WorldWideScience

Sample records for cell based sensors

  1. A magnetic cell-based sensor.

    Science.gov (United States)

    Wang, Hua; Mahdavi, Alborz; Tirrell, David A; Hajimiri, Ali

    2012-11-07

    Cell-based sensing represents a new paradigm for performing direct and accurate detection of cell- or tissue-specific responses by incorporating living cells or tissues as an integral part of a sensor. Here we report a new magnetic cell-based sensing platform by combining magnetic sensors implemented in the complementary metal-oxide-semiconductor (CMOS) integrated microelectronics process with cardiac progenitor cells that are differentiated directly on-chip. We show that the pulsatile movements of on-chip cardiac progenitor cells can be monitored in a real-time manner. Our work provides a new low-cost approach to enable high-throughput screening systems as used in drug development and hand-held devices for point-of-care (PoC) biomedical diagnostic applications.

  2. Mammalian Cell-Based Sensor System

    Science.gov (United States)

    Banerjee, Pratik; Franz, Briana; Bhunia, Arun K.

    Use of living cells or cellular components in biosensors is receiving increased attention and opens a whole new area of functional diagnostics. The term "mammalian cell-based biosensor" is designated to biosensors utilizing mammalian cells as the biorecognition element. Cell-based assays, such as high-throughput screening (HTS) or cytotoxicity testing, have already emerged as dependable and promising approaches to measure the functionality or toxicity of a compound (in case of HTS); or to probe the presence of pathogenic or toxigenic entities in clinical, environmental, or food samples. External stimuli or changes in cellular microenvironment sometimes perturb the "normal" physiological activities of mammalian cells, thus allowing CBBs to screen, monitor, and measure the analyte-induced changes. The advantage of CBBs is that they can report the presence or absence of active components, such as live pathogens or active toxins. In some cases, mammalian cells or plasma membranes are used as electrical capacitors and cell-cell and cell-substrate contact is measured via conductivity or electrical impedance. In addition, cytopathogenicity or cytotoxicity induced by pathogens or toxins resulting in apoptosis or necrosis could be measured via optical devices using fluorescence or luminescence. This chapter focuses mainly on the type and applications of different mammalian cell-based sensor systems.

  3. Electrochemical As(III) whole-cell based biochip sensor.

    Science.gov (United States)

    Cortés-Salazar, Fernando; Beggah, Siham; van der Meer, Jan Roelof; Girault, Hubert H

    2013-09-15

    The development of a whole-cell based sensor for arsenite detection coupling biological engineering and electrochemical techniques is presented. This strategy takes advantage of the natural Escherichia coli resistance mechanism against toxic arsenic species, such as arsenite, which consists of the selective intracellular recognition of arsenite and its pumping out from the cell. A whole-cell based biosensor can be produced by coupling the intracellular recognition of arsenite to the generation of an electrochemical signal. Hereto, E. coli was equipped with a genetic circuit in which synthesis of beta-galactosidase is under control of the arsenite-derepressable arsR-promoter. The E. coli reporter strain was filled in a microchip containing 16 independent electrochemical cells (i.e. two-electrode cell), which was then employed for analysis of tap and groundwater samples. The developed arsenic-sensitive electrochemical biochip is easy to use and outperforms state-of-the-art bacterial bioreporters assays specifically in its simplicity and response time, while keeping a very good limit of detection in tap water, i.e. 0.8ppb. Additionally, a very good linear response in the ranges of concentration tested (0.94ppb to 3.75ppb, R(2)=0.9975 and 3.75 ppb to 30ppb, R(2)=0.9991) was obtained, complying perfectly with the acceptable arsenic concentration limits defined by the World Health Organization for drinking water samples (i.e. 10ppb). Therefore, the proposed assay provides a very good alternative for the portable quantification of As (III) in water as corroborated by the analysis of natural groundwater samples from Swiss mountains, which showed a very good agreement with the results obtained by atomic absorption spectroscopy.

  4. Cell-Based Odorant Sensor Array for Odor Discrimination Based on Insect Odorant Receptors.

    Science.gov (United States)

    Termtanasombat, Maneerat; Mitsuno, Hidefumi; Misawa, Nobuo; Yamahira, Shinya; Sakurai, Takeshi; Yamaguchi, Satoshi; Nagamune, Teruyuki; Kanzaki, Ryohei

    2016-07-01

    The olfactory system of living organisms can accurately discriminate numerous odors by recognizing the pattern of activation of several odorant receptors (ORs). Thus, development of an odorant sensor array based on multiple ORs presents the possibility of mimicking biological odor discrimination mechanisms. Recently, we developed novel odorant sensor elements with high sensitivity and selectivity based on insect OR-expressing Sf21 cells that respond to target odorants by displaying increased fluorescence intensity. Here we introduce the development of an odorant sensor array composed of several Sf21 cell lines expressing different ORs. In this study, an array pattern of four cell lines expressing Or13a, Or56a, BmOR1, and BmOR3 was successfully created using a patterned polydimethylsiloxane film template and cell-immobilizing reagents, termed biocompatible anchor for membrane (BAM). We demonstrated that BAM could create a clear pattern of Sf21 sensor cells without impacting their odorant-sensing performance. Our sensor array showed odorant-specific response patterns toward both odorant mixtures and single odorant stimuli, allowing us to visualize the presence of 1-octen-3-ol, geosmin, bombykol, and bombykal as an increased fluorescence intensity in the region of Or13a, Or56a, BmOR1, and BmOR3 cell lines, respectively. Therefore, we successfully developed a new methodology for creating a cell-based odorant sensor array that enables us to discriminate multiple target odorants. Our method might be expanded into the development of an odorant sensor capable of detecting a large range of environmental odorants that might become a promising tool used in various applications including the study of insect semiochemicals and food contamination.

  5. CMOS based sensor for dielectric spectroscopy of biological cell suspension

    Science.gov (United States)

    Guha, S.; Schmalz, K.; Meliani, C.; Wenger, Ch

    2013-04-01

    In this work we investigate the use of microwave frequency range to measure the concentration of cells in a biological cell suspension. A theoretical model is discussed and the advantage of high frequency, which is to avoid dispersion mechanisms due to the cell parameters at lower frequencies (for example membrane capacitance), has been described. Interdigitated capacitor (IDC) has been proposed as the sensor for analysing the concentration of a cell species in the suspension. The read-out circuit is a VCO using the IDC and a pair of inductors as resonator. The capacitance of the IDC which is the function of the permittivity of the biological cell suspension determines the resonant frequency of the LC tank oscillator. Thus the concentration of cells in a solution, affecting its permittivity, is read out as the frequency of the oscillator.

  6. Soluble adenylyl cyclase is an acid-base sensor in epithelial base-secreting cells.

    Science.gov (United States)

    Roa, Jinae N; Tresguerres, Martin

    2016-08-01

    Blood acid-base regulation by specialized epithelia, such as gills and kidney, requires the ability to sense blood acid-base status. Here, we developed primary cultures of ray (Urolophus halleri) gill cells to study mechanisms for acid-base sensing without the interference of whole animal hormonal regulation. Ray gills have abundant base-secreting cells, identified by their noticeable expression of vacuolar-type H(+)-ATPase (VHA), and also express the evolutionarily conserved acid-base sensor soluble adenylyl cyclase (sAC). Exposure of cultured cells to extracellular alkalosis (pH 8.0, 40 mM HCO3 (-)) triggered VHA translocation to the cell membrane, similar to previous reports in live animals experiencing blood alkalosis. VHA translocation was dependent on sAC, as it was blocked by the sAC-specific inhibitor KH7. Ray gill base-secreting cells also express transmembrane adenylyl cyclases (tmACs); however, tmAC inhibition by 2',5'-dideoxyadenosine did not prevent alkalosis-dependent VHA translocation, and tmAC activation by forskolin reduced the abundance of VHA at the cell membrane. This study demonstrates that sAC is a necessary and sufficient sensor of extracellular alkalosis in ray gill base-secreting cells. In addition, this study indicates that different sources of cAMP differentially modulate cell biology.

  7. Cell-based capacitance sensor for analysis of EGFR expression on cell membrane

    Science.gov (United States)

    Shin, Dong-Myeong; Shin, Yong-Cheol; Ha, Ji Hye; Lee, Jong-Ho; Han, Dong-Wook; Kim, Jong-Man; Kim, Hyung Kook; Hwang, Yoon-Hwae

    2013-02-01

    Cancer cells have many kinds of cancer biomarkers. Among them, the epidermal growth factor (EGF) receptors can show a possibility for a cancer marker because the over-expression of EGF receptor is related with fibrous, colorectal, cervical and gastric tumorigenesis. We fabricated the capacitance sensor with a gap area of 50 μm × 200 μm by using photolithography and lift-off method. Using the capacitance sensor, we investigated the time dependent capacitance changes of different kinds of fibrous cells, such as HT1080 fibrosarcoma, L-929 fibroblast cell line and nHDF dermal fibroblast primary cell. We found that when we put the EGF, the capacitance decreased due to the immobilization of EGF to EGF receptor on the cell membrane. The quantitative determination of EGF receptor level for various fibrous cells was carried out and the results showed good correlation with conventional method. Based on our results, we suggest that the capacitance sensor can measure the expression level of the EGF receptor on cell membrane and be a good candidate as a cancer diagnosis.

  8. Smart Temperature Sensor for Thermal Testing of Cell-Based ICs

    CERN Document Server

    Bota, S A; Rossello, J L; Segura, J

    2011-01-01

    In this paper we present a simple and efficient built-in temperature sensor for thermal monitoring of standard-cell based VLSI circuits. The proposed smart temperature sensor uses a ring-oscillator composed of complex gates instead of inverters to optimize their linearity. Simulation results from a 0.18$\\mu$m CMOS technology show that the non-linearity error of the sensor can be reduced when an adequate set of standard logic gates is selected.

  9. High-content analysis of single cells directly assembled on CMOS sensor based on color imaging.

    Science.gov (United States)

    Tanaka, Tsuyoshi; Saeki, Tatsuya; Sunaga, Yoshihiko; Matsunaga, Tadashi

    2010-12-15

    A complementary metal oxide semiconductor (CMOS) image sensor was applied to high-content analysis of single cells which were assembled closely or directly onto the CMOS sensor surface. The direct assembling of cell groups on CMOS sensor surface allows large-field (6.66 mm×5.32 mm in entire active area of CMOS sensor) imaging within a second. Trypan blue-stained and non-stained cells in the same field area on the CMOS sensor were successfully distinguished as white- and blue-colored images under white LED light irradiation. Furthermore, the chemiluminescent signals of each cell were successfully visualized as blue-colored images on CMOS sensor only when HeLa cells were placed directly on the micro-lens array of the CMOS sensor. Our proposed approach will be a promising technique for real-time and high-content analysis of single cells in a large-field area based on color imaging.

  10. QCL-based TDLAS sensor for detection of NO toward emission measurements from ovarian cancer cells

    Science.gov (United States)

    Köhring, M.; Huang, S.; Jahjah, M.; Jiang, W.; Ren, W.; Willer, U.; Caneba, C.; Yang, L.; Nagrath, D.; Schade, W.; Tittel, F. K.

    2014-10-01

    The development of a sensitive sensor for detecting nitric oxide (NO) emissions from biological samples is reported. The sensor is based on tunable diode laser absorption spectroscopy (TDLAS) using a continuous wave, thermoelectrically cooled quantum cascade laser (QCL) and a 100-m astigmatic Herriot cell. A 2 f-wavelength modulation spectroscopy technique was used to obtain QCL-based TDLAS NO emission measurements with an optimum signal-to-noise ratio. An absorption line at 1,900.076 cm-1 was targeted to measure NO with a minimum detection limit of 124 ppt. Positive control measurements with the NO donor DETA NONOate were performed to determine and optimize the sensor performance for measurements of biological samples. Our measurements with NO donor show the potential suitability of the sensor for monitoring NO emission from cancer cells for biological investigations.

  11. A Multi-Modality CMOS Sensor Array for Cell-Based Assay and Drug Screening.

    Science.gov (United States)

    Chi, Taiyun; Park, Jong Seok; Butts, Jessica C; Hookway, Tracy A; Su, Amy; Zhu, Chengjie; Styczynski, Mark P; McDevitt, Todd C; Wang, Hua

    2015-12-01

    In this paper, we present a fully integrated multi-modality CMOS cellular sensor array with four sensing modalities to characterize different cell physiological responses, including extracellular voltage recording, cellular impedance mapping, optical detection with shadow imaging and bioluminescence sensing, and thermal monitoring. The sensor array consists of nine parallel pixel groups and nine corresponding signal conditioning blocks. Each pixel group comprises one temperature sensor and 16 tri-modality sensor pixels, while each tri-modality sensor pixel can be independently configured for extracellular voltage recording, cellular impedance measurement (voltage excitation/current sensing), and optical detection. This sensor array supports multi-modality cellular sensing at the pixel level, which enables holistic cell characterization and joint-modality physiological monitoring on the same cellular sample with a pixel resolution of 80 μm × 100 μm. Comprehensive biological experiments with different living cell samples demonstrate the functionality and benefit of the proposed multi-modality sensing in cell-based assay and drug screening.

  12. Fabrication and characterization of artificial hair cell sensor based on MWCNT-PDMS composite

    Science.gov (United States)

    Kim, Chi Yeon; Lee, Hyun Sup; Cho, Yo Han; Joh, Cheeyoung; Choi, Pyung; Park, Seong Jin

    2011-06-01

    The aim of this work is to design and fabricate a flow sensor using an artificial hair cell (AHC) inspired by biological hair cells of fish. The sensor consists of a single cilium structure with high aspect ratio and a mechanoreceptor using force sensitive resistor (FSR). The cilium structure is designed for capturing a drag force with direction due to flow field around the sensor and the mechanoreceptor is designed for sensing the drag force with direction from the cilium structure and converting it into an electric signal. The mechanoreceptor has a symmetric four electrodes to sense the drag force and its direction. To fabricate the single cilium structure with high aspect ratio, we have proposed a new design concept using a separated micro mold system (SMS) fabricated by the LIGA process. For a successful replication of the cilium structure, we used the hot embossing process with the help of a double-sided mold system. We used a composite of multiwall carbon nanotube and polydimethylsiloxane (MWCNT-PDMS). The performance of the mechanoreceptors was measured by a computer-controlled nanoindenter. We carried out several experiments with the sensor in the different flow rate and direction using the experimental test apparatus. To calibrate the sensor and calculate the velocity with direction based the signal from the sensor, we analyzed the coupled phenomena between flow field and the cilium structure to calculate the deflection of the cilium structure and the drag force applying to the cilium structure due to the flow field around sensor.

  13. Ultrasensitive flow sensing of a single cell using graphene-based optical sensors.

    Science.gov (United States)

    Xing, Fei; Meng, Gui-Xian; Zhang, Qian; Pan, Lei-Ting; Wang, Peng; Liu, Zhi-Bo; Jiang, Wen-Shuai; Chen, Yongsheng; Tian, Jian-Guo

    2014-06-11

    On the basis of the polarization-dependent absorption of graphene under total internal reflection, we designed a graphene-based optical refractive index sensor with high resolution of 1.7 × 10(-8) and sensitivity of 4.3 × 10(7) mV/RIU, as well as an extensive dynamic range. This highly sensitive graphene optical sensor enables label-free, live-cell, and highly accurate detection of a small quantity of cancer cells among normal cells at the single-cell level and the simultaneous detection and distinction of two cell lines without separation. It provides an accurate statistical distribution of normal and cancer cells with fewer cells. This facile and highly sensitive sensing refractive index may expand the practical applications of the biosensor.

  14. Live cell refractometry based on non-SPR microparticle sensor.

    Science.gov (United States)

    Liu, Chang; Chen, David D Y; Yu, Lirong; Luo, Yong

    2013-06-01

    Unlike the nanoparticles with surface plasmon resonance, the optical response of polystyrene microparticles (PSMPs) is insensitive to the chemical components of the surrounding medium under the wavelength-dependent differential interference contrast microscopy. This fact is exploited for the measurement of the refractive index of cytoplasm in this study. PSMPs of 400 nm in diameter were loaded into the cell to contact cytoplasm seamlessly, and the refractive index information of cytoplasm could be extracted by differential interference contrast microscopy operated at 420 nm illumination wavelength through the contrast analysis of PSMPs images.

  15. Real-time Bacterial Detection by Single Cell Based Sensors UsingSynchrotron FTIR Spectromicroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Veiseh, Mandana; Veiseh, Omid; Martin, Michael C.; Bertozzi,Carolyn; Zhang, Miqin

    2005-08-10

    Microarrays of single macrophage cell based sensors weredeveloped and demonstrated for real time bacterium detection bysynchrotron FTIR microscopy. The cells were patterned on gold-SiO2substrates via a surface engineering technique by which the goldelectrodes were immobilized with fibronectin to mediate cell adhesion andthe silicon oxide background were passivated with PEG to resist proteinadsorption and cell adhesion. Cellular morphology and IR spectra ofsingle, double, and triple cells on gold electrodes exposed tolipopolysaccharide (LPS) of different concentrations were compared toreveal the detection capabilities of these biosensors. The single-cellbased sensors were found to generate the most significant IR wave numbervariation and thus provide the highest detection sensitivity. Changes inmorphology and IR spectrum for single cells exposed to LPS were found tobe time- and concentration-dependent and correlated with each other verywell. FTIR spectra from single cell arrays of gold electrodes withsurface area of 25 mu-m2, 100 mu-m2, and 400 mu-m2 were acquired usingboth synchrotron and conventional FTIR spectromicroscopes to study thesensitivity of detection. The results indicated that the developedsingle-cell platform can be used with conventional FTIRspectromicroscopy. This technique provides real-time, label-free, andrapid bacterial detection, and may allow for statistic and highthroughput analyses, and portability.

  16. Electrochemical K-562 cells sensor based on origami paper device for point-of-care testing.

    Science.gov (United States)

    Ge, Shenguang; Zhang, Lina; Zhang, Yan; Liu, Haiyun; Huang, Jiadong; Yan, Mei; Yu, Jinghua

    2015-12-01

    A low-cost, simple, portable and sensitive paper-based electrochemical sensor was established for the detection of K-562 cell in point-of-care testing. The hybrid material of 3D Au nanoparticles/graphene (3D Au NPs/GN) with high specific surface area and ionic liquid (IL) with widened electrochemical windows improved the good biocompatibility and high conductivity was modified on paper working electrode (PWE) by the classic assembly method and then employed as the sensing surface. IL could not only enhance the electron transfer ability but also provide sensing recognition interface for the conjugation of Con A with cells, with the cell capture efficiency and the sensitivity of biosensor strengthened simultaneously. Concanavalin A (Con A) immobilization matrix was used to capture cells. As proof-of-concept, the paper-based electrochemical sensor for the detection of K-562 cells was developed. With such sandwich-type assay format, K-562 cells as model cells were captured on the surface of Con A/IL/3D AuNPs@GN/PWE. Con A-labeled dendritic PdAg NPs were captured on the surface of K-562 cells. Such dendritic PdAg NPs worked as catalysts promoting the oxidation of thionine (TH) by H2O2 which was released from K-562 cells via the stimulation of phorbol 12-myristate-13-acetate (PMA). Therefore, the current signal response was dependent on the amount of PdAg NPs and the concentration of H2O2, the latter of which corresponded with the releasing amount from cells. So, the detection method of K-562 cell was also developed. Under optimized experimental conditions, 1.5×10(-14) mol of H2O2 releasing from each cell was calculated. The linear range and the detection limit for K-562 cells were determined to be 1.0×10(3)-5.0×10(6) cells/mL and 200 cells/mL, respectively. Such as-prepared sensor showed excellent analytical performance with good fabrication reproducibility, acceptable precision and satisfied accuracy, providing a novel protocol in point-of-care testing of cells.

  17. Protein-specific localization of a rhodamine-based calcium-sensor in living cells.

    Science.gov (United States)

    Best, Marcel; Porth, Isabel; Hauke, Sebastian; Braun, Felix; Herten, Dirk-Peter; Wombacher, Richard

    2016-06-28

    A small synthetic calcium sensor that can be site-specifically coupled to proteins in living cells by utilizing the bio-orthogonal HaloTag labeling strategy is presented. We synthesized an iodo-derivatized BAPTA chelator with a tetramethyl rhodamine fluorophore that allows further modification by Sonogashira cross-coupling. The presented calcium sensitive dye shows a 200-fold increase in fluorescence upon calcium binding. The derivatization with an aliphatic linker bearing a terminal haloalkane-function by Sonogashira cross-coupling allows the localization of the calcium sensor to Halo fusion proteins which we successfully demonstrate in in vitro and in vivo experiments. The herein reported highly sensitive tetramethyl rhodamine based calcium indicator, which can be selectively localized to proteins, is a powerful tool to determine changes in calcium levels inside living cells with spatiotemporal resolution.

  18. Vehicle Based Vector Sensor

    Science.gov (United States)

    2015-09-28

    300001 1 of 16 VEHICLE-BASED VECTOR SENSOR STATEMENT OF GOVERNMENT INTEREST [0001] The invention described herein may be manufactured and...unmanned underwater vehicle that can function as an acoustic vector sensor . (2) Description of the Prior Art [0004] It is known that a propagating...mechanics. An acoustic vector sensor measures the particle motion via an accelerometer and combines Attorney Docket No. 300001 2 of 16 the

  19. Quantifying oxygen in paper-based cell cultures with luminescent thin film sensors.

    Science.gov (United States)

    Boyce, Matthew W; Kenney, Rachael M; Truong, Andrew S; Lockett, Matthew R

    2016-04-01

    Paper-based scaffolds are an attractive material for generating 3D tissue-like cultures because paper is readily available and does not require specialized equipment to pattern, cut, or use. By controlling the exchange of fresh culture medium with the paper-based scaffolds, we can engineer diffusion-dominated environments similar to those found in spheroids or solid tumors. Oxygen tension directly regulates cellular phenotype and invasiveness through hypoxia-inducible transcription factors and also has chemotactic properties. To date, gradients of oxygen generated in the paper-based cultures have relied on cellular response-based readouts. In this work, we prepared a luminescent thin film capable of quantifying oxygen tensions in apposed cell-containing paper-based scaffolds. The oxygen sensors, which are polystyrene films containing a Pd(II) tetrakis(pentafluorophenyl)porphyrin dye, are photostable, stable in culture conditions, and not cytotoxic. They have a linear response for oxygen tensions ranging from 0 to 160 mmHg O2, and a Stern-Volmer constant (K sv) of 0.239 ± 0.003 mmHg O2 (-1). We used these oxygen-sensing films to measure the spatial and temporal changes in oxygen tension for paper-based cultures containing a breast cancer line that was engineered to constitutively express a fluorescent protein. By acquiring images of the oxygen-sensing film and the fluorescently labeled cells, we were able to approximate the oxygen consumption rates of the cells in our cultures.

  20. Construction and application of riboswitch-based sensors that detect metabolites within bacterial cells.

    Science.gov (United States)

    Fowler, Casey C; Li, Yingfu

    2014-01-01

    A riboswitch is an RNA element that detects the level of a specific metabolite within the cell and regulates the expression of co-transcribed genes. By fusing a riboswitch to a reporter protein in a carefully designed and tested construct, this ability can be exploited to create an intracellular sensor that detects the level of a particular small molecule within live bacterial cells. There is a great deal of flexibility in the design of such a sensor and factors such as the molecule to be detected and the downstream experiments in which the sensor will be applied should guide the specific blueprint of the final construct. The completed sensor plasmid needs to be rigorously tested with appropriate controls to ensure that its dynamic range, signal strength, sensitivity and specificity are suitable for its intended applications. In this chapter, methods for the design, assessment and use of riboswitch sensors are provided along with those for one example application for which riboswitch sensors are ideally suited.

  1. Ammonia sensor based on QEPAS with HC-PBF as reference cell

    Science.gov (United States)

    Jiang, Meng; Feng, Qiaoling; Wang, Congying; Wei, Yufeng; Wang, Xuefeng; Liang, Tongli

    2015-08-01

    Quartz-enhanced photoacoustic spectroscopy (QEPAS) sensors involves with many desirable features, such as being small and portable, with fast continuous in situ measurements possible. In QEPAS systems, reference cells filled with gas mixtures for wavelength locking and calibration are used to improve the precision and stability of the trace gas concentration measurement. For this study, a 5 m length hollow core photonic bandgap fiber (HC-PBF) splicing with single mode fibers at two ends was manufactured as reference cell, which has long absorption path, low transmission loss and easy connectivity. Hollow cores under high pressure (3.0 × 105 Pa) were filled with a certified mixture of ammonia and nitrogen gas to reach equilibrium rapidly. The experiment results indicated that absorption spectra of reference cell with a low loss gas detection, 1.531 μm DFB laser with wavelength modulation technique was demonstrated based on QEPAS. A normalized noise equivalent absorption coefficient (NNEA) of 1.18×10-7 cm-1W/√Hz was obtained at room temperature and pressure of 760 Torr. This results in a minimum detection limit of 3.6ppm for noise equivalent concentration within a 1s lock in integration time.

  2. Cell-Based Sensor System Using L6 Cells for Broad Band Continuous Pollutant Monitoring in Aquatic Environments

    Directory of Open Access Journals (Sweden)

    Evamaria Stütz

    2012-03-01

    Full Text Available Pollution of drinking water sources represents a continuously emerging problem in global environmental protection. Novel techniques for real-time monitoring of water quality, capable of the detection of unanticipated toxic and bioactive substances, are urgently needed. In this study, the applicability of a cell-based sensor system using selected eukaryotic cell lines for the detection of aquatic pollutants is shown. Readout parameters of the cells were the acidification (metabolism, oxygen consumption (respiration and impedance (morphology of the cells. A variety of potential cytotoxic classes of substances (heavy metals, pharmaceuticals, neurotoxins, waste water was tested with monolayers of L6 cells (rat myoblasts. The cytotoxicity or cellular effects induced by inorganic ions (Ni2+ and Cu2+ can be detected with the metabolic parameters acidification and respiration down to 0.5 mg/L, whereas the detection limit for other substances like nicotine and acetaminophen are rather high, in the range of 0.1 mg/L and 100 mg/L. In a close to application model a real waste water sample shows detectable signals, indicating the existence of cytotoxic substances. The results support the paradigm change from single substance detection to the monitoring of overall toxicity.

  3. A nano-microstructured artificial-hair-cell-type sensor based on topologically graded 3D carbon nanotube bundles

    Science.gov (United States)

    Yilmazoglu, O.; Yadav, S.; Cicek, D.; Schneider, J. J.

    2016-09-01

    A design for a unique artificial-hair-cell-type sensor (AHCTS) based entirely on 3D-structured, vertically aligned carbon nanotube (CNT) bundles is introduced. Standard microfabrication techniques were used for the straightforward micro-nano integration of vertically aligned carbon nanotube arrays composed of low-layer multi-walled CNTs (two to six layers). The mechanical properties of the carbon nanotube bundles were intensively characterized with regard to various substrates and CNT morphology, e.g. bundle height. The CNT bundles display excellent flexibility and mechanical stability for lateral bending, showing high tear resistance. The integrated 3D CNT sensor can detect three-dimensional forces using the deflection or compression of a central CNT bundle which changes the contact resistance to the shorter neighboring bundles. The complete sensor system can be fabricated using a single chemical vapor deposition (CVD) process step. Moreover, sophisticated external contacts to the surroundings are not necessary for signal detection. No additional sensors or external bias for signal detection are required. This simplifies the miniaturization and the integration of these nanostructures for future microsystem set-ups. The new nanostructured sensor system exhibits an average sensitivity of 2100 ppm in the linear regime with the relative resistance change per micron (ppm μm-1) of the individual CNT bundle tip deflection. Furthermore, experiments have shown highly sensitive piezoresistive behavior with an electrical resistance decrease of up to ˜11% at 50 μm mechanical deflection. The detection sensitivity is as low as 1 μm of deflection, and thus highly comparable with the tactile hair sensors of insects, having typical thresholds on the order of 30-50 μm. The AHCTS can easily be adapted and applied as a flow, tactile or acceleration sensor as well as a vibration sensor. Potential applications of the latter might come up in artificial cochlear systems. In

  4. A nano-microstructured artificial-hair-cell-type sensor based on topologically graded 3D carbon nanotube bundles.

    Science.gov (United States)

    Yilmazoglu, O; Yadav, S; Cicek, D; Schneider, J J

    2016-09-09

    A design for a unique artificial-hair-cell-type sensor (AHCTS) based entirely on 3D-structured, vertically aligned carbon nanotube (CNT) bundles is introduced. Standard microfabrication techniques were used for the straightforward micro-nano integration of vertically aligned carbon nanotube arrays composed of low-layer multi-walled CNTs (two to six layers). The mechanical properties of the carbon nanotube bundles were intensively characterized with regard to various substrates and CNT morphology, e.g. bundle height. The CNT bundles display excellent flexibility and mechanical stability for lateral bending, showing high tear resistance. The integrated 3D CNT sensor can detect three-dimensional forces using the deflection or compression of a central CNT bundle which changes the contact resistance to the shorter neighboring bundles. The complete sensor system can be fabricated using a single chemical vapor deposition (CVD) process step. Moreover, sophisticated external contacts to the surroundings are not necessary for signal detection. No additional sensors or external bias for signal detection are required. This simplifies the miniaturization and the integration of these nanostructures for future microsystem set-ups. The new nanostructured sensor system exhibits an average sensitivity of 2100 ppm in the linear regime with the relative resistance change per micron (ppm μm(-1)) of the individual CNT bundle tip deflection. Furthermore, experiments have shown highly sensitive piezoresistive behavior with an electrical resistance decrease of up to ∼11% at 50 μm mechanical deflection. The detection sensitivity is as low as 1 μm of deflection, and thus highly comparable with the tactile hair sensors of insects, having typical thresholds on the order of 30-50 μm. The AHCTS can easily be adapted and applied as a flow, tactile or acceleration sensor as well as a vibration sensor. Potential applications of the latter might come up in artificial cochlear systems. In

  5. Nanoparticle-Based and Bioengineered Probes and Sensors to Detect Physiological and Pathological Biomarkers in Neural Cells.

    Science.gov (United States)

    Maysinger, Dusica; Ji, Jeff; Hutter, Eliza; Cooper, Elis

    2015-01-01

    Nanotechnology, a rapidly evolving field, provides simple and practical tools to investigate the nervous system in health and disease. Among these tools are nanoparticle-based probes and sensors that detect biochemical and physiological properties of neurons and glia, and generate signals proportionate to physical, chemical, and/or electrical changes in these cells. In this context, quantum dots (QDs), carbon-based structures (C-dots, grapheme, and nanodiamonds) and gold nanoparticles are the most commonly used nanostructures. They can detect and measure enzymatic activities of proteases (metalloproteinases, caspases), ions, metabolites, and other biomolecules under physiological or pathological conditions in neural cells. Here, we provide some examples of nanoparticle-based and genetically engineered probes and sensors that are used to reveal changes in protease activities and calcium ion concentrations. Although significant progress in developing these tools has been made for probing neural cells, several challenges remain. We review many common hurdles in sensor development, while highlighting certain advances. In the end, we propose some future directions and ideas for developing practical tools for neural cell investigations, based on the maxim "Measure what is measurable, and make measurable what is not so" (Galileo Galilei).

  6. Nanoparticle-based and bioengineered probes and sensors to detect physiological and pathological biomarkers in neural cells

    Directory of Open Access Journals (Sweden)

    Dusica eMaysinger

    2015-12-01

    Full Text Available Nanotechnology, a rapidly evolving field, provides simple and practical tools to investigate the nervous system in health and disease. Among these tools are nanoparticle-based probes and sensors that detect biochemical and physiological properties of neurons and glia, and generate signals proportionate to physical, chemical, and/or electrical changes in these cells. In this context, quantum dots (QDs, carbon-based structures (C-dots, graphene and nanodiamonds and gold nanoparticles are the most commonly used nanostructures. They can detect and measure enzymatic activities of proteases (metalloproteinases, caspases, ions, metabolites, and other biomolecules under physiological or pathological conditions in neural cells. Here, we provide some examples of nanoparticle-based and genetically engineered probes and sensors that are used to reveal changes in protease activities and calcium ion concentrations. Although significant progress in developing these tools has been made for probing neural cells, several challenges remain. We review many common hurdles in sensor development, while highlighting certain advances. In the end, we propose some future directions and ideas for developing practical tools for neural cell investigations, based on the maxim Measure what is measurable, and make measurable what is not so (Galileo Galilei.

  7. L-Lactate-selective microbial sensor based on flavocytochrome b2-enriched yeast cells using recombinant and nanotechnology approaches.

    Science.gov (United States)

    Karkovska, Maria; Smutok, Oleh; Stasyuk, Nataliya; Gonchar, Mykhailo

    2015-11-01

    In the recent years, nanotechnology is the most developing branch due to a wide variety of potential applications in biomedical, biotechnological and agriculture fields. The binding nanoparticles with various biological molecules makes them attractive candidates for using in sensor technologies. The particularly actual is obtaining the bionanomembranes based on biocatalytic elements with improved sensing characteristics. The aim of this investigation is to study the properties of microbial L-lactate-selective sensor based on using the recombinant Hansenula polymorpha yeast cells overproducing flavocytochrome b2 (FC b2), as well as additionally enriched by the enzyme bound with gold nanoparticles (FC b2-nAu). Although, the high permeability of the living cells to nanoparticles is being intensively studied (mostly for delivery of drugs), the idea of using both recombinant technology and nanotechnology to increase the amount of the target enzyme in the biosensing layer is really novel. The FC b2-nAu-enriched living and permeabilized yeast cells were used for construction of a bioselective membrane of microbial L-lactate-selective amperometric biosensor. Phenazine methosulphate was served as a free defusing electron transfer mediator which provides effective electron transfer from the reduced enzyme to the electrode surface. It was shown that the output to L-lactate of FC b2-nAu-enriched permeabilized yeast cells is 2.5-fold higher when compared to the control cells. The obtained results confirm that additional enrichment of the recombinant yeast cell by the enzyme bound with nanoparticles improves the analytical parameters of microbial sensor.

  8. Nanoparticle-based Sensors

    Directory of Open Access Journals (Sweden)

    V.K. Khanna

    2008-09-01

    Full Text Available Nanoparticles exhibit several unique properties that can be applied to develop chemical and biosensorspossessing desirable features like enhanced sensitivity and lower detection limits. Gold nanoparticles arecoated with sugars tailored to recognise different biological substances. When mixed with a weak solution ofthe sugar-coated nanoparticles, the target substance, e.g., ricin or E.coli, attaches to the sugar, thereby alteringits properties and changing the colour. Spores of bacterium labeled with carbon dots have been found to glowupon illumination when viewed with a confocal microscope. Enzyme/nanoparticle-based optical sensors forthe detection of organophosphate (OP compounds employ nanoparticle-modified fluorescence of an inhibitorof the enzyme to generate the signal for the OP compound detection. Nanoparticles shaped as nanoprisms,built of silver atoms, appear red on exposure to light. These nanoparticles are used as diagnostic labels thatglow when target DNA, e.g., those of anthrax or HIV, are present. Of great importance are tools like goldnanoparticle-enhanced surface-plasmon resonance sensor and silver nanoparticle surface-enhanced portableRaman integrated tunable sensor. Nanoparticle metal oxide chemiresistors using micro electro mechanical systemhotplate are very promising devices for toxic gas sensing. Chemiresistors comprising thin films of nanogoldparticles, encapsulated in monomolecular layers of functionalised alkanethiols, deposited on interdigitatedmicroelectrodes, show resistance changes through reversible absorption of vapours of harmful gases. Thispaper reviews the state-of-the-art sensors for chemical and biological terror agents, indicates their capabilitiesand applications, and presents the future scope of these devices.Defence Science Journal, 2008, 58(5, pp.608-616, DOI:http://dx.doi.org/10.14429/dsj.58.1683

  9. Model-based cell number quantification using online single-oxygen sensor data for tissue engineering perfusion bioreactors.

    Science.gov (United States)

    Lambrechts, T; Papantoniou, I; Sonnaert, M; Schrooten, J; Aerts, J-M

    2014-10-01

    Online and non-invasive quantification of critical tissue engineering (TE) construct quality attributes in TE bioreactors is indispensable for the cost-effective up-scaling and automation of cellular construct manufacturing. However, appropriate monitoring techniques for cellular constructs in bioreactors are still lacking. This study presents a generic and robust approach to determine cell number and metabolic activity of cell-based TE constructs in perfusion bioreactors based on single oxygen sensor data in dynamic perfusion conditions. A data-based mechanistic modeling technique was used that is able to correlate the number of cells within the scaffold (R(2)  = 0.80) and the metabolic activity of the cells (R(2)  = 0.82) to the dynamics of the oxygen response to step changes in the perfusion rate. This generic non-destructive measurement technique is effective for a large range of cells, from as low as 1.0 × 10(5) cells to potentially multiple millions of cells, and can open-up new possibilities for effective bioprocess monitoring.

  10. Development of cell-based quantitative evaluation method for cell cycle-arrest type cancer drugs for apoptosis by high precision surface plasmon resonance sensor

    Science.gov (United States)

    Ona, Toshihiro; Nishijima, Hiroshi; Kosaihira, Atsushi; Shibata, Junko

    2008-04-01

    In vitro rapid and quantitative cell-based assay is demanded to verify the efficacy prediction of cancer drugs since a cancer patient may have unconventional aspects of tumor development. Here, we show the rapid and non-label quantitative verifying method and instrumentation of apoptosis for cell cycle-arrest type cancer drugs (Roscovitine and D-allose) by reaction analysis of living liver cancer cells cultured on a sensor chip with a newly developed high precision (50 ndeg s -1 average fluctuation) surface plasmon resonance (SPR) sensor. The time-course cell reaction as the SPR angle change rate for 10 min from 30 min cell culture with a drug was significantly related to cell viability. By the simultaneous detection of differential SPR angle change and fluorescence by specific probes using the new instrument, the SPR angle was related to the nano-order potential decrease in inner mitochondrial membrane potential. The results obtained are universally valid for the cell cycle-arrest type cancer drugs, which mediate apoptosis through different cell-signaling pathways, by a liver cancer cell line of Hep G2 (Pcancer cells from patients in clinical use.

  11. Evaluation of therapeutic effects of natural killer (NK) cell-based immunotherapy in mice using in vivo apoptosis bioimaging with a caspase-3 sensor.

    Science.gov (United States)

    Lee, Ho Won; Singh, Thoudam Debraj; Lee, Sang-Woo; Ha, Jeoung-Hee; Rehemtulla, Alnawaz; Ahn, Byeong-Cheol; Jeon, Young Hyun; Lee, Jaetae

    2014-07-01

    Natural killer (NK) cell-based immunotherapy is a promising strategy for cancer treatment, and caspase-3 is an important effector molecule in NK cell-mediated apoptosis in cancers. Here, we evaluated the antitumor effects of NK cell-based immunotherapy by serial noninvasive imaging of apoptosis using a caspase-3 sensor in mice with human glioma xenografts. Human glioma cells expressing both a caspase-3 sensor as a surrogate marker for caspase-3 activation and Renilla luciferase (Rluc) as a surrogate marker for cell viability were established and referred to as D54-CR cells. Human NK92 cells were used as effector cells. Treatment with NK92 cells resulted in a time- and effector number-dependent increase in bioluminescence imaging (BLI) activity of the caspase-3 sensor in D54-CR cells in vitro. Caspase-3 activation by NK92 treatment was blocked by Z-VAD treatment in D54-CR cells. Transfusion of NK92 cells induced an increase of the BLI signal by caspase-3 activation in a dose- and time-dependent manner in D54-CR tumor-bearing mice but not in PBS-treated mice. Accordingly, sequential BLI with the Rluc reporter gene revealed marked retardation of tumor growth in the NK92-treatment group but not in the PBS-treatment group. These data suggest that noninvasive imaging of apoptosis with a caspase-3 sensor can be used as an effective tool for evaluation of therapeutic efficacy as well as for optimization of NK cell-based immunotherapy.-Lee, H. W., Singh, T. D., Lee, S.-W., Ha, J.-H., Rehemtulla, A., Ahn, B.-C., Jeon, Y.-H., Lee, J. Evaluation of therapeutic effects of natural killer (NK) cell-based immunotherapy in mice using in vivo apoptosis bioimaging with a caspase-3 sensor.

  12. Flexible sensors based on nanoparticles.

    Science.gov (United States)

    Segev-Bar, Meital; Haick, Hossam

    2013-10-22

    Flexible sensors can be envisioned as promising components for smart sensing applications, including consumer electronics, robotics, prosthetics, health care, safety equipment, environmental monitoring, homeland security and space flight. The current review presents a concise, although admittedly nonexhaustive, didactic review of some of the main concepts and approaches related to the use of nanoparticles (NPs) in flexible sensors. The review attempts to pull together different views and terminologies used in the NP-based sensors, mainly those established via electrical transduction approaches, including, but, not confined to: (i) strain-gauges, (ii) flexible multiparametric sensors, and (iii) sensors that are unaffected by mechanical deformation. For each category, the review presents and discusses the common fabrication approaches and state-of-the-art results. The advantages, weak points, and possible routes for future research, highlighting the challenges for NP-based flexible sensors, are presented and discussed as well.

  13. Graphene based piezoresistive pressure sensor

    NARCIS (Netherlands)

    Zhu, S.E.; Ghatkesar, M.K.; Zhang, C.; Janssen, G.C.A.M.

    2013-01-01

    We present a pressure sensor based on the piezoresistive effect of graphene. The sensor is a 100 nm thick, 280 μm wide square silicon nitride membrane with graphene meander patterns located on the maximum strain area. The multilayer, polycrystalline graphene was obtained by chemical vapor deposition

  14. A Complete Optical Sensor System Based on a POF-SPR Platform and a Thermo-Stabilized Flow Cell for Biochemical Applications.

    Science.gov (United States)

    Cennamo, Nunzio; Chiavaioli, Francesco; Trono, Cosimo; Tombelli, Sara; Giannetti, Ambra; Baldini, Francesco; Zeni, Luigi

    2016-02-04

    An optical sensor platform based on surface plasmon resonance (SPR) in a plastic optical fiber (POF) integrated into a thermo-stabilized flow cell for biochemical sensing applications is proposed. This device has been realized and experimentally tested by using a classic receptor-analyte assay. For this purpose, the gold surface of the POF was chemically modified through the formation of a self-assembling monolayer. The surface robustness of the POF-SPR platform has been tested for the first time thanks to the flow cell. The experimental results show that the proposed device can be successfully used for label-free biochemical sensing. The final goal of this work is to achieve a complete, small-size, simple to use and low cost optical sensor system. The whole system with the flow cell and the optical sensor are extensively described, together with the experimental results obtained with an immunoglobulin G (IgG)/anti-IgG assay.

  15. A Complete Optical Sensor System Based on a POF-SPR Platform and a Thermo-Stabilized Flow Cell for Biochemical Applications

    Directory of Open Access Journals (Sweden)

    Nunzio Cennamo

    2016-02-01

    Full Text Available An optical sensor platform based on surface plasmon resonance (SPR in a plastic optical fiber (POF integrated into a thermo-stabilized flow cell for biochemical sensing applications is proposed. This device has been realized and experimentally tested by using a classic receptor-analyte assay. For this purpose, the gold surface of the POF was chemically modified through the formation of a self-assembling monolayer. The surface robustness of the POF-SPR platform has been tested for the first time thanks to the flow cell. The experimental results show that the proposed device can be successfully used for label-free biochemical sensing. The final goal of this work is to achieve a complete, small-size, simple to use and low cost optical sensor system. The whole system with the flow cell and the optical sensor are extensively described, together with the experimental results obtained with an immunoglobulin G (IgG/anti-IgG assay.

  16. Position sensor based on slit imaging

    Institute of Scientific and Technical Information of China (English)

    Aijun Zeng(曾爱军); Xiangzhao Wang(王向朝); Yang Bu(步扬); Dailin Li(李代林)

    2004-01-01

    A position sensor based on slit imaging is proposed and its measurement principle is described.An imaging slit is illuminated by a collimated laser beam with square-wave modulation and imaged on a detection double slit through a 4f system.A magnified image of the detection double slit is formed on a bi-cell detector.The position of the imaging slit is obtained by detecting light intensity on two parts of the bi-cell detector.In experiments,the feasibility of the sensor was verified.The repeatability was less than 40 nm.

  17. A Portable Cell-Based Impedance Sensor for Toxicity Testing of Drinking Water

    Science.gov (United States)

    2009-05-07

    monolayer formation. Sterilized fluidic biochips, ready for cell seeding or pre-seeded with cells, are commercially available ( Agave BioSystems, Ithaca...were exposed to chemicals in serum-free MCDB-131 medium (Sigma-Aldrich, St. Louis, MO). Fig. 1 (A) Custom ECIS fluidic biochip available from Agave Bio...both the portable instrument and disposable fluidic biochips are commercially available through Agave BioSystems (www.aga- vebio.com). Some of the basic

  18. Solution-assisted ultrafast transfer of graphene-based thin films for solar cells and humidity sensors

    Science.gov (United States)

    Sun, Jiawei; Xie, Xiao; Bi, Hengchang; Jia, Haiyang; Zhu, Chongyang; Wan, Neng; Huang, Jianqiu; Nie, Meng; Li, Dan; Sun, Litao

    2017-03-01

    Vacuum filtration enables the fabrication of large-area graphene-based membranes (GBMs), possessing a smoother surface than that by spray, spin coating or drop casting. However, due to the strong interaction with substrates, the separation of thin GBMs from the filter is problematic. Conventional stamping separation/transfer of graphene oxide (GO) thin films requires another substrate and pressing for >10 h, which may damage the delicate structure of the transfer substrates. Other methods require GO to be reduced on filters before separation, thus limiting the reduction methods. Inspired by a coagulation bath that enables rapid formation of ultrastrong GO fibers, we present an ultrafast (energy of hydrogen bonds also demonstrates another reason for the successful separation. The film thickness ranges from 45 nm to several micrometers. When used as a composite of counter electrodes in dye sensitized solar cells, it showed higher (8.58%) power conversion efficiency than its spin-(7.71%) and spray-coated (8.07%) counterparts. It also showed promising performance in capacitive humidity sensors. The capacitance varied by three orders of magnitude in the range of the relative humidity of 15%–95%. Therefore the strategy realizes an ultrafast and high-quality film production which is suitable for various applications.

  19. Sensitive detection of E. Coli cells by long period gratings based optical sensor

    Science.gov (United States)

    Kaushik, Siddharth; Tiwari, Umesh; Kaur, Satinderdeep; Rajesh, Paul, A. K.; Bhatnagar, R.

    2016-04-01

    We present a novel bacterial sensing platform based on long period gratings written in photosensitive single mode optical fiber by UV eximer laser (248 nm). Shift in wavelength with varied concentrations were observed in transmission spectrum. Significant wavelength shifts were noted for all dilutions with Outer Membrane Protein Complex (OMPC) antibody immobilized LPG sensing probe. A considerable shift of 0.55938 nm in wavelength is observed when 10-5 dilution (180 CFU/ ml) of E.Coli is passed over OMPC immobilized sensing probe.

  20. Optical Fiber Grating based Sensors

    DEFF Research Database (Denmark)

    Michelsen, Susanne

    2003-01-01

    In this thesis differenct optical fiber gratings are used for sensor purposes. If a fiber with a core concentricity error (CCE) is used, a directional dependent bend sensor can be produced. The CCE direction can be determined by means of diffraction. This makes it possible to produce long......-period gratings in a fiber with a CCE direction parallel or perpendicular to the writing direction. The maximal bending sensitivity is independent on the writing direction, but the detailed bending response is different in the two cases. A temperature and strain sensor, based on a long-period grating and two...... wavelength. It is shown that it is possible to tune and modulate a DFB fiber laser with both strain from a piezoelectric transducer and by temperature through resistive heating of a methal film. Both a chemical deposited silver layer and an electron-beam evaporation technique has been investigated, to find...

  1. Selection of optimal sensors for predicting performance of polymer electrolyte membrane fuel cell

    Science.gov (United States)

    Mao, Lei; Jackson, Lisa

    2016-10-01

    In this paper, sensor selection algorithms are investigated based on a sensitivity analysis, and the capability of optimal sensors in predicting PEM fuel cell performance is also studied using test data. The fuel cell model is developed for generating the sensitivity matrix relating sensor measurements and fuel cell health parameters. From the sensitivity matrix, two sensor selection approaches, including the largest gap method, and exhaustive brute force searching technique, are applied to find the optimal sensors providing reliable predictions. Based on the results, a sensor selection approach considering both sensor sensitivity and noise resistance is proposed to find the optimal sensor set with minimum size. Furthermore, the performance of the optimal sensor set is studied to predict fuel cell performance using test data from a PEM fuel cell system. Results demonstrate that with optimal sensors, the performance of PEM fuel cell can be predicted with good quality.

  2. Radar based autonomous sensor module

    Science.gov (United States)

    Styles, Tim

    2016-10-01

    Most surveillance systems combine camera sensors with other detection sensors that trigger an alert to a human operator when an object is detected. The detection sensors typically require careful installation and configuration for each application and there is a significant burden on the operator to react to each alert by viewing camera video feeds. A demonstration system known as Sensing for Asset Protection with Integrated Electronic Networked Technology (SAPIENT) has been developed to address these issues using Autonomous Sensor Modules (ASM) and a central High Level Decision Making Module (HLDMM) that can fuse the detections from multiple sensors. This paper describes the 24 GHz radar based ASM, which provides an all-weather, low power and license exempt solution to the problem of wide area surveillance. The radar module autonomously configures itself in response to tasks provided by the HLDMM, steering the transmit beam and setting range resolution and power levels for optimum performance. The results show the detection and classification performance for pedestrians and vehicles in an area of interest, which can be modified by the HLDMM without physical adjustment. The module uses range-Doppler processing for reliable detection of moving objects and combines Radar Cross Section and micro-Doppler characteristics for object classification. Objects are classified as pedestrian or vehicle, with vehicle sub classes based on size. Detections are reported only if the object is detected in a task coverage area and it is classified as an object of interest. The system was shown in a perimeter protection scenario using multiple radar ASMs, laser scanners, thermal cameras and visible band cameras. This combination of sensors enabled the HLDMM to generate reliable alerts with improved discrimination of objects and behaviours of interest.

  3. Reputation-Based Secure Sensor Localization in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Jingsha He

    2014-01-01

    Full Text Available Location information of sensor nodes in wireless sensor networks (WSNs is very important, for it makes information that is collected and reported by the sensor nodes spatially meaningful for applications. Since most current sensor localization schemes rely on location information that is provided by beacon nodes for the regular sensor nodes to locate themselves, the accuracy of localization depends on the accuracy of location information from the beacon nodes. Therefore, the security and reliability of the beacon nodes become critical in the localization of regular sensor nodes. In this paper, we propose a reputation-based security scheme for sensor localization to improve the security and the accuracy of sensor localization in hostile or untrusted environments. In our proposed scheme, the reputation of each beacon node is evaluated based on a reputation evaluation model so that regular sensor nodes can get credible location information from highly reputable beacon nodes to accomplish localization. We also perform a set of simulation experiments to demonstrate the effectiveness of the proposed reputation-based security scheme. And our simulation results show that the proposed security scheme can enhance the security and, hence, improve the accuracy of sensor localization in hostile or untrusted environments.

  4. Bioinspired solar water splitting, sensitized solar cells, and ultraviolet sensor based on semiconductor nanocrystal antenna/graphene nanoassemblies

    Science.gov (United States)

    Chang, Haixin; Lv, Xiaojun; Zheng, Zijian; Wu, Hongkai

    2012-02-01

    Graphene, two-dimensional carbon crystal with only one atom thickness, provides a general platform for nanoscale even atomic scale optoelectronics and photonics. Graphene has many advantages for optoelectronics such as high conductivity, high electronic mobility, flexibility and transparency. However, graphene also has disadvantages such as low light absorption which are unfavorable for optoelectronic devices. On the other hand, many natural photonic systems provide wonderful solution to enhance light absorption for solar energy harvesting and conversion, such as chlorophyll in green plants. Herein, learning from nature, we described bioinspired photocatalytic solar-driven water splitting, sensitized solar cells and ultraviolet optoelectronic sensors enabled by introducing photosensitive semiconductor nanocrystal antenna to graphene for constructing a series of graphene/nanocrystal nanoassemblies. We have demonstrated that high performance optoelectronic devices can come true with the introducing of photosensitive nanocrystal antenna elements.

  5. Cell Permeable Ratiometric Fluorescent Sensors for Imaging Phosphoinositides.

    Science.gov (United States)

    Mondal, Samsuzzoha; Rakshit, Ananya; Pal, Suranjana; Datta, Ankona

    2016-07-15

    Phosphoinositides are critical cell-signal mediators present on the plasma membrane. The dynamic change of phosphoinositide concentrations on the membrane including clustering and declustering mediates signal transduction. The importance of phosphoinositides is scored by the fact that they participate in almost all cell-signaling events, and a defect in phosphoinositide metabolism is linked to multiple diseases including cancer, bipolar disorder, and type-2 diabetes. Optical sensors for visualizing phosphoinositide distribution can provide information on phosphoinositide dynamics. This exercise will ultimately afford a handle into understanding and manipulating cell-signaling processes. The major requirement in phosphoinositide sensor development is a selective, cell permeable probe that can quantify phosphoinositides. To address this requirement, we have developed short peptide-based ratiometric fluorescent sensors for imaging phosphoinositides. The sensors afford a selective response toward two crucial signaling phosphoinositides, phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol-4-phosphate (PI4P), over other anionic membrane phospholipids and soluble inositol phosphates. Dissociation constant values indicate up to 4 times higher probe affinity toward PI(4,5)P2 when compared to PI4P. Significantly, the sensors are readily cell-permeable and enter cells within 15 min of incubation as indicated by multiphoton excitation confocal microscopy. Furthermore, the sensors light up signaling phosphoinositides present both on the cell membrane and on organelle membranes near the perinuclear space, opening avenues for quantifying and monitoring phosphoinositide signaling.

  6. Room-temperature Surface Modification of Cu nanowires and Their Applications in Transparent Electrodes, SERS-based Sensors and Organic Solar Cells.

    Science.gov (United States)

    Wang, Xiao; Wang, Ranran; Zhai, Haitao; Shen, Xi; Wang, Tao; Shi, Liangjing; Yu, Richeng; Sun, Jing

    2016-10-05

    Cu nanowires (Copper nanowires) have attracted lots of attention recently due to their potential applications in transparent electrodes, SERS sensors and solar cells. However, as the surface composition and morphology of Cu nanowires severely influence the performance of the devices based on them, facial surface modification methods need to be developed. Herein, we propose a room-temperature, time-saving aqueous solution method, which can simultaneously clean the surface of copper nanowires and decorate them with Ag nanoparticles at room temperature without any atmospheric control. The unique "sesame-candy-bar" structure brought about significant enhancement on the electrical, optical and mechanical performances of Cu nanowire networks. Transparent electrodes with ideal opto-electrical performance (47  sq-1 @ 89.1 % T) and high anti-oxidation, anti-thermal and electrical stability were fabricated. Stretchable electrodes based on the modified Cu nanowire networks showed superior stretch ability and cycling stability. SERS sensors and organic solar cells constructed based on Cu nanowire networks exhibited higher performance due to the enhanced surface plasmonic coupling and light scattering effect. We believe that the method will shed light on the large-scale fabrication and application of Cu nanowire based devices.

  7. Simple and rapid fabrication of disposable carbon-based electrochemical cells using an electronic craft cutter for sensor and biosensor applications.

    Science.gov (United States)

    Afonso, André S; Uliana, Carolina V; Martucci, Diego H; Faria, Ronaldo C

    2016-01-01

    This work describes the construction of an all-plastic disposable carbon-based electrochemical cell (DCell) using a simple procedure based on the use of a home cutter printer for prototyping and laminating. The cutter printer and adhesive vinyl films were used to produce three electrodes in an electrochemical cell layout, and a laminating process was then used to define the geometric area and insulate the electrodes. The DCell showed excellent performance in several applications including the determination of toxic metals in water samples, the immobilization of DNA and the detection of Salmonella. An unmodified DCell was applied for Pb and Cd detection in the range of 100-300 ng mL(-1) with a limit of detection of 50 and 39 ng mL(-1) for Cd and Pb, respectively. DNA was successfully immobilized on a DCell and used for studies of interaction between bisphenol A and DNA. The square wave voltammetry of a DNA modified DCell presented a guanine oxidation current 2.5 times greater after exposure of the electrode to bisphenol A and no current variation for the adenine moiety indicating that bisphenol A showed a preference for DNA interaction sites. A magneto-immunoassay was developed using a DCell for Salmonella detection in milk samples. The system presented a linear range from 100 to 700 cells mL(-1) with a limit of detection of 100 cells mL(-1) and good recovery values between 93% and 101% in milk samples, with no interference from Escherichia coli. Using the proposed method, hundreds of DCells can be assembled in less than two hours, at a material cost of less than US $0.02 per cell. The all-plastic disposable electrochemical cell developed was successfully applied as an electrochemical sensor and biosensor. The feasibility of the developed all-plastic disposable electrochemical cell was demonstrated in applications as both sensor and biosensor.

  8. Sensor management based on fisher information gain

    Institute of Scientific and Technical Information of China (English)

    Tian Kangsheng; Zhu Guangxi

    2006-01-01

    Multi-sensor system is becoming increasingly important in a variety of military and civilian applications. In general, single sensor system can only provide partial information about environment while multi-sensor system provides a synergistic effect, which improves the quality and availability of information. Data fusion techniques can effectively combine this environmental information from similar and/or dissimilar sensors. Sensor management, aiming at improving data fusion performance by controlling sensor behavior, plays an important role in a data fusion process. This paper presents a method using fisher information gain based sensor effectiveness metric for sensor assignment in multi-sensor and multi-target tracking applications. The fisher information gain is computed for every sensor-target pairing on each scan. The advantage for this metric over other ones is that the fisher information gain for the target obtained by multi-sensors is equal to the sum of ones obtained by the individual sensor, so standard transportation problem formulation can be used to solve this problem without importing the concept of pseudo sensor. The simulation results show the effectiveness of the method.

  9. Wireless SAW Based Temperature Gradient Sensor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Prime Photonics proposes design and development of a surface acoustic wave (SAW) based temperature gradient sensor for instrumentation of thermal protection systems...

  10. Optical Oxygen Sensors for Applications in Microfluidic Cell Culture

    Directory of Open Access Journals (Sweden)

    Samantha M. Grist

    2010-10-01

    Full Text Available The presence and concentration of oxygen in biological systems has a large impact on the behavior and viability of many types of cells, including the differentiation of stem cells or the growth of tumor cells. As a result, the integration of oxygen sensors within cell culture environments presents a powerful tool for quantifying the effects of oxygen concentrations on cell behavior, cell viability, and drug effectiveness. Because microfluidic cell culture environments are a promising alternative to traditional cell culture platforms, there is recent interest in integrating oxygen-sensing mechanisms with microfluidics for cell culture applications. Optical, luminescence-based oxygen sensors, in particular, show great promise in their ability to be integrated with microfluidics and cell culture systems. These sensors can be highly sensitive and do not consume oxygen or generate toxic byproducts in their sensing process. This paper presents a review of previously proposed optical oxygen sensor types, materials and formats most applicable to microfluidic cell culture, and analyzes their suitability for this and other in vitro applications.

  11. Enhancing the response of microbial fuel cell based toxicity sensors to Cu(II) with the applying of flow-through electrodes and controlled anode potentials.

    Science.gov (United States)

    Jiang, Yong; Liang, Peng; Zhang, Changyong; Bian, Yanhong; Yang, Xufei; Huang, Xia; Girguis, Peter R

    2015-08-01

    The application of microbial fuel cell (MFC)-based toxicity sensors to real-world water monitoring is partly impeded by the limited sensitivity. To address this limitation, this study optimized the flow configurations and the control modes. Results revealed that the sensitivity increased by ∼15-41times with the applying of a flow-through anode, compared to those with a flow-by anode. The sensors operated in the controlled anode potential (CP) mode delivered better sensitivity than those operated in the constant external resistance (ER) mode over a broad range of anode potentials from -0.41V to +0.1V. Electrodeposition of Cu(II) was found to bias the toxicity measurement at low anode potentials. The optimal anode potential was approximately -0.15V, at which the sensor achieved an unbiased measurement of toxicity and the highest sensitivity. This value was greater than those required for electrodeposition while smaller than those for power overshoot.

  12. DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity.

    Science.gov (United States)

    Liu, Yang; Blanchfield, Lori; Ma, Victor Pui-Yan; Andargachew, Rakieb; Galior, Kornelia; Liu, Zheng; Evavold, Brian; Salaita, Khalid

    2016-05-17

    T cells are triggered when the T-cell receptor (TCR) encounters its antigenic ligand, the peptide-major histocompatibility complex (pMHC), on the surface of antigen presenting cells (APCs). Because T cells are highly migratory and antigen recognition occurs at an intermembrane junction where the T cell physically contacts the APC, there are long-standing questions of whether T cells transmit defined forces to their TCR complex and whether chemomechanical coupling influences immune function. Here we develop DNA-based gold nanoparticle tension sensors to provide, to our knowledge, the first pN tension maps of individual TCR-pMHC complexes during T-cell activation. We show that naïve T cells harness cytoskeletal coupling to transmit 12-19 pN of force to their TCRs within seconds of ligand binding and preceding initial calcium signaling. CD8 coreceptor binding and lymphocyte-specific kinase signaling are required for antigen-mediated cell spreading and force generation. Lymphocyte function-associated antigen 1 (LFA-1) mediated adhesion modulates TCR-pMHC tension by intensifying its magnitude to values >19 pN and spatially reorganizes the location of TCR forces to the kinapse, the zone located at the trailing edge of migrating T cells, thus demonstrating chemomechanical crosstalk between TCR and LFA-1 receptor signaling. Finally, T cells display a dampened and poorly specific response to antigen agonists when TCR forces are chemically abolished or physically "filtered" to a level below ∼12 pN using mechanically labile DNA tethers. Therefore, we conclude that T cells tune TCR mechanics with pN resolution to create a checkpoint of agonist quality necessary for specific immune response.

  13. Relational-Based Sensor Data Cleansing

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem; Liu, Xiufeng; Nordbjerg, Finn Ebertsen

    2015-01-01

    Today sensors are widely used in many monitoring applications. Due to some random environmental effects and/or sensing failures, the collected sensor data is typically noisy. Thus, it is critical to cleanse the sensor data before using it to answer queries or conduct data analysis. Popular data...... cleansing approaches, such as classification, prediction and moving average are not suited for embedded sensor devices, due to the limited storage and processing capabilities. In this paper, we propose a sensor data cleansing approach using the relational-based technologies, including constraints, triggers...

  14. Development of sensors for hydrogen safety on fuel cell vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Kitanoya, S.; Furusaki, K.; Inoue, R.; Watanabe, M.; Matsuno, T.; Ichikawa, D. [NGK Spark Plug Co. Ltd, Aichi (Japan)

    2007-07-01

    When combusted, hydrogen fuel used in fuel cell vehicles (FCV) generates water only. Although this technology can help protect against global warming, the safety of hydrogen fuel must be resolved before widespread use of hydrogen-based FCVs can be realized. Hydrogen gas has a broad flammability range and will ignite when mixed with air in the ranges from 4 to 75 per cent. The primary technical requirement for FCV safety is to detect hydrogen leaks and shut off the hydrogen gas. Hydrogen sensors that detect hydrogen leaks are an important part of the safety issue. This paper presented 2 newly developed hydrogen sensors in which micro-electromechanical system (MEMS) technology was used to build a micro-heater with very small heat capacity. Both sensors have different detection principles. One is placed above the hydrogen tank and fuel cells. This combustion type sensor uses catalytic combustion of the hydrogen on the micro-heater. It features quick start-up and high accuracy. The other type of hydrogen sensor can be place in a hydrogen gas purging pipe. This thermal conduction-type sensor can detect the change in thermal conductivity of the gas. The catalytic combustion sensor is based on the detection of the voltage difference between the detection heater and reference heater. 6 refs., 3 tabs., 24 figs.

  15. Nanotube-Based Chemical and Biomolecular Sensors

    Institute of Scientific and Technical Information of China (English)

    J.Koh; B.Kim; S.Hong; H.Lim; H.C.Choi

    2008-01-01

    We present a brief review about recent results regarding carbon nanotube (CNT)-based chemical and biomolecular sensors. For the fabrication of CNT-based sensors, devices containing CNT channels between two metal electrodes are first fabricated usually via chemical vapor deposition (CVD) process or "surface programmed assembly" method. Then, the CNT surfaces are often functionalized to enhance the selectivity of the sensors. Using this process, highly-sensitive CNT-based sensors can be fabricated for the selective detection of various chemical and biological molecules such as hydrogen, ammonia, carbon monoxide, chlorine gas, DNA, glucose, alcohol, and proteins.

  16. Low-power laser-based carbon monoxide sensor for fire and post-fire detection using a compact Herriott multipass cell

    Science.gov (United States)

    Thomazy, David; So, Stephen; Kosterev, Anatoliy; Lewicki, Rafal; Dong, Lei; Sani, Ardalan A.; Tittel, Frank K.

    2010-01-01

    With the anticipated retirement of Space Shuttles in the next few years, the re-supplying of short-lifetime sensors on the International Space Station (ISS) will be logistically more difficult. Carbon Monoxide (CO) is a well-known combustion product and its absence in a fire and post-fire environment is a reliable indicator for mission specialists that the air quality is at a safe to breathe level. We report on the development and performance of a prototype compact CO sensor, based on the PHOTONS platform [1], developed for the ISS based on tunable diode laser absorption spectroscopy (TDLAS). A CO absorption line at ~4285 cm-1 is targeted using a distributed-feedback (DFB) laser diode operating at room temperature. A custom designed Herriott multipass cell 16cm long, with an effective path length of 3.7 m is employed. Mechanical, optical and electronics systems are integrated into a compact package of dimensions measuring 12.4"x 3.4"x 5". Power consumption is less than 1 W, enabling prolonged battery life. A detection limit of 3 ppm is achieved when performing 40 second long temperature scans. A recent initial test at NASA-JSC was successful. Future improvements include the reduction of the sampling volume, scan time and an improved CO minimum detection limit.

  17. Measuring intracellular redox conditions using GFP-based sensors

    DEFF Research Database (Denmark)

    Björnberg, Olof; Ostergaard, Henrik; Winther, Jakob R

    2006-01-01

    Recent years have seen the development of methods for analyzing the redox conditions in specific compartments in living cells. These methods are based on genetically encoded sensors comprising variants of Green Fluorescent Protein in which vicinal cysteine residues have been introduced at solvent......-exposed positions. Several mutant forms have been identified in which formation of a disulfide bond between these cysteine residues results in changes of their fluorescence properties. The redox sensors have been characterized biochemically and found to behave differently, both spectroscopically and in terms...... of redox properties. As genetically encoded sensors they can be expressed in living cells and used for analysis of intracellular redox conditions; however, which parameters are measured depends on how the sensors interact with various cellular redox components. Results of both biochemical and cell...

  18. Relational-Based Sensor Data Cleansing

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem; Nordbjerg, Finn Ebertsen

    2015-01-01

    Today sensors are widely used in many monitoring applications. Due to some random environmental effects and/or sensing failures, the collected sensor data is typically noisy. Thus, it is critical to cleanse the data before using it for answering queries or for data analysis. Popular data cleansing...... approaches, such as classification, prediction and moving average, are not suited for embedded sensor devices, due to their limit storage and processing capabilities. In this paper, we propose a sensor data cleansing approach using the relational-based technologies, including constraints, triggers...

  19. Polypyrrole based gas sensor for ammonia detection

    Science.gov (United States)

    Dunst, K. J.; Cysewska, K.; Kalinowski, P.; Jasiński, P.

    2016-01-01

    The nature of polypyrrole response to toxic gases does not allow using the sensor in a conventional way. The main aim of this study is to acquire the information about the concentration using different approaches: a linear approximation, a non-linear approximation and a tangent method. In this paper a two-steps procedure for sensor response measurements has been utilized. Polypyrrole films were electrochemically synthesized on the interdigitated electrodes. Gas sensing measurements of polypyrrole based sensor were carried out at room temperature. The influence of the flow rate on the sensing performance to NH3 were investigated. The preliminary studies of aging of the sensor were also explored.

  20. Review of graphene-based strain sensors

    Institute of Scientific and Technical Information of China (English)

    Zhao Jing; Zhang Guang-Yu; Shi Dong-Xia

    2013-01-01

    In this paper,we review various types of graphene-based strain sensors.Graphene is a monolayer of carbon atoms,which exhibits prominent electrical and mechanical properties and can be a good candidate in compact strain sensor applications.However,a perfect graphene is robust and has a low piezoresistive sensitivity.So scientists have been driven to increase the sensitivity using different kinds of methods since the first graphene-based strain sensor was reported.We give a comprehensive review of graphene-based strain sensors with different structures and mechanisms.It is obvious that graphene offers some advantages and has potential for the strain sensor application in the near future.

  1. Integrated Temperature Sensors based on Heat Diffusion

    NARCIS (Netherlands)

    Van Vroonhoven, C.P.L.

    2015-01-01

    This thesis describes the theory, design and implementation of a new class of integrated temperature sensors, based on heat diffusion. In such sensors, temperature is sensed by measuring the time it takes for heat to diffuse through silicon. An on-chip thermal delay can be determined by geometry and

  2. SU-8 Based Piezoresistive Mechanical Sensor

    DEFF Research Database (Denmark)

    Thaysen, Jacob; Yalcinkaya, Arda Deniz; Vestergaard, R.K.

    2002-01-01

    We present the first SU-8 based piezoresistive mechanical sensor. Conventionally, silicon has been used as a piezoresistive material due to its high gauge factor and thereby high sensitivity to strain changes in a sensor. By using the fact that SU-8 is much softer than silicon and that a gold...

  3. Recent Advances in Paper-Based Sensors

    Directory of Open Access Journals (Sweden)

    Edith Chow

    2012-08-01

    Full Text Available Paper-based sensors are a new alternative technology for fabricating simple, low-cost, portable and disposable analytical devices for many application areas including clinical diagnosis, food quality control and environmental monitoring. The unique properties of paper which allow passive liquid transport and compatibility with chemicals/biochemicals are the main advantages of using paper as a sensing platform. Depending on the main goal to be achieved in paper-based sensors, the fabrication methods and the analysis techniques can be tuned to fulfill the needs of the end-user. Current paper-based sensors are focused on microfluidic delivery of solution to the detection site whereas more advanced designs involve complex 3-D geometries based on the same microfluidic principles. Although paper-based sensors are very promising, they still suffer from certain limitations such as accuracy and sensitivity. However, it is anticipated that in the future, with advances in fabrication and analytical techniques, that there will be more new and innovative developments in paper-based sensors. These sensors could better meet the current objectives of a viable low-cost and portable device in addition to offering high sensitivity and selectivity, and multiple analyte discrimination. This paper is a review of recent advances in paper-based sensors and covers the following topics: existing fabrication techniques, analytical methods and application areas. Finally, the present challenges and future outlooks are discussed.

  4. Information-based self-organization of sensor nodes of a sensor network

    Science.gov (United States)

    Ko, Teresa H.; Berry, Nina M.

    2011-09-20

    A sensor node detects a plurality of information-based events. The sensor node determines whether at least one other sensor node is an information neighbor of the sensor node based on at least a portion of the plurality of information-based events. The information neighbor has an overlapping field of view with the sensor node. The sensor node sends at least one communication to the at least one other sensor node that is an information neighbor of the sensor node in response to at least one information-based event of the plurality of information-based events.

  5. Refractometric sensor based on silicon photonic wires

    OpenAIRE

    2009-01-01

    We have characterized the refractive index sensing properties of a compact refractometric sensor based on a grated silicon photonic wire. A resolution of $10^{-5}$ in refractive index has been measured.

  6. Atmospheric corrosion sensor based on strain measurement

    Science.gov (United States)

    Kasai, Naoya; Hiroki, Masatoshi; Yamada, Toshirou; Kihira, Hiroshi; Matsuoka, Kazumi; Kuriyama, Yukihisa; Okazaki, Shinji

    2017-01-01

    In this paper, an in situ atmospheric corrosion sensor based on strain measurement is discussed. The theoretical background for measuring the reduction in thickness of low carbon steel is also presented. Based on the theoretical considerations, a test piece and apparatus for an atmospheric corrosion sensor were designed. Furthermore, in a dry–wet cyclic accelerated exposure experiment, the measured strain indicated thinning of the test piece, although the corrosion product generated on the surface of the test piece affected the results. The atmospheric corrosion sensor would be effective for evaluating atmospheric corrosion of many types of infrastructure.

  7. Nanowire-based gas sensors

    NARCIS (Netherlands)

    Chen, X.; Wong, C.K.Y.; Yuan, C.A.; Zhang, G.

    2013-01-01

    Gas sensors fabricated with nanowires as the detecting elements are powerful due to their many improved characteristics such as high surface-to-volume ratios, ultrasensitivity, higher selectivity, low power consumption, and fast response. This paper gives an overview on the recent process of the dev

  8. Soil moisture sensors based on metamaterials

    Directory of Open Access Journals (Sweden)

    Goran Kitić

    2012-12-01

    Full Text Available In this paper novel miniature metamaterial-based soil moisture sensors are presented. The sensors are based on resonant-type metamaterials and employ split-ring resonators (SRR, spiral resonators and fractal SRRs to achieve small dimensions, high sensitivity, and compatibility with standard planar fabrication technologies. All these features make the proposedsensors suitable for deployment in agriculture for precise mapping of soil humidity.

  9. Toward Sensor-Based Context Aware Systems

    Directory of Open Access Journals (Sweden)

    Kouhei Takada

    2012-01-01

    Full Text Available This paper proposes a methodology for sensor data interpretation that can combine sensor outputs with contexts represented as sets of annotated business rules. Sensor readings are interpreted to generate events labeled with the appropriate type and level of uncertainty. Then, the appropriate context is selected. Reconciliation of different uncertainty types is achieved by a simple technique that moves uncertainty from events to business rules by generating combs of standard Boolean predicates. Finally, context rules are evaluated together with the events to take a decision. The feasibility of our idea is demonstrated via a case study where a context-reasoning engine has been connected to simulated heartbeat sensors using prerecorded experimental data. We use sensor outputs to identify the proper context of operation of a system and trigger decision-making based on context information.

  10. Bulk disk resonator based ultrasensitive mass sensor

    DEFF Research Database (Denmark)

    Cagliani, Alberto; Davis, Zachary James

    2009-01-01

    In the framework of developing an innovative label-free sensor for multiarrayed biodetection applications, we present a novel bulk resonator based mass sensor. The sensor is a polysilicon disk which shows a Q-factor of 6400 in air at 68.8 MHz, resulting in mass resolutions down in the femtogram...... range. The sensor has been characterized in terms of sensitivity both for distributed mass detection, performing six consecutive depositions of e-beam evaporated Au, and localized mass detection, depositing approximately 7.5 pg of Pt/Ga/C three times consecutively with a Focused Ion Beam system....... The sensor has an extremely high distributed mass to frequency shift sensitivity of 60104 Hzcm2/¿g and shows a localized mass to frequency sensitivity up to 4405 Hz/pg with a localized mass resolution down to 15 fg. The device has been fabricated with a new microfabrication process that uses only two...

  11. LPG based all plastic pressure sensor

    DEFF Research Database (Denmark)

    Bundalo, Ivan-Lazar; Lwin, R.; Leon-Saval, S.

    2015-01-01

    A prototype all-plastic pressure sensor is presented and characterized for potential use as an endoscope. The sensor is based on Long Period Gratings (LPG) inscribed with a CO2 laser in 6-ring microstructured PMMA fiber. Through a latex coated, plastic 3D-printed transducer pod, external pressure...... is converted to longitudinal elongation of the pod and therefore of the fiber containing the LPG. The sensor has been characterised for pressures of up to 160 mBar in an in-house built pressure chamber. Furthermore, the influence of the fiber prestrain, fiber thickness and the effect of different glues...... on the sensors' responsivity have been investigated in an attempt to optimize parameters. The prototype sensor LPG peak showed a sensitivity of up to 10 pm/mBar, but our analysis shows that this can be increased significantly with further optimization....

  12. CMOS cell sensors for point-of-care diagnostics.

    Science.gov (United States)

    Adiguzel, Yekbun; Kulah, Haluk

    2012-01-01

    The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions. From this perspective, point-of-care diagnostics is a demanded field in clinics. It is also necessary both for prompt diagnosis and for providing health services evenly throughout the population, including the rural districts. The requirements can only be fulfilled by technologies whose productivity has already been proven, such as complementary metal-oxide-semiconductors (CMOS). CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities. Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature. CMOS-based sensors for cell studies have the potential to become essential counterparts of point-of-care diagnostics technologies. Hence, this review attempts to inform on the sensors fabricated with CMOS technology for point-of-care diagnostic studies, with a focus on CMOS image sensors and capacitance sensors for cell studies.

  13. CMOS Cell Sensors for Point-of-Care Diagnostics

    Directory of Open Access Journals (Sweden)

    Haluk Kulah

    2012-07-01

    Full Text Available The burden of health-care related services in a global era with continuously increasing population and inefficient dissipation of the resources requires effective solutions. From this perspective, point-of-care diagnostics is a demanded field in clinics. It is also necessary both for prompt diagnosis and for providing health services evenly throughout the population, including the rural districts. The requirements can only be fulfilled by technologies whose productivity has already been proven, such as complementary metal-oxide-semiconductors (CMOS. CMOS-based products can enable clinical tests in a fast, simple, safe, and reliable manner, with improved sensitivities. Portability due to diminished sensor dimensions and compactness of the test set-ups, along with low sample and power consumption, is another vital feature. CMOS-based sensors for cell studies have the potential to become essential counterparts of point-of-care diagnostics technologies. Hence, this review attempts to inform on the sensors fabricated with CMOS technology for point-of-care diagnostic studies, with a focus on CMOS image sensors and capacitance sensors for cell studies.

  14. A Fluorimetric Sensor for Detection of One Living Cell

    Directory of Open Access Journals (Sweden)

    Rene Kizek

    2007-03-01

    Full Text Available Nowadays, studies of metabolic pathways and processes in living organisms cannot be easily done at the cellular level. That is why the development of a new analytical methods and approaches is needed, to allow detection of different biologically important species at very low concentrations levels and sample volumes, especially in individual cells. In the present work, we suggested a sensor to detect units of living cells by means determination of plant esterases (PE based on fluorimetric detection of the products of the enzymatic hydrolysis of fluorescein diacetate in plant cell cultures (BY-2 tobacco cells and early somatic embryos of Norway spruce, clone 2/32. We standardized the sensor using a readily available esterase from pig liver. The detection limits were approximately 17 to 50 amol in 2 ml (8.5 to 25 femtomolar concentrations of esterases of the enzyme contained in BY-2 tobacco cells and spruce early somatic embryos, respectively, after re-computation on the amounts of pig liver esterases. We assumed that the optimised sensor for the determination of PE in cell extracts accomplishes all requirements for a sensitive analysis which could be usable for single cell analysis. The detection limit was 1.5 in case of analysing BY-2 tobacco cells and 0.5 in early somatic embryos. Moreover, we were able to detect single protoplasts.

  15. Gas Sensors Based on Electrodeposited Polymers

    Directory of Open Access Journals (Sweden)

    Boris Lakard

    2015-07-01

    Full Text Available Electrochemically deposited polymers, also called “synthetic metals”, have emerged as potential candidates for chemical sensing due to their interesting and tunable chemical, electrical, and structural properties. In particular, most of these polymers (including polypyrrole, polyaniline, polythiophene and their derivatives can be used as the sensitive layer of conductimetric gas sensors because of their conducting properties. An important advantage of polymer-based gas sensors is their efficiency at room temperature. This characteristic is interesting since most of the commercially-available sensors, usually based on metal oxides, work at high temperatures (300–400 °C. Consequently, polymer-based gas sensors are playing a growing role in the improvement of public health and environment control because they can lead to gas sensors operating with rapid detection, high sensitivity, small size, and specificity in atmospheric conditions. In this review, the recent advances in electrodeposited polymer-based gas sensors are summarized and discussed. It is shown that the sensing characteristics of electrodeposited polymers can be improved by chemical functionalization, nanostructuration, or mixing with other functional materials to form composites or hybrid materials.

  16. A Raspberry Pi-Based Attitude Sensor

    Science.gov (United States)

    Sreejith, A. G.; Mathew, Joice; Sarpotdar, Mayuresh; Mohan, Rekhesh; Nayak, Akshata; Safonova, Margarita; Murthy, Jayant

    We have developed a lightweight low-cost attitude sensor, based on a Raspberry Pi, built with readily available commercial components. It can be used in experiments where weight and power are constrained, such as in high-altitude lightweight balloon flights. This attitude sensor will be used as a major building block in a closed-loop control system with driver motors to stabilize and point cameras and telescopes for astronomical observations from a balloon-borne payload.

  17. A Raspberry Pi-Based Attitude Sensor

    CERN Document Server

    Sreejith, A G; Sarpotdar, Mayuresh; Mohan, Rekhesh; Nayak, Akshata; Safonova, Margarita; Murthy, Jayant

    2014-01-01

    We have developed a lightweight low-cost attitude sensor, based on a Raspberry Pi, built with readily available commercial components. It can be used in experiments where weight and power are constrained, such as in high- altitude lightweight balloon flights. This attitude sensor will be used as a major building block in a closed-loop control system with driver motors to stabilize and point cameras and telescopes for astronomical observations from a balloon-borne payload.

  18. A Path-Based Approach for Data Aggregation in Grid-Based Wireless Sensor Networks

    Institute of Scientific and Technical Information of China (English)

    Neng-Chung Wang; Yung-Kuei Chiang; Chih-Hung Hsieh

    2014-01-01

    Sensor nodes in a wireless sensor network (WSN) are typically powered by batteries, thus the energy is constrained. It is our design goal to efficiently utilize the energy of each sensor node to extend its lifetime, so as to prolong the lifetime of the whole WSN. In this paper, we propose a path-based data aggregation scheme (PBDAS) for grid-based wireless sensor networks. In order to extend the lifetime of a WSN, we construct a grid infrastructure by partitioning the whole sensor field into a grid of cells. Each cell has a head responsible for aggregating its own data with the data sensed by the others in the same cell and then transmitting out. In order to efficiently and rapidly transmit the data to the base station (BS), we link each cell head to form a chain. Each cell head on the chain takes turn becoming the chain leader responsible for transmitting data to the BS. Aggregated data moves from head to head along the chain, and finally the chain leader transmits to the BS. In PBDAS, only the cell heads need to transmit data toward the BS. Therefore, the data transmissions to the BS substantially decrease. Besides, the cell heads and chain leader are designated in turn according to the energy level so that the energy depletion of nodes is evenly distributed. Simulation results show that the proposed PBDAS extends the lifetime of sensor nodes, so as to make the lifetime of the whole network longer.

  19. Piezoresistive Chemical Sensors Based on Functionalized Hydrogels

    Directory of Open Access Journals (Sweden)

    Margarita Guenther

    2014-06-01

    Full Text Available Thin films of analyte-specific hydrogels were combined with microfabricated piezoresistive pressure transducers to obtain chemomechanical sensors that can serve as selective biochemical sensors for a continuous monitoring of metabolites. The gel swelling pressure has been monitored in simulated physiological solutions by means of the output signal of piezoresistive sensors. The interference by fructose, human serum albumin, pH, and ionic concentration on glucose sensing was studied. With the help of a database containing the calibration curves of the hydrogel-based sensors at different values of pH and ionic strength, the corrected values of pH and glucose concentration were determined using a novel calibration algorithm.

  20. Pristine carbon nanotubes based resistive temperature sensor

    Science.gov (United States)

    Alam, Md Bayazeed; Saini, Sudhir Kumar; Sharma, Daya Shankar; Agarwal, Pankaj B.

    2016-04-01

    A good sensor must be highly sensitive, faster in response, of low cost cum easily producible, and highly reliable. Incorporation of nano-dimensional particles/ wires makes conventional sensors more effective in terms of fulfilling the above requirements. For example, Carbon Nanotubes (CNTs) are promising sensing element because of its large aspect ratio, unique electronic and thermal properties. In addition to their use for widely reported chemical sensing, it has also been explored for temperature sensing. This paper presents the fabrication of CNTs based temperature sensor, prepared on silicon substrate using low cost spray coating method, which is reliable and reproducible method to prepare uniform CNTs thin films on any substrate. Besides this, simple and inexpensive method of preparation of dispersion of single walled CNTs (SWNTs) in 1,2 dichlorobenzene by using probe type ultrasonicator for debundling the CNTs for improving sensor response were used. The electrical contacts over the dispersed SWNTs were taken using silver paste electrodes. Fabricated sensors clearly show immediate change in resistance as a response to change in temperature of SWNTs. The measured sensitivity (change in resistance with temperature) of the sensor was found ˜ 0.29%/°C in the 25°C to 60°C temperature range.

  1. Wearable tactile sensor based on flexible microfluidics.

    Science.gov (United States)

    Yeo, Joo Chuan; Yu, Jiahao; Koh, Zhao Ming; Wang, Zhiping; Lim, Chwee Teck

    2016-08-16

    In this work, we develop a liquid-based thin film microfluidic tactile sensor of high flexibility, robustness and sensitivity. The microfluidic elastomeric structure comprises a pressure sensitive region and parallel arcs that interface with screen-printed electrodes. The microfluidic sensor is functionalized with a highly conductive metallic liquid, eutectic gallium indium (eGaIn). Microdeformation on the pressure sensor results in fluid displacement which corresponds to a change in electrical resistance. By emulating parallel electrical circuitry in our microchannel design, we reduced the overall electrical resistance of the sensor, therefore enhancing its device sensitivity. Correspondingly, we report a device workable within a range of 4 to 100 kPa and sensitivity of up to 0.05 kPa(-1). We further demonstrate its robustness in withstanding >2500 repeated loading and unloading cycles. Finally, as a proof of concept, we demonstrate that the sensors may be multiplexed to detect forces at multiple regions of the hand. In particular, our sensors registered unique electronic signatures in object grasping, which could provide better assessment of finger dexterity.

  2. An SPR based sensor for allergens detection.

    Science.gov (United States)

    Ashley, J; Piekarska, M; Segers, C; Trinh, L; Rodgers, T; Willey, R; Tothill, I E

    2017-02-15

    A simple, sensitive and label-free optical sensor method was developed for allergens analysis using α-casein as the biomarker for cow's milk detection, to be used directly in final rinse samples of cleaning in place systems (CIP) of food manufacturers. A Surface Plasmon Resonance (SPR) sensor chip consisting of four sensing arrays enabling the measurement of samples and control binding events simultaneously on the sensor surface was employed in this work. SPR offers several advantages in terms of label free detection, real time measurements and superior sensitivity when compared to ELISA based techniques. The gold sensor chip was used to immobilise α-casein-polyclonal antibody using EDC/NHS coupling procedure. The performance of the assay and the sensor was first optimised and characterised in pure buffer conditions giving a detection limit of 58ngmL(-1) as a direct binding assay. The assay sensitivity can be further improved by using sandwich assay format and amplified with nanoparticles. However, at this stage this is not required as the detection limit achieved exceeded the required allergens detection levels of 2µgmL(-1) for α-S1-casein. The sensor demonstrated good selectivity towards the α-casein as the target analyte and adequate recoveries from CIP final rinse wash samples. The sensor would be useful tool for monitoring allergen levels after cleaning procedures, providing additional data that may better inform upon wider food allergen risk management decision(s) that are made by food manufacturer. In particular, this sensor could potentially help validate or optimise cleaning practices for a given food manufacturing process.

  3. Development of a Microforce Sensor and Its Array Platform for Robotic Cell Microinjection Force Measurement

    OpenAIRE

    Yu Xie; Yunlei Zhou; Yuzi Lin; Lingyun Wang,; Wenming Xi

    2016-01-01

    Robot-assisted cell microinjection, which is precise and can enable a high throughput, is attracting interest from researchers. Conventional probe-type cell microforce sensors have some real-time injection force measurement limitations, which prevent their integration in a cell microinjection robot. In this paper, a novel supported-beam based cell micro-force sensor with a piezoelectric polyvinylidine fluoride film used as the sensing element is described, which was designed to solve the real...

  4. Sensor Fusion-based Event Detection in Wireless Sensor Networks

    NARCIS (Netherlands)

    Bahrepour, M.; Meratnia, N.; Havinga, P.J.M.

    2009-01-01

    Recently, Wireless Sensor Networks (WSN) community has witnessed an application focus shift. Although, monitoring was the initial application of wireless sensor networks, in-network data processing and (near) real-time actuation capability have made wireless sensor networks suitable candidate for ev

  5. Platform Based Design for Automotive Sensor Conditioning

    CERN Document Server

    Fanucci, L; Iozzi, F; Marino, C; Rocchi, A

    2011-01-01

    In this paper a general architecture suitable to interface several kinds of sensors for automotive applications is presented. A platform based design approach is pursued to improve system performance while minimizing time-to-market.. The platform is composed by an analog front-end and a digital section. The latter is based on a microcontroller core (8051 IP by Oregano) plus a set of dedicated hardware dedicated to the complex signal processing required for sensor conditioning. The microcontroller handles also the communication with external devices (as a PC) for data output and fast prototyping. A case study is presented concerning the conditioning of a Gyro yaw rate sensor for automotive applications. Measured performance results outperform current state-of-the-art commercial devices.

  6. Fuzzy-Based Sensor Fusion for Cognitive Radio-Based Vehicular Ad Hoc and Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mohammad Jalil Piran

    2015-01-01

    Full Text Available In wireless sensor networks, sensor fusion is employed to integrate the acquired data from diverse sensors to provide a unified interpretation. The best and most salient advantage of sensor fusion is to obtain high-level information in both statistical and definitive aspects, which cannot be attained by a single sensor. In this paper, we propose a novel sensor fusion technique based on fuzzy theory for our earlier proposed Cognitive Radio-based Vehicular Ad Hoc and Sensor Networks (CR-VASNET. In the proposed technique, we considered four input sensor readings (antecedents and one output (consequent. The employed mobile nodes in CR-VASNET are supposed to be equipped with diverse sensors, which cater to our antecedent variables, for example, The Jerk, Collision Intensity, and Temperature and Inclination Degree. Crash_Severity is considered as the consequent variable. The processing and fusion of the diverse sensory signals are carried out by fuzzy logic scenario. Accuracy and reliability of the proposed protocol, demonstrated by the simulation results, introduce it as an applicable system to be employed to reduce the causalities rate of the vehicles’ crashes.

  7. Sensors

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, H. [PBI-Dansensor A/S (Denmark); Toft Soerensen, O. [Risoe National Lab., Materials Research Dept. (Denmark)

    1999-10-01

    A new type of ceramic oxygen sensors based on semiconducting oxides was developed in this project. The advantage of these sensors compared to standard ZrO{sub 2} sensors is that they do not require a reference gas and that they can be produced in small sizes. The sensor design and the techniques developed for production of these sensors are judged suitable by the participating industry for a niche production of a new generation of oxygen sensors. Materials research on new oxygen ion conducting conductors both for applications in oxygen sensors and in fuel was also performed in this project and finally a new process was developed for fabrication of ceramic tubes by dip-coating. (EHS)

  8. Sensors

    CERN Document Server

    Pigorsch, Enrico

    1997-01-01

    This is the 5th edition of the Metra Martech Directory "EUROPEAN CENTRES OF EXPERTISE - SENSORS." The entries represent a survey of European sensors development. The new edition contains 425 detailed profiles of companies and research institutions in 22 countries. This is reflected in the diversity of sensors development programmes described, from sensors for physical parameters to biosensors and intelligent sensor systems. We do not claim that all European organisations developing sensors are included, but this is a good cross section from an invited list of participants. If you see gaps or omissions, or would like your organisation to be included, please send details. The data base invites the formation of effective joint ventures by identifying and providing access to specific areas in which organisations offer collaboration. This issue is recognised to be of great importance and most entrants include details of collaboration offered and sought. We hope the directory on Sensors will help you to find the ri...

  9. Suitability of Invertebrate and Vertebrate Cells in a Portable Impedance-Based Toxicity Sensor: Temperature Mediated Impacts on Long-Term Survival

    Science.gov (United States)

    2013-07-25

    Cell lines used and culture conditions tested. Cell line designation: tissue origin and species name Source & reference for each cell line Medi SF9 ...based biosensor. Animal group, cell line designation & animal origin (common name) Preferred Invertebrate cells SF9 : fall armyworm Concanav HvAM1

  10. LWT Based Sensor Node Signal Processing in Vehicle Surveillance Distributed Sensor Network

    Science.gov (United States)

    Cha, Daehyun; Hwang, Chansik

    Previous vehicle surveillance researches on distributed sensor network focused on overcoming power limitation and communication bandwidth constraints in sensor node. In spite of this constraints, vehicle surveillance sensor node must have signal compression, feature extraction, target localization, noise cancellation and collaborative signal processing with low computation and communication energy dissipation. In this paper, we introduce an algorithm for light-weight wireless sensor node signal processing based on lifting scheme wavelet analysis feature extraction in distributed sensor network.

  11. Electrochemical DNA Hybridization Sensors Based on Conducting Polymers

    Directory of Open Access Journals (Sweden)

    Md. Mahbubur Rahman

    2015-02-01

    Full Text Available Conducting polymers (CPs are a group of polymeric materials that have attracted considerable attention because of their unique electronic, chemical, and biochemical properties. This is reflected in their use in a wide range of potential applications, including light-emitting diodes, anti-static coating, electrochromic materials, solar cells, chemical sensors, biosensors, and drug-release systems. Electrochemical DNA sensors based on CPs can be used in numerous areas related to human health. This review summarizes the recent progress made in the development and use of CP-based electrochemical DNA hybridization sensors. We discuss the distinct properties of CPs with respect to their use in the immobilization of probe DNA on electrode surfaces, and we describe the immobilization techniques used for developing DNA hybridization sensors together with the various transduction methods employed. In the concluding part of this review, we present some of the challenges faced in the use of CP-based DNA hybridization sensors, as well as a future perspective.

  12. Soft sensor modeling based on Gaussian processes

    Institute of Scientific and Technical Information of China (English)

    XIONG Zhi-hua; HUANG Guo-hong; SHAO Hui-he

    2005-01-01

    In order to meet the demand of online optimal running, a novel soft sensor modeling approach based on Gaussian processes was proposed. The approach is moderately simple to implement and use without loss of performance. It is trained by optimizing the hyperparameters using the scaled conjugate gradient algorithm with the squared exponential covariance function employed. Experimental simulations show that the soft sensor modeling approach has the advantage via a real-world example in a refinery. Meanwhile, the method opens new possibilities for application of kernel methods to potential fields.

  13. Porous Alumina Based Capacitive MEMS RH Sensor

    CERN Document Server

    Juhasz, L; Timar-Horvath, Veronika; Desmulliez, Marc; Dhariwal, Resh

    2008-01-01

    The aim of a joint research and development project at the BME and HWU is to produce a cheap, reliable, low-power and CMOS-MEMS process compatible capacitive type relative humidity (RH) sensor that can be incorporated into a state-of-the-art, wireless sensor network. In this paper we discuss the preparation of our new capacitive structure based on post-CMOS MEMS processes and the methods which were used to characterize the thin film porous alumina sensing layer. The average sensitivity is approx. 15 pF/RH% which is more than a magnitude higher than the values found in the literature. The sensor is equipped with integrated resistive heating, which can be used for maintenance to reduce drift, or for keeping the sensing layer at elevated temperature, as an alternative method for temperature-dependence cancellation.

  14. Chemical Sensors Based on Piezoresistive Cantilever Array

    Institute of Scientific and Technical Information of China (English)

    于晓梅; 张大成; 王丛舜; 杜先锋; 王小宝; 阮勇

    2003-01-01

    U-shaped and rectangle piezoresistive cantilever arrays have been designed with the analysing results of stress,noise and sensitivity of the cantilevers. Based on silicon micromachining technology, the piezoresistive cantilevers were fabricated by using polysilicon as the piezoresistive materials. With the measurement results of noise and sensitivity, the Hooge factor is calculated to be 3 × 10-3, the gauge factor is 27, and the minimum detectable deflection of piezoresistive cantilevers are calculated to be 1.0nm for rectangle cantilever and 0.5 nm for the Ushaped cantilever at a 6 V bias voltage and a 1000 Hz measurement bandwidth. Using polymer-coated cantilevers as individual sensors, their responses to water vapour and ammonia were tested by measuring their output voltage signals. The measured results show that the sensor sensitivity to ammonia can reach a few ppm and the sensor responses are quick.

  15. Gas sensors based on nanostructured materials.

    Science.gov (United States)

    Jiménez-Cadena, Giselle; Riu, Jordi; Rius, F Xavier

    2007-11-01

    Gas detection is important for controlling industrial and vehicle emissions, household security and environmental monitoring. In recent decades many devices have been developed for detecting CO(2), CO, SO(2), O(2), O(3), H(2), Ar, N(2), NH(3), H(2)O and several organic vapours. However, the low selectivity or the high operation temperatures required when most gas sensors are used have prompted the study of new materials and the new properties that come about from using traditional materials in a nanostructured mode. In this paper, we have reviewed the main research studies that have been made of gas sensors that use nanomaterials. The main quality characteristics of these new sensing devices have enabled us to make a critical review of the possible advantages and drawbacks of these nanostructured material-based sensors.

  16. Electrochemical Sensors Based on Carbon Nanotubes

    Directory of Open Access Journals (Sweden)

    Md. Aminur Rahman

    2009-03-01

    Full Text Available This review focuses on recent contributions in the development of the electrochemical sensors based on carbon nanotubes (CNTs. CNTs have unique mechanical and electronic properties, combined with chemical stability, and behave electrically as a metal or semiconductor, depending on their structure. For sensing applications, CNTs have many advantages such as small size with larger surface area, excellent electron transfer promoting ability when used as electrodes modifier in electrochemical reactions, and easy protein immobilization with retention of its activity for potential biosensors. CNTs play an important role in the performance of electrochemical biosensors, immunosensors, and DNA biosensors. Various methods have been developed for the design of sensors using CNTs in recent years. Herein we summarize the applications of CNTs in the construction of electrochemical sensors and biosensors along with other nanomaterials and conducting polymers.

  17. ECCE Toolkit: Prototyping Sensor-Based Interaction

    Science.gov (United States)

    Bellucci, Andrea; Aedo, Ignacio; Díaz, Paloma

    2017-01-01

    Building and exploring physical user interfaces requires high technical skills and hours of specialized work. The behavior of multiple devices with heterogeneous input/output channels and connectivity has to be programmed in a context where not only the software interface matters, but also the hardware components are critical (e.g., sensors and actuators). Prototyping physical interaction is hindered by the challenges of: (1) programming interactions among physical sensors/actuators and digital interfaces; (2) implementing functionality for different platforms in different programming languages; and (3) building custom electronic-incorporated objects. We present ECCE (Entities, Components, Couplings and Ecosystems), a toolkit for non-programmers that copes with these issues by abstracting from low-level implementations, thus lowering the complexity of prototyping small-scale, sensor-based physical interfaces to support the design process. A user evaluation provides insights and use cases of the kind of applications that can be developed with the toolkit. PMID:28241502

  18. ECCE Toolkit: Prototyping Sensor-Based Interaction.

    Science.gov (United States)

    Bellucci, Andrea; Aedo, Ignacio; Díaz, Paloma

    2017-02-23

    Building and exploring physical user interfaces requires high technical skills and hours of specialized work. The behavior of multiple devices with heterogeneous input/output channels and connectivity has to be programmed in a context where not only the software interface matters, but also the hardware components are critical (e.g., sensors and actuators). Prototyping physical interaction is hindered by the challenges of: (1) programming interactions among physical sensors/actuators and digital interfaces; (2) implementing functionality for different platforms in different programming languages; and (3) building custom electronic-incorporated objects. We present ECCE (Entities, Components, Couplings and Ecosystems), a toolkit for non-programmers that copes with these issues by abstracting from low-level implementations, thus lowering the complexity of prototyping small-scale, sensor-based physical interfaces to support the design process. A user evaluation provides insights and use cases of the kind of applications that can be developed with the toolkit.

  19. ECCE Toolkit: Prototyping Sensor-Based Interaction

    Directory of Open Access Journals (Sweden)

    Andrea Bellucci

    2017-02-01

    Full Text Available Building and exploring physical user interfaces requires high technical skills and hours of specialized work. The behavior of multiple devices with heterogeneous input/output channels and connectivity has to be programmed in a context where not only the software interface matters, but also the hardware components are critical (e.g., sensors and actuators. Prototyping physical interaction is hindered by the challenges of: (1 programming interactions among physical sensors/actuators and digital interfaces; (2 implementing functionality for different platforms in different programming languages; and (3 building custom electronic-incorporated objects. We present ECCE (Entities, Components, Couplings and Ecosystems, a toolkit for non-programmers that copes with these issues by abstracting from low-level implementations, thus lowering the complexity of prototyping small-scale, sensor-based physical interfaces to support the design process. A user evaluation provides insights and use cases of the kind of applications that can be developed with the toolkit.

  20. Optic Fiber-Based Dynamic Pressure Sensor

    Institute of Scientific and Technical Information of China (English)

    Jiu-Lin Gan; Hai-Wen Cai; Jian-Xin Geng; Zheng-Qing Pan; Rong-Hui Qu; Zu-Jie Fang

    2008-01-01

    Weigh-in-Motion(WIM) technique is the process of measuring the dynamic tire forces of a moving vehicle and estimating the corresponding tire loads of the static vehicle. Compared with the static weigh station, WIM station is an efficient and cost effective choice that will minimize unneccessary stops and delay for truckers. The way to turn birefringence of single-mode fiber into a prime quality for a powerful and reliable sensor is shown. Preliminary results for the development of a weigh-in-motion (WIM) technique based on sagnac-loop sensor are presented. After a brief description of the sensor and its principle of operation, the theoretical model is developed. Then, a full characterization made in static conditions is presented.

  1. Electrospinning cellulose based nanofibers for sensor applications

    Science.gov (United States)

    Nartker, Steven

    2009-12-01

    Bacterial pathogens have recently become a serious threat to the food and water supply. A biosensor based on an electrochemical immunoassay has been developed for detecting food borne pathogens, such as Escherichia coli (E. coli) O157:H7. These sensors consist of several materials including, cellulose, cellulose nitrate, polyaniline and glass fibers. The current sensors have not been optimized in terms of microscale architecture and materials. The major problem associated with the current sensors is the limited concentration range of pathogens that provides a linear response on the concentration conductivity chart. Electrospinning is a process that can be used to create a patterned fiber mat design that will increase the linear range and lower the detection limit of these sensors by improving the microscale architecture. Using the electrospinning process to produce novel mats of cellulose nitrate will offer improved surface area, and the cellulose nitrate can be treated to further improve chemical interactions required for sensor activity. The macro and micro architecture of the sensor is critical to the performance of the sensors. Electrospinning technology can be used to create patterned architectures of nanofibers that will enhance sensor performance. To date electrospinning of cellulose nitrate has not been performed and optimization of the electrospinning process will provide novel materials suitable for applications such as filtration and sensing. The goal of this research is to identify and elucidate the primary materials and process factors necessary to produce cellulose nitrate nanofibers using the electrospinning process that will improve the performance of biosensors. Cellulose nitrate is readily dissolved in common organic solvents such as acetone, tetrahydrofuran (THF) and N,N dimethylformamide (DMF). These solvents can be mixed with other latent solvents such as ethanol and other alcohols to provide a solvent system with good electrospinning behavior

  2. Aminoquinoline based highly sensitive fluorescent sensor for lead(II) and aluminum(III) and its application in live cell imaging

    Energy Technology Data Exchange (ETDEWEB)

    Anand, Thangaraj; Sivaraman, Gandhi [School of Chemistry, Madurai Kamaraj University, Madurai 625021 (India); Mahesh, Ayyavu, E-mail: mahesh.a06@gmail.com [School of Biological Sciences, Madurai Kamaraj University, Madurai 625021 (India); Chellappa, Duraisamy, E-mail: dcmku123@gmail.com [School of Chemistry, Madurai Kamaraj University, Madurai 625021 (India)

    2015-01-01

    Highlights: • Aminoquinoline derivative was synthesized and used to recognize Pb{sup 2+}/Al{sup 3+}. • ANQ was high sensitive, selective and turn-on sensor for Pb{sup 2+}/Al{sup 3+}. • The Pb{sup 2+} detection limit (2.08 × 10{sup −9} mol L{sup −1}) is reported. • This fluorescence change was further supported by DFT/TD-DFT calculations. • The probe is applied successfully for recognizing intracellular Pb{sup 2+}/Al{sup 3+} within living cells. - Abstract: We have synthesized a new probe 5-((anthracen-9-ylmethylene) amino)quinolin-10-ol (ANQ) based on anthracene platform. The probe was tested for its sensing behavior toward heavy metal ions Hg{sup 2+}, Pb{sup 2+}, light metal Al{sup 3+} ion, alkali, alkaline earth, and transition metal ions by UV–visible and fluorescent techniques in ACN/H{sub 2}O mixture buffered with HEPES (pH 7.4). It shows high selectivity toward sensing Pb{sup 2+}/Al{sup 3+} metal ions. Importantly, 10-fold and 5- fold fluorescence enhancement at 429 nm was observed for probe upon complexation with Pb{sup 2+} and Al{sup 3+} ions, respectively. This fluorescence enhancement is attributable to the prevention of photoinduced electron transfer. The photonic studies indicate that the probe can be adopted as a sensitive fluorescent chemosensor for Pb{sup 2+} and Al{sup 3+} ions.

  3. Optical Slot-Waveguide Based Biochemical Sensors

    Directory of Open Access Journals (Sweden)

    Carlos Angulo Barrios

    2009-06-01

    Full Text Available Slot-waveguides allow light to be guided and strongly confined inside a nanometer-scale region of low refractive index. Thus stronger light-analyte interaction can be obtained as compared to that achievable by a conventional waveguide, in which the propagating beam is confined to the high-refractive-index core of the waveguide. In addition, slot-waveguides can be fabricated by employing CMOS compatible materials and technology, enabling miniaturization, integration with electronic, photonic and fluidic components in a chip, and mass production. These advantages have made the use of slot-waveguides for highly sensitive biochemical optical integrated sensors an emerging field. In this paper, recent achievements in slot-waveguide based biochemical sensing will be reviewed. These include slot-waveguide ring resonator based refractometric label-free biosensors, label-based optical sensing, and nano-opto-mechanical sensors.

  4. Neurochip Based on Light-addressable Potentiometric Sensor

    Institute of Scientific and Technical Information of China (English)

    Qingjun Liu; Hua Cai; Ying Xu; Lifeng Qin; Lijiang Wang; Ping Wang

    2006-01-01

    A novel neurochip based on light addressable potentiometric sensor (LAPS) is designed. Using its light addressable characteristic. The problems of the limitations of restricted discrete active sites of current neurochips, such as microelectrode array and field effect transistor array can be settled easily. Based on the theoretical analysis of the interface between cells and LAPS, spontaneously discharges of hippocampal neurons induced by Mg2+-free media treatment were recorded by LAPS. The results demonstrate that this kind of neurochip has potential to monitor electrophysiology of cultured cells in a non-invasive way.

  5. Hydrogen peroxide regulates cell adhesion through the redox sensor RPSA.

    Science.gov (United States)

    Vilas-Boas, Filipe; Bagulho, Ana; Tenente, Rita; Teixeira, Vitor H; Martins, Gabriel; da Costa, Gonçalo; Jerónimo, Ana; Cordeiro, Carlos; Machuqueiro, Miguel; Real, Carla

    2016-01-01

    To become metastatic, a tumor cell must acquire new adhesion properties that allow migration into the surrounding connective tissue, transmigration across endothelial cells to reach the blood stream and, at the site of metastasis, adhesion to endothelial cells and transmigration to colonize a new tissue. Hydrogen peroxide (H2O2) is a redox signaling molecule produced in tumor cell microenvironment with high relevance for tumor development. However, the molecular mechanisms regulated by H2O2 in tumor cells are still poorly known. The identification of H2O2-target proteins in tumor cells and the understanding of their role in tumor cell adhesion are essential for the development of novel redox-based therapies for cancer. In this paper, we identified Ribosomal Protein SA (RPSA) as a target of H2O2 and showed that RPSA in the oxidized state accumulates in clusters that contain specific adhesion molecules. Furthermore, we showed that RPSA oxidation improves cell adhesion efficiency to laminin in vitro and promotes cell extravasation in vivo. Our results unravel a new mechanism for H2O2-dependent modulation of cell adhesion properties and identify RPSA as the H2O2 sensor in this process. This work indicates that high levels of RPSA expression might confer a selective advantage to tumor cells in an oxidative environment.

  6. A Portable Laser Photoacoustic Methane Sensor Based on FPGA.

    Science.gov (United States)

    Wang, Jianwei; Wang, Huili; Liu, Xianyong

    2016-09-21

    A portable laser photoacoustic sensor for methane (CH₄) detection based on a field-programmable gate array (FPGA) is reported. A tunable distributed feedback (DFB) diode laser in the 1654 nm wavelength range is used as an excitation source. The photoacoustic signal processing was implemented by a FPGA device. A small resonant photoacoustic cell is designed. The minimum detection limit (1σ) of 10 ppm for methane is demonstrated.

  7. A Portable Laser Photoacoustic Methane Sensor Based on FPGA

    Science.gov (United States)

    Wang, Jianwei; Wang, Huili; Liu, Xianyong

    2016-01-01

    A portable laser photoacoustic sensor for methane (CH4) detection based on a field-programmable gate array (FPGA) is reported. A tunable distributed feedback (DFB) diode laser in the 1654 nm wavelength range is used as an excitation source. The photoacoustic signal processing was implemented by a FPGA device. A small resonant photoacoustic cell is designed. The minimum detection limit (1σ) of 10 ppm for methane is demonstrated. PMID:27657079

  8. Carbon nanotube based NEMS actuators and sensors

    Science.gov (United States)

    Forney, Michael; Poler, Jordan

    2011-03-01

    Single-walled carbon nanotubes (SWNTs) have been widely studied due to superior mechanical and electrical properties. We have grown vertically aligned SWNTs (VA-SWNTs) onto microcantilever (MC) arrays, which provides an architecture for novel actuators and sensors. Raman spectroscopy confirms that the CVD-grown nanotubes are SWNTs and SEM confirms aligned growth. As an actuator, this hybrid MC/VA-SWNT system can be electrostatically modulated. SWNTs are excellent electron acceptors, so we can charge up the VA-SWNT array by applying a voltage. The electrostatic repulsion among the charged SWNTs provides a surface stress that induces MC deflection. Simulation results show that a few electrons per SWNT are needed for measureable deflections, and experimental actuators are being characterized by SEM, Raman, and an AFM optical lever system. The applied voltage is sinusoidally modulated, and deflection is measured with a lock-in amplifier. These actuators could be used for nano-manipulation, release of drugs from a capsule, or nano-valves. As a sensor, this MC/VA-SWNT system offers an improved sensitivity for chemical and bio-sensing compared to surface functionalized MC-based sensors. Those sensors only have a 2D sensing surface, but a MC/VA-SWNT system has significantly more sensing surface because the VA-SWNTs extend microns off the MC surface.

  9. Submersible microbial fuel cell sensor for monitoring microbial activity and BOD in groundwater: Focusing on impact of anodic biofilm on sensor applicability

    DEFF Research Database (Denmark)

    Zhang, Yifeng; Angelidaki, Irini

    2011-01-01

    A sensor, based on a submersible microbial fuel cell (SUMFC), was developed for in situ monitoring of microbial activity and biochemical oxygen demand (BOD) in groundwater. Presence or absence of a biofilm on the anode was a decisive factor for the applicability of the sensor. Fresh anode...... was required for application of the sensor for microbial activity measurement, while biofilm‐colonized anode was needed for utilizing the sensor for BOD content measurement. The current density of SUMFC sensor equipped with a biofilm‐colonized anode showed linear relationship with BOD content, to up to 250 mg...

  10. Temperature Sensors Based on WGM Optical Resonators

    Science.gov (United States)

    Savchenkov, Anatoliy; Yu, Nan; Maleki, Lute; Itchenko, Vladimir; Matsko, Andrey; Strekalov, Dmitry

    2008-01-01

    A proposed technique for measuring temperature would exploit differences between the temperature dependences of the frequencies of two different electromagnetic modes of a whispering gallery-mode (WGM) optical resonator. An apparatus based on this technique was originally intended to be part of a control system for stabilizing a laser frequency in the face of temperature fluctuations. When suitably calibrated, apparatuses based on this technique could also serve as precise temperature sensors for purposes other than stabilization of lasers. A sensor according to the proposal would include (1) a transparent WGM dielectric resonator having at least two different sets of modes characterized by different thermo-optical constants and (2) optoelectronic instrumentation for measuring the difference between the temperature-dependent shifts of the resonance frequencies of the two sets of modes.

  11. Ultrasonic Sensor Based 3D Mapping & Localization

    Directory of Open Access Journals (Sweden)

    Shadman Fahim Ahmad

    2016-04-01

    Full Text Available This article provides a basic level introduction to 3D mapping using sonar sensors and localization. It describes the methods used to construct a low-cost autonomous robot along with the hardware and software used as well as an insight to the background of autonomous robotic 3D mapping and localization. We have also given an overview to what the future prospects of the robot may hold in 3D based mapping.

  12. Fluorescence-lifetime-based sensors for anions

    Science.gov (United States)

    Teichmann, Maria; Draxler, Sonja; Kieslinger, Dietmar; Lippitsch, Max E.

    1997-05-01

    Sensing of anions has been investigated using the fluorescence decaytime as the information carrier. The sensing mechanism is based on the coextraction of an anion and a proton, and the presence of a fluorophore with a rather long fluorescence decaytime inside the membrane to act as a pH indicator. The relevant theory is discussed shortly. As an example a sensor for nitrate is shown, and the influence of ionic additives on the working function has been investigated.

  13. Miniaturized optical sensors based on lens arrays

    DEFF Research Database (Denmark)

    Hanson, Steen Grüner; Jakobsen, M.L.; Larsen, H.E.

    2005-01-01

    A suite of optical sensors based on the use of lenticular arrays for probing mechanical deflections will be displayed. The optical systems are well suited for miniaturization, and utilize speckles as the information-carriers. This implementation allows for acquiring directional information of the...... of the displacement. Systems for probing lateral displacements and in-plane vibrations (1-D and 2-D) are displayed, as will systems for probing angular velocity and torsional vibrations of rotating objects....

  14. Nanomaterial-based robust oxygen sensor

    Science.gov (United States)

    Goswami, Kisholoy; Sampathkumaran, Uma; Alam, Maksudul; Tseng, Derek; Majumdar, Arun K.; Kazemi, Alex A.

    2007-09-01

    Since the TWA flight 800 accident in July 1996, significant emphasis has been placed on fuel tank safety. The Federal Aviation Administration (FAA) has focused research to support two primary methods of fuel tank protection - ground-based and on-board - both involving fuel tank inerting. Ground-based fuel tank inerting involves some combination of fuel scrubbing and ullage washing with Nitrogen Enriched Air (NEA) while the airplane is on the ground (applicable to all or most operating transport airplanes). On-board fuel tank inerting involves ullage washing with OBIGGS (on-board inert gas generating system), a system that generates NEA during aircraft operations. An OBIGGS generally encompasses an air separation module (ASM) to generate NEA, a compressor, storage tanks, and a distribution system. Essential to the utilization of OBIGGS is an oxygen sensor that can operate inside the aircraft's ullage and assess the effectiveness of the inerting systems. OBIGGS can function economically by precisely knowing when to start and when to stop. Toward achieving these goals, InnoSense LLC is developing an all-optical fuel tank ullage sensor (FTUS) prototype for detecting oxygen in the ullage of an aircraft fuel tank in flight conditions. Data would be presented to show response time and wide dynamic range of the sensor in simulated flight conditions and fuel tank environment.

  15. Dielectric Sensors Based on Electromagnetic Energy Tunneling

    Directory of Open Access Journals (Sweden)

    Omar Siddiqui

    2015-03-01

    Full Text Available We show that metallic wires embedded in narrow waveguide bends and channels demonstrate resonance behavior at specific frequencies. The electromagnetic energy at these resonances tunnels through the narrow waveguide channels with almost no propagation losses. Under the tunneling behavior, high-intensity electromagnetic fields are produced in the vicinity of the metallic wires. These intense field resonances can be exploited to build highly sensitive dielectric sensors. The sensor operation is explained with the help of full-wave simulations. A practical setup consisting of a 3D waveguide bend is presented to experimentally observe the tunneling phenomenon. The tunneling frequency is predicted by determining the input impedance minima through a variational formula based on the Green function of a probe-excited parallel plate waveguide.

  16. Bend-insensitive fiber based vibration sensor

    Science.gov (United States)

    Xu, Yanping; Lu, Ping; Baset, Farhana; Bhardwaj, Vedula Ravi; Bao, Xiaoyi

    2014-05-01

    We report two novel fiber-optic vibration sensors based on standard telecom bend-insensitive fiber (BIF). A tapered BIF forming a fiber Mach-Zehnder interferometer could measure continuous and damped vibration from 1 Hz up to 500 kHz. An enclosed microcantilever is fabricated inside the BIF by chemical etching and fusion spliced with a readout singlemode fiber that exhibits a frequency range from 5 Hz to 10 kHz with high signal-to-noise ratio (SNR) up to 68 dB. The unique double cladding structure of the BIF ensures both sensors with advantages of compactness, high resistance to the external disturbance and stronger mechanical strength.

  17. Adaptive Sensing Based on Profiles for Sensor Systems

    Directory of Open Access Journals (Sweden)

    Yoshiteru Ishida

    2009-10-01

    Full Text Available This paper proposes a profile-based sensing framework for adaptive sensor systems based on models that relate possibly heterogeneous sensor data and profiles generated by the models to detect events. With these concepts, three phases for building the sensor systems are extracted from two examples: a combustion control sensor system for an automobile engine, and a sensor system for home security. The three phases are: modeling, profiling, and managing trade-offs. Designing and building a sensor system involves mapping the signals to a model to achieve a given mission.

  18. Bidirectional Promoter Engineering for Single Cell MicroRNA Sensors in Embryonic Stem Cells.

    Science.gov (United States)

    Sladitschek, Hanna L; Neveu, Pierre A

    2016-01-01

    MicroRNAs have emerged as important markers and regulators of cell identity. Precise measurements of cellular miRNA levels rely traditionally on RNA extraction and thus do not allow to follow miRNA expression dynamics at the level of single cells. Non-invasive miRNA sensors present an ideal solution but they critically depend on the performance of suitable ubiquitous promoters that reliably drive expression both in pluripotent and differentiated cell types. Here we describe the engineering of bidirectional promoters that drive the expression of precise ratiometric fluorescent miRNA sensors in single mouse embryonic stem cells (mESCs) and their differentiated derivatives. These promoters are based on combinations of the widely used CAG, EF1α and PGK promoters as well as the CMV and PGK enhancers. miR-142-3p, which is known to be bimodally expressed in mESCs, served as a model miRNA to gauge the precision of the sensors. The performance of the resulting miRNA sensors was assessed by flow cytometry in single stable transgenic mESCs undergoing self-renewal or differentiation. EF1α promoters arranged back-to-back failed to drive the robustly correlated expression of two transgenes. Back-to-back PGK promoters were shut down during mESC differentiation. However, we found that a back-to-back arrangement of CAG promoters with four CMV enhancers provided both robust expression in mESCs undergoing differentiation and the best signal-to-noise for measurement of miRNA activity in single cells among all the sensors we tested. Such a bidirectional promoter is therefore particularly well suited to study the dynamics of miRNA expression during cell fate transitions at the single cell level.

  19. Bidirectional Promoter Engineering for Single Cell MicroRNA Sensors in Embryonic Stem Cells.

    Directory of Open Access Journals (Sweden)

    Hanna L Sladitschek

    Full Text Available MicroRNAs have emerged as important markers and regulators of cell identity. Precise measurements of cellular miRNA levels rely traditionally on RNA extraction and thus do not allow to follow miRNA expression dynamics at the level of single cells. Non-invasive miRNA sensors present an ideal solution but they critically depend on the performance of suitable ubiquitous promoters that reliably drive expression both in pluripotent and differentiated cell types. Here we describe the engineering of bidirectional promoters that drive the expression of precise ratiometric fluorescent miRNA sensors in single mouse embryonic stem cells (mESCs and their differentiated derivatives. These promoters are based on combinations of the widely used CAG, EF1α and PGK promoters as well as the CMV and PGK enhancers. miR-142-3p, which is known to be bimodally expressed in mESCs, served as a model miRNA to gauge the precision of the sensors. The performance of the resulting miRNA sensors was assessed by flow cytometry in single stable transgenic mESCs undergoing self-renewal or differentiation. EF1α promoters arranged back-to-back failed to drive the robustly correlated expression of two transgenes. Back-to-back PGK promoters were shut down during mESC differentiation. However, we found that a back-to-back arrangement of CAG promoters with four CMV enhancers provided both robust expression in mESCs undergoing differentiation and the best signal-to-noise for measurement of miRNA activity in single cells among all the sensors we tested. Such a bidirectional promoter is therefore particularly well suited to study the dynamics of miRNA expression during cell fate transitions at the single cell level.

  20. Photonic Crystal Sensors Based on Porous Silicon

    Directory of Open Access Journals (Sweden)

    Claudia Pacholski

    2013-04-01

    Full Text Available Porous silicon has been established as an excellent sensing platform for the optical detection of hazardous chemicals and biomolecular interactions such as DNA hybridization, antigen/antibody binding, and enzymatic reactions. Its porous nature provides a high surface area within a small volume, which can be easily controlled by changing the pore sizes. As the porosity and consequently the refractive index of an etched porous silicon layer depends on the electrochemial etching conditions photonic crystals composed of multilayered porous silicon films with well-resolved and narrow optical reflectivity features can easily be obtained. The prominent optical response of the photonic crystal decreases the detection limit and therefore increases the sensitivity of porous silicon sensors in comparison to sensors utilizing Fabry-Pérot based optical transduction. Development of porous silicon photonic crystal sensors which allow for the detection of analytes by the naked eye using a simple color change or the fabrication of stacked porous silicon photonic crystals showing two distinct optical features which can be utilized for the discrimination of analytes emphasize its high application potential.

  1. Photonic crystal sensors based on porous silicon.

    Science.gov (United States)

    Pacholski, Claudia

    2013-04-09

    Porous silicon has been established as an excellent sensing platform for the optical detection of hazardous chemicals and biomolecular interactions such as DNA hybridization, antigen/antibody binding, and enzymatic reactions. Its porous nature provides a high surface area within a small volume, which can be easily controlled by changing the pore sizes. As the porosity and consequently the refractive index of an etched porous silicon layer depends on the electrochemial etching conditions photonic crystals composed of multilayered porous silicon films with well-resolved and narrow optical reflectivity features can easily be obtained. The prominent optical response of the photonic crystal decreases the detection limit and therefore increases the sensitivity of porous silicon sensors in comparison to sensors utilizing Fabry-Pérot based optical transduction. Development of porous silicon photonic crystal sensors which allow for the detection of analytes by the naked eye using a simple color change or the fabrication of stacked porous silicon photonic crystals showing two distinct optical features which can be utilized for the discrimination of analytes emphasize its high application potential.

  2. Research of marine sensor web based on SOA and EDA

    Science.gov (United States)

    Jiang, Yongguo; Dou, Jinfeng; Guo, Zhongwen; Hu, Keyong

    2015-04-01

    A great deal of ocean sensor observation data exists, for a wide range of marine disciplines, derived from in situ and remote observing platforms, in real-time, near-real-time and delayed mode. Ocean monitoring is routinely completed using sensors and instruments. Standardization is the key requirement for exchanging information about ocean sensors and sensor data and for comparing and combining information from different sensor networks. One or more sensors are often physically integrated into a single ocean `instrument' device, which often brings in many challenges related to diverse sensor data formats, parameters units, different spatiotemporal resolution, application domains, data quality and sensors protocols. To face these challenges requires the standardization efforts aiming at facilitating the so-called Sensor Web, which making it easy to provide public access to sensor data and metadata information. In this paper, a Marine Sensor Web, based on SOA and EDA and integrating the MBARI's PUCK protocol, IEEE 1451 and OGC SWE 2.0, is illustrated with a five-layer architecture. The Web Service layer and Event Process layer are illustrated in detail with an actual example. The demo study has demonstrated that a standard-based system can be built to access sensors and marine instruments distributed globally using common Web browsers for monitoring the environment and oceanic conditions besides marine sensor data on the Web, this framework of Marine Sensor Web can also play an important role in many other domains' information integration.

  3. Performance evaluation of sensor allocation algorithm based on covariance control

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The covariance control capability of sensor allocation algorithms based on covariance control strategy is an important index to evaluate the performance of these algorithms. Owing to lack of standard performance metric indices to evaluate covariance control capability, sensor allocation ratio, etc, there are no guides to follow in the design procedure of sensor allocation algorithm in practical applications. To meet these demands, three quantified performance metric indices are presented, which are average covariance misadjustment quantity (ACMQ), average sensor allocation ratio (ASAR) and matrix metric influence factor (MMIF), where ACMQ, ASAR and MMIF quantify the covariance control capability, the usage of sensor resources and the robustness of sensor allocation algorithm, respectively. Meanwhile, a covariance adaptive sensor allocation algorithm based on a new objective function is proposed to improve the covariance control capability of the algorithm based on information gain. The experiment results show that the proposed algorithm have the advantage over the preceding sensor allocation algorithm in covariance control capability and robustness.

  4. Optimal Sensor Decision Based on Particle Filter

    Institute of Scientific and Technical Information of China (English)

    XU Meng; WANG Hong-wei; HU Shi-qiang

    2006-01-01

    A novel infrared and radar synergistic tracking algorithm, which is based on the idea of closed loop control, and target's motion model identification and particle filter approach, was put forward. In order to improve the observability and filtering divergence of infrared search and tracking, the unscented Kalman filter algorithm that has stronger ability of non-linear approximation was adopted. The polynomial and least square method based on radar and IRST measurements to identify the parameters of the model was proposed, and a "pseudo sensor" was suggested to estimate the target position according to the identified model even if the radar is turned off. At last,the average Kullback-Leibler discrimination distance based on particle filter was used to measure the tracking performance, based on tracking performance and fuzzy stochastic decision, the idea of closed loop was used to retrieve the module parameter of "pseudo sensor". The experimental result indicates that the algorithm can not only limit the radar activity effectively but also keep the tracking accuracy of active/passive system well.

  5. ON-LINE MONITORING OF BIOMASS CONCENTRATION BASED ON A CAPACITANCE SENSOR: ASSESSING THE METHODOLOGY FOR DIFFERENT BACTERIA AND YEAST HIGH CELL DENSITY FED-BATCH CULTURES

    Directory of Open Access Journals (Sweden)

    A. C. L. Horta

    2015-12-01

    Full Text Available Abstract The performance of an in-situ capacitance sensor for on-line monitoring of biomass concentration was evaluated for some of the most important microorganisms in the biotechnology industry: Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris and Bacillus megaterium. A total of 33 batch and fed-batch cultures were carried out in a bench-scale bioreactor and biomass formation trends were followed by dielectric measurements during the growth phase as well as the induction phase, for 5 recombinant E. coli strains. Permittivity measurements and viable cellular concentrations presented a linear correlation for all the studied conditions. In addition, the permittivity signal was further used for inference of the cellular growth rate. The estimated specific growth rates mirrored the main trends of the metabolic states of the different cells and they can be further used for setting-up control strategies in fed-batch cultures.

  6. Synthesis and photophysical properties of water-soluble sulfonato-Salen-type Schiff bases and their applications of fluorescence sensors for Cu2+ in water and living cells.

    Science.gov (United States)

    Zhou, Li; Cai, Peiying; Feng, Yan; Cheng, Jinghui; Xiang, Haifeng; Liu, Jin; Wu, Di; Zhou, Xiangge

    2012-07-20

    A series of water-soluble sulfonato-Salen-type ligands derived from different diamines including 1,2-ethylenediamine (Et-1-Et-4), 1,2-cyclohexanediamine (Cy-1 and Cy-2), 1,2-phenylenediamine (Ph-1-Ph-3 and PhMe-1-PhMe-4), and dicyano-1,2-ethenediamine (CN-1) has been designed and prepared. Sulfonate groups of ligands ensure good stability and solubility in water without affecting their excited state properties. These ligands exhibit strong UV/Vis-absorption and blue, green, or orange fluorescence. Time-dependent-density functional theory calculations have been undertaken to reveal the influence of ligand nature, especially sulfonate groups, on the frontier molecular orbitals. Since their fluorescence is selectively quenched by Cu(2+), the sulfonato-Salen-type ligands can be used as highly selective and sensitive turn-off fluorescence sensors for the detection of Cu(2+) in water and fluorescence imaging in living cells.

  7. Microfluidic cell culture systems with integrated sensors for drug screening

    Science.gov (United States)

    Grist, Samantha; Yu, Linfen; Chrostowski, Lukas; Cheung, Karen C.

    2012-03-01

    Cell-based testing is a key step in drug screening for cancer treatments. A microfluidic platform can permit more precise control of the cell culture microenvironment, such as gradients in soluble factors. These small-scale devices also permit tracking of low cell numbers. As a new screening paradigm, a microscale system for integrated cell culture and drug screening promises to provide a simple, scalable tool to apply standardized protocols used in cellular response assays. With the ability to dynamically control the microenvironment, we can create temporally varying drug profiles to mimic physiologically measured profiles. In addition, low levels of oxygen in cancerous tumors have been linked with drug resistance and decreased likelihood of successful treatment and patient survival. Our work also integrates a thin-film oxygen sensor with a microfluidic oxygen gradient generator which will in future allow us to create spatial oxygen gradients and study effects of hypoxia on cell response to drug treatment. In future, this technology promises to improve cell-based validation in the drug discovery process, decreasing the cost and increasing the speed in screening large numbers of compounds.

  8. Circuit Design of Surface Acoustic Wave Based Micro Force Sensor

    Directory of Open Access Journals (Sweden)

    Yuanyuan Li

    2014-01-01

    Full Text Available Pressure sensors are commonly used in industrial production and mechanical system. However, resistance strain, piezoresistive sensor, and ceramic capacitive pressure sensors possess limitations, especially in micro force measurement. A surface acoustic wave (SAW based micro force sensor is designed in this paper, which is based on the theories of wavelet transform, SAW detection, and pierce oscillator circuits. Using lithium niobate as the basal material, a mathematical model is established to analyze the frequency, and a peripheral circuit is designed to measure the micro force. The SAW based micro force sensor is tested to show the reasonable design of detection circuit and the stability of frequency and amplitude.

  9. Waveguide-based optical chemical sensor

    Science.gov (United States)

    Grace, Karen M.; Swanson, Basil I.; Honkanen, Seppo

    2007-03-13

    The invention provides an apparatus and method for highly selective and sensitive chemical sensing. Two modes of laser light are transmitted through a waveguide, refracted by a thin film host reagent coating on the waveguide, and analyzed in a phase sensitive detector for changes in effective refractive index. Sensor specificity is based on the particular species selective thin films of host reagents which are attached to the surface of the planar optical waveguide. The thin film of host reagents refracts laser light at different refractive indices according to what species are forming inclusion complexes with the host reagents.

  10. Optical stimulator for vision-based sensors

    DEFF Research Database (Denmark)

    Rössler, Dirk; Pedersen, David Arge Klevang; Benn, Mathias

    2014-01-01

    We have developed an optical stimulator system for vision-based sensors. The stimulator is an efficient tool for stimulating a camera during on-ground testing with scenes representative of spacecraft flights. Such scenes include starry sky, planetary objects, and other spacecraft. The optical...... stimulator is used as a test bench to simulate high-precision navigation by different types of camera systems that are used onboard spacecraft, planetary rovers, and for spacecraft rendezvous and proximity maneuvers. Careful hardware design and preoperational calibration of the stimulator result in high...

  11. On Orbit Immuno-Based, Label-Free, White Blood Cell Counting System with MicroElectroMechanical Sensor (MEMS) Technology (OILWBCS-MEMS) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Aurora Flight Sciences Corporation and partner, Draper Laboratory, propose to develop an on-orbit immuno-based label-free white blood cell counting system using MEMS...

  12. On Orbit Immuno-Based, Label-Free, White Blood Cell Counting System with MicroElectroMechanical Sensor (MEMS) Technology (OILWBCS-MEMS) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Aurora Flight Sciences Corporation and our partner, Draper Laboratory, propose to develop an on orbit immuno-based, label-free, white blood cell counting system for...

  13. Wave front sensor based on holographic optical elements

    Science.gov (United States)

    Kovalev, M. S.; Krasin, G. K.; Malinina, P. I.; Odinokov, S. B.; Sagatelyan, H. R.

    2016-08-01

    A wavefront sensor (WFS) based on holographic optical elements, namely computer generated Fourier holograms is proposed as a perspective alternative to the Shack-Hartmann sensor. A possibility of single and multimode sensor and the dependence of their characteristics were investigated.

  14. Hydrogel-based sensor for CO2 measurements

    NARCIS (Netherlands)

    Herber, S.; Olthuis, W.; Bergveld, P.; Berg, van den A.

    2004-01-01

    A hydrogel-based sensor is presented for CO2 measurements. The sensor consists of a pressure sensor and porous silicon cover. A pH-sensitive hydrogel is confined between the two parts. Furthermore the porous cover contains a bicarbonate solution and a gaspermeable membrane. CO2 reacts with the solut

  15. Resource Discovery in Activity-Based Sensor Networks

    DEFF Research Database (Denmark)

    Bucur, Doina; Bardram, Jakob

    This paper proposes a service discovery protocol for sensor networks that is specifically tailored for use in humancentered pervasive environments. It uses the high-level concept of computational activities (as logical bundles of data and resources) to give sensors in Activity-Based Sensor Networ...

  16. Organic Thin-Film Transistor (OTFT)-Based Sensors

    OpenAIRE

    Daniel Elkington; Nathan Cooling; Warwick Belcher; Dastoor, Paul C; Xiaojing Zhou

    2014-01-01

    Organic thin film transistors have been a popular research topic in recent decades and have found applications from flexible displays to disposable sensors. In this review, we present an overview of some notable articles reporting sensing applications for organic transistors with a focus on the most recent publications. In particular, we concentrate on three main types of organic transistor-based sensors: biosensors, pressure sensors and “e-nose”/vapour sensors.

  17. Organic Thin-Film Transistor (OTFT-Based Sensors

    Directory of Open Access Journals (Sweden)

    Daniel Elkington

    2014-04-01

    Full Text Available Organic thin film transistors have been a popular research topic in recent decades and have found applications from flexible displays to disposable sensors. In this review, we present an overview of some notable articles reporting sensing applications for organic transistors with a focus on the most recent publications. In particular, we concentrate on three main types of organic transistor-based sensors: biosensors, pressure sensors and “e-nose”/vapour sensors.

  18. Design, Fabrication, and Validation of Membrane-Based Sensors

    OpenAIRE

    2012-01-01

    Hair cell structures are one of the most common forms of sensing elements found in nature. In humans, approximately 16,000 auditory hair cells can be found in the cochlea of the ear. Each hair cell contains a stereocilia, which is the primary structure for sound transduction. This study looks to develop and characterize a bilayer lipid membrane (BLM) operated artificial hair cell sensor that resembles the stereocilia of the human ear. To develop this sensor, a flexible substrate with interna...

  19. Amylin Detection with a Miniature Optical-Fiber Based Sensor

    Science.gov (United States)

    Liu, Zhaowen; Ann, Matsko; Hughes, Adam; Reeves, Mark

    We present results of a biosensor based on shifts in the localized surface plasmon resonance of gold nanoparticles self-assembled on the end of an optical fiber. This system allows for detection of protein expression in low sensing volumes and for scanning in cell cultures and tissue samples. Positive and negative controls were done using biotin/avidin and the BSA/Anti-BSA system. These demonstrate that detection is specific and sensitive to nanomolar levels. Sensing of amylin, an important protein for pancreatic function, was performed with polyclonal and monoclonal antibodies. The measured data demonstrates the difference in sensitivity to the two types of antibodies, and titration experiments establish the sensitivity of the sensor. Further experiments demonstrate that the sensor can be regenerated and then reused.

  20. Biomimetic chemical sensors using bioengineered olfactory and taste cells

    Science.gov (United States)

    Du, Liping; Zou, Ling; Zhao, Luhang; Wang, Ping; Wu, Chunsheng

    2014-01-01

    Biological olfactory and taste systems are natural chemical sensing systems with unique performances for the detection of environmental chemical signals. With the advances in olfactory and taste transduction mechanisms, biomimetic chemical sensors have achieved significant progress due to their promising prospects and potential applications. Biomimetic chemical sensors exploit the unique capability of biological functional components for chemical sensing, which are often sourced from sensing units of biological olfactory or taste systems at the tissue level, cellular level, or molecular level. Specifically, at the cellular level, there are mainly two categories of cells have been employed for the development of biomimetic chemical sensors, which are natural cells and bioengineered cells, respectively. Natural cells are directly isolated from biological olfactory and taste systems, which are convenient to achieve. However, natural cells often suffer from the undefined sensing properties and limited amount of identical cells. On the other hand, bioengineered cells have shown decisive advantages to be applied in the development of biomimetic chemical sensors due to the powerful biotechnology for the reconstruction of the cell sensing properties. Here, we briefly summarized the most recent advances of biomimetic chemical sensors using bioengineered olfactory and taste cells. The development challenges and future trends are discussed as well. PMID:25482234

  1. Development of a Microforce Sensor and Its Array Platform for Robotic Cell Microinjection Force Measurement.

    Science.gov (United States)

    Xie, Yu; Zhou, Yunlei; Lin, Yuzi; Wang, Lingyun; Xi, Wenming

    2016-04-06

    Robot-assisted cell microinjection, which is precise and can enable a high throughput, is attracting interest from researchers. Conventional probe-type cell microforce sensors have some real-time injection force measurement limitations, which prevent their integration in a cell microinjection robot. In this paper, a novel supported-beam based cell micro-force sensor with a piezoelectric polyvinylidine fluoride film used as the sensing element is described, which was designed to solve the real-time force-sensing problem during a robotic microinjection manipulation, and theoretical mechanical and electrical models of the sensor function are derived. Furthermore, an array based cell-holding device with a trapezoidal microstructure is micro-fabricated, which serves to improve the force sensing speed and cell manipulation rates. Tests confirmed that the sensor showed good repeatability and a linearity of 1.82%. Finally, robot-assisted zebrafish embryo microinjection experiments were conducted. These results demonstrated the effectiveness of the sensor working with the robotic cell manipulation system. Moreover, the sensing structure, theoretical model, and fabrication method established in this study are not scale dependent. Smaller cells, e.g., mouse oocytes, could also be manipulated with this approach.

  2. Development of a Microforce Sensor and Its Array Platform for Robotic Cell Microinjection Force Measurement

    Directory of Open Access Journals (Sweden)

    Yu Xie

    2016-04-01

    Full Text Available Robot-assisted cell microinjection, which is precise and can enable a high throughput, is attracting interest from researchers. Conventional probe-type cell microforce sensors have some real-time injection force measurement limitations, which prevent their integration in a cell microinjection robot. In this paper, a novel supported-beam based cell micro-force sensor with a piezoelectric polyvinylidine fluoride film used as the sensing element is described, which was designed to solve the real-time force-sensing problem during a robotic microinjection manipulation, and theoretical mechanical and electrical models of the sensor function are derived. Furthermore, an array based cell-holding device with a trapezoidal microstructure is micro-fabricated, which serves to improve the force sensing speed and cell manipulation rates. Tests confirmed that the sensor showed good repeatability and a linearity of 1.82%. Finally, robot-assisted zebrafish embryo microinjection experiments were conducted. These results demonstrated the effectiveness of the sensor working with the robotic cell manipulation system. Moreover, the sensing structure, theoretical model, and fabrication method established in this study are not scale dependent. Smaller cells, e.g., mouse oocytes, could also be manipulated with this approach.

  3. All-plastic fiber-based pressure sensor

    DEFF Research Database (Denmark)

    Bundalo, Ivan-Lazar; Lwin, Richard; Leon-Saval, Sergio

    2016-01-01

    We present a feasibility study and a prototype of an all-plastic fiber-based pressure sensor. The sensor is based on long period gratings inscribed for the first time to the best of our knowledge by a CO2 laser in polymethyl methacrylate (PMMA) microstructured fibers and coupled to a pod......-like transducer that converts pressure to strain. The sensor prototype was characterized for pressures up to 150 mbars, and various parameters related to its construction were also characterized in order to enhance sensitivity. We consider this sensor in the context of future applications in endoscopic pressure...... sensors....

  4. All-plastic fiber-based pressure sensor.

    Science.gov (United States)

    Bundalo, Ivan-Lazar; Lwin, Richard; Leon-Saval, Sergio; Argyros, Alexander

    2016-02-01

    We present a feasibility study and a prototype of an all-plastic fiber-based pressure sensor. The sensor is based on long period gratings inscribed for the first time to the best of our knowledge by a CO2 laser in polymethyl methacrylate (PMMA) microstructured fibers and coupled to a pod-like transducer that converts pressure to strain. The sensor prototype was characterized for pressures up to 150 mbars, and various parameters related to its construction were also characterized in order to enhance sensitivity. We consider this sensor in the context of future applications in endoscopic pressure sensors.

  5. Monitoring of yeast cell concentration using a micromachined impedance sensor

    NARCIS (Netherlands)

    Krommenhoek, E.E.; Gardeniers, J.G.E.; Bomer, J.G.; Berg, van den A.; Li, X.; Ottens, M.; Wielen, van der L.A.M.; Dedem, van G.W.K.; Leeuwen, M.; Gulik, van W.M.; Heijnen, J.J.

    2005-01-01

    The paper describes the design, modelling and experimental characterization of a micromachined impedance sensor for on-line monitoring of the viable yeast cell concentration (biomass) in a miniaturized cell assay. Measurements in a Saccharomyces cerevisiae cell culture show that the permittivity of

  6. Monitoring of yeast cell concentration using a micromachnined impedance sensor

    NARCIS (Netherlands)

    Krommenhoek, E.E.; Gardeniers, J.G.E.; Bomer, J.G.; Berg, van den A.; Li, X.; Ottens, M.; Wielen, van der L.A.M.; Dedem, van G.W.K.; Leeuwen, van M.; Gulik, van W.M.; Heijnen, J.J.

    2006-01-01

    This paper describes the design, modeling and experimental characterization of a micromachined impedance sensor for on-line monitoring of the viable yeast cell concentration (biomass) in a miniaturized cell assay. Measurements in Saccharomyces cerevisiae cell culture show that the characteristic fre

  7. Optical Fiber Sensors Based on Nanoparticle-Embedded Coatings

    Directory of Open Access Journals (Sweden)

    Aitor Urrutia

    2015-01-01

    Full Text Available The use of nanoparticles (NPs in scientific applications has attracted the attention of many researchers in the last few years. The use of NPs can help researchers to tune the physical characteristics of the sensing coating (thickness, roughness, specific area, refractive index, etc. leading to enhanced sensors with response time or sensitivity better than traditional sensing coatings. Additionally, NPs also offer other special properties that depend on their nanometric size, and this is also a source of new sensing applications. This review focuses on the current status of research in the use of NPs within coatings in optical fiber sensing. Most used sensing principles in fiber optics are briefly described and classified into several groups: absorbance-based sensors, interferometric sensors, fluorescence-based sensors, fiber grating sensors, and resonance-based sensors, among others. For each sensor group, specific examples of the utilization of NP-embedded coatings in their sensing structure are reported.

  8. Sensors Based on Spectroscopy of Guided Waves

    Science.gov (United States)

    Homola, Jiří

    The last two decades have witnessed remarkable progress in the develpment of affinity biosensors and their applications in areas such as environmental protection, biotechnology, medical diagnostics, drug screening, food safety, and security. An affinity biosensor consists of a transducer and a biological recognition element which is able to interact with a selected analyte. Various optical methods have been exploited in biosensors including fluorescence spectroscopy, interferometry (reflectometric white light interferometry, modal interferometry in optical waveguide structures), and spectroscopy of guided modes of optical waveguides. Optical biosensors based on spectroscopy of guided modes of optical waveguides - grating coupler, resonant mirror, and surface plasmon resonance (SPR) - rely on the measurement of binding-induced refractive index changes and thus are label-free technologies. This paper reviews fundamentals of optical sensors based on spectroscopy of guided modes of optical waveguides and their applications.

  9. Distributed query processing in flash-based sensor networks

    Institute of Scientific and Technical Information of China (English)

    Jianliang XU; Xueyan TANG; Wang-Chien LEE

    2008-01-01

    Wireless sensor networks are used in a large array of applications to capture,collect,and analyze physical environmental data.Many existing sensor systems instruct sensor nodes to report their measurements to central repositories outside the network,which is expensive in energy cost.Recent technological advances in flash memory have given rise to the development of storagecentric sensor networks,where sensor nodes are equipped with high-capacity flash memory storage such that sensor data can b.e stored and managed inside the network to reduce expensive communication.This novel architecture calls for new data management techniques to fully exploit distributed in-network data storage.This paper describes some of our research on distributed query processing in such flash-based sensor networks.Of particular interests are the issues that arise in the design of storage management and indexing structures combining sensor system workload and read/write/erase characteristics of flash memory.

  10. Evaluation of a Multi-Parameter Sensor for Automated, Continuous Cell Culture Monitoring in Bioreactors

    Science.gov (United States)

    Pappas, D.; Jeevarajan, A.; Anderson, M. M.

    2004-01-01

    Compact and automated sensors are desired for assessing the health of cell cultures in biotechnology experiments in microgravity. Measurement of cell culture medium allows for the optirn.jzation of culture conditions on orbit to maximize cell growth and minimize unnecessary exchange of medium. While several discrete sensors exist to measure culture health, a multi-parameter sensor would simplify the experimental apparatus. One such sensor, the Paratrend 7, consists of three optical fibers for measuring pH, dissolved oxygen (p02), dissolved carbon dioxide (pC02) , and a thermocouple to measure temperature. The sensor bundle was designed for intra-arterial placement in clinical patients, and potentially can be used in NASA's Space Shuttle and International Space Station biotechnology program bioreactors. Methods: A Paratrend 7 sensor was placed at the outlet of a rotating-wall perfused vessel bioreactor system inoculated with BHK-21 (baby hamster kidney) cells. Cell culture medium (GTSF-2, composed of 40% minimum essential medium, 60% L-15 Leibovitz medium) was manually measured using a bench top blood gas analyzer (BGA, Ciba-Corning). Results: A Paratrend 7 sensor was used over a long-term (>120 day) cell culture experiment. The sensor was able to track changes in cell medium pH, p02, and pC02 due to the consumption of nutrients by the BHK-21. When compared to manually obtained BGA measurements, the sensor had good agreement for pH, p02, and pC02 with bias [and precision] of 0.02 [0.15], 1 mm Hg [18 mm Hg], and -4.0 mm Hg [8.0 mm Hg] respectively. The Paratrend oxygen sensor was recalibrated (offset) periodically due to drift. The bias for the raw (no offset or recalibration) oxygen measurements was 42 mm Hg [38 mm Hg]. The measured response (rise) time of the sensor was 20 +/- 4s for pH, 81 +/- 53s for pC02, 51 +/- 20s for p02. For long-term cell culture measurements, these response times are more than adequate. Based on these findings , the Paratrend sensor could

  11. Zirconia-based solid state chemical gas sensors

    CERN Document Server

    Zhuiykov, S

    2000-01-01

    This paper presents an overview of chemical gas sensors, based on solid state technology, that are sensitive to environmental gases, such as O sub 2 , SO sub x , NO sub x , CO sub 2 and hydrocarbons. The paper is focussed on performance of electrochemical gas sensors that are based on zirconia as a solid electrolyte. The paper considers sensor structures and selection of electrode materials. Impact of interfaces on sensor performance is discussed. This paper also provides a brief overview of electrochemical properties of zirconia and their effect on sensor performance. Impact of auxiliary materials on sensors performance characteristics, such as sensitivity, selectivity, response time and recovery time, is also discussed. Dual gas sensors that can be applied for simultaneous monitoring of the concentration of both oxygen and other gas phase components, are briefly considered

  12. Physiological sensor signals classification for healthcare using sensor data fusion and case-based reasoning.

    Science.gov (United States)

    Begum, Shahina; Barua, Shaibal; Ahmed, Mobyen Uddin

    2014-07-03

    Today, clinicians often do diagnosis and classification of diseases based on information collected from several physiological sensor signals. However, sensor signal could easily be vulnerable to uncertain noises or interferences and due to large individual variations sensitivity to different physiological sensors could also vary. Therefore, multiple sensor signal fusion is valuable to provide more robust and reliable decision. This paper demonstrates a physiological sensor signal classification approach using sensor signal fusion and case-based reasoning. The proposed approach has been evaluated to classify Stressed or Relaxed individuals using sensor data fusion. Physiological sensor signals i.e., Heart Rate (HR), Finger Temperature (FT), Respiration Rate (RR), Carbon dioxide (CO2) and Oxygen Saturation (SpO2) are collected during the data collection phase. Here, sensor fusion has been done in two different ways: (i) decision-level fusion using features extracted through traditional approaches; and (ii) data-level fusion using features extracted by means of Multivariate Multiscale Entropy (MMSE). Case-Based Reasoning (CBR) is applied for the classification of the signals. The experimental result shows that the proposed system could classify Stressed or Relaxed individual 87.5% accurately compare to an expert in the domain. So, it shows promising result in the psychophysiological domain and could be possible to adapt this approach to other relevant healthcare systems.

  13. Physiological Sensor Signals Classification for Healthcare Using Sensor Data Fusion and Case-Based Reasoning

    Directory of Open Access Journals (Sweden)

    Shahina Begum

    2014-07-01

    Full Text Available Today, clinicians often do diagnosis and classification of diseases based on information collected from several physiological sensor signals. However, sensor signal could easily be vulnerable to uncertain noises or interferences and due to large individual variations sensitivity to different physiological sensors could also vary. Therefore, multiple sensor signal fusion is valuable to provide more robust and reliable decision. This paper demonstrates a physiological sensor signal classification approach using sensor signal fusion and case-based reasoning. The proposed approach has been evaluated to classify Stressed or Relaxed individuals using sensor data fusion. Physiological sensor signals i.e., Heart Rate (HR, Finger Temperature (FT, Respiration Rate (RR, Carbon dioxide (CO2 and Oxygen Saturation (SpO2 are collected during the data collection phase. Here, sensor fusion has been done in two different ways: (i decision-level fusion using features extracted through traditional approaches; and (ii data-level fusion using features extracted by means of Multivariate Multiscale Entropy (MMSE. Case-Based Reasoning (CBR is applied for the classification of the signals. The experimental result shows that the proposed system could classify Stressed or Relaxed individual 87.5% accurately compare to an expert in the domain. So, it shows promising result in the psychophysiological domain and could be possible to adapt this approach to other relevant healthcare systems.

  14. Information-based sensor management for the intelligent tasking of ground penetrating radar and electromagnetic induction sensors in landmine detection pre-screening

    Science.gov (United States)

    Kolba, Mark P.; Collins, Leslie M.

    2010-04-01

    Previous work has introduced a framework for information-based sensor management that is capable of tasking multiple sensors searching for targets among a set of discrete objects or in a cell grid. However, in many real-world scenarios-- such as detecting landmines along a lane or road--an unknown number of targets are present in a continuous spatial region of interest. Consequently, this paper introduces a grid-free sensor management approach that allows multiple sensors to be managed in a sequential search for targets in a grid-free spatial region. Simple yet expressive Gaussian target models are introduced to model the spatial target responses that are observed by the sensors. The sensor manager is then formulated using a Bayesian approach, and sensors are directed to make new observations that maximize the expected information gain between the posterior density on the target parameters after a new observation and the current posterior target parameter density. The grid-free sensor manager is applied to a set of real landmine detection data collected with ground penetrating radar (GPR) and electromagnetic induction (EMI) sensors at a U.S. government test site. Results are presented that compare the performance of the sensor manager with the performance of an unmanaged joint pre-screener that fuses individual GPR and EMI pre-screeners. The sensor manager is demonstrated to provide improved detection performance while requiring substantially fewer sensor observations than are made with the unmanaged joint pre-screening approach.

  15. Optical Sensors Based on Plastic Fibers

    Science.gov (United States)

    Bilro, Lúcia; Alberto, Nélia; Pinto, João L.; Nogueira, Rogério

    2012-01-01

    The recent advances of polymer technology allowed the introduction of plastic optical fiber in sensor design. The advantages of optical metrology with plastic optical fiber have attracted the attention of the scientific community, as they allow the development of low-cost or cost competitive systems compared with conventional technologies. In this paper, the current state of the art of plastic optical fiber technology will be reviewed, namely its main characteristics and sensing advantages. Several measurement techniques will be described, with a strong focus on interrogation approaches based on intensity variation in transmission and reflection. The potential applications involving structural health monitoring, medicine, environment and the biological and chemical area are also presented. PMID:23112707

  16. Carbon-Nanotube-Based Chemical Gas Sensor

    Science.gov (United States)

    Kaul, Arunpama B.

    2010-01-01

    Conventional thermal conductivity gauges (e.g. Pirani gauges) lend themselves to applications such as leak detectors, or in gas chromatographs for identifying various gas species. However, these conventional gauges are physically large, operate at high power, and have a slow response time. A single-walled carbon-nanotube (SWNT)-based chemical sensing gauge relies on differences in thermal conductance of the respective gases surrounding the CNT as it is voltage-biased, as a means for chemical identification. Such a sensor provides benefits of significantly reduced size and compactness, fast response time, low-power operation, and inexpensive manufacturing since it can be batch-fabricated using Si integrated-circuit (IC) process technology.

  17. Optical Sensors Based on Plastic Fibers

    Directory of Open Access Journals (Sweden)

    Rogério Nogueira

    2012-09-01

    Full Text Available The recent advances of polymer technology allowed the introduction of plastic optical fiber in sensor design. The advantages of optical metrology with plastic optical fiber have attracted the attention of the scientific community, as they allow the development of low-cost or cost competitive systems compared with conventional technologies. In this paper, the current state of the art of plastic optical fiber technology will be reviewed, namely its main characteristics and sensing advantages. Several measurement techniques will be described, with a strong focus on interrogation approaches based on intensity variation in transmission and reflection. The potential applications involving structural health monitoring, medicine, environment and the biological and chemical area are also presented.

  18. ELECTRIC FIELD SENSORS BASED ON MEMS TECHNOLOGY

    Institute of Scientific and Technical Information of China (English)

    Gong Chao; Xia Shanhong; Deng Kai; Bai Qiang; Chen Shaofeng

    2005-01-01

    The design and optimization of two types of novel miniature vibrating Electric Field Sensors (EFSs) based on Micro Electro Mechanical Systems (MEMS) technology are presented.They have different structures and vibrating modes. The volume is much smaller than other types of charge-induced EFSs such as field-mills. As miniaturizing, the induced signal is reduced enormously and a high sensitive circuit is needed to detect it. Elaborately designed electrodes can increase the amplitude of the output current, making the detecting circuit simplified and improving the signal-to-noise ratio. Computer simulations for different structural parameters of the EFSs and vibrating methods have been carried out by Finite Element Method (FEM). It is proved that the new structures are realizable and the output signals are detectable.

  19. Detection of Salmonella typhimurium using phage-based magnetostrictive sensor

    Science.gov (United States)

    Lakshmanan, Ramji S.; Hu, Jing; Guntupalli, Rajesh; Wan, Jiehui; Huang, Shichu; Yang, Hong; Petrenko, Valery A.; Barbaree, James M.; Chin, Bryan A.

    2006-05-01

    This article presents a contactless, remote sensing Salmonella typhimurium sensor based on the principle of magnetostriction. Magnetostrictive materials have been used widely for various types of sensor systems. In this work, the use of a magnetostrictive material for the detection of Salmonella typhimurium has been established. The mass of the bacteria attached to the sensor causes changes in the resonance frequency of the sensor. Filamentous bacteriophage was used as a probe order to ensure specific and selective binding of the bacteria onto the sensor surface. Thus changes in response of the sensor due to the mass added onto the sensor caused by specific attachment of bacteria can be monitored in absence of any contact to the sensor. The response of the sensor due to increasing concentrations (from 5x101 to 5x10 8 cfu/ml) of the bacteria was studied. A reduction in the physical dimensions enhances the sensitivity of these sensors and hence different dimensions of the sensor ribbons were studied. For a 2mm x 0.1mm x 0.02mm the detection limit was observed to be of the order of 10 4 cfu/mL and for a sensor of 1mm x 0.2mm x 0.02mm a reduced detection limit of 10 3 cfu/mL was achieved.

  20. Sensor-based demand controlled ventilation

    Energy Technology Data Exchange (ETDEWEB)

    De Almeida, A.T. [Universidade de Coimbra (Portugal). Dep. Eng. Electrotecnica; Fisk, W.J. [Lawrence Berkeley National Lab., CA (United States)

    1997-07-01

    In most buildings, occupancy and indoor pollutant emission rates vary with time. With sensor-based demand-controlled ventilation (SBDCV), the rate of ventilation (i.e., rate of outside air supply) also varies with time to compensate for the changes in pollutant generation. In other words, SBDCV involves the application of sensing, feedback and control to modulate ventilation. Compared to ventilation without feedback, SBDCV offers two potential advantages: (1) better control of indoor pollutant concentrations; and (2) lower energy use and peak energy demand. SBDCV has the potential to improve indoor air quality by increasing the rate of ventilation when indoor pollutant generation rates are high and occupants are present. SBDCV can also save energy by decreasing the rate of ventilation when indoor pollutant generation rates are low or occupants are absent. After providing background information on indoor air quality and ventilation, this report provides a relatively comprehensive discussion of SBDCV. Topics covered in the report include basic principles of SBDCV, sensor technologies, technologies for controlling air flow rates, case studies of SBDCV, application of SBDCV to laboratory buildings, and research needs. SBDCV appears to be an increasingly attractive technology option. Based on the review of literature and theoretical considerations, the application of SBDCV has the potential to be cost-effective in applications with the following characteristics: (a) a single or small number of dominant pollutants, so that ventilation sufficient to control the concentration of the dominant pollutants provides effective control of all other pollutants; (b) large buildings or rooms with unpredictable temporally variable occupancy or pollutant emission; and (c) climates with high heating or cooling loads or locations with expensive energy.

  1. A highly sensitive and selective turn-on fluorogenic and chromogenic sensor based on BODIPY-functionalized magnetic nanoparticles for detecting lead in living cells.

    Science.gov (United States)

    Son, Hyunjong; Lee, Hye Young; Lim, Jung Mi; Kang, Dongmin; Han, Won Seok; Lee, Shim Sung; Jung, Jong Hwa

    2010-10-11

    A new fluoro-chromogenic chemosensor based on BODIPY-functionalized Fe(3)O(4)@SiO(2) core/shell nanoparticles 1 has been prepared. Chemosensor 1 exhibits a high affinity and selectivity for Pb(2+) over competing metal ions tested. Moreover, confocal microscopy, and flow cytometry experiments established that 1 can be used for detecting Pb(2+) levels within living cell.

  2. Development of GaN-based micro chemical sensor nodes

    Science.gov (United States)

    Son, Kyung-ah; Prokopuk, Nicholas; George, Thomas; Moon, Jeong S.

    2005-01-01

    Sensors based on III-N technology are gaining significant interest due to their potential for monolithic integration of RF transceivers and light sources and the capability of high temperature operations. We are developing a GaN-based micro chemical sensor node for remote detection of chemical toxins, and present electrical responses of AlGaN/GaN HEMT (High Electron Mobility Transistor) sensors to chemical toxins as well as other common gases.

  3. Galvanic Cell Type Sensor for Soil Moisture Analysis.

    Science.gov (United States)

    Gaikwad, Pramod; Devendrachari, Mruthyunjayachari Chattanahalli; Thimmappa, Ravikumar; Paswan, Bhuneshwar; Raja Kottaichamy, Alagar; Makri Nimbegondi Kotresh, Harish; Thotiyl, Musthafa Ottakam

    2015-07-21

    Here we report the first potentiometric sensor for soil moisture analysis by bringing in the concept of Galvanic cells wherein the redox energies of Al and conducting polyaniline are exploited to design a battery type sensor. The sensor consists of only simple architectural components, and as such they are inexpensive and lightweight, making it suitable for on-site analysis. The sensing mechanism is proved to be identical to a battery type discharge reaction wherein polyaniline redox energy changes from the conducting to the nonconducting state with a resulting voltage shift in the presence of soil moisture. Unlike the state of the art soil moisture sensors, a signal derived from the proposed moisture sensor is probe size independent, as it is potentiometric in nature and, hence, can be fabricated in any shape or size and can provide a consistent output signal under the strong aberration conditions often encountered in soil moisture analysis. The sensor is regenerable by treating with 1 M HCl and can be used for multiple analysis with little read out hysteresis. Further, a portable sensor is fabricated which can provide warning signals to the end user when the moisture levels in the soil go below critically low levels, thereby functioning as a smart device. As the sensor is inexpensive, portable, and potentiometric, it opens up avenues for developing effective and energy efficient irrigation strategies, understanding the heat and water transfer at the atmosphere-land interface, understanding soil mechanics, forecasting the risk of natural calamities, and so on.

  4. Neural network-based sensor signal accelerator.

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, M. C.

    2000-10-16

    A strategy has been developed to computationally accelerate the response time of a generic electronic sensor. The strategy can be deployed as an algorithm in a control system or as a physical interface (on an embedded microcontroller) between a slower responding external sensor and a higher-speed control system. Optional code implementations are available to adjust algorithm performance when computational capability is limited. In one option, the actual sensor signal can be sampled at the slower rate with adaptive linear neural networks predicting the sensor's future output and interpolating intermediate synthetic output values. In another option, a synchronized collection of predictors sequentially controls the corresponding synthetic output voltage. Error is adaptively corrected in both options. The core strategy has been demonstrated with automotive oxygen sensor data. A prototype interface device is under construction. The response speed increase afforded by this strategy could greatly offset the cost of developing a replacement sensor with a faster physical response time.

  5. Graphene Electronic Device Based Biosensors and Chemical Sensors

    Science.gov (United States)

    Jiang, Shan

    Two-dimensional layered materials, such as graphene and MoS2, are emerging as an exciting material system for a new generation of atomically thin electronic devices. With their ultrahigh surface to volume ratio and excellent electrical properties, 2D-layered materials hold the promise for the construction of a generation of chemical and biological sensors with unprecedented sensitivity. In my PhD thesis, I mainly focus on graphene based electronic biosensors and chemical sensors. In the first part of my thesis, I demonstrated the fabrication of graphene nanomesh (GNM), which is a graphene thin film with a periodic array of holes punctuated in it. The periodic holes introduce long periphery active edges that provide a high density of functional groups (e.g. carboxylic groups) to allow for covalent grafting of specific receptor molecules for chemical and biosensor applications. After covalently functionalizing the GNM with glucose oxidase, I managed to make a novel electronic sensor which can detect glucose as well as pH change. In the following part of my thesis I demonstrate the fabrication of graphene-hemin conjugate for nitric oxide detection. The non-covalent functionalization through pi-pi stacking interaction allows reliable immobilization of hemin molecules on graphene without damaging the graphene lattice to ensure the highly sensitive and specific detection of nitric oxide. The graphene-hemin nitric oxide sensor is capable of real-time monitoring of nitric oxide concentrations, which is of central importance for probing the diverse roles of nitric oxide in neurotransmission, cardiovascular systems, and immune responses. Our studies demonstrate that the graphene-hemin sensors can respond rapidly to nitric oxide in physiological environments with sub-nanomolar sensitivity. Furthermore, in vitro studies show that the graphene-hemin sensors can be used for the detection of nitric oxide released from macrophage cells and endothelial cells, demonstrating their

  6. Optical fiber based slide tactile sensor for underwater robots

    Institute of Scientific and Technical Information of China (English)

    TAN Ding-zhong; WANG Qi-ming; SONG Rui-han; YAO Xin; GU Yi-hua

    2008-01-01

    In the underwater environment,many visual sensors don't work,and many sensors which work well for robots working in space or on land can not be used underwater.Therefore,an optical fiber slide tactile sensor was designed based on the inner modulation mechanism of optical fibers.The principles and structure of the sensor are explained in detail.Its static and dynamic characteristics were analyzed theoretically and then simulated.A dynamic characteristic model was built and the simulation made using the GA based neural network.In order to improve sensor response,the recognition model of the sensor was designed based on the'inverse solution'principle of neural networks,increasing the control precision and the sensitivity of the manipulator.

  7. Applications of FBG-based sensors to ground stability monitoring

    Institute of Scientific and Technical Information of China (English)

    An-Bin Huang; Chien-Chih Wang; Jui-Ting Lee; Yen-Te Ho

    2016-01-01

    Over the past few decades, many optical fiber sensing techniques have been developed. Among these available sensing methods, optical fiber Bragg grating (FBG) is probably the most popular one. With its unique capabilities, FBG-based geotechnical sensors can be used as a sensor array for distributive (profile) measurements, deployed under water (submersible), for localized high resolution and/or dif-ferential measurements. The authors have developed a series of FBG-based transducers that include inclination, linear displacement and gauge/differential pore pressure sensors. Techniques that involve the field deployment of FBG inclination, extension and pore-pressure sensor arrays for automated slope stability and ground subsidence monitoring have been developed. The paper provides a background of FBG and the design concepts behind the FBG-based field monitoring sensors. Cases of field monitoring using the FBG sensor arrays are presented, and their practical implications are discussed.

  8. Distance Based Fault detection in wireless sensor network

    Directory of Open Access Journals (Sweden)

    Ayasha Siddiqua

    2013-05-01

    Full Text Available Wireless Sensor Network (WSNs have become a new information collection and monitoring solution for a variety of application. In WSN, sensor nodes have strong hardware and software restrictionin terms of processing power, memory capability, power supply and communication throughput. Due to these restrictions, fault may occur in sensor. This paper presents a distance based fault detection (DBFDmethod for wireless sensor network using the average of confidence level and sensed data of sensor node. Simulation results show that sensor nodes with permanent faults and without fault which was judged as faulty are identified with high accuracy for a wide range of fault rate, and keep false alarm rate for different levels of sensor fault model and also correct nodes are identified by accuracy.

  9. Sensors and signal transduction pathways in vertebrate cell volume regulation

    DEFF Research Database (Denmark)

    Hoffmann, Else K; Pedersen, Stine F

    2006-01-01

    will be discussed. In contrast to the simple pathway of osmosensing in yeast, cells from vertebrate organisms appear to exhibit multiple volume sensing systems, the specific mechanism(s) activated being cell type- and stimulus-dependent. Candidate sensors include integrins and growth factor receptors, while other...

  10. Catalytic sensor based continuous emissions monitor in boiler applications

    Energy Technology Data Exchange (ETDEWEB)

    Schubert, P.F.; Devita, S.P.; Budd, A. [Monitor Labs, Inc., Englewood, CO (United States)

    1997-12-31

    Until the development of reliable, solid state NO{sub x} sensors, sensor based continuous monitoring of NO{sub x} emissions was primarily by predictive or parametric methods which use data collected from other types of sensors to predict what a NO{sub x} sensor would read. While some success has been achieved using these methods, direct measurement of desired exhaust gases provides greater confidence than can be achieved using modeling approaches. The recent development of a solid state catalytic NO{sub x} sensor allowed development of an analyzer combining the advantages of sensors with the direct measurement capability of traditional continuous emissions monitors. The new sensor based analyzer, the CEMcat{trademark} continuous emissions monitor, utilizes a single, compact, sensor module containing the three sensors for NO{sub x}, CO and O{sub 2} measurement. Its development was sponsored by the Gas Research Institute (GRI), and additional support was provided by the Southern California Gas Co. The use of the CEMcat analyzer to monitor emissions from gas turbine engines and large gas-fired reciprocating engines has previously been reported. In these applications, the CEMcat analyzer demonstrated its capability to meet 40CFR60 relative accuracy requirements. This sensor based analyzer has recently been applied in boiler applications.

  11. Polymer-based stress sensor with integrated readout

    DEFF Research Database (Denmark)

    Thaysen, Jacob; Yalcinkaya, Arda Deniz; Vettiger, P.;

    2002-01-01

    We present a polymer-based mechanical sensor with an integrated strain sensor element. Conventionally, silicon has been used as a piezoresistive material due to its high gauge factor and thereby high sensitivity to strain changes in the sensor. By using the fact that the polymer SU-8 [1] is much...... softer than silicon and that a gold resistor is easily incorporated in SU-8, we have proven that a SU-8-based cantilever sensor is almost as sensitive to stress changes as the silicon piezoresistive cantilever. First, the surface stress sensing principle is discussed, from which it can be shown...

  12. Coal mine gas monitoring system based on wireless sensor network

    Institute of Scientific and Technical Information of China (English)

    WANG Jian; WANG Ru-lin; WANG Xue-min; SHEN Chuan-he

    2007-01-01

    Based on the nowadays'condition.it is urgent that the gas detection cable communication system must be replaced by the wireless communication systems.The wireless sensors distributed in the environment can achieve the intelligent gas monitoring system.Apply with multilayer data fuse to design working tactics,and import the artificial neural networks to analyze detecting result.The wireless sensors system communicates with the controI center through the optical fiber cable.All the gas sensor nodes distributed in coal mine are combined into an intelligent,flexible structure wireless network system.forming coal mine gas monitoring system based on wireless sensor network.

  13. CMOS-based Integrated Wavefront Sensor

    NARCIS (Netherlands)

    De Lima Monteiro, D.W.

    2002-01-01

    This thesis addresses the design, implementation and performance of an integrated Hartmann-Shack wavefront sensor suitable for real-time operation and compatible with a standard technology. A wavefront sensor can be used for the detection of distortions in the profile of a light beam or of an optica

  14. Calculating Traffic based on Road Sensor Data

    NARCIS (Netherlands)

    Bisseling, Rob; Gao, Fengnan; Hafkenscheid, Patrick; Idema, Reijer; Jetka, Tomasz; Guerra Ones, Valia; Sikora, Monika

    2014-01-01

    Road sensors gather a lot of statistical data about traffic. In this paper, we discuss how a measure for the amount of traffic on the roads can be derived from this data, such that the measure is independent of the number and placement of sensors, and the calculations can be performed quickly for la

  15. Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells.

    Science.gov (United States)

    Hou, Bi-Huei; Takanaga, Hitomi; Grossmann, Guido; Chen, Li-Qing; Qu, Xiao-Qing; Jones, Alexander M; Lalonde, Sylvie; Schweissgut, Oliver; Wiechert, Wolfgang; Frommer, Wolf B

    2011-10-27

    Knowledge of the in vivo levels, distribution and flux of ions and metabolites is crucial to our understanding of physiology in both healthy and diseased states. The quantitative analysis of the dynamics of ions and metabolites with subcellular resolution in vivo poses a major challenge for the analysis of metabolic processes. Genetically encoded Förster resonance energy transfer (FRET) sensors can be used for real-time in vivo detection of metabolites. FRET sensor proteins, for example, for glucose, can be targeted genetically to any cellular compartment, or even to subdomains (e.g., a membrane surface), by adding signal sequences or fusing the sensors to specific proteins. The sensors can be used for analyses in individual mammalian cells in culture, in tissue slices and in intact organisms. Applications include gene discovery, high-throughput drug screens or systematic analysis of regulatory networks affecting uptake, efflux and metabolism. Quantitative analyses obtained with the help of FRET sensors for glucose or other ions and metabolites provide valuable data for modeling of flux. Here we provide a detailed protocol for monitoring glucose levels in the cytosol of mammalian cell cultures through the use of FRET glucose sensors; moreover, the protocol can be used for other ions and metabolites and for analyses in other organisms, as has been successfully demonstrated in bacteria, yeast and even intact plants. The whole procedure typically takes ∼4 d including seeding and transfection of mammalian cells; the FRET-based analysis of transfected cells takes ∼5 h.

  16. Wearable Sensor System Powered by a Biofuel Cell for Detection of Lactate Levels in Sweat.

    Science.gov (United States)

    Garcia, S O; Ulyanova, Y V; Figueroa-Teran, R; Bhatt, K H; Singhal, S; Atanassov, P

    An NAD(+)-dependent enzymatic sensor with biofuel cell power source system for non-invasive monitoring of lactate in sweat was designed, developed, and tested. The sensor component, based on lactate dehydrogenase, showed linear current response with increasing lactate concentrations with limits of detection from 5 to 100 mM lactate and sensitivity of 0.2 µA.mM(-1) in the presence of target analyte. In addition to the sensor patch a power source was also designed, developed and tested. The power source was a biofuel cell designed to oxidize glucose via glucose oxidase. The biofuel cell showed excellent performance, achieving over 80 mA at 0.4 V (16 mW) in a footprint of 3.5 × 3.5 × 0.7 cm. Furthermore, in order to couple the sensor to the power source, system electronic components were designed and fabricated. These consisted of an energy harvester (EH) and a micropotentiostat (MP). The EH was employed for harvesting power provided by the biofuel cell as well as up-converting the voltage to 3.0 V needed for the operation of the MP. The sensor was attached to MP for chronoamperometric detection of lactate. The Sensor Patch System was demonstrated under laboratory conditions.

  17. Dynamic gesture recognition based on multiple sensors fusion technology.

    Science.gov (United States)

    Wenhui, Wang; Xiang, Chen; Kongqiao, Wang; Xu, Zhang; Jihai, Yang

    2009-01-01

    This paper investigates the roles of a three-axis accelerometer, surface electromyography sensors and a webcam for dynamic gesture recognition. A decision-level multiple sensor fusion method based on action elements is proposed to distinguish a set of 20 kinds of dynamic hand gestures. Experiments are designed and conducted to collect three kinds of sensor data stream simultaneously during gesture implementation and compare the performance of different subsets in gesture recognition. Experimental results from three subjects show that the combination of three kinds of sensor achieves recognition accuracies at 87.5%-91.8%, which are higher largely than that of the single sensor conditions. This study is valuable to realize continuous and dynamic gesture recognition based on multiple sensor fusion technology for multi-model interaction.

  18. Interoperability in wireless sensor networks based on IEEE 1451 standard

    OpenAIRE

    Higuera Portilla, Jorge Eduardo; Polo Cantero, José

    2012-01-01

    The syntactic and semantic interoperability is a challenge of the Wireless Sensor Networks (WSN) with smart sensors in pervasive computing environments to increase their harmonization in a wide variety of applications. This chapter contains a detailed description of interoperability in heterogeneous WSN using the IEEE 1451 standard. This work focuses on personal area networks (PAN) with smart sensors and actuators. Also, a technical, syntactic and semantic levels of interoperability based on ...

  19. Highly Sensitive Flexible Magnetic Sensor Based on Anisotropic Magnetoresistance Effect.

    Science.gov (United States)

    Wang, Zhiguang; Wang, Xinjun; Li, Menghui; Gao, Yuan; Hu, Zhongqiang; Nan, Tianxiang; Liang, Xianfeng; Chen, Huaihao; Yang, Jia; Cash, Syd; Sun, Nian-Xiang

    2016-11-01

    A highly sensitive flexible magnetic sensor based on the anisotropic magnetoresistance effect is fabricated. A limit of detection of 150 nT is observed and excellent deformation stability is achieved after wrapping of the flexible sensor, with bending radii down to 5 mm. The flexible AMR sensor is used to read a magnetic pattern with a thickness of 10 μm that is formed by ferrite magnetic inks.

  20. Multi-Wavelength Based Optical Density Sensor for Autonomous Monitoring of Microalgae.

    Science.gov (United States)

    Jia, Fei; Kacira, Murat; Ogden, Kimberly L

    2015-09-02

    A multi-wavelength based optical density sensor unit was designed, developed, and evaluated to monitor microalgae growth in real time. The system consisted of five main components including: (1) laser diode modules as light sources; (2) photodiodes as detectors; (3) driver circuit; (4) flow cell; and (5) sensor housing temperature controller. The sensor unit was designed to be integrated into any microalgae culture system for both real time and non-real time optical density measurements and algae growth monitoring applications. It was shown that the sensor unit was capable of monitoring the dynamics and physiological changes of the microalgae culture in real-time. Algae biomass concentration was accurately estimated with optical density measurements at 650, 685 and 780 nm wavelengths used by the sensor unit. The sensor unit was able to monitor cell concentration as high as 1.05 g·L(-1) (1.51 × 10⁸ cells·mL(-1)) during the culture growth without any sample preparation for the measurements. Since high cell concentrations do not need to be diluted using the sensor unit, the system has the potential to be used in industrial microalgae cultivation systems for real time monitoring and control applications that can lead to improved resource use efficiency.

  1. Patient Posture Monitoring System Based on Flexible Sensors

    Directory of Open Access Journals (Sweden)

    Youngsu Cha

    2017-03-01

    Full Text Available Monitoring patients using vision cameras can cause privacy intrusion problems. In this paper, we propose a patient position monitoring system based on a patient cloth with unobtrusive sensors. We use flexible sensors based on polyvinylidene fluoride, which is a flexible piezoelectric material. Theflexiblesensorsareinsertedintopartsclosetothekneeandhipoftheloosepatientcloth. We measure electrical signals from the sensors caused by the piezoelectric effect when the knee and hip in the cloth are bent. The measured sensor outputs are transferred to a computer via Bluetooth. We use a custom-made program to detect the position of the patient through a rule-based algorithm and the sensor outputs. The detectable postures are based on six human motions in and around a bed. The proposed system can detect the patient positions with a success rate over 88 percent for three patients.

  2. Reagentless, Structure-Switching, Electrochemical Aptamer-Based Sensors.

    Science.gov (United States)

    Schoukroun-Barnes, Lauren R; Macazo, Florika C; Gutierrez, Brenda; Lottermoser, Justine; Liu, Juan; White, Ryan J

    2016-06-12

    The development of structure-switching, electrochemical, aptamer-based sensors over the past ∼10 years has led to a variety of reagentless sensors capable of analytical detection in a range of sample matrices. The crux of this methodology is the coupling of target-induced conformation changes of a redox-labeled aptamer with electrochemical detection of the resulting altered charge transfer rate between the redox molecule and electrode surface. Using aptamer recognition expands the highly sensitive detection ability of electrochemistry to a range of previously inaccessible analytes. In this review, we focus on the methods of sensor fabrication and how sensor signaling is affected by fabrication parameters. We then discuss recent studies addressing the fundamentals of sensor signaling as well as quantitative characterization of the analytical performance of electrochemical aptamer-based sensors. Although the limits of detection of reported electrochemical aptamer-based sensors do not often reach that of gold-standard methods such as enzyme-linked immunosorbent assays, the operational convenience of the sensor platform enables exciting analytical applications that we address. Using illustrative examples, we highlight recent advances in the field that impact important areas of analytical chemistry. Finally, we discuss the challenges and prospects for this class of sensors.

  3. Reagentless, Structure-Switching, Electrochemical Aptamer-Based Sensors

    Science.gov (United States)

    Schoukroun-Barnes, Lauren R.; Macazo, Florika C.; Gutierrez, Brenda; Lottermoser, Justine; Liu, Juan; White, Ryan J.

    2016-06-01

    The development of structure-switching, electrochemical, aptamer-based sensors over the past ˜10 years has led to a variety of reagentless sensors capable of analytical detection in a range of sample matrices. The crux of this methodology is the coupling of target-induced conformation changes of a redox-labeled aptamer with electrochemical detection of the resulting altered charge transfer rate between the redox molecule and electrode surface. Using aptamer recognition expands the highly sensitive detection ability of electrochemistry to a range of previously inaccessible analytes. In this review, we focus on the methods of sensor fabrication and how sensor signaling is affected by fabrication parameters. We then discuss recent studies addressing the fundamentals of sensor signaling as well as quantitative characterization of the analytical performance of electrochemical aptamer-based sensors. Although the limits of detection of reported electrochemical aptamer-based sensors do not often reach that of gold-standard methods such as enzyme-linked immunosorbent assays, the operational convenience of the sensor platform enables exciting analytical applications that we address. Using illustrative examples, we highlight recent advances in the field that impact important areas of analytical chemistry. Finally, we discuss the challenges and prospects for this class of sensors.

  4. Fluorescent sensors based on bacterial fusion proteins

    Science.gov (United States)

    Prats Mateu, Batirtze; Kainz, Birgit; Pum, Dietmar; Sleytr, Uwe B.; Toca-Herrera, José L.

    2014-06-01

    Fluorescence proteins are widely used as markers for biomedical and technological purposes. Therefore, the aim of this project was to create a fluorescent sensor, based in the green and cyan fluorescent protein, using bacterial S-layers proteins as scaffold for the fluorescent tag. We report the cloning, expression and purification of three S-layer fluorescent proteins: SgsE-EGFP, SgsE-ECFP and SgsE-13aa-ECFP, this last containing a 13-amino acid rigid linker. The pH dependence of the fluorescence intensity of the S-layer fusion proteins, monitored by fluorescence spectroscopy, showed that the ECFP tag was more stable than EGFP. Furthermore, the fluorescent fusion proteins were reassembled on silica particles modified with cationic and anionic polyelectrolytes. Zeta potential measurements confirmed the particle coatings and indicated their colloidal stability. Flow cytometry and fluorescence microscopy showed that the fluorescence of the fusion proteins was pH dependent and sensitive to the underlying polyelectrolyte coating. This might suggest that the fluorescent tag is not completely exposed to the bulk media as an independent moiety. Finally, it was found out that viscosity enhanced the fluorescence intensity of the three fluorescent S-layer proteins.

  5. A wearable sensor based on CLYC scintillators

    Science.gov (United States)

    McDonald, Benjamin S.; Myjak, Mitchell J.; Zalavadia, Mital A.; Smart, John E.; Willett, Jesse A.; Landgren, Peter C.; Greulich, Christopher R.

    2016-06-01

    We have developed a wearable radiation sensor using Cs2LiYCl6:Ce (CLYC) for simultaneous gamma-ray and neutron detection. The system includes two ∅ 2.5 × 2.5cm3 crystals coupled to small, metal-body photomultiplier tubes. A custom, low-power electronics base digitizes the output signal at three time points and enables both pulse height and pulse shape discrimination of gamma rays and neutrons. The total counts, anomaly detection metrics, and identified isotopes are displayed on a small screen. Users may leave the device in unattended mode to collect long-dwell energy spectra. The system stores up to 18 h of one-second data, including energy spectra, and may transfer the data to a remote computer via a wired or wireless connection. The prototype is 18 × 13 × 7.5cm3, weighs 1.3 kg, not including the protective pouch, and runs on six AA alkaline batteries for 29 h with the wireless link active, or 41 h with the wireless link disabled. In this paper, we summarize the system design and present characterization results from the detector modules. The energy resolution is about 6.5% full width at half maximum at 662 keV due to the small photomultiplier tube selected, and the linearity and pulse shape discrimination performance are very good.

  6. A wearable sensor based on CLYC scintillators

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, Benjamin S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Myjak, Mitchell J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zalavadia, Mital A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Smart, John E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Willett, Jesse A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Landgren, Peter C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Greulich, Christopher R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-06-01

    We developed a wearable radiation sensor using Cs2LiYCl6:Ce (CLYC) for simultaneous gamma-ray and neutron detection. The system includes two ø2.5×2.5 cm3 crystals coupled to small, metal-body photomultiplier tubes. A custom, low-power electronics base digitizes the output signal at three time points and enables both pulse height and pulse shape discrimination of neutrons and gamma-rays. Data, including spectra, can be transferred via a wired or wireless connection. The total gamma-ray and neutron counts, anomaly detection metrics, and identified isotopes are displayed on a small screen on the device. Users may leave the system in unattended mode to collect long-dwell energy spectra. The prototype system has overall dimensions of 13×7.5×18 cm3 and weight of 1.3 kg, not including the protective pouch, and runs on six AA alkaline batteries for 29 hours with a 1% wireless transmission duty cycle and 41 hours with the wireless turned off . In this paper, we summarize the system design and present characterization results from the detector modules. The energy resolution is about 6.5% full width at half maximum at 662 keV due to the small photomultiplier tube selected, and the linearity and pulse shape discrimination performance are very good.

  7. Gum Sensor: A Stretchable, Wearable, and Foldable Sensor Based on Carbon Nanotube/Chewing Gum Membrane.

    Science.gov (United States)

    Darabi, Mohammad Ali; Khosrozadeh, Ali; Wang, Quan; Xing, Malcolm

    2015-12-02

    Presented in this work is a novel and facile approach to fabricate an elastic, attachable, and cost-efficient carbon nanotube (CNT)-based strain gauge which can be efficiently used as bodily motion sensors. An innovative and unique method is introduced to align CNTs without external excitations or any complicated procedure. In this design, CNTs are aligned and distributed uniformly on the entire chewing gum by multiple stretching and folding technique. The current sensor is demonstrated to be a linear strain sensor for at least strains up to 200% and can detect strains as high as 530% with a high sensitivity ranging from 12 to 25 and high durability. The gum sensor has been used as bodily motion sensors, and outstanding results are achieved; the sensitivity is quite high, capable of tracing slow breathing. Since the gum sensor can be patterned into various forms, it has wide applications in miniaturized sensors and biochips. Interestingly, we revealed that our gum sensor has the ability to monitor humidity changes with high sensitivity and fast resistance response capable of monitoring human breathing.

  8. Development of sensor system for indoor location based service implementation

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Joo Heon; Lee, Kyung Ho [Kookmin Univ., Seoul (Korea, Republic of)

    2012-11-15

    This paper introduces a sensor system based on indoor locations in order to implement the Building Energy Management System. This system consists of a thermopile sensor and an ultrasonic sensor. The sensor module is rotated by 360 .deg. and yawed up and down by two electric motors. Therefore, it can simultaneously detect the number and location of the inhabitants in the room. It uses wireless technology to communicate with the building manager or the smart home server, and it can save electric energy by controlling the lighting system or heating/air conditioning equipment automatically. We also demonstrate the usefulness of the proposed system by applying it to a real environment.

  9. A simple optical fiber interferometer based breathing sensor

    Science.gov (United States)

    Li, Xixi; Liu, Dejun; Kumar, Rahul; Ng, Wai Pang; Fu, Yong-qing; Yuan, Jinhui; Yu, Chongxiu; Wu, Yufeng; Zhou, Guorui; Farrell, Gerald; Semenova, Yuliya; Wu, Qiang

    2017-03-01

    A breathing sensor has been experimentally demonstrated based on a singlemode–multimode–singlemode (SMS) fiber structure which is attached to a thin plastic film in an oxygen mask. By detecting power variations due to the macro bending applied to the SMS section by each inhalation and exhalation process, the breath state can be monitored. The proposed sensor is capable of distinguishing different types of breathing conditions including regular and irregular breath state. The sensor can be used in a strong electric/magnetic field and radioactive testing systems such as magnetic resonance imaging (MRI) systems and computed tomography (CT) examinations where electrical sensors are restricted.

  10. Biomimetic virus-based colourimetric sensors

    Science.gov (United States)

    Oh, Jin-Woo; Chung, Woo-Jae; Heo, Kwang; Jin, Hyo-Eon; Lee, Byung Yang; Wang, Eddie; Zueger, Chris; Wong, Winnie; Meyer, Joel; Kim, Chuntae; Lee, So-Young; Kim, Won-Geun; Zemla, Marcin; Auer, Manfred; Hexemer, Alexander; Lee, Seung-Wuk

    2014-01-01

    Many materials in nature change colours in response to stimuli, making them attractive for use as sensor platform. However, both natural materials and their synthetic analogues lack selectivity towards specific chemicals, and introducing such selectivity remains a challenge. Here we report the self-assembly of genetically engineered viruses (M13 phage) into target-specific, colourimetric biosensors. The sensors are composed of phage-bundle nanostructures and exhibit viewing-angle independent colour, similar to collagen structures in turkey skin. On exposure to various volatile organic chemicals, the structures rapidly swell and undergo distinct colour changes. Furthermore, sensors composed of phage displaying trinitrotoluene (TNT)-binding peptide motifs identified from a phage display selectively distinguish TNT down to 300 p.p.b. over similarly structured chemicals. Our tunable, colourimetric sensors can be useful for the detection of a variety of harmful toxicants and pathogens to protect human health and national security.

  11. Biomimic Hairy Skin Tactile Sensor Based on Ferromagnetic Microwires.

    Science.gov (United States)

    Zhang, Jian; Hao, Lifeng; Yang, Fan; Jiao, Weicheng; Liu, Wenbo; Li, Yibin; Wang, Rongguo; He, Xiaodong

    2016-12-14

    We present a multifunctional tactile sensor inspired by human hairy skin structure, in which the sensitive hair sensor and the robust skin sensor are integrated into a single device via a pair of Co-based ferromagnetic microwire arrays in a very simple manner. The sensor possesses a self-tunable effective compliance with respect to the magnitude of the stimulus, allowing a wide range of loading force to be measured. The sensor also exhibits some amazing functions, such as air-flow detection, material property characterization, and excellent damage resistance. The novel sensing mechanism and structure provide a new strategy for designing multifunctional tactile sensors and show great potential applications on intelligent robot and sensing in harsh environments.

  12. Parallel Microcracks-based Ultrasensitive and Highly Stretchable Strain Sensors.

    Science.gov (United States)

    Amjadi, Morteza; Turan, Mehmet; Clementson, Cameron P; Sitti, Metin

    2016-03-01

    There is an increasing demand for flexible, skin-attachable, and wearable strain sensors due to their various potential applications. However, achieving strain sensors with both high sensitivity and high stretchability is still a grand challenge. Here, we propose highly sensitive and stretchable strain sensors based on the reversible microcrack formation in composite thin films. Controllable parallel microcracks are generated in graphite thin films coated on elastomer films. Sensors made of graphite thin films with short microcracks possess high gauge factors (maximum value of 522.6) and stretchability (ε ≥ 50%), whereas sensors with long microcracks show ultrahigh sensitivity (maximum value of 11,344) with limited stretchability (ε ≤ 50%). We demonstrate the high performance strain sensing of our sensors in both small and large strain sensing applications such as human physiological activity recognition, human body large motion capturing, vibration detection, pressure sensing, and soft robotics.

  13. A carbon nanotube based ammonia sensor on cotton textile

    Science.gov (United States)

    Han, Jin-Woo; Kim, Beomseok; Li, Jing; Meyyappan, M.

    2013-05-01

    A single-wall carbon nanotube (CNT) based ammonia (NH3) sensor was implemented on a cotton yarn. Two types of sensors were fabricated: Au/sensing CNT/Au and conducting/sensing/conducting all CNT structures. Two perpendicular Au wires were designed to contact CNT-cotton yarn for metal-CNT sensor, whereas nanotubes were used for the electrode as well as sensing material for the all CNT sensor. The resistance shift of the CNT network upon NH3 was monitored in a chemiresistor approach. The CNT-cotton yarn sensors exhibited uniformity and repeatability. Furthermore, the sensors displayed good mechanical robustness against bending. The present approach can be utilized for low-cost smart textile applications.

  14. Optimization of Surface Acoustic Wave-Based Rate Sensors

    Directory of Open Access Journals (Sweden)

    Fangqian Xu

    2015-10-01

    Full Text Available The optimization of an surface acoustic wave (SAW-based rate sensor incorporating metallic dot arrays was performed by using the approach of partial-wave analysis in layered media. The optimal sensor chip designs, including the material choice of piezoelectric crystals and metallic dots, dot thickness, and sensor operation frequency were determined theoretically. The theoretical predictions were confirmed experimentally by using the developed SAW sensor composed of differential delay line-oscillators and a metallic dot array deposited along the acoustic wave propagation path of the SAW delay lines. A significant improvement in sensor sensitivity was achieved in the case of 128° YX LiNbO3, and a thicker Au dot array, and low operation frequency were used to structure the sensor.

  15. Virtual speed sensors based algorithm for expressway traffic state estimation

    Institute of Scientific and Technical Information of China (English)

    XU DongWei; DONG HongHui; JIA LiMin; QIN Yong

    2012-01-01

    The accurate estimation of expressway traffic state can provide decision-making for both travelers and traffic managers.The speed is one of the most representative parameter of the traffic state.So the expressway speed spatial distribution can be taken as the expressway traffic state equivalent.In this paper,an algorithm based on virtual speed sensors (VSS) is presented to estimate the expressway traffic state (the speed spatial distribution).To gain the spatial distribution of expressway traffic state,virtual speed sensors are defined between adjacent traffic flow sensors.Then,the speed data extracted from traffic flow sensors in time series are mapped to space series to design virtual speed sensors.Then the speed of virtual speed sensors can be calculated with the weight matrix which is related with the speed of virtual speed sensors and the speed data extracted from traffic flow sensors and the speed data extracted from traffic flow sensors in time series.Finally,the expressway traffic state (the speed spatial distribution) can be gained.The acquisition of average travel speed of the expressway is taken for application of this traffic state estimation algorithm.One typical expressway in Beijing is adopted for the experiment analysis.The results prove that this traffic state estimation approach based on VSS is feasible and can achieve a high accuracy.

  16. Combine harvester monitor system based on wireless sensor network

    Science.gov (United States)

    A measurement method based on Wireless Sensor Network (WSN) was developed to monitor the working condition of combine harvester for remote application. Three JN5139 modules were chosen for sensor data acquisition and another two as a router and a coordinator, which could create a tree topology netwo...

  17. In plane optical sensor based on organic electronic devices

    NARCIS (Netherlands)

    Koetse, M.M; Rensing, P.A.; Heck, G.T. van; Sharpe, R.B.A.; Allard, B.A.M.; Wieringa, F.P.; Kruijt, P.G.M.; Meulendijks, N.M.M.; Jansen, H.; Schoo, H.F.M.

    2008-01-01

    Sensors based on organic electronic devices are emerging in a wide range of application areas. Here we present a sensor platform using organic light emitting diodes (OLED) and organic photodiodes (OPD) as active components. By means of lamination and interconnection technology the functional foils w

  18. Foil-based optical technology platform for optochemical sensors

    NARCIS (Netherlands)

    Kalathimekkad, S.; Missinne, J.; Arias Espinoza, J.D.; Hoe, B. van; Bosman, E.; Smits, E.; Mandamparambil, R.; Steenberge, G. van; Vanfleteren, J.

    2012-01-01

    This paper describes the development of a low-cost technology platform for fluorescence-based optochemical sensors. These sensors were constructed by incorporating fluorescent sensing elements in the core of multimode waveguides or lightguides, and have applications in medical, biochemical and envir

  19. A capacitive RF power sensor based on MEMS technology

    NARCIS (Netherlands)

    Fernandez, Luis Jose

    2005-01-01

    Existing power sensors for RF signals are based on thermistors, diodes and thermocouples. These power sensors are used as terminating devices and therefore they dissipate the complete incoming signal. Furthermore, new telecommunication systems require low weight, volume and power consumption and a h

  20. Novel Membrane-Based Electrochemical Sensor for Real-Time Bio-Applications

    Directory of Open Access Journals (Sweden)

    Fatima AlZahra'a Alatraktchi

    2014-11-01

    Full Text Available This article presents a novel membrane-based sensor for real-time electrochemical investigations of cellular- or tissue cultures. The membrane sensor enables recording of electrical signals from a cell culture without any signal dilution, thus avoiding loss of sensitivity. Moreover, the porosity of the membrane provides optimal culturing conditions similar to existing culturing techniques allowing more efficient nutrient uptake and molecule release. The patterned sensor electrodes were fabricated on a porous membrane by electron-beam evaporation. The electrochemical performance of the membrane electrodes was characterized by cyclic voltammetry and chronoamperometry, and the detection of synthetic dopamine was demonstrated down to a concentration of 3.1 pM. Furthermore, to present the membrane-sensor functionality the dopamine release from cultured PC12 cells was successfully measured. The PC12 cells culturing experiments showed that the membrane-sensor was suitable as a cell culturing substrate for bio-applications. Real-time measurements of dopamine exocytosis in cell cultures were performed, where the transmitter release was recorded at the point of release. The developed membrane-sensor provides a new functionality to the standard culturing methods, enabling sensitive continuous in vitro monitoring and closely mimicking the in vivo conditions.

  1. Submersible microbial fuel cell sensor for monitoring microbial activity and BOD in groundwater: focusing on impact of anodic biofilm on sensor applicability.

    Science.gov (United States)

    Zhang, Yifeng; Angelidaki, Irini

    2011-10-01

    A sensor, based on a submersible microbial fuel cell (SUMFC), was developed for in situ monitoring of microbial activity and biochemical oxygen demand (BOD) in groundwater. Presence or absence of a biofilm on the anode was a decisive factor for the applicability of the sensor. Fresh anode was required for application of the sensor for microbial activity measurement, while biofilm-colonized anode was needed for utilizing the sensor for BOD content measurement. The current density of SUMFC sensor equipped with a biofilm-colonized anode showed linear relationship with BOD content, to up to 250 mg/L (∼233 ± 1 mA/m(2)), with a response time of BOD was observed. It was found that temperature, pH, conductivity, and inorganic solid content were significantly affecting the sensitivity of the sensor. Lastly, the sensor was tested with real contaminated groundwater, where the microbial activity and BOD content could be detected in BOD concentration measured by SUMFC sensor fitted well with the one measured by the standard methods, with deviations ranging from 15% to 22% and 6% to 16%, respectively. The SUMFC sensor provides a new way for in situ and quantitative monitoring contaminants content and biological activity during bioremediation process in variety of anoxic aquifers.

  2. A novel pH optical sensor using methyl orange based on triacetylcellulose membranes as support.

    Science.gov (United States)

    Hosseini, Mohammad; Heydari, Rouhollah; Alimoradi, Mohammad

    2014-07-15

    A novel pH optical sensor based on triacetylcellulose membrane as solid support was developed by using immobilization of methyl orange indicator. The prepared optical sensor was fixed into a flow cell for on-line pH monitoring. Variables affecting sensor performance, such as pH of dye bonding to triacetylcellulose membrane and dye concentration have been fully evaluated and optimized. The calibration curve showed good behavior and precision (RSD<0.4%) in the pH range of 4.0-12.0. No significant variation was observed on sensor response with increasing the ionic strength in the range of 0.0-0.5M of sodium chloride. Determination of pH by using the proposed optical sensor is on-line, quick, inexpensive, selective and sensitive in the pH range of 4.0-12.0.

  3. Raman microspectroscopy based sensor of algal lipid unsaturation

    Science.gov (United States)

    Samek, Ota; Pilát, Zdeněk; Jonáš, Alexandr; Zemánek, Pavel; Šerý, Mojmír; Ježek, Jan; Bernatová, Silvie; Nedbal, Ladislav; Trtílek, Martin

    2011-05-01

    Raman spectroscopy is a powerful tool for chemical analysis. This technique can elucidate fundamental questions about the metabolic processes and intercellular variability on a single cell level. Therefore, Raman spectroscopy can significantly contribute to the study and use of microalgae in systems biology and biofuel technology. Raman spectroscopy can be combined with optical tweezers. We have employed microfluidic system to deliver the sampled microalgae to the Raman-tweezers. This instrument is able to measure chemical composition of cells and to track metabolic processes in vivo, in real-time and label-free making it possible to detect population variability in a wide array of traits. Moreover, employing an active sorting switch, cells can be separated depending on input parameters obtained from Raman spectra. We focus on algal lipids which are promising potential products for biofuel as well as for nutrition. Important parameter characterizing the algal lipids is the degree of unsaturation of the constituent fatty acids. We demonstrate the capacity of our Raman tweezers based sensor to sort cells according to the degree of unsaturation in lipid storage bodies of individual living algal cells.

  4. Novel membrane-based electrochemical sensor for real-time bio-applications

    DEFF Research Database (Denmark)

    Al Atraktchi, Fatima Al-Zahraa; Bakmand, Tanya; Dimaki, Maria

    2014-01-01

    This article presents a novel membrane-based sensor for real-time electrochemical investigations of cellular- or tissue cultures. The membrane sensor enables recording of electrical signals from a cell culture without any signal dilution, thus avoiding loss of sensitivity. Moreover, the porosity...... of the membrane provides optimal culturing conditions similar to existing culturing techniques allowing more efficient nutrient uptake and molecule release. The patterned sensor electrodes were fabricated on a porous membrane by electron-beam evaporation. The electrochemical performance of the membrane electrodes...

  5. 基于BIOMEMS技术的细胞电阻抗传感器的研究进展%Research progress of the cell-impedance sensor based on MEMS technique

    Institute of Scientific and Technical Information of China (English)

    徐莹; 杨勇; 王平

    2008-01-01

    细胞一电阻抗传感器是基于BIOMEMS技术的研究细胞电生理和临床药理研究的新兴工具,主要应用于细胞等微生物体的形态和功能研究.近年来,它以其新颖简单的设计和长时程的无损测试等优点一直受到国内外学者和企业的广泛关注.首先分析细胞一电极阻抗界面模型并加以细化,然后介绍生物阻抗传感器在国际上研究的最新进展.在此基础上,结合实验室当前的研究工作,介绍了自制的基于叉指型细胞电阻抗传感器,最后提出了未来主要发展方向.%The cell-impedance substrate sensor,which is mainly used to detect the shapes and function of cells and other micro.organism.is a novel tool based on the technique of BIOMEMS to study the cellular physiology and clinical Dharmasology.It has drawn attention from both domestic and international scholars as well as compa nies in recent years for its advantages such as innovative design and long-term non-invasive monitoring.This paper introduces the interfacial model of cell-sensor in detail and gives a sketch of the recent international research progress.Then the novel interdigitated array,which was designed in our group recently,is introduced.The fore ground of development is discussed in the end.

  6. A Miniaturized Optical Sensor with Integrated Gas Cell

    NARCIS (Netherlands)

    Ayerden, N.P.; Ghaderi, M.; De Graaf, G.; Wolffenbuttel, R.F.

    2015-01-01

    The design, fabrication and characterization of a highly integrated optical gas sensor is presented. The gas cell takes up most of the space in a microspectrometer and is the only component that has so far not been miniaturized. Using the tapered resonator cavity of a linear variable optical filter

  7. Standards-Based Wireless Sensor Networking Protocols for Spaceflight Applications

    Science.gov (United States)

    Wagner, Raymond S.

    2010-01-01

    Wireless sensor networks (WSNs) have the capacity to revolutionize data gathering in both spaceflight and terrestrial applications. WSNs provide a huge advantage over traditional, wired instrumentation since they do not require wiring trunks to connect sensors to a central hub. This allows for easy sensor installation in hard to reach locations, easy expansion of the number of sensors or sensing modalities, and reduction in both system cost and weight. While this technology offers unprecedented flexibility and adaptability, implementing it in practice is not without its difficulties. Recent advances in standards-based WSN protocols for industrial control applications have come a long way to solving many of the challenges facing practical WSN deployments. In this paper, we will overview two of the more promising candidates - WirelessHART from the HART Communication Foundation and ISA100.11a from the International Society of Automation - and present the architecture for a new standards-based sensor node for networking and applications research.

  8. Multipoint sensor based on fiber Bragg gratings

    Energy Technology Data Exchange (ETDEWEB)

    Mendez-Zepeda, O; Munoz-Aguirre, S; Beltran-Perez, G; Castillo-Mixcoatl, J, E-mail: mezeos9@yahoo.com [Facultad de Ciencias FIsico-Matematicas, BUAP Av. San Claudio y Rio Verde, Col. San Manuel, CU. C.P. 72570, Puebla, Puebla (Mexico)

    2011-01-01

    In some control and industrial measurement systems of physical variables (pressure, temperature, flow, etc) it is necessary one system and one sensor to control each process. On the other hand, there are systems such as PLC (Programmable Logic Control), which can process several signals simultaneously. However it is still necessary to use one sensor for each variable. Therefore, in the present work the use of a multipoint sensor to solve such problem has been proposed. The sensor consists of an optical fiber laser with two Fabry-Perot cavities constructed using fiber Bragg gratings (FBG). In the same system is possible to measure changes in two variables by detecting the intermodal separation frequency of each cavity and evaluate their amplitudes. The intermodal separation frequency depends on each cavity length. The sensor signals are monitored through an oscilloscope or a PCI card and after that acquired by PC, where they are analyzed and displayed. Results of the evaluation of the intermodal frequency separation peak amplitude behavior with FBG stretching are presented.

  9. M13 Bacteriophage Based Protein Sensors

    Science.gov (United States)

    Lee, Ju Hun

    Despite significant progress in biotechnology and biosensing, early detection and disease diagnosis remains a critical issue for improving patient survival rates and well-being. Many of the typical detection schemes currently used possess issues such as low sensitivity and accuracy and are also time consuming to run and expensive. In addition, multiplexed detection remains difficult to achieve. Therefore, developing advanced approaches for reliable, simple, quantitative analysis of multiple markers in solution that also are highly sensitive are still in demand. In recent years, much of the research has primarily focused on improving two key components of biosensors: the bio-recognition agent (bio-receptor) and the transducer. Particular bio-receptors that have been used include antibodies, aptamers, molecular imprinted polymers, and small affinity peptides. In terms of transducing agents, nanomaterials have been considered as attractive candidates due to their inherent nanoscale size, durability and unique chemical and physical properties. The key focus of this thesis is the design of a protein detection and identification system that is based on chemically engineered M13 bacteriophage coupled with nanomaterials. The first chapter provides an introduction of biosensors and M13 bacteriophage in general, where the advantages of each are provided. In chapter 2, an efficient and enzyme-free sensor is demonstrated from modified M13 bacteriophage to generate highly sensitive colorimetric signals from gold nanocrystals. In chapter 3, DNA conjugated M13 were used to enable facile and rapid detection of antigens in solution that also provides modalities for identification. Lastly, high DNA loadings per phage was achieved via hydrozone chemistry and these were applied in conjunction with Raman active DNA-gold/silver core/shell nanoparticles toward highly sensitive SERS sensing.

  10. A Respiration Sensor for a Chest-Strap Based Wireless Body Sensor

    OpenAIRE

    2014-01-01

    In this paper we present a respiration sensor suitable for an integration into a wireless body sensor worn around the chest. The thorax expansion and contraction during in- and exhalation is captured using a force-sensing resistor. Based on the captured thoracic movements, the breaths are determined with a peak detection algorithm. For evaluation, a treadmill experiment with five subjects was conducted using an ergospirometry system as a reference. Overall, an average deviation of -0.32±0.68 ...

  11. Sensor selection for received signal strength-based source localization in wireless sensor networks

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Generally, localization is a nonlinear problem, while linearization is used to simplify this problem. Reasonable approximations could be achieved when signal-to-noise ratio (SNR) is large enough. Energy is a critical resource in wireless sensor networks, and system lifetime needs to be prolonged through the use of energy efficient strategies during system operation. In this paper, a closed-form solution for received signal strength (RSS)-based source localization in wireless sensor network (WSN) is obtained...

  12. Textile-based weft knitted strain sensors: effect of fabric parameters on sensor properties.

    Science.gov (United States)

    Atalay, Ozgur; Kennon, William Richard; Husain, Muhammad Dawood

    2013-08-21

    The design and development of textile-based strain sensors has been a focus of research and many investigators have studied this subject. This paper presents a new textile-based strain sensor design and shows the effect of base fabric parameters on its sensing properties. Sensing fabric could be used to measure articulations of the human body in the real environment. The strain sensing fabric was produced by using electronic flat-bed knitting technology; the base fabric was produced with elastomeric yarns in an interlock arrangement and a conductive yarn was embedded in this substrate to create a series of single loop structures. Experimental results show that there is a strong relationship between base fabric parameters and sensor properties.

  13. Textile-Based Weft Knitted Strain Sensors: Effect of Fabric Parameters on Sensor Properties

    Directory of Open Access Journals (Sweden)

    William Richard Kennon

    2013-08-01

    Full Text Available The design and development of textile-based strain sensors has been a focus of research and many investigators have studied this subject. This paper presents a new textile-based strain sensor design and shows the effect of base fabric parameters on its sensing properties. Sensing fabric could be used to measure articulations of the human body in the real environment. The strain sensing fabric was produced by using electronic flat-bed knitting technology; the base fabric was produced with elastomeric yarns in an interlock arrangement and a conductive yarn was embedded in this substrate to create a series of single loop structures. Experimental results show that there is a strong relationship between base fabric parameters and sensor properties.

  14. Development of ERK Activity Sensor, an in vitro, FRET-based sensor of Extracellular Regulated Kinase activity

    Directory of Open Access Journals (Sweden)

    Alberola-Ila José

    2005-07-01

    Full Text Available Abstract Background Study of ERK activation has thus far relied on biochemical assays that are limited to the use of phospho-specific antibodies and radioactivity in vitro, and analysis of whole cell populations in vivo. As with many systems, fluorescence resonance energy transfer (FRET can be utilized to make highly sensitive detectors of molecular activity. Here we introduce FRET-based ERK Activity Sensors, which utilize variants of Enhanced Green Fluorescent Protein fused by an ERK-specific peptide linker to detect ERK2 activity. Results ERK Activity Sensors display varying changes in FRET upon phosphorylation by active ERK2 in vitro depending on the composition of ERK-specific peptide linker sequences derived from known in vivo ERK targets, Ets1 and Elk1. Analysis of point mutations reveals specific residues involved in ERK binding and phosphorylation of ERK Activity Sensor 3. ERK2 also shows high in vitro specificity for these sensors over two other major MAP Kinases, p38 and pSAPK/JNK. Conclusion EAS's are a convenient, non-radioactive alternative to study ERK dynamics in vitro. They can be utilized to study ERK activity in real-time. This new technology can be applied to studying ERK kinetics in vitro, analysis of ERK activity in whole cell extracts, and high-throughput screening technologies.

  15. Capillarity-based preparation system for optical colorimetric sensor arrays.

    Science.gov (United States)

    Luo, Xiao-Gang; Yi, Xin; Bu, Xiang-Nan; Hou, Chang-Jun; Huo, Dan-Qun; Yang, Mei; Fa, Huan-Bao; Lei, Jin-Can

    2017-03-01

    In recent years, optical colorimetric sensor arrays have demonstrated beneficial features, including rapid response, high selectivity, and high specificity; as a result, it has been extensively applied in food inspection and chemical studies, among other fields. There are instruments in the current market available for the preparation of an optical colorimetric sensor array, but it lacks the corresponding research of the preparation mechanism. Therefore, in connection with the main features of this kind of sensor array such as consistency, based on the preparation method of contact spotting, combined with a capillary fluid model, Washburn equation, Laplace equation, etc., this paper develops a diffusion model of an optical colorimetric sensor array during its preparation and sets up an optical colorimetric sensor array preparation system based on this diffusion model. Finally, this paper compares and evaluates the sensor arrays prepared by the system and prepared manually in three aspects such as the quality of array point, response of array, and response result, and the results show that the performance index of the sensor array prepared by a system under this diffusion model is better than that of the sensor array of manual spotting, which meets the needs of the experiment.

  16. Capillarity-based preparation system for optical colorimetric sensor arrays

    Science.gov (United States)

    Luo, Xiao-gang; Yi, Xin; Bu, Xiang-nan; Hou, Chang-jun; Huo, Dan-qun; Yang, Mei; Fa, Huan-bao; Lei, Jin-can

    2017-03-01

    In recent years, optical colorimetric sensor arrays have demonstrated beneficial features, including rapid response, high selectivity, and high specificity; as a result, it has been extensively applied in food inspection and chemical studies, among other fields. There are instruments in the current market available for the preparation of an optical colorimetric sensor array, but it lacks the corresponding research of the preparation mechanism. Therefore, in connection with the main features of this kind of sensor array such as consistency, based on the preparation method of contact spotting, combined with a capillary fluid model, Washburn equation, Laplace equation, etc., this paper develops a diffusion model of an optical colorimetric sensor array during its preparation and sets up an optical colorimetric sensor array preparation system based on this diffusion model. Finally, this paper compares and evaluates the sensor arrays prepared by the system and prepared manually in three aspects such as the quality of array point, response of array, and response result, and the results show that the performance index of the sensor array prepared by a system under this diffusion model is better than that of the sensor array of manual spotting, which meets the needs of the experiment.

  17. Sensor Fusion Based Model for Collision Free Mobile Robot Navigation

    Directory of Open Access Journals (Sweden)

    Marwah Almasri

    2015-12-01

    Full Text Available Autonomous mobile robots have become a very popular and interesting topic in the last decade. Each of them are equipped with various types of sensors such as GPS, camera, infrared and ultrasonic sensors. These sensors are used to observe the surrounding environment. However, these sensors sometimes fail and have inaccurate readings. Therefore, the integration of sensor fusion will help to solve this dilemma and enhance the overall performance. This paper presents a collision free mobile robot navigation based on the fuzzy logic fusion model. Eight distance sensors and a range finder camera are used for the collision avoidance approach where three ground sensors are used for the line or path following approach. The fuzzy system is composed of nine inputs which are the eight distance sensors and the camera, two outputs which are the left and right velocities of the mobile robot’s wheels, and 24 fuzzy rules for the robot’s movement. Webots Pro simulator is used for modeling the environment and the robot. The proposed methodology, which includes the collision avoidance based on fuzzy logic fusion model and line following robot, has been implemented and tested through simulation and real time experiments. Various scenarios have been presented with static and dynamic obstacles using one robot and two robots while avoiding obstacles in different shapes and sizes.

  18. Sensor Fusion Based Model for Collision Free Mobile Robot Navigation.

    Science.gov (United States)

    Almasri, Marwah; Elleithy, Khaled; Alajlan, Abrar

    2015-12-26

    Autonomous mobile robots have become a very popular and interesting topic in the last decade. Each of them are equipped with various types of sensors such as GPS, camera, infrared and ultrasonic sensors. These sensors are used to observe the surrounding environment. However, these sensors sometimes fail and have inaccurate readings. Therefore, the integration of sensor fusion will help to solve this dilemma and enhance the overall performance. This paper presents a collision free mobile robot navigation based on the fuzzy logic fusion model. Eight distance sensors and a range finder camera are used for the collision avoidance approach where three ground sensors are used for the line or path following approach. The fuzzy system is composed of nine inputs which are the eight distance sensors and the camera, two outputs which are the left and right velocities of the mobile robot's wheels, and 24 fuzzy rules for the robot's movement. Webots Pro simulator is used for modeling the environment and the robot. The proposed methodology, which includes the collision avoidance based on fuzzy logic fusion model and line following robot, has been implemented and tested through simulation and real time experiments. Various scenarios have been presented with static and dynamic obstacles using one robot and two robots while avoiding obstacles in different shapes and sizes.

  19. Micro-Vibration-Based Slip Detection in Tactile Force Sensors

    Directory of Open Access Journals (Sweden)

    Raul Fernandez

    2014-01-01

    Full Text Available Tactile sensing provides critical information, such as force, texture, shape or temperature, in manipulation tasks. In particular, tactile sensors traditionally used in robotics are emphasized in contact force determination for grasping control and object recognition. Nevertheless, slip detection is also crucial to successfully manipulate an object. Several approaches have appeared to detect slipping, the majority being a combination of complex sensors with complex algorithms. In this paper, we deal with simplicity, analyzing how a novel, but simple, algorithm, based on micro-vibration detection, can be used in a simple, but low-cost and durable, force sensor. We also analyze the results of using the same principle to detect slipping in other force sensors based on flexible parts. In particular, we show and compare the slip detection with: (i a flexible finger, designed by the authors, acting as a force sensor; (ii the finger torque sensor of a commercial robotic hand; (iii a commercial six-axis force sensor mounted on the wrist of a robot; and (iv a fingertip piezoresistive matrix sensor.

  20. Micro-vibration-based slip detection in tactile force sensors.

    Science.gov (United States)

    Fernandez, Raul; Payo, Ismael; Vazquez, Andres S; Becedas, Jonathan

    2014-01-03

    Tactile sensing provides critical information, such as force, texture, shape or temperature, in manipulation tasks. In particular, tactile sensors traditionally used in robotics are emphasized in contact force determination for grasping control and object recognition. Nevertheless, slip detection is also crucial to successfully manipulate an object. Several approaches have appeared to detect slipping, the majority being a combination of complex sensors with complex algorithms. In this paper, we deal with simplicity, analyzing how a novel, but simple, algorithm, based on micro-vibration detection, can be used in a simple, but low-cost and durable, force sensor. We also analyze the results of using the same principle to detect slipping in other force sensors based on flexible parts. In particular, we show and compare the slip detection with: (i) a flexible finger, designed by the authors, acting as a force sensor; (ii) the finger torque sensor of a commercial robotic hand; (iii) a commercial six-axis force sensor mounted on the wrist of a robot; and (iv) a fingertip piezoresistive matrix sensor.

  1. A versatile integrating sphere based photoacoustic sensor for trace gas monitoring

    CERN Document Server

    Lassen, Mikael; Brusch, Anders; Petersen, Jan C

    2014-01-01

    A compact versatile photoacoustic (PA) sensor for trace gas detection is reported. The sensor is based on an integrating sphere as the PA absorption cell with an organ pipe tube attached to increase the sensitivity of the PA sensor. The versatility and enhancement of the sensitivity of the PA signal is investigated by monitoring specific ro-vibrational lines of CO2 in the 2 mm wavelength region and of NO2 in the 405 nm region. The measured enhancement factor of the PA signal exceeds 1200, which is due to the acoustic resonance of the tube and the absorption enhancement of the integrating sphere relatively to a non-resonant single pass cell. It is observed that the background absorption signals are highly attenuated due to the thermal conduction and diffusion effects in the polytetrafluoroethylene cell walls. This demonstrates that careful choice of cell wall materials can be highly beneficial to the sensitivity of the PA sensor. These properties makes the sensor suitable for various practical sensor applicati...

  2. Ultrasensitive photoacoustic sensor based on quantum cascade laser spectroscopy

    Science.gov (United States)

    Kumar, Deepak; Gautam, Surya; Kumar, Subodh; Gupta, Saurabh; Srivastava, Hari B.; Thakur, Surya N.; Sharma, Ramesh C.

    2017-04-01

    The paper focuses on development of ultra-sonic detection system based on laser photoacoustic spectroscopic technique and processing of signal for detection of very low quantity chemicals, explosive materials, and mixtures of these hazardous molecules. The detection system has been developed for the first time with specially designed one side open photo-acoustic cell having high quality factor. Explosive and Hazardous materials like RDX, DNT, PETN, Gun Powder, TATP (Tri acetone tri-peroxide) and their simulants like Acetone were detected in 7 to 9 μm wavelength band. Lock in amplifier electronic instrument was used for the detection of hazardous chemicals and mixture of explosives in very low quantity. Detection limit of the photoacoustic ultrasonic sensor was also carried out of powder, liquid and adsorbed on surfaces.

  3. Portable Nanoparticle-Based Sensors for Food Safety Assessment.

    Science.gov (United States)

    Bülbül, Gonca; Hayat, Akhtar; Andreescu, Silvana

    2015-12-05

    The use of nanotechnology-derived products in the development of sensors and analytical measurement methodologies has increased significantly over the past decade. Nano-based sensing approaches include the use of nanoparticles (NPs) and nanostructures to enhance sensitivity and selectivity, design new detection schemes, improve sample preparation and increase portability. This review summarizes recent advancements in the design and development of NP-based sensors for assessing food safety. The most common types of NPs used to fabricate sensors for detection of food contaminants are discussed. Selected examples of NP-based detection schemes with colorimetric and electrochemical detection are provided with focus on sensors for the detection of chemical and biological contaminants including pesticides, heavy metals, bacterial pathogens and natural toxins. Current trends in the development of low-cost portable NP-based technology for rapid assessment of food safety as well as challenges for practical implementation and future research directions are discussed.

  4. Semiconductor Nanomembrane based Flight Sensors and Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA Phase I program would develop and demonstrate semiconductor nanomembrane (NM) based flight sensors and arrays on flexible substrates, using SOI (Silicon on...

  5. Characterization of optical strain sensors based on silicon waveguides

    NARCIS (Netherlands)

    Westerveld, W.J.; Pozo Torres, J.M.; Muilwijk, P.M.; Leinders, S.M.; Harmsma, P.J.; Tabak, E.; Dool, T.C. van den; Dongen, K.W.A. van; Yousefi, M.; Urbach, H.P.

    2013-01-01

    Strain gauges are widely employed in microelectromechanical systems (MEMS) for sensing of, for example, deformation, acceleration, pressure, or sound [1]. Such gauges are typically based on electronic piezoresistivity. We propose integrated optical sensors which have particular benefits: insensitivi

  6. Intensity based sensor based on single mode optical fiber patchcords

    Science.gov (United States)

    Bayuwati, Dwi; Waluyo, Tomi Budi; Mulyanto, Imam

    2016-11-01

    This paper describes the use of several single mode (SM) fiber patchcords available commercially in the market for intensity based sensor by taking the benefit of bending loss phenomenon. Firtsly, the full transmission spectrum of all fiber patchcords were measured and analyzed to examine its bending properties at a series of wavelength using white light source and optical spectrum analyzer. Bending spectral at various bending diameter using single wavelength light sources were then measured for demonstration.Three good candidates for the intensity based sensor are SM600 fiber patchcord with 970 nm LED, SMF28 fiber patchcord with 1050 nm LED and 780HP fiber patchcord with 1310 nm LED which have noticeable bending sensitive area. Experiments show that the combination of the SMF28with 1050 nm LED has 30 mm measurement range which is the widest; with sensitivity 0.107 dB/mm and resolution 0.5 mm compared with combination of SM600 patchcord and LED 970 nm which has the best sensitivity (0.891 dB/mm) and resolution (0.06 mm) but smaller range measurement (10 mm). Some suitable applications for each fiber patchcord - light source pair have also been discussed.

  7. Coverage analysis for sensor networks based on Clifford algebra

    Institute of Scientific and Technical Information of China (English)

    XIE WeiXin; CAO WenMing; MENG Shan

    2008-01-01

    The coverage performance is the foundation of information acquisition in distrib-uted sensor networks. The previously proposed coverage work was mostly based on unit disk coverage model or ball coverage model in 2D or 3D space, respectively. However, most methods cannot give a homogeneous coverage model for targets with hybrid types. This paper presents a coverage analysis approach for sensor networks based on Clifford algebra and establishes a homogeneous coverage model for sensor networks with hybrid types of targets. The effectiveness of the approach is demonstrated with examples.

  8. Planar Laser-Based QEPAS Trace Gas Sensor

    Directory of Open Access Journals (Sweden)

    Yufei Ma

    2016-06-01

    Full Text Available A novel quartz enhanced photoacoustic spectroscopy (QEPAS trace gas detection scheme is reported in this paper. A cylindrical lens was employed for near-infrared laser focusing. The laser beam was shaped as a planar line laser between the gap of the quartz tuning fork (QTF prongs. Compared with a spherical lens-based QEPAS sensor, the cylindrical lens-based QEPAS sensor has the advantages of easier laser beam alignment and a reduction of stringent stability requirements. Therefore, the reported approach is useful in long-term and continuous sensor operation.

  9. Sensor-based assessment of herbicide effects

    DEFF Research Database (Denmark)

    Streibig, Jens Carl; Rasmussen, Jesper; Andújar, D.;

    2014-01-01

    Non-destructive assessment of herbicide effects may be able to support integrated weed management. To test whether effects of herbicides on canopy variables could be detected by sensors, two crops were used as models and treated with herbicides at BBCH 20 using a logarithmic sprayer. Twelve days...

  10. MIS-based sensors with hydrogen selectivity

    Science.gov (United States)

    Li; ,Dongmei; Medlin, J. William; McDaniel, Anthony H.; Bastasz, Robert J.

    2008-03-11

    The invention provides hydrogen selective metal-insulator-semiconductor sensors which include a layer of hydrogen selective material. The hydrogen selective material can be polyimide layer having a thickness between 200 and 800 nm. Suitable polyimide materials include reaction products of benzophenone tetracarboxylic dianhydride 4,4-oxydianiline m-phenylene diamine and other structurally similar materials.

  11. The impact of MOSFET-based sensors

    NARCIS (Netherlands)

    Bergveld, P.

    1985-01-01

    The basic structure as well as the physical existence of the MOS field-effect transistor is without doubt of great importance for the development of a whole series of sensors for the measurement of physical and chemical environmental parameters. The equation for the MOSFET drain current already sho

  12. Gas Sensors Based on Polymer Field-Effect Transistors.

    Science.gov (United States)

    Lv, Aifeng; Pan, Yong; Chi, Lifeng

    2017-01-22

    This review focuses on polymer field-effect transistor (PFET) based gas sensor with polymer as the sensing layer, which interacts with gas analyte and thus induces the change of source-drain current (ΔISD). Dependent on the sensing layer which can be semiconducting polymer, dielectric layer or conducting polymer gate, the PFET sensors can be subdivided into three types. For each type of sensor, we present the molecular structure of sensing polymer, the gas analyte and the sensing performance. Most importantly, we summarize various analyte-polymer interactions, which help to understand the sensing mechanism in the PFET sensors and can provide possible approaches for the sensor fabrication in the future.

  13. Gas Sensors Based on Polymer Field-Effect Transistors

    Science.gov (United States)

    Lv, Aifeng; Pan, Yong; Chi, Lifeng

    2017-01-01

    This review focuses on polymer field-effect transistor (PFET) based gas sensor with polymer as the sensing layer, which interacts with gas analyte and thus induces the change of source-drain current (ΔISD). Dependent on the sensing layer which can be semiconducting polymer, dielectric layer or conducting polymer gate, the PFET sensors can be subdivided into three types. For each type of sensor, we present the molecular structure of sensing polymer, the gas analyte and the sensing performance. Most importantly, we summarize various analyte–polymer interactions, which help to understand the sensing mechanism in the PFET sensors and can provide possible approaches for the sensor fabrication in the future. PMID:28117760

  14. A Novel Interdigital Capacitor Pressure Sensor Based on LTCC Technology

    Directory of Open Access Journals (Sweden)

    Qiulin Tan

    2014-01-01

    Full Text Available A novel passive wireless pressure sensor is proposed based on LTCC (low temperature cofired ceramic technology. The sensor employs a passive LC circuit, which is composed of a variable interdigital capacitor and a constant inductor. The inductor and capacitor were fabricated by screen-printing. Pressure measurement is tested using a wireless mutual inductance coupling method. The experimental sensitivity of the sensor is about 273.95 kHz/bar below 2 bar. Experimental results show that the sensor can be read out wirelessly by external antenna at 600°C. The max readout distance is 3 cm at room temperature. The sensors described can be applied for monitoring of gas pressure in harsh environments, such as environment with high temperature and chemical corrosion.

  15. Novel electrochemical sensor system for monitoring metabolic activity during the growth and cultivation of prokaryotic and eukaryotic cells.

    Science.gov (United States)

    Pescheck, M; Schrader, J; Sell, D

    2005-09-01

    A novel amperometric sensor system is presented which directly reflects the metabolic activity of prokaryotic and eukaryotic cells during cultivation. The principle of an externally mounted sensor is current measurement using a three-electrode system. Only living cells are detected since the current signal is based on a redox mediator. Added to a culture sample in its oxidized form, the mediator is reduced by cellular metabolism and subsequently re-oxidized at the anode. The spontaneous immobilisation of the cells in the reaction vessel of the sensor by swelling dextrane polymers (Sephadex) prior to measurement is the key to a fast, consistent signal. Even metabolically less active mammalian cells produce a reliable signal within a few minutes; this may open up future applications of the electrochemical sensor in closed loop process control not only for bacterial and fungal bioprocesses, but also in cell culture technology.

  16. Haem-based sensors: a still growing old superfamily.

    Science.gov (United States)

    Germani, Francesca; Moens, Luc; Dewilde, Sylvia

    2013-01-01

    The haem-based sensors are chimeric multi-domain proteins responsible for the cellular adaptive responses to environmental changes. The signal transduction is mediated by the sensing capability of the haem-binding domain, which transmits a usable signal to the cognate transmitter domain, responsible for providing the adequate answer. Four major families of haem-based sensors can be recognized, depending on the nature of the haem-binding domain: (i) the haem-binding PAS domain, (ii) the CO-sensitive carbon monoxide oxidation activator, (iii) the haem NO-binding domain, and (iv) the globin-coupled sensors. The functional classification of the haem-binding sensors is based on the activity of the transmitter domain and, traditionally, comprises: (i) sensors with aerotactic function; (ii) sensors with gene-regulating function; and (iii) sensors with unknown function. We have implemented this classification with newly identified proteins, that is, the Streptomyces avermitilis and Frankia sp. that present a C-terminal-truncated globin fused to an N-terminal cofactor-free monooxygenase, the structural-related class of non-haem globins in Bacillus subtilis, Moorella thermoacetica, and Bacillus anthracis, and a haemerythrin-coupled diguanylate cyclase in Vibrio cholerae. This review summarizes the structures, the functions, and the structure-function relationships known to date on this broad protein family. We also propose unresolved questions and new possible research approaches.

  17. A Sensitive Sensor Cell Line for the Detection of Oxidative Stress Responses in Cultured Human Keratinocytes

    Directory of Open Access Journals (Sweden)

    Ute Hofmann

    2014-06-01

    Full Text Available In the progress of allergic and irritant contact dermatitis, chemicals that cause the generation of reactive oxygen species trigger a heat shock response in keratinocytes. In this study, an optical sensor cell line based on cultured human keratinocytes (HaCaT cells expressing green fluorescent protein (GFP under the control of the stress-inducible HSP70B’ promoter were constructed. Exposure of HaCaT sensor cells to 25 µM cadmium, a model substance for oxidative stress induction, provoked a 1.7-fold increase in total glutathione and a ~300-fold induction of transcript level of the gene coding for heat shock protein HSP70B’. An extract of Arnica montana flowers resulted in a strong induction of the HSP70B’ gene and a pronounced decrease of total glutathione in keratinocytes. The HSP70B’ promoter-based sensor cells conveniently detected cadmium-induced stress using GFP fluorescence as read-out with a limit of detection of 6 µM cadmium. In addition the sensor cells responded to exposure of cells to A. montana extract with induction of GFP fluorescence. Thus, the HaCaT sensor cells provide a means for the automated detection of the compromised redox status of keratinocytes as an early indicator of the development of human skin disorders and could be applied for the prediction of skin irritation in more complex in vitro 3D human skin models and in the development of micro-total analysis systems (µTAS that may be utilized in dermatology, toxicology, pharmacology and drug screenings.

  18. A sensitive sensor cell line for the detection of oxidative stress responses in cultured human keratinocytes.

    Science.gov (United States)

    Hofmann, Ute; Priem, Melanie; Bartzsch, Christine; Winckler, Thomas; Feller, Karl-Heinz

    2014-06-25

    In the progress of allergic and irritant contact dermatitis, chemicals that cause the generation of reactive oxygen species trigger a heat shock response in keratinocytes. In this study, an optical sensor cell line based on cultured human keratinocytes (HaCaT cells) expressing green fluorescent protein (GFP) under the control of the stress-inducible HSP70B' promoter were constructed. Exposure of HaCaT sensor cells to 25 µM cadmium, a model substance for oxidative stress induction, provoked a 1.7-fold increase in total glutathione and a ~300-fold induction of transcript level of the gene coding for heat shock protein HSP70B'. An extract of Arnica montana flowers resulted in a strong induction of the HSP70B' gene and a pronounced decrease of total glutathione in keratinocytes. The HSP70B' promoter-based sensor cells conveniently detected cadmium-induced stress using GFP fluorescence as read-out with a limit of detection of 6 µM cadmium. In addition the sensor cells responded to exposure of cells to A. montana extract with induction of GFP fluorescence. Thus, the HaCaT sensor cells provide a means for the automated detection of the compromised redox status of keratinocytes as an early indicator of the development of human skin disorders and could be applied for the prediction of skin irritation in more complex in vitro 3D human skin models and in the development of micro-total analysis systems (µTAS) that may be utilized in dermatology, toxicology, pharmacology and drug screenings.

  19. Piezoresistive Carbon-based Hybrid Sensor for Body-Mounted Biomedical Applications

    Science.gov (United States)

    Melnykowycz, M.; Tschudin, M.; Clemens, F.

    2017-02-01

    For body-mounted sensor applications, the evolution of soft condensed matter sensor (SCMS) materials offer conformability andit enables mechanical compliance between the body surface and the sensing mechanism. A piezoresistive hybrid sensor and compliant meta-material sub-structure provided a way to engineer sensor physical designs through modification of the mechanical properties of the compliant design. A piezoresistive fiber sensor was produced by combining a thermoplastic elastomer (TPE) matrix with Carbon Black (CB) particles in 1:1 mass ratio. Feedstock was extruded in monofilament fiber form (diameter of 300 microns), resulting in a highly stretchable sensor (strain sensor range up to 100%) with linear resistance signal response. The soft condensed matter sensor was integrated into a hybrid design including a 3D printed metamaterial structure combined with a soft silicone. An auxetic unit cell was chosen (with negative Poisson’s Ratio) in the design in order to combine with the soft silicon, which exhibits a high Poisson’s Ratio. The hybrid sensor design was subjected to mechanical tensile testing up to 50% strain (with gauge factor calculation for sensor performance), and then utilized for strain-based sensing applications on the body including gesture recognition and vital function monitoring including blood pulse-wave and breath monitoring. A 10 gesture Natural User Interface (NUI) test protocol was utilized to show the effectiveness of a single wrist-mounted sensor to identify discrete gestures including finger and hand motions. These hand motions were chosen specifically for Human Computer Interaction (HCI) applications. The blood pulse-wave signal was monitored with the hand at rest, in a wrist-mounted. In addition different breathing patterns were investigated, including normal breathing and coughing, using a belt and chest-mounted configuration.

  20. Plasmonics Based Harsh Environment Compatible Chemical Sensors

    Energy Technology Data Exchange (ETDEWEB)

    Michael Carpenter

    2012-01-15

    Au-YSZ, Au-TiO{sub 2} and Au-CeO{sub 2} nanocomposite films have been investigated as a potential sensing element for high-temperature plasmonic sensing of H{sub 2}, CO, and NO{sub 2} in an oxygen containing environment. The Au-YSZ and Au-TiO{sub 2} films were deposited using PVD methods, while the CeO{sub 2} thin film was deposited by molecular beam epitaxy (MBE) and Au was implanted into the as-grown film at an elevated temperature followed by high temperature annealing to form well-defined Au nanoclusters. Each of the films were characterized by x-ray diffraction (XRD) and Rutherford backscattering spectrometry (RBS). For the gas sensing experiments, separate exposures to varying concentrations of H{sub 2}, CO, and NO{sub 2} were performed at a temperature of 500°C in oxygen backgrounds of 5.0, 10, and ~21% O{sub 2}. Changes in the localized surface plasmon resonance (LSPR) absorption peak were monitored during gas exposures and are believed to be the result of oxidation-reduction processes that fill or create oxygen vacancies in the respective metal oxides. This process affects the LSPR peak position either by charge exchange with the Au nanoparticles or by changes in the dielectric constant surrounding the particles. Hyperspectral multivariate analysis was used to gauge the inherent selectivity of the film between the separate analytes. From principal component analysis (PCA), unique and identifiable responses were seen for each of the analytes. Linear discriminant analysis (LDA) was also used on the Au-CeO{sub 2} results and showed separation between analytes as well as trends in gas concentration. Results indicate that each of the films are is selective towards O{sub 2}, H{sub 2}, CO, and NO{sub 2} in separate exposures. However, when the films were analyzed in a sensor array based experiment, ie simultaneous exposures to the target gases, PCA analysis of the combined response showed an even greater selective character towards the target gases. Combined

  1. Optical hydrogen sensors based on metal-hydrides

    Science.gov (United States)

    Slaman, M.; Westerwaal, R.; Schreuders, H.; Dam, B.

    2012-06-01

    For many hydrogen related applications it is preferred to use optical hydrogen sensors above electrical systems. Optical sensors reduce the risk of ignition by spark formation and are less sensitive to electrical interference. Currently palladium and palladium alloys are used for most hydrogen sensors since they are well known for their hydrogen dissociation and absorption properties at relatively low temperatures. The disadvantages of palladium in sensors are the low optical response upon hydrogen loading, the cross sensitivity for oxygen and carbon, the limited detection range and the formation of micro-cracks after some hydrogen absorption/desorption cycles. In contrast to Pd, we find that the use of magnesium or rear earth bases metal-hydrides in optical hydrogen sensors allow tuning of the detection levels over a broad pressure range, while maintaining a high optical response. We demonstrate a stable detection layer for detecting hydrogen below 10% of the lower explosion limit in an oxygen rich environment. This detection layer is deposited at the bare end of a glass fiber as a micro-mirror and is covered with a thin layer of palladium. The palladium layer promotes the hydrogen uptake at room temperature and acts as a hydrogen selective membrane. To protect the sensor for a long time in air a final layer of a hydrophobic fluorine based coating is applied. Such a sensor can be used for example as safety detector in automotive applications. We find that this type of fiber optic hydrogen sensor is also suitable for hydrogen detection in liquids. As example we demonstrate a sensor for detecting a broad range of concentrations in transformer oil. Such a sensor can signal a warning when sparks inside a high voltage power transformer decompose the transformer oil over a long period.

  2. Modeling Sensor Reliability in Fault Diagnosis Based on Evidence Theory.

    Science.gov (United States)

    Yuan, Kaijuan; Xiao, Fuyuan; Fei, Liguo; Kang, Bingyi; Deng, Yong

    2016-01-18

    Sensor data fusion plays an important role in fault diagnosis. Dempster-Shafer (D-R) evidence theory is widely used in fault diagnosis, since it is efficient to combine evidence from different sensors. However, under the situation where the evidence highly conflicts, it may obtain a counterintuitive result. To address the issue, a new method is proposed in this paper. Not only the statistic sensor reliability, but also the dynamic sensor reliability are taken into consideration. The evidence distance function and the belief entropy are combined to obtain the dynamic reliability of each sensor report. A weighted averaging method is adopted to modify the conflict evidence by assigning different weights to evidence according to sensor reliability. The proposed method has better performance in conflict management and fault diagnosis due to the fact that the information volume of each sensor report is taken into consideration. An application in fault diagnosis based on sensor fusion is illustrated to show the efficiency of the proposed method. The results show that the proposed method improves the accuracy of fault diagnosis from 81.19% to 89.48% compared to the existing methods.

  3. A novel microbial fuel cell sensor with biocathode sensing element.

    Science.gov (United States)

    Jiang, Yong; Liang, Peng; Liu, Panpan; Wang, Donglin; Miao, Bo; Huang, Xia

    2017-03-02

    The traditional microbial fuel cell (MFC) sensor with bioanode as sensing element delivers limited sensitivity to toxicity monitoring, restricted application to only anaerobic and organic rich water body, and increased potential fault warning to the combined shock of organic matter/toxicity. In this study, the biocathode for oxygen reduction reaction was employed for the first time as the sensing element in MFC sensor for toxicity monitoring. The results shown that the sensitivity of MFC sensor with biocathode sensing element (7.4±2.0 to 67.5±4.0mA%(-1)cm(-2)) was much greater than that showed by bioanode sensing element (3.4±1.5 to 5.5±0.7mA%(-1)cm(-2)). The biocathode sensing element achieved the lowest detection limit reported to date using MFC sensor for formaldehyde detection (0.0005%), while the bioanode was more applicable for higher concentration (>0.0025%). There was a quicker response of biocathode sensing element with the increase of conductivity and dissolved oxygen (DO). The biocathode sensing element made the MFC sensor directly applied to clean water body monitoring, e.g., drinking water and reclaimed water, without the amending of background organic matter, and it also decreased the warning failure when challenged by a combined shock of organic matter/toxicity.

  4. Analysis of Vehicle Detection with WSN-Based Ultrasonic Sensors

    Directory of Open Access Journals (Sweden)

    Youngtae Jo

    2014-08-01

    Full Text Available Existing traffic information acquisition systems suffer from high cost and low scalability. To address these problems, the application of wireless sensor networks (WSNs has been studied, as WSN-based systems are highly scalable and have a low cost of installing and replacing the systems. Magnetic, acoustic and accelerometer sensors have been considered for WSN-based traffic surveillance, but the use of ultrasonic sensors has not been studied. The limitations of WSN-based systems make it necessary to employ power saving methods and vehicle detection algorithms with low computational complexity. In this paper, we model and analyze optimal power saving methodologies for an ultrasonic sensor and present a computationally-efficient vehicle detection algorithm using ultrasonic data. The proposed methodologies are implemented and evaluated with a tiny microprocessor on real roads. The evaluation results show that the low computational complexity of our algorithm does not compromise the accuracy of vehicle detection.

  5. A torsional sensor for MEMS-based RMS voltage measurements

    Directory of Open Access Journals (Sweden)

    J. Dittmer

    2008-05-01

    Full Text Available RF voltage measurement based on electrostatic RMS voltage-to-force conversion is an alternative method in comparison to the conventional thermal power dissipation method. It is based on a mechanical force induced by an RF voltage applied to a micro-mechanical system. For a theoretically adequate resolution and high precision measurements, the necessary geometrical dimensions of the sensor require the application of micro machining. In this contribution, the dependence between electrical and geometrical properties of different sensor designs is investigated. Based on these results, problems related to practical micro-machining and solutions with respect to possible sensor realizations are discussed. The evolution of different sensor generations is shown.

  6. Analysis of vehicle detection with WSN-based ultrasonic sensors.

    Science.gov (United States)

    Jo, Youngtae; Jung, Inbum

    2014-08-04

    Existing traffic information acquisition systems suffer from high cost and low scalability. To address these problems, the application of wireless sensor networks (WSNs) has been studied, as WSN-based systems are highly scalable and have a low cost of installing and replacing the systems. Magnetic, acoustic and accelerometer sensors have been considered for WSN-based traffic surveillance, but the use of ultrasonic sensors has not been studied. The limitations of WSN-based systems make it necessary to employ power saving methods and vehicle detection algorithms with low computational complexity. In this paper, we model and analyze optimal power saving methodologies for an ultrasonic sensor and present a computationally-efficient vehicle detection algorithm using ultrasonic data. The proposed methodologies are implemented and evaluated with a tiny microprocessor on real roads. The evaluation results show that the low computational complexity of our algorithm does not compromise the accuracy of vehicle detection.

  7. Higher-order mode photonic crystal based nanofluidic sensor

    Science.gov (United States)

    Peng, Wang; Chen, Youping; Ai, Wu

    2017-01-01

    A higher-order photonic crystal (PC) based nanofluidic sensor, which worked at 532 nm, was designed and demonstrated. A systematical and detailed method for sculpturing a PC sensor for a given peak wavelength value (PWV) and specified materials was illuminated. It was the first time that the higher order mode was used to design PC based nanofluidic sensor, and the refractive index (RI) sensitivity of this sensor had been verified with FDTD simulation software from Lumerical. The enhanced electrical field of higher order mode structure was mostly confined in the channel area, where the enhance field is wholly interacting with the analytes in the channels. The comparison of RI sensitivity between fundamental mode and higher order mode shows the RI variation of higher order mode is 124.5 nm/RIU which is much larger than the fundamental mode. The proposed PC based nanofluidic structure pioneering a novel style for future optofluidic design.

  8. Sensor Technology Baseline Study for Enabling Condition Based Maintenance Plus in Army Ground Vehicles

    Science.gov (United States)

    2012-03-01

    and mechanisms are identified. Based on this analysis, baselines sensor technologies are determined to prognosticate these types failure causes early...Current/voltage sensor measured at sensor terminals; Fluid level sensor Excessive slippage and clutch chatter Internal transmission failure ... TYPE Final 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Sensor Technology Baseline Study for Enabling Condition Based Maintenance Plus in

  9. Force-compensated hydrogel-based pH sensor

    Science.gov (United States)

    Deng, Kangfa; Gerlach, Gerald; Guenther, Margarita

    2015-04-01

    This paper presents the design, simulation, assembly and testing of a force-compensated hydrogel-based pH sensor. In the conventional deflection method, a piezoresistive pressure sensor is used as a chemical-mechanical-electronic transducer to measure the volume change of a pH-sensitive hydrogel. In this compensation method, the pH-sensitive hydrogel keeps its volume constant during the whole measuring process, independent of applied pH value. In order to maintain a balanced state, an additional thermal actuator is integrated into the close-loop sensor system with higher precision and faster dynamic response. Poly (N-isopropylacrylamide) (PNIPAAm) with 5 mol% monomer 3-acrylamido propionic acid (AAmPA) is used as the temperature-sensitive hydrogel, while poly (vinyl alcohol) with poly (acrylic acid) (PAA) serves as the pH-sensitive hydrogel. A thermal simulation is introduced to assess the temperature distribution of the whole microsystem, especially the temperature influence on both hydrogels. Following tests are detailed to verify the working functions of a sensor based on pH-sensitive hydrogel and an actuator based on temperature-sensitive hydrogel. A miniaturized prototype is assembled and investigated in deionized water: the response time amounts to about 25 min, just half of that one of a sensor based on the conventional deflection method. The results confirm the applicability of t he compensation method to the hydrogel-based sensors.

  10. Batteryless, wireless sensor powered by a sediment microbial fuel cell.

    Science.gov (United States)

    Donovan, Conrad; Dewan, Alim; Heo, Deukhyoun; Beyenal, Haluk

    2008-11-15

    Sediment microbial fuel cells (SMFCs) are considered to be an alternative renewable power source for remote monitoring. There are two main challenges to using SMFCs as power sources: 1) a SMFC produces a low potential at which most sensor electronics do not operate, and 2) a SMFC cannot provide continuous power, so energy from the SMFC must be stored and then used to repower sensor electronics intermittently. In this study, we developed a SMFC and a power management system (PMS) to power a batteryless, wireless sensor. A SMFC operating with a microbial anode and cathode, located in the Palouse River, Pullman, Washington, U.S.A., was used to demonstrate the utility of the developed system. The designed PMS stored microbial energy and then started powering the wireless sensor when the SMFC potential reached 320 mV. It continued powering until the SMFC potential dropped below 52 mV. The system was repowered when the SMFC potential increased to 320 mV, and this repowering continued as long as microbial reactions continued. We demonstrated that a microbial fuel cell with a microbial anode and cathode can be used as an effective renewable power source for remote monitoring using custom-designed electronics.

  11. Nanomaterial Based Sensors for NASA Missions

    Science.gov (United States)

    Koehne, Jessica E.

    2016-01-01

    Nanomaterials such as carbon nanotubes (CNTs), carbon nanofibers (CNFs), graphene and metal nanowires have shown interesting electronic properties and therefore have been pursued for a variety of space applications requiring ultrasensitive and light-weight sensor and electronic devices. We have been pursuing development of chemical and biosensors using carbon nanotubes and carbon nanofibers for the last several years and this talk will present the benefits of nanomaterials these applications. More recently, printing approaches to manufacturing these devices have been explored as a strategy that is compatible to a microgravity environment. Nanomaterials are either grown in house or purchased and processed as electrical inks. Chemical modification or coatings are added to the nanomaterials to tailor the nanomaterial to the exact application. The development of printed chemical sensors and biosensors will be discussed for applications ranging from crew life support to exploration missions.

  12. Enzyme-Based Fiber Optic Sensors

    Science.gov (United States)

    Kulp, Thomas J.; Camins, Irene; Angel, Stanley M.

    1988-06-01

    Fiber optic chemical sensors capable of detecting glucose and penicillin were developed. Each consists of a polymer membrane that is covalently attached to the tip of a glass optical fiber. The membrane contains the enzyme and a pH-sensitive fluorescent dye (fluorescein). A signal is produced when the enzyme catalyzes the conversion of the analyte (glucose or penicillin) into a product (gluconic or penicilloic acid, respectively) that lowers the microenvironmental pH of the membrane and, consequently, lowers the fluorescence intensity of the dye. Each sensor is capable of responding to analyte concentrations in the range of ~0.1 to 100 mM. The penicillin optrode response time is 40 to 60 s while that for glucose is ~5 to 12 min.

  13. Sensor-fusion-based biometric identity verification

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, J.J.; Bouchard, A.M.; Osbourn, G.C.; Martinez, R.F.; Bartholomew, J.W. [Sandia National Labs., Albuquerque, NM (United States); Jordan, J.B.; Flachs, G.M.; Bao, Z.; Zhu, L. [New Mexico State Univ., Las Cruces, NM (United States). Electronic Vision Research Lab.

    1998-02-01

    Future generation automated human biometric identification and verification will require multiple features/sensors together with internal and external information sources to achieve high performance, accuracy, and reliability in uncontrolled environments. The primary objective of the proposed research is to develop a theoretical and practical basis for identifying and verifying people using standoff biometric features that can be obtained with minimal inconvenience during the verification process. The basic problem involves selecting sensors and discovering features that provide sufficient information to reliably verify a person`s identity under the uncertainties caused by measurement errors and tactics of uncooperative subjects. A system was developed for discovering hand, face, ear, and voice features and fusing them to verify the identity of people. The system obtains its robustness and reliability by fusing many coarse and easily measured features into a near minimal probability of error decision algorithm.

  14. Electro-active material (EAM) based bend sensors

    Science.gov (United States)

    LaComb, Ronald; LaComb, Julie

    2010-04-01

    The capability to accurately estimate strain and orientation of cables in an undersea environment is important for a multitude of applications. One way to estimate the positional location of a submersed cable is to utilize a network of distributed bend sensors providing inputs to a curve fitting algorithm. In this work commercially available bend sensors are characterized for small deflections. In addition proto-type devices are presented which can potentially improve device sensitivity. Commercially available bend sensors are based upon electro-active materials and variable resistance materials. Electro-active materials (EAM) are known for their actuator functionality but certain EAMs are capable of sensing as well. New advances in materials such as Ionic Polymer Metal Composites (IPMC) are proving suitable for quasi-static sensor applications. These sensors are low power, conformal and produce directionally dependent output voltages which are linearly proportional to deflection, with voltage polarity representative of the deflection direction. IPMCs are capable of being morphed for increased sensitivity. Variable resistivity sensors are based on smart epoxy polymer and carbon loaded inks. These sensors are inexpensive and conformal and unlike EAMs provide static measurements.

  15. LTCC based bioreactors for cell cultivation

    Science.gov (United States)

    Bartsch, H.; Welker, T.; Welker, K.; Witte, H.; Müller, J.

    2016-01-01

    LTCC multilayers offer a wide range of structural options and flexibility of connections not available in standard thin film technology. Therefore they are considered as material base for cell culture reactors. The integration of microfluidic handling systems and features for optical and electrical capturing of indicators for cell culture growth offers the platform for an open system concept. The present paper assesses different approaches for the creation of microfluidic channels in LTCC multilayers. Basic functions required for the fluid management in bioreactors include temperature and flow control. Both features can be realized with integrated heaters and temperature sensors in LTCC multilayers. Technological conditions for the integration of such elements into bioreactors are analysed. The temperature regulation for the system makes use of NTC thermistor sensors which serve as real value input for the control of the heater. It allows the adjustment of the fluid temperature with an accuracy of 0.2 K. The tempered fluid flows through the cell culture chamber. Inside of this chamber a thick film electrode array monitors the impedance as an indicator for the growth process of 3-dimensional cell cultures. At the system output a flow sensor is arranged to monitor the continual flow. For this purpose a calorimetric sensor is implemented, and its crucial design parameters are discussed. Thus, the work presented gives an overview on the current status of LTCC based fluid management for cell culture reactors, which provides a promising base for the automation of cell culture processes.

  16. On-Orbit, Immuno-Based, Label-Free White Blood Cell Counting System with Microelectromechanical Sensor Technology (OILWBCS-MEMS)

    Science.gov (United States)

    Edmonds, Jessica

    2015-01-01

    Aurora Flight Sciences, in partnership with Draper Laboratory, has developed a miniaturized system to count white blood cells in microgravity environments. The system uses MEMS technology to simultaneously count total white blood cells, the five white blood cell differential subgroups, and various lymphocyte subtypes. The OILWBCS-MEMS detection technology works by immobilizing an array of white blood cell-specific antibodies on small, gold-coated membranes. When blood flows across the membranes, specific cells' surface protein antigens bind to their corresponding antibodies. This binding can be measured and correlated to cell counts. In Phase I, the partners demonstrated surface chemistry sensitivity and specificity for total white blood cells and two lymphocyte subtypes. In Phase II, a functional prototype demonstrated end-to-end operation. This rugged, miniaturized device requires minimal blood sample preparation and will be useful for both space flight and terrestrial applications.

  17. Chemical sensors based on molecularly modified metallic nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Haick, Hossam [Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa 32000 (Israel)

    2007-12-07

    This paper presents a concise, although admittedly non-exhaustive, didactic review of some of the main concepts and approaches related to the use of molecularly modified metal nanoparticles in or as chemical sensors. This paper attempts to pull together different views and terminologies used in sensors based on molecularly modified metal nanoparticles, including those established upon electrochemical, optical, surface Plasmon resonance, piezoelectric and electrical transduction approaches. Finally, this paper discusses briefly the main advantages and disadvantages of each of the presented class of sensors. (review article)

  18. System modeling based measurement error analysis of digital sun sensors

    Institute of Scientific and Technical Information of China (English)

    WEI; M; insong; XING; Fei; WANG; Geng; YOU; Zheng

    2015-01-01

    Stringent attitude determination accuracy is required for the development of the advanced space technologies and thus the accuracy improvement of digital sun sensors is necessary.In this paper,we presented a proposal for measurement error analysis of a digital sun sensor.A system modeling including three different error sources was built and employed for system error analysis.Numerical simulations were also conducted to study the measurement error introduced by different sources of error.Based on our model and study,the system errors from different error sources are coupled and the system calibration should be elaborately designed to realize a digital sun sensor with extra-high accuracy.

  19. Nanostructured Polypyrrole-Based Ammonia and Volatile Organic Compound Sensors

    Directory of Open Access Journals (Sweden)

    Milena Šetka

    2017-03-01

    Full Text Available The aim of this review is to summarize the recent progress in the fabrication of efficient nanostructured polymer-based sensors with special focus on polypyrrole. The correlation between physico-chemical parameters, mainly morphology of various polypyrrole nanostructures, and their sensitivity towards selected gas and volatile organic compounds (VOC is provided. The different approaches of polypyrrole modification with other functional materials are also discussed. With respect to possible sensors application in medicine, namely in the diagnosis of diseases via the detection of volatile biomarkers from human breath, the sensor interaction with humidity is described as well. The major attention is paid to analytes such as ammonia and various alcohols.

  20. Transparent and flexible force sensor array based on optical waveguide.

    Science.gov (United States)

    Kim, Youngsung; Park, Suntak; Park, Seung Koo; Yun, Sungryul; Kyung, Ki-Uk; Sun, Kyung

    2012-06-18

    This paper suggests a force sensor array measuring contact force based on intensity change of light transmitted throughout optical waveguide. For transparency and flexibility of the sensor, two soft prepolymers with different refractive index have been developed. The optical waveguide consists of two cladding layers and a core layer. The top cladding layer is designed to allow light scattering at the specific area in response to finger contact. The force sensor shows a distinct tendency that output intensity decreases with input force and measurement range is from 0 to -13.2 dB.

  1. A Passive Optical Fiber Current Sensor Based on YIG

    Institute of Scientific and Technical Information of China (English)

    Jing Shao; Wen Liu; Cui-Qing Liu; Duan Xu

    2008-01-01

    A research on passive optical fiber current sensor based on magneto-optical crystal and a new design of light path of the sensor head are presented. Both methods of dual-channel optical detection of the polarization state of the output light and signal processing are proposed. Signal processing can obtain the linear output of the current measurement of the wire more conveniently. Theoretical analysis on the magneto-optical fiber current sensor is given, followed by experiments. After that, further analysis is made according to the results, which leads to clarifying the exiting problems and their placements.

  2. A Solution-Based Temperature Sensor Using the Organic Compound CuTsPc

    Directory of Open Access Journals (Sweden)

    Shahino Mah Abdullah

    2014-06-01

    Full Text Available An electrochemical cell using an organic compound, copper (II phthalocyanine-tetrasulfonic acid tetrasodium salt (CuTsPc, has been fabricated and investigated as a solution-based temperature sensor. The capacitance and resistance of the ITO/CuTsPc solution/ITO chemical cell has been characterized as a function of temperature in the temperature range of 25–80 °C. A linear response with minimal hysteresis is observed. The fabricated temperature sensor has shown high consistency and sensitive response towards a specific range of temperature values.

  3. C60-based clustering scheme for sensor management in STSS

    Institute of Scientific and Technical Information of China (English)

    Yiyu Zhou

    2015-01-01

    Clustering-based sensor-management schemes have been widely used for various wireless sensor networks (WSNs), as they are wel suited to the distributive and col aborative nature of WSN. In this paper, a C60-based clustering algorithm is proposed for the specific planned network of space tracking and surveil ance system (STSS), where al the sensors are partitioned into 12 clus-ters according to the C60 (or footbal surface) architecture, and then a hierarchical sensor-management scheme is wel designed. Final y, the algorithm is applied to a typical STSS constel ation, and the simulation results show that the proposed method has bet-ter target-tracking performance than the nonclustering scheduling method.

  4. Voronoi-based localisation algorithm for mobile sensor networks

    Science.gov (United States)

    Guan, Zixiao; Zhang, Yongtao; Zhang, Baihai; Dong, Lijing

    2016-11-01

    Localisation is an essential and important part in wireless sensor networks (WSNs). Many applications require location information. So far, there are less researchers studying on mobile sensor networks (MSNs) than static sensor networks (SSNs). However, MSNs are required in more and more areas such that the number of anchor nodes can be reduced and the location accuracy can be improved. In this paper, we firstly propose a range-free Voronoi-based Monte Carlo localisation algorithm (VMCL) for MSNs. We improve the localisation accuracy by making better use of the information that a sensor node gathers. Then, we propose an optimal region selection strategy of Voronoi diagram based on VMCL, called ORSS-VMCL, to increase the efficiency and accuracy for VMCL by adapting the size of Voronoi area during the filtering process. Simulation results show that the accuracy of these two algorithms, especially ORSS-VMCL, outperforms traditional MCL.

  5. RESTFul based heterogeneous Geoprocessing workflow interoperation for Sensor Web Service

    Science.gov (United States)

    Yang, Chao; Chen, Nengcheng; Di, Liping

    2012-10-01

    Advanced sensors on board satellites offer detailed Earth observations. A workflow is one approach for designing, implementing and constructing a flexible and live link between these sensors' resources and users. It can coordinate, organize and aggregate the distributed sensor Web services to meet the requirement of a complex Earth observation scenario. A RESTFul based workflow interoperation method is proposed to integrate heterogeneous workflows into an interoperable unit. The Atom protocols are applied to describe and manage workflow resources. The XML Process Definition Language (XPDL) and Business Process Execution Language (BPEL) workflow standards are applied to structure a workflow that accesses sensor information and one that processes it separately. Then, a scenario for nitrogen dioxide (NO2) from a volcanic eruption is used to investigate the feasibility of the proposed method. The RESTFul based workflows interoperation system can describe, publish, discover, access and coordinate heterogeneous Geoprocessing workflows.

  6. Optimize Etching Based Single Mode Fiber Optic Temperature Sensor

    Directory of Open Access Journals (Sweden)

    Ajay Kumar

    2014-02-01

    Full Text Available This paper presents a description of etching process for fabrication single mode optical fiber sensors. The process of fabrication demonstrates an optimized etching based method to fabricate single mode fiber (SMF optic sensors in specified constant time and temperature. We propose a single mode optical fiber based temperature sensor, where the temperature sensing region is obtained by etching its cladding diameter over small length to a critical value. It is observed that the light transmission through etched fiber at 1550 nm wavelength optical source becomes highly temperature sensitive, compared to the temperature insensitive behavior observed in un-etched fiber for the range on 30ºC to 100ºC at 1550 nm. The sensor response under temperature cycling is repeatable and, proposed to be useful for low frequency analogue signal transmission over optical fiber by means of inline thermal modulation approach.

  7. Triangle-based key management scheme for wireless sensor networks

    Institute of Scientific and Technical Information of China (English)

    Hangyang DAI; Hongbing XU

    2009-01-01

    For security services in wireless sensor net-works, key management is a fundamental building block.In this article, we propose a triangle-based key predis-tribution approach and show that it can improve the effectiveness of key management in wireless sensor networks. This is achieved by using the bivariate polynomial in a triangle deployment system based on deployment information about expected locations of the sensor nodes. The analysis indicates that this scheme can achieve higher probability of both direct key establishment and indirect key establishment. On the other hand, the security analysis shows that its security against node capture would increase with a decrease of the sensor node deployment density and size of the deployment model and an increase of the polynomial degree.

  8. Noninvasive Temperature Measurement Based on Microwave Temperature Sensor

    OpenAIRE

    Shoucheng Ding

    2013-01-01

    In this study, we have a research of the noninvasive temperature measurement based on microwave temperature sensor. Moreover, in order to solve the surface temperature measurement for designing microwave temperature sensor, the microwave was issued by the transmitting antenna. Microwave encountered by the measured object to return back to the measured object and then convert it into electrical signals, the use of the quantitative relationship between this signal and input noise temperature to...

  9. Fiber Optic Temperature Sensor Based on Multimode Interference Effects

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Soto, J G; Antonio-Lopez, J E; Sanchez-Mondragon, J J [Photonics and Optical Physics Laboratory, Optics Department, INAOE Apdo. Postal 51 and 216, Tonantzintla, Puebla 72000 (Mexico); May-Arrioja, D A, E-mail: darrioja@uat.edu.mx

    2011-01-01

    A novel fiber optic temperature sensor based on multimode interference was designed, fabricated and tested. The sensor is very simple and inexpensive since we only need to splice a section of multimode fiber between two single mode fibers. Using this device a sensing range of 25 deg. C to 375 deg. C is demonstrated. We should also highlight that due to the pass-band filter response of MMI devices, multiplexing is rather simple by just changing the length of the multimode section.

  10. Fiber Bragg Grating Pressure Sensor Based on Corrugated Diaphragm

    Institute of Scientific and Technical Information of China (English)

    FU Hai-wei; FU Jun-mei; QIAO Xue-guang

    2004-01-01

    A kind of fiber Bragg grating pressure sensor based on corrugated diaphragm is proposed. The relationship between the central wavelength of reflective wave of FBG and pressure is given, and the expression of the pressure sensitivity coefficient is also given. Within the range from results agree with the theoretical analysis. It is indicated that the expected pressure sensitivity of the sensor can be obtained by optimizing the size and mechanical parameters of the corrugated diaphragm.

  11. A Hierarchical Sensor Network Based on Voronoi Diagram

    Institute of Scientific and Technical Information of China (English)

    SHANG Rui-qiang; ZHAO Jian-li; SUN Qiu-xia; WANG Guang-xing

    2006-01-01

    A hierarchical sensor network is proposed which places the sensing and routing capacity at different layer nodes.It thus simplifies the hardware design and reduces cost. Adopting Voronoi diagram in the partition of backbone network,a mathematical model of data aggregation based on hierarchical architecture is given. Simulation shows that the number of transmission data packages is sharply cut down in the network, thus reducing the needs in the bandwidth and energy resources and is thus well adapted to sensor networks.

  12. Molecularly Imprinted Polymer/Metal Organic Framework Based Chemical Sensors

    Directory of Open Access Journals (Sweden)

    Zhenzhong Guo

    2016-10-01

    Full Text Available The present review describes recent advances in the concept of molecular imprinting using metal organic frameworks (MOF for development of chemical sensors. Two main strategies regarding the fabrication, performance and applications of recent sensors based on molecularly imprinted polymers associated with MOF are presented: molecularly imprinted MOF films and molecularly imprinted core-shell nanoparticles using MOF as core. The associated transduction modes are also discussed. A brief conclusion and future expectations are described herein.

  13. Molecularly Imprinted Polymer/Metal Organic Framework Based Chemical Sensors

    OpenAIRE

    Zhenzhong Guo; Anca Florea; Mengjuan Jiang; Yong Mei; Weiying Zhang; Aidong Zhang; Robert Săndulescu; Nicole Jaffrezic-Renault

    2016-01-01

    The present review describes recent advances in the concept of molecular imprinting using metal organic frameworks (MOF) for development of chemical sensors. Two main strategies regarding the fabrication, performance and applications of recent sensors based on molecularly imprinted polymers associated with MOF are presented: molecularly imprinted MOF films and molecularly imprinted core-shell nanoparticles using MOF as core. The associated transduction modes are also discussed. A brief conclu...

  14. Microbial fuel cells as power supply of a low-power temperature sensor

    Science.gov (United States)

    Khaled, Firas; Ondel, Olivier; Allard, Bruno

    2016-02-01

    Microbial fuel cells (MFCs) show great promise as a concomitant process for water treatment and as renewable energy sources for environmental sensors. The small energy produced by MFCs and the low output voltage limit the applications of MFCs. Specific converter topologies are required to step-up the output voltage of a MFC. A Power Management Unit (PMU) is proposed for operation at low input voltage and at very low power in a completely autonomous way to capture energy from MFCs with the highest possible efficiency. The application of sensors for monitoring systems in remote locations is an important approach. MFCs could be an alternative energy source in this case. Powering a sensor with MFCs may prove the fact that wastewater may be partly turned into renewable energy for realistic applications. The Power Management Unit is demonstrated for 3.6 V output voltage at 1 mW continuous power, based on a low-cost 0.7-L MFC. A temperature sensor may operate continuously on 2-MFCs in continuous flow mode. A flyback converter under discontinuous conduction mode is also tested to power the sensor. One continuously fed MFC was able to efficiently and continuously power the sensor.

  15. A Calibration Report for Wireless Sensor-Based Weatherboards

    Directory of Open Access Journals (Sweden)

    Muthoni Masinde

    2015-03-01

    Full Text Available Sub-Saharan Africa contains the highest number of people affected by droughts. Although this can easily be mitigated through the provision of timely, reliable and relevant weather forecasts, the sparse network of weather stations in most of these countries makes this difficult. Rapid development in wireless sensor networks has resulted in weatherboards capable of capturing weather parameters at the micro-level. Although these weatherboards offer a viable solution to Africa’s drought, the acceptability of such data by meteorologists is only possible if these sensors are calibrated and their field readiness scientifically evaluated. This is the contribution of this paper; we present results of a calibration exercise that was carried out to: (1 measure and correct lag, random and systematic errors; (2 determine if Perspex was an ideal material for building sensor boards’ enclosures; and (3 identify sensor boards’ battery charging and depletion rates. The result is a calibration report detailing actual error and uncertainty values for atmospheric pressure, humidity and temperature sensors, as well as the recharge and discharge curves of the batteries. The results further ruled out the use of Perspex for enclosing the sensor boards. These experiments pave the way for the design and implementation of a sensor-based weather monitoring system (SenseWeather that was piloted in two regions in Kenya.

  16. Magnetic Sensors Based on Amorphous Ferromagnetic Materials: A Review.

    Science.gov (United States)

    Morón, Carlos; Cabrera, Carolina; Morón, Alberto; García, Alfonso; González, Mercedes

    2015-11-11

    Currently there are many types of sensors that are used in lots of applications. Among these, magnetic sensors are a good alternative for the detection and measurement of different phenomena because they are a "simple" and readily available technology. For the construction of such devices there are many magnetic materials available, although amorphous ferromagnetic materials are the most suitable. The existence in the market of these materials allows the production of different kinds of sensors, without requiring expensive manufacture investments for the magnetic cores. Furthermore, these are not fragile materials that require special care, favouring the construction of solid and reliable devices. Another important feature is that these sensors can be developed without electric contact between the measuring device and the sensor, making them especially fit for use in harsh environments. In this review we will look at the main types of developed magnetic sensors. This work presents the state of the art of magnetic sensors based on amorphous ferromagnetic materials used in modern technology: security devices, weapon detection, magnetic maps, car industry, credit cards, etc.

  17. Magnetic Sensors Based on Amorphous Ferromagnetic Materials: A Review

    Directory of Open Access Journals (Sweden)

    Carlos Morón

    2015-11-01

    Full Text Available Currently there are many types of sensors that are used in lots of applications. Among these, magnetic sensors are a good alternative for the detection and measurement of different phenomena because they are a “simple” and readily available technology. For the construction of such devices there are many magnetic materials available, although amorphous ferromagnetic materials are the most suitable. The existence in the market of these materials allows the production of different kinds of sensors, without requiring expensive manufacture investments for the magnetic cores. Furthermore, these are not fragile materials that require special care, favouring the construction of solid and reliable devices. Another important feature is that these sensors can be developed without electric contact between the measuring device and the sensor, making them especially fit for use in harsh environments. In this review we will look at the main types of developed magnetic sensors. This work presents the state of the art of magnetic sensors based on amorphous ferromagnetic materials used in modern technology: security devices, weapon detection, magnetic maps, car industry, credit cards, etc.

  18. Silicon nanohybrid-based surface-enhanced Raman scattering sensors.

    Science.gov (United States)

    Wang, Houyu; Jiang, Xiangxu; Lee, Shuit-Tong; He, Yao

    2014-11-01

    Nanomaterial-based surface-enhanced Raman scattering (SERS) sensors are highly promising analytical tools, capable of ultrasensitive, multiplex, and nondestructive detection of chemical and biological species. Extensive efforts have been made to design various silicon nanohybrid-based SERS substrates such as gold/silver nanoparticle (NP)-decorated silicon nanowires, Au/Ag NP-decorated silicon wafers (AuNP@Si), and so forth. In comparison to free AuNP- and AgNP-based SERS sensors, the silicon nanohybrid-based SERS sensors feature higher enhancement factors (EFs) and excellent reproducibility, since SERS hot spots are efficiently coupled and stabilized through interconnection to the semiconducting silicon substrates. Consequently, in the past decade, giant advancements in the development of silicon nanohybrid-based SERS sensors have been witnessed for myriad sensing applications. In this review, the representative achievements related to the design of high-performance silicon nanohybrid-based SERS sensors and their use for chemical and biological analysis are reviewed in a detailed way. Furthermore, the major opportunities and challenges in this field are discussed from a broad perspective and possible future directions.

  19. An Optical Pressure Sensor Based on MEMS

    Institute of Scientific and Technical Information of China (English)

    Tong Zhang; Sheng Qiang; Frank Lewis; Yalin Wu; Xiaozhu Chi

    2006-01-01

    An optical fiber pressure sensor has been developed for the measurement in human body. The sensing element is possessed of a membrane structure, which is fabricated by micromachining. The fabrication process includes anisotropic wet etching on the silicon wafer. For the transmitting source and signal light, a multimode optical fiber 50/125 μm (core/clad) in diameter was used. The intensity of the light reflected back into the fiber varies with the membrane deflection, which is a function of pressure. The deflection of the membrane by applied pressure can be mathematically described.

  20. Electrochemical sensors and biosensors based on less aggregated graphene.

    Science.gov (United States)

    Bo, Xiangjie; Zhou, Ming; Guo, Liping

    2017-03-15

    As a novel single-atom-thick sheet of sp(2) hybridized carbon atoms, graphene (GR) has attracted extensive attention in recent years because of its unique and remarkable properties, such as excellent electrical conductivity, large theoretical specific surface area, and strong mechanical strength. However, due to the π-π interaction, GR sheets are inclined to stack together, which may seriously degrade the performance of GR with the unique single-atom layer. In recent years, an increasing number of GR-based electrochemical sensors and biosensors are reported, which may reflect that GR has been considered as a kind of hot and promising electrode material for electrochemical sensor and biosensor construction. However, the active sites on GR surface induced by the irreversible GR aggregations would be deeply secluded inside the stacked GR sheets and therefore are not available for the electrocatalysis. So the alleviation or the minimization of the aggregation level for GR sheets would facilitate the exposure of active sites on GR and effectively upgrade the performance of GR-based electrochemical sensors and biosensors. Less aggregated GR with low aggregation and high dispersed structure can be used in improving the electrochemical activity of GR-based electrochemical sensors or biosensors. In this review, we summarize recent advances and new progress for the development of electrochemical sensors based on less aggregated GR. To achieve such goal, many strategies (such as the intercalation of carbon materials, surface modification, and structural engineering) have been applied to alleviate the aggregation level of GR in order to enhance the performance of GR-based electrochemical sensors and biosensors. Finally, the challenges associated with less aggregated GR-based electrochemical sensors and biosensors as well as related future research directions are discussed.

  1. NANODIAMONDS FOR FLUORESCENT CELL AND SENSOR NANOTECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    V. I. Nazarenko

    2013-10-01

    Full Text Available This review addresses the analysis of properties and applications of fluorescent nanodiamonds. They are carbon nanostructures with atomic arrangement of a diamond and carry all its properties, including record — high density, rigidity and refraction index. They are of almost spherical shape, and their small size (~4–10 nm creates substantial surface area that can be used for absorption of different compounds including drugs. Their surface is formed by different chemical groups (hydroxyls, carboxyls, etc. exhibits also chemical reactivity that allows different types of modifications. This opens innumerable possibilities for constructing different functional nanomaterials. The technologies have been developed for making these nanodiamonds fluorescent. Particularly, these properties are achieved by radioactive treatment with the formation of N–V impurities. These particles absorb and emit light in convenient for observation visible range of spectrum. They do not photobleach, which is very attractive for fluorescent microscopy of the cell. And, finally, these nanoparticles do not display toxicity on the cellular or whole — body level, and because of their biocompatibility they can be used in vivo as contrast agents and drug carriers. It is expected that future biotechnological applications of these nanoparticles will be connected with the creation of nanocomposites that combine multiple useful functions.

  2. Gas Sensors Based on Ceramic p-n Heterocontacts

    Energy Technology Data Exchange (ETDEWEB)

    Seymen Murat Aygun

    2004-12-19

    Ceramic p-n heterocontacts based on CuO/ZnO were successfully synthesized and a systematic study of their hydrogen sensitivity was conducted. The sensitivity and response rates of CuO/ZnO sensors were studied utilizing current-voltage, current-time, and impedance spectroscopy measurements. The heterocontacts showed well-defined rectifying characteristics and were observed to detect hydrogen via both dc and ac measurements. Surface coverage data were derived from current-time measurements which were then fit to a two-site Langmuir adsorption model quite satisfactorily. The fit suggested that there should be two energetically different adsorption sites in the system. The heterocontacts were doped in an attempt to increase the sensitivity and the response rate of the sensor. First, the effects of doping the p-type (CuO) on the sensor characteristics were investigated. Doping the p-type CuO with both acceptor and isovalent dopants greatly improved the hydrogen sensitivity. The sensitivity of pure heterocontact observed via I-V measurements was increased from {approx}2.3 to {approx}9.4 with Ni doping. Dopants also enhanced the rectifying characteristics of the heterocontacts. Small amounts of Li addition were shown to decrease the reverse bias (saturation) current to 0.2 mA at a bias level of -5V. No unambiguous trends were observed between the sensitivity, the conductivity, and the density of the samples. Comparing the two phase microstructure to the single phase microstructure there was no dramatic increase in the sensitivity. Kinetic studies also confirmed the improved sensor characteristics with doping. The dopants decreased the response time of the sensor by decreasing the response time of one of the adsorption sites. The n-type ZnO was doped with both acceptor and donor dopants. Li doping resulted in the degradation of the p-n junction and the response time of the sensor. However, the current-voltage behavior of Ga-doped heterocontacts showed the best rectifying

  3. Gas Sensors Based on Ceramic p-n Heterocontacts

    Energy Technology Data Exchange (ETDEWEB)

    Aygun, Seymen Murat [Iowa State Univ., Ames, IA (United States)

    2005-01-01

    Ceramic p-n heterocontacts based on CuO/ZnO were successfully synthesized and a systematic study of their hydrogen sensitivity was conducted. The sensitivity and response rates of CuO/ZnO sensors were studied utilizing current-voltage, current-time, and impedance spectroscopy measurements. The heterocontacts showed well-defined rectifying characteristics and were observed to detect hydrogen via both dc and ac measurements. Surface coverage data were derived from current-time measurements which were then fit to a two-site Langmuir adsorption model quite satisfactorily. The fit suggested that there should be two energetically different adsorption sites in the system. The heterocontacts were doped in an attempt to increase the sensitivity and the response rate of the sensor. First, the effects of doping the p-type (CuO) on the sensor characteristics were investigated. Doping the p-type CuO with both acceptor and isovalent dopants greatly improved the hydrogen sensitivity. The sensitivity of pure heterocontact observed via I-V measurements was increased from ~2.3 to ~9.4 with Ni doping. Dopants also enhanced the rectifying characteristics of the heterocontacts. Small amounts of Li addition were shown to decrease the reverse bias (saturation) current to 0.2 mA at a bias level of -5V. No unambiguous trends were observed between the sensitivity, the conductivity, and the density of the samples. Comparing the two phase microstructure to the single phase microstructure there was no dramatic increase in the sensitivity. Kinetic studies also confirmed the improved sensor characteristics with doping. The dopants decreased the response time of the sensor by decreasing the response time of one of the adsorption sites. The n-type ZnO was doped with both acceptor and donor dopants. Li doping resulted in the degradation of the p-n junction and the response time of the sensor. However, the current-voltage behavior of Ga-doped heterocontacts showed the best rectifying characteristics

  4. A trust-based sensor allocation algorithm in cooperative space search problems

    Science.gov (United States)

    Shen, Dan; Chen, Genshe; Pham, Khanh; Blasch, Erik

    2011-06-01

    Sensor allocation is an important and challenging problem within the field of multi-agent systems. The sensor allocation problem involves deciding how to assign a number of targets or cells to a set of agents according to some allocation protocol. Generally, in order to make efficient allocations, we need to design mechanisms that consider both the task performers' costs for the service and the associated probability of success (POS). In our problem, the costs are the used sensor resource, and the POS is the target tracking performance. Usually, POS may be perceived differently by different agents because they typically have different standards or means of evaluating the performance of their counterparts (other sensors in the search and tracking problem). Given this, we turn to the notion of trust to capture such subjective perceptions. In our approach, we develop a trust model to construct a novel mechanism that motivates sensor agents to limit their greediness or selfishness. Then we model the sensor allocation optimization problem with trust-in-loop negotiation game and solve it using a sub-game perfect equilibrium. Numerical simulations are performed to demonstrate the trust-based sensor allocation algorithm in cooperative space situation awareness (SSA) search problems.

  5. Performance Evaluation of Triangulation Based Range Sensors

    Directory of Open Access Journals (Sweden)

    Monica Bordegoni

    2010-07-01

    Full Text Available The performance of 2D digital imaging systems depends on several factors related with both optical and electronic processing. These concepts have originated standards, which have been conceived for photographic equipment and bi-dimensional scanning systems, and which have been aimed at estimating different parameters such as resolution, noise or dynamic range. Conversely, no standard test protocols currently exist for evaluating the corresponding performances of 3D imaging systems such as laser scanners or pattern projection range cameras. This paper is focused on investigating experimental processes for evaluating some critical parameters of 3D equipment, by extending the concepts defined by the ISO standards to the 3D domain. The experimental part of this work concerns the characterization of different range sensors through the extraction of their resolution, accuracy and uncertainty from sets of 3D data acquisitions of specifically designed test objects whose geometrical characteristics are known in advance. The major objective of this contribution is to suggest an easy characterization process for generating a reliable comparison between the performances of different range sensors and to check if a specific piece of equipment is compliant with the expected characteristics.

  6. Microfluidic sensors based on perforated cantilevers

    DEFF Research Database (Denmark)

    Noeth, Nadine-Nicole

    Arbejdet presenteret i denne PhD afhandling omhandler udviklingen af en mikrofluide sensor basered på bjælke teknologi. Bjælkerne er fremstillet i den negative photo-resist SU-8 og i SiN. I bjælkerne er der inkorporeret et array af huller. To nye sensorer er udviklet på baggrund af de perforerede...... bjælker: en yderst sensitiv flow-meter og en partikel tæller med integreret filter funktion. En optisk udlæsningsteknik benyttes til at måle udbøjningen af bjælkerne. En laser stråle fokuseres på enden af bjælken og bjælke forskydningen måles ved at detekterer laser strålens forskydning ved hjælp af en...... strømningsmodstanden de inducerer i kanalen og af hastigheden på væsken i kanalen. Ved at kende geometrien og materiale parametrene kan strømningnshastigheden i kanalen bestemmes ud fra udbøjningen af bjælken. Sensitiviteten på flow-meteret kan varieres ved at ændre på geometrien og bjælke materialet. De perforerede...

  7. A fiber Bragg based semi distributed pressure sensor system for in-vivo vascular applications

    NARCIS (Netherlands)

    Nieuwland, R.A.; Cheng, L.K.; Lemmen, M.H.J.; Oostenbrink, R.H.; Harmsma, P.J.; Schreuder, J.J.

    2014-01-01

    An overview of a fiber Bragg based sensor system, developed for in-vivo vascular pressure and temperature sensing, is presented. The focus is on sensor miniaturization and interrogator optimization to reach a viable sensor system.

  8. Label free optical sensor for Avidin based on single gold nanoparticles functionalized with aptamers.

    Science.gov (United States)

    Hernandez, Frank Jeyson; Dondapati, Srujan Kumar; Ozalp, V Cengiz; Pinto, Alessandro; O'Sullivan, Ciara K; Klar, Thomas A; Katakis, Ioannis

    2009-04-01

    Optical spectroscopy of a single gold nanoparticle, functionalized with an aptamer, is used to sense the specific binding of avidin. Herewith, the field of single noble metal nanoparticle biosensors is extended to the important field of aptamer based assays. The sensitivity of this initial, but not yet optimized apta-nano-sensor is in the range of 20 nM. Due to its nanoscopic size, this single nanoparticle based apta-sensor may be used in nanoscopic volumes such as in array type assays or even inside cells.

  9. An improved sensor for electrochemical microcalorimetry, based on lithiumtantalate

    Science.gov (United States)

    Frittmann, Stefan; Halka, Vadym; Jaramillo, Carlos; Schuster, Rolf

    2015-06-01

    We have developed a pyroelectric sensor for electrochemical microcalorimetry, based on LiTaO3, which provides unprecedented sensitivity for the detection of electrochemically induced heat effects. Deterioration of the heat signal by electrostriction effects on the electrode surface is suppressed by a multilayered construction, where an intermediate sapphire sheet dampens mechanical deformations. Thus, well textured thin metal films become viable candidates as electrodes. We demonstrate the sensor performance for Cu underpotential deposition on (111)-textured Au films on sapphire. The sensor signal compares well with a purely thermal signal induced by heating with laser pulses. The high sensitivity of the sensor is demonstrated by measuring heat effects upon double layer charging in perchloric acid, i.e., in the absence of electrochemical charge- or ion-transfer reactions.

  10. A Microring Resonator Based Negative Permeability Metamaterial Sensor

    Directory of Open Access Journals (Sweden)

    Yao-Zhong Lan

    2011-08-01

    Full Text Available Metamaterials are artificial multifunctional materials that acquire their material properties from their structure, rather than inheriting them directly from the materials they are composed of, and they may provide novel tools to significantly enhance the sensitivity and resolution of sensors. In this paper, we derive the dispersion relation of a cylindrical dielectric waveguide loaded on a negative permeability metamaterial (NPM layer, and compute the resonant frequencies and electric field distribution of the corresponding Whispering-Gallery-Modes (WGMs. The theoretical resonant frequency and electric field distribution results are in good agreement with the full wave simulation results. We show that the NPM sensor based on a microring resonator possesses higher sensitivity than the traditional microring sensor since with the evanescent wave amplification and the increase of NPM layer thickness, the sensitivity will be greatly increased. This may open a door for designing sensors with specified sensitivity.

  11. Research on Stealthy Headphone Detector Based on Geomagnetic Sensor

    Directory of Open Access Journals (Sweden)

    Liu Ya

    2016-01-01

    Full Text Available A kind of stealth headphone detector based on geomagnetic sensor has been developed to deal with the stealth headphones which are small, extremely stealthy and hard to detect. The U.S. PNI geomagnetic sensor is chosen to obtain magnetic field considering the strong magnetic performance of stealth headphones. The earth’s magnetic field at the geomagnetic sensor is eliminated by difference between two geomagnetic sensors, and then weak variations of magnetic field is detected. STM8S103K2 is chosen as the central controlling chip, which is connected to LED, buzzer and LCD 1602. As shown by the experimental results, the probe is not liable to damage by the magnetic field and the developed device has high sensitivity, low False Positive Rate (FAR and satisfactory reliability.

  12. A Microring Resonator Based Negative Permeability Metamaterial Sensor

    Science.gov (United States)

    Sun, Jun; Huang, Ming; Yang, Jing-Jing; Li, Ting-Hua; Lan, Yao-Zhong

    2011-01-01

    Metamaterials are artificial multifunctional materials that acquire their material properties from their structure, rather than inheriting them directly from the materials they are composed of, and they may provide novel tools to significantly enhance the sensitivity and resolution of sensors. In this paper, we derive the dispersion relation of a cylindrical dielectric waveguide loaded on a negative permeability metamaterial (NPM) layer, and compute the resonant frequencies and electric field distribution of the corresponding Whispering-Gallery-Modes (WGMs). The theoretical resonant frequency and electric field distribution results are in good agreement with the full wave simulation results. We show that the NPM sensor based on a microring resonator possesses higher sensitivity than the traditional microring sensor since with the evanescent wave amplification and the increase of NPM layer thickness, the sensitivity will be greatly increased. This may open a door for designing sensors with specified sensitivity. PMID:22164062

  13. Whitelists Based Multiple Filtering Techniques in SCADA Sensor Networks

    Directory of Open Access Journals (Sweden)

    DongHo Kang

    2014-01-01

    Full Text Available Internet of Things (IoT consists of several tiny devices connected together to form a collaborative computing environment. Recently IoT technologies begin to merge with supervisory control and data acquisition (SCADA sensor networks to more efficiently gather and analyze real-time data from sensors in industrial environments. But SCADA sensor networks are becoming more and more vulnerable to cyber-attacks due to increased connectivity. To safely adopt IoT technologies in the SCADA environments, it is important to improve the security of SCADA sensor networks. In this paper we propose a multiple filtering technique based on whitelists to detect illegitimate packets. Our proposed system detects the traffic of network and application protocol attacks with a set of whitelists collected from normal traffic.

  14. An easily fabricated high performance ionic polymer based sensor network

    Science.gov (United States)

    Zhu, Zicai; Wang, Yanjie; Hu, Xiaopin; Sun, Xiaofei; Chang, Longfei; Lu, Pin

    2016-08-01

    Ionic polymer materials can generate an electrical potential from ion migration under an external force. For traditional ionic polymer metal composite sensors, the output voltage is very small (a few millivolts), and the fabrication process is complex and time-consuming. This letter presents an ionic polymer based network of pressure sensors which is easily and quickly constructed, and which can generate high voltage. A 3 × 3 sensor array was prepared by casting Nafion solution directly over copper wires. Under applied pressure, two different levels of voltage response were observed among the nine nodes in the array. For the group producing the higher level, peak voltages reached as high as 25 mV. Computational stress analysis revealed the physical origin of the different responses. High voltages resulting from the stress concentration and asymmetric structure can be further utilized to modify subsequent designs to improve the performance of similar sensors.

  15. An Architecture for Intelligent Systems Based on Smart Sensors

    Science.gov (United States)

    Schmalzel, John; Figueroa, Fernando; Morris, Jon; Mandayam, Shreekanth; Polikar, Robi

    2004-01-01

    Based on requirements for a next-generation rocket test facility, elements of a prototype Intelligent Rocket Test Facility (IRTF) have been implemented. A key component is distributed smart sensor elements integrated using a knowledgeware environment. One of the specific goals is to imbue sensors with the intelligence needed to perform self diagnosis of health and to participate in a hierarchy of health determination at sensor, process, and system levels. The preliminary results provide the basis for future advanced development and validation using rocket test stand facilities at Stennis Space Center (SSC). We have identified issues important to further development of health-enabled networks, which should be of interest to others working with smart sensors and intelligent health management systems.

  16. Novel carbon dioxide gas sensor based on infrared absorption

    Science.gov (United States)

    Zhang, Guangjun; Lui, Junfang; Yuan, Mei

    2000-08-01

    The feasibility of sensing carbon dioxide with a IR single- beam optical structure is studied, and a novel carbon dioxide gas sensor based on IR absorption is achieved. Applying the Lambert-Beer law and some key techniques such as current stabilization for IR source, using a high-quality IR detector, and data compensation for the influences of ambience temperature and atmosphere total pressure, the sensor can measure carbon dioxide with high precision and efficiency. The mathematical models for providing temperature and pressure compensation for the sensor are established. Moreover the solutions to the models are proposed. Both the models and the solutions to the models are verified via experiments. The sensor possesses the advantages of small volume, light weight, low power consumption, and high reliability. Therefore it can be used in many associated fields, such as environmental protection, processing control, chemical analysis, medical diagnosis, and space environmental and control systems.

  17. A flexible piezoelectric force sensor based on PVDF fabrics

    Science.gov (United States)

    Wang, Y. R.; Zheng, J. M.; Ren, G. Y.; Zhang, P. H.; Xu, C.

    2011-04-01

    Polyvinylidene fluoride (PVDF) film has been widely investigated as a sensor and transducer material due to its high piezo-, pyro- and ferroelectric properties. To activate these properties, PVDF films require a mechanical treatment, stretching or poling. In this paper, we report on a force sensor based on PVDF fabrics with excellent flexibility and breathability, to be used as a specific human-related sensor. PVDF nanofibrous fabrics were prepared by using an electrospinning unit and characterized by means of scanning electron microscopy (SEM), FTIR spectroscopy and x-ray diffraction. Preliminary force sensors have been fabricated and demonstrated excellent sensitivity and response to external mechanical forces. This implies that promising applications can be made for sensing garment pressure, blood pressure, heartbeat rate, respiration rate and accidental impact on the human body.

  18. Affinity sensor based on immobilized molecular imprinted synthetic recognition elements.

    Science.gov (United States)

    Lenain, Pieterjan; De Saeger, Sarah; Mattiasson, Bo; Hedström, Martin

    2015-07-15

    An affinity sensor based on capacitive transduction was developed to detect a model compound, metergoline, in a continuous flow system. This system simulates the monitoring of low-molecular weight organic compounds in natural flowing waters, i.e. rivers and streams. During operation in such scenarios, control of the experimental parameters is not possible, which poses a true analytical challenge. A two-step approach was used to produce a sensor for metergoline. Submicron spherical molecularly imprinted polymers, used as recognition elements, were obtained through emulsion polymerization and subsequently coupled to the sensor surface by electropolymerization. This way, a robust and reusable sensor was obtained that regenerated spontaneously under the natural conditions in a river. Small organic compounds could be analyzed in water without manipulating the binding or regeneration conditions, thereby offering a viable tool for on-site application.

  19. APTAMER-BASED SERRS SENSOR FOR THROMBIN DETECTION

    Energy Technology Data Exchange (ETDEWEB)

    Cho, H; Baker, B R; Wachsmann-Hogiu, S; Pagba, C V; Laurence, T A; Lane, S M; Lee, L P; Tok, J B

    2008-07-02

    We describe an aptamer-based Surface Enhanced Resonance Raman Scattering (SERRS) sensor with high sensitivity, specificity, and stability for the detection of a coagulation protein, human a-thrombin. The sensor achieves high sensitivity and a limit of detection of 100 pM by monitoring the SERRS signal change upon the single step of thrombin binding to immobilized thrombin binding aptamer. The selectivity of the sensor is demonstrated by the specific discrimination of thrombin from other protein analytes. The specific recognition and binding of thrombin by the thrombin binding aptamer is essential to the mechanism of the aptamer-based sensor, as shown through measurements using negative control oligonucleotides. In addition, the sensor can detect 1 nM thrombin in the presence of complex biofluids, such as 10% fetal calf serum, demonstrating that the immobilized, 5{prime}-capped, 3{prime}-capped aptamer is sufficiently robust for clinical diagnostic applications. Furthermore, the proposed sensor may be implemented for multiplexed detection using different aptamer-Raman probe complexes.

  20. Matching sensors to missions using a knowledge-based approach

    Science.gov (United States)

    Preece, Alun; Gomez, Mario; de Mel, Geeth; Vasconcelos, Wamberto; Sleeman, Derek; Colley, Stuart; Pearson, Gavin; Pham, Tien; La Porta, Thomas

    2008-04-01

    Making decisions on how best to utilise limited intelligence, surveillance and reconnaisance (ISR) resources is a key issue in mission planning. This requires judgements about which kinds of available sensors are more or less appropriate for specific ISR tasks in a mission. A methodological approach to addressing this kind of decision problem in the military context is the Missions and Means Framework (MMF), which provides a structured way to analyse a mission in terms of tasks, and assess the effectiveness of various means for accomplishing those tasks. Moreover, the problem can be defined as knowledge-based matchmaking: matching the ISR requirements of tasks to the ISR-providing capabilities of available sensors. In this paper we show how the MMF can be represented formally as an ontology (that is, a specification of a conceptualisation); we also represent knowledge about ISR requirements and sensors, and then use automated reasoning to solve the matchmaking problem. We adopt the Semantic Web approach and the Web Ontology Language (OWL), allowing us to import elements of existing sensor knowledge bases. Our core ontologies use the description logic subset of OWL, providing efficient reasoning. We describe a prototype tool as a proof-of-concept for our approach. We discuss the various kinds of possible sensor-mission matches, both exact and inexact, and how the tool helps mission planners consider alternative choices of sensors.

  1. Vehicle passes detector based on multi-sensor analysis

    Science.gov (United States)

    Bocharov, D.; Sidorchuk, D.; Konovalenko, I.; Koptelov, I.

    2015-02-01

    The study concerned deals with a new approach to the problem of detecting vehicle passes in vision-based automatic vehicle classification system. Essential non-affinity image variations and signals from induction loop are the events that can be considered as detectors of an object presence. We propose several vehicle detection techniques based on image processing and induction loop signal analysis. Also we suggest a combined method based on multi-sensor analysis to improve vehicle detection performance. Experimental results in complex outdoor environments show that the proposed multi-sensor algorithm is effective for vehicles detection.

  2. Optical sensor array platform based on polymer electronic devices

    Science.gov (United States)

    Koetse, Marc M.; Rensing, Peter A.; Sharpe, Ruben B. A.; van Heck, Gert T.; Allard, Bart A. M.; Meulendijks, Nicole N. M. M.; Kruijt, Peter G. M.; Tijdink, Marcel W. W. J.; De Zwart, René M.; Houben, René J.; Enting, Erik; van Veen, Sjaak J. J. F.; Schoo, Herman F. M.

    2007-10-01

    Monitoring of personal wellbeing and optimizing human performance are areas where sensors have only begun to be used. One of the reasons for this is the specific demands that these application areas put on the underlying technology and system properties. In many cases these sensors will be integrated in clothing, be worn on the skin, or may even be placed inside the body. This implies that flexibility and wearability of the systems is essential for their success. Devices based on polymer semiconductors allow for these demands since they can be fabricated with thin film technology. The use of thin film device technology allows for the fabrication of very thin sensors (e.g. integrated in food product packaging), flexible or bendable sensors in wearables, large area/distributed sensors, and intrinsically low-cost applications in disposable products. With thin film device technology a high level of integration can be achieved with parts that analyze signals, process and store data, and interact over a network. Integration of all these functions will inherently lead to better cost/performance ratios, especially if printing and other standard polymer technology such as high precision moulding is applied for the fabrication. In this paper we present an optical transmission sensor array based on polymer semiconductor devices made by thin film technology. The organic devices, light emitting diodes, photodiodes and selective medium chip, are integrated with classic electronic components. Together they form a versatile sensor platform that allows for the quantitative measurement of 100 channels and communicates wireless with a computer. The emphasis is given to the sensor principle, the design, fabrication technology and integration of the thin film devices.

  3. Laser-based sensors for oil spill remote sensing

    Science.gov (United States)

    Brown, Carl E.; Fingas, Mervin F.; Mullin, Joseph V.

    1997-07-01

    Remote sensing is becoming an increasingly important tool for the effective direction of oil spill countermeasures. Cleanup personnel have recognized that remote sensing can increase spill cleanup efficiency. It has long been recognized that there is no one sensor which is capable of detecting oil and related petroleum products in all environments and spill scenarios. There are sensors which possess a wide field-of- view and can therefore be used to map the overall extent of the spill. These sensors, however lack the capability to positively identify oil and related products, especially along complicated beach and shoreline environments where several substrates are present. The laser-based sensors under development by the Emergencies Science Division of Environment Canada are designed to fill specific roles in oil spill response. The scanning laser environmental airborne fluorosensor (SLEAF) is being developed to detect and map oil and related petroleum products in complex marine and shoreline environments where other non-specific sensors experience difficulty. The role of the SLEAF would be to confirm or reject suspected oil contamination sites that have been targeted by the non-specific sensors. This confirmation will release response crews from the time-consuming task of physically inspecting each site, and direct crews to sites that require remediation. The laser ultrasonic remote sensing of oil thickness (LURSOT) sensor will provide an absolute measurement of oil thickness from an airborne platform. There are presently no sensors available, either airborne or in the laboratory which can provide an absolute measurement of oil thickness. This information is necessary for the effective direction of spill countermeasures such as dispersant application and in-situ burning. This paper describes the development of laser-based airborne oil spill remote sensing instrumentation at Environment Canada and identifies the anticipated benefits of the use of this technology

  4. Vision communications based on LED array and imaging sensor

    Science.gov (United States)

    Yoo, Jong-Ho; Jung, Sung-Yoon

    2012-11-01

    In this paper, we propose a brand new communication concept, called as "vision communication" based on LED array and image sensor. This system consists of LED array as a transmitter and digital device which include image sensor such as CCD and CMOS as receiver. In order to transmit data, the proposed communication scheme simultaneously uses the digital image processing and optical wireless communication scheme. Therefore, the cognitive communication scheme is possible with the help of recognition techniques used in vision system. By increasing data rate, our scheme can use LED array consisting of several multi-spectral LEDs. Because arranged each LED can emit multi-spectral optical signal such as visible, infrared and ultraviolet light, the increase of data rate is possible similar to WDM and MIMO skills used in traditional optical and wireless communications. In addition, this multi-spectral capability also makes it possible to avoid the optical noises in communication environment. In our vision communication scheme, the data packet is composed of Sync. data and information data. Sync. data is used to detect the transmitter area and calibrate the distorted image snapshots obtained by image sensor. By making the optical rate of LED array be same with the frame rate (frames per second) of image sensor, we can decode the information data included in each image snapshot based on image processing and optical wireless communication techniques. Through experiment based on practical test bed system, we confirm the feasibility of the proposed vision communications based on LED array and image sensor.

  5. Carbon Nanostructure-Based Field-Effect Transistors for Label-Free Chemical/Biological Sensors

    Directory of Open Access Journals (Sweden)

    PingAn Hu

    2010-05-01

    Full Text Available Over the past decade, electrical detection of chemical and biological species using novel nanostructure-based devices has attracted significant attention for chemical, genomics, biomedical diagnostics, and drug discovery applications. The use of nanostructured devices in chemical/biological sensors in place of conventional sensing technologies has advantages of high sensitivity, low decreased energy consumption and potentially highly miniaturized integration. Owing to their particular structure, excellent electrical properties and high chemical stability, carbon nanotube and graphene based electrical devices have been widely developed for high performance label-free chemical/biological sensors. Here, we review the latest developments of carbon nanostructure-based transistor sensors in ultrasensitive detection of chemical/biological entities, such as poisonous gases, nucleic acids, proteins and cells.

  6. Optical Sensors based on Raman Effects

    DEFF Research Database (Denmark)

    Jernshøj, Kit Drescher

    Formålet med denne afhandling er at give en systematisk og uddybende videnskabelig diskussion af molekylær Raman spredning, som kan danne grundlag for udviklingen af molekylespecifikke optiske sensorer til on-site, ikke-destruktiv måling. Afhandlingen falder i tre dele, to teoriafsnit, hvor første...... data fra denne type eksperimenter betyde et øget informationsindhold til anvendelse i den multivariate analyse. Diskussionen er bygget op omkring tre forskellige typer klassifikationsproblemer, hvor der i den første type sker en perturbering, som resulterer i enten en nedgang i symmetri eller en...... energiopsplitning for den ene molekylære specie ud af to tilstede i en opløsning. I det andet type klassifikationsproblem bygger det øgede informationsindhold på en forskydning af den elektroniske absorption og endelig i det tredje klassifikationsproblem er det en molekylær aggregering, der finder sted. I...

  7. [The Trace Methane Sensor Based on TDLAS-WMS].

    Science.gov (United States)

    Liu, Yang; Wu, Jia-nan; Chen, Mei-mei; Yang, Xin-hua; Chen, Chen

    2016-01-01

    Methane is a colorless, odorless, flammable and explosive gas, which not only is the cause to induce significant security risk in coal mining operation, but also one of the important greenhouse gases, so the monitoring of methane is extremely critical. A trace methane gas sensor is designed and developed using the combination of tunable diode laser absorption spectroscopy (TDLAS) and wavelength modulation spectroscopy (WMS) detection technology, which is based on the methane R(3) absorption branch in 2v3 second harmonic band. Through tuning parameters -0.591 cm(-1) x K(-1), using the method that change the working temperature of distributed feedback (DFB) laser to obtain the best absorption wavelength of methane at 1.654 μm. When the mid-wavelength of DFB laser is selected, the appropriate emitting intension can be obtained via adjusting the amplitude of inject current of DFB laser. Meanwhile, combining the frequency modulation technology to move the bandwidth of detection signal from low frequency to high frequency to reduce the 1/f noise. With aspect to the optical structure, utilizing herriott cell with 76 m effective optical path to guarantee the detection of trace methane is successful. Utilizing the proposed trace methane sensor to extract the second harmonic signal of detected methane in the range of 50 to 5 000 μmol x mol(-1), and adopting minimum mean square error criterion to fit the relationship between methane concentration and signal noise ratio, harmonic peak signal and methane concentration, respectively. In addition, the minimum detection limit is 1.4 μmol x mol(-1). The experiment results show the symmetry of harmonic waveform is good, no intensity modulation, and the factor of intensity-modulated impacts on harmonic detection is eliminated.

  8. Aptamer based electrochemical sensors for emerging environmental pollutants

    Directory of Open Access Journals (Sweden)

    Akhtar eHAYAT

    2014-06-01

    Full Text Available Environmental contaminants monitoring is one of the key issues in understanding and managing hazards to human health and ecosystems. In this context, aptamer based electrochemical sensors have achieved intense significance because of their capability to resolve a potentially large number of problems and challenges in environmental contamination. An aptasensor is a compact analytical device incorporating an aptamer (oligonulceotide as the sensing element either integrated within or intimately associated with a physiochemical transducer surface. Nucleic acid is well known for the function of carrying and passing genetic information, however, it has found a key role in analytical monitoring during recent years. Aptamer based sensors represent a novelty in environmental analytical science and there are great expectations for their promising performance as alternative to conventional analytical tools. This review paper focuses on the recent advances in the development of aptamer based electrochemical sensors for environmental applications with special emphasis on emerging pollutants.

  9. Aptamer based electrochemical sensors for emerging environmental pollutants

    Science.gov (United States)

    Hayat, Akhtar; Marty, Jean Louis

    2014-06-01

    Environmental contaminants monitoring is one of the key issues in understanding and managing hazards to human health and ecosystems. In this context, aptamer based electrochemical sensors have achieved intense significance because of their capability to resolve a potentially large number of problems and challenges in environmental contamination. An aptasensor is a compact analytical device incorporating an aptamer (oligonulceotide) as the sensing element either integrated within or intimately associated with a physiochemical transducer surface. Nucleic acid is well known for the function of carrying and passing genetic information, however, it has found a key role in analytical monitoring during recent years. Aptamer based sensors represent a novelty in environmental analytical science and there are great expectations for their promising performance as alternative to conventional analytical tools. This review paper focuses on the recent advances in the development of aptamer based electrochemical sensors for environmental applications with special emphasis on emerging pollutants.

  10. RKP based secure tracking in wireless sensor networks

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    To enhancing the wireless sensor network's security in target tracking and locating application,this article proposes a tracking cluster based mobile cluster distributed group rekeying protocol (MCDGR).Based on the given sensitivity,sensors can locate the moving object in the monitored area and form a tracking cluster around it.This tracking cluster can follow the target logically,process data on the target and report to the sink node,and thus achieve the tracking function.We introduce a multi-path reinforcement scheme,q-composition scheme and one-way cryptographic hash function based random key predietribution algorithm (RKP),which can guarantee a high accuracy and security and a low energy consumption on the same time in large-scale sensor networks.

  11. A novel symmetrical microwave power sensor based on MEMS technology

    Institute of Scientific and Technical Information of China (English)

    Wang Debo; Liao Xiaoping

    2009-01-01

    A novel symmetrical microwave power sensor based on MEMS technology is presented. In this power sensor, the left section inputs the microwave power, while the right section inputs the DC power. Because of its symmetrical structure, this power sensor provides more accurate microwave power measurement capability without mismatch uncertainty and temperature drift. The loss caused by the microwave signal is simulated in this power sensor. This power sensor is designed and fabricated using GaAs MMIC technology. And it is measured in the frequency range up to 20 GHz with an input power in the 0-80 mW range. Over the 80 mW dynamic range, the sensitivity can achieve about 0.2 mV/mW. The difference between the input power in the two sections is below 0.1% for an equal output voltage. In short, the key aspect of this power sensor is that the microwave power measurement is replaced with a DC power measurement.

  12. Probing the kinetics of quantum dot-based proteolytic sensors.

    Science.gov (United States)

    Díaz, Sebastián A; Malonoski, Anthony P; Susumu, Kimihiro; Hofele, Romina V; Oh, Eunkeu; Medintz, Igor L

    2015-09-01

    As an enzyme superfamily, proteases are rivaled only by kinases in terms of their abundance within the human genome. Two ratiometric quantum dot (QD) Förster resonance energy transfer-based sensors designed to monitor the activity of the proteolytic enzymes collagenase and elastase are investigated here. Given the unique material constraints of these sensing constructs, assays are realized utilizing excess enzyme and fixed substrate in progress curve format to yield enzyme specificity or k cat/K m ratios. The range of k cat/Km values derived is 0.5-1.1 mM(-1) s(-1) for the collagenase sensor and 3.7-4.2 mM(-1) s(-1) for the elastase sensor. Of greater interest is the observation that the elastase sensor can be well represented by the Michaelis-Menten model while the collagenase sensor cannot. The latter demonstrates increased specificity at higher peptide substrate/QD loading values and an apparent QD-caused reversible inhibition as the reaction progresses. Understanding the detailed kinetic mechanisms that underpin these types of sensors will be important especially for their further quantitative utilization.

  13. Resonant Magnetic Field Sensors Based On MEMS Technology

    Science.gov (United States)

    Herrera-May, Agustín L.; Aguilera-Cortés, Luz A.; García-Ramírez, Pedro J.; Manjarrez, Elías

    2009-01-01

    Microelectromechanical systems (MEMS) technology allows the integration of magnetic field sensors with electronic components, which presents important advantages such as small size, light weight, minimum power consumption, low cost, better sensitivity and high resolution. We present a discussion and review of resonant magnetic field sensors based on MEMS technology. In practice, these sensors exploit the Lorentz force in order to detect external magnetic fields through the displacement of resonant structures, which are measured with optical, capacitive, and piezoresistive sensing techniques. From these, the optical sensing presents immunity to electromagnetic interference (EMI) and reduces the read-out electronic complexity. Moreover, piezoresistive sensing requires an easy fabrication process as well as a standard packaging. A description of the operation mechanisms, advantages and drawbacks of each sensor is considered. MEMS magnetic field sensors are a potential alternative for numerous applications, including the automotive industry, military, medical, telecommunications, oceanographic, spatial, and environment science. In addition, future markets will need the development of several sensors on a single chip for measuring different parameters such as the magnetic field, pressure, temperature and acceleration. PMID:22408480

  14. Illicit material detector based on gas sensors and neural networks

    Science.gov (United States)

    Grimaldi, Vincent; Politano, Jean-Luc

    1997-02-01

    In accordance with its missions, le Centre de Recherches et d'Etudes de la Logistique de la Police Nationale francaise (CREL) has been conducting research for the past few years targeted at detecting drugs and explosives. We have focused our approach of the underlying physical and chemical detection principles on solid state gas sensors, in the hope of developing a hand-held drugs and explosives detector. The CREL and Laboratory and Scientific Services Directorate are research partners for this project. Using generic hydrocarbon, industrially available, metal oxide sensors as illicit material detectors, requires usage precautions. Indeed, neither the product's concentrations, nor even the products themselves, belong to the intended usage specifications. Therefore, the CREL is currently investigating two major research topics: controlling the sensor's environment: with environmental control we improve the detection of small product concentration; determining detection thresholds: both drugs and explosives disseminate low gas concentration. We are attempting to quantify the minimal concentration which triggers detection. In the long run, we foresee a computer-based tool likely to detect a target gas in a noisy atmosphere. A neural network is the suitable tool for interpreting the response of heterogeneous sensor matrix. This information processing structure, alongside with proper sensor environment control, will lessen the repercussions of common MOS sensor sensitivity characteristic dispersion.

  15. Ionic Liquid based polymer electrolytes for electrochemical sensors

    Directory of Open Access Journals (Sweden)

    Jakub Altšmíd

    2015-09-01

    Full Text Available Amperometric NO2 printed sensor with a new type of solid polymer electrolyte and a carbon working electrode has been developed. The electrolytes based on 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonylimide [EMIM][N(Tf2], 1-butyl-3-methylimidazolium trifluoromethanesulfonate [BMIM][CF3SO3] and 1-ethyl-3-methylimidazolium tetrafluoroborate [EMIM][BF4] ionic liquids were immobilized in poly(vinylidene fluoride matrix [PVDF]. The analyte, gaseous nitrogen dioxide, was detected by reduction at -500 mV vs. platinum pseudoreference electrode. The sensors showed a linear behavior in the whole tested range, i.e., 0 - 5 ppm and their sensitivities were in order of 0.3 x∙10-6 A/ppm. The sensor sensitivity was influenced by the electric conductivity of printing formulation; the higher the conductivity, the higher the sensor sensitivity. The rise/recovery times were in order of tens of seconds. The use of  screen printing technology and platinum pseudoreference electrode simplify the sensor fabrication and it does not have any negative effect on the sensor stability.DOI: http://dx.doi.org/10.5755/j01.ms.21.3.7371

  16. Sensor-based navigation of air duct inspection mobile robots

    Science.gov (United States)

    Koh, Kyoungchul; Choi, H. J.; Kim, Jae-Seon; Ko, Kuk Won; Cho, Hyungsuck

    2001-02-01

    12 This paper deals with an image sensor system and its position estimation algorithm for autonomous duct cleaning and inspection mobile robots. For the real application, a hierarchical control structure that consists of robot motion controller and image sensor system is designed considering the efficient and autonomous motion behaviors in narrow space such as air ducts. The sensor's system consists of a CCD camera and two laser sources to generate slit beams. The image of the structured lights is used for calculating the geometric parameters of the air ducts which are usually designed with a rectangular section. With the acquired 3D information about the environment, the mobile robot with two differential driving wheels is able to autonomously navigates along the duct path without any human intervention. For real time navigation, the relative position estimation of the robot are performed from 3D image reconstructed by the sensor system. The calibration and image processing methods used for the sensor system are presented with the experimental data. The experimental results show the possibility of the sensor based navigation which is important for effective duct cleaning by small mobile robots.

  17. A bionic camera-based polarization navigation sensor.

    Science.gov (United States)

    Wang, Daobin; Liang, Huawei; Zhu, Hui; Zhang, Shuai

    2014-07-21

    Navigation and positioning technology is closely related to our routine life activities, from travel to aerospace. Recently it has been found that Cataglyphis (a kind of desert ant) is able to detect the polarization direction of skylight and navigate according to this information. This paper presents a real-time bionic camera-based polarization navigation sensor. This sensor has two work modes: one is a single-point measurement mode and the other is a multi-point measurement mode. An indoor calibration experiment of the sensor has been done under a beam of standard polarized light. The experiment results show that after noise reduction the accuracy of the sensor can reach up to 0.3256°. It is also compared with GPS and INS (Inertial Navigation System) in the single-point measurement mode through an outdoor experiment. Through time compensation and location compensation, the sensor can be a useful alternative to GPS and INS. In addition, the sensor also can measure the polarization distribution pattern when it works in multi-point measurement mode.

  18. Adaptive inferential sensors based on evolving fuzzy models.

    Science.gov (United States)

    Angelov, Plamen; Kordon, Arthur

    2010-04-01

    A new technique to the design and use of inferential sensors in the process industry is proposed in this paper, which is based on the recently introduced concept of evolving fuzzy models (EFMs). They address the challenge that the modern process industry faces today, namely, to develop such adaptive and self-calibrating online inferential sensors that reduce the maintenance costs while keeping the high precision and interpretability/transparency. The proposed new methodology makes possible inferential sensors to recalibrate automatically, which reduces significantly the life-cycle efforts for their maintenance. This is achieved by the adaptive and flexible open-structure EFM used. The novelty of this paper lies in the following: (1) the overall concept of inferential sensors with evolving and self-developing structure from the data streams; (2) the new methodology for online automatic selection of input variables that are most relevant for the prediction; (3) the technique to detect automatically a shift in the data pattern using the age of the clusters (and fuzzy rules); (4) the online standardization technique used by the learning procedure of the evolving model; and (5) the application of this innovative approach to several real-life industrial processes from the chemical industry (evolving inferential sensors, namely, eSensors, were used for predicting the chemical properties of different products in The Dow Chemical Company, Freeport, TX). It should be noted, however, that the methodology and conclusions of this paper are valid for the broader area of chemical and process industries in general. The results demonstrate that well-interpretable and with-simple-structure inferential sensors can automatically be designed from the data stream in real time, which predict various process variables of interest. The proposed approach can be used as a basis for the development of a new generation of adaptive and evolving inferential sensors that can address the

  19. Ligand exchange based paraoxon imprınted QCM sensor.

    Science.gov (United States)

    Özkütük, Ebru Birlik; Diltemiz, Sibel Emir; Özalp, Elif; Say, Rıdvan; Ersöz, Arzu

    2013-03-01

    In the present work, a paraoxon imprinted QCM sensor has been developed for the determination of paraoxon based on the modification of paraoxon imprinted film onto a quartz crystal combining the advantages of high selectivity of the piezoelectric microgravimetry using MIP film technique and high sensitivity of QCM detection. The paraoxon selective memories have formed on QCM electrode surface by using a new metal-chelate interaction based on pre-organized monomer and the paraoxon recognition activity of these molecular memories was investigated. Molecular imprinted polymer (MIP) film for the detection of paraoxon was developed and the analytical performance of paraoxon imprinted sensor was studied. The molecular imprinted polymer were characterized by FTIR measurements. Paraoxon imprinted sensor was characterized with AFM and ellipsometer. The study also includes the measurement of binding interaction of paraoxon imprinted quartz crystal microbalance (QCM) sensor, selectivity experiments and analytical performance of QCM electrode. The detection limit and the affinity constant (K(affinity)) were found to be 0.06 μM and 2.25 × 10(4) M(-1) for paraoxon [MAAP-Cu(II)-paraoxon] based thin film, respectively. Also, it has been observed that the selectivity of the prepared paraoxon imprinted sensor is high compared to a similar chemical structure which is parathion.

  20. SiC-Based Schottky Diode Gas Sensors

    Science.gov (United States)

    Hunter, Gary W.; Neudeck, Philip G.; Chen, Liang-Yu; Knight, Dak; Liu, Chung-Chiun; Wu, Quing-Hai

    1997-01-01

    Silicon carbide based Schottky diode gas sensors are being developed for high temperature applications such as emission measurements. Two different types of gas sensitive diodes will be discussed in this paper. By varying the structure of the diode, one can affect the diode stability as well as the diode sensitivity to various gases. It is concluded that the ability of SiC to operate as a high temperature semiconductor significantly enhances the versatility of the Schottky diode gas sensing structure and will potentially allow the fabrication of a SiC-based gas sensor arrays for versatile high temperature gas sensing applications.

  1. Robust signals from a quantum-based magnetic compass sensor

    CERN Document Server

    Procopio, Maria

    2013-01-01

    A quantum-based magnetic compass sensor, mediated through radical pair reactions, has been suggested to underlie the sensory ability of migrating birds to receive directional information from the geomagnetic field. Here we extend the currently available models by considering the effects of slow fluctuations in the nuclear spin environment on the directional signal. We quantitatively evaluate the robustness of signals under fluctuations on a timescale longer than the lifetime of a radical pair, utilizing two models of radical pairs. Our results suggest design principles for building a radical-pair based compass sensor that is both robust and highly directional sensitive.

  2. A sensor-based motion planner:Situated-Bug

    Institute of Scientific and Technical Information of China (English)

    居鹤华; 崔平远; 崔祜涛

    2003-01-01

    Propose a new sensor-based motion planning approach of Situated-Bug, which is composed of goal-oriented behavior, boundary following behavior and goal-oriented obstacle avoidance behavior, which are based on fuzzy control. The situated-Bug selects its behaviors according to robot orientation, instead of positions and hit points like other Bug algorithms, and its convergence proves robust to sensor noise, and it can guide the robots running for long rang traverse. At the same time, the design of the Situated-Bug is presented. Simulation results show that the approach is effective and practical.

  3. Open-path, quantum cascade laser-based sensor for high resolution atmospheric ammonia measurements

    Directory of Open Access Journals (Sweden)

    D. J. Miller

    2013-07-01

    Full Text Available We demonstrate a compact, open-path, quantum cascade laser-based atmospheric ammonia sensor operating at 9.06 μm for high sensitivity, high temporal resolution, ground-based measurements. Atmospheric ammonia (NH3 is a gas-phase precursor to fine particulate matter, with implications for air quality and climate change. Currently, NH3 sensing challenges have led to a lack of widespread in-situ measurements. Our open-path sensor configuration avoids sampling artifacts associated with NH3 surface adsorption onto inlet tubing and reduced pressure sampling cells, as well as condensed-phase partitioning ambiguities. Multi-harmonic wavelength modulation spectroscopy allows for selective and sensitive detection of atmospheric-pressure broadened absorption features. An in-line ethylene reference cell provides real-time calibration (±20% accuracy and normalization for instrument drift under rapidly changing field conditions. The sensor has a sensitivity and minimum detection limit of 0.15 ppbv NH3 at 10 Hz, a mass of ~ 5 kg and consumes ~ 50 W of electrical power. In-situ field performance of this open-path NH3 sensor is demonstrated, with 10 Hz time resolution and a large dynamic response for in-situ NH3 measurements. This sensor provides the capabilities for improved in-situ gas phase NH3 sensing relevant for emission source characterization and flux measurements.

  4. Validation of Underwater Sensor Package Using Feature Based SLAM.

    Science.gov (United States)

    Cain, Christopher; Leonessa, Alexander

    2016-03-17

    Robotic vehicles working in new, unexplored environments must be able to locate themselves in the environment while constructing a picture of the objects in the environment that could act as obstacles that would prevent the vehicles from completing their desired tasks. In enclosed environments, underwater range sensors based off of acoustics suffer performance issues due to reflections. Additionally, their relatively high cost make them less than ideal for usage on low cost vehicles designed to be used underwater. In this paper we propose a sensor package composed of a downward facing camera, which is used to perform feature tracking based visual odometry, and a custom vision-based two dimensional rangefinder that can be used on low cost underwater unmanned vehicles. In order to examine the performance of this sensor package in a SLAM framework, experimental tests are performed using an unmanned ground vehicle and two feature based SLAM algorithms, the extended Kalman filter based approach and the Rao-Blackwellized, particle filter based approach, to validate the sensor package.

  5. Validation of Underwater Sensor Package Using Feature Based SLAM

    Directory of Open Access Journals (Sweden)

    Christopher Cain

    2016-03-01

    Full Text Available Robotic vehicles working in new, unexplored environments must be able to locate themselves in the environment while constructing a picture of the objects in the environment that could act as obstacles that would prevent the vehicles from completing their desired tasks. In enclosed environments, underwater range sensors based off of acoustics suffer performance issues due to reflections. Additionally, their relatively high cost make them less than ideal for usage on low cost vehicles designed to be used underwater. In this paper we propose a sensor package composed of a downward facing camera, which is used to perform feature tracking based visual odometry, and a custom vision-based two dimensional rangefinder that can be used on low cost underwater unmanned vehicles. In order to examine the performance of this sensor package in a SLAM framework, experimental tests are performed using an unmanned ground vehicle and two feature based SLAM algorithms, the extended Kalman filter based approach and the Rao-Blackwellized, particle filter based approach, to validate the sensor package.

  6. Analysing surface plasmon resonance phase sensor based on Mach-Zehnder interferometer technique using glycerin

    Science.gov (United States)

    Kashif, Muhammad; Bakar, A. Ashrif A.; Hashim, Fazida Hanim

    2016-12-01

    Surface Plasmon Resonance (SPR) based on Mach-Zehnder interferometer (MZI) is a very accurate tool for the detection and analysis of molecular interactions. The performance of the proposed SPR phase sensor is dependent upon multiple performance parameters that include sensitivity, repeatability, drift and the induction speed of fluid into the flow cell. The SPR Mach-Zehnder interferometer is tested for different glycerin-water concentrations to check its performance based on the different parameters. This paper highlights the enhancement of the performance of SPR phase technique based on MZI that is influenced by different parameters, measured using glycerin solutions. These four performance parameters can affect the performance of SPR based on MZI and have a particular impact on the sensor output. It also provides us information about suitable working conditions for the SPR Mach-Zehnder interferometer sensor. The experiment data shows that the sensor's sensitivity is high for small concentrations of glycerin-water mixtures. Also, any change in drift as well as in induction speed of fluid can affect the performance of SPR Mach-Zehnder interferometer. The sensitivity of SPR phase sensor is high as it can measure glycerin concentration as low as 0.05%.

  7. Field comparison of optical and clark cell dissolved-oxygen sensors

    Science.gov (United States)

    Fulford, J.M.; Davies, W.J.; Garcia, L.

    2005-01-01

    Three multi-parameter water-quality monitors equipped with either Clark cell type or optical type dissolved-oxygen sensors were deployed for 30 days in a brackish (salinity biofouling. The dissolved-oxygen sensors compared periodically to a hand-held dissolved oxygen sensor, but were not serviced or cleaned during the deployment. One of the Clark cell sensors and the optical sensor performed similarly during the deployment. The remaining Clark cell sensor was not aged correctly prior to deployment and did not perform as well as the other sensors. All sensors experienced substantial biofouling that gradually degraded the accuracy of the dissolved-oxygen measurement during the last half of the deployment period. Copyright ASCE 2005.

  8. Colorimetric Sensor Arrays System Based on FPGA for Image Recognition

    Institute of Scientific and Technical Information of China (English)

    Rui Chen; Jian-Hua Xu; Ya-Dong Jiang

    2009-01-01

    A FPGA-based image recognition system is designed for colorimetric sensor array in order to recognize a wide range of volatile organic compounds. The gas molecule is detected by the responsive sensor array and the responsive image is obtained. The image is decomposed to RGB color components using CMOS image sensor. An embedded image recognition archi- tecture based on Xilinx Spartan-3 FPGA is designed to implement the algorithms of image recognition. The algorithm of color coherence vector is discussed in detail[X1] compared with the algorithm of color histograms, and experimental results demonstrate that both of the two algorithms could be analyzed effectively to represent different volatile organic compounds according to their different responsive images in this system.

  9. Vision Based Navigation Sensors for Spacecraft Rendezvous and Docking

    DEFF Research Database (Denmark)

    Benn, Mathias

    . Denmark has, with DTUs design of the Swarm mission, ESAs next Earth Observation Programme magnetic mapping mission, and DTUs participation in GRACE, ELISA and Alsat2, a leading role in designing and verifying sensor systems for this new class of spacecraft. The Swedish led PRISMA mission...... is a technological demonstration mission, where all aspects of space rendezvous and docking to both a cooperative and a non-cooperative target is researched, with the use of novel methods, instruments and technologies. Amongst other equipment, DTU has delivered a vision based sensor package to the Main spacecraft...... of this constellation, providing both position and pose information for the Target vehicle. This dissertation will describe the study, implementation and verification methods that has led to the realization of this optical Vision Based Sensor (VBS), which is used on the PRISMA mission. On June 15th 2010 the PRISMA...

  10. QCM Sensors Based on PEI Films for CO2Detection

    Institute of Scientific and Technical Information of China (English)

    Guang-Zhong Xie; Ting Kang; Yong Zhou; Tao Xie; Hui-Ling Tai; Ya-Dong Jiang

    2015-01-01

    In this paper, quartz crystal microbalance (QCM) gas sensors coated with polyehtyleneimine (PEI) was utilized for carbon dioxide (CO2) detection. The sensing mechanism is based on the availability of reversible acid-base reactions between CO2 molecules and PEI at room temperature. The experimental results revealed that the PEI/starch sensor exhibited much higher sensitivity than that of pure PEI, and showed approximate linearity over a concentration region ranging from 500ppm to 8000ppm. The influence of humidity had also been investigated. Furthermore, the response and recovery time deceased as the operation temperatures increased. Finally, sensitivity loss after conservation for several days and reversibility of the sensors had been discussed.

  11. Lab-on-Chip Cytometry Based on Magnetoresistive Sensors for Bacteria Detection in Milk

    Directory of Open Access Journals (Sweden)

    Ana C. Fernandes

    2014-08-01

    Full Text Available Flow cytometers have been optimized for use in portable platforms, where cell separation, identification and counting can be achieved in a compact and modular format. This feature can be combined with magnetic detection, where magnetoresistive sensors can be integrated within microfluidic channels to detect magnetically labelled cells. This work describes a platform for in-flow detection of magnetically labelled cells with a magneto-resistive based cell cytometer. In particular, we present an example for the validation of the platform as a magnetic counter that identifies and quantifies Streptococcus agalactiae in milk.

  12. Fluorescence-lifetime-based sensors using inhomogeneous waveguiding

    Science.gov (United States)

    Draxler, Sonja; Kieslinger, Dietmar; Trznadel, Karolina; Lippitsch, Max E.

    1996-12-01

    Most intrinsic fiberoptic sensors are based on the evanescent-wave scheme, where the evanescent field of modes guided in a fiber reaches out into a chemically sensitive coating. In the commonly used multimode waveguides, the evanescent field contains only a small part of the total energy, however, thus making evanescent-wave sensors rather insensitive. Combining a transparent substrate and a transparent sensing layer of rather similar refractive index into a common waveguiding structure produces an inhomogeneous waveguide, where a large portion of the total energy transverses the sensing layer. This yields much superior sensor performance. The transmission through a waveguide is subject to various disturbing influences. Thus it is advantageous to combine the inhomogeneous waveguiding approach with a measuring scheme that is not prone to those disturbances. Such a scheme is available with fluorescence lifetime-based sensors. The fluorescence lifetime of an indicator incorporated into the sensing layer is changed by the presence of the respective analyte. This lifetime is independent of the transmission through the waveguide. Thus inhomogeneous waveguiding together with fluorescence lifetime measurement paves the way for optical chemical sensors with high analyte sensitivity and immunity to external disturbances.

  13. Carbon Nanotube Based Chemical Sensors for Space and Terrestrial Applications

    Science.gov (United States)

    Li, Jing; Lu, Yijiang

    2009-01-01

    A nanosensor technology has been developed using nanostructures, such as single walled carbon nanotubes (SWNTs), on a pair of interdigitated electrodes (IDE) processed with a silicon-based microfabrication and micromachining technique. The IDE fingers were fabricated using photolithography and thin film metallization techniques. Both in-situ growth of nanostructure materials and casting of the nanostructure dispersions were used to make chemical sensing devices. These sensors have been exposed to nitrogen dioxide, acetone, benzene, nitrotoluene, chlorine, and ammonia in the concentration range of ppm to ppb at room temperature. The electronic molecular sensing of carbon nanotubes in our sensor platform can be understood by intra- and inter-tube electron modulation in terms of charge transfer mechanisms. As a result of the charge transfer, the conductance of p-type or hole-richer SWNTs in air will change. Due to the large surface area, low surface energy barrier and high thermal and mechanical stability, nanostructured chemical sensors potentially can offer higher sensitivity, lower power consumption and better robustness than the state-of-the-art systems, which make them more attractive for defense and space applications. Combined with MEMS technology, light weight and compact size sensors can be made in wafer scale with low cost. Additionally, a wireless capability of such a sensor chip can be used for networked mobile and fixed-site detection and warning systems for military bases, facilities and battlefield areas.

  14. High performance liquid-level sensor based on mPOFBG for aircraft applications

    DEFF Research Database (Denmark)

    Marques, C. A. F.; Pospori, A.; Saez-Rodriguez, D.

    2015-01-01

    A high performance liquid-level sensor based on microstructured polymer optical fiber Bragg grating (mPOFBG) array sensors is reported in detail. The sensor sensitivity is found to be 98pm/cm of liquid, enhanced by more than a factor of 9 compared to a reported silica fiber-based sensor....

  15. Conductive polymer-based sensors for biomedical applications.

    Science.gov (United States)

    Nambiar, Shruti; Yeow, John T W

    2011-01-15

    A class of organic polymers, known as conducting polymers (CPs), has become increasingly popular due to its unique electrical and optical properties. Material characteristics of CPs are similar to those of some metals and inorganic semiconductors, while retaining polymer properties such as flexibility, and ease of processing and synthesis, generally associated with conventional polymers. Owing to these characteristics, research efforts in CPs have gained significant traction to produce several types of CPs since its discovery four decades ago. CPs are often categorised into different types based on the type of electric charges (e.g., delocalized pi electrons, ions, or conductive nanomaterials) responsible for conduction. Several CPs are known to interact with biological samples while maintaining good biocompatibility and hence, they qualify as interesting candidates for use in a numerous biological and medical applications. In this paper, we focus on CP-based sensor elements and the state-of-art of CP-based sensing devices that have potential applications as tools in clinical diagnosis and surgical interventions. Representative applications of CP-based sensors (electrochemical biosensor, tactile sensing 'skins', and thermal sensors) are briefly discussed. Finally, some of the key issues related to CP-based sensors are highlighted.

  16. Development of capacitance-based and impedance-based wireless sensors and sensor nodes for structural health monitoring applications

    Science.gov (United States)

    Mascarenas, David D. L.; Flynn, Eric B.; Todd, Michael D.; Overly, Timothy G.; Farinholt, Kevin M.; Park, Gyuhae; Farrar, Charles R.

    2010-06-01

    A field demonstration of a new and hybrid wireless sensing network paradigm for structural health monitoring (SHM) is presented. In this paradigm, both power and data interrogation commands are conveyed via a mobile agent that is sent to each sensor node to perform individual interrogations, which can alleviate several limitations of traditional sensing networks. This paper will discuss such prototype systems, which will be used to interrogate capacitive-based and impedance-based sensors for SHM applications. The capacitive-based wireless sensor node is specifically built to collect peak displacement measurements. In addition, a wireless sensor node for collecting electromechanical impedance data has also been developed. Both sensor nodes are specifically designed to accept various power sources and to be wirelessly triggered on an as-needed basis so that they can be used for the hybrid sensing network approach. The capabilities of these miniaturized and portable devices are demonstrated in the laboratory and the field, which was performed at the Alamosa Canyon Bridge in southern New Mexico.

  17. Activity Detection of GalNAc Transferases by Protein-Based Fluorescence Sensors In Vivo.

    Science.gov (United States)

    Song, Lina; Bachert, Collin; Linstedt, Adam D

    2016-01-01

    Mucin-type O-glycosylation occurring in the Golgi apparatus is an important protein posttranslational modification initiated by up to 20 GalNAc-transferase isozymes with largely distinct substrate specificities. Regulation of this enzyme family affects a vast array of proteins transiting the secretory pathway and misregulation causes human diseases. Here we describe the use of protein-based fluorescence sensors that traffic in the secretory pathway to monitor GalNAc-transferase activity in living cells. The sensors can either be "pan" or isozyme specific.

  18. Real-time measurements of endogenous CO production from vascular cells using an ultrasensitive laser sensor

    Science.gov (United States)

    Morimoto, Y.; Durante, W.; Lancaster, D. G.; Klattenhoff, J.; Tittel, F. K.

    2001-01-01

    Carbon monoxide (CO) has been implicated as a biological messenger molecule analogous to nitric oxide. A compact gas sensor based on a midinfrared laser absorption spectroscopy was developed for direct and real-time measurement of trace levels (in approximate pmol) of CO release by vascular cells. The midinfrared light is generated by difference frequency mixing of two nearinfrared lasers in a nonlinear optical crystal. A strong infrared absorption line of CO (4.61 microm) is chosen for convenient CO detection without interference from other gas species. The generation of CO from cultured vascular smooth muscle cells was detected every 20 s without any chemical modification to the CO. The sensitivity of the sensor reached 6.9 pmol CO. CO synthesis was measured from untreated control cells (0.25 nmol per 10(7) cells/h), sodium nitroprusside-treated cells (0.29 nmol per 10(7) cells/h), and hemin-treated cells (0.49 nmol per 10(7) cells/h). The sensor also detected decreases in CO production after the addition of the heme oxygenase (HO) inhibitor tin protoporphyrin-IX (from 0.49 to 0.02 nmol per 10(7) cells/h) and increases after the administration of the HO substrate hemin (from 0.27 to 0.64 nmol per 10(7) cells/h). These results demonstrate that midinfrared laser absorption spectroscopy is a useful technique for the noninvasive and real-time detection of trace levels of CO from biological tissues.

  19. Bioanalytical and chemical sensors using living taste, olfactory, and neural cells and tissues: a short review.

    Science.gov (United States)

    Wu, Chunsheng; Lillehoj, Peter B; Wang, Ping

    2015-11-01

    Biosensors utilizing living tissues and cells have recently gained significant attention as functional devices for chemical sensing and biochemical analysis. These devices integrate biological components (i.e. single cells, cell networks, tissues) with micro-electro-mechanical systems (MEMS)-based sensors and transducers. Various types of cells and tissues derived from natural and bioengineered sources have been used as recognition and sensing elements, which are generally characterized by high sensitivity and specificity. This review summarizes the state of the art in tissue- and cell-based biosensing platforms with an emphasis on those using taste, olfactory, and neural cells and tissues. Many of these devices employ unique integration strategies and sensing schemes based on sensitive transducers including microelectrode arrays (MEAs), field effect transistors (FETs), and light-addressable potentiometric sensors (LAPSs). Several groups have coupled these hybrid biosensors with microfluidics which offers added benefits of small sample volumes and enhanced automation. While this technology is currently limited to lab settings due to the limited stability of living biological components, further research to enhance their robustness will enable these devices to be employed in field and clinical settings.

  20. Sensor of hydrostatic pressure based on gallium antimonide microcrystals

    Directory of Open Access Journals (Sweden)

    Druzhinin A. A.

    2015-08-01

    Full Text Available Currently, silicon and germanium, the most common materials in the production of discrete semiconductor devices and integrated circuits, do not always meet all the requirements to the sensing elements of mechanical quantities sensors. Therefore, it is logical to research the properties of other semiconductor materials that could be used as sensing elements in such sensors. A3B5 semiconductor compounds seem promising for such purpose. Effect of hydrostatic pressure up to 5000 bar on the resistance of n-type antimonide gallium whiskers doped by Se or Te was studied. Coefficient of hydrostatic pressure for this crystals was determined, it equals Kh = (16,5—20,0•10–5 bar–1 at 20°N. Temperature dependence of resistance and coefficient Kh for this crystals in the temperature range ±60°N was studied. Design of the developed hydrostatic pressure sensor based on GaSb whiskers and its characteristics are presented. The possibility to decrease the temperature dependence of sensitive element resistance by mounting GaSb whiskers on the substrates fabricated from materials with different temperature coefficient of expansion was examined. It was shown that mounting of GaSb crystals on Cu substrate gives the optimal result, in this case the temperature coefficient decrease to 0,05%•°N–1, that leads to decrease of output temperature dependence. The main advantages of developed pressure sensor are: the simplified design in comparison with pressure sensors with strain gauges mounted on spring elements; the high sensitivity to pressure that is constant in the wide pressure range; the improvement of sensors metrological characteristics owing to hysteresis absence. The possible application fields of developed sensors are measuring of high and extremely high pressure, chemical and oil industries, measuring of pressure in oil bore-holes, investigation of explosive processes.

  1. Single fluorescent protein-based Ca2+ sensors with increased dynamic range

    Directory of Open Access Journals (Sweden)

    Labas Yulii A

    2007-06-01

    Full Text Available Abstract Background Genetically encoded sensors developed on the basis of green fluorescent protein (GFP-like proteins are becoming more and more popular instruments for monitoring cellular analytes and enzyme activities in living cells and transgenic organisms. In particular, a number of Ca2+ sensors have been developed, either based on FRET (Fluorescence Resonance Energy Transfer changes between two GFP-mutants or on the change in fluorescence intensity of a single circularly permuted fluorescent protein (cpFP. Results Here we report significant progress on the development of the latter type of Ca2+ sensors. Derived from the knowledge of previously reported cpFP-based sensors, we generated a set of cpFP-based indicators with different spectral properties and fluorescent responses to changes in Ca2+ concentration. Two variants, named Case12 and Case16, were characterized by particular high brightness and superior dynamic range, up to 12-fold and 16.5-fold increase in green fluorescence between Ca2+-free and Ca2+-saturated forms. We demonstrated the high potential of these sensors on various examples, including monitoring of Ca2+ response to a prolonged glutamate treatment in cortical neurons. Conclusion We believe that expanded dynamic range, high brightness and relatively high pH-stability should make Case12 and Case16 popular research tools both in scientific studies and high throughput screening assays.

  2. Optical refractometric sensors based on embedded nanowire microcoil resonators

    OpenAIRE

    2007-01-01

    We present a novel, robust, and compact refractometric sensor based on a high Q factor embedded nanowire microcoil resonator with an intrinsic fluidic channel. Ideally, sensitivities as high as 1000 nm/RIU and a refractive index resolution of 10 can be achieved.

  3. Demonstration of a refractometric sensor based on optical microfiber resonator

    OpenAIRE

    2008-01-01

    We experimentally demonstrated a refractometric sensor based on a coated optical microfiber coil resonator. It is robust, compact, and comprises an intrinsic fluidic channel. A sensitivity of about 40 nm/RIU (refractive index unit) has been measured, in agreement with predictions.

  4. A displacement sensor of dual-light based on FPGA

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The dual-light displacement sensor is presented to obtain a higher accuracy compared with the single. The structure and principle of the system are also introduced, and the hardware and software are brought in too. The function of the system is feasible through the experiments and simulating the data process based on FPGA.

  5. Durable chemical sensors based on field-effect transistors

    NARCIS (Netherlands)

    Reinhoudt, D.N.

    1995-01-01

    The design of durable chemical sensors based on field-effect transistors (FETs) is described. After modification of an ion-sensitive FET (ISFET) with a polysiloxane membrane matrix, it is possible to attach all electroactive components covalently. Preliminary results of measurements with a sodium-se

  6. SOI based integrated on-chip photonic pressure sensor

    NARCIS (Netherlands)

    Chakkalakkal Abdulla, S.M.C.; Harmsma, P.J.; Nieuwland, R.A.; Pozo Torres, J.M.; Lemmen, M.H.J.; Sadeghian Marnani, H.; Berg, J.H. van den; Bodis, P.

    2012-01-01

    A compact, mass producible Silicon On Insulator (SOI) based pressure sensor consisting of a folded Micro Ring Resonator (MRR) on a circular diaphragm is successfully designed, fabricated and characterized [1-3]. The MRR is designed to be single mode for TE polarized light at 1550 nm. The folded MRR

  7. Coating based Fiber Bragg Grating humidity sensor array

    NARCIS (Netherlands)

    Cheng, L.K.; Boersma, A.; Jansen, T.H.

    2012-01-01

    A coating based FBG humidity sensor is developed for distributed humidity sensing. The sensitivity of the coated FBG is optimized by varying the chemical composition and the thickness of the coating. A sensitivity of ~2 pm/%RH and a rapid response are demonstrated. The composition of the coating can

  8. Connected Dominating Set Based Topology Control in Wireless Sensor Networks

    Science.gov (United States)

    He, Jing

    2012-01-01

    Wireless Sensor Networks (WSNs) are now widely used for monitoring and controlling of systems where human intervention is not desirable or possible. Connected Dominating Sets (CDSs) based topology control in WSNs is one kind of hierarchical method to ensure sufficient coverage while reducing redundant connections in a relatively crowded network.…

  9. Characterization of Integrated Optical Strain Sensors Based on Silicon Waveguides

    NARCIS (Netherlands)

    Westerveld, W.J.; Leinders, S.M.; Muilwijk, P.M.; Pozo, J.

    2013-01-01

    Microscale strain gauges are widely used in micro electro-mechanical systems (MEMS) to measure strains such as those induced by force, acceleration, pressure or sound. We propose all-optical strain sensors based on micro-ring resonators to be integrated with MEMS. We characterized the strain-induced

  10. Condition-Based Maintenance using Sensor Arrays and Telematics

    CERN Document Server

    Palem, Gopalakrishna

    2013-01-01

    Emergence of uniquely addressable embeddable devices has raised the bar on Telematics capabilities. Though the technology itself is not new, its application has been quite limited until now. Sensor based telematics technologies generate volumes of data that are orders of magnitude larger than what operators have dealt with previously. Real-time big data computation capabilities have opened the flood gates for creating new predictive analytics capabilities into an otherwise simple data log systems, enabling real-time control and monitoring to take preventive action in case of any anomalies. Condition-based-maintenance, usage-based-insurance, smart metering and demand-based load generation etc. are some of the predictive analytics use cases for Telematics. This paper presents the approach of condition-based maintenance using real-time sensor monitoring, Telematics and predictive data analytics.

  11. Topology control based on quantum genetic algorithm in sensor networks

    Institute of Scientific and Technical Information of China (English)

    SUN Lijuan; GUO Jian; LU Kai; WANG Ruchuan

    2007-01-01

    Nowadays,two trends appear in the application of sensor networks in which both multi-service and quality of service (QoS)are supported.In terms of the goal of low energy consumption and high connectivity,the control on topology is crucial.The algorithm of topology control based on quantum genetic algorithm in sensor networks is proposed.An advantage of the quantum genetic algorithm over the conventional genetic algorithm is demonstrated in simulation experiments.The goals of high connectivity and low consumption of energy are reached.

  12. Novel gas sensors based on carbon nanotube networks

    Energy Technology Data Exchange (ETDEWEB)

    Sayago, I; Aleixandre, M; Horrillo, M C; Fernandez, M J; Gutierrez, J [Laboratorio de Sensores IFA-CSIC, Serrano 144, 28006 Madrid (Spain); Terrado, E; Lafuente, E; Maser, W K; Benito, A M; Martinez, M T; Munoz, E [Instituto de CarboquImica CSIC, Miguel Luesma Castan 4, 50018 Zaragoza (Spain); Urriolabeitia, E P; Navarro, R [Departamento de Quimica Inorganica, ICMA (Universidad de Zaragoza-CSIC), 50009 Zaragoza (Spain)], E-mail: sayago@ifa.cetef.csic.es, E-mail: edgar@icb.csic.es

    2008-08-15

    Novel resistive gas sensors based on single-walled carbon nanotube (SWNT) networks as the active sensing element nave been investigated for gas detection. SWNTs networks were fabricated by airbrushing on alumina substrates. As-produced- and Pd-decorated SWNT materials were used as sensitive layers for the detection of NO{sub 2} and H{sub 2}, respectively. The studied sensors provided good response to NO{sub 2} and H{sub 2} as well as excellent selectivities to interfering gases.

  13. Distributed optical fiber dynamic magnetic field sensor based on magnetostriction.

    Science.gov (United States)

    Masoudi, Ali; Newson, Trevor P

    2014-05-01

    A distributed optical fiber sensor is introduced which is capable of quantifying multiple magnetic fields along a 1 km sensing fiber with a spatial resolution of 1 m. The operation of the proposed sensor is based on measuring the magnetorestrictive induced strain of a nickel wire attached to an optical fiber. The strain coupled to the optical fiber was detected by measuring the strain-induced phase variation between the backscattered Rayleigh light from two segments of the sensing fiber. A magnetic field intensity resolution of 0.3 G over a bandwidth of 50-5000 Hz was demonstrated.

  14. Carbon Nanotube-Based Structural Health Monitoring Sensors

    Science.gov (United States)

    Wincheski, Russell; Jordan, Jeffrey; Oglesby, Donald; Watkins, Anthony; Patry, JoAnne; Smits, Jan; Williams, Phillip

    2011-01-01

    Carbon nanotube (CNT)-based sensors for structural health monitoring (SHM) can be embedded in structures of all geometries to monitor conditions both inside and at the surface of the structure to continuously sense changes. These CNTs can be manipulated into specific orientations to create small, powerful, and flexible sensors. One of the sensors is a highly flexible sensor for crack growth detection and strain field mapping that features a very dense and highly ordered array of single-walled CNTs. CNT structural health sensors can be mass-produced, are inexpensive, can be packaged in small sizes (0.5 micron(sup 2)), require less power than electronic or piezoelectric transducers, and produce less waste heat per square centimeter than electronic or piezoelectric transducers. Chemically functionalized lithographic patterns are used to deposit and align the CNTs onto metallic electrodes. This method consistently produces aligned CNTs in the defined locations. Using photo- and electron-beam lithography, simple Cr/Au thin-film circuits are patterned onto oxidized silicon substrates. The samples are then re-patterned with a CNT-attracting, self-assembled monolayer of 3-aminopropyltriethoxysilane (APTES) to delineate the desired CNT locations between electrodes. During the deposition of the solution-suspended single- wall CNTs, the application of an electric field to the metallic contacts causes alignment of the CNTs along the field direction. This innovation is a prime candidate for smart skin technologies with applications ranging from military, to aerospace, to private industry.

  15. Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging

    Science.gov (United States)

    Liang, Yizhi; Jin, Long; Wang, Lidai; Bai, Xue; Cheng, Linghao; Guan, Bai-Ou

    2017-01-01

    Photoacoustic imaging, especially for intravascular and endoscopic applications, requires ultrasound probes with miniature size and high sensitivity. In this paper, we present a new photoacoustic sensor based on a small-sized fiber laser. Incident ultrasound waves exert pressures on the optical fiber laser and induce harmonic vibrations of the fiber, which is detected by the frequency shift of the beating signal between the two orthogonal polarization modes in the fiber laser. This ultrasound sensor presents a noise-equivalent pressure of 40 Pa over a 50-MHz bandwidth. We demonstrate this new ultrasound sensor on an optical-resolution photoacoustic microscope. The axial and lateral resolutions are 48 μm and 3.3 μm. The field of view is up to 1.57 mm2. The sensor exhibits strong resistance to environmental perturbations, such as temperature changes, due to common-mode cancellation between the two orthogonal modes. The present fiber laser ultrasound sensor offers a new tool for all-optical photoacoustic imaging.

  16. Gas Sensors Based on Semiconducting Nanowire Field-Effect Transistors

    Directory of Open Access Journals (Sweden)

    Ping Feng

    2014-09-01

    Full Text Available One-dimensional semiconductor nanostructures are unique sensing materials for the fabrication of gas sensors. In this article, gas sensors based on semiconducting nanowire field-effect transistors (FETs are comprehensively reviewed. Individual nanowires or nanowire network films are usually used as the active detecting channels. In these sensors, a third electrode, which serves as the gate, is used to tune the carrier concentration of the nanowires to realize better sensing performance, including sensitivity, selectivity and response time, etc. The FET parameters can be modulated by the presence of the target gases and their change relate closely to the type and concentration of the gas molecules. In addition, extra controls such as metal decoration, local heating and light irradiation can be combined with the gate electrode to tune the nanowire channel and realize more effective gas sensing. With the help of micro-fabrication techniques, these sensors can be integrated into smart systems. Finally, some challenges for the future investigation and application of nanowire field-effect gas sensors are discussed.

  17. Ultrafast response sensor to formaldehyde gas based on metal oxide.

    Science.gov (United States)

    Choi, N-J; Lee, H-K; Moon, S E; Kim, J; Yang, W S

    2014-08-01

    Thick film semiconductor gas sensors based on indium oxide were fabricated on Si substrate. The sensing materials on Si substrate were characterized using optical microscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM), and so on. They were very fine and uniform and we found out that particle sizes were about 20~30 nm through XRD analysis. Gas responses of fabricated sensors were measured in a chamber where gas flow was controlled by mass flow controller (MFC). Their resistance changes were monitored in real time by using data acquisition board and personal computer. Gas response characteristics were examined for formaldehyde (HCHO) gas which was known as the cause of sick building syndrome. Particularly, the sensors showed responses to formaldehyde gas at sub ppm (cf, standard of natural environment in building is about 80 ppb by ministry of environment in Korea), as a function of operating temperatures and gas concentrations. Also, we investigated sensitivity, repetition, selectivity, response speed and reproducibility of the sensors. The lowest detection limit is HCHO 25 ppb and sensitivity at 800 ppb is over 25% at 350 °C operating temperature. The response time (8 s) and recovery time (15 s) to HCHO gas at 200 ppb were very fast compared to other commercial products in flow type measurement condition. Repetition measurement was very good with ±3% in full measurement range. The fabricated metal oxide gas sensor showed good performance to HCHO gas and proved that it could be adaptable to indoor environment in building.

  18. Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging

    Science.gov (United States)

    Liang, Yizhi; Jin, Long; Wang, Lidai; Bai, Xue; Cheng, Linghao; Guan, Bai-Ou

    2017-01-01

    Photoacoustic imaging, especially for intravascular and endoscopic applications, requires ultrasound probes with miniature size and high sensitivity. In this paper, we present a new photoacoustic sensor based on a small-sized fiber laser. Incident ultrasound waves exert pressures on the optical fiber laser and induce harmonic vibrations of the fiber, which is detected by the frequency shift of the beating signal between the two orthogonal polarization modes in the fiber laser. This ultrasound sensor presents a noise-equivalent pressure of 40 Pa over a 50-MHz bandwidth. We demonstrate this new ultrasound sensor on an optical-resolution photoacoustic microscope. The axial and lateral resolutions are 48 μm and 3.3 μm. The field of view is up to 1.57 mm2. The sensor exhibits strong resistance to environmental perturbations, such as temperature changes, due to common-mode cancellation between the two orthogonal modes. The present fiber laser ultrasound sensor offers a new tool for all-optical photoacoustic imaging. PMID:28098201

  19. Silicon nanowires-based fluorescence sensor for Cu(II).

    Science.gov (United States)

    Mu, Lixuan; Shi, Wensheng; Chang, Jack C; Lee, Shuit-Tong

    2008-01-01

    Si nanowires (SiNWs) were covalently modified by fluorescence ligand, N-(quinoline-8-yl)-2-(3-triethoxysilyl-propylamino)-acetamide (QlOEt) and finally formed an optical sensor to realize a highly sensitive and selective detection for Cu(II). The QlOEt-modified SiNWs sensor has sensitivity for Cu(II) down to 10(-8) M, which is more sensitive than QlOEt alone. Metal ions interferences have no observable effect on the sensitivity and selectivity of QlOEt-modified SiNWs sensor. The SiNWs-based fluorescence sensor is reversible by addition of acid to replace Cu(II). The sensing mechanisms of QlOEt-modified SiNWs to Cu(II) and the rationale for the increase in sensitivity and selectivity of QlOEt-modified SiNWs over QlOEt on Cu(II) are discussed. The current sensor structure may be extendable to other chemo- and biosensors, and even to nanosensors for direct detection of specific materials in intracellular environment.

  20. Diaphragm Based Fiber Bragg Grating Acceleration Sensor with Temperature Compensation.

    Science.gov (United States)

    Li, Tianliang; Tan, Yuegang; Han, Xue; Zheng, Kai; Zhou, Zude

    2017-01-23

    A novel fiber Bragg grating (FBG) sensing-based acceleration sensor has been proposed to simultaneously decouple and measure temperature and acceleration in real-time. This design applied a diaphragm structure and utilized the axial property of a tightly suspended optical fiber, enabling improvement in its sensitivity and resonant frequency and achieve a low cross-sensitivity. The theoretical vibrational model of the sensor has been built, and its design parameters and sensing properties have been analyzed through the numerical analysis. A decoupling method has been presented with consideration of the thermal expansion of the sensor structure to realize temperature compensation. Experimental results show that the temperature sensitivity is 8.66 pm/°C within the range of 30-90 °C. The acceleration sensitivity is 20.189 pm/g with a linearity of 0.764% within the range of 5~65 m/s². The corresponding working bandwidth is 10~200 Hz and its resonant frequency is 600 Hz. This sensor possesses an excellent impact resistance for the cross direction, and the cross-axis sensitivity is below 3.31%. This implementation can avoid the FBG-pasting procedure and overcome its associated shortcomings. The performance of the proposed acceleration sensor can be easily adjusted by modifying their corresponding physical parameters to satisfy requirements from different vibration measurements.

  1. Diaphragm Based Fiber Bragg Grating Acceleration Sensor with Temperature Compensation

    Directory of Open Access Journals (Sweden)

    Tianliang Li

    2017-01-01

    Full Text Available A novel fiber Bragg grating (FBG sensing-based acceleration sensor has been proposed to simultaneously decouple and measure temperature and acceleration in real-time. This design applied a diaphragm structure and utilized the axial property of a tightly suspended optical fiber, enabling improvement in its sensitivity and resonant frequency and achieve a low cross-sensitivity. The theoretical vibrational model of the sensor has been built, and its design parameters and sensing properties have been analyzed through the numerical analysis. A decoupling method has been presented with consideration of the thermal expansion of the sensor structure to realize temperature compensation. Experimental results show that the temperature sensitivity is 8.66 pm/°C within the range of 30–90 °C. The acceleration sensitivity is 20.189 pm/g with a linearity of 0.764% within the range of 5~65 m/s2. The corresponding working bandwidth is 10~200 Hz and its resonant frequency is 600 Hz. This sensor possesses an excellent impact resistance for the cross direction, and the cross-axis sensitivity is below 3.31%. This implementation can avoid the FBG-pasting procedure and overcome its associated shortcomings. The performance of the proposed acceleration sensor can be easily adjusted by modifying their corresponding physical parameters to satisfy requirements from different vibration measurements.

  2. Enhanced Sensing Characteristics in MEMS-based Formaldehyde Gas Sensor

    CERN Document Server

    Wang, Yu-Hsiang; Lee, Chia-Yen; Ma, R -H; Chou, Po-Cheng

    2008-01-01

    This study has successfully demonstrated a novel self-heating formaldehyde gas sensor based on a thin film of NiO sensing layer. A new fabrication process has been developed in which the Pt micro heater and electrodes are deposited directly on the substrate and the NiO thin film is deposited above on the micro heater to serve as sensing layer. Pt electrodes are formed below the sensing layer to measure the electrical conductivity changes caused by formaldehyde oxidation at the oxide surface. Furthermore, the upper sensing layer and NiO/Al2O3 co-sputtering significantly increases the sensitivity of the gas sensor, improves its detection limit capability. The microfabricated formaldehyde gas sensor presented in this study is suitable not only for industrial process monitoring, but also for the detection of formaldehyde concentrations in buildings in order to safeguard human health.

  3. A piezopaint-based sensor for monitoring structure dynamics

    Science.gov (United States)

    Lahtinen, R.; Muukkonen, T.; Koskinen, J.; Hannula, S.-P.; Heczko, O.

    2007-12-01

    Piezoceramic materials are used today in a variety of applications. By combining a piezoceramic powder with paint resin it is possible to fabricate a new type of piezomaterial, which can easily be applied to almost any surface. This paper describes the development of such a paint. The thermal stability and sensitivity as a function of frequency were investigated. Furthermore, a sensor based on an optimized epoxy piezopaint having a thickness of 80 µm was fixed on a steel beam of a footbridge to study the performance of the sensor and its long-term stability. It was demonstrated that the sensor could detect signals easily both from bridge movement and from pedestrian traffic on the bridge. The signal remained constant for a period of over thirteen months of monitoring.

  4. Enhanced Voting based Secure Localization for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    M. B. Nirmala

    2015-11-01

    Full Text Available Development of location estimation algorithms with improvement in location precision with lower cost, less energy consumption and less hardware support has become more important for many applications in Wireless Sensor Networks (WSNs. This paper addresses the problem of secure location determination, known as secure localization in WSNs using voting based technique which gives a search region in presence of anchor nodes. From the obtained search region trilateration is applied to know the position of sensor nodes. To avoid the involvement of sensor nodes in further location estimation process, bilateration is applied. Experimental analysis shows that the maximum number of nodes can be localized and accurate location of a node can be determined efficiently with low estimation error. To avoid the attacks and involvement of malicious nodes in the localization process, we implement an improved authentication and security algorithm. Using few location reference points in the localization process reduces the communication cost. The proposed scheme also provides very good localization accuracy.

  5. Optical Sensor Based on a Single CdS Nanobelt

    Directory of Open Access Journals (Sweden)

    Lei Li

    2014-04-01

    Full Text Available In this paper, an optical sensor based on a cadmium sulfide (CdS nanobelt has been developed. The CdS nanobelt was synthesized by the vapor phase transportation (VPT method. X-Ray Diffraction (XRD and Transmission Electron Microscopy (TEM results revealed that the nanobelt had a hexagonal wurtzite structure of CdS and presented good crystal quality. A single nanobelt Schottky contact optical sensor was fabricated by the electron beam lithography (EBL technique, and the device current-voltage results showed back-to-back Schottky diode characteristics. The photosensitivity, dark current and the decay time of the sensor were 4 × 104, 31 ms and 0.2 pA, respectively. The high photosensitivity and the short decay time were because of the exponential dependence of photocurrent on the number of the surface charges and the configuration of the back to back Schottky junctions.

  6. Optical sensor based on a single CdS nanobelt.

    Science.gov (United States)

    Li, Lei; Yang, Shuming; Han, Feng; Wang, Liangjun; Zhang, Xiaotong; Jiang, Zhuangde; Pan, Anlian

    2014-04-23

    In this paper, an optical sensor based on a cadmium sulfide (CdS) nanobelt has been developed. The CdS nanobelt was synthesized by the vapor phase transportation (VPT) method. X-Ray Diffraction (XRD) and Transmission Electron Microscopy (TEM) results revealed that the nanobelt had a hexagonal wurtzite structure of CdS and presented good crystal quality. A single nanobelt Schottky contact optical sensor was fabricated by the electron beam lithography (EBL) technique, and the device current-voltage results showed back-to-back Schottky diode characteristics. The photosensitivity, dark current and the decay time of the sensor were 4 × 10⁴, 31 ms and 0.2 pA, respectively. The high photosensitivity and the short decay time were because of the exponential dependence of photocurrent on the number of the surface charges and the configuration of the back to back Schottky junctions.

  7. Photonic Crystal Fibre SERS Sensors Based on Silver Nanoparticle Colloid

    Institute of Scientific and Technical Information of China (English)

    XIE Zhi-Guo; LU Yong-Hua; WANG Pei; LIN Kai-Qun; YAN Jie; MING Hai

    2008-01-01

    @@ A photonic crystal fibre (PCF) surface enhanced Raman scattering (SERS) sensor is developed based on silver nanoparticle colloid.Analyte solution and silver nanoparticles are injected into the air holes of PCF by a simple modified syringe to overcome maes-transport constraints, allowing more silver nanoparticles involved in SERS activity.This sensor offers significant benefit over the conventional SERS sensor with high flexibility, easy manufacture.We demonstrate the detection of 4-mercaptobenzoic acid (4-MBA ) molecules with the injecting way and the common dipping measurement.The injecting way shows obviously better results than the dipping one.Theoretical analysis indicates that this PCF SERS substrate offers enhancement of about 7 orders of magnitude in SERS active area.

  8. Coumarin Based Neutral Sensor for Biologically Important Anions

    Institute of Scientific and Technical Information of China (English)

    SHAO Jie

    2011-01-01

    A coumarin Shiff-base derivative,salicylaldehyde-N-(6-phenylazo-coumarin-3-formyl)-hydrazone(1),was obtained by simple organic synthesis from cheap and commercially available starting materials.Sensor 1 exhibits a very weak fluorescence emission,however,in the presence of acetate ions “turn-on” fluorescence is observed,which results from binding-induced conformational restriction of the fluorophore.Importantly,sensor 1 can also be used as colorimetric chemosensor for the anions with strong basicity,which is easily observed from yellow to red by naked eyes.Consequently,compound l can behave as a colorimetric and fluorescence sensor for biologically important F,CH3COO and H2PO4- in the presence of the other anions tested such as Cl-,Br- and I- in dimethyl sulfoxide(DMSO).

  9. Space magnetometer based on an anisotropic magnetoresistive hybrid sensor.

    Science.gov (United States)

    Brown, P; Whiteside, B J; Beek, T J; Fox, P; Horbury, T S; Oddy, T M; Archer, M O; Eastwood, J P; Sanz-Hernández, D; Sample, J G; Cupido, E; O'Brien, H; Carr, C M

    2014-12-01

    We report on the design and development of a low resource, dual sensor vector magnetometer for space science applications on very small spacecraft. It is based on a hybrid device combining an orthogonal triad of commercial anisotropic magnetoresistive (AMR) sensors with a totem pole H-Bridge drive on a ceramic substrate. The drive enables AMR operation in the more sensitive flipped mode and this is achieved without the need for current spike transmission down a sensor harness. The magnetometer has sensitivity of better than 3 nT in a 0-10 Hz band and a total mass of 104 g. Three instruments have been launched as part of the TRIO-CINEMA space weather mission, inter-calibration against the International Geomagnetic Reference Field model makes it possible to extract physical signals such as field-aligned current deflections of 20-60 nT within an approximately 45,000 nT ambient field.

  10. A Neuron Model Based Ultralow Current Sensor System for Bioapplications

    Directory of Open Access Journals (Sweden)

    A. K. M. Arifuzzman

    2016-01-01

    Full Text Available An ultralow current sensor system based on the Izhikevich neuron model is presented in this paper. The Izhikevich neuron model has been used for its superior computational efficiency and greater biological plausibility over other well-known neuron spiking models. Of the many biological neuron spiking features, regular spiking, chattering, and neostriatal spiny projection spiking have been reproduced by adjusting the parameters associated with the model at hand. This paper also presents a modified interpretation of the regular spiking feature in which the firing pattern is similar to that of the regular spiking but with improved dynamic range offering. The sensor current ranges between 2 pA and 8 nA and exhibits linearity in the range of 0.9665 to 0.9989 for different spiking features. The efficacy of the sensor system in detecting low amount of current along with its high linearity attribute makes it very suitable for biomedical applications.

  11. Pressure sensor based on flexible photonic crystal membrane.

    Science.gov (United States)

    Karrock, Torben; Gerken, Martina

    2015-12-01

    We demonstrate a pressure sensor based on deformation of a periodically nanostructured Bragg grating waveguide on a flexible 50 µm polydimethylsiloxane membrane and remote optical read out. A pressure change causes deformation of this 2 mm diameter photonic crystal membrane sealing a reference volume. The resulting shift of the guided mode resonances is observed by a remote camera as localized color change. Crossed polarization filters are employed for enhancing the visibility of the guided mode resonances. Pressure values are calculated from the intensity change in the green color channel using a calibration curve in the range of 2000 Pa to 4000 Pa. A limit of detection (LOD) of 160 Pa is estimated. This LOD combined with the small size of the sensor and its biocompatibility render it promising for application as an implantable intraocular pressure sensor.

  12. Space magnetometer based on an anisotropic magnetoresistive hybrid sensor

    Science.gov (United States)

    Brown, P.; Whiteside, B. J.; Beek, T. J.; Fox, P.; Horbury, T. S.; Oddy, T. M.; Archer, M. O.; Eastwood, J. P.; Sanz-Hernández, D.; Sample, J. G.; Cupido, E.; O'Brien, H.; Carr, C. M.

    2014-12-01

    We report on the design and development of a low resource, dual sensor vector magnetometer for space science applications on very small spacecraft. It is based on a hybrid device combining an orthogonal triad of commercial anisotropic magnetoresistive (AMR) sensors with a totem pole H-Bridge drive on a ceramic substrate. The drive enables AMR operation in the more sensitive flipped mode and this is achieved without the need for current spike transmission down a sensor harness. The magnetometer has sensitivity of better than 3 nT in a 0-10 Hz band and a total mass of 104 g. Three instruments have been launched as part of the TRIO-CINEMA space weather mission, inter-calibration against the International Geomagnetic Reference Field model makes it possible to extract physical signals such as field-aligned current deflections of 20-60 nT within an approximately 45 000 nT ambient field.

  13. [Active crop canopy sensor-based nitrogen diagnosis for potato].

    Science.gov (United States)

    Yu, Jing; Li, Fei; Qin, Yong-Lin; Fan, Ming-Shou

    2013-11-01

    In the present study, two potato experiments involving different N rates in 2011 were conducted in Wuchuan County and Linxi County, Inner Mongolia. Normalized difference vegetation index (NDVI) was collected by an active GreenSeeker crop canopy sensor to estimate N status of potato. The results show that the NDVI readings were poorly correlated with N nutrient indicators of potato at vegetative Growth stage due to the influence of soil background. With the advance of growth stages, NDVI values were exponentially related to plant N uptake (R2 = 0.665) before tuber bulking stage and were linearly related to plant N concentration (R2 = 0.699) when plant fully covered soil. In conclusion, GreenSeeker active crop sensor is a promising tool to estimate N status for potato plants. The findings from this study may be useful for developing N recommendation method based on active crop canopy sensor.

  14. External Force Estimation for Teleoperation Based on Proprioceptive Sensors

    Directory of Open Access Journals (Sweden)

    Enrique del Sol

    2014-03-01

    Full Text Available This paper establishes an approach to external force estimation for telerobotic control in radioactive environments by the use of an identified manipulator model and pressure sensors, without employing a force/torque sensor. The advantages of - and need for - force feedback have been well-established in the field of telerobotics, where electrical and back-drivable manipulators have traditionally been used. This research proposes a methodology employing hydraulic robots for telerobotics tasks based on a model identification scheme. Comparative results of a force sensor and the proposed approach using a hydraulic telemanipulator are presented under different conditions. This approach not only presents a cost effective solution but also a methodology for force estimation in radioactive environments, where the dose rates limit the use of electronic devices such as sensing equipment.

  15. Estimating spacecraft attitude based on in-orbit sensor measurements

    DEFF Research Database (Denmark)

    Jakobsen, Britt; Lyn-Knudsen, Kevin; Mølgaard, Mathias

    2014-01-01

    of 2014/15. To better evaluate the performance of the payload, it is desirable to couple the payload data with the satellite's orientation. With AAUSAT3 already in orbit it is possible to collect data directly from space in order to evaluate the performance of the attitude estimation. An extended kalman...... filter (EKF) is used for quaternion-based attitude estimation. A Simulink simulation environment developed for AAUSAT3, containing a "truth model" of the satellite and the orbit environment, is used to test the performance The performance is tested using different sensor noise parameters obtained both...... from a controlled environment on Earth as well as in-orbit. By using sensor noise parameters obtained on Earth as the expected parameters in the attitude estimation, and simulating the environment using the sensor noise parameters from space, it is possible to assess whether the EKF can be designed...

  16. Terahertz Metamaterial Sensor Based on Electromagnetically Induced Transparency Effect

    Institute of Scientific and Technical Information of China (English)

    Shao-Xian Li; Hong-Wei Zhao; Jia-Guang Han

    2015-01-01

    A terahertz metamaterial sensor adopting the metamaterial-based electromagnetically induced transparency (EIT) effect is presented for determining the 1,4-dioxane concentration in its aqueous solution. The metamaterial sensor, which consists of an EIT element unit with a cut-wire metallic resonator and two split-ring metallic resonators fabricated on a 490-µm thick silicon substrate, operates in a transmission geometry. The EIT peak was red-shifted and decreased with the increase of the water volume. A maximum red- shift about 54GHz of the EIT peak was detected between the 1,4-dioxane and water. The presented linear behavior and high sensitivity of the EIT peak depending on the water concentration pave a novel avenue for sensor applications.

  17. Hydrogen Gas Sensors Based on Semiconductor Oxide Nanostructures

    Directory of Open Access Journals (Sweden)

    Yongming Hu

    2012-04-01

    Full Text Available Recently, the hydrogen gas sensing properties of semiconductor oxide (SMO nanostructures have been widely investigated. In this article, we provide a comprehensive review of the research progress in the last five years concerning hydrogen gas sensors based on SMO thin film and one-dimensional (1D nanostructures. The hydrogen sensing mechanism of SMO nanostructures and some critical issues are discussed. Doping, noble metal-decoration, heterojunctions and size reduction have been investigated and proved to be effective methods for improving the sensing performance of SMO thin films and 1D nanostructures. The effect on the hydrogen response of SMO thin films and 1D nanostructures of grain boundary and crystal orientation, as well as the sensor architecture, including electrode size and nanojunctions have also been studied. Finally, we also discuss some challenges for the future applications of SMO nanostructured hydrogen sensors.

  18. Acoustic vibration sensor based on nonadiabatic tapered fibers.

    Science.gov (United States)

    Xu, Ben; Li, Yi; Sun, Miao; Zhang, Zhen-Wei; Dong, Xin-Yong; Zhang, Zai-Xuan; Jin, Shang-Zhong

    2012-11-15

    A simple and low-cost vibration sensor based on single-mode nonadiabatic fiber tapers is proposed and demonstrated. The environmental vibrations can be detected by demodulating the transmission loss of the nonadiabatic fiber taper. Theoretical simulations show that the transmission loss is related to the microbending of the fiber taper induced by vibrations. Unlike interferometric sensors, this vibration sensor does not need any feedback loop to control the quadrature point to obtain a stable performance. In addition, it has no requirement for the coherence of the light source and is insensitive to temperature changes. Experimental results show that this sensing system has a wide frequency response range from a few hertz to tens of kilohertz with the maximal signal to noise ratio up to 73 dB.

  19. An SV-GMR Needle Sensor-Based Estimation of Volume Density of Magnetic Fluid inside Human Body

    Directory of Open Access Journals (Sweden)

    C. P. Gooneratne

    2008-01-01

    Full Text Available A spin-valve giant magneto-resistive (SV-GMR sensor of needle-type configuration is reported to estimate the volume density of magnetic fluid inside human body. The magnetic fluid is usually injected into human body to kill cancerous cell using hyperthermia-based treatment. To control the heat treatment, a good knowledge of temperature is very much essential. The SV-GMR-based needle-type sensor is used to measure the magnetic flux density of the magnetic fluid inside the human body from which the temperature is estimated. The needle-type sensor provides a semi-invasive approach of temperature determination.

  20. Fiber-distributed multi-channel open-path H2S sensor based on tunable diode laser absorption spectroscopy

    Institute of Scientific and Technical Information of China (English)

    Dong Chen; Wenqing Liu; Yujun Zhang; Jianguo Liu; Ruifeng Kan; Min Wang; Xi Fang; Yiben Cui

    2007-01-01

    Tunable diode laser based gas detectors are now being used in a wide variety of applications for safety and environmental interest. A fiber-distributed multi-channel open-path H2S sensor based on tunable diode laser absorption spectroscopy (TDLAS) is developed, the laser used is a telecommunication near infrared distributed feed-back (DFB) tunable diode laser, combining with wavelength modulation specby combining optical fiber technique. An on-board reference cell provides on-line sensor calibration and almost maintenance-free operation. The sensor is suitable for large area field H2S monitoring application.

  1. Photocatalytically Renewable Micro-electrochemical Sensor for Real-Time Monitoring of Cells.

    Science.gov (United States)

    Xu, Jia-Quan; Liu, Yan-Ling; Wang, Qian; Duo, Huan-Huan; Zhang, Xin-Wei; Li, Yu-Tao; Huang, Wei-Hua

    2015-11-23

    Electrode fouling and passivation is a substantial and inevitable limitation in electrochemical biosensing, and it is a great challenge to efficiently remove the contaminant without changing the surface structure and electrochemical performance. Herein, we propose a versatile and efficient strategy based on photocatalytic cleaning to construct renewable electrochemical sensors for cell analysis. This kind of sensor was fabricated by controllable assembly of reduced graphene oxide (RGO) and TiO2 to form a sandwiching RGO@TiO2 structure, followed by deposition of Au nanoparticles (NPs) onto the RGO shell. The Au NPs-RGO composite shell provides high electrochemical performance. Meanwhile, the encapsulated TiO2 ensures an excellent photocatalytic cleaning property. Application of this renewable microsensor for detection of nitric oxide (NO) release from cells demonstrates the great potential of this strategy in electrode regeneration and biosensing.

  2. Hair-based sensors for micro-autonomous systems

    Science.gov (United States)

    Sadeghi, Mahdi M.; Peterson, Rebecca L.; Najafi, Khalil

    2012-06-01

    We seek to harness microelectromechanical systems (MEMS) technologies to build biomimetic devices for low-power, high-performance, robust sensors and actuators on micro-autonomous robot platforms. Hair is used abundantly in nature for a variety of functions including balance and inertial sensing, flow sensing and aerodynamic (air foil) control, tactile and touch sensing, insulation and temperature control, particle filtering, and gas/chemical sensing. Biological hairs, which are typically characterized by large surface/volume ratios and mechanical amplification of movement, can be distributed in large numbers over large areas providing unprecedented sensitivity, redundancy, and stability (robustness). Local neural transduction allows for space- and power-efficient signal processing. Moreover by varying the hair structure and transduction mechanism, the basic hair form can be used for a wide diversity of functions. In this paper, by exploiting a novel wafer-level, bubble-free liquid encapsulation technology, we make arrays of micro-hydraulic cells capable of electrostatic actuation and hydraulic amplification, which enables high force/high deflection actuation and extremely sensitive detection (sensing) at low power. By attachment of cilia (hair) to the micro-hydraulic cell, air flow sensors with excellent sensitivity ( 10 m/s) have been built. A second-generation design has significantly reduced the sensor response time while maintaining sensitivity of about 2 cm/s and dynamic range of more than 15 m/s. These sensors can be used for dynamic flight control of flying robots or for situational awareness in surveillance applications. The core biomimetic technologies developed are applicable to a broad range of sensors and actuators.

  3. Graphene-based composite sensors for energy applications

    Science.gov (United States)

    Chadhari, S.; Graves, A. R.; Cain, M. V.; Stinespring, C. D.

    2016-05-01

    The long range objectives of this research are to develop and demonstrate the use of graphene-nanoparticle composites as a high sensitivity, rapid response electronic nose for gas sensing in energy applications. Graphene based device structures suitable for temperatures as high as 1000 °C are targeted. The scope of work includes: a) development of procedures for controllable nucleation and growth of nanoparticles on graphene surfaces, b) fabrication graphene-nanoparticle composite sensors, c) measurement of electrical properties of graphene-nanoparticle composites, and d) determination of sensor characteristics (selectivity and sensitivity). The graphene films are synthesized on 6H-SiC (0001) surfaces using a halogen based plasma etching followed by rapid thermal annealing in atmospheric pressure Ar or under ultrahigh vacuum conditions. Lithography free methods are then used to produce simple sensor structures consisting of interdigitated fingers. This is followed by the nucleation of either Ag, Au, Pt, or Ir nanoparticles on the graphene surfaces using solution based techniques. Atomic force microscopy is used to characterize the particle size distribution of the nucleated nanoparticles. Electrical properties of the graphene and graphenenanoparticle composites are characterized using two point current-voltage measurements. Gas sensor response as a function of temperature is characterized for H2 in Ar gas mixtures.

  4. Chain-based communication in cylindrical underwater wireless sensor networks.

    Science.gov (United States)

    Javaid, Nadeem; Jafri, Mohsin Raza; Khan, Zahoor Ali; Alrajeh, Nabil; Imran, Muhammad; Vasilakos, Athanasios

    2015-01-01

    Appropriate network design is very significant for Underwater Wireless Sensor Networks (UWSNs). Application-oriented UWSNs are planned to achieve certain objectives. Therefore, there is always a demand for efficient data routing schemes, which can fulfill certain requirements of application-oriented UWSNs. These networks can be of any shape, i.e., rectangular, cylindrical or square. In this paper, we propose chain-based routing schemes for application-oriented cylindrical networks and also formulate mathematical models to find a global optimum path for data transmission. In the first scheme, we devise four interconnected chains of sensor nodes to perform data communication. In the second scheme, we propose routing scheme in which two chains of sensor nodes are interconnected, whereas in third scheme single-chain based routing is done in cylindrical networks. After finding local optimum paths in separate chains, we find global optimum paths through their interconnection. Moreover, we develop a computational model for the analysis of end-to-end delay. We compare the performance of the above three proposed schemes with that of Power Efficient Gathering System in Sensor Information Systems (PEGASIS) and Congestion adjusted PEGASIS (C-PEGASIS). Simulation results show that our proposed 4-chain based scheme performs better than the other selected schemes in terms of network lifetime, end-to-end delay, path loss, transmission loss, and packet sending rate.

  5. Magnetic field sensor using a polymer-based vibrator

    Science.gov (United States)

    Wu, Jiang; Hasebe, Kazuhiko; Mizuno, Yosuke; Tabaru, Marie; Nakamura, Kentaro

    2016-09-01

    In this technical note, a polymer-based magnetic sensor with a high resolution was devised for sensing the high magnetic field. It consisted of a bimorph (vibrator) made of poly (phenylene sulfide) (PPS) and a phosphor-bronze foil glued on the free end of the bimorph. According to Faraday’s law of induction, when a magnetic field in the direction perpendicular to the bimorph was applied, the foil cut the magnetic flux, and generated an alternating voltage across the leads at the natural frequency of the bimorph. Because PPS has low mechanical loss, low elastic modulus, and low density, high vibration velocity can be achieved if it is employed as the elastomer of the bimorph. The devised sensor was tested in the magnetic field range of 0.1-570 mT and exhibited a minimum detectable magnetic field of 0.1 mT. At a zero-to-peak driving voltage of 60 V, the sensitivity of the PPS-based magnetic sensor reached 10.5 V T-1, which was 1.36 times the value of the aluminum-based magnetic sensor with the same principle and dimensions.

  6. Chain-Based Communication in Cylindrical Underwater Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Nadeem Javaid

    2015-02-01

    Full Text Available Appropriate network design is very significant for Underwater Wireless Sensor Networks (UWSNs. Application-oriented UWSNs are planned to achieve certain objectives. Therefore, there is always a demand for efficient data routing schemes, which can fulfill certain requirements of application-oriented UWSNs. These networks can be of any shape, i.e., rectangular, cylindrical or square. In this paper, we propose chain-based routing schemes for application-oriented cylindrical networks and also formulate mathematical models to find a global optimum path for data transmission. In the first scheme, we devise four interconnected chains of sensor nodes to perform data communication. In the second scheme, we propose routing scheme in which two chains of sensor nodes are interconnected, whereas in third scheme single-chain based routing is done in cylindrical networks. After finding local optimum paths in separate chains, we find global optimum paths through their interconnection. Moreover, we develop a computational model for the analysis of end-to-end delay. We compare the performance of the above three proposed schemes with that of Power Efficient Gathering System in Sensor Information Systems (PEGASIS and Congestion adjusted PEGASIS (C-PEGASIS. Simulation results show that our proposed 4-chain based scheme performs better than the other selected schemes in terms of network lifetime, end-to-end delay, path loss, transmission loss, and packet sending rate.

  7. Significant Storage on Sensor Storage Space, Energy Consumption and Better Security Based on Routing in Hybrid Sensor Networks

    Directory of Open Access Journals (Sweden)

    K.Nageswara rao

    2011-12-01

    Full Text Available WSNs are characterized by limited resources in term s of communication, computation and energy supply. A critical constraint on sensors networks is that s ensor nodes employ batteries. A second constraint i s that sensors will be deployed unattended and in large nu mbers, so that it will be difficult to change or re charge batteries in the sensors .The Energy Consumption in wireless sensor networks varies greatly based on t he protocols the sensors use and computations used to generate keys for communication among neighbor nodes. Previous research on sensor network security mainly considers homogeneous sensor networks, where all sensor nodes have the same capabilities. Research has shown that homogeneous ad hoc networks have poor performance and scalability. The many-to- one traffic pattern dominates in sensor networks, a nd hence a sensor may only communicate with a small po rtion of its neighbors. Key Management is a fundamental security operation. Most existing key m anagement schemes try to establish shared keys for all pairs of neighbor sensors, no matter whether these nodes communicate with each other or not, and this causes large overhead and more energy consumption a nd more storage requirement. In this paper, we adopt a Hybrid Sensor Network (HSN model for bette r performance and security. We propose a novel routing-driven key establishment scheme, which only establishes shared keys for neighbor sensors that communicate with each other. We utilize Elliptic Cu rve Cryptography in the design of an efficient key Establishment scheme for sensor nodes. The performa nce evaluation and security analysis show that our key Establishment scheme can provide better securit y with significant reductions on communication overhead, storage space and energy consumption than other key Establishment schemes.

  8. CO Responses of Sensors Based on Cerium Oxide Thick Films Prepared from Clustered Spherical Nanoparticles

    OpenAIRE

    Woosuck Shin; Takafumi Akamatsu; Toshio Itoh; Ichiro Matsubara; Noriya Izu

    2013-01-01

    Various types of CO sensors based on cerium oxide (ceria) have been reported recently. It has also been reported that the response speed of CO sensors fabricated from porous ceria thick films comprising nanoparticles is extremely high. However, the response value of such sensors is not suitably high. In this study, we investigated methods of improving the response values of CO sensors based on ceria and prepared gas sensors from core-shell ceria polymer hybrid nanoparticles. These hybrid nano...

  9. Graphene-Based Chemical Vapor Sensors for Electronic Nose Applications

    Science.gov (United States)

    Nallon, Eric C.

    chemiresistor device and used as a chemical sensor, where its resistance is temporarily modified while exposed to chemical compounds. The inherent, broad selective nature of graphene is demonstrated by testing a sensor against a diverse set of volatile organic compounds and also against a set of chemically similar compounds. The sensor exhibits excellent selectivity and is capable of achieving high classification accuracies. The kinetics of the sensor's response are further investigated revealing a relationship between the transient behavior of the response curve and physiochemical properties of the compounds, such as the molar mass and vapor pressure. This kinetic information is also shown to provide important information for further pattern recognition and classification, which is demonstrated by increased classification accuracy of very similar compounds. Covalent modification of the graphene surface is demonstrated by means of plasma treatment and free radical exchange, and sensing performance compared to an unmodified graphene sensor. Finally, the first example of a graphene-based, cross-reactive chemical sensor array is demonstrated by applying various polymers as coatings over an array of graphene sensors. The sensor array is tested against a variety of compounds, including the complex odor of Scotch whiskies, where it is capable of perfect classification of 10 Scotch whiskey variations.

  10. A highly accurate wireless digital sun sensor based on profile detecting and detector multiplexing technologies

    Science.gov (United States)

    Wei, Minsong; Xing, Fei; You, Zheng

    2017-01-01

    The advancing growth of micro- and nano-satellites requires miniaturized sun sensors which could be conveniently applied in the attitude determination subsystem. In this work, a profile detecting technology based high accurate wireless digital sun sensor was proposed, which could transform a two-dimensional image into two-linear profile output so that it can realize a high update rate under a very low power consumption. A multiple spots recovery approach with an asymmetric mask pattern design principle was introduced to fit the multiplexing image detector method for accuracy improvement of the sun sensor within a large Field of View (FOV). A FOV determination principle based on the concept of FOV region was also proposed to facilitate both sub-FOV analysis and the whole FOV determination. A RF MCU, together with solar cells, was utilized to achieve the wireless and self-powered functionality. The prototype of the sun sensor is approximately 10 times lower in size and weight compared with the conventional digital sun sensor (DSS). Test results indicated that the accuracy of the prototype was 0.01° within a cone FOV of 100°. Such an autonomous DSS could be equipped flexibly on a micro- or nano-satellite, especially for highly accurate remote sensing applications.

  11. Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem.

    Science.gov (United States)

    Weltin, Andreas; Slotwinski, Kinga; Kieninger, Jochen; Moser, Isabella; Jobst, Gerhard; Wego, Marcus; Ehret, Ralf; Urban, Gerald A

    2014-01-07

    We present a novel, multiparametric microphysiometry system for the dynamic online monitoring of human cancer cell metabolism. The optically transparent, modular, hybrid microsystem is based on a glass chip and combines a cell cultivation chamber, microfluidics and metabolic monitoring with fully integrated chemo- and biosensors. pH and oxygen are measured in the cell culture area, and biosensors for lactate and glucose are connected downstream by microfluidics. The wafer-level fabrication features thin-film platinum and iridium oxide microelectrodes on a glass chip, microfluidics in an epoxy resist, a hybrid assembly and an on-chip reference electrode. The reliable analytical performance of the sensors in cell culture medium was demonstrated. The pH sensors exhibit a long-term stable, linear response. The oxygen sensors show a linear behaviour, which is also observed for low oxygen concentrations. Glucose and lactate measurements show a linear, long-term stable, selective and reversible behaviour in the desired range. T98G human brain cancer cells were cultivated and cell culture metabolism was measured on-chip. Stop/flow cycles were applied and extracellular acidification, respiration, glucose consumption and lactate production were quantified. Long-term metabolic rates were determined and all parameters could be measured in the outlet channel. A placement downstream of the cell cultivation area for biosensors was realised. A highly effective medium exchange and undiluted sampling from the cell culture chamber with low flow rates (2 μl min(-1)) and low volumes (15 μl per cycle) were achieved. The drug screening application was demonstrated by detecting alteration and recovery effects of cellular metabolism induced by the addition of substances to the medium.

  12. ‘Baseline-offset’ scheme for a methane remote sensor based on wavelength modulation spectroscopy

    Science.gov (United States)

    Ding, Wuwen; Sun, Liqun; Yi, Luying; Zhang, Enyao

    2016-08-01

    A new scheme for methane remote sensing is presented. Unlike a standard published remote sensor based on wavelength modulation spectroscopy (WMS), a reference cell is inserted into the measuring optical path. This scheme inherits the merits of WMS and can achieve high signal-to-noise ratio especially in a low concentration environment. Experimental results show that the presented remote sensor can detect ambient methane with a detection limit of 5 ppm m (parts per million · meter) at a distance of 10 m and 16 ppm m for 20 m. A methane leak test shows the sensor can detect a methane leak of 15 ml min-1 within a range up to 37 m.

  13. Differential microfluidic sensor on printed circuit board for biological cells analysis.

    Science.gov (United States)

    Shi, Dongyuan; Guo, Jinhong; Chen, Liang; Xia, Chuncheng; Yu, Zhefeng; Ai, Ye; Li, Chang Ming; Kang, Yuejun; Wang, Zhiming

    2015-08-01

    Coulter principal based resistive pulse sensor has been demonstrated as an important platform in biological cell detection and enumeration since several decades ago. Recently, the miniaturized micro-Coulter counter has attracted much attention due to its advantages in point of care diagnostics for on chip detection and enumeration of rare cells, such as circulating tumor cells. In this paper, we present a microfluidic cytometer with differential amplifier based on Coulter principle on a SU-8 coated printed circuit board substrate. The electrical current changes induced by the blockage of the microparticles in the sensing aperture are calibrated by polystyrene particles of standard size. Finally, HeLa cells are used to evaluate the performance of the proposed device for enumeration of biological samples. The proposed cytometer is built upon the cheap and widely available printed circuit board substrate and shows its great potential as personalized healthcare monitor.

  14. Photonic crystal fiber based chloride chemical sensors for corrosion monitoring

    Science.gov (United States)

    Wei, Heming; Tao, Chuanyi; Krishnaswamy, Sridhar

    2016-04-01

    Corrosion of steel is one of the most important durability issues in reinforced concrete (RC) structures because aggressive ions such as chloride ions permeate concrete and corrode steel, consequently accelerating the destruction of structures, especially in marine environments. There are many practical methods for corrosion monitoring in RC structures, mostly focusing on electrochemical-based sensors for monitoring the chloride ion which is thought as one of the most important factors resulting in steel corrosion. In this work, we report a fiber-optic chloride chemical sensor based on long period gratings inscribed in a photonic crystal fiber (PCF) with a chloride sensitive thin film. Numerical simulation is performed to determine the characteristics and resonance spectral response versus the refractive indices of the analyte solution flowing through into the holes in the PCF. The effective refractive index of the cladding mode of the LPGs changes with variations of the analyte solution concentration, resulting in a shift of the resonance wavelength, hence providing the sensor signal. This fiber-optic chemical sensor has a fast response, is easy to prepare and is not susceptible to electromagnetic environment, and can therefore be of use for structural health monitoring of RC structures subjected to such aggressive environments.

  15. Corrosion Sensor Development for Condition-Based Maintenance of Aircraft

    Directory of Open Access Journals (Sweden)

    Gino Rinaldi

    2012-01-01

    Full Text Available Aircraft routinely operate in atmospheric environments that, over time, will impact their structural integrity. Material protection and selection schemes notwithstanding, recurrent exposure to chlorides, pollution, temperature gradients, and moisture provide the necessary electrochemical conditions for the development and profusion of corrosion in aircraft structures. For aircraft operators, this becomes an important safety matter as corrosion found in a given aircraft must be assumed to be present in all of that type of aircraft. This safety protocol and its associated unscheduled maintenance requirement drive up the operational costs of the fleet and limit the availability of the aircraft. Hence, there is an opportunity at present for developing novel sensing technologies and schemes to aid in shifting time-based maintenance schedules towards condition-based maintenance procedures. In this work, part of the ongoing development of a multiparameter integrated corrosion sensor is presented. It consists of carbon nanotube/polyaniline polymer sensors and commercial-off-the-shelf sensors. It is being developed primarily for monitoring environmental and material factors for the purpose of providing a means to more accurately assess the structural integrity of aerospace aluminium alloys through fusion of multiparameter sensor data. Preliminary experimental test results are presented for chloride ion concentration, hydrogen gas evolution, humidity variations, and material degradation.

  16. Determination of Lead with a Copper-Based Electrochemical Sensor.

    Science.gov (United States)

    Kang, Wenjing; Pei, Xing; Rusinek, Cory A; Bange, Adam; Haynes, Erin N; Heineman, William R; Papautsky, Ian

    2017-03-21

    This work demonstrates determination of lead (Pb) in surface water samples using a low-cost copper (Cu)-based electrochemical sensor. Heavy metals require careful monitoring due to their toxicity, yet current methods are too complex or bulky for point-of-care (POC) use. Electrochemistry offers a convenient alternative for metal determination, but the traditional electrodes, such as carbon or gold/platinum, are costly and difficult to microfabricate. Our copper-based sensor features a low-cost electrode material-copper-that offers simple fabrication and competitive performance in electrochemical detection. For anodic stripping voltammetry (ASV) of Pb, our sensor shows 21 nM (4.4 ppb) limit of detection, resistance to interfering metals such as cadmium (Cd) and zinc (Zn), and stable response in natural water samples with minimum sample pretreatment. These results suggest this electrochemical sensor is suitable for environmental and potentially biological applications, where accurate and rapid, yet inexpensive, on-site monitoring is necessary.

  17. Framework of sensor-based monitoring for pervasive patient care.

    Science.gov (United States)

    Triantafyllidis, Andreas K; Koutkias, Vassilis G; Chouvarda, Ioanna; Adami, Ilia; Kouroubali, Angelina; Maglaveras, Nicos

    2016-09-01

    Sensor-based health systems can often become difficult to use, extend and sustain. The authors propose a framework for designing sensor-based health monitoring systems aiming to provide extensible and usable monitoring services in the scope of pervasive patient care. The authors' approach relies on a distributed system for monitoring the patient health status anytime-anywhere and detecting potential health complications, for which healthcare professionals and patients are notified accordingly. Portable or wearable sensing devices measure the patient's physiological parameters, a smart mobile device collects and analyses the sensor data, a Medical Center system receives notifications on the detected health condition, and a Health Professional Platform is used by formal caregivers in order to review the patient condition and configure monitoring schemas. A Service-oriented architecture is utilised to provide extensible functional components and interoperable interactions among the diversified system components. The framework was applied within the REMOTE ambient-assisted living project in which a prototype system was developed, utilising Bluetooth to communicate with the sensors and Web services for data exchange. A scenario of using the REMOTE system and preliminary usability results show the applicability, usefulness and virtue of our approach.

  18. Smart sensor-based geospatial architecture for dike monitoring

    Science.gov (United States)

    Herle, S.; Becker, R.; Blankenbach, J.

    2016-04-01

    Artificial hydraulic structures like dams or dikes used for water level regulations or flood prevention are continuously under the influence of the weather and variable river regimes. Thus, ongoing monitoring and simulation is crucial in order to determine the inner condition. Potentially life-threatening situations, in extreme case a failure, must be counteracted by all available means. Nowadays flood warning systems rely exclusively on water level forecast without considering the state of the structure itself. Area-covering continuous knowledge of the inner state including time dependent changes increases the capability of recognizing and locating vulnerable spots for early treatment. In case of a predicted breach, advance warning time for alerting affected citizens can be extended. Our approach is composed of smart sensors integrated in a service-oriented geospatial architecture to monitor and simulate artificial hydraulic structures continuously. The sensors observe the inner state of the construction like the soil moisture or the stress and deformation over time but also various external influences like water levels or wind speed. They are interconnected in distributed network architecture by a so-called sensor bus system based on lightweight protocols like Message Queue Telemetry Transport for Sensor Networks (MQTT-SN). These sensor data streams are transferred into an OGC Sensor Web Enablement (SWE) data structure providing high-level geo web services to end users. Bundled with 3rd party geo web services (WMS etc.) powerful processing and simulation tools can be invoked using the Web Processing Service (WPS) standard. Results will be visualized in a geoportal allowing user access to all information.

  19. Commercialization Issues For Catheter-Based Electrochemical Sensors

    Science.gov (United States)

    Nikolchev, Julian; Gaisford, Scott

    1989-08-01

    The need for continuous monitoring of key clinical parameters in hospitals is well recognized. Figure 1 shows typical time constants for blood gases, ions and enzymes in response to acute ventilatory changes and interventions. Although it can be seen that relatively low rates of data collection are necessary for many medical measurements, it is also clear that intermittent measurement of P02, PCO2 and pH are not sufficient to provide safe and effective management of the patient. Very frequent or continuous monitoring is often essential. This figure also shows why the emphasis of a large number of research efforts in this country and in Europe and Japan have as their goal the development of continuous blood gas sensors, i.e., sensors that continuously monitor blood pH, partial pressure of oxygen and partial pressure of carbon dioxide. These are three (3) of the most frequent parameters measured in hospitals and the ones having the shortest time constant. Considering that in the United States alone close to 25 million blood gas samples per year are taken from patients, the potential market for continuous monitoring sensors is enormous. The emergence of microelectronics and microfabrication technologies over the past 30 years are now pointing to a possible resolution of the well recognized need for real time monitoring of critically ill patients through catheter-based sensors. Although physicians will always prefer non-invasive monitoring techniques, there are a number of parameters that presently can only be monitored by invasive method. The emerging ability to miniaturize chemical sensors using silicon microfabrication or fiber-optic techniques offer an excellent opportunity to solve this need. In fact, the development of in vivo biomedical sensors with satisfactory performance characteristics has long been considered the ultimate application of these emerging technologies.

  20. Monitoring and Control Interface Based on Virtual Sensors

    Directory of Open Access Journals (Sweden)

    Ricardo F. Escobar

    2014-10-01

    Full Text Available In this article, a toolbox based on a monitoring and control interface (MCI is presented and applied in a heat exchanger. The MCI was programed in order to realize sensor fault detection and isolation and fault tolerance using virtual sensors. The virtual sensors were designed from model-based high-gain observers. To develop the control task, different kinds of control laws were included in the monitoring and control interface. These control laws are PID, MPC and a non-linear model-based control law. The MCI helps to maintain the heat exchanger under operation, even if a temperature outlet sensor fault occurs; in the case of outlet temperature sensor failure, the MCI will display an alarm. The monitoring and control interface is used as a practical tool to support electronic engineering students with heat transfer and control concepts to be applied in a double-pipe heat exchanger pilot plant. The method aims to teach the students through the observation and manipulation of the main variables of the process and by the interaction with the monitoring and control interface (MCI developed in LabVIEW©. The MCI provides the electronic engineering students with the knowledge of heat exchanger behavior, since the interface is provided with a thermodynamic model that approximates the temperatures and the physical properties of the fluid (density and heat capacity. An advantage of the interface is the easy manipulation of the actuator for an automatic or manual operation. Another advantage of the monitoring and control interface is that all algorithms can be manipulated and modified by the users.

  1. Multiple sensors-based kernel machine learning in smart environment

    Science.gov (United States)

    Li, Jun-Bao; Pan, Jeng-Shyang

    2017-01-01

    Sensor-based monitoring systems use multiple sensors to identify high-level information based on the events that take place in a monitored environment. Identification and health care are important tasks in the smart environment. This paper presents a framework for multisensory multimedia data analysis using a kernel optimization-based principal analysis for identification and health care in a smart environment. Images of faces, palmprints, and fingerprints are used to identify a person, and a wrist pulse signal is used to analyze the person's health condition. The recognition performance evaluations are implemented on the complex dataset of face, palmprint, fingerprint, and wrist pulse signals. The experimental results show that the proposed algorithms perform well for identification and heath analysis.

  2. Certificate Based Security Services in Adhoc Sensor Network

    Directory of Open Access Journals (Sweden)

    Shahin Fatima

    2014-10-01

    Full Text Available The paper entitled “CERTIFICATE BASED SECURITY SERVICES IN ADHOC SENSOR NETWORK” proposed an approach in which the aim is to find the method for authentication which is more energy efficient and reduces the transmission time of the network. MANETs are of dynamic topology and have no predefined infrastructure. Due to its dynamic topology this network is prone to various kinds of vulnerable attacks. Sensor networks are battery operated and is a major concern. Methods on ID based Authentication consumes more network bandwidth and increases the computation and transmission time of the network. So for better operation, authentication must be the major factor of concern. In this paper a method for authentication in adhoc sensor network is proposed which is based on certificate based security services. Here we will make use of X.509 certificate format. In this some modification is made to the certificate format such that the transmission time and energy consumption of the network is reduced. Our proposed model will provide authentication among nodes and security in MANET. The proposed work is implemented in MATLAB and the result will show the effectiveness of proposed certificate in MANET. The objective of certificate based authentication is to ensure that messages can be read by authorized person only. It also overcomes the non repudiation attacks thereby minimizing the computation and shows how energy varies by making changes in certificate of node.

  3. Using Custom Fiber Bragg Grating-Based Sensors to Monitor Artificial Landslides.

    Science.gov (United States)

    Zhang, Qinghua; Wang, Yuan; Sun, Yangyang; Gao, Lei; Zhang, Zhenglin; Zhang, Wenyuan; Zhao, Pengchong; Yue, Yin

    2016-09-02

    Four custom fiber Bragg grating (FBG)-based sensors are developed to monitor an artificial landslide located in Nanjing, China. The sensors are composed of a rod and two FBGs. Based on the strength of the rods, two sensors are referred to as "hard sensors" (Sensor 1 and Sensor 2), the other two are referred to as "soft sensors" (Sensor 3 and Sensor 4). The two FBGs are fixed on each sensor rod at distances of 50 cm and 100 cm from the top of the rod (an upper FBG and a lower FBG). In the experiment presented in this paper, the sensors are installed on a slope on which an artificial landslide is generated through both machine-based and manual excavation. The fiber sensing system consists of the four custom FBG-based sensors, optical fiber, a static fiber grating demodulation instrument (SM125), and a PC with the necessary software. Experimental data was collected in the presence of an artificial landslide, and the results show that the lower FBGs are more sensitive than the upper FBGs for all four of the custom sensors. It was also found that Sensor 2 and Sensor 4 are more capable of monitoring small-scale landslides than Sensor 1 and Sensor 3, and this is mainly due to their placement location with respect to the landslide. The stronger rods used in the hard sensors make them more adaptable to the harsh environments of large landslides. Thus, hard sensors should be fixed near the landslide, while soft sensors should be placed farther away from the landslide. In addition, a clear tendency of strain variation can be detected by the soft sensors, which can be used to predict landslides and raise a hazard alarm.

  4. Sequestering ability to Cu(2+) of a new bodipy-based dye and its behavior as in vitro fluorescent sensor.

    Science.gov (United States)

    Papalia, Teresa; Barattucci, Anna; Barreca, Davide; Bellocco, Ersilia; Bonaccorsi, Paola; Minuti, Lucio; Nicolò, Marco Sebastiano; Temperini, Andrea; Foti, Claudia

    2017-02-01

    A Bodipy (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) derivative has been conceived and synthesized starting from l-aspartic acid, as a selective turn-off sensor of Cu(2+) ions. Its acid-base properties were determined to study the formation of metal/sensor complex species by titration of solutions each containing a different metal ion, such as Cu(2+), Ca(2+), Zn(2+), Pb(2+) and Hg(2+) and different metal/sensor ratios. The speciation models allowed us to simulate the distribution of the metal/sensor complex species at the normal concentrations of the corresponding metals present in biological fluids. The distribution diagrams, obtained by varying the concentration of sensor 1, clearly indicate that sensor 1 responds selectively to Cu(2+) at micromolar concentrations, even in the presence of other more abundant metal cations Ca(2+). Finally, we analyzed the cellular uptake of sensor 1 on human erythrocytes and its ability to chelate Cu(2+) in the cellular environment. Results indicate that it crosses the plasmatic membrane and colors the cells of a bright fluorescent red. Exposing the fluorescent cells to Cu(2+) results in a complete cellular photobleaching of the red fluorescence, indicating that sensor 1 is able to detect metal changes in the cytosolic environment.

  5. FRET-based genetically-encoded sensors for quantitative monitoring of metabolites.

    Science.gov (United States)

    Mohsin, Mohd; Ahmad, Altaf; Iqbal, Muhammad

    2015-10-01

    Neighboring cells in the same tissue can exist in different states of dynamic activities. After genomics, proteomics and metabolomics, fluxomics is now equally important for generating accurate quantitative information on the cellular and sub-cellular dynamics of ions and metabolite, which is critical for functional understanding of organisms. Various spectrometry techniques are used for monitoring ions and metabolites, although their temporal and spatial resolutions are limited. Discovery of the fluorescent proteins and their variants has revolutionized cell biology. Therefore, novel tools and methods targeting sub-cellular compartments need to be deployed in specific cells and targeted to sub-cellular compartments in order to quantify the target-molecule dynamics directly. We require tools that can measure cellular activities and protein dynamics with sub-cellular resolution. Biosensors based on fluorescence resonance energy transfer (FRET) are genetically encoded and hence can specifically target sub-cellular organelles by fusion to proteins or targetted sequences. Since last decade, FRET-based genetically encoded sensors for molecules involved in energy production, reactive oxygen species and secondary messengers have helped to unravel key aspects of cellular physiology. This review, describing the design and principles of sensors, presents a database of sensors for different analytes/processes, and illustrate examples of application in quantitative live cell imaging.

  6. FPGA-Based Embedded Motion Estimation Sensor

    Directory of Open Access Journals (Sweden)

    Zhaoyi Wei

    2008-01-01

    Full Text Available Accurate real-time motion estimation is very critical to many computer vision tasks. However, because of its computational power and processing speed requirements, it is rarely used for real-time applications, especially for micro unmanned vehicles. In our previous work, a FPGA system was built to process optical flow vectors of 64 frames of 640×480 image per second. Compared to software-based algorithms, this system achieved much higher frame rate but marginal accuracy. In this paper, a more accurate optical flow algorithm is proposed. Temporal smoothing is incorporated in the hardware structure which significantly improves the algorithm accuracy. To accommodate temporal smoothing, the hardware structure is composed of two parts: the derivative (DER module produces intermediate results and the optical flow computation (OFC module calculates the final optical flow vectors. Software running on a built-in processor on the FPGA chip is used in the design to direct the data flow and manage hardware components. This new design has been implemented on a compact, low power, high performance hardware platform for micro UV applications. It is able to process 15 frames of 640×480 image per second and with much improved accuracy. Higher frame rate can be achieved with further optimization and additional memory space.

  7. Software sensors as a tool for optimization of animal-cell cultures.

    OpenAIRE

    Dorresteijn, P.C.

    1997-01-01

    In this thesis software sensors are introduced that predict the biomass activity and the concentrations of glucose, glutamine, lactic acid, and ammonium on line, The software sensors for biomass activity, glucose and lactic acid can be applied for any type of animal cell that is grown in a bioreactor system. The glutamine and ammonium software sensors are determined experimentally by correlating them to the acid-production rate. Therefore, they can only be used for Vero cells.In the developme...

  8. Robot Positioning and Navigation Based on Hybrid Wireless Sensor Network

    Institute of Scientific and Technical Information of China (English)

    Shun-cai YAO; Jin-dong TAN; Hong-xia PAN

    2010-01-01

    Traditional sensor network and robot navigation are based an the map of detecting the fields available in advance.The optimal algorithms are developed to solve the energy saving,the shortest path problems,etc.However,in the practical encironment,there are many fields,whose map is difficult to get,and needs to be detected.In this paper a kind of ad-hoc navigation algorithm is explored,which is based on the hybrid sensor network without the prior map in advance.The navigation system is composed of static nodes and dynamic nodes.The static nodes monitor the occurrances of the events and broadcast them.In the system,a kind of algorithm is to locate the robot,which is based on cluster broadcasting.The dynamic nodes detect the adversary or dangerous fields and broadcast warning messages.The robot gets the message and follows ad-hoc routine to arrive where the events occur.In the whole process,energy saving has been taken into account.The algorithms,which are based on the hybrid sensor network,are given in this paper.The simulation and practical results are also available.

  9. ENERGY OPTIMIZATION IN CLUSTER BASED WIRELESS SENSOR NETWORKS

    Directory of Open Access Journals (Sweden)

    T. SHANKAR

    2014-04-01

    Full Text Available Wireless sensor networks (WSN are made up of sensor nodes which are usually battery-operated devices, and hence energy saving of sensor nodes is a major design issue. To prolong the networks lifetime, minimization of energy consumption should be implemented at all layers of the network protocol stack starting from the physical to the application layer including cross-layer optimization. Optimizing energy consumption is the main concern for designing and planning the operation of the WSN. Clustering technique is one of the methods utilized to extend lifetime of the network by applying data aggregation and balancing energy consumption among sensor nodes of the network. This paper proposed new version of Low Energy Adaptive Clustering Hierarchy (LEACH, protocols called Advanced Optimized Low Energy Adaptive Clustering Hierarchy (AOLEACH, Optimal Deterministic Low Energy Adaptive Clustering Hierarchy (ODLEACH, and Varying Probability Distance Low Energy Adaptive Clustering Hierarchy (VPDL combination with Shuffled Frog Leap Algorithm (SFLA that enables selecting best optimal adaptive cluster heads using improved threshold energy distribution compared to LEACH protocol and rotating cluster head position for uniform energy dissipation based on energy levels. The proposed algorithm optimizing the life time of the network by increasing the first node death (FND time and number of alive nodes, thereby increasing the life time of the network.

  10. Energy Aware Cluster Based Routing Scheme For Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    Roy Sohini

    2015-09-01

    Full Text Available Wireless Sensor Network (WSN has emerged as an important supplement to the modern wireless communication systems due to its wide range of applications. The recent researches are facing the various challenges of the sensor network more gracefully. However, energy efficiency has still remained a matter of concern for the researches. Meeting the countless security needs, timely data delivery and taking a quick action, efficient route selection and multi-path routing etc. can only be achieved at the cost of energy. Hierarchical routing is more useful in this regard. The proposed algorithm Energy Aware Cluster Based Routing Scheme (EACBRS aims at conserving energy with the help of hierarchical routing by calculating the optimum number of cluster heads for the network, selecting energy-efficient route to the sink and by offering congestion control. Simulation results prove that EACBRS performs better than existing hierarchical routing algorithms like Distributed Energy-Efficient Clustering (DEEC algorithm for heterogeneous wireless sensor networks and Energy Efficient Heterogeneous Clustered scheme for Wireless Sensor Network (EEHC.

  11. A Microring Temperature Sensor Based on the Surface Plasmon Wave

    Directory of Open Access Journals (Sweden)

    Wenchao Li

    2015-01-01

    Full Text Available A structure of microring sensor suitable for temperature measurement based on the surface plasmon wave is put forward in this paper. The sensor uses surface plasmon multilayer waveguiding structure in the vertical direction and U-shaped microring structure in the horizontal direction and utilizes SOI as the thermal material. The transfer function derivation of the structure of surface plasmon microring sensor is according to the transfer matrix method. While the change of refractive index of Si is caused by the change of ambient temperature, the effective refractive index of the multilayer waveguiding structure is changed, resulting in the drifting of the sensor output spectrum. This paper focuses on the transmission characteristics of multilayer waveguide structure and the impact on the output spectrum caused by refractive index changes in temperature parts. According to the calculation and simulation, the transmission performance of the structure is stable and the sensitivity is good. The resonance wavelength shift can reach 0.007 μm when the temperature is increased by 100 k and FSR can reach about 60 nm. This structure achieves a high sensitivity in the temperature sense taking into account a wide range of filter frequency selections, providing a theoretical basis for the preparation of microoptics.

  12. Nanoporous Pirani sensor based on anodic aluminum oxide

    Science.gov (United States)

    Jeon, Gwang-Jae; Kim, Woo Young; Shim, Hyun Bin; Lee, Hee Chul

    2016-09-01

    A nanoporous Pirani sensor based on anodic aluminum oxide (AAO) is proposed, and the quantitative relationship between the performance of the sensor and the porosity of the AAO membrane is characterized with a theoretical model. The proposed Pirani sensor is composed of a metallic resistor on a suspended nanoporous membrane, which simultaneously serves as the sensing area and the supporting structure. The AAO membrane has numerous vertically-tufted nanopores, resulting in a lower measurable pressure limit due to both the increased effective sensing area and the decreased effective thermal loss through the supporting structure. Additionally, the suspended AAO membrane structure, with its outer periphery anchored to the substrate, known as a closed-type design, is demonstrated using nanopores of AAO as an etch hole without a bulk micromachining process used on the substrate. In a CMOS-compatible process, a 200 μm × 200 μm nanoporous Pirani sensor with porosity of 25% was capable of measuring the pressure from 0.1 mTorr to 760 Torr. With adjustment of the porosity of the AAO, the measurable range could be extended toward lower pressures of more than one decade compared to a non-porous membrane with an identical footprint.

  13. Peristaltic pump-based low range pressure sensor calibration system.

    Science.gov (United States)

    Vinayakumar, K B; Naveen Kumar, G; Nayak, M M; Dinesh, N S; Rajanna, K

    2015-11-01

    Peristaltic pumps were normally used to pump liquids in several chemical and biological applications. In the present study, a peristaltic pump was used to pressurize the chamber (positive as well negative pressures) using atmospheric air. In the present paper, we discuss the development and performance study of an automatic pressurization system to calibrate low range (millibar) pressure sensors. The system includes a peristaltic pump, calibrated pressure sensor (master sensor), pressure chamber, and the control electronics. An in-house developed peristaltic pump was used to pressurize the chamber. A closed loop control system has been developed to detect and adjust the pressure leaks in the chamber. The complete system has been integrated into a portable product. The system performance has been studied for a step response and steady state errors. The system is portable, free from oil contaminants, and consumes less power compared to existing pressure calibration systems. The veracity of the system was verified by calibrating an unknown diaphragm based pressure sensor and the results obtained were satisfactory.

  14. Sensor Based Effective Monitoring of Coal Handling System (CHS

    Directory of Open Access Journals (Sweden)

    Kuttalakkani.M

    2013-06-01

    Full Text Available Coal level detection is an important aspect to assess the performance of a coal-fired power plant. Coal has to be transported, via a coal handling system. The fuel in a coal-fired power plant is stored in silos, bunkers or stock piles. Coal is stored in silos in a small plant, Bunkers for handling a day’s operation and Stock piling methods for large plants. So, fuel handling had to done efficiently. To accurately sense the coal height, Real-time feedback is deployed within the bunker or stock pile. The real time range information is then fedback to the control system. Of the different types of ranging sensors, radar based system is used. Also a real-time temperature monitoring system is developed to protect the coal. The range and temperature data from sensors are sent to the main system through GSM modem by means of SMS. The range information is used to start the conveyor belt to draw the coal from coal yard. If the temperature exceeds the limit, the SMS will be sent through the software or it will call the respective person to monitor the process. A fire sensor is also used to extinguish the fire by initiating the water spraying system. A PIC Microcontroller is interfaced all the sensors for effective handling of thermal power plant.

  15. Development of fluorescent FeIII sensor based on chalcone

    Energy Technology Data Exchange (ETDEWEB)

    Wei Yanli, E-mail: weiyanli@sxu.edu.cn [Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan 030006 (China); Qin Guojie [Institute of Horticulture, Shanxi Academy of Agriculture Science, Taiyuan 030031 (China); Wang Wenyan; Bian Wei; Shuang Shaomin [Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan 030006 (China); Dong Chuan, E-mail: dc@sxu.edu.cn [Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan 030006 (China)

    2011-08-15

    In this paper, 4-dimethylamino 2,5-dihydroxy chalcone (DMADHC), which exhibits excited state intramolecular charge transfer (ICT) characteristics, was synthesized and characterized. A sensitive optochemical sensor for Fe{sup 3+} ion was developed using DMADHC as fluorescence receptor. The fluorescence of DMADHC was gradually quenched with the addition of Fe{sup 3+} ion, which attributed to the formation of 1:1 complex between DMADHC and Fe{sup 3+} ion. The sensor exhibited excellent selectivity for Fe{sup 3+} ion over a large number of cation ions such as alkali, alkaline earth and transitional metal ions with a linear range of 3.984x10{sup -7}-1.135x10{sup -5} and a limit of detection of 8.223x10{sup -8} mol/L. On this basis, the sensor was preliminary applied to the determination of the content of iron ions in multi-vitamin tablet with satisfied results and the recoveries were in the 95-100% interval, and precision (n=5) was better than 5%. - Highlights: > A fluorescence receptor, 4-dimethylamino 2,5-dihydroxy chalcone was synthesis by one-step reaction. > Its intramolecular charge transfer fluorescence characteristics could be blocked by Fe{sup 3+} ion. > Based on this, an optochemical sensor for Fe{sup 3+} ion was developed. > Importantly, our proposed method is particularly useful for determination of Fe{sup 3+} ion in real sample.

  16. A Fiber Bragg Grating Sensing Based Triaxial Vibration Sensor.

    Science.gov (United States)

    Li, Tianliang; Tan, Yuegang; Liu, Yi; Qu, Yongzhi; Liu, Mingyao; Zhou, Zude

    2015-09-18

    A fiber Bragg grating (FBG) sensing based triaxial vibration sensor has been presented in this paper. The optical fiber is directly employed as elastomer, and the triaxial vibration of a measured body can be obtained by two pairs of FBGs. A model of a triaxial vibration sensor as well as decoupling principles of triaxial vibration and experimental analyses are proposed. Experimental results show that: sensitivities of 86.9 pm/g, 971.8 pm/g and 154.7 pm/g for each orthogonal sensitive direction with linearity are separately 3.64%, 1.50% and 3.01%. The flat frequency ranges reside in 20-200 Hz, 3-20 Hz and 4-50 Hz, respectively; in addition, the resonant frequencies are separately 700 Hz, 40 Hz and 110 Hz in the x/y/z direction. When the sensor is excited in a single direction vibration, the outputs of sensor in the other two directions are consistent with the outputs in the non-working state. Therefore, it is effectively demonstrated that it can be used for three-dimensional vibration measurement.

  17. ZnO Coated Nanospring-Based Gas Sensors

    Science.gov (United States)

    Bakharev, Pavel Viktorovich

    . The experimental and computational analyses of the sensing properties of the 3-D (nanospring-based) and flat thin films structures show that the complexity and periodic boundary conditions of the nanospring-based devices result in a lower detection limit, while flat thin films exhibit higher sensitivity to small analyte concentration fluctuations. Our analysis shows that the productive approach to fabrication of integrated sensors (electronic noses) is to use both the structures (3D and flat geometries) as the receptors for a prompt and reliable detection and recognition of the target chemical compounds. Analog lock-in amplifier (LIA) AC measurements of the electrical response have been performed to significantly improve the signal-to-noise ratio (SNR) and reduce the detection limit of the single ZnO coated nanospring chemiresistor from the ppm to the ppb analyte concentration ranges. The LIA-based sensor signal recognition technique has shown to extend the capabilities of the gas sensor array for a linear discrimination analysis (LDA), an independent component analysis (ICA), a principal component analysis (PCA) and other multiple odor recognition methods.

  18. DNA-Based Sensor for Real-Time Measurement of the Enzymatic Activity of Human Topoisomerase I

    DEFF Research Database (Denmark)

    Marcussen, Lærke Bay; Jepsen, Morten Leth; Kristoffersen, Emil Laust;

    2013-01-01

    . The basic design of the sensor relies on two DNA strands that hybridize to form a hairpin structure with a fluorophore-quencher pair. The quencher moiety is released from the sensor upon reaction with human topoisomerase I thus enabling real-time optical measurement of enzymatic activity. The sensor......Sensors capable of quantitative real-time measurements may present the easiest and most accurate way to study enzyme activities. Here we present a novel DNA-based sensor for specific and quantitative real-time measurement of the enzymatic activity of the essential human enzyme, topoisomerase I...... is specific for topoisomerase I even in raw cell extracts and presents a simple mean of following enzyme kinetics using standard laboratory equipment such as a qPCR machine or fluorimeter. Human topoisomerase I is a well-known target for the clinically used anti-cancer drugs of the camptothecin family...

  19. Sensitivity Analysis of a Bioinspired Refractive Index Based Gas Sensor

    Institute of Scientific and Technical Information of China (English)

    Yang Gao; Qi Xia; Guanglan Liao; Tielin Shi

    2011-01-01

    It was found out that the change of refractive index of ambient gas can lead to obvious change of the color of Morpho butterfly's wing. Such phenomenon has been employed as a sensing principle for detecting gas. In the present study, Rigorous Coupled-Wave Analysis (RCWA) was described briefly, and the partial derivative of optical reflection efficiency with respect to the refractive index of ambient gas, i.e., sensitivity of the sensor, was derived based on RCWA. A bioinspired grating model was constructed by mimicking the nanostructure on the ground scale of Morpho didius butterfly's wing. The analytical sensitivity was verified and the effect of the grating shape on the reflection spectra and its sensitivity were discussed. The results show that by tuning shape parameters of the grating, we can obtain desired reflection spectra and sensitivity, which can be applied to the design of the bioinspired refractive index based gas sensor.

  20. A Sensitive DNAzyme-Based Chiral Sensor for Lead Detection

    Directory of Open Access Journals (Sweden)

    Chuanlai Xu

    2013-11-01

    Full Text Available A DNAzyme-based sensor for the determination and quantification of lead ions (Pb2+ has been established, which combines the recognition and catalysis of DNAzyme with the optical properties of nanomaterials. Circular dichroism (CD signals were obtained by a DNAzyme-based assembly of asymmetric silver nanoparticle (AgNPs dimers. A good linear relationship between CD signals and Pb2+ concentration was obtained ranging from 0.05 ng∙mL−1 to 10 ng∙mL−1 with a limit of detection (LOD of 0.02 ng∙mL−1. The specificity of this sensor in lead ion detection was excellent, and a satisfactory recovery was obtained in the analysis of tap water samples. The proposed technique possesses both high sensitivity and good specificity, giving it great potential for the analysis of Pb2+ in water.

  1. Low-Cost Graphite-Based Free Chlorine Sensor.

    Science.gov (United States)

    Pan, Si; Deen, M Jamal; Ghosh, Raja

    2015-11-01

    Pencil lead was used to fabricate a graphite-based electrode for sensing applications. Its surface was electrochemically modified using ammonium carbamate to make it suitable for sensing free chlorine in water samples. Chlorine is widely used as a disinfectant in the water industry, and the residual free chlorine concentration in water distributed to the consumers must be lower than that stipulated by regulatory bodies. The graphite-based amperometric sensor gave a selective and linear response to free chlorine in the relevant concentration range and no response to commonly interfering ions. It was evaluated further for storage stability, response time, and hysteresis. This sensor is being proposed as a low-cost device for determining free chlorine in water samples. Its ease-of-use, limitations, and feasibility for mass-production and application is discussed.

  2. Comparison of CSMA based MAC protocols of wireless sensor networks

    CERN Document Server

    singh, Himanshu

    2012-01-01

    Energy conservation has been an important area of interest in Wireless Sensor networks (WSNs). Medium Access Control (MAC) protocols play an important role in energy conservation. In this paper, we describe CSMA based MAC protocols for WSN and analyze the simulation results of these protocols. We implemented S-MAC, T-MAC, B-MAC, B-MAC+, X-MAC, DMAC and Wise-MAC in TOSSIM, a simulator which unlike other simulators simulates the same code running on real hardware. Previous surveys mainly focused on the classification of MAC protocols according to the techniques being used or problem dealt with and presented a theoretical evaluation of protocols. This paper presents the comparative study of CSMA based protocols for WSNs, showing which MAC protocol is suitable in a particular environment and supports the arguments with the simulation results. The comparative study can be used to find the best suited MAC protocol for wireless sensor networks in different environments.

  3. AGV Trajectory Control Based on Laser Sensor Navigation

    Directory of Open Access Journals (Sweden)

    Thanh Luan Bui

    2013-01-01

    Full Text Available Autonomous Guided Vehicle Systems (AGVs are used to transport goods and products in manufacturing fields where navigation can be done in a structured environment. In order to track the given trajectory, a tracking control based on Lyapunov stability theory is introduced. The use of the nonlinear Lyapunov technique provides robustness for load disturbance and sensor noise. To apply Lyapunov's theorem, the kinematic model of AGV is given. To recognize its position in indoor environment, in this paper, a laser sensor device NAV200 is used to detect the AGV position in real-time. For simulation and experiment, software and hardware are described. The AGV consists of 4 wheels with two passive wheels and two driving wheels. A controller is developed based on industrial computer. The effectiveness of the proposed controller is proved by simulation and experimental results

  4. Planar Microwave Sensor for Theranostic Therapy of Organic Tissue Based on Oval Split Ring Resonators

    Directory of Open Access Journals (Sweden)

    Carolin Reimann

    2016-09-01

    Full Text Available Microwave sensors in medical environments play a significant role due to the contact-less and non-invasive sensing mechanism to determine dielectric properties of tissue. In this work, a theranostic sensor based on Split Ring Resonators (SRRs is presented that provides two operation modes to detect and treat tumor cells, exemplary in the liver. For the detection mode, resonance frequency changes due to abnormalities are evaluated, and in the treatment mode, microwave ablation is performed. The planar sensor structure can be integrated into a needle like a surgery tool that evokes challenges concerning size limitations and biocompatibility. To meet the size requirements and provide a reasonable operating frequency, properties of oval shaped SRRs are investigated. By elongating the radius of the SRR in one direction, the resonance frequency can be decreased significantly compared to circular SRR by a factor of two below 12 GHz. In order to validate the detection and treatment characteristics of the sensor, full wave simulations and measurements are examined. Clear resonance shifts are detected for loading the sensor structures with phantoms mimicking healthy and malignant tissue. For treatment mode evaluation, ex vivo beef liver tissue was ablated leading to a lesion zone 1.2 cm × 1 cm × 0.3 cm with a three minute exposure of maximum 2.1 W.

  5. Planar Microwave Sensor for Theranostic Therapy of Organic Tissue Based on Oval Split Ring Resonators.

    Science.gov (United States)

    Reimann, Carolin; Puentes, Margarita; Maasch, Matthias; Hübner, Frank; Bazrafshan, Babak; Vogl, Thomas J; Damm, Christian; Jakoby, Rolf

    2016-09-08

    Microwave sensors in medical environments play a significant role due to the contact-less and non-invasive sensing mechanism to determine dielectric properties of tissue. In this work, a theranostic sensor based on Split Ring Resonators (SRRs) is presented that provides two operation modes to detect and treat tumor cells, exemplary in the liver. For the detection mode, resonance frequency changes due to abnormalities are evaluated, and in the treatment mode, microwave ablation is performed. The planar sensor structure can be integrated into a needle like a surgery tool that evokes challenges concerning size limitations and biocompatibility. To meet the size requirements and provide a reasonable operating frequency, properties of oval shaped SRRs are investigated. By elongating the radius of the SRR in one direction, the resonance frequency can be decreased significantly compared to circular SRR by a factor of two below 12 GHz. In order to validate the detection and treatment characteristics of the sensor, full wave simulations and measurements are examined. Clear resonance shifts are detected for loading the sensor structures with phantoms mimicking healthy and malignant tissue. For treatment mode evaluation, ex vivo beef liver tissue was ablated leading to a lesion zone 1.2 cm × 1 cm × 0.3 cm with a three minute exposure of maximum 2.1 W.

  6. A ph sensor based on a flexible substrate

    Science.gov (United States)

    Huang, Wen-Ding

    pH sensor is an essential component used in many chemical, food, and bio-material industries. Conventional glass electrodes have been used to construct pH sensors, however, have some disadvantages. Glass electrodes are easily affected by alkaline or HF solution, they require a high input impedance pH meter, they often exhibit a sluggish response. In some specific applications, it is also difficult to use glass electrodes for in vivo biomedical or food monitoring applications due to the difficulty of size miniaturization, planarization and polymerization based on current manufacturing technologies. In this work, we have demonstrated a novel flexible pH sensor based on low-cost sol-gel fabrication process of iridium oxide (IrOx) sensing film (IROF). A pair of flexible miniature IrOx/AgCl electrode generated the action potential from the solution by electrochemical mechanism to obtain the pH level of the reagent. The fabrication process including sol-gel, thermal oxidation, and the electro-plating process of the silver chloride (AgCl) reference electrode were reported in the work. The IrOx film was verified and characterized using electron dispersive analysis (EDAX), scanning electron microscope (SEM), and x-ray diffraction (XRD). The flexible pH sensor's performance and characterization have been investigated with different testing parameters such as sensitivity, response time, stability, reversibility, repeatability, selectivity and temperature dependence. The flexible IrOx pH sensors exhibited promising sensing performance with a near-Nernstian response of sensitivity which is between --51.1mV/pH and --51.7mV/pH in different pH levels ranging from 1.5 to 12 at 25°C. Two applications including gastroesophageal reflux disease (GERD) diagnosis and food freshness wireless monitoring using our micro-flexible IrOx pH sensors were demonstrated. For the GERD diagnosing system, we embedded the micro flexible pH sensor on a 1.2cmx3.8cm of the capsule size of wireless sensor

  7. Nanotube-based Sensors and Systems for Outer Planetary Exploration

    Science.gov (United States)

    Noca, F.; Hunt, B. D.; Hoenk, M. E.; Choi, D.; Kowalczyk, R.; Williams, R.; Xu, J.; Koumoutsakos, P.

    2001-01-01

    Direct sensing and processing at the nanometer scale offer NASA the opportunity to expand its capabilities in deep space exploration, particularly for the search for signatures of life, the analysis of planetary oceans and atmospheres, and communications systems. Carbon nanotubes, with their unique mechanical, electrical, and radiation-tolerant properties, are a promising tool for this exploration. We are developing devices based on carbon nanotubes, including sensors, actuators, and oscillators. Additional information is contained in the original extended abstract.

  8. Research of optical rainfall sensor based on CCD linear array

    Institute of Scientific and Technical Information of China (English)

    YANG; Bifeng; LIU; Yuyan; LU; Ying; WU; Shangqian

    2015-01-01

    Rainfall monitoring is one of the most important meteorological observation elements for the disaster weather. The maintenance of current tipping bucket rain gauge and weighing type rain gauge is a critical issue. The optical rainfall sensor based on CCD linear array is mainly studied in this paper. Because of the maintenance-free time and good adaptability,it can be widely used in the automatic rainfall monitoring in severe environment and have a good perspective in using.

  9. Hydrogen sensor based on metallic photonic crystal slabs.

    Science.gov (United States)

    Nau, D; Seidel, A; Orzekowsky, R B; Lee, S-H; Deb, S; Giessen, H

    2010-09-15

    We present a hydrogen sensor based on metallic photonic crystal slabs. Tungsten trioxide (WO(3)) is used as a waveguide layer below an array of gold nanowires. Hydrogen exposure influences the optical properties of this photonic crystal arrangement by gasochromic mechanisms, where the photonic crystal geometry leads to sharp spectral resonances. Measurements reveal a change of the transmission depending on the hydrogen concentration. Theoretical limits for the detection range and sensitivity of this approach are discussed.

  10. Plasmonic Sensors Based on Doubly-Deposited Tapered Optical Fibers

    Directory of Open Access Journals (Sweden)

    Agustín González-Cano

    2014-03-01

    Full Text Available A review of the surface plasmon resonance (SPR transducers based on tapered fibers that have been developed in the last years is presented. The devices have proved their good performance (specifically, in terms of sensitivity and their versatility and they are a very good option to be considered as basis for any kind of chemical and biological sensor. The technology has now reached its maturity and here we summarize some of the characteristics of the devices produced.

  11. Micro electro mechanical systems based sensor for mechanomyography

    OpenAIRE

    Murphy, Chris; Campbell, Niall; Caulfield, Brian; Ward, Tomas; Deegan, Catherine

    2008-01-01

    The purpose of this work was to design a micro electrical mechanical sensor (MEMS) based system to measure the mechanomyogram of electrically stimulated muscle. The measuring device for the mechanomyography (MMG) system consisted of a dual axis accelerometer and a signal conditioning circuit designed specifically to enhance raw MMG signals . Currently electromyography (EMG) is the standard tool for measuring muscle contraction. During electrical stimulation however, EMG measure...

  12. An Astigmatic Detection System for Polymeric Cantilever-based Sensors

    DEFF Research Database (Denmark)

    Hwu, En-Te; Liao, Hsien-Shun; Bosco, Filippo;

    2012-01-01

    We demonstrate the use of an astigmatic detection system (ADS) for resonance frequency identification of polymer microcantilever sensors. The ADS technology is based on a DVD optical head combined with an optical microscope (OM). The optical head has a signal bandwidth of 80 MHz, allowing thermal...... submicrometer-sized cantilevers. The resonant frequency of SU-8 microcantilevers is measured by both thermal fluctuation and excited vibration measurement modes of the ADS....

  13. Graphene Based Electrochemical Sensors and Biosensors: A Review

    Energy Technology Data Exchange (ETDEWEB)

    Shao, Yuyan; Wang, Jun; Wu, Hong; Liu, Jun; Aksay, Ilhan A.; Lin, Yuehe

    2010-05-01

    Graphene, emerging as a true 2-dimensional material, has received increasing attention due to its unique physicochemical properties (high surface area, excellent conductivity, high mechanical strength, and ease of functionalization and mass production). This article selectively reviews recent advances in graphene-based electrochemical sensors and biosensors. In particular, graphene for direct electrochemistry of enzyme, its electrocatalytic activity toward small biomolecules (hydrogen peroxide, NADH, dopamine, etc.), and graphene-based enzyme biosensors have been summarized in more detail; Graphene-based DNA sensing and environmental analysis have been discussed. Future perspectives in this rapidly developing field are also discussed.

  14. Building SDN-Based Agricultural Vehicular Sensor Networks Based on Extended Open vSwitch.

    Science.gov (United States)

    Huang, Tao; Yan, Siyu; Yang, Fan; Pan, Tian; Liu, Jiang

    2016-01-19

    Software-defined vehicular sensor networks in agriculture, such as autonomous vehicle navigation based on wireless multi-sensor networks, can lead to more efficient precision agriculture. In SDN-based vehicle sensor networks, the data plane is simplified and becomes more efficient by introducing a centralized controller. However, in a wireless environment, the main controller node may leave the sensor network due to the dynamic topology change or the unstable wireless signal, leaving the rest of network devices without control, e.g., a sensor node as a switch may forward packets according to stale rules until the controller updates the flow table entries. To solve this problem, this paper proposes a novel SDN-based vehicular sensor networks architecture which can minimize the performance penalty of controller connection loss. We achieve this by designing a connection state detection and self-learning mechanism. We build prototypes based on extended Open vSwitch and Ryu. The experimental results show that the recovery time from controller connection loss is under 100 ms and it keeps rule updating in real time with a stable throughput. This architecture enhances the survivability and stability of SDN-based vehicular sensor networks in precision agriculture.

  15. Building SDN-Based Agricultural Vehicular Sensor Networks Based on Extended Open vSwitch

    Directory of Open Access Journals (Sweden)

    Tao Huang

    2016-01-01

    Full Text Available Software-defined vehicular sensor networks in agriculture, such as autonomous vehicle navigation based on wireless multi-sensor networks, can lead to more efficient precision agriculture. In SDN-based vehicle sensor networks, the data plane is simplified and becomes more efficient by introducing a centralized controller. However, in a wireless environment, the main controller node may leave the sensor network due to the dynamic topology change or the unstable wireless signal, leaving the rest of network devices without control, e.g., a sensor node as a switch may forward packets according to stale rules until the controller updates the flow table entries. To solve this problem, this paper proposes a novel SDN-based vehicular sensor networks architecture which can minimize the performance penalty of controller connection loss. We achieve this by designing a connection state detection and self-learning mechanism. We build prototypes based on extended Open vSwitch and Ryu. The experimental results show that the recovery time from controller connection loss is under 100 ms and it keeps rule updating in real time with a stable throughput. This architecture enhances the survivability and stability of SDN-based vehicular sensor networks in precision agriculture.

  16. Hierarchical Compressed Sensing for Cluster Based Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Vishal Krishna Singh

    2016-02-01

    Full Text Available Data transmission consumes significant amount of energy in large scale wireless sensor networks (WSNs. In such an environment, reducing the in-network communication and distributing the load evenly over the network can reduce the overall energy consumption and maximize the network lifetime significantly. In this work, the aforementioned problem of network lifetime and uneven energy consumption in large scale wireless sensor networks is addressed. This work proposes a hierarchical compressed sensing (HCS scheme to reduce the in-network communication during the data gathering process. Co-related sensor readings are collected via a hierarchical clustering scheme. A compressed sensing (CS based data processing scheme is devised to transmit the data from the source to the sink. The proposed HCS is able to identify the optimal position for the application of CS to achieve reduced and similar number of transmissions on all the nodes in the network. An activity map is generated to validate the reduced and uniformly distributed communication load of the WSN. Based on the number of transmissions per data gathering round, the bit-hop metric model is used to analyse the overall energy consumption. Simulation results validate the efficiency of the proposed method over the existing CS based approaches.

  17. Efficient Vector-Based Forwarding for Underwater Sensor Networks

    Directory of Open Access Journals (Sweden)

    Peng Xie

    2010-01-01

    Full Text Available Underwater Sensor Networks (UWSNs are significantly different from terrestrial sensor networks in the following aspects: low bandwidth, high latency, node mobility, high error probability, and 3-dimensional space. These new features bring many challenges to the network protocol design of UWSNs. In this paper, we tackle one fundamental problem in UWSNs: robust, scalable, and energy efficient routing. We propose vector-based forwarding (VBF, a geographic routing protocol. In VBF, the forwarding path is guided by a vector from the source to the target, no state information is required on the sensor nodes, and only a small fraction of the nodes is involved in routing. To improve the robustness, packets are forwarded in redundant and interleaved paths. Further, a localized and distributed self-adaptation algorithm allows the nodes to reduce energy consumption by discarding redundant packets. VBF performs well in dense networks. For sparse networks, we propose a hop-by-hop vector-based forwarding (HH-VBF protocol, which adapts the vector-based approach at every hop. We evaluate the performance of VBF and HH-VBF through extensive simulations. The simulation results show that VBF achieves high packet delivery ratio and energy efficiency in dense networks and HH-VBF has high packet delivery ratio even in sparse networks.

  18. Intent-based resource deployment in wireless sensor networks

    Science.gov (United States)

    de Mel, Geeth; Pham, Tien; Sullivan, Paul; Grueneberg, Keith; Vasconcelos, Wamberto; Norman, Tim

    2012-06-01

    Information derived from sensor networks plays a crucial role in the success of many critical tasks such as surveillance, and border monitoring. In order to derive the correct information at the right time, sensor data must be captured at desired locations with respect to the operational tasks in concern. Therefore, it is important that at the planning stage of a mission, sensing resources are best placed in the field to capture the required data. For example, consider a mission goal identify snipers, in an operational area before troops are deployed - two acoustic arrays and a day-night video camera are needed to successfully achieve this goal. This is because, if the resources are placed in correct locations, two acoustic arrays could provide direction of the shooter and a possible location by triangulating acoustic data whereas the day-night camera could produce an affirmative image of the perpetrators. In order to deploy the sensing resources intelligently to support the user decisions, in this paper we propose a Semantic Web based knowledge layer to identify the required resources in a sensor network and deploy the needed resources through a sensor infrastructure. The knowledge layer captures crucial information such as resources configurations, their intended use (e.g., two acoustic arrays deployed in a particular formation with day-night camera are needed to identify perpetrators in a possible sniper attack). The underlying sensor infrastructure will assists the process by exposing the information about deployed resources, resources in theatre, and location information about tasks, resources and so on.

  19. Cell-bionics: tools for real-time sensor processing.

    Science.gov (United States)

    Toumazou, Chris; Cass, Tony

    2007-08-29

    The accurate monitoring of the physiological status of cells, tissues and whole organisms demands a new generation of devices capable of providing accurate data in real time with minimal perturbation of the system being measured. To deliver on the promise of cell-bionics advances over the past decade in miniaturization, analogue signal processing, low-power electronics, materials science and protein engineering need to be brought together. In this paper we summarize recent advances in our research that is moving us in this direction. Two areas in particular are highlighted: the exploitation of the physical properties inherent in semiconductor devices to perform very low power on chip signal processing and the use of gene technology to tailor proteins for sensor applications. In the context of engineered tissues, cell-bionics could offer the ability to monitor the precise physiological state of the construct, both during 'manufacture' and post-implantation. Monitoring during manufacture, particularly by embedded devices, would offer quality assurance of the materials components and the fabrication process. Post-implantation monitoring would reveal changes in the underlying physiology as a result of the tissue construct adapting to its new environment.

  20. Nano-based sensor for assessment of weaponry structural degradation

    Science.gov (United States)

    Brantley, Christina L.; Edwards, Eugene; Ruffin, Paul B.; Kranz, Michael

    2016-04-01

    Missiles and weaponry-based systems are composed of metal structures that can degrade after prolonged exposure to environmental elements. A particular concern is accumulation of corrosion that generally results from prolonged environmental exposure. Corrosion, defined as the unintended destruction or deterioration of a material due to its interaction with the environment, can negatively affect both equipment and infrastructure. System readiness and safety can be reduced if corrosion is not detected, prevented and managed. The current corrosion recognition methods (Visual, Radiography, Ultrasonics, Eddy Current, and Thermography) are expensive and potentially unreliable. Visual perception is the most commonly used method for determining corrosion in metal. Utilization of an inductance-based sensor system is being proposed as part of the authors' research. Results from this research will provide a more efficient, economical, and non-destructive sensing approach. Preliminary results demonstrate a highly linear degradation within a corrosive environment due to the increased surface area available on the sensor coupon. The inductance of the devices, which represents a volume property of the coupon, demonstrated sensitivity to corrosion levels. The proposed approach allows a direct mass-loss measurement based on the change in the inductance of the coupon when placed in an alternating magnetic field. Prototype devices have demonstrated highly predictable corrosion rates that are easily measured using low-power small electronic circuits and energy harvesting methods to interrogate the sensor. Preliminary testing demonstrates that the device concept is acceptable and future opportunities for use in low power embedded applications are achievable. Key results in this paper include the assessment of typical Army corrosion cost, degradation patterns of varying metal materials, and application of wireless sensors elements.

  1. A fuzzy behaviorist approach to sensor-based robot control

    Energy Technology Data Exchange (ETDEWEB)

    Pin, F.G.

    1996-05-01

    Sensor-based operation of autonomous robots in unstructured and/or outdoor environments has revealed to be an extremely challenging problem, mainly because of the difficulties encountered when attempting to represent the many uncertainties which are always present in the real world. These uncertainties are primarily due to sensor imprecisions and unpredictability of the environment, i.e., lack of full knowledge of the environment characteristics and dynamics. An approach. which we have named the {open_quotes}Fuzzy Behaviorist Approach{close_quotes} (FBA) is proposed in an attempt to remedy some of these difficulties. This approach is based on the representation of the system`s uncertainties using Fuzzy Set Theory-based approximations and on the representation of the reasoning and control schemes as sets of elemental behaviors. Using the FBA, a formalism for rule base development and an automated generator of fuzzy rules have been developed. This automated system can automatically construct the set of membership functions corresponding to fuzzy behaviors. Once these have been expressed in qualitative terms by the user. The system also checks for completeness of the rule base and for non-redundancy of the rules (which has traditionally been a major hurdle in rule base development). Two major conceptual features, the suppression and inhibition mechanisms which allow to express a dominance between behaviors are discussed in detail. Some experimental results obtained with the automated fuzzy, rule generator applied to the domain of sensor-based navigation in aprion unknown environments. using one of our autonomous test-bed robots as well as a real car in outdoor environments, are then reviewed and discussed to illustrate the feasibility of large-scale automatic fuzzy rule generation using the {open_quotes}Fuzzy Behaviorist{close_quotes} concepts.

  2. Using Custom Fiber Bragg Grating-Based Sensors to Monitor Artificial Landslides

    Science.gov (United States)

    Zhang, Qinghua; Wang, Yuan; Sun, Yangyang; Gao, Lei; Zhang, Zhenglin; Zhang, Wenyuan; Zhao, Pengchong; Yue, Yin

    2016-01-01

    Four custom fiber Bragg grating (FBG)-based sensors are developed to monitor an artificial landslide located in Nanjing, China. The sensors are composed of a rod and two FBGs. Based on the strength of the rods, two sensors are referred to as “hard sensors” (Sensor 1 and Sensor 2), the other two are referred to as “soft sensors” (Sensor 3 and Sensor 4). The two FBGs are fixed on each sensor rod at distances of 50 cm and 100 cm from the top of the rod (an upper FBG and a lower FBG). In the experiment presented in this paper, the sensors are installed on a slope on which an artificial landslide is generated through both machine-based and manual excavation. The fiber sensing system consists of the four custom FBG-based sensors, optical fiber, a static fiber grating demodulation instrument (SM125), and a PC with the necessary software. Experimental data was collected in the presence of an artificial landslide, and the results show that the lower FBGs are more sensitive than the upper FBGs for all four of the custom sensors. It was also found that Sensor 2 and Sensor 4 are more capable of monitoring small-scale landslides than Sensor 1 and Sensor 3, and this is mainly due to their placement location with respect to the landslide. The stronger rods used in the hard sensors make them more adaptable to the harsh environments of large landslides. Thus, hard sensors should be fixed near the landslide, while soft sensors should be placed farther away from the landslide. In addition, a clear tendency of strain variation can be detected by the soft sensors, which can be used to predict landslides and raise a hazard alarm. PMID:27598163

  3. CO responses of sensors based on cerium oxide thick films prepared from clustered spherical nanoparticles.

    Science.gov (United States)

    Izu, Noriya; Matsubara, Ichiro; Itoh, Toshio; Akamatsu, Takafumi; Shin, Woosuck

    2013-03-08

    Various types of CO sensors based on cerium oxide (ceria) have been reported recently. It has also been reported that the response speed of CO sensors fabricated from porous ceria thick films comprising nanoparticles is extremely high. However, the response value of such sensors is not suitably high. In this study, we investigated methods of improving the response values of CO sensors based on ceria and prepared gas sensors from core-shell ceria polymer hybrid nanoparticles. These hybrid nanoparticles have been reported to have a unique structure: The core consists of a cluster of ceria crystallites several nanometers in size. We compared the characteristics of the sensors based on thick films prepared from core-shell nanoparticles with those of sensors based on thick films prepared from conventionally used precipitated nanoparticles. The sensors prepared from the core-shell nanoparticles exhibited a resistance that was ten times greater than that of the sensors prepared from the precipitated nanoparticles. The response values of the gas sensors based on the core-shell nanoparticles also was higher than that of the sensors based on the precipitated nanoparticles. Finally, improvements in sensor response were also noticed after the addition of Au nanoparticles to the thick films used to fabricate the two types of sensors.

  4. Miniature fiber optic sensor based on fluorescence energy transfer

    Science.gov (United States)

    Meadows, David L.; Schultz, Jerome S.

    1992-04-01

    Optical fiber biosensors based on fluorescence assays have several distinct advantages when measuring biological analytes such as metabolites, cofactors, toxins, etc. Not only are optical signals immune to electronic interferences, but the polychromatic nature of most fluorochemical assays provides more potentially useful data about the system being studied. One of the most common difficulties normally encountered with optical biosensors is the inability to routinely recalibrate the optical and electronic components of the system throughout the life of the sensor. With this in mind, we present an optical fiber assay system for glucose based on a homogeneous singlet/singlet energy transfer assay along with the electronic instrumentation built to support the sensor system. In the sensor probe, glucose concentrations are indirectly measured from the level of fluorescence quenching caused by the homogeneous competition assay between TRITC labeled concanavalin A (receptor) and FITC labeled Dextran (ligand). The FITC signal is used to indicate glucose concentrations and the TRITC signal is used for internal calibration. Data is also presented on a protein derivatization procedure that was used to prevent aggregation of the receptor protein in solution. Also, a molecular model is described for the singlet/singlet energy transfer interactions that can occur in a model system composed of a monovalent ligand (FITC labeled papain) and a monovalent receptor (TRITC labeled concanavalin A).

  5. Mobility-based Time References for Wireless Sensor Networks

    CERN Document Server

    Sebastiano, Fabio; Makinwa, Kofi A A

    2013-01-01

     This book describes the use of low-power low-cost and extremely small radios to provide essential time reference for wireless sensor networks.  The authors explain how to integrate such radios in a standard CMOS process to reduce both cost and size, while focusing on the challenge of designing a fully integrated time reference for such radios. To enable the integration of the time reference, system techniques are proposed and analyzed, several kinds of integrated time references are reviewed, and mobility-based references are identified as viable candidates to provide the required accuracy at low-power consumption. Practical implementations of a mobility-based oscillator and a temperature sensor are also presented, which demonstrate the required accuracy over a wide temperature range, while drawing 51-uW from a 1.2-V supply in a 65-nm CMOS process. Provides system analysis to understand requirements for time/frequency accuracy in wireless sensor networks; Describes system optimization for time references i...

  6. Noninvasive Temperature Measurement Based on Microwave Temperature Sensor

    Directory of Open Access Journals (Sweden)

    Shoucheng Ding

    2013-01-01

    Full Text Available In this study, we have a research of the noninvasive temperature measurement based on microwave temperature sensor. Moreover, in order to solve the surface temperature measurement for designing microwave temperature sensor, the microwave was issued by the transmitting antenna. Microwave encountered by the measured object to return back to the measured object and then convert it into electrical signals, the use of the quantitative relationship between this signal and input noise temperature to real-time calibration. In order to calculate the antenna brightness temperature and then after signal conditioning circuit, which can show the temperature value, in order to achieve the detection of microwave temperature. Microwave-temperature measurement system hardware based on 89C51 microcontroller consists of the microwave temperature sensor, signal conditioning circuitry and chip control circuit, AD converter circuit and display circuit. The system software is by the main program, the AD conversion routines, subroutines and delay subprogram. The microwave temperature measurement characterize has: without gain fluctuations, without the impact of changes in the noise of the machine, to provide continuous calibration, wide dynamic range.

  7. Vision Sensor-Based Road Detection for Field Robot Navigation.

    Science.gov (United States)

    Lu, Keyu; Li, Jian; An, Xiangjing; He, Hangen

    2015-11-24

    Road detection is an essential component of field robot navigation systems. Vision sensors play an important role in road detection for their great potential in environmental perception. In this paper, we propose a hierarchical vision sensor-based method for robust road detection in challenging road scenes. More specifically, for a given road image captured by an on-board vision sensor, we introduce a multiple population genetic algorithm (MPGA)-based approach for efficient road vanishing point detection. Superpixel-level seeds are then selected in an unsupervised way using a clustering strategy. Then, according to the GrowCut framework, the seeds proliferate and iteratively try to occupy their neighbors. After convergence, the initial road segment is obtained. Finally, in order to achieve a globally-consistent road segment, the initial road segment is refined using the conditional random field (CRF) framework, which integrates high-level information into road detection. We perform several experiments to evaluate the common performance, scale sensitivity and noise sensitivity of the proposed method. The experimental results demonstrate that the proposed method exhibits high robustness compared to the state of the art.

  8. Vision Sensor-Based Road Detection for Field Robot Navigation

    Directory of Open Access Journals (Sweden)

    Keyu Lu

    2015-11-01

    Full Text Available Road detection is an essential component of field robot navigation systems. Vision sensors play an important role in road detection for their great potential in environmental perception. In this paper, we propose a hierarchical vision sensor-based method for robust road detection in challenging road scenes. More specifically, for a given road image captured by an on-board vision sensor, we introduce a multiple population genetic algorithm (MPGA-based approach for efficient road vanishing point detection. Superpixel-level seeds are then selected in an unsupervised way using a clustering strategy. Then, according to the GrowCut framework, the seeds proliferate and iteratively try to occupy their neighbors. After convergence, the initial road segment is obtained. Finally, in order to achieve a globally-consistent road segment, the initial road segment is refined using the conditional random field (CRF framework, which integrates high-level information into road detection. We perform several experiments to evaluate the common performance, scale sensitivity and noise sensitivity of the proposed method. The experimental results demonstrate that the proposed method exhibits high robustness compared to the state of the art.

  9. Cooperative Opportunistic Pressure Based Routing for Underwater Wireless Sensor Networks.

    Science.gov (United States)

    Javaid, Nadeem; Muhammad; Sher, Arshad; Abdul, Wadood; Niaz, Iftikhar Azim; Almogren, Ahmad; Alamri, Atif

    2017-03-19

    In this paper, three opportunistic pressure based routing techniques for underwater wireless sensor networks (UWSNs) are proposed. The first one is the cooperative opportunistic pressure based routing protocol (Co-Hydrocast), second technique is the improved Hydrocast (improved-Hydrocast), and third one is the cooperative improved Hydrocast (Co-improved Hydrocast). In order to minimize lengthy routing paths between the source and the destination and to avoid void holes at the sparse networks, sensor nodes are deployed at different strategic locations. The deployment of sensor nodes at strategic locations assure the maximum monitoring of the network field. To conserve the energy consumption and minimize the number of hops, greedy algorithm is used to transmit data packets from the source to the destination. Moreover, the opportunistic routing is also exploited to avoid void regions by making backward transmissions to find reliable path towards the destination in the network. The relay cooperation mechanism is used for reliable data packet delivery, when signal to noise ratio (SNR) of the received signal is not within the predefined threshold then the maximal ratio combining (MRC) is used as a diversity technique to improve the SNR of the received signals at the destination. Extensive simulations validate that our schemes perform better in terms of packet delivery ratio and energy consumption than the existing technique; Hydrocast.

  10. Fiber-Optic Vibration Sensor Based on Multimode Fiber

    Directory of Open Access Journals (Sweden)

    I. Lujo

    2008-06-01

    Full Text Available The purpose of this paper is to present a fiberoptic vibration sensor based on the monitoring of the mode distribution in a multimode optical fiber. Detection of vibrations and their parameters is possible through observation of the output speckle pattern from the multimode optical fiber. A working experimental model has been built in which all used components are widely available and cheap: a CCD camera (a simple web-cam, a multimode laser in visible range as a light source, a length of multimode optical fiber, and a computer for signal processing. Measurements have shown good agreement with the actual frequency of vibrations, and promising results were achieved with the amplitude measurements although they require some adaptation of the experimental model. Proposed sensor is cheap and lightweight and therefore presents an interesting alternative for monitoring large smart structures.

  11. Measurement system for nitrous oxide based on amperometric gas sensor

    Science.gov (United States)

    Siswoyo, S.; Persaud, K. C.; Phillips, V. R.; Sneath, R.

    2017-03-01

    It has been well known that nitrous oxide is an important greenhouse gas, so monitoring and control of its concentration and emission is very important. In this work a nitrous oxide measurement system has been developed consisting of an amperometric sensor and an appropriate lab-made potentiostat that capable measuring picoampere current ranges. The sensor was constructed using a gold microelectrode as working electrode surrounded by a silver wire as quasi reference electrode, with tetraethyl ammonium perchlorate and dimethylsulphoxide as supporting electrolyte and solvent respectively. The lab-made potentiostat was built incorporating a transimpedance amplifier capable of picoampere measurements. This also incorporated a microcontroller based data acquisition system, controlled by a host personal computer using a dedicated computer program. The system was capable of detecting N2O concentrations down to 0.07 % v/v.

  12. Numeral eddy current sensor modelling based on genetic neural network

    Institute of Scientific and Technical Information of China (English)

    Yu A-Long

    2008-01-01

    This paper presents a method used to the numeral eddy current sensor modelling based on the genetic neural network to settle its nonlinear problem. The principle and algorithms of genetic neural network are introduced. In this method, the nonlinear model parameters of the numeral eddy current sensor are optimized by genetic neural network (GNN) according to measurement data. So the method remains both the global searching ability of genetic algorithm and the good local searching ability of neural network. The nonlinear model has the advantages of strong robustness,on-line modelling and high precision.The maximum nonlinearity error can be reduced to 0.037% by using GNN.However, the maximum nonlinearity error is 0.075% using the least square method.

  13. Polymer-Based Self-Standing Flexible Strain Sensor

    Directory of Open Access Journals (Sweden)

    Fernando Martinez

    2010-01-01

    Full Text Available The design and characterization of polymer-based self-standing flexible strain sensors are presented in this work. Properties as lightness and flexibility make them suitable for the measurement of strain in applications related with wearable electronics such as robotics or rehabilitation devices. Several sensors have been fabricated to analyze the influence of size and electrical conductivity on their behavior. Elongation and applied charge were precisely controlled in order to measure different parameters as electrical resistance, gauge factor (GF, hysteresis, and repeatability. The results clearly show the influence of size and electrical conductivity on the gauge factor, but it is also important to point out the necessity of controlling the hysteresis and repeatability of the response for precision-demanding applications.

  14. Identity-based Trusted Authentication in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Yusnani Mohd Yussoff

    2012-05-01

    Full Text Available Secure communication mechanisms in Wireless Sensor Networks (WSNs have been widely deployed to ensure confidentiality, authenticity and integrity of the nodes and data. Recently many WSNs applications rely on trusted communication to ensure large user acceptance. Indeed, the trusted relationship thus far can only be achieved through Trust Management System (TMS or by adding external security chip on the WSN platform. In this study an alternative mechanism is proposed to accomplish trusted communication between sensors based on the principles defined by Trusted Computing Group (TCG. The results of other related study have also been analyzed to validate and support our findings. Finally the proposed trusted mechanism is evaluated for the potential application on resource constraint devices by quantifying their power consumption on selected major processes. The result proved the proposed scheme can establish trust in WSN with less computation and communication and most importantly eliminating the need for neighboring evaluation for TMS or relying on external security chip.

  15. A Peptoid-Based Fluorescent Sensor for Cyanide Detection

    Directory of Open Access Journals (Sweden)

    Bumhee Lim

    2016-03-01

    Full Text Available Peptoids, N-substituted glycine oligomers, are versatile peptidomimetics with diverse biomedical applications. However, strategies to the development of novel fluorescent peptoids as chemical sensors have not been extensively explored, yet. Here, we synthesized a novel peptoid-based fluorescent probe in which a coumarin moiety was incorporated via copper(I-catalyzed azide-alkyne cycloaddition reaction. Fluorescence of the newly generated coumarin-peptoid was dramatically quenched upon coordination of the Cu2+ ion, and the resulting peptoid-Cu2+ complex exhibited significant Turn-ON fluorescence following the addition of CN−. The rapid and reversible response, combined with cyanide selectivity of the synthesized peptoid, reflects a multistep photo-process and supports its utility as a new type of CN− sensor.

  16. Human Ensuing Self-balancing Automaton Based on Motion Sensor

    Directory of Open Access Journals (Sweden)

    R. Kishhanth

    2014-10-01

    Full Text Available Travel has become one among rudimentary necessities for every individual. Handling baggage plays an important role while travelling and for typical nomads it is cumbersome when heavy. With the proposed concept which will be dealt in this study, the baggage need not be pulled by us; it just follows us detecting our presence. Hence, the baggage is simply nothing but a robot. Prototype of motion sensor based human following robot that can balance itself in two wheels, thus behaving as a suitcase with intelligence and hence named Smart Suitcase. Concept of inverted pendulum helps in balancing. Regenerative power saving is established, when on its normal movement by the user wherein the saved power can be used for charging mobiles, laptops, torch lights etc. (low voltage applications. Passive infrared sensors fed with inbuilt intelligence in responding only to human presence helps this robot get even smarter.

  17. Methane sensor based on palladium/MWNT nanocomposites

    Institute of Scientific and Technical Information of China (English)

    Zhong Ping Li; Yong Guo; Suo Zhu Wu; Shao Min Shuang; Chuan Dong

    2009-01-01

    Methane gas sensor was fabricated based on electrocatalytic properties of the Pd/MWNT nanocomposites on indium tin oxide (ITO) glass substrates.A linear response for methane was obtained in the range of 0-16% (v/v) with a detection limit of 0.167% (v/v) and R.S.D.of 4.1%.After 100 times sensing or stable stored more than 12 months in atmosphere,unconspicuous measurable decrease was observed.The response time was less than 60 s at room temperature and ambient pressure.Some common potential interferents in samples such as N2,CO,CO2,ethane,propane,pentane,methanol,ethanol,H2 and NH3 were investigated and all the effects were less than 5% on the response for 3.0% (v/v) methane.The sensor was applied to methane determinations in man-made gas samples,the results are satisfied.

  18. Optical fiber temperature sensor based on wavelength-dependent detection

    Institute of Scientific and Technical Information of China (English)

    Zhigang Li(李志刚); Zhenhui Du(杜振辉); Baoguang Wang(王宝光); Chengzhi Jiang(蒋诚志)

    2004-01-01

    Semiconductor fiber temperature sensors have been used widely in many fields, but most of them pick up temperature by measuring the optical intensity of certain fixed narrow-band in absorption spectrum.Furthermore, they are sensitive to the loss of optical intensity and the fluctuation of light source power.The novel temperature measurement system proposed in this paper is based on the semiconductor absorption theory and the spectral analysis of method. To measure temperature, the sensor model detects not the certain narrow-band spectrum but the most spectra of the optical absorption edge. Therefore the measurement accuracy and the stability can be improved greatly. Experimental results are in agreement with theoretical analysis results perfectly.

  19. An Optical Fibre-Based Sensor for Respiratory Monitoring

    Directory of Open Access Journals (Sweden)

    Marek Krehel

    2014-07-01

    Full Text Available In this paper, a textile-based respiratory sensing system is presented. Highly flexible polymeric optical fibres (POFs that react to applied pressure were integrated into a carrier fabric to form a wearable sensing system. After the evaluation of different optical fibres, different setups were compared. To demonstrate the feasibility of such a wearable sensor, the setup featuring the best performance was placed on the human torso, and thus it was possible to measure the respiratory rate. Furthermore, we show that such a wearable system enables to keep track of the way of breathing (diaphragmatic, upper costal and mixed when the sensor is placed at different positions of the torso. A comparison of the results with the output of some commercial respiratory measurements devices confirmed the utility of such a monitoring device.

  20. Liquid crystal based sensors monitoring lipase activity: a new rapid and sensitive method for cytotoxicity assays.

    Science.gov (United States)

    Hussain, Zakir; Zafiu, Christian; Küpcü, Seta; Pivetta, Lucineia; Hollfelder, Nadine; Masutani, Akira; Kilickiran, Pinar; Sinner, Eva-Kathrin

    2014-06-15

    In this work we present liquid crystal (LC) based sensor devices to monitor cell viability. The sensing layer is composed by the LC and a planar monolayer of phospholipids. In the presence of minute traces of phospholipases, which hydrolyze enzymatically phospholipids, the LC-lipid interface is disintegrated. This event causes a change in orientation of the LC, which was followed in a polarized microscope. The lipase activity can be used to measure the cell viability, since members of this enzyme family are released by cells, as they undergo necrosis. The described sensor was used to monitor the presence of the lipases released from three different cell lines, which were either exposed to highly cytotoxic model compounds (sodium azide and paracetamol) or subjected to freeze-thaw cycles to induce cell death by a non-chemical based inducer for apoptosis, such as temperature. Finally, the comparison of lipase activity detected by a state-of-the-art fluorescence assay to the LC based system resulted in the superiority of the LC system concerning incubation time and sensitivity.

  1. Thin gas cell with GRIN fiber lens for intra-cavity fiber laser gas sensors

    Science.gov (United States)

    Li, Mo; Dai, Jing-min; Peng, Gang-ding

    2009-07-01

    Fiber laser gas sensors based on the intra-cavity absorption spectroscopy require the use of gas cells. We propose a simple and reliable gas cell using graded-index fiber lens (GFL) based all-fiber collimator. Conventional gas cells usually utilize direct fiber-to-fiber coupling without collimators or graded-index (GRIN) lens as collimators. Direct fiberto- fiber gas cell has simple configuration, but it suffers from high coupling loss and stray light interference. Gas cells applying fiber pigtailed GRIN lens are advantageous to achieve low coupling loss. However, fiber pigtailed GRIN lens requires accurate and complicated alignment and glue packaging which could compromise long term reliability and thermal stability. The proposed technique fabricates all-fiber collimators by simply splicing a short section of gradedindex fiber to single mode fiber which is both compact and durable. With that collimator, the gas cell can be fabricated very thin and are suitable for extreme environments with high temperature and vibration. In this paper, we have carried out experiment and analysis to evaluate the proposed technique. The coupling efficiency is studied versus different GFL gradient parameter profiles using ray matrix transformation of the complex beam parameter. Experiments are also done to prove the practical feasibility of the collimator. The analysis indicates that gas cell using GFLs can overcome the disadvantages of traditional design; it may replace the conventional gas cells in practical applications.

  2. Relative Distance Based Routing for Delay Tolerant Mobile Sensor Network

    Directory of Open Access Journals (Sweden)

    Jieyan Liu

    2011-08-01

    Full Text Available Delay Tolerant Mobile Sensor Network (DTMSN is the network for pervasive information gathering. Traditional static routing approaches may not fit for DTMSN due to its intermittent connectivity. This paper proposes an relative distance based routing (RDBR strategy for DTMSN, in which nodes delivery probabilities are calculated and updated according to the latest relative distance from themselves to the sink node, and data are delivered according to nodes’ delivery probabilities. RDBR also introduces a redundant copies controlling technique based on the message priority. Simulation results show that RDBR achieves a well tradeoff between the data delivery ratio/delay and the delivery overhead.

  3. Silicon nanowire based Pirani sensor for vacuum measurements

    Science.gov (United States)

    Brun, T.; Mercier, D.; Koumela, A.; Marcoux, C.; Duraffourg, L.

    2012-10-01

    Nano-Pirani vacuum gauges based on the physical properties of suspended silicon nanowires have been fabricated and characterized. With a 160 × 260 nm2 rectangular section and a 5.2 μm length, they are 50 times smaller than the smallest silicon based vacuum sensor and they exhibits much lower power consumption. The nano-Pirani constructed are capable of measuring pressures from 50 to 105 Pa. Moreover, their fabrication is compatible with microelectronic and micromachining fabrication techniques making them suitable for in-situ monitoring of micro and nano systems vacuum packaging.

  4. Hemagglutination detection for blood typing based on waveguide-mode sensors

    Directory of Open Access Journals (Sweden)

    Hiroki Ashiba

    2015-03-01

    Full Text Available ABO and Rh(D blood typing is one of the most important tests performed prior to blood transfusion. Although on-site blood testing is desirable for expedient blood transfusion procedure, most conventional methods and instruments lack the required usability or portability. Here, we describe a novel method, based on the detection of hemagglutination using an optical waveguide-mode sensor, for on-site use. The reflectance spectrum of blood alone and that of blood mixed with antibody reagents was measured using the waveguide-mode sensor. Differences in reflectance by agglutinated and non-agglutinated blood samples were observed at the bottom of the spectral dips; due to differences in the manner in which red blood cells interacted with the surface of the sensor chip. Following the addition of the antibody, blood types A, B, O, and AB were clearly distinguishable and Rh(D typing was also possible using the waveguide-mode sensor. Furthermore, the waveguide-mode-based measurement exhibited the potential to detect weak agglutination, which is difficult for human eyes to distinguish. Thus, this method holds great promise for application in novel on-site test instruments.

  5. Yeast cell wall integrity sensors form specific plasma membrane microdomains important for signalling.

    Science.gov (United States)

    Kock, Christian; Arlt, Henning; Ungermann, Christian; Heinisch, Jürgen J

    2016-09-01

    The cell wall integrity (CWI) pathway of the yeast Saccharomyces cerevisiae relies on the detection of cell surface stress by five sensors (Wsc1, Wsc2, Wsc3, Mid2, Mtl1). Each sensor contains a single transmembrane domain and a highly mannosylated extracellular region, and probably detects mechanical stress in the cell wall or the plasma membrane. We here studied the distribution of the five sensors at the cell surface by using fluorescently tagged variants in conjunction with marker proteins for established membrane compartments. We find that each of the sensors occupies a specific microdomain at the plasma membrane. The novel punctate 'membrane compartment occupied by Wsc1' (MCW) shows moderate overlap with other Wsc-type sensors, but not with those of the Mid-type sensors or other established plasma membrane domains. We further observed that sensor density and formation of the MCW compartment depends on the cysteine-rich head group near the N-terminus of Wsc1. Yet, signalling capacity depends more on the sensor density in the plasma membrane than on clustering within its microcompartment. We propose that the MCW microcompartment provides a quality control mechanism for retaining functional sensors at the plasma membrane to prevent them from endocytosis.

  6. Sensors on speaking terms : schedule-based medium access control protocols for wireless sensor networks

    NARCIS (Netherlands)

    Hoesel, van Lodewijk Frans Willem

    2007-01-01

    Wireless sensor networks make the previously unobservable, observable. The basic idea behind these networks is straightforward: all wires are cut in traditional sensing systems and the sensors are equipped with batteries and radio’s to virtually restore the cut wires. The resulting sensors can be pl

  7. Current-Induced Transistor Sensorics with Electrogenic Cells.

    Science.gov (United States)

    Fromherz, Peter

    2016-04-25

    The concepts of transistor recording of electroactive cells are considered, when the response is determined by a current-induced voltage in the electrolyte due to cellular activity. The relationship to traditional transistor recording, with an interface-induced response due to interactions with the open gate oxide, is addressed. For the geometry of a cell-substrate junction, the theory of a planar core-coat conductor is described with a one-compartment approximation. The fast electrical relaxation of the junction and the slow change of ion concentrations are pointed out. On that basis, various recording situations are considered and documented by experiments. For voltage-gated ion channels under voltage clamp, the effects of a changing extracellular ion concentration and the enhancement/depletion of ion conductances in the adherent membrane are addressed. Inhomogeneous ion conductances are crucial for transistor recording of neuronal action potentials. For a propagating action potential, the effects of an axon-substrate junction and the surrounding volume conductor are distinguished. Finally, a receptor-transistor-sensor is described, where the inhomogeneity of a ligand-activated ion conductance is achieved by diffusion of the agonist and inactivation of the conductance. Problems with regard to a development of reliable biosensors are mentioned.

  8. Conductive fiber-based ultrasensitive textile pressure sensor for wearable electronics.

    Science.gov (United States)

    Lee, Jaehong; Kwon, Hyukho; Seo, Jungmok; Shin, Sera; Koo, Ja Hoon; Pang, Changhyun; Son, Seungbae; Kim, Jae Hyung; Jang, Yong Hoon; Kim, Dae Eun; Lee, Taeyoon

    2015-04-17

    A flexible and sensitive textile-based pressure sensor is developed using highly conductive fibers coated with dielectric rubber materials. The pressure sensor exhibits superior sensitivity, very fast response time, and high stability, compared with previous textile-based pressure sensors. By using a weaving method, the pressure sensor can be applied to make smart gloves and clothes that can control machines wirelessly as human-machine interfaces.

  9. A Task Allocation Algorithm Based on Score Incentive Mechanism for Wireless Sensor Networks

    OpenAIRE

    Feng Wang; Guangjie Han; Jinfang Jiang; Wei Li; Lei Shu

    2015-01-01

    A wireless sensor network (WSN) consists of many resource constraint sensor nodes, which are always deployed in unattended environment. Therefore, the sensor nodes are vulnerable to failure and malicious attacks. The failed nodes have a heavily negative impact on WSNs’ real-time services. Therefore, we propose a task allocation algorithm based on score incentive mechanism (TASIM) for WSNs. In TASIM, the score is proposed to reward or punish sensor nodes’ task execution in cluster-based WSNs, ...

  10. P-bRS: A Physarum-Based Routing Scheme for Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mingchuan Zhang

    2014-01-01

    Full Text Available Routing in wireless sensor networks (WSNs is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH. Based on this model, we present a novel Physarum-based routing scheme (P-bRS for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms.

  11. Noninvasive blood pressure measurement scheme based on optical fiber sensor

    Science.gov (United States)

    Liu, Xianxuan; Yuan, Xueguang; Zhang, Yangan

    2016-10-01

    Optical fiber sensing has many advantages, such as volume small, light quality, low loss, strong in anti-jamming. Since the invention of the optical fiber sensing technology in 1977, optical fiber sensing technology has been applied in the military, national defense, aerospace, industrial, medical and other fields in recent years, and made a great contribution to parameter measurement in the environment under the limited condition .With the rapid development of computer, network system, the intelligent optical fiber sensing technology, the sensor technology, the combination of computer and communication technology , the detection, diagnosis and analysis can be automatically and efficiently completed. In this work, we proposed a noninvasive blood pressure detection and analysis scheme which uses optical fiber sensor. Optical fiber sensing system mainly includes the light source, optical fiber, optical detector, optical modulator, the signal processing module and so on. wavelength optical signals were led into the optical fiber sensor and the signals reflected by the human body surface were detected. By comparing actual testing data with the data got by traditional way to measure the blood pressure we can establish models for predicting the blood pressure and achieve noninvasive blood pressure measurement by using spectrum analysis technology. Blood pressure measurement method based on optical fiber sensing system is faster and more convenient than traditional way, and it can get accurate analysis results in a shorter period of time than before, so it can efficiently reduce the time cost and manpower cost.

  12. Optical-Based Artificial Palpation Sensors for Lesion Characterization

    Directory of Open Access Journals (Sweden)

    Hee-Jun Park

    2013-08-01

    Full Text Available Palpation techniques are widely used in medical procedures to detect the presence of lumps or tumors in the soft breast tissues. Since these procedures are very subjective and depend on the skills of the physician, it is imperative to perform detailed a scientific study in order to develop more efficient medical sensors to measure and generate palpation parameters. In this research, we propose an optical-based, artificial palpation sensor for lesion characterization. This has been developed using a multilayer polydimethylsiloxane optical waveguide. Light was generated at the critical angle to reflect totally within the flexible and transparent waveguide. When a waveguide was compressed by an external force, its contact area would deform and cause the light to scatter. The scattered light was captured by a high-resolution camera and saved as an image format. To test the performance of the proposed system, we used a realistic tissue phantom with embedded hard inclusions. The experimental results show that the proposed sensor can detect inclusions and provide the relative value of size, depth, and Young’s modulus of an inclusion.

  13. An information-based approach to decentralized multiplatform sensor management

    Science.gov (United States)

    Kreucher, Christopher M.; Kastella, Keith D.; Wegrzyn, John W.; Rickenbach, Brent L.

    2006-05-01

    This paper describes a decentralized low communication approach to multi-platform sensor management. The method is based on a physicomimetic relaxation to a joint information theoretic optimization, which inherits the benefits of information theoretic scheduling while maintaining tractability. The method uses only limited message passing, only neighboring nodes communicate, and each node makes its own sensor management decisions. We show by simulation that the method allows a network of sensor nodes to automatically self organize and perform a global task. In the model problem, a group of unmanned aerial vehicles (UAVs) hover above a ground surveillance region. An initially unknown number of moving ground targets inhabit the region. Each UAV is capable of making noisy measurements of the patch of ground directly below, which provide evidence as to the presence or absence of targets in that sub-region. The goal of the network is to determine the number of targets and their individual states (positions and velocities) in the entire surveillance region through repeated interrogation by the individual nodes. As the individual nodes can only see a small portion of the ground, they must move in a manner that is both responsive to measurements and coordinated with other nodes.

  14. A magnonic gas sensor based on magnetic nanoparticles.

    Science.gov (United States)

    Matatagui, D; Kolokoltsev, O V; Qureshi, N; Mejía-Uriarte, E V; Saniger, J M

    2015-06-07

    In this paper, we propose an innovative, simple and inexpensive gas sensor based on the variation in the magnetic properties of nanoparticles due to their interaction with gases. To measure the nanoparticle response a magnetostatic spin wave (MSW) tunable oscillator has been developed using an yttrium iron garnet (YIG) epitaxial thin film as a delay line (DL). The sensor has been prepared by coating a uniform layer of CuFe2O4 nanoparticles on the YIG film. The unperturbed frequency of the oscillator is determined by a bias magnetic field, which is applied parallel to the YIG film and perpendicularly to the wave propagation direction. In this device, the total bias magnetic field is the superposition of the field of a permanent magnet and the field associated with the layer of magnetic nanoparticles. The perturbation produced in the magnetic properties of the nanoparticle layer due to its interaction with gases induces a frequency shift in the oscillator, allowing the detection of low concentrations of gases. In order to demonstrate the ability of the sensor to detect gases, it has been tested with organic volatile compounds (VOCs) which have harmful effects on human health, such as dimethylformamide, isopropanol and ethanol, or the aromatic hydrocarbons like benzene, toluene and xylene more commonly known by its abbreviation (BTX). All of these were detected with high sensitivity, short response time, and good reproducibility.

  15. Recent developments in nanostructure based electrochemical glucose sensors.

    Science.gov (United States)

    Zaidi, Shabi Abbas; Shin, Jae Ho

    2016-01-01

    Diabetes is a major health problem causing 4 million deaths each year and 171 million people suffering worldwide. Although there is no cure for diabetes, nevertheless, the blood glucose level of diabetic patients should be monitored tightly to avoid further complications. Thus, monitoring of glucose in blood has become an inevitable need leading to fabrication of accurate and sensitive advanced blood sugar detection devices for clinical diagnosis and personal care. It led to the development of enzymatic glucose sensing approach. Later on, various types of nanostructures have been utilized owing to their high surface area, great stability, and cost effectiveness for the fabrication of enzymatic as well as for nonenzymatic glucose sensing approach. This work reviews on both categories, however it is not intended to discuss all the research reports published regarding nanostructure based enzymatic and nonenzymatic approaches between mid-2010 and mid-2015. We, do, however, focused to describe the details of many substantial articles explaining the design of sensors, and utilities of the prepared sensors, so that readers might get the principles behind such devices and relevant detection strategies. This work also focuses on biocompatibility and toxicity of nanomaterials as well as provides a critical opinion and discussions about misconceptions in glucose sensors.

  16. Optimal sensor placement using FRFs-based clustering method

    Science.gov (United States)

    Li, Shiqi; Zhang, Heng; Liu, Shiping; Zhang, Zhe

    2016-12-01

    The purpose of this work is to develop an optimal sensor placement method by selecting the most relevant degrees of freedom as actual measure position. Based on observation matrix of a structure's frequency response, two optimal criteria are used to avoid the information redundancy of the candidate degrees of freedom. By using principal component analysis, the frequency response matrix can be decomposed into principal directions and their corresponding singular. A relatively small number of principal directions will maintain a system's dominant response information. According to the dynamic similarity of each degree of freedom, the k-means clustering algorithm is designed to classify the degrees of freedom, and effective independence method deletes the sensors which are redundant of each cluster. Finally, two numerical examples and a modal test are included to demonstrate the efficient of the derived method. It is shown that the proposed method provides a way to extract sub-optimal sets and the selected sensors are well distributed on the whole structure.

  17. Zone Based Routing Protocol for Homogeneous Wireless Sensor Network

    Directory of Open Access Journals (Sweden)

    S. Taruna

    2011-09-01

    Full Text Available Wireless Sensor Networks, are made of low-cost, low -power, small in size, and multifunctional sensor nodes. The efficient energy utilization is one of t he important performance factors for wireless senso r networks survivability be-cause nodes operate with limited battery power. In this paper we propose and analyze a new approach of zone based clustering hea d selection algorithm for wireless sensor network o f homogeneous nodes. Nodes in the network are uniform ly distributed. In this clustering algorithm, netwo rk performance is improved by selecting cluster heads on the basis of the residual energy of existing clu ster heads, and nearest hop distance of the node. In thi s paper we evaluate various performance metrics lik e energy consumption, network life time, number of ch annel heads metrics in each round and compare these with respect to random algorithm i.e. LEACH. We con clude that proposed protocol effectively extends th e network lifetime without degrading the other critic al overheads and perform-ance metrics.

  18. Sphere-based calibration method for trinocular vision sensor

    Science.gov (United States)

    Lu, Rui; Shao, Mingwei

    2017-03-01

    A new method to calibrate a trinocular vision sensor is proposed and two main tasks are finished in this paper, i.e. to determine the transformation matrix between each two cameras and the trifocal tensor of the trinocular vision sensor. A flexible sphere target with several spherical circles is designed. As the isotropy of a sphere, trifocal tensor of the three cameras can be determined exactly from the feature on the sphere target. Then the fundamental matrix between each two cameras can be obtained. Easily, compatible rotation matrix and translation matrix can be deduced base on the singular value decomposition of the fundamental matrix. In our proposed calibration method, image points are not requested one-to-one correspondence. When image points locates in the same feature are obtained, the transformation matrix between each two cameras with the trifocal tensor of trinocular vision sensor can be determined. Experiment results show that the proposed calibration method can obtain precise results, including measurement and matching results. The root mean square error of distance is 0.026 mm with regard to the view field of about 200×200 mm and the feature matching of three images is strict. As a sphere projection is not concerned with its orientation, the calibration method is robust and with an easy operation. Moreover, our calibration method also provides a new approach to obtain the trifocal tensor.

  19. Organic electronics based pressure sensor towards intracranial pressure monitoring

    Science.gov (United States)

    Rai, Pratyush; Varadan, Vijay K.

    2010-04-01

    The intra-cranial space, which houses the brain, contains cerebrospinal fluid (CSF) that acts as a fluid suspension medium for the brain. The CSF is always in circulation, is secreted in the cranium and is drained out through ducts called epidural veins. The venous drainage system has inherent resistance to the flow. Pressure is developed inside the cranium, which is similar to a rigid compartment. Normally a pressure of 5-15 mm Hg, in excess of atmospheric pressure, is observed at different locations inside the cranium. Increase in Intra-Cranial Pressure (ICP) can be caused by change in CSF volume caused by cerebral tumors, meningitis, by edema of a head injury or diseases related to cerebral atrophy. Hence, efficient ways of monitoring ICP need to be developed. A sensor system and monitoring scheme has been discussed here. The system architecture consists of a membrane less piezoelectric pressure sensitive element, organic thin film transistor (OTFT) based signal transduction, and signal telemetry. The components were fabricated on flexible substrate and have been assembled using flip-chip packaging technology. Material science and fabrication processes, subjective to the device performance, have been discussed. Capability of the device in detecting pressure variation, within the ICP pressure range, is investigated and applicability of measurement scheme to medical conditions has been argued for. Also, applications of such a sensor-OTFT assembly for logic sensor switching and patient specific-secure monitoring system have been discussed.

  20. Oilwell Monitoring and Control based on Wireless Sensor Networks using ARM

    Directory of Open Access Journals (Sweden)

    V. Viknesh Velavan

    2012-09-01

    Full Text Available The existing oil-pumping unit (OPU system has a high power consuming process. It has the incapability of OPU’s structural health monitoring. A sensor network based intelligent control is proposed for power economy and efficient oilwell health monitoring using wireless sensor network. The proposed system consists of three-level sensors: First level sensors (FLS – designed with a temperature sensor, a voltage sensor, a current sensor, level sensor, gas sensor and a pressure sensor used for oilwell data sensing. Intelligent sensors (IS - designed mainly for an oilwell’s data elementary processing, main fault alarm indication, typical storage/indication, data/status transmission up to the third level sensor (TLS, data/status transmission between IS, and command transmission down to the OPU motor. Third level sensors (TLS - Software-defined (SD control centres with an embedded database. The TLS are designed for hundreds of oilwell’s data storage/management, data processing malfunction detection, malfunction alarm/indication; stroke-adjustment command transmission down to a specific IS for power economy and the malfunction report to the maintenance staff. Timer, Keyboard, A/D, communicationinterruptions are controlled by intelligent sensor. Delay aware data collection network structure is used for power economy and to reduce time delay in wireless sensor networks.

  1. Laser-based sensors on UAVs for quantifying local emissions of greenhouse gases

    Science.gov (United States)

    Zondlo, Mark; Tao, Lei; O'Brien, Anthony; Ross, Kevin; Khan, Amir; Pan, Da; Golston, Levi; Sun, Kang; DiGangi, Josh

    2015-04-01

    Small unmanned aerial systems (UAS) provide an ideal platform to sample both locally near an emission source as well as within the atmospheric boundary layer. However, small UAS (those with wingspans or rotors on the order of a meter) place severe constraints on sensor size (~ liter volume), mass (~ kg), and power (10s W). Laser-based sensors employing absorption techniques are ideally suited for such platforms due to their high sensitivity, high selectivity, and compact footprint. We have developed and flown compact sensors for water vapor, carbon dioxide and methane using new advances in open-path, laser-based spectroscopy on a variety of platforms ranging from remote control helicopters to long-duration UAS. Open-path spectroscopy allows for high frequency sampling (10-25 Hz) while avoiding the size/mass/power of sample delays, inlet lines, and pumps. To address the challenges of in-flight stability in changing environmental conditions and any associated flight artifacts on the measurement itself (e.g. vibrations), we use an in-line reference cell at a reduced pressure (10 hPa) to account for systematic drift continuously while in flight. Wavelength modulation spectroscopy is used at different harmonics to isolate the narrow linewidth of the in-line reference signal from the ambient, pressure-broadened absorption lineshape of the trace gas of interest. As a result, a metric of in-flight performance is achieved in real-time on the same optical pathlength as the ambient signal. To demonstrate the great potential of laser-based sensors on UAS, we deployed a 1.65 micron-based methane sensor (4 kg, 50 W, 100 ppbv precision at 10 Hz) on a UT-Dallas remote control aircraft for two weeks around gas/oil extraction activities as part of the EDF Barnett Coordinated Campaign in October 2013. We conducted thirty-four flights around a compressor station to examine the spatial and temporal characteristics of its emissions. Leaks of methane were typically lofted to altitudes

  2. Multi-Sensor Arrays for Online Monitoring of Cell Dynamics in in vitro Studies with Choroid Plexus Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Soledad García Gómez de las Heras

    2012-02-01

    Full Text Available Sensors and multi-sensor arrays are the basis of new technologies for the non-label monitoring of cell activity. In this paper we show that choroid plexus cells can be cultured on silicon chips and that sensors register in real time changes in their activity, constituting an interesting experimental paradigm for cell biology and medical research. To validate the signals recorded (metabolism = peri-cellular acidification, oxygen consumption = respiration; impedance = adhesion, cell shape and motility we performed experiments with compounds that act in a well-known way on cells, influencing these parameters. Our in vitro model demonstrates the advantages of multi-sensor arrays in assessment and experimental characterization of dynamic cellular events—in this case in choroid plexus functions, however with applicability to other cell types as well.

  3. Hiding the Source Based on Limited Flooding for Sensor Networks

    Directory of Open Access Journals (Sweden)

    Juan Chen

    2015-11-01

    Full Text Available Wireless sensor networks are widely used to monitor valuable objects such as rare animals or armies. Once an object is detected, the source, i.e., the sensor nearest to the object, generates and periodically sends a packet about the object to the base station. Since attackers can capture the object by localizing the source, many protocols have been proposed to protect source location. Instead of transmitting the packet to the base station directly, typical source location protection protocols first transmit packets randomly for a few hops to a phantom location, and then forward the packets to the base station. The problem with these protocols is that the generated phantom locations are usually not only near the true source but also close to each other. As a result, attackers can easily trace a route back to the source from the phantom locations. To address the above problem, we propose a new protocol for source location protection based on limited flooding, named SLP. Compared with existing protocols, SLP can generate phantom locations that are not only far away from the source, but also widely distributed. It improves source location security significantly with low communication cost. We further propose a protocol, namely SLP-E, to protect source location against more powerful attackers with wider fields of vision. The performance of our SLP and SLP-E are validated by both theoretical analysis and simulation results.

  4. Mobile Agent-Based Directed Diffusion in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Victor C. M. Leung

    2007-01-01

    Full Text Available In the environments where the source nodes are close to one another and generate a lot of sensory data traffic with redundancy, transmitting all sensory data by individual nodes not only wastes the scarce wireless bandwidth, but also consumes a lot of battery energy. Instead of each source node sending sensory data to its sink for aggregation (the so-called client/server computing, Qi et al. in 2003 proposed a mobile agent (MA-based distributed sensor network (MADSN for collaborative signal and information processing, which considerably reduces the sensory data traffic and query latency as well. However, MADSN is based on the assumption that the operation of mobile agent is only carried out within one hop in a clustering-based architecture. This paper considers MA in multihop environments and adopts directed diffusion (DD to dispatch MA. The gradient in DD gives a hint to efficiently forward the MA among target sensors. The mobile agent paradigm in combination with the DD framework is dubbed mobile agent-based directed diffusion (MADD. With appropriate parameters set, extensive simulation shows that MADD exhibits better performance than original DD (in the client/server paradigm in terms of packet delivery ratio, energy consumption, and end-to-end delivery latency.

  5. On Passive Wireless Sensors Based on Intermodulation Communication

    OpenAIRE

    Song, Jinsong

    2015-01-01

    Wireless sensors are needed in applications where a wired connection is difficult. Wireless sensors are often equipped with a radio transceiver and a battery or another energy source. These energy sources may limit life-time or operation conditions, and increase the size and cost of wireless sensors. Wireless sensors can also be passive. Due to the limited energy available for these sensors, they typically only support relatively short communication distances and may not provide a means fo...

  6. Sensor Fusion Based Model for Collision Free Mobile Robot Navigation

    OpenAIRE

    Marwah Almasri; Khaled Elleithy; Abrar Alajlan

    2015-01-01

    Autonomous mobile robots have become a very popular and interesting topic in the last decade. Each of them are equipped with various types of sensors such as GPS, camera, infrared and ultrasonic sensors. These sensors are used to observe the surrounding environment. However, these sensors sometimes fail and have inaccurate readings. Therefore, the integration of sensor fusion will help to solve this dilemma and enhance the overall performance. This paper presents a collision free mobile robot...

  7. Design and Implementation of a Laser-Based Ammonia Breath Sensor for Medical Applications

    KAUST Repository

    Owen, Kyle

    2012-06-01

    Laser-based sensors can be used as non-invasive monitoring tools to measure parts per billion (ppb) levels of trace gases. Ammonia sensors are useful for applications in environmental pollutant monitoring, atmospheric and combustion kinetic studies, and medical diagnostics. This sensor was specifically designed to measure ammonia in exhaled breath to be used as a medical diagnostic and monitoring tool, however, it can also be extended for use in other applications. Although ammonia is a naturally occurring species in exhaled breath, abnormally elevated levels can be an indication of adverse medical conditions. Laser-based breath diagnostics have many benefits since they are cost effective, non-invasive, painless, real time monitors. They have the potential to improve the quality of medical care by replacing currently used blood tests and providing immediate feedback to physicians. This sensor utilizes a Quantum Cascade Laser and Wavelength Modulation Spectroscopy with second harmonic normalized by first harmonic detection in a 76 m multi-pass absorption cell to measure ppb levels of ammonia with improved sensitivity over previous sensors. Initial measurements to determine the ammonia absorption line parameters were performed using direct absorption spectroscopy. This is the first experimental study of the ammonia absorption line transitions near 1103.46 cm1 with absorption spectroscopy. The linestrengths were measured with uncertainties less than 10%. The collisional broadening coefficients for each of the ammonia lines with nitrogen, oxygen, water vapor, and carbon dioxide were also measured, many of which had uncertainties less than 5%. The sensor was characterized to show a detectability limit of 10 ppb with an uncertainty of less than 5% at typical breath ammonia levels. Initial breath test results showed that some of the patients with chronic kidney disease had elevated ammonia levels while others had ammonia levels in the same range as expected for healthy

  8. Cell-based bioassays in microfluidic systems

    Science.gov (United States)

    Itle, Laura J.; Zguris, Jeanna C.; Pishko, Michael V.

    2004-12-01

    The development of cell-based bioassays for high throughput drug screening or the sensing of biotoxins is contingent on the development of whole cell sensors for specific changes in intracellular conditions and the integration of those systems into sample delivery devices. Here we show the feasibility of using a 5-(and-6)-carboxy SNARF-1, acetoxymethyl ester, acetate, a fluorescent dye capable of responding to changes in intracellular pH, as a detection method for the bacterial endotoxin, lipopolysaccharide. We used photolithography to entrap cells with this dye within poly(ethylene) glyocol diacrylate hydrogels in microfluidic channels. After 18 hours of exposure to lipopolysaccharide, we were able to see visible changes in the fluorescent pattern. This work shows the feasibility of using whole cell based biosensors within microfluidic networks to detect cellular changes in response to exogenous agents.

  9. Fault Detection and Recovery for Full Range of Hydrogen Sensor Based on Relevance Vector Machine

    Institute of Scientific and Technical Information of China (English)

    Kai Song; Bing Wang; Ming Diao; Hongquan Zhang; Zhenyu Zhang

    2015-01-01

    In order to improve the reliability of hydrogen sensor, a novel strategy for full range of hydrogen sensor fault detection and recovery is proposed in this paper. Three kinds of sensors are integrated to realize the measurement for full range of hydrogen concentration based on relevance vector machine ( RVM ) . Failure detection of hydrogen sensor is carried out by using the variance detection method. When a sensor fault is detected, the other fault⁃free sensors can recover the fault data in real⁃time by using RVM predictor accounting for the relevance of sensor data. Analysis, together with both simulated and experimental results, a full⁃range hydrogen detection and hydrogen sensor self⁃validating experiment is presented to demonstrate that the proposed strategy is superior at accuracy and runtime compared with the conventional methods. Results show that the proposed methodology provides a better solution to the full range of hydrogen detection and the reliability improvement of hydrogen sensor.

  10. Gas Sensors Based on Coated and Doped Carbon Nanotubes

    Science.gov (United States)

    Li, Jing; Meyyappan, Meyya

    2008-01-01

    Efforts are underway to develop inexpensive, low-power electronic sensors, based on single-walled carbon nanotubes (SWCNTs), for measuring part-per-million and part-per-billion of selected gases (small molecules) at room temperature. Chemically unmodified SWCNTs are mostly unresponsive to typical gases that one might wish to detect. However, the electrical resistances of SWCNTs can be made to vary with concentrations of gases of interest by coating or doping the SWCNTs with suitable materials. Accordingly, the basic idea of the present development efforts is to incorporate thus-treated SWCNTs into electronic devices that measure their electrical resistances.

  11. Regional Drought Monitoring Based on Multi-Sensor Remote Sensing

    Science.gov (United States)

    Rhee, Jinyoung; Im, Jungho; Park, Seonyoung

    2014-05-01

    Drought originates from the deficit of precipitation and impacts environment including agriculture and hydrological resources as it persists. The assessment and monitoring of drought has traditionally been performed using a variety of drought indices based on meteorological data, and recently the use of remote sensing data is gaining much attention due to its vast spatial coverage and cost-effectiveness. Drought information has been successfully derived from remotely sensed data related to some biophysical and meteorological variables and drought monitoring is advancing with the development of remote sensing-based indices such as the Vegetation Condition Index (VCI), Vegetation Health Index (VHI), and Normalized Difference Water Index (NDWI) to name a few. The Scaled Drought Condition Index (SDCI) has also been proposed to be used for humid regions proving the performance of multi-sensor data for agricultural drought monitoring. In this study, remote sensing-based hydro-meteorological variables related to drought including precipitation, temperature, evapotranspiration, and soil moisture were examined and the SDCI was improved by providing multiple blends of the multi-sensor indices for different types of drought. Multiple indices were examined together since the coupling and feedback between variables are intertwined and it is not appropriate to investigate only limited variables to monitor each type of drought. The purpose of this study is to verify the significance of each variable to monitor each type of drought and to examine the combination of multi-sensor indices for more accurate and timely drought monitoring. The weights for the blends of multiple indicators were obtained from the importance of variables calculated by non-linear optimization using a Machine Learning technique called Random Forest. The case study was performed in the Republic of Korea, which has four distinct seasons over the course of the year and contains complex topography with a variety

  12. ROBOT'S MOTION ERROR AND ONLINE COMPENSATION BASED ON FORCE SENSOR

    Institute of Scientific and Technical Information of China (English)

    GAN Fangjian; LIU Zhengshi; REN Chuansheng; ZHANG Ping

    2007-01-01

    Robot's dynamic motion error and on-line compensation based on multi-axis force sensor are dealt with. It is revealed that the reasons of the error are formed and the relations of the error are delivered. A motion equation of robot's termination with the error is established, and then, an error matrix and an error compensation matrix of the motion equation are also defined. An on-line error's compensation method is put forward to decrease the displacement error, which is a degree of millimeter, shown by the result of Simulation of PUMA562 robot.

  13. Location-based reliability differentiated service for wireless sensor networks

    Institute of Scientific and Technical Information of China (English)

    Yong ZENG; Jianfeng MA

    2009-01-01

    Designing reliability differentiated services for missions with different reliability requirements has become a hot topic in wireless sensor networks. Combined with a location-based routing mechanism, a quantified model without full network topology is proposed to evaluate reliability. By introducing a virtual reference point, the data transfer is limited in a specified area. The reliability function of the area is given. A detailed analysis shows that the function increases quadratically with the distance between the source node and the reference node. A reliability differentiated service mechanism is then proposed. The simulation results show the efficiency of the proposed mechanism.

  14. Analysis of a plastic optical fiber-based displacement sensor.

    Science.gov (United States)

    Jiménez, Felipe; Arrue, Jon; Aldabaldetreku, Gotzon; Durana, Gaizka; Zubia, Joseba; Ziemann, Olaf; Bunge, Christian-Alexander

    2007-09-01

    An easy-to-manufacture setup for a displacement sensor based on plastic optical fiber (POF) is analyzed, showing computational and experimental results. If the displacement is the consequence of force or pressure applied to the device, this can be used as a force or pressure transducer. Its principle of operation consists of bending a POF section around a flexible cylinder and measuring light attenuation when the whole set is subjected to side pressure. Attenuations are obtained computationally as a function of side deformation for different design parameters. Experimental results with an actually built prototype are also provided.

  15. Congestion Control Based on Reliable Transmission in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Hua Sun

    2014-03-01

    Full Text Available A new congestion control method is proposed in this paper. It makes use of the combination of buffer queue length and its variation rate to estimate the degree of congestion. It divides the node states and adopts various bandwidth allocation strategies according to different states, which ensures the reliable transmission of emergent information. Firstly, this paper introduces the queue model with priorities, divides the services according to different data flows and makes a detailed introduction on congestion adjustment mechanism based on the above information. The simulation experiment shows that the congestion control mechanism in this paper can ensure the reliable transmission of emergency information in monitoring sensor networks

  16. Study on gene sensor based on primer extension

    Institute of Scientific and Technical Information of China (English)

    陈誉华; 宋今丹; 李大为

    1997-01-01

    Based on the fact that the resonant frequency of a piezoelectric crystal is the function of its surface deposit, and that the primer extends after it hybridizes with the template, the primer extension gene sensor technique was developed. The prominent feature of the technique is that fast and sensitive frequency signals are used as the monitoring system of gene hybridization and primer strand extension. Results show that this technique may be used in homologous analysis of nucleic acid, trace DNA detection, and determining the integration of DNA. It may also be used for isolation of target gene, gene mutation analysis, and predicting the location of a gene in its genome.

  17. Silk-based conformal, adhesive, edible food sensors.

    Science.gov (United States)

    Tao, Hu; Brenckle, Mark A; Yang, Miaomiao; Zhang, Jingdi; Liu, Mengkun; Siebert, Sean M; Averitt, Richard D; Mannoor, Manu S; McAlpine, Michael C; Rogers, John A; Kaplan, David L; Omenetto, Fiorenzo G

    2012-02-21

    An array of passive metamaterial antennas fabricated on all protein-based silk substrates were conformally transferred and adhered to the surface of an apple. This process allows the opportunity for intimate contact of micro- and nanostructures that can probe, and accordingly monitor changes in, their surrounding environment. This provides in situ monitoring of food quality. It is to be noted that this type of sensor consists of all edible and biodegradable components, holding utility and potential relevance for healthcare and food/consumer products and markets.

  18. Car collision sensor based on a noise radar

    OpenAIRE

    2005-01-01

    This article presents the study of a car collision radar system. Previous research led to a mock-up working in the10GHz band, based on a pseudo-noise and a correlation process. This current study started from a marketed microwave sensor (Transmitter-Receiver Unit) connected to an interface I/O and a processing module. As a first step, and to define the system architecture, the module was simulated on a LabView platform. Different modulations were tested to evaluate the main limitations of the...

  19. Together we are strong--cell wall integrity sensors in yeasts.

    Science.gov (United States)

    Rodicio, Rosaura; Heinisch, Jürgen J

    2010-08-01

    The integrity of the fungal cell wall is ensured by a signal transduction pathway, the so-called CWI pathway, which has best been studied in the model yeast Saccharomyces cerevisiae. In this context, environmental stress and other perturbations at the cell surface are detected by a small set of plasma membrane-spanning sensors, viz. Wsc1, Wsc2, Wsc3, Mid2 and Mtl1. This review covers the recent advances in sensor structure, sensor mechanics, their cellular distribution and their in vivo functions, obtained from genetic, biochemical, cell biological and biophysical investigations.

  20. Advances in using MRI probes and sensors for in vivo cell tracking as applied to regenerative medicine

    Directory of Open Access Journals (Sweden)

    Amit K. Srivastava

    2015-04-01

    Full Text Available The field of molecular and cellular imaging allows molecules and cells to be visualized in vivo non-invasively. It has uses not only as a research tool but in clinical settings as well, for example in monitoring cell-based regenerative therapies, in which cells are transplanted to replace degenerating or damaged tissues, or to restore a physiological function. The success of such cell-based therapies depends on several critical issues, including the route and accuracy of cell transplantation, the fate of cells after transplantation, and the interaction of engrafted cells with the host microenvironment. To assess these issues, it is necessary to monitor transplanted cells non-invasively in real-time. Magnetic resonance imaging (MRI is a tool uniquely suited to this task, given its ability to image deep inside tissue with high temporal resolution and sensitivity. Extraordinary efforts have recently been made to improve cellular MRI as applied to regenerative medicine, by developing more advanced contrast agents for use as probes and sensors. These advances enable the non-invasive monitoring of cell fate and, more recently, that of the different cellular functions of living cells, such as their enzymatic activity and gene expression, as well as their time point of cell death. We present here a review of recent advancements in the development of these probes and sensors, and of their functioning, applications and limitations.