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Sample records for cell biologist don

  1. Human radiation studies: Remembering the early years: Oral history of cell biologist Don Francis Petersen, Ph.D., conducted November 29, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    This report is a transcript of an interview of Dr. Don Francis Petersen by representatives of the US DOE Office of Human Radiation Experiments. Dr. Petersen was selected for this interview because of his long research career at Los Alamos and his knowledge of the Atomic Energy Commission`s biomedical program. Dr. Petersen did not personally conduct research on human subjects. After a brief biographical sketch Dr. Petersen discusses his remembrances of the early use of radionuclides as biological tracers, aspects of nuclear weapons testing in the 1940`s and 1950`s including fallout studies, the means by which research projects were approved, use of humans in the whole-body counter, and the Health Division Biomedical responsibilities.

  2. Human radiation studies: Remembering the early years: Oral history of cell biologist Don Francis Petersen, Ph.D., conducted November 29, 1994

    International Nuclear Information System (INIS)

    1995-08-01

    This report is a transcript of an interview of Dr. Don Francis Petersen by representatives of the US DOE Office of Human Radiation Experiments. Dr. Petersen was selected for this interview because of his long research career at Los Alamos and his knowledge of the Atomic Energy Commission's biomedical program. Dr. Petersen did not personally conduct research on human subjects. After a brief biographical sketch Dr. Petersen discusses his remembrances of the early use of radionuclides as biological tracers, aspects of nuclear weapons testing in the 1940's and 1950's including fallout studies, the means by which research projects were approved, use of humans in the whole-body counter, and the Health Division Biomedical responsibilities

  3. GeneSpeed Beta Cell: An Online Genomics Data Repository and Analysis Resource Tailored for the Islet Cell Biologist

    Directory of Open Access Journals (Sweden)

    Nayeem Quayum

    2008-01-01

    Full Text Available Objective. We here describe the development of a freely available online database resource, GeneSpeed Beta Cell, which has been created for the pancreatic islet and pancreatic developmental biology investigator community. Research Design and Methods. We have developed GeneSpeed Beta Cell as a separate component of the GeneSpeed database, providing a genomics-type data repository of pancreas and islet-relevant datasets interlinked with the domain-oriented GeneSpeed database. Results. GeneSpeed Beta Cell allows the query of multiple published and unpublished select genomics datasets in a simultaneous fashion (multiexperiment viewing and is capable of defining intersection results from precomputed analysis of such datasets (multidimensional querying. Combined with the protein-domain categorization/assembly toolbox provided by the GeneSpeed database, the user is able to define spatial expression constraints of select gene lists in a relatively rigid fashion within the pancreatic expression space. We provide several demonstration case studies of relevance to islet cell biology and development of the pancreas that provide novel insight into islet biology. Conclusions. The combination of an exhaustive domain-based compilation of the transcriptome with gene array data of interest to the islet biologist affords novel methods for multidimensional querying between individual datasets in a rapid fashion, presently not available elsewhere.

  4. Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope

    Science.gov (United States)

    Hosny, Neveen A.; Song, Mingying; Connelly, John T.; Ameer-Beg, Simon; Knight, Martin M.; Wheeler, Ann P.

    2013-01-01

    In this study we use a spinning disk confocal microscope (SD) to generate super-resolution images of multiple cellular features from any plane in the cell. We obtain super-resolution images by using stochastic intensity fluctuations of biological probes, combining Photoactivation Light-Microscopy (PALM)/Stochastic Optical Reconstruction Microscopy (STORM) methodologies. We compared different image analysis algorithms for processing super-resolution data to identify the most suitable for analysis of particular cell structures. SOFI was chosen for X and Y and was able to achieve a resolution of ca. 80 nm; however higher resolution was possible >30 nm, dependant on the super-resolution image analysis algorithm used. Our method uses low laser power and fluorescent probes which are available either commercially or through the scientific community, and therefore it is gentle enough for biological imaging. Through comparative studies with structured illumination microscopy (SIM) and widefield epifluorescence imaging we identified that our methodology was advantageous for imaging cellular structures which are not immediately at the cell-substrate interface, which include the nuclear architecture and mitochondria. We have shown that it was possible to obtain two coloured images, which highlights the potential this technique has for high-content screening, imaging of multiple epitopes and live cell imaging. PMID:24130668

  5. Charged Particles are Prevented from Going Faster than the Speed of Light by Light Itself: A Biophysical Cell Biologist's Contribution to Physics

    International Nuclear Information System (INIS)

    Wayne, R.

    2010-01-01

    Investigations of living organisms have led biologists and physicians to introduce fundamental concepts, including Brownian motion, the First Law of Thermodynamics, Poiseuille's Law of fluid flow, and Fick's Law of diffusion into physics. Given the prominence of viscous forces within and around cells and the experience of identifying and quantifying such resistive forces, biophysical cell biologists have an unique perspective in discovering the viscous forces that cause moving particles to respond to an applied force in a nonlinear manner. Using my experience as a biophysical cell biologist, I show that in any space consisting of a photon gas with a temperature above absolute zero, Doppler-shifted photons exert a velocity-dependent viscous force on moving charged particles. This viscous force prevents charged particles from exceeding the speed of light. Consequently, light itself prevents charged particles from moving faster than the speed of light. This interpretation provides a testable alternative to the interpretation provided by the Special Theory of Relativity, which contends that particles are prevented from exceeding the speed of light as a result of the relativity of time. (author)

  6. Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights

    Energy Technology Data Exchange (ETDEWEB)

    Katika, Madhumohan R. [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands); Department of Health Risk Analysis and Toxicology, Maastricht University (Netherlands); Netherlands Toxicogenomics Centre (Netherlands); Hendriksen, Peter J.M. [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands); Netherlands Toxicogenomics Centre (Netherlands); Shao, Jia [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands); Department of Health Risk Analysis and Toxicology, Maastricht University (Netherlands); Netherlands Toxicogenomics Centre (Netherlands); Loveren, Henk van [Department of Health Risk Analysis and Toxicology, Maastricht University (Netherlands); National Institute for Public Health and the Environment (RIVM), Bilthoven (Netherlands); Netherlands Toxicogenomics Centre (Netherlands); Peijnenburg, Ad, E-mail: ad.peijnenburg@wur.nl [RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen (Netherlands); Netherlands Toxicogenomics Centre (Netherlands)

    2012-10-01

    Deoxynivalenol (DON) or vomitoxin is a commonly encountered type-B trichothecene mycotoxin, produced by Fusarium species predominantly found in cereals and grains. DON is known to exert toxic effects on the gastrointestinal, reproductive and neuroendocrine systems, and particularly on the immune system. Depending on dose and exposure time, it can either stimulate or suppress immune function. The main objective of this study was to obtain a deeper insight into DON-induced effects on lymphoid cells. For this, we exposed the human T-lymphocyte cell line Jurkat and human peripheral blood mononuclear cells (PBMCs) to various concentrations of DON for various times and examined gene expression changes by DNA microarray analysis. Jurkat cells were exposed to 0.25 and 0.5 μM DON for 3, 6 and 24 h. Biological interpretation of the microarray data indicated that DON affects various processes in these cells: It upregulates genes involved in ribosome structure and function, RNA/protein synthesis and processing, endoplasmic reticulum (ER) stress, calcium-mediated signaling, mitochondrial function, oxidative stress, the NFAT and NF-κB/TNF-α pathways, T cell activation and apoptosis. The effects of DON on the expression of genes involved in ER stress, NFAT activation and apoptosis were confirmed by qRT-PCR. Other biochemical experiments confirmed that DON activates calcium-dependent proteins such as calcineurin and M-calpain that are known to be involved in T cell activation and apoptosis. Induction of T cell activation was also confirmed by demonstrating that DON activates NFATC1 and induces its translocation from the cytoplasm to the nucleus. For the gene expression profiling of PBMCs, cells were exposed to 2 and 4 μM DON for 6 and 24 h. Comparison of the Jurkat microarray data with those obtained with PBMCs showed that most of the processes affected by DON in the Jurkat cell line were also affected in the PBMCs. -- Highlights: ► The human T cell line Jurkat and human

  7. Deoxynivalenol (DON) is toxic to human colonic, lung and monocytic cell lines, but does not increase the IgE response in a mouse model for allergy

    International Nuclear Information System (INIS)

    Instanes, Christine; Hetland, Geir

    2004-01-01

    We examined whether the common crop mycotoxin deoxynivalenol (DON) from Fusarium species is toxic to human colonic (Caco-2), lung (A549) and monocytic (U937) cell lines. Moreover, since DON reportedly induces increased levels of Th2 cytokines and total IgE, and we have observed that mould extracts adjuvated allergy development in mice, possible adjuvant effect of DON on allergy was studied in a mouse model. For all the cells, exposure to DON for 24 h reduced cellular protein synthesis, proliferation and survival rate dose-dependently. In addition, production of IL-8 in the U937 cell line increased up to eight-fold at levels of DON just lower than the most toxic one, suggesting that IL-8 can be used as an additional index for cytotoxicity in mononuclear phagocytes. However, DON did not increase levels of allergen-specific IgE or IgG1 in the mouse model for allergy. These results suggest that DON, when inhaled or ingested, may have toxic effect on human alveolar macrophages and epithelial cells in lungs and colon, but does not increase the allergic response to allergens

  8. Tihhi Don

    Index Scriptorium Estoniae

    2006-01-01

    Fjodor Bondartshuk monteeris kokku tema isa Sergei poolt Itaalias 13 aastat tagasi pooleli jäänud Mihhail Sholohhovi romaani järgi tehtud teleseriaali "Vaikne Don", mida Venemaa televisiooni 1. Kanal näitab alates 7. novembrist

  9. Microbial biotransformation of DON: molecular basis for reduced toxicity

    Science.gov (United States)

    Pierron, Alix; Mimoun, Sabria; Murate, Leticia S.; Loiseau, Nicolas; Lippi, Yannick; Bracarense, Ana-Paula F. L.; Schatzmayr, Gerd; He, Jian Wei; Zhou, Ting; Moll, Wulf-Dieter; Oswald, Isabelle P.

    2016-07-01

    Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, to deepoxy-deoxynivalenol (deepoxy-DON or DOM-1) or 3-epi-deoxynivalenol (3-epi-DON), respectively. Using different approaches, the intestinal toxicity of 3 molecules was compared and the molecular basis for the reduced toxicity investigated. In human intestinal epithelial cells, deepoxy-DON and 3-epi-DON were not cytotoxic, did not change the oxygen consumption or impair the barrier function. In intestinal explants, exposure for 4 hours to 10 μM DON induced intestinal lesions not seen in explants treated with deepoxy-DON and 3-epi-DON. A pan-genomic transcriptomic analysis was performed on intestinal explants. 747 probes, representing 323 genes, were differentially expressed, between DON-treated and control explants. By contrast, no differentially expressed genes were observed between control, deepoxy-DON and 3-epi-DON treated explants. Both DON and its biotransformation products were able to fit into the pockets of the A-site of the ribosome peptidyl transferase center. DON forms three hydrogen bonds with the A site and activates MAPKinases (mitogen-activated protein kinases). By contrast deepoxy-DON and 3-epi-DON only form two hydrogen bonds and do not activate MAPKinases. Our data demonstrate that bacterial de-epoxidation or epimerization of DON altered their interaction with the ribosome, leading to an absence of MAPKinase activation and a reduced toxicity.

  10. Biotransformation of artemisinin using cell suspension cultures of Catharanthus roseus (L.) G.Don and Lavandula officinalis L.

    Science.gov (United States)

    Patel, Suman; Gaur, Rashmi; Verma, Priyanka; Bhakuni, Rajendra S; Mathur, Archana

    2010-08-01

    Artemisinin, an antimalarial compound, at 5 mg/40 ml, was transformed by cell suspension cultures of Catharanthus roseus (L.) G.Don and Lavandula officinalis L. into deoxyartemisinin with yields >78% (3.93 mg deoxyartemisinin from 5 mg artemisinin). Maximum conversion (78.6 and 78%) occurred after 6 and 7 days of adding artemisinin to 20 and 9 days old cultures of C. roseus and L. officinalis, respectively. The procedure was scaled up by and 500 mg artemisinin was transformed into 390 mg deoxyartemisinin. Addition of artemisinin at the beginning of the culture cycle resulted in >50% reduction in dry biomass production with no bioconversion. Conversion of artemisinin occurred intracellularly followed by leaching of the product into the medium.

  11. Which statistics should tropical biologists learn?

    Science.gov (United States)

    Loaiza Velásquez, Natalia; González Lutz, María Isabel; Monge-Nájera, Julián

    2011-09-01

    Tropical biologists study the richest and most endangered biodiversity in the planet, and in these times of climate change and mega-extinctions, the need for efficient, good quality research is more pressing than in the past. However, the statistical component in research published by tropical authors sometimes suffers from poor quality in data collection; mediocre or bad experimental design and a rigid and outdated view of data analysis. To suggest improvements in their statistical education, we listed all the statistical tests and other quantitative analyses used in two leading tropical journals, the Revista de Biología Tropical and Biotropica, during a year. The 12 most frequent tests in the articles were: Analysis of Variance (ANOVA), Chi-Square Test, Student's T Test, Linear Regression, Pearson's Correlation Coefficient, Mann-Whitney U Test, Kruskal-Wallis Test, Shannon's Diversity Index, Tukey's Test, Cluster Analysis, Spearman's Rank Correlation Test and Principal Component Analysis. We conclude that statistical education for tropical biologists must abandon the old syllabus based on the mathematical side of statistics and concentrate on the correct selection of these and other procedures and tests, on their biological interpretation and on the use of reliable and friendly freeware. We think that their time will be better spent understanding and protecting tropical ecosystems than trying to learn the mathematical foundations of statistics: in most cases, a well designed one-semester course should be enough for their basic requirements.

  12. A chemist and biologist talk to each other about caged neurotransmitters

    Directory of Open Access Journals (Sweden)

    Graham C.R. Ellis-Davies

    2013-01-01

    Full Text Available Caged compounds are small organic molecules that can be photoactivated with brief pulses of light. They are widely used to study a great variety of biological processes by physiologists, cell biologists and neuroscientists. Initially made and invented by biologists in the late 1970s, they are now made mostly by chemists, often without any dialogue with the end users, the biologists. The idea for this review is to stimulate interaction between the two communities to further the creative development and application of these powerful optical probes.

  13. Which statistics should tropical biologists learn?

    Directory of Open Access Journals (Sweden)

    Natalia Loaiza Velásquez

    2011-09-01

    Full Text Available Tropical biologists study the richest and most endangered biodiversity in the planet, and in these times of climate change and mega-extinctions, the need for efficient, good quality research is more pressing than in the past. However, the statistical component in research published by tropical authors sometimes suffers from poor quality in data collection; mediocre or bad experimental design and a rigid and outdated view of data analysis. To suggest improvements in their statistical education, we listed all the statistical tests and other quantitative analyses used in two leading tropical journals, the Revista de Biología Tropical and Biotropica, during a year. The 12 most frequent tests in the articles were: Analysis of Variance (ANOVA, Chi-Square Test, Student’s T Test, Linear Regression, Pearson’s Correlation Coefficient, Mann-Whitney U Test, Kruskal-Wallis Test, Shannon’s Diversity Index, Tukey’s Test, Cluster Analysis, Spearman’s Rank Correlation Test and Principal Component Analysis. We conclude that statistical education for tropical biologists must abandon the old syllabus based on the mathematical side of statistics and concentrate on the correct selection of these and other procedures and tests, on their biological interpretation and on the use of reliable and friendly freeware. We think that their time will be better spent understanding and protecting tropical ecosystems than trying to learn the mathematical foundations of statistics: in most cases, a well designed one-semester course should be enough for their basic requirements. Rev. Biol. Trop. 59 (3: 983-992. Epub 2011 September 01.Los biólogos tropicales estudian la biodiversidad más rica y amenazada del planeta, y en estos tiempos de cambio climático y mega-extinción, la necesidad de investigación de buena calidad es más acuciante que en el pasado. Sin embargo, el componente estadístico en la investigación publicada por los autores tropicales adolece a veces

  14. State-transition diagrams for biologists.

    Directory of Open Access Journals (Sweden)

    Hugues Bersini

    Full Text Available It is clearly in the tradition of biologists to conceptualize the dynamical evolution of biological systems in terms of state-transitions of biological objects. This paper is mainly concerned with (but obviously not limited too the immunological branch of biology and shows how the adoption of UML (Unified Modeling Language state-transition diagrams can ease the modeling, the understanding, the coding, the manipulation or the documentation of population-based immune software model generally defined as a set of ordinary differential equations (ODE, describing the evolution in time of populations of various biological objects. Moreover, that same UML adoption naturally entails a far from negligible representational economy since one graphical item of the diagram might have to be repeated in various places of the mathematical model. First, the main graphical elements of the UML state-transition diagram and how they can be mapped onto a corresponding ODE mathematical model are presented. Then, two already published immune models of thymocyte behavior and time evolution in the thymus, the first one originally conceived as an ODE population-based model whereas the second one as an agent-based one, are refactored and expressed in a state-transition form so as to make them much easier to understand and their respective code easier to access, to modify and run. As an illustrative proof, for any immunologist, it should be possible to understand faithfully enough what the two software models are supposed to reproduce and how they execute with no need to plunge into the Java or Fortran lines.

  15. Cell Phones in the Classroom: Don't Put Them Away Just Yet!

    Science.gov (United States)

    Webb, Carolyn Lorraine

    2013-01-01

    As the number of students with cell phones has steadily increased over the past decade, these technological advances have caused trepidation among educators over behavioral issues, from off-task activities to cheating (Prensky, 2005). On the other hand, mobile learning, as well as some tools to use with cell phones, are easy to set up, easy to…

  16. Stem cell therapy for white matter disorders: don't forget the microenvironment!

    NARCIS (Netherlands)

    Dooves, Stephanie; van der Knaap, Marjo S.; Heine, Vivi M.

    2016-01-01

    White matter disorders (WMDs) are a major source of handicap at all ages. They often lead to progressive neurological dysfunction and early death. Although causes are highly diverse, WMDs share the property that glia (astrocytes and oligodendrocytes) are among the cells primarily affected, and that

  17. Apical–basal polarity: why plant cells don't stand on their heads

    Czech Academy of Sciences Publication Activity Database

    Friml, J.; Benfey, P.; Benková, E.; Bennett, M. D.; Berleth, T.; Geldner, N.; Grebe, M.; Heisler, M.; Hejátko, J.; Jürgens, G.; Laux, T.; Lindsey, K.; Lukowitz, W.; Luschnig, Ch.; Offringa, R.; Scheres, B.; Swarup, R.; Torres-Ruiz, R.; Weijers, D.; Zažímalová, Eva

    2006-01-01

    Roč. 11, č. 1 (2006), s. 12-14 ISSN 1360-1385 R&D Projects: GA AV ČR IAA6038303 Institutional research plan: CEZ:AV0Z50380511 Keywords : Apical * Basal * Polarity of plant cell Subject RIV: EF - Botanics Impact factor: 8.000, year: 2006

  18. Transcriptome analysis of the human T Lymphocyte cell line Jurkat and human periheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights

    NARCIS (Netherlands)

    Katika, M.R.; Hendriksen, P.J.M.; Shao, J.; Loveren, van H.; Peijnenburg, A.A.C.M.

    2012-01-01

    Deoxynivalenol (DON) or vomitoxin is a commonly encountered type-B trichothecene mycotoxin, produced by Fusarium species predominantly found in cereals and grains. DON is known to exert toxic effects on the gastrointestinal, reproductive and neuroendocrine systems, and particularly on the immune

  19. Radiation biology for the non-biologist

    International Nuclear Information System (INIS)

    Myers, D.K.

    1978-06-01

    This colloquium introduces some of the general concepts used in cell biology and in the study of the effects of ionizing radiation on living organisms. The present research activities in radiation biology in the Biology Branch at the Chalk River Nuclear Laboratories cover a broad range of interests in the entire chain of events by which the initial radiation-induced changes in the living cell are translated into significant biological effects, including the eventual production of cancers and hereditary defects. The main theme of these research activities is an understanding of the mechanisms by which radiation damage to DNA (the carrier of hereditary information in all living organisms) can be actively repaired by the living cell. Advances in our understanding of these processes have broad implications for other areas of biology but also bear directly on the assessment of the biological hazards of ionizing radiation. The colloquium concludes with a brief discussion of the hazards of low-level radiation. (author)

  20. Meet EPA Biologist Laura Jackson, Ph.D.

    Science.gov (United States)

    Research Biologist Laura Jackson, Ph.D., has worked for the EPA for 22 years, leading research initiatives in a diversity of disciplines, including environmental monitoring, land use planning, and the impacts that urbanization has on an area's ecology

  1. Meet EPA Biologist Thomas Knudsen, Ph.D.

    Science.gov (United States)

    Dr. Tom Knudsen is a developmental systems biologist at EPA's Center for Computational Toxicology. His research focuses on the potential for chemicals to disrupt prenatal development—one of the most important life stages.

  2. Life and death: a biologist's view.

    Science.gov (United States)

    Giuditta, Antonio

    2002-01-01

    The strict link between life and death of an organism should be discussed and compared to the life cycles of molecules and cells that allow the organism's development and survival. Indeed, a brief consideration of the main features of biological functions reveals that they occur at widely different levels of organization, ranging from molecules to species and ecological systems, and occupying widely different spatio-temporal domains. Biological functions are characterized by the integrated motion of their constitutive parts, and operate in cyclic fashions that comprise on and off phases. The birth and death of molecules, cells, organisms or species represent a special class of cycling functions that support the life cycles of the entities that include them. Under this perspective, the life cycles of past, present and future human beings may be viewed as necessary support to the longer lasting and more widely spreading life cycles of families, nations, and civilizations. If due consideration is given to our deep mental nature, one may cherish the conclusion that past, present and future human beings may be all supporting the life cycle of a superior mental entity that includes us in the same way we include our own cellular and molecular components.

  3. Assessing and benchmarking multiphoton microscopes for biologists.

    Science.gov (United States)

    Corbin, Kaitlin; Pinkard, Henry; Peck, Sebastian; Beemiller, Peter; Krummel, Matthew F

    2014-01-01

    Multiphoton microscopy has become staple tool for tracking cells within tissues and organs due to superior depth of penetration, low excitation volumes, and reduced phototoxicity. Many factors, ranging from laser pulse width to relay optics to detectors and electronics, contribute to the overall ability of these microscopes to excite and detect fluorescence deep within tissues. However, we have found that there are few standard ways already described in the literature to distinguish between microscopes or to benchmark existing microscopes to measure the overall quality and efficiency of these instruments. Here, we discuss some simple parameters and methods that can either be used within a multiphoton facility or by a prospective purchaser to benchmark performance. This can both assist in identifying decay in microscope performance and in choosing features of a scope that are suited to experimental needs. © 2014 Elsevier Inc. All rights reserved.

  4. Assessing and benchmarking multiphoton microscopes for biologists

    Science.gov (United States)

    Corbin, Kaitlin; Pinkard, Henry; Peck, Sebastian; Beemiller, Peter; Krummel, Matthew F.

    2017-01-01

    Multiphoton microscopy has become staple tool for tracking cells within tissues and organs due to superior depth of penetration, low excitation volumes, and reduced phototoxicity. Many factors, ranging from laser pulse width to relay optics to detectors and electronics, contribute to the overall ability of these microscopes to excite and detect fluorescence deep within tissues. However, we have found that there are few standard ways already described in the literature to distinguish between microscopes or to benchmark existing microscopes to measure the overall quality and efficiency of these instruments. Here, we discuss some simple parameters and methods that can either be used within a multiphoton facility or by a prospective purchaser to benchmark performance. This can both assist in identifying decay in microscope performance and in choosing features of a scope that are suited to experimental needs. PMID:24974026

  5. Biodiversities and habitabilities : a biologist view

    Science.gov (United States)

    Maurel, Marie-Christine

    2015-07-01

    If life were to again take the path it followed billion years ago, nobody can certify that it would take the same path, leading to the same species, the same types of cells, the same organisation. This implies that if life exists - or existed - elsewhere, benefiting from the same initial planetary conditions, it most likely does would not have the same history, or would not have followed the same itinerary. Thus, how can we possibly recognize and/or identify something new, probably completely new that we are unable to conceive and/or to conceptualize? From a materialistic point of view, there is no frontier between what is alive and what is not; this is a basic question for the biology community, mainly via the question of viruses and viroids. It is thus very ambiguous to define the meaning of biomarkers, and even more to search for life elsewhere based strictly on the observations of what we know occurs on Earth. Just as what is 'pathological' in biology provides us with an insight on what is 'normal', the space that lies at the border between the living and the non-living will maybe allow us to envisage other forms of life (that we cannot imagine to-day).

  6. What history tells us XVIII. When functional biologists propose ...

    Indian Academy of Sciences (India)

    2009-08-19

    Aug 19, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 3. What history tells us XVIII. When functional biologists propose mechanisms of evolution. Michel Morange. Series Volume 34 Issue 3 September 2009 pp 373-376. Fulltext. Click here to view fulltext PDF. Permanent link:

  7. Dr Jacob van der Land, marine biologist extraordinary

    NARCIS (Netherlands)

    Bruggen, van A.C.

    2001-01-01

    This contribution is an attempt to sketch the life and works of Dr Jacob van der Land, curator of worms and chief marine biologist of the National Museum of Natural History, on the occasion of his official retirement. Born in 1935, Jacob van der Land read biology at Leiden University (1958-1964),

  8. the contrasting attitudes of plant breeders and molecular biologists ...

    Indian Academy of Sciences (India)

    I draw attention to the perceptions of and interactions between molecular biologists and scientists engaged in plant breeding in India, who have been attempting to employ molecular biology tools to understand and intervene to improve the rice crop. The present essay suggests that the concept of cognitive empathy is ...

  9. THE DESCENT OF LANGUAGE. A CONVERSATION BETWEEN TWO JOBLESS BIOLOGISTS

    Directory of Open Access Journals (Sweden)

    D'Angelo Giovanni

    2013-12-01

    Full Text Available Seen from the perspective of a biologist, the issue of the origin of language contains an inherent ambiguity. On the one hand, one might think to explore the cognitive features or even the anatomical structures related to communication through the peculiar medium called verbal language, a characteristic property emergent among the Homo sapiens. On the other hand, if one decides to restrict oneself to the formal definition of language as a system of signs for encoding information, then, the human-specific nature of language becomes less convincing and the temptation to look into non-human languages allows a provocative question. Was human verbal language an invention or a discovery? In the following two biologists informally discuss about the concept of non-verbal biological languages.

  10. The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-O-Glucoside, 15-Acetyl-DON-3-O-Glucoside and 15-Acetyl-DON-3-Sulfate

    Directory of Open Access Journals (Sweden)

    Clemens Schmeitzl

    2015-08-01

    Full Text Available Deoxynivalenol (DON is a protein synthesis inhibitor produced by the Fusarium species, which frequently contaminates grains used for human or animal consumption. We treated a wheat suspension culture with DON or one of its acetylated derivatives, 3-acetyl-DON (3-ADON, 15-acetyl-DON (15-ADON and 3,15-diacetyl-DON (3,15-diADON, and monitored the metabolization over a course of 96 h. Supernatant and cell extract samples were analyzed using a tailored LC-MS/MS method for the quantification of DON metabolites. We report the formation of tentatively identified DON-15-O-β-D-glucoside (D15G and of 15-acetyl-DON-3-sulfate (15-ADON3S as novel deoxynivalenol metabolites in wheat. Furthermore, we found that the recently identified 15-acetyl-DON-3-O-β-D-glucoside (15-ADON3G is the major metabolite produced after 15-ADON challenge. 3-ADON treatment led to a higher intracellular content of toxic metabolites after six hours compared to all other treatments. 3-ADON was exclusively metabolized into DON before phase II reactions occurred. In contrast, we found that 15-ADON was directly converted into 15-ADON3G and 15-ADON3S in addition to metabolization into deoxynivalenol-3-O-β-D-glucoside (D3G. This study highlights significant differences in the metabolization of DON and its acetylated derivatives.

  11. The Hydra genome: insights, puzzles and opportunities for developmental biologists.

    Science.gov (United States)

    Steele, Robert E

    2012-01-01

    The sequencing of a Hydra genome marked the beginning of a new era in the use of Hydra as a developmental model. Analysis of the genome sequence has led to a number of interesting findings, has required revisiting of previous work, and most importantly presents new opportunities for understanding the developmental biology of Hydra. This review will de-scribe the history of the Hydra genome project, a selection of results from it that are relevant to developmental biologists, and some future research opportunities provided by Hydra genomics.

  12. Improving interactions between animal rights groups and conservation biologists.

    Science.gov (United States)

    Perry, Dan; Perry, Gad

    2008-02-01

    Invasive species are often considered to be a major threat to biodiversity, leading conservation biologists to often recommend their complete eradication. Animal rights groups typically categorically oppose killing animals, and their opposition has brought eradication attempts of gray squirrels in northern Italy (Europe) and mute swans in Vermont to a halt. As a result native red squirrels may disappear from Europe and ecosystem-wide impacts are expected to be caused by the swan. In contrast, cooperation between managers and animal rights groups has resulted in a successful control program for feral pigs in Fort Worth, Texas (U.S.A.). The philosophical differences between animal rights and conservation biologists' views make cooperation seem unlikely, yet documented cases of cooperation have been beneficial for both groups. We recommend that managers dealing with invasive species should consult with social scientists and ethicists to gain a better understanding of the implications of some of their policy decisions. In addition, we recommend that animal rights groups do more to support alternatives to lethal control, which are often excluded by economic limitations. Prevention of arrival of invasive species via application of the precautionary principle may be an especially productive avenue for such collaboration because it fits the goals and values of both groups.

  13. Don Eddy; "Jewelry."

    Science.gov (United States)

    Schaefer, Claire

    1989-01-01

    Presents a lesson that introduces students in grades K-three to sources of design inspiration in contemporary urban settings. Using Don Eddy's painting of a jewelry store window display, asks students to describe and analyze the interplay of shape, pattern, and color. Suggests studio activities, including an activity in which students build a…

  14. Neurology and Don Quixote.

    Science.gov (United States)

    Palma, Jose-Alberto; Palma, Fermin

    2012-01-01

    Don Quixote de la Mancha, which is considered one of the most important and influential works of Western modern prose, contains many references of interest for almost all of the medical specialties. In this regard, numerous references to neurology can be found in Cervantes' immortal work. In this study, we aimed to read Don Quixote from a neurologist's point of view, describing the neurological phenomena scattered throughout the novel, including tremors, sleep disturbances, neuropsychiatric symptoms, dementia, epilepsy, paralysis, stroke, syncope, traumatic head injury, and headache; we relate these symptoms with depictions of those conditions in the medical literature of the time. We also review Cervantes' sources of neurological information, including the works by renowned Spanish authors such as Juan Huarte de San Juan, Dionisio Daza Chacón and Juan Valverde de Amusco, and we hypothesize that Don Quixote's disorder was actually a neurological condition. Although Cervantes wrote it four centuries ago, Don Quixote contains plenty of references to neurology, and many of the ideas and concepts reflected in it are still of interest. Copyright © 2012 S. Karger AG, Basel.

  15. Don Quixote. [Lesson Plan].

    Science.gov (United States)

    Rooks, Kristen

    Based on Miguel de Cervantes' novel "Don Quixote," this lesson plan presents activities designed to help students understand that Quixote's misperceptions are understandable; writers often describe one object to sound as if it were something else; and metaphors help readers see with new eyes. The main activity of the lesson involves students…

  16. Don Quijote y Hamlet

    Directory of Open Access Journals (Sweden)

    Lúdovik B. Osterc

    2002-12-01

    Hamlet está loco, es un alucinado que duda de sus propios sentidos. Para él existe sólo un lado negro de la existencia, su único objeto es llegar más pronto al descubrimiento del crimen. Es egocentrico, ne cree en nada, eternamente mira en su interior, se alimenta en su desprecio de sí mismo y su sufrimiento es mucho más doloroso.que aquel de Don Quijote. Don Quijote, al contrario, cree en el hombre y su futuro. Su ideal es implantar por la fuerza, la verdad, el bien y la justicia en la tierra. Para servir a su ideal, está dispuesto a sufrir todas las posibles privaciones. Representa la fe en la verdad. Es ridículo y quizás el más cómico tipo disenado jamás por un literato. Hamlet es el hijo del rey muerte, mientras que Don Quijote está pobre. Se hace los enemigos imaginarios y lucha contra ellos, mientras que Hamlet no cree en las ilusiones (siempre duda, y tampoco no combatiría si supiera que son sinónimos de opresores. Continua con la examinación de la actitud del pueblo o sus representantes hacia Don Quijote y Hamlet y viceversa. Polonia es el representante de las multitudes populares ante Hamlet, Sancho lo es ante su senor. El primero es de sano pensamiento y al mismo tiempo un viejo charalatán. Para él Hamlet no es tanto un loco como un nino y le parece inútil para la sociedad. Sancho Pansa está persuadido de que su senor está loco, pero le está leal hasta la muerte. Don Quijote simpatiza profundamente con el pueblo, pero la única persona con la que se entiende verdaderamente es Sancho Pansa (uno no puede vivir sin otro. La actitud de Hamlet es completamente diferente, él desprecia las multitudes populares, porque también desprecia a sí mismo. social: el tedio, el hastío, el descontento de la vida, desorientación espiritual y la eclipse de la fe, miéntras que Don Quijote encarna el mundo libre, bien estar y la felicidad de los seres humanos. Por eso y porque es un ideal el más humano, generoso, noble y elevado, el autor del

  17. Biological and communication skills needed for introduced fish biologists

    Science.gov (United States)

    Bonar, Scott A.

    2016-01-01

    What skills and knowledge will a new graduate seeking employment need to work with introduced fishes? Clearly, success in introduced species management—similar to other disciplines in fisheries—requires a mixture of scientific and communication skills. However, specific abilities especially important to a biologist who manages introduced fishes should be highlighted. Unlike most other management strategies, stocking an introduced species can result in unintended and irreversible impacts, so particular care must be employed when stocking is considered. Furthermore, fish populations in areas outside of the introduced species management area might also be affected, usually negatively, if the introduced fish escapes. Therefore, rock-solid knowledge of basic aquatic ecology, including risk management; fish taxonomy (so the wrong fish species is not mistakenly stocked!); familiarity with human values of both the time and the place (which requires communication skills); and a strong understanding of human history are all important.

  18. "Don Quijote" im Film

    OpenAIRE

    Altenberg, Tilmann

    2007-01-01

    Wie kein zweiter Roman zieht der "Don Quijote" von Miguel de Cervantes seit nunmehr vier Jahrhunderten Generationen von Lesern immer wieder neu in seinen Bann. Abgefasst im Spanien des frühen 17. Jahrhunderts, das zu jener Zeit die Geschicke Europas wesentlich mitbestimmte, wurde der Roman bald zum Inbegriff der spanischen Literatur und Kultur. Von Madrid aus hat er auf den Rest Europas ausgestrahlt und Denker, Dichter, Künstler, Komponisten und später auch Filmemacher zur Auseinandersetzung ...

  19. Charles William Lacaillade. Biologist, Parasitologist, Educator, and Mentor.

    Science.gov (United States)

    Imperato, Pascal James

    2017-02-01

    Charles William Lacaillade (1904-1978) was an eminent biologist in the middle decades of the twentieth century. He was born in Lawrence, Massachusetts of parents whose ancestors were French Canadians. His father, also named Charles William Lacaillade, was a dentist who graduated from Tufts University School of Dentistry in 1898. His mother, Elodia Eno, came from a family of very successful businessmen. Lacaillade was the third of six children. His two older brothers, Harold Carleton and Hector Eno, both graduated from the University of Louisville, School of Dentistry, while his younger brother, Lawrence, became a businessman. His sister, Luemma, married Dr. Henry Steadman, a veterinarian, while his youngest sister, Gloria, married a U.S. Army officer, Lieutenant Colonel Victor Anido. Lacaillade received his MS and PhD degrees in biology and zoology from Harvard University. He then became a fellow at The Rockefeller Institute for Medical Research. At both institutions, he studied under some of the most eminent biological scientists of the time. These included Rudolf W. Glaser, George Howard Parker, Theobald Smith, Carl TenBroeck, and William Morton Wheeler. At the Rockefeller Institute, he co-discovered the vector and mode of transmission of Eastern Equine Encephalomyelitis. This discovery, and the research he conducted with Rudolf W. Glaser, quickly established him as an outstanding biological researcher. However, a change in leadership at the Rockefeller Institute resulted in research priorities being given to the disciplines of general physiology, physical chemistry, and nutrition. This shift in the research agenda away from the biological sciences precluded career advancement at the Rockefeller Institute for post-doctoral fellows like Lacaillade. It was the height of the Great Depression, and even biologists with terminal doctoral degrees found it difficult to find positions. In 1935, Lacaillade accepted a position as an assistant in biology at St. John

  20. Algo sobre el "Don" (Something about the Word "Don")

    Science.gov (United States)

    Pruneda, Armandino G.

    1975-01-01

    Discusses the many uses of the honorific title of "Don" in Spanish literature and Spanish colloquial speech. It may be used to joke and express irony, as in the expression "don ladron" (sir thief), and forms part of many idiomatic expressions. (Text is in Spanish.) (TL)

  1. Mimesis in Don Quixote

    Directory of Open Access Journals (Sweden)

    Giselle von der Walde

    2006-04-01

    Full Text Available Resumen:Frente a argumentos tomados de las poéticas neoaristotélicas que esgrime el canónigo para condenar los libros de caballerías, don Quijote pretende mostrar con su propio ejemplo, que ese tipo de lecturas no llevan a la locura ni al abandono de sí mismo, sino que, por el contrario, sacan lo mejor de la naturaleza de un individuo y lo hacen mejor persona. Este es el único tipo de imitación que Platón acepta en la República, pues más que un remedo o una suplantación, implica emulación. Este escrito se propone mirar, a partir del diálogo con el canónigo de Toledo (I, 49-50, cómo en sus conductas miméticas desde el comienzo de la obra, don Quijote entiende la imitación como emulación; en consecuencia se intenta demostrar que el efecto de la literatura en el caballero manchego parece ser el tipo de mimesis que Platón acepta en el libro III de la República.Abstract:Don Quijote demonstrates with the example of his own life the error made by the Canon of Toledo when the latter uses the arguments of the neo-Aristotelian poets to condemn the novels of chivalric romance. Quijote tries to show that reading the chivalric romances leads to neither madness nor the abandonment of the self, but, on the contrary, brings out the best in a person’s nature, and makes one a better person. This is the only type of imitation that Plato accepts in the Republic, because, unlike the mere copying of a person, or the substitution of one person for another, it implies a type of emulation. Starting with the dialogue of the Canon of Toledo (I, 49-50, this paper shows how, in his mimetic behavior, Don Quijote understands imitation as emulation. As a result, the paper shows that the effect of literature on the gentleman from La Mancha is the type of mimesis of which Plato approves in book III of the Republic.

  2. Don Isidoro Laverde Amaya

    Directory of Open Access Journals (Sweden)

    Carlos López Narváez

    1961-03-01

    Full Text Available A la calidad sustantiva de los polígrafos, -estirpe de los Vergara, Eduardo Posada, Gustavo Arboleda, Otero Muñoz, Samper Ortega, Gómez Restrepo para nombrar solo algunos de los que "nos han precedido con la señal de la fe", como dice el sacro ritual, y en el servicio de las Letras patrias- pertenece con mérito eximio el prócer de la bibliografía colombiana, don Isidoro Laverde Amaya.

  3. Don Leonardo, ¡magister!

    OpenAIRE

    Choza Armenta, Jacinto Luis

    2014-01-01

    1. Años de formación de don Leonardo. 2. Director de Estudios de la Facultad de Filosofía y Letras de la Universidad de Navarra. 3. Polo y su filosofía en los 70 y 80. 4. Maestro y consejero. 5. Personalidad. Cualidades y puntos ciegos. 6. Huérfano de don Leonardo. 1. Formative Years of Don Leonardo. 2. Director of Studies of the Faculty of Arts of the University of Navarra. 3. Polo and his philosophy in the 70s and 80s. 4. Teacher and counselor. 5. Personality. attributes and blind spots....

  4. Vaikne Don : [luuletused] / Mart Kangur

    Index Scriptorium Estoniae

    Kangur, Mart

    2004-01-01

    Sisu: Vaikne Don ; "Imelik, kui kerge on hakata armastama neid ..." ; "Laud otsekui tool ..." ; "Raamat on monument ..." ; "Nägu on liiga tühi ..." ; "Mida teeb Buddha pärast virgumist? Peseb hambaid ..."

  5. Les Don Juan français contemporains : de la crise du héros à celle de l’écriture

    Directory of Open Access Journals (Sweden)

    Aurélia Gournay

    2013-11-01

    Full Text Available Depuis sa création en Espagne, au 17ème siècle, le mythe de Don Juan a fait l’objet de constantes réécritures. Si le scénario mythique a su s’adapter à l’évolution des mentalités, les critères qui fondaient l’héroïsme donjuanesque ont dû, pour leur part, être redéfinis et c’est, bien souvent, comme un personnage problématique que Don Juan survit dans la littérature des 20ème et 21ème siècles. Cette mise à distance s’étend au champ de l’écriture puisque les œuvres intègrent, au sein de la fiction, des allusions à l’abondant discours critique que le héros inspire. Cette dimension métalittéraire, qui se double parfois d’une réflexion sur l’intertextualité et même sur le langage, en général, semble être une garantie de survie pour le mythe, qui parvient à se nourrir et à se renforcer de toutes les analyses formulées à son sujet, mais ne lui fait-elle pas aussi courir le risque d’une certaine forme de déconstruction ?

  6. Rejoice in the hubris: useful things biologists could do for physicists.

    Science.gov (United States)

    Austin, Robert H

    2014-10-08

    Political correctness urges us to state how wonderful it is to work with biologists and how, just as the lion will someday lie down with the lamb, so will interdisciplinary work, where biologists and physicists are mixed together in light, airy buildings designed to force socialization, give rise to wonderful new science. But it has been said that the only drive in human nature stronger than the sex drive is the drive to censor and suppress, and so I claim that it is OK for physicists and biologists to maintain a wary distance from each other, so that neither one censors or suppresses the wild ideas of the other.

  7. Embryotoxicity Caused by DON-Induced Oxidative Stress Mediated by Nrf2/HO-1 Pathway

    Directory of Open Access Journals (Sweden)

    Miao Yu

    2017-06-01

    Full Text Available Deoxynivalenol (DON belongs to the type B group of trichothecenes family, which is composed of sesquiterpenoid metabolites produced by Fusarium and other fungi in grain. DON may cause various toxicities, such as cytotoxicity, immunotoxicity, genotoxicity as well as teratogenicity and carcinogenicity. In the present study, we focus on a hypothesis that DON alters the expressions of Nrf2/HO-1 pathway by inducing embryotoxicity in C57BL/6 mouse (5.0, 2.5, 1.0, and 0 mg/kg/day and BeWo cell lines (0 and 50 nM; 3 h, 12 h and 24 h. Our results indicate that DON treatment in mice during pregnancy leads to ROS accumulation in the placenta, which results in embryotoxicity. At the same time Nrf2/HO-1 pathway is up-regulated by ROS to protect placenta cells from oxidative damage. In DON-treated BeWo cells, the level of ROS has time–effect and dose–effect relationships with HO-1 expression. Moderate increase in HO-1 protects the cell from oxidative damage, while excessive increase in HO-1 aggravates the oxidative damage, which is called in some studies the “threshold effect”. Therefore, oxidative stress may be the critical molecular mechanism for DON-induced embryotoxicity. Besides, Nrf2/HO-1 pathway accompanied by the “threshold effect” also plays an important role against DON-induced oxidative damage in this process.

  8. Microbial proteomics: a mass spectrometry primer for biologists

    Directory of Open Access Journals (Sweden)

    Graham Ciaren

    2007-08-01

    Full Text Available Abstract It is now more than 10 years since the publication of the first microbial genome sequence and science is now moving towards a post genomic era with transcriptomics and proteomics offering insights into cellular processes and function. The ability to assess the entire protein network of a cell at a given spatial or temporal point will have a profound effect upon microbial science as the function of proteins is inextricably linked to phenotype. Whilst such a situation is still beyond current technologies rapid advances in mass spectrometry, bioinformatics and protein separation technologies have produced a step change in our current proteomic capabilities. Subsequently a small, but steadily growing, number of groups are taking advantage of this cutting edge technology to discover more about the physiology and metabolism of microorganisms. From this research it will be possible to move towards a systems biology understanding of a microorganism. Where upon researchers can build a comprehensive cellular map for each microorganism that links an accurately annotated genome sequence to gene expression data, at a transcriptomic and proteomic level. In order for microbiologists to embrace the potential that proteomics offers, an understanding of a variety of analytical tools is required. The aim of this review is to provide a basic overview of mass spectrometry (MS and its application to protein identification. In addition we will describe how the protein complexity of microbial samples can be reduced by gel-based and gel-free methodologies prior to analysis by MS. Finally in order to illustrate the power of microbial proteomics a case study of its current application within the Bacilliaceae is given together with a description of the emerging discipline of metaproteomics.

  9. Kulturel liminalitet i Don Quixote

    DEFF Research Database (Denmark)

    Fastrup, Anne

    2007-01-01

    Med udgangspunkt i og i kontrast til nogle af hovedlinierne i den nyere litteratur om Don Quixote søger artiklen tilbage til de mere specifikke og lokale historiske forhold, som er romanens baggrund, bl.a. til Cervantes' »algierske erfaring« med tyrkisk fangenskab. Artiklen forsøger at kombinere...

  10. Don Quixote and Fifth Graders

    Science.gov (United States)

    Glass, Janet L.

    2006-01-01

    This article describes how the author makes the story of "Don Quixote de la Mancha" come alive to fifth graders in her Spanish class. She rewrote several scenes from the novel into short plays that were appropriate to the students' interests and to their novice-high proficiency level. The author chose a combination of scenes that offer…

  11. Modeling approaches in avian conservation and the role of field biologists

    Science.gov (United States)

    Beissinger, Steven R.; Walters, J.R.; Catanzaro, D.G.; Smith, Kimberly G.; Dunning, J.B.; Haig, Susan M.; Noon, Barry; Stith, Bradley M.

    2006-01-01

    This review grew out of our realization that models play an increasingly important role in conservation but are rarely used in the research of most avian biologists. Modelers are creating models that are more complex and mechanistic and that can incorporate more of the knowledge acquired by field biologists. Such models require field biologists to provide more specific information, larger sample sizes, and sometimes new kinds of data, such as habitat-specific demography and dispersal information. Field biologists need to support model development by testing key model assumptions and validating models. The best conservation decisions will occur where cooperative interaction enables field biologists, modelers, statisticians, and managers to contribute effectively. We begin by discussing the general form of ecological models—heuristic or mechanistic, "scientific" or statistical—and then highlight the structure, strengths, weaknesses, and applications of six types of models commonly used in avian conservation: (1) deterministic single-population matrix models, (2) stochastic population viability analysis (PVA) models for single populations, (3) metapopulation models, (4) spatially explicit models, (5) genetic models, and (6) species distribution models. We end by considering their unique attributes, determining whether the assumptions that underlie the structure are valid, and testing the ability of the model to predict the future correctly.

  12. Book Review of 'Modelling for Field Biologists and Other Interesting People' by Kokko, H

    Science.gov (United States)

    The article provides a review of the book, Modelling for Field Biologists and Other Interesting People, written by Hanna Kokko. The review is structured from the perspective of general interest in the topic rather than an assessment of the deep technical merits of the book. The review will be publ...

  13. Inhibitory Effect of Polysaccharides from Scutellaria barbata D. Don ...

    African Journals Online (AJOL)

    Available online at http://www.tjpr.org http://dx.doi.org/10.4314/tjpr.v12i4.11. Original Research Article. Inhibitory Effect of Polysaccharides from Scutellaria barbata D. Don on Invasion and Metastasis of 95-D Cells. Lines via Regulation of C-MET and E-CAD Expressions. Xiao-Kun Yang1,2, Ya-Dong Yang1, Shu-Qian Tang1, ...

  14. [Acute pain in "Don Quixote"].

    Science.gov (United States)

    Fraile, J R; de Miguel, A; Yuste, A

    2003-01-01

    A descriptive analysis of references to pain symptoms in Don Quixote based on linguistic, literary, clinical, and mannerist features. Don Quixote was read and an entry was created for each description of an injury or illness (group I/I). A second group of entries was created for each medical commentary (group C). This information was complemented using a computer search for the roots of words referring to pain symptoms, with an asterisk placed after each root to locate all word forms used. Data entries with pain references were analyzed in group I/I by examining patient, location, characteristics, causes, associated disorders, remedies, caregivers, and recovery times and in group C by examining the full text. Ninety-one entries were made (64 in group I/I, 27 in group c). References to pain were found in 37 entries (29 in group I/I, 8 in group C). The most commonly used words came from the roots dol (the Spanish root for dolor, or pain, among other related words) (52) and moli (for forms related to Spanish idiomatic uses of molido, suggesting severe injury) (19). All pains were due to injuries. Forty-two occasions of injury (Don Quixote 14, Sancho 9, others 19) and 51 lesions (ribs 5, back 5, other 15, unspecified 26) were mentioned. Known remedies and caregivers of the period were described, but other invented ones were also present. Associated disorders were insomnia, anxiety, rage, melancholy, functional impotence and other sexual dysfunctions. Recovery times ranged from 0 to 8 days. Pain references are subject to literary considerations. The style is simple and the descriptions are credible for the period depicted but do not meet clinical standards. Issues of current interest are treated: pain threshold and sensitivity, social influences, the placebo effect, and affective disorders.

  15. Don Germán

    Directory of Open Access Journals (Sweden)

    Juan Luis Mejía

    1991-01-01

    Full Text Available El veranillo de San Juan hace soportable el mediodía. Los "chorros d'oro" inundan de amarillo los antejardines del Prado. Las golondrinas veraneras invaden, al atardecer, los alrededores de la Biblioteca Departamental. Los voceadores de la suerte del paseo Bolívar claman a los cuatro vientos el número que cambiará su destino . Pero algo falta definitivamente en esta Barranquilla. De alguna manera la ciudad ya no es la misma. Falta Don Germán.

  16. [Don Quijote, a lucid mad].

    Science.gov (United States)

    Alonso Fernández, Francisco

    2004-01-01

    The case of a 50-year-old hidalgo who believed to be transformed into a knight-errant named Don Quijote is a megalomaniac systematized delusion of transformation of the self, a delusion of metamorphosis in reference to the patient's own identity. The outward projection of this syndrome produces some delusional misidentifications of others, things and animals and include elements of a persecutory delusion which increase the grandiosity of the self. At the same time the hidalgo was maniac with a pathway of bipolar disorder. The phenomenon of donquijotismo is described as the defence of wasted causes and Sancho Panza as an illiterate Sócrates.

  17. Postphenomenology - "Festschrift" for Don Ihde

    DEFF Research Database (Denmark)

    Riis, Søren

    2008-01-01

    What do underwater animals, artificial limbs, and a wrecked space shuttle have in common?  Where do the humanities and the natural sciences intersect?  Is technology a Leviathan in our midst, an aid that stabilizes and protects our fragile biology, or an instrument that propels us ever closer...... to salvation?  Through a lifetime of thinking, probing, and experimenting, Don Ihde has brought such questions to our attention and has generously been offering his insights to interlocutors across the disciplines.  Postphenomenology: A Critical Companion to Ihde is an extraordinary volume, not least because...

  18. Educational background and professional participation by federal wildlife biologists: Implications for science, management, and The Wildlife Society

    Science.gov (United States)

    Schmutz, Joel A.

    2002-01-01

    Over 2,000 people are employed in wildlife biology in the United States federal government. The size of this constituency motivated me to examine the amount of formal education federal biologists have received and the extent of continuing education they undertake by reading journals or attending scientific meetings. Most federal biologists who are members of The Wildlife Society (TWS) have a graduate degree. However, one-third have only a Bachelor of Science degree, despite the current trend toward hiring people with graduate degrees. Most federal biologists are not research biologists. Numbers of journals subscribed to was positively related to educational level. Less than one-third of all wildlife biologists employed by the United States Fish and Wildlife Service are members of TWS or subscribe to any of its journals. In contrast, the majority of presenters at the TWS 2000 Annual Conference were research biologists and members of TWS. The failure of many federal wildlife biologists to read scientific literature or attend professional meetings indicates a failure to promote the importance of continuing education in the federal workplace. I identify 2 potential adverse impacts of this failing: an inability to recognize important and relevant scientific contributions and an ineffectiveness in carrying out adaptive management.

  19. Fighting for life: Religion and science in the work of fish and wildlife biologists

    Science.gov (United States)

    Geffen, Joel Phillip

    Philosophers, historians, and sociologists of science have argued that it is impossible to separate fact from value. Even so, Americans generally demand that scientists be "objective." No bias is permitted in their work. Religious motivations in particular are widely considered anathema within the halls of science. My dissertation addresses both theoretical and practical aspects concerning objectivity in science through an examination of fish and wildlife biologists. I hypothesized that they use the language of objective science as a tool to convince others to protect habitats and species. Further, I claimed that this "rhetoric of science" is employed either consciously or unconsciously on behalf of personal values, and that religious and/or spiritual values figure significantly among these. Regarding the issue's practical applications, I argued in support of Susan Longino's assertion that while subjective influences exist in science, they do not necessarily indicate that objectivity has been sacrificed. My primary methodology is ethnographic. Thirty-five biologists working in the Pacific Northwest were interviewed during the course of summer 2001. Participant ages ranged from 23 to 78. Both genders were represented, as were various ethnic and cultural backgrounds, including Native American. I used a questionnaire to guide respondents through a consistent set of open-ended queries. I organized their answers under four categories: the true, the good, the beautiful, and the holy. The first three were borrowed from the theoretical writings of philosopher Immanuel Kant. The last came from Rudolf Otto's theological work. These categories provided an excellent analytical framework. I found that the great majority of fish and wildlife biologists strive for objectivity. However, they are also informed by powerful contextual values. These are derived from environmental ethics, aesthetic preferences pertaining to ecosystem appearance and function, and visceral experiences of

  20. “Is that right?” – Don Favareau, Don Corleone & the semiotics of friendship

    DEFF Research Database (Denmark)

    Emmeche, Claus

    2017-01-01

    A chapter commenting specifically on John Poinsot's "Tractatus de Signis", John Deely's interpretation of Poinsot's mentioning of "friendship" as an example of a triadic relation, Don Favareau's contribution to the biosemiotic community, and Don Corleone as a symbol of a different kind of "friend......A chapter commenting specifically on John Poinsot's "Tractatus de Signis", John Deely's interpretation of Poinsot's mentioning of "friendship" as an example of a triadic relation, Don Favareau's contribution to the biosemiotic community, and Don Corleone as a symbol of a different kind...... of "friendship", and generally on the philosophy of friendship....

  1. Why I'm Not a Cognitive Psychologist... or a Behaviorist... or a Biologist.

    Science.gov (United States)

    Garcia, Erik J

    2017-10-18

    "Science" is under increasing amounts of scrutiny. Concerns about reproducibility, reduced institutional support, and intensified competition has been highlighted in recent years, but segregated science endangers scientific discovery above all. Segregated science can be interdisciplinary (biology vs psychology) or intradisciplinary (behaviorism vs cognitive psychology). The advancement of science and public knowledge depends on the unification of all disciplines to better understand the phenomena scientists study. We suggest that engendering collaborations across scientific disciplines produces better-designed research and appropriate interpretations, and increases career-long success. I am not a cognitive psychologist, behaviorist, or biologist because I am a neuroscientist.

  2. Don Zhuanu otdajutsja tolko po ljubvi

    Index Scriptorium Estoniae

    2006-01-01

    Eestisse tuleb külla Roman Viktjuki Teater, 1. nov. mängitakse Vene Kultuurikeskuses Jean Genet' "Toatüdrukuid" (lavastaja Roman Viktjuk), 23. nov. etendatakse Eric-Emmanuel Scmitti "Don Juani viimast armastust" (lavastaja Roman Viktjuk)

  3. Don't Take This with That!

    Medline Plus

    Full Text Available ... Tobacco Products Drugs Home Drugs Resources for You Special Features Don't take this with that! Share ... Drug Interactions: What You Should Know More in Special Features Page Last Updated: 12/17/2015 Note: ...

  4. Don Quixote, a critical (and apologetic adventure

    Directory of Open Access Journals (Sweden)

    Luís Garcia Soto

    2017-08-01

    Full Text Available In this text, I intend to interpret Cervantes’s Don Quixote from a moral point of view. I use two categories that I borrow from Adorno’s conception of philosophy: criticism and apology. In my view, in Don Quixote’s perception of reality there is an idea of justice that implies an ideology that includes some transgressing elements in relation with the morals and politics of his historical context. I connect these transgressing elements with two outstanding contributions of modern Iberian thought: ius gentium and casuistry. In my view, Don Quixote fights for peace and understanding in politics and for freedom of consciousness in morals. He wrestles with a political and moral construction of reality. Apparently, he always fails. But, in his failures, sometimes he wins and sometimes he loses. On the one hand, Don Quixote wins whenever he struggles with a fact: he misunderstands it and he reacts according with his view, but, in doing that, he shows that a change is possible in a moral and political state of facts. Don Quixote’s defeat conveys a way of criticism: he launched an attack on the social construction of reality held and kept by the establishment of his time. On the other hand, Don Quixote loses when he struggles with an idol of theatre: he misunderstands it too, and he doesn’t realize that it is a creation of established powers. In those cases, his defeats imply a double victory of the establishment: in the order of facts and in the order of beliefs. In these cases, Don Quixote’s defeat means an apology of the establishment of his time. But, even in that case, it is possible to deconstruct this apology. By way of Cervantes’ humour, readers can deconstruct this apology and see criticism in Don Quixote’s adventure.

  5. Demystifying animal 'personality' (or not): why individual variation matters to experimental biologists.

    Science.gov (United States)

    Roche, Dominique G; Careau, Vincent; Binning, Sandra A

    2016-12-15

    Animal 'personality', defined as repeatable inter-individual differences in behaviour, is a concept in biology that faces intense controversy. Critics argue that the field is riddled with terminological and methodological inconsistencies and lacks a sound theoretical framework. Nevertheless, experimental biologists are increasingly studying individual differences in physiology and relating these to differences in behaviour, which can lead to fascinating insights. We encourage this trend, and in this Commentary we highlight some of the benefits of estimating variation in (and covariation among) phenotypic traits at the inter- and intra-individual levels. We focus on behaviour while drawing parallels with physiological and performance-related traits. First, we outline some of the confusion surrounding the terminology used to describe repeatable inter-individual differences in behaviour. Second, we argue that acknowledging individual behavioural differences can help researchers avoid sampling and experimental bias, increase explanatory power and, ultimately, understand how selection acts on physiological traits. Third, we summarize the latest methods to collect, analyse and present data on individual trait variation. We note that, while measuring the repeatability of phenotypic traits is informative in its own right, it is only the first step towards understanding how natural selection and genetic architecture shape intra-specific variation in complex, labile traits. Thus, understanding how and why behavioural traits evolve requires linking repeatable inter-individual behavioural differences with core aspects of physiology (e.g. neurophysiology, endocrinology, energy metabolism) and evolutionary biology (e.g. selection gradients, heritability). © 2016. Published by The Company of Biologists Ltd.

  6. Health hazards of "don't ask, don't tell".

    Science.gov (United States)

    Katz, Kenneth A

    2010-12-16

    While U.S. courts consider a lawsuit alleging that the military's "don't ask, don't tell" policy violates the rights of gay and lesbian service members, the policy continues to jeopardize the health of those service members, the military, and the country at large.

  7. Don\\'t Ask, Don\\'t Tell: Ethical Issues Concerning Learning and ...

    African Journals Online (AJOL)

    Informed consent procedures and requirements must be clearly established and communicated. The learning and proficiency practices should be restricted to the staff that can truly benefit from the experience. The practice of 'don't ask, don't tell' is not an option. South African Journal of Family Practice Vol. 50 (4) 2008: pp.

  8. Guidelines : the do's, don'ts and don't knows of feedback for clinical education

    NARCIS (Netherlands)

    Lefroy, Janet; Watling, Chris; Teunissen, Pim W; Brand, Paul

    2015-01-01

    INTRODUCTION: The guidelines offered in this paper aim to amalgamate the literature on formative feedback into practical Do's, Don'ts and Don't Knows for individual clinical supervisors and for the institutions that support clinical learning. METHODS: The authors built consensus by an iterative

  9. Buscando a don Claudio Moyano

    Directory of Open Access Journals (Sweden)

    Juan González Ruiz

    2009-12-01

    Full Text Available (ES En el primer número de esta revista digital "Cabás", Antonio Montero Alcalde hizo un pormenorizado y útil análisis de la llamada Ley Moyano, la Ley de Instrucción Pública promulgada en 1857; la importancia de este texto legal en el desarrollo de la educación en España a lo largo de más de un siglo ha sido puesta de relieve en multitud de estudios históricos referidos a la época contemporánea. Nacido en una pequeña población zamorana el día 30 de octubre de 1809, la vida pública de don Claudio Moyano Samaniego, el firmante de la ley que lleva su nombre, se desarrolló básicamente en la corte madrileña; no obstante, rastrear en el entorno de su tierra natal algunos aspectos y circunstancias de su persona puede tener interés para completar la figura de una personalidad tan citada por su obra como desconocida por su vida. Y, al menos, sirve como curioso entretenimiento de un impenitente viajero a la búsqueda de huellas históricas de las escuelas de otros tiempos y de los hombres dedicados a ellas.

  10. Don Quixote: Freud and Cervantes.

    Science.gov (United States)

    Beá, J; Hernández, V

    1984-01-01

    We have focused this paper on an attempt to examine the process occurring in the transformations which Alonso Quijano undergoes when becoming Don Quixote as an expression of his disturbance, and the evolution at work during his travels to dissipate his grandiose narcissism by means of a cure of humiliation which makes him humble and able to recognize dependence and internal conflicts, finally culminating in the working through of the depressive position and the resolution of the prior schizo-paranoid phase just before his death. The disturbances of Alonso Quijano begin when he is faced with the anxieties provoked by approaching old age and death. The internal conflict over not-worked through mournings may lead to making reparations and to the stimulus of creativity and towards maturity. Badly resolved, it progresses to involutive psychosis which may result in psychotic destruction. Cervantes creates a 'hero' whom he treats in humorous and tragicomic ways, a hero who rises regressively from his unresolved Oedipus conflict, and with the traits of a grandiose self and with the need to 'repair' the projected image, deforming reality and at the same time being slowly obliged to take it into account.

  11. The biologist as psychologist: Henry Fairfield Osborn's early mental ability investigations.

    Science.gov (United States)

    Young, Jacy L

    2012-01-01

    In the early 1880s, biologist Henry Fairfield Osborn conducted some of the first questionnaire research in American psychology. This article details how he came to distribute Francis Galton's questionnaire on mental imagery in the United States, as well as how he altered it to suit his own burgeoning psychological research interests. The development and circulation of questionnaires at the very beginning of American scientific psychology, first by Osborn and later by G. Stanley Hall, is discussed in terms of the new psychology's often-overlooked methodological plurality. Further, Osborn's late nineteenth century interest in individual variation and group differences in mental imagery ability are discussed in relation to his pervasive educational and social concerns, as well as his eventual status as a prominent eugenicist in the twentieth century United States. This research into mental imagery ability foreshadows the eugenic-oriented intelligence testing that developed in the early twentieth century. © 2012 Wiley Periodicals, Inc.

  12. Values and attitudes of National Wildlife Refuge managers and biologists; Report to respondents

    Science.gov (United States)

    Brinson, Ayeisha A.; Benson, Delwin E.

    2002-01-01

    The issues affecting natural resource management, the society in which natural resource management occurs, natural resource agency personnel, and the publics they serve have changed in recent decades. Previous studies of Refuge professionals in the U.S. Fish and Wildlife Service (Service) have revealed that employees lack strong commitment to the current organizational structure, were frustrated with the lack of communication within the agency and felt there was a need for strong leadership (PEER 1998, 1999). These results prompted the authors to have further questions about refuge management in the Fish and Wildlife Service. What do employees value about their agency? Is there a difference in values between refuge managers and biologists and if so, what are those differences and what influences those differences?

  13. CWM Global Search—The Internet Search Engine for Chemists and Biologists

    Directory of Open Access Journals (Sweden)

    Hans-Jürgen Himmler

    2010-12-01

    Full Text Available CWM Global Search is a meta-search engine allowing chemists and biologists to search the major chemical and biological databases on the Internet, by structure, synonyms, CAS Registry Numbers and free text. A meta-search engine is a search tool that sends user requests to several other search engines and/or databases and aggregates the results into a single list or displays them according to their source [1]. CWM Global Search is a web application that has many of the characteristics of desktop applications (also known as Rich Internet Application, RIA, and it runs on both Windows and Macintosh platforms. The application is one of the first RIA for scientists. The application can be started using the URL http://cwmglobalsearch.com/gsweb.

  14. The Washington Biologists' Field Club : Its members and its history (1900-2006)

    Science.gov (United States)

    Perry, M.C.

    2007-01-01

    This book is based on the interesting one-hundred-plus-year history of the Club and its members. Plummers Island and the historic cabin on the Island have served as a common meeting area where the Club members have conducted research and held many social activities for over a century. The history has been written and revised over the years by members, and the biographical sketches also have been collected and written by the members. The Club was formed in 1900 and incorporated as a society in 1901 for scientists in the Washington, D.C., area. In recent years the Club has sponsored research by many non-member local scientists with grants totaling over $305,000. The cumulative total of 267 members represents all branches of natural science, with a strong emphasis on biology as the Club name indicates. In addition to the biologists there have been famous naturalists (e.g., John Burroughs), high-level administrators (e.g., Ira Gabrielson), and well-known artists (e.g., Roger Tory Peterson). Most members have been biological scientists, working for agencies in the Washington, D.C., area, who have published many articles and books dealing with biology and related subjects. The book is publIshed mainly for the benefit of the living Club members and for relatives of the deceased members. The members hope that the book will find its way into libraries across the country and that in the future, persons interested in some of the pioneer scientists, in the various professional areas of science, can obtain biographical information from a well-documented source. Most of the 542 illustrations of the members, cabin, and the Island have not been published previously. It is hopeful that the biographical sketches, pictures, and other information presented in this book can generate new information for future publications and for the website of the Washington Biologists' Field Club, which is updated frequently.

  15. GeneNotes – A novel information management software for biologists

    Directory of Open Access Journals (Sweden)

    Wong Wing H

    2005-02-01

    Full Text Available Abstract Background Collecting and managing information is a challenging task in a genome-wide profiling research project. Most databases and online computational tools require a direct human involvement. Information and computational results are presented in various multimedia formats (e.g., text, image, PDF, word files, etc., many of which cannot be automatically processed by computers in biologically meaningful ways. In addition, the quality of computational results is far from perfect and requires nontrivial manual examination. The timely selection, integration and interpretation of heterogeneous biological information still heavily rely on the sensibility of biologists. Biologists often feel overwhelmed by the huge amount of and the great diversity of distributed heterogeneous biological information. Description We developed an information management application called GeneNotes. GeneNotes is the first application that allows users to collect and manage multimedia biological information about genes/ESTs. GeneNotes provides an integrated environment for users to surf the Internet, collect notes for genes/ESTs, and retrieve notes. GeneNotes is supported by a server that integrates gene annotations from many major databases (e.g., HGNC, MGI, etc.. GeneNotes uses the integrated gene annotations to (a identify genes given various types of gene IDs (e.g., RefSeq ID, GenBank ID, etc., and (b provide quick views of genes. GeneNotes is free for academic usage. The program and the tutorials are available at: http://bayes.fas.harvard.edu/genenotes/. Conclusions GeneNotes provides a novel human-computer interface to assist researchers to collect and manage biological information. It also provides a platform for studying how users behave when they manipulate biological information. The results of such study can lead to innovation of more intelligent human-computer interfaces that greatly shorten the cycle of biology research.

  16. Genio y figura de don Alfonso Reyes

    Directory of Open Access Journals (Sweden)

    Eduardo Carranza

    1968-04-01

    Full Text Available Entre varias, escojo esta: por sobria y conmovida a un tiempo. La escribió Juan Fernández Figueroa para su revista " Indice", de Madrid. Nos parece ver a don Alfonso en el rellano de la escalera -al fondo, sus libros; más allá, toda su vida, noble y pura- nos parece verle por última vez, inclinado ya sobre la baranda de la muerte. Tiene la calidad y el dinamismo de unos cuantos dibujos rápidos, nerviosos, esta imagen última de don Alfonso Reyes.

  17. Stability of DON and DON-3-glucoside during baking as affected by the presence of food additives.

    Science.gov (United States)

    Vidal, Arnau; Sanchis, Vicente; Ramos, Antonio J; Marín, Sonia

    2018-03-01

    The mycotoxin deoxynivalenol (DON) is one of the most common mycotoxins of cereals worldwide, and its occurrence has been widely reported in raw wheat. The free mycotoxin form is not the only route of exposure; modified forms can also be present in cereal products. Deoxynivalenol-3-glucoside (DON-3-glucoside) is a common DON plant conjugate. The mycotoxin concentration could be affected by food processing; here, we studied the stability of DON and DON-3-glucoside during baking of small doughs made from white wheat flour and other ingredients. A range of common food additives and ingredients were added to assess possible interference: ascorbic acid (E300), citric acid (E330), sorbic acid (E200), calcium propionate (E282), lecithin (E322), diacetyltartaric acid esters of fatty acid mono- and diglycerides (E472a), calcium phosphate (E341), disodium diphosphate (E450i), xanthan gum (E415), polydextrose (E1200), sorbitol (E420i), sodium bicarbonate (E500i), wheat gluten and malt flour. The DON content was reduced by 40%, and the DON-3-glucoside concentration increased by >100%, after baking for 20 min at 180°C. This confirmed that DON and DON-3-glucoside concentrations can vary during heating, and DON-3-glucoside could even increase after baking. However, DON and DON-3-glucoside are not affected significantly by the presence of the food additives tested.

  18. The rise of repeal: policy entrepreneurship and Don't Ask, Don't Tell.

    Science.gov (United States)

    Neff, Christopher L; Edgell, Luke R

    2013-01-01

    We report on policy entrepreneurship by Servicemembers Legal Defense Network (SLDN) and how its legislative strategies used mini-windows of opportunity to shift Capitol Hill perspectives of Don't Ask, Don't Tell (DADT) from political plutonium to an emerging issue requiring a second look. Four phases in the legislative history of DADT are identified: radioactive, contested, emerging, and viable. In all, this article argues that SLDN's entrepreneurship focused on contesting congressional sensibilities to wait or defer on repeal, maintained that every discharge was damaging and transitioned toward a post-repeal mind set. Finally, we illustrate the importance of these transitions by comparing SLDN's 2004 estimated vote count for the introduction of the Military Readiness Enhancement Act with the final 2010 voting results on the Don't Ask, Don't Tell Repeal Act.

  19. Measuring, interpreting, and responding to changes in coral reefs: A challenge for biologists, geologist, and managers

    Science.gov (United States)

    Rogers, Caroline S.; Miller, Jeff; Hubbard, Dennis K.; Rogers, Caroline S.; Lipps, Jere H.; Stanley, George D.

    2016-01-01

    What, exactly, is a coral reef? And how have the world’s reefs changed in the last several decades? What are the stressors undermining reef structure and function? Given the predicted effects of climate change, do reefs have a future? Is it possible to “manage” coral reefs for resilience? What can coral reef scientists contribute to improve protection and management of coral reefs? What insights can biologists and geologists provide regarding the persistence of coral reefs on a human timescale? What is reef change to a biologist… to a geologist?Clearly, there are many challenging questions. In this chapter, we present some of our thoughts on monitoring and management of coral reefs in US national parks in the Caribbean and western Atlantic based on our experience as members of monitoring teams. We reflect on the need to characterize and evaluate reefs, on how to conduct high-quality monitoring programs, and on what we can learn from biological and geological experiments and investigations. We explore the possibility that specific steps can be taken to “manage” coral reefs for greater resilience.

  20. The Princeton Protein Orthology Database (P-POD: a comparative genomics analysis tool for biologists.

    Directory of Open Access Journals (Sweden)

    Sven Heinicke

    2007-08-01

    Full Text Available Many biological databases that provide comparative genomics information and tools are now available on the internet. While certainly quite useful, to our knowledge none of the existing databases combine results from multiple comparative genomics methods with manually curated information from the literature. Here we describe the Princeton Protein Orthology Database (P-POD, http://ortholog.princeton.edu, a user-friendly database system that allows users to find and visualize the phylogenetic relationships among predicted orthologs (based on the OrthoMCL method to a query gene from any of eight eukaryotic organisms, and to see the orthologs in a wider evolutionary context (based on the Jaccard clustering method. In addition to the phylogenetic information, the database contains experimental results manually collected from the literature that can be compared to the computational analyses, as well as links to relevant human disease and gene information via the OMIM, model organism, and sequence databases. Our aim is for the P-POD resource to be extremely useful to typical experimental biologists wanting to learn more about the evolutionary context of their favorite genes. P-POD is based on the commonly used Generic Model Organism Database (GMOD schema and can be downloaded in its entirety for installation on one's own system. Thus, bioinformaticians and software developers may also find P-POD useful because they can use the P-POD database infrastructure when developing their own comparative genomics resources and database tools.

  1. Perspectives of biologists, epidemiologists and geneticists' controversies in sciences and health system reforms.

    Science.gov (United States)

    Huttin, Christine C

    2015-01-01

    The global burden of diseases is predicted to increase considerably in the coming decades (GBD project, WHO, 2010 [1]) - WHO-World Bank study, 1991 [2]); for example, the World Alzheimer Report and the UN Declaration on Non-Communicable Diseases estimate that the burden associated with dementia will increase 2-fold by 2030 and 3-4-fold by 2050. Therefore, urgent needs must be met in order to help policy-makers deal with the increasing societal costs of diseases. Recent technologies can facilitate the detection and prevention of mild cases of cognitive impairments, or integrative genomic medicine can target more individualized genetic traits and pedigrees; however, scientists do not necessarily agree: results from a recent population-based study using population imaging [3] differed from results obtained using integrative genomics approaches [4], and controversy exists between molecular biologists [5,6] and geneticists [7,8] with respect to asthma genetics. These differences have led to different predictive disease models and can influence the assessment of aging and environmental modifiers. This paper highlights implications for the governance of health systems using current debates on the evolution of these major fields of science. In addition, this paper discusses the potential translation of these models for use in clinical practice, particularly with telemedicine and telecare dominated by new IT technologies and challenges of science in transition.

  2. The "don't ask, don't tell" policy and military performance.

    Science.gov (United States)

    Bonner, Kimberly B; Segal, David R

    2005-08-01

    This paper is a response to Schumm's 2004 critique of Belkin's 2003 article, dealing with the "Don't Ask, Don't Tell" policy in the U.S. military. Schumm's critique specified four reasons for continuing to exclude homosexuals from military service: military effectiveness, sexual asymmetries, Christian soldiers' dilemma of "living a lie" and skewed opinions of policy makers and military elites. Each of these categories is analyzed and discussed.

  3. Guidelines: the do's, don'ts and don't knows of feedback for clinical education.

    Science.gov (United States)

    Lefroy, Janet; Watling, Chris; Teunissen, Pim W; Brand, Paul

    2015-12-01

    The guidelines offered in this paper aim to amalgamate the literature on formative feedback into practical Do's, Don'ts and Don't Knows for individual clinical supervisors and for the institutions that support clinical learning. The authors built consensus by an iterative process. Do's and Don'ts were proposed based on authors' individual teaching experience and awareness of the literature, and the amalgamated set of guidelines were then refined by all authors and the evidence was summarized for each guideline. Don't Knows were identified as being important questions to this international group of educators which if answered would change practice. The criteria for inclusion of evidence for these guidelines were not those of a systematic review, so indicators of strength of these recommendations were developed which combine the evidence with the authors' consensus. A set of 32 Do and Don't guidelines with the important Don't Knows was compiled along with a summary of the evidence for each. These are divided into guidelines for the individual clinical supervisor giving feedback to their trainee (recommendations about both the process and the content of feedback) and guidelines for the learning culture (what elements of learning culture support the exchange of meaningful feedback, and what elements constrain it?) Feedback is not easy to get right, but it is essential to learning in medicine, and there is a wealth of evidence supporting the Do's and warning against the Don'ts. Further research into the critical Don't Knows of feedback is required. A new definition is offered: Helpful feedback is a supportive conversation that clarifies the trainee's awareness of their developing competencies, enhances their self-efficacy for making progress, challenges them to set objectives for improvement, and facilitates their development of strategies to enable that improvement to occur.

  4. Don Quijote en Canadá

    Directory of Open Access Journals (Sweden)

    Cristina Botella González

    2007-01-01

    Full Text Available Conocer a Cervantes y su obra.- Descubrir otros países y artistas.- Conocer al personaje de Don Quijote.- Familiarizarse con los personajes principales.- Relacionar la pintura y la literatura.- Desarrollar habilidades manuales y artísticas.- Potenciar la creatividad.

  5. Hepatoprotective Effect of Adenema hyssopifolium G. Don ...

    African Journals Online (AJOL)

    Purpose: The effects of oral administration of ethyl acetate, ethanol and aqueous extracts of Adenema hyssopifolium G.Don (Gentianaceae) on carbon tetrachloride-induced liver disorders were investigated. Methods: Rats were individually treated daily with 300 and 600 mg/kg dose of either ethyl acetate, ethanol or ...

  6. Don't Take This with That!

    Medline Plus

    Full Text Available ... Español Search FDA Submit search Popular Content Home Food Drugs Medical Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Drugs Home Drugs Resources for You Special Features Don't ...

  7. Don't Take This with That!

    Medline Plus

    Full Text Available ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Drugs Home Drugs Resources for You Special Features Don't take ... worth the squeeze…especially when combining grapefruit with medicines. While it can be part of a balanced ...

  8. The Don Henry Story. Teaching with Documents.

    Science.gov (United States)

    National Archives and Records Administration, Washington, DC.

    Don Henry was a student at the University of Kansas (Lawrence, Kansas) who experienced a profound political change during his years on campus. Henry became a leader in radical campus organizations, volunteered to fight in the Spanish Civil War with the Lincoln Brigade, and died on the battlefield in Aragon (Spain) in September 1937. An article in…

  9. Don Juan on manipulaator / Kai Ilustrumm

    Index Scriptorium Estoniae

    Ilustrumm, Kai

    2004-01-01

    Nüüdisaegne muusikalis-koreograafiline fantaasia "Don Juani pidusöök" Kanuti Gildi Saalis. Eesti tantsijate ja hollandi muusikute Holland Windplayers koostöös sündinud projekti tutvustab Tallinna Filharmoonia sarja "Diplomaadilised noodid" juht Heli Vaus-Tamm

  10. Don Quixote at 400: Still Conquering Hearts

    Science.gov (United States)

    Stavans, Ilan

    2005-01-01

    The Knight of the Sorrowful Countenance is turning 400. By some accounts, the first part of Don Quixote, Miguel de Cervantes's masterpiece, was available in Valladolid by Christmas Eve 1604, although Madrid did not get copies until January 1605. Thus came to life the "ingenious gentleman" who, ill equipped with antiquated armor "stained with rust…

  11. Cervantes and the Lirical Poetry: Don Quixote

    Directory of Open Access Journals (Sweden)

    Fernando Romo Feito

    2012-12-01

    Full Text Available This essay examines the lyrical poems included in the first and the second part of Don Quixote. The different classes of poems are studied attending to its narrative context. But the poetry is also studied by relating it with metrical and aesthetical categories: Realism, Parody, Manierism…

  12. Don Quijote en Canadá

    OpenAIRE

    Botella González, Cristina

    2007-01-01

    Conocer a Cervantes y su obra. - Descubrir otros países y artistas. - Conocer al personaje de Don Quijote. - Familiarizarse con los personajes principales. - Relacionar la pintura y la literatura. - Desarrollar habilidades manuales y artísticas. - Potenciar la creatividad.

  13. Don Quijote en Canadá

    OpenAIRE

    Cristina Botella González

    2012-01-01

    Conocer a Cervantes y su obra. - Descubrir otros países y artistas. - Conocer al personaje de Don Quijote. - Familiarizarse con los personajes principales. - Relacionar la pintura y la literatura. - Desarrollar habilidades manuales y artísticas. - Potenciar la creatividad.

  14. Don't Take This with That!

    Medline Plus

    Full Text Available ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Drugs Home Drugs Resources for You Special Features Don't take ... more than fifty prescription and over-the-counter drugs known to the U.S. Food and Drug Administration ...

  15. On the effects of the Fusarium toxin deoxynivalenol (DON) administered per os or intraperitoneal infusion to sows during days 63 to 70 of gestation.

    Science.gov (United States)

    Goyarts, Tanja; Brüssow, Klaus-Peter; Valenta, Hana; Tiemann, Ute; Jäger, Kathrin; Dänicke, Sven

    2010-05-01

    Six pregnant sows of 180.6 ± 5.6 kg were fed either a Fusarium-contaminated (4.42 mg DON and 48.3 µg ZON per kg, DON per os, n = 3) or a control diet (0.15 mg DON and 5 µg ZON/kg) in the period of days 63 and 70 of gestation. On day 63 of gestation, sows fed the control diet were implanted with an intraperitoneal osmotic minipump (delivery rate of 10 µL/h, for 7 days) containing 50 mg pure (98%) DON in 2 ml 50% DMSO (DON ip, n = 3). Frequent plasma samples were taken to estimate the kinetics after oral and ip DON exposure. The intended continuous delivery of DON by the intraperitoneal minipump could not be shown, as there was a plasma peak (Cmax) of 4.2-6.4 ng DON/mL either immediately (sow IP-2+3) or 2.5 h (sow IP-1) after implantation of the pump followed by a one-exponential decline with a mean half-time (t1/2) of 1.75-4.0 h and only negligible DON plasma concentrations after 12 h. Therefore, the DON ip exposure has to be regarded as one single dose 1 week before termination of experiment. The DON per os sows showed a mean basis level (after achieving a steady state) of DON plasma concentration of about 6-8 ng/mL, as also indicated by the plasma DON concentration at the termination of the experiment. On day 70, caesarean section was carried out, the fetuses were killed immediately after birth, and samples of plasma, urine, and bile were taken to analyze the concentration of DON and its metabolite de-epoxy-DON. At necropsy there were no macroscopic lesions observed in any organ of either sows or piglets. Histopathological evaluation of sows liver and spleen revealed no alterations. The proliferation rate of peripheral blood mononuclear cells (PBMC) with or without stimulation was not affected by the kind of DON treatment. The exposure of pregnant sows at mid-gestation (days 63-70, period of organogenesis) to a Fusarium toxin-contaminated diet (4.42 mg DON and 0.048 mg ZON per kg) or pure DON via intraperitoneal osmotic minipump

  16. [Discreet follies. Variations on Don Quixote's folly].

    Science.gov (United States)

    Gracia Guillén, Diego

    2005-01-01

    Physicians and psychiatrists have been discussing through centuries about the madness of Don Quixote. The first in doing that was Philippe Pinel, followed immediately by many others. They all agreed in diagnosing Don Quixote as "monomaniac". Cervantes was considered an excellent "nosographer", and the novel a paradigmatic description of this mental disorder. After the Kraepelin's work, the old Pinelian nosography was substituted by a new system of classification of mental diseases, and Don Quixote was considered "paranoid". Finally, after the DSM IV, the usual diagnostic is "delusional disorder". Throughout history there have been two different types of mental disorders, being only one of them considered pathological. This difference appears in English in words like "crazy" and "mad." The thesis of this essay is that Don Quixote is more a crazy than a mad man. He is trying to achieve a world full of peace, justice and love. His moral ideal is to make possible the triumph of this perfect world. This crazy goal was deeply influenced by the Erasmian ideology. And Erasmus of Rotterdam was the author of a very famous book entitled The Praise of Folly, published the year 1509, almost a century before the novel of Cervantes. In this work, the word opposite to "loco" (crazy, mad, insane) is "discreto", a word of difficult translation to English, which means at the same time "shrewd," "discreet" and "ingenious". Cervantes says at the beginning of the second part of his work, that Don Quixote is doing in it "discretas locuras" ("discreet follies", trans. Thomas Shelton, 1620; "ingenious follies", trans. Tobias G. Smollet, 1755; "shrewd lunacies", trans. John Ormsby, 1885). This mixture of cleverness and lack of moderation is considered by the author the interpretation's key of the work.

  17. Ballooning for Biologists: Mission Essentials for Flying Experiments on Large NASA Balloons

    Science.gov (United States)

    Smith, David J.; Sowa, Marianne

    2017-01-01

    Despite centuries of scientific balloon flights, only a handful of experiments have produced biologically-relevant results. Yet unlike orbital spaceflight, it is much faster and cheaper to conduct biology research with balloons, sending specimens to the near space environment of Earths stratosphere. Samples can be loaded the morning of a launch and sometimes returned to the laboratory within one day after flying. The National Aeronautics and Space Administration (NASA) flies large, unmanned scientific balloons from all over the globe, with missions ranging from hours to weeks in duration. A payload in the middle portion of the stratosphere (approx. 35 km above sea level) will be exposed to an environment similar to the surface of Mars: temperatures generally around -36 C, atmospheric pressure at a thin 1 kPa, relative humidity levels <1%, and a harsh illumination of ultraviolet (UV) and cosmic radiation levels (about 100 W/sq m and 0.1 mGy/d, respectively) that can be obtained nowhere else on the surface of the Earth, including environmental chambers and particle accelerator facilities attempting to simulate space radiation effects. Considering the operational advantages of ballooning and the fidelity of space-like stressors in the stratosphere, researchers in aerobiology, astrobiology, and space biology can benefit from balloon flight experiments as an intermediary step on the extraterrestrial continuum (ground, low Earth orbit, and deep space studies). Our presentation targets biologists with no background or experience in scientific ballooning. We will provide an overview of large balloon operations, biology topics that can be uniquely addressed in the stratosphere, and a roadmap for developing payloads to fly with NASA.

  18. Sleep and sleep disorders in Don Quixote.

    Science.gov (United States)

    Iranzo, Alex; Santamaria, Joan; de Riquer, Martín

    2004-01-01

    In Don Quijote de la Mancha, Miguel de Cervantes presents Don Quixote as an amazing character of the 17th century who suffers from delusions and illusions, believing himself to be a medieval knight errant. Besides this neuropsychiatric condition, Cervantes included masterful descriptions of several sleep disorders such as insomnia, sleep deprivation, disruptive loud snoring and rapid eye movement sleep behaviour disorder. In addition, he described the occurrence of physiological, vivid dreams and habitual, post-prandial sleepiness--the siesta. Cervantes' concept of sleep as a passive state where all cerebral activities are almost absent is in conflict with his description of abnormal behaviours during sleep and vivid, fantastic dreams. His concept of sleep was shared by his contemporary, Shakespeare, and could have been influenced by the reading of the classical Spanish book of psychiatry Examen de Ingenios (1575).

  19. Evaluating sources of job satisfaction: A survey of U.S. Fish and Wildlife refuge managers and biologists

    Science.gov (United States)

    Ponds, Phadrea D.; Brinson, Ayeisha A.; Benson, Delwin

    2003-01-01

    The following summary consists of revised excerpts from the thesis study that was conducted in 2000-2002 by Ayeisha Brinson, Colorado State University (Brinson, 2002). The purpose of this report is to provide the U.S. Fish and Wildlife Service (USFWS) with additional finding related to sources of job satisfaction. Because this is a report of additional findings from a length study, the information in this report is condensed and represented without references from the original research. The literature review, methodology, and discussion from the original thesis are not presented in this report. Any questions concerning the thesis should be directed to Ayeisha Brinson, who may be reached by e-mail. The purpose of the report is to examine differences and similarities between National Wildlife Refuge managers and biologists on a selection of independent variable related to job satisfaction occupation status (being either a manager or a biologist): are managers more satisfied with their jobs than biologist? If so, what are the components of that satisfaction? What are the sources of dissatisfaction? a?|

  20. An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins.

    Science.gov (United States)

    Ndossi, D G; Frizzell, C; Tremoen, N H; Fæste, C K; Verhaegen, S; Dahl, E; Eriksen, G S; Sørlie, M; Connolly, L; Ropstad, E

    2012-11-15

    Trichothecenes are a large family of chemically related mycotoxins. Deoxynivalenol (DON), T-2 and HT-2 toxins belong to this family and are produced by various species of Fusarium. The H295R steroidogenesis assay, regulation of steroidogenic gene expression and reporter gene assays (RGAs) for the detection of androgen, estrogen, progestagen and glucocorticoid (ant)agonist responses, have been used to assess the endocrine disrupting activity of DON, T-2 and HT-2 toxins. H295R cells were used as a model for steroidogenesis and gene expression studies and exposed with either DON (0.1-1000ng/ml), T-2 toxin (0.0005-5ng/ml) or HT-2 toxin (0.005-50ng/ml) for 48h. We observed a reduction in hormone levels in media of exposed cells following radioimmunoassay. Cell viability was determined by four colorimetric assays and we observed reduced cell viability with increasing toxin concentrations partly explaining the significant reduction in hormone levels at the highest toxin concentration of all three trichothecenes. Thirteen of the 16 steroidogenic genes analyzed by quantitative real time PCR (RT-qPCR) were significantly regulated (Pendocrine disruption, the present findings indicate that exposure to DON, T-2 toxin and HT-2 toxin have effects on cell viability, steroidogenesis and alteration in gene expression indicating their potential as endocrine disruptors. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  1. Don Quixote and the Peninsular War

    Directory of Open Access Journals (Sweden)

    Ceferino Caro López

    2009-12-01

    Full Text Available In 1808 some political writers appealed to the character of Don Quixote in order to write patriotic libels in which Napoleon was compared to the Knight from La Mancha. The analysis of those texts will show the ambiguity of the meaning of Cervantes’s creature, as it was sometimes thought to be a positive character, whereas in other occasions it was seen as the bearer of negative connotations. Thus criticism to Napoleon was built, according to different cases, on the identification or the opposition of the two figures.

  2. Don Pedro Laín Entralgo

    Directory of Open Access Journals (Sweden)

    Roberto Serpa Florez

    2001-08-01

    Full Text Available

    Al amanecer del martes 5 de junio murió don Pedro Laín Entralgo eminente médico, escritor, historiador de la medicina y académico, uno de las más grandes pensadores y humanistas españoles del siglo veinte (1908-2001. En España el trato de “don” es el de más alta categoría que puede darse: don Gregorio Marañón, don José Ortega y Gasset, don Miguel de Unamuno, don Carlos Jiménez Díaz, don Antonio Machado.

    Don Pedro Laín Entralgo fue uno de los más grandes historiadores de la medicina en todo el mundo:

    Miembro de la Real Academia de Medicina Española (desde 1948, Miembro de la Real Academia Española de la Lengua (desde 1954, Miembro de la Real Academia Española de Historia (desde 1962; por muchos años fue Presidente de la Real Academia de la Lengua y miembro numerario de la Academia de Medicina.

    Catedrático de Historia de la Medicina de la Universidad Central y Rector de ella hasta 1956, don Pedro Laín Entralgo dirigió y editó el más completo e importante tratado de Historia de la Medicina.

    En los siete volúmenes de La Historia Universal de la Medicina, publicados entre los años 1972 y 1975, colaboraron más de un centenar de autores de veinte países. Otros libros de los muchos que escribió:

    “España como problema” (1949, su manual de “Historia de la Medicina” (1978, “Historia de la Medicina Moderna y Contemporánea” (1963, “La relación médico-enfermo, historia y teoría” (1961, El que hacer del médico a lo largo de la historia de la cultura (el ars medica de los romanos, la thekné de los griegos y la técnica deshumanizada del siglo XX, la relación humana entre el médico y su paciente, las relaciones entre la praxis (el conocimiento y las destrezas y la ética y los valores, fueron objeto de sus meditaciones filosóficas.

    En el Epílogo de su libro La Medicina actual (1973 don Pedro Laín Entralgo escribió:

    “La fabulosa medicina actual es, en

  3. Transgender people in the military: don't ask? Don't tell? Don't enlist!

    Science.gov (United States)

    Yerke, Adam F; Mitchell, Valory

    2013-01-01

    The repeal of Don't Ask, Don't Tell offered legal equality to sexual minorities in the military. However, this big step forward had no impact on the policy of exclusion and rejection and the fear and secrecy that resulted for transgender people (whether lesbian, gay, bisexual, or heterosexual). In this article, we argue that transgender citizens should have equal opportunity to honorably serve their country, and to be treated with respect and sensitivity as they do so. Many transgender persons may be drawn to military service and its ethos of masculine values. However, they are currently not permitted entry, and, if they are to enter, must remain hidden or face dismissal, leaving them vulnerable to harassment. While they report both positive and negative experiences during their service, research documents discrimination in veterans' healthcare as well as mental health risks resulting from fear and harassment. In contrast to the United States, 11 countries include transgender people in their militaries. Drawing in part from their examples, we end with recommendations for change in the direction of respect and equality of opportunity.

  4. Reading "Las Meninas": An Ekphrastic Approach to Teaching "Don Quijote"

    Science.gov (United States)

    Ortuno, Marian

    2012-01-01

    Reading and teaching "Don Quijote" present multiple challenges to twenty-first century students and instructors who are culturally and historically distanced from the seventeenth century. With "Las Meninas" serving as a visual lexicon for cuing correlative themes and events in "Don Quijote", the instructor, through an ekphrastic, interdisciplinary…

  5. Fungal flora and deoxynivalenol (DON) level in wheat from Jeddah ...

    African Journals Online (AJOL)

    This study aimed to explore the fungal flora along with the DON concentration in the collected wheat samples from Jeddah market to correlate between this flora and the detected DON. Whole grain wheat samples were collected from Jeddah market and this represents imported and locally produced wheat. The results ...

  6. Cometary Activity in Near-Earth Asteroid Don Quixote

    NARCIS (Netherlands)

    Mommert, M.; Hora, J. L.; Harris, A. W.; Reach, W. T.; Mueller, M.; Thomas, C. A.; Emery, J. P.; Trilling, D. E.; Delbo', M.; Smith, H.

    2013-01-01

    The near-Earth object (NEO) population is thought to comprise a number of "dormant" short-period comets [1]. One of the most promising NEO candidates for a cometary origin is (3552) Don Quixote, due to its comet-like orbit and albedo. We present the discovery of cometary activity in (3552) Don

  7. Quantum Physics for Scientists and Technologists Fundamental Principles and Applications for Biologists, Chemists, Computer Scientists, and Nanotechnologists

    CERN Document Server

    Sanghera, Paul

    2011-01-01

    Presenting quantum physics for the non-physicists, Quantum Physics for Scientists and Technologists is a self-contained, cohesive, concise, yet comprehensive, story of quantum physics from the fields of science and technology, including computer science, biology, chemistry, and nanotechnology. The authors explain the concepts and phenomena in a practical fashion with only a minimum amount of math. Examples from, and references to, computer science, biology, chemistry, and nanotechnology throughout the book make the material accessible to biologists, chemists, computer scientists, and non-techn

  8. Don't be such a scientist talking substance in an age of style

    CERN Document Server

    Olson, Randy

    2009-01-01

    How to relate scientific information in a way that entertains and enlightens? After twenty years as a marine biologist, a Ph.D. from Harvard, a tenured professorship at the University of New Hampshire, and more than twenty published research papers, why is Dr. Randy Olson telling readers, 'Don't Be Such a Scientist'? The hard-earned advice comes from a fifteen-year career transition to filmmaking, culminating in the acclaimed documentaries "Flock of Dodos: The Evolution-Intelligent Design Circus" and "Sizzle: A Global Warming Comedy". In his first book, Olson makes clear what those glued to their microscopes and climate models may not recognize: the general public doesn't speak science. For better or worse, most of us rely not on intellect, but on what Olson terms the organs of mass communication: the heart, the gut, and even 'the lower organs'. Why else do some still question the existence of global warming or evolution when the evidence is irrefutable? Drawing on his own hilarious - and at times humiliating...

  9. Associação entre carcinoma espinocelular de cabeça e pescoço e polimorfismo no p53 (códon 72 P53 codon 72 polymorphism association with head and neck squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Zahra Mojtahedi

    2010-06-01

    Full Text Available O gene supressor tumoral p53 abriga um polimorfismo funcional que codifica ou arginina (Arg ou prolina (Pro no códon 72 da proteína p53. Este polimorfismo tem sido considerado associado com o desenvolvimento e prognóstico do carcinoma espinocelular de cabeça e pescoço (CECP. OBJETIVO: Foram avaliados genótipo e freqüências alélicas do códon 72 do p53 em pacientes iranianos com CECP. TIPO DE ESTUDO: Estudo de Caso. MATERIAIS E MÉTODOS: Um total de 132 pacientes com CECP e 123 controles saudáveis foram genotipados. A fonte de DNA foi composta de células mononucleares do sangue periférico. A amplificação do DNA foi realizada através da reação em cadeia da polimerase específica para alelos. RESULTADOS: A distribuição dos alelos e genótipos não foi significativamente diferente entre os pacientes e controles. Além disso, nenhuma associação estatisticamente significativa foi encontrada entre o polimorfismo do códon 72 do p53 e localização, sexo ou idade no momento do diagnóstico. No entanto, o genótipo Pro/Pro estava significativamente aumentado em pacientes no estágio IV (30,8% quando comparado ao estágio I-III da doença (11,1% (p=0,03, e um número significativamente maior de doentes com o alelo Pro teve um aumento no risco de desenvolver doença no estágio IV (OR=2,2, IC= 95% =1.2-4.2, p=0,01. CONCLUSÃO: Os dados revelaram que o polimorfismo do p53 não afeta o risco de CECP em iranianos; porém, pode afetar a progressão para um estágio superior tumor.p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg or proline (Pro in the protein p53 of codon 72. Such polymorphism has been associated with the development or prognosis of head and neck squamous cell carcinoma (HNSCC. AIM: we assessed codon 72 p53 allelic frequencies and genotypes in HNSCC Iranian patients. STUDY DESIGN: Case Study. MATERIALS AND METHODS: a total of 132 HNSCC patients and 123 healthy controls were

  10. Extraction of High Quality RNA from Cannabis sativa Bast Fibres: A Vademecum for Molecular Biologists

    Directory of Open Access Journals (Sweden)

    Gea Guerriero

    2016-07-01

    Full Text Available In plants there is no universal protocol for RNA extraction, since optimizations are required depending on the species, tissues and developmental stages. Some plants/tissues are rich in secondary metabolites or synthesize thick cell walls, which hinder an efficient RNA extraction. One such example is bast fibres, long extraxylary cells characterized by a thick cellulosic cell wall. Given the economic importance of bast fibres, which are used in the textile sector, as well as in biocomposites as green substitutes of glass fibres, it is desirable to better understand their development from a molecular point of view. This knowledge favours the development of biotechnological strategies aimed at improving specific properties of bast fibres. To be able to perform high-throughput analyses, such as, for instance, transcriptomics of bast fibres, RNA extraction is a crucial and limiting step. We here detail a protocol enabling the rapid extraction of high quality RNA from the bast fibres of textile hemp, Cannabis sativa L., a multi-purpose fibre crop standing in the spotlight of research.

  11. Bioavailability of dissolved organic nitrogen (DON) in wastewaters from animal feedlots and storage lagoons

    Science.gov (United States)

    Dissolved organic nitrogen (DON) transport from animal agriculture to surface waters can lead to eutrophication and dissolved oxygen depletion. Biodegradable DON (BDON) is a portion of DON that is mineralized by bacteria while bioavailable DON (ABDON) is utilized by bacteria and/or algae. This stu...

  12. Goober: A fully integrated and user-friendly microarray data management and analysis solution for core labs and bench biologists

    Directory of Open Access Journals (Sweden)

    Luo Wen

    2009-03-01

    Full Text Available Despite the large number of software tools developed to address different areas of microarray data analysis, very few offer an all-in-one solution with little learning curve. For microarray core labs, there are even fewer software packages available to help with their routine but critical tasks, such as data quality control (QC and inventory management. We have developed a simple-to-use web portal to allow bench biologists to analyze and query complicated microarray data and related biological pathways without prior training. Both experiment-based and gene-based analysis can be easily performed, even for the first-time user, through the intuitive multi-layer design and interactive graphic links. While being friendly to inexperienced users, most parameters in Goober can be easily adjusted via drop-down menus to allow advanced users to tailor their needs and perform more complicated analysis. Moreover, we have integrated graphic pathway analysis into the website to help users examine microarray data within the relevant biological content. Goober also contains features that cover most of the common tasks in microarray core labs, such as real time array QC, data loading, array usage and inventory tracking. Overall, Goober is a complete microarray solution to help biologists instantly discover valuable information from a microarray experiment and enhance the quality and productivity of microarray core labs. The whole package is freely available at http://sourceforge.net/projects/goober. A demo web server is available at http://www.goober-array.org.

  13. Neutrons for biologists: a beginner's guide, or why you should consider using neutrons

    Science.gov (United States)

    Lakey, Jeremy H.

    2009-01-01

    From the structures of isolated protein complexes to the molecular dynamics of whole cells, neutron methods can achieve a resolution in complex systems that is inaccessible to other techniques. Biology is fortunate in that it is rich in water and hydrogen, and this allows us to exploit the differential sensitivity of neutrons to this element and its major isotope, deuterium. Furthermore, neutrons exhibit wave properties that allow us to use them in similar ways to light, X-rays and electrons. This review aims to explain the basics of biological neutron science to encourage its greater use in solving difficult problems in the life sciences. PMID:19656821

  14. The President's pleasant surprise: how LGBT advocates ended Don't Ask, Don't Tell.

    Science.gov (United States)

    Frank, Nathaniel

    2013-01-01

    This study assesses the role of LGBT advocates in repealing the military's Don't Ask, Don't Tell policy in the U.S. Congress. It draws on the author's direct involvement with that effort as well as personal interviews and media evidence to consider the contributions of the Obama Administration, members of Congress, the media, and individuals and pressure groups in the repeal process. It argues that repeal succeeded not because of the effective implementation of a White House plan but because the pressure of LGBT advocates ultimately shattered several key obstacles including inadequate messaging and dysfunction and inertia among both politicians and interest groups in Washington. The article offers insight into the role of public pressure in forwarding social change.

  15. A biologist's view of the relevance of thermodynamics and physical chemistry to cryobiology.

    Science.gov (United States)

    Mazur, Peter

    2010-02-01

    Thermodynamics and physical chemistry have played powerful roles the past 45years in interpreting cryobiological problems and in predicting cryobiological outcomes. The author has been guided by a few core principles in using these concepts and tools and this paper discusses these core principles. They are (1) the importance of chemical potentials and of the difference between the chemical potentials of water and solutes inside the cell and outside in determining the direction and rate of fluxes of water and solutes. (2) The influence of the curvature of an ice crystal on its chemical potential and on the ability of ice to pass through pores in cell membranes, on the nucleation temperature of supercooled water, and on the recrystallization of ice. (3) The use of Le Chatalier's Principle in qualitatively predicting the direction of a reaction in response to variables like pressure. (4) The fact that the energy differences between State A and State B are independent of the path taken to go from A to B. (5) The importance of being aware of the assumptions underlying thermodynamic models of cryobiological events. And (6), the difficulties in obtaining experimental verification of thermodynamic and physical-chemical models. Copyright 2009 Elsevier Inc. All rights reserved.

  16. Reverse enGENEering of Regulatory Networks from Big Data: A Roadmap for Biologists

    Science.gov (United States)

    Dong, Xiaoxi; Yambartsev, Anatoly; Ramsey, Stephen A; Thomas, Lina D; Shulzhenko, Natalia; Morgun, Andrey

    2015-01-01

    Omics technologies enable unbiased investigation of biological systems through massively parallel sequence acquisition or molecular measurements, bringing the life sciences into the era of Big Data. A central challenge posed by such omics datasets is how to transform these data into biological knowledge, for example, how to use these data to answer questions such as: Which functional pathways are involved in cell differentiation? Which genes should we target to stop cancer? Network analysis is a powerful and general approach to solve this problem consisting of two fundamental stages, network reconstruction, and network interrogation. Here we provide an overview of network analysis including a step-by-step guide on how to perform and use this approach to investigate a biological question. In this guide, we also include the software packages that we and others employ for each of the steps of a network analysis workflow. PMID:25983554

  17. "Don Quijote" en el Reino Unido

    OpenAIRE

    Pardo García, Pedro Javier

    2013-01-01

    Preprint. El archivo es la maqueta de la entrada que aparecerá en el volumen XI de la "Gran Enciclopedia Cervantina" [ES] El texto recoge una visión panorámica de la recepción del "Quijote" en la literatura en lengua inglesa del Reino Unido a lo largo de cuatro siglos, desde 1605 a 2005. Tal recepción se divide en seis fases o períodos analizados en cada una de las seis partes de que consta el texto: 1) "Don Quijote" en el teatro: la visión cómica; 2) De la comedia a la sátira: la visión ...

  18. Don quijote, Christelike geloof en natuurwetenskap 1

    Directory of Open Access Journals (Sweden)

    H. P.P. Lötter

    1987-03-01

    Full Text Available The story about Don Qulchote and the windmills is used in this article as an analogy to typify the debates that have taken place in history between natural science and representatives of Christian religion. The analogy is tested on debates that took place around Galileo. Darwin, Newton, Cuvier and the Big Bang theory. The analogy matches these debates quite well and this Is explained by the view that scientific claims to knowledge, and claims to knowledge based on Christian faith, belong to different categories and are thus not concurrents for the same truth. Gilbert Ryle's criticism on Descartes' mind-body dualism is used here to strengthen this argument. The article is concluded by pointing out in what ways one can engage in a meaningful debate on the nature of the relationship between science and Christian religion.

  19. We don't need another hero.

    Science.gov (United States)

    Badaracco, J L

    2001-09-01

    Everybody loves the stories of heroes like Martin Luther King, Jr., Mother Teresa, and Gandhi. But the heroic model of moral leadership usually doesn't work in the corporate world. Modesty and restraint are largely responsible for the achievements of the most effective moral leaders in business. The author, a specialist in business ethics, says the quiet leaders he has studied follow four basic rules in meeting ethical challenges and making decisions. The rules constitute an important resource for executives who want to encourage the development of such leaders among their middle managers. The first rule is "Put things off till tomorrow." The passage of time allows turbulent waters to calm and lets leaders' moral instincts emerge. "Pick your battles" means that quiet leaders don't waste political capital on fights they can't win; they save it for occasions when they really want to fight. "Bend the rules, don't break them" sounds easier than it is--bending the rules in order to resolve a complicated situation requires imagination, discipline, restraint, flexibility, and entrepreneurship. The fourth rule, "Find a compromise," reflects the author's finding that quiet leaders try not to see situations as polarized tests of ethical principles. These individuals work hard to craft compromises that are "good enough"--responsible and workable enough--to satisfy themselves, their companies, and their customers. The vast majority of difficult problems are solved through the consistent striving of people working far from the limelight. Their quiet approach to leadership doesn't inspire, thrill, or provide story lines for uplifting TV shows. But the unglamorous efforts of quiet leaders make a tremendous difference every day in the corporate world.

  20. Empirical investigation of the ethical reasoning of physicians and molecular biologists – the importance of the four principles of biomedical ethics

    Science.gov (United States)

    Ebbesen, Mette; Pedersen, Birthe D

    2007-01-01

    Background This study presents an empirical investigation of the ethical reasoning and ethical issues at stake in the daily work of physicians and molecular biologists in Denmark. The aim of this study was to test empirically whether there is a difference in ethical considerations and principles between Danish physicians and Danish molecular biologists, and whether the bioethical principles of the American bioethicists Tom L. Beauchamp and James F. Childress are applicable to these groups. Method This study is based on 12 semi-structured interviews with three groups of respondents: a group of oncology physicians working in a clinic at a public hospital and two groups of molecular biologists conducting basic research, one group employed at a public university and the other in a private biopharmaceutical company. Results In this sample, the authors found that oncology physicians and molecular biologists employed in a private biopharmaceutical company have the specific principle of beneficence in mind in their daily work. Both groups are motivated to help sick patients. According to the study, molecular biologists explicitly consider nonmaleficence in relation to the environment, the researchers' own health, and animal models; and only implicitly in relation to patients or human subjects. In contrast, considerations of nonmaleficence by oncology physicians relate to patients or human subjects. Physicians and molecular biologists both consider the principle of respect for autonomy as a negative obligation in the sense that informed consent of patients should be respected. However, in contrast to molecular biologists, physicians experience the principle of respect for autonomy as a positive obligation as the physician, in dialogue with the patient, offers a medical prognosis based upon the patients wishes and ideas, mutual understanding, and respect. Finally, this study discloses utilitarian characteristics in the overall conception of justice as conceived by oncology

  1. Don Gallo: The Godfather of YA Short Stories.

    Science.gov (United States)

    Crowe, Chris

    1997-01-01

    Presents an interview with Don Gallo, editor of seven anthologies of short stories and one collection of plays, and author or editor of seven books about young adult fiction for teachers and scholars. (TB)

  2. Will 3552 Don Quixote escape from the Solar System?

    Directory of Open Access Journals (Sweden)

    Suryadi Siregar

    2011-05-01

    Full Text Available Asteroid 1983 SA, well known as 3552 Don Quixote, is one of Near Earth Asteroids (NEAs which is the most probable candidate for the cometary origin, or otherwise as Jupiter-Family-Comets (JFCs. The aim of this study is to investigate the possibility of 3552 Don Quixote to be ejected from the Solar System. This paper presents an orbital evolution of 100 hypothetical asteroids generated by cloning 3552 Don Quixote. Investigation of its orbital evolution is conducted by using the SWIFT subroutine package, where the gravitational perturbations of eight major planets in the Solar System are considered. Over very short time scales (220 kyr relative to the Solar System life time (10 Gyr, the asteroid 3552 Don Quixote gave an example of chaotic motion that can cause asteroid to move outward and may be followed by escaping from the Solar System. Probability of ejection within the 220 kyr time scale is 50%.

  3. Speak Up! But don't strain your voice

    Science.gov (United States)

    ... Disorders Speak Up! But don't strain your voice Past Issues / Fall 2008 Table of Contents For ... Javascript on. A clinical trial at the NIDCD Voice Center gave Sherdina Jones tools to limit voice ...

  4. Hyperbaric Oxygen Therapy: Don't Be Misled

    Science.gov (United States)

    ... Medical Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products For Consumers Home For Consumers Consumer Updates Hyperbaric Oxygen Therapy: Don't Be Misled Share Tweet Linkedin Pin ...

  5. Don’t Ask, Don’t Tell - Policy Analysis and Interpretation

    Science.gov (United States)

    1994-06-01

    biological or genetic factors, thereby disputing the idea that homosexuality is an aberrant behavior [Ref. 60]; the presence of " homophobia " in the...teachings. That’s a hard question because I’m not up on what other religions are saying.. .I’m a Roman Catholic.. .they say love your brother.. .but we...don’t like homosexuals. I guess we’re more tolerant than your southern baptists or southern christian religions . That was a good question I think. Q

  6. El libro "La locura de Don Quijote".

    Directory of Open Access Journals (Sweden)

    Efraim Otero Ruiz

    2007-09-01

    La Academia Colombiana, por su parte, se ha dedicado a recoger en preciosa compilación de gran formato los trabajos que los académicos de la lengua elaboraron y presentaron sobre el Ingenioso Hidalgo, cubriendo las diversas modalidades del personaje y su entorno, desde los aspectos médicos, económicos, sentimentales y legales pasando por la filología y la semántica hasta la flora, la ecología, la etnología y la filosofía de la Europa y la España de entonces. En esa recolección se incluyó lo que es hoy el capítulo sexto pero faltó, por razones de espacio y porque merecía sitial aparte, la totalidad de la erudita obra de Adolfo de Francisco Zea, sobre La Locura de Don Quijote, que nos ofrecen hoy en encomiable esfuerzo tripartita las Academias Nacionales de Medicina, de la Lengua y de Historia.

  7. Don Quijote, el escribidor y el escritor

    Directory of Open Access Journals (Sweden)

    Giovanna Pollarolo

    2010-06-01

    Full Text Available In his diverse critical studies, Mario Vargas Llosa has shown particular interest in reflecting on Miguel de Cervantes’s novelistic theory in accordance with his own concerns as a scholar and novelist. Suffice it to read the essay “Una novela para el siglo XXI” that he wrote in 2005 as an introduction to the edition of Don Quijote prepared to celebrate the IV Centenario, to make sure that Vargas Llosa “reads” Cervantes in accordance with his own reflections on the theory of the novel, fanaticism or the “insanity” of the characters, the fiction and its relationship with “reality”, the narrative voices or the problem of the narrator. But the Cervantes – Vargas Llosa relationship goes beyond the theoretical level or reflective and is manifested in his own novelistic creation such as ocurrs, specifically, in La tía Julia y el escribidor. In that sense, the main goal of this study is to analyze the “dialogue” that is set between La tía Julia y el escribidor and the Quijotefrom the point of view of the “insanity” of Pedro Camacho, the writer of radio soap operas created by Vargas Llosa, and their similarities with that of the knight-errant.

  8. Suicidal Thoughts in the Novel Don Quixote.

    Science.gov (United States)

    Pridmore, Saxby; Pridmore, Celeste

    2016-03-01

    During the last century suicide has been medicalised. This restrictive view has been challenged, and the wisdom of experts from beyond medicine is being valued. Fictional literature is a source of information regarding the human experience. To extend our understanding of suicide and suicidal thinking by examining the early-17th Century Spanish novel, "Don Quixote". Various translations were examined for accounts of suicide, suicidal thinking, and associated behaviour. There were no accounts of completed suicide. There was one statement indicating the belief that suicide could be triggered by mental disorder. There were five statements indicating that suicidal thinking could arise in situations of distress. Such distress arose from the actual/potential loss of a loved person, suffering by another person, and relentless sleep deprivation. There is one account of a person pretending to attempt suicide and achieving a self-inflicted wound, not with the intention to self-murder, but to impact the disposition of another person. The observation that in early-17th Century Spain suicide was acknowledged as means of dealing with distress is consistent with findings from other periods, and the present day. This strengthens the position that suicide can occur in the absence of mental disorder.

  9. Don Gonzalo Jimenez de Quesada. El Fundador

    Directory of Open Access Journals (Sweden)

    Alvaro López Pardo

    1989-09-01

    Full Text Available

    Discurso pronunciado por el Doctor Alvaro López Pardo Presidente de la Academia de Historia de Bogotá, al Consejo de Bogotá el día 6 de agosto de 1988. Sesión especial de los 450 años.

    Por el año de 1578, caminaba lentamente por las polvorientas calles del poblado de Mariquita, un anciano, casi octogenario, que mostraba en su piel huellas de un enfermedad que se decía era la de San Lázaro.

    Las gentes lo miraban pasar con una mezcla de respeto y de piedad. En su mirada, un tanto vaga, se podían apreciar destellos de la que fuera una recia personalidad. Esta pobre figura era nadie menos que el Mariscal Don Gonzalo Jiménez de Quesada.

    En esta población ardiente y lejana, cargado de deudas, sin techo propio, iba a morir el gran señor, el Gran Capitán, el Gran Aventurero que fundara ésta nuestra noble y muy leal Santa Fe de Bogotá, cuyos 450 años celebramos en este día.

    Parece increíble que en aquella época y con una agitada vida, Don Gonzalo hubiera llegado a tan avanzada edad, es muestra de la fuerza de una raza y del templo de su espíritu, que se sobreponía a todas las adversidades y contratiempos.

    ¿Qué recuerdos vendrían a la mente de este anciano cuando, sentado en una pobre silla de vaqueta, contempla el azul cielo del trópico? ¿Quizá su infancia en España, en Córdoba, donde naciera o en la imponente Granada de los moros, recuperada hacía unos años por la Reina Isabel. Viendo los jardines de la Alhambra, el Generalife y al fondo el blanco perpetuo de la Sierra Nevada. O vendría a su mente el paso del fúnebre cortejo de Felipe el Hermoso y su lunática viuda Doña Juana?

    Sería tal vez el periodo de su juventud, oyendo las aventuras de Cortés en la Conquista de México, en medio de una Europa convulsionada y con España como centro de la misma. O quizás cuando estudiaba leyes en Salamanca y se metía en pleitos que no siempre ganaba y como

  10. [Spanish neuroscience in times of Don Quixote].

    Science.gov (United States)

    Martín-Araguz, Antonio; Mikola, Yvett; Almendral-Doncel, Raquel; Campos-Bueno, Javier

    2016-02-16

    Miguel de Cervantes Saavedra published his immortal work Don Quixote of La Mancha in a time of crisis and decadence in Spain that occurred during the transition between the 16th and 17th centuries. In 2016 we commemorate the fourth centenary of the death of our distinguished man of letters, and thus in this article we analyse the status of Hispanic neuroscience, both in the Quixote itself and in other works by the most significant contemporary writers of that time. Despite the adverse historical circumstances, the shift from the Renaissance to the Baroque periods, in the Crown of Castile, was a flourishing period for literature (Spanish Golden Age) and other Hispanic arts (painting, sculpture, architecture and music), as well as bearing witness to a prodigious creativity in the field of neuroscience, including the field of natural philosophy. In his book Antoniana Margarita the physician Gomez Pereira laid the foundations for brain mechanism and the concept of conditioned reflexes several decades ahead of his time. The apothecary Miguel Sabuco also anticipated the concept of neurotransmission centuries ahead of his time in his New Philosophy. The physician Juan Huarte de San Juan was the founder of neuropsychology and experimental psychology, and his Examination of Men's Wits has been one of the most influential and widely translated scientific texts of all times. Its concepts are clearly reflected in Cervantes' Quixote. This analysis of Cervantes' work within the cultural setting of the book is intended as a homage to the immortal figure of our 'Prince of Wits' in the fourth centenary of his death.

  11. Viajando con Don Quijote en el siglo XXI

    Directory of Open Access Journals (Sweden)

    Odilíe Rojas-López

    2006-06-01

    Full Text Available Don Quixote has ridden with us for a long time now, and as if his fight against windmills were not enough, Don Quixote still has many more difficult situations to combat in the present times. Will the Knight of the Sad Figure accomplish this new deed? It is our challenge to find an answer to this inquiry. For this purpose, the author of this essay inserts the Knight of the Sad Figure in XXI century society. The author transforms the values, costumes and points of view of the times of the literary piece and establishes a series of relationships between the literary text, the main character and several current daily life situations. Don Quixote will certainly continue his fight against all the conditions we encounter nowadays. There is no doubt, then, that this knight still lives among us.

  12. Dostoyevski and Don Quijote: Poetics and Aesthetics of a Delusion

    Directory of Open Access Journals (Sweden)

    Tamara Djermanovic

    2015-12-01

    Full Text Available In Fedor Mikhailovich Dostoevsky’s body of work (1821-1881 one can find more than thirty references to Don Quixote; while some of them allude to the novel of Don Quixote itself, other ones refer to Cervantes’ hero as an archetypal figure. Since decades ago, the Russian literary criticism has been interested in the Russian quixotism – including Dostoevsky’s work – and important studies on this subject have been published recently. This study follows Dostoevsky’s references on La Mancha’s Knight as an independent figure of Cervantes’ novel, and the different symbolism Don Quixote’s figure has had in both Russian people and Russian intelligentsia.

  13. Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells

    International Nuclear Information System (INIS)

    Bensassi, Fatma; El Golli-Bennour, Emna; Abid-Essefi, Salwa; Bouaziz, Chayma; Hajlaoui, Mohamed Rabeh; Bacha, Hassen

    2009-01-01

    The mycotoxin, deoxynivalenol (DON), is generally detected in cereal grains and grain-based food products worldwide. Therefore, DON has numerous toxicological effects on animals and humans. The present investigation was conducted to determine the molecular aspects of DON toxicity on human colon carcinoma cells (HT 29). To this aim, we have monitored the effects of DON on (i) cell viability, (ii) Heat shock protein expressions as a parameter of protective and adaptive response, (iii) oxidative damage and (iv) cell death signalling pathway. Our results clearly showed that DON treatment inhibits cell proliferation, did not induce Hsp 70 protein expression and reactive oxygen species generation. We have also demonstrated that this toxin induced a DNA fragmentation followed by p53 and caspase-3 activations. Finally, our findings suggested that oxidative damage is not the major contributor to DON toxicity. This mycotoxin induces direct DNA lesions and could be considered by this fact as a genotoxic agent inducing cell death via an apoptotic process.

  14. Biologists Bridging Science and the Conservation Movement : The Rise of Nature Conservation and Nature Management in the Netherlands, 1850-1950

    NARCIS (Netherlands)

    van der Windt, Henny J.

    This paper investigates the importance and various roles of amateur naturalists and biologists in the conservation movement between 1850 and 1950, in particular in the Netherlands. It is concluded that biological sciences were important resources for Dutch nature conservation, although the extent of

  15. Science and Fiction. On Don Quijote’s Epistemological Skepticism

    Directory of Open Access Journals (Sweden)

    Félix Schmelzer

    2016-11-01

    Full Text Available The present work seeks to analyze the representation of scientific knowledge in Cervantes’ Quixote, focusing on various passages that underline the scientific expertise of don Quixote himself. It is shown that the novel contains a subtle critique of science, based on an epistemological skepticism with regard to the arbitrariness of our world concepts. The characterization of don Quixote as a man of science even permits deducting that he suffers from a ‘double mental damage’, caused by the lecture of both books of cavalry and science. Cervantes thus would consider science to be fiction, a very modern point of view.

  16. Don Juan de Palafox y Mendoza, obispo–poeta

    OpenAIRE

    Mata-Induráin, C. (Carlos)

    2000-01-01

    La rica personalidad de don Juan de Palafox y Mendoza (Baños de Fitero, Navarra, 1600 – Burgo de Osma, Soria, 1659) hace posible el acercamiento a su figura desde muy distintas perspectivas. Una de ellas, y de las menos estudiadas, es su faceta de hombre de letras. -------------------------- The rich character of Don Juan de Palafox y Mendoza (Fitero, 1600 - Burgo de Osma, Soria, 1659) makes possible the approach to the figure from different perspectives. One of them, and least studied, is hi...

  17. Fuel elements assembling for the DON project exponential experience

    International Nuclear Information System (INIS)

    Anca Abati, R. de

    1966-01-01

    It is described the fuel unit used in the DON exponential experience, the manufacturing installments and tools as well as the stages in the fabrication.These 74 elements contain each 19 cartridges loaded with synterized urania, uranium carbide and indium, gold, and manganese probes. They were arranged in calandria-like tubes and the process-tube. This last one containing a cooling liquid simulating the reactor organic. Besides being used in the DON reactor exponential experience they were used in critic essays by the substitution method in the French reactor AQUILON II. (Author) 6 refs

  18. Pia Petersen sous le signe de don Quichotte

    Directory of Open Access Journals (Sweden)

    Esther Bautista Naranjo

    2013-04-01

    Full Text Available This interview has been motivated by the Cervantean intertextuality of Pia Petersen’s (a French-speaking Danish author last novel, Le Chien de don Quichotte (2012. Departing from the values that the writer attributes to Cervantes’ work, I try to establish a connection with a specific critical trend in order to test, later on, to which extent this approach is used by the author to create a series of characters placed under the sign of don Quixote. Finally, I evaluate her novel’s relation with contemporary reality.

  19. Don Quixote's countenance before and after losing his teeth.

    Science.gov (United States)

    del Valle, A; Romero, M

    2009-02-01

    The authors of this paper wish to draw attention to certain not-so-well-known aspects concerning the epithet "Knight of the Woeful Countenance", by which Cervantes' character Don Quixote is universally known. Cervantes used it to highlight the loss of his hero's molars and incisors; thus, the reduced vertical dimension of his face, along with his sagging cheeks and deepened facial furrows, was the reason for his permanently sorrowful countenance. Luis Martínez, a professional illustrator following instructions from the authors of this paper, has recreated the face of Don Quixote as Miguel de Cervantes may well have imagined it for his celebrated character.

  20. Det litterære rum i Don Quixote

    DEFF Research Database (Denmark)

    Brink, Dennis Meyhoff

    2003-01-01

    Don Quixote kommer til verden i det måske mest afgørende øjeblik i den vestlige rumopfattelses historie - nemlig i det øjeblik, hvor forestillingen om, at vi lever i et uendeligt univers, erstatter den gammeleuropæiske forestilling om verdensrummet som et endeligt kosmos. Det nye verdensrum danner...... for første gang baggrunden for konstruktionen af et litterært rum i Don Quixote, og er på denne måde med til at skabe en ny litterær form: Romanen....

  1. Cometary Activity in Near-Earth Asteroid (3552) Don Quixote

    Science.gov (United States)

    Mommert, M.; Hora, J. L.; Harris, A. W.; Reach, W. T.; Mueller, M.; Thomas, C. A.; Emery, J. P.; Trilling, D. E.; Delbo', M.; Smith, H.

    2013-09-01

    The near-Earth object (NEO) population is thought to comprise a number of "dormant" short-period comets [1]. One of the most promising NEO candidates for a cometary origin is (3552) Don Quixote, due to its comet-like orbit and albedo. We present the discovery of cometary activity in (3552) Don Quixote based on thermal-infrared obser- vations made with the Spitzer Space Telescope. Our observations clearly show the presence of a coma and a tail which we identify as molecular line emission from CO2 and thermal emission from dust. Our discovery indicates that more NEOs may harbor volatiles than previously expected.

  2. [New insights in the treatment of chronic lymphocytic leukemia and role of the biologist in the monitoring of the treatments].

    Science.gov (United States)

    Troussard, Xavier; Cornet, Édouard

    2016-01-01

    Chronic lymphocytic leukemia (CLL) is the most common hematologic malignancy in France. Much progress has been made in recent years in understanding the pathophysiology of the disease, the definition of diagnostic criteria (>5 G/L of clonal B-lymphocytes), identification of prognostic criteria, including a better understanding of fragile patients, high risk patients and even more recently by the emergence of new highly effective drugs, doing discuss their place in the wide therapeutic panel we have. The treatment of patients with CLL is indicated in patients with progressive stage A, stage B or stage C. The new drugs currently available include not only the new generation of anti-CD20 monoclonal antibodies, type I (ofatumumab) or type II (obinutuzumab), Bcl-2 inhibitors (GDC-0199/ABT-199) and now the new small molecules available orally, including Bruton tyrosine kinase inhibitor (BTK) and phosphor-inositide 3-kinase (PI3K) inhibitor. The role of the biologist in monitoring a patient treated for CLL is essential, the latter to make the diagnosis of CLL, the search for prognostic factors (Binet stage, lymphocyte doubling time, looking for a 17p deletion or TP53 mutations, study of mutational profile of heavy chain genes of immunoglobulins IGHV) and biological monitoring of the different treatments. We will study in this paper the results obtained with these drugs, insisting today more than ever on the need to set up a clinical and biological complementarity to allow optimal medical management of patients with CLL. The mechanisms of actions are discussed, as well as the response criteria we should use to evaluate the effectiveness of these treatments in clinical practice.

  3. Don Favareau and the Road to Biosemiotic Transdisciplinarity

    DEFF Research Database (Denmark)

    Brier, Søren

    2017-01-01

    Don Favareau has been a dynamic contributor to the development of biosemiotics its organization, not only with his seminal book: Essential Readings in Biosemiotic: Anthology and Commentary from 2010, where he edited all his colleagues’ writings creating the history of biosemiotics. He has assumed...

  4. Don Juan Huarte de San Juan: El doctor que anticipó la melancolía de Don Quijote Don Juan Huarte de San Juan: The doctor who antocipated Don Quixote´s Melancholy

    Directory of Open Access Journals (Sweden)

    Pedro García Martín

    2009-03-01

    Full Text Available El estado de enajenación del ingenioso hidalgo don Quijote lo había aprendido Cervantes a través del doctor Juan Huarte San Juan, autor del famoso ensayo Examen de ingenios, donde formula la teoría de los humores para explicar el cuerpo y el carácter del hombre. En este artículo, pues, repasaremos la biografía de este personaje, analizaremos la formación de los médicos en las universidades de la España del Siglo de Oro, la influencia del Examen en la Europa de su tiempo y en la obra cervantina a través de la melancolía de don Quijote y de la locura del Licenciado Vidriera. Para terminar con la aplicación literaria de las tesis sobre ingenios que definiera nuestro dilecto médico de resonancia mundial.Cervantes learned about Don Quixote's derangement through Juan Huarte de San Juan's famous treatise Examen de ingenios, where he deployed the humoral theory to explain human body and character. In this article Huarte's biography will be summarized, analyzing the academic background of golden age Spanish doctors, and the impact of Examen in Early Modern Europe and in Cervante's work by examining Don Quixote's melancholy and Licenciado Vidriera's madness. Finally, I will show how the internationally famous Spanish doctor's thesis was used in literature.

  5. "Don Kihotõ" nazõvajut lutshshih / Boris Tuch

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2003-01-01

    Lõppenud festivali FIPRESCI auhinna sai türgi film "Kauge" ("Uzak") : režissöör Nuri Bilge Ceylan. Rahvusvaheline filmiklubide föderatsioon (FICC) andis oma auhinna Don Quijote Andrei Zvjagintsevi filmile "Tagasitulek" ("Vozvrashtshenije") ja eriauhinna hiinlase Chen Kaige filmile "Üheskoos" ("Han ni zai ylki")

  6. Fjodor Bondartshuk dodelal "Tihhi Don" ottsa / Olga Saburova

    Index Scriptorium Estoniae

    Saburova, Olga

    2006-01-01

    Fjodor Bondartshuk monteeris kokku tema isa Sergei poolt Itaalias 13 aastat tagasi pooleli jäänud Mihhail Sholohhovi romaani järgi tehtud teleseriaali "Vaikne Don", mida hakkab Venemaa televisiooni 1. Kanal näitama 7. novembril

  7. "Tihhi Don" : Fjodor Bondartshuk zakontshil film svojego otsa / Darja Zavgorodnjaja

    Index Scriptorium Estoniae

    Zavgorodnjaja, Darja

    2006-01-01

    Fjodor Bondartshuk monteeris kokku tema isa Sergei poolt Itaalias 13 aastat tagasi pooleli jäänud Mihhail Sholohhovi romaani järgi tehtud teleseriaali "Vaikne Don", mida hakkab Venemaa televisiooni 1. Kanal näitama 7. novembril

  8. Saying “Yes” to the Human Condition: Don Maclennan's ...

    African Journals Online (AJOL)

    This essay seeks to establish a connection between the poet Don Maclennan's views on death and on the meaning of life. Specifically, after exploring the various attitudes that Maclennan adopts towards death, an argument is made that – owing to Maclennan's views on the meaning of life – neither one of these attitudes is ...

  9. Don Quixote og romangenren

    DEFF Research Database (Denmark)

    Kluge, Sofie

    Quixote and the Novel deals with the reception of Cervantes' masterpiece in literary criticism, examining Don Quixote's significance for novelistic theory from the 17th century through today. As such, the book is an introduction to the literary history of this seminal modern genre. Demonstrating...

  10. The Lessons of Don Quixote as Viewed from the Classroom.

    Science.gov (United States)

    Perrin, Paulette

    2001-01-01

    Comparing teachers to Don Quixote, the author describes how the profession is caught between modernism and postmodernism. She offers action research and collegiality as ways to break the bounds of the entrenched, hierarchical system of education and its associated cultural values. (SK)

  11. Don Quixote --- a possible parent body of a meteor shower

    Science.gov (United States)

    Rudawska, R.; Vaubaillon, J.

    2014-07-01

    This talk addresses the topic of meteoroid stream parent body in relation to meteor showers observed on the Earth. We carry out a further search to investigate the possibility of meteor shower observations caused by particles ejected from (3552) Don Quixote. The (3552) Don Quixote asteroid was discovered in 1983 as an Amor asteroid. The Tisserand parameter for the orbit has a value of 2.315 with respect to Jupiter, which indicates a comet-like orbit. The diameter of the object calculated from the absolute magnitude, is in the range of 12.3--24.5 km. It all makes Don Quixote a good candidate for a short-period comet among known near-Earth objects, which the recently observed cometary activity confirms [1]. We have investigated the orbital evolution of the meteoroid stream originated from Don Quixote. If the object was active in the past, it might be a parent body for a meteor shower observed on the Earth. The model for the generation and evolution of the meteoroid stream in the Solar System is taken from [2]. The asteroid's orbital elements and physical properties are taken from the JPL horizons website. The ejections of meteoroids from the asteroid surface took place when the asteroid was passing its perihelion between 5000 B.C. and 2013 A.D. Next, the orbits of ejected meteoroids were integrated to the year 2050. If a meteoroid is sufficiently close to the Earth, its orbital parameters are saved and compared with known showers.

  12. IDEA: An Interdisciplinary Unit Comparing "Don Quixote" to "Hamlet."

    Science.gov (United States)

    Harris, Mary J. G.

    2001-01-01

    Describes an idea for teaching language through content-based instruction in which a high school Spanish class studying a shortened abridged version of Cervantes'"Don Quixote" and an English class reading Shakespeare's "Hamlet," did a simple comparative analysis of the two texts. (Author/VWL)

  13. Experiments in rooting bishop pine (Pinus muricata D. Don) cuttings

    Science.gov (United States)

    Constance I. Millar

    1987-01-01

    Presented here are results of rooting studies using hedges established from juvenile seedlings of "blue" and "green" foliaged bishop pine (Pinus muricata D. Don) from Mendocino and Sonoma Counties, California. Rootability, averaged over all clones and all setting dates, was 88%. The average time for 50% of the...

  14. Workshop on trichothecenes with a focus on DON: summary report

    DEFF Research Database (Denmark)

    Larsen, John Christian; Hunt, Josephine; Perrin, Irene

    2004-01-01

    Natural Toxin Task Force therefore organised a workshop on trichothecenes with a special focus on deoxynivalenol (DON). A number of experts reviewed the current knowledge on trichothecenes with respect to occurrence, including aspects of mould growth, toxin formation, storage and effects of processing...

  15. The Comprehensive Review Working Group and Don't Ask, Don't Tell repeal at the Department of Defense.

    Science.gov (United States)

    Lee, Jonathan L

    2013-01-01

    In February 2010, Secretary of Defense Robert Gates and Chairman of the Joint Chiefs of Staff Adm. Michael Mullen established the Comprehensive Review Working Group (CRWG) to conduct a comprehensive review of the issues associated with a repeal of Don't Ask, Don't Tell (DADT). Over the next 10 months, the CRWG undertook one of the most extensive studies of a personnel issue in the history of the U.S. military. This article describes the work and the findings of the CRWG (on which the author served) in the context of the activities within the Department of Defense (DoD) following President Obama's call for DADT repeal in his January 2010 State of the Union Address and leading up to the passage of the Don't Ask, Don't Tell Repeal Act in December 2010. It argues that the CRWG served a number of important functions in the DADT repeal process, particularly that it a) provided a rigorous, fact-based assessment of the impacts of repeal from which DoD senior leaders and Congress could base their views; b) developed a road map for a smooth and orderly implementation of repeal; and c) opened a conversation among military service members about what repeal would really mean to them. In doing so, the CRWG contributed to what has been a largely incident-free and successful transition to a post-DADT military.

  16. Weathering and Salt Accumulation at Don Juan and Don Qiuxote Ponds in the Anatarctic Dry Valleys as an Analogue for Alteration at Mars

    Science.gov (United States)

    Englert, P.; Bishop, J. L.; Sutter, B.; Gibson, E. K.; Koeberl, K.

    2017-07-01

    Increased abundances of soluble cations and anions were observed in sediments a few cm below the surface at Don Juan and Don Quixote Pond. This is attributed to increased chemical activity just below the surface and represents an analogue for Mars.

  17. CDC Vital Signs–Blood Pressure Medicines Don’t Work If People Don’t Take Them

    Centers for Disease Control (CDC) Podcasts

    2016-09-13

    Blood pressure medicines don’t work if people don’t take them. Learn how health care systems can work with patients to make taking medicines easier.  Created: 9/13/2016 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 9/13/2016.

  18. Cellular modelling of secondary radial growth in conifer trees: application to Pinus radiata (D. Don).

    Science.gov (United States)

    Forest, Loïc; Demongeot, Jacques; Demongeota, Jacques

    2006-05-01

    The radial growth of conifer trees proceeds from the dynamics of a merismatic tissue called vascular cambium or cambium. Cambium is a thin layer of active proliferating cells. The purpose of this paper was to model the main characteristics of cambial activity and its consecutive radial growth. Cell growth is under the control of the auxin hormone indole-3-acetic. The model is composed of a discrete part, which accounts for cellular proliferation, and a continuous part involving the transport of auxin. Cambium is modeled in a two-dimensional cross-section by a cellular automaton that describes the set of all its constitutive cells. Proliferation is defined as growth and division of cambial cells under neighbouring constraints, which can eliminate some cells from the cambium. The cell-growth rate is determined from auxin concentration, calculated with the continuous model. We studied the integration of each elementary cambial cell activity into the global coherent movement of macroscopic morphogenesis. Cases of normal and abnormal growth of Pinus radiata (D. Don) are modelled. Abnormal growth includes deformed trees where gravity influences auxin transport, producing heterogeneous radial growth. Cross-sectional microscopic views are also provided to validate the model's hypothesis and results.

  19. Advances in stem cells and regenerative medicine: single-cell dynamics, new models and translational perspectives.

    Science.gov (United States)

    Twigger, Alecia-Jane; Scheel, Christina H

    2017-09-01

    An international cohort of over 300 stem cell biologists came together in Heidelberg, Germany in May 2017 as delegates of the 'Advances in Stem Cells and Regenerative Medicine' conference run through the European Molecular Biology Organization. This Meeting Review highlights the novel insights into stem cell regulation, new technologies aiding in discovery and exciting breakthroughs in the field of regenerative medicine that emerged from the meeting. © 2017. Published by The Company of Biologists Ltd.

  20. Evaluation of deoxynivalenol-induced toxic effects on DF-1 cells in vitro: cell-cycle arrest, oxidative stress, and apoptosis.

    Science.gov (United States)

    Li, Daotong; Ye, Yaqiong; Lin, Shaoqing; Deng, Li; Fan, Xiaolong; Zhang, Yuan; Deng, Xianbo; Li, Yugu; Yan, Haikuo; Ma, Yongjiang

    2014-01-01

    Deoxynivalenol (DON) is one of the most common mycotoxin contaminants of raw and processed cereal food. Lymphoid cells and fibroblasts are specified to be the most DON-sensitive cell types. In this study, we investigated the toxic effects of DON in chicken embryo fibroblast DF-1 cells. The results showed that DON significantly inhibited DF-1 cell viability in both a time- and concentration-dependent manner. DON could also inhibit the proliferation of DF-1 cells through G2/M phase arrest in the cell cycle progression. Moreover, oxidative stress induced by DON was indicated by increased levels of reactive oxygen species (ROS), malondialdehyde (MDA), and decreased levels of glutathione (GSH) and superoxide dismutase (SOD). In addition, DON could also cause mitochondrial damage by decreasing the mitochondrial membrane potential and induce apoptosis accompanied with the up-regulation of apoptosis-related genes including Caspase-3, Caspase-8, Caspase-9, and AIFM1. These results suggested that DON could cause cell cycle arrest, oxidative stress, and apoptosis in DF-1 cells. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Don Carlos: Variations of Tragic from Schiller to Verdi

    Directory of Open Access Journals (Sweden)

    Fabio Vittorini

    2017-11-01

    Full Text Available In 1867 Giuseppe Verdi makes a grand opéra out of the dramatic poem Don Carlos, Infant von Spanien (1787 by Friedrich von Schiller. The workshop of Don Carlos lasts twenty years, from 1866 to 1886, when Verdi (reopens and closes several other workshops (Simon Boccanegra, La forza del destino, Aida, Requiem, Otello, creating a porous work in progress, whose analysis keeps giving us surprises. The libretto by Joseph Méry et Camille Du Locle, under the supervision of the composer, is a palimpsest where, under the official text referable to the common historical nucleus and its best known literary versions, some hidden or deleted heterogeneous texts appear, in a supranational, multilinguistic, intercultural and intertextual dimension, not always stirring along the road of a locatable derivation, of a voluntary imitation, but sometimes taking the shape of an unpredictable dissemination.

  2. Don Quixote an Celia: the desire to live other lives

    Directory of Open Access Journals (Sweden)

    María Jesús Fraga Fernández-Cuevas

    2012-12-01

    Full Text Available The present study explores the parallelisms between Don Quixote and Elena Fortun’s novels Celia. First, it enumerates the various activities that prove the author’s interest in Cervantes and his work, as well as the possible intervention of her mentor, Maria Martinez Sierra, in the genesis of the child’s character. Both novels, of dialogical nature, share an episodic structure articulated by a weak storyline. Its protagonists are animated by the desire to live the lives of the characters of their favorite readings. They confuse fantasy and reality causing situations whose results are almost always adverse. If Don Quixote dies back to the reason, so will Celia, the girl, with her entry into adulthood by resigning her fantasies, which will be taken up by new generations of children.

  3. To the Spanish Young People: Don Quixote Dreyfussard

    Directory of Open Access Journals (Sweden)

    Virginia Ramírez Martín

    2013-12-01

    Full Text Available In 1898, Spanish press take up part of its pages with a relevant international issue: the Dreyfus affair. The case was widely covered by Spanish newspapers, in special by Don Quijote, a Madrilenian satiric press, whose Director promoted a campaign in favour of Zola collecting signatures in order to the French litterateur was aware that Spain was close to him. This initiative is completed with a call to Spanish young people who is illustrated with a quixotic caricature. Cervantine character personifies the idea of justice getting to transmit during the Spanish crisis at the end of the nineteenth century the image of the nobleman forged by Spanish stereotypical, like a crusader fighting for a noble cause, thus turning Don Quixote into another dreyfussard.

  4. Why don?t humanitarian organizations provide safe abortion services?

    OpenAIRE

    McGinn, Therese; Casey, Sara E.

    2016-01-01

    Background Although sexual and reproductive health services have become more available in humanitarian settings over the last decade, safe abortion services are still rarely provided. The authors? observations suggest that four reasons are typically given for this gap: ?There?s no need?; ?Abortion is too complicated to provide in crises?; ?Donors don?t fund abortion services?; and ?Abortion is illegal?. Discussion However, each of these reasons is based on false premises. Unsafe abortion is a...

  5. Don Quijote in Nineteenth-Century English Theatre

    Directory of Open Access Journals (Sweden)

    J. A. Garrido Ardila

    2014-12-01

    Full Text Available This article brings to light a group of Cervantine English literary works hitherto unknown to present-day Cervantes studies: seven theatrical adaptations of Don Quixote (two anonymous ones in addition to those by Charles Dibdin, Joseph Moser, G. A. Macfarren, C. A. Maltby and P. Milton, a comedy with a Quixotic title (by George Dance, and five Quixotic fictions (two anonymous, in addition to those by Lily Spender, Maurice Hewlett and A. T. Quiller-Couch. Three of these plays, had been noted by Leopoldo Rius in 1899 (Moser, Macfarren, Maltby; the other four are presented for the first time here. In order to chart a fuller and more complete history of Don Quixote on the English stage, this article provides relevant information on those seven plays. An examination of these works reinforces the previous theses that underscore the essentially comical nature of Quixotic plays in nineteenth-century England, a fact of relevance in the study of the English reception of Don Quixote in the course of that century.

  6. Multiple sclerosis presenting with erotomanic delusions in the context of "Don't ask, don't tell".

    Science.gov (United States)

    Smith, Earl Justice

    2009-03-01

    A female patient presented with erotomanic delusions of other female soldiers sexually harassing her and plotting to sexually assault her. On MRI, the patient was found to have numerous periventricular foci of signal changes extending into the deep white matter of both hemispheres. The MRI findings, along with lumbar puncture findings of oligoclonal bands in the cerebral spinal fluid, were consistent with a diagnosis of multiple sclerosis. After treatment with aripiprazole acutely and interferon beta-1a for several months, the patient experienced a decrease in her psychosis. The discussion of this case includes a brief overview of psychosis as a presenting symptom of multiple sclerosis, and also includes consideration of the patient's initial reluctance to seek treatment in light of the policy known colloquially as "don't ask, don't tell".

  7. Lesbian, Gay, Bisexual, and Transgender (LGBT) Service Members: Life After Don't Ask, Don't Tell.

    Science.gov (United States)

    Goldbach, Jeremy T; Castro, Carl Andrew

    2016-06-01

    Lesbian, gay, and bisexual service members can serve openly in the military with the repeal of the Don't Ask, Don't Tell policy. The fate of transgender service members remains uncertain as the policy preventing them from serving in the military remains under review. The health care needs of these populations remain for the most part unknown, with total acceptance and integration in the military yet to be achieved. In this paper, we review the literature on the health care needs of lesbian, gay, bisexual, and transgender (LGBT) service members, relying heavily on what is known about LGBT civilian and veteran populations. Significant research gaps about the health care needs of LGBT service members are identified, along with recommendations for closing those gaps. In addition, recommendations for improving LGBT acceptance and integration within the military are provided.

  8. The myth of the warrior: martial masculinity and the end of Don't Ask, Don't Tell.

    Science.gov (United States)

    Allsep, L Michael

    2013-01-01

    The image of the male warrior still dominates military culture, to the exclusion of women and homosexuals. Complicating the picture is a technological revolution that promises to widen the current gap between the myth and reality of the modern warrior even further. Nonetheless, despite long arguing that homosexuals were a direct threat to military culture and effectiveness, the Pentagon has largely treated the end of Don't Ask, Don't Tell as a policy matter. The difficulties still experienced by women in the armed services 40 years after they were first incorporated in significant numbers indicates that this response will be insufficient to address the deeper cultural issues. Gender issues implicate deeply held beliefs and values that persist even in the face of years of official admonishment and denial. Unless the military begins to transparently bridge the gap between the myth and reality of the modern warrior, military service without discrimination based on sexual orientation will remain an unachieved goal.

  9. The Virtual Cell: a software environment for computational cell biology.

    Science.gov (United States)

    Loew, L M; Schaff, J C

    2001-10-01

    The newly emerging field of computational cell biology requires software tools that address the needs of a broad community of scientists. Cell biological processes are controlled by an interacting set of biochemical and electrophysiological events that are distributed within complex cellular structures. Computational modeling is familiar to researchers in fields such as molecular structure, neurobiology and metabolic pathway engineering, and is rapidly emerging in the area of gene expression. Although some of these established modeling approaches can be adapted to address problems of interest to cell biologists, relatively few software development efforts have been directed at the field as a whole. The Virtual Cell is a computational environment designed for cell biologists as well as for mathematical biologists and bioengineers. It serves to aid the construction of cell biological models and the generation of simulations from them. The system enables the formulation of both compartmental and spatial models, the latter with either idealized or experimentally derived geometries of one, two or three dimensions.

  10. Biocompatibility and anti-microbiological activity characterization of novel coatings for dental implants: A primer for non-biologists

    Science.gov (United States)

    Monsees, Thomas

    2016-08-01

    With regard to biocompatibility, the cardinal requirement for dental implants and other medical devices that are in long-term contact with tissue is that the material does not cause any adverse effect to the patient. To warrant stability and function of the implant, proper osseointegration is a further prerequisite. Cells interact with the implant surface as the interface between bulk material and biological tissue. Whereas structuring, deposition of a thin film or other modifications of the surface are crucial parameters in determining favorable adhesion of cells, corrosion of metal surfaces and release of ions can affect cell viability. Both parameters are usually tested using in vitro cytotoxicity and adhesion assays with bone or fibroblasts cells. For bioactive surface modifications, further tests should be considered for biocompatibility evaluation. Depending on the type of modification, this may include analysis of specific cell functions or the determination of antimicrobial activities. The latter is of special importance as bacteria and yeast present in the oral cavity can be introduced during the implantation process and this may lead to chronic infections and implant failure. An antimicrobial coating of the implant is a way to avoid that. This review describes the essential biocompatibility assays for evaluation of new implant materials required by ISO 10993 and also gives an overview on recent test methods for specific coatings of dental implants.

  11. Biocompatibility and anti-microbiological activity characterization of novel coatings for dental implants: A primer for non-biologists

    Directory of Open Access Journals (Sweden)

    Thomas K Monsees

    2016-08-01

    Full Text Available With regard to biocompatibility, the cardinal requirement for dental implants and other medical devices that are in long-term contact with tissue is that the material does not cause any adverse effect to the patient. To warrant stability and function of the implant, proper osseointegration is a further prerequisite. Cells interact with the implant surface as the interface between bulk material and biological tissue. Whereas structuring, deposition of a thin film or other modifications of the surface are crucial parameters in determining favorable adhesion of cells, corrosion of metal surfaces and release of ions can affect cell viability. Both parameters are usually tested using in vitro cytotoxicity and adhesion assays with bone or fibroblasts cells. For bioactive surface modifications, further tests should be considered for biocompatibility evaluation. Depending on the type of modification, this may include analysis of specific cell functions or the determination of antimicrobial activities. The latter is of special importance as bacteria and yeast present in the oral cavity can be introduced during the implantation process and this may lead to chronic infections and implant failure. An antimicrobial coating of the implant is a way to avoid that. This review describes the essential biocompatibility assays for evaluation of new implant materials required by ISO 10993 and also gives an overview on recent test methods for specific coatings of dental implants.

  12. Don Quixote Pond Sediments: Surface and Subsurface Chemistry and Mineralogy

    Science.gov (United States)

    Englert, P. A. J.; Bishop, J. L.; Patel, S.; Gibson, E. K.; Koeberl, C.

    2014-12-01

    Don Quixote Pond, like Don Juan Pond in the South Fork of Wright Valley, Antarctica, is a model for calcium and chlorine weathering and distribution on Mars. It is located in the western part of the North Fork about 100 m above Mean Seawater Level; its brine is seasonally frozen [1]. Field observations show zones of discoloration which grow lighter with distance from the pond edges. Four sediment cores, a set of radial surface samples, special surface samples, and samples of local rocks were obtained [2]. We report on chemical and mineral analyses of traverse samples and on two cores. Core DQ20 is a northeastern shoreline core. Its soluble salt concentration exceeds 200 micromoles/g in the top 5 cm, and then falls to less than 70 micromoles/g at the permafrost depth of 15 cm. These concentrations are low when compared to similarly positioned locations at Don Juan Pond and to cores from Prospect Mesa close to Lake Vanda, Wright Valley. Halite, soda niter, tachyhydrite and/bischovite are suggested from the ionic molar relationships Measured halite concentrations of surface samples, collected along a traverse of 35 m from the pond outwards, range from over 5% to trace amounts, decreasing with distance. Gypsum is also present in almost all of these samples ranging from 0.2% to 2.6%, but does not exhibit a trend. However, in core DQ35, located at a distance of 15 m along the traverse, gypsum decreases from 2.5% to 0.6% from the surface to the permafrost depth of 12 cm. While DQ35 and radial samples show high quartz and albite abundance, samples that contained visible encrustations and evaporites are low in these minerals and rich in highly diverse alteration products. Don Juan Basin ponds may have formed by a complex surface water mobilization of weathering products [3] and local groundwater action [4,5]. In contrast, Don Quixote pond mineralogy and chemistry may be consistent with a less complex shallow and deep groundwater system origin [1]. [1] Harris H

  13. Don Quixote Pond: A Small Scale Model of Weathering and Salt Accumulation

    Science.gov (United States)

    Englert, P.; Bishop, J. L.; Patel, S. N.; Gibson, E. K.; Koeberl, C.

    2015-01-01

    The formation of Don Quixote Pond in the North Fork of Wright Valley, Antarctica, is a model for unique terrestrial calcium, chlorine, and sulfate weathering, accumulation, and distribution processes. The formation of Don Quixote Pond by simple shallow and deep groundwater contrasts more complex models for Don Juan Pond in the South Fork of Wright Valley. Our study intends to understand the formation of Don Quixote Pond as unique terrestrial processes and as a model for Ca, C1, and S weathering and distribution on Mars.

  14. Bioavailability of dissolved organic nitrogen (DON) in wastewaters from animal feedlots and storage lagoons.

    Science.gov (United States)

    Sun, Jingyi; Khan, Eakalak; Simsek, Senay; Ohm, Jae-Bom; Simsek, Halis

    2017-11-01

    Dissolved organic nitrogen (DON) from animal wastes can contribute to pollution of surface waters. Bioavailable DON (ABDON) is a portion of DON utilized by algae with or without bacteria. This study determined DON and ABDON levels in animal wastewater collected from two different sources: an animal feedlot wastewater storage tank and a sheep wastewater storage lagoon. Inocula for the ABDON bioassays were comprised of individual species and several combinations involving two algae (Chlamydomonas reinhardtii and Chlorella vulgaris) and a mixed liquor suspended solids (MLSS) bacterial culture. The ratio of initial DON to initial total dissolved nitrogen was 18% in the feedlot wastewater samples and 70% in the lagoon wastewater samples. The results showed that between 1.6 and 4.5 mg-NL-1 DON (45-79% of initial DON) in the feedlot samples and between 3.4 and 7.5 mg-NL-1 DON (36%-79% of initial DON) in the lagoon samples were bioavailable with the inocula tested. These results suggest that when considering eutrophication potential of livestock wastewater, organic nitrogen should be included in addition to the obvious culprits, ammonia and nitrate. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).

    Science.gov (United States)

    Tiong, Soon Huat; Looi, Chung Yeng; Arya, Aditya; Wong, Won Fen; Hazni, Hazrina; Mustafa, Mohd Rais; Awang, Khalijah

    2015-04-01

    Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and IR. Vindogentianine is a dimer containing a vindoline moiety coupled to a gentianine moiety. After 24h incubation, vindogentianine exhibited no cytotoxic effect in C2C12 mouse myoblast and β-TC6 mouse pancreatic cells (IC50>50μg/mL). Real-time cell proliferation monitoring also indicated vindogentianine had little or no effect on C2C12 mouse myoblast cell growth at the highest dose tested (200μg/mL), without inducing cell death. Vindogentianine exhibited potential hypoglycemic activity in β-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition. However, in vitro α-amylase and α-glucosidase inhibition assay showed low inhibition under treatment of vindogentianine. This suggests that hypoglycemic activity of vindogentianine may be due to the enhancement of glucose uptake and PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Don Quichotte, un don quichotte ? Déprogrammation d’un stéréotype

    Directory of Open Access Journals (Sweden)

    Marta Cuenca-Godbert

    2009-12-01

    Full Text Available En réaction à la publication de la suite apocryphe de Don Quichotte de la Manche, Cervantès utilise dans sa seconde partie les ressorts narratifs de la stéréotypie littéraire pour montrer à quel point son personnage diffère de ce qu'en a fait Alonso Fernández de Avellaneda, continuateur peu respectueux de sa personne et de son personnage. Le refus de voir en don Quichotte un simple stéréotype du chevalier errant chimérique est particulièrement manifeste dans la série d'aventures se déroulant au château des ducs, où don Quichotte, par sa renommée littéraire littéralement reconnue, est traité en chevalier par des personnages manipulateurs de situations, qui visent à produire chez lui des réactions programmées pour s’en amuser. Il apparaît alors que le simple agrégat d'ingrédients propres au stéréotype littéraire chevaleresque finit par ne pas produire l'issue escomptée.En la Segunda parte del Quijote, Cervantes reacciona ante la publicación de la de Alonso Fernández de Avellaneda, continuador poco respetuoso con la persona del autor primigenio y su personaje. Recurriendo a los procedimientos narrativos de la estereotipia literaria deja bien claro qué diferente resulta ser el personaje original respecto al del continuador. La negativa de ver a don Quijote como un mero estereotipo del caballero andante loco se pone particularmente de manifiesto en la serie de aventuras que transcurren en el palacio de los duques. Allí, los personajes reconocen literalmente la fama literaria de don Quijote. Generan, desde situaciones ficticias, tipos de tratamiento que se dispensarían a un verdadero caballero andante. Como resultado, se desencadena una serie de reacciones programadas con las que pretenden divertirse. Sin embargo, queda claro que la mera acumulación de ingredientes propios del estereotipo literario caballeresco no produce el resultado esperado.

  17. A Novel Source of DOC and DON to Watershed Soils

    Science.gov (United States)

    Aitkenhead-Peterson, J. A.

    2017-12-01

    A source of dissolved organic carbon (DOC) and nitrogen (DON) to soils and groundwater is that emanating from decomposing mammals. Although there is an increase in human donor facilities (body farms) in the USA and in mass mortality events (MME) worldwide, this injection of DOC and DON into watershed soils has received little attention. Studies at two human donor facilities in Texas, USA have revealed that the purge fluid associated with decomposition is extremely high in DOC and DON and migrates down the soil profile. Two studies were carried out 1) The southeast Texas Applied Forensic Science (STAFS) facility on an Alfisol with a saturated hydraulic conductivity of 331 mm hr-1 and 83% sand and 2) the Forensic Anthropology Research Facility (FARF) on Mollisols with a saturated hydraulic conductivity of 3.6-9.7 mm hr-1 and 28-33% sand. The numbers of days since donors were laid in the environment ranged from 219-680 d at STAFS and 306-960 d at FACTS. Purge can occur between 5 and 30 d dependent on the time of year the body is placed and the resultant phenomenon is termed cadaver decomposition island (CDI). Soil cores were taken at 5 cm increments to a depth of 30 cm in the sandy soil and 15 cm in the clayey/rocky soil. In the sandy soils, DOC concentrations were significantly higher in all the CDI soils when compared to control soils at depths of 15, 20, 25 and 30 cm and ranged from 121.7 µg g-1 (30 cm) to 167.6 µg g-1 (15 cm) in control soils and 461.9 µg g-1 (30 cm) to 660.4 µg g-1 (15 cm) in CDI soils, representing a three- to four-fold increase in DOC relative to control soils. DON in all CDI soils was not significantly higher than control soils until 30 cm depth and ranged from 9.9-32.3 µg g-1 in CDI soils and 121.7 µg g-1 in control soil, representing a two- to seven-fold increase in DON relative to control soils. DOC concentrations in control soils at the FARF site at 15 cm ranged 215-365 µg g-1 while in the CDI soils DOC was higher (range: 270

  18. Don Quijote en Brasil: de la mitología a las historietas

    Directory of Open Access Journals (Sweden)

    Kenia Almeida Pereira

    2009-11-01

    Full Text Available Este artículo es una pequeña reflexión sobre el libro El ingenioso hidalgo Don Quijote de la Mancha, de Miguel de Cervantes, publicada en 1605. Esta obra ha sido considerada como una de las mejores novelas de todos los tiempos. En ella podemos transitar de lo popular a lo erudito. Esta narrativa está llena de antítesis y metáforas barrocas que contienen desde los refranes populares hasta la erudición de los mitos griegos, así como de la locura y jocosidad de Don Quijote y también de la mediocridad y lucidez de Sancho Panza.

  19. "Deficits Don't Matter": Abundance, Indebtedness and American Culture.

    Science.gov (United States)

    Kroes, Rob

    If deficits, nor defaults, don't really matter anymore, what sign of our times is it? What has changed from the days that Franklin Delano Roosevelt risked the fragile economic recovery from the great depression by returning, in 1937, to the standard of his economic orthodoxy, a belief in fiscal rectitude and anaversion to debts and deficits? If that was a sign of a certain American character, what has happened to it? A massive shift in public culture must have occurred, affecting people's views on public probity and political rectitude. The following is an attempt to trace some of the main shifts on the way to our present quandary.

  20. Aspectos literarios de la obra de don Joan de Castellanos

    Directory of Open Access Journals (Sweden)

    Mario Germán Romero

    1966-09-01

    Full Text Available Capítulo XIV Voces castizas que no figuran en el diccionario de la academia (I Con el título de Dos mil quinientas voces castizas y bien autorizadas que piden lugar en nuestro léxico, publicó don Francisco Rodríguez Marín un interesante libro en Madrid, 1922. El erudito comentador del Quijote estudió cuidadosamente los autores españoles de los siglos XV, XVI y XVII.

  1. Signs of revision in Don Quixote, Part II

    Directory of Open Access Journals (Sweden)

    Gonzalo Pontón

    2016-11-01

    Full Text Available This article provides new evidences in favour of the hypothesis that Cervantes, after finishing Don Quixote, Part II, partially revised the original, introducing some significant changes and additions, mainly in the last chapters. The analysis of some narrative inconsistencies, that cannot be interpreted as mere mistakes but as significant textual traces, reveals a process of re-elaboration –a process that affects at least four sections of the novel. Most of the evidence gathered here suggests that this revision is closely linked to Avellaneda’s continuation, in the sense that Cervantes tried to challenge the apocriphal Quixote making last-time interventions in his own text.

  2. Don, Betty and Jackie Kennedy: On Mad Men and Periodisation

    Directory of Open Access Journals (Sweden)

    Prudence Black

    2012-09-01

    Full Text Available Why is it that we watch Mad Men and think it represents a period? Flashes of patterned wallpaper, whiskey neat, babies born that are never mentioned, contact lining for kitchen drawers, Ayn Rand, polaroids, skinny ties, Hilton hotels, Walter Cronkite, and a time when Don Draper can ask ‘What do women want?’ and dry old Roger Sterling can reply ‘Who Cares?’ This essay explores the embrace of period detail in Mad Men finding it to be both loving and fetishistic, and belonging, like all period film, to the politics of the present.

  3. Don Quijote cabalga de nuevo: reescrituras del mito quijotesco

    OpenAIRE

    Pardo García, Pedro Javier

    2013-01-01

    [ES]El texto se ocupa de la fortuna de Don Quijote de la Mancha en el cine durante el período tardofranquista. Para ello, utiliza como marco teórico la noción de reescritura frente a la tradicional de adaptación, que ilustra mediante dos obras de teatro que reescriben el Quijote y representan las dos variantes fundamentales de esta práctica (homodiegética y heterodiegética), a saber, la Dulcinea (1938) de Gaston Baty y Una tal Dulcinea (1961) de Alfonso Paso. A continuación traslada el estudi...

  4. [Pica, a strange symptom unveiled even in "Don Quixote"].

    Science.gov (United States)

    Larraín, Camilo

    2005-05-01

    Pica, the compulsive eating of non edible substances, is known by the medical profession for centuries. In the novel by Miguel de Cervantes "Adventures of the famous knight Don Quixote de la Mancha'', there is a history in which "women that by caprice eat soil, plaster coal and other disgusting substances'' are mentioned. This description configures the clinical diagnosis of pica. This fact has not attracted the attention of the critics of Cervantes' novel, up to now. This unequivocal reference of pica suggests that iron deficiency anemia, caused by chronic hemorrhages in adults, was frequent in 1605, when the book was first published.

  5. The Generation of 1898 and Cervantes : The invention of Don Quixote as a national symbol

    NARCIS (Netherlands)

    Storm, H.J.; Achiri, N.; Baraibar, A.; Schmelzer, F.K.E.

    2015-01-01

    Don Quixote became a Spanish national symbol thanks to the authors the Generation of 1898, such as Miguel de Unamuno, Azorín and Francisco Navarra Ledesma, who published their new interpretations during the 1905 commemoration of the publication of Cervantes', The Ingenious Gentleman Don Quixote of

  6. Le Don De Corps En Cote D\\'ivoire | Broalet | African Journal of ...

    African Journals Online (AJOL)

    Introduction Le don de corps qui permet de se procurer le matériel anatomique de dissection que constitue le cadavre humain n\\'existe pas en Afrique noire et notamment en Cote d\\' Ivoire. Objectif Recueillir des informations sur le don de corps à Abidjan. Méthode Les auteurs rapportent les informations recueillies au cours ...

  7. Intergroup Contact, Prejudicial Attitudes, and Policy Preferences: The Case of the U.S. Military's "Don't Ask, Don't Tell" Policy.

    Science.gov (United States)

    Harwood, Jake

    2015-01-01

    Data from 115,052 active United States military personnel were analyzed to explore links between contact with gay people and attitudes about repealing "Don't Ask, Don't Tell." Results showed that prejudice against homosexuals significantly mediated the association between contact and supporting repeal of "Don't Ask, Don't Tell"; quality of contact in the military was a stronger predictor than other measures of contact. Quality and quantity of contact interacted: more contact quantity had opposing statistical effects on policy attitudes for people experiencing high versus low quality contact. Findings are discussed in terms of contact theory, the association between intergroup attitudes and policy preferences, and practical implications for situations in which groups' access to new positions or roles is limited, and hence contact opportunities are rare.

  8. Blood Pressure Medicines Don’t Work If People Don’t Take Them PSA (:60)

    Centers for Disease Control (CDC) Podcasts

    2016-09-13

    This 60 second public service announcement is based on the September 2016 CDC Vital Signs report. Blood pressure medicines don’t work if people don’t take them. Learn how health care systems can work with patients to make taking medicines easier.  Created: 9/13/2016 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 9/13/2016.

  9. Microbial Detoxification of Deoxynivalenol (DON), Assessed via a Lemna minor L. Bioassay, through Biotransformation to 3-epi-DON and 3-epi-DOM-1.

    Science.gov (United States)

    Vanhoutte, Ilse; De Mets, Laura; De Boevre, Marthe; Uka, Valdet; Di Mavungu, José Diana; De Saeger, Sarah; De Gelder, Leen; Audenaert, Kris

    2017-02-13

    Mycotoxins are toxic metabolites produced by fungi. To mitigate mycotoxins in food or feed, biotransformation is an emerging technology in which microorganisms degrade toxins into non-toxic metabolites. To monitor deoxynivalenol (DON) biotransformation, analytical tools such as ELISA and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) are typically used. However, these techniques do not give a decisive answer about the remaining toxicity of possible biotransformation products. Hence, a bioassay using Lemna minor L. was developed. A dose-response analysis revealed significant inhibition in the growth of L. minor exposed to DON concentrations of 0.25 mg/L and higher. Concentrations above 1 mg/L were lethal for the plant. This bioassay is far more sensitive than previously described systems. The bioassay was implemented to screen microbial enrichment cultures, originating from rumen fluid, soil, digestate and activated sludge, on their biotransformation and detoxification capability of DON. The enrichment cultures originating from soil and activated sludge were capable of detoxifying and degrading 5 and 50 mg/L DON. In addition, the metabolites 3-epi-DON and the epimer of de-epoxy-DON (3-epi-DOM-1) were found as biotransformation products of both consortia. Our work provides a new valuable tool to screen microbial cultures for their detoxification capacity.

  10. Don Quijote y Sancho Panza: duelo hiperbólico

    Directory of Open Access Journals (Sweden)

    María Stoopen

    2015-06-01

    Full Text Available Mientras don Quijote queda en Sierra Morena haciendo penitencia de amor por Dulcinea, Sancho Panza se encamina al Toboso a entregar a la amada una carta del caballero (Quijote I, 25. El escudero conoce ya la verdadera identidad de la señora que inspira los actos de su amo, “la moza labradora” Aldonza Lorenzo. El hecho de que Sancho no llegue al Toboso, y en consecuencia no vea nunca a la doncella ni le entregue ninguna carta, suscita en la descripción posterior que hace a su amo una serie de invenciones degradantes sobre la identidad de la joven construidas por el labrador a partir del imaginario rural. Se establece así un duelo hiperbólico de doble signo en donde don Quijote se ve forzado a adaptar las imágenes con que Sancho describe a Aldonza-Dulcinea, que no corresponden al ideal amoroso con que concibe a su amada (Quijote I, 30-31. Haré aquí un análisis de los recursos persuasivos que cada protagonista utiliza y del choque semántico que se establece a partir de los códigos de referencia de uno y otro. Asimismo, consideraré las consecuencias de estos episodios en la relación entre amo y escudero y la degradación creciente que sufre la imagen de la amada del caballero, gracias al poder discursivo de Sancho Panza.

  11. [Joséphine Schouteden-Wéry on the Belgian coast: a biologist involved in field work and collection building].

    Science.gov (United States)

    Heizer, Alda; Cerqueira, Aline Cardoso

    2014-01-01

    This text presents the findings and other aspects about the fieldwork of biologist Joséphine Schouteden-Wéry on the coast of Belgium. The information is taken from an article published in 1911 in Recueil de L'Institut Botanique Léo Errera, a periodical of the University of Brussels. Schouteden-Wéry replied to the Royal Society for Medical and Natural Sciences of Brussels (Société Royale des Sciences Médicales et Naturelles de Bruxelles) about the geological, climatic, hydrological and other factors that regulate the geographical distribution of species. She took part in study trips to the Congo, a Belgian colony in Africa, and was a leading member of the Union of Colonial Women (L'Union des Femmes Coloniales).

  12. ‘Early Psychosis’ as a Mirror of Biologist Controversies in Post-WarGerman, Anglo-Saxon and Soviet Psychiatry

    Directory of Open Access Journals (Sweden)

    Lara eRzesnitzek

    2013-07-01

    Full Text Available The English term ‘early psychosis’ was coined in the 1930s to refer to feelings of irritability, loss of concentration, hypochondriac ideas, moodiness and lassitude that were seen to precede the onset of clear-cut hallucinations and delusions. The history of thinking about ‘early psychosis’ under names such as ‘latent’, ‘masked’, ‘mild’, ‘simple’ or ‘sluggish’ schizophrenia before World War II and afterwards on the different sides of the Wall and the Iron Curtain reveals ‘early psychosis’ as a mirror of quite aged international biologist controversies that are still alive today and to the same extent as they are misunderstood, are influential in their implications in today’s psychiatry.

  13. Doña Clara e don Luis: l’ennesima 'questione amorosa' all’interno della "venta de Palomeque" (Don Quijote, I, 32-47

    Directory of Open Access Journals (Sweden)

    A. Candeloro

    2012-08-01

    Full Text Available ITDoña Clara e don Luis rappresentano l’ultima coppia d’innamorati che raggiunge la locanda di Palomeque, all’interno di quella serie di disavventure e riconoscimenti insperati che danno vita allo “escandaloso happy end” – come lo definirà ironicamente Juan Benet – nel quale si risolve l’azione principale connessa alle numerose trame secondarie  sviluppate proprio nello spazio “scenico” della famosa locanda. Scopo di questo studio è quello di analizzare le caratteristiche e le problematiche legate alla “questione amorosa” di doña Clara e don Luis, il modo in cui nasce e si sviluppa tale intreccio e le tecniche narrative attraverso cui Cervantes ricollega e amalgama questa storia d’amore a quelle delle altre coppie presenti nella conclusione della Primera Parte del Quijote.ENDoña Clara and don Luis are the last couple of lovers arriving to Palomeque's inn. They are the umpteenth romantic couple in a string of episodes based on several recognition scenes between different couples.  That's why they contribute to reach that "scandalous happy end" – as Juan Benet ironically defined it –, through which the main action of the novel's plot comes to a conclusion and allows to finish, at the same time, all the secondary plots at the inn. This report aims to analyze the characteristics and problems related to "the love issue" between Doña Clara and don Luis and, in special, all the particular narrative techniques which Cervantes uses to link this "love story" with other couples in the first part of Don Quijote.Keywords: Cervantes – Don Quijote – narrative techniques – Doña Clara and Don Luis – love question

  14. Basic statistics in cell biology.

    Science.gov (United States)

    Vaux, David L

    2014-01-01

    The physicist Ernest Rutherford said, "If your experiment needs statistics, you ought to have done a better experiment." Although this aphorism remains true for much of today's research in cell biology, a basic understanding of statistics can be useful to cell biologists to help in monitoring the conduct of their experiments, in interpreting the results, in presenting them in publications, and when critically evaluating research by others. However, training in statistics is often focused on the sophisticated needs of clinical researchers, psychologists, and epidemiologists, whose conclusions depend wholly on statistics, rather than the practical needs of cell biologists, whose experiments often provide evidence that is not statistical in nature. This review describes some of the basic statistical principles that may be of use to experimental biologists, but it does not cover the sophisticated statistics needed for papers that contain evidence of no other kind.

  15. Don Quixote-A possible parent body of a meteor shower

    Science.gov (United States)

    Rudawska, Regina; Vaubaillon, Jeremie

    2015-12-01

    Asteroid 3552 Don Quixote (1983 SA) orbits the Sun on an orbit that resembles that of a short-period comet. This, together with its recently observed cometary activity, makes it a good candidate for a parent body of a meteor shower. Model calculations show that the particles originated from Don Quixote pass close enough to Earth orbit to search for a meteor shower activity. Corresponding meteor showers were found in CAMS (Rudawska and Jenniskens, 2014) and EDMOND (Kornoš et al., 2014) video observations. The κ Lyrids and August μ Draconids (IAU#464 and IAU#470, respectively), a similarly inclined stream active in the summer, are associated with 3552 Don Quixote.

  16. Anatomical characters of the phyllode and stem of Acacia podalyriifolia A. Cunn. ex G. Don (Fabaceae

    Directory of Open Access Journals (Sweden)

    M.R. Duarte

    Full Text Available The Acacia genus has presented various secondary metabolites, such as tannins, flavonoids, alkaloids and gums. Preparations from different species have been applied for diabetes, gastrointestinal disorders and inflammatory diseases in the traditional medicine and have demonstrated cytotoxic, antimicrobial and antiparasitic activities. Acacia podalyriifolia A. Cunn. ex G. Don (Fabaceae is a small wood, indigenous to Australia and cultivated worldwide for its ornamental feature. This work aimed to characterize the anatomy of the phyllode and stem, in order to contribute to the species identification. The botanical material was fixed, sectioned and prepared according to usual light and scanning microtechniques. The epidermal cells, in surface view, are polygonal and coated with striate and thick cuticle, and filaments of epicuticular wax. Paracytic stomata and unicellular non-glandular trichomes are seen. Palisade and ground parenchymas, and minor collateral bundles with xylem directed alternately to upper and lower sides occur in the blade. The midrib shows two collateral bundles facing each other. The stem, in incipient secondary growth, exhibits epidermis, annular collenchyma, sclerenchymatic sheath and collateral vascular organization. Cells containing phenolic compounds and prisms of calcium oxalate are observed.

  17. Studies on phytosterol content of Parkia roxburgii G. Don.

    Directory of Open Access Journals (Sweden)

    DJADJAT TISNADJAJA

    2006-01-01

    Full Text Available Kedawung (Parkia roxburgii G. Don. is one of plants that originally could be found in almost all parts of Java Island. Due to lack of attention, at present situation this plant could be categorized as an endangered species. This plant species distributed widely in Africa. In several African countries, this plant has an important position either as food resource or alternative medicine. In Indonesia, traditionally kedawung tree often use as medicine, especially as part of “jamu gendong” formulation. This work was focused on the study of phytosterol content and it distribution. The research result show that almost all parts of kedawung tree have a significant content of phytosterol, which is dominated by beta-sitosterol. The highest beta-sitosterol content was founded in the stem of leaf (35.24% (w/w and pod (29.67% (w/w.

  18. Efectos embriotóxicos de Picrosia longifolia Don (Asteraceae

    Directory of Open Access Journals (Sweden)

    Victor Benavides

    2014-06-01

    Full Text Available Se ha evaluado los probables efectos tóxicos del extracto acuoso de Picrosia longifolia Don “Achicoria” sobre el desarrollo de embriones preimplantacionales de ratón. Extracto acuoso de P. longifolia al 20%, 10% y 0% fue suministrado a ratonas preñadas hasta las 86 horas postcópula (hpc. Al evaluar el estadio embrionario se encontró que el extracto acuoso de P. longifolia al 10% y 20% causó retraso en el desarrollo embrionario. También se observó una disminución en la viabilidad embrionaria en los grupos tratados. Tanto la disminución de viabilidad como el retraso en el desarrollo se produjo en una forma dosis dependiente.

  19. Don Giovanni Goes to Prison: Teaching Opera behind Bars

    Directory of Open Access Journals (Sweden)

    Pierpaolo Polzonetti

    2016-12-01

    Full Text Available Teaching opera in prison presents challenges, such as limits imposed on printed and recorded material to study it, or the audio-visual technology in the classroom space, yet, no other experience can be so inspiring and rewarding for everybody involved. This essay focuses on teaching opera, in particular Mozart’s Don Giovanni, to imprisoned students in America. It addresses pedagogical challenges on how to teach opera in prison and advocates for the need to leave the ivory tower of academia and engage in social action. If opera is still perceived as an elitist art form, it is because it is artificially kept that way by being practiced, taught, studied, and promoted only among an exclusive sector of our population.

  20. Mission Analysis for the Don Quijote Phase-A Study

    Science.gov (United States)

    Cano, Juan L.; Sanchez, Mariano; Cornara, Stefania; Carnelli, Ian

    2007-01-01

    The Don Quijote Phase-A study is a definition study funded by ESA and devoted to the analysis of the possibilities to deflect a Near Earth Object (NEO) in the range of 300-800 m diameter. DEIMOS Space S.L. and EADS Astrium have teamed up within this study to form one of the three consortia that have analyzed these aspects for ESA. Target asteroids for the mission are 1989 ML, 2002 AT4 and Apophis. This paper presents the mission analysis activities within the consortium providing: low-thrust interplanetary rendezvous Orbiter trajectories to the target asteroids, ballistic interplanetary trajectories for the Impactor, Orbiter arrival description at the asteroids, Orbiter stable orbits characterization at the asteroid, deflection determination by means of a Radio Science Experiment (RSE) as well as the mission timelines and overall mission scenarios.

  1. Atlarda Alaca Don ve Türkiye’deki Alaca Atlar

    OpenAIRE

    KÖSEMAN, Abdurahman; ŞEKER, İbrahim

    2016-01-01

    Bu çalışma genel olarak atlarda seyrek olarak görülen alaca don ile Türkiye’de oldukça sınırlı birbölgede yetiştiriciliği yapılan ve az sayıda popülasyona sahip alaca atlar ile ilgili bazı bilgileri sunmak amacıylagerçekleştirilmiştir. At yetiştiriciliğinde ırk düzeyinde saflığı koruyabilmek ve ekonomik önem taşıyan özelliklerigeliştirebilmek önemlidir. Bunun için ırklara ait morfolojik ve fzyolojik karakterlerin tespiti ile fenotipik vegenotipik parametrelerin ortaya konulması gerekir. Atın m...

  2. Scientific Communication for Positive Action: Do's and Don'ts

    Science.gov (United States)

    Sanquini, A.; Wood, M. M.

    2015-12-01

    Natural hazard presentations often highlight disasters that may ensue from natural processes when mitigation or preparedness actions are not taken. Examples include images of raging fires, collapsed buildings, and flooded urban areas. Research has shown that this makes presentations more interesting and more memorable. Such images are the stock and trade of disaster reporting by the media. Unfortunately, it may also trigger avoidance and denial in the audience, resulting in preparedness reduction; the opposite effect of what may have been intended by the speaker. Recent social research has provided insight into a better approach. The theory of communicating actionable risk posits that people will take action against hazards when they know what to do, think it would work, and know someone who did it. This approach was recently applied in an intervention designed to motivate earthquake-resistant construction in Kathmandu Valley, Nepal. Social theory further suggests that a tendency towards action is strengthened by hearing a consistent message over time, and by providing the audience with an appropriate opportunity to seek out relevant information. This presentation shows how, by taking this transdisciplinary step, scientists can make small changes in their hazard communication, thereby acting as positive influencers of change. A summary of "do's" and "don'ts" is given for reference. 1. Show examples of what to do. 2. Show effectiveness of actions. 3. Give sense of knowing someone who did it. 4. Deliver consistent message, repeatedly. 5. Give opportunity for more information. DON'T: 1. Make the disaster the star. 2. Contradict other communications.

  3. NMR for chemists and biologists

    CERN Document Server

    Carbajo, Rodrigo J

    2013-01-01

    This book offers a concise introduction to the field of nuclear magnetic resonance or NMR. It presents the basic foundations of NMR in a non-mathematical way and provides an overview of both recent and important biological applications of NMR.

  4. Mendelian randomization: A biologist's perspective

    Directory of Open Access Journals (Sweden)

    Subhoshree Ghose

    2016-01-01

    Full Text Available Mendelian randomization (MR is a statistical technique used by genetic epidemiologists to determine causal effects, i.e. whether a biomarker actually influences disease risk, is it just a statistical association. It uses common genetic polymorphisms with known biological effects (propensity to drink alcohol or effects that mimic modifiable exposures (raised blood cholesterol. For MR, it is necessary that the genotype only affects the disease status indirectly through its effect on the exposure of interest.

  5. Reproducible Bioinformatics Research for Biologists

    Science.gov (United States)

    This book chapter describes the current Big Data problem in Bioinformatics and the resulting issues with performing reproducible computational research. The core of the chapter provides guidelines and summaries of current tools/techniques that a noncomputational researcher would need to learn to pe...

  6. Stem cell migration - Methods and protocols

    Directory of Open Access Journals (Sweden)

    Carlo Alberto Redi

    2012-03-01

    Full Text Available The trafficking of stem cells is something unconsciously clear to any biologists (e.g., developmental biologists and physicians (e.g., all those taking care of hematopoietic and bone diseases and traumas; neverthless it is a phenomenon coming out as a hot topic just in these last years. Likely, the difficulties to track stem cells migration in vivo and the understanding of the elusive homing signals matching the circulating stem cells properties that makes these cells to stop and to start multiplication and differentiation....

  7. Have a Baby or Young Child With a Cold? Most Don't Need Medicines

    Science.gov (United States)

    ... Products For Consumers Home For Consumers Consumer Updates Most Young Children With a Cough or Cold Don' ... cold? It depends on the child’s age. Although most colds in children don’t have serious complications, ...

  8. ???????????? ? ?????????? ??????? ??????? ?? ??????? ???????????? ? ?????? ???????-??-???? // Advantages and disadvantages of franchise business opportunities in Rostov-on-don

    OpenAIRE

    Bugayan, S.A.; Filimonenko, I.

    2013-01-01

    ? ?????? ??????????? ???????? ???????????? ? ?????????? ??????????? ??????? ?? ??????? ???????????? ? ?????? ???????-??-???? ?? ??????? ????????? ????, ????????????? ??????? ???? ????? ??????? ? ?? ?????????? ??????????? ????????. In this article are considered main cons and pros of franchise business opportunities in Rostov-on-Don, using different businesses as an example,efficiency of this type of business and its future possibilities.

  9. Open Questions: We don't really know anything, do we? Open questions in sensory biology.

    Science.gov (United States)

    Johnsen, Sönke

    2017-05-17

    Senses connect organisms to both the world and to each other, yet there is much we don't know about them. Using examples drawn primarily from the author's subfield of vision research, this article discusses five major open questions.

  10. Pilot Fullerton dons EES anti-gravity suit lower torso on middeck

    Science.gov (United States)

    1982-01-01

    Pilot Fullerton dons ejection escape suit (EES) anti-gravity (anti-g) suit lower torso on forward port side middeck above potable water tank. Anti-g suit is an olive drab inner garment that complements EES.

  11. Make the call, don't miss a beat: Heart Attack Information for Women

    Science.gov (United States)

    ... Other resources Learn more about heart disease and heart attacks. Make the Call, Don't Miss a Beat ... symptoms Learn the 7 most common signs of heart attack in men and women. Chest pain or discomfort " ...

  12. Don't make me think: a common sense approach to Web usability

    National Research Council Canada - National Science Library

    Krug, Steve

    2006-01-01

    .... To ensure that your sites provide that experience, this guide from usability guru Krug distills his years of on-the-job experience into a practical primer on the do's and don'ts of good Web design...

  13. Occurrence of Deoxynivalenol (DON in wheat flours in Guilan Province, northern Iran

    Directory of Open Access Journals (Sweden)

    Reza Kazemi Darsanaki

    2015-02-01

    Full Text Available [b]Introduction and objective.[/b] Deoxynivalenol (DON is one of several mycotoxins produced by certain Fusarium species that frequently infect wheat, corn, rice, oats, barley and other grains in the field or during storage. Guilan, Golestan and Mazandaran areas are located in the North Iran with favorite conditions for [i]Fusarium[/i] growth. DON affects animal and human health causing vomiting, acute temporary nausea, diarrhea, abdominal pain, headache, dizziness, and fever. [b]Materials and methods[/b]. In this study, a total of 96 wheat flour samples of different types were collected during summer 2013 from six flour mills in Northern Iran. All samples were analyzed for DON by enzyme-linked immunosorbent assay. [b]Results[/b]. DON was detected in 80 out of 96 wheat flour samples (83.33%, at levels ranging from 23 to1270 µg/kg. The maximum contamination level of DON (1270 μg/kg was found in whole flour while the minimum value (23 μg/kg was registered in debranned flour. The mean of contamination was 630.53 µg/kg. [b]Conclusions[/b]. According to results obtained, incidence and contamination levels of DON, seem to be a serious problem for public health. Therefore, cereal and cereal based foods should be controlled for the presence of toxins, storage conditions and moisture content, which is considered a major factor in the growth of the [i]Fusarium[/i] fungi.

  14. Demistifikasi Tokoh Don Juan dalam La Nuit De Valognes Karya Eric-Emmanuel Schmitt

    Directory of Open Access Journals (Sweden)

    Talha Bachmid

    2006-10-01

    Full Text Available Don Juan is a myth about a seducer, a man with many love adventures, a women’s heat conqueror, and many other predicates. Don Juan as a myth is well-known world wide over, appearing in about 50 writings such as novels, plays, operas. But a French writer Eric-Emannuel Schmitt proposes a new figure of Don Juan in his play La Nuit de Valognes (Night in Valognes: the seducer is judged by five victims and convicted to marry one of his victims in order to stop his adventures. Surprisingly, Don Juan accepts this verdict without conditions. This sudden change becomes the theme of the play: the demythification of Don Juan. A flash back scene shows the beginning of this change and the interpretations that might arise from here. One possible interpretation is proposed and discussed in this paper: Don Juan found the way to a purer love, which is the union with God, and decides to begin his journey. This play can thus be categorised as a sufi text.

  15. Fuel elements assembling for the DON project exponential experience; Montaje de los elementos combustibles para la experiencia exponencial del proyecto DON

    Energy Technology Data Exchange (ETDEWEB)

    Anca Abati, R. de

    1966-07-01

    It is described the fuel unit used in the DON exponential experience, the manufacturing installments and tools as well as the stages in the fabrication.These 74 elements contain each 19 cartridges loaded with synterized urania, uranium carbide and indium, gold, and manganese probes. They were arranged in calandria-like tubes and the process-tube. This last one containing a cooling liquid simulating the reactor organic. Besides being used in the DON reactor exponential experience they were used in critic essays by the substitution method in the French reactor AQUILON II. (Author) 6 refs.

  16. Authority as paradox: the transformations of Don Quijote.

    Science.gov (United States)

    Priel, Beatriz

    2006-12-01

    The author's contention is that the analysand's temporary attribution of authority to the analyst is inherent in the analytic situation; this is seen as a transitional and paradoxical form of authority pertaining neither to internal nor external reality, but dwelling in the analytic third. The author proposes a conceptualization of psychoanalytic authority as a form of aesthetic authority according to Gadamer's definitions. While the scientific and hermeneutic codes for the understanding of authority in psychoanalysis assume that the main issue at stake is the delimitation of the objectivity or the subjectivity of the analyst's knowledge, this aesthetic perspective centres on the analysand's attribution of a claim of truth to analytic interpretations, and on the experience of recognition. The experience of recognition of a possible truth is particular and context-bound, as well as self-transformational. A reading of three episodes from Cervantes's The history of Don Quixote de la Mancha illuminates the transitional and paradoxical character of aesthetic authority within a transformational dialogue. These episodes are read as dramatizations of different positions vis-à-vis the paradoxical authority that characterizes transformational dialogues.

  17. Simulating and Simulated Characters, Entangled in Don Quixote

    Directory of Open Access Journals (Sweden)

    Vicente Pérez de León

    2014-12-01

    Full Text Available One of the keys for understanding the ruling universe is the nature of the interconnected duality that governs it. It is neither completely monistic, neither absolutely nihilistic, according to the principle of the Platonic symploke (the Sophist 251, 255. The validity of the entanglement between “not everything are monisms” and the fact that reality is not completely “nihilist” will be used as a logic tool to understand the alternation in the understanding of the conclusions of the existences of several of the protagonists of the Quixote. On the one hand, it is the strange case of the suicidal shepherd Grisóstomo, in desperation for his loved Marcela, which is studied in the context of a similar case, the death of Anselmo in The Tale of Ill-advised Curiosity. On the other hand it is the case of the exemplary archetypical death of Don Quixote and his revival in Alonso Quijano “the good”, which presents a similar case of (misunderstanding of the symploke principle. In conclusion, the ontological tragedy arising from not understanding or questioning the Platonic principle of the symploke will contribute to explain the attachment, identification, and nature of the entanglement between reality and fiction in selected cervantine characters. This will be achieved by focusing in both their self-awareness as creative beings and their more or less voluntary inclusion in, or exclusion from, their own simulated realities.

  18. You Don't Look Like a Physicist

    Science.gov (United States)

    Santos, Antonio Carlos Fontes

    2017-12-01

    "You don't look like a physicist!" "Sorry, this bus only goes to the university, Sir." "Where are you going, sir?" "So, you are a university professor? But a substitute one, aren't you?" "OK, you're a professor, but do you do research?" As a person of color teaching physics in Brazil, those are some comments that I usually hear. They are consequences of stereotypes, prejudices, and discrimination, which are related but different ideas. Stereotypes indicate expectations and beliefs about an individual or a group, prejudice denotes feelings, and discrimination expresses behaviors. People are likely to be astonished whenever a Black person says that he or she is a physicist. This paper aims to raise awareness of the underrepresentation of Black physics professors and researchers in Brazil and how the lack of quality high school physics education impacts Black and poor students in Brazil. Finally, some considerations on how physics education can assist minority students in overcoming social barriers that contribute to their underrepresentation are presented.

  19. Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway

    International Nuclear Information System (INIS)

    Mishra, Sakshi; Tripathi, Anurag; Chaudhari, Bhushan P.; Dwivedi, Premendra D.; Pandey, Haushila P.; Das, Mukul

    2014-01-01

    Several toxicological manifestations of deoxynivalenol (DON), a mycotoxin, are well documented; however, dermal toxicity is not yet explored. The effect of topical application of DON to mice was studied using markers of skin proliferation, inflammation and tumor promotion. Single topical application of DON (84–672 nmol/mouse) significantly enhanced dermal hyperplasia and skin edema. DON (336 and 672 nmol) caused significant enhancement in [ 3 H]-thymidine uptake in DNA along with increased myeloperoxidase and ornithine decarboxylase activities, suggesting tissue inflammation and cell proliferation. Furthermore, DON (168 nmol) caused enhanced expression of RAS, and phosphorylation of PI3K/Akt, ERK, JNK and p38 MAPKs. DON exposure also showed activation of transcription factors, c-fos, c-jun and NF-κB along with phosphorylation of IkBα. Enhanced phosphorylation of NF-κB by DON caused over expression of target proteins, COX-2, cyclin D1 and iNOS in skin. Though a single topical application of DMBA followed by twice weekly application of DON (84 and 168 nmol) showed no tumorigenesis after 24 weeks, however, histopathological studies suggested hyperplasia of the epidermis and hypertrophy of hair follicles. Interestingly, intestine was also found to be affected as enlarged Peyer's patches were observed, suggesting inflammatory effects which were supported by elevation of inflammatory cytokines after 24 weeks of topical application of DON. These results suggest that DON induced cell proliferation in mouse skin is through the activation of MAPK signaling pathway involving transcription factors NFκB and AP-1, further leading to transcriptional activation of downstream target proteins c-fos, c-jun, cyclin D1, iNOS and COX-2 which might be responsible for its inflammatory potential. - Highlights: • Topical application of DON enhanced epidermal inflammation and cell proliferation. • DON follows PI3K/Akt/MAPK signaling cascade, with activation of AP-1 and NF

  20. Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, Sakshi [Food Drug and Chemical Toxicology, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226 001 (India); Department of Biochemistry, Banaras Hindu University (BHU), Varanasi (India); Tripathi, Anurag [Food Drug and Chemical Toxicology, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226 001 (India); Chaudhari, Bhushan P. [Pathology Laboratory, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Mahatma Gandhi Marg, PO Box 80, Lucknow 226001, Uttar Pradesh (India); Dwivedi, Premendra D. [Food Drug and Chemical Toxicology, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226 001 (India); Pandey, Haushila P. [Department of Biochemistry, Banaras Hindu University (BHU), Varanasi (India); Das, Mukul, E-mail: mditrc@rediffmail.com [Food Drug and Chemical Toxicology, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), P.O. Box No. 80, Mahatma Gandhi Marg, Lucknow 226 001 (India)

    2014-09-01

    Several toxicological manifestations of deoxynivalenol (DON), a mycotoxin, are well documented; however, dermal toxicity is not yet explored. The effect of topical application of DON to mice was studied using markers of skin proliferation, inflammation and tumor promotion. Single topical application of DON (84–672 nmol/mouse) significantly enhanced dermal hyperplasia and skin edema. DON (336 and 672 nmol) caused significant enhancement in [{sup 3}H]-thymidine uptake in DNA along with increased myeloperoxidase and ornithine decarboxylase activities, suggesting tissue inflammation and cell proliferation. Furthermore, DON (168 nmol) caused enhanced expression of RAS, and phosphorylation of PI3K/Akt, ERK, JNK and p38 MAPKs. DON exposure also showed activation of transcription factors, c-fos, c-jun and NF-κB along with phosphorylation of IkBα. Enhanced phosphorylation of NF-κB by DON caused over expression of target proteins, COX-2, cyclin D1 and iNOS in skin. Though a single topical application of DMBA followed by twice weekly application of DON (84 and 168 nmol) showed no tumorigenesis after 24 weeks, however, histopathological studies suggested hyperplasia of the epidermis and hypertrophy of hair follicles. Interestingly, intestine was also found to be affected as enlarged Peyer's patches were observed, suggesting inflammatory effects which were supported by elevation of inflammatory cytokines after 24 weeks of topical application of DON. These results suggest that DON induced cell proliferation in mouse skin is through the activation of MAPK signaling pathway involving transcription factors NFκB and AP-1, further leading to transcriptional activation of downstream target proteins c-fos, c-jun, cyclin D1, iNOS and COX-2 which might be responsible for its inflammatory potential. - Highlights: • Topical application of DON enhanced epidermal inflammation and cell proliferation. • DON follows PI3K/Akt/MAPK signaling cascade, with activation of AP-1 and NF

  1. WImpiBLAST: web interface for mpiBLAST to help biologists perform large-scale annotation using high performance computing.

    Directory of Open Access Journals (Sweden)

    Parichit Sharma

    Full Text Available The function of a newly sequenced gene can be discovered by determining its sequence homology with known proteins. BLAST is the most extensively used sequence analysis program for sequence similarity search in large databases of sequences. With the advent of next generation sequencing technologies it has now become possible to study genes and their expression at a genome-wide scale through RNA-seq and metagenome sequencing experiments. Functional annotation of all the genes is done by sequence similarity search against multiple protein databases. This annotation task is computationally very intensive and can take days to obtain complete results. The program mpiBLAST, an open-source parallelization of BLAST that achieves superlinear speedup, can be used to accelerate large-scale annotation by using supercomputers and high performance computing (HPC clusters. Although many parallel bioinformatics applications using the Message Passing Interface (MPI are available in the public domain, researchers are reluctant to use them due to lack of expertise in the Linux command line and relevant programming experience. With these limitations, it becomes difficult for biologists to use mpiBLAST for accelerating annotation. No web interface is available in the open-source domain for mpiBLAST. We have developed WImpiBLAST, a user-friendly open-source web interface for parallel BLAST searches. It is implemented in Struts 1.3 using a Java backbone and runs atop the open-source Apache Tomcat Server. WImpiBLAST supports script creation and job submission features and also provides a robust job management interface for system administrators. It combines script creation and modification features with job monitoring and management through the Torque resource manager on a Linux-based HPC cluster. Use case information highlights the acceleration of annotation analysis achieved by using WImpiBLAST. Here, we describe the WImpiBLAST web interface features and architecture

  2. WImpiBLAST: web interface for mpiBLAST to help biologists perform large-scale annotation using high performance computing.

    Science.gov (United States)

    Sharma, Parichit; Mantri, Shrikant S

    2014-01-01

    The function of a newly sequenced gene can be discovered by determining its sequence homology with known proteins. BLAST is the most extensively used sequence analysis program for sequence similarity search in large databases of sequences. With the advent of next generation sequencing technologies it has now become possible to study genes and their expression at a genome-wide scale through RNA-seq and metagenome sequencing experiments. Functional annotation of all the genes is done by sequence similarity search against multiple protein databases. This annotation task is computationally very intensive and can take days to obtain complete results. The program mpiBLAST, an open-source parallelization of BLAST that achieves superlinear speedup, can be used to accelerate large-scale annotation by using supercomputers and high performance computing (HPC) clusters. Although many parallel bioinformatics applications using the Message Passing Interface (MPI) are available in the public domain, researchers are reluctant to use them due to lack of expertise in the Linux command line and relevant programming experience. With these limitations, it becomes difficult for biologists to use mpiBLAST for accelerating annotation. No web interface is available in the open-source domain for mpiBLAST. We have developed WImpiBLAST, a user-friendly open-source web interface for parallel BLAST searches. It is implemented in Struts 1.3 using a Java backbone and runs atop the open-source Apache Tomcat Server. WImpiBLAST supports script creation and job submission features and also provides a robust job management interface for system administrators. It combines script creation and modification features with job monitoring and management through the Torque resource manager on a Linux-based HPC cluster. Use case information highlights the acceleration of annotation analysis achieved by using WImpiBLAST. Here, we describe the WImpiBLAST web interface features and architecture, explain design

  3. Risk Acceptance Personality Paradigm: How We View What We Don't Know We Don't Know

    Science.gov (United States)

    Massie, Michael J.; Morris, A. Terry

    2011-01-01

    The purpose of integrated hazard analyses, probabilistic risk assessments, failure modes and effects analyses, fault trees and many other similar tools is to give managers of a program some idea of the risks associated with their program. All risk tools establish a set of undesired events and then try to evaluate the risk to the program by assessing the severity of the undesired event and the likelihood of that event occurring. Some tools provide qualitative results, some provide quantitative results and some do both. However, in the end the program manager and his/her team must decide which risks are acceptable and which are not. Even with a wide array of analysis tools available, risk acceptance is often a controversial and difficult decision making process. And yet, today's space exploration programs are moving toward more risk based design approaches. Thus, risk identification and good risk assessment is becoming even more vital to the engineering development process. This paper explores how known and unknown information influences risk-based decisions by looking at how the various parts of our personalities are affected by what they know and what they don't know. This paper then offers some criteria for consideration when making risk-based decisions.

  4. Autophagy protects intestinal epithelial cells against deoxynivalenol toxicity by alleviating oxidative stress via IKK signaling pathway.

    Science.gov (United States)

    Tang, Yulong; Li, Jianjun; Li, Fengna; Hu, Chien-An A; Liao, Peng; Tan, Kunrong; Tan, Bie; Xiong, Xia; Liu, Gang; Li, Tiejun; Yin, Yulong

    2015-12-01

    Autophagy is an intracellular process of homeostatic degradation that promotes cell survival under various stressors. Deoxynivalenol (DON), a fungal toxin, often causes diarrhea and disturbs the homeostasis of the intestinal system. To investigate the function of intestinal autophagy in response to DON and associated mechanisms, we firstly knocked out ATG5 (autophagy-related gene 5) in porcine intestinal epithelial cells (IPEC-J2) using CRISPR-Cas9 technology. When treated with DON, autophagy was induced in IPEC-J2 cells but not in IPEC-J2.Atg5ko cells. The deficiency in autophagy increased DON-induced apoptosis in IPEC-J2.atg5ko cells, in part, through the generation of reactive oxygen species (ROS). The cellular stress response can be restored in IPEC-J2.atg5ko cells by overexpressing proteins involved in protein folding. Interestingly, we found that autophagy deficiency downregulated the expression of endoplasmic reticulum folding proteins BiP and PDI when IPEC-J2.atg5ko cells were treated with DON. In addition, we investigated the molecular mechanism of autophagy involved in the IKK, AMPK, and mTOR signaling pathway and found that Bay-117082 and Compound C, specific inhibitors for IKK and AMPK, respectively, inhibited the induction of autophagy. Taken together, our results suggest that autophagy is pivotal for protection against DON in pig intestinal cells. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. The Authors of the Ingenious Hidalgo Don Quixote of La Mancha

    Directory of Open Access Journals (Sweden)

    Branka Kalenić Ramšak

    2008-12-01

    Full Text Available Even today literary criticism still considers the novel Don Quixote the first modern European novel because it fundamentally changes both the concept of literary creation and the findings regarding literary reception. Miguel de Cervantes Saavedra published the first part of his chivalric novel in 1605 in Madrid with the title El ingenioso hidalgo don Quijote de la Mancha. He published the second part, titled El ingenioso caballero don Quijote de la Mancha, ten years later (i.e., in 1615, again in Madrid. Why did Cervantes change the title in the second part of his novel and thus transform Don Quixote the hidalgo ‘nobleman’ into Don Quixote the caballero ‘knight, nobleman, horseman’? In Spanish literature of Cervantes’ time, writers often borrowed texts from one another, wrote sequels to them, and reworked them into humorous poems, jocular one-act plays, or unusual parodies. The Baroque concept of imitation was not understood as plagiarism, but rather as a positive approach to creativity. One of Cervantes’ most enthusiastic imitators was Alonso Fernández de Avellaneda. He hated Cervantes, but loved Don Quixote so much that he wrote a sequel to it in the form of a chivalric novel. In 1614, Avellaneda published his novel titled Segundo tomo del ingenioso hidalgo don Quijote de la Mancha (The Second Part of the Ingenious Hidalgo of La Mancha in Tarragona. Who is hidden behind the name Alonso Fernández de Avellaneda? To date, literary history has not been able to establish with certainty who the author of this “second part” was; this work represents the greatest literary mystery of all time in Spanish literature. In the 1960s a theory developed among Cervantes experts that for now seems to be the most convincing in determining Avellaneda’s true identity. In his article “ El Quijote y los libros” (Don Quixote and Books of 1969, Martín de Riquer presented the first well-founded hypothesis claiming that the writer Alonso Fern

  6. Dissolved organic nitrogen (DON) profile during backwashing cycle of drinking water biofiltration.

    Science.gov (United States)

    Liu, Bing; Gu, Li; Yu, Xin; Yu, Guozhong; Zhang, Huining; Xu, Jinli

    2012-01-01

    A comprehensive investigation was made in this study on the variation of dissolved organic nitrogen (DON) during a whole backwashing cycle of the biofiltration for drinking water treatment. In such a cycle, the normalized DON concentration (C(effluent)/C(influent)) was decreased from 0.98 to 0.90 in the first 1.5h, and then gradually increased to about 1.5 in the following 8h. Finally, it remained stable until the end of this 24-hour cycle. This clearly 3-stage profile of DON could be explained by three aspects as follows: (1) the impact of the backwashing on the biomass and the microbial activity; (2) the release of soluble microbial products (SMPs) during the biofiltration; (3) the competition between heterotrophic bacteria and nitrifying bacteria. All the facts supported that more DON was generated during later part of the backwashing cycle. The significance of the conclusion is that the shorter backwashing intervals between backwashing for the drinking water biofilter should further decrease the DON concentration in effluent of biofilter. Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

  7. Chronic DON exposure and acute LPS challenge: effects on porcine liver morphology and function.

    Science.gov (United States)

    Renner, Lydia; Kahlert, Stefan; Tesch, Tanja; Bannert, Erik; Frahm, Jana; Barta-Böszörményi, Anikó; Kluess, Jeannette; Kersten, Susanne; Schönfeld, Peter; Rothkötter, Hermann-Josef; Dänicke, Sven

    2017-08-01

    The aim of the present study was to examine the role of chronic deoxynivalenol (DON) exposition on the liver morphology and function in combination with pre- and post-hepatic lipopolysaccharide (LPS) stress in young pigs fed for 4 weeks with a DON-contaminated diet (4.59 mg/kg feed). At the end of the experiment, LPS (7.5 μg/kg BW) was administered for 1 h pre-hepatically (Vena portae hepatis) or post-hepatically (Vena jugularis). Liver morphology was macroscopically checked and showed haemorrhage in all LPS groups, significantly higher relative liver weights, accompanied by marked oedema in the gallbladder wall. Histological changes were judged by a modified histology activity index (HAI). Liver HAI score was significantly increased in all LPS groups compared to placebo, primarily due to neutrophil infiltration and haemorrhage. DON feed alone was without effect on the liver HAI. Liver function was characterized by (i) hepatic biochemical markers, (ii) mitochondrial respiration and (iii) Ca 2+ accumulation capacity of isolated mitochondria. Clinical chemical parameters characterizing liver function were initially (liver mitochondria was not impaired by chronic DON exposure, acute LPS challenge or combined treatments. DON-contaminated feed did not change macroscopy and histology of the liver, but modified the function under LPS stress. The different function was not linked to modifications of liver mitochondria.

  8. Consumption as Sign in Don DeLillo’s Cosmopolis

    Directory of Open Access Journals (Sweden)

    Seyyede Fateme Mirbabazade

    2013-11-01

    Full Text Available As one of the foremost American postmodern authors, Don DeLillo tends to focus on construction of postmodern subject’s consciousness through media, technology and consumption. Nevertheless, despite many affinities between Baudrillard and DeLillo, many researches which have been done on his works have failed to theoretically analyze them from Baudrillardian perspective. Although there is affinity between Baudrillard and DeLillo, there is dissimilarity as well. While Baudrillard believes that that there is no escape for individual from the ideology of the system, DeLillo claims that there is hope for change and revolution for the individuals by their action in society, particularly by the means of art, to be more  than a cog in the machine of ideology of system. Baudrillard, as one of the most influential postmodern theorists, defines consumption as organized control of sign and one of the many ways any subject is assimilated in any given society. For Baudrillard the logic of consumption is based on social differentiation. By the logic of social differentiation, individuals distinguish themselves and obtain social prestige and standing through the purchase and use of consumer goods. In his theorization about the concept of need and value, Baudrillard finds Marx’s logics of use value (utility and functionality and exchange value (economic value inadequate to include the whole function of an object and adds the logic of sign value. Baudrillard asserts that in consumption economic exchange value (money is transformed into sign exchange value (prestige, etc.; yet this functioning is maintained by the use value. The only way out of this dilemma, Baudrillard claims, is to return to symbolic exchange which is neither a conception nor an agency, but an act of exchange and a social relation and the only approach to real human communication and understanding. Therefore this research attempts to highlights those affinities in DeLillo’s first post-9

  9. Early events induced by the toxin deoxynivalenol lead to programmed cell death in Nicotiana tabacum cells.

    Science.gov (United States)

    Yekkour, Amine; Tran, Daniel; Arbelet-Bonnin, Delphine; Briand, Joël; Mathieu, Florence; Lebrihi, Ahmed; Errakhi, Rafik; Sabaou, Nasserdine; Bouteau, François

    2015-09-01

    Deoxynivalenol (DON) is a mycotoxin affecting animals and plants. This toxin synthesized by Fusarium culmorum and Fusarium graminearum is currently believed to play a decisive role in the fungal phytopathogenesis as a virulence factor. Using cultured cells of Nicotiana tabacum BY2, we showed that DON-induced programmed cell death (PCD) could require transcription and translation processes, in contrast to what was observed in animal cells. DON could induce different cross-linked pathways involving (i) reactive oxygen species (ROS) generation linked, at least partly, to a mitochondrial dysfunction and a transcriptional down-regulation of the alternative oxidase (Aox1) gene and (ii) regulation of ion channel activities participating in cell shrinkage, to achieve PCD. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Don Quixote and Roque Guinart against the way of life of the influential people

    Directory of Open Access Journals (Sweden)

    Isabel M. Roger

    2016-11-01

    Full Text Available The apocryphal Second part of don Quixote altered many of the purposes of Cervantes. He changed the destination of his hero. As observed by don Quixote when visiting a printinghouse, its publication took place in Barcelona. The author gave prominence to a town as in picaresque novels. However, he did not modify his attitude towards the behaviour of the influential people, in keeping with Erasmus’ concept of stupidity. Surely, Cervantes reaffirmed his approach to the golden age through the presence of Roque Guinart, the only historical character who appears in the novel. This paper examines how the influential people behave in front of don Quixote, and how his performance is similar to that of Roque Guinart.

  11. Loca amoena in Don Quixote. The art of transition in pastoral episodes

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Márquez

    2016-11-01

    Full Text Available Don Quixote’s pastoral episodes allow us to analyze Cervantes’s subtleness and irony in the art of transition. Cervantes intentionally uses the locus amoenus as a topos to link the pastoral episodes with the comic realistic story of Don Quixote and Sancho. The most striking feature of these meticulous transitions is that the locus amoenus, which would correspond to the pastoral stories, is transferred to the primary diegetic level, replacing the hegemonic chronotopos of the camino real. The role of this technique is to smooth the transition to the bucolic world. Moreover, this analysis helps us interpret the pastoral events as a tragic counterpoint (Marcela and Chrysostom, Leandra, and to perceive Don Quixote’s siesta (the “feigned Arcadia” as the starting point of his decline.

  12. Pemodelan Enterprise Architecture Sistem Informasi Akademik SMA PL Don Bosko Semarang Dengan Framework Zachman

    Directory of Open Access Journals (Sweden)

    Maria Alfonsa Chintia Dea Prananingrum

    2017-05-01

    Full Text Available Abstrak SMA PL Don Bosko Semarang belum dapat memanfaatkan teknologi komputer secara optimal karena masih menggunakan cara manual dalam pengelolaan berbagai macam data akademik sehingga memberikan masalah seperti lambatnya dalam pembuatan laporan yang menyulitkan kepala sekolah dalam pengambilan keputusan. Oleh sebab itu, SMA PL Don Bosko Semarang membutuhkan Sistem Informasi Akademik untuk memberikan kemudahan dalam mengelola berbagai macam data akademik secara terintegrasi serta memberikan layanan yang lebih baik kepada siswanya. Sebuah model architecture enterprise Sistem Informasi Akademik dibutuhkan agar meminimalisir kegagalan ketika menerapkan sistem tersebut sekaligus dapat berjalan sesuai kebutuhan di SMA PL Don Bosko Semarang. Metode analisis dalam penelitian ini menggunakan Framework Zachman yang memberikan pondasi dalam membantu menyediakan struktur dasar organisasi sehingga dapat mendukung perancangan dan pengembangan sistem informasi suatu organisasi. Hasil dari penelitian ini berupa blueprint (cetak biru pemodelan Sistem Informasi Akademik. Kata kunci— sistem informasi akademik, architecture enterprise, framework zachman, bluprint

  13. Co-Contamination of DON and NIV in Domestic Flour in Japan: Survey, Intake, Reduction and Rapid Assay

    Science.gov (United States)

    Nivalenol (NIV) and Deoxynivalenol (DON) are trichothecene mycotoxins produced by Fusarium spp. that contaminate mainly cereal crops, such as wheat, barley, and maize. These mycotoxins are serious health hazards to humans and domestic animals. In Japan, there have been many reports of DON and NIV ...

  14. RICKETS AT THE MEDICI COURT OF FLORENCE: THE CASE OF DON FILIPPINO (1577-1582).

    Science.gov (United States)

    Castagna, Maura; Giuffra, Valentina; Fattori, Silvia; Vitiello, Angelica; Caramella, Davide; Giustini, Davide; Fornaciari, Gino

    2014-01-01

    Among the children found in the crypt of the Grand Duke Giangastone in S. Lorenzo Basilica (Florence), the skeletal remains of a 5-year-old child still wearing his fine high social status clothing were recovered. This child of the Medici family was identified as Don Filippino (1577-1582), son of the Grand Duke Francesco I (1541-1587) and Giovanna from Austria (1547 - 1578). The prince showed several pathological deformities of the cranial and post-cranial skeleton, including enlargement of the cranium, thinning of the cranial vault bones (craniotabes), platybasia and marked bending of femora, tibiae and fibulae. Differential diagnosis suggests that Don Filippino was affected by rickets. The occurrence of this metabolic disease related to vitamin D deficiency in a Renaissance high social class individual can be explained by the practice of very prolonged breast-feeding, up until two years of age. Maternal milk contains insufficient vitamin D ratios and retarded weaning severely exposes children to a higher risk of developing rickets, especially if dietary habits are combined with inadequate exposure to sunlight. Historical sources describe Don Filippino as frail and sickly, with frequent illnesses and persistent slight fevers, and it can be supposed that the child was frequently confined indoors, especially in the cold season. Integration of osteoarchaeological evidence with historical documentation suggests that bone lesions observed in the skeletal remains of Don Filippino are compatible with a diagnosis of rickets, caused by the custom of prolonged breast-feeding associated with inadequate sunlight exposure to sunlight. Historical sources describe Don Filippino as frail and sickly, with frequent illnesses and persistent slight fevers, and it can be supposed that the child was frequently confined indoors, especially in the cold season. Integration of osteoarchaeological evidence with historical documentation suggests that bone lesions observed in the skeletal

  15. The Discovery of Cometary Activity in Near-Earth Asteroid (3552) Don Quixote

    Science.gov (United States)

    Mommert, Michael; Hora, Joseph L.; Harris, Alan W.; Reach, William T.; Emery, Joshua P.; Thomas, Cristina A.; Mueller, Michael; Cruikshank, Dale P.; Trilling, David E.; Delbo, Marco; Smith, Howard A.

    2014-01-01

    The near-Earth object (NEO) population, which mainly consists of fragments from collisions between asteroids in the main asteroid belt, is thought to include contributions from short-period comets as well. One of the most promising NEO candidates for a cometary origin is near-Earth asteroid (3552) Don Quixote, which has never been reported to show activity. Here we present the discovery of cometary activity in Don Quixote based on thermal-infrared observations made with the Spitzer Space Telescope in its 3.6 and 4.5 μm bands. Our observations clearly show the presence of a coma and a tail in the 4.5 μm but not in the 3.6 μm band, which is consistent with molecular band emission from CO2. Thermal modeling of the combined photometric data on Don Quixote reveals a diameter of 18.4_{-0.4}^{+0.3} km and an albedo of 0.03^{+0.02}_{-0.01}, which confirms Don Quixote to be the third-largest known NEO. We derive an upper limit on the dust production rate of 1.9 kg s-1 and derive a CO2 gas production rate of (1.1 ± 0.1) × 1026 molecules s-1. Spitzer Infrared Spectrograph spectroscopic observations indicate the presence of fine-grained silicates, perhaps pyroxene rich, on the surface of Don Quixote. Our discovery suggests that CO2 can be present in near-Earth space over a long time. The presence of CO2 might also explain that Don Quixote's cometary nature remained hidden for nearly three decades.

  16. The discovery of cometary activity in near-Earth asteroid (3552) Don Quixote

    Energy Technology Data Exchange (ETDEWEB)

    Mommert, Michael; Harris, Alan W. [Institute of Planetary Research, German Aerospace Center (DLR), Rutherfordstr. 2, D-12489 Berlin (Germany); Hora, Joseph L.; Smith, Howard A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138-1516 (United States); Reach, William T. [Universities Space Research Association, Stratospheric Observatory for Infrared Astronomy, MS 232-11, NASA Ames Research Center, Moffett Field, CA 94035 (United States); Emery, Joshua P. [Department of Earth and Planetary Sciences, University of Tennessee, 1412 Circle Dr., Knoxville, TN 37996 (United States); Thomas, Cristina A. [NASA Postdoctoral Program Fellow, NASA Goddard Space Flight Center, 8800 Greenbelt Rd, Greenbelt, MD 20771 (United States); Mueller, Michael [SRON Netherlands Institute for Space Research, Postbus 800, 9700 AV Groningen (Netherlands); Cruikshank, Dale P. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Trilling, David E. [Department of Physics and Astronomy, Northern Arizona University, P.O. Box 6010, Flagstaff, AZ 86011 (United States); Delbo, Marco [UNS-CNRS-Observatoire de la Cote d' Azur, BP4229, F-06304 Nice Cedex 4 (France)

    2014-01-20

    The near-Earth object (NEO) population, which mainly consists of fragments from collisions between asteroids in the main asteroid belt, is thought to include contributions from short-period comets as well. One of the most promising NEO candidates for a cometary origin is near-Earth asteroid (3552) Don Quixote, which has never been reported to show activity. Here we present the discovery of cometary activity in Don Quixote based on thermal-infrared observations made with the Spitzer Space Telescope in its 3.6 and 4.5 μm bands. Our observations clearly show the presence of a coma and a tail in the 4.5 μm but not in the 3.6 μm band, which is consistent with molecular band emission from CO{sub 2}. Thermal modeling of the combined photometric data on Don Quixote reveals a diameter of 18.4{sub −0.4}{sup +0.3} km and an albedo of 0.03{sub −0.01}{sup +0.02}, which confirms Don Quixote to be the third-largest known NEO. We derive an upper limit on the dust production rate of 1.9 kg s{sup –1} and derive a CO{sub 2} gas production rate of (1.1 ± 0.1) × 10{sup 26} molecules s{sup –1}. Spitzer Infrared Spectrograph spectroscopic observations indicate the presence of fine-grained silicates, perhaps pyroxene rich, on the surface of Don Quixote. Our discovery suggests that CO{sub 2} can be present in near-Earth space over a long time. The presence of CO{sub 2} might also explain that Don Quixote's cometary nature remained hidden for nearly three decades.

  17. The discovery of cometary activity in near-Earth asteroid (3552) Don Quixote

    International Nuclear Information System (INIS)

    Mommert, Michael; Harris, Alan W.; Hora, Joseph L.; Smith, Howard A.; Reach, William T.; Emery, Joshua P.; Thomas, Cristina A.; Mueller, Michael; Cruikshank, Dale P.; Trilling, David E.; Delbo, Marco

    2014-01-01

    The near-Earth object (NEO) population, which mainly consists of fragments from collisions between asteroids in the main asteroid belt, is thought to include contributions from short-period comets as well. One of the most promising NEO candidates for a cometary origin is near-Earth asteroid (3552) Don Quixote, which has never been reported to show activity. Here we present the discovery of cometary activity in Don Quixote based on thermal-infrared observations made with the Spitzer Space Telescope in its 3.6 and 4.5 μm bands. Our observations clearly show the presence of a coma and a tail in the 4.5 μm but not in the 3.6 μm band, which is consistent with molecular band emission from CO 2 . Thermal modeling of the combined photometric data on Don Quixote reveals a diameter of 18.4 −0.4 +0.3 km and an albedo of 0.03 −0.01 +0.02 , which confirms Don Quixote to be the third-largest known NEO. We derive an upper limit on the dust production rate of 1.9 kg s –1 and derive a CO 2 gas production rate of (1.1 ± 0.1) × 10 26 molecules s –1 . Spitzer Infrared Spectrograph spectroscopic observations indicate the presence of fine-grained silicates, perhaps pyroxene rich, on the surface of Don Quixote. Our discovery suggests that CO 2 can be present in near-Earth space over a long time. The presence of CO 2 might also explain that Don Quixote's cometary nature remained hidden for nearly three decades.

  18. Organ damage and hepatic lipid accumulation in carp (Cyprinus carpio L.) after feed-borne exposure to the mycotoxin, deoxynivalenol (DON).

    Science.gov (United States)

    Pietsch, Constanze; Schulz, Carsten; Rovira, Pere; Kloas, Werner; Burkhardt-Holm, Patricia

    2014-02-21

    Deoxynivalenol (DON) frequently contaminates animal feed, including fish feed used in aquaculture. This study intends to further investigate the effects of DON on carp (Cyprinus carpio L.) at concentrations representative for commercial fish feeds. Experimental feeding with 352, 619 or 953 μg DON kg(-1) feed resulted in unaltered growth performance of fish during six weeks of experimentation, but increased lipid peroxidation was observed in liver, head kidney and spleen after feeding of fish with the highest DON concentration. These effects of DON were mostly reversible by two weeks of feeding the uncontaminated control diet. Histopathological scoring revealed increased liver damage in DON-treated fish, which persisted even after the recovery phase. At the highest DON concentration, significantly more fat, and consequently, increased energy content, was found in whole fish body homogenates. This suggests that DON affects nutrient metabolism in carp. Changes of lactate dehydrogenase (LDH) activity in kidneys and muscle and high lactate levels in serum indicate an effect of DON on anaerobic metabolism. Serum albumin was reduced by feeding the medium and a high dosage of DON, probably due to the ribotoxic action of DON. Thus, the present study provides evidence of the effects of DON on liver function and metabolism.

  19. Organ Damage and Hepatic Lipid Accumulation in Carp (Cyprinus carpio L. after Feed-Borne Exposure to the Mycotoxin, Deoxynivalenol (DON

    Directory of Open Access Journals (Sweden)

    Constanze Pietsch

    2014-02-01

    Full Text Available Deoxynivalenol (DON frequently contaminates animal feed, including fish feed used in aquaculture. This study intends to further investigate the effects of DON on carp (Cyprinus carpio L. at concentrations representative for commercial fish feeds. Experimental feeding with 352, 619 or 953 μg DON kg−1 feed resulted in unaltered growth performance of fish during six weeks of experimentation, but increased lipid peroxidation was observed in liver, head kidney and spleen after feeding of fish with the highest DON concentration. These effects of DON were mostly reversible by two weeks of feeding the uncontaminated control diet. Histopathological scoring revealed increased liver damage in DON-treated fish, which persisted even after the recovery phase. At the highest DON concentration, significantly more fat, and consequently, increased energy content, was found in whole fish body homogenates. This suggests that DON affects nutrient metabolism in carp. Changes of lactate dehydrogenase (LDH activity in kidneys and muscle and high lactate levels in serum indicate an effect of DON on anaerobic metabolism. Serum albumin was reduced by feeding the medium and a high dosage of DON, probably due to the ribotoxic action of DON. Thus, the present study provides evidence of the effects of DON on liver function and metabolism.

  20. Don Kişot ve Daniş Çelebi Don Kişot And Daniş Çelebi

    Directory of Open Access Journals (Sweden)

    Canan OLPAK KOÇ

    2013-07-01

    Full Text Available Although novel is mostly depend on fiction, it is one of the writtensources and withnesses for people who are trying history of human andgoods. It is submit itself to people in a different ways in the past. But wewant to talk abount modern novel here. For modern it is admit that donQuixote is the inception of novel. In this sense it is definitely anticipatedto be something from Don Quixote in every heros of novels. Also thiseffect in Turkish literature begins to seen as a species. The are which istalking about the effect of Don Quixote is seen at piece of Ahmet mithatEfendi who is undertake social tasks as written machine.Cervantes and Ahmet Mithat Efendi are the two importantnovelists in the world literature. Because both authors used their pensfor art and community servise. In this study these two authors will becompared with the character Don Quixote that meets them in common.In this comparison the novel of Cervante's Don Quixote and the novel ofAhmet Mithat efendi's Don Quixote in İstanbul will be summarized andthe main charactors of each one will be compared exactly witheachother. In this comparison our aim is not only using same types butalso how the writers avaluate their social lives. Before giving it, firstly itwill be montioned the process of known of the novel in Turkishliterature. Roman, çoğunlukla her ne kadar kurguya dayanıyor olsa da eşyanın ve insanın tarihini yazmaya kalkışanlar için önemli yazılı kaynaklardan, tanıklardan biridir. Geçmişte farklı şekiller içinde okura kendini takdim etmiştir. Ancak biz burada modern romandan bahsetmek istiyoruz. Modern anlamda romanın başlangıcı Don Kişot olarak kabul edilir. Bu anlamda sonraki devirlerin her romanında Cervantes’ten, her roman kahramanında da Don Kişot’tan mutlaka bir şeylerin olması beklenir. Türk edebiyatında da bu etki romanın bir tür olarak girmesi ile görülmeye başlar. Bahsedilen dönemde bu Don Kişot etkisi bir yazı makinesi

  1. Toward Complete Inclusion: Lesbian, Gay, Bisexual, and Transgender Military Service Members after Repeal of Don't Ask, Don't Tell.

    Science.gov (United States)

    Aford, Brandon; Lee, Shawna J

    2016-07-01

    The 2010 repeal of Don't Ask, Don't Tell (DADT) is one example of how U.S. public policy has shifted toward greater inclusion of lesbian, gay, and bisexual (LGB) individuals. The repeal of DADT reversed the practice of discharging LGB service members on the basis of sexual identity. LGB service members may now serve their country without fear of direct repercussions stemming from sexual identity. Though it is a statutory step toward parity, DADT repeal does not address a number of cultural and institutional inequities that continue to hinder full inclusion of sexual minority service members. Notably, as discussed in this article, DADT largely ignores issues facing the transgender population. This study examines remaining inequities and their ramifications for lesbian, gay, bisexual, and transgender service members and their families. The article concludes with practice and policy recommendations for culturally competent social work practice with military service members across the sexual identity spectrum.

  2. Un curioso coleccionista del siglo XVII: don Manuel de Porras

    Directory of Open Access Journals (Sweden)

    Agulló y Cobo, Mercedes

    2003-09-01

    Full Text Available Art collecting - an avocation almost exclusive to royalty in Spain - has not had representatives among those who did not belong to the high nobility, not even among artists themselves. In many cases, the word "collection" has been applied to what in reality were mere lists of patrimonial properties. For all of the above, it is especially noteworthy to encounter someone who neither belonged to an elevated class nor was a painter, but who managed to unite, at great personal sacrifice, an important art collection. Manuel de Porras owned interesting and a relatively large number of paintings, sculptures and prints, some of them extremely valuable. As a good collector, in order to avoid the dispersion of these works, he donated them to the Shod Trinitarians in Madrid and the Oratory of Saint Philip Neri in Alcalá, but unfortunately, in spite of his good intentions, nothing has survived.

    El coleccionismo —afición casi exclusiva de Reyes en España— no ha tenido representantes entre personas que no pertenecieran a la alta nobleza, ni entre los propios artistas. En muchos casos lo que se ha venido llamando colecciones son sólo relación de bienes patrimoniales. Por ello, resulta más llamativo encontrar alguien que, sin pertenecer a una clase elevada ni ser artista, lograra reunir —aun a costa de grandes sacrificios que le llevaron al extremo de ser enterrado de limosna— una tan importante colección de obras de arte como el personaje objeto de este artículo: Manuel de Porras, quien contaba con un interesante y elevado (para un particular sin títulos número de pinturas y esculturas, y un importantísimo número de dibujos y estampas, algunas valiosísimas y de alto precio. Desgraciadamente, aunque lo donó —como buen coleccionista, para evitar su dispersión— a los Trinitarios calzados de Madrid y al Oratorio de San Felipe Neri de Alcalá, nada de ello ha llegado a nuestros días.

  3. La reciprocidad y el don no son la misma cosa

    Directory of Open Access Journals (Sweden)

    Ricardo Gabriel Abduca

    2007-12-01

    Full Text Available El autor se propone mostrar por qué la noción de reciprocidad, aunque ha sido muchas veces tomada como sinónimo del fenómeno de intercambios de dones, corresponde a diversas situaciones sociales, por lo cual tiene poca utilidad descriptiva y explicativa. Examina algunos hitos de la historia antropológica, mostrando que más que un concepto, 'reciprocidad' es un palimpsesto sobre el cual, de Durkheim a Polanyi, se han ido escribiendo variadas nociones. En cambio, sugiere una definición de don más estricta, cercana a las ideas de Mauss y acorde con los avances de la etnografía y la teoría contemporánea. Sugiere distinguir entre circuitos cerrados de dones, donde circulan bienes de consumo final, y circuitos abiertos, donde los dones que circulan condensan el conjunto de las relaciones sociales.O objetivo deste texto é mostrar que a expressão 'reciprocidade', ainda foi considerada como sinônimo de 'câmbio de domes', é outra coisa. O autor sugere um breve esquema de alguns marcos do desenvolvimento da noção de 'reciprocidade' em a teoria antropológica, mostrando que o sentido dela expressão foi mudando até assemelhar um palimpsesto com múltiplas rescritas, no processo que vá de Durkheim a Polanyi. Defende um conceito de dom próximo às idéias de Mauss e a certos avances dela etnografia contemporânea e a teoria social. Distingue deus tipos de circuitos de circulação de domes: fechados, onde circulam bens de consumação direita, e apertos, onde circulam certo tipo de bens que condensam o conjunto das relações sociais.The aim of this text is to show how the notion of 'reciprocity', although have been considered a synonymous of gift exchange, veils different social situations. A brief survey of the history of the use of the word shows how 'reciprocity', from Durkheim to Polanyi, seems as a palimpsest of various notions. Although, he essays a defense of a concept of 'gift' related to the Maussian texts, and closer to some

  4. Studies on cytological, physiological and genetic characteristics in somatic mutant strains of Sugi (Cryptomeria japonica D. Don)

    International Nuclear Information System (INIS)

    Maeta, T.; Somegou, M.; Nakahira, K.; Miyazaki, Y.; Kondo, T.

    1982-01-01

    From microscopic observation of the pollen of induced mutant strains in Sugi (Cryptomeria japonica D. Don), it was found that there were large differences in pollen fertility among the mutant strains, and that it deviated year to year from the mother plants. The large differences in frequency of sterile pollen among mutant strains depended on the genetic characteristics of each mutant strain. Higher frequencies of sterile pollen were observed at the terminal part of branchlets in some mutant strains, and this was considered to be induced by the lateness of flower-bud formation at low temperature conditions in late summer. Delayed formation and gibberellic acid treatment applied for flower induction resulted in low fertility and abnormality of pollen in mutant strains. Chromosome aberration in mutant strains was caused either by gamma irradiation or by some mutational events that responded to environmental conditions. In the former case, aberration might have been maintained for a long period through vegetative propagation. Some of the irregularities were due to mitotic cell division, because cells with micronuclei at the pacytene stage in pollen mother cells and with fragments at MI were observed. Somatic mutability of Kuma-sugi mutants after re-irradiation was investigated. From waxless mutants morphological somatic mutations, which have fat or stout stems and thick and short needles, were frequently produced, whereas from morphological mutants the lowest somatic mutation frequency was induced. In some mutant strains higher rooting ability than the mother plants was found, and the possibility of character improvement was pointed out. (author)

  5. Dr. S. Donald (Don Stookey: (1915-2014: Pioneering Researcher and Adventurer

    Directory of Open Access Journals (Sweden)

    George Halsey Beall

    2016-08-01

    Full Text Available Don Stookey was a special person by any measure: an unassuming optimist, eminent scientist and inventor, adventurer, and a beloved family man. Don Stookey, the father of glass-ceramics, was a pioneer in inducing and understanding internal nucleation phenomena in glass. His early work on dense opal glasses and photosensitive precipitation of gold and silver in glass led to an amazing series of inventions: Fotalite®, a photosensitive opal, chemically machined Fotoform® and Fotoceram®, and TiO2-nucleated Pyroceram™ products including missile nosecones and oven-proof cookware. He received a basic patent on glass-ceramics which was contested and affirmed in court.Don was able to demonstrate a clear photochromic glass that showed reversible darkening for thousands of cycles. This material became a fixture in the ophthalmic industry. He went on to invent a full-color polychromatic glass capable of yielding a permanent patterned and monolithic stained glass.In his life outside science, Don chaired an interfaith group that founded a home for the elderly in Corning. He was also a wilderness enthusiast, surviving a plane crash in the Arctic and two boat capsizings. Even In his later years, he continued fishing off the coast of Florida and on Lake Ontario, and went solo on a trip to the Patagonian Andes.

  6. Why I don't kill myself : [poems] / Paul-Eerik Rummo

    Index Scriptorium Estoniae

    Rummo, Paul-Eerik, 1942-

    2003-01-01

    Autori lühitutvustus lk. 262. Sisu: Why I don't kill myself ; The sky stoops over the earth ; Clinging ; Crooning. Orig.: Miks ma end ära ei tapa ; "Taevas on kummargil üle maa..." ; Kinni hoidmas ; Poolüminal

  7. [Study of some characteristics of morphogenesis and germination of Pinus pallasiana D. Don. pollen].

    Science.gov (United States)

    Koba, V P

    2004-01-01

    Investigation of Pinus pallasiana D. Don. pollen morphogenesis in natural forest plantations of the southern slope of the Main ridge of Crimean mountains has been carried out. Some abnormalities of pollen grain and pollen tube formation in the course of pollen germination in vitro are described. The dynamics of developmental abnormalities of P. allasiana male gametophyte is characterized.

  8. "Don't[strikethrough] Talk with Strangers" Engaging Student Artists in Dialogic Artmaking

    Science.gov (United States)

    Collins, Kate

    2015-01-01

    Starting with a brief description of the culminating participatory arts and dialogue event, "Don't[strikethrough] Talk With Strangers," the author then backtracks to describe the rationale and process for a new community engaged arts course centred on dialogic artmaking. The course was designed for undergraduate and youth artists with…

  9. Variable Input: What Sarah Reveals about Nonagreeing "Don't" and Theories of Root Infinitives

    Science.gov (United States)

    Miller, Karen

    2013-01-01

    Two recent proposals link the use of nonagreeing "don't" to the Root Infinitive (RI) Stage. Guasti & Rizzi (2002) argue for a misset parameter involving how agreement is spelled out. Schütze (2010) proposes that Infl is underspecified in child language and that "do" surfaces to support the contracted clitic/affix…

  10. Department of the Navy (DON) Additive Manufacturing (AM) Implementation Plan V2.0 (2017)

    Science.gov (United States)

    2017-05-04

    widespread AM implementation. While there is industry and academia investment in the digital manufacturing/AM renaissance , the Naval Research and...alignment of supporting science and technology (S&T), research and development (R&D), acquisition, logistics and business process investments to meet DON...R&D, Acquisition, Operational, Business, and Sustainment communities, plus investing and leveraging Science , Technology, Engineering, and

  11. What Most Women Don't Know About P.A.D.

    Science.gov (United States)

    ... Issues What Most Women Don't Know About P.A.D. Past Issues / Summer 2009 Table of Contents For ... Heart Disease www.womenheart.org Risk Factors for P.A.D. Some conditions and habits raise your chance of ...

  12. Occurrence of Deoxynivalenol (DON in wheat flours in Guilan Province, northern Iran

    Directory of Open Access Journals (Sweden)

    Reza Kazemi Darsanaki

    2015-02-01

    According to results obtained, incidence and contamination levels of DON, seem to be a serious problem for public health. Therefore, cereal and cereal based foods should be controlled for the presence of toxins, storage conditions and moisture content, which is considered a major factor in the growth of the Fusarium fungi.

  13. Therapists' continuations following I don't know-responses of adolescents in psychotherapy

    NARCIS (Netherlands)

    Jager, Margot; Huiskes, Mike; Metselaar, Janneke; Knorth, Erik J; De Winter, Andrea F; Reijneveld, Sijmen A

    2016-01-01

    OBJECTIVE: In psychotherapy clients' I don't know-responses (IDK-responses) to therapists' questions are typically considered to be non-cooperating behaviors. How therapists actually handle these behaviors remains unclear. This study therefore aims to assess client-therapist interactions following

  14. Aspectos literarios de la obra de don Joan de Castellanos : Capitulo VIII

    Directory of Open Access Journals (Sweden)

    Mario Germán Romero

    1966-03-01

    Full Text Available Capítulo VIII. Los discursos de Jiménez de Quesada. Toda historia de la literatura colombiana comienza con el nombre del licenciado don Gonzalo Jiménez de Quesada. Que era un letrado, no puede ponerse en duda. Los escritos que de él conocemos justifican plenamente el título.

  15. A revision of Beaumontia Wallich, Kibatalia G. Don and Vallariopsis Woodson (Apocynaceae)

    NARCIS (Netherlands)

    Rudjiman,

    1987-01-01

    This publication is a taxonomic revision on monographic basis of the three Apocynaceae genera Beaumontia Wallich, Kibatalia G. Don and Vallariopsis Woodson (tribe Nerieae of the Apocynoideae). For this revision material from 43

  16. The effects of Catharanthus roseus (l) g. don 1838 aqueous leaf ...

    African Journals Online (AJOL)

    Plant and phytochemical products continue to play an important role in medicine. In this study, the toxicological potentials of the aqueous leaf extract of Catharanthus roseus G. Don 1838 in rabbits were determined. The rabbits were placed in three groups with four rabbits in each group. The control group, a second group ...

  17. Rap Music in School Counseling Based on Don Elligan's Rap Therapy

    Science.gov (United States)

    Gonzalez, Tiphanie; Hayes, B. Grant

    2009-01-01

    In 2000, Don Elligan introduced Rap Therapy as a psychotherapeutic intervention for working with at-risk youths, primarily African American males whose identities were highly influenced by rap music. Rap music can engage a population of youth who often enter counseling apprehensively (Elligan 2000, 2004; Tillie-Allen, 2005). This article reviews…

  18. "They Don't Know Anything!": Latinx Immigrant Students Appropriating the Oppressor's Voice

    Science.gov (United States)

    Monzó, Lilia D.

    2016-01-01

    This article discusses internalized oppression among Latinx communities through a revolutionary critical pedagogy. Data from a two-year ethnography of Latinx immigrant families show that students were developing deficit perspectives toward their parents, claiming that "they don't know anything," based on their positioning as powerless…

  19. 77 FR 21556 - Don Pedro Hydroelectric Project: Turlock Irrigation District; Modesto Irrigation District...

    Science.gov (United States)

    2012-04-10

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2299-075] Don Pedro Hydroelectric Project: Turlock Irrigation District; Modesto Irrigation District; Supplement to Notice of Study... Pedro Hydroelectric Project, Dispute Resolution Panel Chair, (202) 505-6861, [email protected] . d...

  20. The E-learning Cabaret: do's and don'ts in E-Learning Design

    NARCIS (Netherlands)

    Westera, Wim

    2009-01-01

    Westera, W. (2006). The E-Learning Cabaret: do's and don'ts in E-Learning Design. Book of Abstracts, 12th International Conference on Technology Supported Learning & Teaching, Online Educa Berlin (pp. 169-171). November, 29-December, 1, 2006, Berlin, Germany: ICWE-GmbH.

  1. 33 CFR 208.82 - Hetch Hetchy, Cherry Valley, and Don Pedro Dams and Reservoirs.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Hetch Hetchy, Cherry Valley, and..., Cherry Valley, and Don Pedro Dams and Reservoirs. The Turlock Irrigation District and Modesto Irrigation..., shall operate Hetch Hetchy Dam and Reservoir and Cherry Valley Dam and Reservoir in the interest of...

  2. "Don't Know" Responding to Answerable and Unanswerable Questions during Misleading and Hypnotic Interviews

    Science.gov (United States)

    Scoboria, Alan; Mazzoni, Giuliana; Kirsch, Irving

    2008-01-01

    "Don't know" (DK) responses to interview questions are conceptually heterogeneous, and may represent uncertainty or clear statements about the contents of memory. A study examined the subjective intent of DK responses in relation to the objective status of information queried, in the context of memory distorting procedures. Participants…

  3. DON JUAN: THE DISCOURSE OF SEDUCTION AS AN EXERCISE OF POWER

    Directory of Open Access Journals (Sweden)

    Kristina Stankevičiūtė

    2016-10-01

    Full Text Available The figure of Don Juan that emerged in Spanish baroque synthesised several important cultural issues related to the phenomenon of seduction, a subject of great social controversy since the very beginning of the Christian era. The present article analyses one of the fundamental parts of the universal appeal of the Don Juan figure – the discourse of seduction, considering it from the social and cultural point of view. The traditional discussion of the subject focuses on the contents of the discourse whereas the present article emphasises the implications rather than the contents, grounding its arguments on Jean Baudrillard’s theory of seduction, which claims that it is the signs and the play of signs that are important in seduction, not their meanings. The seduction discourse is seen as a means to exercise power on the women that Don Juan deals with as well as on the audience who gets involved into the discourse creation process. The article concludes with a claim that Don Juan is a figure of social domination, and his discourse is a means to achieve it.

  4. MEMS startups: disruptive technology and business do's and don'ts

    Science.gov (United States)

    Bryzek, Janusz

    2005-02-01

    This paper characterizes factors that affect the probability of success for new startups. These guidelines are derived primarily from Venture Capital industry experience in funding disruptive technology companies. It follows with an overview of Silicon Valley MEMS and MOEMS startups and provides with a summary of Do"s and Don"ts for entrepreneurs.

  5. Spendere meno, spendere meglio: una proposta panottica di J.-C. Guédon

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2013-06-01

    Full Text Available J.-C. Guédon ha commentato la nostra campagna di crowdsourcing in merito alle spese delle biblioteche sulla mailing list Nexa. Offriamo, qui di seguito, la versione italiana delle sue osservazioni – che presuppongono un mondo accademico molto diverso da quello impostoci...

  6. Teaching "Don Quixote" in the Digital Age: Page and Screen, Visual and Tactile

    Science.gov (United States)

    Boyle, Margaret; Hall, Crystal

    2016-01-01

    This current study describes an object-based learning approach to teaching "Don Quixote" as part of the curriculum for Spanish majors at a small liberal arts college. In order to maximize students' engagement with the narrative and the material culture of the novel, students worked with rare books, collaborative translation using Google…

  7. Where on Earth am I? Don't Worry,. GPS Satellites will Guide you

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 3; Issue 9. Where on Earth am I? Don't Worry, GPS Satellites will Guide you - Mechanisms and Uses of GPS. Makarand ... Author Affiliations. Makarand Phatak1. Aerospace Systems Private Ltd., Pragathi, 70/1, Miller Road Bangalore 560 052, India.

  8. Where on Earth am I? Don't Worry, GPS Satellites will Guide you ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 3; Issue 8. Where on Earth am I? Don't Worry, GPS Satellites will Guide you - Introduction and Principle of GPS. Makarand ... Author Affiliations. Makarand Phatak1. Aerospace Systems Private Ltd. Pragathi, 70/1, Miller Road, Bangalore 560 052, India.

  9. Imitate Me; Don't Imitate Me: Mimeticism in David Bartholomae's "Inventing the University."

    Science.gov (United States)

    Boyd, Richard

    1991-01-01

    Discusses the issue of the instructor's role in the classroom with respect to David Bartholomae's "Inventing the University." Suggests an approach informed by the literary and anthropological theories of Rene Girard. Deals with Girard's views on mimetic desire. Asserts the double-bind of this view--"imitate me; don't imitate…

  10. Il don giovanni tenorio di carlo goldoni. Alle origini di un mito moderno

    African Journals Online (AJOL)

    By transforming the protagonist's religious impiety into sexual incontinence, Goldoni draws a link between Molière's drama (1665) and the version set to music by Mozart in 1787. An analysis of the text with a focus on the reception and adaptation by Goldoni of the early plays reveals the centrality of his Don Giovanni in the ...

  11. Bentonite diminishes DON-induced changes in bone development in mink dams

    Directory of Open Access Journals (Sweden)

    Tomaszewska Ewa

    2016-09-01

    Full Text Available Introduction: The aim of this study was to determine the effect of deoxynivalenol (DON, given alone or with bentonite (which eliminates mycotoxicity in the diet of mink dams throughout mating, pregnancy, and lactation period to pelt harvesting, on the mechanical properties and geometry of their long bones.

  12. Don Diego Luis Moctezuma, nieto de Hueytlatoani, padre de conde: un noble indígena entre dos mundos

    Directory of Open Access Journals (Sweden)

    Francisco L. Jiménez Abollado

    2008-06-01

    Full Text Available The present work tries to explain the proceeding and discharge of don Diego Luis Moctezuma Ilhuitltemoctzin, grandson of the hueytlatoani Moctezuma Xocoyotzin, son of don Pedro Moctezuma Tlacahuepantzin and father of don Pedro Tesifón Moctezuma, the first Count of Moctezuma and Vizconde de Ilucan. Don Diego Luis Moctezuma played an important role during the second half of the 16th century and the first years of the XVIIth, first as son of don Pedro Moctezuma, who sends it to the Court and Kingdom of Castile to defending before the King of Spain and the Council of The Indies his interests as legitimate inheritor of Moctezuma Xocoyotzin. Later, when don Diego Luis converted into successor of his brother don Martin Cortés Moctezuma, one sees affected by the politics of the Crown and the Council of The Indies of systematic weakening of the indigenous nobility. His departure of the New Spain and the promises broken by part of the Crown determine the politics of Philip II and Philip III with the inheritors of Moctezuma Xocoyotzin.

  13. A Narrative Recreation of Don Quixote at Mid-Twentieth Century: Don Quijote en las Améscoas, by Martín Larráyoz Zarranz

    Directory of Open Access Journals (Sweden)

    Carlos Mata Induráin

    2011-12-01

    Full Text Available This article examines a narrative recreation of Don Quixote at mid-twentieth century, Don Quijote en las Améscoas, by Martín Larráyoz Zarranz, who takes Don Quixote and Sancho Panza to Navarre. The novel, published in 1954 at a diocesan magazine of Pamplona and then in book form in 1993, is another link in the long and fruitful chain of recreations of Cervantes’ immortal character and his adventures, a proof of its validity as an universal myth.

  14. Transient identification system with noising data and 'don't know' response

    International Nuclear Information System (INIS)

    Mol, Antonio C. de A.; Martinez, Aquilino S.; Schirru, Roberto

    2002-01-01

    In the last years, many different approaches based on neural network (NN) has been proposed for transient identification in nuclear power plants (NPP). Some of them focus the dynamic identification using recurrent neural networks however, they are not able to deal with unrecognized transients. Other kind of solution uses competitive learning in order to allow the 'don't know' response. In this case dynamic, dynamic features are not well represented. This work presents a new approach for neural network based transient identification which allows either dynamic identification and 'don't know'response. Such approach uses two multilayer neural networks trained with backpropagation algorithm. The first one is responsible for the dynamic identification. This NN uses, a short set (in a movable time window) of recent measurements of each variable avoiding the necessity of using starting events. The other one is used to validate the instantaneous identification (from the first net) through the validation of each variable. This net is responsible for allowing the system to provide 'don't know' response. In order to validate the method a NPP transient identification problem comprising 15 postulated accidents, simulated for a pressurized water reactor, was proposed in the validation process it has been considered noising data in other to evaluate the method robustness. Obtained results reveal the ability of the method in dealing with both dynamic identification of transients and correct 'don't know' response. In order to validate the method, a NPP transient identification problem comprising 15 postulated accidents simulated for a pressurized water reactor, was proposed in the validation process it has been considered noising data in order to evaluate the method robustness. Obtained results reveal the ability of the method in dealing with both dynamic identification of transients and correct 'don't know' response. (author)

  15. Individual and combined effects of deoxynivalenol and α-zearalenol on cell proliferation and steroidogenesis of granulosa cells in cattle.

    Science.gov (United States)

    Pizzo, Fabiola; Caloni, Francesca; Schutz, Luis F; Totty, Morgan L; Spicer, Leon J

    2015-11-01

    This study was conducted to evaluate the impact of deoxynivalenol (DON) and zearalenone (ZEA) metabolite, α-zearalenol (α-Zol), on cell proliferation and steroidogenesis of bovine large (LG) follicle granulosa cells (GC). LGGC were obtained from bovine ovarian follicles (8-22 mm) and were cultured for 2 days in medium containing 10% fetal bovine serum followed by 1 or 2 days in serum-free medium without (control) or with treatments. Three different experiments were performed using different dosages of DON and α-Zol and in different combinations and a fourth experiment evaluated estradiol effects on granulosa cell proliferation. DON inhibited progesterone (P4) and estradiol (E2) production at high dose. α-Zol alone and in combination with DON increased cell growth. Estradiol inhibited cell growth indicating α-Zol is not acting as an estrogen agonist. This study demonstrates that α-Zol and DON can impact in vitro GC function, however further studies will be required to better understand the mechanism of action and reproductive effects of Fusarium mycotoxins. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Do cells care about physics?

    Science.gov (United States)

    Guck, Jochen

    2009-07-01

    Ever since James Watson and Francis Crick cracked the code of life and laid the foundations for molecular biology, biologists have almost exclusively focused on the molecular aspects of biological systems. This cumulated in the mapping of the entire human genome a few years ago-the entire blueprint of every cell. So, does that mean we can stop? Is everything known that we can possibly know about cells? Far from it.

  17. Don't Let Gun Sports Backfire on You: Use Ear Protection and Hang onto Your Hearing

    Science.gov (United States)

    ... NIDCD Newsletter » Spring 2006 Don't Let Gun Sports Backfire on You: Use Ear Protection and Hang ... them. Likewise, Dave Henderson, a nationally recognized outdoor sports writer and hunting expert, wouldn't dream of ...

  18. “I don't use a condom (with my regular partner) because I know that I ...

    African Journals Online (AJOL)

    I don't use a condom (with my regular partner) because I know that I'm faithful, but with everyone else I do”: The cultural and socioeconomic determinants of sexual partner concurrency in young South Africans.

  19. The first theatrical adaptations of the Don Quixote and the beginning of Cervantes

    OpenAIRE

    Carmen Rivero Iglesias

    2012-01-01

    The present study analyzes the first appearances of Don Quixote on German stages. The goal is to illustrate how these theatrical performances determine the reception of Cervantes’ work in 17th century Germany. The first performances in Heidelberg (1613) and Dessau (1614) display an interpretation of Don Quixote, which intensifies the grotesque dimension of Cervantes’ original. Its satire is transformed into a satire of Spain in a context determined by political and religious animosity between...

  20. Deoxynivalenol (DON Contamination of Feed and Grinding Fineness: Are There Interactive Implications on Stomach Integrity and Health of Piglets?

    Directory of Open Access Journals (Sweden)

    Sven Dänicke

    2017-01-01

    Full Text Available The common feed contaminant deoxynivalenol (DON was reported to influence the morphology of the pars nonglandularis (PN of porcine stomach. Moreover, finely ground feed is known to trigger the development of ulcers and other pathologies of PN while coarsely ground feed protects from such lesions. The interactions between grinding fineness and DON contamination of feed were not examined so far. Therefore, both finely and coarsely ground feeds were tested either in the absence or presence of a DON contaminated wheat on growth performance and health of rearing piglets, including stomach integrity. DON contamination significantly reduced feed intake and serum albumin concentration with this effect being more pronounced after feeding the coarsely ground feed. Albeit at a higher level, albumin concentration was also reduced after feeding the finely ground and uncontaminated feed. Finely ground and DON-contaminated feed caused a significantly more pronounced lymphoplasmacytic infiltration both of PN and pars glandularis, partly paralleled by lymph follicle formation and detritus filled foveolae and tubes suggesting a local immune response probably triggered by epithelial lesions. It is concluded that DON contamination of feed exacerbates the adverse effects of finely ground feed on stomach mucosal integrity.

  1. The hallmarks of cell-cell fusion.

    Science.gov (United States)

    Hernández, Javier M; Podbilewicz, Benjamin

    2017-12-15

    Cell-cell fusion is essential for fertilization and organ development. Dedicated proteins known as fusogens are responsible for mediating membrane fusion. However, until recently, these proteins either remained unidentified or were poorly understood at the mechanistic level. Here, we review how fusogens surmount multiple energy barriers to mediate cell-cell fusion. We describe how early preparatory steps bring membranes to a distance of ∼10 nm, while fusogens act in the final approach between membranes. The mechanical force exerted by cell fusogens and the accompanying lipidic rearrangements constitute the hallmarks of cell-cell fusion. Finally, we discuss the relationship between viral and eukaryotic fusogens, highlight a classification scheme regrouping a superfamily of fusogens called Fusexins, and propose new questions and avenues of enquiry. © 2017. Published by The Company of Biologists Ltd.

  2. Tras las huellas de Don Pedro Fermín de Vargas

    Directory of Open Access Journals (Sweden)

    Sergio Elías Ortíz

    1964-08-01

    Full Text Available Recibida en Madrid, a fines de 1790, una información sobre la virtud curativa de ciertas plantas del Virreynato de la Nueva Granada, cuestión que preocupó a los botánicos de la corte llamados a conjeturar sobre ellas, el Ministro de Estado, Marqués de Bajamar, se dirigió al Virrey Ezpeleta, en abril del año siguiente, en solicitud de una porción de la yerba Guaco, con la descripción hecha por don Pedro Fermín de Vargas, "y de la del Jaguo, u otro Obo de flor moradita, con expresión facultativa de la especie y virtud medicinal de otras plantas", cuyo envío debía confiarse al Director Botánico don Josef Celestino Mutis".

  3. Don Quijote, doña Rodríguez y los duques

    Directory of Open Access Journals (Sweden)

    Stanislav Zimic

    1997-12-01

    Full Text Available Al llegar Don Quijote al palacio de los duques y "viéndose tratar del mesmo modo que él había leído se trataban Ios tales caballeros en Ios pasados siglos ... , aquél fue el primer día que de todo en todo conoció y creyó ser caballero andante verdadero y no fantastíco" (1378. Comprensiblemente, esta afirmacion ha causado gran perplejidad entre los lectores de todas las épocas: "Luego, antes ¿no lo había creído?" . La cuestión se complica mucho más, poco después de estos eufóricos momentos, al confesar Don Quijote a la duquesa: "Dios sabe si hay Dulcinea o no en el mundo, o si es fantástica ono es fantástica ...

  4. The first theatrical adaptations of the Don Quixote and the beginning of Cervantes

    Directory of Open Access Journals (Sweden)

    Carmen Rivero Iglesias

    2012-12-01

    Full Text Available The present study analyzes the first appearances of Don Quixote on German stages. The goal is to illustrate how these theatrical performances determine the reception of Cervantes’ work in 17th century Germany. The first performances in Heidelberg (1613 and Dessau (1614 display an interpretation of Don Quixote, which intensifies the grotesque dimension of Cervantes’ original. Its satire is transformed into a satire of Spain in a context determined by political and religious animosity between Catholics and Protestants. The first German translation inherited this conception of Cervantes’ work. This conception would acquire new shades until middle of the 18th century, when the alteration of historical coordinates and the rise of individuality and genius thoroughly transformed its interpretation.

  5. Five things they don't teach you in medical school.

    Science.gov (United States)

    Ball, Chad G; Grondin, Sean C; Dixon, Elijah; Lillemoe, Keith D; Bhandari, Mohit; Parry, Neil

    2016-09-01

    You graduate from medical school with dreams of beginning your residency, during which you will study and train within the specialty you love more than any other. While you may be book-smart at this point in your career, medical school does not teach you everything you need to know. During residency you will learn the didactic and technical requirements for your future staff job, but medical school won't explicitly address many of the crucial "dos and don'ts" of a successful 2- to 5-year postgraduate training voyage. Here we discuss a few of the important things about residency that you'll need to know that they don't teach you in medical school.

  6. ["Is it an animal inside? "Melanie Klein's unpublished Don Juan Paper (1939)].

    Science.gov (United States)

    Frank, Claudia

    2008-01-01

    Klein had been asked to contribute an article to the birthday number of the International Journal for Jones. The author outlines how she hurriedly wrote a text about Don Juan which, however, was rejected by the editor. Essential parts of it are presented in German translation. The manuscript is discussed in the context of Klein's published work as well as of the relevant contemporary literature. In Klein's view, Don Juan's genitality is determined by oral impulses and fears. By his manic acting out he attempts to ward off a depressive break-down. The paper ends with some reflections about why Klein--ontrary to her intention--failed to revise her manuscript for later publication.

  7. Operatic films: a comparative study of Don Giovanni by Joseph Losey and Juan by Kasper Holten

    Directory of Open Access Journals (Sweden)

    Isabel VILLANUEVA BENITO

    2017-12-01

    Full Text Available From an artistic point of view, the adaptation of an opera to the cinema, traditionally has been considered a complex and controversial process. Don Giovanni, of W.A. Mozart is one of the operas that more audiovisual versions has generated during the centuries XX and XXI, although very few films have finally been taken to the screen. This paper is focused on comparing the audiovisual versions Don Giovanni, by Joseph Losey (1979, and Juan by Kasper Holten (2010. Through a quantitative and qualitative methodology based on content analysis, this research reflects on the degree of intervention exercised by the language and audiovisual format used in the process of reinterpretation of the pre-existing operatic text.

  8. Influence of the mycotoxins alpha- and beta-zearalenol and deoxynivalenol on the cell cycle of cultured porcine endometrial cells.

    Science.gov (United States)

    Tiemann, U; Viergutz, T; Jonas, L; Schneider, F

    2003-01-01

    The present study investigated the effects of the mycotoxins alpha-zearalenol (alpha-ZOL) and beta-zearalenol (beta-ZOL) at concentrations of 7.5, 15, and 30 microM, and deoxynivalenol (DON) at concentrations of 0.94, 1.88, and 3.76 microM on cell cycle distribution (propidium iodide, PI staining) in combination with the proliferating cell nuclear antigen (PCNA) by flow cytometry. The viability of porcine uterine cells was not impaired at 30 microM alpha-ZOL, whereas beta-ZOL at this concentration and 3.76 microM DON significantly decreased cell number. Some cells showed ultrastructural features of cell death indicated by swollen mitochondria, disrupted cell membranes, and many vacuoles. After 24 and 48h of exposure to alpha-ZOL (7.5, 15, or 30 microM), the cell cycle distribution was still comparable to the control groups. An anti-proliferative effect of beta-ZOL and DON was detected by a significant reduction in the S-phase together with arrest of cells in the G(0)/G(1)-phase. The results show that beta-ZOL (7.5, 15, or 30 microM) and DON (0.94, 1.88, or 3.76 microM) control the progression of cells through the cycle by decreasing S-phase and arresting cells in the G(0)/G(1)-phase of the cell cycle. A significant decrease in the expression of the proliferation marker PCNA amounts indicates that beta-ZOL and DON disengaged cells from active cycling. We confirm that alpha-ZOL possesses a relative binding affinity to porcine uterine cytoplasmic estrogen receptor.

  9. From stem cells to human development: a distinctly human perspective on early embryology, cellular differentiation and translational research.

    Science.gov (United States)

    Craft, April M; Johnson, Matthew

    2017-01-01

    Over 100 scientists with common interests in human development, disease and regeneration gathered in late September 2016 for The Company of Biologists' second 'From Stem Cells to Human Development' meeting held in historic Southbridge. In this Meeting Review, we highlight some of the exciting new findings that were presented, and discuss emerging themes and convergences in human development and disease that arose during these discussions. © 2017. Published by The Company of Biologists Ltd.

  10. Study on the structures and anti-hepatic fibrosis activity of stilbenoids from Arundina graminifolia (D. Don) Hochr.

    Science.gov (United States)

    Liu, Qingqing; Wang, Huiting; Lin, Fankai; Dai, Rongji; Yu, Deng lin; Lv, Fang

    2017-12-01

    A phytochemical study was performed on Arundina graminifolia (D.Don) Hochr. by silica gel column and semi-preparative HPLC, and ten stilbenoids were obtained. Their structures were elucidated by NMR and MS spectra and identified as 7-hydroxy-2,4-dimethoxy-9,10-dihydrophenanthrene (1), 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (2), 2,7-dihydroxy-4-methoxy-9,10-dihydrophenanthrene (3), 3,3’-dihydroxy-5-methoxy-bibenzyl (4), 7-hydroxy-2,8-dimethoxy-phenanthrene-1,4-dione (5), 7-hydroxy-2,10-dimethoxy-phenanthre-ne-1,4-dione (6), 7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene-1,4-dione (7), 7-hydroxy-2-methoxy-phenanthrene-1,4-dione (8), 7-hydroxy-1-(p-hydroxybenzyl)-2,4-dimethoxy-9,10-dihydroxy-phenanthrene (9), 2,7-dihydroxy-1-(p-hydroxybenzyl)-4-methoxy-9,10-dihydroxy-phenanthrene (10). Compounds 5 and 6 were isolated from this plant for the first time. The isolated compounds were examined for their anti-hepatic fibrosis activity against HSC-T6 cells in vitro. The results showed that compounds 4 and 5 exhibited moderate growth inhibitory effects with IC50 61.9 μg/mL and 52.7 μg/mL, respectively.

  11. Now You See Me, Now You Don't

    NARCIS (Netherlands)

    Jainandunsing, Jayant S.; Jeganathan, Jelliffe; Scheeren, Thomas W. L.; Natour, Ehsan

    A 60-YEAR-OLD MALE was undergoing radical nephrectomy under transesophageal echocardiographic (TEE) guidance for renal cell carcinoma. The tumor was known to extend to the lumen of the inferior vena cava through the renal vein (Fig 1). During extraction, a large portion of the tumor was dislodged

  12. Real men don't beat their wives!

    OpenAIRE

    Kaur, Dr Gurmeen

    2010-01-01

    Despite the numerous Domestic violence laws, women protection acts and women cells in India at present; physical abuse and domestic violence is still rampant and grossly underreported. This article describes my experience in dealing with victims of domestic abuse as a medical student.

  13. The fusarium mycotoxin deoxynivalenol can inhibit plant apoptosis-like programmed cell death.

    Directory of Open Access Journals (Sweden)

    Mark Diamond

    Full Text Available The Fusarium genus of fungi is responsible for commercially devastating crop diseases and the contamination of cereals with harmful mycotoxins. Fusarium mycotoxins aid infection, establishment, and spread of the fungus within the host plant. We investigated the effects of the Fusarium mycotoxin deoxynivalenol (DON on the viability of Arabidopsis cells. Although it is known to trigger apoptosis in animal cells, DON treatment at low concentrations surprisingly did not kill these cells. On the contrary, we found that DON inhibited apoptosis-like programmed cell death (PCD in Arabidopsis cells subjected to abiotic stress treatment in a manner independent of mitochondrial cytochrome c release. This suggested that Fusarium may utilise mycotoxins to suppress plant apoptosis-like PCD. To test this, we infected Arabidopsis cells with a wild type and a DON-minus mutant strain of F. graminearum and found that only the DON producing strain could inhibit death induced by heat treatment. These results indicate that mycotoxins may be capable of disarming plant apoptosis-like PCD and thereby suggest a novel way that some fungi can influence plant cell fate.

  14. Zur Entstehung, Konzeption und Wirkung des "Don Quijote" in der europäischen Literatur

    OpenAIRE

    Meyer-Minnemann, Klaus

    2007-01-01

    Wie kein zweiter Roman zieht der "Don Quijote" von Miguel de Cervantes seit nunmehr vier Jahrhunderten Generationen von Lesern immer wieder neu in seinen Bann. Abgefasst im Spanien des frühen 17. Jahrhunderts, das zu jener Zeit die Geschicke Europas wesentlich mitbestimmte, wurde der Roman bald zum Inbegriff der spanischen Literatur und Kultur. Von Madrid aus hat er auf den Rest Europas ausgestrahlt und Denker, Dichter, Künstler, Komponisten und später auch Filmemacher zur Auseinandersetzung ...

  15. Mujeres españolas de la conquista en don Joan de Castellanos (I

    Directory of Open Access Journals (Sweden)

    Mario Germán Romero

    1962-10-01

    Full Text Available La participación de la mujer española en la conquista de América es un tema que apenas comienza a ser tratado con la profundidad que merece. A principios del siglo don Cesáreo Fernández Duro publicó una breve disertación sobre ' 'La mujer española en Indias".

  16. Reproduction et Diversité Génétique chez Parkia biglobosa (Jacq.) G. Don

    NARCIS (Netherlands)

    Sina, S.

    2006-01-01

    Parkiabiglobosa(Jacq.)G.Don, African

  17. Punctuation in the text of the Golden Age and in Don Quijote

    Directory of Open Access Journals (Sweden)

    Ignacio Arellano

    2010-12-01

    Full Text Available This article examines the punctuation in Golden Age texts, in particular in Don Quixote. The author analyzes the discrepancies between theory and practice of the printers, the features of the punctuation in manuscripts, and the absence of a general system, due in part to the absence of a unique and precise system in Spanish. The article provides numerous examples of Golden Age text and of the Quixote.

  18. Ecological aspects in assessment of acoustic pollution at the territory of Rostov-on-Don

    Directory of Open Access Journals (Sweden)

    Sheina Svetlana

    2017-01-01

    Full Text Available Dynamic changes of urban environment determined by fulfillment of multiple residential and public edifices, reclamation of vast spaces, massive reformation of former industrial, warehouse and port edifices, carry considerable possibilities for current formation of architecture and urbanization of spaces of increased comfort with optimal functional organization. Article is devoted to environmental aspects of territory acoustic pollution assessment in Rostov-on-Don.

  19. Don E. Detmer and the American Medical Informatics Association: An Appreciation

    Science.gov (United States)

    Shortliffe, Edward H.; Bates, David W.; Bloomrosen, Meryl; Greenwood, Karen; Safran, Charles; Steen, Elaine B.; Tang, Paul C.; Williamson, Jeffrey J.

    2009-01-01

    Don E. Detmer has served as President and Chief Executive Officer of the American Medical Informatics Association (AMIA) for the past five years, helping to set a course for the organization and demonstrating remarkable leadership as AMIA has evolved into a vibrant and influential professional association. On the occasion of Dr. Detmer's retirement, we fondly reflect on his professional life and his many contributions to biomedical informatics and, more generally, to health care in the U.S. and globally. PMID:19574463

  20. Detsibill : Meie Mees kui ANTI. White Label : Don Erikson. Kuula / DJ Pickney Tiger

    Index Scriptorium Estoniae

    DJ Pickney Tiger, pseud., 1970-

    2006-01-01

    Heliplaatidest: Don Erikson "Israel Mix", Congotronics 2 "Buzz'n'rumble from the urb'n'jungle", Critikal "Chapter One ehk Teine maitse", Nirvana "Silver, The best of the Box", Singer Vinger "Eesti Kullafond", Bullet Train To Vegas "We Put Scissors Where Our Mouths Are", Ludachris "Disturbing tha peace", "Soul Satisfaction 5", The Kurt Webber's Pink Band "Café Regatt", Patrizio Buanne "The Italian", Eminem "Curtain Call"

  1. STS-70 Pilot Kevin Kregel donning his launch/entry suit

    Science.gov (United States)

    1995-01-01

    STS-70 Pilot Kevin Kregel is donning his launch/entry suit in the Operations and Checkout Building with help from a suit technician. Kregel, who is about to make his first trip into space, and four crew members will shortly depart for Launch Pad 39B, where the Space Shuttle Discovery is undergoing final preparations for a liftoff scheduled during a two and a half hour launch window opening at 9:41 a.m. EDT.

  2. STS-38 Mission Specialist (MS) Robert C. Springer dons EMU in JSC's WETF

    Science.gov (United States)

    1990-01-01

    STS-38 Mission Specialist (MS) Robert C. Springer, wearing extravehicular mobility unit (EMU), fastens the strap on his communications carrier assembly (CCA) cap during suit donning in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Positioned on the WETF platform at pool side, Springer is preparing for an underwater extravehicular activity (EVA) simulation. During the training exercise, Springer will rehearse contingency EVA procedures for the STS-38 mission aboard Atlantis, Orbiter Vehicle (OV) 104.

  3. Application of gamma radiation to the nodes detection in Pinus Radiata (D.Don) wood pieces

    International Nuclear Information System (INIS)

    Morales, J.R.; Dinator, Maria I; Karsulovic C, Jose T.; Leon G, Adolfo

    1996-01-01

    Attenuation of 59.5 KeV photons provided by an Am-241 source, has been used to detect knots in lumber pieces from Pinus Radiata (D.Don). It is shown that the linear attenuation coefficient is a sensitive parameter to detect singularities in the structure of this material. The scanning of the piece provides profiles which define the position and extension of the singularity. (author)

  4. De meilleures données probantes sur les dons privés dans les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Malgré la croissance de la philanthropie dans les économies émergentes, on relève d'importantes lacunes dans les données relatives aux montants et à la provenance des fonds. Il existe aussi une pénurie de recherches sur les règlements et les politiques qui appuient ou découragent les dons privés. Ce projet de ...

  5. Don Quixote Intends to give us Music; and Being his it will not be Bad

    Directory of Open Access Journals (Sweden)

    Leonardo Sancho

    2015-11-01

    Full Text Available The Ingenious Gentleman Don Quixote of La Mancha is crossed with a quantity and variety of poems that result being eco of the events that happen in the narration. In this opportunity the romance is analyzed and commented. «Mighty Love the hearts of maidens», of chapter XLVI of the Second Part, is an example of the Cervantes poetics of love and cavalry that weaves relationships with other events, themes and poems, inserted in the Cervantes novel.

  6. Improving eyewitness identification accuracy by screening out those who say they don't know.

    Science.gov (United States)

    Weber, Nathan; Perfect, Timothy J

    2012-02-01

    Improving eyewitness identification evidence remains a key priority for research. Basic laboratory research has consistently demonstrated that allowing participants to withhold answers about which they are unsure leads to improved accuracy. Surprisingly, this approach has not been the subject of comprehensive investigation in the eyewitness identification literature. In this article, we explored the utility of allowing uncertain witnesses to opt out of an identification decision, by providing an explicit don't know option. Further, we contrasted the rate of use of this explicit option with the frequency that participants spontaneously withheld a decision when asked to respond in their own words. Four hundred and twenty participants witnessed a mock crime video before being presented with a showup of the perpetrator or an innocent suspect. Participants were tested either immediately or after a 3-week delay, with one of the three report options: Participants either made their choice in their own words (spontaneous report), chose between identifying and rejecting the showup (forced-report), or chose between identification, rejection and don't know (free-report). Only 2.2% of witnesses spontaneously used a don't know response, compared to 19.3% who used it when the option was explicit. Compared with the forced-report decisions, free-report decisions were more accurate, more diagnostic of the suspect's guilt or innocence, and came at no cost to the number of correct decisions rendered. These data suggest that utilisation of an explicit don't know option may be of practical value. (c) 2012 APA, all rights reserved.

  7. La parodia como marco estructural en Don Quijote y Los viajes de Gulliver

    Directory of Open Access Journals (Sweden)

    Alfonso Muñoz Corcuera

    2016-07-01

    Full Text Available Los viajes de Gulliver, de Jonathan Swift, es una de las obras más conocidas de la literatura universal. Sin embargo, su recepción actual, al menos en España, se produce sobre todo por medio de adaptaciones en las que no se puede apreciar el calado de la obra literaria original. En este estudio se pretende profundizar en el análisis de Los viajes de Gulliver a través de una comparación con Don Quijote, enfocándose en los recursos paródicos: mientras Don Quijote parodia los libros de caballerías, Los viajes de Gulliver parodia los libros de viajes. El principal objetivo de esta comparación no será tanto demostrar una influencia de la obra de Cervantes sobre la de Swift, sino, más bien, iluminar algunos aspectos de Los viajes de Gulliver. Gulliver´s Travels, of Jonathan Swift, is one of the most well-known works in world literature. However, its actual reception, at least in Spain, it´s produced mostly through adaptations in which it´s impossible to appreciate the profundity of the original literary work. In this article, I intend to dig deeply into the analysis of Gulliver´s Travels through a comparison with Don Quixote, focusing on the parodic resources: while Don Quixote parodies the books of chivalry, Gulliver´s Travels parodies travel books. The main goal of this comparison will not be to prove some influence of Cervantes´ work in Swift´s work, but to illuminate some aspects of Gulliver´s Travels.

  8. Getting beyond "Don't ask; don't tell": an evaluation of US Veterans Administration postdeployment mental health screening of veterans returning from Iraq and Afghanistan.

    Science.gov (United States)

    Seal, Karen H; Bertenthal, Daniel; Maguen, Shira; Gima, Kristian; Chu, Ann; Marmar, Charles R

    2008-04-01

    We sought to evaluate outcomes of the Veterans Administration (VA) Afghan and Iraq Post-Deployment Screen for mental health symptoms. Veterans Administration clinicians were encouraged to refer Iraq or Afghanistan veterans who screened positive for posttraumatic stress disorder, depression, or high-risk alcohol use to a VA mental health clinic. Multivariate methods were used to determine predictors of screening, the proportions who screened positive for particular mental health problems, and predictors of VA mental health clinic attendance. Among 750 Iraq and Afghanistan veterans who were referred to a VA medical center and 5 associated community clinics, 338 underwent postdeployment screening; 233 (69%) screened positive for mental health problems. Having been seen in primary care (adjusted odd ratio [AOR]=13.3; 95% confidence interval [CI]=8.31, 21.3) and at a VA community clinic (AOR=3.28; 95% CI=2.03, 5.28) predicted screening. African American veterans were less likely to have been screened than were White veterans (AOR=0.45; 95% CI=0.22, 0.91). Of 233 veterans who screened positive, 170 (73%) completed a mental health follow-up visit. A substantial proportion of veterans met screening criteria for co-occurring mental health problems, suggesting that the VA screens may help overcome a "don't ask, don't tell" climate that surrounds stigmatized mental illness. Based on data from 1 VA facility, VA postdeployment screening increases mental health clinic attendance among Iraq and Afghanistan veterans.

  9. Bioethics of the refusal of blood by Jehovah's Witnesses: Part 3. A proposal for a don't-ask-don't-tell policy.

    Science.gov (United States)

    Muramoto, O

    1999-01-01

    Of growing concern over Jehovah's Witnesses' (JWs) refusal of blood is the intrusion of the religious organisation into its members' personal decision making about medical care. The organisation currently may apply severe religious sanctions to JWs who opt for certain forms of blood-based treatment. While the doctrine may be maintained as the unchangeable "law of God", the autonomy of individual JW patients could still be protected by the organisation modifying its current policy so that it strictly adheres to the right of privacy regarding personal medical information. The author proposes that the controlling religious organisation adopt a "don't-ask-don't-tell" policy, which assures JWs that they would neither be asked nor compelled to reveal personal medical information, either to one another or to the church organisation. This would relieve patients of the fear of breach of medical confidentiality and ensure a truly autonomous decision on blood-based treatments without fear of organisational control or sanction. PMID:10635499

  10. El don: entre las prácticas intersticiales y el solidarismo

    Directory of Open Access Journals (Sweden)

    ADRIÁN SCRIBANO

    2014-08-01

    Full Text Available El presente trabajo busca hacer evidente al solidarismo como la "pérdida del don", conforme expuesto por Mauss, en el contexto de la situación colonial, de los procesos de expansión capitalista en la actualidad. Como objeto de análisis y mediación hermenéutica, hemos seleccionado a la Responsabilidad Social Empresarial (RSE como una forma del solidarismo cuyas prácticas llevan a un conjunto de situaciones que pueden describirse como pornográficas. Para lograr el objetivo explicitado, hemos seguido la siguiente estrategia argumentativa: a se sintetizan algunas pocas coordenadas de carácter teóricos que permitan entender la centralidad del don y se explicita nuestra idea de solidarismo, b se realiza un triple análisis: de la conceptualización de la RSE y de las experiencias de RSE de algunas corporaciones internacionales en Argentina; y c se exponen nuestras ideas sobre prácticas intersticiales en tanto hiatos que quiebran a la economía política de la moral como una totalidad que demanda la "pérdida" de todo tipo de don.

  11. Change and persistence in land surface phenologies of the Don and Dnieper river basins

    International Nuclear Information System (INIS)

    Kovalskyy, V; Henebry, G M

    2009-01-01

    The formal collapse of the Soviet Union at the end of 1991 produced major socio-economic and institutional dislocations across the agricultural sector. The picture of broad scale patterns produced by these transformations continues to be discovered. We examine here the patterns of land surface phenology (LSP) within two key river basins-Don and Dnieper-using AVHRR (Advanced Very High Resolution Radiometer) data from 1982 to 2000 and MODIS (Moderate Resolution Imaging Spectroradiometer) data from 2001 to 2007. We report on the temporal persistence and change of LSPs as summarized by seasonal integration of NDVI (normalized difference vegetation index) time series using accumulated growing degree-days (GDDI NDVI). Three land cover super-classes-forest lands, agricultural lands, and shrub lands-constitute 96% of the land area within the basins. All three in both basins exhibit unidirectional increases in AVHRR GDDI NDVI between the Soviet and post-Soviet epochs. During the MODIS era (2001-2007), different socio-economic trajectories in Ukraine and Russia appear to have led to divergences in the LSPs of the agricultural lands in the two basins. Interannual variation in the shrub lands of the Don river basin has increased since 2000. This is due in part to the better signal-to-noise ratio of the MODIS sensor, but may also be due to a regional drought affecting the Don basin more than the Dnieper basin.

  12. Hubungan antara Aktivitas Fisik Terhadap Memori Kerja Murid SMA Don Bosco III Bekasi

    Directory of Open Access Journals (Sweden)

    Michelle Clarissa Junaidi

    2017-03-01

    Full Text Available Latar belakang. Memori kerja merupakan bagian dari memori jangka pendek yang berperan penting dalam membantu proses pembelajaran dan dipengaruhi oleh aktivitas fisik, memori kerja yang rendah akan menimbulkan kesulitan untuk menerima informasi baru serta penurunan prestasi belajar. Tujuan. Mengetahui pengaruh aktivitas fisik terhadap kapasitas memori kerja murid SMA Don Bosco III. Metode. Penelitian metode analitik dengan pendekatan potong lintang pada 113 murid SMA Don Bosco III, Bekasi, pada 18 – 20 Juli 2016. Penelitian dilakukan dengan menggunakan kuesioner demografi, kuesioner skrining gangguan mental dan penyakit kronis, Physical Acitivity Questionnaire of Adolescent (PAQ-A dan Operation Span (O-SPAN. Analisis data dengan univariat dan bivariat menggunakan uji korelasi Spearman. Hasil. Terdapat 113 murid SMA Don Bosco III dengan kisaran usia 14 – 17 tahun, usia terbanyak 15 tahun (47.8%, laki-laki 61,1%, murid kelas X 44.2%. Mayoritas responden memiliki aktivitas fisik “kurang baik” dan rerata memori kerja 6,16. Analisis Spearman menunjukkan terdapat hubungan bermakna (p<0,05 antara aktivitas fisik terhadap memori kerja dengan korelasi positif lemah (r=0,384. Kesimpulan. Terdapat korelasi positif antara aktivitas fisik dan memori kerja, aktivitas fisik yang semakin tinggi cenderung akan meningkatkan memori kerja.

  13. de "subirnos al tiempo". La economía del "don"

    Directory of Open Access Journals (Sweden)

    Raúl García Durán

    2007-01-01

    Full Text Available Este trabajo resume las ideas contenidas en el libro -aún inédito- De la miseria de la economía a la plenitud de la fraternidad; o la economía del "don" como alternativa al capitalismo y la economía de mercado. En él se plantean alternativas radicales al capitalismo; particularmente, se ubica al "don" como camino de pensamiento y acción. Se documentan las proposiciones teóricas y aportes de la economía política, la antropología, la historia, para construir la manera en que el don podría contribuir a una reorganización social basada en nuevos-viejos principios. Se interrogan diversas experiencias histórico-antropológicas y su prefiguración actual en un nuevo modelo ético-político-ecológico que abarca las dimensiones local y global.

  14. A neural model for transient identification in dynamic processes with 'don't know' response

    International Nuclear Information System (INIS)

    Mol, Antonio C. de A.; Martinez, Aquilino S.; Schirru, Roberto

    2003-01-01

    This work presents an approach for neural network based transient identification which allows either dynamic identification or a 'don't know' response. The approach uses two 'jump' multilayer neural networks (NN) trained with the backpropagation algorithm. The 'jump' network is used because it is useful to dealing with very complex patterns, which is the case of the space of the state variables during some abnormal events. The first one is responsible for the dynamic identification. This NN uses, as input, a short set (in a moving time window) of recent measurements of each variable avoiding the necessity of using starting events. The other one is used to validate the instantaneous identification (from the first net) through the validation of each variable. This net is responsible for allowing the system to provide a 'don't know' response. In order to validate the method, a Nuclear Power Plant (NPP) transient identification problem comprising 15 postulated accidents, simulated for a pressurized water reactor (PWR), was proposed in the validation process it has been considered noisy data in order to evaluate the method robustness. Obtained results reveal the ability of the method in dealing with both dynamic identification of transients and correct 'don't know' response. Another important point studied in this work is that the system has shown to be independent of a trigger signal which indicates the beginning of the transient, thus making it robust in relation to this limitation

  15. Effects of temperature and time on deoxynivalenol (DON and zearalenone (ZON content in corn

    Directory of Open Access Journals (Sweden)

    Jauković Marko

    2014-01-01

    Full Text Available Fumonisins are Fusarium mycotoxins that occur in corn and corn-based foods and they have been implicated in several animal and human diseases. Their effect on human health is unclear, however, fumonisins are considered to be risk factors for cancer. Baking, frying, and extrusion cooking of corn at high temperatures (190°C reduce fumonisin concentrations in foods, with the amount of reduction achieved depending on cooking time, temperature, recipe, and other factors. The aim of this work was to evaluate the effectiveness of temperature (200 and 220 °C and time (15 and 20 min on the detoxification of corn flour deliberately contaminated with DON and ZON. After processing at 200°C for 15 min, an average of 12% and after 20 min an average of 15% of DON was lost. At 200°C ZON content was reduced by 22% (after 15 min and by 27% (after 20 min. Higher temperature (220°C did not significantly affect further reduction of DON or ZON content. The process was only partially effective in both cases. [Projekat Ministarstva nauke Republike Srbije, br. TR-31023 i br. TR-31053

  16. "The herbs that have the property of healing...,": the phytotherapy in Don Quixote.

    Science.gov (United States)

    López-Muñoz, Francisco; Alamo, Cecilio; García-García, Pilar

    2006-07-19

    Don Quixote, the most outstanding novel of the Spanish literature, represents a documentary source widely used among those specialists who intend to deepen in the knowledge of the late Renaissance society. In this sense, Don Quixote has been also studied from a medical perspective, including a general therapeutical view (oils, ointments, balms, poultices, syrups and other pharmacy preparations). We have tackled Don Quixote from the phytotherapeutic and ethnopharmacological perspective, a barely explored field. In this work, we intend to study the medicinal plants used during the Cervantine time for the treatment de multiples diseases (sedatives like opium, laxatives and emetics like hellebore, tonics and irritants) and we analyze the specific herbal therapies (balms, purgatives and emetics, ointments and poultices), which Cervantes reveals to us in his novel. Among them, the rhubarb root (Rheum spp. or Rumex spp.) should be highlighted, as well as the seeds of gopher spurge (Euphorbia lathyris), chicory (Cichorium intybus) and rosemary (Rosmarinus officinalis), primary component of the famous Balsam of Fierabras. Also, we have examined the possible scientific influences, which might have inspired Cervantes in this field, mainly the work of Andrés Laguna (Dioscorides' Materia Medica).

  17. The Rhetoric of Madness in Kathy Acker’s Don Quixote

    Directory of Open Access Journals (Sweden)

    Claudia Cao

    2017-07-01

    Full Text Available This essay examines the rhetorical experimentation of Don Quixote by Kathy Acker, starting from a theoretical concept central in the author’s thought: her search for a “language of the body”. A brief introduction to Kathy Acker’s plagiaristic poetics frames her narrative strategies between postmodern rewriting and pastiche. It shows the way in which her Don Quixote transposes the representative scheme of the chivalric quest into the contemporary value system with the aim of questioning Cervantes’ text as one of the canonical works of the Western literary tradition. The following section deepens three focal concepts of Acker’s theoretical works – body, madness, and norm – illuminating the connections between her rhetorical experimentation and the works by Luce Irigaray and Judith Butler. Finally, the paper will demonstrate how these concepts in Acker's rewriting of Don Quixote are strictly related to paradox, which she uses in order to actualize a “language of the body”: in the passage from the former novel to the postmodern work, madness has become the device which, from the semantic level to the rhetorical one, expresses Acker’s idea of language of the body, as an alternative and in contrast to the canonical language of the logos.

  18. The voice of Cervantes «creator» in Don Quixote

    Directory of Open Access Journals (Sweden)

    Florencio Sevilla Arroyo

    2010-12-01

    Full Text Available The aim of this paper is identifying the genuine voice of the Cervantes creator in the multiple choir of fictitious intermediaries involved in the authorship and the story of Don Quijote (reporter, editor, translator, Cide Hamete, supernarrator, readers, etc. trying, at the same time, to gauging the sense and the scope of their interventions. It happens that Miguel de Cervantes keeps to himself a novelistic role radically different depending on whether it is about the «story of story» or the «story itself»: refering to the first one, the author is out of the cast, delegating the reconstruction of Don Quixote’s legend in multiple fictional masks always comically manipulated; on the other hand, when it is the turn to the novelistic design of the chivalrous adventures of Don Quixote and Sancho, the voice of Cervantes creator comes to the forefront in order to take on, —as the «final author»— all narrative responsibility with absolute omniscience and solemnity. The resulting Quijote can only be explained from the intersection of both attitudes: the risible story of the most solemn/serious and magnificent novelistic bet never tried out..

  19. Organ Damage and Hepatic Lipid Accumulation in Carp (Cyprinus carpio L.) after Feed-Borne Exposure to the Mycotoxin, Deoxynivalenol (DON)

    OpenAIRE

    Pietsch, Constanze; Schulz, Carsten; Rovira, Pere; Kloas, Werner; Burkhardt-Holm, Patricia

    2014-01-01

    Deoxynivalenol (DON) frequently contaminates animal feed, including fish feed used in aquaculture. This study intends to further investigate the effects of DON on carp (Cyprinus carpio L.) at concentrations representative for commercial fish feeds. Experimental feeding with 352, 619 or 953 μg DON kg−1 feed resulted in unaltered growth performance of fish during six weeks of experimentation, but increased lipid peroxidation was observed in liver, head kidney and spleen after feeding of fish wi...

  20. Information Technology Portfolio Management and the Real Options Method (ROM): Managing the Risks of IT Investments in the Department of the Navy (DON)

    National Research Council Canada - National Science Library

    Davis, Jeffery

    2003-01-01

    .... This research draws upon ITPM implementation strategies currently employed by the DON and provides recommendations for managing the inherent risk in IT investments, specifically the application...

  1. The illuminated plant cell.

    Science.gov (United States)

    Mathur, Jaideep

    2007-11-01

    The past decade has provided biologists with a palette of genetically encoded, multicolored fluorescent proteins. The living plant cell turned into a 'coloring book' and today, nearly every text-book organelle has been highlighted in scintillating fluorescent colors. This review provides a concise listing of the earliest representative fluorescent-protein probes used to highlight various targets within the plant cell, and introduces the idea of using the numerous multicolor, subcellular probes for the development of an early intracellular response profile of plants.

  2. Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth.

    Science.gov (United States)

    Grewal, Savraj S

    2015-07-01

    Transfer RNAs (tRNAs) are essential for mRNA translation. They are transcribed in the nucleus by RNA polymerase III and undergo many modifications before contributing to cytoplasmic protein synthesis. In this review I highlight our understanding of how tRNA biology may be linked to the regulation of mRNA translation, growth and tumorigenesis. First, I review how oncogenes and tumour suppressor signalling pathways, such as the PI3 kinase/TORC1, Ras/ERK, Myc, p53 and Rb pathways, regulate Pol III and tRNA synthesis. In several cases, this regulation contributes to cell, tissue and body growth, and has implications for our understanding of tumorigenesis. Second, I highlight some recent work, particularly in model organisms such as yeast and Drosophila, that shows how alterations in tRNA synthesis may be not only necessary, but also sufficient to drive changes in mRNA translation and growth. These effects may arise due to both absolute increases in total tRNA levels, but also changes in the relative levels of tRNAs in the overall pool. Finally, I review some recent studies that have revealed how tRNA modifications (amino acid acylation, base modifications, subcellular shuttling, and cleavage) can be regulated by growth and stress cues to selectively influence mRNA translation. Together these studies emphasize the importance of the regulation of tRNA synthesis and modification as critical control points in protein synthesis and growth. This article is part of a Special Issue entitled: Translation and Cancer. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. Mercedes y privilegios para consolidar un mayorazgo indiano: de don Pedro Moctezuma Tlacahuepantzin a don Pedro Tesifón Moctezuma, primer conde de Moctezuma (1569-1639

    Directory of Open Access Journals (Sweden)

    Francisco Luis Jiménez Abollado

    2015-06-01

    Full Text Available Las adjudicaciones de mercedes y privilegios se convirtieron para los descendientes de Moctezuma II en una forma de sobrevivir a lo largo del período virreinal. Para ello esgrimieron razonamientos fundamentados en su ascendencia, la transmisión pacífica a la Corona hispánica de su patrimonio territorial, así como una presumible pobreza o necesidad. Este análisis se centrará en los sucesores del único hijo varón de Moctezuma que sobrevivió a la conquista castellana: don Pedro Moctezuma Tlacahuepantzin. Las adjudicaciones de mercedes, ayudas de costas y encomiendas vacas fueron continuas entre el último tercio del siglo xvi hasta el fin del período virreinal.

  4. Cervantes, Lizardi, and the Literary Construction of The Mexican Rogue in Don Catrín de la fachenda

    Directory of Open Access Journals (Sweden)

    Vilches Patricia

    2017-12-01

    Full Text Available This study explores the socio-economic legacies and critique of nation-building found in the work of Jose Joaquin Fernandez de Lizardi (1776-1827. In the nineteenth century, the Latin American elite struggled to disassociate itself from a suffocating colonial machine; they sought their own identity, and writing became a way to express their frustration. As in other parts of Latin America, Mexican intellectuals protested fossilisation via Cervantes’s Don Quijote. Using the Spanish author’s text as a blueprint, Lizardi’s Don Catrín de la fachenda depicted a turbulent society that was in the process of abandoning a decaying colonial order. Don Quijote’s characters engaged in power struggles and were involved in a variety of forms of social antagonism. Lizardi juxtaposed and superimposed these on an American geographical and socio-economic space where there was much dissension around the nation’s direction. The social and economic rules of Mexico (and Latin America today can be said to be already present in the social exchanges in Don Catrín. It was in this context that Don Quijote was “Mexicanised” by Lizardi and thereby made to participate in local reflections on liberty, patriotism, capitalism, and citizenship. Cervantes’s text thus took on a socio-political meaning in the narrative of Latin America’s past and present.

  5. Don Quijote de la Mancha: Reflexiones en torno a las relaciones cine-literatura Don Quijote de la Mancha: Reflections about the relationships between cinematography-literature

    Directory of Open Access Journals (Sweden)

    Felipe Ardila Rojas

    2008-06-01

    Full Text Available Este artículo presenta un análisis de algunos aspectos de la relación cine-literatura, a partir del Don Quijote de La Mancha literario y de algunas versiones cinematográficas y televisivas realizadas en español y en inglés. Inicialmente se presentan problemas teóricos en torno a categorías que suelen serles afines: relato, autor, narración, historia, etc., para involucrar alternativamente fenómenos que, desde el punto de vista de los autores, generan ambigüedades textuales o múltiples interpretaciones en las versiones que se analizan. De este análisis comparativo que parte de los relatos en cuestión se llega finalmente a conclusiones de carácter estético e ideológico sobre los mismos.This article presents an analysis of some aspects of the relationship between cinematography and literature. Starting from the Don Quijote de La Mancha and taking into account some film and television versions developed in Spanish and English. At the beginning, a theoretical problem based on similar types for concepts categorization: author, narration, story, relat, among others will be analyzed. In addition, a connection is made with some authors' concepts in order to avoid textual ambiguity or multiple interpretations in the versions that are analyzed. Through a comparative analysis supported in these stories, it is possible to reach some aesthetic and ideological conclusions about them.

  6. Jasminum extensum Wall. ex G. Don (Oleaceace, a New Record to the Flora of Vietnam

    Directory of Open Access Journals (Sweden)

    Bui Hong Quang

    2013-06-01

    Full Text Available One rare, poorly known species from India, South China and Thailand - Jasminum extensum Wall. ex G. Don is recently discovered in Vietnam representing a new record to the flora of the country. The plant differs from its closely related species viz. Jasminum pierreanum in having coriaceous leaves and 5–6 primary veins in each side of the mid-rib. Detailed information on taxonomy, types, morphology, habitat, ecology, distribution and studied voucher specimens, as well as illustrations are provided here for species identification.

  7. The Knight-errant and their Itinerary. Journey and />Death of Don Quixote

    Directory of Open Access Journals (Sweden)

    Nieves Rodríguez Valle

    2016-01-01

    Full Text Available This article analyzes, from the perspective of the hero’s journey topic in the narrative, the wanderings of Don Quixote on the Spanish roads and in the spaces of the chivalric literature. Based on the four narrative sequences that stake out the itinerary in the journey narrative: departure, cruise, meeting, and return, the three departures and the three returns of the knight in the work are reviewed, specially the last return and the relationship that it keeps with his death.

  8. An Analysis of Insults in Don Quixote from the Perspective of Social History of Language

    Directory of Open Access Journals (Sweden)

    Jesús M. Usunáriz

    2017-11-01

    Full Text Available Daily use of insult, slander, in the societies of the Early Modern Age, is also present in the voices of the protagonists of Don Quixote. However, the Ingenious Gentleman and his squire, do not use the insult in the same way. This will depend on the social position of insulted and offender (noble or villain, and the circumstances surrounding it. However, social reality, collected in different court cases, shows that the insult did not respect, in the same way as in the novel, the stratified social structure.

  9. Juan Bautista Avalle Arce y el escrutinio de la librería de Don Quijote

    OpenAIRE

    Nállim, Carlos Orlando

    2000-01-01

    En este trabajo se destacan los aportes de Avalle Arce a la crítica del Quijote que lo convierten en el "cervantista actual por antonomasia". Se señalan sus grandes aciertos: la peculiar tesis del crítico acerca de la relación que se establece entre vida y literatura; la influencia en la vida de Don Quijote no sólo de los libros de caballería sino también de muchos otros que conformaban su abundante biblioteca; la solución que aporta al trillado tema cordura/locura del personaje...

  10. The invisible teenager: Comic book materiality and the amateur films of Don Glut

    Directory of Open Access Journals (Sweden)

    Matt Yockey

    2014-06-01

    Full Text Available Don Glut, between the ages of 9 and 25, made 41 short amateur films inspired by horror, science fiction, and superhero movies, serials, and comic books. The tactile qualities of comic books as affect-generating objects are instrumental to how Glut confirmed his identity during a time (adolescence in which that identity is particularly unstable. Glut used the popular figure of the teen rebel and his role as a filmmaker in order to negotiate with hegemonic restrictions on his objects of affection, especially comic books.

  11. De Tirso, Lorca y Shakespare al Litoral argentino: El Don Juan criollo de Leopoldo Marechal.

    OpenAIRE

    Marisa, Martínez Pérsico

    2012-01-01

    En el presente trabajo me propongo analizar la aplicación de uno de los procedimientos capitales del teatro de Leopoldo Marechal (1900-1970) como es la criollización de temas tradicionales, que adquieren así una doble dimensión, a la vez argentina y universal. El texto más conocido de su producción dramática donde se evidencia este recurso es Antígona Vélez (1951), como hipertexto criollo de la tragedia sofoclea. En esta oportunidad me concentraré en una pieza menos estudiada como es el Don J...

  12. Don DeLillo : une bibliographie sélective

    Directory of Open Access Journals (Sweden)

    Aaron Smith

    2006-03-01

    Full Text Available Oeuvres de Don DeLilloRomansAmericana. 1971. London : Penguin, 1990.End Zone. 1972. New York : Penguin, 1986.Great Jones Street. 1973. New York : Penguin, 1994.Ratner’s Star. 1976. London : Vintage, 1991.Players. 1977. London : Vintage, 1991.Running Dog. 1978. London : Picador, 1992.The Names. 1982. New York : Vintage, 1989.White Noise. 1984. London : Picador, 1985.Libra. 1988. London : Penguin, 1989.Mao II. 1991. London : Vintage, 1992.Underworld. 1997. New York : Scribner, 1997.The Body Art...

  13. Tolerances don't lie: or how to tolerance an optical system so that it works

    International Nuclear Information System (INIS)

    Fischer, R. E.

    2008-01-01

    There has been much written over the years about the generation of optical system fabrication, assembly, and alignment tolerances leading to a performance error budget and predicted system performance. Over my 40 years of optical design experience I have become more cautious (and concerned) about how accurately we, the optics community, are tolerancing our systems and predicting their manufactured performance. In this paper I will share with you some of these concerns along with recommended ways of avoiding the many speed bumps, pot holes and other common issues encountered when tolerancing. And of course I will reveal why tolerances don't lie

  14. Chemical Composition and Possible in Vitro Phytotoxic Activity of Helichrsyum italicum (Roth Don ssp. italicum

    Directory of Open Access Journals (Sweden)

    Vincenzo De Feo

    2011-09-01

    Full Text Available The chemical composition of the essential oil of Helichrysum italicum (Roth Don ssp. italicum, collected in the National Park of Cilento and Diano Valley, Southern Italy, was studied by means of GC and GC/MS. Forty four compounds of 45 constituents were identified in the oil, mainly oxygenated sesquiterpenes. The essential oil was evaluated for its potential in vitro phytotoxic activity against germination and early radicle elongation of radish and garden cress. The radicle elongation of radish was significantly inhibited at the highest doses tested, while germination of both seeds was not affected.

  15. Learning with Don Quixote for Children: the Presence of the Knight in Interactive Classrooms

    Directory of Open Access Journals (Sweden)

    Miriam Borham Puyal

    2015-05-01

    Full Text Available As a masterpiece, Don Quixote has become an iconic figure, owing to well-known episodes such as the tilting at windmills, which young readers already discover in editions of this classic for children. The present article provides an overview and assessment of the ways in which Spanish children have access to the text in an increasingly technological learning environment and how ICTs play a very important role in the ongoing popularity of Cervantes’ novel in the 21st century, as well as in the development of a form of education that goes beyond mere literacy by means of the approach to this text.

  16. Don Quixote goes to Hollywood: la reescritura del mito por Charles Chaplin

    OpenAIRE

    Bautista Naranjo, Esther

    2015-01-01

    El personaje de Charlot, creado por Charles Chaplin, traspone al cine mudo el mito de don Quijote. Unidos por el vínculo de la picaresca, ambos escenifican una dura crítica hacia la modernidad en sus diferentes estadios. Hay que distinguir el simple humorismo vodevilesco de Charlot en las breves tiras de 1914 de su configuración tragicómica desde algunos cortometrajes de 1915 hasta Modern Times (1936). Más allá de sus risibles apariencias físicas, y de sus disparatadas peripecias, subyacen en...

  17. El sistema preventivo de Don Bosco, respuesta a la escuela multicultural

    OpenAIRE

    Arenal Jorquera, María José

    2011-01-01

    El objetivo de este estudio es estudiar si el Sistema Preventivo de Don Bosco, que se lleva en todos los centros salesianos de los cinco continentes, da respuesta a la escuela multicultural actual. Y esto se produce como consecuencia de que las escuelas salesianas hacen realidad un medio escolar intercultural basado en el paradigma holístico, que se adapta al contexto de cada momento histórico en tiempo y espacio. El punto de partida del mencionado sistema educativo surge en la realidad s...

  18. The Landscape of Cervante´s Don Quixote: Orteguians Perspectives

    Directory of Open Access Journals (Sweden)

    Ángel Pérez Martínez

    2013-12-01

    Full Text Available Perspectival theory, related to Don Quixote by the many references in the corpus of Ortega, enables further research about the importance of the landscape and the physical description in order to understand the work of Cervantes. Similarly, it should be mentioned its relation with the development of literary theory. Such investigations give an interesting point of view under the framework called travel genre and its tangential contact with Quijote. On the other hand, and because of the publication of Obras Completas by Ortega, we find ourselves with a new order of the writings from the philosopher and an appropriate index for research.

  19. For the Amusement of the Merry Little Subjects: How British Children Met Don Quixote in the Long Eighteenth Century

    Directory of Open Access Journals (Sweden)

    Miriam Borham Puyal

    2015-12-01

    Full Text Available As a masterpiece, Don Quixote has become an easily recognizable myth, sometimes reduced to well-known episodes such as the tilting at windmills or the blanket-tossing of Sancho. These elements are emphasised in editions of this classic for children, highlighting the importance these versions have for the understanding of the widespread popularity of Cervantes’ novel, in general, and of certain scenes, in particular. The present article explores the relationship of the child reader to Don Quixote and provides an overview of how English children might have encountered it in the long eighteenth century (1660-1832. It connects chapbooks, abridgments and children’s books to suggest that children might have been among its earliest readers and to emphasise the intertextual continuum and the richness in the reception of Don Quixote in England, from the seventeenth to the nineteenth century.

  20. Don Quixote and the Exile: The representation of the Knight Hidalgo in the Plastic of the Aragonese Artist Eleuterio Blasco Ferrer

    Directory of Open Access Journals (Sweden)

    Rubén Pérez Moreno

    2014-12-01

    Full Text Available In the following article we are going to analyse the artworks of Don Quixote created in the exile by the Aragonese artist Eleuterio Blasco Ferrer (Foz-Calanda, Teruel, 1907-Alcañiz, Teruel, 1993. One of his sculptures, The last breath of Don Quixote, will reach high popularity, becoming a true symbol of the Republican exile.

  1. La teoría clásica del don y la donación de sangre

    Directory of Open Access Journals (Sweden)

    Casado Neira, David

    2003-04-01

    Full Text Available The Gift Theory exposed by Marcel Mauss is here used to analyze free, not paid and universal blood donation. According to Mauss, every gift involves three obligations: to give, to get and to return. All of them are present in modern blood donation, even gift is still in force as social exchange. But the gift of blood acquires some specific characteristics and, even when it does not follow the conventional patterns of a gift, it is not possible to obviate its validity. Some problems and conflicts generated under this biomedical practice would be understood if attention to the fuzzy persistence of the logic of gift were played, also in strongly institutionalized social contexts.

    La teoría del don enunciada por Marcel Mauss es en esta ocasión utilizada para analizar la donación de sangre (voluntaria, no remunerada y universal. Las tres obligaciones que implica el don (dar, recibir y devolver no están ausentes en la moderna donación de sangre, así como tampoco lo está la vigencia del don como forma de intercambio social; pero en la transfusión de sangre el don adquiere unas características específicas que, si bien no nos permite considerar esta donación como una forma convencional de don, tampoco es posible obviar su vigencia. Parte de los problemas y conflictos generados en torno a esta práctica biomédica no pueden ser comprendidos si no se presta atención a la difusa persistencia del don en contextos sociales fuertemente institucionalizados.

  2. The Fungicidal Activity of Tebuconazole Enantiomers against Fusarium graminearum and Its Selective Effect on DON Production under Different Conditions.

    Science.gov (United States)

    Diao, Xue; Han, Yiye; Liu, Chenglan

    2018-03-26

    Tebuconazole, which consists of a pair of enantiomers with different fungicidal activities, is one of the most common fungicides used in the control of Fusarium graminearum. In this study, the fungicidal activity of rac-tebuconazole and its enantiomers against F. graminearum was determined at 0.997, 0.975, and 0.950 a w and at 20, 25, and 30 °C on wheat-based media. Then, F. graminearum was treated with rac-tebuconazole and its enantiomers at the EC 10 , EC 50 , and EC 90 levels under different culture conditions, and DON production was measured. Finally, expression of the DON biosynthetic genes ( TRI5 and TRI6) was quantified by real-time RT-PCR after incubation with EC 50 doses of rac-tebuconazole and its enantiomers for 4, 8, and 14 days at 30 °C and a w 0.997. The results showed that the fungicidal activity of tebuconazole was strongly influenced by temperature, a w , and the combined factors. (-)-Tebuconazole is higher in fungicidal activity than (+)-tebuconazole and rac-tebuconazole with 24-99-fold and 1.8-6.7-fold, respectively. However, (-)-tebuconazole was generally more favorable for DON production than (+)-tebuconazole under the same conditions. Additionally, (-)-tebuconazole and rac-tebuconazole induced significantly increased expression of the DON biosynthetic genes ( TRI5 and TRI6) compared to the control by the 14th day of treatment. In this research, the combination condition of 30 °C and 0.997 a w is the most suitable for DON production by F. graminearum. The test strains of F. graminearum treated with the EC 10 dose of (-)-tebuconazole produced the greatest amounts of DON.

  3. Don Yllán and the Egyptian Sorcerer: Vernacular commonality and literary diversity in medieval Castile

    Directory of Open Access Journals (Sweden)

    Wacks, David A.

    2005-12-01

    Full Text Available In this article the author compares the exemplo of Don Yllán and the Deán de Santiago -no. 11 in Don Juan Manuel's Conde Lucanor (ca. 1335- with an earlier Hebrew analogue found in the Hebrew Mešal Haqadmonī (ca. 1285 of fellow Castilian author Isaac ibn Sahula. A thorough analysis of the rhetorical and narrative style of both versions reveals that the two tales shared a common source in Castilian oral tradition. The appearance of the tale in an earlier Hebrew text from Castile (the only other known version in any language calls into question the originality of Don Juan Manuel's most famous exemplo, suggesting a productive interplay between a common oral tradition in Castilian and coexisting literary traditions in Hebrew and Castilian.

    En este artículo, el autor compara el exemplo de Don Yllán y el Deán de Santiago -n.° 11 en el Conde Lucanor (ca. 1335 de Don Juan Manuel- con una versión anterior en la obra hebrea, Mešal Haqadmonī (ca. 1285 de otro autor castellano, Isaac ibn Sahula. Un análisis cuidadoso del estilo narrativo y retórico de ambas versiones revela que las dos comparten una fuente común en la tradición oral castellana. La aparición del cuento en un texto hebreo anterior de Castilla (la única versión conocida en cualquier otra lengua cuestiona la originalidad literaria del más famoso exemplo de Don Juan Manuel, y sugiere un intercambio productivo entre una tradición oral común castellana y tradiciones literarias hebreas y castellanas coexistentes.

  4. La visión fantasiosa/caballeresca de Don Quijote poco representada en la iconografía

    OpenAIRE

    Calabrese, Martín Ezequiel

    2017-01-01

    En el presente trabajo se analizará un aspecto un tanto curioso de la representación iconográfica del Quijote. En casi la totalidad de las ediciones de la obra se omite representar la “realidad” percibida por don Quijote, optando por graficar la representación realista de los hechos narrados. En los diferentes modelos iconográficos de las ediciones de la obra este aspecto es común, ya que ante el texto, la decisión habitual de los editores e ilustradores es mostrar a don Quijote como “es” den...

  5. Libros adquiridos por don Pedro Fermín de Vargas en sus viajes por las Antillas

    Directory of Open Access Journals (Sweden)

    Sergio Elías Ortíz

    1962-04-01

    Full Text Available Entre los papeles relacionados con la vida de Don Pedro Fermín de Vargas, que pueden consultarse en el Archivo General de Indias de Sevilla, hay una carta de él y una lista de libros que envía al Administrador de Correos de la Habana, Don José Fuertes, antiguo amigo suyo, luego su corresponsal y a la  vez espía de sus pasos para aprisionarlo, con el objeto de que se los guardase “en algún rincón de sus casa”.

  6. Beyond a pedagogical tool: 30 years of Molecular biology of the cell.

    Science.gov (United States)

    Serpente, Norberto

    2013-02-01

    In 1983, a bulky and profusely illustrated textbook on molecular and cell biology began to inhabit the shelves of university libraries worldwide. The effect of capturing the eyes and souls of biologists was immediate as the book provided them with a new and invigorating outlook on what cells are and what they do.

  7. The Live Universe. A Biologist's Perspective

    Science.gov (United States)

    Ferreira, Ricardo B.; Ferreira, João B.

    2017-09-01

    Astrobiology looks at all aspects related to life in places other than the Earth, including its biomolecular building blocks and suitable environmental conditions. In the present article, a different approach is followed: a comparative analysis between Astronomy and Biology as discrete domains of science. Remarkable similarities exist between these two apparently widely separated and multidisciplinary fields. Both are driven, from beginning to end, by thermodynamics. Their evolution is studied to a very reasonable degree of accuracy, from beginning to the present day, by analyzing data which were ‘frozen’ in the past. Yet we cannot predict where and how they will go from here. A major difference is that in Biology, unlike Astronomy, we can see and analyse the present (or, more accurately, the immediate past). While the Big Bang is widely accepted as the origin of our universe, the debate about its ultimate fate is far from settled. A plethora of cosmological models has been proposed, many involving the concept of a multiuniverse. The observation that the rate of expansion of the universe is apparently accelerating further boosts the discussion. Entropy may act as a driving force behind the increasing rate of expansion, with nothingness as the maximum possible entropy our universe gets. Using biological systems as an analogy and adopting a broad definition for life, we may speculate the existence of a living multiuniverse, capable of natural evolution, in which each individual universe spontaneously goes through birth, development, reproduction, ageing and death. The possible roles of supermassive black holes (SMBHs) and human-like intelligence on the future evolution of our universe are briefly discussed.

  8. Intelligent systems for the molecular biologist

    Energy Technology Data Exchange (ETDEWEB)

    Brutlag, D.L.

    1995-12-31

    This tutorial was one of eight tutorials selected to be presented at the Third International Conference on Intelligent Systems for Molecular Biology which was held in the United Kingdom from July 16 to 19, 1995. In this paper, one objective is to identify properties of DNA sequences that determine their function, by computer-aided statistical analysis and to accurately predict its function, given a new sequence. A related problem is to predict protein structure and function from the sequence.

  9. The Live Universe. A Biologist's Perspective

    Directory of Open Access Journals (Sweden)

    Ricardo B. Ferreira

    2017-09-01

    Full Text Available Astrobiology looks at all aspects related to life in places other than the Earth, including its biomolecular building blocks and suitable environmental conditions. In the present article, a different approach is followed: a comparative analysis between Astronomy and Biology as discrete domains of science. Remarkable similarities exist between these two apparently widely separated and multidisciplinary fields. Both are driven, from beginning to end, by thermodynamics. Their evolution is studied to a very reasonable degree of accuracy, from beginning to the present day, by analyzing data which were “frozen” in the past. Yet we cannot predict where and how they will go from here. A major difference is that in Biology, unlike Astronomy, we can see and analyse the present (or, more accurately, the immediate past. While the Big Bang is widely accepted as the origin of our universe, the debate about its ultimate fate is far from settled. A plethora of cosmological models has been proposed, many involving the concept of a multiuniverse. The observation that the rate of expansion of the universe is apparently accelerating further boosts the discussion. Entropy may act as a driving force behind the increasing rate of expansion, with nothingness as the maximum possible entropy our universe gets. Using biological systems as an analogy and adopting a broad definition for life, we may speculate the existence of a living multiuniverse, capable of natural evolution, in which each individual universe spontaneously goes through birth, development, reproduction, aging and death. The possible roles of supermassive black holes (SMBHs and human-like intelligence on the future evolution of our universe are briefly discussed.

  10. Ecfrasis literaria y arquitectura novelesca: Los cuadernos de don Rigoberto de Mario Vargas Llosa

    Directory of Open Access Journals (Sweden)

    Pedro Antonio Agudelo

    2013-07-01

    Full Text Available Este artículo propone una relectura de la novela Los cuadernos de don Rigoberto de Mario Vargas Llosa, concentrando la atención en la figura retórica de la ecfrasis. Examina la arquitectura novelesca y la representación verbal y visual como pilares de lo que constituiría una genuina novela iconoverbal. El estudio está soportado en las estrategias de análisis provenientes de la semiótica literaria, la narratología y la retórica, que permiten una comprensión amplia del objeto de estudio. This paper proposes a different interpretation of the novel Los cuadernos de don Rigoberto by Mario Vargas Llosa, focusing on the rhetorical figure of ekphrasis. It examines the novelistic architecture and verbal and visual representation as pillars of what would constitute a genuine iconoverbal novel. The study is supported by the analysis strategies from literary semiotics, narratology and rhetoric, which allow a comprehensive understanding of subject matter.

  11. 'Don't play the butter notes': jazz in medical education.

    Science.gov (United States)

    Bradner, Melissa; Harper, Darryl V; Ryan, Mark H; Vanderbilt, Allison A

    2016-01-01

    Jazz has influenced world music and culture globally - attesting to its universal truths of surviving, enduring, and triumphing over tragedy. This begs the question, what can we glean in medical education from this philosophy of jazz mentoring? Despite our training to understand disease and illness in branching logic diagrams, the human experience of illness is still best understood when told as a story. Stories like music have tempos, pauses, and silences. Often they are not linear but wrap around the past, future, and back to the present, frustrating the novice and the experienced clinician in documenting the history of present illness. The first mentoring lesson Hancock discusses is from a time he felt stuck with his playing - his sound was routine. Miles Davis told him in a low husky murmur, 'Don't play the butter notes'. In medical education, 'don't play the butter notes' suggests not undervaluing the metacognition and reflective aspects of medical training that need to be fostered during the early years of clinical teaching years.

  12. Homenaje a Don Gregorio Marañon en el Centenario de su Nacimiento

    Directory of Open Access Journals (Sweden)

    Fernando Serpa Florez

    1987-12-01

    Full Text Available

    La Academia Nacional de Medicina rinde homenaje hoy a un español universal, don Gregorio Marañón y Posadillo (1887-1960 en el primer centenario de su nacimiento. Se asocia a la admiración y al orgullo que este hombre despierta por su inteligencia, su sabiduría y su obra entre sus gentes de España, con el entrañable afecto que su nombre evoca entre nosotros los iberoamericanos que también, a nuestra manera, lo sentimos nuestro.

    Médico, historiador, escritor, humanista, sociólogo y maestro, su espíritu se ensoñoreó por los campos abiertos del saber, descollando con méritos señeros en cada una de estas disciplinas. Y si en el presente siglo su par en la medicina podría ser don Santiago Ramón y Cajal, en las letras don José Ortega y Gassety en las humanidades don Miguel de Unamuno, por su bucear en las aguas profundas y lustrales de la historia su nombre es parangonable con el de españoles eternos con los que equiparó su vida: un Séneca, por su austero interrogar al destino y por el doloroso regustar del destierro (“carere patria intolerabili est”. Un san Isidoro de Sevilla, por su ecumenismo. Un Garcilaso de la Vega, por su poético enamoramiento de Toledo. Un Maimónides, por las enseñanzas de su saber médico y por los discípulos dejados en las más diversas latitudes unido a su excepcional amplitud de criterio -rara flor en la patria de Ignacio de Loyolay de don Felipe 11-; ausencia de ese dogmatismo y fanatismo que el mismo “espejo de los caballeros” hubo de sublimar en las brumas de su locura para ser el arquetipo de lo español y de España. Y un Miguel Servet, en fin, por sus paralelas intuiciones científicas, las de éste en la circulación de la sangre pulmonar, las de don Gregario en la endocrinología, las hormonas y las muy sutiles investigaciones del hasta hace poco coto vedado de la sexología y los estados intersexuales.

    Corresponderá al distinguido representante de la Sociedad

  13. When Marcel Mauss's Essai sur le Don becomes The Gift: variations on the theme of solidarity.

    Science.gov (United States)

    Bateman, Simone

    2016-12-01

    Since the early 1970s, Marcel Mauss's Essai sur le Don (1923), translated into English as The Gift in 1954, has been a standard reference in the social science and bioethical literature on the use of human body parts and substances for medical and research purposes. At that time, three social scientists-political scientist Richard Titmuss in the United Kingdom and sociologist Renée C. Fox working with historian Judith Swazey in the United States-had the idea of using this concept to highlight the fundamental structure of the biomedical practices they were studying, respectively, blood donation, and hemodialysis and organ transplantation. The fact that these first applications of Mauss's essay should emerge in English- rather than in French-speaking countries raises the question of what the translation of the essay, and notably of the word don as gift, may have to do with this fact. Reading Mauss in translation undoubtedly inspired a seminal approach to interpreting medical and research practices based on bodily giving. This article posits that something may have also been lost: a much broader concept of giving with unquestionable links to the Durkheimian concept of solidarity, which Mauss conceptualizes not only as an obligation but also as a liberty to give.

  14. Don Quixote, Sweded by Michel Gondry in Be Kind Rewind (2008

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    Hogan Erin K.

    2017-12-01

    Full Text Available In the spirit of poetic license from Be Kind Rewind (2008, this article argues that Michel Gondry’s film “swedes,” its playful neologism for ersatz remaking of Hollywood and classic films, Miguel de Cervantes’s Don Quixote. The feature follows the Sanchification of Jerry (Jack Black, Gondry’s Don Quixote, and Quixotification of Mike (Mos Def, Gondry’s Sancho, as they nostalgically wrong cinematic rights through sweding and try to save their working-class neighbourhood from condemnation and gentrification through community film making. Gondry swedes the Quixote through his engagement with major themes and operations in Cervantes’s classic, including nostalgia, story-telling, conflicts between reality and fantasy, authorship, the grotesque and carnivalesque, (anti-heroes, race and gender-bending, genre, and addressees turned addressers. This article discusses Be Kind Rewind’s relationship to Hollywoodian and Cervantine classics through the theoretical frameworks of Julio Garcia Espinosa’s imperfect cinema and Foucauldian semiotics, respectively. Be Kind Rewind uses and abuses Hollywood stereotypes to re-purpose them for a critique of discriminatory practices. Where casting is concerned and where Michel’s characters diverge from Miguel’s, Be Kind Rewind advances that skin colour is not an arbitrary sign and that race has historical and contemporary meaning in intercultural interactions.

  15. [The virtue of that precious balsam...: approach to Don Quixote from the psychopharmacological perspective].

    Science.gov (United States)

    Lopez-Munoz, F; Garcia-Garcia, P; Alamo, C

    2007-01-01

    The most outstanding novel of the Spanish literature, Don Quixote, represents the source to which the different specialists who intend to deepen their knowledge of the late Renaissance society usually address. This masterpiece of Miguel de Cervantes has been frequently approached from the psychopathological perspective to obtain a psychiatric diagnosis of its main character, Alonso Quijano. Also, other clinical approaches from the traumatological and general therapeutical view (oils, ointments, balms and other pharmacy preparations) have been frequent. We have tackled Don Quixote from the psychopharmacological perspective, a barely explored field. In this work, we intend to study the therapeutical cures used during the Cervantine time for the treatment of insane and mentally disturbed people (sedatives like opium, laxatives like hellebore, tonics, irritants and surgical techniques like bloodlettings and ) and we analyze the limited and unspecific therapies, mainly of herbal origin (balms, purgatives and emetics), which Cervantes reveals to us in his novel. Among them, rhubarb root (Rumex alpinus), seeds of spurge (Euphorbia lathyris), St. John's Wort (Hypericum perforatum), main ingredient of Aparicio's oil, and rosemary (Rosmarinus officinalis), primary component of the famous balsam of Fierabras, should be highlighted. We have also examined the possible scientific influences which might have inspired Cervantes in this field, mainly the works of Juan Huarte de San Juan The examination of men's wits and the one of Andres Laguna Dioscorides' materia medica.

  16. Don Quixote, Machiavelli, and Robin Hood: public health practice, past and present.

    Science.gov (United States)

    Mullan, F

    2000-05-01

    Since the mid-19th century, when the first formal health departments were established in the United States, commissioners, directors, and secretaries of public health have functioned as senior members of the staffs of public executives, mayors, governors, and presidents. They have provided important political, managerial, and scientific leadership to agencies of government that have played increasingly important roles in national life, from the sanitary revolution of the 19th century to the prevention of HIV/AIDS and the control of tobacco use today. Although public health officials come from a variety of backgrounds and oversee agencies of varied size and composition, there are philosophical themes that describe and define the commonality of their work. These themes are captured metaphorically by 3 celebrated figures: Don Quixote, Machiavelli, and Robin Hood. By turns, the public health official functions as a determined idealist (Don Quixote), a cunning political strategist (Machiavelli), and an agent who redistributes resources from the wealthier sectors of society to the less well off (Robin Hood.) All 3 personae are important, but, it is argued, Robin Hood is the most endangered.

  17. Generation and analysis of expressed sequence tags from six developing xylem libraries in Pinus radiata D. Don

    Directory of Open Access Journals (Sweden)

    Dillon Shannon K

    2009-01-01

    Full Text Available Abstract Background Wood is a major renewable natural resource for the timber, fibre and bioenergy industry. Pinus radiata D. Don is the most important commercial plantation tree species in Australia and several other countries; however, genomic resources for this species are very limited in public databases. Our primary objective was to sequence a large number of expressed sequence tags (ESTs from genes involved in wood formation in radiata pine. Results Six developing xylem cDNA libraries were constructed from earlywood and latewood tissues sampled at juvenile (7 yrs, transition (11 yrs and mature (30 yrs ages, respectively. These xylem tissues represent six typical development stages in a rotation period of radiata pine. A total of 6,389 high quality ESTs were collected from 5,952 cDNA clones. Assembly of 5,952 ESTs from 5' end sequences generated 3,304 unigenes including 952 contigs and 2,352 singletons. About 97.0% of the 5,952 ESTs and 96.1% of the unigenes have matches in the UniProt and TIGR databases. Of the 3,174 unigenes with matches, 42.9% were not assigned GO (Gene Ontology terms and their functions are unknown or unclassified. More than half (52.1% of the 5,952 ESTs have matches in the Pfam database and represent 772 known protein families. About 18.0% of the 5,952 ESTs matched cell wall related genes in the MAIZEWALL database, representing all 18 categories, 91 of all 174 families and possibly 557 genes. Fifteen cell wall-related genes are ranked in the 30 most abundant genes, including CesA, tubulin, AGP, SAMS, actin, laccase, CCoAMT, MetE, phytocyanin, pectate lyase, cellulase, SuSy, expansin, chitinase and UDP-glucose dehydrogenase. Based on the PlantTFDB database 41 of the 64 transcription factor families in the poplar genome were identified as being involved in radiata pine wood formation. Comparative analysis of GO term abundance revealed a distinct transcriptome in juvenile earlywood formation compared to other stages of

  18. Effects of Pinus flexilis on the dynamics and structure of plant communities on the northern Rocky Mountain front, and, Training biologists for emerging niches in non-traditional jobs

    Science.gov (United States)

    Baumeister, Dayna Marie

    been characterized by invasion of P. flexilis and subsequent shifts in understory species composition apparently facilitated by P. flexilis. Lastly, I examined the role of the emerging science of biomimicry in providing employment for biologists. Biomimicry as a discipline seeks design solutions inspired by nature. Industries employing this tool require biologists with an understanding of biology from a functional perspective, good communication skills, and a background in applied natural history.

  19. Naturally occurrence of Sr and Ca in the stem of a Japanese cedar (Cryptomeria japonica D. Don) using PIXE

    International Nuclear Information System (INIS)

    Katayama, Y.; Aoki, T.; Ko, S.; Yoshida, K.

    2000-01-01

    Distribution profiles of Sr and Ca occurring naturally in the stem of a Japanese cedar (Cryptomeria japonica D. Don) were determined using PIXE. The average concentration of Sr was around 7.5 ppm and the average Ca concentration was about 540 ppm. (author)

  20. Social and Political Activization of the Don Nobility in the Early 20th Century and “Noble Liberalism”

    Directory of Open Access Journals (Sweden)

    Bratolyubova Mariya Viktorovna

    2014-03-01

    Full Text Available Peculiarity of the social, economic and legal status of the Don nobility influenced its political alertness and the opposition character of activity. The liberal wing supported the creation of a new world outlook system which was expected to provide the basis for transforming the political system by means of gradual transition to people’s representatives or constitutional form of government. The liberal landowners insisted on the introduction of zemstvo (district council, the solution of the Cossack issue; they strived for liberalization of the military and bureaucratic control of the Cossack troops and demanded the withdrawal of civil government agencies from the competence of the Military department. The liberal nobility actively supported the change of conditions of service for the Cossacks and pressed for easier draft obligation and releasing the Cossack troops from police duties which clashed with the military dignity. The conservative type of liberalism prevailed within the noble class of the DHR that distanced itself from both the left and the right political forces. The liberalism of the Don nobles was also a reflection of social and cultural peculiarities of the Cossacks. The social basis of the Don liberalism differed from the common Russian analogs. As the Cossack class was rather numerous at the Don, and its representatives made up quite an important part of the regional liberal corporation, they influenced its tactics and the political programming considerably.

  1. Get Thee Away, Knight, Be Gone, Cavalier: English Translations of the Biscayan Squire Episode in "Don Quixote de la Mancha"

    Science.gov (United States)

    Azevedo, Milton M.

    2009-01-01

    This article analyzes twelve English translations of the Biscayan squire's speech ("Don Quijote de la Mancha", Chapter Eight) published between 1612 and 2000. The solutions found fall into three categories, namely (a) using standard English and risking misrepresenting the style of the original and omitting relevant cultural connotations, (b) using…

  2. 13 CFR 123.510 - What if you don't use your Military Reservist EIDL funds as authorized?

    Science.gov (United States)

    2010-01-01

    ... Military Reservist EIDL funds as authorized? 123.510 Section 123.510 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION DISASTER LOAN PROGRAM Military Reservist Economic Injury Disaster Loans § 123.510 What if you don't use your Military Reservist EIDL funds as authorized? If your small business does not...

  3. The Socio-Political Attitudes of the Don Cossacks in the First Half of the 1920s

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    Olga V. Rvacheva

    2017-03-01

    Full Text Available The study of socio-political attitudes of the Don Cossacks in the early 1920s is of large importance for understanding the socio-political processes in the south of Russia at that time. After the Soviet power was established in the Don region, relations of mutual distrust formed between the Cossacks and the new power. The Soviet authorities viewed the Cossacks as a potentially counter-revolutionary force, though actual economic collapse and repressions from the state authorities considerably undermined the counter-revolutionary enthusiasm and brought social apathy among the Cossacks. Generally the sociopolitical attitudes of the Don Cossacks in 1920- 1922 can be described as follows. These were sporadic acts of disloyalty provoked primarily by the economic crisis and general social disruption in Cossack villages. By 1923 the situation had gradually changed. The economic growth contributed to a more positive attitude among Cossacks and peasants. The strengthening of the Soviet power, along with the policy of attention to peasants’ and Cossacks’ needs, made the Cossacks more loyal. They gradually got involved in the process of Soviet construction, took part in organization of the use of land, in elections to Soviet bodies, and so on. The article reveals the Don Cossacks’ attitudes in 1920-1924 and determines their causes, characteristics and changes under various factors.

  4. Small ships don't shine: classification of ocean vessels from low resolution, large swath area SAR acquisitions

    CSIR Research Space (South Africa)

    Meyer, Rory GV

    2016-07-01

    Full Text Available the Understanding of Our Living Planet, 10-15 July 2016, Beijing, China Small ships don't shine: Classification of ocean vessels from low resolution, large swath area SAR acquisitions R. G. V. Meyer ; W. Kleynhans ; C. P. Schwegmann Abstract: Monitoring...

  5. Sarmatian Monuments in the Forest-Steppe Interfluve Area Between the Don and the Volga Rivers (Zoning Experience

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    Berestnev Roman Sergeevich

    2015-06-01

    Full Text Available The article is devoted to the zoning of Sarmatian antiquities in the forest-steppe interfluve area between the Don and the Volga rivers. On the basis of the analysis, the authors allocate four areas of burial monuments in the Northern periphery of the Asian Sarmatia (the river in Voronezh, the Middle Don, the Upper Don, the area between the Khoper and the Volga rivers. The stages of the forest-steppe area development by the Sarmatians in the Don River, the Khoper river and the right bank of the Volga river were also studied. The first stage is characterized by the general description of Sarmatian monuments located in the forest-steppe area between the Volga and the Khoper. The authors carry out the detailed review of the distinctive features of the funeral rites and some peculiar details: stratigraphy, structures beneath barrows, forms of burial pits, postures of the deceased, orientation, use of fire, imported and domestic utensils, weapons and ornaments. Archaeological materials are compared with the data of ancient sources (Claudius Ptolemy. The result of the study consists in the comparative analysis of the binding of specific ethnic groups in the allocated areas. The authors attribute the Sarmatians on the Voronezh river with the Gippofagi ancient authors; the Aseyes and the Sakata – with the area of monuments in the forest between the Volga and the Khoper.

  6. The experience of strengthening subsidence of the soil under the existing building in the city of Rostov-on-Don

    Directory of Open Access Journals (Sweden)

    Prokopov Albert

    2017-01-01

    Full Text Available Described problem for multi-storey residential development in the city of Rostov-on-Don on collapsible soils. The analysis of the technical and technological peculiarities of solidification under conditions of maintained buildings. Examples of projects of consolidation subsidence of foundation soils of buildings in operation 50–70 years.

  7. 'Something deeper than things' : Some Artistic Influences on the Writing of Objects in the Fiction of Don DeLillo

    NARCIS (Netherlands)

    Jelfs, Timothy

    2011-01-01

    This article explores some of the artistic influences on the depiction of objects in Don DeLillo's fiction, from seventeenth-century Dutch still life painting to American Abstract Expressionism and Pop Art. It argues that the relationship between the depictions of objects encountered on the textual

  8. Enfermedad y muerte de Don Gonzalo Jiménez de Quesada

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    Fernando Serpa Florez

    1997-12-01

    Full Text Available

    La lepra es una enfermedad que se caracteriza por la insidia de su presencia, su lenta evolución y la progresiva incapacidad que en sus víctimas causa.

    Esto y el temor que ha infundido desde tiempos bíblicos, han hecho que ante ella se haya mantenido una actitud ambivalente de negación hasta donde es posible y de rechazo irracional a quien la padece, por temor al contagio.

    Ejemplo de ello es el aura de sagrado misterio que envuelve la leyenda de los padecimientos del Adelantado don Gonzalo Jiménez de Quesada (1509-1579, conquistador del Nuevo Reino de Granada y fundador de Santafé de Bogotá en el año de 1538, muerto a la edad, avanzada para la época, de setenta años.

    No se puede afirmar, en forma definitiva, que el conquistador fuera leproso. Se acepta, acogiendo el argumento de autoridad que tiene el primer historiador médico entre nosotros, don Pedro María Ibáñez, quien escribió en 1884, en las Memorias para la Historia de la Medicina en Santa Fe, que en “1579 falleció en la ciudad de Mariquita, y de mal de lepra o elefancía de los

    Coincide ello con lo que consigna don José María Vergara y Vergara en su Cuadro Cronológico de la Nueva Granada (hoi Estados Unidos de Colombia, desde los cipas hasta nuestros días (se ha conservado la ortografía usada a mediados del siglo XIX, preconizada por don Andrés Bello, estudio publicado en 1866, en que informa que a poco de posesionarse el tercer Presidente del Nuevo Reino, don Lope Díez Aux de Armendáriz: “ocurrió la muerte del adelantado Gonzalo Jiménez de Quesada que tuvo lugar en Mariquita el 16 de febrero de 1579, a la edad de ochenta años no cumplidos (sic, i de enfermedad de lepra (…” (2.

    Estos conceptos fueron debatidos por contemporáneos de Vergara y de Ibáñez como el doctor Juan de Dios Carrasquilla aduciendo, entre otros argumentos, que la lepra no fue mencionada por los coetáneos del conquistador. Y que la sífilis, com

  9. Effects of feeding deoxynivalenol (DON)-contaminated wheat to laying hens and roosters of different genetic background on the reproductive performance and health of the newly hatched chicks.

    Science.gov (United States)

    Ebrahem, Mohammad; Kersten, Susanne; Valenta, Hana; Breves, Gerhard; Beineke, Andreas; Hermeyer, Kathrin; Dänicke, Sven

    2014-08-01

    A total of 216 23-week-old laying hens from two different genetic backgrounds (half of the birds were Lohmann brown [LB] and [LSL] hens, respectively) and 24 adult roosters were assigned to a feeding trial to study the effect of increasing concentrations of deoxynivalenol (DON) in the diet (0, 5, 10 mg/kg) on the reproductive performance of hens and roosters, and the health of the newly hatched chicks. Hatchability was adversely affected by the presence of DON in LB hens' diet, while the hatchability of the LSL chicks was significantly higher than LB chicks. An interaction effect between DON in the hens' diet and the breed was noticed on fertility, as the fertility was decreased in the eggs of LB hens receiving 10 mg/kg DON in their diet and increased in the eggs of LSL hens fed 10 mg/kg DON. Moreover, spleen relative weight was significantly decreased in the chicks hatched from eggs of hens fed contaminated diets, while gizzard relative weight was significantly decreased in LB chicks with 10 mg/kg DON in their diet compared with the control group. On the other hand, the chicks' haematology and organ histopathology were not affected by the dietary treatment. Additionally, the presence of DON in the roosters' diet had no effect on fertility (the percentage of fertile eggs of all laid eggs). Consequently, the current results indicate a negative impact of DON in LB hens' diet on fertility and hatchability, indicating that the breed of the hens seems to be an additional factor influencing the effect of DON on reproductive performance of the laying hens.

  10. The effect of feeding a diet naturally contaminated with deoxynivalenol (DON) and zearalenone (ZON) on the spleen and liver of sow and fetus from day 35 to 70 of gestation.

    Science.gov (United States)

    Tiemann, U; Brüssow, K-P; Dannenberger, D; Jonas, L; Pöhland, R; Jäger, K; Dänicke, S; Hagemann, E

    2008-07-10

    Pregnant sows were fed a control diet (CON, 0.15 mg deoxynivalenol (DON) and 0.0035 mg zearalenone (ZON) per kg diet) or diet containing 15% of Fusarium toxin contaminated triticale (MYCO, 4.42 mg DON and 0.048 mg ZON per kg diet) during days 35-70 of gestation. All sows were fed in a restricted feeding regimen with the same amount of feed (2000 g/d) over the whole study. At the end of the experiment, fetuses were delivered by Caesarian section and samples of spleen and liver of euthanized sows and fetuses were analyzed. At terminal necropsy, no macroscopic lesion was observed in any organ of either sows or fetuses. The histopathological data indicated significant alteration only in elevated iron staining in the red pulp of spleens in sows of MYCO group after 35 days of feeding. The presence of hemosiderin particles in the spleen sections was confirmed by transmission electron microscopical investigation and by an enhanced Fe2+ concentration in spleen. A glycogen increase (p<0.05) was found in liver cells of fetuses in the experimental group. Together, the results provide evidence of spleen dysfunction (hemosiderosis) in sows fed a Fusarium toxin-contaminated wheat, however, with absence of clinical signs. Enhanced glycogen and an impairment of mitochondria in liver of fetuses was present when their mothers consumed the MYCO diet.

  11. OxDONS syndrome: the inevitable disease of the NHS reforms.

    Science.gov (United States)

    Adams, C. B.

    1995-01-01

    The financial demise of Oxford's department of neurosurgery (OxDONS) was precipitated by the financial rules of the reformed NHS. In particular it was produced by the failure of "resources to follow patients"; the requirement that "prices have to follow costs"; and the use of private income for revenue expenditure, not capital expenditure. This process will eventually affect all hospital departments, but it affected the unit in Oxford sooner as it started as "efficient"--that is, underresourced--and has depended on income from extracontractual referrals and private work. Current NHS accounting rules act as a disincentive to private income being generated in NHS hospitals, and consultants should be aware of this. PMID:8520404

  12. A phantom extinction? New insights into extinction dynamics of the Don-hare Lepus tanaiticus.

    Science.gov (United States)

    Prost, S; Knapp, M; Flemmig, J; Hufthammer, A K; Kosintsev, P; Stiller, M; Hofreiter, M

    2010-09-01

    The Pleistocene to Holocene transition was accompanied by a worldwide extinction event affecting numerous mammalian species. Several species such as the woolly mammoth and the giant deer survived this extinction wave, only to go extinct a few thousand years later during the Holocene. Another example for such a Holocene extinction is the Don-hare, Lepus tanaiticus, which inhabited the Russian plains during the late glacial. After being slowly replaced by the extant mountain hare (Lepus timidus), it eventually went extinct during the middle Holocene. Here, we report the phylogenetic relationship of L. tanaiticus and L. timidus based on a 339-basepair (bp) fragment of the mitochondrial D-loop. Phylogenetic tree- and network reconstructions do not support L. tanaiticus and L. timidus being different species. Rather, we suggest that the two taxa represent different morphotypes of a single species and the extinction of 'L. tanaiticus' represents the disappearance of a local morphotype rather than the extinction of a species.

  13. War as Haiku: The Politics of Don DeLillo’s Late Style

    Directory of Open Access Journals (Sweden)

    Matthew Shipe

    2016-05-01

    Full Text Available In the wake of 'Underworld' (1997, Don DeLillo’s work has been cast largely in a minor key. In this essay, I will focus on 'Point Omega', the work that I believe most clearly illuminates the political implications of DeLillo’s late style as it tackles the consequences of the wars in Afghanistan and Iraq. More broadly, I hope to connect 'Point Omega' to the work of DeLillo’s contemporaries that have also speculated on the historical and political implications of the War on Terror. Centering on 'Point Omega', I am interested in how DeLillo has adopted a distinctive narrative form in his most recent fiction that frequently unsettles and complicates the historical narratives that he had established in his earlier work.

  14. Removal and recovery of uranium by modified Pinus radiata D. Don Bark

    Energy Technology Data Exchange (ETDEWEB)

    Freer, J.; Baeza, J.; Maturana, H.; Palma, G.; Duran, N.

    1989-01-01

    Bark from Pinus radiata D. Don was treated with both sulfuric acid/formaldehyde and nitric acid/formaldehyde. The ability to adsorb uranium by the bark was improved by these treatments, with essentially zero bleed colour into solution. The resin produced by nitric acid/formaldehyde treatment showed, in general, a better retention capacity than that of sulfuric acid/formaldehyde treatment. The nitric acid/formaldehyde modified bark showed 96% of adsorption of uranium after 1h and 63% of desorption from the loaded resin after 3h in 0.5M sulfuric acid solution. Unmodified bark and some bark components were also analyzed. Bark was shown to be an excellent adsorber, comparable in efficiency, but costing less than the commercial adsorbing agents. (author).

  15. La Locura y el Buen Sentir de Don Quijote de la Mancha.

    Directory of Open Access Journals (Sweden)

    Adolfo de Francisco Zea

    2005-10-01

    La identidad de Alonso Quijano fue trazada borrosamente por Cervantes en la primera parte de su magistral novela. Tan sólo representa la imagen de uno de tantos hidalgos de una aldea española del siglo XVI: un hombre sencillo, bueno por antonomasia, “de complexión recia, seco de carnes, enjuto de rostro, gran madrugador y amigo de la caza”, y un lector fervoroso en sus horas de ocio y hastío que sólo llega a alcanzar con plenitud su identidad absoluta cuando tiene el vigor de transformarse en caballero andante de otros tiempos, en el Caballero de la Triste Figura como le llamó Sancho, en el valiente Caballero de la aventura de los leones, o simplemente en Don Quijote...

  16. El don del agua, una obligacion moral y un interes de reconocimiento

    Directory of Open Access Journals (Sweden)

    Ana Patricia Quintana Ramírez

    2015-01-01

    Full Text Available En este artículo se presenta una discusión teórica en torno al análisis de la naturaleza y el interés de la economía del obsequio, así como el significado que tiene la práctica de donar agua en la sociedad.   Mediante el contraste argumentos y la referenciación de algunos casos empíricos, se concluye que el don del agua es una obligación moral en la esfera interpersonal, con un interés de acceso al reconocimiento social entre grupos humanos marginados del acceso al recurso. 

  17. Don Quijote goes to Hollywood: The rewrite of myth by Charles Chaplin

    Directory of Open Access Journals (Sweden)

    Esther Bautista Naranjo

    2015-12-01

    Full Text Available The character of Charlot, created by Charles Chaplin, rewrites the myth of don Quixote in silent movies. While sharing the roots of the picaresque tradition, they represent a harsh criticism of modernity in all its stages. A distinction has to be made between the plain vaudevillesque humor of Charlot in the brief comic strips from 1914 and its tragi-comical shaping in some short films from 1915 up to Modern Times (1936. Beyond their mere physical aspects and their hilarious exploits, an underlying tragic heroism and idealism lead them to uphold all good causes and to support the wronged ones while they also struggle for survival. Charlot combines the comic with the sublime and, as well as the ingenious hidalgo, his soul becomes gradually fuller, deeper and more human. For all these reasons, this character could be regarded as a “quixote” of the big screen.

  18. [Age dynamics of population gene pool of the Crimean pine (Pinus pallasiana D. Don) in Crimea].

    Science.gov (United States)

    Korshikov, I I; Mudrik, E A; Krasnoshtan, O V; Velikorid'ko, T I; Kalafat, L A; Podgornyĭ, D Iu

    2011-01-01

    Polymorphism of young (14-16 years), middle-aged (70-80 years) and old (120-150 years) plants and their seed embryos has been studied using 20 and 10 allozyme loci correspondingly in the population of Pinus pallasiana D. Don from Mountain Crimea. It was revealed that the old-aged trees had significantly lower level of expected heterozygosity than the young plants. The level of observed heterozygosity of embryos of the uneven-aged plants was slightly different among the embryo samples and significantly lower than in the samples of maternal trees. Supernumerary homozygotation of the embryos is caused by low level of cross-pollination in three studied samples of plants (t(m) = 0,537-0,637).

  19. Haplophyllum linifolium (L. G. Don fil: EAEn arriskuan dagoen landarearen kontserbazioa.

    Directory of Open Access Journals (Sweden)

    Asier Jáñez

    2017-01-01

    Full Text Available Haplophyllum linifolium (L. G. Don fil. Iberiar Penintsulako endemismoa da, Euskal Autonomia Erkidegoko flora mehatxatuaren zerrendan galtzeko arriskuan bezala katalogatzen dena. Ikerketa honen helburuak izan dira, batetik espezie honen hozidura protokoloak lortzea eta, bestetik, espezie horren hazien bideragarritasuna ikustea Tetrazolio Testaren bitartez. Horiek egitea ezinbestekoa zen espezie honen ex situ kontserbaziorako, baita landarearen hazkuntza egiteko ere etorkizunean in situ kontserbazio ekintzak egiteko, kasurako populazio indarketak. Alde batetik, lortutako hazien bideragarritasuna %64koa izan zen. Bestalde, hozidura protokolo egokienak zehaztu ziren, emaitzen analisi estatistikoa eginez R softwarearen bitartez, erregresio binomial logistikoaren ereduan oinarrituz. Lortutako hozidurak %43 eta %45 bitartekoak izan ziren, estratifikazio hotza (4ºC, 60 egun egin ondoren, ikasitako lau baldintzetan: 15ºC, 20ºC, 20/10ºC eta 25ºC, 12/12 ordu argi/iluntasun fotoperiodoekin.

  20. Service quality improvement of ground staff at Don Mueang International Airport

    Directory of Open Access Journals (Sweden)

    Sittichai Sricharoenpramong

    2018-01-01

    Full Text Available The purposes of this research were to: 1 evaluate the service quality of the ground staff at Don Mueang International Airport (DMK, 2 compare the ground staff quality service perception of Thai passengers at DMK, and 3 provide guidelines for service quality improvement of the DMK airlines ground staff. A sample size of 400 Thai domestic passengers was accidentally selected at DMK. A questionnaire was used as a research tool for data collection. Five dimensions of service quality were evaluated: reliability, responsiveness, assurance, empathy, and tangibles. It was found that the service quality of ground staff was moderate. The highest dimension of service quality realization was tangibles, followed successively by reliability, assurance, empathy, and responsiveness. The passengers' perception of the ground staff's service quality varied by gender and age group. Guidelines were proposed for the improvement of ground staff service quality at DMK based on the findings. Keywords: airport, ground staff, quality of service

  1. Orthodox Revival in the Lower Volga Area and the Don in 1942–1943

    Directory of Open Access Journals (Sweden)

    Mordvinov Sergey Valeryevich

    2013-02-01

    Full Text Available The paper shows the impact of the Battle of Stalingrad in the revival of Orthodoxy in the Lower Volga and the Don, a comparison of the reconstruction process in the dioceses of the region; its characteristics are revealed in Stalingrad, Saratov, Astrakhan and Rostov regions. The author comes to the conclusion that the battle of Stalingrad was the catalyst recovery Orthodoxy in the province. The pace of discovery of temples was higher in the occupied areas of the Rostov and Stalingrad areas than in front-line areas. Imbalance in the number of active parishes continued to persist after the end of the Battle of Stalingrad. Church patriotic charity in 1942–1943 was the most active in the Saratov and Stalingrad diocese.

  2. Don Juan-Fracture” as a Hint to Aortic Isthmus Rupture

    Directory of Open Access Journals (Sweden)

    Sirilak Suksompong

    2014-01-01

    Full Text Available We report a case of thoracic aortic rupture after blunt trauma in a 23-year-old male patient. The initial investigation found no external injury or bleeding, only a slightly widened mediastinum and a broken left calcaneus. Abdominal lavage was negative, biochemistry was normal, and breathing and oxygenation were not compromised. When changing his position during diagnostics, the patient all of a sudden developed cardiac arrest and typical signs of hypovolemic shock. An immediate sternotomy was done without any further diagnostics on suspicion of aortic isthmus injury. A circular avulsion at the ligamentum arteriosum was found as assumed and repaired under cardiopulmonary bypass. The patient left the hospital for rehabilitation after 12 days in adequate health status. Biodynamics of blunt trauma after high-speed frontal impact and the relationship between calcaneus fracture, called “Don-Juan fracture,” and aortic rupture at the site of ligamentum arteriosum are discussed.

  3. The Secret List of Dos and Don'ts for Filmmaking

    Science.gov (United States)

    Kramer, N.

    2012-12-01

    Science is a massive black box to billions of people who walk the streets. However, the process of filmmaking can be equally as mystifying. As with the development of many scientific experiments, the process starts on a napkin at a restaurant…but then what? The road to scientific publication is propelled by a canonical list of several dos and don't that fit most situations. An equally useful list exists for up-and-coming producers. The list streamlines efforts, optimizes your use of the tools at your fingertips and enhances impact. Many fundamentals can be learned from books, but during this talk we will project and discuss several examples of best practices, from honing a story, to identifying audience appeal, filming, editing and the secrets of inexpensively acquiring expert help. Whether your goal is a two-minute webisode or a 90 minute documentary, these time-tested practices, with a little awareness, can give life to your films.;

  4. Size, Albedo, and Taxonomy of the Don Quijote Space Mission Target

    Science.gov (United States)

    Harris, Alan; Mueller, Michael; Fitzsimmons, Alan

    2006-03-01

    Rendezvous and lander missions are a very effective but very expensive way of investigating Solar-System bodies. The planning, optimization and success of space missions depends crucially on prior remotely-sensed knowledge of target bodies. Near-Earth asteroids (NEAs), which are mainly fragments of main-belt asteroids, are seen as important goals for investigation by space missions, mainly due to the role their forebears played in planet formation and the evolution of the Solar System, but also for the pragmatic reason that these objects can collide with the Earth with potentially devastating consequences. The European Space Agency is currently planning the Don Quijote mission to a NEA, which includes a rendezvous (and perhaps a lander) spacecraft and an impactor vehicle. The aim is to study the physical properties of the target asteroid and the effects of the impact on its dynamical state, as a first step in considering realistic mitigation measures against an eventual hazardous NEA. Two potential targets have been selected for the mission, the preferred one being (10302) 1989 ML, which is energetically easier to reach and is possibly a scientifically interesting primitive asteroid. However, due to the ambiguity of available spectral data, it is currently not possible to confidently determine the taxonomic type and mineralogy of this object. Crucially, the albedo is uncertain by a factor of 10, which leads to large uncertainties in the size and mass and hence the planned near-surface operations of Don Quijote. Thermal-infrared observations are urgently required for accurate size and albedo determination. These observations, which can only be carried out by Spitzer and would require only a modest amount of observing time, would enable an accurate diameter to be derived for the first time and the resulting albedo would remove the taxonomic ambiguity. The proposed Spitzer observations are critical for effective mission planning and would greatly increase our

  5. «Red Ritualism» in the Territory of Don Oblast in 1923-1924

    Directory of Open Access Journals (Sweden)

    Tabunshchikova Liudmila

    2015-12-01

    Full Text Available The birth, development and extinction peculiarities of the “Red Ritualism” (new traditions and rituals of Soviet Russia in the territory of Don Oblast in 1923–1924 are considered in this article on the basis of the regional periodicals of 1920. The Soviet Government was interested in new ritualism from the first revolution years till the beginning of 1930 and in the period of the Khrushchev Thaw (the end of the 1950 — the beginning of the 1960 . The article is devoted to the investigation of theses processes at the regional level in the first half-year of the 1920. The struggle with survives of time was on of the most evident areas of the anti-religious activity of the Goverment in the fi rst half-year of the 1920 th. After the company of church values confiscation the Government stroke an ideological blow at the way of life — they created “civil funeral”, “red marriage” and “octyabriny” (a name-day, the soviet ritual as an alternative of christening. In the Don region theses rituals appeared in 1923. “The red christening” was the most popular, “the civil funeral” was the least one. These processes were mostly spread in the cities and in a less degree in the villages. While in the whole country in 1925 the interest toward the “red ritualism” reached the peak, in the Donskaya oblast it was fading away. The author in this work uses the archive materials that were not published previously. The article will be useful for the specialists and other people interested in the given subject.

  6. Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetylated derivatives in intestinal epithelial cells.

    Science.gov (United States)

    Alassane-Kpembi, Imourana; Puel, Olivier; Oswald, Isabelle P

    2015-08-01

    In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly sensitive to mycotoxins. The aim of this study was to investigate the effects of deoxynivalenol (DON) and four other type B trichothecenes (TCTB), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV) and fusarenon-X (FX) alone or in combination on intestinal epithelial cells. Proliferating, non-transformed IPEC-1 cells were exposed to increasing doses of TCTB, alone or in binary mixtures and mycotoxin-induced cytotoxicity was measured with MTT test. The toxicological interactions were assessed using the isobologram-Combination index method. The five tested mycotoxins and their mixtures had a dose-dependent effect on the proliferating enterocytes. DON-NIV, DON-15-ADON and 15-ADON-3-ADON combinations were synergistic, with magnitude of synergy for 10 % cytotoxicity ranging from 2 to 7. The association between DON and 3-ADON also demonstrated a synergy but only at high doses, at lower doses antagonism was noted. Additivity was observed between NIV and FX, and antagonism between DON and FX. These results indicate that the simultaneous presence of mycotoxins in food commodities and diet may be more toxic than predicted from the mycotoxins alone. This synergy should be taken into account considering the frequent co-occurrence of TCTB in the diet.

  7. Integrins and epithelial cell polarity.

    Science.gov (United States)

    Lee, Jessica L; Streuli, Charles H

    2014-08-01

    Cell polarity is characterised by differences in structure, composition and function between at least two poles of a cell. In epithelial cells, these spatial differences allow for the formation of defined apical and basal membranes. It has been increasingly recognised that cell-matrix interactions and integrins play an essential role in creating epithelial cell polarity, although key gaps in our knowledge remain. This Commentary will discuss the mounting evidence for the role of integrins in polarising epithelial cells. We build a model in which both inside-out signals to polarise basement membrane assembly at the basal surface, and outside-in signals to control microtubule apical-basal orientation and vesicular trafficking are required for establishing and maintaining the orientation of epithelial cell polarity. Finally, we discuss the relevance of the basal integrin polarity axis to cancer. This article is part of a Minifocus on Establishing polarity. © 2014. Published by The Company of Biologists Ltd.

  8. Design of a Self Don/Doffing Rear Entry Planetary Suit to Interface with a Suit Port/Lock, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Under Phase 1 of subject SBIR, Air-Lock, Incorporated will design a self donning and doffing Rear Entry Hard Upper Torso (REHUT) that interfaces with a suit port....

  9. The "don't eat me" signal CD47 is a novel diagnostic biomarker and potential therapeutic target for diffuse malignant mesothelioma.

    Science.gov (United States)

    Schürch, Christian M; Forster, Stefan; Brühl, Frido; Yang, Sara H; Felley-Bosco, Emanuela; Hewer, Ekkehard

    2017-01-01

    Diffuse malignant mesothelioma (DMM) is one of the prognostically most discouraging cancers with median survivals of only 12-22 months. Due to its insidious onset and delayed detection, DMM is often at an advanced stage at diagnosis and is considered incurable. Combined chemo- and radiotherapy followed by surgery only marginally affect outcome at the cost of significant morbidity. Because of the long time period between exposure to asbestos and disease onset, the incidence of DMM is still rising and predicted to peak around 2020. Novel markers for the reliable diagnosis of DMM in body cavity effusion specimens as well as more effective, targeted therapies are urgently needed. Here, we show that the "don't eat me" signalling molecule CD47, which inhibits phagocytosis by binding to signal regulatory protein α on macrophages, is overexpressed in DMM cells. A two-marker panel of high CD47 expression and BRCA1-associated protein 1 (BAP-1) deficiency had a sensitivity of 78% and specificity of 100% in discriminating DMM tumour cells from reactive mesothelial cells in effusions, which is superior to the currently used four-marker combination of BAP-1, glucose transporter type 1, epithelial membrane antigen and desmin. In addition, blocking CD47 inhibited growth and promoted phagocytosis of DMM cell lines by macrophages in vitro . Furthermore, DMM tumours in surgical specimens from patients as well as in a mouse DMM model expressed high levels of CD47 and were heavily infiltrated by macrophages. Our study demonstrates that CD47 is an accurate novel diagnostic DMM biomarker and that blocking CD47 may represent a promising therapeutic strategy for DMM.

  10. Diseño del código de convivencia para el Colegio Técnico Salesiano Don Bosco - Kennedy

    OpenAIRE

    Aguilar Acosta, Andrea Anabel; Puga Reyes, Denis Gicela

    2013-01-01

    The Coexistence’s Code delivered to The Don Bosco Technical Salesian High School, is an instrument that is going to work as moral and ethical framework to govern and regulate relationships between each member of the educational community so that they can achieved institutional objectives presents in Institutional Educational Project. El presente Código de Convivencia entregado al Colegio Técnico Salesiano “Don Bosco” – Kennedy; es un instrumento que funcionara como marco referencial, moral...

  11. The Discoveries and Achievements of Modern Historiography of the Don Cossacks in the Second Half of the XIX Century

    Directory of Open Access Journals (Sweden)

    Oleg E. Chuikov

    2016-09-01

    Full Text Available The article examines the current historiography of the Don Cossacks in the second half of the XIX century, there is described the traditional and the alternative concepts advanced by historians after 2000 year. The article analyses the main studies on this chronological period, their advantages and disadvantages. It is shown that many of the events and reforms are not sufficiently understood so far. The authors note that the increase in the number of specialists on Don history of 1860–1890 should be considered the major trend in the development of modern historiography of this period, and it is hoped that the range of the studied issues will only expand in the future, and the level and number of publications revealing new facts and offering new concepts will continue to grow.

  12. Don Quixote and the Auditor from México: a disagreement between a knight and a gentleman

    Directory of Open Access Journals (Sweden)

    María Eugenia Mayer

    2009-12-01

    Full Text Available Don Quixote’s first adventure, the combat with the Basque, and his last one, in which he meets the Auditor, both deal with a «knight»/gentleman who is leaving for the West Indies. The opposite pole of the Manchego knight is the gentleman appointed to the Audience of New Spain, ca. 1600, during Lerma’s Privacy. This lawyer/auditor hears two «cases»: the «strange humor» of the Manchegan, as told by the priest who has found an anonymous manuscript; and the «unnexpected business» of his future son-in-law, who will accompany him to Mexico, heir to a title. The Oidor’s discreet proceedings contrast with Don Quixote’s open proclaims, thus serving as key to a bicostal (Spain/Indies reading of the

  13. Mitigation-relevant science with Don Quijote - a European-led mission to a near-Earth asteroid

    Science.gov (United States)

    Harris, A. W.; Galvez, A.; Benz, W.; Fitzsimmons, A.; Green, S. F.; Michel, P.; Valsecchi, G.; Paetzold, M.; Haeusler, B.; Carnelli, I.

    The Don Quijote concept includes a rendezvous spacecraft and an impactor vehicle The main aim of the mission is to carry out an experiment to demonstrate the modification of a near-Earth asteroid s orbit in a controlled way as a first step in establishing mitigation measures against an eventual hazardous object In particular the spacecraft would study the physical properties of the target asteroid and the effects of a kinetic impact on its dynamical state It is also expected that some spacecraft resources will be available for more general solar-system science investigations The Don Quijote mission is currently at the phase-A stage during which a number of European consortia of industrial and scientific partners will study its technical feasibility and potential scientific return The basic mission concept current scientific issues and the possibilities for international participation in the mission will be discussed

  14. What is the Word at Logos College? Homosocial ritual or homosexual denial in Don Delillo's End Zone?

    Science.gov (United States)

    Hardin, M

    2000-01-01

    "What Is the Word at Logos College? Homosocial Ritual or Homosexual Denial in Don Delillo's End Zone?" investigates the homoerotic desire that, despite being culturally repressed, periodically surfaces in foothall. Given the highly closeted nature of American foothall, it is necessary to look at the puns, allusions, and interactions between the players to see how Don DeLillo has created a text that subtly exposes the homoerotics of male sport. In order to strengthen the connection between homoeroticism and football, I will show how football's invention and organization in America coincides with the construction of the homosexual subject. Football and other arenas for male-male play become enforced at the same time as desire begins to express itself; thus, football is the logical place in America to look for unresolved (and resolved) male homosexuality, and DeLillo does this skillfully.

  15. Dostoyevski y Don Quijote: poética y estética de una ilusión

    OpenAIRE

    Djermanovic, Tamara

    2015-01-01

    En la obra de Fiódor Mijáilovich Dostoyevski (1821-1881) se encuentran más de treinta referencias a Don Quijote; algunas hablan de Don Quijote como novela, otras hacen referencia al héroe de Cervantes como figura arquetípica. El quijotismo ruso, donde la obra de Dostoyevski es un eslabón importante, ha llamado el interés de la crítica literaria rusa desde hace décadas y en los últimos años se han publicado estudios importantes sobre el tema. La investigación señala cómo a través de las refere...

  16. Emouvoir et persuader pour promouvoir le don d'organes ? : l'efficacité entre éthique et droit

    OpenAIRE

    Flueckiger, Alexandre

    2010-01-01

    Chaque année, des patients décèdent faute d'organes disponibles pour une transplantation. Chacun étant libre de donner ou non ses organes pour le bien d'autrui, l'Etat ne saurait juridiquement contraindre ses concitoyens à faire don d'une partie de leur corps, tant de leur vivant qu'après leur mort. La liberté n'étant pas absolue, la sauvegarde de la santé et de la vie des receveurs potentiels justifie pourtant de mettre sur pied des mesures de promotion du don d'organes à l'attention de la p...

  17. Condition and Organization of Everyday Life in the Military Units of the Southwestern, Stalingrad and Don fronts (1942–1943

    Directory of Open Access Journals (Sweden)

    Tatiana P. Khlynina

    2015-03-01

    Full Text Available The article is devoted to various aspects of the condition and organization of the everyday life of military units of the Southwestern, Stalingrad and Don fronts in 1942–1943 years. The looks of the questions of food and clothing supplies, ensure domestic needs and recreation. At the base of the article are documents of the Central Archive of the Ministry of Defense of the Russian Federation, recorded memories participants in the events of that time, published sources.

  18. Measurement of injected Sr in the stem of a Japanese cedar (Cryptomeria japonica D. Don) using PIXE

    International Nuclear Information System (INIS)

    Katayama, Y.; Aoki, T.; Ko, S.; Yoshida, K.

    1999-01-01

    Distribution profiles of Sr injected into the stem of a Japanese cedar (Cryptomeria japonica D. Don) were determined using PIXE. The Sr injected into the middle of the sapwood of the cedar stem moved upwards easily along the grain. The Sr in the stem moved in a radial direction in the sapwood section (assumed to be through the ray) and there was almost no tangential movement. (author)

  19. Projects for the Construction of Railways Between the Volga and the Don in 1930-1950s

    Directory of Open Access Journals (Sweden)

    Andrey V. Lunochkin

    2017-06-01

    Full Text Available The article is devoted to the connection of the Volga and Don rivers with railways in the place of greatest convergence (Perevoloka in the 1830-1850s. During this period Perevoloka has become a transport corridor of national significance, through which the main stream of the industrial and forest products was transferred from Central Russia and the Urals to the South of the country – the sea of Azov and the North Caucasus. The article discusses the project of A. Bestuzhev 1834, who bore the form of the most General propositions about the need to build such road. Due to the lack of specifics, the project was not approved by the officials of the Main Department of Railways and public buildings. The next project was a note by an unknown author, dating from about 1837. It contained detailed calculations of the amounts needed for the construction of two ways – on a railway-horse road and steam-powered road, as well as justification of the railway route between Dubovka suburb on the Volga river and the Kachalinskaya-on-Don village. This railway-horse road was built by the same name joint stock company in 1846, however, could not compete with horse-drawn transport. After the Crimean war, the proposal on connecting the Volga and Don railway was made by Baron A. Meyendorff, captain of Kassel company, engineer Joffry, mechanical engineer Davison, the Italian Consul in Taganrog de Rossi, but their proposals did not satisfy the government. Permission to conduct the survey was received in 1856 by Alexander Derevitsky and count N.I. Musin-Pushkin, but soon lost the rights to the project of company of N. Novosel, V. A. Kokorev and P.P. Melnikov. This joint stock company built the first Volga-Don railway in the South of Russia.

  20. Otras noticias -y las últimas- sobre la prosaica vida de Don Francisco Alvarez de Velasco y Zorrilla

    Directory of Open Access Journals (Sweden)

    Ernesto Porras Collantes

    2000-10-01

    Full Text Available Nos hemos topado con otras notidas sobre la vida y la familia de don FAVZ,2 que deseamos agregar a las ya aportadas en el estudio que sobre el poeta neogranadino hemos publicado. Las referentes a su vida tienen que ver con su empeño en adquirir la encomienda de Serinza y con su desempeño en la de Sogamoso, asuntos que le ocuparon en el período comprendido entre 1671 y 1677.

  1. Chivalry, Materialism, and the Grotesque in Don Quijote and Alberto Blest Gana’s El ideal de un calavera

    Directory of Open Access Journals (Sweden)

    Vilches Patricia

    2017-01-01

    Full Text Available This study analyses chivalry, materialism, and the grotesque in Alberto Blest Gana’s El ideal de un calavera [The Ideal of a Rogue] (1863 under the light of Miguel de Cervantes’s Don Quijote’s part II (1615. It underscores the legacy of Cervantes on the Chilean author especially in his reflections on nation building. Unlike its author, Don Quijote eluded restriction and successfully reached the colonies; once there, author and text became a massive influence on intellectuals in the burgeoning Americas. Blest Gana, for example, created protagonists who were multi-dimensional and imbued with quixotic overtones. Praised by his counterparts, he created work that was finely detailed, with a goal of portraying the nation’s cultural practices at specifics points in history. Deploying techniques inspired by Honore de Balzac (also a reader of Don Quijote, Blest Gana illustrated the colourful aspects of his society. His sharp eye depicted and interpreted nationhood and society through the course of dramatic historical events in El ideal de un calavera by shining a bright light on the political and social enemies who emerged in the historical unravelling of the nation in the 1830s. The resulting kaleidoscope of astute, idealistic and cowardly individuals conveyed subtle yet definite Cervantesque tones.

  2. Do endothelial cells dream of eclectic shape?

    Science.gov (United States)

    Bentley, Katie; Philippides, Andrew; Ravasz Regan, Erzsébet

    2014-04-28

    Endothelial cells (ECs) exhibit dramatic plasticity of form at the single- and collective-cell level during new vessel growth, adult vascular homeostasis, and pathology. Understanding how, when, and why individual ECs coordinate decisions to change shape, in relation to the myriad of dynamic environmental signals, is key to understanding normal and pathological blood vessel behavior. However, this is a complex spatial and temporal problem. In this review we show that the multidisciplinary field of Adaptive Systems offers a refreshing perspective, common biological language, and straightforward toolkit that cell biologists can use to untangle the complexity of dynamic, morphogenetic systems. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Hyperstructures, genome analysis and I-cells

    DEFF Research Database (Denmark)

    Amar, P.; Ballet, P.; Barlovatz-Meimon, G.

    2002-01-01

    familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial......New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types...

  4. Mitotic bookmarking in development and stem cells.

    Science.gov (United States)

    Festuccia, Nicola; Gonzalez, Inma; Owens, Nick; Navarro, Pablo

    2017-10-15

    The changes imposed on the nucleus, chromatin and its regulators during mitosis lead to the dismantlement of most gene regulatory processes. However, an increasing number of transcriptional regulators are being identified as capable of binding their genomic targets during mitosis. These so-called 'mitotic bookmarking factors' encompass transcription factors and chromatin modifiers that are believed to convey gene regulatory information from mother to daughter cells. In this Primer, we review mitotic bookmarking processes in development and stem cells and discuss the interest and potential importance of this concept with regard to epigenetic regulation and cell fate transitions involving cellular proliferation. © 2017. Published by The Company of Biologists Ltd.

  5. Quantitative stem cell biology: the threat and the glory.

    Science.gov (United States)

    Pollard, Steven M

    2016-11-15

    Major technological innovations over the past decade have transformed our ability to extract quantitative data from biological systems at an unprecedented scale and resolution. These quantitative methods and associated large datasets should lead to an exciting new phase of discovery across many areas of biology. However, there is a clear threat: will we drown in these rivers of data? On 18th July 2016, stem cell biologists gathered in Cambridge for the 5th annual Cambridge Stem Cell Symposium to discuss 'Quantitative stem cell biology: from molecules to models'. This Meeting Review provides a summary of the data presented by each speaker, with a focus on quantitative techniques and the new biological insights that are emerging. © 2016. Published by The Company of Biologists Ltd.

  6. Nonlinear dynamics, Waddington landscape and stem cells

    Science.gov (United States)

    Tang, Chao

    There are hundreds of different cell types (skin, neuron, muscle, etc.) in human body, all derived from the stem cell and all have the same genetic information. About 60 years ago, Waddington speculated that the different cell types correspond to different minima in a landscape emerged from genetic interactions. Recently, biologists succeeded in transforming one cell type to another by perturbing the genetic interactions in a cell. I will discuss the experiments and a mathematical model of a set of such cell type transformations in mice, in which we can see an actual example of the Waddington landscape and ways to alter it to facilitate cell type transformation - in particular, to reprogram a differentiated cell back into a stem cell.

  7. Shattering Man’s Fundamental Assumptions in Don DeLillo’s Falling Man

    Directory of Open Access Journals (Sweden)

    Hazim Adnan Hashim

    2016-09-01

    Full Text Available The present study addresses effects of traumatic events such as the September 11 attacks on victims’ fundamental assumptions. These beliefs or assumptions provide individuals with expectations about the world and their sense of self-worth. Thus, they ground people’s sense of security, stability, and orientation. The September 11 terrorist attacks in the U.S.A. were very tragic for Americans because this fundamentally changed their understandings about many aspects in life. The attacks led many individuals to build new kind of beliefs and assumptions about themselves and the world. Many writers have written about the human ordeals that followed this incident. Don DeLillo’s Falling Man reflects the traumatic repercussions of this disaster on Americans’ fundamental assumptions. The objective of this study is to examine the novel from the traumatic perspective that has afflicted the victims’ fundamental understandings of the world and the self. Individuals’ fundamental understandings could be changed or modified due to exposure to certain types of events like war, terrorism, political violence or even the sense of alienation. The Assumptive World theory of Ronnie Janoff-Bulman will be used as a framework to study the traumatic experience of the characters in Falling Man. The significance of the study lies in providing a new perception to the field of trauma that can help trauma victims to adopt alternative assumptions or reshape their previous ones to heal from traumatic effects.

  8. The Presence of Don Quijote in the Beginnings of the Special Education in Galicia

    Directory of Open Access Journals (Sweden)

    Ana Rodríguez Díaz

    2015-12-01

    Full Text Available This article aims to show the presence of the work of Cervantes, “Don Quijote de la Mancha”, in the unique establishments existing in Galicia at the beginning of the 20th century, dedicated to special education. According to this claim, reference is made to two significant anniversaries in the dissemination of the work. The first one corresponds to the commemoration of the third centenary of the birth of the Cuisse. In this Establishment one would organize in the year 1905, in the free School of blind persons and poor children of To Corunna. A very complete festival as appears in the content of the program, which has recovered of the historical municipal file of the above mentioned city. The second event, refers to the presentation of the novel by Cervantes, written in Braille. Quite a challenge for teachers in special schools of the time, as the College of deaf and blind from Santiago de Compostela, the first school for the teaching of these students, which is established in Spain for the purposes of the law of public instruction of 1857, will assume early.

  9. "Don't know" answers concerning somatic disease status should not be regarded as "no" responses

    Directory of Open Access Journals (Sweden)

    Baumeister, Harald

    2008-06-01

    Full Text Available Background: With regard to patients' self-reported somatic diseases some researchers transformed “don't know (DK” responses into “no” responses. The present study examines the appropriateness of this procedure. Methods: Analyses were based on the nationally representative German National Health Interview and Examination Survey (GHS, which assessed both self-reported diseases and physician-diagnosed diseases (N = 7124. Prevalence rates of persons’ DK responses and the corresponding prevalences of physicians’ diagnoses were calculated for persons with hypertension, coronary heart disease (CHD, heart failure, asthma, chronic bronchitis, thyroid disease, diabetes, cancer, gout, arthrosis, arthritis and osteoporosis. Correlates of physicians' diagnosed diseases of DK cases are reported. Results: Between 1.6% and 9.8% of the participants responded with DK to the question of whether they have the disease. In 3.7% to 29.5% of DK cases, the physicians did regard the respective disease as being present. With regard to persons who responded with DK, the probability of a physicians' diagnosis was increased in the case of increased age and a higher number of somatic comorbidities. Conclusion: The procedure of transforming DK responses into “no” answers does not appear to be recommendable.

  10. On Building Materials and Metrology of Khazar-Alan Fortified Sites in the Don River Basin

    Directory of Open Access Journals (Sweden)

    Afanasiev Gennady Ye.

    2012-06-01

    Full Text Available The question related to the origins of the of the Saltovo-Mayaki culture architectural traditions embodied in the Khazar-Alan fortresses of the Don basin is raised in the article. According to the author, the emergence of brick architecture in Khazaria is connected with the activity of the masters from Byzantine Cherson (Chersonese and Asian Bosporus. The study of the parameters of the bricks from the wall ruins of the Mayaki fortified settlement site makes it possible to conclude that the fortress had been built by specialists who were well acquainted with Byzantine metrology and Byzantine architectural traditions. Metrological and chronological characteristics of Khazar-Alan fortified settlement sites gives grounds to associate their construction with the information from Byzantine sources on the construction of Sarkel fortress by Byzantine specialists. It corresponded to the interests of both Byzantium and Khazaria in connection with the general political situation between the Khazar Khaganate, the Byzantine Empire, Alania, Old Rus and the Arab Caliphate in 30-50s of the 9th century.

  11. Performance of a new 3D-only PET scanner - the EXACT3D

    Energy Technology Data Exchange (ETDEWEB)

    Spinks, T.J.; Bailey, D.L.; Miller, M. [Hammersmith Hospital, London (United Kingdom)] [and others

    1996-12-31

    Characteristics of currently the highest sensitivity 3D-only PET scanner (CTI/Siemens 966/EXACT3D) have been studied. The device has 48 rings (82cm diameter) of BGO detector elements (4.0 x 4.1 x 30mm, 8 x 8 block) and an axial FOV of 23.4cm. Attenuation correction is carried out with a point source of {sup 137}Cs which moves under hydraulic pressure in a helical tube. Transaxial resolution is 4.7mm 1cm from the centre of the FOV increasing, in the radial direction to 6.3mm and 7.3mm at 10cm and 15cm. At a lower threshold of 350keV, the scatter fraction is 40%. With scatter subtracted, the efficiency (20cm cylinder) is 6.9 x 104 cps/kBq/ml (maximum ring difference of 40); the absolute sensitivity is 5.8%. In the current configuration, the maximum total coincidence event rate is limited to about 3 x 10{sup 6} per sec. The maximum trues rate is about 850kcps (90MBq in the FOV). List mode acquisition has been implemented to maximize temporal resolution and optimize data storage. The more open geometry of this device gives a broader singles FOV. Hence administered doses and/or additional side-shielding need to be carefully considered to optimize noise-equivalent counts.

  12. Analysis of the Gaia RVS Region in ESPaDOnS Spectra of Asteroseismic Calibration Stars

    Science.gov (United States)

    Vesa, Oana; Huber, Daniel; Gaidos, Eric

    2018-01-01

    While surface gravity can be measured from asteroseismology, asteroseismology cannot be applied to every star. Surface gravity is a critical stellar parameter because it can be used to calculate the radii of stars, which is important in the characterization of host stars of exoplanets. Here we present spectroscopic observations from ESPaDOnS on the Canada-France-Hawaii Telescope of 172 benchmark “gold standard” stars observed by the NASA Kepler Mission for which densities and surface gravities have been precisely measured using asteroseismology. The goal is to discover an empirical correlation between the equivalent width of the spectral lines in the infrared Ca II triplet region (from 8470 to 8710 angstroms) against surface gravity and other stellar parameters, such as effective temperature and metallicity. The Mg I line at 8736 angstroms has the best potential to be an indicator of surface gravity so far out of the spectral lines in this region with equivalent width increasing slightly as a function of surface gravity; however, degeneracies with effective temperature and metallicity need to be explored further. If a true indicator for surface gravity can be found, then it can to be applied to the R~11000 Gaia radial velocity spectra, which will be released for millions of stars over the coming years.

  13. Proteomic profiling of proteins associated with the rejuvenation of Sequoia sempervirens (D. Don Endl

    Directory of Open Access Journals (Sweden)

    Chen Yu-Ting

    2010-12-01

    Full Text Available Abstract Background Restoration of rooting competence is important for rejuvenation in Sequoia sempervirens (D. Don Endl and is achieved by repeatedly grafting Sequoia shoots after 16 and 30 years of cultivation in vitro. Results Mass spectrometry-based proteomic analysis revealed three proteins that differentially accumulated in different rejuvenation stages, including oxygen-evolving enhancer protein 2 (OEE2, glycine-rich RNA-binding protein (RNP, and a thaumatin-like protein. OEE2 was found to be phosphorylated and a phosphopeptide (YEDNFDGNSNVSVMVpTPpTDK was identified. Specifically, the protein levels of OEE2 increased as a result of grafting and displayed a higher abundance in plants during the juvenile and rejuvenated stages. Additionally, SsOEE2 displayed the highest expression levels in Sequoia shoots during the juvenile stage and less expression during the adult stage. The expression levels also steadily increased during grafting. Conclusion Our results indicate a positive correlation between the gene and protein expression patterns of SsOEE2 and the rejuvenation process, suggesting that this gene is involved in the rejuvenation of Sequoia sempervirens.

  14. Don Draper Thinks Your Ad Is Cliché: Fairy Tale Iconography in TV Commercials

    Directory of Open Access Journals (Sweden)

    Preston Wittwer

    2016-05-01

    Full Text Available When examining the history of fairy tale iconography in advertising, folklore scholar Donald Haase’s fairy tale encyclopedia compared the Pied Piper of Hamelin to a symbol of advertising who could “play his pipe ever so sweetly and the consumers following him without resisting his charming and manipulative music.” In contrast, a 2012 episode of Mad Men, advertising luminary Don Draper shoots down a shoe commercial pitch featuring Cinderella, calling the idea “cliché”. The temptation for advertisers to rely on fairy tale figures and iconography continues today and many ignore Don’s aversion for cliché because it still gets the job done. However, there are some ads featuring fairy tales which avoid cliché and are truly innovative for their time. I’ll examine how, and for whom, these fairy tale figures have been adapted decade by decade in order to examine popular culture’s commercialized and hypnotic relationship with fairy tales in the most direct format available: television commercials.

  15. Performance of a new 3D-only PET scanner - the EXACT3D

    International Nuclear Information System (INIS)

    Spinks, T.J.; Bailey, D.L.; Miller, M.

    1996-01-01

    Characteristics of currently the highest sensitivity 3D-only PET scanner (CTI/Siemens 966/EXACT3D) have been studied. The device has 48 rings (82cm diameter) of BGO detector elements (4.0 x 4.1 x 30mm, 8 x 8 block) and an axial FOV of 23.4cm. Attenuation correction is carried out with a point source of 137 Cs which moves under hydraulic pressure in a helical tube. Transaxial resolution is 4.7mm 1cm from the centre of the FOV increasing, in the radial direction to 6.3mm and 7.3mm at 10cm and 15cm. At a lower threshold of 350keV, the scatter fraction is 40%. With scatter subtracted, the efficiency (20cm cylinder) is 6.9 x 104 cps/kBq/ml (maximum ring difference of 40); the absolute sensitivity is 5.8%. In the current configuration, the maximum total coincidence event rate is limited to about 3 x 10 6 per sec. The maximum trues rate is about 850kcps (90MBq in the FOV). List mode acquisition has been implemented to maximize temporal resolution and optimize data storage. The more open geometry of this device gives a broader singles FOV. Hence administered doses and/or additional side-shielding need to be carefully considered to optimize noise-equivalent counts

  16. At the End is Piuraa: The Raven's Gift by Don Rearden

    Directory of Open Access Journals (Sweden)

    Marija Krivokapić

    2017-12-01

    Full Text Available This paper considers Alaskan author Don Rearden’s novel The Raven’s Gift (2011. The novel deals with environmental injustice, and is built around an apocalyptic plot, depicting the destruction of the Alaskan Yup’ik community through several forms of genocide, culminating with an artificially induced virus. However, the novel ends with a substantial degree of hope imminent in the concept of piuraa, which is pregnant with the spirit of the place and the nature of the Native culture. This concept is conceived in the imagination of a holistic circular cosmogony of the Native culture, and is contrasted to the linear spirit and nature of the progressive civilization which eventually must imagine ends of societies and cultures. Therefore, the paper discusses Rearden’s novel against the background of some recent historical, ecocritical, and sociological studies, such as those of Francis Fukuyama, Jared Diamond, and Peter Turchin, as well as through the lens of indigenous epistemology as interpreted by Daniel Heath Justice and John Trudell.

  17. Don Cossack Army Charters of the Mid 18th Century Via the Category of Modality

    Directory of Open Access Journals (Sweden)

    Elena Mihaylovna Sheptukhina

    2015-12-01

    Full Text Available The article deals with the language means of modality in the texts of military charters of the mid 18th cent. from the "Mikhailovsky stanitza hetman" archive (State Achieve of Volgograd Region. Military charters used to be major documents of legislation within Don Cossack Host, as being at that time an administrative unit in the territory of Russian Empire. The results of the contextual analysis verify the following facts: the charter texts are mainly characterized by an imperative tone of regulation that is caused by coordination between dominant meanings of a propositional (situational modality of necessity and pragmatic modality of volition, that are thought to be interrelated in utterances. The modal meaning of necessity is marked by the verbal construction with an independent infinitive or the combinations of modal verbs (imet' / possess; nadlezhat' / be to, modal predicatives with a dependent infinitive (dolzhen, nadobno, etc. / must (have to. Modality of volition is presented with a set of lexical units that possess the meanings of ordering, permission, offers, verbal forms that are used as performatives, or point to the status of a subject, etc. The texts under study represent some other modal meanings: possibility (with the words moch' / be able to; mozhno / could / may combined with an infinitive, in subordinate clauses with a particle li (if / wether, etc. in an interrogative clauses. In complex sentences with subordination combinations of various modal meanings are observed.

  18. Synthesis of silver nanoparticles using leaves of Catharanthus roseus Linn. G. Don and their antiplasmodial activities

    Science.gov (United States)

    Ponarulselvam, S; Panneerselvam, C; Murugan, K; Aarthi, N; Kalimuthu, K; Thangamani, S

    2012-01-01

    Objective To develop a novel approach for the green synthesis of silver nanoparticles using aqueous leaves extracts of Catharanthus roseus (C. roseus) Linn. G. Don which has been proven active against malaria parasite Plasmodium falciparum (P. falciparum). Methods Characterizations were determined by using ultraviolet-visible (UV-Vis) spectrophotometry, scanning electron microscopy (SEM), energy dispersive X-ray and X-ray diffraction. Results SEM showed the formation of silver nanoparticles with an average size of 35–55 nm. X-ray diffraction analysis showed that the particles were crystalline in nature with face centred cubic structure of the bulk silver with the broad peaks at 32.4, 46.4 and 28.0. Conclusions It can be concluded that the leaves of C. roseus can be good source for synthesis of silver nanoparticle which shows antiplasmodial activity against P. falciparum. The important outcome of the study will be the development of value added products from medicinal plants C. roseus for biomedical and nanotechnology based industries. PMID:23569974

  19. The Nazarov Complex of the Lower Don: on Zoroastrianism of the Khazar Ethnos

    Directory of Open Access Journals (Sweden)

    Leonid S. Ilyukov

    2017-10-01

    Full Text Available Among the early medieval antiquities of the Lower Don basin, two funerary complexes are of interest. One was accidentally discovered in 1914 in the Cossack village Nazarov, and the other – near the settlement Bolshaya Orlovka in 1972. Based upon the Byzantine solidities, found in their inventory, they date from the first half of the 8th century. Two iron lamps in the form of bowls on a high leg were found in these funerary complexes along with a diverse and prestigious inventory. In addition to them, two iron composite altars of different sizes were found in the Bolshaya Orlovka. In the early medieval burial mound near the Brusyana village in the Volga region a solidcast iron lamp-altar was found, consisting of a bowl in the form of a concave disc on a long leg, which was welded in the center of a hexagonal bowl with low straight sides and a flat bottom. Short legs are located at its three corners. Typologically Brusian discovery was later then those of the Nazarov and the Bolshaya Orlovka. It unites the altar, consisting of threebowls with low straight bows and a flat bottom, with a lamp. Short legs are located at its three corners of the bowls. These were specific bowls that were used to carry fire during rituals of steppe nomads who had close cultural contacts with the fire worshipers of Sasanid Iran, whose population professed Zoroastrianism.

  20. 'I don't want to hate him forever': understanding daughter's experiences of father absence.

    Science.gov (United States)

    East, Leah; Jackson, Debra; O'Brien, Louise

    2007-01-01

    Father absence is associated with negative child and adolescent outcomes, including early sexual activity, teenage pregnancy, behavioural difficulties and life adversity. However there is a lack of literature that explores the lived experiences of daughters who grew up in father absent environments. This study aimed to generate insights into the lived experience of being a girl-child growing up in a father absent environment through the perspectives of daughters who experienced father absence during their childhood and/or adolescent years. Van Manen's phenomenological research approach informed this study. Participants were recruited through the news media and took part in phenomenological interviews. Narrative was transcribed and analysed using Van Manen's thematic approach. Nine women aged between 22-46 years who had been raised by their biological mothers and who had experienced father absence due to parental relationship breakdown participated in the study. Four themes that captured the participants lived experiences of father absence were revealed. These are: He always let me down: a constant source of hurt; I have no feelings of closeness: father as a stranger; All men are bastards: negotiating relationships with men; and, I don't want to hate him forever: reconstructing the relationship. Nurses and other health workers are challenged to meet the needs of increasing numbers of father absent children and young people and to develop supportive strategies to ameliorate the effects of father absence so as to contribute to the best possible outcomes for young people and their families.

  1. What consumers don't know about genetically modified food, and how that affects beliefs.

    Science.gov (United States)

    McFadden, Brandon R; Lusk, Jayson L

    2016-09-01

    In the debates surrounding biotechnology and genetically modified (GM) food, data from consumer polls are often presented as evidence for precaution and labeling. But how much do consumers actually know about the issue? New data collected from a nationwide U.S. survey reveal low levels of knowledge and numerous misperceptions about GM food. Nearly equal numbers of consumers prefer mandatory labeling of foods containing DNA as do those preferring mandatory labeling of GM foods. When given the option, the majority of consumers prefer that decisions about GM food be taken out of their hands and be made by experts. After answering a list of questions testing objective knowledge of GM food, subjective, self-reported knowledge declines somewhat, and beliefs about GM food safety increase slightly. Results suggest that consumers think they know more than they actually do about GM food, and queries about GM facts cause respondents to reassess how much they know. The findings question the usefulness of results from opinion polls as a motivation for creating public policy surrounding GM food.-McFadden, B. R., Lusk, J. L. What consumers don't know about genetically modified food, and how that affects beliefs. © FASEB.

  2. 60 years of CERN at UNESCO | Don't miss the webcast! | 1 July

    CERN Multimedia

    2014-01-01

    Don't miss the live webcast of the commemoration ceremony, marking the signature of the CERN Convention. The ceremony will be held at the UNESCO Headquarters in Paris on 1 July, from 10 a.m.   To watch the webcast, please visit: http://webcast.web.cern.ch/webcast/ from 10 a.m. Programme 10 a.m. - 11 a.m.: Opening of Ceremony by Maciej Nalecz, Director of the Division of Science Policy and Capacity Building, UNESCO   Address by Irina Bokova, Director-General of UNESCO   Address by Rolf Heuer, Director-General of CERN   Video clip “CERN: 60 years of science for peace”   Address by Agnieszka Zalewska, President of the CERN Council   Hommage à François de Rose, un des pères fondateurs du CERN, par sa fille Laurence Rousselot   CERN as seen by a young phycisist, Claire Lee (ATLAS Collaboration) 11 a.m. - 12 p.m.: Roundtable discussion on “Science for...

  3. Nuclear power plant transient diagnostics using artificial neural networks that allow ''don't-know'' classifications

    International Nuclear Information System (INIS)

    Bartal, Y.; Lin, J.; Uhrig, R.E.

    1995-01-01

    A nuclear power plant's (NPP's) status is usually monitored by a human operator. Any classifier system used to enhance the operator's capability to diagnose a safety-critical system like an NPP should classify a novel transient as ''don't-know'' if it is not contained within its accumulated knowledge base. In particular, the classifier needs some kind of proximity measure between the new data and its training set. Artificial neural networks have been proposed as NPP classifiers, the most popular ones being the multilayered perceptron (MLP) type. However, MLPs do not have a proximity measure, while learning vector quantization, probabilistic neural networks (PNNs), and some others do. This proximity measure may also serve as an explanation to the classifier's decision in the way that case-based-reasoning expert systems do. The capability of a PNN network as a classifier is demonstrated using simulator data for the three-loop 436-MW(electric) Westinghouse San Onofre unit 1 pressurized water reactor. A transient's classification history is used in an ''evidence accumulation'' technique to enhance a classifier's accuracy as well as its consistency

  4. El infante don Gabriel y el impresor Ibarra en la obra cumbre del Salustio

    Directory of Open Access Journals (Sweden)

    Olaechea Labayen, Juan B.

    1997-04-01

    Full Text Available Not available.En la obra conocida como el «Salustio de Ibarra», considerada por especialistas domésticos y foráneos como la mejor impresa en España, convergen circunstancias relevantes debidas a la participación intelectual del infante don Gabriel de Borbón y la eficiencia técnica de Joaquín Ibarra. El autor reivindica la autenticidad de los textos atribuidos al infante contra cierto escepticismo sembrado en razón de la elevada alcurnia de la atribución. Seguidamente, se realiza el análisis de las cualidades técnicas de la impresión, eminentes en una época de esplendor del arte impresorio, y en cuya confección colaboraron los más descollantes artistas del buril de aquel período considerado de triunfo de la estampa ilustrada.

  5. Cadmium accumulation characteristics of the winter farmland weeds Cardamine hirsuta Linn. and Gnaphalium affine D. Don.

    Science.gov (United States)

    Lin, Lijin; Shi, Jun; Liu, Qihua; Liao, Ming'an; Mei, Luoyin

    2014-07-01

    In a preliminary study, we found that the cadmium (Cd) concentrations in shoots of the winter farmland weeds Cardamine hirsuta Linn. and Gnaphalium affine D. Don exceeded the critical value of a Cd-hyperaccumulator (100 mg kg(-1)), indicating that these two farmland weeds might be Cd-hyperaccumulators. In this study, we grew these species in soil containing various concentrations of Cd to further evaluate their Cd accumulation characteristics. The biomasses of C. hirsuta and G. affine decreased with increasing Cd concentrations in the soil, while the root/shoot ratio and the Cd concentrations in shoot tissues increased. The Cd concentrations in shoots of C. hirsuta and G. affine reached 121.96 and 143.91 mg kg(-1), respectively, at the soil Cd concentration of 50 mg kg(-1). Both of these concentrations exceeded the critical value of a Cd-hyperaccumulator (100 mg kg(-1)). The shoot bioconcentration factors of C. hirsuta and G. affine were greater than 1. The translocation factor of C. hirsuta was less than 1 and that of G. affine was greater than 1. These findings indicated that C. hirsuta is a Cd-accumulator and G. affine is Cd-hyperaccumulator. Both plants are distributed widely in the field, and they could be used to remediate Cd-contaminated farmland soil in winter.

  6. El Don Juan Tenorio de Zorrila: entre el carnival y la cuaresma*

    Directory of Open Access Journals (Sweden)

    Ana Alcolea

    1999-12-01

    Full Text Available Mucha tinta ha cobrado forma de escritura en torno a la figura de Don Juan. Y esto, no sólo en estudios bibliográficos y aparato critico, sino y sobre todo, en la casi infinidad de versiones liricas, novelísticas, y dramáticas que a lo largo de los cuatro últimos siglos han tenido como protagonista al "notorio" sevillano o a cualquiera de sus hijos literarios. La obra del vallisoletano José Zorrilla ha sido, sin duda, la que en España se ha convertido en la referencia más tradicional del asunto donjuanesco. En estas páginas vamos a intentar acercarnos a ella a tráves de sus lazos con los mundos del carnaval y Ia cuaresma que, a mi modo de ver, generan y articulan las dos partes que estructuran externa e internamente el drama. Para ello, primero pasearemos brevemente por los orígenes miticos del donjuanismo, que nos llevarán a entornos escatológicos que fusionan mitos y leyendas de diversos linajes: bíblico, griego, hindú, germánico...

  7. Mutagenicity and antimutagenicity of Salacia crassifolia (mart. Ex. Schult. G. Don. evaluated by Ames test

    Directory of Open Access Journals (Sweden)

    C. C. Carneiro

    2017-09-01

    Full Text Available Abstract Salacia crassifolia (Mart. Ex. Schult. G. Don. is a bush which belongs to Celastraceae family and occurs specially in Brazilian Cerrado. Its leaves, stem, seeds and fruits are popularly used for several medicinal purposes, such as antitumoral, antirheumatic, anti-inflammatory and antimicrobial. In this study, the mutagenic and antimutagenic activities of S. crassifolia stem bark fractions (hexane, ethyl acetate and hydroalcoholic were evaluated by the Ames mutagenicity assay in Salmonella typhimurium TA98 and TA100 strains. By the obtained results, all S. crassifolia fractions did not significantly increase the number of prototrophic revertants for histidine (His+ in both S. typhimurium strains tested (p > 0.05, suggesting absence of mutagenicity. Regarding antimutagenicity, the fractions ethyl acetate and hydroalcoholic significantly decreased the number of His+ revertants colonies induced by positive control for strain TA98 (p < 0.05, demonstrating protection against mutagenicity induced by 4-nitroquinolile1-oxide, whereas the hexane fraction did not show antimutagenic effect in this strain. In the TA100 strain, all fractions of S. crassifolia protected DNA against the harmful action of sodium azide, and the hexane fraction exhibited the greatest protection in this work. Thus, it’s possible conclude that the fractions of S. crassifolia tested in this study could be used in chemoprevention.

  8. Analysis of Multiple Partially Ordered Responses to Belief Items with Don't Know Option.

    Science.gov (United States)

    Ip, Edward H; Chen, Shyh-Huei; Quandt, Sara A

    2016-06-01

    Understanding beliefs, values, and preferences of patients is a tenet of contemporary health sciences. This application was motivated by the analysis of multiple partially ordered set (poset) responses from an inventory on layman beliefs about diabetes. The partially ordered set arises because of two features in the data-first, the response options contain a Don't Know (DK) option, and second, there were two consecutive occasions of measurement. As predicted by the common sense model of illness, beliefs about diabetes were not necessarily stable across the two measurement occasions. Instead of analyzing the two occasions separately, we studied the joint responses across the occasions as a poset response. Few analytic methods exist for data structures other than ordered or nominal categories. Poset responses are routinely collapsed and then analyzed as either rank ordered or nominal data, leading to the loss of nuanced information that might be present within poset categories. In this paper we developed a general class of item response models for analyzing the poset data collected from the Common Sense Model of Diabetes Inventory. The inferential object of interest is the latent trait that indicates congruence of belief with the biomedical model. To apply an item response model to the poset diabetes inventory, we proved that a simple coding algorithm circumvents the requirement of writing new codes such that standard IRT software could be directly used for the purpose of item estimation and individual scoring. Simulation experiments were used to examine parameter recovery for the proposed poset model.

  9. Removal characteristics of DON in pharmaceutical wastewater and its influence on the N-nitrosodimethylamine formation potential and acute toxicity of DOM.

    Science.gov (United States)

    Hu, Haidong; Jiang, Cong; Ma, Haijun; Ding, Lili; Geng, Jinju; Xu, Ke; Huang, Hui; Ren, Hongqiang

    2017-02-01

    Previous research has focused on dissolved organic carbon (DOC) as a surrogate for dissolved organic matter (DOM) in pharmaceutical wastewater. Dissolved organic nitrogen (DON) as a part of DOM has received little attention. This study investigated the removal characteristics of DON and its influence on the N-nitrosodimethylamine formation potential (NDMA FP) and acute toxicity of DOM in a full-scale hydrolysis/acidification + anaerobic/anoxic/aerobic + moving bed biofilm reactor (MBBR) process treating pharmaceutical wastewater. Results showed that maximum removal of DON (68 ± 12%) was present in the anaerobic process. The removal of DON by anoxic and aerobic processes was negligible as a result of the production of new N-containing compounds that are characteristic of proteins/amino sugars and lipids. DON concentration decreased significantly in the MBBR process (p toxicity was significantly associated with the 3 kDa wastewater was recommended, as it provides important information for DOM removal characteristics. Copyright © 2016. Published by Elsevier Ltd.

  10. Run don't walk: locomotor performance of geckos on wet substrates.

    Science.gov (United States)

    Stark, Alyssa Y; Ohlemacher, Jocelyn; Knight, Ashley; Niewiarowski, Peter H

    2015-08-01

    The gecko adhesive system has been under particular scrutiny for over a decade, as the field has recently attracted attention for its application to bio-inspired design. However, little is known about how the adhesive system behaves in ecologically relevant conditions. Geckos inhabit a variety of environments, many of which are characterized by high temperature, humidity and rain. The van der Waals-based gecko adhesive system should be particularly challenged by wet substrates because water can disrupt the intimate contact necessary for adhesion. While a few previous studies have focused on the clinging ability of geckos on wet substrates, we tested a dynamic performance characteristic, sprint velocity. To better understand how substrate wettability and running orientation affect locomotor performance of multiple species on wet substrates, we measured average sprint velocity of five species of gecko on substrates that were either hydrophilic or intermediately wetting and oriented either vertically or horizontally. Surprisingly, we found no indication that wet substrates impact average sprint velocity over 1 m, and rather, in some species, sprint velocity was increased on wet substrates rather than reduced. When investigating physical characteristics and behavior that may be associated with running on wet substrates, such as total number of stops, slips and wet toes at the completion of a race, we found that there may be habitat-related differences between some species. Our results show that in general, unlike clinging and walking, geckos running along wet substrates suffer no significant loss in locomotor performance over short distances. © 2015. Published by The Company of Biologists Ltd.

  11. Survey of genome sequences in a wild sweet potato, Ipomoea trifida (H. B. K.) G. Don

    Science.gov (United States)

    Hirakawa, Hideki; Okada, Yoshihiro; Tabuchi, Hiroaki; Shirasawa, Kenta; Watanabe, Akiko; Tsuruoka, Hisano; Minami, Chiharu; Nakayama, Shinobu; Sasamoto, Shigemi; Kohara, Mitsuyo; Kishida, Yoshie; Fujishiro, Tsunakazu; Kato, Midori; Nanri, Keiko; Komaki, Akiko; Yoshinaga, Masaru; Takahata, Yasuhiro; Tanaka, Masaru; Tabata, Satoshi; Isobe, Sachiko N.

    2015-01-01

    Ipomoea trifida (H. B. K.) G. Don. is the most likely diploid ancestor of the hexaploid sweet potato, I. batatas (L.) Lam. To assist in analysis of the sweet potato genome, de novo whole-genome sequencing was performed with two lines of I. trifida, namely the selfed line Mx23Hm and the highly heterozygous line 0431-1, using the Illumina HiSeq platform. We classified the sequences thus obtained as either ‘core candidates’ (common to the two lines) or ‘line specific’. The total lengths of the assembled sequences of Mx23Hm (ITR_r1.0) was 513 Mb, while that of 0431-1 (ITRk_r1.0) was 712 Mb. Of the assembled sequences, 240 Mb (Mx23Hm) and 353 Mb (0431-1) were classified into core candidate sequences. A total of 62,407 (62.4 Mb) and 109,449 (87.2 Mb) putative genes were identified, respectively, in the genomes of Mx23Hm and 0431-1, of which 11,823 were derived from core sequences of Mx23Hm, while 28,831 were from the core candidate sequence of 0431-1. There were a total of 1,464,173 single-nucleotide polymorphisms and 16,682 copy number variations (CNVs) in the two assembled genomic sequences (under the condition of log2 ratio of >1 and CNV size >1,000 bases). The results presented here are expected to contribute to the progress of genomic and genetic studies of I. trifida, as well as studies of the sweet potato and the genus Ipomoea in general. PMID:25805887

  12. La sombra del arcediano. El linaje oculto de don Lorenzo Galíndez de Carvajal

    Directory of Open Access Journals (Sweden)

    Baltasar CUART MONER

    2009-11-01

    Full Text Available RESUMEN: D. Lorenzo Galíndez de Carvajal fue un personaje destacado en la Corte de los Reyes Católicos y Carlos V, además de cronista real. Sin embargo, para alcanzar esta posición tuvo que manipular sus orígenes familiares, siendo como era hijo de un arcediano de Coria y de una moza de servicio en una posada. Las manipulaciones de don Lorenzo tuvieron el éxito apetecido, sin embargo, treinta años después de su muerte, las informaciones realizadas sobre un nieto suyo que quería ingresar en el Colegio Mayor de Oviedo, en Salamanca, sacaron a la luz toda la estrategia familiar que tuvo que poner en marcha su ilustre abuelo para alcanzar la posición a la que llegó.ABSTRACT: D. Lorenzo Galíndez de Carvajal was one of the most influential courtiers at the Catholic King's court. He, too, was one of their chroniclers, but he had to forge his familiar origins in order to hold his job. He was an illegitimate son; his father was an archdeacon in Coria and his mother a maidservant. D. Lorenzo Galíndez de Carvajal succeeded in hiding his origins and his descendants became related to nobility by marriage. Howeyer all his grandfather's impostures and the ways followed by aristocracy to manipulate its origins were discovered when one of his grandsons tried to be admitted to the Oviedo College about the middle of the XVIth century.

  13. Selection of Reliable Reference Genes for Gene Expression Studies on Rhododendron molle G. Don

    Directory of Open Access Journals (Sweden)

    Zheng Xiao

    2016-10-01

    Full Text Available The quantitative real-time polymerase chain reaction (qRT-PCR approach has become a widely used method to analyze expression patterns of target genes. The selection of an optimal reference gene is a prerequisite for the accurate normalization of gene expression in qRT-PCR. The present study constitutes the first systematic evaluation of potential reference genes in Rhododendron molle G. Don. Eleven candidate reference genes in different tissues and flowers at different developmental stages of R. molle were assessed using the following three software packages: GeNorm, NormFinder and BestKeeper. The results showed that EF1-α (elongation factor 1-alpha, 18S (18s ribosomal RNA and RPL3 (ribosomal protein L3 were the most stable reference genes in developing rhododendron flowers and, thus, in all of the tested samples, while tublin (TUB was the least stable. ACT5 (actin, RPL3, 18S and EF1-α were found to be the top four choices for different tissues, whereas TUB was not found to favor qRT-PCR normalization in these tissues. Three stable reference genes are recommended for the normalization of qRT-PCR data in R. molle. Furthermore, the expression profiles of RmPSY (phytoene synthase and RmPDS (phytoene dehydrogenase were assessed using EF1-α, 18S, ACT5, and RPL3 and their combination as internals. Similar trends were found, but these trends varied when the least stable reference gene TUB was used. The results further prove that it is necessary to validate the stability of reference genes prior to their use for normalization under different experimental conditions. This study provides useful information for reliable qRT-PCR data normalization in gene studies of R. molle.

  14. Orthodox Clergy of the Lower Volga and the Don in 1940–1953

    Directory of Open Access Journals (Sweden)

    Redkina Olga

    2014-12-01

    Full Text Available The article presents the regional specificity of the formation of the Orthodox clergy in the Lower Volga and Don in the 1940–1950s. The Battle of Stalingrad was the starting point of the Orthodox revival in the region. During the Battle of Stalingrad the opening of Orthodox churches, the restoration of the church structure began. Opened churches paralleled in the occupied territories of the Rostov and Stalingrad regions and border areas of the Stalingrad region, the Saratov region and the Astrakhan region. During 1942–1944 the Rostov region had about 251 Orthodox churches; the Stalingrad region – 17, ithe Astrakhan region – 3, the Saratov region – 4. In 1953, the Rostov region had 219 churches, the Stalingrad region – 31; the Astrakhan region – 16, the Saratov region – 14. The largest diocese in the region was Diocese of Rostov and Novocherkassk. As of Autumn 1945, the clergy consisted of one bishop, 200 priests, 14 deacons, 76 acolytes. Most of them returned to the church service during the occupation. In the Stalingrad region the number of clergy who served in the occupied territories, was minimal. In Rostov and Stalingrad not all parishes have registered clergy. In Astrakhan and Saratov state churches were fully staffed, but lacked the acolytes. Solving the personnel problems in the Church, bishops of the region actively ordained priests of the deacons, acolytes, church asset; invited to the service the priests released from places of exile and imprisonment, were on the rest of the staff, who returned to the bosom of the Orthodox Church of Renovationist split. Most of the clergy belonged to the older generation and took holy orders until 1917. In the 1950s, the region's clergy was replenished by graduates of seminaries, the priests of the Western Belarus and Ukraine. Restrictive government policies prevented the restoration of church life. The lack of priests caused the reduction in the number of registered Orthodox parishes

  15. Climate as possible reproductive barrier in Pinus radiata (D. Don interspecific hybridisation

    Directory of Open Access Journals (Sweden)

    Hannél Ham

    2017-12-01

    Full Text Available Historically, interspecific hybridisation with Pinus radiata D. Don had limited success. The effect of environmental conditions and position of pollination bags in the tree were investigated as possible hybridisation barriers. The study was conducted in a P. radiata seed orchard in the Southern Cape (South Africa. Field data were compared to the climatic conditions at natural and commercial provenances of seven Mesoamerican Pinus species identified as possible hybrid partners. In vitro pollen studies were used to confirm whether interspecific crosses with P. radiata might be feasible within predefined climatic parameters. The temperature ranges for both top and northern side of P. radiata pine trees in the seed orchard was similar to the natural distribution of P. radiata, P. elliottii Engelm. and P. taeda L. in the USA. Results suggested that pollen of P. elliottii and P. taeda might be more suited to result in the successful pollination of P. radiata than the other Mesoamerican pine species tested in this study.  Furthermore, the combination of minimum temperature and precipitation also showed a closer correlation to successful hybridisation with P. radiata for both P. elliotii and P. taeda. However, pollen tube elongation studies did not support these results, suggesting that mean temperature might not be the only determining factor of hybridisation success. Three circadian temperature models that mimic natural conditions were developed for Karatara and Sabie (Tweefontein, Witklip and Spitskop.  These models will be tested in future in vitro studies to further evaluate temperature fluctuations between day and night regimes as a possible reproductive barrier limiting hybridisation success between P. radiata and other Mesoamerican pine species.

  16. Rheum australe D. Don: a review of its botany, ethnobotany, phytochemistry and pharmacology.

    Science.gov (United States)

    Rokaya, Maan Bahadur; Münzbergová, Zuzana; Timsina, Binu; Bhattarai, Krishna Ram

    2012-06-14

    Rheum australe D. Don (Polygonaceae) has been commonly used in traditional medicine for a wide range of ailments related to the circulatory, digestive, endocrine, respiratory and skeletal systems as well as to infectious diseases. To provide the up-to-date information that is available on the botany, traditional uses, phytochemistry, pharmacology and toxicology of Rheum australe. Additionally, to highlight the possible uses of this species to treat different diseases and to provide a basis for future research. The present review covers the literature available from 1980 to 2011. The information was collected from scientific journals, books, theses and reports via a library and electronic search (Google Scholar, Web of Science and ScienceDirect). Ethnomedical uses of Rheum australe have been recorded from China, India, Nepal and Pakistan for 57 different types of ailments. The phytochemical studies have shown the presence of many secondary metabolites belonging to anthraquinones, stilbenes, anthrones, oxantrone ethers and esters, chromones, flavonoids, carbohydrate, lignans, phenols and sterols. Crude extracts and isolated compounds from Rheum australe show a wide spectrum of pharmacological activities, such as antidiabetic, anti-inflammatory, antifungal, antimicrobial, antioxidant, anticancer, hepatoprotective and immune-enhancing activities, as well as a usefulness for improving renal function. Rheum australe has been widely used source of medicine for years without any adverse effects. Many studies have provided evidence for various traditional uses. However, there is a need for additional studies of the isolated compounds to validate the traditional uses in human models. The present review on the botany, traditional uses, phytochemistry and toxicity has provided preliminary information for further studies and commercial exploitations of the plant. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  17. "Careworkers don't have a voice:" epistemological violence in residential care for older people.

    Science.gov (United States)

    Banerjee, Albert; Armstrong, Pat; Daly, Tamara; Armstrong, Hugh; Braedley, Susan

    2015-04-01

    Drawing on feminist epistemologies, this paper attends to the way the reductionist assumptions have shaped the organization of nursing home carework in manners that are insufficient to the needs of relational care. This paper is informed by a study involving nine focus groups and a survey of Canadian residential care workers (141 RNs, 139 LPNs and 415 frontline careworkers). Four major themes were identified. Reductionist assumptions contributed to routinized, task-based approaches to care, resulting in what careworkers termed "assembly line care." Insufficient time and emphasis on the relational dimensions of care made it difficult to "treat residents as human beings." Accountability, enacted as counting and documenting, led to an "avalanche of paperwork" that took time away from care. Finally, hierarchies of knowledge contributed to systemic exclusions and the perception that "careworkers' don't have a voice." Careworkers reported distress as a result of the tensions between the organization of work and the needs of relational care. We theorize these findings as examples of "epistemological violence," a concept coined by Vandana Shiva (1988) to name the harm that results from the hegemony of reductionist assumptions. While not acting alone, we argue that reductionism has played an important role in shaping the context of care both at a policy and organizational level, and it continues to shape the solutions to problems in nursing home care in ways that pose challenges for careworkers. We conclude by suggesting that improving the quality of both work and care will require respecting the specificities of care and its unique epistemological and ontological nature. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Survey of genome sequences in a wild sweet potato, Ipomoea trifida (H. B. K.) G. Don.

    Science.gov (United States)

    Hirakawa, Hideki; Okada, Yoshihiro; Tabuchi, Hiroaki; Shirasawa, Kenta; Watanabe, Akiko; Tsuruoka, Hisano; Minami, Chiharu; Nakayama, Shinobu; Sasamoto, Shigemi; Kohara, Mitsuyo; Kishida, Yoshie; Fujishiro, Tsunakazu; Kato, Midori; Nanri, Keiko; Komaki, Akiko; Yoshinaga, Masaru; Takahata, Yasuhiro; Tanaka, Masaru; Tabata, Satoshi; Isobe, Sachiko N

    2015-04-01

    Ipomoea trifida (H. B. K.) G. Don. is the most likely diploid ancestor of the hexaploid sweet potato, I. batatas (L.) Lam. To assist in analysis of the sweet potato genome, de novo whole-genome sequencing was performed with two lines of I. trifida, namely the selfed line Mx23Hm and the highly heterozygous line 0431-1, using the Illumina HiSeq platform. We classified the sequences thus obtained as either 'core candidates' (common to the two lines) or 'line specific'. The total lengths of the assembled sequences of Mx23Hm (ITR_r1.0) was 513 Mb, while that of 0431-1 (ITRk_r1.0) was 712 Mb. Of the assembled sequences, 240 Mb (Mx23Hm) and 353 Mb (0431-1) were classified into core candidate sequences. A total of 62,407 (62.4 Mb) and 109,449 (87.2 Mb) putative genes were identified, respectively, in the genomes of Mx23Hm and 0431-1, of which 11,823 were derived from core sequences of Mx23Hm, while 28,831 were from the core candidate sequence of 0431-1. There were a total of 1,464,173 single-nucleotide polymorphisms and 16,682 copy number variations (CNVs) in the two assembled genomic sequences (under the condition of log2 ratio of >1 and CNV size >1,000 bases). The results presented here are expected to contribute to the progress of genomic and genetic studies of I. trifida, as well as studies of the sweet potato and the genus Ipomoea in general. © The Author 2015. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

  19. Don Delillo’s Point Omega; Ecstasy and Inertia in a Hyperreal World: A Baudrillardian Reading

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    Faeze Yegane

    2015-07-01

    Full Text Available This paper aims to present a Baudrillardian reading of Don Delillo’s Point Omega in the framework of Baudrillard’s definition of the contemporary world as ‘hyperreal’ and also his twin concepts of ‘ecstasy and inertia’. According to Baudrillard, the contemporary time is the hyperreal era in which subjects do not have access to ‘real’ primarily because they are supplied with the ‘simulations’ first and then with the ‘real’ entity and probably never confronted with the ‘real’ itself through media, advertisements, and virtual world. Thus, the perception they have from incidents, objects, places and even other people is ‘hyperreal’; edited, censored, beautified and exaggerated versions of reality; more real than real. In this study Point Omega will be examined as Delillo’s ‘hyperreal’ version of Alfred Hitchcock’s Psycho since the movie is screened in the course of the novel and despite the similarities between the novel and the movie they end contrastingly. Symbolically ‘real’ is not found in the novel due to ‘Mobius spiraling negativity’ which is one of the features of Baudrillard’s definition of ‘hyperreal’ age. Baudrillard believes in the triumph of objects over subjects. While the object’s world is perpetually cultivating frenziedly, objects and technologies begin to dominate the stupefied subjects consequently he states when the objects are moving toward their ‘ecstasy’, the subjects are stricken in ‘inertia’. This supremacy of objects and technologies will be displayed in Point Omega regarding Richard Elster’s inert behavior and reaching the ‘omega point’ that Teilhard de Chardin envisions for human race is rendered impossible due to Elster’s destiny in the framework of Baudrillard’s concept of evolution.

  20. Tiny cells meet big questions: a closer look at bacterial cell biology.

    Science.gov (United States)

    Goley, Erin D

    2013-04-01

    While studying actin assembly as a graduate student with Matt Welch at the University of California at Berkeley, my interest was piqued by reports of surprising observations in bacteria: the identification of numerous cytoskeletal proteins, actin homologues fulfilling spindle-like functions, and even the presence of membrane-bound organelles. Curiosity about these phenomena drew me to Lucy Shapiro's lab at Stanford University for my postdoctoral research. In the Shapiro lab, and now in my lab at Johns Hopkins, I have focused on investigating the mechanisms of bacterial cytokinesis. Spending time as both a eukaryotic cell biologist and a bacterial cell biologist has convinced me that bacterial cells present the same questions as eukaryotic cells: How are chromosomes organized and accurately segregated? How is force generated for cytokinesis? How is polarity established? How are signals transduced within and between cells? These problems are conceptually similar between eukaryotes and bacteria, although their solutions can differ significantly in specifics. In this Perspective, I provide a broad view of cell biological phenomena in bacteria, the technical challenges facing those of us who peer into bacterial cells, and areas of common ground as research in eukaryotic and bacterial cell biology moves forward.

  1. A neural model for transient identification in dynamic processes with 'don't know' response

    Energy Technology Data Exchange (ETDEWEB)

    Mol, Antonio C. de A. E-mail: mol@ien.gov.br; Martinez, Aquilino S. E-mail: aquilino@lmp.ufrj.br; Schirru, Roberto E-mail: schirru@lmp.ufrj.br

    2003-09-01

    This work presents an approach for neural network based transient identification which allows either dynamic identification or a 'don't know' response. The approach uses two 'jump' multilayer neural networks (NN) trained with the backpropagation algorithm. The 'jump' network is used because it is useful to dealing with very complex patterns, which is the case of the space of the state variables during some abnormal events. The first one is responsible for the dynamic identification. This NN uses, as input, a short set (in a moving time window) of recent measurements of each variable avoiding the necessity of using starting events. The other one is used to validate the instantaneous identification (from the first net) through the validation of each variable. This net is responsible for allowing the system to provide a 'don't know' response. In order to validate the method, a Nuclear Power Plant (NPP) transient identification problem comprising 15 postulated accidents, simulated for a pressurized water reactor (PWR), was proposed in the validation process it has been considered noisy data in order to evaluate the method robustness. Obtained results reveal the ability of the method in dealing with both dynamic identification of transients and correct 'don't know' response. Another important point studied in this work is that the system has shown to be independent of a trigger signal which indicates the beginning of the transient, thus making it robust in relation to this limitation.

  2. BMP signaling regulates satellite cell-dependent postnatal muscle growth.

    Science.gov (United States)

    Stantzou, Amalia; Schirwis, Elija; Swist, Sandra; Alonso-Martin, Sonia; Polydorou, Ioanna; Zarrouki, Faouzi; Mouisel, Etienne; Beley, Cyriaque; Julien, Anaïs; Le Grand, Fabien; Garcia, Luis; Colnot, Céline; Birchmeier, Carmen; Braun, Thomas; Schuelke, Markus; Relaix, Frédéric; Amthor, Helge

    2017-08-01

    Postnatal growth of skeletal muscle largely depends on the expansion and differentiation of resident stem cells, the so-called satellite cells. Here, we demonstrate that postnatal satellite cells express components of the bone morphogenetic protein (BMP) signaling machinery. Overexpression of noggin in postnatal mice (to antagonize BMP ligands), satellite cell-specific knockout of Alk3 (the gene encoding the BMP transmembrane receptor) or overexpression of inhibitory SMAD6 decreased satellite cell proliferation and accretion during myofiber growth, and ultimately retarded muscle growth. Moreover, reduced BMP signaling diminished the adult satellite cell pool. Abrogation of BMP signaling in satellite cell-derived primary myoblasts strongly diminished cell proliferation and upregulated the expression of cell cycle inhibitors p21 and p57 In conclusion, these results show that BMP signaling defines postnatal muscle development by regulating satellite cell-dependent myofiber growth and the generation of the adult muscle stem cell pool. © 2017. Published by The Company of Biologists Ltd.

  3. Plan de marketing para una microempresa de servicio orientada a la actividad de restaurante: caso Don Gato

    OpenAIRE

    Pérez Báez, Karolina

    2004-01-01

    Universidad de Costa Rica. Posgrado en Administración y Dirección de Empresas. Maestría Profesional en Administración y Dirección de Empresas con énfasis en Mercadeo y Ventas El objetivo general del presente trabajo fue elaborar un plan de marketing para la microempresa Don Gato que le permita redefinir su mercado, con el propósito de recomendar estrategias mediante las cuales pueda garantizar su crecimiento y mantenerse como empresa en marcha, utilizando un nuevo enfoque basado en las nec...

  4. ¡Deje hablar! La transferencia en "Las desdichas de Cardenio" de Don Quijote de la Mancha

    Directory of Open Access Journals (Sweden)

    Oswaldo Ortegón

    2012-02-01

    Full Text Available Entre los distintos estudios que relacionan la literatura de creación con el psicoanálisis clínico y su comprensión metapsicológica, se destaca el papel ilustrador del arte y la literatura en la explicación del pensamiento psicoanalítico. Este trabajo discute el concepto fundamental de la transferencia, teniendo como referente la locura de Cardenio, un personaje de Don Quijote de la Mancha. Varios elementos técnicos del quehacer psicoanalítico florecen alrededor del estudio de esta idea.

  5. LA PARODIA ENTRE LA FICCIÓN YLA REALIDAD EN EL INGENIOSO HIDALGO DON QUIJOTE DE LA MANCHA

    OpenAIRE

    Nora González Gandiaga

    2005-01-01

    En este trabajo se aborda la problemática de la ficción y de la realidad intermediada por la operación paródica en El Ingenioso Hidalgo don Quijote de La Mancha de Miguel de Cervantes Saavedra. Se asedia el texto para ver cómo la parodia y la ironía son estrategias fundamentales para leer la concepción novelesca y cómo se permite al lector avieso adentrarse en la Poética cervantina, partiendo de los paratextos: prólogo, sonetos iniciales antes de adentrarnos en el cuerpo de la novela para lue...

  6. Literatura consolatoria en torno a la muerte del príncipe don Juán

    Directory of Open Access Journals (Sweden)

    Jacobo SANZ HERMIDA

    2009-12-01

    Full Text Available Se lamentaba Juan del Encina haciéndose eco del dolor que asoló a España tras la muerte del príncipe don Juan, primogénito de los Reyes Católicos: «Fortuna nos traxo tal pena penosa/ que ágenos nos hizo de toda holganca./ Secóse la flor de nuestra esperanca,/ gran fruto esperando de planta graciosa:/ nacieron espinas; secóse la rosa;/ secóse la flor; nacieron abrojos;/ nacieron fatigas, nacieron enojos./ Murió nuestro Príncipe, joya preciosa».

  7. Linkage mapping and identification of QTL affecting deoxynivalenol (DON) content (Fusarium resistance) in oats (Avena sativa L.).

    Science.gov (United States)

    He, Xinyao; Skinnes, Helge; Oliver, Rebekah E; Jackson, Eric W; Bjørnstad, Asmund

    2013-10-01

    Mycotoxins caused by Fusarium spp. is a major concern on food and feed safety in oats, although Fusarium head blight (FHB) is often less apparent than in other small grain cereals. Breeding resistant cultivars is an economic and environment-friendly way to reduce toxin content, either by the identification of resistance QTL or phenotypic evaluation. Both are little explored in oats. A recombinant-inbred line population, Hurdal × Z595-7 (HZ595, with 184 lines), was used for QTL mapping and was phenotyped for 3 years. Spawn inoculation was applied and deoxynivalenol (DON) content, FHB severity, days to heading and maturity (DH and DM), and plant height (PH) were measured. The population was genotyped with DArTs, AFLPs, SSRs and selected SNPs, and a linkage map of 1,132 cM was constructed, covering all 21 oat chromosomes. A QTL for DON on chromosome 17A/7C, tentatively designated as Qdon.umb-17A/7C, was detected in all experiments using composite interval mapping, with phenotypic effects of 12.2–26.6 %. In addition, QTL for DON were also found on chromosomes 5C, 9D, 13A, 14D and unknown_3, while a QTL for FHB was found on 11A. Several of the DON/FHB QTL coincided with those for DH, DM and/or PH. A half-sib population of HZ595, Hurdal × Z615-4 (HZ615, with 91 lines), was phenotyped in 2011 for validation of QTL found in HZ595, and Qdon.umb-17A/7C was again localized with a phenotypic effect of 12.4 %. Three SNPs closely linked to Qdon.umb-17A/7C were identified in both populations, and one each for QTL on 5C, 11A and 13A were identified in HZ595. These SNPs, together with those yet to be identified, could be useful in marker-assisted selection to pyramiding resistance QTL.

  8. The “meta” reflection: a comparison between ironic strategies in Golden Age comedy and Don Quixote

    Directory of Open Access Journals (Sweden)

    Federica Zoppi

    2017-11-01

    Full Text Available The study examines the ironic and critical function that the “meta” reflection plays in dramatic and narrative works. In particular, a comparison is made between the metatheatrical strategies used in Golden Age comedies and the metaliterary discourse proposed by Cervantes in Don Quixote. These self-reflexive elements form part of a ludic structure of detachment and complicity that creates a dynamic and interactive relationship among author, characters and receiver. The main vehicle of this communication is the meta-character, which is projected outside the conventional confines of the work to dialogue with the spectator or the reader and to question the author’s control.

  9. Autoridad y memoria entre los killakas. Las estrategias discursivas de don Juan Colque Guarache en el sur andino (Siglo XVI)

    OpenAIRE

    Graña, Mario Julio

    2014-01-01

    Entre 1575 y 1577, don Juan Colque Guarache, cacique principal de las etnias killaka, asanaque, sivaroyo,haracapi y uruquilla del sur del lago Poopó, actual Oruro (Bolivia)eleva a consideración de las autoridades españolas una serie de "Probanzasde Méritos y Servicios" de sus antepasados. Esta fuente permite explorar la narración de la historia de un linaje indígena, a la luz de las estrategias discursivas empleadas por las autoridades étnicas dentro del contexto colonial.En este sentido, se ...

  10. Tempo e percezione in The Body Artist di Don DeLillo e Ghost Trio di Samuel Beckett

    Directory of Open Access Journals (Sweden)

    Davide Barbuscia

    2013-03-01

    Full Text Available This essay provides a critical analysis of Don DeLillo’s novel The Body Artist and Samuel Beckett’s work for television Ghost Trio. In particular it analyses the representation of time and its perception in both these works, highlighting some shared aesthetic modalities such as their attempt to depict duration through a poetics of slow motion. The essay also foregrounds how both these works give narrative form to Merleau-Ponty’s understanding of ‘time as its perception’.

  11. Density determination in Pino Radiata (D.Don) samples using 59.5 keV gamma radiation attenuation

    International Nuclear Information System (INIS)

    Dinator, Maria I.; Morales, Jose R.; Aliaga, Nelson; Karsulovic, Jose T.; Sanchez, Jaime; Leon, Adolfo

    1996-01-01

    A non destructive method to determine wood samples density is presented. The photon mass attenuation coefficient in samples of Pino radiata (D.Don) was measured at 59.5 keV with a radioactive source of Am-241. The value of 0.192 ± 0.002 cm 2 /g was obtained with a gamma spectroscopy system and later used on the determination of the mass density in sixteen samples of the same species. Comparison of these results with those of gravimetric method through a linear regression showed a slope of 1.001 and a correlation factor of 0.94. (author)

  12. Propuesta de planificación curricular del bachillerato en ciencias para la Unidad Educativa Salesiana "Don Bosco"

    OpenAIRE

    Dávila Garzón, Luis Iván

    2011-01-01

    La Propuesta de Planificación Curricular del Bachillerato en Ciencias para la Unidad Educativa Salesiana “Don Bosco”, de Quito, se inscribe en el eje pedagógico salesiano. Desde hace mucho tiempo no se ha realizado una verdadera renovación pedagógica, por lo que el CONESA, propuso un diseño curricular con enfoque holístico, sistémico y por procesos, con metodologías transdisciplinarias hacia la contextualización, totalización y vinculación de los aprendizajes, que desarrolla la educación bási...

  13. The Chronicle of Don Quixote, encrypted in Arabic and Gothic Letters, in Dialogue with the Lead Books of Granada

    Directory of Open Access Journals (Sweden)

    Kevin Matos

    2017-11-01

    Full Text Available Much to the readers’ surprise, the lost chronicle of Don Quixote is discovered in the Alcaná of Toledo’s orientalized bazaar, written in Arabic by a Muslim sage by the name of Cide Hamete Benengeli. But the mysterious Arabic history undergoes a strange metamorphosis when it is lost again and rediscovered in a sealed leaden box. Unexpectedly, the chronicle is now extant in Gothic letters. We are thus dealing with a text twice encrypted in impenetrable letters —both Arabic and Gothic—, and the present essay deals precisely with the unfathomable mystery of the chronicle’s unexpected textual confection and its literary consequences.

  14. Meeting report--Imaging the Cell.

    Science.gov (United States)

    Moreau, Violaine; Cordelières, Fabrice P; Poujol, Christel; Sagot, Isabelle; Saltel, Frédéric

    2015-11-01

    Every two years, the French Society for Cell Biology (SBCF) organises an international meeting called 'Imaging the Cell'. This year, the 8th edition was held on 24-26 June 2015 at University of Bordeaux Campus Victoire in the city of Bordeaux, France, a UNESCO World Heritage site. Over the course of three days, the meeting provided a forum for experts in different areas of cell imaging. Its unique approach was to combine conventional oral presentations during morning sessions with practical workshops at hosting institutes and the Bordeaux Imaging Center during the afternoons. The meeting, co-organised by Violaine Moreau and Frédéric Saltel (both INSERM U1053, Bordeaux, France), Christel Poujol and Fabrice Cordelières (both Bordeaux Imaging Center, Bordeaux, France) and Isabelle Sagot (Institut de Biochimie et Génétique Cellulaires, Bordeaux, France), brought together about 120 scientists including 16 outstanding speakers to discuss the latest advances in cell imaging. Thanks to recent progress in imaging technologies, cell biologists are now able to visualise, follow and manipulate cellular processes with unprecedented accuracy. The meeting sessions and workshops highlighted some of the most exciting developments in the field, with sessions dedicated to optogenetics, high-content screening, in vivo and live-cell imaging, correlative light and electron microscopy, as well as super-resolution imaging. © 2015. Published by The Company of Biologists Ltd.

  15. Features of Microsystems for Cultivation and Characterization of Stem Cells with the Aim of Regenerative Therapy.

    Science.gov (United States)

    Ahn, Kihoon; Kim, Sung-Hwan; Lee, Gi-Hun; Lee, SeungJin; Heo, Yun Seok; Park, Joong Yull

    2016-01-01

    Stem cells have infinite potential for regenerative therapy thanks to their advantageous ability which is differentiable to requisite cell types for recovery and self-renewal. The microsystem has been proved to be more helpful to stem cell studies compared to the traditional methods, relying on its advantageous feature of mimicking in vivo cellular environments as well as other profitable features such as minimum sample consumption for analysis and multiprocedures. A wide variety of microsystems were developed for stem cell studies; however, regenerative therapy-targeted applications of microtechnology should be more emphasized and gain more attractions since the regenerative therapy is one of ultimate goals of biologists and bioengineers. In this review, we introduce stem cell researches harnessing well-known microtechniques (microwell, micropattern, and microfluidic channel) in view point of physical principles and how these systems and principles have been implemented appropriately for characterizing stem cells and finding possible regenerative therapies. Biologists may gain information on the principles of microsystems to apply them to find solutions for their current challenges, and engineers may understand limitations of the conventional microsystems and find new chances for further developing practical microsystems. Through the well combination of engineers and biologists, the regenerative therapy-targeted stem cell researches harnessing microtechnology will find better suitable treatments for human disorders.

  16. ¡Deje hablar! La transferencia en «Las desdichas de Cardenio» de Don Quijote de la Mancha Let speak! Transference in «Cardenio's Grieves» from Don Quixote de la Mancha

    Directory of Open Access Journals (Sweden)

    Oswaldo Ortegón Cufiño

    2011-12-01

    Full Text Available Resumen Entre los distintos estudios que relacionan la literatura de creación con el psicoanálisis clínico y su comprensión metapsicológica, se destaca el papel ilustrador del arte y la literatura en la explicación del pensamiento psicoanalítico. Este trabajo discute el concepto fundamental de la transferencia, teniendo como referente la locura de Cardenio, un personaje de Don Quijote de La Mancha. Varios elementos técnicos del quehacer psicoanalítico florecen alrededor del estudio de esta idea.Abstract Different studies that relate creative literature to clinical psychoanalysis and its meta-psychological understanding, have highlighted the illustrative role of art and literature in the explanation of psychoanalytic thought. This paper discusses the fundamental concept of transference, using the madness of Cardenio, a character in Don Quixote de La Mancha, as a reference. Some technical elements of this psychoanalytic work are developed through the study of this idea.

  17. Colonel Don Benito Machado. A National Guards commandant on the southern frontier of Buenos Aires [1852-1880] El coronel Don Benito Machado. Un comandante de Guardias Nacionales en la frontera sur bonaerense [1852-1880

    Directory of Open Access Journals (Sweden)

    Leonardo Canciani

    2012-01-01

    Full Text Available In this work, we will analyze the National Guard regiments and the role played by their commandants during the process of national organization on the southern frontier of Buenos Aires, from the case study of coronel don José Benito Machado. First of all, our objective will be describe the specific characteristics that adopted the National Guards in the societies of the southern frontier of the province of Buenos Aires. And then, to analyze the mechanisms developed by Benito Machado to build the power bases in the region that enabled the consolidation of its leadershipEn el presente trabajo, analizamos los regimientos de Guardias Nacionales y las funciones que desempeñaron sus comandantes durante el proceso de organización nacional en la frontera sur bonaerense, desde el estudio de caso del coronel don José Benito Machado. En primer lugar, repasamos las características específicas que adoptaron las Guardias Nacionales en las sociedades de la frontera sur de la provincia de Buenos Aires; mientras que, en segundo lugar, analizamos los diversos mecanismos desarrollados por Benito Machado para construir las bases de poder en la región que posibilitaron el afianzamiento de su liderazgo

  18. La actuación política de don Juan de Borbón ante el fallecimiento de Franco

    Directory of Open Access Journals (Sweden)

    Jaime Cosgaya García

    2005-01-01

    Full Text Available La designación de don Juan Carlos en julio de 1969 como sucesor en la jefatura del Estado, a título de Rey, modificó sustancialmente las relaciones que hasta entonces habían mantenido Franco y don Juan, y colocó en una nueva situación a padre e hijo, situados a partir de ese instante en posiciones políticas diversas y en cierto modo contrarias. Sin embargo, la actuación política que desarrolló don Juan de Borbón desde ese momento hasta el fallecimiento de Franco, fue la de un colaborador discreto y eficaz de su hijo. Esta comunicación estudia dos proyectos que demuestran esta línea de comportamiento del conde de Barcelona. Ambos se originaron ante la proximidad del fallecimiento de Franco y tuvieron como punto en común la participación de Antonio Fontán. El primer encargo fue la redacción de una posible declaración a la muerte del general en julio de 1974, que finalmente no se hizo pública; y el segundo consistió en la mediación de esta personalidad monárquica para manifestar a don Juan Carlos —a los pocos días de ser proclamado Rey— su intención de renunciar a los derechos dinásticos de los que era depositario por el testamento de Alfonso XIII.The appointment of don Juan Carlos in July 1969 as forthcoming Head of State — King of Spain— changed dramatically the relationship between Franco and Don Juan. On the other hand, a new relationship between father and son appeared and, thereinafter, they will hold different —and, to some extent— conflicting political positions. Nevertheless, Don Juan de Borbón from that moment until to Franco’s death played the role of a discreet and effective assistant. This paper studies two facts within this political behaviour of Barcelona’s Count. Both of them stemmed from the possible death of Franco, playing Antonio Fontán a prominent role in both of them. The first task was a possible speech after Franco’s death in July 1974 which was not finally published. The second

  19. Las representaciones de Don Gaspar de Haro y Guzmán, VII Marqués del Carpio: retratos, alegorías y emblemas

    Directory of Open Access Journals (Sweden)

    López-Fanjul y Díez del Corral, María

    2013-12-01

    Full Text Available The author studies various portraits of Don Gaspar de Haro y Guzmán, 7th Marquis of Carpio, and analyses the strong links that they had with his interest in drawing, emblems, allegories, and the search for fame through books.Este artículo está dedicado a estudiar una serie de retratos de Don Gaspar de Haro y Guzmán, VII Marqués del Carpio, especialmente importantes por su relación con el dibujo, las alegorías, los emblemas y la búsqueda de la fama a través de los libros.

  20. Do trichothecenes reduce viability of circulating blood cells and modify haemostasis parameters?

    Science.gov (United States)

    Froquet, R; Arnold, F; Batina, P; Parent-Massin, D

    2003-01-01

    This manuscript describes the results of experiments conducted using human blood cells to determine the ability of T-2 toxin and DON to cause changes in clotting time, platelet aggregation, red blood cell haemolysis, RBC glucose content, lactate release, glutathione depletion, as well as white blood cell viability. In vitro results showed that haemostasis parameters and erythrocytes were not affected at concentrations able to induce inhibition of haematopoietic progenitor proliferation. In the presence of 10(-8) M and 10(-6) M T-2, the leucocyte number decreased at 24 h by 30% and 50% respectively. A 50% decrease in leucocyte number was observed for 10(-5) M DON. Results were compared with haematopoietic progenitor sensitivities. Due to the differences in sensitivities between mature blood cells and haematopoietic progenitors, haematological problems associated with trichothecene intoxication could be attributed to haematopoiesis inhibition.

  1. Rediscovering Don Swanson: The Past, Present and Future of Literature-based Discovery

    Directory of Open Access Journals (Sweden)

    Neil R. Smalheiser

    2017-12-01

    Full Text Available Purpose: The late Don R. Swanson was well appreciated during his lifetime as Dean of the Graduate Library School at University of Chicago, as winner of the American Society for Information Science Award of Merit for 2000, and as author of many seminal articles. In this informal essay, I will give my personal perspective on Don’s contributions to science, and outline some current and future directions in literature-based discovery that are rooted in concepts that he developed. Design/methodology/approach: Personal recollections and literature review. Findings: The Swanson A-B-C model of literature-based discovery has been successfully used by laboratory investigators analyzing their findings and hypotheses. It continues to be a fertile area of research in a wide range of application areas including text mining, drug repurposing, studies of scientific innovation, knowledge discovery in databases, and bioinformatics. Recently, additional modes of discovery that do not follow the A-B-C model have also been proposed and explored (e.g. so-called storytelling, gaps, analogies, link prediction, negative consensus, outliers, and revival of neglected or discarded research questions. Research limitations: This paper reflects the opinions of the author and is not a comprehensive nor technically based review of literature-based discovery. Practical implications: The general scientific public is still not aware of the availability of tools for literature-based discovery. Our Arrowsmith project site maintains a suite of discovery tools that are free and open to the public (http://arrowsmith.psych.uic.edu, as does BITOLA which is maintained by Dmitar Hristovski (http:// http://ibmi.mf.uni-lj.si/bitola, and Epiphanet which is maintained by Trevor Cohen (http://epiphanet.uth.tmc.edu/. Bringing user-friendly tools to the public should be a high priority, since even more than advancing basic research in informatics, it is vital that we ensure that scientists

  2. An intimate understanding of place: Charles Sauriol and Toronto’s Don River Valley, 1927-1989.

    Science.gov (United States)

    Bonnell, Jennifer

    2011-01-01

    Every summer from 1927 to 1968, Toronto conservationist Charles Sauriol and his family moved from their city home to a rustic cottage just a few kilometres away, within the urban wilderness of Toronto’s Don River Valley. In his years as a cottager, Sauriol saw the valley change from a picturesque setting of rural farms and woodlands to an increasingly threatened corridor of urban green space. His intimate familiarity with the valley led to a lifelong quest to protect it. This paper explores the history of conservation in the Don River Valley through Sauriol’s experiences. Changes in the approaches to protecting urban nature, I argue, are reflected in Sauriol’s personal experience – the strategies he employed, the language he used, and the losses he suffered as a result of urban planning policies. Over the course of Sauriol’s career as a conservationist, from the 1940s to the 1990s, the river increasingly became a symbol of urban health – specifically, the health of the relationship between urban residents and the natural environment upon which they depend. Drawing from a rich range of sources, including diary entries, published memoirs, and unpublished manuscripts and correspondence, this paper reflects upon the ways that biography can inform histories of place and better our understanding of individual responses to changing landscapes.

  3. Le don après un décès d'origine cardiocirculatoire au Canada

    Science.gov (United States)

    Shemie, Sam D.; Baker, Andrew J.; Knoll, Greg; Wall, William; Rocker, Graeme; Howes, Daniel; Davidson, Janet; Pagliarello, Joe; Chambers-Evans, Jane; Cockfield, Sandra; Farrell, Catherine; Glannon, Walter; Gourlay, William; Grant, David; Langevin, Stéphan; Wheelock, Brian; Young, Kimberly; Dossetor, John

    2006-01-01

    Résumé Ces recommandations sont le fruit d'un processus multidisciplinaire national ayant duré un an et visant à déterminer si et comment l'on pourrait procéder au don d'organes après un décès d'origine cardiocirculatoire («don après le décès cardiocirculatoire», ou DDC) au Canada. Le forum national organisé en février 2005 a permis aux participants de discuter et d'élaborer des recommandations sur les principes, interventions et pratiques se rapportant au DDC. Les aspects éthiques et juridiques ont été abordés dans les discussions. À la fin du Forum, la majorité des participants ont été favorables à l'implantation de programmes de DDC au Canada. Les participants du Forum ont également convenu qu'il fallait formuler et prôner des valeurs fondamentales pour orienter l'élaboration de programmes et de protocoles basés sur le cadre médical, éthique et juridique établi lors de cette réunion. Même si la possibilité d'un don d'organes et de tissus doit faire partie intégrante des soins de fin de vie, il faut insister sur le fait que le devoir de diligence envers les patients mourants et leurs familles doit demeurer la priorité des équipes soignantes. La complexité et les répercussions profondes du décès sont reconnues et doivent être respectées, de même que les différences personnelles, ethnoculturelles et religieuses face à la mort et au don d'organes. Les décisions d'arrêter le traitement de maintien des fonctions vitales, la prise en charge des derniers moments de la vie et le diagnostic de décès selon des critères cardiocirculatoires doivent être distincts et indépendants des processus de don et transplantation. Ce rapport contient des recommandations destinées aux gestionnaires de program, aux autorités sanitaires régionales et aux instances appelés à élaborer les protocoles de DDC. Les programmes doivent être conçus en fonction des éléments suivants : direction et planification locales, éducation et

  4. A possibilistic approach for transient identification with 'don't know' response capability optimized by genetic algorithm

    International Nuclear Information System (INIS)

    Almeida, Jose Carlos S. de; Schirru, Roberto; Pereira, Claudio M.N.A.; Universidade Federal, Rio de Janeiro, RJ

    2002-01-01

    This work describes a possibilistic approach for transient identification based on the minimum centroids set method, proposed in previous work, optimized by genetic algorithm. The idea behind this method is to split the complex classification problem into small and simple ones, so that the performance in the classification can be increased. In order to accomplish that, a genetic algorithm is used to learn, from realistic simulated data, the optimized time partitions, which the robustness and correctness in the classification are maximized. The use of a possibilistic classification approach propitiates natural and consistent classification rules, leading naturally to a good heuristic to handle the 'don't know 'response, in case of unrecognized transient, which is fairly desirable in transient classification systems where safety is critical. Application of the proposed approach to a nuclear transient indentification problem reveals good capability of the genetic algorithm in learning optimized possibilistic classification rules for efficient diagnosis including 'don't know' response. Obtained results are shown and commented. (author)

  5. Iconographic analysis of the covers of school editions of Don Quijote between the Second Republic and Francoism

    Directory of Open Access Journals (Sweden)

    Luis Rodrigo Martín

    2016-11-01

    Full Text Available Don Quixote is the most recognized work of Spanish and universal literature, and teaching adaptations in schools are very important for children to understand their reading. Compulsory reading of the work during the period between the Second Republic and the Franco regime caused many school adaptations to suit their classroom teaching. This study focused on the graphic elements of the work from a communicative and iconographic perspective, allows through content analysis of a cataloged and representative sample of the covers of school adaptations, verify that the hard political interventionism that suffered the work according antagonistic dominant ideologies did not influence their design, because these spaces were not ideologically charged, despite being the first element of commercial persuasion of the book and its role motivate reading. Analytical data along with historical explain the existence of a commercial image of Quixote free of ideological connotations (on the cover, from his iconographic path, which we have not found significant differences from the two dominant ideologies. However, the politicization of the work contributed to Don Quixote became the national hero of children and adults and a universal benchmark of behavior full of great ethical and moral values.

  6. UMTRA water sampling technical (peer) review: Responses to observations, comments, and recommendations submitted by Don Messinger (Roy F. Weston, Inc.)

    International Nuclear Information System (INIS)

    1993-08-01

    An independent technical review (peer review) was conducted during the period of September 15--17, 1992. The review was conducted by C. Warren Ankerberg (Geraghty and Miller, Inc., Tampa, Florida) and Don Messinger (Roy F. Weston, Inc., West Chester, Pennsylvania). The review was held at Jacobs Engineering in Albuquerque, New Mexico, and at the Shiprock, New Mexico, site. The peer review included a review of written documentation [water sampling standard operating procedures (SOP)], an inspection of technical reports and other deliverables, a review of staff qualifications and training, and a field visit to evaluate the compliance of field procedures with SOPS. Upon completion of the peer review, each reviewer independently prepared a report of findings from the review. The reports listed findings and recommended actions. This document responds to the observations, comments, and recommendations submitted by Don Messinger following his review. The format of this document is to present the findings and recommendations verbatim from Mr. Messinger's report, followed by responses from the UMTRA Project staff. Included in the responses from the UMTRA Project staff are recommended changes in SOPs and strategies for implementing the charges

  7. SPIRou Input Catalogue: global properties of 440 M dwarfs observed with ESPaDOnS at CFHT

    Science.gov (United States)

    Fouqué, Pascal; Moutou, Claire; Malo, Lison; Martioli, Eder; Lim, Olivia; Rajpurohit, Arvind; Artigau, Etienne; Delfosse, Xavier; Donati, Jean-François; Forveille, Thierry; Morin, Julien; Allard, France; Delage, Raphaël; Doyon, René; Hébrard, Elodie; Neves, Vasco

    2018-04-01

    Present and future high-precision radial-velocity spectrometers dedicated to the discovery of low-mass planets orbiting low-mass dwarfs need to focus on the best selected stars to make an efficient use of telescope time. In the framework of the preparation of the SPIRou Input Catalogue (SPIC), the CoolSnap program aims at screening M dwarfs in the solar neighbourhood against binarity, rapid rotation, activity, etc. To optimize the selection, this paper describes the methods used to compute effective temperature, metallicity, projected rotation velocity of a large sample of 440 M dwarfs observed in the visible with the high-resolution spectropolarimeter Echelle SpectroPolArimetric Device for the ObservatioN of Stars (ESPaDOnS) at Canada-France-Hawaii Telescope. It also summarizes known and newly discovered spectroscopic binaries, and stars known to belong to visual multiple systems. A calibration of the projected rotation velocity versus measured line widths for M dwarfs observed by the ESPaDOnS spectropolarimeter is derived, and the resulting values are compared to equatorial rotation velocities deduced from rotation periods and radii. A comparison of the derived effective temperatures and metallicities with literature values is also conducted. Finally, the radial-velocity uncertainty of each star in the sample is estimated, to narrow down the selection of stars to be included into the SPIC.

  8. Don Miguel Samper: la ética y el espíritu de empresa en el siglo XIX

    Directory of Open Access Journals (Sweden)

    Luis Ernesto Romero Ortíz

    1988-04-01

    Full Text Available RESUMEN El presente artículo relaciona el concepto de ética y moral con la actividad empresarial a través del análisis que se hace del pensamiento de Don Miguel Samper Agudelo, empresario exitoso y uno de los mayores ideólogos liberales de la segunda mitad del siglo XIX. Con una visión weberiana sobre el comportamiento empresarial, se busca destacar el papel que los valores tienen sobre la iniciativa empresarial tomado como base el conocido ensayo “La miseria en Bogotá”, escrito por don Miguel Samper, en el cual de manera implícita y explícita  las más de las veces, el autor deja expuesta su visión acerca de la moral como determinante en el desarrollo económico de una sociedad. Se indican los aspectos formadores de la ética empresarial que según Miguel Samper aportó la cultura eclesiástica, las instituciones educativas  y la cultura política imperante  en la segunda mitad del siglo XIX en  Colombia.

  9. Tsunami survivors' perspectives on vulnerability and vulnerability reduction: evidence from Koh Phi Phi Don and Khao Lak, Thailand.

    Science.gov (United States)

    Steckley, Marylynn; Doberstein, Brent

    2011-07-01

    This paper presents the results of primary research with 40 survivors of the 2004 Indian Ocean tsunami in two communities: Khao Lak (n=20) and Koh Phi Phi Don (n=20), Thailand. It traces tsunami survivors' perceptions of vulnerability, determines whether residents felt that the tsunami affected different communities differently, identifies the populations and sub-community groups that survivors distinguished as being more vulnerable than others, highlights community-generated ideas about vulnerability reduction, and pinpoints a range of additional vulnerability reduction actions. Tsunami survivors most consistently identified the 'most vulnerable' community sub-populations as women, children, the elderly, foreigners, and the poor. In Khao Lak, however, respondents added 'Burmese migrants' to this list, whereas in Koh Phi Phi Don, they added 'Thai Muslims'. Results suggest that the two case study communities, both small, coastal, tourism-dominated communities no more than 100 kilometres apart, have differing vulnerable sub-groups and environmental vulnerabilities, requiring different post-disaster vulnerability reduction efforts. © 2011 The Author(s). Disasters © Overseas Development Institute, 2011.

  10. Primordial germ cells: the first cell lineage or the last cells standing?

    Science.gov (United States)

    Johnson, Andrew D; Alberio, Ramiro

    2015-08-15

    Embryos of many animal models express germ line determinants that suppress transcription and mediate early germ line commitment, which occurs before the somatic cell lineages are established. However, not all animals segregate their germ line in this manner. The 'last cell standing' model describes primordial germ cell (PGC) development in axolotls, in which PGCs are maintained by an extracellular signalling niche, and germ line commitment occurs after gastrulation. Here, we propose that this 'stochastic' mode of PGC specification is conserved in vertebrates, including non-rodent mammals. We postulate that early germ line segregation liberates genetic regulatory networks for somatic development to evolve, and that it therefore emerged repeatedly in the animal kingdom in response to natural selection. © 2015. Published by The Company of Biologists Ltd.

  11. Comparison of the molecular effects of the mycotoxins beta-zearalenol and deoxynivalenol in porcine endometrial cells--a review.

    Science.gov (United States)

    Wollenhaupt, Karin; Tomek, W; Tiemann, Ute

    2007-03-01

    The mycotoxins beta-zearalenol (beta-ZOL) and deoxynivalenol (DON) produce toxic effects that result in diseases in humans and animals. The molecular mechanisms that control the mycotoxin-mediated effects are far from being completely understood. Various results show that these mycotoxins could inhibit cell proliferation. In the present short communication, the influence of beta-ZOL and DON on the abundance and phosphorylation state of kinases that are included in regulation of the initiation of mRNA translation (which is correlated with cell proliferation) was compared in porcine endometrial cells (PEC). Our results indicate that these mycotoxins modulate the expression and phosphorylation of these factors in a different manner. Whereas beta-ZOL mainly had an impact on the biological activity of the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2), protein kinase B (Akt), eukaryotic initiation factor 4E (eIF4E) and its repressor 4E binding protein 1 (4E-BP1), DON reduced the abundance of p38 MAPk, Akt and specific 4E-BP1 bands. In summary, these results indicate that beta-ZOL influences molecular events that are included in the initiation of mRNA translation in the porcine endometrium but DON does not alter such processes clearly.

  12. We Don't Get Any Training: The Impact of a Professional Development Model on Teaching Practices of Chemistry and Biology Graduate Teaching Assistants

    Science.gov (United States)

    Mutambuki, Jacinta M.; Schwartz, Renee

    2018-01-01

    This study investigated the implementation of best teaching practices by science graduate teaching assistants [GTAs] (3 chemists and 2 biologists) in five inquiry-based, interdisciplinary chemistry-biology experiments during a six-week professional development (PD) program, Engage PD. Additionally, we examined GTAs' experiences in implementing…

  13. Brain delivery of the glutamine antagonist 6-Diazo-5-oxo-L-norleucine (DON) via prodrug approach: a potential treatment for HIV-associated neurocognitive disorders (HAND)

    Czech Academy of Sciences Publication Activity Database

    Nedelcovych, M.; Kim, B. H.; Rais, R.; Jančařík, Andrej; Tenora, Lukáš; Alt, J.; Kelschenbach, J.; Majer, Pavel; Volsky, D.; Slusher, B.

    2016-01-01

    Roč. 22, Suppl 1 (2016), S57-S58 ISSN 1355-0284. [International Symposium on NeuroVirology /14./. 25.10.2016-28.10.2016, Toronto] Institutional support: RVO:61388963 Keywords : glutamate * DON * HAND treatment Subject RIV: CC - Organic Chemistry

  14. "This Is My Body Which Will Be Given up for You": Federico Garcia Lorca's "Amor de Don Perlimplin" and the "Auto Sacramental" Tradition

    Science.gov (United States)

    Badenes, Jose Ignacio

    2009-01-01

    "Amor de Don Perlimplin con Belisa en su jardin" is one of Federico Garcia Lorca's shortest plays as well as one of his deepest. Its theme is love, particularly the interaction between spiritual longing and carnal desire, body and soul, humanity and divinity. These are aspects found in Roman Catholic Eucharistic theology which the…

  15. Muusikamaailm : Praemium Imperiale kätteandmine. Vanamuusika päevad Hernes. Uus ooper Don Quijotest. Soome muusikud Münchenis / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    1999-01-01

    Jaapani kunstide auhinna "Praemium Imperiale" laureaatidest. Lääne-Saksa Raadio festivalist "Herne", tänavu pealkirja all "Spiel auf, Europa!". C. Halffteri uudisooper "Don Quijote" tuleb maailmaesiettekandele Madridis 2000. a. veebruaris. Soome muusikute kontsertidest sügishooajal Baierimaal ja Münchenis

  16. Don Bartolomé Lobo Guerrero. Inquisidor y tercer arzobispo de Santafé de Bogotá (1599-1609) (Reseña)

    OpenAIRE

    Luque-Alcaide, E. (Elisa)

    1997-01-01

    Reseña del libro de Luis Carlos MANTILLA RUIZ, Don Bartolomé Lobo Guerrero. Inquisidor y tercer arzobispo de Santafé de Bogotá (1599-1609), Academia Colombiana de Historia («Biblioteca de Historia Nacional», v. CXLVII), Santafé de Bogotá 1996, 320 pp.

  17. Transmission and Preservation of music of the Laos Vieng Ethnics Group at Tumbol Don kha, U-thong Distric SuphanBuri province

    Directory of Open Access Journals (Sweden)

    Nuttapot Pocharoen

    2016-10-01

    Full Text Available Music Vieng, Laos, Vientiane, Lao ethnic group identity. And this is something that represents the cultural and traditional beliefs from the past, which is very important and plays a role in Vientiane, Lao ethnic group. Today This research aims to 1. To study the music of ethnic Lao Wiang Thong, Suphan Buri Province Don Kha 2. To study the musical heritage and preservation of ethnic groups in Laos Vieng Thong, Suphan Buri Province Don Kha. The results showed that the music of ethnic Lao Wiang Thong, Suphan Buri Province Don Kha. Originally a folk music as well as the East. Originally, Canada is the main instrument. Vientiane, Laos ethnic group influenced society. And culture outside to inside. The group of friends and was popular with the younger generation. Lack of support from local organizations People who know less. Make music, ethnic Vieng, Laos began to fade with time. ceremony, a ritual is believed the disease. Similar to the medium by a worship of ancestors. Conservation and musical heritage of ethnic groups in Laos Don Kha Vieng Thong, Suphan Buri. Are passed down from generation to generation through teaching, saying to each other in kinship. There are performances at various events Playing music in various applications And shows for visitors to watch.

  18. Low soil water and nutrient availability below New Zealand kauri ( Agathis australis (D. Don) Lindl.) trees increase the relative fitness of kauri seedlings

    NARCIS (Netherlands)

    Verkaik, E.; Berendse, F.; Gardner, R.O.

    2007-01-01

    Tree species can affect the soil they are growing on and this might influence their fitness. The New Zealand gymnosperm tree species kauri (Agathis australis (D. Don) Lindl.) which grows in mixed angiosperm¿gymnosperm forests has a substantial effect upon the soil. We studied the hypotheses that:

  19. Don Quijote de la Mancha, de Rafael Gil: una adaptación literaria del cine español en las conmemoraciones cervantinas de 1947

    Directory of Open Access Journals (Sweden)

    María del Mar Mañas Martínez

    2006-12-01

    – Differences caused by ideological reasons. The differences that try to adapt the Cervantes text to the ideological requirements of the “Franquismo”. We can find: the idealization and glorification of Don Quixote, the disappearance of scatological elements, the disappearance or modification of subversive elements (for example the ones related to the Muslim universe, and the simple and plain ideological manipulation.

  20. Helping Teams Succeed: An Essay Review of "Groups That Work (and Those That Don't): Creating Conditions for Effective Teamwork."

    Science.gov (United States)

    Kain, Daniel L.

    1993-01-01

    Teams are incompatible with the scientific management philosophy underlying traditional curricular and organizational theory. This article examines J. R. Hackman's book "Groups That Work (and Those That Don't): Creating Conditions for Effective Teamwork" (1990), as it illuminates the experience of teaching on a middle school…

  1. Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche.

    Science.gov (United States)

    Wang, Xiaoxi; Page-McCaw, Andrea

    2018-02-07

    Stem cells reside in a niche, a local environment whose cellular and molecular complexity is still being elucidated. In Drosophila ovaries, germline stem cells depend on cap cells for self-renewing signals and physical attachment. Germline stem cells also contact the anterior escort cells, and here we report that anterior escort cells are absolutely required for germline stem cell maintenance. When escort cells die from impaired Wnt signaling or hid expression, the loss of anterior escort cells causes loss of germline stem cells. Anterior escort cells function as an integral niche component by promoting DE-cadherin anchorage and by transiently expressing the Dpp ligand to promote full-strength BMP signaling in germline stem cells. Anterior escort cells are maintained by Wnt6 ligands produced by cap cells; without Wnt6 signaling, anterior escort cells die leaving vacancies in the niche, leading to loss of germline stem cells. Our data identify anterior escort cells as constituents of the germline stem cell niche, maintained by a cap cell-produced Wnt6 survival signal. © 2018. Published by The Company of Biologists Ltd.

  2. MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells.

    Science.gov (United States)

    Van Itallie, Christina M; Tietgens, Amber Jean; Aponte, Angel; Gucek, Marjan; Cartagena-Rivera, Alexander X; Chadwick, Richard S; Anderson, James M

    2018-02-02

    Treatment of epithelial cells with interferon-γ and TNF-α (IFN/TNF) results in increased paracellular permeability. To identify relevant proteins mediating barrier disruption, we performed proximity-dependent biotinylation (BioID) of occludin and found that tagging of MARCKS-related protein (MRP; also known as MARCKSL1) increased ∼20-fold following IFN/TNF administration. GFP-MRP was focused at the lateral cell membrane and its overexpression potentiated the physiological response of the tight junction barrier to cytokines. However, deletion of MRP did not abrogate the cytokine responses, suggesting that MRP is not required in the occludin-dependent IFN/TNF response. Instead, our results reveal a key role for MRP in epithelial cells in control of multiple actin-based structures, likely by regulation of integrin signaling. Changes in focal adhesion organization and basal actin stress fibers in MRP-knockout (KO) cells were reminiscent of those seen in FAK-KO cells. In addition, we found alterations in cell-cell interactions in MRP-KO cells associated with increased junctional tension, suggesting that MRP may play a role in focal adhesion-adherens junction cross talk. Together, our results are consistent with a key role for MRP in cytoskeletal organization of cell contacts in epithelial cells. © 2018. Published by The Company of Biologists Ltd.

  3. Effects of aluminum on DNA synthesis, cellular polyamines, polyamine biosynthetic enzymes and inorganic ions in cell suspension cultures of a woody plant, Catharanthus roseus

    Science.gov (United States)

    Rakesh Minocha; Subhash C. Minocha; Stephanie L. Long; Walter C. Shortle

    1992-01-01

    Increased aluminum (Al) solubility in soil waters due to acid precipitation has aroused considerable interest in the problem of Al toxicity in plants. In the present study, an in vitro suspension culture system of Catharanthus roseus (L.) G. Don was used to analyze the effects of aluminum on several biochemical processes in these cells. The aliphatic...

  4. Scientific basis for use of Pyrus pashia Buch.-Ham. ex D. Don. fruit in gastrointestinal, respiratory and cardiovascular ailments.

    Directory of Open Access Journals (Sweden)

    Khalid Hussain Janbaz

    Full Text Available Pyrus pashia Buch.-Ham. ex D. Don. has been used conventionally by many communities in the Himalayan region for the management of gastrointestinal, respiratory, and vascular complications. Set against this background, this study was carried out to justify the scientific basis to validate folkloric uses of fruits of Pyrus pashia Buch.-Ham. ex D. Don. (Pp.Cr in traditional systems of medicine.The crude ethanol extract of fruits of Pyrus pashia Buch.-Ham. ex D. Don. (Pp.Cr was tested in vitro on isolated rabbit jejunum, tracheal, and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with a PowerLab data acquisition system.The Pp.Cr on application (0.01-5.0 mg/ml to isolated rabbit jejunum preparation exhibited relaxation through decrease in magnitude and frequency of spontaneous contractions. The Pp.Cr also exerted a relaxant (0.01-5.0 mg/ml effect on K+ (80 mM induced contractions in isolated rabbit jejunum preparations and caused shifting of the Ca2+ curves (1.0-3.0 mg/ml toward right in a manner similar to that of verapamil (3 μM, possibly suggesting presence of Ca2+ channel blocking activity. Subsequently, Pp.Cr in a concentration-dependent fashion (0.01-10.0 mg/ml caused relaxation of CCh (1 μM and K+ (80 mM induced contractions in isolated rabbit tracheal preparations in a manner comparable to that of dicyclomine, suggesting that the observed relaxant effect is likely to be mediated through antimuscarinic and/or Ca2+ channel blocking activities. Moreover, when evaluated against isolated rabbit aortic preparations, the Pp.Cr in concentrations up to 10 mg/ml exhibited a contractile response that was found to be abolished subsequent to pretreatment of isolated tissue preparation with cyproheptadine (1 μM, phentolamine (1 μM, and losartan (1 μM, suggesting that Pp.Cr may have some α-adrenergic, muscarinic, serotonergic, and angiotensin II activities.The aqueous ethanolic extract of Pyrus pashia

  5. Reflexiones sobre la empresa cultural del rey Don Sancho IV de Castilla

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    Bizzarri, Hugo O.

    2001-06-01

    Full Text Available In the last times we have seen the reappraisal of the cultural period during the last quarter of the XIII Century, specially in that concerning to the participation of king Sancho IV in the patronage of the artistic works (literary as architectonic and in considering this epoch as a period of flowering of tendencies which signed the culture of XIV Century. This provoked the revision by the critics of the King Bravo's role in this cultural renewal and the intent of outlining an intellectual group around him or even to sustain the influence of the queen Doña María de Molina. At the same time, it was accepted the existence of a "cultural model" which binds together all the manifestations of this epoch. The present work poses a series of reflexions about two aspects of the culture of this period: to search external signs to the king Don Sancho's artistic works which let perceive the clue of a real king's patronage, and, finally, to consider ideological aspects of these works, which even without denying the unity of this cultural model, present it as the fruit of heterogeneous working groups.

    Dans ces dernières années, on a revalorisé certains aspects du domaine culturel de la fìn du XIIIe siècle, tout en particulier le patronage du roi Sancho IV des belles lettres et de l'architecture et sa participation dans le développement de tendances qui ont marqué la culture du XIVe siècle. Ces constatation ont entraîné, dune part, un nouvel analyse du rôle du roi brave dans cet épanouissement culturel et, d'autre part, l'examen du groupe intellectuel construit autour du roi ainsi que la possible ingérence de la reine Doña María de Molina dans cet équipe. Tandis que ces recherches se développaient, on a confirmé l´existence d'un modèle culturel qui englobe toutes les manifestations de cette époque. Cet article examine deux points capitaux de la culture de cette période: dune part on cherchera des signes extérieurs dans les

  6. Propagação vegetativa de Brunfelsia uniflora (Pohl. D. Don. (Manacá.

    Directory of Open Access Journals (Sweden)

    Michelle Melissa Althaus-Ottmann

    2006-06-01

    Full Text Available O manacá (Brunfelsia uniflora (Pohl. D. Don. – Solanaceae é um arbusto nativo do Brasil, de grande potencial ornamental. Apesar disso, há poucas informações bibliográficas a respeito de sua propagação. Neste trabalho, foi estudada a propagação vegetativa da espécie pelos processos de estaquia caulinar e alporquia. Para a estaquia, foi analisada a indução do enraizamento de estacas semilenhosas pela aplicação de ácido indol butírico (AIB em talco (controle, 1000 mg kg-1, 2000 mg kg-1 e 4000 mg kg-1 e em solução (controle, 1.000 mg L-1, 2.000 mg L-1 e 4000 mg L-1. Para a alporquia, foi analisada a indução do enraizamento de alporques pela aplicação de AIB em pasta de lanolina (controle, 1.500 mg kg-1 e 3.000 mg kg-1. O experimento de estaquia foi avaliado após 60 e 120 dias da instalação, considerando-se as variáveis: porcentagem de estacas enraizadas, número de raízes formadas/estaca, comprimento das três maiores raízes formadas/estaca, porcentagem de estacas vivas não enraizadas, de estacas com calos e de estacas mortas. O experimento de alporquia foi avaliado após 60 dias, considerando-se as variáveis: porcentagem de alporques enraizados; número de raízes formadas/ alporque; comprimento das três maiores raízes formadas/alporque, porcentagem de alporques com calos, de alporques vivos não enraizados e de alporques mortos. No experimento de estaquia, na primeira avaliação, não houve diferença significativa para a variável porcentagem de estacas enraizadas, sendo a maior porcentagem de 10,0% (controle em solução. Na segunda avaliação, observou-se um aumento na porcentagem de enraizamento (41,94% para o mesmo tratamento. No experimento de alporquia, não foi verificada diferença significativa entre os tratamentos para nenhuma variável testada, sendo a maior porcentagem de alporques enraizados de 5,60% (3.000 mg kg-1. O enraizamento de Brunfelsia uniflora, tanto na estaquia como na alporquia, foi

  7. Don't end up in the fields: identity construction among Mexican adolescent immigrants, their parents, and sociocontextual processes.

    Science.gov (United States)

    Maciel, Jose A; Knudson-Martin, Carmen

    2014-10-01

    This grounded theory study of 16 Mexican immigrant adolescents and 20 of their parents examines how they construct relational identities within their families, at school, with friends, and in the larger society. Results focus on a core identity bind faced by the adolescents: immigration messages from parents that say, "don't be like me" and the societal message, "you're not like us." Response to this bind was guided by two contrasting sets of identity narratives: Empowering narratives invited an intentional approach to school and life choices. Restricting narratives maintained an ambivalent approach to school and life choices. Resolution of the identity bind was a collective, ongoing process that has implications for Mexican immigrant families and the professionals who work with them. © 2013 American Association for Marriage and Family Therapy.

  8. Celebrations III and IV Centenary of Don Quixote in Spanish America through the Spanish press from 1905 to 2005

    Directory of Open Access Journals (Sweden)

    María Ángeles Chaparro Domínguez

    2012-12-01

    Full Text Available This article analyzes the coverage that the Spanish press provided to Spanish American celebrations for the Third and Fourth Centenary of the publication of the first part of Don Quixote, events that took place in 1905 and 2005, respectively. By the study of a total of twenty-one newspapers, which include El Imparcial, El Liberal and La Correspondencia de España, of the first period, and El País, El Mundo and La Vanguardia of the second, we will find out how they lived both centenaries in Spanish America, how important were these tributes in the press and, furthermore, we will know the concrete symbolic meaning that the popular Spanish nobleman acquired in either period.

  9. Living in a simulacrum: how TV and the supermarket redefines reality in Don DeLillo’s White Noise

    Directory of Open Access Journals (Sweden)

    Ghashmari, Ahmad

    2010-07-01

    Full Text Available This paper examines the impact of simulation, hyperreality, and consumerism on Don Delillo's novel "White Noise". It discusses how the novel pictures technology and mass media as an empire of signs and codes that erase or implode meaning. TV, radio reports and tidbits, and medical imaging devices are intertwined with many aspects of people's lives in this late capitalist culture. Futhermore, the paper will shed some light on the issue of hyperreality which is generated by simulations. We will see how this new type of reality becomes more real than reality itself. Then, the influence of the supermarket and the emergence of consumer culture will be discussed. We will see how production and consumption have gained a new different meaning in this new "superficial" society and how it reshapes people's undestanding and interaction with reality.

  10. A propósito de los dibujos inéditos del Instituto Valencia de Don Juan

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    Ocaña Martínez, José Antonio

    2001-06-01

    Full Text Available El Instituto Valencia de Don Juan, constituido notarialmente en 1916 conforme a las ideas de Guillermo Joaquín de Osma y Scull (La Habana, 1853-Madrid, 1922, casado con la última condesa de dicho título, Adelaida Crooke y Guzman (Madrid, 1863-París, 1918, guarda, en un reformado palacete de la calle Fortuny de Madrid, importantes colecciones de pinturas, esculturas, tapices, bordados, armas, azulejos, loza, alfarería, azabaches, monedas, muebles, libros y documentos, que el matrimonio logró reunir, provenientes de sus antepasados y adquiridos por ellos. Entre tan valiosos fondos casi pasan desapercibidos los veintiocho dibujos, que hemos catalogado recientemente, los cuales no pueden considerarse una colección sino un conjunto de piezas que llegaron aleatoriamente a la Institución, la mayoría de procedencia hoy desconocida, realizados entre principios de los siglos XVI y XX.…

  11. CCD CBERS and ASTER data in dasometric characterization of Pinus radiata D. Don (north-western Spain

    Directory of Open Access Journals (Sweden)

    Eva Sevillano-Marco

    2013-03-01

    Full Text Available A Chinese-Brazilian Earth Resources Satellite (CBERS and an Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER scenes coupled with ancillary georeferenced data and field survey were employed to examine the potential of the remote sensing data in stand basal area, volume and aboveground biomass assessment over large areas of Pinus radiata D. Don plantations in Northwestern Spain. Statistical analysis proved that the near infrared band and the shade fraction image showed significant correlation coefficients with all stand variables considered. Predictive models were accordingly selected and utilized to undertake the spatial distribution of stand variables in radiata stands delimited by the National Forestry Map. The study reinforces the potentiality of remote sensing techniques in a cost-effective assessment of forest systems.

  12. The genesis of Don Quixote and Sancho Panza as comic types, between Spain and France, until 1642

    Directory of Open Access Journals (Sweden)

    Agapita Jurado Santos

    2017-11-01

    Full Text Available The laughter theme would create some humorous characters who played a leading role in interludes and entremeses. However, these types evolved into more complex genres as comedy and tragicomedy. A mocking and primitive laughter ushered in a more elaborated comicality, reflected on topics as love, the self-perception or inanity. Also, several kinds of madness are explored: that of love, the specular madness or just pure insanity, which could lead either into disaster, or into a luminous craziness. The chivalric tradition and literary style beyond the Pyrenees would impose a decorum that lead to a process of stylization and moralization in Don Quixote, Sancho and Dulcinea, as a result a triumphant hedonism emerged, becoming the foundation of the novel reception.

  13. Primer and interviews: The dynamic stem cell niche.

    Science.gov (United States)

    Kiefer, Julie C

    2011-03-01

    A stem cell niche is a microenvironment that supports self-renewal of a population of stem cells, and their production of differentiated cells. While the definition evokes images of a stem cell Shangri-La-where a serene stem cell pool nestles within a niche that shelters and sustains it-the reality is much more tumultuous. Niches are subject to an ever-changing maelstrom of environmental factors, the ravages of old age, and the sly tactics of disease. Presented here is a basic overview of the different ways in which stem cell niches respond to local and systemic environments, and their impact on stem cell behavior. The primer culminates with a discussion of the topic with stem cell and niche biologists D. Leanne Jones, Ph.D., and Tudorita Tumbar, Ph.D. Copyright © 2011 Wiley-Liss, Inc.

  14. LA PARODIA ENTRE LA FICCIÓN YLA REALIDAD EN EL INGENIOSO HIDALGO DON QUIJOTE DE LA MANCHA

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    Nora González Gandiaga

    2005-11-01

    Full Text Available En este trabajo se aborda la problemática de la ficción y de la realidad intermediada por la operación paródica en El Ingenioso Hidalgo don Quijote de La Mancha de Miguel de Cervantes Saavedra. Se asedia el texto para ver cómo la parodia y la ironía son estrategias fundamentales para leer la concepción novelesca y cómo se permite al lector avieso adentrarse en la Poética cervantina, partiendo de los paratextos: prólogo, sonetos iniciales antes de adentrarnos en el cuerpo de la novela para luego calar en éste. En todo este cometido colaboran los narradores ficticios para "leer" la novela moderna que postula Cervantes en el libro e incluso se advierte que los distintos narradores dejan al descubierto la parodia y al mismo tiempo permiten un juego crítico-reflexivo en la materia textualThis paper examines the problematic of fiction and reality as mediated by parody in Cervantes’ Don Quijote de la Mancha. The approach to the text is meant to see how parody and irony become fundamental strategies to understand the novelistic concept, and how the perceptive reader is permitted to enter into the Cervantine poetic, starting from the paratexts: the Prologue; the opening sonnets, before getting into the core of the work discriminatingly. In all this procedure fictitious narrators collaborate in the reading of the modernistic novel which Cervantes postulated. It may also be noticed how the different narrators disclose the parodic while allowing a critical-reflexive play in the text

  15. Geological and environmental observations in the Sunchales Creek and Tonco River , Don Otto uranium mine, Salta Province

    International Nuclear Information System (INIS)

    Gorustovich, S.; Guidi, F.; Bárbaro, N.; Nievas, H.; Tomellini, G.

    2013-01-01

    Results of geological and environmental observations made by professionals of the Comisión Nacional de Energía Atómica (CNEA) down streams Don Otto uranium mine on the Sunchales creek, from Los Guanacos strait down to the Tonco river mouth, and from river mouth down to narrow pass named Salto Grande, are presented in this report. La Yesera, Las Curtiembres and Los Blanquitos Formations of the Pirgua Subgroup, and Lecho and Yacoraite Formations of the Balbuena Subgroup crops out in that area (Salta Group, Cretaceous- Middle Eocene). Water stream analyses have given uranium contents between 890 μg/L and 1,100 μg/L, and uranium in stream sediments between 4 μg/g and 14 μg/g; radimetric anomalias up to 1,500 c/s in discoloured facies of the Las Curtiembres Formation, and 2,000 c/s in dark pelitic sediments of the Yacoraite Formation. A new zone with uranium traces in Curtiembres Formation belonging to the Pirgua Subgroup has been identified in the Alemanía cretaceous basin, which is stratigraphically similar to Cajoncillo, Las Abritas and El Fraile deposits. Those traces in addition to the other ones localized in the upper third of the Yacoraite Formation would have been originated by the geochemical uranium anomalies in waters and stream sediments by uranium leaching of rocks. The geochemical uranium anomalies in water and sediments are not a consequence of the antropic activity of the uranium mining carried out in Don Otto mine (1961-1982). (authors) [es

  16. Suitport Feasibility - Human Pressurized Space Suit Donning Tests with the Marman Clamp and Pneumatic Flipper Suitport Concepts

    Science.gov (United States)

    Boyle, Robert M.; Rodriggs, Liana; Allton, Charles; Jennings, Mallory; Aitchision, Lindsay

    2013-01-01

    The suitport concept has been recently implemented as part of the small pressurized lunar rover (Currently the Space Exploration vehicle, or SEV) and the Multi-Mission Space Exploration Vehicle (MMSEV) concept demonstrator vehicle. Suitport replaces or augments the traditional airlock function of a spacecraft by providing a bulkhead opening, capture mechanism, and sealing system to allow ingress and egress of a space suit while the space suit remains outside of the pressurized volume of the spacecraft. This presents significant new opportunities to EVA exploration in both microgravity and surface environments. The suitport concept will enable three main improvements in EVA by providing reductions in: pre-EVA time from hours to less than thirty minutes; airlock consumables; contamination returned to the cabin with the EVA crewmember. Two second generation suitports were designed and tested. The previously reported second generation Marman Clamp suitport and a newer concept, the Pneumatic Flipper Suitport. These second generation suitports demonstrated human donning and doffing of the Z1 spacesuit with an 8.3 psi pressure differential across the spacesuit. Testing was performed using the JSC B32 Chamber B, a human rated vacuum chamber. The test included human rated suitports, the suitport compatible prototype suit, and chamber modifications. This test brought these three elements together in the first ever pressurized donning of a rear entry suit through a suitport. This paper presents the results of the testing, including unexpected difficulties with doffing, and engineering solutions implemented to ease the difficulties. A review of suitport functions, including a discussion of the need to doff a pressurized suit in earth gravity, is included. Recommendations for future design and testing are documented.

  17. Suitport Feasibility - Human Pressurized Space Suit Donning Tests with the Marmon Clamp and Pneumatic Flipper Suitport Concepts

    Science.gov (United States)

    Boyle, Robert M.; Rodriggs, Liana; Alton, Charles; Jennings, Mallory; Aitchison, Lindsay

    2012-01-01

    The suitport concept has been recently implemented as part of the small pressurized lunar rover (Currently the Space Exploration vehicle, or SEV) and the Multi-Mission Space Exploration Vehicle (MMSEV) concept demonstrator vehicle. Suitport replaces or augments the traditional airlock function of a spacecraft by providing a bulkhead opening, capture mechanism, and sealing system to allow ingress and egress of a space suit while the space suit remains outside of the pressurized volume of the spacecraft. This presents significant new opportunities to EVA exploration in both microgravity and surface environments. The suitport concept will enable three main improvements in EVA by providing reductions in: pre-EVA time from hours to less than thirty minutes; airlock consumables; contamination returned to the cabin with the EVA crewmember. Two second generation suitports were designed and tested. The previously reported second generation Marman Clamp suitport and a newer concept, the Pneumatic Flipper Suitport. These second generation suitports demonstrated human donning and doffing of the Z1 spacesuit with an 8.3 psi pressure differential across the spacesuit. Testing was performed using the JSC B32 Chamber B, a human rated vacuum chamber. The test included human rated suitports, the suitport compatible prototype suit, and chamber modifications. This test brought these three elements together in the first ever pressurized donning of a rear entry suit through a suitport. This paper presents the results of the testing, including unexpected difficulties with doffing, and engineering solutions implemented to ease the difficulties. A review of suitport functions, including a discussion of the need to doff a pressurized suit in earth gravity, is included. Recommendations for future design and testing are documented.

  18. Séroprévalence des marqueurs viraux sur les dons du sang au Centre de Transfusion Sanguine, Hôpital Militaire d’Instruction Mohammed V de Rabat

    Science.gov (United States)

    Uwingabiye, Jean; Zahid, Hafidi; Unyendje, Loubet; Hadef, Rachid

    2016-01-01

    Le but de ce travail était de déterminer la prévalence du virus de l’immunodéficience humaine (VIH), du virus de l’hépatite B (VHB) et C (VHC) sur les dons du sang collectés au Centre de transfusion sanguine(CTS) de l’hôpital militaire d’instruction Mohammed V entre 2010 et 2012. Etude rétrospective menée auprès des donneurs de sang militaires âgés de 18 à 50 ans avec prédominance masculine (95%). L’entretien médical pré-don constitue la première barrière de sélection des sujets à risque. Le dépistage biologique était réalisé par technique immuno-enzymatique en milieu liquide utilisant des anticorps et/ou des antigènes. L’ELISA (enzyme linked immuno-sorbent assay) combiné de quatrième génération pour VHC et VIH a été utilisé. La confirmation a été faite en réalisant la même technique en double au CTS et au laboratoire de virologie. Dans notre série de 25661 échantillons testés, la prévalence du VHB était 3,97‰ (n=102), celle de VHC était 2,45 ‰ (n=63), celle de VIH était 0,15 ‰ (n=4). Un seul cas de coïnfection (0,039 ‰) par le VHB et VHC a été noté, aucune association entre VIH-VHB, VIH-VHC ou VHB, VHC et VIH n’a été enregistrée. Les taux faibles de séroprévalence des marqueurs viraux de notre étude montrent l’amélioration des mesures préventives en ce qui concerne la sélection des donneurs et des tests de dépistage. Cette prévalence constatée incite à maintenir l’utilisation du réactif combiné qui est la seule alternative à la biologie moléculaire pour les pays en voie de développement. PMID:28292147

  19. Stomach development, stem cells and disease.

    Science.gov (United States)

    Kim, Tae-Hee; Shivdasani, Ramesh A

    2016-02-15

    The stomach, an organ derived from foregut endoderm, secretes acid and enzymes and plays a key role in digestion. During development, mesenchymal-epithelial interactions drive stomach specification, patterning, differentiation and growth through selected signaling pathways and transcription factors. After birth, the gastric epithelium is maintained by the activity of stem cells. Developmental signals are aberrantly activated and stem cell functions are disrupted in gastric cancer and other disorders. Therefore, a better understanding of stomach development and stem cells can inform approaches to treating these conditions. This Review highlights the molecular mechanisms of stomach development and discusses recent findings regarding stomach stem cells and organoid cultures, and their roles in investigating disease mechanisms. © 2016. Published by The Company of Biologists Ltd.

  20. Communicating the molecular basis of cancer cell-by-cell: an interview with Tatsushi Igaki.

    Science.gov (United States)

    Igaki, Tatsushi

    2015-12-01

    Tatsushi Igaki is currently based at the Kyoto University Graduate School of Biostudies, where he leads a research group dedicated to using Drosophila genetics to build a picture of the cell-cell communications underlying the establishment and maintenance of multicellular systems. His work has provided insight into the molecular bases of cell competition in the context of development and tumorigenesis, including the landmark discovery that oncogenic cells communicate with normal cells in the tumor microenvironment to induce tumor progression in a non-autonomous fashion. In this interview, he describes his career path, highlighting the shift in his research focus from the basic principles of apoptosis to clonal evolution in cancer, and also explains why Drosophila provides a powerful model system for studying cancer biology. © 2015. Published by The Company of Biologists Ltd.