustain Security Improvements. SNL has formed an Industry Advisory Board (IAB) to assist in answering these questions. The IAB consists of previous partners on past CEDS funded efforts as well as new collaborators that have unique insights into the current state of cybersecurity within energy delivery systems. The IAB includes asset owners, utilities and vendors of control systems. SNL will continue to maintain regular communications with the IAB to provide various perspectives on potential future updates to further improve the breadth of cybersecurity coverage of the roadmap.

  4. Roadmap on biosensing and photonics with advanced nano-optical methods

    KAUST Repository

    Di Fabrizio, Enzo M.

    2016-05-10

    This roadmap, through the contributions of ten groups worldwide, contains different techniques, methods and materials devoted to sensing in nanomedicine. Optics is used in different ways in the detection schemes. Raman, fluorescence and infrared spectroscopies, plasmonics, second harmonic generation and optical tweezers are all used in applications from single molecule detection (both in highly diluted and in highly concentrated solutions) to single cell manipulation. In general, each optical scheme, through device miniaturization and electromagnetic field localization, exploits an intrinsic optical enhancement mechanism in order to increase the sensitivity and selectivity of the device with respect to the complex molecular construct. The materials used for detection include nanoparticles and nanostructures fabricated with different 2D and 3D lithographic methods. It is shown that sensitivity to a single molecule is already accessible whether the system under study is a single cell or a multitude of cells in a molecular mixture. Throughout the roadmap there is an attempt to foresee and to suggest future directions in this interdisciplinary field. © 2016 IOP Publishing Ltd.

  5. An assessment of the factors affecting the commercialization of cell-based therapeutics: a systematic review protocol.

    Science.gov (United States)

    Pettitt, David; Arshad, Zeeshaan; Davies, Benjamin; Smith, James; French, Anna; Cole, Doug; Bure, Kim; Dopson, Sue; DiGiusto, David; Karp, Jeff; Reeve, Brock; Barker, Richard; Holländer, Georg; Brindley, David

    2017-06-26

    Cellular-based therapies represent a platform technology within the rapidly expanding field of regenerative medicine and are distinct from conventional therapeutics-offering a unique approach to managing what were once considered untreatable diseases. Despite a significant increase in basic science activity within the cell therapy arena, alongside a growing portfolio of cell therapy trials and promising investment, the translation of cellular-based therapeutics from "bench to bedside" remains challenging, and the number of industry products available for widespread clinical use remains comparatively low. This systematic review identifies unique intrinsic and extrinsic barriers in the cell-based therapy domain. Eight electronic databases will be searched, specifically Medline, EMBASE (OvidSP), BIOSIS & Web of Science, Cochrane Library & HEED, EconLit (ProQuest), WHOLIS WHO Library Database, PAIS International (ProQuest), and Scopus. Addition to this gray literature was searched by manually reviewing relevant work. All identified articles will be subjected for review by two authors who will decide whether or not each article passes our inclusion/exclusion criteria. Eligible papers will subsequently be reviewed, and key data extracted into a pre-designed data extraction scorecard. An assessment of the perceived impact of broad commercial barriers to the adoption of cell-based therapies will be conducted. These broad categories will include manufacturing, regulation and intellectual property, reimbursement, clinical trials, clinical adoption, ethics, and business models. This will inform further discussion in the review. There is no PROSPERO registration number. Through a systematic search and appraisal of available literature, this review will identify key challenges in the commercialization pathway of cellular-based therapeutics and highlights significant barriers impeding successful clinical adoption. This will aid in creating an adaptable, acceptable, and

  6. HTA Implementation Roadmap in Central and Eastern European Countries

    DEFF Research Database (Denmark)

    Kaló, Zoltán; Gheorghe, Adrian; Huic, Mirjana

    2016-01-01

    to healthcare financing decisions can improve the allocative efficiency of scarce resources. However, few CEE countries have a clear roadmap for HTA implementation. Examples from high-income countries may not be directly relevant, as CEE countries cannot allocate so much financial and human resources......, use of local data, scope of mandatory HTA, decision criteria, and international collaboration in HTA. Although HTA implementation strategies from the region can be relevant examples for other CEE countries with similar cultural environment and economic status, HTA roadmaps are not still fully...

  7. The Roadmap to achieve EU goals on urban mobility

    DEFF Research Database (Denmark)

    Sørensen, Claus Hedegaard; Gudmundsson, Henrik; Schippl, Jens

    2015-01-01

    Is it possible to change urban mobility in Europe to achieve ambitious sustainability goals? If so, who should dowhat by when? These questions are answered in a new Roadmap on urban mobility prepared as part of the European FP7 research project TRANSFORuM.......Is it possible to change urban mobility in Europe to achieve ambitious sustainability goals? If so, who should dowhat by when? These questions are answered in a new Roadmap on urban mobility prepared as part of the European FP7 research project TRANSFORuM....

  8. The anatomy of a distributed motion planning roadmap

    KAUST Repository

    Jacobs, Sam Ade

    2014-09-01

    © 2014 IEEE. In this paper, we evaluate and compare the quality and structure of roadmaps constructed from parallelizing sampling-based motion planning algorithms against that of roadmaps constructed using sequential planner. Also, we make an argument and provide experimental results that show that motion planning problems involving heterogenous environments (common in most realistic and large-scale motion planning) is a natural fit for spatial subdivision-based parallel processing. Spatial subdivision-based parallel processing approach is suited for heterogeneous environments because it allows for local adaption in solving a global problem while taking advantage of scalability that is possible with parallel processing.

  9. Technology Roadmapping for Renewable Fuels: Case of Biobutanol in Brazil

    Directory of Open Access Journals (Sweden)

    Julio Cesar Natalense

    2013-12-01

    Interviews have been used in the roadmapping process as an alternative to the workshops on market, product and technology. It allows the participation of companies in a highly competitive environment. The use of interviews allows the information to be collected individually, contributing to the elaboration of a roadmap. The results show that sugar cane has the potential to be used as a feedstock in the biobutanol production process, enabling Brazil to become a key exporter to supply other countries. For the short future, biobutanol has the potential to be produced in Brazil to replace petro-butanol as a solvent in industrial applications and to build the export platform for the fuels market .

  10. Interactive navigation of heterogeneous agents using adaptive roadmaps.

    Science.gov (United States)

    Gayle, Russell; Sud, Avneesh; Andersen, Erik; Guy, Stephen J; Lin, Ming C; Manocha, Dinesh

    2009-01-01

    We present a novel algorithm for collision-free navigation of a large number of independent agents in complex and dynamic environments. We introduce adaptive roadmaps to perform global path planning for each agent simultaneously. Our algorithm takes into account dynamic obstacles and interagents interaction forces to continuously update the roadmap based on a physically-based dynamics simulator. In order to efficiently update the links, we perform adaptive particle-based sampling along the links. We also introduce the notion of 'link bands' to resolve collisions among multiple agents. In practice, our algorithm can perform real-time navigation of hundreds and thousands of human agents in indoor and outdoor scenes.

  11. Eliminating Light-Induced Degradation in Commercial p-Type Czochralski Silicon Solar Cells

    Directory of Open Access Journals (Sweden)

    Brett Hallam

    2017-12-01

    Full Text Available This paper discusses developments in the mitigation of light-induced degradation caused by boron-oxygen defects in boron-doped Czochralski grown silicon. Particular attention is paid to the fabrication of industrial silicon solar cells with treatments for sensitive materials using illuminated annealing. It highlights the importance and desirability of using hydrogen-containing dielectric layers and a subsequent firing process to inject hydrogen throughout the bulk of the silicon solar cell and subsequent illuminated annealing processes for the formation of the boron-oxygen defects and simultaneously manipulate the charge states of hydrogen to enable defect passivation. For the photovoltaic industry with a current capacity of approximately 100 GW peak, the mitigation of boron-oxygen related light-induced degradation is a necessity to use cost-effective B-doped silicon while benefitting from the high-efficiency potential of new solar cell concepts.

  12. Used fuel disposition research and development roadmap - FY10 status.

    Energy Technology Data Exchange (ETDEWEB)

    Nutt, W. M. (Nuclear Engineering Division)

    2010-10-01

    Since 1987 the U.S. has focused research and development activities relevant to the disposal of commercial used nuclear fuel and U.S. Department of Energy (DOE) owned spent nuclear fuel and high level waste on the proposed repository at Yucca Mountain, Nevada. At the same time, the U.S. successfully deployed a deep geologic disposal facility for defense-related transuranic waste in bedded salt at the Waste Isolation Pilot Plant. In 2009 the DOE established the Used Fuel Disposition Campaign (UFDC) within the Office of Nuclear Energy. The Mission of the UFDC is to identify alternatives and conduct scientific research and technology development to enable storage, transportation and disposal of used nuclear fuel and wastes generated by existing and future nuclear fuel cycles. The U.S. national laboratories have participated on these programs and has conducted research and development related to these issues to a limited extent. However, a comprehensive research and development (R&D) program investigating a variety of geologic media has not been a part of the U.S. waste management program since the mid 1980s. Such a comprehensive R&D program is being developed in the UFDC with a goal of meeting the UFDC Grand Challenge to provide a sound technical basis for absolute confidence in the safety and security of long-term storage, transportation, and disposal of used nuclear fuel and wastes from the nuclear energy enterprise. The DOE has decided to no longer pursue the development of a repository at Yucca Mountain, Nevada. Since a repository site will ultimately have to be selected, sited, characterized, designed, and licensed, other disposal options must now be considered. In addition to the unsaturated volcanic tuff evaluated at Yucca Mountain, several different geologic media are under investigation internationally and preliminary assessments indicate that disposal of used nuclear fuel and high level waste in these media is feasible. Considerable progress has been made in

  13. Hazards, Safety and Design Considerations for Commercial Lithium-ion Cells and Batteries

    Science.gov (United States)

    Jeevarajan, Judith

    2007-01-01

    This viewgraph presentation reviews the features of the Lithium-ion batteries, particularly in reference to the hazards and safety of the battery. Some of the characteristics of the Lithium-ion cell are: Highest Energy Density of Rechargeable Battery Chemistries, No metallic lithium, Leading edge technology, Contains flammable electrolyte, Charge cut-off voltage is critical (overcharge can result in fire), Open circuit voltage higher than metallic lithium anode types with similar organic electrolytes. Intercalation is a process that places small ions in crystal lattice. Small ions (such as lithium, sodium, and the other alkali metals) can fit in the interstitial spaces in a graphite lattice. These metallic ions can go farther and force the graphitic planes apart to fit two, three, or more layers of metallic ions between the carbon sheets. Other features of the battery/cell are: The graphite is conductive, Very high energy density compared to NiMH or NiCd, Corrosion of aluminum occurs very quickly in the presence of air and electrolyte due to the formation of HF from LiPF6 and HF is highly corrosive. Slides showing the Intercalation/Deintercalation and the chemical reactions are shown along with the typical charge/discharge for a cylindrical cell. There are several graphs that review the hazards of the cells.

  14. The European Lead Fast Reactor Strategy and the Roadmap for the Demonstrator ALFRED

    International Nuclear Information System (INIS)

    Alemberti, A.; De Bruyn, D.; Grasso, G.; Mansani, L.; Mattioli, D.; Roelofs, F.

    2013-01-01

    Expected impacts: → To ensure that nuclear energy remains a long-term contributor to a low carbon economy it is necessary to increase its sustainability through demonstrating the technical, industrial and economic viability of Gen IV fast nuclear reactors; → With the construction and operation of MYRRHA and ALFRED, Europe will be in an excellent position to secure the development of a safe, sustainable and competitive fast nuclear technology; → ALFRED Demonstrator Roadmap will: • play a key role by involving European industry and maintaining and developing European leadership in nuclear technologies worldwide; • allow to investigate and address the main technological issues that can be implemented in the LFR prototype (2035); • make possible commercial deployment, by the European industry, of these technologies by 2050 and beyond; • contribute significantly to the development of a sustainable and secure energy supply for Europe from the second half of this century onwards

  15. A technology roadmap of smart biosensors from conventional glucose monitoring systems.

    Science.gov (United States)

    Shende, Pravin; Sahu, Pratiksha; Gaud, Ram

    2017-06-01

    The objective of this review article is to focus on technology roadmap of smart biosensors from a conventional glucose monitoring system. The estimation of glucose with commercially available devices involves analysis of blood samples that are obtained by pricking finger or extracting blood from the forearm. Since pain and discomfort are associated with invasive methods, the non-invasive measurement techniques have been investigated. The non-invasive methods show advantages like non-exposure to sharp objects such as needles and syringes, due to which there is an increase in testing frequency, improved control of glucose concentration and absence of pain and biohazard materials. This review study is aimed to describe recent invasive techniques and major noninvasive techniques, viz. biosensors, optical techniques and sensor-embedded contact lenses for glucose estimation.

  16. LiquidPower-1. Development and proof-of-concept of core methanol reformer for stationary and motive fuel cell systems and hydrogen refuelling stations. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Krogsgaard, J.; Mortensen, Henrik [H2 Logic A/S, Herning (Denmark); Skipper, T. [Dantherm Power A/S, Hobro (Denmark)

    2013-03-15

    LiquidPower-1 has developed laboratory test systems for methanol reforming and tested reformers from four different suppliers. This has contributed to determining the state-of-the-art level for methanol reforming and enabled an update of the LiquidPower R and D Roadmap onwards a commercialisation of the technology. The project has achieved the following results: 1) A detailed technical specification of methanol reformers for the fuel cell back-up power and hydrogen refueling station markets has been conducted; 2) Laboratory test systems for methanol reformers has been developed and established at Dantherm Power and H2 Logic; 3) Initial test of reformers from four suppliers has been conducted - with two suppliers being selected for continued tests; 4) Extensive laboratory tests conducted of reformers from two suppliers, with the aim to determine state-of-the-art for price, efficiency, capacity and lifetime. Several errors and break-downs were experienced during the test period, which revealed a need for further R and D to improve lifetime and stability; 5) The LiquidPower F and U Roadmap has been updated. Reformer TCO targets (Total Cost of Operation) for each of the markets have been calculated including updated targets for efficiency and cost. These targets also serve as the main ones to be pursued as part of the continued R and D roadmap execution. Compared to the previous edition of the Roadmap, the project has confirmed the viability of methanol reforming, but also revealed that stability and lifetime needs to be addressed and solved before commencing commercialization of the technology. If the Roadmap is successful a commercialization can commence beyond 2015. (Author)

  17. Evaluation of Commercial Off-the-Shelf Solutions for Supporting Viability Retention of Yersinia Pestis Cells

    Science.gov (United States)

    2017-11-01

    viability Biosampling Improved sampling kits 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18. NUMBER OF...the Y. pestis A1122 strain cells on two different surfaces (stainless steel and painted concrete) were studied. 2 2. MATERIALS AND METHODS 2.1...in a laboratory shaker at 30 °C at 200 rpm for 48 h. At the end of this incubation, 1 mL of inoculum was spotted on 2 × 2 in. stainless steel (R.G

  18. Scenario-based roadmapping assessing nuclear technology development paths for future nuclear energy system scenarios

    International Nuclear Information System (INIS)

    Van Den Durpel, Luc; Roelofs, Ferry; Yacout, Abdellatif

    2009-01-01

    Nuclear energy may play a significant role in a future sustainable energy mix. The transition from today's nuclear energy system towards a future more sustainable nuclear energy system will be dictated by technology availability, energy market competitiveness and capability to achieve sustainability through the nuclear fuel cycle. Various scenarios have been investigated worldwide each with a diverse set of assumptions on the timing and characteristics of new nuclear energy systems. Scenario-based roadmapping combines the dynamic scenario-analysis of nuclear energy systems' futures with the technology roadmap information published and analysed in various technology assessment reports though integrated within the nuclear technology roadmap Nuclear-Roadmap.net. The advantages of this combination is to allow mutual improvement of scenario analysis and nuclear technology roadmapping providing a higher degree of confidence in the assessment of nuclear energy system futures. This paper provides a description of scenario-based roadmapping based on DANESS and Nuclear-Roadmap.net. (author)

  19. Commercialization of bacterial cell factories for the sustainable production of polyhydroxyalkanoate thermoplastics: progress and prospects.

    Science.gov (United States)

    Kumar, Abhishek; Srivastava, Janmejai K; Mallick, Nirupama; Singh, Akhilesh K

    2015-01-01

    Ubiquitous conventional plastics, generally manufactured from finite, nonsustainable fossil fuels are non-biodegradable wonder entities but their ill effect on Mother Nature has subsequently raised major environmental concerns like their safe disposal, solid waste management and several potential hazards. Such concerns have fuelled initiatives for research globally towards development of sustainable and eco-friendly bioplastics. The new generation of plastics called 'bioplastics' are polymers of long chain of repeating monomer units that are classified as photodegradable, semi-biodegradable, chemically synthesized and polyhydroxyalkanoates (PHAs). The commonly emerged novel bioplastics are polyesters of hydroxyalkanoates (HAs) called PHAs, which are lipoidic storage materials found in the cytosol of vast and diverse forms of bacteria. Among 150 different PHAs known so far, poly- 3-hydroxybutyrate is the most common and comprehensively characterized PHA. Interestingly, PHAs are only completely biodegradable plastics with material properties comparable to conventional plastics that can be achieved by regulating the co-monomers incorporation into PHAs backbone. PHA bioplastics are exploited in the form of user-friendly goods viz. films, absorbable sutures, bone plates, drug carriers, etc. Besides advantages, such useful entity(s) has major shortcomings as well like high production cost compared to conventional plastics. Precisely, in PHAs production, about fifty percent of the overall price is due to the carbon substrates. Consequently, exploring novel cost-effective substrates is a major compulsion for successful commercialization of this bioplastic, which is anticipated to reduce the cost of production as a result of advancing and intensifying research work. This review presents an insight and patent developments in the field of PHAs bioplastics.

  20. CyberGIS software: a synthetic review and integration roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Shaowen [University of Illinois, Urbana-Champaign; Anselin, Luc [Arizona State University; Bhaduri, Budhendra L [ORNL; Cosby, Christopher [University Navstar Consortium, Boulder, CO; Goodchild, Michael [University of California, Santa Barbara; Liu, Yan [University of Illinois, Urbana-Champaign; Nygers, Timothy L. [University of Washington, Seattle

    2013-01-01

    CyberGIS defined as cyberinfrastructure-based geographic information systems (GIS) has emerged as a new generation of GIS representing an important research direction for both cyberinfrastructure and geographic information science. This study introduces a 5-year effort funded by the US National Science Foundation to advance the science and applications of CyberGIS, particularly for enabling the analysis of big spatial data, computationally intensive spatial analysis and modeling (SAM), and collaborative geospatial problem-solving and decision-making, simultaneously conducted by a large number of users. Several fundamental research questions are raised and addressed while a set of CyberGIS challenges and opportunities are identified from scientific perspectives. The study reviews several key CyberGIS software tools that are used to elucidate a vision and roadmap for CyberGIS software research. The roadmap focuses on software integration and synthesis of cyberinfrastructure, GIS, and SAM by defining several key integration dimensions and strategies. CyberGIS, based on this holistic integration roadmap, exhibits the following key characteristics: high-performance and scalable, open and distributed, collaborative, service-oriented, user-centric, and community-driven. As a major result of the roadmap, two key CyberGIS modalities gateway and toolkit combined with a community-driven and participatory approach have laid a solid foundation to achieve scientific breakthroughs across many geospatial communities that would be otherwise impossible.

  1. European IST-programme roadmap for Optical Communications

    DEFF Research Database (Denmark)

    Ackaert, Ann; Demeester, Piet; Lagasse, Paul

    2003-01-01

    On the basis of European IST project results in the field of photonics, the OPTIMIST thematic network has produced a roadmap for optical communications. This work is described in the present article which provides scenarios for the evolution of the optical network in the coming 10 years. Predicta...

  2. Synthesis-Spectroscopy Roadmap Problems: Discovering Organic Chemistry

    Science.gov (United States)

    Kurth, Laurie L.; Kurth, Mark J.

    2014-01-01

    Organic chemistry problems that interrelate and integrate synthesis with spectroscopy are presented. These synthesis-spectroscopy roadmap (SSR) problems uniquely engage second-year undergraduate organic chemistry students in the personal discovery of organic chemistry. SSR problems counter the memorize-or-bust strategy that many students tend to…

  3. A strategic surety roadmap for high consequence software

    Energy Technology Data Exchange (ETDEWEB)

    Pollock, G.M.; Dalton, L.J.

    1995-12-31

    A strategic surety roadmap for high consequence software systems developed under the High Integrity Software (HIS) Program at Sandia National Laboratories is presented. Selected research tracks are identified and described detailing current technology and outlining advancements to be pursued over the coming decade to reach HIS goals.

  4. Local randomization in neighbor selection improves PRM roadmap quality

    KAUST Repository

    McMahon, Troy

    2012-10-01

    Probabilistic Roadmap Methods (PRMs) are one of the most used classes of motion planning methods. These sampling-based methods generate robot configurations (nodes) and then connect them to form a graph (roadmap) containing representative feasible pathways. A key step in PRM roadmap construction involves identifying a set of candidate neighbors for each node. Traditionally, these candidates are chosen to be the k-closest nodes based on a given distance metric. In this paper, we propose a new neighbor selection policy called LocalRand(k,K\\'), that first computes the K\\' closest nodes to a specified node and then selects k of those nodes at random. Intuitively, LocalRand attempts to benefit from random sampling while maintaining the higher levels of local planner success inherent to selecting more local neighbors. We provide a methodology for selecting the parameters k and K\\'. We perform an experimental comparison which shows that for both rigid and articulated robots, LocalRand results in roadmaps that are better connected than the traditional k-closest policy or a purely random neighbor selection policy. The cost required to achieve these results is shown to be comparable to k-closest. © 2012 IEEE.

  5. A National Roadmap for Vadose Zone Science and Technology

    Energy Technology Data Exchange (ETDEWEB)

    Kowall, Stephen Jacob

    2001-08-01

    This roadmap is a means of achieving, to the best of our current knowledge, a reasonable scientific understanding of how contaminants of all forms move in the vadose geological environments. This understanding is needed to reduce the present uncertainties in predicting contaminant movement, which in turn will reduce the uncertainties in remediation decisions.

  6. Calendar aging of commercial graphite/LiFePO4 cell - Predicting capacity fade under time dependent storage conditions

    Science.gov (United States)

    Grolleau, Sébastien; Delaille, Arnaud; Gualous, Hamid; Gyan, Philippe; Revel, Renaud; Bernard, Julien; Redondo-Iglesias, Eduardo; Peter, Jérémy

    2014-06-01

    In applications such as electrical transportation, most of the battery life is spent under storage. Understanding and estimating aging under storage, also named as calendar aging, is therefore a prerequisite for cell life prediction. This work investigates aging behavior upon storage of a commercial 15 Ah lithium-ion graphite/iron phosphate cell. Performance decline during 450 days of storage under nine stationary conditions is analyzed using non-destructive electrochemical tests. Temperature is found to be more detrimental than State of Charge (SoC). Most often, degradation models express the accumulated degradation with respect to time and aging conditions. In this article, a simple modeling approach is proposed focusing on the degradation rate to predict capacity fade. This permits predicting cell degradation under time dependent storage conditions (SoC and temperature) which are usually experienced in real applications. Model prediction is compared to experimental calendar aging data obtained over 625 days in a controlled time dependent temperature storage conditions. Predictions are in good agreement with experimental results as the absolute error on capacity prediction never exceeds 3% over 400 days and 5% over 625 days.

  7. Analog front-end cell designed in a commercial 025 mu m process for the ATLAS pixel detector at LHC

    CERN Document Server

    Blanquart, L; Comes, G; Denes, P; Einsweiler, Kevin F; Fischer, P; Mandelli, E; Meddeler, G; Peric, I; Richardson, J

    2002-01-01

    A new analog pixel front-end cell has been developed for the ATLAS detector at the future Large Hadron Collider (LHC) at the European Laboratory for Particle Physics (CERN). This analog cell has been submitted in two commercial 0.25 mu m CMOS processes (in an analog test chip format), using special layout techniques for radiation hardness purposes. It is composed of two cascaded amplifiers followed by a fast discriminator featuring a detection threshold within the range of 1000 to 10000 electrons. The first preamplifier has the principal role of providing a large bandwidth, low input impedance, and fast rise time in order to enhance the time-walk and crosstalk performance, whereas the second fully differential amplifier is aimed at delivering a sufficiently high-voltage gain for optimum comparison. A new do feedback concept renders the cell tolerant of sensor leakage current up to 300 nA and provides monitoring of this current. Two 5-bit digital-to-analog converters tolerant to single- event upset have been i...

  8. A Lunar Surface System Supportability Technology Development Roadmap

    Science.gov (United States)

    Oeftering, Richard C.; Struk, Peter M.; Taleghani, barmac K.

    2011-01-01

    This paper discusses the establishment of a Supportability Technology Development Roadmap as a guide for developing capabilities intended to allow NASA s Constellation program to enable a supportable, sustainable and affordable exploration of the Moon and Mars. Presented is a discussion of supportability, in terms of space facility maintenance, repair and related logistics and a comparison of how lunar outpost supportability differs from the International Space Station. Supportability lessons learned from NASA and Department of Defense experience and their impact on a future lunar outpost is discussed. A supportability concept for future missions to the Moon and Mars that involves a transition from a highly logistics dependent to a logistically independent operation is discussed. Lunar outpost supportability capability needs are summarized and a supportability technology development strategy is established. The resulting Lunar Surface Systems Supportability Strategy defines general criteria that will be used to select technologies that will enable future flight crews to act effectively to respond to problems and exploit opportunities in an environment of extreme resource scarcity and isolation. This strategy also introduces the concept of exploiting flight hardware as a supportability resource. The technology roadmap involves development of three mutually supporting technology categories, Diagnostics Test and Verification, Maintenance and Repair, and Scavenging and Recycling. The technology roadmap establishes two distinct technology types, "Embedded" and "Process" technologies, with different implementation and thus different criteria and development approaches. The supportability technology roadmap addresses the technology readiness level, and estimated development schedule for technology groups that includes down-selection decision gates that correlate with the lunar program milestones. The resulting supportability technology roadmap is intended to develop a set

  9. A roadmap for photovoltaic-thermal panels. Combination of techniques offers many advantages; Een roadmap voor pv-thermische panelen. Combinatie van technieken biedt vele voordelen

    Energy Technology Data Exchange (ETDEWEB)

    Zondag, H.A.; Van Helden, W.G.J.; Bakker, M. [ECN Energie Gebouwde Omgeving en Netten, Petten (Netherlands)

    2006-10-15

    In PVT technology, heat is extracted from PV cells. In this way, a device is made that produces both electricity and heat. In the EU funded coordination action PV-Catapult, workshops on PVT were organised at the PVSEC 2004 Conference in Paris and the Eurosun 2004 conference in Freiburg, to obtain active participation of the PV and solar thermal communities. Currently, the results of the workshops are used in the drafting of a roadmap for the large scale introduction of PVT technology on the market. First results will be presented here. [Dutch] Zonnepanelen (oftewel pv-panelen) produceren elektriciteit uit zonlicht. In de volle zon kan de temperatuur van zonnepanelen flink oplopen. Gewone zonnepanelen maken van deze warmte geen gebruik, maar in PVT-modules (pv-thermische modules) wordt deze warmte benut voor de productie van warm water of warme lucht. Het resultaat is een apparaat dat zowel warmte als stroom produceert uit zonlicht.

  10. Higher Americium Oxidation State Research Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Mincher, Bruce J. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Law, Jack D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Goff, George S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Moyer, Bruce A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burns, Jon D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lumetta, Gregg J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sinkov, Sergey I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Shehee, Thomas C. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Hobbs, David T. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-12-18

    -solvent-extraction separations are also under investigation. The first would separate Am(VI) by co-crystallization with uranium and the other oxidizable actinides as their nitrate salts. This novel idea has been successful in lab scale testing, and merits further investigation. Similarly, success has been achieved in separations using inorganic or hybrid ion exchange materials to sorb the lanthanides and actinides, while allowing pentavalent americium to elute. This is the only technique currently investigating Am(V), despite the advantages of this oxidation state with regard to its higher stability. The ultimate destination for this roadmap is to develop an americium separation that can be applied under process conditions, preferably affording a co-separation of the actinyl (VI) ions. Toward that end, emphasis is given here to selection of a solvent extraction flowsheet for testing in the INL centrifugal contactor hot test bed during FY16. A solvent extraction process will be tested mainly because solvent extraction separations of Am(VI) are relatively mature and the test bed currently exists in a configuration to support them. Thus, a major goal of FY16 is to select the oxidant/ligand combination to run such a test using the contactors. The only ligands under consideration are DAAP and DEHBA. This is not to say that ion exchange and co-crystallization techniques are unimportant. They merit continued investigation, but are not mature enough for hot test bed testing at this time.

  11. A Roadmap for NEAMS Capability Transfer

    Energy Technology Data Exchange (ETDEWEB)

    Bernholdt, David E [ORNL

    2011-11-01

    The vision of the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program is to bring truly predictive modeling and simulation (M&S) capabilities to the nuclear engineering community in order to enable a new approach to the design and analysis of nuclear energy systems. From its inception, the NEAMS program has always envisioned a broad user base for its software and scientific products, including researchers within the DOE complex, nuclear industry technology developers and vendors, and operators. However activities to date have focused almost exclusively on interactions with NEAMS sponsors, who are also near-term users of NEAMS technologies. The task of the NEAMS Capability Transfer (CT) program element for FY2011 is to develop a comprehensive plan to support the program's needs for user outreach and technology transfer. In order to obtain community input to this plan, a 'NEAMS Capability Transfer Roadmapping Workshop' was held 4-5 April 2011 in Chattanooga, TN, and is summarized in this report. The 30 workshop participants represented the NEAMS program, the DOE and industrial user communities, and several outside programs. The workshop included a series of presentations providing an overview of the NEAMS program and presentations on the user outreach and technology transfer experiences of (1) The Advanced Simulation and Computing (ASC) program, (2) The Standardized Computer Analysis for Licensing Evaluation (SCALE) project, and (3) The Consortium for Advanced Simulation of Light Water Reactors (CASL), followed by discussion sessions. Based on the workshop and other discussions throughout the year, we make a number of recommendations of key areas for the NEAMS program to develop the user outreach and technology transfer activities: (1) Engage not only DOE, but also industrial users sooner and more often; (2) Engage with the Nuclear Regulatory Commission to facilitate their understanding and acceptance of NEAMS approach to predictive M&S; (3

  12. Energy Road-map 2050: Towards regional and local energy Road-maps. IMAGINE seminar 2011

    International Nuclear Information System (INIS)

    Maillot, Herve; Pidoux, Blandine

    2011-11-01

    The 2011 IMAGINE Seminar held in Brussels on 9 November 2011 united around fifty representatives from Energy Cities network member cities as well as representatives from the European Parliament and the Commission, various industrial sectors and civil society organisations. Participants were invited to share their visions of their action by 2040-2050 in a sustainable and desirable city, having achieved its energy transition. The spontaneous and inspiring discussions that followed broached the following questions: - What is and should be the role of the local level in the EU Energy Road-map? - What if European local authorities were to develop their own 'Energy 2050' Road-maps? - What local and regional policies can social and economic players use for contributing to achieving European targets? - Under what conditions is the 'low energy cities with a high quality of life for all' concept relevant? The debate helped outline a shared, global vision as a step towards European collective dynamics giving territories a major role in energy transition. At the end of the day, participants from very different backgrounds converged on the following key points: - Like European institutions, territories must develop a long-term vision, failing which they will be unable to take meaningful action, mobilise players and make the right decisions in the short-term. - The energy-territory relationship, from efficient energy use to supply policies, is a major democratic challenge. - Although a number of technologies are already available, they still have to be integrated so that citizens can satisfy their needs and become fully accountable for their energy use. - Energy strategies must help meet a number of local challenges: social and territorial cohesion, employment and economic development, environmental protection and quality of life. To do so, they need to be designed taking those they are supposed to serve, i.e. citizens, into consideration. - The interaction

  13. Cytogenetic effects of commercial formulation of cypermethrin in root meristem cells of Allium sativum: spectroscopic basis of chromosome damage.

    Science.gov (United States)

    Saxena, P N; Chauhan, L K S; Gupta, S K

    2005-12-15

    To validate the use of Allium sativum as a sensitive test model for genotoxicity, the cytogenetic effects of a commercial formulation of the pyrethroid insecticide, cypermethrin, were evaluated in the root meristem cells of A. sativum. Ultraviolet (UV) and Fourier transform infrared (FTIR) spectral measurements were also carried out to understand the interaction of cypermethrin with DNA. In a preliminary toxicity assay, the EC50 for Allium root growth was estimated to be 8 ppm. For the cytogenetic assay, root meristem cells were exposed to 1, 2, 4, 8 and 16 ppm of the test compound for 24 h, and either processed immediately for analysis or incubated in water for 24 h of recovery and then processed. Cells analyzed immediately after the exposure had a significant, dose-dependent inhibition of mitotic index (MI) and induction of mitotic and chromosomal aberrations (MAs and CAs). The 24 h recovery period reduced the effect of the test compound on the MI and percent aberrations; however, cells exposed to 8 and 16 ppm showed a significant frequency of aberrations despite the recovery period. One part per million cypermethrin was consistently negative in the assay. The data indicate that higher doses of cypermethrin produce toxicity, CAs and MAs in A. sativum. The present study indicates that A. sativum is a sensitive and reliable test system. A bathochromic shift observed in UV absorption spectra reveals that cypermethrin binds with DNA. Role of vibrational modes of the active site in the recognition and reaction of cypermethrin with DNA has been discussed. Based on spectroscopic data and structural properties, a possible mechanism has been proposed for the interaction of cypermethrin with DNA resulting in chromosomal aberrations.

  14. A European Roadmap for Research in Astrobiology - The AstRoMap Roadmap

    Science.gov (United States)

    Gómez, F.; Walter, N.; Horneck, G.; Muller, C.; Rettberg, P.; Capria, M.; Palomba, E.

    2015-10-01

    AstRoMap (Astrobiology Road Mapping activity-www.astromap-eu.org) is a collaborative project which will provide the European Planetary Science Community with a road map in astrobiology. The goals of the project have been: (i) to pose big questions related to astrobiology; and (ii) the identification of experiments, new technology and/or those space missions to be developed in future programs and which could answer those big questions. This collaborative infrastructure includes the organization of expert panels and international workshops in order to discuss about those big questions and the science objectives by the community to be addressed. The main deliverable will be a Roadmap document. The project is steered by a consortium of six European and national research institutes and associations: -­- Centro de Astrobiologica (INTACSIC), Spain -­- European Science Foundation, France -­- Association pour un Réseau Européen d'Exo/Astrobiology (EANA), France -­- B-USOC, Belgium -­- Deutsches Zentrum für Luft- und Raumfahrt (DLR), Germany -­- National Institute for Astrophysics (INAF), ItalyOrigin and evolution of planetary systems -­- Origin of organic compounds in space -­- Rock-water-carbon interactions, organic synthesis, and steps to life -­- Life and habitability on Earth and in Space -­- -­- Biosignatures as facilitating life detection The key topics will focus on a limited number of strategic scientific objectives to be addressed in the next 20 years by European astrobiologists, and suggest research activities for future development.

  15. The 2016 oxide electronic materials and oxide interfaces roadmap

    International Nuclear Information System (INIS)

    Lorenz, M; Grundmann, M; Ramachandra Rao, M S; Mukherjee, J; Priyadarshini, M; Venkatesan, T; Fortunato, E; Barquinha, P; Branquinho, R; Salgueiro, D; Martins, R; Carlos, E; Liu, A; Shan, F K; Boschker, H; DasGupta, N; Rogers, D J; Teherani, F H; Sandana, E V; Bove, P

    2016-01-01

    Oxide electronic materials provide a plethora of possible applications and offer ample opportunity for scientists to probe into some of the exciting and intriguing phenomena exhibited by oxide systems and oxide interfaces. In addition to the already diverse spectrum of properties, the nanoscale form of oxides provides a new dimension of hitherto unknown phenomena due to the increased surface-to-volume ratio. Oxide electronic materials are becoming increasingly important in a wide range of applications including transparent electronics, optoelectronics, magnetoelectronics, photonics, spintronics, thermoelectrics, piezoelectrics, power harvesting, hydrogen storage and environmental waste management. Synthesis and fabrication of these materials, as well as processing into particular device structures to suit a specific application is still a challenge. Further, characterization of these materials to understand the tunability of their properties and the novel properties that evolve due to their nanostructured nature is another facet of the challenge. The research related to the oxide electronic field is at an impressionable stage, and this has motivated us to contribute with a roadmap on ‘oxide electronic materials and oxide interfaces’. This roadmap envisages the potential applications of oxide materials in cutting edge technologies and focuses on the necessary advances required to implement these materials, including both conventional and novel techniques for the synthesis, characterization, processing and fabrication of nanostructured oxides and oxide-based devices. The contents of this roadmap will highlight the functional and correlated properties of oxides in bulk, nano, thin film, multilayer and heterostructure forms, as well as the theoretical considerations behind both present and future applications in many technologically important areas as pointed out by Venkatesan. The contributions in this roadmap span several thematic groups which are represented by

  16. Comparative studies on the chemical and cell-based antioxidant activities and antitumor cell proliferation properties of soy milk manufactured by conventional and commercial UHT methods.

    Science.gov (United States)

    Xu, Baojun; Chang, Sam K C; Liu, Zhisheng; Yuan, Shaohong; Zou, Yanping; Tan, Yingying

    2010-03-24

    The aims of this work were to compare antiproliferation, antioxidant activities and total phytochemicals and individual isoflavone profiles in soy milk processed by various methods including traditional stove cooking, direct steam injection, direct ultrahigh temperature (UHT), indirect UHT, and a two-stage simulated industry method, and a selected commercial soy milk product. Various processing methods significantly affected total saponin, phytic acid, and total phenolic content and individual isoflavone distribution. The laboratory UHT and the two-stage processed soy milk exhibited relatively higher total phenolic content, total flavonoid content, saponin and phytic acid than those processed by the traditional and steam processed methods. Thermal processing caused obvious intertransformation but did not cause severe degradation except for breaking down of aglycons. Thermal processing significantly increased antioxidant capacities of soy milk determined by chemical analyses, but decreased cellular antioxidant capacities as compared to the raw soy milk. The raw and all processed soy milk exhibited antipoliferative activities against human HL-60 leukemia cells, AGS gastric tumor cells, and DU145 prostate cancer cells in a dose-dependent manner. The raw soy milk, but not the processed soy milk, exhibited a dose-dependent antiproliferative effect against colorectal adenocarcinoma Caco-2 cells. Taken together, these results indicate that various thermal processing methods change not only phytochemcials but also potential health-promoting effects of soy milk.

  17. Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, K.L.; Ramuhali, P.; Brenchley, D.L.; Coble, J.B.; Hashemian, H.M.; Konnick, R.; Ray, S.

    2012-09-01

    Executive Summary [partial] The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. A workshop was held to gather subject matter experts to develop the NDE R&D Roadmap for Cables. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, and NDE instrumentation development from the U.S. Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineering Laboratory), universities, commercial NDE service vendors and cable manufacturers, and the Electric Power Research Institute (EPRI).

  18. Light Water Reactor Sustainability (LWRS) Program – Non-Destructive Evaluation (NDE) R&D Roadmap for Determining Remaining Useful Life of Aging Cables in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, Kevin L.; Ramuhalli, Pradeep; Brenchley, David L.; Coble, Jamie B.; Hashemian, Hash; Konnik, Robert; Ray, Sheila

    2012-09-14

    The purpose of the non-destructive evaluation (NDE) R&D Roadmap for Cables is to support the Materials Aging and Degradation (MAaD) R&D pathway. The focus of the workshop was to identify the technical gaps in detecting aging cables and predicting their remaining life expectancy. The workshop was held in Knoxville, Tennessee, on July 30, 2012, at Analysis and Measurement Services Corporation (AMS) headquarters. The workshop was attended by 30 experts in materials, electrical engineering, U.S. Nuclear Regulatory Commission (NRC), U.S. Department of Energy (DOE) National Laboratories (Oak Ridge National Laboratory, Pacific Northwest National Laboratory, Argonne National Laboratory, and Idaho National Engineering Laboratory), NDE instrumentation development, universities, commercial NDE services and cable manufacturers, and Electric Power Research Institute (EPRI). The motivation for the R&D roadmap comes from the need to address the aging management of in-containment cables at nuclear power plants (NPPs).

  19. Fuel Pathway Integration Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The Fuel Pathway Integration Technical Team (FPITT) supports the U.S. DRIVE Partnership (the Partnership) in the identification and evaluation of implementation scenarios for fuel cell technology pathways, including hydrogen and fuel cell electric vehicles in the transportation sector, both during a transition period and in the long term.

  20. NASA Space Technology Draft Roadmap Area 13: Ground and Launch Systems Processing

    Science.gov (United States)

    Clements, Greg

    2011-01-01

    This slide presentation reviews the technology development roadmap for the area of ground and launch systems processing. The scope of this technology area includes: (1) Assembly, integration, and processing of the launch vehicle, spacecraft, and payload hardware (2) Supply chain management (3) Transportation of hardware to the launch site (4) Transportation to and operations at the launch pad (5) Launch processing infrastructure and its ability to support future operations (6) Range, personnel, and facility safety capabilities (7) Launch and landing weather (8) Environmental impact mitigations for ground and launch operations (9) Launch control center operations and infrastructure (10) Mission integration and planning (11) Mission training for both ground and flight crew personnel (12) Mission control center operations and infrastructure (13) Telemetry and command processing and archiving (14) Recovery operations for flight crews, flight hardware, and returned samples. This technology roadmap also identifies ground, launch and mission technologies that will: (1) Dramatically transform future space operations, with significant improvement in life-cycle costs (2) Improve the quality of life on earth, while exploring in co-existence with the environment (3) Increase reliability and mission availability using low/zero maintenance materials and systems, comprehensive capabilities to ascertain and forecast system health/configuration, data integration, and the use of advanced/expert software systems (4) Enhance methods to assess safety and mission risk posture, which would allow for timely and better decision making. Several key technologies are identified, with a couple of slides devoted to one of these technologies (i.e., corrosion detection and prevention). Development of these technologies can enhance life on earth and have a major impact on how we can access space, eventually making routine commercial space access and improve building and manufacturing, and weather

  1. A Roadmap for Strategic Development of Geothermal Exploration Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, Benjamin R. [SRA International Inc. and Geothermal Technologies Office, Washington, DC (United States); Ziagos, John [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Thorsteinsson, Hildigunnur [Geothermal Technologies Office, Washington, DC (United States); Hass, Eric [Geothermal Technologies Office, Golden, CO (United States)

    2013-02-13

    Characterizing productive geothermal systems is challenging yet critical to identify and develop an estimated 30 gigawatts electric (GWe) of undiscovered hydrothermal resources in the western U.S. This paper, undertaken by the U.S. Department of Energy’s Geothermal Technologies Office (GTO), summarizes needs and technical pathways that target the key geothermal signatures of temperature, permeability, and fluid content, and develops the time evolution of these pathways, tying in past and current GTO exploration Research and Development (R&D) projects. Beginning on a five-year timescale and projecting out to 2030, the paper assesses technologies that could accelerate the confirmation of 30 GWe. The resulting structure forms the basis for a Geothermal Exploration Technologies Roadmap, a strategic development plan to help guide GTO R&D investments that will lower the risk and cost of geothermal prospect identification. This roadmap is currently open for public comment. Send your comments to geothermal@ee.doe.gov.

  2. A roadmap to effective urban climate change adaptation

    Science.gov (United States)

    Setiadi, R.

    2018-03-01

    This paper outlines a roadmap to effective urban climate change adaptation built from our practical understanding of the evidence and effects of climate change and the preparation of climate change adaptation strategies and plans. This roadmap aims to drive research in achieving fruitful knowledge and solution-based achievable recommendations in adapting to climate change in urban areas with effective and systematic manner. This paper underscores the importance of the interplay between local government initiatives and a national government for effective adaptation to climate change and takes into account the policy process and politics. This paper argues that effective urban climate change adaptation has a contribution to build urban resilience and helps the achievement of national government goals and targets in climate change adaptation.

  3. Status report on roadmap headquarters issue resolution activities

    International Nuclear Information System (INIS)

    1993-01-01

    The Roadmap Project Office (RPO), under the Office of Planning (EM-14), continues to review headquarters (HQ) issues raised by the field in their roadmap documents. Currently, twenty-nine HQ issues are in the ''resolution'' process or are being defined for resolution. The resolution process involves an Environmental Restoration and Waste Management Program (EM) HQ person, the Action Officer (AO), as the leader in the resolution process. The RPO is responsible to EM-14 for reporting on the progress of issue resolution activities and also to provide contractor support to each Action Officer: the contractor support person is identifies as the Issue Resolution Facilitator (IF). Field contacts also are identified for each issue. This document provides current information on HQ issues actively in the ''resolution'' process or being defined for resolution. The issues are primarily institutional rather than technical and mainly involve regulatory, coordination, prioritization, policy and management concerns

  4. Mission Assurance Modeling and Simulation: A Cyber Security Roadmap

    Science.gov (United States)

    Gendron, Gerald; Roberts, David; Poole, Donold; Aquino, Anna

    2012-01-01

    This paper proposes a cyber security modeling and simulation roadmap to enhance mission assurance governance and establish risk reduction processes within constrained budgets. The term mission assurance stems from risk management work by Carnegie Mellon's Software Engineering Institute in the late 19905. By 2010, the Defense Information Systems Agency revised its cyber strategy and established the Program Executive Officer-Mission Assurance. This highlights a shift from simply protecting data to balancing risk and begins a necessary dialogue to establish a cyber security roadmap. The Military Operations Research Society has recommended a cyber community of practice, recognizing there are too few professionals having both cyber and analytic experience. The authors characterize the limited body of knowledge in this symbiotic relationship. This paper identifies operational and research requirements for mission assurance M&S supporting defense and homeland security. M&S techniques are needed for enterprise oversight of cyber investments, test and evaluation, policy, training, and analysis.

  5. SME UNIVERSITY COLLABORATION – A ROADMAP TO SUCCESS

    Directory of Open Access Journals (Sweden)

    Joe ENGLISH

    2013-11-01

    Full Text Available The paper presents the most important results on a methodology of collaboration between universities and SMEs. The SUPORT project examines the current knowledge and technology transfer scenarios between Small and Medium Sized Enterprises (SMEs and Higher Education Institutes (HEIs in six different regions of Europe (Ireland, UK, France, Germany, Poland and Spain. Based on these studies the project developed resources (roadmaps, training courses, on-line materials to enable SMEs to break down barriers and gain access to dormant research at HEIs. Universities are facilitated to find outlets for current and previous research, making them more responsive to current market needs. Based on these results the paper is indicated graphical roadmaps to guide participants in collaboration projects – one map specifically for HEI personnel and another for SMEs. These road maps are designed as ‘aides memoire’ for researchers and owner/managers as they embark upon, and deliver collaboration projects.

  6. Astroparticle physics in Europe gets a new roadmap

    CERN Multimedia

    Fabio Capello

    2011-01-01

    After publishing its first strategy plan in 2008, the AStroParticle European Research Area (ASPERA) – a network of European national funding agencies responsible for astroparticle physics – has just published an update. The new document provides an overview of the activities of the astroparticle physics community, makes recommendations for future projects and emphasizes the role of networking and sharing among the funding agencies.   The new strategies for Astroparticle Physics (ApP) – the research field at the intersection of astrophysics, particle physics and cosmology – were discussed at a meeting held in Paris on 21 and 22 November, when a new roadmap was presented to the community. “An update of the strategic plan published in 2008 was needed because of the significant progress made in recent years,” explains Arnaud Marsollier, ASPERA press officer. “In this new roadmap, ASPERA gives an updated overview of ApP Projects ...

  7. Technology Roadmaps: Carbon Capture and Storage in Industrial Applications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    A new technology roadmap on Carbon Capture and Storage in Industrial Applications, released today in Beijing, shows that carbon capture and storage (CCS) has the potential to reduce CO2 emissions from industrial applications by 4 gigatonnes in 2050. Such an amount is equal to roughly one-tenth of the total emission cuts needed from the energy sector by the middle of the century. This requires a rapid deployment of CCS technologies in various industrial sectors, and across both OECD and non-OECD countries. The roadmap, a joint report from the International Energy Agency (IEA) and the United Nations Industrial Development Organization (UNIDO), says that over 1800 industrial-scale projects are required over the next 40 years.

  8. The future of technology enhanced active learning – a roadmap

    OpenAIRE

    Pahl, Claus; Kenny, Claire

    2008-01-01

    The notion of active learning refers to the active involvement of learner in the learning process, capturing ideas of learning-by-doing and the fact that active participation and knowledge construction leads to deeper and more sustained learning. Interactivity, in particular learnercontent interaction, is a central aspect of technology-enhanced active learning. In this roadmap, the pedagogical background is discussed, the essential dimensions of technology-enhanced active learning syste...

  9. VERAM - Vision and Roadmap for European Raw Materials

    Science.gov (United States)

    Baumgarten, Wibke; Vashev, Boris

    2017-04-01

    The overall objective of VERAM project is to produce a Vision and Roadmap for European Raw Materials in 2050 based on raw materials research and innovation (R&I) coordination. Two leading European Technology Platforms (ETPs): ETP SMR (Sustainable Minerals Resources) and FTP (Forest Technology Platform) are joining forces to develop a common vison and roadmap with the support of ECTP (European Construction Technology Platform), represented by UNIVPM, SusChem (ETP for Sustainable Chemistry), represented by Cefic, EuMaT (Advanced Materials ETP), represented by VITO, ERAMIN 2, represented by Research Centre JUELICH and WoodWisdom Network Plus represented by the Agency for Renewable Resources (FNR). This partnership provides VERAM with expertise from downstream applications and additional knowledge on non-biotic and biotic raw materials. The project encourages capacity building as well as transfer of knowledge. It expects to provide an innovation reference point for the European Institute of Innovation & Technology (EIT) Raw Materials (formerly the KIC Raw MatTERS), to coordinate the network involved in the European Innovation Partnership (EIP) on Raw Materials Commitments and relevant proposals funded under Horizon 2020. It provides a platform for identifying gaps and complementarities and enables their bridging. VERAM will be able to advise the European Commission and Member States on future research needs and policies to stimulate innovation and assist in overcoming fragmentation in the implementing the EIP Raw Materials Strategic Implementation Plan. VERAM looks for mutually beneficial information exchange, encourages cross-fertilization between actions undertaken by different raw material industries, and expects to accelerate exploitation of breakthrough innovations. One of the main outcomes of the project is the presentation of a common long term 2050 Vision and Roadmap for relevant raw materials including metals, industrial minerals and aggregates and wood. The

  10. Codecharts roadmaps and blueprints for object-oriented programs

    CERN Document Server

    Eden, Amnon H

    2011-01-01

    NEW LANGUAGE VISUALIZES PROGRAM ABSTRACTIONS CLEARLY AND PRECISELY Popular software modelling notations visualize implementation minutiae but fail to scale, to capture design abstractions, and to deliver effective tool support. Tailored to overcome these limitations, Codecharts can elegantly model roadmaps and blueprints for Java, C++, and C# programs of any size clearly, precisely, and at any level of abstraction. More practically, significant productivity gains for programmers using tools supporting Codecharts have been demonstrated in controlled experiments. Hundreds of figures a

  11. Beyond the Crisis: A Roadmap for Reconciliation in Egypt

    OpenAIRE

    Houdaiby, Ibrahim el

    2014-01-01

    With the election of a new president, Egypt has reached another milestone in its roadmap for transition, but democracy and peace are still a long way off. The election of Abdul Fattah el-Sisi, former Minister of Defense, is likely to further complicate the country’s political crisis, since the Muslim Brotherhood holds him responsible for last year’s succession of massacres. Continued polarization fans political violence, impeding stability and much-needed economic growth. Changing the dynamic...

  12. Technology Roadmap for Energy Reduction in Automotive Manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2008-09-01

    U.S. Department of Energy’s (DOE) Industrial Technologies Program (ITP), in collaboration with the United States Council for Automotive Research LLC (USCAR), hosted a technology roadmap workshop in Troy, Michigan in May 2008. The purpose of the workshop was to explore opportunities for energy reduction, discuss the challenges and barriers that might need to be overcome, and identify priorities for future R&D. The results of the workshop are presented in this report.

  13. Nanotechnology for the Forest Products Industry Vision and Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Atalla, Rajai [USDA Forest Service, Washington, DC (United States); Beecher, James [USDA Forest Service, Washington, DC (United States); Caron, Robert [Technical Association of the Pulp and Paper Industry, Peachtree Corners, GA (United States); Catchmark, Jeffrey [Pennsylvania State Univ., State College, PA (United States); Deng, Yulin [Georgia Inst. of Technology, Atlanta, GA (United States); Glasser, Wolfgang [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Gray, Derek [McGill Univ., Montreal, QC (Canada); Haigler, Candace [North Carolina State Univ., Raleigh, NC (United States); Jones, Philip [Imerys, Paris (France); Joyce, Margaret [Western Michigan Univ., Kalamazoo MI (United States); Kohlman, Jane [USDA Forest Service, Washington, DC (United States); Koukoulas, Alexander [Technical Association of the Pulp and Paper Industry, Peachtree Corners, GA (United States); Lancaster, Peter [Weyerhaeuser Company, Longview, WA (United States); Perine, Lori [American Forest and Paper Association, Washington, DC (United States); Rodriguez, Augusto [Georgia-Pacific Corporation, Atlanta, GA (United States); Ragauskas, Arthur [Georgia Inst. of Technology, Atlanta, GA (United States); Wegner, Theodore [USDA Forest Service, Washington, DC (United States); Zhu, Junyong [USDA Forest Service, Washington, DC (United States)

    2005-03-01

    A roadmap for Nanotechnology in the Forest Products Industries has been developed under the umbrella of the Agenda 2020 program overseen by the CTO committee. It is expected that the use of new analytical techniques and methodologies will allow us to understand the complex nature of wood based materials and allow the dramatically enhanced use of the major strategic asset the US has in renewable, recyclable resources based on its well managed Forests.

  14. National Research Council Dialogue to Assess Progress on NASA's Systems Engineering Cost/Risk Analysis Capability Roadmap Development: General Background and Introduction

    Science.gov (United States)

    Regenie, Victoria

    2005-01-01

    Contents include the following: General Background and Introduction of Capability. Roadmaps for Systems Engineering Cost/Risk Analysis. Agency Objectives. Strategic Planning Transformation. Review Capability Roadmaps and Schedule. Review Purpose of NRC Review. Capability Roadmap Development (Progress to Date).

  15. Development of an Online Toolkit for Measuring Commercial Building Energy Efficiency Performance -- Scoping Study

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Na

    2013-03-13

    This study analyzes the market needs for building performance evaluation tools. It identifies the existing gaps and provides a roadmap for the U.S. Department of Energy (DOE) to develop a toolkit with which to optimize energy performance of a commercial building over its life cycle.

  16. Chemical Industry R&D Roadmap for Nanomaterials By Design. From Fundamentals to Function

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2003-12-01

    Vision2020 agreed to join NNI and the U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy (DOE/EERE) in sponsoring the "Nanomaterials and the Chemical Industry Roadmap Workshop" on September 30-October 2, 2002. This roadmap, Chemical Industry R&D Roadmap for Nanomaterials By Design: From Fundamentals to Function, is based on the scientific priorities expressed by workshop participants from the chemical industry, universities, and government laboratories.

  17. Technology roadmapping: The integration of strategic and technology planning for competitiveness

    Energy Technology Data Exchange (ETDEWEB)

    Bray, O.H.; Garcia, M.L.

    1997-04-01

    Technology roadmapping is a form of technology planning that can help organizations deal with an increasingly competitive environment. As a DOE laboratory with R&D as a major product, Sandia must do effective technology planning to identify and develop technologies required to meet its mission. Once technology enhancements or new technologies are identified, they may be developed internally or collaboratively with external partners. For either approach, technology roadmapping is an effective tool for technology planning and coordination, which fits within a broader set of planning activities. Potential benefits of roadmapping include identifying critical technologies and gaps, coordination of research activities, and improved marketing information. Roadmapping is particularly useful when investment decisions are not straightforward and for coordinating the development of multiple technologies, especially across multiple projects. This paper formalizes and documents the technology roadmapping process. It describes the process and shows how it fits within an overall strategic and technology planning process. The technology roadmapping process consists of three phases: preliminary activity, development of the roadmap, and followup activity. Preliminary activity includes: satisfy essential conditions, provide leadership/sponsorship, and define the scope and boundaries for the roadmap. Development of the technology roadmap includes: (1) Identify the {open_quotes}product{close_quotes} that will be the focus of the roadmap. (2) Identify the critical system requirements and their targets. (3) Specify the major technology areas. (4) Specify the technology drivers and their targets. (5) Identify technology alternatives and their time lines. (6) Recommend the technology alternatives that should be pursued. (7) Create the technology roadmap report. Follow-up activity includes: (1) Critique and validate the roadmap. (2) Develop an implementation plan. (3) Review and update.

  18. Technology Development Roadmap: A Technology Development Roadmap for a Future Gravitational Wave Mission

    Science.gov (United States)

    Camp, Jordan; Conklin, John; Livas, Jeffrey; Klipstein, William; McKenzie, Kirk; Mueller, Guido; Mueller, Juergen; Thorpe, James Ira; Arsenovic, Peter; Baker, John; hide

    2013-01-01

    Humankind will detect the first gravitational wave (GW) signals from the Universe in the current decade using ground-based detectors. But the richest trove of astrophysical information lies at lower frequencies in the spectrum only accessible from space. Signals are expected from merging massive black holes throughout cosmic history, from compact stellar remnants orbiting central galactic engines from thousands of close contact binary systems in the Milky Way, and possibly from exotic sources, some not yet imagined. These signals carry essential information not available from electromagnetic observations, and which can be extracted with extraordinary accuracy. For 20 years, NASA, the European Space Agency (ESA), and an international research community have put considerable effort into developing concepts and technologies for a GW mission. Both the 2000 and 2010 decadal surveys endorsed the science and mission concept of the Laser Interferometer Space Antenna (LISA). A partnership of the two agencies defined and analyzed the concept for a decade. The agencies partnered on LISA Pathfinder (LPF), and ESA-led technology demonstration mission, now preparing for a 2015 launch. Extensive technology development has been carried out on the ground. Currently, the evolved Laser Interferometer Space Antenna (eLISA) concept, a LISA-like concept with only two measurement arms, is competing for ESA's L2 opportunity. NASA's Astrophysics Division seeks to be a junior partner if eLISA is selected. If eLISA is not selected, then a LISA-like mission will be a strong contender in the 2020 decadal survey. This Technology Development Roadmap (TDR) builds on the LISA concept development, the LPF technology development, and the U.S. and European ground-based technology development. The eLISA architecture and the architecture of the Mid-sized Space-based Gravitational-wave Observatory (SGO Mid)-a competitive design with three measurement arms from the recent design study for a NASA

  19. Roadmapping - A Systematic Approach to Overcoming NGNP Challenges

    International Nuclear Information System (INIS)

    John W. Collins

    2008-01-01

    Changing requirements, programmatic challenges, and technical risk hinder even the best projects. The Next Generation Nuclear Plant (NGNP) is a complex project with technical and programmatic uncertainty. This paper presents the path forward, methods, and tools used to understand the requirements, manage the uncertainty, and mitigate the risk for the NGNP project. The key tool, technology development roadmaps, is described in detail as a means to facilitate NGNP risk-informed decision making, technology down selection, and technology qualification and maturation. Technology roadmaps for each NGNP System, Structure, or Component (SSC) were developed to set the vision for and drive the needed actions to down select technologies and designs; to assure technology readiness is demonstrated through testing, modeling, piloting, and prototyping; and to develop the test plans required to provide demonstrable evidence of the technology maturation required for codification and qualification. In the NGNP application, technology roadmaps provide the framework and structure required to systematically perform decision analysis, reduce risk, and mature technologies in a cost effective and timely manner. The steps followed include Structure Identification, Technology Readiness Assessment, Technology Selection, Technology Maturation, and Test Plan Development

  20. Infrastructures for systems medicine in Iran’s health roadmap

    Directory of Open Access Journals (Sweden)

    Iraj Nabipour

    2014-11-01

    Full Text Available Background: Systems medicine denotes a paradigm shift in medicine that arising from fundamental thoughts in systems biology. Systems medicine looks at health and disease using systems approaches. Systems or holistic approaches to studying the complexities of disease, emerging measurement and visualization molecular technologies to exploring of patient data space, and new computational and mathematical tools are fundamentals for this revolution in medicine. Methods: In order to explore the scientific/technological key objectives for systems medicine in “Iran’s Scientific Map in the Health Sector”, the details of goals, policies and requisites of Iran’s Health Roadmap were compared with horizontal and vertical policies of “National Institutes of Health (NIH Roadmap for Medical Research in U.S.A”. Results: A great attention has been paid on information technology, networking, interdisciplinary approach, innovation and high- risk research in Iran’s Health Roadmap. However, areas of research such as biological pathways (including metabolomics and networks structural biology molecular libraries and imaging bioinformatics and computational biology and human genome have not been adequately addressed. Conclusion: In order to react to waves of systems medicine, as a megatrend in health, Iran’s Scientific Map in the Health Sector should be synthesized to paradigm shift of emerging technologies in biomedicine. A framework for a broad interdisciplinary approach in biomedical research should be addressed to change medicine from reactive to proactive.

  1. A 21st century roadmap for human health risk assessment.

    Science.gov (United States)

    Pastoor, Timothy P; Bachman, Ammie N; Bell, David R; Cohen, Samuel M; Dellarco, Michael; Dewhurst, Ian C; Doe, John E; Doerrer, Nancy G; Embry, Michelle R; Hines, Ronald N; Moretto, Angelo; Phillips, Richard D; Rowlands, J Craig; Tanir, Jennifer Y; Wolf, Douglas C; Boobis, Alan R

    2014-08-01

    The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment, and involved over 120 participants from 12 countries, 15 government institutions, 20 universities, 2 non-governmental organizations, and 12 corporations. This paper provides a brief overview of the tiered RISK21 framework called the roadmap and risk visualization matrix, and articulates the core principles derived by RISK21 participants that guided its development. Subsequent papers describe the roadmap and matrix in greater detail. RISK21 principles include focusing on problem formulation, utilizing existing information, starting with exposure assessment (rather than toxicity), and using a tiered process for data development. Bringing estimates of exposure and toxicity together on a two-dimensional matrix provides a clear rendition of human safety and risk. The value of the roadmap is its capacity to chronicle the stepwise acquisition of scientific information and display it in a clear and concise fashion. Furthermore, the tiered approach and transparent display of information will contribute to greater efficiencies by calling for data only as needed (enough precision to make a decision), thus conserving animals and other resources.

  2. Incorporating the Technology Roadmap Uncertainties into the Project Risk Assessment

    International Nuclear Information System (INIS)

    Bonnema, B.E.

    2002-01-01

    This paper describes two methods, Technology Roadmapping and Project Risk Assessment, which were used to identify and manage the technical risks relating to the treatment of sodium bearing waste at the Idaho National Engineering and Environmental Laboratory. The waste treatment technology under consideration was Direct Vitrification. The primary objective of the Technology Roadmap is to identify technical data uncertainties for the technologies involved and to prioritize the testing or development studies to fill the data gaps. Similarly, project management's objective for a multi-million dollar construction project includes managing all the key risks in accordance to DOE O 413.3 - ''Program and Project Management for the Acquisition of Capital Assets.'' In the early stages, the Project Risk Assessment is based upon a qualitative analysis for each risk's probability and consequence. In order to clearly prioritize the work to resolve the technical issues identified in the Technology Roadmap, the issues must be cross- referenced to the project's Risk Assessment. This will enable the project to get the best value for the cost to mitigate the risks

  3. CASH 2021: Commercial access and space habitation

    Science.gov (United States)

    Aldrin, Andrew; Amara, Adam; Aris, Lodewijk; Baierl, Nida; Beatty, Patrick; Beaulieu, Catherine; Behnke, Torsten; Castegini, Roberta; Chauhan, Amitabh; Cojanis, Philip; Dayawansa, Pelawa; Diop, Marie; Eito, Kinya; Engle, Steve; Ferretti, Stefano; Gassama, Hamet; Genova, Bojana; Goulding, Colin; Janjua, Jameel; Jansaeng, Thidarat; Jousset, Frédéric; Kopik, Anatoly; Laurin, Catherine; Leggatt, Jason; Li, Hengnian; Mezzadri, Monica; Miura, Amane; Nolet, Simon; Ogami, Satoshi; Patry, Johanne; Patten, Laryssa; Payerne, Cyril; Peer, Guy; Prampolini, Marco; Rheaume, Caroline; Saary, Joan; Spehar, Daniela; Sufi, Atiya; Sun, Baosheng; Thompson, J. Barry; Thomson, Ward; Trautner, Roland; Tursunmuratov, Murat; Venet, Vrata; Wilems, Elizabeth; Wilson, Helen; Wittwer, Karl; Wokke, Frank; Wu, Yansheng; Zhou, Shaobin; Zilioli, Ilaria

    2002-07-01

    Issues about commercialization of space have been a growing concern in the past decade for the space community. This paper focuses on the work from a team of 51 students attending the Summer Session Program of the International Space University in Bremen, Germany. CASH 2021 (Commercial Access and Space Habitation) documents a plan that identifies commercial opportunities for space utilization that will extend human presence in space, and will chart the way forward for the next 20 years. The group selected four commercial sectors that show the most promise for the future: tourism, entertainment, space system service, assembly and debris removal, and research and development/production. The content of this document presents the results of their research. Historical activities in each of the commercial sectors are reviewed along with the current market situation. To provide a coherent background for future commercialization possibilities a scenario has been developed. This scenario includes a postulated upon ideal future and includes social, political and economic factors that may affect the space industry over the timeline of the study. The study also presents a roadmap, within the limited optimistic scenario developed, for the successful commercialization of space leading to future human presence in space. A broad range of commercially viable opportunities, not only within the current limits of the International Space Station, but also among the many new developments that are expected by 2021 are discussed.

  4. Growth of healthy and sanitizer-injured Salmonella cells on mung bean sprouts in different commercial enrichment broths.

    Science.gov (United States)

    Zheng, Qianwang; Mikš-Krajnik, Marta; D'Souza, Craig; Yang, Yishan; Heo, Da-Jeong; Kim, Si-Kyung; Lee, Seung-Cheol; Yuk, Hyun-Gyun

    2015-12-01

    The ability of nine commercial broths to enrich healthy and 90% sanitizer-injured Salmonella Typhimurium and Salmonella cocktail on mung bean sprouts was evaluated to select an optimum broth for detection. Results showed that S. Typhimurium multiplied faster and reached a higher population in buffered peptone water (BPW), Salmonella AD media (AD) and ONE broth-Salmonella (OB), compared with other broths. Healthy and 90% sanitizer-injured Salmonella at low concentrations increased by 4.0 log CFU/ml in these three broths. However, no Salmonella growth was observed in lactose broth (LB). Further investigation showed that during incubation, pH of LB dropped from 6.7 to 4.2, due to production of lactic (66 mM) and acetic acids (62 mM) by lactic acid bacteria that were identified as dominant microbiota in bean sprouts. Though no cell membrane damage was detected by propidium monoazide combined with real-time PCR, it was found that LB inhibited Salmonella growth, especially from low inoculum levels. This study suggests that in consideration of effectiveness and cost, BPW would be a suitable enrichment broth to use for isolating and detecting Salmonella on mung bean sprouts, while using LB might cause false negative results in Salmonella detection by either PCR or standard cultural method. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Commercialization scenarios of polymer electrolyte membrane fuel cell applications for stationary power generation in the United States by the year 2015

    Science.gov (United States)

    Millett, Stephen; Mahadevan, Kathya

    Battelle is identifying the most likely markets and economic impacts of stationary polymer electrolyte membrane (PEM) fuel cells in the range of 1-250 kW in the U.S. by the year 2015. For this task, Battelle is using the Interactive Future Simulations (IFS™), an analytical modeling and forecasting tool that uses expert judgment, trend analysis, and cross-impact analysis methods to generate most likely future conditions for PEM fuel cell applications, market acceptance, commercial viability, and economic impacts. The cross-impact model contains 28 descriptors including commercial and technological advances in both polymer electrolyte membrane (PEM) fuel cells and fossil fuel technologies, sources of hydrogen, investments, public policy, environmental regulation, value to consumers, commercialization leadership, modes of generation, and the reliability and prices of grid electricity. One likely scenario to the year 2015 is that the PEM fuel cells will be limited to commercial and industrial customers in the range of 50-200 kW with a market size less than US$ 5 billion a year.

  6. Roadmap grounded as 'visual portray' : Reflecting on an artifact and metaphor

    NARCIS (Netherlands)

    Simonse, W.L.; Buijs, J.A.; Hultink, H.J.

    2012-01-01

    Artifacts Design representations and presentations of work, strategic thinking, and business processes. Main theme Design!? - related by research program on Design Roadmapping, at the Industrial Design Engineering Faculty.

  7. Comparative Study of Surface Temperature Behavior of Commercial Li-Ion Pouch Cells of Different Chemistries and Capacities by Infrared Thermography

    Directory of Open Access Journals (Sweden)

    Shovon Goutam

    2015-08-01

    Full Text Available The non-uniform surface temperature distribution of a battery cell results from complex reactions inside the cell and makes efficient thermal management a challenging task. This experimental work attempts to determine the evolution of surface temperature distribution of three pouch type commercial cells: Nickel Manganese Cobalt oxide (NMC-based 20 Ah cell, Lithium Iron Phosphate (LFP 14 Ah, and Lithium Titanate Oxide (LTO 5 Ah battery cell by using contact thermistor and infrared (IR thermography. High current (up to 100 A continuous charge/discharge and high current (80 A micro pulse cycling profile were applied on the cells. It was found that thermistor based temperature profile varied cell to cell, especially the LTO cell. Among the investigated cells, the NMC cell shows highest temperature rise and the LTO cell the lowest rise. IR (Infrared images revealed the spatial distribution of surface temperature, in particular the location of the hottest region varies depending not only on the geometrical and material properties of the cell, but also the type of loads applied on the cells. Finally, a modeling perspective of the cell temperature non-uniformity is also discussed.

  8. Electricity Technology Roadmap. Technology for the Sustainable Society. 2025

    International Nuclear Information System (INIS)

    2002-01-01

    The Dutch Electricity Technology Roadmap Initiative is being developed by KEMA as a joint effort of Dutch and European experts of universities, industry and (non)governmental organisations. It aims to assess how to structure the ongoing collaborative research and technological advancement, the exploration of the opportunities and the threats for the electricity-based innovations over the next twenty-five years. In addition it analyses how to manage the transition towards a knowledge based economy and a more sustainable society. To date, about 100 organisations have participated with KEMA and its sponsors in shaping a comprehensive vision of the opportunities to structure the knowledge based economy in the Digital Society with as basis the increase of electricity's value to society. This vision is being translated into a set of technology development destinations and a total of six distinct initiatives for targeted projects. KEMA is leading this ongoing road-mapping effort, with the support of TENNET and EPRI (USA). The Dutch power generation utilities and the Ministry of Economics (EZ) financially support the work. It is an investment in the future of the Dutch knowledge based economy and a guidance to structure and strengthen the value of public and private RandD investments. The Electricity Technology Roadmap Initiative explores a period of fast regulatory, political, technological and institutional change in the electricity enterprise and in the society. The strategic choices made in this period of change can have profound consequences on whether future opportunities are opened or closed, and whether threats increase or are eliminated The reluctance to proceed with important changes is understandable, given the extreme uncertainty under which decisions must be made. No regrets solutions may be appropriate in some circumstances. These situations highlight the need for foresight and the importance of strategic roadmapping. The first year of the Roadmap

  9. The World Heart Federation Roadmap for Nonvalvular Atrial Fibrillation.

    Science.gov (United States)

    Murphy, Adrianna; Banerjee, Amitava; Breithardt, Günter; Camm, A John; Commerford, Patrick; Freedman, Ben; Gonzalez-Hermosillo, J Antonio; Halperin, Jonathan L; Lau, Chu-Pak; Perel, Pablo; Xavier, Denis; Wood, David; Jouven, Xavier; Morillo, Carlos A

    2017-12-01

    The World Heart Federation has undertaken an initiative to develop a series of Roadmaps to promote development of national policies and health systems approaches, and to identify potential roadblocks on the road to effective prevention, detection, and management of cardiovascular disease in low-and middle-income countries (LMICs) and develop strategies for overcoming these. This Roadmap focuses on atrial fibrillation (AF). AF is the most common, clinically significant arrhythmia and, among other clinical outcomes, is associated with increased risk of stroke. Development of this Roadmap included a review of published guidelines and research papers, and consultation with an expert committee comprising experts in clinical management of AF and health systems research in LMICs. The Roadmap identifies 1) key interventions for detection, diagnosis, and management of AF; 2) gaps in implementation of these interventions (knowledge-practice gaps); 3) health system roadblocks to implementation of AF interventions in LMICs; and 4) potential strategies for overcoming these. More research is needed on determinants and primary prevention of AF. Knowledge-practice gaps for detection, diagnosis, and management of AF are present worldwide, but may be more prominent in LMICs. Potential barriers to implementation of AF interventions include long distances to health facilities, shortage of health care professionals with training in AF, including interpretation of ECG, unaffordability of oral anticoagulants for patient households, reluctance on the part of physicians to initiate oral anticoagulant (OAC) therapy, and lack of awareness of the importance of persistent adherence to OAC therapy. Potential solutions include training of nonphysician health workers and pharmacists in pulse-taking, use of telemedicine technologies to transmit electrocardiogram results, engagement of nonphysician health workers in OAC therapy adherence support, and country-specific support and education programs

  10. Web-based Academic Roadmaps for Careers in the Geosciences

    Science.gov (United States)

    Murray, D. P.; Veeger, A. I.; Grossman-Garber, D.

    2007-12-01

    To a greater extent than most science programs, geology is underrepresented in K-12 curricula and the media. Thus potential majors have scant knowledge of academic requirements and career trajectories, and their idea of what geologists do--if they have one at all--is outdated. We have addressed these concerns by developing a dynamic, web-based academic roadmap for current and prospective students, their families, and others who are contemplating careers in the geosciences. The goals of this visually attractive "educational pathway" are to not only improve student recruitment and retention, but to empower student learning by creating better communication and advising tools that can render our undergraduate program transparent for learners and their families. Although we have developed academic roadmaps for four environmental and life science programs at the University of Rhode Island, we focus here on the roadmap for the geosciences, which illustrates educational pathways along the academic and early-career continuum for current and potential (i.e., high school) students who are considering the earth sciences. In essence, the Geosciences Academic Roadmap is a "one-stop'" portal to the discipline. It includes user- friendly information about our curriculum, outcomes (which at URI are tightly linked to performance in courses and the major), extracurricular activities (e.g., field camp, internships), careers, graduate programs, and training. In the presentation of this material extensive use is made of streaming video, interviews with students and earth scientists, and links to other relevant sites. Moreover, through the use of "Hot Topics", particular attention is made to insure that examples of geoscience activities are not only of relevance to today's students, but show geologists using the modern methods of the discipline in exciting ways. Although this is a "work-in-progress", evaluation of the sites, by high school through graduate students, has been strongly

  11. High power density superconducting rotating machines—development status and technology roadmap

    Science.gov (United States)

    Haran, Kiruba S.; Kalsi, Swarn; Arndt, Tabea; Karmaker, Haran; Badcock, Rod; Buckley, Bob; Haugan, Timothy; Izumi, Mitsuru; Loder, David; Bray, James W.; Masson, Philippe; Stautner, Ernst Wolfgang

    2017-12-01

    Superconducting technology applications in electric machines have long been pursued due to their significant advantages of higher efficiency and power density over conventional technology. However, in spite of many successful technology demonstrations, commercial adoption has been slow, presumably because the threshold for value versus cost and technology risk has not yet been crossed. One likely path for disruptive superconducting technology in commercial products could be in applications where its advantages become key enablers for systems which are not practical with conventional technology. To help systems engineers assess the viability of such future solutions, we present a technology roadmap for superconducting machines. The timeline considered was ten years to attain a Technology Readiness Level of 6+, with systems demonstrated in a relevant environment. Future projections, by definition, are based on the judgment of specialists, and can be subjective. Attempts have been made to obtain input from a broad set of organizations for an inclusive opinion. This document was generated through a series of teleconferences and in-person meetings, including meetings at the 2015 IEEE PES General meeting in Denver, CO, the 2015 ECCE in Montreal, Canada, and a final workshop in April 2016 at the University of Illinois, Urbana-Champaign that brought together a broad group of technical experts spanning the industry, government and academia.

  12. Avionics Collaborative Engineering Technology Delivery Order 0035: Secure Knowledge Management (SKM) Technology Research Roadmap - Technology Trends for Collaborative Information and Knowledge Management Research

    National Research Council Canada - National Science Library

    Moody, Russell

    2004-01-01

    ...) this SKM Technology Research Roadmap. The SKM Technology Research Roadmap provides information on the current state, trends, gaps, land research challenges associated with SKM technology research...

  13. Hydrogen delivery technology rRoadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2005-11-01

    Hydrogen holds the long-term potential to solve two critical problems related to the energy infrastructure: U.S. dependence on foreign oil and U.S. emissions of greenhouse gases and pollutants. The U.S. transportation sector is almost completely reliant on petroleum, over half of which is currently imported, and tailpipe emissions remain one of the country’s key air quality concerns. Fuel cell vehicles operating on hydrogen produced from domestically available resources – including renewable resources, coal with carbon sequestration, or nuclear energy – would dramatically decrease greenhouse gases and other emissions, and would reduce dependence on oil from politically volatile regions of the world. Clean, domestically-produced hydrogen could also be used to generate electricity in stationary fuel cells at power plants, further extending national energy and environmental benefits.

  14. Designing Program Roadmaps to Catalyze Community Formation: A Case Study of the Long-Term Stewardship Science and Technology Roadmapword

    International Nuclear Information System (INIS)

    Dixon, Brent; Hanson, Duane; Matthern, Gretchen

    2003-01-01

    A number of broad perspective technology roadmaps have been developed in the last few years as tools for coordinating nation-wide research in targeted areas. These roadmaps share a common characteristic of coalescing the associated stakeholder groups into a special-interest community that is willing to work cooperatively in achieving the roadmap goals. These communities are key to roadmap implementation as they provide the collaborative energy necessary to obtain the political support and funding required for identified science and technology development efforts. This paper discusses the relationship between roadmaps and special-interest communities, using the recently drafted Department of Energy's Long-Term Stewardship Science and Technology Roadmap as a case study. Specific aspects this roadmap's design facilitated the development of a long-term stewardship community while specific realities during roadmap development impacted the realization of the design

  15. Designing Program Roadmaps to Catalyze Community Formation: A Case Study of the Long-Term Stewardship Science and Technology Roadmapword

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, Brent; Hanson, Duane; Matthern, Gretchen

    2003-02-27

    A number of broad perspective technology roadmaps have been developed in the last few years as tools for coordinating nation-wide research in targeted areas. These roadmaps share a common characteristic of coalescing the associated stakeholder groups into a special-interest community that is willing to work cooperatively in achieving the roadmap goals. These communities are key to roadmap implementation as they provide the collaborative energy necessary to obtain the political support and funding required for identified science and technology development efforts. This paper discusses the relationship between roadmaps and special-interest communities, using the recently drafted Department of Energy's Long-Term Stewardship Science and Technology Roadmap as a case study. Specific aspects this roadmap's design facilitated the development of a long-term stewardship community while specific realities during roadmap development impacted the realization of the design.

  16. Enabling the Distributed Generation Market of High Temperature Fuel Cell and Absorption Chiller Systems to Support Critical and Commercial Loads

    Science.gov (United States)

    DiMola, Ashley M.

    Buildings account for over 18% of the world's anthropogenic Greenhouse Gas (GHG) emissions. As a result, a technology that can offset GHG emissions associated with buildings has the potential to save over 9 Giga-tons of GHG emissions per year. High temperature fuel cell and absorption chiller (HTFC/AC) technology offers a relatively low-carbon option for meeting cooling and electric loads for buildings while producing almost no criteria pollutants. GHG emissions in the state of California would decrease by 7.48 million metric tons per year if every commercial building in the State used HTFC/AC technology to meet its power and cooling requirements. In order to realize the benefits of HTFC/AC technology on a wide scale, the distributed generation market needs to be exposed to the technology and informed of its economic viability and real-world potential. This work characterizes the economics associated with HTFC/AC technology using select scenarios that are representative of realistic applications. The financial impacts of various input factors are evaluated and the HTFC/AC simulations are compared to the economics of traditional building utilities. It is shown that, in addition to the emissions reductions derived from the systems, HTFC/AC technology is financially preferable in all of the scenarios evaluated. This work also presents the design of a showcase environment, centered on a beta-test application, that presents (1) system operating data gathered using a custom data acquisition module, and (2) HTFC/AC technology in a clear and approachable manner in order to serve the target audience of market stakeholders.

  17. U.S. Army unmanned aircraft systems roadmap 2010-2035

    Science.gov (United States)

    2010-01-01

    The Unmanned Aircraft System (UAS) Roadmap outlines how the U.S. Army will develop, organize, and employ UAS from 2010 to 2035 across full spectrum operations. The Army UAS Roadmap is nested with the Unmanned Systems (UMS) Initial Capabilities Docume...

  18. NASA's New Thermal Management Systems Roadmap; Whats in it, What it Means

    Science.gov (United States)

    Swanson, Ted

    2016-01-01

    In July of 2015 NASA publically released a new set of Technology Area Roadmaps that will be used to help guide future NASA-funded technology development efforts. One of these was the Thermal Management Systems Roadmap, often identified as TA14. This Roadmap identifies the time sequencing and interdependencies of high priority, advanced thermal control technology for the next 5 to 20 years. Available funding limits the development of new technology. The Roadmaps are the first step in the process of prioritizing HQ-supported technology funding. The 2015 Roadmaps are focused on planned mission architectures and needs, as identified in the NRC-led science Decadals and HEOMD's Design Reference Missions. Additionally, the 2015 Roadmaps focus on "applied " R&D as opposed to more basic research. The NASA Mission Directorates were all closely involved in development of 2015 Roadmaps, and an extensive external review was also conducted. This talk will discuss the Technology Roadmaps in general, and then focus on the specific technologies identified for TA 14, Thermal Management Systems.

  19. Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systems

    DEFF Research Database (Denmark)

    Ferrari, Andrea C.; Bonaccorso, Francesco; Falko, Vladimir

    2015-01-01

    We present the science and technology roadmap (STR) for graphene, related twodimensional (2d) crystals, and hybrid systems, targeting an evolution in technology, that might lead to impacts and benefits reaching into most areas of society. The roadmap was developed within the framework of the Euro...

  20. Commercial Toilets

    Science.gov (United States)

    Whether you are looking to reduce water use in a new facility or replace old, inefficient toilets in commercial restrooms, a WaterSense labeled flushometer-valve toilet is a high-performance, water-efficient option worth considering.

  1. 76 FR 66040 - NIST Framework and Roadmap for Smart Grid Interoperability Standards, Release 2.0 (Draft...

    Science.gov (United States)

    2011-10-25

    ... National Institute of Standards and Technology NIST Framework and Roadmap for Smart Grid Interoperability... and Technology (NIST) seeks comments on the draft NIST Framework and Roadmap for Smart Grid..., 2011. The entire draft version of the NIST Framework and Roadmap for Smart Grid Interoperability...

  2. Idaho National Engineering Laboratory High-Level Waste Roadmap

    International Nuclear Information System (INIS)

    1993-08-01

    The Idaho National Engineering Laboratory (INEL) High-Level Waste (HLW) Roadmap takes a strategic look at the entire HLW life-cycle starting with generation, through interim storage, treatment and processing, transportation, and on to final disposal. The roadmap is an issue-based planning approach that compares ''where we are now'' to ''where we want and need to be.'' The INEL has been effectively managing HLW for the last 30 years. Calcining operations are continuing to turn liquid HLW into a more manageable form. Although this document recognizes problems concerning HLW at the INEL, there is no imminent risk to the public or environment. By analyzing the INEL current business operations, pertinent laws and regulations, and committed milestones, the INEL HLW Roadmap has identified eight key issues existing at the INEL that must be resolved in order to reach long-term objectives. These issues are as follows: A. The US Department of Energy (DOE) needs a consistent policy for HLW generation, handling, treatment, storage, and disposal. B. The capability for final disposal of HLW does not exist. C. Adequate processes have not been developed or implemented for immobilization and disposal of INEL HLW. D. HLW storage at the INEL is not adequate in terms of capacity and regulatory requirements. E. Waste streams are generated with limited consideration for waste minimization. F. HLW is not adequately characterized for disposal nor, in some cases, for storage. G. Research and development of all process options for INEL HLW treatment and disposal are not being adequately pursued due to resource limitations. H. HLW transportation methods are not selected or implemented. A root-cause analysis uncovered the underlying causes of each of these issues

  3. Roadmap to a tobacco epidemic: transnational tobacco companies invade Indonesia.

    Science.gov (United States)

    Hurt, Richard D; Ebbert, Jon O; Achadi, Anhari; Croghan, Ivana T

    2012-05-01

    Indonesia is the world's fifth largest cigarette market in the world but for decades, transnational tobacco companies (TTCs) have had limited success infiltrating this market, due to their inability to compete in the kretek market. Kreteks are clove/tobacco cigarettes that most Indonesians smoke. To determine how Phillip Morris International (PMI) and British American Tobacco (BAT) have now successfully achieved a substantial market presence in Indonesia. We analyzed previously secret, tobacco industry documents, corporate reports on Indonesia operations, the Tobacco Trade press, Indonesia media, and "The Roadmap". Internal, corporate documents from BAT and PMI demonstrate that they had known for decades that kreteks are highly carcinogenic. Despite that knowledge, BAT and PMI now own and heavily market these products, as well as new more westernised versions of kreteks. BAT and PMI used their successful basic strategy of keeping cigarettes affordable by maintaining the social responsibility of smoking and opposing smoke-free workplace laws but in the 21st century, they added the acquisition of and westernisation of domestic kretek manufacturers as an additional strategy. These acquisitions allowed them to assert influences on health policy in Indonesia and to grow their business under current government policy embodied in the 2007-2020 Roadmap of Tobacco Products Industry and Excise Policy which calls for increased cigarette production by 12% over the next 15 years. PMI and Bat have successfully entered and are expanding their share in the Indonesia cigarette market. Despite the obvious and pervasive influence of the tobacco industry on policy decisions, the Indonesian government should ratify the FCTC and implement effective legislation to reduce tobacco consumption and exposure to tobacco smoke and revise the Roadmap to protect future generations of Indonesians.

  4. Developing the "Lunar Vicinity" Scenario of the Global Exploration Roadmap

    Science.gov (United States)

    Schmidt, G.; Neal, C. R.; Crawford, I. A.; Ehrenfreund, P.

    2014-04-01

    The Global Exploration Roadmap (GER, [1]) has been developed by the International Space Exploration Coordination Group (ISECG - comprised of 14 space agencies) to define various pathways to getting humans beyond low Earth orbit and eventually to Mars. Such pathways include visiting asteroids or the Moon before going on to Mars. This document has been written at a very high level and many details are still to be determined. However, a number of important papers regarding international space exploration can form a basis for this document (e.g. [2,3]). In this presentation, we focus on developing the "Lunar Vicinity" scenario by adding detail via mapping a number of recent reports/documents into the GER. Precedence for this scenario is given by Szajnfarber et al. [4] who stated "We find that when international partners are considered endogenously, the argument for a "flexible path" approach is weakened substantially. This is because international contributions can make "Moon first" economically feasible". The documents highlighted here are in no way meant to be all encompassing and other documents can and should be added, (e.g., the JAXA Space Exploration Roadmap). This exercise is intended to demonstrate that existing documents can be mapped into the GER despite the major differences in granularity, and that this mapping is a way to promote broader national and international buy-in to the Lunar Vicinity scenario. The documents used here are: the Committee on Space Research (COSPAR) Panel on Exploration report on developing a global space exploration program [5], the Strategic Knowledge Gaps (SKGs) report from the Lunar Exploration Analysis Group (LEAG) [6], the Lunar Exploration Roadmap developed by LEAG [7], the National Research Council report Scientific Context for the Exploration of the Moon (SCEM) [8], the scientific rationale for resuming lunar surface exploration [9], the astrobiological benefits of human space exploration [9,10].

  5. Space Commercialization

    Science.gov (United States)

    Martin, Gary L.

    2011-01-01

    A robust and competitive commercial space sector is vital to continued progress in space. The United States is committed to encouraging and facilitating the growth of a U.S. commercial space sector that supports U.S. needs, is globally competitive, and advances U.S. leadership in the generation of new markets and innovation-driven entrepreneurship. Energize competitive domestic industries to participate in global markets and advance the development of: satellite manufacturing; satellite-based services; space launch; terrestrial applications; and increased entrepreneurship. Purchase and use commercial space capabilities and services to the maximum practical extent Actively explore the use of inventive, nontraditional arrangements for acquiring commercial space goods and services to meet United States Government requirements, including measures such as public-private partnerships, . Refrain from conducting United States Government space activities that preclude, discourage, or compete with U.S. commercial space activities. Pursue potential opportunities for transferring routine, operational space functions to the commercial space sector where beneficial and cost-effective.

  6. Mission to the Solar System: Exploration and Discovery. A Mission and Technology Roadmap

    Science.gov (United States)

    Gulkis, S. (Editor); Stetson, D. S. (Editor); Stofan, E. R. (Editor)

    1998-01-01

    Solar System exploration addresses some of humanity's most fundamental questions: How and when did life form on Earth? Does life exist elsewhere in the Solar System or in the Universe? - How did the Solar System form and evolve in time? - What can the other planets teach us about the Earth? This document describes a Mission and Technology Roadmap for addressing these and other fundamental Solar System Questions. A Roadmap Development Team of scientists, engineers, educators, and technologists worked to define the next evolutionary steps in in situ exploration, sample return, and completion of the overall Solar System survey. Guidelines were to "develop aa visionary, but affordable, mission and technology development Roadmap for the exploration of the Solar System in the 2000 to 2012 timeframe." The Roadmap provides a catalog of potential flight missions. (Supporting research and technology, ground-based observations, and laboratory research, which are no less important than flight missions, are not included in this Roadmap.)

  7. Building a roadmap for developing combination therapies for Alzheimer's disease.

    Science.gov (United States)

    Perry, Daniel; Sperling, Reisa; Katz, Russell; Berry, Donald; Dilts, David; Hanna, Debra; Salloway, Stephen; Trojanowski, John Q; Bountra, Chas; Krams, Michael; Luthman, Johan; Potkin, Steven; Gribkoff, Val; Temple, Robert; Wang, Yaning; Carrillo, Maria C; Stephenson, Diane; Snyder, Heather; Liu, Enchi; Ware, Tony; McKew, John; Fields, F Owen; Bain, Lisa J; Bens, Cynthia

    2015-03-01

    Combination therapy has proven to be an effective strategy for treating many of the world's most intractable diseases. A growing number of investigators in academia, industry, regulatory agencies, foundations and advocacy organizations are interested in pursuing a combination approach to treating Alzheimer's disease. A meeting co-hosted by the Accelerate Cure/Treatments for Alzheimer's Disease Coalition, the Critical Path Institute and the Alzheimer's Association addressed challenges in designing clinical trials to test multiple treatments in combination and outlined a roadmap for making such trials a reality.

  8. Roadmap to a Sustainable Structured Trusted Employee Program

    Energy Technology Data Exchange (ETDEWEB)

    Coates, Cameron W [ORNL; Eisele, Gerhard R [ORNL

    2013-08-01

    Organizations (facility, regulatory agency, or country) have a compelling interest in ensuring that individuals who occupy sensitive positions affording access to chemical biological, radiological and nuclear (CBRN) materials facilities and programs are functioning at their highest level of reliability. Human reliability and human performance relate not only to security but also focus on safety. Reliability has a logical and direct relationship to trustworthiness for the organization is placing trust in their employees to conduct themselves in a secure, safe, and dependable manner. This document focuses on providing an organization with a roadmap to implementing a successful and sustainable Structured Trusted Employee Program (STEP).

  9. Roadmap for annotating transposable elements in eukaryote genomes.

    Science.gov (United States)

    Permal, Emmanuelle; Flutre, Timothée; Quesneville, Hadi

    2012-01-01

    Current high-throughput techniques have made it feasible to sequence even the genomes of non-model organisms. However, the annotation process now represents a bottleneck to genome analysis, especially when dealing with transposable elements (TE). Combined approaches, using both de novo and knowledge-based methods to detect TEs, are likely to produce reasonably comprehensive and sensitive results. This chapter provides a roadmap for researchers involved in genome projects to address this issue. At each step of the TE annotation process, from the identification of TE families to the annotation of TE copies, we outline the tools and good practices to be used.

  10. Comparison of egg and high yielding MDCK cell-derived live attenuated influenza virus for commercial production of trivalent influenza vaccine: in vitro cell susceptibility and influenza virus replication kinetics in permissive and semi-permissive cells.

    Science.gov (United States)

    Hussain, Althaf I; Cordeiro, Melissa; Sevilla, Elizabeth; Liu, Jonathan

    2010-05-14

    Currently MedImmune manufactures cold-adapted (ca) live, attenuated influenza vaccine (LAIV) from specific-pathogen free (SPF) chicken eggs. Difficulties in production scale-up and potential exposure of chicken flocks to avian influenza viruses especially in the event of a pandemic influenza outbreak have prompted evaluation and development of alternative non-egg based influenza vaccine manufacturing technologies. As part of MedImmune's effort to develop the live attenuated influenza vaccine (LAIV) using cell culture production technologies we have investigated the use of high yielding, cloned MDCK cells as a substrate for vaccine production by assessing host range and virus replication of influenza virus produced from both SPF egg and MDCK cell production technologies. In addition to cloned MDCK cells the indicator cell lines used to evaluate the impact of producing LAIV in cells on host range and replication included two human cell lines: human lung carcinoma (A549) cells and human muco-epidermoid bronchiolar carcinoma (NCI H292) cells. The influenza viruses used to infect the indicators cell lines represented both the egg and cell culture manufacturing processes and included virus strains that composed the 2006-2007 influenza seasonal trivalent vaccine (A/New Caledonia/20/99 (H1N1), A/Wisconsin/67/05 (H3N2) and B/Malaysia/2506/04). Results from this study demonstrate remarkable similarity between influenza viruses representing the current commercial egg produced and developmental MDCK cell produced vaccine production platforms. MedImmune's high yielding cloned MDCK cells used for the cell culture based vaccine production were highly permissive to both egg and cell produced ca attenuated influenza viruses. Both the A549 and NCI H292 cells regardless of production system were less permissive to influenza A and B viruses than the MDCK cells. Irrespective of the indicator cell line used the replication properties were similar between egg and the cell produced

  11. Evaluation of commercial lithium-ion cells based on composite positive electrode for plug-in hybrid electric vehicle applications. Part I: Initial characterizations

    International Nuclear Information System (INIS)

    Dubarry, Matthieu; Truchot, Cyril; Cugnet, Mikael; Liaw, Bor Yann; Gering, Kevin; Sazhin, Sergiy; Jamison, David; Michelbacher, Christopher

    2011-01-01

    Evaluating commercial Li-ion batteries presents some unique benefits. One of them is to use cells made from established fabrication process and form factor, such as those offered by the 18650 cylindrical configuration, to provide a common platform to investigate and understand performance deficiency and aging mechanism of target chemistry. Such an approach shall afford us to derive relevant information without influence from processing or form factor variability that may skew our understanding on cell-level issues. A series of 1.9 Ah 18650 lithium ion cells developed by a commercial source using a composite positive electrode comprising (LiMn1/3Ni1/3Co1/3O2 + LiMn2O4) is being used as a platform for the investigation of certain key issues, particularly path-dependent aging and degradation in future plug-in hybrid electric vehicle (PHEV) applications, under the US Department of Energy's Applied Battery Research (ABR) program. Here we report in Part I the initial characterizations of the cell performance and Part II some aspects of cell degradation in 2C cycle aging. The initial characterizations, including cell-to-cell variability, are essential for life cycle performance characterization in the second part of the report when cell-aging phenomena are discussed. Due to the composite nature of the positive electrode, the features (or signature) derived from the incremental capacity (IC) of the cell appear rather complex. In this work, the method to index the observed IC peaks is discussed. Being able to index the IC signature in details is critical for analyzing and identifying degradation mechanism later in the cycle aging study.

  12. Adoption of Electronic Health Records: A Roadmap for India.

    Science.gov (United States)

    Srivastava, Sunil Kumar

    2016-10-01

    The objective of the study was to create a roadmap for the adoption of Electronic Health Record (EHR) in India based an analysis of the strategies of other countries and national scenarios of ICT use in India. The strategies for adoption of EHR in other countries were analyzed to find the crucial steps taken. Apart from reports collected from stakeholders in the country, the study relied on the experience of the author in handling several e-health projects. It was found that there are four major areas where the countries considered have made substantial efforts: ICT infrastructure, Policy & regulations, Standards & interoperability, and Research, development & education. A set of crucial activities were identified in each area. Based on the analysis, a roadmap is suggested. It includes the creation of a secure health network; health information exchange; and the use of open-source software, a national health policy, privacy laws, an agency for health IT standards, R&D, human resource development, etc. Although some steps have been initiated, several new steps need to be taken up for the successful adoption of EHR. It requires a coordinated effort from all the stakeholders.

  13. A Region-Based Strategy for Collaborative Roadmap Construction

    KAUST Repository

    Denny, Jory

    2015-01-01

    © Springer International Publishing Switzerland 2015. Motion planning has seen much attention over the past two decades. A great deal of progress has been made in sampling-based planning, whereby a planner builds an approximate representation of the planning space. While these planners have demonstrated success inmany scenarios, there are still difficult problems where they lack robustness or efficiency, e.g., certain types of narrow spaces. Conversely, human intuition can often determine an approximate solution to these problems quite effectively, but humans lack the speed and precision necessary to perform the corresponding low-level tasks (such as collision checking) in a timely manner. In this work, we introduce a novel strategy called Region Steering in which the user and a PRM planner work cooperatively to map the space while maintaining the probabilistic completeness property of the PRMplanner. Region Steering utilizes two-way communication to integrate the strengths of both the user and the planner, thereby overcoming the weaknesses inherent to relying on either one alone. In one communication direction, a user can input regions, or bounding volumes in the workspace, to bias sampling towards or away from these areas. In the other direction, the planner displays its progress to the user and colors the regions based on their perceived usefulness.We demonstrate that Region Steering provides roadmap customizability, reduced mapping time, and smaller roadmap sizes compared with fully automated PRMs, e.g., Gaussian PRM.

  14. Realizing the next generation of CPV cells using transfer printing

    Science.gov (United States)

    Lumb, Matthew P.; Schmieder, Kenneth J.; González, María; Mack, Shawn; Yakes, Michael K.; Meitl, Matthew; Burroughs, Scott; Ebert, Chris; Bennett, Mitchell F.; Forbes, David V.; Sheng, Xing; Rogers, John A.; Walters, Robert J.

    2015-09-01

    Transfer-printing is an important, commercial technology for manufacturing state of the art CPV modules, and has emerged recently as a key enabling technology for the realization of ultra-high-efficiency, mechanically stacked III-V solar cells with low cost. This paper presents the latest results for microscale CPV cells grown on GaAs, InP and GaSb substrates for ultra-high-efficiency, four-terminal, mechanically stacked architectures. The latest findings from a combination of modeling, growth, processing and characterization of single and multijunction solar cells are described, and the roadmap to the long-term goal of using transfer-printing to produce the first solar cell with 50% conversion efficiency is outlined.

  15. National cyber defense high performance computing and analysis : concepts, planning and roadmap.

    Energy Technology Data Exchange (ETDEWEB)

    Hamlet, Jason R.; Keliiaa, Curtis M.

    2010-09-01

    There is a national cyber dilemma that threatens the very fabric of government, commercial and private use operations worldwide. Much is written about 'what' the problem is, and though the basis for this paper is an assessment of the problem space, we target the 'how' solution space of the wide-area national information infrastructure through the advancement of science, technology, evaluation and analysis with actionable results intended to produce a more secure national information infrastructure and a comprehensive national cyber defense capability. This cybersecurity High Performance Computing (HPC) analysis concepts, planning and roadmap activity was conducted as an assessment of cybersecurity analysis as a fertile area of research and investment for high value cybersecurity wide-area solutions. This report and a related SAND2010-4765 Assessment of Current Cybersecurity Practices in the Public Domain: Cyber Indications and Warnings Domain report are intended to provoke discussion throughout a broad audience about developing a cohesive HPC centric solution to wide-area cybersecurity problems.

  16. Space life and biomedical sciences in support of the global exploration roadmap and societal development

    Science.gov (United States)

    Evetts, S. N.

    2014-08-01

    The human exploration of space is pushing the boundaries of what is technically feasible. The space industry is preparing for the New Space era, the momentum for which will emanate from the commercial human spaceflight sector, and will be buttressed by international solar system exploration endeavours. With many distinctive technical challenges to be overcome, human spaceflight requires that numerous biological and physical systems be examined under exceptional circumstances for progress to be made. To effectively tackle such an undertaking significant intra- and international coordination and collaboration is required. Space life and biomedical science research and development (R & D) will support the Global Exploration Roadmap (GER) by enabling humans to 'endure' the extreme activity that is long duration human spaceflight. In so doing the field will discover solutions to some of our most difficult human health issues, and as a consequence benefit society as a whole. This space-specific R&D will drive a significant amount of terrestrial biomedical research and as a result the international community will not only gain benefits in the form of improved healthcare in space and on Earth, but also through the growth of its science base and industry.

  17. A roadmap for the synthesis of separation networks for the recovery of bio-based chemicals: Matching biological and process feasibility.

    Science.gov (United States)

    Yenkie, Kirti M; Wu, WenZhao; Clark, Ryan L; Pfleger, Brian F; Root, Thatcher W; Maravelias, Christos T

    2016-12-01

    Microbial conversion of renewable feedstocks to high-value chemicals is an attractive alternative to current petrochemical processes because it offers the potential to reduce net CO 2 emissions and integrate with bioremediation objectives. Microbes have been genetically engineered to produce a growing number of high-value chemicals in sufficient titer, rate, and yield from renewable feedstocks. However, high-yield bioconversion is only one aspect of an economically viable process. Separation of biologically synthesized chemicals from process streams is a major challenge that can contribute to >70% of the total production costs. Thus, process feasibility is dependent upon the efficient selection of separation technologies. This selection is dependent on upstream processing or biological parameters, such as microbial species, product titer and yield, and localization. Our goal is to present a roadmap for selection of appropriate technologies and generation of separation schemes for efficient recovery of bio-based chemicals by utilizing information from upstream processing, separation science and commercial requirements. To achieve this, we use a separation system comprising of three stages: (I) cell and product isolation, (II) product concentration, and (III) product purification and refinement. In each stage, we review the technology alternatives available for different tasks in terms of separation principles, important operating conditions, performance parameters, advantages and disadvantages. We generate separation schemes based on product localization and its solubility in water, the two most distinguishing properties. Subsequently, we present ideas for simplification of these schemes based on additional properties, such as physical state, density, volatility, and intended use. This simplification selectively narrows down the technology options and can be used for systematic process synthesis and optimal recovery of bio-based chemicals. Copyright © 2016 Elsevier

  18. PVT roadmap. A European guide for the development and market introduction of PVT technology

    Energy Technology Data Exchange (ETDEWEB)

    Zondag, H.A.; Van Helden, W.G.J.; Bakker, M. [ECN Renewable Energy in the Built Environment DEGO, Petten (Netherlands); Affolter, P. [Solstis, Lausanne (Switzerland); Eisenmann, W. [Institut fuer Solarenergieforschung ISFH, Emmerthal (Germany); Fechner, H. [Arsenal Research, Vienna (Austria); Rommel, M. [Fraunhofer ISE, Freiburg (Germany); Schaap, A. [Ecofys, Utrecht (Netherlands); Soerensen, H. [Esbensen, Copenhagen (Denmark); Tripanagnostopoulos, Y. [University of Patras, Patras (Greece)

    2006-06-15

    The aim of the roadmap is to identify promising markets for PVT (PhotoVoltaic Thermal) technology , and to identify the economical, policy, legislative and technical bottlenecks. In addition, the roadmap wants to inform the parties in the market on PVT. It thereby targets a broad range of professionals, including policy makers, solar manufacturers, installers and researchers. This work has been carried out within the PVT forum project, which is part of the EU-supported project PV-Catapult. The aim of PVT Forum is to lay the foundations for a large-scale introduction of PVT technology in Europe by means of this roadmap. In order to construct the roadmap, a two-step approach was taken. As a first step, PVT experts, PV and solar thermal industries and other stakeholders were brought together in two workshops, connected to the PVSEC 2004 in Paris and the Eurosun conference 2004 in Freiburg, to identify drivers and barriers for PVT. The results of these two workshops, that were presented in two workshop reports, were used as input for the roadmap presented here. As a second step, the PVT roadmap was written, formulating the necessary actions that should be taken on short, medium and long term in order to enlarge the market for PVT products. The chapters of the roadmap are written and reviewed by the various participants in PVT Forum. These participants have been selected for this project on the basis of their contribution to PVT development over the last years.

  19. PVT roadmap. A European guide for the development and market introduction of PVT technology

    International Nuclear Information System (INIS)

    Zondag, H.A.; Van Helden, W.G.J.; Bakker, M.; Affolter, P.; Eisenmann, W.; Fechner, H.; Rommel, M.; Schaap, A.; Soerensen, H.; Tripanagnostopoulos, Y.

    2006-06-01

    The aim of the roadmap is to identify promising markets for PVT (PhotoVoltaic Thermal) technology , and to identify the economical, policy, legislative and technical bottlenecks. In addition, the roadmap wants to inform the parties in the market on PVT. It thereby targets a broad range of professionals, including policy makers, solar manufacturers, installers and researchers. This work has been carried out within the PVT forum project, which is part of the EU-supported project PV-Catapult. The aim of PVT Forum is to lay the foundations for a large-scale introduction of PVT technology in Europe by means of this roadmap. In order to construct the roadmap, a two-step approach was taken. As a first step, PVT experts, PV and solar thermal industries and other stakeholders were brought together in two workshops, connected to the PVSEC 2004 in Paris and the Eurosun conference 2004 in Freiburg, to identify drivers and barriers for PVT. The results of these two workshops, that were presented in two workshop reports, were used as input for the roadmap presented here. As a second step, the PVT roadmap was written, formulating the necessary actions that should be taken on short, medium and long term in order to enlarge the market for PVT products. The chapters of the roadmap are written and reviewed by the various participants in PVT Forum. These participants have been selected for this project on the basis of their contribution to PVT development over the last years

  20. Advanced Accelerator Development Strategy Report: DOE Advanced Accelerator Concepts Research Roadmap Workshop

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-02-03

    Over a full two day period, February 2–3, 2016, the Office of High Energy Physics convened a workshop in Gaithersburg, MD to seek community input on development of an Advanced Accelerator Concepts (AAC) research roadmap. The workshop was in response to a recommendation by the HEPAP Accelerator R&D Subpanel [1] [2] to “convene the university and laboratory proponents of advanced acceleration concepts to develop R&D roadmaps with a series of milestones and common down selection criteria towards the goal for constructing a multi-TeV e+e– collider” (the charge to the workshop can be found in Appendix A). During the workshop, proponents of laser-driven plasma wakefield acceleration (LWFA), particle-beam-driven plasma wakefield acceleration (PWFA), and dielectric wakefield acceleration (DWFA), along with a limited number of invited university and laboratory experts, presented and critically discussed individual concept roadmaps. The roadmap workshop was preceded by several preparatory workshops. The first day of the workshop featured presentation of three initial individual roadmaps with ample time for discussion. The individual roadmaps covered a time period extending until roughly 2040, with the end date assumed to be roughly appropriate for initial operation of a multi-TeV e+e– collider. The second day of the workshop comprised talks on synergies between the roadmaps and with global efforts, potential early applications, diagnostics needs, simulation needs, and beam issues and challenges related to a collider. During the last half of the day the roadmaps were revisited but with emphasis on the next five to ten years (as specifically requested in the charge) and on common challenges. The workshop concluded with critical and unanimous endorsement of the individual roadmaps and an extended discussion on the characteristics of the common challenges. (For the agenda and list of participants see Appendix B.)

  1. Gas explosions and thermal runaways during external heating abuse of commercial lithium-ion graphite-LiCoO2 cells at different levels of ageing

    Science.gov (United States)

    Larsson, Fredrik; Bertilsson, Simon; Furlani, Maurizio; Albinsson, Ingvar; Mellander, Bengt-Erik

    2018-01-01

    Commercial 6.8 Ah lithium-ion cells with different ageing/status have been abused by external heating in an oven. Prior to the abuse test, selected cells were aged either by C/2 cycling up to 300 cycles or stored at 60 °C. Gas emissions were measured by FTIR and three separate vents were identified, two well before the thermal runaway while the third occurred simultaneously with the thermal runaway releasing heavy smoke and gas. Emissions of toxic carbon monoxide (CO), hydrogen fluoride (HF) and phosphorous oxyfluoride (POF3) were detected in the third vent, regardless if there was a fire or not. All abused cells went into thermal runaway and emitted smoke and gas, the working cells also released flames as well as sparks. The dead cells were however less reactive but still underwent thermal runaway. For about half of the working cells, for all levels of cycle ageing, ignition of the accumulated battery released gases occurred about 15 s after the thermal runaway resulting in a gas explosion. The thermal runaway temperature, about 190 °C, varied somewhat for the different cell ageing/status where a weak local minimum was found for cells cycled between 100 and 200 times.

  2. Electrochemistry of the Zinc-Silver Oxide System. Part 2: Practical Measurements of Energy Conversion Using Commercial Miniature Cells.

    Science.gov (United States)

    Smith, Michael J.; Vincent, Colin A.

    1989-01-01

    Summarizes the quantitative relationships pertaining to the operation of electrochemical cells. Energy conversion efficiency, cycle efficiency, battery power, and energy/power density of two types of zinc-silver oxide cells are discussed. (YP)

  3. A Governance Roadmap and Framework for EarthCube

    Science.gov (United States)

    Governance Steering Committee, EarthCube

    2013-04-01

    EarthCube is a process and an outcome, established to transform the conduct of research through the development of community-guided cyberinfrastructure for the Geosciences as the prototype for potential deployment across all domain sciences. EarthCube aims to create a knowledge management system and infrastructure that integrates all Earth system and human dimensions data in an open transparent, and inclusive manner. EarthCube requires broad community participation in concept, framework, and implementation and must not be hindered by rigid preconceptions. We discovered widely varying interpretations, expectations, and assumptions about governance among EarthCube participants. Our definition of governance refers to the processes, structure and organizational elements that determine, within an organization or system of organizations, how power is exercised, how stakeholders have their say, how decisions are made, and how decision makers are held accountable. We have learned, from historic infrastructure case studies, background research on governance and from community feedback during this roadmap process, that other types of large-scale, complex infrastructures, including the Internet, have no central control, administration, or management. No national infrastructure that we examined is governed by a single entity, let alone a single governance archetype. Thus we feel the roadmap process must accommodate a governance system or system of systems that may have a single governing entity, particularly at the start, but can evolve into a collective of governing bodies as warranted, in order to be successful. A fast-track process during Spring, 2012 culminated in a Governance Roadmap delivered to an NSF-sponsored charrette in June with an aggressive timetable to define and implement a governance structure to enable the elements of EarthCube to become operational expeditiously. Our goal is to help ensure the realization of this infrastructure sooner, more efficiently, and

  4. A Governance Roadmap and Framework for EarthCube

    Science.gov (United States)

    Allison, M. L.

    2012-12-01

    EarthCube is a process and an outcome, established to transform the conduct of research through the development of community-guided cyberinfrastructure for the Geosciences as the prototype for potential deployment across all domain sciences. EarthCube aims to create a knowledge management system and infrastructure that integrates all Earth system and human dimensions data in an open transparent, and inclusive manner. EarthCube requires broad community participation in concept, framework, and implementation and must not be hindered by rigid preconceptions. We discovered widely varying interpretations, expectations, and assumptions about governance among EarthCube participants. Our definition of governance refers to the processes, structure and organizational elements that determine, within an organization or system of organizations, how power is exercised, how stakeholders have their say, how decisions are made, and how decision makers are held accountable. We have learned, from historic infrastructure case studies, background research on governance and from community feedback during this roadmap process, that other types of large-scale, complex infrastructures, including the Internet, have no central control, administration, or management. No national infrastructure that we examined is governed by a single entity, let alone a single governance archetype. Thus we feel the roadmap process must accommodate a governance system or system of systems that may have a single governing entity, particularly at the start, but can evolve into a collective of governing bodies as warranted, in order to be successful. A fast-track process during Spring, 2012 culminated in a Governance Roadmap delivered to an NSF-sponsored charrette in June with an aggressive timetable to define and implement a governance structure to enable the elements of EarthCube to become operational expeditiously. Our goal is to help ensure the realization of this infrastructure sooner, more efficiently, and

  5. From vision to action: roadmapping as a strategic method and tool to implement climate change adaptation - the example of the roadmap 'water sensitive urban design 2020'.

    Science.gov (United States)

    Hasse, J U; Weingaertner, D E

    2016-01-01

    As the central product of the BMBF-KLIMZUG-funded Joint Network and Research Project (JNRP) 'dynaklim - Dynamic adaptation of regional planning and development processes to the effects of climate change in the Emscher-Lippe region (North Rhine Westphalia, Germany)', the Roadmap 2020 'Regional Climate Adaptation' has been developed by the various regional stakeholders and institutions containing specific regional scenarios, strategies and adaptation measures applicable throughout the region. This paper presents the method, elements and main results of this regional roadmap process by using the example of the thematic sub-roadmap 'Water Sensitive Urban Design 2020'. With a focus on the process support tool 'KlimaFLEX', one of the main adaptation measures of the WSUD 2020 roadmap, typical challenges for integrated climate change adaptation like scattered knowledge, knowledge gaps and divided responsibilities but also potential solutions and promising chances for urban development and urban water management are discussed. With the roadmap and the related tool, the relevant stakeholders of the Emscher-Lippe region have jointly developed important prerequisites to integrate their knowledge, to clarify vulnerabilities, adaptation goals, responsibilities and interests, and to foresightedly coordinate measures, resources, priorities and schedules for an efficient joint urban planning, well-grounded decision-making in times of continued uncertainties and step-by-step implementation of adaptation measures from now on.

  6. The very large research infrastructures: the French road-map

    International Nuclear Information System (INIS)

    2008-01-01

    After having recalled that the notion of TGIR (Tres Grande Infrastructure de Recherche, Very large research infrastructure) has evolved in time and now encompasses many different realities in terms of domain or size, this document briefly presents the main challenging fields of research: the planet, the universe seen from the Earth, particles and nuclei, matter, information, communication, computing and data services, human and social sciences, life sciences and health. It indicates TGIRs which have been selected for the French road-map: some already exist and operational (46), some are not yet operational but have been decided in terms of financing (19) and some are still projected but with different levels of priority. Appendices give selection criteria, working group compositions for different domains, and description sheets for these TGIRs (nature, localisation, scientific tools, spin-offs and impacts, international value, concerned scientific community, budget)

  7. The European Hematology Association Roadmap for European Hematology Research

    DEFF Research Database (Denmark)

    Engert, Andreas; Balduini, Carlo; Brand, Anneke

    2016-01-01

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology...... research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness...... of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology...

  8. Roadmap NRK 2012-2030; Routekaart NRK 2012-2030

    Energy Technology Data Exchange (ETDEWEB)

    Krebbekx, J.; Duivenvoorde, G.; De Wolf, W. [Berenschot Groep, Utrecht (Netherlands); Lenselink, J. [Energy Experts International, Huissen (Netherlands)

    2012-01-15

    This roadmap identifies how RKI companies (rubber and synthetic materials) can create new revenue opportunities: development of sustainable products, switching from petroleum to carbon chains from biobased materials, closing the material chain (reuse/recycling). Also within their own organizations more efficiency can be achieved by continuing to invest in innovation in processes and innovation in the organization itself. A selective overview is given of innovation projects [Dutch] In deze routekaart wordt aangegeven op welke wijze RKI-bedrijven (rubber en kunststoffen) nieuwe omzetkansen kunnen creeren: ontwikkelen van duurzame producten; overschakelen van aardolie naar koolstofketens uit biobased materialen; sluiten van de materiaalketen (hergebruik/recycling). Ook binnen de eigen organisatie kan er meer rendement worden behaald door te blijven investeren in innovatie in de eigen processen en innovatie in de eigen organisatie. Er is een overzicht gegeven van alle mogelijke verzamelde en geselecteerde innovatieprojecten.

  9. Open innovation in early drug discovery: roadmaps and roadblocks.

    Science.gov (United States)

    Reichman, Melvin; Simpson, Peter B

    2016-05-01

    Open innovation in pharmaceutical R&D evolved from a triple helix of convergent paradigm shifts in academic, industrial and government research sectors. The birth of the biotechnology sector catalyzed shifts in location dynamics that led to the first wave of open innovation in pharmaceutical R&D between big pharma and startup companies. The National Institutes of Health (NIH) Roadmap was a crucial inflection point that set the stage for a new wave of open innovation models between pharmaceutical companies and universities that have the potential to transform the pharmaceutical R&D landscape. We highlight the attributes of leading protected open innovation models that foster the sharing of proprietary small molecule collections by lowering the risk of premature escape of intellectual property, particularly structure-activity data. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Roadmap for biofertilizer development project at Malaysian Nuclear Agency

    International Nuclear Information System (INIS)

    Khairuddin Abdul Rahim; Ahmad Nazrul Abd Wahid; Phua Choo Kwai Hoe; Pauline Liew Woan Ying; Ahamad Sahali Mardi; Mat Rasol Awang

    2007-01-01

    This paper discusses the roadmap for the Biofertilizer Development Project conducted at the Malaysian Nuclear Agency (Nuclear Malaysia). The project started in 2003 and scheduled to end in 2008. Biofertilizer refers to living microorganisms or materials that contain living microorganisms that contributes to improvement in plant nutrition, soil fertility and crop productivity. The main components of the project are (a) biofertilizer substrate or carrier development, (b) biofertilizer inoculum development based on local indigenous microorganisms (c) biofertilizer product formulation and innovation, and (d) evaluation of efficiency of biofertilizer products on crops under different cropping systems, including under modern agriculture under soilless system. The above components may involve nuclear technology, viz, use of ionising radiation and the use of isotopic tracers. The paper also discusses local and international linkages, including with Forum for Nuclear Cooperation in Asia (FNCA) and the industry, and aspects of commercialisation and technology transfer. (Author)

  11. Roadmap toward addressing and communicating uncertainty in LCA

    DEFF Research Database (Denmark)

    Laurin, Lise; Vigon, Bruce; Fantke, Peter

    2017-01-01

    considerable uncertainty and variability at different assessment phases. These contributions have led to questions about the ability of LCA results to be used in decision-making. Mainly, variability is related to spatiotemporal, technological, and interspecies and inter-individual differences, while......Life Cycle Assessment (LCA) models for quantifying emissions and resources used as part of the life cycle inventory (LCI) step and for characterizing related impacts on human health, ecosystem quality, and natural resources as part of the life cycle impact assessment (LCIA) step together contribute......, model uncertainty, and uncertainty related to choices and human errors. As part of the LCA Capability Roadmap, a committee of nearly 40 contributors under the auspices of the SETAC North America LCA Interest Group is currently working to identify research needs in the area of ill...

  12. Used fuel extended storage security and safeguards by design roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Durbin, Samuel G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lindgren, Eric Richard [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Robert [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Ketusky, Edward [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); England, Jeffrey [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Scherer, Carolynn [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sprinkle, James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Miller, Michael. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rauch, Eric [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Scaglione, John [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dunn, T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-05-01

    In the United States, spent nuclear fuel (SNF) is safely and securely stored in spent fuel pools and dry storage casks. The available capacity in spent fuel pools across the nuclear fleet has nearly reached a steady state value. The excess SNF continues to be loaded in dry storage casks. Fuel is expected to remain in dry storage for periods beyond the initial dry cask certification period of 20 years. Recent licensing renewals have approved an additional 40 years. This report identifies the current requirements and evaluation techniques associated with the safeguards and security of SNF dry cask storage. A set of knowledge gaps is identified in the current approaches. Finally, this roadmap identifies known knowledge gaps and provides a research path to deliver the tools and models needed to close the gaps and allow the optimization of the security and safeguards approaches for an interim spent fuel facility over the lifetime of the storage site.

  13. Roadmap for Agriculture Biomass Feedstock Supply in the United States

    Energy Technology Data Exchange (ETDEWEB)

    J. Richard Hess; Thomas D. Foust; Reed Hoskinson; David Thompson

    2003-11-01

    The Biomass Research and Development Technical Advisory Committee established a goal that biomass will supply 5% of the nation’s power, 20% of its transportation fuels, and 25% of its chemicals by 2030. These combined goals are approximately equivalent to 30% of the country’s current petroleum consumption. The benefits of a robust biorefinery industry supplying this amount of domestically produced power, fuels, and products are considerable, including decreased demand for imported oil, revenue to the depressed agricultural industry, and revitalized rural economies. A consistent supply of highquality, low-cost feedstock is vital to achieving this goal. This biomass roadmap defines the research and development (R&D) path to supplying the feedstock needs of the biorefinery and to achieving the important national goals set for biomass. To meet these goals, the biorefinery industry must be more sustainable than the systems it will replace. Sustainability hinges on the economic profitability of all participants, on environmental impact of every step in the process, and on social impact of the product and its production. In early 2003, a series of colloquies were held to define and prioritize the R&D needs for supplying feedstock to the biorefinery in a sustainable manner. These colloquies involved participants and stakeholders in the feedstock supply chain, including growers, transporters, equipment manufacturers, and processors as well as environmental groups and others with a vested interest in ensuring the sustainability of the biorefinery. From this series of colloquies, four high-level strategic goals were set for the feedstock area: • Biomass Availability – By 2030, 1 billion dry tons of lignocellulosic feedstock is needed annually to achieve the power, fuel, and chemical production goals set by the Biomass Research and Development Technology Advisory Production Committee • Sustainability – Production and use of the 1 billion dry tons annually must be

  14. Ground-based Nuclear Detonation Detection (GNDD) Technology Roadmap

    International Nuclear Information System (INIS)

    Casey, Leslie A.

    2014-01-01

    This GNDD Technology Roadmap is intended to provide guidance to potential researchers and help management define research priorities to achieve technology advancements for ground-based nuclear explosion monitoring science being pursued by the Ground-based Nuclear Detonation Detection (GNDD) Team within the Office of Nuclear Detonation Detection in the National Nuclear Security Administration (NNSA) of the U.S. Department of Energy (DOE). Four science-based elements were selected to encompass the entire scope of nuclear monitoring research and development (R&D) necessary to facilitate breakthrough scientific results, as well as deliver impactful products. Promising future R&D is delineated including dual use associated with the Comprehensive Nuclear-Test-Ban Treaty (CTBT). Important research themes as well as associated metrics are identified along with a progression of accomplishments, represented by a selected bibliography, that are precursors to major improvements to nuclear explosion monitoring.

  15. Ground-based Nuclear Detonation Detection (GNDD) Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Casey, Leslie A.

    2014-01-13

    This GNDD Technology Roadmap is intended to provide guidance to potential researchers and help management define research priorities to achieve technology advancements for ground-based nuclear explosion monitoring science being pursued by the Ground-based Nuclear Detonation Detection (GNDD) Team within the Office of Nuclear Detonation Detection in the National Nuclear Security Administration (NNSA) of the U.S. Department of Energy (DOE). Four science-based elements were selected to encompass the entire scope of nuclear monitoring research and development (R&D) necessary to facilitate breakthrough scientific results, as well as deliver impactful products. Promising future R&D is delineated including dual use associated with the Comprehensive Nuclear-Test-Ban Treaty (CTBT). Important research themes as well as associated metrics are identified along with a progression of accomplishments, represented by a selected bibliography, that are precursors to major improvements to nuclear explosion monitoring.

  16. Venus Exploration opportunities within NASA's Solar System Exploration roadmap

    Science.gov (United States)

    Balint, Tibor; Thompson, Thomas; Cutts, James; Robinson, James

    2006-01-01

    Science goals to understand the origin, history and environment of Venus have been driving international space exploration missions for over 40 years. Past missions include the Magellan and Pioneer-Venus missions by the US; the Venera program by the USSR; and the Vega missions through international cooperation. Furthermore, the US National Research Council (NRC), in the 2003 Solar System Exploration (SSE) Decadal Survey, identified Venus as a high priority target, thus demonstrating a continuing interest in Earth's sister planet. In response to the NRC recommendation, the 2005 NASA SSE Roadmap included a number of potential Venus missions arching through all mission classes from small Discovery, to medium New Frontiers and to large Flagship class missions. While missions in all of these classes could be designed as orbiters with remote sensing capabilities, the desire for scientific advancements beyond our current knowledge - including what we expect to learn from the ongoing ESA Venus Express mission - point to in-situ exploration of Venus.

  17. A roadmap for the integration of culture into developmental psychopathology.

    Science.gov (United States)

    Causadias, José M

    2013-11-01

    In this paper, I propose a roadmap for the integration of culture in developmental psychopathology. This integration is pressing because culture continues to be somewhat disconnected from theory, research, training, and interventions in developmental psychopathology, thus limiting our understanding of the epigenesis of mental health. I argue that in order to successfully integrate culture into developmental psychopathology, it is crucial to (a) study cultural development, (b) consider both individual-level and social-level cultural processes, (c) examine the interplay between culture and biology, and (d) promote improved and direct cultural assessment. I provide evidence in support of each of these guidelines, present alternative conceptual frameworks, and suggest new lines of research. Hopefully, that these directions will contribute to the emerging field of cultural development and psychopathology, which focuses on the elucidation of the cultural processes that initiate, maintain, or derail trajectories of normal and abnormal behavior.

  18. A Research Roadmap for Complementary and Alternative Medicine

    DEFF Research Database (Denmark)

    Fischer, F.; Lewith, G.; Witt, C. M.

    2014-01-01

    Background: The CAMbrella coordination action was funded within the Framework Programme 7. Its aim is to provide a research roadmap for clinical and epidemiological research for complementary and alternative medicine (CAM) that is appropriate for the health needs of European citizens and acceptable...... evaluation of the overall effectiveness of CAM as an additional or alternative treatment strategy in real-world settings. Research into effects of context and meaning: The impact of effects of context and meaning on the outcome of CAM treatments must be investigated; it is likely that they are significant....... Research into different models of CAM health care integration: There are different models of CAM being integrated into conventional medicine throughout Europe, each with their respective strengths and limitations. These models should be described and concurrently evaluated; innovative models of CAM...

  19. Situation awareness of active distribution network: roadmap, technologies, and bottlenecks

    DEFF Research Database (Denmark)

    Lin, Jin; Wan, Can; Song, Yonghua

    2016-01-01

    With the rapid development of local generation and demand response, the active distribution network (ADN), which aggregates and manages miscellaneous distributed resources, has moved from theory to practice. Secure and optimal operations now require an advanced situation awareness (SA) system so...... in the project of developing an SA system as the basic component of a practical active distribution management system (ADMS) deployed in Beijing, China, is presented. This paper reviews the ADN’s development roadmap by illustrating the changes that are made in elements, topology, structure, and control scheme....... Taking into consideration these hardware changes, a systematic framework is proposed for the main components and the functional hierarchy of an SA system for the ADN. The SA system’s implementation bottlenecks are also presented, including, but not limited to issues in big data platform, distribution...

  20. Structured Crowdsourcing: A B2B Innovation Roadmap

    DEFF Research Database (Denmark)

    Edgeman, Rick; Engell, Toke; Jensen, Nik Grewy

    Crowdsourcing is an increasingly popular source of both ideas and funding. Crowdsourcing in a B2B context is less well understood and, as such, much of our discussion will highlight business-to-business crowdsourcing. More generally discussion will address crowdsourcing relative to innovation...... from crowd-sourcing efforts. The roadmap emphasizes on early stages in the overall innovation management activity that is related to development and specification of the task to be crowdsourced, the identification of the crowd, the creation of the environment to connect the crowdsourcer, the task...... and the crowd, motivation of the crowd, and actual activities in reaching the crowd. Managing the input from the crowd is regarded as a later stage in the overall innovation management but also as a focal point in the arguments for improving B2B crowdsourcing. In crowd selection processes this paper aims...

  1. Roadmap towards justice in urban climate adaptation research

    Science.gov (United States)

    Shi, Linda; Chu, Eric; Anguelovski, Isabelle; Aylett, Alexander; Debats, Jessica; Goh, Kian; Schenk, Todd; Seto, Karen C.; Dodman, David; Roberts, Debra; Roberts, J. Timmons; Vandeveer, Stacy D.

    2016-02-01

    The 2015 United Nations Climate Change Conference in Paris (COP21) highlighted the importance of cities to climate action, as well as the unjust burdens borne by the world's most disadvantaged peoples in addressing climate impacts. Few studies have documented the barriers to redressing the drivers of social vulnerability as part of urban local climate change adaptation efforts, or evaluated how emerging adaptation plans impact marginalized groups. Here, we present a roadmap to reorient research on the social dimensions of urban climate adaptation around four issues of equity and justice: (1) broadening participation in adaptation planning; (2) expanding adaptation to rapidly growing cities and those with low financial or institutional capacity; (3) adopting a multilevel and multi-scalar approach to adaptation planning; and (4) integrating justice into infrastructure and urban design processes. Responding to these empirical and theoretical research needs is the first step towards identifying pathways to more transformative adaptation policies.

  2. An ESA roadmap for geobiology in space exploration

    Science.gov (United States)

    Cousins, Claire R.; Cockell, Charles S.

    2016-01-01

    Geobiology, and in particular mineral-microbe interactions, has a significant role to play in current and future space exploration. This includes the search for biosignatures in extraterrestrial environments, and the human exploration of space. Microorganisms can be exploited to advance such exploration, such as through biomining, maintenance of life-support systems, and testing of life-detection instrumentation. In view of these potential applications, a European Space Agency (ESA) Topical Team "Geobiology in Space Exploration" was developed to explore these applications, and identify research avenues to be investigated to support this endeavour. Through community workshops, a roadmap was produced, with which to define future research directions via a set of 15 recommendations spanning three key areas: Science, Technology, and Community. These roadmap recommendations identify the need for research into: (1) new terrestrial space-analogue environments; (2) community level microbial-mineral interactions; (3) response of biofilms to the space environment; (4) enzymatic and biochemical mineral interaction; (5) technical refinement of instrumentation for space-based microbiology experiments, including precursor flight tests; (6) integration of existing ground-based planetary simulation facilities; (7) integration of fieldsite biogeography with laboratory- and field-based research; (8) modification of existing planetary instruments for new geobiological investigations; (9) development of in situ sample preparation techniques; (10) miniaturisation of existing analytical methods, such as DNA sequencing technology; (11) new sensor technology to analyse chemical interaction in small volume samples; (12) development of reusable Lunar and Near Earth Object experimental platforms; (13) utility of Earth-based research to enable the realistic pursuit of extraterrestrial biosignatures; (14) terrestrial benefits and technological spin-off from existing and future space

  3. Technology Road-map - Nuclear Energy. 2015 edition

    International Nuclear Information System (INIS)

    Houssin, Didier; Dujardin, Thierry; Cameron, Ron; Tam, Cecilia; Paillere, Henri; Baroni, Marco; Bromhead, Amos; Baritaud, Manual; Cometto, Marco; Gaghen, Rebecca; Herzog, Antoine; Remme, Uwe; Urso, Maria-Elena; Vance, Robert

    2015-01-01

    Since the release in 2010 of Technology Road-map: Nuclear Energy (IEA/NEA, 2010), a number of events have had a significant impact on the global energy sector and on the outlook for nuclear energy. They include the Fukushima Daiichi nuclear power plant (NPP) accident in March 2011, the global financial and economic crises that hit many industrialised countries during the period 2008-10 and failings in both electricity and CO 2 markets. Despite these additional challenges, nuclear energy still remains a proven low-carbon source of base-load electricity, and many countries have reaffirmed the importance of nuclear energy within their countries' energy strategies. To achieve the goal of limiting global temperature increases to just 2 deg. C by the end of the century, a halving of global energy-related emissions by 2050 will be needed. A wide range of low-carbon energy technologies will be needed to support this transition, including nuclear energy. This edition of the nuclear road-map prepared jointly by the IEA and NEA take into account recent challenges facing the development of this technology. The 2015 edition of the Nuclear Energy Technology Road-map aims to: Outline the current status of nuclear technology development and the need for additional R and D to address increased safety requirements and improved economics. Provide an updated vision of the role that nuclear energy could play in a low-carbon energy system, taking into account changes in nuclear policy in various countries, as well as the current economics of nuclear and other low-carbon electricity technologies. Identify barriers and actions needed to accelerate the development of nuclear technologies to meet the Road-map vision. Share lessons learnt and good practices in nuclear safety and regulation, front- and back-end fuel cycle practices, construction, decommissioning, financing, training, capacity building and communication. Key findings: Nuclear power is the largest source of low

  4. The European Hematology Association Roadmap for European Hematology Research : A consensus document

    NARCIS (Netherlands)

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology

  5. Implementation Plan for Chemical Industry R&D Roadmap for Nanomaterials by Design

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-04-01

    The purpose of this effort is to develop an implementation plan to realize the vision and goals identified in the Chemical Industry R&D Roadmap for Nanomaterials By Design: From Fundamentals to Function.

  6. Comparative study on cytotoxicity effect of biological and commercial synthesized nanosilver on human gastric carcinoma and normal lung fibroblast cell lines

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Rashmezad

    2015-03-01

    Full Text Available Background: Biosynthesis of nanoparticles has attracted the attention of the scientific community in nanotechnology and biotechnology due to their extensive application in the area of material sciences and medicine. Nowadays, despite a various application of nanomaterial’s, there is a little information about their impact on human health. In this study, we investigated the comparative study on cytotoxicity effect of biological and commercial synthesized nanosilver on human gastric carcinoma (AGS and normal lung fibroblast (MRC-5 cell lines. Methods: The current experimental study was carried out in Islamic Azad University, East Tehran Branch, from April to November 2014. The biological synthesis of nanosilver was obtained from Eucalyptus plant extract as a reducing agent. Further to more analysis, morphological study on size and shape of developed biological nanosilver was characterized by performing scanning electron microscopy and dynamic light scattering. AGS and MCR-5 cell lines were treated with various concentration of nanosilver for 24, 48 and 72 hours. Finally, the cell viability was evaluated by using MTT assay. Results: The results show that the nanosilver exerts a dose-dependent inhibitory effect on viability of cells. At 100µg/mL of commercial and biological synthesized nanosilver, the viability of AGS was reduced to 7.47±0.002% (P=0.002 and 3.65±0.01% (P=0.003 after 72 hours, respectively. In addition, the viability of MRC-5 at the same condition was reduced to 10.27±0.19% (P=0.001 and 9.16±1.53% (P=0.002, respectively. Conclusion: Based on a thorough literature surveys, the present study is the first research about biosynthesis of nanosilver using Eucalyptus plant extract. This eco-friendly and cost effective method can be used for large scale production of silver nanoparticle. In addition, based on the current obtained data, commercial and biological synthesized nanosilver can more inhibitory effect on cancer cells compared

  7. Determination of the behavior and performance of commercial Li-Ion pouch cells by means of isothermal calorimeter

    DEFF Research Database (Denmark)

    Khan, Mohammad Rezwan; Swierczynski, Maciej Jozef; Kær, Søren Knudsen

    2016-01-01

    . Temperatures on the surface of the cell are measured using contact thermocouples. Additionally, the heat flux is simultaneously measured with the isothermal calorimeter. This heat flux measurement is used for determining the heat generation inside the cell. Consequently, the important performance constituent...

  8. Influence of aging on the heat and gas emissions from commercial lithium ion cells in case of thermal failure

    Directory of Open Access Journals (Sweden)

    Michael Lammer

    2018-03-01

    Full Text Available A method for thermal ramp experiments on cylindrical 18650 Li-ion cells has been established. The method was applied on pristine cells as well as on devices aged by cyclisation or by storage at elevated temperature respectively. The tested cells comprise three types of LiNi0.8Co0.15Al0.05O2 cells for either high power or high energy applications. The heat flux to and from the cell was investigated. Degradation and exothermic breakdown released large amounts of heat and gas. The total gas and heat emission from cycled cells was significantly larger than emission from cells aged by storage. After aging, the low energy cell ICR18650HE4 did not transgress into thermal runaway. Gas composition changed mainly in the early stage of the experiment. The composition of the initial gas release changed from predominantly CO2 towards hydrocarbons. The thermal runaway emitted for all tests a comparable mixture of H2, CO and CO2.

  9. The Soils and Groundwater – EM-20 S&T Roadmap Quality Assurance Project Plan

    Energy Technology Data Exchange (ETDEWEB)

    Fix, N. J.

    2008-02-11

    The Soils and Groundwater – EM-20 Science and Technology Roadmap Project is a U.S. Department of Energy, Office of Environmental Management-funded initiative designed to develop new methods, strategies and technology for characterizing, modeling, remediating, and monitoring soils and groundwater contaminated with metals, radionuclides, and chlorinated organics. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by EM-20 Roadmap Project staff.

  10. Towards a nuclear energy technology roadmap. A new service to the nuclear community

    International Nuclear Information System (INIS)

    Van Den Durpel, Luc; Thomas, Chris Creighton

    2005-01-01

    The role of nuclear energy in a future sustainable energy mix has been the subject of debates over the past few years. The future for nuclear energy will not only depend on this energy market development and the socio-political environment, but also on the innovation potential of the nuclear community to cope with the ever shorter business cycles in the energy market and the inherently longer term horizon needed in developing nuclear energy at its potential. Today's nuclear R and D community is in a transition phase, i.e. from former 'national' R and D-organisational structure to a truly international research area based on partnerships between organisations and companies creating networks-of-excellence. Several studies in the recent past have indicated the need for a shared vision in guiding this process. Identification of shared R and D-programmes, mergers and acquisitions of organizations and companies, knowledge gap analysis and the strategic mapping for each organization or company active in this nuclear R and D community. Technology Roadmapping is the appropriate tool to respond to these needs. Several stand-alone nuclear roadmap activities have been undertaken but lacked the possibility to analyse and make use of the synergies and interactions inherent to this technology development. The development has started of a master nuclear roadmap portal covering all the roadmap and technology foresight information in one so-called master nuclear roadmap. This master nuclear roadmap is implemented in an electronic online format allowing easy access, easy updating and lots of functionalities which may not be offered by traditional snap-shot roadmap reports. The paper will bring an overview on the role that technology roadmapping is playing in various industry sectors and the added value it may bring in the nuclear technology sector on a organizational as well as technology sector level. The paper will highlight the current status of this new initiative. (author)

  11. Lean Manufacturing Implementation for Multinational Companies with Production Subsidiary in Brazil: Development of A Roadmap

    Directory of Open Access Journals (Sweden)

    L. Goehnera,

    2016-06-01

    Full Text Available Foreign multinational companies with a production subsidiary in Brazil are in general recognized as high-level productive companies; however, their productivity potential is mostly not fully achieved. Lean Manufacturing (LM has been proved as a valuable aid to achieve competitiveness in the long run. Regarding the rising importance of successfully implementing LM at multinationals in Brazil and an apparent lack of discussion regarding LM in Brazil this paper aims to propose a comprehensive implementation roadmap, which enables a multinational on a basis of a systematic approach, to achieve an advanced sustainable LM system in a practical manner. The insights of literature and case studies are combined to develop the roadmap. The roadmap was developed so that both companies, those, which have not started yet their journey towards LM, as well as those that have taken already the first steps can use the roadmap. However, the roadmap was built on a broad empirical basis. It should be noticed that it is impossible to consider all factors influencing the LMI at multinationals operating in Brazil in a real world setting. As a result, the roadmap should not be regarded as a ready implementation plan, which has to be strictly followed. Instead, it should be seen as a guideline, which helps a multinational to develop its own, detailed and fitted plan for successfully implementing LM and establishing a learning organization.

  12. Effect of commercial enzymes on berry cell wall deconstruction in the context of intravineyard ripeness variation under winemaking conditions

    DEFF Research Database (Denmark)

    Gao, Yu; Fangel, Jonatan Ulrik; Willats, William George Tycho

    2016-01-01

    Significant intravineyard variation in grape berry ripening occurs within vines and between vines. However, no cell wall data are available on such variation. Here we used a checkerboard panel design to investigate ripening variation in pooled grape bunches for enzyme-assisted winemaking...... positively influence the consistency of winemaking and provides a foundation for further research into the relationship between grape berry cell wall architecture and enzyme formulations....

  13. Evaluation of the efficacy of commercial sanitizers against adhered and planktonic cells of Listeria monocytogenes and Salmonella spp.

    Directory of Open Access Journals (Sweden)

    Julia Carballo

    2012-09-01

    Full Text Available Antimicrobial activities of two commercial disinfectants, alone or combined with heat, against three Salmonella strains and three Listeria monocytogenes strains were studied. The efficacy of disinfectants against planktonic bacteria and bacteria attached to three food contact industrial surfaces (stainless steel, polytetraflourethylene, and rubber was investigated. The tests were conducted using the sanitizer (quaternary ammonium compounds, and alquyldiethylenediamineglycine and di-alquyldiamineethylglycine concentrations recommended by the manufacturers, and concentrations twice and four times higher than those values. The recommended concentrations were not effective to kill bacteria, especially when they were attached to surfaces. Concentrations of disinfectants twice and four times higher than those recommended were needed to fully eliminate planktonic bacteria. These same sanitizer concentrations were not sufficient to remove attached bacteria. To remove them from the surfaces, a treatment with recommended concentrations in combination with heat was needed. Our results indicate that these two pathogenic bacteria could survive common sanitation programs used in the food industry.

  14. Commercial LANDSAT?

    Science.gov (United States)

    Private industry should assume responsibility either for the United States' land satellite (LANDSAT) system or for both the land and the weather satellite systems, recommends the Land Remote Sensing Satellite Advisory Committee. The committee (Eos, June 29, 1982, p. 553), composed of representatives from academia, industry, and government, has a working group that is evaluating the potential for commercialization of remote sensing satellites.The recommendations call for industry ownership or operation of either or both of the remote sensing systems, but only up to and including the holding of raw, unprocessed data. The National Aeronautics and Space Administration (NASA) currently operates LANDSAT but will be relinquishing its responsibility to the National Oceanic and Atmospheric Administration (NOAA) on January 31. NOAA already operates the U.S. civilian weather satellite service, which includes the NOAA-5, NOAA-6, and the Geostationary Operational Environmental (GOES) satellites (Eos, June 2, 1981, p. 522).

  15. ANCRE alliance: Road-map for nuclear materials

    International Nuclear Information System (INIS)

    Touboul, F.; Carre, F.

    2013-01-01

    Created in 2009 by the Higher Education and Research ministry and by the Ecology ministry, ANCRE, the National Alliance for Energy Research Coordination aims at enhancing the efficiency of French research in the field of energy by promoting partnerships and synergies between public and private sectors (research organizations, universities and companies). ANCRE aims to propose a coordinated strategy for research and innovation projects. Beyond its four founding members, CEA, CNRS, IFPEN and CPU, ANCRE brings together all the French public research organizations concerned with energy issues, and has strong links with the industrial sector. Among the 10 programmatic groups of ANCRE, one is specifically dedicated to Nuclear Energies (fission and fusion). This group has proposed road-maps in five scientific fields, considered as strategic for R and D, in relation to industrial objectives and scientific bottlenecks: nuclear materials, nuclear chemistry, reactor physics, instrumentation and fusion. For twenty to thirty years, R and D on nuclear materials has evolved from the heavy metallurgy of the first generation of power reactors to the nano-materials science under extreme conditions for present and future needs. Nuclear systems are characterized by extreme operating conditions: high temperatures, mechanical stresses, radiations, corrosive environment, and long durations. In order to deal with these extreme conditions, it is necessary to have a sound knowledge of the materials, to the finest scale. R and D development was made possible by advances in materials science, in relation to more efficient observation means (now reaching the atom scale) and deeper control of the microstructure. Development of simulation methods at the atomic level (ab initio, classical molecular dynamics, kinetic Monte Carlo, etc.) have also allowed a better understanding of phenomena at their most fundamental level. Material performance issues, however, remain significant, as the performance

  16. The NASA Planetary Data System Roadmap Study for 2017 - 2026

    Science.gov (United States)

    McNutt, R. L., Jr.; Gaddis, L. R.; Law, E.; Beyer, R. A.; Crombie, M. K.; Ebel, D. S. S.; Ghosh, A.; Grayzeck, E.; Morgan, T. H.; Paganelli, F.; Raugh, A.; Stein, T.; Tiscareno, M. S.; Weber, R. C.; Banks, M.; Powell, K.

    2017-12-01

    NASA's Planetary Data System (PDS) is the formal archive of >1.2 petabytes of data from planetary exploration, science, and research. Initiated in 1989 to address an overall lack of attention to mission data documentation, access, and archiving, the PDS has evolved into an online collection of digital data managed and served by a federation of six science discipline nodes and two technical support nodes. Several ad hoc mission-oriented data nodes also provide complex data interfaces and access for the duration of their missions. The recent Planetary Data System Roadmap Study for 2017 to 2026 involved 15 planetary science community members who collectively prepared a report summarizing the results of an intensive examination of the current state of the PDS and its organization, management, practices, and data holdings (https://pds.jpl.nasa.gov/roadmap/PlanetaryDataSystemRMS17-26_20jun17.pdf). The report summarizes the history of the PDS, its functions and characteristics, and how it has evolved to its present form; also included are extensive references and documentary appendices. The report recognizes that as a complex, evolving, archive system, the PDS must constantly respond to new pressures and opportunities. The report provides details on the challenges now facing the PDS, 19 detailed findings, suggested remediations, and a summary of what the future may hold for planetary data archiving. The findings cover topics such as user needs and expectations, data usability and discoverability (i.e., metadata, data access, documentation, and training), tools and file formats, use of current information technologies, and responses to increases in data volume, variety, complexity, and number of data providers. In addition, the study addresses the possibility of archiving software, laboratory data, and measurements of physical samples. Finally, the report discusses the current structure and governance of the PDS and its impact on how archive growth, technology, and new

  17. IRIS Responsiveness to Generation IV Road-map Goals

    International Nuclear Information System (INIS)

    Carelli, M.D.; Paramonov, D.V.; Petrovic, B.

    2002-01-01

    The DOE Generation IV road-map process is in its second and final year. Almost one hundred concepts submitted from all over the world have been reviewed against the Generation IV goals of resources sustainability; safety and reliability; and, economics. Advanced LWRs are taken as the reference point. IRIS (International Reactor Innovative and Secure), a 100-335 MWe integral light water reactor being developed by a vast international consortium led by Westinghouse, is one on the concepts being considered in the road-map and is perhaps the most visible representative of the concept set known as Integral Primary System Reactors (IPSR). This paper presents how IRIS satisfies the prescribed goals. The first goal of resource sustainability includes criteria like utilization of fuel resources, amount and toxicity of waste produced, environmental impact, proliferation and sabotage resistance. As a thermal reactor IRIS does not have the same fuel utilization as fast reactors. However, it has a significant flexibility in fuel cycles as it is designed to utilize either UO 2 or MOX with straight burn cycles of 4 to 10 years, depending on the fissile content. High discharge burnup and Pu recycling result in good fuel utilization and lower waste; IRIS has also attractive proliferation resistance characteristics, due to the reduced accessibility of the fuel. The safety and reliability goal include reliability, workers' exposure, robust safety features, models with well characterized uncertainty, source term and mechanisms of energy release, robust mitigation of accidents. IRIS is significantly better than advanced LWRs because of its safety by design which eliminates a variety of accidents such as LOCAs, its containment vessel coupled design which maintains the core safely covered during the accident sequences, its design simplification features such as no (or reduced) soluble boron, internal shielding and four-year refueling/maintenance interval which significantly reduce

  18. Strategic Roadmap for the Development of an Interstellar Space Program

    Science.gov (United States)

    Gifra, M.; Peeters, W.

    Recent technological advances and scientific discoveries, particularly in astronomy and space technology, are opening our minds into the deepest realms of the universe, and also they are bringing a new era of space exploration and development. This sense of entering into a new era of space exploration is being boosted by the permanent discovery of new planets - to date, there are 684 confirmed extrasolar planets [1] - outside our solar system. The possibility that astronomers may soon find a habitable extrasolar planet near Earth and the recent advances in space propulsion that could reduce travel times have stimulated the space community to consider the development of an interstellar manned mission. But this scenario of entering into a new era of space development is ultimately contingent on the outcome of the actual world's economic crisis. The current financial crisis, on top of recent national and sovereign debts problems, could have serious consequences for space exploration and development as the national budgets for space activities are to freeze [2].This paper proposes a multi-decade space program for an interstellar manned mission. It designs a roadmap for the achievement of interstellar flight capability within a timeframe of 40 years, and also considers different scenarios where various technological and economical constraints are taken into account in order to know if such a space endeavour could be viable. It combines macro-level scenarios with a strategic roadmap to provide a framework for condensing all information in one map and timeframe, thus linking decision-making with plausible scenarios. The paper also explores the state of the art of space technologies 20 to 40 years in the future and its potential economic impact. It estimates the funding requirements, possible sources of funds, and the potential returns.The Interstellar Space Program proposed in this paper has the potential to help solve the global crisis by bringing a new landscape of

  19. A stable reagent system for screening and identifying red blood cell irregular antibodies: application to commercial antibodies.

    Science.gov (United States)

    Million, L; Pellerin, C; Marchand-Arvier, M; Vigneron, C

    1998-01-01

    Development of a new solid-phase system for screening and identifying irregular red cell antibodies. Red blood cell membranes were prepared by a semi-automated procedure in which the hemolysate solution was passed through a hollow-fiber system. The membranes were fixed to the solid phase (microtiter plates) by centrifugation and incubated with 8% fat-free milk. Antibodies added to the microtiter plate were detected by anti-human antibodies adsorbed onto yellow latex particles. The system had good sensitivity (titer antibodies that are important in transfusion.

  20. Commercial applications

    Science.gov (United States)

    The near term (one to five year) needs of domestic and foreign commercial suppliers of radiochemicals and radiopharmaceuticals for electromagnetically separated stable isotopes are assessed. Only isotopes purchased to make products for sale and profit are considered. Radiopharmaceuticals produced from enriched stable isotopes supplied by the Calutron facility at ORNL are used in about 600,000 medical procedures each year in the United States. A temporary or permanent disruption of the supply of stable isotopes to the domestic radiopharmaceutical industry could curtail, if not eliminate, the use of such diagnostic procedures as the thallium heart scan, the gallium cancer scan, the gallium abscess scan, and the low radiation dose thyroid scan. An alternative source of enriched stable isotopes exist in the USSR. Alternative starting materials could, in theory, eventually be developed for both the thallium and gallium scans. The development of a new technology for these purposes, however, would take at least five years and would be expensive. Hence, any disruption of the supply of enriched isotopes from ORNL and the resulting unavailability of critical nuclear medicine procedures would have a dramatic negative effect on the level of health care in the United States.

  1. Roadmap for Nondestructive Evaluation of Reactor Pressure Vessel Research and Development by the Light Water Reactor Sustainability Program

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Cyrus M [ORNL; Nanstad, Randy K [ORNL; Clayton, Dwight A [ORNL; Matlack, Katie [Georgia Institute of Technology; Ramuhalli, Pradeep [Pacific Northwest National Laboratory (PNNL); Light, Glenn [Southwest Research Institute, San Antonio

    2012-09-01

    The Department of Energy s (DOE) Light Water Reactor Sustainability (LWRS) Program is a five year effort which works to develop the fundamental scientific basis to understand, predict, and measure changes in materials and systems, structure, and components as they age in environments associated with continued long-term operations of existing commercial nuclear power reactors. This year, the Materials Aging and Degradation (MAaD) Pathway of this program has placed emphasis on emerging Non-Destructive Evaluation (NDE) methods which support these objectives. DOE funded Research and Development (R&D) on emerging NDE techniques to support commercial nuclear reactor sustainability is expected to begin next year. This summer, the MAaD Pathway invited subject matter experts to participate in a series of workshops which developed the basis for the research plan of these DOE R&D NDE activities. This document presents the results of one of these workshops which are the DOE LWRS NDE R&D Roadmap for Reactor Pressure Vessels (RPV). These workshops made a substantial effort to coordinate the DOE NDE R&D with that already underway or planned by the Electric Power Research Institute (EPRI) and the Nuclear Regulatory Commission (NRC) through their representation at these workshops.

  2. Roadmap for sustainable water resources in southwestern North America.

    Science.gov (United States)

    Gleick, Peter H

    2010-12-14

    The management of water resources in arid and semiarid areas has long been a challenge, from ancient Mesopotamia to the modern southwestern United States. As our understanding of the hydrological and climatological cycles has improved, and our ability to manipulate the hydrologic cycle has increased, so too have the challenges associated with managing a limited natural resource for a growing population. Modern civilization has made remarkable progress in water management in the past few centuries. Burgeoning cities now survive in desert regions, relying on a mix of simple and complex technologies and management systems to bring adequate water and remove wastewater. These systems have permitted agricultural production and urban concentrations to expand in regions previously thought to have inadequate moisture. However, evidence is also mounting that our current management and use of water is unsustainable. Physical, economic, and ecological limits constrain the development of new supplies and additional water withdrawals, even in regions not previously thought vulnerable to water constraints. New kinds of limits are forcing water managers and policy makers to rethink previous assumptions about population, technology, regional planning, and forms of development. In addition, new threats, especially the challenges posed by climatic changes, are now apparent. Sustainably managing and using water in arid and semiarid regions such as the southwestern United States will require new thinking about water in an interdisciplinary and integrated way. The good news is that a wide range of options suggest a roadmap for sustainable water management and use in the coming decades.

  3. Quo Vadis Venomics? A Roadmap to Neglected Venomous Invertebrates

    Science.gov (United States)

    von Reumont, Bjoern Marcus; Campbell, Lahcen I.; Jenner, Ronald A.

    2014-01-01

    Venomics research is being revolutionized by the increased use of sensitive -omics techniques to identify venom toxins and their transcripts in both well studied and neglected venomous taxa. The study of neglected venomous taxa is necessary both for understanding the full diversity of venom systems that have evolved in the animal kingdom, and to robustly answer fundamental questions about the biology and evolution of venoms without the distorting effect that can result from the current bias introduced by some heavily studied taxa. In this review we draw the outlines of a roadmap into the diversity of poorly studied and understood venomous and putatively venomous invertebrates, which together represent tens of thousands of unique venoms. The main groups we discuss are crustaceans, flies, centipedes, non-spider and non-scorpion arachnids, annelids, molluscs, platyhelminths, nemerteans, and echinoderms. We review what is known about the morphology of the venom systems in these groups, the composition of their venoms, and the bioactivities of the venoms to provide researchers with an entry into a large and scattered literature. We conclude with a short discussion of some important methodological aspects that have come to light with the recent use of new -omics techniques in the study of venoms. PMID:25533518

  4. Quo Vadis Venomics? A Roadmap to Neglected Venomous Invertebrates

    Directory of Open Access Journals (Sweden)

    Bjoern Marcus von Reumont

    2014-12-01

    Full Text Available Venomics research is being revolutionized by the increased use of sensitive -omics techniques to identify venom toxins and their transcripts in both well studied and neglected venomous taxa. The study of neglected venomous taxa is necessary both for understanding the full diversity of venom systems that have evolved in the animal kingdom, and to robustly answer fundamental questions about the biology and evolution of venoms without the distorting effect that can result from the current bias introduced by some heavily studied taxa. In this review we draw the outlines of a roadmap into the diversity of poorly studied and understood venomous and putatively venomous invertebrates, which together represent tens of thousands of unique venoms. The main groups we discuss are crustaceans, flies, centipedes, non-spider and non-scorpion arachnids, annelids, molluscs, platyhelminths, nemerteans, and echinoderms. We review what is known about the morphology of the venom systems in these groups, the composition of their venoms, and the bioactivities of the venoms to provide researchers with an entry into a large and scattered literature. We conclude with a short discussion of some important methodological aspects that have come to light with the recent use of new -omics techniques in the study of venoms.

  5. Roadmap for sustainable water resources in southwestern North America

    Science.gov (United States)

    Gleick, Peter H.

    2010-01-01

    The management of water resources in arid and semiarid areas has long been a challenge, from ancient Mesopotamia to the modern southwestern United States. As our understanding of the hydrological and climatological cycles has improved, and our ability to manipulate the hydrologic cycle has increased, so too have the challenges associated with managing a limited natural resource for a growing population. Modern civilization has made remarkable progress in water management in the past few centuries. Burgeoning cities now survive in desert regions, relying on a mix of simple and complex technologies and management systems to bring adequate water and remove wastewater. These systems have permitted agricultural production and urban concentrations to expand in regions previously thought to have inadequate moisture. However, evidence is also mounting that our current management and use of water is unsustainable. Physical, economic, and ecological limits constrain the development of new supplies and additional water withdrawals, even in regions not previously thought vulnerable to water constraints. New kinds of limits are forcing water managers and policy makers to rethink previous assumptions about population, technology, regional planning, and forms of development. In addition, new threats, especially the challenges posed by climatic changes, are now apparent. Sustainably managing and using water in arid and semiarid regions such as the southwestern United States will require new thinking about water in an interdisciplinary and integrated way. The good news is that a wide range of options suggest a roadmap for sustainable water management and use in the coming decades. PMID:21149725

  6. Supersonics/Airport Noise Plan: An Evolutionary Roadmap

    Science.gov (United States)

    Bridges, James

    2011-01-01

    This presentation discusses the Plan for the Airport Noise Tech Challenge Area of the Supersonics Project. It is given in the context of strategic planning exercises being done in other Projects to show the strategic aspects of the Airport Noise plan rather than detailed task lists. The essence of this strategic view is the decomposition of the research plan by Concept and by Tools. Tools (computational, experimental) is the description of the plan that resources (such as researchers) most readily identify with, while Concepts (here noise reduction technologies or aircraft configurations) is the aspects that project management and outside reviewers most appreciate as deliverables and milestones. By carefully cross-linking these so that Concepts are addressed sequentially (roughly one after another) by researchers developing/applying their Tools simultaneously (in parallel with one another), the researchers can deliver milestones at a reasonable pace while doing the longer-term development that most Tools in the aeroacoustics science require. An example of this simultaneous application of tools was given for the Concept of High Aspect Ratio Nozzles. The presentation concluded with a few ideas on how this strategic view could be applied to the Subsonic Fixed Wing Project's Quiet Aircraft Tech Challenge Area as it works through its current roadmapping exercise.

  7. Modeling Influenza Virus Infection: A Roadmap for Influenza Research

    Directory of Open Access Journals (Sweden)

    Alessandro Boianelli

    2015-10-01

    Full Text Available Influenza A virus (IAV infection represents a global threat causing seasonal outbreaks and pandemics. Additionally, secondary bacterial infections, caused mainly by Streptococcus pneumoniae, are one of the main complications and responsible for the enhanced morbidity and mortality associated with IAV infections. In spite of the significant advances in our knowledge of IAV infections, holistic comprehension of the interplay between IAV and the host immune response (IR remains largely fragmented. During the last decade, mathematical modeling has been instrumental to explain and quantify IAV dynamics. In this paper, we review not only the state of the art of mathematical models of IAV infection but also the methodologies exploited for parameter estimation. We focus on the adaptive IR control of IAV infection and the possible mechanisms that could promote a secondary bacterial coinfection. To exemplify IAV dynamics and identifiability issues, a mathematical model to explain the interactions between adaptive IR and IAV infection is considered. Furthermore, in this paper we propose a roadmap for future influenza research. The development of a mathematical modeling framework with a secondary bacterial coinfection, immunosenescence, host genetic factors and responsiveness to vaccination will be pivotal to advance IAV infection understanding and treatment optimization.

  8. SETI 2020: a roadmap for future SETI observing projects

    Science.gov (United States)

    Tarter, Jill C.

    2001-08-01

    A recent series of workshops has laid out a roadmap for SETI research at the SETI Institute for the next few decades. Three different approaches were identified. 1) Continue the radio search: build an affordable array incorporating consumer market technologies, expand the search frequency, and increase the target list to 100,000 stars. This array will also serve as a technology demonstration and enable the international radio astronomy community to realize an array that is a hundred times larger and capable (among other things) of searching a million stars. 2) Begin searches for very fast optical pulses from a million stars. 3) As Moore's Law delivers increased computational capacity, build an omni-directional sky survey array capable of detecting strong, transient, radio signals from billions of stars. SETI could succeed tomorrow, or it may be an endeavor for multiple generations. We are a very young technology in a very old galaxy. While our own leakage radiation continues to outshine the Sun at many frequencies, we remain detectable to others. When our use of the spectrum becomes more efficient, it will be time to consider deliberate transmissions and the really tough questions: Who will speak for Earth? What will they say?

  9. Critical review of the molecular design progress in non-fullerene electron acceptors towards commercially viable organic solar cells

    KAUST Repository

    Wadsworth, Andrew

    2018-04-26

    Fullerenes have formed an integral part of high performance organic solar cells over the last 20 years, however their inherent limitations in terms of synthetic flexibility, cost and stability have acted as a motivation to develop replacements; the so-called non-fullerene electron acceptors. A rapid evolution of such materials has taken place over the last few years, yielding a number of promising candidates that can exceed the device performance of fullerenes and provide opportunities to improve upon the stability and processability of organic solar cells. In this review we explore the structure-property relationships of a library of non-fullerene acceptors, highlighting the important chemical modifications that have led to progress in the field and provide an outlook for future innovations in electron acceptors for use in organic photovoltaics.

  10. Plasma α-tocopherol content and its relationship with milk somatic cells count in Italian commercial herds.

    Directory of Open Access Journals (Sweden)

    Adriano Pilotto

    2015-07-01

    We did not observe a correlation between plasmatic vitamin E and somatic cell score, and this can be explained by the low level of somatic cell score (averages 1.64 and 1.26. The lowest value of vitamin E was observed at parturition (1.64 µg/ml and 1.95 µg/ml. A significant (P<0.01 negative (-20% correlation was observed between NEFA serum content and α-tocopherol plasma concentration. Serum selenium content was positively correlated (+42%, P<0.0001 to zinc concentration. Grouping cows on the basis of their plasma α-tocopherol content higher or lower than 3 μg/mL at dry off, SCS at 30 and 60 DIM tended to be higher in lactating animals with lower content of α-tocopherol (1.12 vs. 1.72, P=0.18 at 30d; 0.92 vs. 1.72, P=0.07 at 60d. However, plasma α-tocopherol content at dry off could be usefully correlated with somatic cell count in fresh cows.

  11. Hydrogen and fuel cells

    International Nuclear Information System (INIS)

    2006-06-01

    This road-map proposes by the Group Total aims to inform the public on the hydrogen and fuel cells. It presents the hydrogen technology from the production to the distribution and storage, the issues as motor fuel and fuel cells, the challenge for vehicles applications and the Total commitments in the domain. (A.L.B.)

  12. Research and Development Roadmap for Water Heating Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Goetzler, William [Navigant Consulting Inc.; Gagne, Claire [Navigant Consulting Inc.; Baxter, Van D [ORNL; Lutz, James [Lawrence Berkeley National Laboratory (LBNL); Merrigan, Tim [National Renewable Energy Laboratory (NREL); Katipamula, Srinivas [Pacific Northwest National Laboratory (PNNL)

    2011-10-01

    Although water heating is an important energy end-use in residential and commercial buildings, efficiency improvements in recent years have been relatively modest. However, significant advancements related to higher efficiency equipment, as well as improved distribution systems, are now viable. DOE support for water heating research, development and demonstration (RD&D) could provide the impetus for commercialization of these advancements.

  13. Real-time monitoring of 3T3-L1 preadipocyte differentiation using a commercially available electric cell-substrate impedance sensor system.

    Science.gov (United States)

    Kramer, Adam H; Joos-Vandewalle, Julia; Edkins, Adrienne L; Frost, Carminita L; Prinsloo, Earl

    2014-01-24

    Real-time analysis offers multiple benefits over traditional end point assays. Here, we present a method of monitoring the optimisation of the growth and differentiation of murine 3T3-L1 preadipocytes to adipocytes using the commercially available ACEA xCELLigence Real-Time Cell Analyser Single Plate (RTCA SP) system. Our findings indicate that the ACEA xCELLigence RTCA SP can reproducibly monitor the primary morphological changes in pre- and post-confluent 3T3-L1 fibroblasts induced to differentiate using insulin, dexamethasone, 3-isobutyl-1-methylxanthine and rosiglitazone; and may be a viable primary method of screening compounds for adipogenic factors. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Effects of the nanotopographic surface structure of commercially pure titanium following anodization-hydrothermal treatment on gene expression and adhesion in gingival epithelial cells.

    Science.gov (United States)

    Takebe, J; Miyata, K; Miura, S; Ito, S

    2014-09-01

    The long-term stability and maintenance of endosseous implants with anodized-hydrothermally treated commercially pure titanium surfaces and a nanotopographic structure (SA-treated c.p.Ti) depend on the barrier function provided by the interface between the transmucosal portion of the implant surface and the peri-implant epithelium. This study investigated the effects of extracellular and intracellular gene expression in adherent gingival epithelial cells cultured for 1-7 days on SA-treated c.p.Ti implant surfaces compared to anodic oxide (AO) c.p.Ti and c.p.Ti disks. Scanning electron microscopy (SEM) showed filopodium-like extensions bound closely to the nanotopographic structure of SA-treated c.p.Ti at day 7 of culture. Gene expressions of focal adhesion kinase, integrin-α6β4, and laminin-5 (α3, β3, γ2) were significantly higher on SA-treated c.p.Ti than on c.p.Ti or AO c.p.Ti after 7 days (Pcells adhere to SA-treated c.p.Ti as the transmucosal portion of an implant, and that this interaction markedly improves expression of focal adhesion molecules and enhances the epithelial cell phenotype. The cellular gene expression responses driving extracellular and intracellular molecular interactions thus play an important role in maintenance at the interface between SA-treated c.p.Ti implant surfaces and the gingival epithelial cells. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. SUPPLIER SELECTION STRATEGY AND MANUFACTURING FLEXIBILITY: IMPACT OF QUALITY AND TECHNOLOGY ROADMAPS

    Directory of Open Access Journals (Sweden)

    Muhamad Jantan

    2006-01-01

    Full Text Available The study evaluates the relationship between technology, quality, cost and delivery performance-based, supplier selection strategies, and manufacturing flexibilities namely, product flexibility, launch flexibility, and volume flexibility. Moreover, the moderating impact of supplier management strategies, namely quality roadmap and technology roadmap on the above relationships were also explored. The data for the study was drawn from a sample of companies listed in the factory directory published by the Penang Development Corporation (PDC. A postal survey of 120 manufacturers provided a return of 92 usable responses. The results reveal that the selection of suppliers based on technological and quality performance positively affects all the three dimensions of manufacturing flexibility, with complementary effects of good technology and quality roadmaps. Technology and quality roadmaps act as predictors for product and volume flexibilities. However, when launch flexibility is the focus, both technology and quality roadmaps moderate the impact of supplier selection strategies. Details of the findings, theoretical and practical implications, and the research limitation are discussed.

  16. Energy Technology Roadmaps: A Guide to Development and Implementation. 2014 edition

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-03-01

    New low-carbon technologies show clear potential for transforming the global energy system, but a key challenge remains: what steps do governments and industry need to take to ensure their development and deployment? Roadmapping, used for decades in technology-intensive industries, is a useful tool to help address complicated issues strategically at the national, regional and global levels. To help turn political statements and analytical work into concrete action, the International Energy Agency (IEA) is developing a series of global roadmaps devoted to low-carbon energy technologies. Drawing upon the extensive IEA experience, this guide is aimed at providing countries and companies with the context, information and tools needed to design, manage and implement an effective energy technology roadmap process relevant to their own local circumstances and objectives. This edition of the Energy Technology Roadmaps: a guide to development and implementation includes more detailed guidance on how to identify key stakeholders, develop a technology baseline and development of indicators to help track progress against roadmap milestones. The IEA hopes that this guide and the examples and references it offers, together with the new IEA How2Guides, which provide technology-specific guidance, will help national and local policy makers and industry to develop strategies that accelerate the deployment of low-carbon energy technologies worldwide.

  17. Transition Management: Case Study of an Energy Efficiency Technology Roadmap in Turkey

    Directory of Open Access Journals (Sweden)

    Şiir Kilkiş

    2014-12-01

    Full Text Available This paper integrates several streams of literature in transition management and proposes a holistic framework for its application in policy-making. Separate fields of study, such as motors of change and strategic intelligence tools, are unified in a single analytical process. The process involves five steps that may be repeated until a desired policy objective is achieved. The pilot, integrated technology roadmap process that has been launched in Turkey is analyzed as a case study. The Energy Efficiency Technology Roadmap has been completed with the participation of over 160 experts in 5 different stages. It involved the collection of over 349 Delfi statements, their consolidation for a Delfi survey with 16 statements, the analysis of the results, a focal group meeting to develop roadmaps for the 7 selected goals, and the consultation of the roadmaps to the sector. The paper concludes that an integrated technology roadmap process, as described in the pilot case study, provides an advanced version of transition management, which is needed to mobilize research, development, and innovation for sustainable development.

  18. Effects of the nanotopographic surface structure of commercially pure titanium following anodization–hydrothermal treatment on gene expression and adhesion in gingival epithelial cells

    International Nuclear Information System (INIS)

    Takebe, J.; Miyata, K.; Miura, S.; Ito, S.

    2014-01-01

    The long-term stability and maintenance of endosseous implants with anodized–hydrothermally treated commercially pure titanium surfaces and a nanotopographic structure (SA-treated c.p.Ti) depend on the barrier function provided by the interface between the transmucosal portion of the implant surface and the peri-implant epithelium. This study investigated the effects of extracellular and intracellular gene expression in adherent gingival epithelial cells cultured for 1–7 days on SA-treated c.p.Ti implant surfaces compared to anodic oxide (AO) c.p.Ti and c.p.Ti disks. Scanning electron microscopy (SEM) showed filopodium-like extensions bound closely to the nanotopographic structure of SA-treated c.p.Ti at day 7 of culture. Gene expressions of focal adhesion kinase, integrin-α6β4, and laminin-5 (α3, β3, γ2) were significantly higher on SA-treated c.p.Ti than on c.p.Ti or AO c.p.Ti after 7 days (P < 0.05). Our results confirmed that gingival epithelial cells adhere to SA-treated c.p.Ti as the transmucosal portion of an implant, and that this interaction markedly improves expression of focal adhesion molecules and enhances the epithelial cell phenotype. The cellular gene expression responses driving extracellular and intracellular molecular interactions thus play an important role in maintenance at the interface between SA-treated c.p.Ti implant surfaces and the gingival epithelial cells. - Highlights: • SA-treated Ti provides a nanotopographic structure for clinical oral implants. • This could regulate integrin-mediated epithelial cell adhesion and gene expression. • FAK mRNA was significantly higher on SA-treated Ti. • Integrin-α6β4 and laminin-5 mRNA were significantly higher on SA-treated Ti. • Extracellular/intracellular molecular interactions play a key role on SA-treated Ti

  19. Effectively Improved SiO2-TiO2 Composite Films Applied in Commercial Multicrystalline Silicon Solar Cells

    Directory of Open Access Journals (Sweden)

    Chih-Hsiang Yang

    2013-01-01

    Full Text Available Composite silicon dioxide-titanium dioxide (SiO2-TiO2 films are deposited on a large area of 15.6 × 15.6 cm2 textured multicrystalline silicon solar cells to increase the incident light trapped within the device. For further improvement of the antireflective coatings (ARCs quality, dimethylformamide (DMF solution is added to the original SiO2-TiO2 solutions. DMF solution solves the cracking problem, thus effectively decreasing reflectance as well as surface recombination. The ARCs prepared by sol-gel process and plasma-enhanced chemical vapor deposition (PECVD on multicrystalline silicon substrate are compared. The average efficiency of the devices with improved sol-gel ARCs is 16.3%, only 0.5% lower than that of devices with PECVD ARCs (16.8%. However, from equipment depreciation point of view (the expiration date of equipment is generally considered as 5 years, the running cost (USD/watt of sol-gel technique is 80% lower than that of PECVD method for the first five years and 66% lower than that of PECVD method from the start of the sixth year. This result proves that sol-gel-deposited ARCs process has potential applications in manufacturing low-cost, large-area solar cells.

  20. Optimization of Rear Local Al-Contacts on High Efficiency Commercial PERC Solar Cells with Dot and Line Openings

    Directory of Open Access Journals (Sweden)

    Peisheng Liu

    2014-01-01

    Full Text Available Crystalline silicon PERCs with dot or line openings on rear surface were studied here. By measuring the minor carrier lifetimes of the PERCs with dot and line openings, passivation effects of rear surface with dot and line openings were discussed. The performance affected by dot and line openings was analyzed in detail by testing the open-circuit voltages, short-circuit current densities, fill factors, and conversion efficiencies of the PERCs. The results show that the wider space resulted in better minor carrier lifetimes on the rear surface. And the cells with a line opening space of 0.5 mm had an average of 0.22% improvement of conversion efficiency, compared with the cells with full-area Al-BSF. On the other hand, the dot opening PERCs exhibited only a conversion efficiency of 17.4%, although there had been good rear surface reflectivity. The bad Al-Si alloy layer and large hollow densities in dot Al-contacts resulted in bad performance of the PERCs with dot openings.

  1. Anti-proliferative properties of commercial Pelargonium sidoides tincture, with cell-cycle G0/G1 arrest and apoptosis in Jurkat leukaemia cells.

    Science.gov (United States)

    Pereira, Andreia; Bester, Megan; Soundy, Puffy; Apostolides, Zeno

    2016-09-01

    Context Pelargonium sidoides DC (Geraniaceae) is an important medicinal plant indigenous to South Africa and Lesotho. Previous studies have shown that root extracts are rich in polyphenolic compounds with antibacterial, antiviral and immunomodulatory activities. Little is known regarding the anticancer properties of Pelargonium sidoides extracts. Objective This study evaluates the anti-proliferative effects of a Pelargonium sidoides radix mother tincture (PST). Materials and methods The PST was characterized by LC-MS/MS. Anti-proliferative activity was evaluated in the pre-screen panel of the National Cancer Institute (NCI-H460, MCF-7 and SF-268) and the Jurkat leukaemia cell line at concentrations of 0-150 μg/mL. The effect on cell growth was determined with sulphorhodamine B and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays after 72 h. The effect on cell cycle and apoptosis induction in Jurkat cells was determined by flow cytometry with propidium iodide and Annexin V: fluorescein isothiocyanate staining. Results Dihydroxycoumarin sulphates, gallic acid as well as gallocatechin dimers and trimers were characterized in PST by mass spectrometry. Moderate anti-proliferative effects with GI50 values between 40 and 80 μg/mL were observed in the NCI-pre-screen panel. Strong activity observed with Jurkat cells with a GI50 value of 6.2 μg/mL, significantly better than positive control 5-fluorouracil (GI50 value of 9.7 μg/mL). The PST arrested Jurkat cells at the G0/G1 phase of the cell cycle and increased the apoptotic cells from 9% to 21%, while the dead cells increased from 4% to 17%. Conclusion We present evidence that P. sidoides has cancer cell type-specific anti-proliferative effects and may be a source of novel anticancer molecules.

  2. Commercializing light-duty plug-in/plug-out hydrogen-fuel-cell vehicles: "Mobile electricity" technologies, early California household markets, and innovation management

    Science.gov (United States)

    Williams, Brett David

    Starting from the premise that new consumer value must drive hydrogen-fuel-cell-vehicle (H2FCV) commercialization, a group of opportunities collectively called "Mobile Electricity" (Me-) is characterized. Me- redefines H2 FCVs as innovative products able to provide home recharging and mobile power, for example for tools, mobile activities, emergencies, and electric-grid-support services. To characterize such opportunities, this study first integrates and extends previous analyses of H2FCVs, plug-in hybrids, and vehicle-to-grid (V2G) power. It uses a new model to estimate zero-emission-power vs. zero-emission-driving tradeoffs, costs, and grid-support revenues for various electric-drive vehicle types and levels of infrastructure service. Next, the initial market potential for Me- enabled vehicles, such as H2FCVs and plug-in hybrids, is estimated by eliminating unlikely households from consideration for early adoption. 5.2 million of 33.9 million Californians in the 2000 Census live in households pre-adapted to Me-, 3.9 million if natural gas is required for home refueling. The possible sales base represented by this population is discussed. Several differences in demographic and other characteristics between the target market and the population as a whole are highlighted, and two issues related to the design of H2FCVs and their supporting infrastructure are discussed: vehicle range and home hydrogen refueling. These findings argue for continued investigation of this and similar target segments-which represent more efficient research populations for subsequent study by product designers and other decision-makers wishing to understand the early market dynamics facing Me- innovations. Next, Me-H2FCV commercialization issues are raised from the perspectives of innovation, product development, and strategic marketing. Starting with today's internalcombustion hybrids, this discussion suggests a way to move beyond the battery vs. fuel-cell zero-sum game and towards the

  3. The NASA Electronic Parts and Packaging (NEPP) Program: Roadmap for FY15 and Beyond and Recent Radiation Highlights

    Science.gov (United States)

    LaBel, Kenneth A.; Sampson, Michael J.

    2015-01-01

    This presentation is a NASA Electronic Parts and Packaging (NEPP) Program: Roadmap for FY15 and Beyond. This roadmap provides a snapshot for current plans and collaborations on testing and evaluation of electronics as well as a discussion of the technology selection approach.

  4. Consolidation and development roadmap of the EMI middleware

    Science.gov (United States)

    Kónya, B.; Aiftimiei, C.; Cecchi, M.; Field, L.; Fuhrmann, P.; Nilsen, J. K.; White, J.

    2012-12-01

    Scientific research communities have benefited recently from the increasing availability of computing and data infrastructures with unprecedented capabilities for large scale distributed initiatives. These infrastructures are largely defined and enabled by the middleware they deploy. One of the major issues in the current usage of research infrastructures is the need to use similar but often incompatible middleware solutions. The European Middleware Initiative (EMI) is a collaboration of the major European middleware providers ARC, dCache, gLite and UNICORE. EMI aims to: deliver a consolidated set of middleware components for deployment in EGI, PRACE and other Distributed Computing Infrastructures; extend the interoperability between grids and other computing infrastructures; strengthen the reliability of the services; establish a sustainable model to maintain and evolve the middleware; fulfil the requirements of the user communities. This paper presents the consolidation and development objectives of the EMI software stack covering the last two years. The EMI development roadmap is introduced along the four technical areas of compute, data, security and infrastructure. The compute area plan focuses on consolidation of standards and agreements through a unified interface for job submission and management, a common format for accounting, the wide adoption of GLUE schema version 2.0 and the provision of a common framework for the execution of parallel jobs. The security area is working towards a unified security model and lowering the barriers to Grid usage by allowing users to gain access with their own credentials. The data area is focusing on implementing standards to ensure interoperability with other grids and industry components and to reuse already existing clients in operating systems and open source distributions. One of the highlights of the infrastructure area is the consolidation of the information system services via the creation of a common information

  5. Technology Road-map Update for Generation IV Nuclear Energy Systems

    International Nuclear Information System (INIS)

    2014-01-01

    This Technology Road-map Update provides an assessment of progress made by the Generation IV International Forum (GIF) in the development of the six systems selected when the original Technology Road-map was published in 2002. More importantly, it provides an overview of the major R and D objectives and milestones for the coming decade, aiming to achieve the Generation IV goals of sustainability, safety and reliability, economic competitiveness, proliferation resistance and physical protection. Lessons learnt from the Fukushima Daiichi nuclear power plant accident are taken into account to ensure that Generation IV systems attain the highest levels of safety, with the development of specific safety design criteria that are applicable across the six systems. Accomplishing the ten-year R and D objectives set out in this new Road-map should allow the more advanced Generation IV systems to move towards the demonstration phase. (authors)

  6. Windows and Building Envelope Research and Development: A Roadmap for Emerging Technologies

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-02-01

    This Building Technologies Office (BTO) Research and Development (R&D) Roadmap identifies priority windows and building envelope R&D areas of interest. Cost and performance targets are identified for each key R&D area. The roadmap describes the technical and market challenges to be overcome, R&D activities and milestones, key stakeholders, and potential energy savings that could result if cost and performance targets are met. Methods for improving technology performance and specific strategies for reducing installed costs and mitigating any other market barriers, which would increase the likelihood of mass-market technology adoption, are identified. This roadmap is a useful resource for public and private decision makers evaluating and pursuing high-impact R&D focused on advancing next-generation energy efficient windows and building envelope technologies.

  7. Roadmaps for the Development of Technologies Related to Danish Wave Power Systems

    DEFF Research Database (Denmark)

    Nielsen, Kim; Krogh, Jan; Brodersen, H. J.

    2015-01-01

    of coordinating and focus the research, development and test activities. The aim is that the resources (financial and know-how) are used appropriately and with the greatest possible progress. Within each of the 4 areas, the starting point is based on the state of the art technology, and the roadmaps outline what......The Danish Partnership for Wave Power was established in 2011 under the project "New strategy for wave power through industrial partnership" [1] funded by the Danish Energy Technology Development and Demonstration Program. The core of this partnership is nine active Danish wave energy developers...... seconded by offshore industry, and research institutions. The Danish Partnership for Wave Power has further been consolidated through the follow-on Roadmap project described in this paper. The roadmap project has in detail investigated how the four most common technology areas for wave power developers can...

  8. Fluoride Salt-Cooled High-Temperature Reactor Technology Development and Demonstration Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Holcomb, David Eugene [ORNL; Flanagan, George F [ORNL; Mays, Gary T [ORNL; Pointer, William David [ORNL; Robb, Kevin R [ORNL; Yoder Jr, Graydon L [ORNL

    2013-11-01

    Fluoride salt-cooled High-temperature Reactors (FHRs) are an emerging reactor class with potentially advantageous performance characteristics, and fully passive safety. This roadmap describes the principal remaining FHR technology challenges and the development path needed to address the challenges. This roadmap also provides an integrated overview of the current status of the broad set of technologies necessary to design, evaluate, license, construct, operate, and maintain FHRs. First-generation FHRs will not require any technology breakthroughs, but do require significant concept development, system integration, and technology maturation. FHRs are currently entering early phase engineering development. As such, this roadmap is not as technically detailed or specific as would be the case for a more mature reactor class. The higher cost of fuel and coolant, the lack of an approved licensing framework, the lack of qualified, salt-compatible structural materials, and the potential for tritium release into the environment are the most obvious issues that remain to be resolved.

  9. A covenant of halflings? developing a roadmap for the european urban transport goal

    DEFF Research Database (Denmark)

    Gudmundsson, Henrik; Schippl, Jens; Anderton, Karen

    2015-01-01

    In the 2011 Transport Policy White Paper, the European Commission introduced ten goals for a more competitive and resource efficient transport system. One of the goal concerns urban transport, with the dual targets: “To halve the use of ‘conventionally-fuelled’ cars in urban transport by 2030......; and to phase them out by 2050; and “To achieve ‘essentially CO2- free city logistics’ in major urban centres by 2030.” This paper describes how the EU FP7 project TRANSFORUM conducted a stakeholder-driven process to produce a roadmap for the urban transport goal. A main conclusion was that the implementation...... of a roadmap for urban transport needs to adopt a broad and open approach, given the diversity among member states and cities across Europe. Also it was found that replacing conventional vehicles and fuels is an important but not sufficient strategy to reach the goal. A roadmap to reach towards the ‘halving...

  10. Impact of commercial cigarette smoke condensate on brain tissue co-cultured with astrocytes and blood-brain barrier endothelial cells.

    Science.gov (United States)

    Lee, Seon-Bong; Kim, Ju-Hyeong; Cho, Myung-Haing; Choe, Eun-Sang; Kim, Kwang-Sik; Shim, Soon-Mi

    2017-01-01

    The purpose of the current study was to investigate the effect of two commercial cigarette smoke condensates (CCSC) on oxidative stress and cell cytotoxicity in human brain (T98G) or astrocytes (U-373 MG) in the presence of human brain microvascular endothelial cells (HBMEC). Cell viability of mono-culture of T98G or U-373 MG was markedly decreased in a concentration-dependent manner, and T98G was more susceptible than U-373 MG to CCSC exposure. Cytotoxicity was less prominent when T98G was co-cultured with HBMEC than when T98G was co-cultured with U-373 MG. Significant reduction in trans-epithelial electric resistance (TEER), a biomarker of cellular integrity was noted in HBMEC co-cultured with T98G (HBMEC-T98G co-culture) and U-373 MG co-cultured with T98G (U-373 MG-T98G co-culture) after 24 or 48 hr CCSC exposure, respectively. TEER value of U-373 MG co-cultured with T98G (79-84%) was higher than HBMEC co-cultured with T98G (62-63%) within 120-hr incubation with CCSC. Reactive oxygen species (ROS) generated by CCSC in mono-culture of T98G and U-373 MG reached highest levels at 4 and 16 mg/ml, respectively. ROS production by T98G fell when co-cultured with HBMEC or U-373MG. These findings suggest that adverse consequences of CCSC treatment on brain cells may be protected by blood-brain barrier or astrocytes, but with chronic exposure toxicity may be worsened due to destruction of cellular integrity.

  11. Low Molecular Weight Fraction of Commercial Human Serum Albumin Induces Morphologic and Transcriptional Changes of Bone Marrow-Derived Mesenchymal Stem Cells.

    Science.gov (United States)

    Bar-Or, David; Thomas, Gregory W; Rael, Leonard T; Gersch, Elizabeth D; Rubinstein, Pablo; Brody, Edward

    2015-08-01

    Osteoarthritis (OA) is the most common chronic disease of the joint; however, the therapeutic options for severe OA are limited. The low molecular weight fraction of commercial 5% human serum albumin (LMWF5A) has been shown to have anti-inflammatory properties that are mediated, in part, by a diketopiperazine that is present in the albumin preparation and that was demonstrated to be safe and effective in reducing pain and improving function when administered intra-articularly in a phase III clinical trial. In the present study, bone marrow-derived mesenchymal stem cells (BMMSCs) exposed to LMWF5A exhibited an elongated phenotype with diffuse intracellular F-actin, pronounced migratory leading edges, and filopodia-like projections. In addition, LMWF5A promoted chondrogenic condensation in "micromass" culture, concurrent with the upregulation of collagen 2α1 mRNA. Furthermore, the transcription of the CXCR4-CXCL12 axis was significantly regulated in a manner conducive to migration and homing. Several transcription factors involved in stem cell differentiation were also found to bind oligonucleotide response element probes following exposure to LMWF5A. Finally, a rapid increase in PRAS40 phosphorylation was observed following treatment, potentially resulting in the activation mTORC1. Proteomic analysis of synovial fluid taken from a preliminary set of patients indicated that at 12 weeks following administration of LMWF5A, a microenvironment exists in the knee conducive to stem cell infiltration, self-renewal, and differentiation, in addition to indications of remodeling with a reduction in inflammation. Taken together, these findings imply that LMWF5A treatment may prime stem cells for both mobilization and chondrogenic differentiation, potentially explaining some of the beneficial effects achieved in clinical trials. ©AlphaMed Press.

  12. Isolation and genetic characterization of human coronavirus NL63 in primary human renal proximal tubular epithelial cells obtained from a commercial supplier, and confirmation of its replication in two different types of human primary kidney cells.

    Science.gov (United States)

    Lednicky, John A; Waltzek, Thomas B; McGeehan, Elizabeth; Loeb, Julia C; Hamilton, Sara B; Luetke, Maya C

    2013-06-27

    Cryopreserved primary human renal proximal tubule epithelial cells (RPTEC) were obtained from a commercial supplier for studies of Simian virus 40 (SV40). Within twelve hrs after cell cultures were initiated, cytoplasmic vacuoles appeared in many of the RPTEC. The RPTEC henceforth deteriorated rapidly. Since SV40 induces the formation of cytoplasmic vacuoles, this batch of RPTEC was rejected for the SV40 study. Nevertheless, we sought the likely cause(s) of the deterioration of the RPTEC as part of our technology development efforts. Adventitious viruses in the RPTEC were isolated and/or detected and identified by isolation in various indicator cell lines, observation of cytopathology, an immunoflurorescence assay, electron microscopy, PCR, and sequencing. Cytomegalovirus (CMV) was detected in some RPTEC by cytology, an immunofluorescence assay, and PCR. Human Herpesvirus 6B was detected by PCR of DNA extracted from the RPTEC, but was not isolated. Human coronavirus NL63 was isolated and identified by RT-PCR and sequencing, and its replication in a fresh batch of RPTEC and another type of primary human kidney cells was confirmed. At least 3 different adventitious viruses were present in the batch of contaminated RPTEC. Whereas we are unable to determine whether the original RPTEC were pre-infected prior to their separation from other kidney cells, or had gotten contaminated with HCoV-NL63 from an ill laboratory worker during their preparation for commercial sale, our findings are a reminder that human-derived biologicals should always be considered as potential sources of infectious agents. Importantly, HCoV-NL63 replicates to high titers in some primary human kidney cells.

  13. The Forest Fibre Industry. 2050 Roadmap to a low-carbon bio-economy

    Energy Technology Data Exchange (ETDEWEB)

    Presas, T.; Mensink, M.

    2011-11-15

    In March 2011, the European Commission published a 'Roadmap for moving to a competitive low-carbon economy in 2050', a discussion document to explore the future of climate change policy. The document models pathways towards 2050 and the possible contribution of different sectors. It will be followed by an 'energy roadmap' towards the end of 2011 and will be combined with other roadmaps on, for example, the future of transport. In time, it will lead to a new 'climate change and energy package'. The outcome will be crucial for Europe's pulp, paper and wood products industries, which operate at the crossroads of renewable energy policy, emission trading, industrial and raw material policies. Climate change policy, too, has a major influence on the future of these sectors. After all, climate change policy is, essentially, industrial policy. This roadmap attempts to lay out the future of the forest fibre industry - the pulp, paper and board and wood products sectors combined - and its potential to meet future consumer demands, stay competitive and deliver a CO2 emission reduction in line with the modelled overall industrial reduction of 80% by 2050, compared to 1990 levels. The roadmap explores the technical, financial and resource constraints that lie ahead, and the policy framework that will be needed to tackle them. Our roadmap is an exploration into the future. The CO2 reduction envisaged can only be achieved when the right policy framework is in place. The sector can play its part as long as it remains profitable and attractive to investments, keeps access to fibre and other raw materials and receives enough support to bring breakthrough technologies within reach.

  14. Biological Response of Human Bone Marrow-Derived Mesenchymal Stem Cells to Commercial Tantalum Coatings with Microscale and Nanoscale Surface Topographies

    Science.gov (United States)

    Skoog, Shelby A.; Kumar, Girish; Goering, Peter L.; Williams, Brian; Stiglich, Jack; Narayan, Roger J.

    2016-06-01

    Tantalum is a promising orthopaedic implant coating material due to its robust mechanical properties, corrosion resistance, and excellent biocompatibility. Previous studies have demonstrated improved biocompatibility and tissue integration of surface-treated tantalum coatings compared to untreated tantalum. Surface modification of tantalum coatings with biologically inspired microscale and nanoscale features may be used to evoke optimal tissue responses. The goal of this study was to evaluate commercial tantalum coatings with nanoscale, sub-microscale, and microscale surface topographies for orthopaedic and dental applications using human bone marrow-derived mesenchymal stem cells (hBMSCs). Tantalum coatings with different microscale and nanoscale surface topographies were fabricated using a diffusion process or chemical vapor deposition. Biological evaluation of the tantalum coatings using hBMSCs showed that tantalum coatings promote cellular adhesion and growth. Furthermore, hBMSC adhesion to the tantalum coatings was dependent on surface feature characteristics, with enhanced cell adhesion on sub-micrometer- and micrometer-sized surface topographies compared to hybrid nano-/microstructures. Nanostructured and microstructured tantalum coatings should be further evaluated to optimize the surface coating features to promote osteogenesis and enhance osseointegration of tantalum-based orthopaedic implants.

  15. The place of digital technology on the IEA's energy road-maps

    International Nuclear Information System (INIS)

    Ben-Naceur, Kamel

    2017-01-01

    The International Energy Agency (IEA) has drafted road-maps for the next four decades in collaboration with public and private producers and consumers of energy. For each type of energy, these road-maps indicate the key elements for compliance with the objectives of the Paris Climate Agreement. They emphasize the role of digital technology, in particular smart grids, in the transition toward a more digital and more intelligent energy system. The conditions necessary for successfully transforming this sector are mapped out, while attention is called to the risks inherent in this transition

  16. Research and Development Roadmap For Next-Generation Low-Global Warming Potential Refrigerants

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-07-01

    The Department of Energy commissioned this roadmap to establish a set of high-priority research and development (R&D) activities that will accelerate the transition to low-GWP refrigerants across the entire heating, ventilation, air-conditioning and refrigeration (HVAC&R) industry. The schedule of R&D activities occurs within an accelerated five-year timeframe, and covers several prominent equipment types. The roadmap is organized around four primary objectives to: assess and mitigate safety risks, characterize refrigerant properties, understand efficiency and environmental tradeoffs, and support new refrigerant and equipment development.

  17. Towards nZEB - Some Examples of National Requirements and Roadmaps

    DEFF Research Database (Denmark)

    Jagemar, Lennart; Schmidt, Michael; Allard, Francis

    2011-01-01

    in the definition of energy performance in [kWh/m2,a]. Many countries have prepared long term roadmaps with detailed targets, Figure 1. Such roadmaps help the industry to be prepared and committed to the targets. For example, in Norway, zero energy buildings are expected in 2027, but in UK carbon neutral buildings...... are different. Primary energy, delivered energy, various energy frames and even CO2 emissions are used. Such differences in regulations have a significant effect on the building industry, and complicate manufacturing, sales, installation, construction and design of buildings in the common market area...

  18. Synthesizing R&D Data: Experiences from the Integrated Manufacturing Technology Roadmap (IMTR) Project

    Energy Technology Data Exchange (ETDEWEB)

    merrell, m.a.

    1999-05-05

    IMTR is a tremendous undertaking to assess the current state and future needs of Manufacturing Technology R&D. A follow-on project to the roadmaps is the development and populating of a Gap Analysis database containing current R&D abstracts related to the roadmaps' technical elements. Efficiently identifying the R&D projects within scope presents many travails of synthesizing data from across a wide spectrum. Challenges to this project were directly proportional to the lack of single-source data collections.

  19. Identification of nanoscale ingredients in commercial food products and their induction of mitochondrially mediated cytotoxic effects on human mesenchymal stem cells.

    Science.gov (United States)

    Athinarayanan, Jegan; Alshatwi, Ali A; Periasamy, Vaiyapuri S; Al-Warthan, Abdulrahman A

    2015-02-01

    Titanium dioxide (E171) and silicon dioxide (E551) are common additives found in food products, personal-care products, and many other consumer products used in daily life. Recent studies have reported that these food additives (manufactured E171 and E551) contain nanosized particles of less than 100 nm. However, the particle size distribution and morphology of added TiO2 and SiO2 particles are not typically stated on the package label. Furthermore, there is an increasing debate regarding health and safety concerns related to the use of synthetic food additives containing nanosized ingredients in consumer products. In this study, we identified the size and morphology of TiO2 and SiO2 particles in commercially available food products by using transmission electron microscope (TEM). In addition, the in vitro toxicological effects of E171 and E551 on human mesenchymal stem cells (hMSCs), an adult stem cell-based model, were assessed using the MTT assay and a flow cytometry-based JC-1 assay. Our TEM results confirmed the presence of nanoscale ingredients in food products, and the in vitro toxicology results indicated that the nanoscale E171 and E551 ingredients induced dose-dependent cytotoxicity, changes in cellular morphology, and the loss of mitochondrial trans-membrane potential in hMSCs. These preliminary results clearly demonstrated that the nanoscale E171 and E551 particles had adverse effects on hMSCs by inducing oxidative stress-mediated cell death. Accordingly, further studies are needed to identify the specific pathway involved, with an emphasis on differential gene expression in hMSCs. © 2015 Institute of Food Technologists®

  20. A Roadmap for Tick-Borne Flavivirus Research in the “Omics” Era

    Directory of Open Access Journals (Sweden)

    Jeffrey M. Grabowski

    2017-12-01

    Full Text Available Tick-borne flaviviruses (TBFs affect human health globally. Human vaccines provide protection against some TBFs, and antivirals are available, yet TBF-specific control strategies are limited. Advances in genomics offer hope to understand the viral complement transmitted by ticks, and to develop disruptive, data-driven technologies for virus detection, treatment, and control. The genome assemblies of Ixodes scapularis, the North American tick vector of the TBF, Powassan virus, and other tick vectors, are providing insights into tick biology and pathogen transmission and serve as nucleation points for expanded genomic research. Systems biology has yielded insights to the response of tick cells to viral infection at the transcript and protein level, and new protein targets for vaccines to limit virus transmission. Reverse vaccinology approaches have moved candidate tick antigenic epitopes into vaccine development pipelines. Traditional drug and in silico screening have identified candidate antivirals, and target-based approaches have been developed to identify novel acaricides. Yet, additional genomic resources are required to expand TBF research. Priorities include genome assemblies for tick vectors, “omic” studies involving high consequence pathogens and vectors, and emphasizing viral metagenomics, tick-virus metabolomics, and structural genomics of TBF and tick proteins. Also required are resources for forward genetics, including the development of tick strains with quantifiable traits, genetic markers and linkage maps. Here we review the current state of genomic research on ticks and tick-borne viruses with an emphasis on TBFs. We outline an ambitious 10-year roadmap for research in the “omics era,” and explore key milestones needed to accomplish the goal of delivering three new vaccines, antivirals and acaricides for TBF control by 2030.

  1. Roadmap of ultrafast x-ray atomic and molecular physics

    Science.gov (United States)

    Young, Linda; Ueda, Kiyoshi; Gühr, Markus; Bucksbaum, Philip H.; Simon, Marc; Mukamel, Shaul; Rohringer, Nina; Prince, Kevin C.; Masciovecchio, Claudio; Meyer, Michael; Rudenko, Artem; Rolles, Daniel; Bostedt, Christoph; Fuchs, Matthias; Reis, David A.; Santra, Robin; Kapteyn, Henry; Murnane, Margaret; Ibrahim, Heide; Légaré, François; Vrakking, Marc; Isinger, Marcus; Kroon, David; Gisselbrecht, Mathieu; L'Huillier, Anne; Wörner, Hans Jakob; Leone, Stephen R.

    2018-02-01

    X-ray free-electron lasers (XFELs) and table-top sources of x-rays based upon high harmonic generation (HHG) have revolutionized the field of ultrafast x-ray atomic and molecular physics, largely due to an explosive growth in capabilities in the past decade. XFELs now provide unprecedented intensity (1020 W cm-2) of x-rays at wavelengths down to ˜1 Ångstrom, and HHG provides unprecedented time resolution (˜50 attoseconds) and a correspondingly large coherent bandwidth at longer wavelengths. For context, timescales can be referenced to the Bohr orbital period in hydrogen atom of 150 attoseconds and the hydrogen-molecule vibrational period of 8 femtoseconds; wavelength scales can be referenced to the chemically significant carbon K-edge at a photon energy of ˜280 eV (44 Ångstroms) and the bond length in methane of ˜1 Ångstrom. With these modern x-ray sources one now has the ability to focus on individual atoms, even when embedded in a complex molecule, and view electronic and nuclear motion on their intrinsic scales (attoseconds and Ångstroms). These sources have enabled coherent diffractive imaging, where one can image non-crystalline objects in three dimensions on ultrafast timescales, potentially with atomic resolution. The unprecedented intensity available with XFELs has opened new fields of multiphoton and nonlinear x-ray physics where behavior of matter under extreme conditions can be explored. The unprecedented time resolution and pulse synchronization provided by HHG sources has kindled fundamental investigations of time delays in photoionization, charge migration in molecules, and dynamics near conical intersections that are foundational to AMO physics and chemistry. This roadmap coincides with the year when three new XFEL facilities, operating at Ångstrom wavelengths, opened for users (European XFEL, Swiss-FEL and PAL-FEL in Korea) almost doubling the present worldwide number of XFELs, and documents the remarkable progress in HHG capabilities since

  2. Roadmap for human resources for expanded Indian nuclear industry

    Energy Technology Data Exchange (ETDEWEB)

    Singh, R.K. [Bhabha Atomic Research Centre, Mumbai (India); Indian Nuclear Society (India); Srinivasan, G.R.; Goyal, O.P. [Bhabha Atomic Research Centre, Mumbai (India)

    2011-07-01

    This paper deals with detailed requirement of human resources for all phases of nuclear power plant, for the manufacturing sector and the probable roadmap for achieving India's target. The accident in Fukushima has brought out that only nuclear power that avoids being a threat to the health and safety of the population and the environmental will be acceptable to the society and for this to be achieved human resources could be a single major contributor. India has ambitious plan of achieving 20,000MW by 2020 and 63,000MW by 2050. It is felt out of the three resources men, material and money; the critical shortage would be human resources both in quality and quantity. As per IAEA report (Publication of 2008 edition of energy, electricity and nuclear power estimates for the period of 2030), nuclear capacity must grow to at least 1.8 times current capacity by 2030 if global temperature rises are to be kept at 2°C. Objective of recruiting and training human resources for Indian Industry can be as follows: a) For catering domestic market. b) For catering international market later on for nuclear industries outside India. As India will be an important future international player. The above would require a multiplication of human resources by nearly seven times. In addition it has to be wholesome covering all levels and all skills and all disciplines and stages covering the whole nuclear cycle including regulators. Human resources are required for design and engineering, construction, commissioning, operation, manufacturing and for support services. The manpower for these has to be trained to achieve high quality of nuclear standards. Presently Indian Department of Atomic Energy(DAE) runs several training schools giving one year Post Graduate, tailor made courses. This needs to be multiplied by Joint efforts. Training should be on 'SAT (Systematic Approach to Training)' methodology to ensure focussed, specific, needed to culminate in safe, reliable and

  3. Roadmap for human resources for expanded Indian nuclear industry

    International Nuclear Information System (INIS)

    Singh, R.K.; Srinivasan, G.R.; Goyal, O.P.

    2011-01-01

    This paper deals with detailed requirement of human resources for all phases of nuclear power plant, for the manufacturing sector and the probable roadmap for achieving India's target. The accident in Fukushima has brought out that only nuclear power that avoids being a threat to the health and safety of the population and the environmental will be acceptable to the society and for this to be achieved human resources could be a single major contributor. India has ambitious plan of achieving 20,000MW by 2020 and 63,000MW by 2050. It is felt out of the three resources men, material and money; the critical shortage would be human resources both in quality and quantity. As per IAEA report (Publication of 2008 edition of energy, electricity and nuclear power estimates for the period of 2030), nuclear capacity must grow to at least 1.8 times current capacity by 2030 if global temperature rises are to be kept at 2°C. Objective of recruiting and training human resources for Indian Industry can be as follows: a) For catering domestic market. b) For catering international market later on for nuclear industries outside India. As India will be an important future international player. The above would require a multiplication of human resources by nearly seven times. In addition it has to be wholesome covering all levels and all skills and all disciplines and stages covering the whole nuclear cycle including regulators. Human resources are required for design and engineering, construction, commissioning, operation, manufacturing and for support services. The manpower for these has to be trained to achieve high quality of nuclear standards. Presently Indian Department of Atomic Energy(DAE) runs several training schools giving one year Post Graduate, tailor made courses. This needs to be multiplied by Joint efforts. Training should be on 'SAT (Systematic Approach to Training)' methodology to ensure focussed, specific, needed to culminate in safe, reliable and viable operation of

  4. Applying a Commercial Atomic Force Microscope for Scanning Near-field Optical Microscopy Techniques and Investigation of Cell-cell Signaling

    Science.gov (United States)

    Lopez Ayon, Gabriela Monserratt

    The field of research of this thesis is Condensed Matter Physics applied to Biology. Specifically it describes the development of different Atomic Force Microscopy techniques and tools towards the study of living cells in physiological solution. Particular interest is put into the understanding of the influence of noise in the determination of ordered liquid layers above a mica surface - as work towards the study of the role of water and ions in biological processes - and the influence of "diving bell" to boost the Q factor and allow stable imaging and force spectroscopy with tips based on Scanning Near-field Optical Microscopy [LeDue, 2010 and LeDue, 2008]. By combining SNOM techniques as a local illumination method (and thus avoiding photo bleaching of individual molecules) and high resolution AFM techniques we will be able to investigate mechano-transduction and associated signaling in living cells and individual proteins.

  5. U.S. Department of Energy Office of Indian Energy Policy and Programs: Strategic Roadmap 2025

    Energy Technology Data Exchange (ETDEWEB)

    2016-03-01

    The U.S. Department of Energy Office of Indian Energy Policy and Programs Strategic Roadmap 2025 outlines strategic target areas and tactical actions to ensure the Office remains aligned with its congressional mandates and DOE goals, and that it can be responsive to changing conditions in Indian Country and the nation.

  6. The european hematology association roadmap for european hematology research : A consensus document

    NARCIS (Netherlands)

    A. Engert (Andreas); C.L. Balduini (Carlo); A. Brand (Anneke); B. Coiffier (Bertrand); C. Cordonnier (Charlotte); H. Döhner (Hartmut); De Wit, T.D. (Thom Duyvené); Eichinger, S. (Sabine); W.E. Fibbe (Willem); Green, T. (Tony); De Haas, F. (Fleur); A. Iolascon (Achille); T. Jaffredo (Thierry); F. Rodeghiero (Francesco); G. Salles (Gilles); J.J. Schuringa (Jan Jacob)

    2016-01-01

    textabstractThe European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European

  7. The development of an evidence-based teledermatology scale-up framework and roadmap

    CSIR Research Space (South Africa)

    Walters, Laticha EM

    2017-12-01

    Full Text Available the public health system at a disadvantage in making the dermatology referral pathway neither effective nor efficient. This paper presents the development of an evidenced-based Teledermatology Scale-up Framework (TDSF) and supporting roadmap to assist...

  8. NEA International Workshop on the Nuclear Innovation Road-map - NI2050. Workshop proceedings

    International Nuclear Information System (INIS)

    Ait Abderrahim, Hamid; Fernandez Fernandez, Alberto; Van Walle, Eric; Speranzini, Robert; Zezula, Lubor; Puska, Eija Karita; Tuomisto, Harri; Al Mazouzi, Abderrahim; Bazile, Fanny; Cordier, Pierre-Yves; Wahide, Carole; Tromm, Th. Walter; Horvath, Akos; Agostini, Pietro; Ambrosini, Walter; Kamide, Hideki; Nakatsuka, Toru; Sagayama, Yutaka; Tsujimoto, Kazufumi; Jeong, Ik; LEE, Gye Seok; Roelofs, Ferry; Van Der Lugt, Hermen; Wrochna, Grzegorz; Alekseev, Pavel; Andreeva-Andrievskaya, Lyudmila N.; Liska, Peter; Cizelj, Leon; Castelao Lopez, Carlos; Zimmermann, Martin; Rayment, Fiona; Pasamehmetoglu, Kemal; Martin Ramos, Manuel; Schmitz, Bruno; Monti, Stefano; Bignan, Gilles; Mcgrath, Margaret; Caron-Charles, Marylise; Magwood, William IV; Ha, Jaejoo; Deffrennes, Marc; Paillere, Henri; Noh, Jae Man; Gulliford, Jim; Breest, Axel; Matsumoto, Kiyoshi; Lebedev, Vladimir

    2015-07-01

    The two-day workshop held at the OECD Headquarters in Paris on 7-8 July 2015, brought together some of the leading experts in the field of nuclear fission research, development and demonstration. The purpose was to launch the NEA Nuclear Innovation 2050 Initiative, aiming, after a first survey phase, at producing a road-map of main priority research programs and infrastructures necessary to support the role nuclear energy may play in the low carbon power sector of the future. This might then further lead to some ad-hoc co-operation frameworks that help to effectively implement key priorities coming out of the road-mapping. The workshop was organised into the following five sessions: 1 - Opening session on NI2050: vision and main objectives; 2 - National presentations on nuclear fission research and innovation activities (programs, infrastructures, budgets); 3 - Presentations on some existing international nuclear fission road-maps and co-operation frameworks; 4 - Defining the way forward for NI2050: survey, road-mapping and priorities and co-operation; 5 - Open discussion. This document gathers the available presentations given at this workshop

  9. NASA Strategic Roadmap: Origin, Evolution, Structure, and Destiny of the Universe

    Science.gov (United States)

    White, Nicholas E.

    2005-01-01

    The NASA strategic roadmap on the Origin, Evolution, Structure and Destiny of the Universe is one of 13 roadmaps that outline NASA s approach to implement the vision for space exploration. The roadmap outlines a program to address the questions: What powered the Big Bang? What happens close to a Black Hole? What is Dark Energy? How did the infant universe grow into the galaxies, stars and planets, and set the stage for life? The roadmap builds upon the currently operating and successful missions such as HST, Chandra and Spitzer. The program contains two elements, Beyond Einstein and Pathways to Life, performed in three phases (2005-2015, 2015-2025 and >2025) with priorities set by inputs received from reviews undertaken by the National Academy of Sciences and technology readiness. The program includes the following missions: 2005-2015 GLAST, JWST and LISA; 2015-2025 Constellation-X and a series of Einstein Probes; and >2025 a number of ambitious vision missions which will be prioritized by results from the previous two phases.

  10. A roadmap for evolving towards optical intra-data-center networks

    DEFF Research Database (Denmark)

    Dittmann, Lars; Fagertun, Anna Manolova; Kamchevska, Valerija

    2016-01-01

    The first part of this paper focuses on presenting an updated view on the state of the art in data center networks. The European project COSIGN has provided industrial optical data center network roadmaps, strategies and a techno-economic analysis of the involved industrial partners’ value...

  11. Clean Cities Roadmap : A resource for developing, implementing, and sustaining your clean cities program

    Science.gov (United States)

    2001-08-01

    This roadmap explains how your community can join forces with the nationwide network of Clean Cities to increase the use of alternative fuels and alternative fuel vehicles (AFVs). You will learn how the U.S. Department of Energy (DOE) can help your c...

  12. Assistive Robotics in Robotics for healthcare, roadmap study for the EC

    NARCIS (Netherlands)

    Gelderblom, G.J.; Wilt, M. de; Cremers, G.; Rensma, A.

    2009-01-01

    To gain understanding in the current status of Robotics in healthcare the European Commission issued a roadmap study into this domain. This paper reports on the main characteristics and results of this study. The study covered the wide domain of Healthcare and in this paper the domains relevant for

  13. Rehabilitation robotics in robotics for healthcare ; a roadmap study for the European Commission

    NARCIS (Netherlands)

    Gelderblom, G.J.; Wilt, M.de; Cremers, G.; Rensma, A.R.

    2009-01-01

    To gain understanding in the current status of Robotics in healthcare the European Commission issued a roadmap study into this domain. This paper reports on the main characteristics and results of this study. The study covered the wide domain of Healthcare and in this paper the domains relevant for

  14. Commercial alkaline earth boroaluminosilicate glasses for sealing solid oxide cell stacks. Part I: Development of glass-ceramic microstructure and thermomechanical properties

    DEFF Research Database (Denmark)

    Agersted, Karsten; Balic-Zunic, Tonci

    2017-01-01

    was developed over ~1000 hours at 800°C, depends mainly on the formation of cristobalite and quartz as well as the presence of a residual glass phase. The glass ceramic sealant appears relatively stable over time, except for a slow transition of cristobalite to quartz, and can possibly show self......Sealing performance in solid oxide cell (SOC) stacks and the devitrification process of commercially available alkaline earth boroaluminosilicate glasses containing 48‐61 mol% SiO2, 18‐28 mol% CaO, 1‐7 mol% MgO, 7‐10 mol% Al2O3, 1‐11 mol% B2O3 plus minor amounts of Na2O, K2O, FeO, and TiO2 were...... investigated and quantified through analysis of phase assemblages as function of heat treatments above the glass transition temperatures using the electron microprobe and powder X‐ray diffraction. For two of these glasses devitrification behavior was compared to the devitrification behavior of similar glasses...

  15. Advanced Combustion and Emission Control Technical Team Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    The Advanced Combustion and Emission Control (ACEC) Technical Team is focused on removing technical barriers to the commercialization of advanced, high-efficiency, emission-compliant internal combustion (IC) engines for light-duty vehicle powertrains (i.e., passenger car, minivan, SUV, and pickup trucks).

  16. Road-map to successful implementation of geological disposal in the EU

    International Nuclear Information System (INIS)

    Patrakka, Eero

    2010-01-01

    In the conclusions from its first meeting in Bratislava (2007), the European Nuclear Energy Forum (ENEF) identified the management of spent fuel and radioactive waste as an important subject to be looked into with the objective 'to encourage Member States and industry to swiftly implement adequate nuclear waste disposal facilities, in particular deep geological repositories for high level waste'. To this end the Sub-Working Group 'Waste Management' (SWG-WM) was created in the context of the ENEF Working Group 'Risks'. As a first task, the SWG-WM was requested to compile a road-map that includes the essential elements of what is required at national level to foster the implementation of geological disposal for high level waste and spent fuel. In October 2009, a 'Road-map to Successful Implementation of Geological Disposal in the EU' was endorsed. The aim of this document is to provide guidance to EU Member States that are starting out or are at an early stage on the decades-long process leading towards the implementation of geological repositories for high level radioactive wastes or spent nuclear fuel, if this is deemed to be a waste. The guidance is based to a large extent on the positive progress that has been made in a number of Member States. Small and new nuclear states may take a long time to reach such a position - but a strong message of this Road-map is that the process should be initiated as soon as possible. The Road-map is intended to be generic enough to be applicable to all Member States, independently of their current position; the national Road-maps to be developed should be compatible with this, but will differ in the specifics of approach and of timing. (authors)

  17. Technology Roadmaps - Electric and plug-in hybrid electric vehicles (EV/PHEV)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-06-15

    The mass deployment of electric and plug-in hybrid electric vehicles (EVs and PHEVs) that rely on low greenhouse gas (GHG) emission electricity generation has great potential to significantly reduce the consumption of petroleum and other high CO2-emitting transportation fuels. The vision of the Electric and Plug-in Hybrid (EV/PHEV) Vehicles Roadmap is to achieve by 2050 the widespread adoption and use of EVs and PHEVs, which together represent more than 50% of annual LDV (light duty vehicle) sales worldwide. In addition to establishing a vision, this roadmap sets strategic goals to achieve it, and identifies the steps that need to be taken to accomplish these goals. This roadmap also outlines the roles and collaboration opportunities for different stakeholders and shows how government policy can support the overall achievement of the vision. The strategic goals for attaining the widespread adoption and use of EVs and PHEVs worldwide by 2050 cover the development of the EV/PHEV market worldwide through 2030 and involve targets that align with global targets to stabilise GHG concentrations. These technology-specific goals include the following: Set targets for electric-drive vehicle sales; Develop coordinated strategies to support the market introduction of electric-drive vehicles; Improve industry understanding of consumer needs and behaviours; Develop performance metrics for characterising vehicles; Foster energy storage RD and D initiatives to reduce costs and address resource-related issues; and, Develop and implement recharging infrastructure. The roadmap outlines additional recommendations that must be considered in order to successfully meet the technology milestones and strategic goals. These recommendations include the following: Use a comprehensive mix of policies that provide a clear framework and balance stakeholder interests; Engage in international collaboration efforts; and, Address policy and industry needs at a national level. The IEA will work in an

  18. Roadmapping - A Tool for Resolving Science and Technology Issues Related to Processing, Packaging, and Shipping Nuclear Materials and Waste

    Energy Technology Data Exchange (ETDEWEB)

    Luke, Dale Elden; Dixon, Brent Wayne; Murphy, James Anthony

    2002-06-01

    Roadmapping is an effective methodology to identify and link technology development and deployment efforts to a program's or project's needs and requirements. Roadmapping focuses on needed technical support to the baselines (and to alternatives to the baselines) where the probability of success is low (high uncertainty) and the consequences of failure are relatively high (high programmatic risk, higher cost, longer schedule, or higher ES&H risk). The roadmap identifies where emphasis is needed, i.e., areas where investments are large, the return on investment is high, or the timing is crucial. The development of a roadmap typically involves problem definition (current state versus the desired state) and major steps (functions) needed to reach the desired state. For Nuclear Materials (NM), the functions could include processing, packaging, storage, shipping, and/or final disposition of the material. Each function is examined to determine what technical development would be needed to make the function perform as desired. This requires a good understanding of the current state of technology and technology development and validation activities to ensure the viability of each step. In NM disposition projects, timing is crucial! Technology must be deployed within the project window to be of value. Roadmaps set the stage to keep the technology development and deployment focused on project milestones and ensure that the technologies are sufficiently mature when needed to mitigate project risk and meet project commitments. A recent roadmapping activity involved a 'cross-program' effort, which included NM programs, to address an area of significant concern to the Department of Energy (DOE) related to gas generation issues, particularly hydrogen. The roadmap that was developed defined major gas generation issues within the DOE complex and research that has been and is being conducted to address gas generation concerns. The roadmap also provided the basis

  19. Strategic Roadmap for the U.S. Geoscience Information Network

    Science.gov (United States)

    Allison, M. L.; Gallagher, K. T.; Richard, S. M.; Hutchison, V. B.

    2012-04-01

    An external advisory working group has prepared a 5-year strategic roadmap for the U.S. Geoscience Information Network (USGIN). USGIN is a partnership of the Association of American State Geologists (AASG) and the U.S. Geological Survey (USGS), who formally agreed in 2007 to develop a national geoscience information framework that is distributed, interoperable, uses open source standards and common protocols, respects and acknowledges data ownership, fosters communities of practice to grow, and develops new Web services and clients. The intention of the USGIN is to benefit the geological surveys by reducing the cost of online data publication and access provision, and to benefit society through easier (lower cost) access to public domain geoscience data. This information supports environmental planning, resource-development, hazard mitigation design, and decision-making. USGIN supposes that sharing resources for system development and maintenance, standardizing data discovery and creating better access mechanisms, causes cost of data access and maintenance to be reduced. Standardization in a wide variety of business domains provides economic benefits that range between 0.2 and 0.9% of the gross national product. We suggest that the economic benefits of standardization also apply in the informatics domain. Standardized access to rich data resources will create collaborative opportunities in science and business. Development and use of shared protocols and interchange formats for data publication will create a market for user applications, facilitating geoscience data discovery and utility for the benefit of society. The USGIN Working Group envisions further development of tools and capabilities, in addition to extending the community of practice that currently involves geoinformatics practitioners from the USGS and AASG. Promoting engagement and participation of the state geological surveys, and increasing communication between the states, USGS, and other

  20. Roadmap on optical rogue waves and extreme events

    Science.gov (United States)

    Akhmediev, Nail; Kibler, Bertrand; Baronio, Fabio; Belić, Milivoj; Zhong, Wei-Ping; Zhang, Yiqi; Chang, Wonkeun; Soto-Crespo, Jose M.; Vouzas, Peter; Grelu, Philippe; Lecaplain, Caroline; Hammani, K.; Rica, S.; Picozzi, A.; Tlidi, Mustapha; Panajotov, Krassimir; Mussot, Arnaud; Bendahmane, Abdelkrim; Szriftgiser, Pascal; Genty, Goery; Dudley, John; Kudlinski, Alexandre; Demircan, Ayhan; Morgner, Uwe; Amiraranashvili, Shalva; Bree, Carsten; Steinmeyer, Günter; Masoller, C.; Broderick, Neil G. R.; Runge, Antoine F. J.; Erkintalo, Miro; Residori, S.; Bortolozzo, U.; Arecchi, F. T.; Wabnitz, Stefan; Tiofack, C. G.; Coulibaly, S.; Taki, M.

    2016-06-01

    this point of view, a number of the scientists who work in this area of research have come together to present their research in a single review article that will greatly benefit all interested parties of this research direction. Whether the authors of this ‘roadmap’ have similar views or different from the original concept, the potential reader of the review will enrich their knowledge by encountering most of the existing views on the subject. Previously, a special issue on optical rogue waves (2013 J. Opt. 15 060201) was successful in achieving this goal but over two years have passed and more material has been published in this quickly emerging subject. Thus, it is time for a roadmap that may stimulate and encourage further research.

  1. Microbial Populations in Naked Neck Chicken Ceca Raised on Pasture Flock Fed with Commercial Yeast Cell Wall Prebiotics via an Illumina MiSeq Platform.

    Directory of Open Access Journals (Sweden)

    Si Hong Park

    Full Text Available Prebiotics are non-digestible carbohydrate dietary supplements that selectively stimulate the growth of one or more beneficial bacteria in the gastrointestinal tract of the host. These bacteria can inhibit colonization of pathogenic bacteria by producing antimicrobial substances such as short chain fatty acids (SCFAs and competing for niches with pathogens within the gut. Pasture flock chickens are generally raised outdoors with fresh grass, sunlight and air, which represents different environmental growth conditions compared to conventionally raised chickens. The purpose of this study was to evaluate the difference in microbial populations from naked neck chicken ceca fed with commercial prebiotics derived from brewer's yeast cell wall via an Illumina MiSeq platform. A total of 147 day-of-hatch naked neck chickens were distributed into 3 groups consisted of 1 C: control (no prebiotic, 2 T1: Biolex® MB40 with 0.2%, and 3 T2: Leiber® ExCel with 0.2%, consistently supplemented prebiotics during the experimental period. At 8 weeks, a total of 15 birds from each group were randomly selected and ceca removed for DNA extraction. The Illumina Miseq platform based on V4 region of 16S rRNA gene was applied for microbiome analysis. Both treatments exhibited limited impact on the microbial populations at the phylum level, with no significant differences in the OTU number of Bacteroidetes among groups and an increase of Proteobacteria OTUs for the T1 (Biolex® MB40 group. In addition there was a significant increase of genus Faecalibacterium OTU, phylum Firmicutes. According to the development of next generation sequencing (NGS, microbiome analysis based on 16S rRNA gene proved to be informative on the prebiotic impact on poultry gut microbiota in pasture-raised naked neck birds.

  2. Burden and treatment patterns of advanced basal cell carcinoma among commercially insured patients in a United States database from 2010 to 2014.

    Science.gov (United States)

    Migden, Michael; Xie, Jipan; Wei, Jin; Tang, Wenxi; Herrera, Vivian; Palmer, Jacqueline B

    2017-07-01

    The burden of advanced basal cell carcinoma (aBCC) is not fully understood. To compare BCC disease burden and treatment patterns for aBCC with those for non-aBCC. A retrospective, insurance claims-based study design was used. Adults with ≥2 claims associated with a BCC diagnosis (ICD-9-CM 173.x1) separated by ≥30 days on or after October 1, 2011, were classified as aBCC or non-aBCC by using an algorithm based on metastasis diagnosis, radiation therapy use, and medical oncologist/other specialist use. Non-aBCC and aBCC patients were matched 1:1 on the basis of age, sex, and region, and assigned the same index date (date of first qualifying diagnosis or event). Comparisons were made using Wilcoxon signed-rank (continuous variables) and McNemar's (categorical variables) tests. In total, 847 matched aBCC/non-aBCC patient pairs were selected (mean age 75 years; 57% men; locally advanced BCC, n = 826; metastatic BCC, n = 21). During the 12-month study period following the index date, aBCC patients had a significantly higher mean Charlson Comorbidity Index (P = .0023), significantly higher mean numbers of outpatient/dermatologist/medical oncologist visits (all P < .0001), and significantly higher mean total/medical/inpatient/outpatient/BCC treatment costs (all P < .05). This study only included information from a database on commercial insurance and Medicare claims. The algorithm criteria might have restricted patient numbers; data were not fully reflective of targeted therapy era. aBCC patients had a higher disease burden than non-aBCC patients. Cost differences were largely driven by higher BCC treatment costs, specifically radiation therapy. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  3. A Contribution to Guide the Use of Support Tools for Technology Roadmapping: a Case Study in the Clothing Industry

    OpenAIRE

    Cindy Johanna Ibarra González; André Ogliari; Aline França de Abreu

    2013-01-01

    This article presents guidelines regarding the use of tools to support technology roadmapping based on a case study of an exploratory and descriptive nature in a small company in the clothing sector. After introducing a systematic approach to technology roadmapping with their support tools, an empirical analysis is then presented of the application of the tools of the market layer – a questionnaire for consultation with the consumers and bibliographical research – and the business layer – SWO...

  4. Energia solar fotovoltaica: Contributo para um roadmapping do seu desenvolvimento tecnológico [Fotovoltaic solar energy: a contribute to a technological development roadmapping

    OpenAIRE

    Hugo Gil Silva; Marcos Afonso

    2009-01-01

    The main goal for this report is to alert for the need of a continuous investment in policies that should be developed worldwide, with respect to research and development (R&D), at all levels, in photovoltaic energy. The R&D in this area leads to a strong and possible solution to the actual environmental problems. Such problems are based on the climate change due to polluted gas emissions and due to the non-renewable resources exhaustion. Therefore, this contribution for a roadmap of photovol...

  5. Commercial Buildings Characteristics, 1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-29

    Commercial Buildings Characteristics 1992 presents statistics about the number, type, and size of commercial buildings in the United States as well as their energy-related characteristics. These data are collected in the Commercial Buildings Energy Consumption Survey (CBECS), a national survey of buildings in the commercial sector. The 1992 CBECS is the fifth in a series conducted since 1979 by the Energy Information Administration. Approximately 6,600 commercial buildings were surveyed, representing the characteristics and energy consumption of 4.8 million commercial buildings and 67.9 billion square feet of commercial floorspace nationwide. Overall, the amount of commercial floorspace in the United States increased an average of 2.4 percent annually between 1989 and 1992, while the number of commercial buildings increased an average of 2.0 percent annually.

  6. A roadmap for the EU White Paper goal on Urben Transport

    DEFF Research Database (Denmark)

    Gudmundsson, Henrik; Schippl, Jens; Leiren, Merethe Dotterud

    2015-01-01

    in urban transport by 2030; and to phase them out by 2050; and to achieve “essentially CO2-free city logistics in major urban centres by 2030.” The question driving the research behind this paper is how to realise this dual urban transport goal for 2030, taking into consideration existing trends, available...... result is a roadmap that proposes a broad strategy to answer the question “Who has to do what, by when” to achieve the urban transport goal. The roadmap includes detailed proposals for action and milestones at different levels of decision making. This paper will describe the process of consultations......In its 2011 Transport Policy White Paper, the European Commission introduced ten targets to be met in order to reach a more competitive and resource efficient transport system. The following dual goal focused on urban transport and commuting: “To halve the use of ‘conventionally-fuelled’ cars...

  7. Proceedings of the NEA International Workshop on the Nuclear Innovation road-map (NI2050)

    International Nuclear Information System (INIS)

    Ha, Jaejoo HA; Deffrennes, Marc; ); Tromm, Walter; Ait Abderrahim, Hamid; Fernandez Fernandez, Alberto; Speranzini, Robert; Jeong, Ik; Lee, Gye Seok; Castelao Lopez, Carlos; Pasamehmetoglu, Kemal; Puska, Eija Karita; Cordier, Pierre-Yves; Horvath, Akos; Agostini, Pietro; Kamide, Hideki; Nakatsuka, Toru; Roelofs, Ferry; Wrochna, Grzegorz; Zezula, Lubor; Rayment, Fiona; Cizelj, Leon; Zimmermann, Martin A.; Schmitz, Bruno; Martin-Ramos, Manuel; Andreeva-Andrievskaya, Lyudmila N.; Monti, Stefano; ); Paillere, Henri; ); Caron-Charles, Marylise; Gulliford, Jim; ); Breest, Axel; ); McGrath, Margaret; Bignan, Gilles

    2015-07-01

    The two-day workshop held at the OECD Headquarters in Paris on 7-8 July 2015, brought together some of the leading experts in the field of nuclear fission research, development and demonstration. The purpose was to launch the NEA Nuclear Innovation 2050 Initiative, aiming, after a first survey phase, at producing a road-map of main priority research programmes and infrastructures necessary to support the role nuclear energy may play in the low carbon power sector of the future. This might then further lead to some ad-hoc cooperation frameworks that help to effectively implement key priorities coming out of the road-mapping. The workshop was organised into the following five sessions: 1 - Opening session on NI2050: vision and main objectives; 2 - National presentations on nuclear fission research and innovation activities (programmes, infrastructures, budgets); 3 - Presentations on some existing international nuclear fission road-maps and co-operation frameworks; 4 - Defining the way forward for NI2050: survey, road-mapping and priorities and co-operation; 5 - Open discussion. These proceedings bring together the available presentations (slides) given during the workshop: 1. Opening session on NI2050: vision and main objectives: Setting the scene: NEA/IEA Nuclear Energy road-map 2050 (Jaejoo Ha); Proposed scope and organisation of the NI2050 project launching, taking stock of the IEA Energy RD and D survey and going further (Marc Deffrennes); 2. National presentations on nuclear fission research and innovation activities (programmes, infrastructures, budgets): Overview of German Situation with focus on HGF NUSAFE - HELMHOLTZ (W. Tromm); Investing in Nuclear Innovation in Belgium - SCKCEN (Hamid Ait Abderrahim and Alberto Fernandez); Canadian Nuclear Laboratories: Nuclear S and T and Innovation (R. Speranzini); ROK's Nuclear Policies and R and D Programs - KAERI (Ik Jeong and Lee Gye Seok); R and D Spanish Nuclear Platform (C. Castelao); NOE-NE Programs and

  8. Development Roadmap of an Evolvable and Extensible Multi-Mission Telecom Planning and Analysis Framework

    Science.gov (United States)

    Cheung, Kar-Ming; Tung, Ramona H.; Lee, Charles H.

    2003-01-01

    In this paper, we describe the development roadmap and discuss the various challenges of an evolvable and extensible multi-mission telecom planning and analysis framework. Our long-term goal is to develop a set of powerful flexible telecommunications analysis tools that can be easily adapted to different missions while maintain the common Deep Space Communication requirements. The ability of re-using the DSN ground models and the common software utilities in our adaptations has contributed significantly to our development efforts measured in terms of consistency, accuracy, and minimal effort redundancy, which can translate into shorter development time and major cost savings for the individual missions. In our roadmap, we will address the design principles, technical achievements and the associated challenges for following telecom analysis tools (i) Telecom Forecaster Predictor - TFP (ii) Unified Telecom Predictor - UTP (iii) Generalized Telecom Predictor - GTP (iv) Generic TFP (v) Web-based TFP (vi) Application Program Interface - API (vii) Mars Relay Network Planning Tool - MRNPT.

  9. Roadmapping and Strategy in Science, Technology and Innovation: Why connectivity matters

    DEFF Research Database (Denmark)

    Ricard, Lykke Margot

    The thesis focuses on the coordination of technology-intensive innovation activities at both sector and firm levels, supported by the use of the strategic roadmapping method. Investigations combine qualitative and quantitative research methods; using a narrative approach in the form of interviews...... to uncover innovation and technology barriers, and a social network analysis of stakeholders’ role in relation to two technology platforms: TPWind and ZEP (Zero Emission Platform), during a five-year period when the roadmaps 2020 were developed. In this respect, the thesis emphasizes the view of innovation...... as an interactive process to develop competences among technology users, producers, research institutions, and politicians. As a result, knowledge on how the platforms evolved, and their dynamics, provide new reflections on the innovation systems approach: that connectivity seems to change along the changes...

  10. The technology roadmap for plant/crop-based renewable resources 2020

    Energy Technology Data Exchange (ETDEWEB)

    McLaren, J.

    1999-02-22

    The long-term well-being of the nation and maintenance of a sustainable leadership position in agriculture, forestry, and manufacturing, clearly depend on current and near-term support of multidisciplinary research for the development of a reliable renewable resource base. This document sets a roadmap and priorities for that research. America needs leadership that will continue to recognize, support, and move rapidly to meet the need to expand the use of sustainable renewable resources. This roadmap has highlighted potential ways for progress and has identified goals in specific components of the system. Achieving success with these goals will provide the opportunity to hit the vision target of a fivefold increase in renewable resource use by 2020.

  11. The Technology Roadmap for Plant/Crop-Based Renewable Resources 2020

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-02-01

    The long-term well-being of the nation and maintenance of a sustainable leadership position in agriculture, forestry, and manufacturing, clearly depend on current and near-term support of multidisciplinary research for the development of a reliable renewable resource base. This document sets a roadmap and priorities for that research. America needs leadership that will continue to recognize, support, and move rapidly to meet the need to expand the use of sustainable renewable resources. This roadmap has highlighted potential ways for progress and has identified goals in specific components of the system. Achieving success with these goals will provide the opportunity to hit the vision target of a fivefold increase in renewable resource use by 2020.

  12. Combating antibiotic resistance - A Policy Roadmap to Reduce Use of Medically Important Antibiotics in Livestock

    DEFF Research Database (Denmark)

    Price, Lance B.; Newland, Jason; Bole, Aparna

    edical and public health organizations around the world agree that more prudent use of antibiotics in human medicine and in livestock production is paramount to slow the spread of antibiotic resistance. Of particular concern is the widespread use of antibiotics important to human medicine in food...... animals. In the U.S., such use accounts for 70% of all sales of medically important antibiotics. It is against this backdrop that 12 antibiotic resistance experts from the fields of infectious disease medicine, veterinary medicine, microbiology, epidemiology and public health joined to craft a policy...... roadmap to help move the U.S. forward in addressing the contribution of livestock antibiotic use to the growing global threat of antibiotic resistance. The policy roadmap consists of 11 core policy recommendations that are aimed at a broad set of stakeholders: federal, state and local policymakers, food...

  13. Advanced Safeguards Technology Road-map for the Global Nuclear Energy Partnership

    International Nuclear Information System (INIS)

    Miller, M.C.; Tobin, S.; Smith, L.E.; Ehinger, M.; Dougan, A.; Cipiti, B.; Bakel, A.; Bean, R.

    2008-01-01

    Strengthening the nonproliferation regime, including advanced safeguards, is a cornerstone of the Global Nuclear Energy Partnership (GNEP). To meet these challenges, the Safeguards Campaign was formed, whose mission is to provide research and technology development for the foundation of next generation safeguards systems for implementation in U.S. GNEP facilities. The Safeguards Campaign works closely with the Nuclear Nonproliferation and International Security department (NA-24) of NNSA (National Nuclear Safety Administration) to ensure that technology developed for domestic safeguards applications are optimum with respect to international safeguards use. A major milestone of the program this year has been the development of the advanced safeguards technology road-map. This paper will broadly describe the road-map, which provides a path to next generation safeguards systems including advanced instrumentation; process monitoring; data integration, protection, and analysis; and system level evaluation and knowledge extraction for real time applications. (authors)

  14. World Health Organization Public Health Model: A Roadmap for Palliative Care Development.

    Science.gov (United States)

    Callaway, Mary V; Connor, Stephen R; Foley, Kathleen M

    2018-02-01

    The Open Society Foundation's International Palliative Care Initiative (IPCI) began to support palliative care development in Central and Eastern Europe and the Former Soviet Union in 1999. Twenty-five country representatives were invited to discuss the need for palliative care in their countries and to identify key areas that should be addressed to improve the care of adults and children with life-limiting illnesses. As a public health concern, progress in palliative care requires integration into health policy, education and training of health care professionals, availability of essential pain relieving medications, and health care services. IPCI created the Palliative Care Roadmap to serve as a model for government and/or nongovernment organizations to use to frame the necessary elements and steps for palliative care integration. The roadmap includes the creation of multiple Ministry of Health-approved working groups to address: palliative care inclusion in national health policy, legislation, and finance; availability of essential palliative care medications, especially oral opioids; education and training of health care professionals; and the implementation of palliative care services at home or in inpatient settings for adults and children. Each working group is tasked with developing a pathway with multiple signposts as indicators of progress made. The roadmap may be entered at different signposts depending upon the state of palliative care development in the country. The progress of the working groups often takes place simultaneously but at variable rates. Based on our experience, the IPCI Roadmap is one possible framework for palliative care development in resource constrained countries but requires both health care professional engagement and political will for progress to be made. Copyright © 2017. Published by Elsevier Inc.

  15. Toward Simulating Realistic Pursuit-Evasion Using a Roadmap-Based Approach

    KAUST Repository

    Rodriguez, Samuel

    2010-01-01

    In this work, we describe an approach for modeling and simulating group behaviors for pursuit-evasion that uses a graph-based representation of the environment and integrates multi-agent simulation with roadmap-based path planning. We demonstrate the utility of this approach for a variety of scenarios including pursuit-evasion on terrains, in multi-level buildings, and in crowds. © 2010 Springer-Verlag Berlin Heidelberg.

  16. Technology Assessment and Roadmap for the Emergency Radiation Dose Assessment Program

    Energy Technology Data Exchange (ETDEWEB)

    Turteltaub, K W; Hartman-Siantar, C; Easterly, C; Blakely, W

    2005-10-03

    A Joint Interagency Working Group (JIWG) under the auspices of the Department of Homeland Security Office of Research and Development conducted a technology assessment of emergency radiological dose assessment capabilities as part of the overall need for rapid emergency medical response in the event of a radiological terrorist event in the United States. The goal of the evaluation is to identify gaps and recommend general research and development needs to better prepare the Country for mitigating the effects of such an event. Given the capabilities and roles for responding to a radiological event extend across many agencies, a consensus of gaps and suggested development plans was a major goal of this evaluation and road-mapping effort. The working group consisted of experts representing the Departments of Homeland Security, Health and Human Services (Centers for Disease Control and the National Institutes of Health), Food and Drug Administration, Department of Defense and the Department of Energy's National Laboratories (see appendix A for participants). The specific goals of this Technology Assessment and Roadmap were to: (1) Describe the general context for deployment of emergency radiation dose assessment tools following terrorist use of a radiological or nuclear device; (2) Assess current and emerging dose assessment technologies; and (3) Put forward a consensus high-level technology roadmap for interagency research and development in this area. This report provides a summary of the consensus of needs, gaps and recommendations for a research program in the area of radiation dosimetry for early response, followed by a summary of the technologies available and on the near-term horizon. We then present a roadmap for a research program to bring present and emerging near-term technologies to bear on the gaps in radiation dose assessment and triage. Finally we present detailed supporting discussion on the nature of the threats we considered, the status of

  17. Linking Six Sigma to simulation: a new roadmap to improve the quality of patient care.

    Science.gov (United States)

    Celano, Giovanni; Costa, Antonio; Fichera, Sergio; Tringali, Giuseppe

    2012-01-01

    Improving the quality of patient care is a challenge that calls for a multidisciplinary approach, embedding a broad spectrum of knowledge and involving healthcare professionals from diverse backgrounds. The purpose of this paper is to present an innovative approach that implements discrete-event simulation (DES) as a decision-supporting tool in the management of Six Sigma quality improvement projects. A roadmap is designed to assist quality practitioners and health care professionals in the design and successful implementation of simulation models within the define-measure-analyse-design-verify (DMADV) or define-measure-analyse-improve-control (DMAIC) Six Sigma procedures. A case regarding the reorganisation of the flow of emergency patients affected by vertigo symptoms was developed in a large town hospital as a preliminary test of the roadmap. The positive feedback from professionals carrying out the project looks promising and encourages further roadmap testing in other clinical settings. The roadmap is a structured procedure that people involved in quality improvement can implement to manage projects based on the analysis and comparison of alternative scenarios. The role of Six Sigma philosophy in improvement of the quality of healthcare services is recognised both by researchers and by quality practitioners; discrete-event simulation models are commonly used to improve the key performance measures of patient care delivery. The two approaches are seldom referenced and implemented together; however, they could be successfully integrated to carry out quality improvement programs. This paper proposes an innovative approach to bridge the gap and enrich the Six Sigma toolbox of quality improvement procedures with DES.

  18. BUSINESS MODEL ROADMAPPING: A PRACTICAL APPROACH TO COME FROM AN EXISTING TO A DESIRED BUSINESS MODEL

    OpenAIRE

    MARK DE REUVER; HARRY BOUWMAN; TIMBER HAAKER

    2013-01-01

    Literature on business models deals extensively with how to design new business models, but hardly with how to make the transition from an existing to a newly designed business model. The transition to a new business model raises several practical and strategic issues, such as how to replace an existing value proposition with a new one, when to acquire new resources and capabilities, and when to start new partnerships. In this paper, we coin the term business model roadmapping as an approach ...

  19. Traumatic Brain Injury Diffusion Magnetic Resonance Imaging Research Roadmap Development Project

    Science.gov (United States)

    2012-10-01

    optical imaging methods, PET/SPECT with radioisotope agents, and other technologies are less generally available or have known limitations. No “one...Brain Injury D-MRI Research Roadmap Development Project. Product Line Review (PLR) meeting, Medical Imaging Technologies. 12 June 2012. 11. Xia...meeting, Medical Imaging Technologies. Presentation slides. 12 June 2012. 1 Product Line Traumatic Brain Injury Diffusion Magnetic Resonance

  20. A covenant of halflings? developing a roadmap for the european urban transport goal

    DEFF Research Database (Denmark)

    Gudmundsson, Henrik; Schippl, Jens; Anderton, Karen

    2015-01-01

    ; and to phase them out by 2050; and “To achieve ‘essentially CO2- free city logistics’ in major urban centres by 2030.” This paper describes how the EU FP7 project TRANSFORUM conducted a stakeholder-driven process to produce a roadmap for the urban transport goal. A main conclusion was that the implementation......In the 2011 Transport Policy White Paper, the European Commission introduced ten goals for a more competitive and resource efficient transport system. One of the goal concerns urban transport, with the dual targets: “To halve the use of ‘conventionally-fuelled’ cars in urban transport by 2030...... of a roadmap for urban transport needs to adopt a broad and open approach, given the diversity among member states and cities across Europe. Also it was found that replacing conventional vehicles and fuels is an important but not sufficient strategy to reach the goal. A roadmap to reach towards the ‘halving...