WorldWideScience

Sample records for cea

  1. The great Cea actors

    International Nuclear Information System (INIS)

    With the Claude Frejacques life it is a Cea passage that we find. He began the studies on uranium isotope separation. He developed and saw to a successful conclusion these researches at Cea during twenty five years and extended his sphere of operations to the whole fuel cycle, from upstream to downstream. Director of research at the Cea, he was also D.G.R.S.T. director and during eight years President of the C.N.R.S. (N.C.)

  2. CEA Annual report 2007

    International Nuclear Information System (INIS)

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities for the year 2007 in these three main areas: science and technology working for nuclear deterrence and global security, the energies without greenhouse effect gases emission against the climatic change, researches in the information sciences and technologies for a better communication and health. The CEA safety, organization, communication and international relations are also presented. (A.L.B.)

  3. CEA financial report 2007

    International Nuclear Information System (INIS)

    This document provides financial data on the CEA for the year 2007. The management report (budget, resources, expenditures) and the accounting are detailed. The main management events of the year 2007 are presented. (A.L.B.)

  4. CEA 2005 annual report

    International Nuclear Information System (INIS)

    This document is the 2005 activity report of the French atomic energy commission (CEA). The CEA is a main actor of nuclear research, development and innovation and is involved in three main domains: energy, defense/security, and information/health technologies thanks to high quality research works. With a manpower of 15000 researchers and collaborators with internationally acknowledged competences, the CEA is a driving force of industrial innovation and develops partnerships with French and European industries. It also warrants the perenniality of nuclear dissuasion. This report presents these different aspects of the CEA activities: 1 - defense-security: simulation program, opening to the scientific community, nuclear warheads, nuclear propulsion, cleansing of Rhone valley facilities, permanent monitoring of treaties respect, fight against terrorism; 2 - energy: optimization of the industrial park, advances in long lived radioactive wastes management, future nuclear systems, cleansing and dismantling integration, European nuclear energy research, new energy technologies; 3 - information and health technologies: major challenge of micro- and nano-technologies, key role of software technologies and complex systems; 4 - big research facilities opened to the scientific and industrial communities; 5 - scientific status: scientific evaluation process, prices and honors; 6 - programs support: revisited strategic control, confirmed simplification, active employment and training policy, teaching and training, technological valorization, international relations, communication, continuous quality approach, mastery of facilities safety, security, environmental control, a key-year for information systems. A financial report is attached to the document. (J.S.)

  5. CEA 2009 annual report

    International Nuclear Information System (INIS)

    After an indication of several key figures about the activity of the CEA (Centre d'Etudes Atomiques) and its relationship with the academic as well as the industrial field, in France and worldwide, this 2009 annual report presents its various research programs in the field of defence and of global security: basic research (nuclear weapons and propulsion, struggle against proliferation and terrorism) and applied research (nuclear deterrence, national and international security). Then, it presents the programs in the field of de-carbonated energy: basic research (in material science and in life sciences) and applied research (fission energy, fusion energy, new energy technologies). A last group of research programs deals with information and health technologies and concerns life and material sciences, micro- and nano-technologies, software technologies. Interaction with other research institutions and bodies is also evoked. A brief scientific assessment is proposed. Finally, the different structures building the CEA are presented

  6. CEA - Annual report 2006

    International Nuclear Information System (INIS)

    The CEA, a prominent player in research development and innovation, is active in 3 main areas: energy, health care and information technology and defense and security. This annual report presents the CEA activity for the year 2006 in these three main areas: Science and technology working for nuclear deterrence and global security (the simulation programs, the nuclear warheads, the nuclear propulsion, the decommissioning, the fighting against nuclear proliferation and monitoring international treaties, the global security); health and information technology (micro and nano technologies and systems); energy from nuclear fission and fusion and other technologies that do not emit greenhouse gases (progress for the nuclear industry, sustainable management of radioactive materials and waste, nuclear systems of the future, new energy technologies). (A.L.B.)

  7. CEA and mining industry

    International Nuclear Information System (INIS)

    The French atomic energy commission (CEA) is involved in the mining industry in several ways: - in the front-end of the nuclear industry through its daughter companies and participations in the exploration and exploitation of uranium ores, but also of gold and alloy metals with a 26% participation in Eramet company, the world leader of manganese and nickel. This activity is the main occupation of Cogema daughter company, via the Areva holding; - in the back-end of the nuclear fuel cycle with the delicate problem of the management of radioactive wastes; - in parallel with the nuclear industry through an important activity in semiconductor materials (FCI and SMTElectronics); - and finally through various research works on several mineral compounds. This article focusses on the fuel cycle aspects of the CEA activities and concludes with the research works carried out today on thermonuclear fusion. (J.S.)

  8. CEA sustainable development report 2007; CEA rapport developpement durable 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities in the domain of the sustainable development. The first part is devoted to the environment preservation policy (energy, water, air, chemistry, wastes, transport, buildings). The second part shows the dynamic governance in the domain of the risks management. The last part presents the CEA activities of research for the sustainable development. (A.L.B.)

  9. CEA Annual report 2007; CEA rapport annuel 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities for the year 2007 in these three main areas: science and technology working for nuclear deterrence and global security, the energies without greenhouse effect gases emission against the climatic change, researches in the information sciences and technologies for a better communication and health. The CEA safety, organization, communication and international relations are also presented. (A.L.B.)

  10. CEA financial report 2007; CEA rapport financier 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This document provides financial data on the CEA for the year 2007. The management report (budget, resources, expenditures) and the accounting are detailed. The main management events of the year 2007 are presented. (A.L.B.)

  11. CEA - 2014 risk management assessment

    International Nuclear Information System (INIS)

    After introducing presentations of CEA managers in charge of risk management and controls, this document presents and comments the actions undertaken by the CEA and the obtained results in terms of risk management in different fields: protection and control of the environment, installation safety, health, safety and radiation protection, transport of hazardous materials, waste management, protection of sites, installations and heritage, management of emergency situations, management of legal risks, internal audits and controls. Other topics are addressed like the presentation of the risk management department, and the role of the CEA in the relationship between research and industry

  12. CEA sustainable development report 2007

    International Nuclear Information System (INIS)

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities in the domain of the sustainable development. The first part is devoted to the environment preservation policy (energy, water, air, chemistry, wastes, transport, buildings). The second part shows the dynamic governance in the domain of the risks management. The last part presents the CEA activities of research for the sustainable development. (A.L.B.)

  13. Scientific evaluation at the CEA; Evaluation scientifique au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1998. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 5 parts dealing successively with: part 1 - the CEA, a public research organization (civil nuclear research, technology research and transfers, defence activities); the scientific and technical evaluation at the CEA (general framework, evaluation of the IPSN and DAM); part 2 - the scientific and technical councils (directions of fuel cycle, of nuclear reactors, and of advanced technologies); part 3 - the scientific councils (directions of matter and of life sciences); the nuclear protection and safety institute; the direction of military applications; part 4 - the corresponding members of the evaluation; part 5 - the list of scientific and technical councils and members. (J.S.)

  14. CEA Annual progress report 1986

    International Nuclear Information System (INIS)

    This annual report presents the general organization of the CEA, the international relations and politics in nuclear field, the activities (military application, nuclear applied research, ANDRA (National Agency for Radioactive Waste Management), nuclear safety and protection, fundamental research, applied research other than nuclear), the industrial group; among topics about men and means, the budget execution of the public establishment of research. In annex, the nuclear power plants around the world and the principal legislative texts related to CEA or atomic energy published in 1986

  15. CEA 2005 annual report; CEA rapport annuel 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This document is the 2005 activity report of the French atomic energy commission (CEA). The CEA is a main actor of nuclear research, development and innovation and is involved in three main domains: energy, defense/security, and information/health technologies thanks to high quality research works. With a manpower of 15000 researchers and collaborators with internationally acknowledged competences, the CEA is a driving force of industrial innovation and develops partnerships with French and European industries. It also warrants the perenniality of nuclear dissuasion. This report presents these different aspects of the CEA activities: 1 - defense-security: simulation program, opening to the scientific community, nuclear warheads, nuclear propulsion, cleansing of Rhone valley facilities, permanent monitoring of treaties respect, fight against terrorism; 2 - energy: optimization of the industrial park, advances in long lived radioactive wastes management, future nuclear systems, cleansing and dismantling integration, European nuclear energy research, new energy technologies; 3 - information and health technologies: major challenge of micro- and nano-technologies, key role of software technologies and complex systems; 4 - big research facilities opened to the scientific and industrial communities; 5 - scientific status: scientific evaluation process, prices and honors; 6 - programs support: revisited strategic control, confirmed simplification, active employment and training policy, teaching and training, technological valorization, international relations, communication, continuous quality approach, mastery of facilities safety, security, environmental control, a key-year for information systems. A financial report is attached to the document. (J.S.)

  16. INIS, CEA and nuclear terminology; INIS, CEA et terminologie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Surmont, J.; Brulet, C.; Constant, A.; Guille, N.; Le Blanc, A.; Mouffron, O.; Anguise, P.; Jouve, J.J

    2007-07-01

    This poster, prepared for the fifth edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents, first, the INIS information system, its content and coverage, the French participation to this system and the role of the CEA-Saclay as France's official representative for this system. Then it presents the INIS thesaurus with its different levels as a terminological tool for the indexing of documents and for searching documents inside the database. Finally, the very first electronic version of the multilingual thesaurus is introduced. Several national INIS centres, including the CEA-Saclay, have contributed to the translation of lists of new terms and of forbidden terms (synonyms). (J.S.)

  17. CEA - Annual report 2006; CEA - Rapport annuel 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The CEA, a prominent player in research development and innovation, is active in 3 main areas: energy, health care and information technology and defense and security. This annual report presents the CEA activity for the year 2006 in these three main areas: Science and technology working for nuclear deterrence and global security (the simulation programs, the nuclear warheads, the nuclear propulsion, the decommissioning, the fighting against nuclear proliferation and monitoring international treaties, the global security); health and information technology (micro and nano technologies and systems); energy from nuclear fission and fusion and other technologies that do not emit greenhouse gases (progress for the nuclear industry, sustainable management of radioactive materials and waste, nuclear systems of the future, new energy technologies). (A.L.B.)

  18. INIS, CEA and nuclear terminology

    International Nuclear Information System (INIS)

    This poster, prepared for the fifth edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents, first, the INIS information system, its content and coverage, the French participation to this system and the role of the CEA-Saclay as France's official representative for this system. Then it presents the INIS thesaurus with its different levels as a terminological tool for the indexing of documents and for searching documents inside the database. Finally, the very first electronic version of the multilingual thesaurus is introduced. Several national INIS centres, including the CEA-Saclay, have contributed to the translation of lists of new terms and of forbidden terms (synonyms). (J.S.)

  19. CEA: risk management assessment 2011

    International Nuclear Information System (INIS)

    This report proposes a qualitative and quantitative overview of CEA activities in the field of risk management during 2011. These activities concerned the impact on the environment, the safety of installations, the management of professional risks (safety and health at work), the radiological protection of workers, the transports of hazardous materials, waste management, protection of sites, installations and heritage, the management of emergency situations, the management of law risks, controls and audits

  20. CEA - Assessment of risk management 2013

    International Nuclear Information System (INIS)

    After some introducing texts by CEA managers, this report proposes a rather detailed overview and presentation of CEA activities, objectives and obtained results in different fields: protection and control of the environment, installation safety, health, safety and radiation protection, transports of hazardous materials, waste management, protection of sites, installations and heritage, management of emergency situations, management of legal risks, internal controls and audits, activity of the risk management department, CEA activities from research to industry

  1. Las Gramináceas

    Directory of Open Access Journals (Sweden)

    Robledo Emilio

    1939-08-01

    Full Text Available Las gramináceas son plantas conocidas desde la antigüedad más remota. Tan importantes son las gramináceas desde el punto de vista bromatológico, que los hombres pueden ser clasificados en comedores de trigo, de arroz, de maíz, de mijo, de sorgo, de tocusso, de tef, etc. El área de distribución de las gramíneas es inmensa: se las encuentra desde las orillas del mar y en las aguas dulces, hasta las nieves perpetuas; sólo en las aguas saladas desconocidas. En punto de tamaño, las hay desde unos centímetros hasta nuestra guadua gigantesca, de treinta y más metros de altura. Dicha distribución se halla en relación con el clima, pero también es influida por los hábitos de los pueblos, por la civilización, por el comercio o por otras circunstancias.

  2. Decontamination and dismantling at the CEA

    International Nuclear Information System (INIS)

    This document presents the dismantling policy at the CEA (French Research Center on the atomic energy), the financing of the decontamination and the dismantling, the regulatory framework, the knowledge and the technology developed at the CEA, the radiation protection, the environment monitoring and the installations. (A.L.B.)

  3. Memoirs of a Cea veteran

    International Nuclear Information System (INIS)

    A brief account is given of the way in which nuclear energy has developed in France and elsewhere over the last fifty years: options developed by the French Atomic Energy Commission (CEA), naval propulsion, development of pressurised water reactors, MOX and thorium fuels. Afterwards, the prospectives for the 21. century will be discussed. Considering that natural resources are depleting while releases of both greenhouse gases and world population are increasing, an active energy policy will have to be implemented with due consideration for social equity and solidarity. It is in this context that the developed countries will have to give preference, beyond savings, to renewable sources of energy, including of course, nuclear energy. Nuclear energy can continue to develop in the long term, provided fast breeder technology is developed at some point. As far as transport is concerned, hydrogen technology, which is clean and renewable, is promising, provided it is generated by nuclear energy. (author)

  4. CEA - 2012 Annual Report, 2012 Financial Statements

    International Nuclear Information System (INIS)

    In its first part, this report proposes an overview of activities within the CEA. They concern the CEA's programs on low on carbon energies and associated fundamental researches, on defence and global security and associated fundamental researches, on information technologies and associated fundamental researches, on health technologies and associated fundamental researches, and on very large research infrastructures and associated fundamental researches. The second part addresses the scientific assessment, activities related to teaching and training, to innovation towards enterprises, and to support to valorization. It also indicates prices awarded to the CEA. The third part addresses CEA management and institutional relationships, human resources, international relationships, activities related to communication and information diffusion, and risk management. The fourth part describes the CEA organization, its governance and its various bodies. The second volume contains the financial statements for 2012

  5. CEA - 2011 annual report, 2011 financial statement

    International Nuclear Information System (INIS)

    The first report, available both in French and English, presents the different current programs: low carbon energies and associated fundamental researches, global defence and safety and associated researches, information technologies and associated researches, technologies for health and associated fundamental researches, very large research infrastructures and associated fundamental researches. It then addresses the CEA openness: assessment, teaching and training, research valorisation, awards, and the support to various programs: steering activity by the CEA, human resources, international relationships, communication, risk management, information systems. The last part describes the CEA organisation. The second report presents the different financial and accounting data and tables

  6. CEA contribution to advanced robotics

    International Nuclear Information System (INIS)

    Due to development of nuclear energy in France, CEA has a long experience in nuclear robotics. It started from remote handling in hot cells and extended to inspections in nuclear reactors, intervention with vehicles, decommissioning of experimental plants, maintenance and intervention in reactors and reprocessing plants. Existing equipments, which are briefly described, show present status of performances for these applications. Research activities are going-on to develop this potential. Main aspects of recent advances in nuclear robotics are detailed to show that each application has some relevance with fusion remote handling needs. In this panel of activities, fusion would profit more directly from reprocessing and reactor maintenance studies, Computer Aided Teleoperation and advanced manipulators developments. But all the projects in nuclear and servicing robotics may have spin-offs for fusion and mention to Eureka projects will underline the necessity for European cooperation in this field. Finally, honor will be rendered to Jean Vertut who had from the first moment a real passion for fusion. (author). 3 refs, 4 figs, 2 tabs

  7. Clinical evaluation of radioassays for calcitonin, CEA-S, AFP and ferritin as tumor markers

    International Nuclear Information System (INIS)

    Clinical usefulness of the radioassays for serum calcitonin, isometric species of carcinoembryonic antigen (CEA-S), alpha-fetoprotein (AFP) and ferritin as the specific tumor markers was evaluated. The calcitonin assay was found to be extremely useful in detecting the cases of familial medullary carcinoma of the thyroid and in monitoring the patients after surgery. The CEA-S assay was proved more specific in titers and positivity for malignancies, especially GI tract carcinomas than CEA assay. The diagnosis of hepatoma could be performed precisely with a combination of 67Ga scintigraphy and assays of CEA and AFP. The serum ferritin levels in malignancies overlapped widely with those of non-malignancies. However, the estimation of ferritin-iron ratio was thought to be a useful means for screening patients with suspicious lesions. (author)

  8. CEA - Assessment of risk management for 2012

    International Nuclear Information System (INIS)

    This report proposes an overview of the main events, actions performed by the CEA, and facts for 2012 regarding protection and monitoring of the environment, installation safety, occupational health and safety, radiological protection of workers, transportation of hazardous materials, waste management, protection of sites, installations and heritage, emergency situation management, legal risk management, internal controls and audits. It also presents the organisation and action of the risk management department within the CEA

  9. The CEA-Industrie Group of Companies

    International Nuclear Information System (INIS)

    The 1988 financial and technological status of the CEA-Industry Group of Companies is summarized. The activities, technological innovations, and areas of development perspectives of the CEA-Industry Group of Companies, chiefly concentrated in fields relating to nuclear energy, are described. The principal business sectors of the group involve nuclear fuel cycle, nuclear plants and maintenance, computer applications and life science. Some activities of the group are extended to management, construction and financial fields

  10. 1999 scientific evaluation at the CEA

    International Nuclear Information System (INIS)

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1999. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 4 parts dealing successively with: 1)the CEA, a public research organization (strategy, research programs, new organization of the CEA activities, civil nuclear research, technology research and transfer, defence activities, transfer of knowledge) 2)the scientific evaluation at the CEA (evaluations of the civil applications of the CEA, IPSN, DAM, INSTN (national institute for nuclear sciences and techniques) 3)synthesis of the 1999 scientific and technical evaluation for each operational directions of the CEA (directions of fuel cycle, of nuclear reactors, of advanced technologies, of materials sciences, of life sciences, of military applications, of the nuclear protection and safety institute and of the national institute for nuclear sciences and techniques) 4)the corresponding members of the evaluation and the list of scientific and technical councils and members

  11. Decontamination and dismantling at the CEA; L'assainissement et le demantelement au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This document presents the dismantling policy at the CEA (French Research Center on the atomic energy), the financing of the decontamination and the dismantling, the regulatory framework, the knowledge and the technology developed at the CEA, the radiation protection, the environment monitoring and the installations. (A.L.B.)

  12. Presentation of CEA Marcoule laboratory department

    International Nuclear Information System (INIS)

    The CEA Marcoule Laboratory Department initially dedicated to production support, has recently been renovated to perform a wide range of analyses to support dismantling of plant operation and process development units. It provides services to the operators of the CEA Marcoule Research Center in the fields of analytical chemistry, metallographic examinations, radioactivity measurements, in situ or online nuclear measurements, decontamination processes and industrial chemistry studies. The facilities are designed to analyze all types of nuclear industrial and research samples both under inactive conditions and in glove box and hot cell environments. The Marcoule Laboratory today combines the skills of CEA researchers and AREVA NC analysts in support of production and R and D, process development and dismantling activities at Marcoule or other nuclear sites. (authors)

  13. Reagents for radioimmunological determination of carcinoembryonic antigen (CEA)

    International Nuclear Information System (INIS)

    The work was undertaken to prepare the reagents for carcinoembryonic antigen (CEA) radioimmunoassay with double antibody method. The CEA standard of high immunoreactivity was prepared and purified. The purified CEA was used for immunozation of goats. The goat anti - CEA sera were received. IgG fraction from normal goat serum was purified and used for the production of horse anti-goat IgG serum which was then used in the radioimmunoassay of CEA. The labelling of CEA with iodine-125 has been carried out be means of the enzymatic method.(Z.R.)

  14. Press tour Siloe CEA/GRENOBLE

    International Nuclear Information System (INIS)

    The experimental reactor, Siloe, has been stopped the 23 december 1997. This paper of the Cea Grenoble, presents the historical aspects of this reactor and its missions. It gives then a global description of the stopping and dismantling procedure, with the planning, the financing and the human impacts of the operation. The wastes management is also takes into account. (A.L.B.)

  15. 1999 scientific evaluation at the CEA; L'evaluation scientifique 1999 au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1999. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 4 parts dealing successively with: 1)the CEA, a public research organization (strategy, research programs, new organization of the CEA activities, civil nuclear research, technology research and transfer, defence activities, transfer of knowledge) 2)the scientific evaluation at the CEA (evaluations of the civil applications of the CEA, IPSN, DAM, INSTN (national institute for nuclear sciences and techniques) 3)synthesis of the 1999 scientific and technical evaluation for each operational directions of the CEA (directions of fuel cycle, of nuclear reactors, of advanced technologies, of materials sciences, of life sciences, of military applications, of the nuclear protection and safety institute and of the national institute for nuclear sciences and techniques) 4)the corresponding members of the evaluation and the list of scientific and technical councils and members.

  16. CEA: place and role in national science and industry

    International Nuclear Information System (INIS)

    The data on the main trends in CEA activity are given. The role, which CEA plays in French scientific and engineering spheres, is estimated. Examples of CEA international links are discussed, and its contribution into the World scientific and technical progress is shown

  17. Observation on CEA and IL-6 contents in gastric juice

    International Nuclear Information System (INIS)

    Objective: To study the changes of CEA and IL-6 contents in blood and gastric juice in patients with gastric cancer and gastritis. Methods: CEA and IL-6 contents in blood and gastric juice were measured with RIA in 60 patients and 30 controls. Results: Gastric juice CEA and IL-6 contents in patients with gastric carcinoma were significantly higher than those in the controls (p < 0.001), however, CEA and IL-6 contents in patients with gastritis and controls were not much different. Conclusion: Gastric juice CEA and IL-6 assay is of diagnostic significance in patients with gastric malignant tumor

  18. CEA/Valduc Plutonium Recycling Facility Project

    International Nuclear Information System (INIS)

    Pu recycling activities are operated in the 118 facility on Valduc CEA/DAM center. This facility, built in 1963, does not meet modern safety requirements especially for fire and earthquake hazards. The last safety review commission in 2000 gave the authorization to continue recycling operations in the 118 facility until the end of 2010 with the obligation of the achievement, of a safety upgrade program in 2005. At the same time, CEA/DAM has decided to launch the project for the building of a new facility for Pu recycling and legacy residues stabilization. In addition to specific requirements for Pu metal preparation, the processes retained for this facility have to optimize safety, wastes, costs and dosimetry. Moreover, all wastes have to be suitable for discard or of for a safe long term storage in nuclear vault. First conceptual design elements and important basic safety requirements will be presented in this communication. (authors)

  19. The CEA contribution to quality control

    International Nuclear Information System (INIS)

    The Commissariat a l'Energie Atomique has developed original methods and techniques for testing delicate components of the primary circuit of pressure water reactors. These techniques make use of a very wide range of non destructive testing methods: Eddy currents, particularly multiple frequencies, for testing steam generator tubes, gudgeon and other pins focused ultrasonics for testing all the welds of the reactor vessel and its cover plate, mixed welds of steam vessels and generators, low welds of the pressurizer and gudgeon pins from the inside. On site use is effected with specific machines intended either for inspecting the tube bundles of steam generators under the responsibility of INTERCONTROLE Co., or for the complete examination of the reactor vessel by mixed CEA/INTERCONTROLE crews under the responsibility of the CEA. All these operations are subjected to a programme of quality assurance that provides the guaranty of execution complying with the procedures in force

  20. When environment specialists meet the CEA

    International Nuclear Information System (INIS)

    The Afite, the French association of environment engineers and technicians, has organized in May 26 and 27, 1997 a visit of the Cadarache and Marcoule CEA's laboratories devoted to environmental research. The CEA (the French Atomic Energy Commission) and its associated companies represent about ten research centres in which original techniques are developed in order to solve some environmental problems related to nuclear and non-nuclear activities. This paper presents the main environmental research activities carried out at the Cadarache and Marcoule centres: climate evolution and global environment, seismic risks, industrial risks, plants/environment interactions (removal of pollutants, hydrocarbons and heavy metals from the soil), radioactive wastes characterization and processing, cycles of pollutants, nuclear fuels enrichment (SILVA process), remote handling techniques, spent fuels reprocessing, confinement of nuclear wastes and dismantling of nuclear installations. (J.S.)

  1. Ecotoxicological monitoring at CEA - Centro Experimental Aramar

    International Nuclear Information System (INIS)

    The environmental preservation has been one of the major targets of the Centro Experimental Aramar (CEA), since its foundation. The research center is located near Ipero, SP, and is maintained by Centro Tecnologico da Marinha em Sao Paulo - CTMSP. An Environmental Monitoring Program is developed with many types of matrices being periodically collected and analysed, including all the gaseous and liquids emissions liberated by the facilities. Besides radiometric and chemical analysis we have been testing bioassays for the effluents to accomplish the new recommendations from governmental agencies. The microcrustacean Daphnia similis has been tested in toxicity assays on liquid effluents and the garden plant Tradescantia pallida has been used to assess the genotoxicity effects from gaseous emissions. The results show that liquid and gaseous emissions from CEA are bellow the regulatory levels. (author)

  2. CEA: assessment of risk management 2011

    International Nuclear Information System (INIS)

    This report proposes an overview of CEA activities in the field of risk management in different areas: impact on the environment, installation safety, management of occupational risks (occupational health and safety), radiological protection of workers, transportation of hazardous materials, waste management, protection of sites, installations and heritage, management of emergency situations, management of law risks, controls and audits. It finally presents the risk management department

  3. Structural Integrity Analysis of CEA Change Platform

    International Nuclear Information System (INIS)

    The Control Element Assembly Change Platform (CEA CP) is similar to a gantry crane. The CEA CP for Shin-Kori units 3 and 4 (SKN 3 and 4) consists of a bridge, which spans the reactor cavity pool and a gantry superstructure mounted on the bridge. The structure is approximately 8.8 m wide, 4.9 m long and 10.6 m high. The gantry superstructure supports one ton capacity hoist trolley and the bridge supports the In Core Instrumentation (ICI) retrieval cart which moves along the bridge. This paper presents the dynamic and structural analysis of CEA CP which is greater than that of the previous nuclear power plants to verify the structural integrity under the application of the earthquake spectrum. The analysis have been performed using the three orthogonal SSE response spectrum for SKN 3 and 4 which shows much higher acceleration value than OPR- 1000 Plants. In addition, the analyses are performed by 3-dimensional finite element analysis using ANSYS software

  4. Report transparency and nuclear safety 2007 CEA Grenoble; Rapport transparence et securite nucleaire 2007 CEA Grenoble

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Grenoble for the year 2007. Since 2002 the Passage project aims to realize the decontamination and the dismantling of old nuclear installations of the CEA Grenoble. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the year 2007 saw two main steps of the Passage project: the decommissioning of the Siloette reactor, a public consultation about the Lama laboratory dismantling. (A.L.B.)

  5. Carcinoembryonic antigen (CEA) level, CEA ratio, and treatment outcome of rectal cancer patients receiving pre-operative chemoradiation and surgery

    International Nuclear Information System (INIS)

    To investigate serum carcinoembryonic antigen (CEA) as a prognostic factor for rectal cancer patients receiving pre-operative chemoradiotherapy (CRT). Between 2000 and 2009, 138 patients with advanced rectal cancer receiving CRT before surgery at our hospital were retrospectively classified into 3 groups: pre-CRT CEA <6 ng/ml (group L; n = 87); pre-CRT CEA ≥ 6 ng/ml and post-CRT CEA <6 ng/ml (group H-L; n = 32); and both pre- and post-CRT CEA ≥ 6 ng/ml (group H-H; n = 19). CEA ratio (defined as post-CRT CEA divided by pre-CRT CEA), post-CRT CEA level and other factors were reviewed for prediction of pathologic complete response (pCR). Five-year disease-free survival (DFS) was better in groups L (69.0%) and H-L (74.5%) than in group H-H (44.9%) (p = 0.024). Pathologic complete response was observed in 19.5%, 21.9% and 5.3% of groups L, H-L and H-H respectively (p = 0.281). Multivariate analysis showed that ypN stage and pCR were independent prognostic factors for DFS and that post-CRT CEA level was independently predictive of pCR. As a whole, post-CRT CEA <2.61 ng/ml predicted pCR (sensitivity 76.0%; specificity 58.4%). For those with pre-CRT CEA ≥6 ng/ml, post-CRT CEA and CEA ratio both predicted pCR (sensitivity 87.5%, specificity 76.7%). In patients with pre-CRT serum CEA ≥6 ng/ml, those with “normalized” CEA levels after CRT may have similar DFS to those with “normal” (<6 ng/ml) pre-CRT values. Post-CRT CEA level is a predictor for pCR, especially in those with pre-CRT CEA ≥6 ng/ml

  6. Status of Cea spallation modules for ads

    International Nuclear Information System (INIS)

    In the framework of CEA studies on ADS dedicated to waste transmutation, a liquid metal reference concept and an alternative solid target have been evaluated to produce neutrons inside the spallation module. This work examines the design (neutronic, thermohydraulic and mechanical aspects) and the performances of both options. It is shown that a liquid Pb-Bi target offers more possibilities regarding to high protons current densities (possible industrial extrapolation) but that a solid target made with tungsten particles offers also interesting ability to create a neutrons flux appropriated (strong spectrum and flat axial distribution) to an sub-critical core dedicated to incineration. (author)

  7. Algunas orquidáceas americanas

    OpenAIRE

    Williams, Louis O.

    2012-01-01

    La presente contribución al conocimiento de las Orquidáceas americanas trata de algunas especies de México, América Central, Sur América y las Antillas. Estas notas son el resultado de determinaciones de varios ejemplares colectados en tales regiones, y que se hallan depositados en el Ames Herbarium, Cambridge, Mass., el United States National Museum, Washington, D. C., el New York Botanical Garden Herbarium, Nueva York, o en el Herbarium of the Missouri Botanical Garden, St.Louis, Missouri....

  8. Simplifying CEA through Excel, VBA, and Subeq

    Science.gov (United States)

    Foster, Ryan

    2004-01-01

    Many people use compound equilibrium programs for very different reasons, varying from refrigerators to light bulbs to rockets. A commonly used equilibrium program is CEA. CEA can take various inputs such as pressure, temperature, and volume along with numerous reactants and run them through equilibrium equations to obtain valuable output information, including products formed and their relative amounts. A little over a year ago, Bonnie McBride created the program subeq with the goal to simplify the calling of CEA. Subeq was also designed to be called by other programs, including Excel, through the use of Visual Basic for Applications (VBA). The largest advantage of using Excel is that it allows the user to input the information in a colorful and user-friendly environment while allowing VBA to run subeq, which is in the form of a FORTRAN DLL (Dynamic Link Library). Calling subeq in this form makes it much faster than if it were converted to VBA. Since subeq requires such large lists of reactant and product names, all of which can't be passed in as an array, subeq had to be changed to accept very long strings of reactants and products. To pass this string and adjust the transfer of input and output parameters, the subeq DLL had to be changed. One program that does this is Compaq Visual FORTRAN, which allows DLLs to be edited, debugged, and compiled. Compaq Visual FORTRAN uses FORTRAN 90/95, which has additional features to that of FORTRAN 77. My goals this summer include finishing up the excel spreadsheet of subeq, which I started last summer, and putting it on the Internet so that others can use it without having to download my spreadsheet. To finish up the spreadsheet I will need to work on debugging current options and problems. I will also work on making it as robust as possible, so that all errors that may arise will be clearly communicated to the user. New features will be added old ones will be changed as I receive comments from people using the spreadsheet

  9. Superconducting quadrupoles for LHC : CERN/CEA-CEN Saclay Collaboration

    CERN Multimedia

    CEA Saclay and CERN Collaboration

    1994-01-01

    Agreement has been signed between CERN and CEA Saclay, concerning the construction of two prototypes of the LHC latest quadrupoles. CEA Saclay was interested with the study, the design, the construction and the testing of this magnet. The fabrication took place at the CEN Laboratory at Saclay in Paris.

  10. Low carbon energies: action by the CEA

    International Nuclear Information System (INIS)

    In future decades we can expect the situation regarding energy and climate change to become more and more difficult. On one hand, population growth and essential development in emerging economies will increase the demand for energy; on the other, the depletion of fossil fuel reserves, procurement difficulties due to geopolitical tension, and global warming are all making the search for viable and competitive alternatives to hydrocarbons all the more urgent. In the 2007 edition of its World Energy Outlook report, the International Energy Agency (IEA) made the position clear. CEA is one of the major European research institutes working in the field of energy, he is part of European Energy Research Alliance (EERA). (authors)

  11. The Grenoble CEA Center: dismantled and rehabilitated

    International Nuclear Information System (INIS)

    The denuclearization program of the CEA center in Grenoble was launched in 2001. It involves 6 nuclear facilities (3 research reactors: Melusine, Siloette, and Siloe, and 1 laboratory (LAMA) and 2 units for processing wastes). The dismantling works were finished at the end of 2012 and the 2013 program concerns: the demolition of the buildings homing Melusine and Siloe reactors, the final rehabilitation of the Siloe raft, and the final rehabilitation of the laboratory and of the waste processing units. The budget is 117*106 euros for Siloe, 28*106 euros for Melusine, 6*106 euros for Siloette, 70*106 euros for the LAMA, and 90*106 euros for the 2 waste processing units. (A.C.)

  12. The complementary safety assessments of CEA's facilities

    International Nuclear Information System (INIS)

    The safety assessments of CEA's facilities was made in 2 steps. The first step that was performed end 2011 involved facilities that had priority according to the French Safety Authority among them the Jules Horowitz reactor being built in Cadarache, the Masurca reactor (being upgraded in Cadarache), the Plutonium workshop (being dismantled in Cadarache), the Osiris reactor (that operates in Saclay) and the Phenix reactor (decommissioned at Marcoule). The second step was performed in 2012. The main conclusion is the setting of a hard core of measures concerning equipment and organization that is able to sustain the vital functions of each facility in any accidental situation. Another consequence is the reinforcement of the emergency means (equipment and organization) in the Cadarache site. (A.C.)

  13. CEA programme on gas cooled reactors

    International Nuclear Information System (INIS)

    Future nuclear energy systems studies conducted by the CEA aim at investigating and developing promising technologies for future reactors, fuels and fuel cycles, for nuclear power to play a major part in sustainable energy policies. Reactors and fuel cycles are considered as integral parts of a nuclear system to be optimised as a whole. Major goals assigned to future nuclear energy systems are the following: reinforced economic competitiveness with other electricity generation means, with a special emphasis on reducing the investment cost; enhanced reliability and safety, through an improved management of reactor operation in normal and abnormal plant conditions; minimum production of long lived radioactive waste; resource saving through an effective and flexible use of the available resources of fissile and fertile materials; enhanced resistance to proliferation risks. The three latter goals are essential for the sustainability of nuclear energy in the long term. Additional considerations such as the potentialities for other applications than electricity generation (co-generation, production of hydrogen, sea water desalination) take on an increasing importance. Sustainability goals call for fast neutron spectra (to transmute nuclear waste and to breed fertile fuel) and for recycling actinides from the spent fuel (plutonium and minor actinides). New applications and economic competitiveness call for high temperature technologies (850 deg C), that afford high conversion efficiencies and hence less radioactive waste production and discharged heat. These orientations call for breakthroughs beyond light water reactors. Therefore, as a result of a screening review of candidate technologies, the CEA has selected an innovative concept of high temperature gas cooled reactor with a fast neutron spectrum, robust refractory fuel, direct conversion with a gas turbine, and integrated on-site fuel cycle as a promising system for a sustainable energy development. This objective

  14. Saclay CEA Centre. Environmental assessment 2009

    International Nuclear Information System (INIS)

    This report presents the environmental control organization (sampling places and frequencies) about the Saclay CEA centre, and indicates the authorized levels for liquid and gaseous effluent releases by its installations. It comments the obtained results concerning air quality, water quality (surface and underground waters), bio-indicators (sampling and measurements performed in grasses, fruits, vegetables, milk, and so on, with notably the presence of Tritium of K40), and the assessment of the radiological impact due to annual radioactive releases. The report discusses the evolution of Tritium releases since 1968, and gives an assessment of these releases before 1968 (i.e. before it has been systematically controlled). It comments the new regulation regarding releases and gives a comparison with the releases limits defined in 1978. A brief presentation of the Saclay center environmental policy is given

  15. CEA experimental feedback on sodium loop decommissioning

    International Nuclear Information System (INIS)

    The aim of this paper is to present experimental feedback on sodium loop dismantling techniques at the CEA (The French Atomic Energy Commission) and to offer recommendations for the decommissioning of Fast Reactor secondary sodium loops. This study is based on acquired CEA decommissioning experience which primarily concerns the following: the decommissioning of RAPSODIE (France's first Fast Reactor), the PHENIX reactor secondary loop replacement, the sodium loop decommissioning carried out by the Laboratory of Sodium Technologies and Treatment, and several technical documents. This paper deals with the main results of this survey. First, a comparison of 8 pipe-cutting techniques is made, taking into account speed in cutting, reliability, dissemination, fire risk due to the presence of sodium, cutting depth, and different types of waste (empty pipes, sodium-filled pipes, tanks...). This comparison has led us to recommend the use of an alternative saw or a chain saw rather than the use of the plasma torch or grinder. Different techniques are recommended depending on if they are on-site, initial cuttings or if they are to be carried out in a specially-designed facility referred to hereafter as 'the cutting building'. After the cutting stage, the sodium waste must be processed with water to become an ultimate stable waste. Four treatment processes are compared with different standards : speed, cost, low activity adaptability and 'large sodium quantity' adaptability. Recommendations are also made for reliable storage, and for the general dismantling system organization. Last, calculations are presented concerning a complete dismantling facility prototype capable of treating large amounts and volume of sodium wastes. (author)

  16. Ecotoxicological monitoring at CEA - Centro Experimental Aramar; Monitoramento ecotoxicologico no CEA - Centro Experimental Aramar

    Energy Technology Data Exchange (ETDEWEB)

    Mattiolo, Sandra Regina; Machado, Alessandra Carla Fattori Ergesse [Centro Tecnologico da Marinha em Sao Paulo (CTMSP), Sao Paulo, SP (Brazil)]. E-mail: sandra@ctmsp.mar.mil.br; alessan@ctmsp.mar.mil.br

    2005-07-01

    The environmental preservation has been one of the major targets of the Centro Experimental Aramar (CEA), since its foundation. The research center is located near Ipero, SP, and is maintained by Centro Tecnologico da Marinha em Sao Paulo - CTMSP. An Environmental Monitoring Program is developed with many types of matrices being periodically collected and analysed, including all the gaseous and liquids emissions liberated by the facilities. Besides radiometric and chemical analysis we have been testing bioassays for the effluents to accomplish the new recommendations from governmental agencies. The microcrustacean Daphnia similis has been tested in toxicity assays on liquid effluents and the garden plant Tradescantia pallida has been used to assess the genotoxicity effects from gaseous emissions. The results show that liquid and gaseous emissions from CEA are bellow the regulatory levels. (author)

  17. Carcinoembryonic antigen (CEA) as tumor marker in lung cancer

    DEFF Research Database (Denmark)

    Knudsen, Mie Grunnet; Sorensen, J B

    2012-01-01

    The use of CEA as a prognostic and predictive marker in patients with lung cancer is widely debated. The aim of this review was to evaluate the results from studies made on this subject. Using the search words "CEA", "tumor markers in lung cancer", "prognostic significance", "diagnostic...... significance" and "predictive significance", a search was carried out on PubMed. Exclusion criteria was articles never published in English, articles before 1981 and articles evaluating tumor markers in lung cancer not involving CEA. Initially 217 articles were found, and 34 were left after selecting those...... relevant for the present study. Four of these included both Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) patients, and 31 dealt solely with NSCLC patients. Regarding SCLC no studies showed that serum level of CEA was a prognostic marker for overall survival (OS). The use of CEA...

  18. Report transparency and nuclear safety 2007 CEA Saclay; Rapport transparence et securite nucleaire 2007 CEA Saclay

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Saclay for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially two public consultation on release authorizations and the Neurospin installations, the dismantling of the 49 nuclear installation, the shutdown of the learning reactor ULYSSE are detailed. (A.L.B.)

  19. Report transparency and nuclear safety 2007 CEA Marcoule; Rapport transparence et securite nucleaire 2007 CEA Marcoule

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Marcoule for the year 2007. Since its creation in 1955 the center realizes industrial and scientific activities relative to the civil and military applications of the radioactivity. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the following two base activities are detailed: Atalante and Phenix. (A.L.B.)

  20. Report transparency and nuclear safety 2007 CEA Cadarache; Rapport transparence et securite nucleaire 2007 CEA Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Cadarache for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the report discusses the beginning of the RJH reactor construction, the fourth generation reactors research programs, the implementing of la Rotonde the new radioactive wastes management installation, the renovation of the LECA. (A.L.B.)

  1. The organisation of criticality hazard prevention at the CEA

    International Nuclear Information System (INIS)

    This paper deals with the organisation of criticality hazard prevention at the French Atomic Energy Commission (CEA). This new organization has been experimented since the end of year 2000. During the first semester of year 2002, the CEA nuclear inspection team, who is in charge of the control function at the CEA general administration level, has performed an inquiry to check the effectiveness of the new organization. The conclusions of this inquiry are very positive; a few recommendations are now taken in to account to further improve the efficiency of this organization. (J.P.N.)

  2. CEA nuclear energy Directorate - Activity report 2012

    International Nuclear Information System (INIS)

    After an overview of the activities of the Directorate at the international level, of its scientific activities, and of the consideration given to quality, and a presentation of the transverse program on advanced materials, this report proposes presentations of activities in different domains: future nuclear industrial systems (reactors of 4. generation, back-end of the future cycle, sustainable management of nuclear materials, fundamental scientific and technological research), optimization of the present industrial nuclear activity (reactors of 2. and 3. generation, front-end and back-end of the fuel cycle), the main tools for nuclear development (numerical simulation, the Jules Horowitz reactor), valorisation, economic support of Haute-Marne and Meuse territories (the Syndiese project), nuclear dismantling and decontamination (dismantling projects, projects and works in Fontenay-aux-Roses, Grenoble and Saclay, waste and material flow management, nuclear service facilities, transports). It also presents the activities of some specific CEA centres like Marcoule (R and D in fuel cycle), Cadarache (future energies) and Saclay (nuclear sciences and simulation of reactors and fuel cycle)

  3. Carcinoembryonic antigen (CEA) dynamics in stomach cancer patients receiving cryotherapy

    International Nuclear Information System (INIS)

    Radioimmunologic assays of blood serum carcinoembryonic antigen (CEA) level were conducted at major stages of treatment of gastric cancer by subtotal stomach resection and gastrectomy with preliminary cryotreatment and thawing of tumor. A short-term rise in CEA level occurred in 53.9 % of cases 3-4 days after combined therapy. A decrease in CEA concentration at discharge from hospital as compared with preoperative level and that registered 3-4 days after operation was observed in 50 and 75 % of cases of combined therapy, respectively, and 47.5 and 37.5 % of controls (surgery without cryotreatment). There was nocorrelation between cryotreatment and changes in CEA level in gastric ulcer patients

  4. Balance 2003 of the risks control at the Cea

    International Nuclear Information System (INIS)

    As a research center on the energy, the information and health technologies and the defense, the Cea activities are indissociable from the risk control notion. To organize the risks management, the Cea decided to create in july 2003 a special pole of risks control and management. This presentation is based on some major topics of the risks control: the environmental impact control, the occupational risks control, the installations safety control and the hazardous matter transport control. (A.L.B.)

  5. Bivalent fragment of the ior-CEA1 antibody. A challenge to the positive CEA tumors radioimmunotherapy

    International Nuclear Information System (INIS)

    The directed radiotherapy of the solid tumors with fragments recombinants of radiolabelled antibodies is a topic of current investigation, so much at preclinical level as clinical. This work describes the preclinical characterization of a new fragment type diabody of the AcMo ior CEA1 that has been labelled with 131 I for their use in the diagnosis and the therapy of CEA positive tumors. The radiolabelling methodology used allows the incorporation of more than 90% of the radio iodine to the molecule without committing the capacity of recognition of its antigen significantly. The combination of the favourable properties pharmacy kinetic and high selective accumulation in the tumor, they make of the diabody anti CEA an appropriate candidate for the radioimmunodiagnosis and the radioimmunotherapy of tumors that expresses CEA (Author)

  6. Fusion technology. Annual report of the. Association Cea/EURATOM

    International Nuclear Information System (INIS)

    In 1996, the French EURATOM-CEA Association made significant contributions to the European technology programme. This work is compiled in this report as follows: the ITER CEA activities and related developments are described in the first section; blankets and material developments for DEMO, long term safety studies are summarised in the second part; the Underlying Technology activities are compiled in the third part of this report. In each section, the tasks are sorted out to respect the European presentation. For an easy reading, appendix 4 gives the list of tasks in alphabetical order with a page reference list. The CEA is in charge of the French Technology programme. Three specific organizational directions of the CEA, located on four sites (see appendix 5) are involves in this programme: Advanced Technologies Direction (DTA), for Material task; Nuclear Reactors Direction (DRN), for Blanket design, Neutronic problems, Safety tasks; Physical Sciences Direction (DSM) uses the competence of the Tore Supra team in the Magnet design and plasma Facing Component field. The CEA programme is completed by collaborations with Technicatome, COMEX-Nucleaire and Ecole Polytechnique. The breakdown of the programme by Directions is presented in figure 1. The allocation of tasks is given in appendix 2 and in appendix 3, the related publications. (author)

  7. 2nd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Mulder, Bob; Choukroun, Daniel; Kampen, Erik-Jan; Visser, Coen; Looye, Gertjan

    2013-01-01

    Following the successful 1st CEAS (Council of European Aerospace Societies) Specialist Conference on Guidance, Navigation and Control (CEAS EuroGNC) held in Munich, Germany in 2011, Delft University of Technology happily accepted the invitation of organizing the 2nd  CEAS EuroGNC in Delft, The Netherlands in 2013. The goal of the conference is to promote new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems using on-board sensing, computing and systems. A great push for new developments in GNC are the ever higher safety and sustainability requirements in aviation. Impressive progress was made in new research fields such as sensor and actuator fault detection and diagnosis, reconfigurable and fault tolerant flight control, online safe flight envelop prediction and protection, online global aerodynamic model identification, online global optimization and flight upset recovery. All of these challenges de...

  8. CEA's Implication in Nuclear Security Events Detection and Response

    International Nuclear Information System (INIS)

    In France, CEA1 is a key player in research, development and technical innovation in three main areas: energy, heath and information technologies, defence and global security. For example CEA has developed a multitude of technologies to fight nuclear, radiological, biological and chemical threats, as well as equipment to diagnose and assess radiological or nuclear improvised explosive devices. CEA is also involved in all technical aspects dealing with detection of and response to a nuclear security event. CEA is a major player in the operational response to a terrorist or criminal act involving Nuclear or Radiological material. He operates under DCI-IT2, a dedicated national structure which includes the necessary personnel to neutralize the threat. CEA is also in charge of advice and assist competent authorities in the management of a nuclear security event. The paper clarify CEA’s implication in detection of and response to a nuclear security event and position in the French organization for operational response, elements of the intervention strategy - research to neutralize the threat - as well as examples of technical achievements that most are made subject to transfer to an industrial. In the context of the common declaration from France-United Kingdom-United States of America governments at Seoul summit in March 2012 to engage to further strengthen worldwide preparedness to contend with the threat of nuclear terrorism, France has capability to response to a nuclear threat device. This document will support this declaration and will give examples of CEA involvement in Nuclear Security system and measures. (author)

  9. CEA 2011, a look back at a year of research

    International Nuclear Information System (INIS)

    For this year 2011, marked by the Fukushima accident, the goal is improved safety. This is a key issue being addressed by CEA, while at the same time boosting its R and D on low-carbon energies, defense and security, Health technologies, information technologies and very large research Infrastructures. With more than 650 priority patents filed in 2011, CEA maintains its position as the leading French research organization. CEA stands in 4. place among the European research organizations, in terms of the number of projects (535, including 70 that it coordinates) and financing obtained (nearly euros 55 M) under the European Commission's FP7 framework programme. CEA's civil programs are 30% funded from external revenues (partner companies, national incentive funds, local authorities and European Union), 49% from the Government and, finally, 21% from two funds dedicated to clean-up of civil and defense facilities. Of the euros 1, 391 M devoted to low-carbon energies, research into the new energy technologies and nuclear systems of the future each received a budget of euros 151 M in 2011. CEA plays a key role in the European Energy Research Alliance, as a founding member, a member of the executive committee and a member of the secretariat. It is France's representative. EERA has launched 13 joint programs, including 6 in 2011. It pools the research efforts of more than 150 institutes and universities, with more than 2, 000 staff employed full-time. CEA is present in 8 programs, with 100 full-time staff, in other words 5% of the total partner commitment. This special issue of 'Defis du CEA' journal deals with the main results of the researches carried out in 2011 at the CEA. Contents: 1 - Facts and figures 2011: Intellectual Property, European Financing, Budget, Nuclear Safety, European Research Programs, International Relations, International Collaboration, Spin-off, Scientific Excellence, Training; 2 - Low-carbon energies: Biofuels, Solar Photovoltaic, Nuclear, Energy

  10. Report transparency and nuclear safety 2007 CEA Grenoble

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Grenoble for the year 2007. Since 2002 the Passage project aims to realize the decontamination and the dismantling of old nuclear installations of the CEA Grenoble. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the year 2007 saw two main steps of the Passage project: the decommissioning of the Siloette reactor, a public consultation about the Lama laboratory dismantling. (A.L.B.)

  11. The CEA-industrie Group. Report for 1986

    International Nuclear Information System (INIS)

    From the end of 1983, the whole affiliates and participations of CEA are hept by CEA-industry. The group activity is principally in the nuclear field. Cogema and the whole fuel cycle, construction, maintenance, improvement of nuclear power plants, research reactors and naval propulsion boilers and the sector Power plants and nuclear services (Framatome, Technicatome, Intercontrole, Stmi, principally). A non-nuclear sector comes from new techniques or activities developed for the nuclear needs: computer science (CISI), biomedical field (ORIS-industrie), different activities such as ultrafiltration or robotics-productics

  12. Remote manipulators and mobile robots in the CEA

    International Nuclear Information System (INIS)

    Thanks to Jean Vertut's works in the seventies, the CEA has been a pioneer in nuclear remote manipulation and mobile robots conception and has developed innovating systems in response to industry request. During the nineties, improvements in computer control systems have led to the realization of functional demonstrators. In 1995, advances in technology have allowed to consider the first industrial applications of nuclear remote manipulators and robots. This paper gives a review of the development and research works carried out by the CEA in this domain since the seventies, and also some future prospects. (J.S.). 10 figs

  13. CEA Bolometer Arrays: the First Year in Space

    OpenAIRE

    Billot, Nicolas; Sauvage, M.; RODRIGUEZ, L.; Horeau, B.; Kiss, C.; Aussel, H.; Okumura, K; O. Boulade; Altieri, B.; Poglitsch, A.; Agnese, P.

    2010-01-01

    The CEA/LETI and CEA/SAp started the development of far-infrared filled bolometer arrays for space applications over a decade ago. The unique design of these detectors makes possible the assembling of large focal planes comprising thousands of bolometers running at 300 mK with very low power dissipation. Ten arrays of 16x16 pixels were thoroughly tested on the ground, and integrated in the Herschel/PACS instrument before launch in May 2009. These detectors have been successfully commissioned ...

  14. The opening of the CEA to the general public

    International Nuclear Information System (INIS)

    Full text: The relationships between science and society have evolved considerably over the past years, just like the perception of the nuclear industry in the French public opinion. Recent psychosociological surveys show that only half of the French population is familiar with the CEA and that the public would like to obtain new elements of judgment in order to be able to develop a direct appreciation of the activities of a research organization such as the Atomic Energy Commission. It is essential to meet the public's expectations, to keep it properly informed of the CEA's research activities, and to help it understand the relevance of the results obtained and the solutions offered to decision-makers, i.e. industrialists and public authorities. One way to answer the public opinion's questions and to meet its expectations is to allow a rowing number of visitors to see who we are, what we study in our laboratories, and how we work to contribute to scientific progress and to the diffusion of technology, in a manner that is useful to society as a whole. This describes the spirit and the objective that governed the very idea and elaboration of the program entitled 'Opening of the CEA to the general public'. This operation consists not only in having communication specialists guide visitors throughout the facilities and equipment of the CEA, but also in encouraging researchers and groups of visitors to meet in the laboratories. A 'CEA - communication' network is under construction. It already has nearly 600 members. Communication is considered to be a real calling that falls within the scope of the CEA's strategy, and the work accomplished in this respect is recognized to the same extent as research. To this end, a charter for the CEA - communication network will be signed by every contributor and manager. A training scheme focused on public speaking and scientific vulgarization was initiated. 50 members of the network have already been trained, and 250 will be in 1999

  15. How Packaging Fleet Renewal Fits French CEA Programs

    International Nuclear Information System (INIS)

    CEA's (French Atomic Energy Agency) packaging fleet is dedicated to transportation of test irradiated fuels, of research reactors fuels, of navy propulsion fuels, and of waste coming from and to nuclear plants or facilities. This fleet encompasses more than 30 types of casks ranging from 5 to 30 tons, with either recent designs or other dating back to the seventies. A study has been launched in order to perform a global analysis of the life expectancy of the existing CEA and COGEMA Logistics cask fleets with respect to a 2015 target, in order to anticipate its renewal, while limiting the number of type of cask. Key elements like periodical evolutions of design and transport regulations, lessons learnt of existing casks (design, approval and extensions, operational feedback, maintenance and dismantling) are taken into account in order to ensure compliance and availability of the fleet. Moreover, from design to cask delivery, including regulatory tests, safety analysis report/ CoC, and manufacturing, 3 to 5 years is needed. Therefore cask development should be taken into account earlier of invest and research's programs. The paper will address the current life expectancy study of CEA and COGEMA Logistics packaging fleet, based on lessons learnt and regulation evolution and on general R and D plans by user facilities. It will show how a comprehensive optimized fleet is made available to CEA and other customers. Such a fleet combines optimized investment and uses, thus entailing synergies for well-mastered costs of transports. (authors)

  16. Behaviour of heavy water in nuclear reactors of the CEA

    International Nuclear Information System (INIS)

    In the two heavy water reactors of the CEA: Zoe and P-2, we do: A) the supervision of the isotopic composition of the heavy water; B) the supervision of gases released by the decomposition of the heavy water under radiation, and to their recombination; C) periodic analyses of impurities. (M.B.)

  17. Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene

    International Nuclear Information System (INIS)

    Gastric carcinoma is one of the most frequent cancers worldwide. Patients with gastric cancer at an advanced disease stage have a poor prognosis, due to the limited efficacy of available therapies. Therefore, the development of new therapies, like immunotherapy for the treatment of gastric cancer is of utmost importance. Since the usability of existing preclinical models for the evaluation of immunotherapies for gastric adenocarcinomas is limited, the goal of the present study was to establish murine in vivo models which allow the stepwise improvement of immunotherapies for gastric cancer. Since no murine gastric adenocarcinoma cell lines are available we established four cell lines (424GC, mGC3, mGC5, mGC8) from spontaneously developing tumors of CEA424/SV40 T antigen (CEA424/Tag) mice and three cell lines derived from double-transgenic offsprings of CEA424/Tag mice mated with human carcinoembryonic antigen (CEA)-transgenic (CEA424/Tag-CEA) mice (mGC2CEA, mGC4CEA, mGC11CEA). CEA424/Tag is a transgenic C57BL/6 mouse strain harboring the Tag under the control of a -424/-8 bp CEA gene promoter which leads to the development of invasive adenocarcinoma in the glandular stomach. Tumor cell lines established from CEA424/Tag-CEA mice express the well defined tumor antigen CEA under the control of its natural regulatory elements. The epithelial origin of the tumor cells was proven by morphological criteria including the presence of mucin within the cells and the expression of the cell adhesion molecules EpCAM and CEACAM1. All cell lines consistently express the transgenes CEA and/or Tag and MHC class I molecules leading to their susceptibility to lysis by Tag-specific CTL in vitro. Despite the presentation of CTL-epitopes derived from the transgene products the tumor cell lines were tumorigenic when grafted into C57BL/6, CEA424/Tag or CEA424/Tag-CEA-transgenic hosts and no significant differences in tumor take and tumor growth were observed in the different hosts. Although

  18. CEA decommissioning strategy and program for nuclear facilities

    International Nuclear Information System (INIS)

    The CEA's experience of the decommissioning of nuclear facilities goes back many decades and relates to many installations of very different types. The first substantial operations began in the sixties and seventies, and included, for instance, the first plutonium plant at Fontenay-aux-Roses (total decommissioning) and a number of small research reactors and critical mock-ups such as Cesar and Peggy at Cadarache, and Minerve at Fontenay-aux-Roses. Some twenty facilities were dealt with by 2000, corresponding to around half of all the nuclear facilities permanently closed, beginning with the decommissioning of facility AT1 at La Hague, the pilot plant used by the CEA in the seventies for the reprocessing of spent fuel from fast neutron reactors in March 2001 and ending with the demolition of the G1 stack at Marcoule, on 19 July this year. During the nineties, decommissioning was scaled back and few of the operations in progress were completed. The end of the decade saw a slowdown which was a consequence of financial difficulties, as the CEA had not yet set aside sufficient funds to cover the work, even though, between 1993 and 1999, part of the necessary resources had been provided under an agreement with the industrial partners EDF and Cogema. At the present time, the situation is rapidly improving both as concerns organisational and financial issues for the CEA and as concerns the regulations and the management of waste for all the organisations involved. First of all, for the different problems associated with radioactive clean-up faced by its research centres, the efforts made by the CEA in the field of organisation and planning since the beginning of the nineties have led to the drawing up of an overall multi-year plan referred to as the 'CEA civil centre radioactive clean-up plan' and the appointment of the Legacy and Clean-up Directorate to act as the client and be in charge of application of the plan relating not only to decommissioning of the nuclear

  19. Inapplicability of CEA-7 as a canine bone marrow transplantation marker

    International Nuclear Information System (INIS)

    Procedures are described for histocompatibility matching, erythrocyte typing, and CEA-7 serum substance assay. Results of CEA-7 serum substance assays in CEA-7 positive recipients are shown by means of a graph. After lethal total body irradiation, the CEA-7 substance was demonstrable in the recipients' serum for only 7 to 10 days, with disappearance of the substance from the serum for an equivalent period of time and its reappearance thereafter

  20. The part of CEA as informations emitting organism towards the elected circle

    International Nuclear Information System (INIS)

    This document deals with the CEA (Commissariat a l'Energie Atomique) as an organisation emitting information towards politicians. The CEA is a public, scientific and industrial institution. Its main mission is to develop the mastery of the atom in the field of research, health, energy and defense. Lots of political bodies have some contacts with the CEA. A good communication between politicians and the CEA is therefore a must, as it is explained in this document. (TEC)

  1. Evaluation of the nuclear installations safety of the CEA in 1998; Le bilan de la surete des installations nucleaires du CEA en 1998

    Energy Technology Data Exchange (ETDEWEB)

    Laverie, M. [CEA, Dir. de la Surete Nucleaire et de la Qualite, 75 - Paris (France)

    1999-09-01

    Michel Laverie, Director of the nuclear safety and quality at the Cea, took stoke of the CEA nuclear installations in 1998. After a recall of the nuclear safety policy and organization, the author presents the risks factors bound to the CEA activities as the dismantling, the wastes and the human factors. A last part is devoted to the list of the accidents occurred during 1998 in the nuclear installations. Tables and statistics illustrate this analysis. (A.L.B.)

  2. Annual report of the Association EURATOM/Cea

    International Nuclear Information System (INIS)

    This annual report presents research activities, which have been performed in 2002 by the French EURATOM-Cea association in the frame of the European technology program. The first section describes EFDA (European fusion development agreement) activities and related developments carried out by the association. The second one is dedicated to the underlying technology program and finally the third one presents the inertial confinement fusion activities. In each section the tasks are sorted out according to the EFDA main fields: physics (heating and current drive, remote participation, diagnostics), vessel/in-vessel (vessel/blanket, plasma facing components, remote handling), magnet, tritium breeding and materials (water cooled lithium lead blanket, helium cooled pebble bed blanket, helium cooled lithium lead blanket, reduced activation ferritic martensitic steels, advanced materials, neutron source, fuel cycle), safety and environment, system studies (power plant conceptual studies, socio-economic studies) and JET technology activities. The EURATOM-Cea association is involved in all these studies

  3. 2011 reporting of the risk handling at CEA

    International Nuclear Information System (INIS)

    In 2011 CEA reported 100 events to the Authority for Nuclear Safety (ASN). 93 were graded 0 on the INES scale and 7 were graded 1. None of them had a significant impact on the staff health and the environment. 25% of these events concerned delays in the controls of safety equipment. In 2011 CEA had to manage several situations that led to a response of its crisis center: 1) the explosion of an oven belonging to the Socodei-Centraco company situated near the Marcoule Center, 2) the discovery of about 500 grenades from the first world war during digging out works in the Grenoble Center, 3) flooding due to heavy rains in the Cadarache Center, and 4) an intrusion attempt at the Cadarache Center. (A.C.)

  4. Overview of CEA research in the field of radionuclides migration

    International Nuclear Information System (INIS)

    This report presents a synthetic status of the researches conducted within the Nuclear Energy Division (CEA/DEN) in the field of radionuclides migration in three specific areas which have been chosen for their representativeness and potential impact: the migration of RN in PWR reactors, the migration of RN from a deep geological repository and the migration processes in the surface environments. In addition, some status is given about more generic research which is conducted in the field of RN speciation in the aqueous phase and at the interfaces and regarding chemistry / transport couplings. Additional information about the human and technical means involved in these fields of research in CEA/DEN is finally given in the Appendix. (authors)

  5. Physical protection of nuclear materials and facilities in CEA

    International Nuclear Information System (INIS)

    Full text: CEA (Commissariat a l'Energie Atomique), as nuclear operator, is responsible for the control and protection of their nuclear materials. Inside CEA, DCS (Central Security Division) is in charge of the security matters, DCS defines the CEA strategy in this field, especially in physical protection. The paper will present the physical protection strategy of CEA. DCS defines the rules and methods; the operators have to apply in order to fulfill the security objectives of CEA. CEA has to provide the regulatory authority with documents proving that it is in accordance with the requirements of the 25th July 1980 law and 12th May 1981 decree. It has to implement all the necessary means in order to achieve the results requested by the regulatory authority. All these arrangements are described in the 'license and control file'. This file should specify the facility safeguards and physical protection system. Accounting measures are also described. In this file, the petitioner has to justify its capacity for holding nuclear materials and for exercising authorized activities on them. So the organization and the installed means have to be described in this authorization file. For physical protection, containment, surveillance and physical protection measures are presented: Containment measures must prevent the unauthorized or unjustified movements of nuclear material in the framework of the authorized activities; Surveillance measures must guarantee the integrity of the containment, check that no material is exiting by an abnormal channel; Physical protection measures for the materials, the premises and the facilities are intended to protect them against malevolent actions by means of security systems. The Central Security Division has established guidelines to provide guidance to the nuclear materials holders in writing such files. Each holding unit has to establish a 'license and control file' and each CEA site establishes a 'site license and control file

  6. Physical protection of nuclear materials and facilities in CEA

    International Nuclear Information System (INIS)

    CEA (Commissariat a l'Energie Atomique), as nuclear operator, is responsible for the control and protection of their nuclear materials. Inside CEA, DCS (Central Security Division) is in charge of the security matters, DCS defines the CEA strategy in this field, especially in physical protection. The paper will present the physical protection strategy of CEA. DCS defines the rules and methods, the operators have to apply in order to fulfill the security objectives of CEA. CEA has to provide the regulatory authority with documents proving that it is in accordance with the requirements of the 25th July 1980 law and 12th May 1981 decree. It has to implement all the necessary means in order to achieve the results requested by the regulatory authority. All these arrangements are described in the 'license and control file'. This file should specify the facility safeguards and physical protection system. Accounting measures are also described. In this file, the petitioner has to justify its capacity for holding nuclear materials and for exercising authorized activities on them. So the organization and the installed means have to be described in this authorization file. For physical protection, containment, surveillance and physical protection measures are presented: Containment measures must prevent the unauthorized or unjustified movements of nuclear material in the framework of the authorized activities; Surveillance measures must guarantee the integrity of the containment, check that no material is exiting by an abnormal channel; Physical protection measures for the materials, the premises and the facilities are intended to protect them against malevolent actions by means of security systems. The Central Security Division has established guidelines to provide guidance to the nuclear materials holders in writing such files. Each holding unit has to establish a 'license and control file' and each CEA site establishes a 'site license and control file'. Guidelines have been

  7. Annual report of the Association EURATOM/Cea

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, Ph.; Le Vagueres, F

    2002-07-01

    This annual report presents research activities, which have been performed in 2002 by the French EURATOM-Cea association in the frame of the European technology program. The first section describes EFDA (European fusion development agreement) activities and related developments carried out by the association. The second one is dedicated to the underlying technology program and finally the third one presents the inertial confinement fusion activities. In each section the tasks are sorted out according to the EFDA main fields: physics (heating and current drive, remote participation, diagnostics), vessel/in-vessel (vessel/blanket, plasma facing components, remote handling), magnet, tritium breeding and materials (water cooled lithium lead blanket, helium cooled pebble bed blanket, helium cooled lithium lead blanket, reduced activation ferritic martensitic steels, advanced materials, neutron source, fuel cycle), safety and environment, system studies (power plant conceptual studies, socio-economic studies) and JET technology activities. The EURATOM-Cea association is involved in all these studies.

  8. 50. anniversary of the CEA. Anniversary Symposium papers

    International Nuclear Information System (INIS)

    This conference is composed of three tomes, and the titles of the various sessions are: fifty years of nuclear history; nuclear connection balance; uranium enrichment; nuclear wastes: past and present; nuclear fuel reprocessing; nuclear safety; research reactors at the CEA; birth of a scientific discipline, neutronics; fusion through magnetic confinement; large machines for the infinitesimal; laser, a marvelous tool; exploration of condensed matter; knowledge of the atomic nucleus; invariances and symmetries; nuclear astrophysics; polymers and interfaces; micro-electronics and micro-technologies; prospective with nano-technologies; metallurgy and materials; modelization and numerical simulation; electromagnetism and stealth; CEA, chemistry, health and environment; climate and environment, our past and future; the Earth from its formation to Man; life and nuclear tools; photosynthesis, how living beings use solar energy

  9. Application of VLLW management principles to the CEA research centers

    International Nuclear Information System (INIS)

    This document describes the content of a CEA policy relating to very low level waste management elaborated in application of the waste management principles defined in France. The policy deals with very low level waste, subject to recycling, incineration or landfill disposal. It does not deal with reuse. The following principles are applicable to waste streams produced by CEA nuclear installations either during operating or dismantling activities. The policy deals only with very low level wastes (VLLW) (order of magnitude: <100 Bq/g for high energy emitters). It does not deal with low, intermediate or high level waste, which are either recycled or incinerated in nuclear industry or disposed of in the Aube surface disposal (CSA) or kept in intermediate storage, before geological disposal or any alternative final solution

  10. The CEA and alternative energies. 8 April 2010 press conference

    International Nuclear Information System (INIS)

    This document presents the CEA's strategy in terms of alternative energies and the various implemented research programs which mainly concern the building sector and the transport sector. After a recall of the energy and climate context, a presentation of the NTE program (Nouvelles Technologies de l'Energie, new energy technologies), the different topics and projects are presented: photovoltaic solar energy and its integration in building; batteries, hydrogen and fuel cells for applications in transports; second-generation bio-fuels

  11. Facilities offered by the CEA group for training foreign specialists

    International Nuclear Information System (INIS)

    First set up in 1945, the CEA (French Atomic Energy Commission) opened its doors to foreign scientists and technicians as long ago as the 1950s, and particularly so since 1960. Among the 15 000 foreigners concerned, some have come in the capacity of co-workers, while others - approximately 10 000 - have taken courses for the purpose of receiving training. Since the CEA constitutes both a public scientific institution and an industrial group, especially by virtue of its branch organizations and specialized production units, it possesses incomparably varied facilities. This is why almost all the countries of the world, at some time or other, have had nationals at the Saclay, Fontenay-aux-Roses, Grenoble and Cadarache research centres, or the National Institute of Nuclear Science and Technology (INSTN) at Saclay, a specialized establishment set up in 1956, or else at the Razes Information and Further Training Centre (CIPRA), specializing in the uranium ore industry. Most of the trainees received over the last few years by the CEA Group stem from the developing countries, those coming to receive practical technological training being ever more numerous. Several of the training programmes devised have involved participation in industrial operations, either in conjunction with Technicatome, a branch organization specializing in nuclear engineering (Iran, Iraq) or in association with other CEA Group units (South Korea). The trainees usually receive fellowships through the intermediary of French diplomatic missions, in which case it is enough if they continue to receive the salary normally paid to them by the public organization employing them. On the other hand, technological training sometimes involves payment because of the expense involved (intensive supervision and expensive experimental work). Finally, courses in French are organized in France by specialized institutions, but English is acceptable for very brief training periods. (author)

  12. RELAP4/MOD-5-CEA pump coastdown experiment simulation

    International Nuclear Information System (INIS)

    Since is important the theoretical-experimental comparison to evaluate the computer codes, these paper presents the simulation with RELAP4/MOD5 Code of a loss of power energy in the pump of the ''Circuito Experimental de Agua-CEA''. From the results attained, the existing models in the Code showed to be very satisfatory quantitative and qualitative behavior of the attained experimental results. (author)

  13. Report transparency and nuclear safety 2007 CEA Cadarache

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Cadarache for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the report discusses the beginning of the RJH reactor construction, the fourth generation reactors research programs, the implementing of la Rotonde the new radioactive wastes management installation, the renovation of the LECA. (A.L.B.)

  14. Report transparency and nuclear safety 2007 CEA Marcoule

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Marcoule for the year 2007. Since its creation in 1955 the center realizes industrial and scientific activities relative to the civil and military applications of the radioactivity. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the following two base activities are detailed: Atalante and Phenix. (A.L.B.)

  15. Fire fight and security in CEA's research centers

    International Nuclear Information System (INIS)

    In each CEA's center a special unit called FLS (formation locale de securite) is in charge of the protection of staff and property. This unit is polyvalent and qualified for fire fight, first aid and guarding, its members are recruited mainly among the Paris fire brigade and the Marseilles' brigade of sea firemen. Their role is to prevent and detect any risk whatever this risk may be: chemical, electric or nuclear. (A.C.)

  16. Report transparency and nuclear safety 2007 CEA Saclay

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Saclay for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially two public consultation on release authorizations and the Neurospin installations, the dismantling of the 49 nuclear installation, the shutdown of the learning reactor ULYSSE are detailed. (A.L.B.)

  17. CEA's research programmes on future nuclear power systems

    International Nuclear Information System (INIS)

    The CEA (Commissariat a l'energie atomique et aux energies alternatives) is at the crossroads between sciences and technologies. In collaboration with corporate leaders and academics, it is working to improve the competitiveness of the existing fleet of nuclear facilities (PWR reactors and EPR) and to develop both a fourth generation of nuclear power reactors and technologies for processing spent fuel. Concerning the PWR reactors most of the work focuses on the extension of reactor operating life (till 60 years), a better use of uranium fuel in the reactor core, a better safety standard, a better reliability of fuel assemblies. This work is both theoretical and experimental with the possibility to use irradiation rigs at the OSIRIS reactor. Concerning the EPR most of the work is dedicated to sustain the commissioning and start of the first EPR in France on the Flamanville site. Concerning the fuel cycle, CEA's teams are working to improve every stage of the cycle from uranium extraction to the processing of spent fuels. In the nuclear industry, industrial cycles are very long so it is today's work to prepare the fourth generation of reactors even if the first reactor of the third generation is not yet in operation. CEA's research focuses on 2 types of fast reactors, one is sodium-cooled (with ASTRID prototype) while the other is gas-cooled (with ALLEGRO prototype). (A.C.)

  18. Lessons learned from CEA experience with dismantling project

    International Nuclear Information System (INIS)

    Since the late 1980s the CEA has been actively implementing methods to benefit from its experience in dismantling nuclear facilities. Capitalizing on prior experience - originally to address safety requirements - has now acquired greater importance in the CEA with the implementation of project management knowledge bases that require better control of performance and cost from initial estimates to completion. Changing regulations (waste, radiological protection, safety, etc.) and decommissioning policies in major organizations (objectives, funding, deadlines, organization, etc.) significantly influence dismantling projects. Experience with knowledge management has shown that the approach consisting in exhaustive project data collection often produces large, unwieldy information bases that are difficult to apply to subsequent projects. Principles and recommendations can nevertheless be derived, but require detailed analysis of all the aspects of dismantling (waste, dosimetry, conventional and nuclear safety, cost, deadlines, physical and radiological environment, regulatory provisions, etc.). The wide range of CEA facilities, the different stages in the course of a project that often lasts for several decades, changing operators and supervisors, all imply that a given situation can be assessed and reconsidered differently depending on the project organization, participants and background. Past results can be considered technically satisfactory, but poorly rated in terms of cost or scheduling. The current approach consists in focusing more on the relevance of the information conserved, favoring common practices emanating from a dedicated center of expertise, and applying suitable processes after discriminating between the lessons learned directly from experience and from consolidation of professional knowledge bases. (author)

  19. Overview on CEA Contributions to the Broader Approach Projects

    International Nuclear Information System (INIS)

    Full text: France is participating to the joint Europe-Japan so-called “Broader Approach Activities” in support of ITER and DEMO activities, consisting in 3 projects: The Engineering Design and Validation of a 14 MeV neutrons irradiation facility (IFMIF/EVEDA), the building of an International Fusion Research Center (IFERC) and the ITER Satellite Tokamak Programme (STP - JT-60SA). For IFMIF/EVEDA activities, CEA is in charge of the high intensity Injector, the first part of the Superconducting RF Linac, the Cryoplant, the Accelerator Control System, the delivery of specific Beam Diagnostics and RF power tubes. This activity covers the fabrication of the systems, test of most critical components, installation and commissioning at the Japanese site. For IFERC, in 2011, CEA contracted with Bull the procurement of the “Helios” computer which reached a performance of 1.5 Petaflop/s peak, making it, with its 70000 compute cores, the largest supercomputer dedicated to a single scientific community. It is complemented by large high bandwidth storage, pre/post processing, visualization systems and services for 5 years. The work started in Sept. 2007. In Jan. 2012, first users started to work. Helios was inaugurated in March 2012. For JT-60SA tokamak, CEA is responsible for providing the Cryoplant System (CS), 9 of the 18 Toroidal Field Coils and supporting structures, the TF Coils Test Facility (CTF) and cold tests, and 5 Magnet Power Supplies (MPS). CEA is also participating to the JT-60SA Research Plan update. TF coil activities started in 2007; a manufacturing contract was placed to Alstom in July 2011. The last coil will be delivered to Japan in late 2016. Prior shipment, coils will be tested in the CTF at CEA-Saclay. The CS was optimized to smooth the transient heat loads during plasma operation. For CS and MPS contract are expected to be placed in June and Dec. 2012 respectively. This paper gives an overview of present status of these projects since 2007

  20. Radioimmunoscintigraphy of non-small cell lung cancer using Tc-99m ANTI-CEA FAB` (immuRAID CEA)

    Energy Technology Data Exchange (ETDEWEB)

    Fig, L.M. [DVA Medical Center, Ann Arbor, MI (United States); Hughes, L.; Pinsky, C.M. [Immunomedics Inc., Morris Plains, NJ (United States)] [and others

    1994-05-01

    We conducted a Phase II prospective multicenter clinical trial to investigate the safety and efficacy of Tc-99M anti-CEA Fab`(ImmuRAID-CEA) in patients with non-small cell lung cancer. Fifty four patients (42 male; 12 female; age range 40-93 yr) had primary operable (19), primary inoperable (7), occult (9), metastatic (15) or recurrent (4) disease. Patients were injected with 1 mg ImmuRAID-CEA radiolabeled with 20-30 mCi Tc-99m pertechnetate and imaged at 4-8 and 18-24 hr by planar and SPECT techniques; ten were imaged at 15-18 hr only. Despite prominent blood pool activity at 4-8 hr. overall imaging statistics on a per patient basis revealed a sensitivity of tumor detection of 90%, accuracy 85% and positive predictive value 94%. The later images had lower count rates but target to background ratios were improved. On a per lesion basis, sensitivity in the chest was 69% and in liver 88%. Twenty four patients had additional foci of antibody uptake at sites previously believed to be uninvolved; cancer was confirmed in 11, not confirmed in 2 and currently indeterminate in 11. Furthermore, a negative scan confirmed equivocal radiographic studies as true negative in 5 patients. With respect to safety, there were no adverse clinical reactions and four minor, transient changes in hematologic and/or biochemical parameters. Human anti-mouse antibody (HAMA) determinations on 27 patients using ImmuSTRIP{reg_sign} HAMA Fragment assay were negative at 4-6 weeks or 3 months post-infusion. We conclude that imaging with ImmuRAID-CEA is safe and potentially useful for the evaluation and staging of lung cancer patients.

  1. Producing energy without greenhouse effect gases: the CEA action

    International Nuclear Information System (INIS)

    Major actor in the domain of new energy technologies, the CEA manages the french research on the hydrogen and the fuel cells. It is also implied with INES (National Institute for the Solar Energy) in the photovoltaic and thermal solar. With the IFP (French Petroleum Institute), it manages research on biofuels. Of course the thermonuclear fusion, for the development of the energy of the future, is in its research program too. This information document presents the possibilities of these energies and the associated research programs. (A.L.B.)

  2. Technical Aspect of Shielded SIMS Installation in CEA Cadarache

    International Nuclear Information System (INIS)

    A shielded IMS 6f has been installed in the LECA facility, CEA Cadarache France. The nuclearization was performed by CAMECA Company, which sells the standard IMS 6f. Working on nuclear materials requires in depth modifications of the apparatus itself. Despite these modifications, the shielded SIMS has the same level of performance as the standard apparatus. The design of the modified apparatus is presented and the safety aspects are emphasised. The shielded SIMS should be allowed to handle irradiated samples at the end of 2001. (Author)

  3. Sertula florae colombiae – xv: nuevas melastomatáceas

    OpenAIRE

    Uribe Uribe, Lorenzo

    2012-01-01

    El notable aumento de las colecciones del Herbario Nacional Colombiano muestran la riqueza de la flora melastomatácea de Colombia. Uno de los géneros más ricos y más bien caracterizados es Blakea. En este artículo describo dos nuevas especies muy interesantes. Dejo consignada mi gratitud para elnotable dibujante, don Silvio Fernández Valencia, a quien se deben las magníficas ilustraciones y muchos datos y mediciones de órganos pequeñísimos, que facilitaron  las descripciones exactas de las pl...

  4. The 1988 CEA progress report on laser research programs

    International Nuclear Information System (INIS)

    The 1988 CEA progress report, concerning laser investigations, is presented. The aim of the research programs on laser/matter interactions is to contribute to the military application works on this field, as well as to the development of the inertial confinement fusion physics. The activities related to the installation and starting of Phebus laser system are described. The development of soft x-ray instrumentation are included. In the field of numerical simulations, the improvement of FCI 1 and 2 codes are extended for increasing the field of the physical phenomena taken into account and getting their use more flexible to the experiment analysis

  5. Hookah smoking and cancer: carcinoembryonic antigen (CEA) levels in exclusive/ever hookah smokers

    OpenAIRE

    Chaouachi Kamal; Sajid Khan; Mahmood Rubaida

    2008-01-01

    Abstract Background We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere) and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (cigarettes, bidis, etc.). Objectives To find serum CEA levels in ever/exclusive hookah smokers, i.e. those who smoked only hookah (no cigarettes, bidis, etc.), prepared b...

  6. Evaluation of the nuclear installations safety of the CEA in 1998

    International Nuclear Information System (INIS)

    Michel Laverie, Director of the nuclear safety and quality at the Cea, took stoke of the CEA nuclear installations in 1998. After a recall of the nuclear safety policy and organization, the author presents the risks factors bound to the CEA activities as the dismantling, the wastes and the human factors. A last part is devoted to the list of the accidents occurred during 1998 in the nuclear installations. Tables and statistics illustrate this analysis. (A.L.B.)

  7. Preoperative serum levels of CEA and CA 242 in colorectal cancer.

    OpenAIRE

    Carpelan-Holmström, M; Haglund, C.; Kuusela, P.; Järvinen, H; Roberts, P. J.

    1995-01-01

    Preoperative serum levels of CEA and CA 242 were determined in 260 patients with colorectal cancer and in 92 patients with benign colorectal diseases. The overall sensitivity of the CEA test was 43% and of the CA 242 test 39%. The corresponding specificities were 90% and 87% respectively, using 5 ng ml-1 as cut-off level for CEA and 20 U ml-1 for CA 242. The sensitivity of CEA was 26%, 32%, 38% and 77% for Dukes A, B, C and D colorectal cancer, and the sensitivity of CA 242 was 26%, 26%, 40% ...

  8. Radioiodination of monoclonal antibody intact anti-CEA

    International Nuclear Information System (INIS)

    The purpose of this study is to examine a convenient system that can be used to iodinate monoclonal antibodies which is rapid, simple, efficient and reproducible, and which can be accomplished in radiopharmaceutical laboratories. It is important to remember that antibodies are sensitive biochemicals, subject to losses of the activity that is essential to their mode of action, namely the ability to bind specific antigen. The advent of solid phase iodination agents has greatly expanded the range of gentle iodination techniques available for iodinating sensitive biological materials. The agent most widely used is the Iodogen (1,3,4,6 tetrachloro-3a-6a diphenylglycoluril) method. Anti-CEA 4C sub(11) IgG sub(2a,k) (prepared in the Ludwig Institute-Sao Paulo-Brazil ) is used as model to evaluate the Iodogen methodology. The miniature chromatographic system, also rapid, accurate, simple, efficient was elaborated to determine the labelling efficiency incorporation of iodine into immunoglobulin, and the radiochemical purity of sup(131)I-anti-CEA. (author)

  9. CEA technical-economic activity report - Year 2014

    International Nuclear Information System (INIS)

    This report presents an assessment of activities undertaken by the CEA in the field of energy technique and economy during 2014. Technical-economic studies aims at contributing to national orientations on energy, at R and D program orientations, at highlighting and strengthening synergies between nuclear technologies and new energy technologies, and at strengthening the credibility of these technologies. After a presentation of the organisation of technique and economy within the CEA, of the involved bodies and departments, of the addressed themes (photovoltaic, wind, biomass and biofuels, hydrogen-based systems, mobility, electric systems and grids), the report presents studies performed in relationship with the national energy strategy and with energy scenarios, studies performed in the nuclear field (on fourth-generation reactors, on the front-end and back-end of the fuel cycle), studies performed in the field of new energy technologies and climate (hydrogen and storage, biofuels, climate, mobility, solar, electric systems). The next part addresses academic aspects, methodological studies and modelling studies. Contributions and participations to conferences, and publications are indicated

  10. 3rd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Drouin, Antoine; Roos, Clément

    2015-01-01

    The two first CEAS (Council of European Aerospace Societies) Specialist Conferences on Guidance, Navigation and Control (CEAS EuroGNC) were held in Munich, Germany in 2011 and in Delft, The Netherlands in 2013. ONERA The French Aerospace Lab, ISAE (Institut Supérieur de l’Aéronautique et de l’Espace) and ENAC (Ecole Nationale de l’Aviation Civile) accepted the challenge of jointly organizing the 3rd edition. The conference aims at promoting new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems. It represents a unique forum for communication and information exchange between specialists in the fields of GNC systems design and operation, including air traffic management. This book contains the forty best papers and gives an interesting snapshot of the latest advances over the following topics: l  Control theory, analysis, and design l  Novel navigation, estimation, and tracking methods l  Aircr...

  11. CEA contribution to power plant operation with high burnup level

    International Nuclear Information System (INIS)

    High level burnup in PWR leads to investigate again the choices carried out in the field of fuel management. French CEA has studied the economic importance of reshuffling technique, cycle length, discharge burnup, and non-operation period between two cycles. Power plants operators wish to work with increased length cycles of 18 months instead of 12. That leads to control problems because the core reactivity cannot be controlled with the only soluble boron: moderator temperature coefficient must be negative. With such cycles, it is necessary to use burnable poisons and for economic reasons with a low penalty in end of cycle. CEA has studied the use of Gd2O3 mixed with fuel or with inert element like Al2O3. Parametric studies of specific weights, efficacities relatively to the fuel burnup and the fuel enrichment have been carried out. Particular studies of 1 month cycles with Gd2O3 have shown the possibility to control power distribution with a very low reactivity penalty in EOC. In the same time, in the 100 MW PWR-CAP, control reactivity has been made with large use of gadolinia in parallel with soluble boron for the two first cycles

  12. Scientific evaluation at the French Atomic Energy Commission (CEA). 2005-2006 annual report; L'evaluation scientifique au CEA. Rapport annuel 2005-2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This report aims at presenting the scientific evaluation activities carried out at the CEA during the years 2005-2006. The evaluation system is described in detail. It comprises two aspects: the evaluation of the scientific policy implemented by the scientific Council and by the visiting committee of the CEA, and the evaluation of the laboratories, performed by a pool of 36 scientific councils. The evaluation by external and independent parties is the key point of this system. This document makes a status of the evaluations performed in 2005 and 2006. It presents a synthesis of the conclusions of the evaluation authorities. The actions implemented by the CEA to take into consideration the recommendations are also reported with the improvements noticed. The two topics examined by the scientific Committee and by the visiting committee were dealing with the energy domain, which is a strategic issue for the CEA. The examination of the researches on future nuclear reactors and on new energy technologies have shown the major role played by the CEA in the recent advances in these domains. About 95% of the laboratories activity was examined during the 2002-2005 period. The richness of the remarks and recommendations made by the scientific councils should allow the CEA to improve the quality and relevance of its research works. The start-up of the 2006-2009 evaluation cycle has been the occasion to modify the evaluation of some research domains in order to take into account the evolution of programs. The evaluation system of the CEA is highly consistent with the AERES principles. Its implementation, adapted to each type of activity (fundamental research, applied research, technological developments) allows the CEA to follow up a permanent improvement approach. (J.S.)

  13. Sensitivity and specificity of the GAMMACOAT-M CEA-RIA from Travenol-Genentech Diagnostics compared to the ABBOTT CEA-RIA monoclonal

    International Nuclear Information System (INIS)

    A new monoclonal radioimmunoassay from Travenol-Genentech Diagnostics was investigated with respect to its sensitivity and specificity and compared to the established monoclonal antibody assay of ABBOTT. Both tests revealed increased CEA plasma values in healthy smokers, whereby the elevation was dependent on the number of cigarettes smoked per day. The sensitivities as well as the cut-off levels for CEA at 90% specificity were coincident in both tests. (orig.)

  14. Application of monoclonal antibodies to purified CEA in clinical radioimmunoassay of human serum

    International Nuclear Information System (INIS)

    Double-antibody radioimmunoassay using a mouse monoclonal anti- CEA (MA/1) has been used to measure CEA in human serum. Low levels of MA/1-binding CEA have been found in serum from normal individuals and moderately raised levels are sometimes associated with certain non-malignant diseases. As with conventional anti-CEA, the MA/1 antibodies can recognize significant amounts of CEA in serum from patients with a variety of solid tumours. However they appear to recognize a different immunodeterminant and possibly a different population of CEA molecules to, or a subset of, those measured by two routine assays. Studies in which the MA/1 assay was directly compared with the results of the Charing Cross routine and Abbott EIA assays have indicated that different immunological forms of CEA may be expressed in the course of tumour progression but no prognostic value was evident in this study. The results stress the need to resolve immunological specificities expressed by CEA-like molecules and evaluate their clinical importance. (author)

  15. Assessment 2000 and regulation and method. Releases control and environmental survey of the CEA Centers

    International Nuclear Information System (INIS)

    The environment quality around the CEA centers is a major interest of its safety policy. These documents contribute to the public information on the radioactive liquid and gaseous releases of the CEA, according to the ministry authorization. The radioactivity monitoring activity, and the survey methods are also presented. Data analysis from 1996 to 2000, allows to follow the evolution. (A.L.B.)

  16. General rules for radiation protection within the CEA

    International Nuclear Information System (INIS)

    This report first describes the organisation, scope of application and principles of radiation protection within the CEA. The second part proposes an overview of rules applicable to workers exposed to ionizing radiation. These rules concern the personnel classification, exposure limits, individual control, and training of workers in radiation protection. The third part addresses the technical rules for premise laying-out: protection zoning, indicators aimed at controlling the compliance of premise classification, radiological survey and control of premise classification. The fourth part addresses the modalities of access, stay and operation in regulated zone. The next part indicates and comments arrangements specific to ionizing radiation sources and to ionizing radiation emitting equipment (authorization and possession modalities, training, certification, controls, operation zoning, etc.), specific orders (radiological control of wastes, hardware, tools and equipment management), rules related to abnormal occupational situations (alarms, contamination event, radiological events), and the different studies and analysis of radiation protection implemented during the different phases of an installation lifetime

  17. Report on transparency and nuclear safety 2014 - Cadarache CEA centre

    International Nuclear Information System (INIS)

    This document proposes, first, a presentation of the Cadarache CEA centre, of its activities and installations, gives a rather detailed overview of measures related to safety and to radiation protection within these activities and installations. Then it reports significant events related to safety and to radiation protection which occurred in 2014 and have been declared to the ASN. Next, it discusses the results of release measurements (liquid and gaseous effluents, radiological assessment, and chemical assessment for various installations) and the control of the chemical and radiological impact of these gaseous and liquid effluents on the environment. Finally, it addresses the issue of radioactive wastes which are stored in the different nuclear base installations of the Centre, indicates the different measures aimed at limiting the volume of these warehoused wastes and addresses their impact on health and on the environment. Nature and quantities of warehoused wastes are specified. Remarks and recommendations of the CHSCT are given

  18. Cryogenic turbulence test facilities at CEA/SBT

    Science.gov (United States)

    Rousset, B.; Baudet, C.; Bon Mardion, M.; Bourgoin, M.; Braslau, A.; Daviaud, F.; Diribarne, P.; Dubrulle, B.; Gagne, Y.; Gallet, B.; Gibert, M.; Girard, A.; Lehner, T.; Moukharski, I.; Sy, F.

    2015-12-01

    Recently, CEA Grenoble SBT has designed, built and tested three liquid helium facilities dedicated to turbulence studies. All these experiments can operate either in HeI or HeII within the same campaign. The three facilities utilize moving parts inside liquid helium. The SHREK experiment is a von Kármán swirling flow between 0.72 m diameter counterrotating disks equipped with blades. The HeJet facility is used to produce a liquid helium free jet inside a 0.200 m I.D., 0.47 m length stainless steel cylindrical testing chamber. The OGRES experiment consists of an optical cryostat equipped with a particle injection device and an oscillating grid. We detail specific techniques employed to accommodate these stringent specifications. Solutions for operating these facilities without bubbles nor boiling/cavitation are described. Control parameters as well as Reynolds number and temperature ranges are given.

  19. The stationary storage of energy. Available technologies and CEA researches

    International Nuclear Information System (INIS)

    After a discussion of the main challenges related to the stationary storage of energy, this publication proposes an overview of the different available technologies: plant for transfer of energy by pumping, compressed air, energy flywheels, hydrogen, lithium-ion battery, redox-flow battery, thermal storage by sensitive heat, thermal-chemical storage coupled to a thermal solar system, thermal storage by phase change, superconductive inductance storage, super-capacitors. It discusses the criteria of choice of storage technology, either for electric energy storage or for heat storage. It proposes an overview of researches performed within the CEA on storage systems: electrochemical, thermal, and hydrogen-based storages. The final chapter addresses current fundamental researches on storage in the field of lithium-ion batteries, hydrogen as a fuel, and thermoelectricity

  20. Recent advances in indirect drive ICF target physics at CEA

    International Nuclear Information System (INIS)

    The objective of Target Physics Program at CEA is the achievement of ignition on the LMJ, a glass laser facility of 1.8 MJ which will be completed by 2008. It is composed of theoretical work, experimental work and numerical simulations. An important part of experimental studies is made in collaboration with U.S. DOE Laboratories: Lawrence Livermore National Laboratory, Los Alamos National Laboratory and the Laboratory for Laser Energetics at the University of Rochester. Experiments were performed on Phebus, NOVA (LLNL) and OMEGA (LLE) ; they included diagnostics developments. Recent efforts have been focused on Laser Plasma Interaction, hohlraum energetics, symmetry, ablator physics and hydrodynamic instabilities. Ongoing work prepare the first experiments on the LIL which is a prototype facility of the LMJ (8 of its 240 beams). They will be performed by 2002. Recent progress in ICF target physics allows us to precise laser specifications to achieve ignition with reasonable margin. (author)

  1. Progress in fusion reactors blanket analysis and evaluation at CEA

    International Nuclear Information System (INIS)

    In the frame of the recent CEA studies aiming at the development, evaluation and comparison of solid breeder blanket concepts in view of their adaptation to NET, and the evaluation of specific questions related to the first wall design, the present paper examines first the performances of a helium cooled toroidal blanket design for NET, based on innovative Beryllium/Ceramics breeder rod elements. Neutronic and thermo-mechanical optimisation converges on a concept featured by a breeding capability in excess of 1.2, a reasonnable pumping power of 1 % and a narrow breeder temperature range (470 +- 30 0C of the breeder), the latter being largely independent of the power level. The final section of the paper is devoted to the evaluation of the heat load poloidal distribution and to the irradiation effects on first wall structural materials

  2. CEA contribution to the ITER ICRH antenna design

    International Nuclear Information System (INIS)

    The ITER ion-cyclotron range of frequency (ICRH) heating system is required to couple 20 MW of power in the frequency range 40–55 MHz for a large range of scenarios with Edge Localized Modes. To mitigate the associated risks, it is foreseen to design and install on ITER two port-plug antennas for a total of 20 MW coupled power on long pulse operation [1]. The CEA activity to this antenna design within the CYCLE consortium was focused on the Faraday screen design (Fig. 1) and associated radio frequency (RF) sheath modelling, the reflectometers design for edge density measurement in the antenna vicinity and a contribution to the remote handling/tooling of the antenna. This paper is an overview of each item and proposes some R and D activities on key components

  3. Planta de lavado para arena silícea

    OpenAIRE

    Rojo García, Cristina

    2008-01-01

    El proyecto fin de carrera trata sobre la instalación de una planta móvil de lavado para arena silícea. Este recurso está presente en el Monte Público nº 90 denominado “RAJICA DE EN MEDIO” en el Término Municipal de Jumilla (Murcia), donde se ubica la cantera “Los Mochuelos” de la que es concesionaria y explotadora la empresa JUMILLANA DE SÍLICE, S.L, con C.I.F. nº B-25.646.720, con domicilio social en C/ Canalejas nº 83, Bajo, de Jumilla (Murcia). Por ello, el presente proyecto tien...

  4. Development of radiolabelling techniques of anti-CEA monoclonal antibody

    International Nuclear Information System (INIS)

    The purpose of this work was to label monoclonal and polyclonal antibodies with 99Tcm such as the ior-CEA-1 antibody and polyclonal IgG using a direct method, to check the radiochemical and biological behavior of labelled products, to prepare it under sterile and apyrogenic conditions as a lyophilized kit and to employ it in clinical trials. In addition, a photoactivation method was used to label polyclonal IgG with 99Tcm and to compare with the established method using mercaptoethanol (2-ME) as the reducing agent. Finally polyclonal IgG was labelled using an indirect method in which a chelator was covalently attached to the protein and the 99Tcm added as glucoheptonate complex. The properties of 99Tcm when labelled with monoclonal and polyclonal antibodies by different methods were assessed by in vitro and in vivo studies

  5. Experimental Feedback on Sodium Loop Decommissioning at the CEA

    International Nuclear Information System (INIS)

    The aim of this paper is to present experimental feedback on sodium loop dismantling techniques at the CEA (The French Atomic Energy Commission) and to offer recommendations for the decommissioning of Fast Breeder Reactor secondary sodium loops. This study is divided into several parts which correspond to the different stages of a dismantling system. It is based on acquired CEA decommissioning experience which primarily concerns the following: the decommissioning of Rapsodie (France's first Fast Breeder Reactor), the Phenix reactor secondary loop replacement, the sodium loop decommissioning carried out by the Laboratory of Sodium Technologies and Treatment, and several technical documents. This paper deals with the main results of this survey. First, a comparison of 8 pipe-cutting techniques is made, taking into account speed in cutting, reliability, dissemination, fire risk due to the presence of sodium, cutting depth, and different types of waste (empty pipes, sodium-filled pipes, tanks...). This comparison has led us to recommend the use of an alternative saw or a chain saw rather than the use of the plasma torch or grinder. Different techniques are recommended depending on if they are on-site, initial cuttings or if they are to be carried out in a specially-designed facility referred to hereafter as 'the cutting building'. After the cutting stage, the sodium waste must be processed with water to become an ultimate stable waste. Four treatment processes are compared with different standards: speed, cost, low activity adaptability and 'large sodium quantity' adaptability. Recommendations are also made for reliable storage, and for the general dismantling system organization. Last, calculations are presented concerning a complete dismantling facility prototype capable of treating large amounts of sodium. (authors)

  6. DOE–CEA Benchmark on SFR ASTRID Innovative Core: Neutronic and Safety Transients Simulation

    International Nuclear Information System (INIS)

    ASTRID is a fast reactor being designed by the CEA to achieve a level of safety that exceeds that of conventional fast reactors. In particular, an axially heterogeneous core with an upper sodium plenum is employed to achieve a non-positive sodium void reactivity worth. In order to address the simulation challenges for this innovative concept, the US Department of Energy’s (DOE) Laboratories (Argonne National Laboratory and Idaho National Laboratory) and the CEA are performing neutronic and transient benchmark calculations for an ASTRID model based on design specifications provided by the CEA. The blind comparison of the initial DOE and CEA results are found to be in good agreement, enhancing confidence in CEA predictions of key ASTRID safety relevant parameters and transient behaviour. For several parameters, compared uncertainties in computed values are significant and further studies are needed to reduce them. (author)

  7. Overview of the long-lived radionuclide separation processes developed in connection with the CEA`s spin programme

    Energy Technology Data Exchange (ETDEWEB)

    Madic, C.; Bourges, J.; Dozol, J.F.

    1994-12-31

    One possible strategy for eliminating the long-term potential hazards associated with the storage of vitrified high level waste produced by the processing of irradiated nuclear fuels, is the transmutation of the long-life radionuclides in these wastes into short-life radionuclides by nuclear means, which requires the prior chemical separation of these long-life radionuclides from the nuclear waste mixture. To do this, the French CEA (Atomic Energy Commissionership) launched the SPIN (Separation-Incineration) research programme in 1991, under the law passed by the parliament on december 30, 1991. Research currently under way to develop separation processes for some long-life radionuclides concerns modifications of the Purex process, and the development of new solvent extraction processes. The research directions are briefly summarized here. (authors). 17 refs., 3 tabs.

  8. Selectively assaying CEA based on a creative strategy of gold nanoparticles enhancing silver nanoclusters' fluorescence.

    Science.gov (United States)

    Yang, Xiaoming; Zhuo, Yan; Zhu, Shanshan; Luo, Yawen; Feng, Yuanjiao; Xu, Yan

    2015-02-15

    Herein, we have successfully built up connections between nanoparticles and nanoclusters, and further constructed a surface-enhanced fluorescence (SEF) strategy based on the two types of nanomaterials for selectively assaying carcinoembryonic antigen (CEA). Specifically, silver nanoclusters provided the original fluorescence signal, while gold nanoparticles modified with DNA served as the fluorescence enhancer simultaneously. On the basis of this proposed nano-system, the two nanomaterials were linked by CEA-aptamer, thus facilitating SEF occurring. Nevertheless, more competitive interactions between CEA and CEA-aptamer emerged once CEA added, leading to SEF failed and their fluorescence decreased. Significantly, this creative method was further applied to detect CEA, and showed the linear relationship between the fluorescence intensity and CEA concentrations in the range of 0.01-1 ng mL(-1) with a detection limit of 3 pg mL(-1) at a signal-to-noise ratio of 3, demonstrating its sensitivity and promising towards multiple applications. On the whole, this approach we established may broaden potential ways of combining nanoparticles and nanoclusters for detecting trace targets in bioanalytical fields. PMID:25259877

  9. CHARACTERIZATION OF MONOCLONAL ANTIBODY CL58 AGAINST CARCINOEMBRYONIC ANTIGEN (CEA) AND STUDY OF ITS BIODISTRIBUTION

    Institute of Scientific and Technical Information of China (English)

    李振甫; 杨志; 张宏; 顾晋

    2002-01-01

    Objective: To study the preparation and characterization of monoclonal antibody (McAb) against carcinoembryonic antigen (CEA). Methods: CEA antigen was extracted from metastasized liver of patients with colorectal cancer and used for the preparation of McAb against CEA by hybridoma technique. Immunoreactivity of McAb to CEA antigen was evaluated using ELISA. Mouse ascites was purified by two steps, high performance liquid chromatography (HPLC) using protein A and high performance hydroxylapatite (HPHT). Normal adult tissues and tumor specimen were used for immunohistochemical evaluation of the McAb. Isotope 99mTc labeled CEA McAb was used for biodistribution in tumor-bearing mouse. Results: Purified CEA antigen was a glycoprotein of 180 kD. Anti-CEA McAb affinity constant was 7.4x109/M. The McAb showed positive staining in 54-88% of colorectal cancer, gastric cancer and lung cancer, while negative for normal tissues. 24 hours after injection of 99mTc labeled McAb, tumor ID%/g was higher than 15% and tumor/blood, tumor/kidney and tumor/liver were 1.82, 1.51 and 2.92 respectively. T/NT ratios of other viscera were over 3.0. Conclusion: Purified CEA antigen had very good immunogenicity. The anti-CEA McAb was highly specific. 99mTc labeled McAb was stabled both in vivo and in vitro. In vivo distribution result was satisfactory. McAb CL58 may be useful for RII and RIGS.

  10. Preparation of 99mTc-Anti CEA MAb and biodistribution test in mice

    International Nuclear Information System (INIS)

    99mTc-antiCEA MAb radiopharmaceutical has been commercially used under the brand name of Zevalin which is used to detect colorectal cancer. Although human MAb is preferred but commercial product is still using murine originated MAb. This antibody binds specifically to carcinoembryonic antigen (CEA) which is overexpressed in colorectal cancer cells. AntiCEA MAb was reduced with diluted 2-mercaptoethanol (1:2000) prior to labelling with 99mTc, and MDP was used as transchelating agent. Labeling efficiency was analysed with chromatography using HSA impregnated ITLC-SG as stationary phase and mixture of ammona-ethanol-water (1:2:5) as eluants to determine polar 99mTc impurities, and ITLC-SG eluted with salin to determine 99mTc-colloid. Stability study was carried out on radio labeled antiCEA MAb stored at room temperature within several hours and on reduced antiCEA MAb stored at -40°C for several weeks. Biodistribution of 99mTc-antiCEA MAb in normal mice was observed 1 hour and 4 hours post injection. Labeling efficiency of antiCEA MAb was 98,53% ± 0.21 % and decreasing to less than 90% after 9 weeks. Radiolabeled anti CEA MAb kept at room temperature was stable within 5 hours post injection, and the frozen kits were stable up to 9 weeks. Biodistribution of 99mTc-antiCEA MAb in normal mice at 1 hour and 4 hours post injection showed high uptake in various organs. (author)

  11. Fusion technology. Annual report of the. Association Cea/EURATOM; Technologie de fusion.Rapport annuel de l`association CEA/Euratom

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le Vagueres, F.

    1996-12-31

    In 1996, the French EURATOM-CEA Association made significant contributions to the European technology programme. This work is compiled in this report as follows: the ITER CEA activities and related developments are described in the first section; blankets and material developments for DEMO, long term safety studies are summarised in the second part; the Underlying Technology activities are compiled in the third part of this report. In each section, the tasks are sorted out to respect the European presentation. For an easy reading, appendix 4 gives the list of tasks in alphabetical order with a page reference list. The CEA is in charge of the French Technology programme. Three specific organizational directions of the CEA, located on four sites (see appendix 5) are involves in this programme: Advanced Technologies Direction (DTA), for Material task; Nuclear Reactors Direction (DRN), for Blanket design, Neutronic problems, Safety tasks; Physical Sciences Direction (DSM) uses the competence of the Tore Supra team in the Magnet design and plasma Facing Component field. The CEA programme is completed by collaborations with Technicatome, COMEX-Nucleaire and Ecole Polytechnique. The breakdown of the programme by Directions is presented in figure 1. The allocation of tasks is given in appendix 2 and in appendix 3, the related publications. (author).

  12. Imaging of pharyngeal and laryngeal carcinomas with indium-111-labeled monoclonal anti-CEA antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Kairemo, K.J.; Hopsu, E.V. (Helsinki Univ. Central Hospital (Finland))

    1990-10-01

    Localization of primary tumors, metastases, or recurrences in 13 consecutive patients with histological verification of squamous cell or adenocarcinoma was made with radioimmunodetection using monoclonal radiolabeled anti-CEA antibody. All surgical specimens stained immunohistochemically, except one, were positive for CEA. Of the known 19 tumor sites 17 were visualized in antibody scans. There were two positive findings that did not prove to be positive during 12 month follow-up. The scintigram findings did not correlate with CEA serum concentrations that, with one exception, were normal in all patients.

  13. Imaging of pharyngeal and laryngeal carcinomas with indium-111-labeled monoclonal anti-CEA antibodies

    International Nuclear Information System (INIS)

    Localization of primary tumors, metastases, or recurrences in 13 consecutive patients with histological verification of squamous cell or adenocarcinoma was made with radioimmunodetection using monoclonal radiolabeled anti-CEA antibody. All surgical specimens stained immunohistochemically, except one, were positive for CEA. Of the known 19 tumor sites 17 were visualized in antibody scans. There were two positive findings that did not prove to be positive during 12 month follow-up. The scintigram findings did not correlate with CEA serum concentrations that, with one exception, were normal in all patients

  14. Report on transparency and nuclear safety - Cadarache CEA centre - 2012

    International Nuclear Information System (INIS)

    A first volume proposes a presentation of the Cadarache CEA centre, of its activities and installations, gives a rather detailed overview of measures related to safety and to radiation protection within these activities and installations. It also reports significant events related to safety and to radiation protection which occurred in 2012 and have been declared to the ASN. It discusses the results of release measurements (liquid and gaseous effluents, radiological assessment, and chemical assessment for various installations) and the control of the chemical and radiological impact of these gaseous and liquid effluents on the environment. It addresses the issue of radioactive wastes which are stored in the different nuclear base installations of the Centre, indicates the different measures aimed at limiting the volume of these warehoused wastes and addresses their impact on health and on the environment. Nature and quantities of warehoused wastes are specified. The second volume concerns some specific installations (INB 32 or ATPu, and INB 54 or LPC) which belong to AREVA NC. The same topics are addressed: presentation of the facilities, arrangements regarding safety and radiation protection, significant events related to safety and radiation protection, measurements of effluents and their impact on the environment, warehoused wastes. Remarks and recommendations of the CHSCT are given

  15. Progress in fusion reactors blanket analysis and evaluation at CEA

    International Nuclear Information System (INIS)

    In the frame of the recent CEA studies aiming at the development, evaluation and comparison of solid breeder blanket concepts in view of their adaptation to NET, the evaluation of specific questions related to the first wall design, the present paper examines first the performances of a helium cooled toroidal blanket design for NET, based on innovative Beryllium/Ceramics breeder rod elements. Neutronic and thermo-mechanical optimisation converges on a concept featured by a breeding capability in excess of 1.2, a reasonnable pumping power of 1% and a narrow breeder temperature range (470+-30 deg C of the breeder), the latter being largely independent of the power level. This design proves naturally adapted to ceramic breeder assigned to very strict working conditions, and provides for any change in the thermal and heat transfer characteristics over the blanket lifetime. The final section of the paper is devoted to the evaluation of the heat load poloidal distribution and to the irradiation effects on first wall structural materials

  16. CEA distribution transformer purchasing specifications (DTWG-01,02,03)

    International Nuclear Information System (INIS)

    Purchasing specifications for three types of distribution transformers are presented. The specifications were compiled by the Canadian Electricity Association at the suggestion made in 1989 by the Canadian Utilities Material Management Group. The specifications cover pole mounted single phase distribution transformers (DTWG-01), low-profile, single phase, dead-front pad-mounted distribution transformers (DTWG-02), and three phase, dead-front pad-mounted distribution transformers (DTWG-03). The specifications were compiled by a task force of CEA member utilities, using CSA standards as the governing standards in all three cases. The first edition of the purchasing specifications was issued in 1993. The second edition, consisting mainly of revisions based on experiences learned from using the first edition, and the addition of the appropriate clauses of CSA standards, was published in 1998. Based on a three-year average of the number of transformers purchased annually (about 58,000) at an estimated total cost of $ 120 million, use of the Purchasing Specifications is said to have resulted in savings of about 7 per cent or $ 8.4 million

  17. The use and evolution of the CEA research reactors

    International Nuclear Information System (INIS)

    The authors successively examine the different research reactors in use in the French C.E.A. Nuclear Centres. They trace briefly their histories, describing how they have been used up to the present, and how they have been adapted to changes in programme by means of certain modifications. They also describe the reasons which have led to the elaboration of the project for the new reactor Osiris. Zoe, the oldest reactor in the CEA, has been in service in the Centre de Fontenay-aux-Roses since 1948. It is used mainly for measurements of absorption cross-sections in graphite, and for various short irradiations which do not require high fluxes. The reactor EL 2, in service since 1952, was used for the first studies on gas cooling. It has also been widely used for the production of radioisotopes and for a large number of experiments in the fields of physics, metallurgy and physical chemistry. The ageing of certain elements of the reactor has led to the decision to close it down in the near future The reactor EL 3 has been widely used for experiments in physics and in the investigation of fuels. The possibilities of the reactor in fast neutron irradiations will be considerably improved by the adoption of a new type of core (the 'snow crystal' structure). Triton-I, a 2 MW swimming-pool reactor, is used for the most part for fast neutron and gamma irradiations. The modifications being carried out on it at present should result in an increase in the power of the reactor up to 4 or 5 MW. In a neighbouring compartment is housed Triton-II which is of the same general structure, as Triton-I, but whose maximum power is 100 kW. Triton-II is used solely for studies on shielding. Melusine, a 2 MW swimming-pool reactor, has been in use in the Centre d'Etudes Nucleaires de Grenoble since 1959. It has supported a very high programme concerned mainly with solid state physics, fundamental research into refractory fissile materials and special graphites, and the study of the behaviour of

  18. The possibility of complementary CEA/PSI physics experiments

    International Nuclear Information System (INIS)

    The zero-power, PROTEUS, is a versatile critical facility for providing integral data to test calculational methods and data used in the neutronics design of standard and advanced reactor systems. An experimental programme is planned for PROTEUS with the main aim to support the Swiss nuclear power plants in questions addressing the neutron physics of new, highly heterogeneous BWR fuel-assemblies in order to reduce the conservations included in the margins to operational limits, on the one hand, as well as special investigations in MOX recycling LWR cores, on the other hand. A second objective considers R+D-contributions to the neutron physics of advanced LWR fuel cycles. In recent years, experiments relating to MOX recycling in PWRs have been performed on the EOLE facility at the Nuclear Research Centre in Cadarache. A five years programme is now planned for the EOLE facility with the aim to study and validate 100% MOX fuel recycling in PWRs. Some experiments will be performed in the PROTEUS facility in co-operation with CEA to complement the measurements in the EOLE facility, addressing questions such as: - intercomparison of standard experimental techniques to reduce systematic errors, - data validation through measurements of non-standard reaction rates in normal, under- and over-moderated LWR-spectra, - void simulation experiments using special techniques, - studies on the reduction of radiation damage on the reactor pressure vessel for 100% MOX cores, by introducing steel baffles between the core boundary and the reactor pressure vessel. (author) 2 figs., 10 refs

  19. The contract State-CEA 2001-2004 for the civil activities; Le contrat etat-Cea 2001-2004 pour les activites civile

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-02-19

    The 25 january 2001, the CEA signed its pluri-annual contract with the State. Apply some to the complete document, this paper deals with the part concerning the energy. The main objective concerns the radioactive wastes management and the mastership of the nuclear activities impacts. The other part is devoted to the research programs and the technology for the industrial innovation. In this framework the CEA have to develop its program on the new following technologies: hydrogen and fuel cells, photovoltaic and storage, energy conservation. A part of the contract concerns also the fundamental research on spallation and transmutation. (A.L.B.)

  20. Anti-CEA loaded maghemite nanoparticles as a theragnostic device for colorectal cancer

    Directory of Open Access Journals (Sweden)

    Campos da Paz M

    2012-10-01

    Full Text Available Mariana Campos da Paz,1 Maria de Fátima M Almeida Santos,1 Camila MB Santos,2 Sebastião W da Silva,2 Lincoln Bernardo de Souza,3 Emília CD Lima,3 Renata C Silva,1 Carolina M Lucci,1 Paulo César Morais,2 Ricardo B Azevedo,1 Zulmira GM Lacava11Instituto de Ciências Biológicas; 2Instituto de Física, Universidade de Brasília, Brasília, DF, Brazil; 3Instituto de Química, Universidade Federal de Goiás, Goiânia, GO, BrazilAbstract: Nanosized maghemite particles were synthesized, precoated (with dimercaptosuccinic acid and surface-functionalized with anticarcinoembryonic antigen (anti-CEA and successfully used to target cell lines expressing the CEA, characteristic of colorectal cancer (CRC cells. The as-developed nanosized material device, consisting of surface decorated maghemite nanoparticles suspended as a biocompatible magnetic fluid (MF sample, labeled MF-anti-CEA, was characterized and tested against two cell lines: a high-CEA expressing cell line (LS174T and a low-CEA expressing cell line (HCT116. Whereas X-ray diffraction was used to assess the average core size of the as-synthesized maghemite particles (average 8.3 nm in diameter, dynamic light scattering and electrophoretic mobility measurements were used to obtain the average hydrodynamic diameter (550 nm and the zeta-potential (−38 mV of the as-prepared and maghemite-based nanosized device, respectively. Additionally, surface-enhanced Raman spectroscopy (SERS was used to track the surface decoration of the nanosized maghemite particles from the very first precoating up to the attachment of the anti-CEA moiety. The Raman peak at 1655 cm−1, absent in the free anti-CEA spectrum, is the signature of the anti-CEA binding onto the precoated magnetic nanoparticles. Whereas MTT assay was used to confirm the low cell toxicity of the MF-anti-CEA device, ELISA and Prussian blue iron staining tests performed with both cell lines (LS174T and HCT116 confirm that the as-prepared MF-anti-CEA

  1. Network and system diagrams revisited: Satisfying CEA requirements for causality analysis

    International Nuclear Information System (INIS)

    Published guidelines for Cumulative Effects Assessment (CEA) have called for the identification of cause-and-effect relationships, or causality, challenging researchers to identify methods that can possibly meet CEA's specific requirements. Together with an outline of these requirements from CEA key literature, the various definitions of cumulative effects point to the direction of a method for causality analysis that is visually-oriented and qualitative. This article consequently revisits network and system diagrams, resolves their reported shortcomings, and extends their capabilities with causal loop diagramming methodology. The application of the resulting composite causality analysis method to three Environmental Impact Assessment (EIA) case studies appears to satisfy the specific requirements of CEA regarding causality. Three 'moments' are envisaged for the use of the proposed method: during the scoping stage, during the assessment process, and during the stakeholder participation process

  2. Comparison of Ablation Predictions for Carbonaceous Materials Using CEA and JANAF-Based Species Thermodynamics

    Science.gov (United States)

    Milos, Frank S.

    2011-01-01

    In most previous work at NASA Ames Research Center, ablation predictions for carbonaceous materials were obtained using a species thermodynamics database developed by Aerotherm Corporation. This database is derived mostly from the JANAF thermochemical tables. However, the CEA thermodynamics database, also used by NASA, is considered more up to date. In this work, the FIAT code was modified to use CEA-based curve fits for species thermodynamics, then analyses using both the JANAF and CEA thermodynamics were performed for carbon and carbon phenolic materials over a range of test conditions. The ablation predictions are comparable at lower heat fluxes where the dominant mechanism is carbon oxidation. However, the predictions begin to diverge in the sublimation regime, with the CEA model predicting lower recession. The disagreement is more significant for carbon phenolic than for carbon, and this difference is attributed to hydrocarbon species that may contribute to the ablation rate.

  3. Numerical Platon: A unified linear equation solver interface by CEA for solving open foe scientific applications

    International Nuclear Information System (INIS)

    This paper describes a tool called 'Numerical Platon' developed by the French Atomic Energy Commission (CEA). It provides a freely available (GNU LGPL license) interface for coupling scientific computing applications to various freeware linear solver libraries (essentially PETSc, SuperLU and HyPre), together with some proprietary CEA solvers, for high-performance computers that may be used in industrial software written in various programming languages. This tool was developed as part of considerable efforts by the CEA Nuclear Energy Division in the past years to promote massively parallel software and on-shelf parallel tools to help develop new generation simulation codes. After the presentation of the package architecture and the available algorithms, we show examples of how Numerical Platon is used in sequential and parallel CEA codes. Comparing with in-house solvers, the gain in terms of increases in computation capacities or in terms of parallel performances is notable, without considerable extra development cost

  4. Scientific evaluation at the French Atomic Energy Commission (CEA). 2005-2006 annual report

    International Nuclear Information System (INIS)

    This report aims at presenting the scientific evaluation activities carried out at the CEA during the years 2005-2006. The evaluation system is described in detail. It comprises two aspects: the evaluation of the scientific policy implemented by the scientific Council and by the visiting committee of the CEA, and the evaluation of the laboratories, performed by a pool of 36 scientific councils. The evaluation by external and independent parties is the key point of this system. This document makes a status of the evaluations performed in 2005 and 2006. It presents a synthesis of the conclusions of the evaluation authorities. The actions implemented by the CEA to take into consideration the recommendations are also reported with the improvements noticed. The two topics examined by the scientific Committee and by the visiting committee were dealing with the energy domain, which is a strategic issue for the CEA. The examination of the researches on future nuclear reactors and on new energy technologies have shown the major role played by the CEA in the recent advances in these domains. About 95% of the laboratories activity was examined during the 2002-2005 period. The richness of the remarks and recommendations made by the scientific councils should allow the CEA to improve the quality and relevance of its research works. The start-up of the 2006-2009 evaluation cycle has been the occasion to modify the evaluation of some research domains in order to take into account the evolution of programs. The evaluation system of the CEA is highly consistent with the AERES principles. Its implementation, adapted to each type of activity (fundamental research, applied research, technological developments) allows the CEA to follow up a permanent improvement approach. (J.S.)

  5. Summary 1998. Releases control and environment monitoring for the CEA Centers

    International Nuclear Information System (INIS)

    In the framework of its environmental policy, the CEA aims at reduce as weak as possible, in regards to the technological and economic needs, its activities impacts on the people and the environment. This paper contributes to the public information on the radioactive gaseous and liquid releases during the year 1998. It presents data on the releases and the radioactivity levels around the CEA sites and gathers the associated regulation and monitoring methods. (A.L.B.)

  6. Integral needs for MOX powders: state of the art at Cea Cadarache on MOX fuel experiments

    International Nuclear Information System (INIS)

    Several experimental programmes have been conducted at CEA connected with the use of MOX in commercial PWR or innovative concepts, such as high conversion light water reactors (HCLWRs) and at various moderation ratios. Measurements of integral parameters of interest were performed using fission chambers and gamma-scanning techniques, or by oscillation techniques. This paper presents an overview of the experimental programmes performed at the EOLE and MINERVE facilities located at CEA Cadarache. (author)

  7. Unusual elevation of CEA in a patient with history of colon cancer.

    Science.gov (United States)

    Hsu, Tzu-Chi

    2006-12-01

    A 35-year-old female received right hemicolectomy for a poorly differentiated adenocarcinoma of the ascending colon with lymph node metastasis (1/28) in February 1997. CEA was 1.68 ng/microl prior to colectomy. Adjuvant chemotherapy with weekly 5-FU and leucovorin intravenously was started following surgery and discontinued after 17 doses in May 1997. She received bilateral salpingo-ophorecctomy for metastatic cancer in August 1999. Intravenous chemotherapy was resumed with weekly 5-FU and leucovorin intravenously in August 1999. CEA was 93.8 ng/microl in November 1999. Intravenous chemotherapy was discontinued after 20 doses and oral chemotherapy with futraful and leucovorin was started in January 2000. CEA was found to be 240.3 ng/microl in December 1999 and then elevated to 1521.3 ng/microl in June 2001, which was 10 months after resection of metastatic ovarian cancer. No metastatic lesions could be detected, however, with image studies. The CEA decreased to 396.6 ng/microl three months later. Futraful was switched to uracil-tegafur (UFUR) in September 2001. The CEA for the patient ranged from 68.5 to 298.9 ng/microl for the following 5 years without aggressive chemotherapy. No evidence of recurrence could be demonstrated by imaging studies. The patient is not a smoker and denied exposure to a smoking environment. She was also not known to have persistent infections, inflammatory bowel disease, pancreatitis, cirrhosis of the liver, or any benign tumors. The current case suggested that: (i) elevation of CEA is not necessarily well correlated with presence of metastatic colon cancer; (ii) some patients may live with elevated CEA for years without evidence of recurrence or metastasis; (iii) aggressive chemotherapy may not be necessary in patients with only elevated CEA. PMID:17060406

  8. Blood CEA levels for detecting recurrent colorectal cancer: A Diagnostic Test Accuracy Review.

    OpenAIRE

    Nicholson, BD; Shinkins, B.; Pathiraja, I; Roberts, NW; James, T; Mallett, S.; Perera, R; Primrose, JN; Mant, D

    2015-01-01

    Background Testing for carcino-embryonic antigen (CEA) in the blood is a recommended part of follow-up to detect recurrence of colorectal cancer following primary curative treatment. There is substantial clinical variation in the cut-off level applied to trigger further investigation. Objectives To determine the diagnostic performance of different blood CEA levels in identifying people with colorectal cancer recurrence in order to inform clinical practice. Search methods W...

  9. CEA, a Major Player in Technological Innovation for Defense and Security

    International Nuclear Information System (INIS)

    The Secure Day Conference held in Paris on October 24, 2012 was organized by CEA with the support of the French High Committee for Civil Defense (Haut Comite Francais pour la Defense Civile - HCFDC). The event gathered more than 250 people (institutions, users and industrial companies) and alternated conferences and presentations on about thirty technologies developed in the framework of joint ministerial CBRN-E R and D program entrusted to CEA by public authorities. (authors)

  10. Elevated Level of Serum Carcinoembryonic Antigen (CEA) and Search for a Malignancy: A Case Report.

    Science.gov (United States)

    Asad-Ur-Rahman, Fnu; Saif, Muhammad W

    2016-01-01

    Carcinoembryonic antigen (CEA) has been shown to be associated with tumor burden in patients with colorectal cancer. However, it is also elevated to a significant degree in a number of other malignant and non-malignant conditions. We report a case of reversible CEA elevation in a patient using lithium for bipolar disorder. A 58-year-old female with a longstanding smoking history and a past medical history of chronic obstructive pulmonary disease (COPD), bipolar illness, hypothyroidism, and obesity was found to have an elevated CEA level of 11.2 ng/ml (normal level studies to evaluate for colorectal, breast, ovarian, and lung cancer; however, it did not reveal any evidence of malignancy. Upon review of her medications, she reported that she had recently started lithium for her bipolar illness. We followed up her CEA level while her dose of lithium was reduced from 450 to 300 mg per day. Her CEA level decreased from 25 mg/dl to 6.1 mg/dl and remained stable over the course of the next eight months. Our case is the first case report that identifies lithium as a potential cause of reversible CEA elevation. The underlying mechanism is yet to be elucidated, but it underscores the importance of investigating the medications as part of the workup. PMID:27446768

  11. Situation 2002: release monitoring and surveillance of environment of Cea centers; Bilan 2002: controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This publication renders an account of the situation of the releases of liquid and gaseous radioactive effluents, for the year 2002, as well as the radioactivity levels measured in the vicinity of Cea centers through the systematic surveillance of atmosphere, waters, vegetation and milk. An analysis on five years allows to follow their evolution. (N.C.)

  12. Melanoma cell surface-expressed phosphatidylserine as a therapeutic target for cationic anticancer peptide, temporin-1CEa.

    Science.gov (United States)

    Wang, Che; Chen, Yin-Wang; Zhang, Liang; Gong, Xian-Ge; Zhou, Yang; Shang, De-Jing

    2016-07-01

    We have previously reported that temporin-1CEa, a cationic antimicrobial peptide, exerts preferential cytotoxicity toward cancer cells. However, the exact molecular mechanism for this cancer-selectivity is still largely unknown. Here, we found that the negatively charged phosphatidylserine (PS) expressed on cancer cell surface serves as a target for temporin-1CEa. Our results indicate that human A375 melanoma cells express 50-fold more PS than non-cancerous HaCaT cells. The expression of cell surface PS in various cancer cell lines closely correlated with their ability to be recognized, bound and killed by temporin-1CEa. Additionally, the cytotoxicity of temporin-1CEa against A375 cells can be ameliorated by annexin V, which binds to cell surface PS with high affinity. Moreover, the data of isothermal titration calorimetry assay further confirmed a direct binding of temporin-1CEa to PS, at a ratio of 1:5 (temporin-1CEa:PS). Interestingly, the circular dichroism spectra analysis using artificial biomembrane revealed that PS not only provides electrostatic attractive sites for temporin-1CEa but also confers the membrane-bound temporin-1CEa to form α-helical structure, therefore, enhances the affinity and membrane disrupting ability of temporin-1CEa. In summary, these findings suggested that the melanoma cells expressed PS may serve as a promising target for temporin-1CEa or other cationic anticancer peptides. PMID:26596643

  13. Construction of CEA siRNA expression vector and its inhibitory effects on the expression of CEA in EC9706 cells%CEA siRNA载体的构建和转染人食管癌EC9706细胞的沉默作用

    Institute of Scientific and Technical Information of China (English)

    Guoqiang Zhao; Sajia Sun; Hong Zheng; Long Feng; Hongyan Yang; Ziming Dong

    2008-01-01

    Objective: To construct the small interfering RNA (siRNA) expression vector of carcino-embryonic antigen (CEA) and inhibit the expression of CEA in EC9706 cells by RNA interference. Methods: Two pairs of oligonucleotide sequences were designed and synthesized according to the encoding sequence of mRNA of CEA. The annealed oligonucleotide fragments were cloned into pRNAT-U6.2 expression vector and identified by sequencing. The recombinant plasmid pRNAT-U6.2-CEA was transfected into EC9706 cells. The expression of CEA in the stable transfected cells was assayed by real time PCR and Western blot. Results: DNA sequencing showed that the oligonucleotide fragments were correctly inserted into pRNAT-U6.2 vector, and CEA expression in the transfected cells was down-regulated significantly by pRNAT-U6.2-CEA at both the mRNA and protein levels. Conclusion: The siRNA expression vector of CEA is successfully constructed and inhibits CEA expression in EC9706 cells. This facilitates further studies of the function of CEA at the molecular level.

  14. Fitoplancton del Parque Nacional Las Tablas de Daimiel. II. Las cianofíceas, los dinoflagelados, las criptofíceas, las crisofíceas y las xantofíceas

    Directory of Open Access Journals (Sweden)

    Rojo, Carmen

    1999-12-01

    Full Text Available Las Tablas de Daimiel National Park is a semiarid wetland that exhibits a high biodiversity but is suffering an inexorable eutrophication process. The study of the phytoplankton in this wetland is interesting because of its hydrological fluctuations (drought period until 1996 and its trophic condition. This papers shows the taxonomy, dynamic, and ecology of microalgae in five áreas of the Park from 1996 to 1998, which allow comparisons to be made between the present state and the 1992-1993 period. Twelve taxa of Cyanophyta, 4 of Dynophyceae, 8 of Cryptophyceae, 5 of Chrysophyceae and one of Xanthophyceae were found. Almost all species have been already cited in Spain and are typical for eutrophic environments. Cyanophyceae and Cryptophyceae were the most important groups (Planktothrix agardhii, Anabaenopsis elenkinii, Cryptomonas erosa as the most common algae. Moreover, oscillatorial Cyanophyceae (in 1992 have been replaced by N-fixing nostocal ones, related to the high level of pollution found in recent years.El Parque Nacional Las Tablas de Daimiel es un humedal semiárido, importante reserva de biodiversidad que, sin embargo, está sufriendo un inexorable proceso de eutrofización. Su estado trófico, así como los cambios hidrológicos (sequía hasta 1996, hacen especialmente interesante el estudio de su microflora. Por ello, se ha llevado a cabo este trabajo sobre las poblaciones fitoplanctónicas en cinco puntos del Parque desde 1996 a 1998, que permite además la comparación con su estado en 1992-1993. Se encontraron 12 táxones de Cyanophyta, 4 de Dynophyceae, 8 de Cryptophyceae, 5 de Chrysophyceae y uno de Xanthophyceae. Casi todas las especies están citadas en España y son propias de ambientes eutróficos. Los grupos mejor representados fueron las cianobacterias y criptofíceas (Planktothrix agardhii, Anabaenopsis elenkinii y Cryptomonas erosa fueron las especies más conspicuas. Además, se observa un cambio de cianobacterias

  15. Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein

    International Nuclear Information System (INIS)

    CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. The human MA39 scFv, selected for its ability to recognize a CEA epitope expressed on human colon carcinomas, was first isolated from a large semi-synthetic ETH-2 antibody phage library, panned on human purified CEA protein. Subsequently, by in vitro mutagenesis of a gene encoding for the scFv MA39, a new library was established, and new scFv antibodies with improved affinity towards the CEA cognate epitope were selected and characterized. The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells. The binding affinity of the scFv E8 is in a range for efficient, in vivo, antigen capture in tumor cells expressing a shared epitope of the CEACAM1, 3 and 5 proteins. This new immunoreagent meets all criteria for a potential anticancer compound: it is human, hence poorly or not at all immunogenic, and it binds selectively and with good affinity to the CEA epitope expressed by metastatic melanoma and colon and lung carcinomas. Furthermore, its small molecular size should provide for efficient tissue penetration, yet give rapid plasma clearance

  16. Evaluation of the reliability concerning the identification of human factors as contributing factors by a computer supported event analysis (CEA)

    International Nuclear Information System (INIS)

    The project's objectives are the evaluation of the reliability concerning the identification of Human Factors as contributing factors by a computer supported event analysis (CEA). CEA is a computer version of SOL (Safety through Organizational Learning). Parts of the first step were interviews with experts from the nuclear power industry and the evaluation of existing computer supported event analysis methods. This information was combined to a requirement profile for the CEA software. The next step contained the implementation of the software in an iterative process of evaluation. The completion of this project was the testing of the CEA software. As a result the testing demonstrated that it is possible to identify contributing factors with CEA validly. In addition, CEA received a very positive feedback from the experts. (orig.)

  17. Clinical significance of joint detection of serum CEA, SCCA, and bFGF in the diagnosis of lung cancer

    OpenAIRE

    Zhao, Wei; Yu, Haixiang; Han, Zhifeng; Gao, Nan; Xue, Jinru; Wang, Yan

    2015-01-01

    Lung cancer is a type of malignant tumor with highest morbidity and mortality. This study tested three tumor marker levels including CEA, SCCA, and bFGF to explore their value in lung cancer diagnosis and pathological type judgment. Venous blood was extracted from lung cancer patients, lung benign lesion patients and healthy control. Electrochemiluminescence immunoassay was applied to detect serum CEA and SCCA content. ELISA was used to test serum bFGF level. Serum CEA, SCCA, and bFGF levels ...

  18. How to Add Value to your Business with CEA: A Practical Approach

    Directory of Open Access Journals (Sweden)

    Daniel Cardenas

    2010-04-01

    Full Text Available Companies are always trying to differentiate themselves from the rest of the pack by applying different strategies such as improving customer service, increasing the efficiency of their operations, or reducing their costs. Most of the time, however, these goals are competing against each other for scarce resources, and managers often need to decide to concentrate on one. A small company can effectively and simultaneously accomplish these goals for a fraction of the cost by implementing communications-enabled business processes or solutions, which are a set of technology components that add real-time networking functionality to applications. One particular implementation of this framework is the one provided by Coral CEA. Coral CEA is a business ecosystem anchored around CEA functionalities that are offered as building blocks, out-of-the-box components that link the capabilities and intelligence of networks platforms with the power of current applications to provide a new set of features and functionalities. In this article, we show how a small company called Rezact, located in the ski resort town of Mont-Tremblant, Quebec, successfully implemented CEA capabilities within its own operations using Coral CEA services.

  19. Technetium-99m labelling of the ior-CEA-1 monoclonal antibody: Evaluation of different methods

    International Nuclear Information System (INIS)

    In the present work, we evaluated the influence of experimental conditions on the characteristics of the radiolabelled ior-CEA-1 prepared by direct method, using 2-ME and stannous chloride as reductants and indirect method in which 2-IM is used to generate sulfhydryl groups in the protein. The following parameters were studied: number of free sulfhydryl groups of treated antibody, labelling efficiency, chemical and radiochemical composition of the radiolabelled antibodies as well as their immunological and biological properties. The properties of 99Tcm-ior-CEA-1 obtained by 2-ME method were compared to the ones of the 99Tcm-monoclonal antibody obtained from a commercial kit (BW 431/26). Some clinical studies using 99Tcm-ior-CEA-1 were also performed

  20. Updated on effluents releases of the CEA nuclear fuel cycle facilities - 1995 to 2010 period

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Nelson Luiz Dias [Centro Tecnologico da Marinha em Sao Paulo (CTMSP) Sao Paulo, SP (Brazil)

    2011-07-01

    The environmental impact assessment of the Centro Experimental Aramar (CEA) facilities has been presented in a former work, based on the measured effluent releases data, for the period from 1995 to 2007. This work shows the update up to 2010. The effluents releases to the environment result from the routine operation of CEA nuclear fuel cycle facilities (LEI - Isotopic Enrichment Laboratory, USIDE - Pilot Plant for Industrial Verification of Uranium Enrichment and LABMAT - Nuclear Materials Laboratory). Basically, this work presents the radioactive release source terms, as described at the CEA Effluent Report sent to the National Commission for Nuclear Energy (CNEN) each semester, and a historical assessment of the critical group annual doses from 1995 up to 2010. The assessed doses are compared to the maximum dose constraint as well as to the exemption level specified by CNEN. (author)

  1. Chemistry of complexing molecules and environment. Report of the working group of the Cea ''mission environment''

    International Nuclear Information System (INIS)

    The Working group 'Chemistry of Complexing Molecules and Environment' of the Mission Environment (AG/ENV) identified themes for an original positioning of CEA on important issues of environmental research if a sufficiently strong demand appears. The research of CEA on the environment should be complementary to actions undertaken by other partners (official institutions, research organizations and industrial firms). The themes suggested are: the synthesis of new chelating molecules and new materials having specific properties, with the support of theoretical chemistry and modeling, analytical physical chemistry and speciation of species in relation to their eco-toxicity and their biogeochemical mobility in the natural environment. These themes, illustrated by examples of actions in progress at CEA or likely to be launched quickly, draw largely from recognized competences of the teams, generally developed for finalized nuclear applications: experimental, theoretical and instrumental competences. (author)

  2. Overview of CEA research in the field of radionuclides migration; Syntheses des recherches menees par le CEA sur la migration des radionucleides

    Energy Technology Data Exchange (ETDEWEB)

    Poinssot, Ch.; Trotignon, L.; Tevissen, E

    2006-07-01

    This report presents a synthetic status of the researches conducted within the Nuclear Energy Division (CEA/DEN) in the field of radionuclides migration in three specific areas which have been chosen for their representativeness and potential impact: the migration of RN in PWR reactors, the migration of RN from a deep geological repository and the migration processes in the surface environments. In addition, some status is given about more generic research which is conducted in the field of RN speciation in the aqueous phase and at the interfaces and regarding chemistry / transport couplings. Additional information about the human and technical means involved in these fields of research in CEA/DEN is finally given in the Appendix. (authors)

  3. Development of radiopharmaceuticals based on aptamers: selection and characterization of DNA aptamers for CEA

    Energy Technology Data Exchange (ETDEWEB)

    Correa, C.R.; Andrade, A.S.R., E-mail: antero@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Augusto-Pinto, L. [BioAptus, Belo Horizonte, MG (Brazil); Goes, A.M., E-mail: goes@icb.ufmg.br [Departamento de Imunologia e Bioquimica. Instituto de Ciencias Biologicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG (Brazil)

    2011-07-01

    Colorectal cancer is among the top four causes of cancer deaths worldwide. Carcinoembryonic antigen (CEA) is a complex intracellular glycoprotein produced by about 90% of colorectal cancers. CEA has been identified as an attractive target for cancer research because of its pattern of expression in the surface cell and its likely functional role in tumorigenesis. Research on the rapid selection of ligands based on the SELEX (systematic evolution of ligands by exponential enrichment) forms the basis for the development of high affinity and high specificity molecules, which can bind to surface determinants of tumour cells, like CEA. The oligonucleotides ligands generated in this technique are called aptamers. Aptamers can potentially find applications as therapeutic or diagnostic tools for many kind of diseases, like a tumor. Aptamers offer low immunogenicity, good tumour penetration, rapid uptake and fast systemic clearance, which favour their application as effective vehicles for radiotherapy. In addition aptamers can be labeled with different radioactive isotopes. The aim of this work was select aptamers binding to the CEA tumor marker. The aptamers are obtained through by SELEX, in which aptamers are selected from a library of random sequences of synthetic DNA by repetitive binding of the oligonucleotides to target molecule (CEA). Analyses of the secondary structure of the aptamers were determined using the m fold toll. Three aptamers were selected to binding assay with target cells. These aptamers were confirmed to have affinity and specific binding for T84 cell line (target cell), showed by confocal imaging. We are currently studying the potential efficacy of these aptamers as targeted radiopharmaceuticals, for use as imaging agents or therapeutic applications. The development of aptamers specific to CEA open new perspectives for colorectal cancer diagnosis and treatment. Acknowledgments: This investigation was supported by the Centro de Desenvolvimento da

  4. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa.

    Science.gov (United States)

    Muenzner, Petra; Kengmo Tchoupa, Arnaud; Klauser, Benedikt; Brunner, Thomas; Putze, Johannes; Dobrindt, Ulrich; Hauck, Christof R

    2016-05-01

    Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA) family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa) proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa. PMID:27171273

  5. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa.

    Directory of Open Access Journals (Sweden)

    Petra Muenzner

    2016-05-01

    Full Text Available Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa.

  6. Development of radiopharmaceuticals based on aptamers: selection and characterization of DNA aptamers for CEA

    International Nuclear Information System (INIS)

    Colorectal cancer is among the top four causes of cancer deaths worldwide. Carcinoembryonic antigen (CEA) is a complex intracellular glycoprotein produced by about 90% of colorectal cancers. CEA has been identified as an attractive target for cancer research because of its pattern of expression in the surface cell and its likely functional role in tumorigenesis. Research on the rapid selection of ligands based on the SELEX (systematic evolution of ligands by exponential enrichment) forms the basis for the development of high affinity and high specificity molecules, which can bind to surface determinants of tumour cells, like CEA. The oligonucleotides ligands generated in this technique are called aptamers. Aptamers can potentially find applications as therapeutic or diagnostic tools for many kind of diseases, like a tumor. Aptamers offer low immunogenicity, good tumour penetration, rapid uptake and fast systemic clearance, which favour their application as effective vehicles for radiotherapy. In addition aptamers can be labeled with different radioactive isotopes. The aim of this work was select aptamers binding to the CEA tumor marker. The aptamers are obtained through by SELEX, in which aptamers are selected from a library of random sequences of synthetic DNA by repetitive binding of the oligonucleotides to target molecule (CEA). Analyses of the secondary structure of the aptamers were determined using the m fold toll. Three aptamers were selected to binding assay with target cells. These aptamers were confirmed to have affinity and specific binding for T84 cell line (target cell), showed by confocal imaging. We are currently studying the potential efficacy of these aptamers as targeted radiopharmaceuticals, for use as imaging agents or therapeutic applications. The development of aptamers specific to CEA open new perspectives for colorectal cancer diagnosis and treatment. Acknowledgments: This investigation was supported by the Centro de Desenvolvimento da

  7. An Information Building on Radioactivity and Nuclear Energy for the French CEA Cadarache Research Center - 13492

    International Nuclear Information System (INIS)

    The CEA Cadarache research center is one of the 10 research centers of the French Alternative Energies and Atomic Energy Commission (CEA). Distributed throughout various research platforms, it focuses on nuclear fission, nuclear fusion, new energy technologies (hydrogen, solar, biomass) and fundamental research in the field of vegetal biology. It is the most important technological research and development centers for energy in Europe. Considering the sensitive nature of nuclear activities, the questions surrounding the issue of radioactive waste, the nuclear energy and the social, economic and environmental concerns for present and future generations, the French Government asked nuclear actors to open communication and to give all the information asked by the Local Information Commission (CLI) and the public [1]. In this context, the CEA Cadarache has decided to better show and explain its expertise and experience in the area of nuclear energy and nuclear power plant design, and to make it available to stakeholders and to the public. CEA Cadarache receives each year more than 9000 visitors. To complete technical visits of the research facilities and laboratories, a scientific cultural center has been built in 2011 to inform the public on CEA Cadarache research activities and to facilitate the acceptance of nuclear energy in a way suited to the level of knowledge of the visitors. A modern interactive exhibition of 150 m2 allows visitors to find out more about energy, CEA Cadarache research programs, radioactive waste management and radiological impact on the research center activities. It also offers an auditorium for group discussions and for school groups to discover science through enjoyment. This communication center has received several thousand visitors since its opening on October 2011; the initial results of this experience are now available. It's possible to explain the design of this exhibition, to give some statistics on the number of the visitors, their

  8. Prognostic value of monitoring tumour markers CA 15-3 and CEA during fulvestrant treatment

    International Nuclear Information System (INIS)

    At many centres tumour markers are used to detect disease recurrence and to monitor response to therapy in patients with advanced disease, although the real value of serial observation of marker levels remains disputed. In this study, we evaluated the prognostic value of tumour markers for predicting response (partial response [PR], stable disease [SD] ≥ 6 months), de novo disease progression (PD) and secondary PD in patients receiving fulvestrant ('Faslodex') 250 mg/month for the treatment of metastatic breast cancer (MBC). Changes in cancer antigen 15–3 (CA 15-3) and carcinoembryonic antigen (CEA) were prospectively monitored (monthly) and were also evaluated for the 3 months preceding secondary PD. Data from 67 patients with previously treated MBC participating in a Compassionate Use Programme were analysed. In patients with a PR (n = 7 [10.4%]), a non-significant increase in CA 15-3 occurred during the first 6 months of treatment; CEA was significantly reduced (P = 0.0165). In patients with SD ≥ 6 months (n = 28 [41.8%]), both CA 15-3 (P < 0.0001) and CEA (P = 0.0399) levels increased significantly after 6 months treatment. In those experiencing de novo PD (n = 32 [47.8%]), CA 15-3 increased significantly (P < 0.0001) after 4 months; CEA also increased significantly (P = 0.0002) during the same time period. Both CA 15-3 (P < 0.0001) and CEA (P < 0.0001) increased significantly in the 3 months preceding secondary PD. CA 15-3 increases in patients progressing on fulvestrant but may also increase in those experiencing clinical benefit; this should not be taken as a sign of PD without verification. Overall, both CA 15-3 and CEA appear to be poor prognostic markers for determining progression in patients receiving fulvestrant

  9. Report of transparency and nuclear safety 2007 CEA Fontenay aux Roses; Rapport transparence et securite nucleaire 2007 CEA Fontenay aux Roses

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Fontenay aux roses for the year 2007. After many years of decommissioning and dismantling of nuclear installations, the Center is now devoted (since 2005) to the development of research programmes on biology and biomedical technologies. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. (A.L.B.)

  10. Nuclear. In China, the CEA asserts itself as a team leader

    International Nuclear Information System (INIS)

    As the French government gave the CEA the responsibility of negotiating the nuclear French-Chinese nuclear strategic partnership, this article outlines the personality of the CEA's chairman, Bernard Bigot, but also the tensions which exist between the two main actors of the French nuclear industry, EDF and Areva, notably about their respective projects of development of a new reactor with China as far as EDF is concerned, and with Japan as far as Areva is concerned. In fact, China is asking France, not to build new reactors but to improve the performance and the safety in the existing ones

  11. Latest pixel size reduction of uncooled IR-FPA at CEA, LETI

    Science.gov (United States)

    Becker, Sebastien; Imperinetti, Pierre; Yon, Jean-Jacques; Ouvrier-Buffet, Jean-Louis; Goudon, Valérie; Hamelin, Antoine; Vialle, Claire; Arnaud, Agnès.

    2012-10-01

    Recent developments at the Infrared Lab (LIR) of CEA, LETI have been concentrated on the pixel size reduction of uncooled infrared detectors. With the support from French company ULIS, we have successfully demonstrated the technological integration of 12μm pixels on a commercial TV-format read-out circuit (VGA-ROIC) supplied by ULIS. The 12μm pixel has been designed, processed and characterized in CEA, LETI and first results showed exceptional performances. This paper presents the characterization and associated imagery results.

  12. The role of CA-242 and CEA in surveillance following curative resection for colorectal cancer.

    OpenAIRE

    Hall, N. R.; Finan, P. J.; Stephenson, B M; Purves, D. A.; Cooper, E H

    1994-01-01

    This study was undertaken to evaluate the role of a new tumour marker, CA-242, alone or in combination with CEA in the practical management of colorectal cancer patients after potentially curative resection. A cohort of 149 patients who had undergone 'curative' surgery was followed up according to an intensive protocol in order to detect recurrent disease. Over a median tumour marker follow-up period of 24 months there were 25 recurrences in 24 patients. Both CEA and CA-242 alone detected hal...

  13. The releases control and the environment survey of the Cea Centers

    International Nuclear Information System (INIS)

    The Cea sets the environment protection in the heart of its security policy, which is based on the mastership of risks resulting from the researches activities and installations development. This policy aims to reduce as small as possible compared with the technical and economical necessities, the impact of its activities on the human and the environment. This document, takes stock for the year 2002, of the liquid and gas radioactive effluents releases as also of the radioactivity level around the Cea Centers, by a systematic monitoring of the atmosphere, the waters, the vegetation and the milk. (A.L.B.)

  14. The CEA and the alternative energies. Press tour 25 and 26 november 1999

    International Nuclear Information System (INIS)

    In the framework of the public information on the CEA center of Cadarache and Grenoble, a presentation of the researches concerning the alternative energies is proposed. The Cea is commissioned by the Public Authorities, to keep the nuclear option open and for the long-dated, to develop renewable energies. In this domain researches on fuel cells and photovoltaic solar energy are performed. The principle and the applications of the fuel cell and the photovoltaic are recalled to introduce the research programs and the partners. (A.L.B.)

  15. 188Re-iorCEA1 as radioimmunotherapeutical agent: Preparation and evaluation. Cuba

    International Nuclear Information System (INIS)

    Effective immunotherapy of human malignancies requires the selective delivery of these agents to relevant antigen-expressing tumour cells. A variety of strategies have been investigated to achieve this objective. It has been very clearly established that ior-CEA1 monoclonal antibody is an extremely good agent for immunoscintigraphy with a high sensitivity (94%) and specificity (87%). Ior-CEA1 is hence a good candidate for development as a therapeutic agent. Moreover, it is an attractive novel protein, which conserves its biological properties, despite chemical treatment

  16. AMS/CEA Joint Aerial Campaign Nevada Test Site AMS Data Analysis Procedure

    International Nuclear Information System (INIS)

    The United States NNSA AMS (Aerial Measuring Systems) and the French Commissariat a l-Energie Atomique (CEA) participated in joint aerial survey activities during the period November 6-19, 2007. Survey activities were conducted near Las Vegas, Nevada, and at selected areas of the Nevada Test Site (NTS) under the auspices of the Accident Response Working Group (ARWG). The intent of the activities was to compare technologies, procedures, and data analysis techniques related to specific AMS and the CEA aerial radiation detection systems

  17. Changes in the legal status of the Commissariat a l'energie atomique (Cea)

    International Nuclear Information System (INIS)

    The Cea a public research institution was re-classified among the energy research establishments (11 december 2008). The Cea, as the result of exceptional circumstances and complex activities, is today entering into a new era and must confront many national and supranational challenges. It is preparing, in effect, for a future nuclear industry (safer, less polluting, non-proliferating and more economical) and is conducting research into other energy solutions within the framework of sustainable development and limited greenhouse gas effects (hydrogen technology, fusion, alternative energy technologies). It also has another goal, to make technological research available to industry, not only by developing micro and nano-technologies or even to contribute technology for the benefit of scientific knowledge of living creatures, matter, climate and the environment. The new classification of the Cea as a research establishment in the field of energy, a heading which includes three other entities (A.N.D.R.A., A.D.E.M.E. and I.F.P.), raises questions about its specialization and diversification. However, no substantive change was made to the drafting of the legislative provisions so it is possible to imagine that the Cea takes initiatives in other fields, at the instigation or with the approval of the government, a matter which is facilitated by its classification in the E.P.I.C. category (public establishment at industrial and commercial character). The Cea also represents France in international organisations in the nuclear sector, such as the OECD Nuclear energy agency (Nea), the International atomic energy agency (IAEA) and the European communities. It also participates in intergovernmental negotiations in the nuclear field and ensures any follow-up required with regard to any resulting agreements. today, the Cea plays a major role in the implementation of French nuclear policy with the aim of making available to countries wishing to develop nuclear energy, a framework

  18. Performances of Herschel/PACS bolometer arrays and future developments at CEA

    OpenAIRE

    Billot, N.; RODRIGUEZ, L.; Okumura, K; Sauvage, M.; Agnèse, P.

    2009-01-01

    The European Space Agency is building a space telescope to observe the Universe in the Far-IR and sub-millimeter regime of the electromagnetic spectrum. The scientific payload is composed of three instruments. One of them, PACS, is equipped with a novel type of bolometer arrays developed by CEA in the late 90's. We briefly present the PACS Photometer and the architecture of CEA filled bolometer arrays. We accessed the physics of the detectors and thoroughly measured their performances by deve...

  19. Assessment 2000 and regulation and method. Releases control and environmental survey of the CEA Centers; Bilan 2000 et reglementation et methode. Controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The environment quality around the CEA centers is a major interest of its safety policy. These documents contribute to the public information on the radioactive liquid and gaseous releases of the CEA, according to the ministry authorization. The radioactivity monitoring activity, and the survey methods are also presented. Data analysis from 1996 to 2000, allows to follow the evolution. (A.L.B.)

  20. Elaboration of an alpha-numeric classification for file of matters of the documentation service of the CEA

    International Nuclear Information System (INIS)

    We give the principles of a classification of matters to square basis, suiting the needs of the Service, of Documentation of the C.E.A. We present the detail of the categories in the order of the 'columns', likewise the big scientific subdivisions at the CEA. (authors)

  1. Combined effects of protein kinase inhibitors and 5-fluorouracil on CEA expression in human colon cancer cells.

    Science.gov (United States)

    Prete, Salvatore Pasquale; Rossi, Lorena; Correale, Pier Paolo; Turriziani, Mario; Baier, Susanne; Tamburrelli, Giuliana; De Vecchis, Liana; Bonmassar, Enzo; Aquino, Angelo

    2005-08-01

    Previous studies showed that 5-fluorouracil (5-FU) and Staurosporine (ST), a protein kinase inhibitor (PKI), were able to increase the expression of carcinoembryonic antigen (CEA) in human colon cancer cells. In the present study, we examined the in vitro effects of five PKIs, i.e. ST, 1-5-isoquinolinyl-sulfonyl-2-methylpiperazine (H-7), bisindolylmaleimide-I (BIS), Genistein (GEN), and Herbimycin A (HERB) alone or in combination with 5-FU on CEA expression. C22-20, a clonal subline, derived from colon cancer HT-29 line, selected for low expression of CEA, was used in our experimental model. Among the PKIs tested, only ST, at non-toxic concentrations of 5 nM, was capable of increasing the level of CEA. The other PKIs did not modify CEA expression when used either alone or in combination with 5-FU. Flow cytometric analysis showed that treatment of cells with 5-FU + ST resulted in a synergistic increase of CEA expression, being higher than that obtainable with both agents alone. Moreover, the increase of CEA expression occurred not only in membrane fractions but also in cytosolic compartments, as indicated by Western blot analysis. The present study suggests that ST-mediated induction of CEA expression in cancer cells is PKC independent and could be of potential clinical interest for the development of new diagnostic and/or immunotherapeutic approaches. PMID:15967383

  2. Clinical value of combined detection of serum CEA, CA15-3 and SF in lung cancer

    International Nuclear Information System (INIS)

    Objective: To investigate the clinical value of combined examination of serum CEA, CA15-3 and SF in lung cancer diagnosis. Methods: Serum concentrations of CEA, CA15-3 and SF were measured by chemiluminescent assay (CLA) in 99 patients with lung cancer and 25 patients with benign lung disease. Results: The positive rate of serum CEA, CA15-3 and SF in cases in lung cancer was 50.5%, 31.3% and 69.7%, respectively. Specificity of CEA, CA15-3 and SF measurements was 76%, 78% and 72%, respectively. In combined measurements, positive results of either two parameters revealed sensitivity and specificity of 82.8% and 92%, respectively. Conclusion: Combined measurements of CEA, CA15-3 and SF had evidently improved sensitivity and specificity in diagnosing lung cancer and thus were of good clinical value

  3. Combined determination of CEA, Fer, NSE and SCC levels in serum and chest effusion fluid for diagnosis of pulmonary cancer

    International Nuclear Information System (INIS)

    Objective: To study the clinical value of combined determination of CEA, Fer, NSE and SCC levels in serum and chest effusion fluid for dignosis of lung cancer. Methods: These four tumor markers were determined in serum and chest effusion fluid with RIA (NSE and SCC) or chemiluminescence method (CEA and Fer) in 52 patients with lung cancer, 48 patients with benign lung disease and 51 controls. Results: The serum and chest effusion fluid levels of CEA, Fer, NSE and SCC in patients with lung cancer were significantly higher than those in patients with benign lung diseases (all P<0.01) and 51 controls (P<0.001, <0.001, <0. 01 and <0.01 respectively). The positive rate of combined determination of CEA, Fer, NSE and SCC for lung cancer could be above 92.7%. Conclusion: Combined determination of CEA, Fer, NSE and SCC were a useful method for lung cancer diagnosis. (authors)

  4. Metastatic prostate cancer with elevated serum levels of CEA and CA19-9

    Directory of Open Access Journals (Sweden)

    Guang-Dar Juang

    2014-03-01

    Full Text Available Prostate-specific antigen (PSA is well known as a specific tumor marker for prostate cancer, but carcinoembryonic antigen (CEA- and carbohydrate antigen 19-9 (CA19-9-elevating adenocarcinomas originating in the prostate gland are rare. We report a case of metastatic adenocarcinoma of the prostate gland with a high serum level of CEA and CA19-9 in a 78-year-old man in whom prostate cancer (T3N1M1 had been diagnosed 2 years ago and who was treated with androgen deprivation therapy. He visited the emergency department because of a loss of appetite and abdominal pain. The serum CEA and CA19-9 levels were increased to 218.9 ng/mL (normal, <5 ng/mL and 212 ng/mL (normal, <27 ng/mL, respectively. The serum PSA level was slightly elevated (4.41 ng/mL. Computed tomography demonstrated multiple liver metastases, para-aortic lymph node enlargement, and lung metastases. A liver biopsy was performed and the specimen showed high-grade adenocarcinoma with focal positive staining for PSA. Despite chemotherapy with docetaxel, the patient died 3 months after treatment. Based on this case and a review of the literature, an aggressive variant of prostatic carcinoma with a high serum level of CEA and CA19-9 and a low PSA level was shown to progress rapidly with a poor prognosis.

  5. Solution recommended by the CEA to minimize fuel-cladding interaction problems

    International Nuclear Information System (INIS)

    To improve behavior of fuel elements under fast variation of power, the CEA developed a fracture resistant fuel: UO2 DCI and a cladding with low creep under irradiation: strong zircaloy 4. This paper gives main characteristics of these new materials and shows at what extent a better behavior of fuel pins is obtained concerning fuel-cladding interaction

  6. A study on the core analysis methodology for SMART CEA ejection accident-I

    International Nuclear Information System (INIS)

    A methodology to analyze the fuel enthalpy is developed based on MASTER that is a time dependent 3 dimensional core analysis code. Using the proposed methodology, SMART CEA ejection accident is analyzed. Moreover, radiation doses are estimated at the exclusion area boundary and low population zone to confirm the criteria for the accident. (Author). 31 refs., 13 tabs., 18 figs

  7. PZ Fiber Loss Measurements at LLNL and Plan to Confirm Results at CEA/Thomson

    CERN Document Server

    Bass, I L

    2000-01-01

    The objective of this paper is to confirm the slow-axis loss of less than 0.1 dB/m for the PZ fiber manufactured for LLNL by 3M and to provide samples of the fiber to CEA/Thomson that will permit them to readily verify this result.

  8. Situation 2002: release monitoring and surveillance of environment of Cea centers

    International Nuclear Information System (INIS)

    This publication renders an account of the situation of the releases of liquid and gaseous radioactive effluents, for the year 2002, as well as the radioactivity levels measured in the vicinity of Cea centers through the systematic surveillance of atmosphere, waters, vegetation and milk. An analysis on five years allows to follow their evolution. (N.C.)

  9. Plasma TIMP-1 and CEA as markers for detection of primary colorectal cancer

    DEFF Research Database (Denmark)

    Christensen, Ib Jarle; Brünner, Nils; Dowell, Barry;

    2015-01-01

    endoscopy were prospectively included (N=1965). Baseline data and co-morbidity were recorded. The primary end-point was the detection of CRC. Plasma was obtained before endoscopy and TIMP-1 and CEA levels were determined using an automated analysis platform when all samples were collected. RESULTS: CRC was...

  10. Experience gained at the CEA by thermal effluent utilization for agriculture and fish-breeding

    International Nuclear Information System (INIS)

    Results obtained at the CEA for waste heat utilization are examined. Water at T+100C is used for open air soil heating (forest, agriculture), eel breeding and greenhouse, heating (with the help of heat pumps). Water at T+230C or 300C is used for greenhouses. Facilities are described experience gained and results of the different exploitations are given

  11. Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas

    Science.gov (United States)

    Jogunoori, Wilma; Menon, Vipin; Majumdar, Avijit; Chen, Jiun-Sheng; Gi, Young Jin; Jeong, Yun Seong; Phan, Liem; Belkin, Mitchell; Gu, Shoujun; Kundra, Suchin; Mistry, Nipun A.; Zhang, Jianping; Su, Xiaoping; Li, Shulin; Lin, Sue-Hwa; Javle, Milind; McMurray, John S.; Rahlfs, Thomas F.; Mishra, Bibhuti; White, Jon; Rashid, Asif; Beauchemin, Nicole; Weston, Brian R.; Shafi, Mehnaz A.; Stroehlein, John R.; Davila, Marta; Akbani, Rehan; Weinstein, John N.; Wu, Xifeng; Mishra, Lopa

    2016-01-01

    Mutational processes and signatures that drive early tumorigenesis are centrally important for early cancer prevention. Yet, to date, biomarkers and risk factors for polyps (adenomas) that inordinately and rapidly develop into colon cancer remain poorly defined. Here, we describe surprisingly high mutational profiles through whole-genome sequence (WGS) analysis in 2 of 4 pairs of benign colorectal adenoma tissue samples. Unsupervised hierarchical clustered transcriptomic analysis of a further 7 pairs of adenomas reveals distinct mutational signatures regardless of adenoma size. Transitional single nucleotide substitutions of C:G>T:A predominate in the adenoma mutational spectrum. Strikingly, we observe mutations in the TGF-β pathway and CEA-associated genes in 4 out of 11 adenomas, overlapping with the Wnt pathway. Immunohistochemical labeling reveals a nearly 5-fold increase in CEA levels in 23% of adenoma samples with a concomitant loss of TGF-β signaling. We also define a functional role by which the CEA B3 domain interacts with TGFBR1, potentially inactivating the tumor suppressor function of TGF-β signaling. Our study uncovers diverse mutational processes underlying the transition from early adenoma to cancer. This has broad implications for biomarker-driven targeting of CEA/TGF-β in high-risk adenomas and may lead to early detection of aggressive adenoma to CRC progression. PMID:27100181

  12. The study of special killing effect of CD3AK on anti-CEA-positive tumor enhanced by DC loaded with CEA-rV%荷CEA-rV的DC增强CD3AK对CEA阳性肿瘤特异性杀伤作用的研究

    Institute of Scientific and Technical Information of China (English)

    祁岩超; 王新帅; 扬波

    2006-01-01

    Objective: To survey the special killing activity of CD3AK on anti-CEA-positive tumor enhanced by umbilical cord blood dendritic cell (DC) loaded with CEA recombinant vaccinia virus (CEA-rV). Methods: Freshly isolated umbilical blood mononuclear cells (UBMC) were cultivated for 3 h. Suspension cells and attached cells were used to induce CD3AK cells and DC separately. DC was loaded with CEA-rV on the 3rd day to prepare CEA-rV+DC. CD3AK cells were co-cultured with CEA-rV+DC on the 8th day, to prepare CEA-rV+DC+CD3AK. The killing activity of each effector's cell, which included UBMC, CD3AK, DC+CD3AK and CEA-rV+DC+CD3AK, was measured respectively by MTT reduction assay. Results: (1) 4 target cells were confirmed by CEA monoclonal antibody of rabbit anti-human. Lovo and A549 were really CEA positive cell lines, while Bel-7402 and K562 were CEA negative cell lines. (2) It was showed by flow-cytometry that the mature DC cultured at 10th day expressed MHCⅠ, Ⅱ molecules such as CD86, CD80, CD83 and CD40 highly, but CD123 lowly. The expression rates of CD86, CD80, CD83 and CD40 was 82.7%, 51.1%, 57.5% and 69.4%, respectively. The appearances and intra-cellular structures of DC were observed through light and electron microscope. The diameter of mature DC was 15-20 μm presented the irregular morphologic appearance, much prominences and pseudopodium. There were abundant mitochondria and endoplasmic reticulum in DC endochylema. (3) The rates of CD3, CD4, CD8 and CD28 in CD3AK cells group were 2 folds higher than that in UBMC group by FACS.It was said that the numbers of the mature T lymphocyte in CD3AK cells group were much greater than that in UBMC group. (4)The killing activities to 4 target cells of 3 effector's cells, which included CEA-rV+DC+CD3AK, DC+CD3AK and CD3AK, were much greater than that of UBMC (P<0.01). Moreover, comparing with the killing activities of 4 effector's: CEA-rV+DC+CD3AK group > DC+CD3AK group > CD3AK group > UBMC group. It showed that

  13. Dispersion of Radionuclides and Exposure Assessment in Urban Environments: A Joint CEA and LLNL Report

    Energy Technology Data Exchange (ETDEWEB)

    Glascoe, Lee [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gowardhan, Akshay [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lennox, Kristin [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Simpson, Matthew [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Yu, Kristen [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Armand, Patrick [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Duchenne, Christophe [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Mariotte, Frederic [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Pectorin, Xavier [Alternative Energies and Atomic Energy Commission (CEA), Paris (France)

    2014-12-19

    In the interest of promoting the international exchange of technical expertise, the US Department of Energy’s Office of Emergency Operations (NA-40) and the French Commissariat à l'Energie Atomique et aux énergies alternatives (CEA) requested that the National Atmospheric Release Advisory Center (NARAC) of Lawrence Livermore National Laboratory (LLNL) in Livermore, California host a joint table top exercise with experts in emergency management and atmospheric transport modeling. In this table top exercise, LLNL and CEA compared each other’s flow and dispersion models. The goal of the comparison is to facilitate the exchange of knowledge, capabilities, and practices, and to demonstrate the utility of modeling dispersal at different levels of computational fidelity. Two modeling approaches were examined, a regional scale modeling approach, appropriate for simple terrain and/or very large releases, and an urban scale modeling approach, appropriate for small releases in a city environment. This report is a summary of LLNL and CEA modeling efforts from this exercise. Two different types of LLNL and CEA models were employed in the analysis: urban-scale models (Aeolus CFD at LLNL/NARAC and Parallel- Micro-SWIFT-SPRAY, PMSS, at CEA) for analysis of a 5,000 Ci radiological release and Lagrangian Particle Dispersion Models (LODI at LLNL/NARAC and PSPRAY at CEA) for analysis of a much larger (500,000 Ci) regional radiological release. Two densely-populated urban locations were chosen: Chicago with its high-rise skyline and gridded street network and Paris with its more consistent, lower building height and complex unaligned street network. Each location was considered under early summer daytime and nighttime conditions. Different levels of fidelity were chosen for each scale: (1) lower fidelity mass-consistent diagnostic, intermediate fidelity Navier-Stokes RANS models, and higher fidelity Navier-Stokes LES for urban-scale analysis, and (2) lower-fidelity single

  14. Project: Decommissioning and Reuse of Licensed Nuclear Facilities at the CEA Centre, Fontenay-aux-Roses, (CEA-FAR) France. Annex A.I-3

    International Nuclear Information System (INIS)

    CEA-FAR is the CEA's oldest facility and is situated in the southern suburbs of Paris. It was opened on 26 March 1946 to host the first French atomic pile, which was named ZOE, and first went critical on 12 December 1946. The first laboratories were installed in existing buildings on the site. In the early 1950s, a number of nuclear facilities to be used for R and D work were built within the perimeter of the centre. This included the construction and operation of a pilot plant facility for the reprocessing of spent nuclear fuel. As space was restricted, all these installations were decommissioned and demolished to enable the construction of more modern second generation facilities. The Pu Pilot Plant for irradiated fuel reprocessing (the prototype of the Marcoule UP1 Plant) was used from 1953 to 1958. The dismantling of the equipment from the Pu Pilot Plant, the demolition of the buildings and the removal of the grounds to constitute a uniform platform were completed at the end of the 1950s. This operation made it possible to release the grounds on which building 18 was built, and also buildings 91 and 52. These buildings were constructed during the 1960s within the framework of the development of the CEN-FAR programmes. In the late 1950s and early 1960s, in addition to ZOE (NLF 11), which remained in service, the following second generation facilities were built: radio-metallurgy installations (NLF 58 and 59), radiochemistry and chemical engineering installations for the reprocessing of spent fuel (NLF 57), and installations for the treatment and interim storage of solid and liquid waste (NLF 34 and 73), which were required for pursuing the research programmes. These latter buildings are currently being cleaned up and dismantled. ZOE was closed down and partly dismantled in the 1970s to former IAEA Stage 2 and the research areas around the pile were transformed into a museum. The facilities shut down and dismantled in the 1980s were plutonium metallurgy

  15. Progress of the BT-EdF-CEA project. The lithium polymer battery; Avancees du projet BT-EdF-CEA. Batterie lithium polymere

    Energy Technology Data Exchange (ETDEWEB)

    Marginedes, D.; Majastre, H. [Bollore Technologies, 29 - Quimper (France); Baudry, P.; Lascaud, S. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches; Bloch, D.; Lebrun, N. [CEA Grenoble, CEREM, 38 (France)

    1996-12-31

    The lithium-polymer energy storage technology requires the production of thin films of huge surface. The BT-EdF-CEA consortium has studied the various manufacturing techniques of these films and their assembly. The process was chosen according to its productivity, low expensiveness, ecological impact and energy performances with capacities reaching 40 Ah. This paper explains: the objectives and specifications of the project, the advantage of the consortium and the role of the different partners, the results (coating, dry extrusion and battery element manufacturing techniques), and the electrochemical performances of the elements. (J.S.)

  16. Producing energy without greenhouse effect gases: the CEA action; Produire de l'energie sans gaz a effet de serre: l'action du CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    Major actor in the domain of new energy technologies, the CEA manages the french research on the hydrogen and the fuel cells. It is also implied with INES (National Institute for the Solar Energy) in the photovoltaic and thermal solar. With the IFP (French Petroleum Institute), it manages research on biofuels. Of course the thermonuclear fusion, for the development of the energy of the future, is in its research program too. This information document presents the possibilities of these energies and the associated research programs. (A.L.B.)

  17. The evaluation of the nuclear facilities safety at the CEA from 1999 to 2001; Le bilan de la surete des installations nucleaires du CEA du 1999 a 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    The aim of this document is the presentation of an evaluation of the problems and the safety methods in the concerned period. The first chapter presents the nuclear safety in the CEA. The second chapter is devoted to the organization and the quality for the safety: liabilities, audits, relations with the safety authorities and with the public. The chapters three and four deal respectively with the methodological and technical abilities supporting the exploitation teams and with the nuclear safety projects. The last chapter presents the experiments and events from 1999 to 2001. (A.L.B.)

  18. Continuously tritium monitoring of the pipe of liquid effluents at the Cea Cadarache; Controle en continu du tritium de la conduite des effluents liquides du CEA Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    Pira, Y

    2004-07-01

    This report is oriented toward the radiation protection of environment that is an essential component of radiation protection. It is necessary to detect any solid, liquid or gaseous abnormal release and to find its origin. The present study bears on a detection instrument in continuously to find tritium in liquid effluents of the Cea Cadarache. After having study the functioning principle of this device, an evaluation of its performances has been realised ( back noise, yield, detection limit) and to a checking in real conditions of utilization. (N.C.)

  19. Hookah smoking and cancer: carcinoembryonic antigen (CEA levels in exclusive/ever hookah smokers

    Directory of Open Access Journals (Sweden)

    Chaouachi Kamal

    2008-05-01

    Full Text Available Abstract Background We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (cigarettes, bidis, etc.. Objectives To find serum CEA levels in ever/exclusive hookah smokers, i.e. those who smoked only hookah (no cigarettes, bidis, etc., prepared between 1 and 4 times a day with a quantity of up to 120 g of a tobacco-molasses mixture each (i.e. the tobacco weight equivalent of up to 60 cigarettes of 1 g each and consumed in 1 to 8 sessions. Methods Enhanced chemiluminescent immunometric technique was applied to measure CEA levels in serum samples from 59 exclusive male smokers with age ranging from 20–80 years (mean = 58.8 ± 14.7 years and 8–65 years of smoking (mean = 37.7 ± 16.8. 36 non-smokers served as controls. Subjects were divided into 3 groups according to the number of preparations; the number of sessions and the total daily smoking time: Light (1; 1; ≤ 20 minutes; Medium (1–3; 1–3; >20 min to ≤ 2 hrs and Heavy smokers (2–4; 3–8; >2 hrs to ≤ 6 hrs. Because of the nature of distribution of CEA levels among our individuals, Wilcoxon's rank sum two-sample test was applied to compare the variables. Results The overall CEA levels in exclusive hookah smokers (mean: 3.58 ± 2.61 ng/ml; n = 59 were not significantly different (p ≤ 0.0937 from the levels in non-smokers (2.35 ± 0.71 ng/ml. Mean levels in light, medium and heavy smokers were: 1.06 ± 0.492 ng/ml (n = 5; 2.52 ± 1.15 ng/ml (n = 28 and 5.11 ± 3.08 ng/ml (n = 26 respectively. The levels in medium smokers and non-smokers were also not significantly different (p ≤ 0.9138. In heavy smokers, the CEA levels were significantly higher than in non-smokers (p ≤ 0.0001567. Conclusion Overall CEA levels in exclusive hookah

  20. CEA serum level as early predictive marker of outcome during EGFR-TKI therapy in advanced NSCLC patients.

    Science.gov (United States)

    Facchinetti, Francesco; Aldigeri, Raffaella; Aloe, Rosalia; Bortesi, Beatrice; Ardizzoni, Andrea; Tiseo, Marcello

    2015-08-01

    Considering the role of carcinoembryonic antigen (CEA) serum levels as potential useful predictive marker during chemotherapy treatment, we studied its applicability in advanced non-small cell lung cancer (NSCLC) patients treated with epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs). Our retrospective cohort consists of 79 patients (33 EGFR mutated and 46 EGFR wild type or unknown) affected by advanced NSCLC, for whom CEA serum values at the beginning of TKI therapy and after the first month of treatment were available, regardless of treatment line. Baseline CEA value, percentage of CEA reduction after 1 month, and percentage of patients with ≥20 % CEA decrease after 1 month (CEA response) were correlated with disease control rate (DCR), progression-free (PFS), and overall (OS) survival, according to EGFR mutational status. Median baseline CEA levels were significantly higher in EGFR mutated (40.9 ng/ml; interquartile range (IQR) 8.9-197.6) than in wild-type cases (6.2 ng/ml; IQR 2.8-12.8; p = 0.003). Both percentage reduction in CEA levels (-10.7 vs. +13.4 %) and percentage of cases with CEA response (42 vs. 20 %) were significantly higher in mutated vs. wild-type/unknown patients (p = 0.007 and p = 0.027, respectively). In wild-type/unknown patients, CEA response was significantly correlated with DCR (p = 0.001) and resulted as a significant predictor of PFS both in univariate (p = 0.002) and in multivariate analyses (hazard ratio (HR) 0.27; 95 % confidence interval (CI) 0.11-0.66; p = 0.004); only a trend was found for OS prediction (p = 0.082). In EGFR-mutated group, CEA reduction did not show any correlation either with PFS or OS. CEA response after 1 month of EGFR-TKI therapy could be a useful marker, worthy to further studies, as early predictor of treatment outcome in EGFR wild-type/unknown unselected NSCLC cases for which no molecular predictor is yet available. PMID:25731731

  1. Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: from the Danish 'MALOVA'ovarian cancer study

    DEFF Research Database (Denmark)

    Hogdall, E.V.; Christensen, L.; Blaakaer, J.; Jarle, Christensen,I; Gayther, S.; Jacobs, I.J.; Hogdall, C.K.; Kjær, Susanne Krüger

    2008-01-01

    from 189 women diagnosed with low malignant potential ovarian tumours (LMP, borderline ovarian tumours) and 571 women diagnosed with ovarian cancer (OC). RESULTS: Using 30% as the cut-off level for CEA over-expression, 18% of LMPs and 4% of OCs were positive. A higher proportion of mucinous tumours......AIMS: To determine the variation in expression of carcinoembryonic antigen (CEA) in 760 epithelial ovarian tumours from Denmark, and to correlate expression with clinicopathological parameters and prognosis for the disease. METHODS: Using tissue arrays (TA), we analysed CEA expression in tissues...

  2. Fusion technology. Annual report of the Association CEA/EURATOM 1997

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le Vagueres, F

    1998-12-31

    The research and development work performed by the French EURATOM-CEA Association for fusion technology is part of the Fusion Programme of the European Community. This report compiles the work carried out during the year 1997 as follows: The ITER CEA activities and related developments are described in the first section (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); The second part is dedicated to the Long Term activities as Blankets and material developments, long term safety, socio-economic problem; The Underlying Technology activities are compiled in the third part of this report (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); And the fourth part describes the inertial confinement studies. (K.A.)

  3. Diatomácea marinha Coscinodiscus wailesii Gran et Angst(BACILLARIOPHYCEAE)

    OpenAIRE

    Ascencio, Poliana G. Marson

    2012-01-01

    A diatomácea marinha cêntrica Coscinodiscus wailesii Gran et Angst, considerada uma espécie nociva, vem despertando grande interesse ecológico. Suas florações, vêm prejudicando áreas de pesca e cultivo em diferentes regiões do mundo. Entretanto essa microalga marinha é muito pouco estudada em relação ao seu crescimento celular, composição química, produção e caracterização de polissacarídeos e ácidos graxos. Sendo assim, nesse trabalho foi realizado o isolamento e o cultivo da diatomácea C. w...

  4. The French 'CEA 86' multigroup cross-section library and its integral qualification

    International Nuclear Information System (INIS)

    This paper describe the up-dated 99 groups library of the APOLLO French neutron computer code, the denominated 'CEA 86' library. The multigroup cross-section sets are based on the more recent nuclear data evaluations. The THEMIS code was generally used for the JEF-1 processing. In order to account for recent differential measurements and to improve the consistency between calculation and integral experiments, we produced our own CEA evaluations for the actinide nuclides: 235U, 238U, 239Pu, 240Pu, 241Am. This new APOLLO library was checked against critical experiments and PWR measurements: computed Conversion Factor, Reactivity Coefficients, Multiplication Factor, and Pu build-up are now in good agreement with LWR experimental results. PWR Pu recycling calculations, as does as HCLWR design studies, are also significantly improved. (author)

  5. 2004 annual report. Defense, safety, energy, information, health. CEA in the center of big European challenges

    International Nuclear Information System (INIS)

    This document is the 2004 annual report of the French atomic energy commission (CEA). It presents the R and D activities of the CEA in three main domains: 1 - defense and safety, maintaining perenniality of nuclear dissuasion and nuclear safety: supplying nuclear weapons to armies, maintaining dissuasion capability with the simulation program, sharing R and D means with the scientific community and the industrial world, designing and maintaining naval nuclear propulsion reactors, cleansing Marcoule and Pierrelatte facilities, monitoring treaties and fighting against proliferation and terrorism; 2 - energy, developing more competitive and cleaner energy sources: nuclear waste management, optimization of industrial nuclear activities, future nuclear systems and new energy technologies, basic research on energy, radiobiology and toxicology; 3 - information and health, valorizing industry thanks to technological research and supplying new tools for health and medical research: micro- and nano-technologies, software technologies, basic research for industrial innovation, nuclear technologies for health and bio-technologies. (J.S.)

  6. Cancer mortality of nuclear workers of CEA and COGEMA from 1969 to 1986

    International Nuclear Information System (INIS)

    Cancer mortality of the nuclear workers of CEA and COGEMA has been collected by the occupational health services of both firms from 1969 to 1986. The data are related only to the workers who died when in activity. Only very few workers left CEA and COGEMA before retirement so we consider this mortality survey as describing correctly the cancer mortality for the age groups less than 60-65 years old. Compared to the national mortality of same sex, age and calendar period, by the method of indirect standardization, the only excess observed was in the female population, linked to breast cancer mortality. The male population demonstrated a high healthy worker effect, even for cancer mortality. This study has now to be completed by an typical epidemiological cohort study in order to test cancer mortality after retirement and to discuss a possible relation with occupational exposure. (author)

  7. The role of the CEA in the first steps of neutronics

    International Nuclear Information System (INIS)

    A historical review of the early developments of neutronics and nuclear energy experimentations in France since World War II, with the creation of the CEA in 1945: neutronics theory investigations through the works of some leading french physicists, giving rise to the calculations of the first French heavy water reactor Zoe and its numerous experimentations, the theoretical works on mathematical physics in the fifties and sixties: spherical harmonics decompositions, double spherical harmonics method, calculations of the effect of cavities and cooling ducts on diffusion coefficient and reactivity, the development of models for phenomenon description. The various ways of knowledge and information dissemination involving the CEA at that time are presented, leading to the creation in 1956 of the INSTN nuclear techniques and sciences institute

  8. R and D developments on the disposal of radioactive wastes recently carried out at CEA (France)

    International Nuclear Information System (INIS)

    Since the law of december 31, 1991 voted by the French Parliament, disposal in geological formations is not the sole option considered for the management of radioactive wastes. Scientists and engineers, notably within the 'Commissariat a l'Energie Atomique' (CEA), must investigate in parallel two other options, namely i. advanced separation of long-lived radioisotopes and transmutation, and ii. improvement of radioactive waste matrices and long-term storage. Still, the geological disposal of radioactive wastes, which has generated within the last decade an immense amount of Research and Development, remains a major proposed solution to the long-term management of transuranic and high-level wastes. In this paper, we will describe some of the Research and Development carried out within CEA, avoiding the industrial and engineering aspects of the issues dealt with. Rather, we will illustrate major points of our basic research, underlining in particular methodological considerations

  9. Technetium-99m labelling of the IOR CEA 1 monoclonal antibody: evaluation of different methods

    Energy Technology Data Exchange (ETDEWEB)

    Gano, L.; Fernandes, C.; Patricio, L. [Inst. Tecnologico Nuclear, Sacavem (Portugal); Cantinho, G.; Santos, A.I.; Pena, H. [F.M.L., Lisboa (Portugal). Inst. Medicina Nuclear; Vieira, R.; Salgado, L. [IPOFG, Lisboa (Portugal). Servico Medicina Nuclear

    1997-09-01

    Aim: The aim of this study was to investigate the in vivo and in vitro properties of {sup 99m}Tc labelled monoclonal antibody, IOR CEA 1 when radiolabelled by different methods. Methods: To achieve that purpose IOR CEA was directly radiolabelled via 2-mercaptoethanol (2-Me) and stannous ion (SnCl{sub 2}) reduction and indirectly via the 2-iminothiolane (2-Im) conjugation. The resulting {sup 99m}Tc-MoAbs were analysed for number of free sulfhydryl groups, chemical and radiochemical purity (checked by HPLC and SDS PAGE), immunoreactivity and biological distribution in mice. Results: Experimental results indicated a similar radiochemical purity and immunoreactivity for direct labelling methods and a decrease of both for 2-Im method. 2-Me antibody reduction led to a high antibody fragmentation as indicated by non-denaturing SDS PAGE analysis. Nevertheless SnCl{sub 2} and 2-Im labels revealed lower in vivo stability. Conclusion: {sup 99m}Tc-(2-Me) IOR CEA presented favourable in vitro and in vivo properties. Therefore this label was compared to {sup 99m}Tc-monoclonal antibody BW 431/26. Similar characteristics were found. Clinical studies also revealed identical biodistribution profile. (orig.) [Deutsch] Ziel: Ziel der vorliegenden Studie war die Untersuchung der in vitro und in vivo Eigenschaften Technetium-markierter monoklonaler Antikoerper. Methoden: Hierzu wurde IOR CEA 1 entweder direkt, nach Reduktion mit 2-Mercaptoethanol (2-Me) bzw. Zinn(II)chlorid (SnCl{sub 2}), oder indirekt nach Konjugation mit 2-Iminothiolan (2-Im) markiert. Die Integritaet des reduzierten bzw. konjugierten Antikoerpers wurde mittels Bindungsassays und Elektrophorese ermittelt. Die radiochemischen Ausbeuten bzw. Reinheiten wurden chromatographisch bestimmt. Die pharmakokinetischen Eigenschaften von {sup 99m}Tc-IOR CEA 1 wurden tierexperimentell im Vergleich zu {sup 99m}Tc-BW 431/26 ermittelt. In einer ersten Studie wurden {sup 99m}Tc-(2-Me-)IOR CEA 1 und {sup 99m}Tc-BW 431/26 verglichen

  10. Corium behaviour research at CEA Cadarache. The PLINIUS prototypic corium experimental platform

    International Nuclear Information System (INIS)

    In the hypothetical case of a Light Water Reactor severe accident, the reactor core could melt and form with structure materials, and eventually concrete, a complex mixture called corium. The knowledge of corium behaviour is one of the key to increase the safety of the nuclear reactors. In the framework of severe accident studies, CEA has undertaken for many years a large RandD program devoted to this topic. At CEA-Cadarache, a specific platform, called PLINIUS, has been developed and is dedicated to studies of prototypic corium (i.e. with uranium dioxide). In this paper, the PLINIUS platform four facilities and the experiments on corium behaviour are described.(author)

  11. Fusion technology. Annual report of the Association CEA/EURATOM 1997

    International Nuclear Information System (INIS)

    The research and development work performed by the French EURATOM-CEA Association for fusion technology is part of the Fusion Programme of the European Community. This report compiles the work carried out during the year 1997 as follows: The ITER CEA activities and related developments are described in the first section (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); The second part is dedicated to the Long Term activities as Blankets and material developments, long term safety, socio-economic problem; The Underlying Technology activities are compiled in the third part of this report (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); And the fourth part describes the inertial confinement studies. (K.A.)

  12. Report of transparency and nuclear safety 2007 CEA Fontenay aux Roses

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Fontenay aux roses for the year 2007. After many years of decommissioning and dismantling of nuclear installations, the Center is now devoted (since 2005) to the development of research programmes on biology and biomedical technologies. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. (A.L.B.)

  13. EURATOM-CEA association contributions to the 21st symposium on fusion technology

    International Nuclear Information System (INIS)

    The 27 contributions of EURATOM-Cea association have been gathered with 6 additional papers and 1 invited paper in this document. Most papers concern Tore-Supra and deal with the ergodic divertor, particle injection, impedance concept for ICRF antennas, low hybrid current drive, RF systems, the 118 GHz ECRH experiment, the inner first wall, improved vacuum vessel protection, pellet injection, material activation, and the CIEL project. 3 of the additional papers concern the model coil of ITER

  14. Integral experiments performed at CEA to improve the Pu higher isotope nuclear data: PLUTO programme

    International Nuclear Information System (INIS)

    The characteristics and main results of the experimental program PLUTO, developed at CEA to improve the Pu higher isotope nuclear data, are presented. The integral experiments performed aim at providing the information necessary to adjust the multigroup cross sections used for the design calculations. The comparison of the calculation to experiment deviations on the integral parameters before and after the cross-section adjustment show the improvement brought by the PLUTO program. 6 figures, 10 tables

  15. Estructura factorial y fiabilidad de un cuestionario de estrategias de aprendizaje en universitarios: CEA-U

    OpenAIRE

    Martín Cabrera, Eduardo; García García, Luis Alberto; Torbay Betancor, Ángela; Rodríguez Blanco, Teresa

    2007-01-01

    Se analiza la estructura factorial y la consistencia interna del Cuestionario de Estrategias de Aprendizaje en Universitarios (CEA-U) a partir de las respuestas de 1105 estudiantes de segundo ciclo de carrera universitaria,. El cuestionario está formado por tres escalas: estrategias motivacionales, cognitivas y metacognitivas, en las que el análisis factorial exploratorio arroja once factores empíricos. En un análisis factorial de segundo orden, los once factores se agrupan en tres macrofacto...

  16. Differentialdiagnose beim Lungenkarzinom durch CEA, CYFRA 21-1, NSE und ProGRP

    OpenAIRE

    Gruber, Christine

    2008-01-01

    Es handelt sich um eine bizentrische, retrospektive Studie am Institut für Klinische Chemie am Klinikum Großhadern, München und an der Asklepioslungenfachklinik Gauting. Anhand von insgesamt 2749 Patienten wurde univariat und multivariat analysiert, inwieweit die Tumormarker CEA, CYFRA 21-1, NSE und ProGRP und zusätzlich die Routinelaborparameter eine Hilfestellung sowohl in der Diagnostik und Differentialdiagnostik eines Lungenrundherdes (benigne Lungenerkrankung, primäres Lungenkarzinom, Lu...

  17. Evaluation 2000 and regulation and method. Release monitoring and environmental surveillance around Cea centers

    International Nuclear Information System (INIS)

    This publication counts for the year 2000 for the evaluation of liquid and gaseous radioactive effluents releases and the radioactivity levels measured in the vicinity of Cea centers, through the air, water, vegetation and milk surveillance. An analysis of the results from 1996 to 2000 allows to follow their evolution. A second booklet develops the sampling and measurement methods made on effluents in environment. It present besides the regulation applied to effluents monitoring. (N.C.)

  18. EURATOM-CEA association contributions to the 21st symposium on fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Garin, P.; Grosman, A.; Beaumont, B. [and others

    2000-11-01

    The 27 contributions of EURATOM-Cea association have been gathered with 6 additional papers and 1 invited paper in this document. Most papers concern Tore-Supra and deal with the ergodic divertor, particle injection, impedance concept for ICRF antennas, low hybrid current drive, RF systems, the 118 GHz ECRH experiment, the inner first wall, improved vacuum vessel protection, pellet injection, material activation, and the CIEL project. 3 of the additional papers concern the model coil of ITER.

  19. Insights into the economic viability of a new CEA system producing hydroponic lettuce

    OpenAIRE

    Ilaslan, Gunes; White, Gerald B.; Langhans, Robert W.

    2002-01-01

    A new CEA (Controlled Environment Agriculture) system growing Boston lettuce, Lactuca Sativa cv. ‘Vivaldi’, achieves the same quality and quantity of production every day of the year. The year-round constant quantity and quality production indicate potential for success. However, our research showed that out of nine selected U.S. locations with different climatic and economic conditions, the Northeast had 25.7 percent higher production costs for the same yield. The analysis indicated that giv...

  20. Aeroacoustics research in Europe: The CEAS-ASC report on 2013 highlights

    Science.gov (United States)

    Bennett, G. J.; Kennedy, J.; Meskell, C.; Carley, M.; Jordan, P.; Rice, H.

    2015-03-01

    The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, "aeroacoustics" encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe. This paper is a report on highlights of aeroacoustics research in Europe in 2013, compiled from information provided to the ASC of the CEAS. During 2013, a number of research programmes involving aeroacoustics were funded by the European Commission. Some of the highlights from these programmes are summarised in this paper, as well as highlights from other programmes funded by national programmes or by industry. Furthermore, a concise summary of the CEAS-ASC workshop "Atmospheric and Ground Effects on Aircraft Noise" held in Seville, Spain in September 2013 is included in this report. Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection. This issue of the "highlights" paper is dedicated to the memory of Prof. John A. Fitzpatrick, Professor of Mechanical Engineering, Trinity College Dublin, and a valued member of the Aeroacoustics Specialists Committee. John passed away in September 2012 and is fondly missed across the globe by the friends he made in the Aeroacoustics Community. This paper is edited by PhD graduates and colleagues of John's who conduct research in aeroacoustics, inspired by his thirst for knowledge.

  1. Cea strategy in the field of simulation and high-performance computing

    International Nuclear Information System (INIS)

    The full text of the publication follows. Modelling and Simulation are at the heart of research and development activities carried out by Cea. Modelling relies not only on the most advanced theories and on phenomenological experiments that ensured their tuning, but also on more instrumented experiments that deliver both the useful data for the implementation of these models and the elements required for their validation. Simulation not only covers an as close as possible representation of the physical reality, but more generally all numerical experimentation carried out with any model. In particular, there are scientific problems that cannot be solved by simulation alone. Cea makes use of simulation for understanding, for design, and for taking actions. Particle physics, climatology, the analysis and comparison of genomic sequences, the study of dynamics and folding of proteins, material physics or high temperature plasma physics illustrate the theme of simulation 'for understanding'. Designing fission or fusion reactors of the future, or nuclear weapons may use of simulation for design. Real-time simulators that aim at training operators of nuclear power plants, as well as simulations carried out to prove nuclear safety, belong to the third category. Technological evolution in the field of computers, software, or algorithms, or more generally progress made in the field of modelling have enabled Cea and others to advance significantly in regard to simulation. The hierarchization of models and multi-scale simulation techniques permit in fact the use of results stemming from milli-metric, micro-metric or even nano-metric level simulations for models that are representative of the system at the metric level. The same is true for time-scales. The rendering common place of workstations or PC-cluster based department servers, readily offering a performance of the order of a Giga-flop or tens of Giga-flops, makes it possible to meet the large majority of Cea needs. The

  2. Technetium-99m labelling of the IOR CEA 1 monoclonal antibody: evaluation of different methods

    International Nuclear Information System (INIS)

    Aim: The aim of this study was to investigate the in vivo and in vitro properties of 99mTc labelled monoclonal antibody, IOR CEA 1 when radiolabelled by different methods. Methods: To achieve that purpose IOR CEA was directly radiolabelled via 2-mercaptoethanol (2-Me) and stannous ion (SnCl2) reduction and indirectly via the 2-iminothiolane (2-Im) conjugation. The resulting 99mTc-MoAbs were analysed for number of free sulfhydryl groups, chemical and radiochemical purity (checked by HPLC and SDS PAGE), immunoreactivity and biological distribution in mice. Results: Experimental results indicated a similar radiochemical purity and immunoreactivity for direct labelling methods and a decrease of both for 2-Im method. 2-Me antibody reduction led to a high antibody fragmentation as indicated by non-denaturing SDS PAGE analysis. Nevertheless SnCl2 and 2-Im labels revealed lower in vivo stability. Conclusion: 99mTc-(2-Me) IOR CEA presented favourable in vitro and in vivo properties. Therefore this label was compared to 99mTc-monoclonal antibody BW 431/26. Similar characteristics were found. Clinical studies also revealed identical biodistribution profile. (orig.)

  3. Radioimmunoimaging of ovarian cancer with 131I labelled CEA monoclonal antibody

    International Nuclear Information System (INIS)

    Objective: To investigate radioimmunoimaging with 131I labelled CEA McAb and its value in diagnosis and treatment of ovarian cancer. Methods: CEA McAb was labelled with 131I by standard chloramine T procedure. The radiolabeled McAb was given intravenously to the patients. The scintigraphy was performed at different time. Results: In 105 patients with histopathology proved ovarian cancers, for 96 patients the lesions were well located with RII (true positives), for the remaining 9 patients, the results were false negative. 22/23 cases with RII diagnosed benign ovarian tumors were proved to be true negative by surgical pathology in RII. Of 96 ovarian cancers 87 were stratified into identical stages by surgical pathology all RII. 141/151 metastatic tumors were found in RII and the positive rate was as high as 93.4%. The smallest tumor defected by RII was of 1 cm in diameter. Conclusions: RII is as good as ultrasonography and CT in distinguishing benignancy and malignancy. The location, size and number of the lesions can also be determined with RII. RII of ovarian cancer with 131I-CEA McAb is valuable and helpful in early detection of ovarian cancer. It is also helpful for clinical staging, treatment programing and prognosticating

  4. Annual report of the Association EURATOM-Cea 2005 (full report)

    International Nuclear Information System (INIS)

    This annual report summarizes activities performed by the EURATOM-Cea association in 2005. The activities carried out in the field 'physics integration' are mainly linked to the ion cyclotron range of frequency antenna development and to the development of diagnostic components. The vacuum vessel studies have mainly focused at welding techniques and at qualification of inspection methods along the vacuum vessel inter-sector weld. On the plasma facing component side investigations have been performed on material knowledge (CuCrZr creep-fatigue studies, neutron effects on material properties of CFC, development and optimisation of Be/CuCrZr joining techniques and studies dedicated to the divertor. In the field 'magnets', EURATOM-Cea association has devoted a major part of its effort to the studies of advanced Nb3Sn strands for the toroidal field coil, and the first full size conductor sample was manufactured. Within the frame of Test Blanket Module (TBM), activities mainly concerned the improvement and completion of the TBM engineering design. Within the frame of the Helium Cooled Pebble Bed concept programmes, studies about the development of Li2TiO3 pebbles are on going. The main objective of 2005 which was to improve the shape of Li2TiO3 pebbles has been successfully achieved. EURATOM-Cea maintained significant involvement in the development of structural materials for a fusion reactor. A strong effort has been made on a program of laser detritiation associated with remote handling. (A.C.)

  5. 188Re-IorCEA1 as radioimmunotherapeutical agent: Preparation and evaluation

    International Nuclear Information System (INIS)

    Effective immunotherapy of human malignancies requires the selective delivery of these agents to relevant antigen-expressing tumour cells. A variety of strategies have been investigated to achieve this objective. It has very clearly established that ior-CEA1 monoclonal antibody is an extremely good agent for immunoscintigraphy with a high sensitivity (94%) and specificity (87%) (OLIVA 94, OLIVA 95). Ior-CEA1 is hence a good candidate for development as a therapeutic agent. Moreover, it is an attractive novel protein, which conserves its biological properties, despite chemical treatment. Radiolabelling of ior-CEA1 is accomplished by a direct method using 2-mercaptoethanol as the reducing agent. Two different weak chelating agents were employed, which had been reported in other published works before. All experiments carried out with MDP showed low labelling yields and high precipitate formation, even while SnF2, which has better redox properties. The best labelling yields were attained with low citric acid concentration, as well as with 400 μg of SnF2 at pH 3. The optimised method gave high labelling yields (∼ 95 %). The best labelling yields were attained with low citric acid concentration, which was used as a weak transchelation ligand. Ascorbic acid and Albumin could be used as the stabilising agents in order to achieve less than 3,5% dissociation

  6. Value of human chorionic gonadotropin compared to CEA in discriminating benign from malignant effusions.

    Science.gov (United States)

    Lamerz, R; Stoetzer, O J; Mezger, J; Brandt, A; Darsow, M; Wilmanns, W

    1999-01-01

    Human chorionic gonadotropin (HCG) is expressed in germ cell tumors and urothelial, breast, lung and colon cancers. The aim of the study was to investigate if the determination of HCG in comparison with CEA is able to discriminate between malignant and benign effusions. Effusion and partially serum samples of 61 patients with benign (g.i., heart/kidney isnuff.) and 116 patients with malignant diseases (g.i., gynec., lung, misc., CUP) were investigated. HCG was specifically determined by an IRMA using 2 monoclonal antibodies, CEA by a conventional double Ab RIA. Cytological staining was preformed using the Pappenheim-method on cytospin preparations. Significant differences (p gynec. (32.1%) gynec. (60%) pleural effusions with high specificity (90% at 5 IU/l) but low sensitivity of 31% increasing in g.i., lung and gynecologic cases, CEA a more general TM with higher sensitivity of 45% increasing in g.i., gynecologic and lung cases (sp. 100% at 9 ng/ml) both adding significantly to cytology-negative effusions. PMID:10470169

  7. FDG-PET scan in patients with clinically and/or radiologically suspicious colorectal cancer recurrence but normal CEA

    OpenAIRE

    Zhang Jun; Povoski Stephen P; Bloomston Mark; Sarikaya Ismet; Hall Nathan C; Knopp Michael V; Martin Edward W

    2007-01-01

    Abstract Background Although frequently used for tumor surveillance, the sensitivity of carcinoembryonic antigen (CEA) to detect recurrent colorectal cancer (CRC) is not optimal. Fluorine 18-fluoro-2-deoxy-glucose-positron emission tomography (18F FDG-PET) scans promise to improve recurrent CRC detection. We aimed to review PET scans of patients with clinically and/or radiologically suspicious tumor recurrence but normal CEA. Methods A retrospective review of an electronic database of 308 pat...

  8. Detection of hTERT mRNA, CEA, CA19-9 in Pleural Effusion and Its Clinical Significance

    Institute of Scientific and Technical Information of China (English)

    Niangui Zhao; Xiaoqun Ye; Weilan Yang; Yeqing Zou; Chunsong Yan

    2008-01-01

    OBJECTIVE To explore the clinical significance of the human telomerase reverse transcriptase (hTERT) mRNA, CEA and CA19-9 in differential diagnosis of benign and malignant pleural effusions.METHODS Concentrations of CEA and CA19-9 in pleural effusions were assayed using automated chemiluminescence, and expression of hTERT mRNA was detected by RT-PCR.RESULTS The positive rates of hTERT mRNA, CEA and CA19-9 expression in the group with malignant effusions were significantly higher compared to the group with benign effusion(P < 0.05). The sensitivity (%), specificity (%) and diagnostic accordance rates (%) of the 3 tumor markers were as follows: I)hTERT mRNA: 81.8/90.5/86.1; ii) CEA: 52.3/92.9/72.1; iii) CA19-9:34.1/90.5/61.6. The positive rates of hTERT mRNA + CEA (%)expression in the pleural effusions were 97.7.CONCLUSION All of these tumor markers can be helpful for differential diagnosis of pleural effusions, hTERT mRNA had more clinical value in differentiation of the pleural efffusions.CA19-9 is unfit to be as an optimal index. The combined assay of hTERT mRNA and CEA in pleural effusions can further raise the positive detection rate of the tumor markers and can be helpful in producing a diagnosis.

  9. Lithium/polymer batteries. Safety approach of the BT-EDF-CEA project; Accumulateurs lithium/polymere. Demarche securite du projet BT-EDF-CEA

    Energy Technology Data Exchange (ETDEWEB)

    Lascaud, S.; Baudry, P. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches; Majastre, H. [Bollore Technologies, 29 - Quimper (France); Bloch, D. [CEAGrenoble, CEREM, 38 (France)

    1996-12-31

    The BT-EdF-CEA consortium for the development and the performance improvement of lithium/polymer batteries has carried out a safety analysis of the industrial risk and the risk for users linked with this new technology. The process chosen for the manufacturing of lithium/polymer batteries does not generate any particular risk of personnel or environmental contamination. Security tests have permitted to observe and analyze the behaviour of 4 Ah elements during thermal shocks, perforation and crushing, and during external short-circuit on 20 Ah elements. These tests demonstrate the great thermal stability and the excellent behaviour of batteries in the case of partial destruction. (J.S.) 2 refs.

  10. AIRIX: an induction accelerator facility developed at CEA for flash radiography in detonics

    Science.gov (United States)

    Cavailler, Claude

    1999-06-01

    AIRIX is an induction linear accelerator which will be used for flash radiography in CEA/DAM. Designed to produce an X-ray dose of more than 500 Rads at 1 meter with an X-ray focal spot size diameter of less than 2 mm (LANL-CEA DAM definition), this facility consists in a 4 MeV/3.5 kA pulsed electron injector and 16 MeV induction accelerator powered by 32 high voltage generators. A prototype of this accelerator, called PIVAIR, has been studied and realized in CEA CESTA near Bordeaux. PIVAIR is a validation step for AIRIX at 8 MeV. It includes an injector (4 MeV, 3.5 kA, 60 ns) and 16 inductor cells supplied by 8 high voltage generators (250 kV, 70 ns). Two different technologies of induction cells have been tested (rexolite insulator or ferrite under vacuum). We have chosen ferrite under vacuum cells technology after comparison of results on beam transport and reliability tests. A focusing experiment at 7.2 MeV of the electron beam as been achieved during summer 1997. We have begun to produce X-rays in October 1997. A dose level of 50 Rad at 1 meter has been achieved with an X-ray spot size diameter of 3.5 to 4 mm (LANL-CEA DAM definition). Static flash radiography of very dense object have been achieved from November 97 until February 98. We have been able to test in situ new kinds of very high sensitive X- ray detectors and to check they had reached our very ambitious goals: (1) quantum efficiency at 5 MeV greater than 50% instead of 1% for luminous screens and film; (2) sensitivity less than 10 (mu) Rad (100 time more sensitive than radiographic luminous screens and films); (3) dynamic range greater than 100; (4) resolution less than 2 mm. We will present in this communication brand new kinds of detection systems, called high stopping power detectors, such as: (1) (gamma) camera with segmented thick crystal of BGO and MCP image intensifier; (2) multistep parallel plate avalanche chamber; (3) pixellized CdTe MeV photoconductor matrix. AIRIX accelerator is being

  11. Actinides exposure: review of Ca-DTPA injections inside Cea-Cogema plants

    International Nuclear Information System (INIS)

    Ca-DTPA has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This report is a survey of the injections administered of Ca-DTPA as a chelating molecule. This report will be a part of the AMM process for Ca-DTPA by intravenous administration submitted by the Central Pharmacy of the french Army. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contaminations were reported. These employees were followed by occupational physicians according to the current regulations. The first part of the report is a synthesis of the most recent findings. Due to its short biological period and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary. The second part presents data concerning these 1158 injections (way of contamination, posology, adverse effects...). These incidents took place at work, were most often minor, not requiring follow-up treatment. A study concerning the effectiveness of the product was done on a group of people having received 5 or more injections. These results were compared with effectiveness estimated from theoretical basis. Posologies and therapeutic schemes were proposed based on these observations. Additional studies are needed to confirm these findings. This document is the first synthesis in this field. It is the result of a collective work having mobilized the occupational medicine departments, the laboratories of CEA and COGEMA and a working group CEA-COGEMA-SPRA. (authors)

  12. CEA studies and qualifications prior to the JT-60SA TF coils manufacture

    International Nuclear Information System (INIS)

    Following the first conceptual design activity in which the general design of the JT-60SA TF system was defined in agreement with all the participants in the project (CEA, ENEA, F4E), a second phase dealing with the detailed design was engaged by each of the voluntary contributors. For the French part which includes the procurement of 9 of the TF winding packs and their integration in the casing, an industrial contract was signed mid 2011 with Alstom (France). Several actions have been carried out to prepare the manufacturing phase. To precisely define one of the main interfaces which is the temporary electrical connection of the coils to the current leads during cold test in the CEA facility as well as their final connection to the feeders at the Naka site, a design compatible with both requirements was developed by CEA, supported by the previous developments led on the joints and assembly techniques. In addition to prepare the coils manufacture, hydraulic qualification was led on the first conductor qualification length to set the parameters which will be used by the coils manufacturer for conductor acceptance. At last, mechanical characterizations of both the conductor and of the empty compacted jacket were performed in order to define as precisely as possible the elastic and plastic properties of these components. These are crucial properties used during the bending process which is one of the most important operations during the winding pack manufacture. These data will be very helpful for the winding machine parameters settings as well as for designing the local bending tooling needed to shape the conductors extremities at the connection area and at the double pancakes joggles

  13. Annual report of the Association EURATOM-Cea 2004 (full report)

    International Nuclear Information System (INIS)

    This annual report summarizes activities performed by the EURATOM-Cea association in 2004. The activities carried out in the field 'physics integration' are mainly linked to neutral beam developments and to the development of diagnostic components. In particular, in-situ diagnostics of the plasma facing surface have been studied. Concerning 'vessel activities', the manufacturing of the ITER primary first wall panel by HIP forming has been investigated. A dummy mock-up was produced to validate the manufacturing feasibility. A new welding process able to improve welding productivity has been investigated, it is based on a hybrid laser/TIG process called Hybrid Laser Conduction Welding. A ITER first wall mock-up has been successfully manufactured using induction brazing. In the field 'magnets', EURATOM-Cea association was involved to provide input information for establishing the final dimension details of the ITER cryo-plant. EURATOM-Cea is also involved with the design of different parts of the ITER magnet system and the fabrication of mock-ups for some critical parts of the coils. In the field 'tritium breeding and materials', activities have mainly concerned the improvement and completion of the TBM (tritium breeding module) engineering design. A new batch of 1 kilogram of Li2TiO3 pebbles with a size distribution in the range 0.6 to 0.8 mm was produced in 2004. Concerning materials, activities were focused on the EUROFER, a reduced activation martensitic steel. Activities performed in the field 'system studies' are dedicated to the power plant conceptual studies. In 2004, activities were focused on the reactor model AB, based on a helium-cooled lithium-lead blanket. (A.C.)

  14. Prognostic value of monitoring tumour markers CA 15-3 and CEA during fulvestrant treatment

    Directory of Open Access Journals (Sweden)

    Locker Gottfried J

    2006-03-01

    Full Text Available Abstract Background At many centres tumour markers are used to detect disease recurrence and to monitor response to therapy in patients with advanced disease, although the real value of serial observation of marker levels remains disputed. In this study, we evaluated the prognostic value of tumour markers for predicting response (partial response [PR], stable disease [SD] ≥ 6 months, de novo disease progression (PD and secondary PD in patients receiving fulvestrant ('Faslodex' 250 mg/month for the treatment of metastatic breast cancer (MBC. Methods Changes in cancer antigen 15–3 (CA 15-3 and carcinoembryonic antigen (CEA were prospectively monitored (monthly and were also evaluated for the 3 months preceding secondary PD. Data from 67 patients with previously treated MBC participating in a Compassionate Use Programme were analysed. Results In patients with a PR (n = 7 [10.4%], a non-significant increase in CA 15-3 occurred during the first 6 months of treatment; CEA was significantly reduced (P = 0.0165. In patients with SD ≥ 6 months (n = 28 [41.8%], both CA 15-3 (P P = 0.0399 levels increased significantly after 6 months treatment. In those experiencing de novo PD (n = 32 [47.8%], CA 15-3 increased significantly (P P = 0.0002 during the same time period. Both CA 15-3 (P P Conclusion CA 15-3 increases in patients progressing on fulvestrant but may also increase in those experiencing clinical benefit; this should not be taken as a sign of PD without verification. Overall, both CA 15-3 and CEA appear to be poor prognostic markers for determining progression in patients receiving fulvestrant.

  15. Report on nuclear safety and transparency 2011 - NBI operated by the CEA in Marcoule

    International Nuclear Information System (INIS)

    After a brief presentation of the Marcoule CEA centre, this report indicates the different safety measures related to different risks, to emergency situations, to inspections and audits, and to nuclear base installations (INB). It describes measures related to radiation protection and some remarkable facts which occurred in 2010. It presents the different significant events which occurred in 2011 and were declared to the ASN. It discusses the results of measurements of releases from the installations and their impact on the environment. It addresses the radioactive wastes which are warehoused on the site (measures to limit their volume and to limit their impact on health and on the environment, notably on water and soils)

  16. Decay heat calculations with the CEA radioactivity data bauk and the code PEPIN

    International Nuclear Information System (INIS)

    The CEA radioactivity data bank, has been updated mainly from ENSDF and from some recent experimental results. This library contains the decay data for about 700 fission products (F.P.), 220 actinides and more than 1400 other nuclides. A comparison between our data and ENDF/B5 is shown for the fission products. The fission products part of this library is currently used for shielding and decay heat calculations with the PEPIN code. Calculations and spectral comparisons of the available experiments (Dickens, Lott, Yarmell ...) and other recent calculations is made for thermal fission of 235U and 239Pu using our data bank as input

  17. Ocular rosacea: a review Rosácea ocular: revisão

    Directory of Open Access Journals (Sweden)

    Ana Carolina Cabreira Vieira

    2012-10-01

    Full Text Available Rosacea is a prevalent chronic cutaneous disorder with variable presentation and severity. Although considered a skin disease, rosacea may evolve the eyes in 58-72% of the patients, causing eyelid and ocular surface inflammation. About one third of the patients develop potentially sight-threatening corneal involvement. Untreated rosacea may cause varying degrees of ocular morbidity. The importance of early diagnosis and adequate treatment cannot be overemphasized. There is not yet a diagnostic test for rosacea. The diagnosis of ocular rosacea relies on observation of clinical features, which can be challenging in up to 90% of patients in whom accompanying roseatic skin changes may be subtle or inexistent. In this review, we describe the pathophysiologic mechanisms proposed in the literature, clinical features, diagnosis and management of ocular rosacea, as well as discuss the need for a diagnostic test for the disease.A rosácea é uma condição cutânea crônica, que possui apresentações clínicas variáveis. Apesar de considerada uma doença dermatológica, os olhos podem ser acometidos em 58-72% dos casos, causando inflamação palpebral e da superfície ocular. Aproximadamente um terço dos pacientes desenvolve acometimento corneano, podendo causar baixa visual significativa. Diagnóstico precoce e tratamento adequado são de extrema importância, devido à significativa morbidade ocular que a doença pode causar. Não há, até o momento, um teste diagnóstico para rosácea. O diagnóstico da rosácea ocular depende da observação das manifestações clínicas, o que pode ser bastante desafiador em até 90% dos pacientes, em que os achados cutâneos são discretos ou inexistentes. Nesta revisão, descrevemos os mecanismos fisiopatológicos propostos na literatura, manifestações clínicas, diagnóstico e tratamento da rosácea ocular, assim como abordamos a necessidade de um teste diagnóstico.

  18. Introduction to CEA studies on future nuclear energy systems and nuclear desalination

    International Nuclear Information System (INIS)

    Nuclear energy has unique assets to meet the requirements for sustainable development in terms of economic competitiveness, safety, environmental friendliness and natural resources saving. The growth in world energy demand and future prospects of the decommissioning of existing power plants has stimulated the development of a new generation of nuclear energy systems intended to be more economically competitive, safer and more sustainable. The French Atomic Energy Commission (CEA) is strongly involved in advancing nuclear energy technology to meet future energy needs. The Generation IV Initiative provides an adequate framework to organise future R and D efforts for the development of innovative nuclear systems able to meet the requirements of a sustainable energy policy in terms of economic competitiveness, safety, environmental friendliness and natural resources saving. While covering most reactor technologies, the effort of the CEA is essentially focused on the development of a three-step set of gas-cooled systems. Besides the development of new concepts, the need to provide potable water to the expanding population in arid regions is potentially an emerging application for nuclear power. Its practical implementation requires parallel efforts to develop the needed technologies and to address specific aspects of their coupling with nuclear power plants. After a short recall on the Gen IV goals for future nuclear energy systems, the paper motivates the selection of a consistent range of high temperature gas cooled modular systems as a major focus for future studies. A preliminary overview of the reference concepts for the innovative set of gas cooled nuclear systems - namely the Very-High-Temperature Reactor (VHTR) and the Gas-Cooled Fast Reactor System (GFR) is given. Finally, the CEA's activities on nuclear desalination are quickly discussed: the EURODESAL project within the 5th R and D Framework Programme of the European Union; the TUNDESAL project, which is a

  19. Charting a course through the CEAs: diagnosis and management of medullary thyroid cancer.

    Science.gov (United States)

    Rowe, Christopher W; Bendinelli, Cino; McGrath, Shaun

    2016-09-01

    Medullary thyroid cancer (MTC) is an uncommon thyroid cancer that requires a high index of suspicion to facilitate diagnosis of early-stage disease amenable to surgical cure. The challenges of diagnosis, as well as management in the setting of persistent disease, are explored in the context of a case presenting with the incidental finding of elevated carcinoembryonic antigen (CEA) and an (18) F-fluorodeoxyglucose positron emission tomography ((18) F-FDG-PET)-positive thyroid incidentaloma detected following treatment of colorectal cancer. Strategies to individualize prognosis, and emerging PET-based imaging modalities, particularly the potential role of (18) F-DOPA-PET in staging, are reviewed. PMID:27230389

  20. The evaluation of the nuclear facilities safety at the CEA from 1999 to 2001

    International Nuclear Information System (INIS)

    The aim of this document is the presentation of an evaluation of the problems and the safety methods in the concerned period. The first chapter presents the nuclear safety in the CEA. The second chapter is devoted to the organization and the quality for the safety: liabilities, audits, relations with the safety authorities and with the public. The chapters three and four deal respectively with the methodological and technical abilities supporting the exploitation teams and with the nuclear safety projects. The last chapter presents the experiments and events from 1999 to 2001. (A.L.B.)

  1. Evaluation of the radiology state at the CEA/Fontenay-aux-Roses and its environment

    International Nuclear Information System (INIS)

    Since 1946 the nuclear installations followed one other at the CEA of Fontenay-aux-Roses still their gradual stop the last ten years, except two installations INB34 and INB73, necessary for the wastes management. Today these installations form the subject of a drainage program. The public opinion is regularly informed on this program since 1999. This document presents the stock of the actions realized since this date: the track keeping of the sites activities impacts on the environment and the actions realized since 1999. (A.L.B.)

  2. Changes in soluble CEA and TIMP-1 levels during adjuvant chemotherapy for stage III colon cancer

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Christensen, Ib Jarle; Sölétormos, György; Jess, Per; Nielsen, Svend Erik; Brünner, Nils; Nielsen, Hans J.

    2010-01-01

    Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antige...... (CEA) levels in patients with stage III colon cancer.......Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antigen...

  3. List of reports from reactor safety research of BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning special Problems in the field of Reactor Safety Research. According to the cooperation of the Bundesminister fuer Forschung und Technologie (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technologie Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these Reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programm of the BMFT, reporting organization. The list of reports appears quarterly. (orig.)

  4. Annual report of the Association EURATOM-Cea 2004 (executive summary)

    International Nuclear Information System (INIS)

    Progress in fusion technology is constant over the years and this report once again highlights a number of important steps that have been accomplished in this domain. This document is the executive summary of the full annual report, summarizing activities performed by the EURATOM-Cea association. This report has been organized into 10 issues: 1) physics integration, 2) reactor vessel, 3) plasma facing components, 4) remote handling, 5) magnets structures, 6) tritium breeding blankets, 7) structural material, 8) safety and environment, 9) system study, and 10) ITER site preparation

  5. Annual report of the Association EURATOM-Cea 2005 (executive summary)

    International Nuclear Information System (INIS)

    Progress in fusion technology is constant over the years and this report once again highlights a number of important steps that have been accomplished in this domain. This document is the executive summary of the full annual report, summarizing activities performed by the EURATOM-Cea association. This report has been organized into 10 issues: 1) physics integration, 2) reactor vessel, 3) plasma facing components, 4) remote handling, 5) magnets structures, 6) tritium breeding blankets, 7) structural material, 8) safety and environment, 9) system study, and 10) ITER site preparation

  6. CEA program on future generation light water modular reactors and gas cooled reactors

    International Nuclear Information System (INIS)

    The CEA programme on 'Future Generation Reactors and Fuel Cycles' aims at studying and developing the mean and long term most promising options for nuclear reactors, fuels and reprocessing. These options should contribute to make the nuclear energy a major source of the sustainable development. The program also aims at maintaining at the highest level of competency the technologies with which the CEA will be able to bring to national achievements or international projects in the next decades, projects whose specifications and calendar are today unknown. These studies on the 'Future Generation Reactors and Fuel Cycles' constitute a field privileged for international collaboration. The corresponding researches are structured in four main axes: Innovations for LWR; Systems of 4th generation; Sodium-cooled reactors; Systems which are the object for survey or exploratory studies. Studies on future nuclear gas technologies are mainly covered by the 4th generation programme (Gen IV). Within this context, the goals pursued, in particular the minimization of the production of long lived waste and the saving of resources (i.e.: the optimised utilisation of fissile and fertile nuclear fuels), could justify an evolution towards hard neutron spectra and high temperatures, to cover applications other than the electricity production, e.g.: hydrogen production, desalination, cogeneration. The main R and D axis for these long-term objectives currently the area of Gas Cooled Reactors (GCR). The corresponding program is structured through eight R and D projects details of which are presented within the paper. (author)

  7. Overview of the CEA R and D support to generation IV nuclear energy systems

    International Nuclear Information System (INIS)

    As a result of an early technology road-map performed at the end of 2000, the CEA selected a sequenced development of advanced gas cooled high temperature nuclear systems as main focus for its R and D programme on future nuclear energy systems. The selection of this research objectives originates both from the significance of fast neutrons and high temperature for nuclear energy to meet the needs anticipated beyond 2020/2030, and from the significant common R and D pathway that supports both medium term industrial projects and more advanced versions of gas cooled reactors. The first step of the 'Gas Technology Path' aims to support the development of a modular HTR likely to meet international market needs around 2020. The second step is a Very High Temperature Reactor (> 950 deg. C) to efficiently produce, among others, hydrogen though thermo-chemical water splitting or to generate electricity with an efficiency above 50%. The third step of the Path is a Gas Fast Reactor that features a fast-spectrum helium-cooled reactor and closed fuel cycle, with a direct-cycle helium turbine for electricity production and full recycle of actinides. The paper succinctly presents the R and D program launched in 2001 by the CEA with industrial partners on the 'Gas Technology Path', which is destined to become the contribution of France to the development of the VHTR and the GFR within the next phase of the Generation IV Forum

  8. 2007-2008 activity report of the Association EURATOM-CEA (Full Report)

    International Nuclear Information System (INIS)

    This document summarizes the activities performed by EURATOM-CEA association in 2007-2008. The activities are various and have involved different issues like the study of dust generation processes and measurement techniques, ICRH antenna design for heating, integration studies inside the port-plug for diagnostics and in-situ divertor thermography, or the helium cooled lithium lead (HCLL) breeding blanket concept. Activities have been made to study the properties of the line defects governing the plastic behavior of iron base materials. Different options have been investigated for the superconducting magnet system. The measurement of in-vessel tritium inventory by laser induced breakdown spectroscopy (LIBS) technique has been investigated. 2007-2008 were also dedicated to the manufacture and complete tests of the AIA (Articulated Inspection Arm). AIA is designed to inspect divertor cassettes and the vacuum vessel first wall. Activities based on safety analysis or tests of ITER safety open issues have been carried out using several CEA facilities and expertise. This document is divided into 5 sections: 1) physics integration, 2) in-vessel, 3) magnet system and cryogenics, 4) tritium breeding and materials, 5) safety and environment, 6) system studies, 7) design support and procurement, 8) JET technology

  9. Significance of the fuel cycle aspects in CEA studies on future nuclear systems

    International Nuclear Information System (INIS)

    Nuclear energy has unique assets to meet the requirements for a sustainable development in terms of economic competitiveness, environmental friendliness and natural resources saving. Future nuclear system studies conducted by the CEA aim at investigating and developing promising technologies for the medium and the long term for reactors, fuels and the fuel cycle to make nuclear power eligible as one of the major energy sources of the sustainable development. It also aims at maintaining at the best possible level the expertise and the technologies that the CEA will be able to bring to future national and international projects likely to meet market needs in the next decades, which are still uncertain both in terms of performances and time scale. Progress for future nuclear systems is principally sought in the following areas: reinforced economic competitiveness against other available electricity generation means, with a special emphasis put on reducing the investment cost; enhanced safety, especially through an increased resistance to core damages in case of severe accident, and whenever possible by dedicated strategies to exclude core melting; cleanliness through minimising the production of long lived radioactive waste; resource saving through an optimum utilisation of the available resources of fissile and fertile materials; enhanced resistance to proliferation risks; potentialities for other applications than electricity production. (author)

  10. Research and development performed at CEA/DMT in the field of nuclear reactors containments

    International Nuclear Information System (INIS)

    The behavior of containment is a key issue with respect to the safety of nuclear power plants. Extensive work has been performed for many years at CEA/DMT (Department of Mechanics and Technology) on this subject particularly on the behavior of containment under severe accidents. Large research and development programs have been carried out and are still under progress to handle the following problems: thermo-mechanical response on the containment under increasing pressure and temperature up to the ultimate behavior of the structure; behavior of the containment in case of hydrogen detonation or steam explosion; modelization and evaluation of containment leaking after a severe accident inducing cracks in the structure; and response of the containment to seismic loads. These studies have been carried out by means of finite element computations. The computer codes have been developed and validated using either analytical solutions or experimental results. Specific developments have been made in order to be able to solve the above mentioned problems: material models for reinforced concrete; fast dynamic algorithms for impacts; seismic analysis techniques and soil-structure interactions; and gas dynamics, shock waves and fluid-structure interaction. More recently, new programs have also been undertaken, concerning the behavior of containment after core melt and vessel break through. Work is in progress at CEA/DMT in the two following areas: conceptual studies concerning core catcher and residual power evacuation and design method development of core catcher, including numerical code development

  11. Development of a DNBR evaluation method for the CEA ejection accident in SMART core

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Dae Hyun; Yoo, Y. J.; In, W. K.; Chang, M. H. [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-12-01

    A methodology applicable to the analysis of the CEA ejection accident in SMART is developed for the evaluation of the fraction of fuel failure caused by DNB. The transient behavior of the core thermal-hydraulic conditions is calculated by the subchannel analysis code MATRA. The minimum DNBR during the accident is calculated by KRB-1 CHF correlation considering the 1/8 symmetry of hot assembly. The variation of hot assembly power during the accident is simulated by the LTC(Limiting transient Curve) which is determined from the analysis of power distribution data resulting from the three-dimensional core dynamics calculations. The initial condition of the accident is determined by considering LOC(Limiting Conditions for Operation) of SMART core. Two different methodologies for the evaluation of DNB failure rate are established; a deterministic method based on the DNB envelope, and a probabilistic method based on the DNB probability of each fuel rod. The methodology developed in this study is applied to the analysis of CEA ejection accident in the preliminary design core of SMART. As the result, the fractions of DNB fuel failure by the deterministic method and the probabilistic method are calculated as 38.7% and 7.8%, respectively. 16 refs., 16 figs., 5 tabs. (Author)

  12. Activities on the physics of accelerator-based systems at CEA

    International Nuclear Information System (INIS)

    Nowadays, the interest for accelerator-based systems (ABS) in France is strongly related to the studies on long-lived radioactive waste management. Investigations aim to indicate whether ABS can play a role beside critical reactors in the process proposed to reduce the long term radiotoxicity of nuclear wastes. ABS is not envisaged to replace reactors for energy production even if the energy production is a mean to reduce the transmutation cost. Several French organisms (CEA, EDF, CNRS) are interested by ABS studies. Activities are shared out amongst different laboratories and involve international cooperation. The program aims at evaluating ABS performances for the report on waste management foreseen in 2006 and not at developing a project. This ABS evaluation concerns the following items: potential of radiotoxicity reduction, safety, economy, feasibility which must be compared with those of critical reactors. To achieve this end, activities at CEA are in progress on: - code development and validation, - nuclear data evaluation, -theoretical investigations on ABS characteristics, - study of existing projects. (author) 2 figs., 2 tabs., 8 refs

  13. Treatment of actinide exposures: a review of Ca-DTPA injections inside CEA-COGEMA plants

    International Nuclear Information System (INIS)

    Calcium diethylenetriamine pent-acetate (Ca-DTPA) has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This paper is a survey of the injections Ca-DTPA administered as a chelating molecule and it will be a part of the authorization process for Ca-DTPA by intravenous administration. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contamination were reported. These employees were followed by occupational physicians according to the current French regulations. These incidents took place at work, were most often minor, not requiring follow-up treatment. The authors present (1) a synthesis of the most recent findings. Due to its short biological half-time and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary (2) data concerning these 1158 injections (route of contamination, dosage, adverse effects, etc.) The authors also investigated a study on the efficacy of the product on a group of persons having received five or more injections. These results were compared with the efficacy estimated theoretically. Dosages and therapeutic schemes were proposed based on these observations. This synthesis is the result of a collective work having mobilized the occupational medicine departments, the medical laboratories inside a working group CEA-COGEMA-SPRA. (authors)

  14. 2007-2008 activity report of the Association EURATOM-CEA (Executive summary)

    International Nuclear Information System (INIS)

    This document is the executive summary of the full report, summarizing activities performed by EURATOM-CEA association in 2007-2008. The activities are various and have involved different issues like the study of dust generation processes and measurement techniques, ICRH antenna design for heating, integration studies inside the port-plug for diagnostics and in-situ divertor thermography, or the helium cooled lithium lead (HCLL) breeding blanket concept. Activities have been made to study the properties of the line defects governing the plastic behavior of iron base materials. Different options have been investigated for the superconducting magnet system. The measurement of in-vessel tritium inventory by laser induced breakdown spectroscopy (LIBS) technique has been investigated. 2007-2008 were also dedicated to the manufacture and complete tests of the AIA (Articulated Inspection Arm). AIA is designed to inspect divertor cassettes and the vacuum vessel first wall. Activities based on safety analysis or tests of ITER safety open issues have been carried out using several CEA facilities and expertise

  15. Aportación al conocimiento de las algas epicontinentales del S.E. de España. VI. Dinofíceas (Dinophyceae Fritsch. 1927) y Euglenofíceas (Euglenophyceae Schoenichem, 1925).

    OpenAIRE

    Aboal Sanjurjo, Marina

    1990-01-01

    En prospecciones algológicas realizadas durante los años 1982-85 por todo el sudeste español y en especial en la cuenca del Segura se han identificado 7 táxones de Dinofíceas y 15 de Euglenofíceas. 18 de ellas son novedad para la flora algológica del sudeste español y 3 para la flora española. Se reúnen en tablas los valores de los principales factores físicoquímicos del agua para cada especie

  16. Report of the CEA visiting committee on R and D for future nuclear energy systems, May 11-13, 2005

    International Nuclear Information System (INIS)

    This was the fifth meeting of the Visiting Committee of the CEA since its creation in year 2000. The first meeting gave members of the committee a broad overview of the entire spectrum of CEA research and subsequent meetings have focused on specific topics. These included the nuclear fuel cycle, biology, and micro and nano technologies. This meeting focused on research and development for future nuclear energy systems. The main division of CEA concerned with this topic is the Nuclear Energy Division. Some of the laboratories of the Technological Research and Matter Science Divisions are also involved in areas such as materials and basic nuclear data. The report deals with the fuels and waste, the SFR (Sodium Fast Reactor) and GFR (Gas Fast Reactor) programs, the Very High temperature reactor (VHTR), the actinide separation, the materials, the irradiation tests facilities and the personnel for the future. (A.L.B.)

  17. Uptake of radiolabeled anti-CEA antibodies in human colorectal primary tumors as a function of tumor mass

    International Nuclear Information System (INIS)

    An inverse correlation has been demonstrated between tumor uptake (u, in units of % injected dose/kg) of monoclonal antibody (Mab) and tumor mass (m, in units of g) for colorectal carcinoma in a series of 19 consecutive patients. The correlation (ρ=-0.510), developed using surgical samples was of the form u=abb and was significant at the 2% level of confidence. All tumors were positive for carcinoembryonic antigen (CEA) and the radiopharmaceutical was in iodine-131 labeled anti-CEA Mab. Such correlations have been predicted earlier from murine and rat tumor uptake data. The slope parameter (b) was -0.362, a number consistent with the previous value (-0.382) found in anti-CEA experiments in mice bearing human xenograft LS174T tumors. (orig.)

  18. The new technology in high temperature gas-cooled reactor. The fifth anniversary of CEA/INET cooperation

    International Nuclear Information System (INIS)

    In 2001, CEA and INET signed the first agreement and a series of specific topics of cooperation (STC), which officially launched the cooperated program on HTGR technology between the two sides, Since 2002, INET has sent dozens of researchers to CEA on both short and long term basis to work with their French counterparts. Over the past five years, they have worked together in a variety of fields, such as materials, fuel, components and reactor physics. Besides, both sides sponsored workshops and technical visits to tackle the major problems. This volume with a collection of papers not only keeps a record of technical progress contributed by both sides, but also marks the fifth anniversary cooperation between CEA and INET. (authors)

  19. An illustration of how sciences may be combined at Cea: parallel progress in superconductivity, particle physics, medical imaging and fusion

    International Nuclear Information System (INIS)

    Superconductivity was hailed as the most important achievement of modern physics when it was discovered in 1911. Since then the enthusiasm has damped a bit because superconductivity still requires very low temperatures. This article gives an historical account of the application of superconductivity to the research programs and achievement of Cea (French atomic energy board). The first uses were dedicated to the design of superconducting magnets. We can note the delivery in 1989 of 246 quadrupolar magnets for bending particle beams for the HERA accelerator. As for the LHC (large hadron collider) project, Cea-Grenoble has a key role in the development of the cryogenic system and Cea-Saclay is responsible of the design of 400 quadrupolar magnets, it will have to fabricate 3 prototypes and the mass production will be made in Germany. A second sector involving superconductivity is thermonuclear devices through magnetic confinement. Tore-Supra has been for 10 years the only big fusion machine involving a superconducting system. In ITER all the coils necessary to the plasma confinement will be superconducting, it will represent 700 tons of superconducting wires. The research programs linked to the ITER project have led to the design of a new superconducting material: the niobium-tin (Nb3Sn). A third sector is medical imaging in which Cea is involved since the eighties. Cea-Saclay will home the Neurospin center whose purpose is to assess the limit of brain imaging from mice to man. Cea has to design magnets in the range of 11 tesla with a one meter broad clearance, the selected technology is that of superconducting magnets cooled by pressurized superfluid helium. (A.C.)

  20. CEA, CYFRA 21-1, NSE, and ProGRP in the diagnosis of lung cancer: a multivariate approach

    OpenAIRE

    Gruber, Christine; Hatz, Rudolf; Reinmiedl, Judith; Nagel, Dorothea; Stieber, Petra

    2008-01-01

    We retrospectively studied the single and combined diagnostic value of carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), neuron specific enolase (NSE) and pro-gastrin-releasing peptide (ProGRP), which were routinely analysed in patients with lung tumours of unknown origin at the time of admission to hospital. Inclusion criteria were the determination of CEA (AxSYM/Abbott), CYFRA 21-1 (ElecSys/Roche) and NSE (Kryptor/Brahms). We examined 1747 patients, where 1325 suffered f...

  1. Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis

    OpenAIRE

    Zhang, Yimin; Yang, Jun; Li, Hongjuan; WU, YIHUA; Zhang, Honghe; Chen, Wenhu

    2015-01-01

    Background: Pancreatic cancer has the worst prognosis and early detection is crucial for improving patient prognosis. Therefore, we performed a meta-analysis to evaluate and compare the sensitivity and specificity of single test of CA19-9, CA242, and CEA, as well as combination test in pancreatic cancer detection. Methods: We searched PubMed, Embase, Medline, and Wanfang databases for studies that evaluated the diagnostic validity of CA19-9, CA242, and CEA between January 1990 and September 2...

  2. The possible role of tumor antigen CA 15-3, CEA and ferritin in malignant and benign disease

    Directory of Open Access Journals (Sweden)

    Nafija Serdarević

    2012-09-01

    Full Text Available Introduction: Serum CA15-3 has been one of the most reliable tumor markers used in monitoring of breast cancer patients. To increase its sensitivity, the combined measurement of other tumor markers (CEA and ferritin with CA15-3 was investigated. The aim of this study was determination of CA 15-3, CEA and ferritin in female patients with breast cancer, lung cancer and mastitisMethods: 300 patients with carcinoma, hospitalized at Department of Gynecologic Oncology and Department for Oncology at the University Clinics Center of Sarajevo and 200 healthy subjects were compared.Results: In patients with breast cancer the mean value of tumor markers were CEA 155.61 ng/mL, CA 15-3 106.38 U/mL and ferritin 197.03 ng/mL. In patients with lung cancer CEA was 58.97 ng/ml, CA 15-3 40.62 U/mL and ferritin 544.16 ng/mL. Patients with mastitis had CEA 5.17 ng/mL, CA 15-3 112.67 U/mL and ferritin 174.92 ng/mL. The control group had values of tumor markers CEA 1.62 ng/mL, CA 15-3 11.72 U/mL and ferritin 85.35 ng/mL. We found good correlation between CA 15-3 and CEA correlation coeffi cient was r = 0.750. There was a low correlation between CA 15-3 and ferritin with correlation coeffi cient r = 0.274.Conclusions: The CA 15-3 and CEA are useful markers in patients with confi rmed diagnosis of breast and lung cancers. The ferritin concentration has not increased in patients with breast cancer but it increased inlung patients. The future study has to make investigations of tumor markers and ferritin in different stage of breast cancer.

  3. A produção de anonáceas no Brasil

    Directory of Open Access Journals (Sweden)

    Eurico Eduardo Pinto de Lemos

    2014-01-01

    Full Text Available As anonáceas compõem um grupo de plantas que se têm destacado em várias partes do mundo, principalmente por produzirem frutos de grande interesse comercial. Entre os mais destacados membros desta família, estão a cherimólia (Annona cherimola, a pinha (A. squamosa, a atemoia (híbrido A. squamosa x A. cherimola, e a graviola (A. muricata. No Brasil, pelas suas características de clima tropical e com baixas altitudes na maior parte de seu território, a cherimólia tem sido pouco cultivada devido a sua exigência em temperaturas baixas. As demais apresentam áreas cultivadas em diversas regiões do País para fazer frente à demanda dos mercados de frutas frescas (pinha e atemoia e processadas (graviola. Todavia, o interesse neste grupo de plantas é mais abrangente, tendo em vista que inúmeras pesquisas comprovam que compostos secundários obtidos de várias anonáceas possuem atividade pesticida e antitumoral. Este trabalho objetiva apresentar um quadro atual da produção de anonáceas no Brasil, focando nas principais anonas cultivadas nas diferentes regiões do País. Para tanto, foram levantados dados de produção e principais tecnologias utilizadas nestas culturas. Os dados de produção obtidos serviram para estabelecer uma estimativa aproximada da realidade da produção de atemoia, pinha e graviola no Brasil. Os resultados demonstram um vigoroso crescimento na área total de cultivo, na produção e no uso de tecnologias modernas para as três espécies consideradas neste estudo. Apontam também para uma expansão dos cultivos em todas as regiões do Brasil, principalmente no Nordeste.

  4. KROTOS FCI experimental programme at CEA Cadarache: new features and status

    Energy Technology Data Exchange (ETDEWEB)

    Bonnet, J.M.; Bullado, Y.; Journeau, C.; Fouquart, P.; Piluso, P.; Sergeant, C.; Magallon, D. [CEA-Cadarache, DTN/STRI/LMA, Bat 708, BP1, 13108 Saint Paul lez Durance cedex (France)

    2005-07-01

    Full text of publication follows: KROTOS facility has been operated by the European Commission at JRC-Ispra for many years until 1999 as part of the FARO/KROTOS programme. The programme had to be stopped at JRC due to new EC priorities, and an agreement was concluded with CEA to transfer the KROTOS facility and know-how to Cadarache to continue investigating the pending FCI issues. By this agreement, CEA became owner of the facility. The main objective of the KROTOS programme at CEA Cadarache is understanding the role of melt properties in steam explosion propagation and energetics and, in particular, steam explosion behaviour of prototypical corium melts. Possible influence of physicochemical processes on explosiveness will also be explored. Actually, analysis of alumina debris produced at Ispra have shown that formation of metastable phases and chemical reaction with water at high temperature may play a significant role in enhancing heat transfer to water in the explosion phase. In order to reach the objective, steam explosion experiments are performed in well characterised conditions for a large spectrum of conditions and melt compositions of interest for both in- and ex-vessel situations. A trigger is applied as a rule. Advanced technology and instrumentation is used to reduce uncertainties on initial conditions and characterise the various phases of an explosion, with emphasis on high energy X-ray cinematography to qualify pre-mixing. This advanced instrumentation will enable the measurement of detailed variables to consolidate the qualification of the FCI codes. The use of high energy X-rays made it necessary to construct a new building to house the facility and its components. The facility should newly become operative early 2005. Main improvements with respect to Ispra concern melt delivery, hydrogen measurement and X-ray imaging. Preliminary studies have demonstrated that identification of the pre-mixture-water interface and coherent melt jet core, and

  5. Establishment of 131I, 99mTc Labeling Methods to In-house Anti-CEA Antibodies and Evaluation of the Immunological Characteristics

    International Nuclear Information System (INIS)

    Cancer cells have several tumor-associated antigens on the cell surfaces, and antibodies against these antigens have been developed by many investigators. Radiolabeled antibodies have been used as new methods to diagnose and treat malignant tumors. Especially anti-carcinoembryonic antigen (CEA) is the most popular antibody for these purposes. In this investigation, we tried to label 131I and 99mTc to anti-CEA monoclonal antibodies which were developed in the Seoul National University College of Medicine. We found CEA-79 and CEA-92 antibodies had the better immunological characteristics among 8 anti-CEA monoclonal antibodies. And radioiodination of CEA-79 could be performed by chloramine-T method, while radioiodination of CEA-92 by iodogen method. To label these antibodies with 99mTc, we used pretargeting transchelation as direct labeling method. At first, 99mTc was bound to glucaric acid, and monoclonal antibody was reduced by β-mercaptoethanol. When these were incubated together, 99mTc bound to glucarate was switched to monoclonal antibody because of higher affinity. We established conditions of several steps in this method. Anti-CEA monoclonal antibodies labeled with 131I and 99mTc are expected to be used valuably in the detection and treatment of malignant tumors.

  6. Serum tetranectin is an independent prognostic marker in colorectal cancer and weakly correlated with plasma suPAR, plasma PAI-1 and serum CEA

    DEFF Research Database (Denmark)

    Høgdall, Claus K; Christensen, Ib J; Stephens, Ross W;

    2002-01-01

    activator (uPAR) and carcinoembryonic antigen (CEA). Significantly shorter survival was found for patients with TN levels below a cut-off point of 7.5 mg/l compared to patients with levels above, as illustrated by Kaplan-Meier curves. By Cox analyses, log TN, log soluble uPAR as well as log CEA were found...

  7. Report on nuclear safety and transparency 2011 - Fontenay-aux-Roses CEA centre

    International Nuclear Information System (INIS)

    After a brief presentation of the Fontenay-aux-Roses CEA centre, this report indicates the different safety measures in the different nuclear base installations (INB) of this site (measures related to different risks, to emergency situations, to inspections and audits). It describes measures related to radiation protection: organisation, dosimetry results. It presents the different significant events which occurred in 2011 and were declared to the ASN. It discusses the results of measurements of liquid, gaseous and chemical releases from the installations and their impact on the environment. It addresses the radioactive waste management (measures to limit their volume and to limit their impact on health and on the environment, notably on water and soils, type and quantities of wastes stored in INBs). It presents the different measures and actions related to information transparency

  8. Introduction to Cea studies on future nuclear energy systems and safety related research

    International Nuclear Information System (INIS)

    The growth in world energy demand and future prospects of decommissioning of existing power plants stimulate the development of a new generation of nuclear energy systems intended to be more economical, safer and more sustainable. CEA clearly support the idea that nuclear energy has unique assets to be eligible as one of the major energy sources of the sustainable development in terms of natural resources saving, economic competitiveness and public and environmental friendliness, but the possibility of development of nuclear energy is strongly linked with the public acceptance. Public acceptance of nuclear energy depends strongly on safety, and the publics perception of safety. Consequently, a major emphasis for future generations nuclear systems is to improve the safety and the robustness of the technology, and thus the public confidence in safety. (authors)

  9. Incineration as a radioactive waste volume reduction process for CEA nuclear centers

    International Nuclear Information System (INIS)

    Incineration processes represent a promising solution for waste volume reduction, and will be increasingly used in the future. The features and performance specifications of low-level waste incinerators with capacities ranging from 10 to 20 kg-h-1 at the Fontenay-aux-Roses, Grenoble and Cadarache nuclear centers in France are briefly reviewed. More extensive knowledge of low-level wastes produced in facilities operated by the Commissariat a l'Energie Atomique (CEA) has allowed us to assess the volume reduction obtained by processing combustible waste in existing incinerators. Research and development work is in progress to improve management procedures for higher-level waste and to build facilities capable of incinerating α - contaminated waste. (authors). 6 refs., 5 figs., 1 tab

  10. Release monitoring and environmental surveillance of Cea centers. Assessment and regulation and method 1999

    International Nuclear Information System (INIS)

    The quality of the natural environment around the centers of the Commissariat a l Energie Atomique is an important point of its safety policy. The environmental protection is based on the control of risks coming from research and development activities of its installations. It aims to reduce as low as possible, the impact of its activities on man and his environment. This publication develops the sampling and measurement methods that are made on effluents and in environment, according to the radionuclides characteristics, that are present. It gives also the regulation that applied to the effluents monitoring. The results of radioactive effluents releases (liquid and gaseous) and the surveillance of environment around cea centers is given in the 'Bilan 1999' publication. An analysis of these results on the 1995-1999 period allows to follow their evolution. (N.C.)

  11. New high density MTR fuel. The CEA-CERCA-COGEMA development program

    International Nuclear Information System (INIS)

    The development of a new generation of LEU, high in density and with reprocessing capacities MTR fuel, is a key issue to provide reactor operators with a smooth operation which is necessary for a long term development of Nuclear Energy. In the RRFM'98 meeting, a joint contribution of CEA, CERCA and COGEMA presented a technical classification of the potential candidates uranium alloys. In this paper this MTR working group presents the development program of a new high density fuel. This program is composed of three main steps: Basic Data analysis and collection, Plate Tests (Irradiation and Post Irradiation Examinations) and Lead Test Assemblies (Irradiation and Post Irradiation Examinations). The goal to be reached is to make this new fuel available before the end of the present US return policy. (author)

  12. GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)

    CERN Document Server

    Schapira, J P

    1999-01-01

    Nuclear waste partitioning and transmutation (P and T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON (GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented.

  13. GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)

    International Nuclear Information System (INIS)

    Nuclear waste partitioning and transmutation (P and T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON (GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented

  14. GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)

    Science.gov (United States)

    Schapira, J. P.

    1999-07-01

    Nuclear waste partitionning and transmutation (P & T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON ( GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented.

  15. Cea-DSM-DAPNIA-SACM contribution to IFMIF KEP phase June 2000 to December 2002

    International Nuclear Information System (INIS)

    The international fusion materials irradiation facility (IFMIF) requires the generation by a linear accelerator (LINAC) of 250 mA continuous current of deuterons at a nominal energy of 40 MeV. The basic approach is to provide 2 linac modules, each delivering 125 mA to a common target. The accelerators begin with a deuteron ion source and a low-energy beam transport to a radio-frequency quadrupole (RFQ), a buncher and a pre-accelerator up to 5 MeV. The key element technology phase (KEP) was initiated in 2000 with the objective of reducing some key technology risk factors. The IFMIF KEP is carried out at the Cea and it focuses on 5 issues: the ECR source, the 4-vanes RFQ design, the radio-frequency system, the DTL (drift tube linac) design, and high power diagnostics. The present report reviews progress made in the 5 issues quoted above. (A.C.)

  16. The French approach through the SMR consortium (CEA, EDF, AREVA, DCNS)

    International Nuclear Information System (INIS)

    The SMR (Small Modular Reactor) is a new range of nuclear reactors characterized by a low output power (less than 300 MWe) and a standardized modular factory-based construction. Moderate capital costs make this type of reactor very attractive for medium-size power utilities or small countries. A consortium made around the CEA and its industrial partners (EDF, AREVA and DCNS) has performed economic and technical feasibility studies. It appears that the competitiveness of SMR require power production costs around 100 euros/MWh and that SMR will be based on PWR technology with a power output of 150 MWe per unit. 2 types of SMR are proposed: a terrestrial unit and an immersed unit. The concept of the immersed SMR, called Flexblue, is based on an unlimited access to a cold sink (the ocean) and a complete modularity. In both types the standard of safety appears to be high. (A.C.)

  17. Microflora de Bromeliáceas do estado de Pernambuco, Brasil

    Directory of Open Access Journals (Sweden)

    Luis Tavares de Lyra

    1976-01-01

    Full Text Available O autor estudou a microflora de dois gêneros de BROMELIACEAE: Hoenbergia e Portea. As coletas do material foram feitas em seis regiões do Estado de Pernambuco; 1 Região da Mata-Úmida; 2 Região da Mata-Seca; 3 Região do Agreste Central; 4 Região do Agreste Setentrional; 5 Região do Agreste Meridional; 6 Região do Recife. As seguintes diatomáceas indicadoras de águas poluídas (espécies oligossaprobias foram encontradas nas seis regiões estudadas: Gomphonema parvulum (Kutz Grunow., Hantzschia amphioxys Grunow, Pinnularia borealis Ehr., Pinnularia microstauron (Ehr Cleve, gomphonema gracile Ehr., Nitzschia palea Kutz., Melosira roeseana Rabenh., Navicula mutica Kutz., Navicula cryptocephala Kutz., Eunotia pectinalis (Kutz Rabenh. Foram também observadas CHLOROPHYCEAS nas estações chuvosa e seca nas diversas regiões. Algumas são indicadoras de oligossaprobidade: Scenedesmus quadricauda (Turpin brebisson. Chlorococcum sp., Chlorella sp. Os fatores ecológicos e comentários referentes ás diatomáceas foram anotados no texto. A tabela I indica a frequência das diatomáceas nas seis regiões estudadas. Maior número dessas diatomáceas, registramos nas regiões do Agreste. A tabela II mostra a temperatura e pH da água de Hoenbergia e Portea em ambas as estações do ano (inverno e verão. Observamos a ocorrência de larvas de culex em Portea e hoenbergia, entretanto, raramente encontramos larvas de Anopheles. As coletas foram feitas durante as estações chuvosa e seca em Hoenbergia e Portea. Determinamos 35 espécies provenientes de 78 amostras coletadas durante o período de 26 meses.The author studied the microflora from two genera of Bromeliaceae: Hoenbergia and Portea. The material was collected in six natural regions of Pernambuco State: 1 Humid Forest Region; 2 Dry forest region; 3 Central Agreste Region; 4 Setentrional Agreste Region; 5 Meridional Agreste Region; 6 Recife Region. The following diatoms that indicate polluted

  18. Cea-DSM-DAPNIA-SACM contribution to IFMIF KEP phase June 2000 to December 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-05-01

    The international fusion materials irradiation facility (IFMIF) requires the generation by a linear accelerator (LINAC) of 250 mA continuous current of deuterons at a nominal energy of 40 MeV. The basic approach is to provide 2 linac modules, each delivering 125 mA to a common target. The accelerators begin with a deuteron ion source and a low-energy beam transport to a radio-frequency quadrupole (RFQ), a buncher and a pre-accelerator up to 5 MeV. The key element technology phase (KEP) was initiated in 2000 with the objective of reducing some key technology risk factors. The IFMIF KEP is carried out at the Cea and it focuses on 5 issues: the ECR source, the 4-vanes RFQ design, the radio-frequency system, the DTL (drift tube linac) design, and high power diagnostics. The present report reviews progress made in the 5 issues quoted above. (A.C.)

  19. List of reports concerning reactor safety research of BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning special Problems in the field of Reactor Safety Research. According to the cooperation of the Bundesminister fuer Forschung und Technologie (BMFT) with the Commissariat a l' Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these Reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programm of the BMFT, reporting organization. The list of reports appears quarterly. (orig./HP)

  20. New high density MTR fuel. The CEA-CERCA-COGEMA development program

    Energy Technology Data Exchange (ETDEWEB)

    Languille, A. [CEA/DEC Centre de Cadarache, St. Paul lez Durance (France); Durand, J.P. [CEDRCA, ZI les Berauds, Romans (France); Gay, A. [COGEMA/BCR, St. Quentin en Yvelines (France)

    1999-07-01

    The development of a new generation of LEU, high in density and with reprocessing capacities MTR fuel, is a key issue to provide reactor operators with a smooth operation which is necessary for a long term development of Nuclear Energy. In the RRFM'98 meeting, a joint contribution of CEA, CERCA and COGEMA presented a technical classification of the potential candidates uranium alloys. In this paper this MTR working group presents the development program of a new high density fuel. This program is composed of three main steps: Basic Data analysis and collection, Plate Tests (Irradiation and Post Irradiation Examinations) and Lead Test Assemblies (Irradiation and Post Irradiation Examinations). The goal to be reached is to make this new fuel available before the end of the present US return policy. (author)

  1. Overview of CEA studies on advanced Plutonium fuelled PWR core concepts

    International Nuclear Information System (INIS)

    After a brief summary of the French experience of Plutonium recycle in PWRs and a review of the rationale for this strategy, a first part of the paper presents the plans for generalizing the recycling of 30% MOX in present generating facilities and the next generation reactors (EPR). A second part of the paper is dedicated to an overview of CEA studies on advanced 100% MOX PWR core concepts compatible with the EPR design and likely to improve the performances of the reference core design in terms of Plutonium consumption, and minor actinides production. The respective merits of these advanced 100% MOX PWR core concepts are briefly summarized, as well as their potential benefits to accommodate a wide variety of future options for the fuel cycle. (author) 3 figs., 6 tabs., 11 refs

  2. Status of the CNES-CEA joint program on space nuclear Brayton systems

    International Nuclear Information System (INIS)

    A Cooperative program between the French Centre National d'Etudes Spatiales (CNES) and the Commissariat a l'Engergie Atomique (CEA) was initiated in 1983, to investigate the possible development of 20 to 200 kWe space nuclear power systems to be launched by the next version of the European launcher, Ariane V. After completion in 1986 of preliminary conceptual studies of a reference 200 kWe turboelectric power system, an additional 3 year study phase was decided, with the double objective of assessing the potential advantage of nuclear power systems versus solar photovoltaic or dynamic systems in the 20 kWe power range, and comparing various reactor candidate technologies and systems options for 20 kWe space nuclear power systems, likely to meet the projected energy needs of future European space missions. The results of this study are discussed by the authors

  3. TRIPOLI-4®, CEA, EDF and AREVA Reference Monte Carlo Code

    Science.gov (United States)

    2014-06-01

    This paper presents an overview of TRIPOLI-4®, the fourth generation of the 3D continuous-energy Monte Carlo code developed by the Service d'Etudes des Réacteurs et de Mathématiques Appliquées (SERMA) at CEA Saclay. The paper surveys the generic features: programming language, parallel operation, tracked particles, nuclear data, geometry, simulation modes, standard variance reduction techniques, sources, tracking and collision algorithms, tallies, sensitivity studies. Moreover, specific and recent features are also detailed: Doppler broadening of the elastic scattering kernel, neutron and photon material irradiation, advanced variance reduction techniques, Green's functions, cycle correlation correction, nuclear data management and depletion capabilities. The productivity tools (T4G, SALOME TRIPOLI, T4RootTools), the Verification & Validation process and the distribution and licensing policy are finally presented.

  4. The CEA-FRAGEMA ramp test programme for the experimental study of PCI

    International Nuclear Information System (INIS)

    The first phase of the CEA-FRAGEMA ramp test programme which started in 1977 is now terminated. More than twenty-seven fuel rods of PWR type have been ramp tested. Two types of CEA fuel rod design were selected, rods of diameter equal to 8.70 mm with stress relieved Zircaloy 4 claddings and UO2 DCN pellets, rod of diameter typical to 17x17 assembly with recristallysed Zircaloy 4 claddings and UO2 DCI pellets. Except a group of six rods pressurized with 35 bar of Helium, all the rods were pressurized with 1 bar of helium, all the rods were base-irradiated in the BR3 reactor. The burnup ranges are lying between 8 GWd tU-1 and 45 GWd tU-1. An important goal of this programme was also to qualify the FABRICE process which consists in the refabrication of short length rods cut-out from long rods and whose performance during ramp tets have been compared with those of spare rods. The behaviour was quite similar and thus allows to test short rods cut-out from long fuel rods which have been base-irradiated in PWR commercial reactors such as Fessenheim, Bugey or CAP. After recalling the main characteristics of the ramp tested fuel rods and the irradiation conditions the paper presents an overview of the ramp test results and emphasizes the results obtained by Eddy Current tests and confirmed by metallographic examinations which lead to define an interaction zone expressed in terms of local linear heat rating, and burnup. The SCC was found to be the governing phenomenon which led to PCI failures. The influence of burnup, maximum linear heat-rating, initial power or power step is demonstrated, the influence of initial internal pressurization is established at least at burnup greater than 40 GWd tU-1. PCI failure thresholds are established and compared with other limits given in the open literature. (author)

  5. Colecta y establecimiento de anonáceas en El Salvador

    Directory of Open Access Journals (Sweden)

    Eduardo Cruz

    2000-01-01

    Full Text Available El Centro Nacional de Tecnología Agropecuaria y Forestal (CENTA, a través de la Unidad de Recursos Fitogenéticos, inició en 1998 un diagnóstico geográfico de especies de anonáceas, con el objetivo de explorar, recolectar, caracterizar y establecer colecciones de campo en las Estaciones Experimentales. Las características evaluadas para frutos fueron: peso, largo y diámetro, número de semillas, textura de cáscara y pulpa; forma de fruto y cárpelos, daño por plagas y enfermedades y un análisis bromatológico. Como resultado de este trabajo se estableció la colección de anonáceas con las siguientes especies: squamosa, cherimola, reticulata, muricata, purpurea, diversifolia, holosericea y glabra. En la caracterización morfológica preliminar Annona muricata obtuvo un promedio de 175 semillas/fruto y 1,319 g en peso del fruto. A. cherimola con pulpa muy arenosa y carpelos no prominentes. A. squamosa con pulpa dulce, blanca y cárpelos muy prominentes. De la caracterización bromatológica se determinó que Annona muricata dio contenidos de humedad superiores a 82,8%; fibra cruda de 1,84% y fósforo con 367 ppm. En Annona diversifolia con menor grasa 0,01%. La mayor incidencia por plagas en frutos y semillas fue causado por el perforador Bephrateloides sp. La antracnosis (Colletotrichum sp. en frutos y follaje fue la enfermedad más observada

  6. Overview of CEA studies on hydrogen production and related prospects for nuclear power

    International Nuclear Information System (INIS)

    The anticipated growth of the world energy demand and the increasing concern about the emission of greenhouse gases, with the objectives of limitation fixed by the Kyoto protocol, prepare the ground for the development of hydrogenous fuels, and especially that of hydrogen as energy carrier. The trend will be reinforced in the longer term with the progressive shortage of natural hydrocarbon fuels. Fuel cells used in stationary, transport and portable applications will probably be the most efficient hydrogen converter and the most promising decentralized energy technology of the next decades. In order to contribute to the reduction of greenhouse gas emissions, a massive use of hydrogen for transport and stationary applications calls for the development of production processes compatible with low CO2 emissions, thus limiting the use of fossil fuels (natural gas, oil, coal...) as reagent or energy sources. Furthermore, the progressive exhaustion of economic fossil fuel reserves will ultimately make it necessary to extract hydrogen from water through CO2 free processes. With this prospect in view, base-load nuclear energy, besides renewable energies, can play an important role to produce hydrogen through electrolysis in the medium term, and also through high temperature thermochemical water dissociation processes in the longer term. Starting from current research in the field of fuel cans and hydrogen storage systems, the CEA intends to implement a large R and D programme on hydrogen also covering the aspects of production, transport and related safety requirements. This endeavour is intended to reinforce the contribution of the CEA to the national and European research effort on non-fossil energy sources, and to open new opportunities of international collaborations and networking. (authors)

  7. Immunoscintigraphy of CEA-expressing cancers with complete and fragmented monoclonal antibodies: indications, chances and limits

    International Nuclear Information System (INIS)

    CEA-expressing cancers belong to the most frequent malignant diseases of the western world. The early recognition of tumor recurrence or metastasis, respectively, is probably the key to an improvement of the patient's prognosis. Conventional radiological procedures are characterized by their limited sensitivity and specificity; therefore, complementary methods, such as immunoscintigraphy, are warranted. In Europe, essentially three monoclonal anti-CEA antibodies, which can be directly labeled with technetium (complete IgG of the clone BW431/26, as well as the fragments F023C5 and IMMU-4), are in clinical use. Complete IgG is burdened by slow tumor targeting kinetics and a slow background clearance. This makes its diagnostic use with short-lived isotopes difficult. Fragments are able to targert more quickly but express some metabolic instability, as well as a high renal accretion. Fragments have shown higher sensitivities in the detection of liver metastases and local recurrences, two of the most important sites of tumor relapse. In contrast to IgG, diagnosis is usually possible as early as after 4-6 h p.i. Thus, different indications for the use of IgG or fragments result, and, in the individual case, also complementary studies with both may be indicated. Whereas 30% of patients develop HAMA after a single administration of IgG, the HAMA incidence of fragments is, with less than 1%, dramatically lower, even in the case of repeated administrations. Future studies with humanized antibodies, smaller 'molecular recognition units', or the development of stable bivalent fragment with technetium label will show whether further improvements of the diagnostic accuracy are possible. (orig.)

  8. Gnatophyma: a rare form of rosacea Gnatofima: uma forma rara de rosácea

    Directory of Open Access Journals (Sweden)

    Ana Carolina Lisboa de Macedo

    2012-12-01

    Full Text Available Phyma is the last stage of rosacea and is due to chronic inflammation and edema. It can affect nose (rhinophyma, chin (gnatophyma, forehead (metophyma, ears (otophyma and eyelids (blepharophyma. Rhinophyma is the most frequent location and there are few reports about gnatophyma. We report the case of a female patient, 41 years old, who had an infiltrated, erythematous, edematous plaque around the chin and lower lip for two years. Histopathology showed perivascular lymphocytic infiltrate, hypertrophied follicles and sebaceous glands, dilated vessels and fibrosis. She was treated with oral tetracycline, oral ivermectin and metronidazole cream with a satisfactory response. The clinical, histopathological and therapeutic response correlation confirmed the diagnosis of gnatophyma, a rare variant of phyma.Fima é o estágio final da rosácea e ocorre devido ao edema e inflamação crônica. Pode acometer nariz (rinofima, mento (gnatofima, fronte (metofima, orelhas (otofima e pálpebras (blefarofima. Rinofima é a localização mais encontrada e há raros relatos de gnatofima. Relataremos paciente feminina, 41 anos, que apresentava placa infiltrada, eritêmato-edematosa, em todo o mento e lábio inferior há dois anos. Histopatológico com infiltrado linfocitário perianexial e perivascular, folículos e glândulas sebáceas hipertrofiadas, vasos ectasiados e fibrose perianexial. Foi instituído tratamento com tetraciclina via oral, ivermectina via oral e metronidazol creme com resposta satisfatória. Através da correlação clínica, histopatológica e resposta terapêutica confirmou-se o diagnóstico da variante rara de fima, gnatofima.

  9. Las Podocarpáceas de los bosques montanos del noroccidente peruano

    Directory of Open Access Journals (Sweden)

    Edgar E. Vicuña-Miñano

    2013-05-01

    Full Text Available Los bosques montanos del noroccidente peruano son formaciones vegetales que presentan una alta diversidad y endemismos. Lamentablemente, en muchos lugares están sujetos a procesos acelerados de deterioro por la deforestación y colonización, aspecto que los convierte en uno de los ecosistemas más amenazados por el hombre. Lo que ahora queda de estos bosques, alguna vez extensos, son sólo fragmentos. Los bosques montanos relictos son ecosistemas ubicados por encima de los 1000 m de altitud, en la Vertiente Occidental de los Andes. Es en estos bosques, donde se pueden encontrar especies de coníferas nativas de nuestro país, pertenecientes a la familia Podocarpaceae. Estas especies juegan un rol de suma importancia en la dinámica de estos ecosistemas tan frágiles; no obstante, debido a la calidad de sus maderas, están siendo extraídas de manera alarmante. En el noroccidente peruano existen zonas de bosques homogéneos de Podocarpáceas tal es el caso del bosque de Cachil en la provincia de Contumazá, bosque de TongodQuellahorco en la provincia de San Miguel (en los cuales predomina la especie Podocarpus oleifolius y los bosques de San Ignacio en Cajamarca, en los que reportamos cinco especies de Podocarpáceas distribuidas en tres géneros: Podocarpus (P. oleifolius, P. macrostachys, P sprucei, Prumnopitys (P. harmsiana y Nageia (N. rospigliosii, las cuales representan el 50% del total de especies reportadas para el Perú.

  10. Annual report of the Association EURATOM/CEA 2003 (executive summary)

    International Nuclear Information System (INIS)

    3 different materials (copper base, stainless steel and mono-crystalline molybdenum) have been selected for mirrors used in diagnostic purposes. A new diagnostic for thermographic analysis has been developed for JET. The EURATOM-Cea association is involved in the development of the first ITER neutral beam injector (in particular the source and the accelerator) and in the design of the ITER neutral beam test facility. The EURATOM-Cea association has contributed to the design of an ITER-relevant ICRH launcher that will be installed on JET during the 2004 shutdown. The development of an industrial cutting and welding laser tool for fabrication and maintenance of hydraulic connector parts of the ITER blanket module has been achieved in 2003. Work on the manufacture of the ITER primary first wall panel by HIP forming is ongoing. In the field 'plasma facing components' activities have focused on flat tile technology and particularly on the possibility of failure in cascade of these tiles. A full-scale prototype mock-up of the ITER divertor vertical target has been high flux tested. The hot isostatic pressing technique has been selected for the fabrication of lot of fusion reactor components. Concerning remote handling activities, the feasibility studies for the remote maintenance (cutting, welding and inspection) of the ITER divertor cooling pipe with bore tools have been achieved. In the field 'magnet', activities have focused on an extensive characterization of 3 types of NbTi strand candidate for ITER PF coils and on the thermohydraulic properties of cable-in-conduit conductors. The helium cooled lithium lead (HCLL) breeding blanket concept has been developed for the test blanket module. In the field 'structural materials', work has been dedicated to the development of reduced activation ferritic martensitic steel and of SiC-SiC ceramic composites and of tungsten alloys. In the framework of fusion waste management, different processes that could be used for tritium

  11. 3-month GPS subsidence analysis in North Sea, ELF/CEA-LDG interpretation

    International Nuclear Information System (INIS)

    The authors process and analyze 3 months of continuous GPS offshore data provided by the operator from 10 single-frequency stations in the Ekofisk field in the north Sea for subsidence monitoring. This analysis is done using the Differential-GPS automatic software and method developed by the EAP/CEA-LDG. The mean subsidence rates obtained by the EAP/CEA method shows, over these three months, a maximum rate at the center of the subsidence of about 30 mm/month bowl in agreement with previous determinations. The accuracy of the results can be improved by smoothing techniques. However, the noise is still directly related to the distance between the monitored point and the reference points. For instance, the daily averages lead to an accuracy (root mean squares = r.m.s) of 1.1, 1.4 and 2.4 mm for the East, North and Vertical components of the movements for a 2 km baseline and 1.8, 3.7 and 3.8 mm for the East, North and Vertical components for a 24 km baseline. The choice of the best reference points in the network is discussed. Horizontal measurements are simultaneously detected and may be due either to platform tilt or to sea-bed horizontal movements. A further analysis (the 2-hours method) indicate that the noise in the results has a periodic daily structure. In addition, results from previous calibration experiments are used in the method to test the result quality, processed data interpretation

  12. Perioperative cerebral ischemic complications after carotid endarterectomy without shunting. A series of 400 consecutive CEA evaluated by intraoperative monitoring and post-operative diffusion-weighted imaging

    International Nuclear Information System (INIS)

    The use of intraluminal shunting during carotid endarterectomy (CEA) remains controversial. From January 2001 to September 2010, 400 CEAs without shunting were performed under general anesthesia by 14 neurosurgeons (2 consultants, 12 trainees). We used electroencephalography (EEG) and somatosensory evoked potential (SEP) to monitor under selective burst suppression using barbiturate or propofol administration during cross-clamping. In 66 of the 400 CEAs (16.5%), intraoperative monitoring demonstrated abnormalities after cross-clamping. In 26 (6.5%) of the 400 CEAs, new areas of diffusion hyperintensity were identified postoperatively. Within 30 days, the combined mortality and morbidity (symptomatic ischemia) rate was 2.8%. Thirteen (3.3%) patients presented with TIA. CEA without shunting can be safely performed with EEG and SEP monitoring under induced hypertention and selective burst suppression. (author)

  13. Localization of 131Ilabeled goat and primate anti-carcinoembryonic antigen(CEA) antibodies in patients with cancer

    International Nuclear Information System (INIS)

    Thirty patients with anti-carcinoembryonic antigen (CEA)-producing cancers of the colon, breast, or thyroid were intected with 1 to 2 mCi of Iodine-131 (131I)-labeled, affinity-purified, goat or baboon anti-CEA antibodies. Images were obtained daily for four days. Computerized background subtraction using technetium 99m (99mTC)-labeled compounds was used. Images obtained with and without background subtraction were correlated with other evidence of disease. Activity levels in plasma, urine, and thyroid gland were monitored. Significant deiodination of antibody occurred within the first 24 hours. The mean plasma half-disappearance-time of baboon antibody was significantly longer than the mean half-disappearance-time of goat antibody. With exogenous blockade, total thyroid uptake was less than 0.1% of the injected dose. Without background subtraction, scintigraphic localization of known tumor was possible in one of two patients with colon carcinoma, in three of 20 patients with breast cancer, and in one of five patients with medullary carcinoma of the thyroid. With background subtraction, potential false-positive results could be generated for every patients, depending on the normalization site chosen and the degree of subtraction used. In contrast to results of previous reports, CEA-producing tumor was found to be infrequently localized using highly purified goat or primate radiolabeled anti-CEA. Furthermore, the subtraction technique described by previous investigators may lead to a high false-positive rate

  14. Serum tumor marker CYFRA 21-1 in the diagnostics of squamous cell lung cancer - comparison with CEA

    International Nuclear Information System (INIS)

    The aim of the study was to test the diagnostic value tumor marker CYFRA 21-1 for squamous cell lung cancer (SQCLC) in comparison with carcinoembryonic antigen (CEA). Ninety-one patients were induced in this study: 56 with SQCLC - Group I, 25 with other types of lung cancer - Group II, 10 with benign respiratory tract diseases - Group III. Median CYFRA 21-1 serum concentration (ng/ml) was: in Group I: 4.52 (0.94 - >16), in Group II: 3.58 (1.72 - >16), in Group III: 2.05 (0.99 - 3.41). Median CEA serum concentration (ng/ml) was: in Group I: 4.49 (076- >20), in Group II: 3.32 (1.17 - >20), in Group III: 3.09 (1.84 - 6.37). There was a highly significant difference between the levels of CYFRA 21-1 in group I and Group III (p < 0.001), but there was no statistically significant difference between the levels of CEA in Group I and III. Sensitivity of CYFRA 21-1 by the cut-off 3.33 ng/ml in the diagnostics of SQCLC was 0.68, specificity 0.090, positive predictive value 0.91, negative predictive value 0.65. Sensitivity of CEA by cut-off 4.61 ng/ml was 0.5 by the same specificity 0.90. CYFRA 21-1 has high sensitivity, specificity and positive predictive value in the diagnostics of SQCLC. Sensitivity of CYFRA 21-1 is significantly higher than sensitivity of CEA in this settings. (author)

  15. A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma

    International Nuclear Information System (INIS)

    Objectives: To assess the prognostic value of combined evaluation of preoperative CT findings and pre/postoperative serum carcinoembryonic antigen (CEA) levels for pathological stage I lung adenocarcinoma. Methods: This retrospective study included 250 consecutive patients who underwent complete resection for ≤3-cm pathological stage I (T1–2aN0M0) adenocarcinomas (132 men, 118 women; mean age, 67.8 years). Radiologists evaluated following CT findings: maximum tumor diameter, percentage of solid component (%solid), air bronchogram, spiculation, adjacency of bullae or interstitial pneumonia (IP) around the tumor, notch, and pleural indent. These CT findings, pre/postoperative CEA levels, age, gender, and Brinkman index were assessed by Cox proportional hazards model to determine the best prognostic model. Prognostic accuracy was examined using the area under the receiver operating characteristic curve (AUC). Results: Median follow-up period was 73.2 months. In multivariate analysis, high %solid, adjacency of bullae or IP around the tumor, and high postoperative CEA levels comprised the best combination for predicting recurrence (P < 0.05). A combination of these three findings had a greater accuracy in predicting 5-year disease-free survival than did %solid alone (AUC = 0.853 versus 0.792; P = 0.023), with a sensitivity of 85.7% and a specificity of 74.3% at the optimal threshold. The best cut-off values of %solid and postoperative CEA levels for predicting high-risk patients were ≥48% and ≥3.7 ng/mL, respectively. Conclusion: Compared to %solid alone, combined evaluation of %solid, adjacency of bullae or IP change around the tumor, and postoperative CEA levels improves recurrence prediction for stage I lung adenocarcinoma

  16. A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Yamazaki, Motohiko, E-mail: xackey2001@gmail.com [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Ishikawa, Hiroyuki [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Kunii, Ryosuke [Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Tasaki, Akiko; Sato, Suguru; Ikeda, Yohei; Yoshimura, Norihiko [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Hashimoto, Takehisa; Tsuchida, Masanori [Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences (Japan); Aoyama, Hidefumi [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan)

    2015-01-15

    Objectives: To assess the prognostic value of combined evaluation of preoperative CT findings and pre/postoperative serum carcinoembryonic antigen (CEA) levels for pathological stage I lung adenocarcinoma. Methods: This retrospective study included 250 consecutive patients who underwent complete resection for ≤3-cm pathological stage I (T1–2aN0M0) adenocarcinomas (132 men, 118 women; mean age, 67.8 years). Radiologists evaluated following CT findings: maximum tumor diameter, percentage of solid component (%solid), air bronchogram, spiculation, adjacency of bullae or interstitial pneumonia (IP) around the tumor, notch, and pleural indent. These CT findings, pre/postoperative CEA levels, age, gender, and Brinkman index were assessed by Cox proportional hazards model to determine the best prognostic model. Prognostic accuracy was examined using the area under the receiver operating characteristic curve (AUC). Results: Median follow-up period was 73.2 months. In multivariate analysis, high %solid, adjacency of bullae or IP around the tumor, and high postoperative CEA levels comprised the best combination for predicting recurrence (P < 0.05). A combination of these three findings had a greater accuracy in predicting 5-year disease-free survival than did %solid alone (AUC = 0.853 versus 0.792; P = 0.023), with a sensitivity of 85.7% and a specificity of 74.3% at the optimal threshold. The best cut-off values of %solid and postoperative CEA levels for predicting high-risk patients were ≥48% and ≥3.7 ng/mL, respectively. Conclusion: Compared to %solid alone, combined evaluation of %solid, adjacency of bullae or IP change around the tumor, and postoperative CEA levels improves recurrence prediction for stage I lung adenocarcinoma.

  17. Technical report on the fatigue crack Growth Benchmark based on CEA pipe bending tests

    International Nuclear Information System (INIS)

    In order to improve the estimation methods of surface crack propagation through the thickness of components, CEA has proposed a benchmark to members of the IAGE WG, sub-group on Integrity of metal components and structures. The subject is a simple configuration of a pipe containing an axisymmetric notch and submitted to a cyclic bending load. An experimental data-set form CEA was used to validate three issues in the topic of Leak Before Break. - Crack initiation, - Crack propagation through the thickness, - Crack penetration. All material and geometrical data which are necessary for the simulation were given in the proposal, including experimental results. Due to the peculiar complexity of the problem, it was decided to focus the work on methodologies comparison so as to allow participants to tune up parameters and adjust their models and tools. This report presents all estimations performed by the participants and collected by CEA. They are compared to the experimental results. An analysis of the used procedures is also proposed. This, associated with the study of the accuracy of different methodologies, leads to comments and recommendations on the analysis of fatigue crack growth. The participation in the first step was important: nine participants have proposed analyses, sometimes parametric analysis to estimate crack growth. Results sorted out three estimation methods groups that give results in accordance with experimental ones (these three groups are based on a strain range evaluation and the fatigue curve of the material): - The use of an elastic stress at the notch tip and a fatigue notch concentration factor to determine the strain range. - The use of a KI (or elastic F.E. calculation) and a Neuber rule for the estimation of the strain range at a characteristic distance from the crack tip. - The direct calculation of the strain range at the characteristic distance by an elastic plastic F.E. calculation. Only 4 participants have proposed an estimate of the

  18. Nuclear energy for the future: CEA strategic R and D orientations

    International Nuclear Information System (INIS)

    Worldwide energy consumption is expected to double over the next 50 years. If there is no major change in the trend, this growth should quickly cause depletion of fossil fuel resources, a dramatic increase in the contents of greenhouse effect gases and a serious supply risk for many countries. Beyond energy savings and the development of renewable energies, nuclear energy can provide a sustainable solution to these increased needs. This is the context in which the CEA is developing its nuclear R and D strategy for the future. One objective is to optimize and develop the current nuclear facilities : R and D for nuclear energy should increase the competitiveness of existing nuclear facilities, further improve safety. Water reactors (PWR and BWR), based on design principles that are now almost 40 years old, have been improved over time, but also made more complex due to increasing safety requirements, and more powerful through economic optimization. Enriched uranium fuels are safe and reliable. Pressurized water reactors are expected to become even more competitive in time with the new reactor designs (EPR) and the life extension of existing power stations. Nuclear energy sustainable development will only succeed with public acceptance. Solutions to Plutonium inventory management (see paper nr. 665) must be provided by either using it in fast neutron reactor where it as the most energy production efficiency or burning it out in existing - or future - PWR. Another objective is to bring efficient and acceptable solutions for HLLL waste management (see paper nr. 666) and reinforce knowledge on health and environment impact of nuclear activities. The third objective is to prepare and assess new generations of nuclear energy systems. Water reactors only consume 1% of the initial natural uranium and irradiated fuels still contain 96% of energetic material ; they also have a limited turbine efficiency. Industrial fast neutron reactors have been built. These reactors have

  19. Spanish pre-university students' use of English: CEA results from the University Entrance Examination

    Directory of Open Access Journals (Sweden)

    María Belén Díez Bedmar

    2011-12-01

    Full Text Available In this paper an updated overview of the main errors that Spanish students make when writing the English exam in the University Entrance Examination is provided. To do so, a Computer-aided Error Analysis (CEA (Dagneaux, Denness & Granger, 1998 was conducted on a representative sample of the students who took the exam in June 2008 in Jaén, and wrote a composition on the same topic. The use of the most widely-used error taxonomy, the Error Tagging Manual version 1.1. (Dagneaux, Denness, Granger & Meunier, 1996, and the analysis of the results by means of descriptive statistics foster the possibility to replicate this study and move forward in the description of the students’ written command in the foreign language at this stage. The comparison of the findings obtained in this study and those from previous (CEAs on the English exam reveals that some common tendencies may be shown.Este artículo aporta una visión general actualizada de los errores más importantes que los alumnos españoles cometen cuando escriben el examen de inglés de la Prueba de Acceso a la Universidad. Con este fin, se realizó un Análisis de Errores Informatizado (Dagneaux, Denness & Granger, 1998 en una muestra representativa de los estudiantes que realizaron el examen en Junio de 2008 en la Universidad de Jaén, y que escribieron sobre un mismo tema. El uso de la taxonomía de errores más usada, el Error Tagging Manual version 1.1. (Dagneaux, Denness, Granger & Meunier, 1996, y de la estadística descriptiva para analizar los resultados, favorecen la réplica de este estudio y la posibilidad de mejorar la descripción de la destreza escrita en la lengua extranjera. La comparación de los resultados en este artículo y otros Análisis de Errores (Informatizados previos muestran que se pueden exponer algunas tendencias comunes.

  20. Experimental study of biotin-avidin pretargeting technique for anti-CEA McAb radioimmunoimaging

    International Nuclear Information System (INIS)

    Biotin-avidin pretargeting technique was used in promoting the diagnostic efficacy of anti-CEA McAb radioimmunoimaging. CEA McAb was conjugated with biotin McAb (B-McAb), streptavidin (SA) was labeled with 131I (131I-SA) and DTPA-biotin with 111In(111In-DTPA-B). Experimental human colonic tumor bearing nude mice were used. Two step method: B-McAb was preinjected, followed by 131I SA 48h later, 24, 48, 96 and 120 h postinjection, γ-imaging and biodistribution were studied. Three step method: B-McAb was preinjected, followed by cold SA 24h later and 111In-DTPA-B another 24h later. 2,6,24 and 48h postinjection, γ-imaging and biodistribution were also studied. Two step method: T/NT of all organs in experimental group was significantly increased compared with controls. The blood T/NT in experimental group and control group at 24 and 120h was 1.11:0.42 and 8.58:3.51, respectively. Tumor % ID/g in all organs slightly decreased compared with direct group. In γ-imaging radioactivity has been accumulated in tumor site as early as 24h, while only slightly visualized or non-visualized in controls. Three step method: in experimental group the blood T/NT reached 4.19 at 2 h, whereas all was < 1.37 at each phase of controls, the T/NT of all organs was also higher in experimental grouped than in controls. The tumor % ID/g in experimental group was 9.72% at 2h and 3.65% at 48h whereas % ID/g in controls in all phases was <3.07. The tumor clearly visualized at 2h and clearer at 48h in γ-imaging. In controls, the tumor was slightly visualized also to early stage, but faded away later on. Biotin-avidin pretargeting technique can elevate the T/NT ratio and decrease the blood background. Early imaging was obtained with better imaging quality

  1. 2004 annual report. Defense, safety, energy, information, health. CEA in the center of big European challenges; Rapport annuel 2004. Defense, securite, energie, information, sante. Le CEA au coeur des grands defis europeens

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This document is the 2004 annual report of the French atomic energy commission (CEA). It presents the R and D activities of the CEA in three main domains: 1 - defense and safety, maintaining perenniality of nuclear dissuasion and nuclear safety: supplying nuclear weapons to armies, maintaining dissuasion capability with the simulation program, sharing R and D means with the scientific community and the industrial world, designing and maintaining naval nuclear propulsion reactors, cleansing Marcoule and Pierrelatte facilities, monitoring treaties and fighting against proliferation and terrorism; 2 - energy, developing more competitive and cleaner energy sources: nuclear waste management, optimization of industrial nuclear activities, future nuclear systems and new energy technologies, basic research on energy, radiobiology and toxicology; 3 - information and health, valorizing industry thanks to technological research and supplying new tools for health and medical research: micro- and nano-technologies, software technologies, basic research for industrial innovation, nuclear technologies for health and bio-technologies. (J.S.)

  2. Selection of aptamers to Anti-CEA%癌胚抗原特异性单克隆抗体(Anti-CEA)核酸适配体的筛选

    Institute of Scientific and Technical Information of China (English)

    曾家豫; 万波; 马瑾; 袁红霞; 李星; 赵运旺; 廖世奇

    2015-01-01

    目的:筛选癌胚抗原(carcinoembryonic antigen,CEA)特异性单克隆抗体(Anti-CEA)的核酸适配体(aptamers),为肺癌血清肿瘤标志物核酸适配体的筛选奠定实验基础.方法:利用羧基化琼脂磁珠作为筛选介质,以Anti-CEA为筛选的目标靶分子,通过消减SELEX技术及实时定量PCR技术,从随机ssDNA文库中筛选出与Anti-CEA特异性结合的aptamers,并通过凝胶阻滞实验(EMSA)鉴定筛选到的Anti-CEA-aptamer复合物,然后将得到的第10轮富集文库扩增为双链DNA,通过切胶纯化后,连接PMD18-T载体,转化大肠杆菌DH5α感受态细胞,同时利用交错PCR技术鉴定阳性克隆,经测序,获得aptamers的序列.结果:经过10轮筛选得到了4条与Anti-CEA结合的aptamers,测序结果显示均为不同序列.结论:验证筛选出的与Anti-CEA结合的aptamer,特异性检测结果表明2号aptamer与靶分子结合的特异性很高,且与非特异蛋白无明显吸附,筛选出的aptamers用于识别Anti-CEA,将为肺癌的早期诊断和早期治疗提供新的突破口.

  3. Cea assessment of the sulphur-iodine cycle for hydrogen production

    International Nuclear Information System (INIS)

    The sulphur-iodine cycle is a promising process for hydrogen production using nuclear heat: - it is a purely thermochemical cycle, implying that hydrogen production will scale with volume rather than surface; - it only involves fluids, thus avoiding the often difficult handling of solids; - its heat requirements are well matched to the temperatures available from a Generation IV very/high temperature reactor. These characteristics seem very attractive for high efficiency and low cost massive hydrogen production. On the other hand, the efficiency of the cycle may suffer from the large over-stoichiometries of water and iodine and the very important heat exchanges it involves; furthermore, due to lack of adequate thermodynamic models, its efficiency is difficult to assess with confidence. Besides, the large quantities of chemicals that need to be handled, and the corrosiveness of these chemicals, are factors not to be overlooked in terms of investment and operation costs. In order to assess the actual potential of the sulphur-iodine cycle for massive hydrogen production at a competitive cost, CEA has been conducting an important programme on this cycle, ranging from thermodynamic measurements to hydrogen production cost evaluation, with flow sheet optimisation, component sizing and investment cost estimation as intermediate steps. The paper will present the method used, the status of both efficiency and production cost estimations, and discuss perspectives for improvement. (authors)

  4. Report on transparency and nuclear safety - Fontenay-aux-Roses CEA centre - 2012

    International Nuclear Information System (INIS)

    This report presents the different nuclear base installations (INB) of the Fontenay-aux-Roses CEA centre, gives an overview of measures regarding safety within these installations (organisation, general arrangements, arrangements related to different risks, defence in-depth, management of emergency situations, inspections, audits and second-level controls, arrangements and main events specific to the different installations and buildings, issues related to transports, soil radiological assessment) and measures related to radiation protection (organisation and results). It reports the significant events related to safety and radiation protection which occurred in 2012 and were declared to the ASN, and discusses how the return-on-experience has been used. It reports and comments the results of measurements of radiological and chemical gaseous and liquid effluents, of surveys of the environment. It also evokes important events related to these measurement and survey processes, presents the environmental management approach. The next part addresses the management of radioactive wastes: arrangements aimed at limiting the volume of warehoused wastes, and at limiting their impact on health and on the environment, nature and quantities of warehoused wastes. The different arrangements regarding transparency and information are reviewed (TSN report, newsletter, and so on)

  5. Meeting of Directors and Heads of Department from CEA-Saclay, France

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Directors and Heads of Department from the Saclay centre of the French atomic energy commission (CEA) visited CERN in December. They are pictured here at the LHC magnet test facility in building SM18. On the left behind the visitors are the test benches where magnets are prepared for installation in String 2: the 120-metre full-scale model of an LHC cell of the regular part of the arc, which can be seen to the right. Photos 01, 02: Left to right: Marc Dejardin, Alain Givernaud, Louis Laurent, François Kircher, Antoine Masurel, Joël Feltesse, André Menez, T. Taylor, Philippe Pradelles, Bernard Sevestre, Michel Roche, Jean-Yves Gascoin, Thierry Lieven, Michel Spiro, Jean-Pierre Pervès, Yves Lemoigne, Béatrice Reder, Georges Carola, Philippe Lebrun, Yves Bourlat, Bertrand Mercier, Jean-Paul Langlois, Patrick Laurent, Didier Moulin, Xavier Vitart, Marc Serre, Jean-Louis Pierrey, Patrick Jarry, Bruno Mansoulié, Stéphane Lequien, Hervé Barbelin, Philippe Pallier, Jean-Yves Guillamot, and Norbert Sioegel.

  6. Status of CEA reactor studies for a 200 kWe turboelectric Space Power System

    International Nuclear Information System (INIS)

    A reference design for a 200 kWe Space Nuclear Power System has been developed by the CNES and CEA Agencies of the French Government in order to assess within a first study phase running from mid 1984 to mid 1986, the key feasibility issues and the development cost of a Space Power System compatible with the version of the European launcher (ARIANE V), that will be available after 1995, and with adequate power range and lifetime performances for the missions considered at that time. The heat from a fast spectrum lithium cooled reactor is converted by a turboelectric system, selected for its technological readiness and for its advantage over thermionics and thermoelectricity, of minimizing the total mass of 100 to 300 kWe power systems, considering the available radiator area afforded by the specific ARIANE V geometrical features. A heat pipe radiator is preferred to an equivalent gas cooled system, for the increased reliability brought by the large number of independent cooling elements. The successive topics addressed in the paper, include a description of the system main components and steady state operating conditions, and the present views about the start up procedure and the reactor control

  7. Status of the CNES-CEA joint program on space nuclear Brayton systems

    International Nuclear Information System (INIS)

    A cooperative program between the French Centre National d'Etudes Spatiales (CNES) and the Commissariat a l'Energie Atomique (CEA) was initiated in 1983, to investigate the possible development of 20 to 200 kWe space nuclear power systems to be launched by the next version of the European launcher, Ariane V. After completion in 1986 of preliminary conceptual studies of a reference 200 kWe turbo-electric power system, an additional 3 year study phase was decided, with the double objective of assessing the potential advantage of nuclear power systems versus solar photovoltaic or dynamic systems in the 20 kWe power range, and comparing various reactor candidate technologies and system options for 20 kWe space nuclear power systems, likely to meet the projected energy needs of future European space missions. A comprehensive program including conceptual design studies, operating transient analyses and technology base assessment, is currently applied to a few reference concepts of 20 kWe nuclear Brayton and thermoelectric systems, in order to establish sound technical and economical bases for selecting the design options and the development strategy of a first space nuclear power system in Europe

  8. Status of CEA reactor studies for a 200 kWe turbo electric space power system

    International Nuclear Information System (INIS)

    The present European ARIANE space program will expand after 1995 in the development of the large ARIANE 5 launch vehicle. Considering, that the range of power needs (50 to 400 kWe) and operation times required for the space missions planned after the year 2000, are relevant to a nuclear power system, the French Centre National d'Etudes Spatiales (CNES) invited in 1983 the Commissariat a l'Energie Atomique (CEA) to undertake preliminary studies on space power systems. The purpose of the present two year phase (mid 1984-mid 1986) is to identify key technologies for a space generator within the power range of interest and to estimate the development cost of such a project to be examined for commitment in 1986. This work mainly consists in the feasibility and cost assessment of a reference 200 kWe turboelectric space generator, selected for the maturity and availability of the conversion system and for its attractive specific mass compared to thermionics and thermoelectricity, considering the available radiator area afforded by the specific ARIANE 5 geometrical features. The system is basically composed of a fast neutron spectrum lithium cooled reactor, of a Brayton conversion loop and of a heat pipe radiator

  9. Enxertia herbácea em Myrtaceae nativas do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Daiane Silva Lattuada

    2010-12-01

    Full Text Available O objetivo deste trabalho foi testar a viabilidade da técnica de enxertia herbácea em frutíferas nativas da família Myrtaceae. O experimento foi realizado em casa de vegetação do Departamento de Horticultura e Silvicultura/ UFRGS, em Porto Alegre. Duas espécies de Myrtaceae nativas foram usadas, tanto como porta-enxerto quanto como enxerto, Eugenia uniflora (Pitangueira e E. involucrata (Cerejeira-do-rio-grande ou Cerejeira-do-mato, totalizando quatro combinações. O método de enxertia adotado foi por garfagem em fenda cheia, em ramos herbáceos, com diâmetro médio do porta-enxerto de 0,1cm, enquanto os ramos dos enxertos apresentavam diâmetro médio entre 0,08 a 0,1cm, para as duas espécies. As análises foram quinzenais e, após 70 dias, foram analisadas estatisticamente a pega e a altura média das brotações emitidas. O delineamento experimental foi o completamente casualizado, com quatro repetições, sendo cada unidade experimental composta de cinco enxertos. Os resultados indicaram pega de 60% na combinação Pitangueira-Pitangueira (porta enxerto - enxerto. As demais combinações mostraram-se ineficientes.

  10. Light ion source for proton/deuteron production at CEA Saclay for the Spiral2 project

    International Nuclear Information System (INIS)

    The production of rare radioactive ion beam (RIB) far from the valley of stability is one of the final purposes of the Spiral2 facility in Caen. The RIB will be produced by impinging a deuteron beam onto a carbon sample to produce a high neutron flux, which will interact with a uranium target. The primary deuteron beam is produced by an ion source based on ECR plasma generation. The deuteron source and the low energy beam transport (LEBT) has been assembled and tested at CEA Saclay. Diagnostics from other laboratories were implemented on the LEBT in order to characterize the deuteron beam produced and compare it to the initial simulations. The ion source has been based on a SILHI-type source, which has demonstrated good performances in pulsed and continuous mode, and also a very good reliability on long term operation. The 5 mA of deuteron beam required at the RFQ entrance is extracted from the plasma source at the energy of 40 kV. After a brief description of the experimental set-up, this article reports on the first beam characterization experiments.

  11. Training and Certification Program for Certified Energy Auditors (CEA) and Certified Building Commissioning Professionals (CBCP)

    Energy Technology Data Exchange (ETDEWEB)

    Kent, Bill

    2012-08-24

    The Association of Energy Engineers (AEE) has offered energy efficiency training and certification programs for over 30 years. During that time AEE has certified more than 22,000 professionals. All of our certification programs are the result of extensive industry research and program development and oversight by certification boards. For this project award, AEE proposed to work with the Department of Energy to utilize and extend existing industry recognized Certified Energy Auditor (CEA) and Certified Building Commissioning Professional (CBCP) programs under this Training Program Development Announcement. These expanded training programs will have significant impact in training professionals for building commissioning and energy auditing to achieve the goal of bringing existing buildings up to their optimal energy performance potential and ensuring that new buildings maintain their expected optimal level of performance. The goals and objectives of the training development project were achieved with the development of new training programs that are now being offered as self-sustaining commercial training and certification programs. These new programs are training and certifying professionals who are accomplishing the goal of increasing building energy performance in both existing and new buildings.

  12. EURATOM-CEA association contributions to the 18. IAEA fusion energy conference

    Energy Technology Data Exchange (ETDEWEB)

    Ghendrih, Ph.; Peysson, Y.; Hoang, G.T. [and others

    2000-12-01

    The 9 contributions of EURATOM-Cea association to the fusion energy conference hold at Sorrento are gathered in this document with 7 additional papers. The different titles are: 1) Ergodic divertor experiments on the route to steady state operation of Tore-Supra, 2) High power lower hybrid current drive experiments in Tore-Supra tokamak, 3) Electron transport and improved confinement on Tore-Supra, 4) ECRH experiments and developments for long pulse in Tore-Supra, 5) Impurity penetration and contamination in Tore-Supra ergodic divertor experiments, 6) Real time plasma feed-back control: an overview of Tore-Supra achievements, 7) Numerical assessment of the ion turbulent thermal transport scaling laws, 8) Design of next step tokamak: consistent analysis of plasma flux consumption and poloidal, 9) Large superconducting conductors and joints for fusion magnets: from conceptual design to test at full size scale, 10) Burst-prone transport in tokamaks with internal transport barriers, 11) Electrostatic turbulence with finite parallel correlation length and radial electric field generation, 12) Theoretical issues in tokamak confinement: internal-edge transport barriers and runaway avalanche confinement, 13) Core and edge confinement studies with different heating methods in JET, 14) Confinement and transport studies of conventional scenarios in ASDEX upgrade, 15) First test results for the ITER central solenoid model coil, and 16) Progress of the ITER central solenoid model coil program.

  13. EURATOM-CEA association contributions to the 18. IAEA fusion energy conference

    International Nuclear Information System (INIS)

    The 9 contributions of EURATOM-Cea association to the fusion energy conference hold at Sorrento are gathered in this document with 7 additional papers. The different titles are: 1) Ergodic divertor experiments on the route to steady state operation of Tore-Supra, 2) High power lower hybrid current drive experiments in Tore-Supra tokamak, 3) Electron transport and improved confinement on Tore-Supra, 4) ECRH experiments and developments for long pulse in Tore-Supra, 5) Impurity penetration and contamination in Tore-Supra ergodic divertor experiments, 6) Real time plasma feed-back control: an overview of Tore-Supra achievements, 7) Numerical assessment of the ion turbulent thermal transport scaling laws, 8) Design of next step tokamak: consistent analysis of plasma flux consumption and poloidal, 9) Large superconducting conductors and joints for fusion magnets: from conceptual design to test at full size scale, 10) Burst-prone transport in tokamaks with internal transport barriers, 11) Electrostatic turbulence with finite parallel correlation length and radial electric field generation, 12) Theoretical issues in tokamak confinement: internal-edge transport barriers and runaway avalanche confinement, 13) Core and edge confinement studies with different heating methods in JET, 14) Confinement and transport studies of conventional scenarios in ASDEX upgrade, 15) First test results for the ITER central solenoid model coil, and 16) Progress of the ITER central solenoid model coil program

  14. METABOLISMO ÁCIDO DE LAS CRASULÁCEAS Crassulacean Acid Metabolism

    Directory of Open Access Journals (Sweden)

    THOMAS DAVID GEYDAN

    Full Text Available Se presenta una revisión del metabolismo ácido de las Crasuláceas, caracterizado por la ocurrencia, actividad y plasticidad del mecanismo desde un punto de vista fisiológico, bioquímico y molecular, enmarcado por la presencia de las denominadas cuatro fases de dicho metabolismo y su repercusión y expresión por diversas restricciones hídricas a nivel ecológico. Se presentan las principales enzimas y metabolitos básicos para el funcionamiento del metabolismo CAM, así como su modo de acción y control celular. Finalmente, se muestra que la plasticidad fenotípica en patrones de expresión CAM se encuentra mediada por condiciones ambientales y por señalizaciones moleculares.A review of Crassulacean acid metabolism is presented, characterized by showing the occurrence, activity and plasticity of these complex mechanism at the physiological, biochemical and molecular level, framed by the presence of the denominated four phases in CAM and its repercussion and expression due to different stresses in an ecological context. The basic enzymes, and metabolites necessary for the optional functioning of CAM are presented as well as their mode of action and cellular control. Finally, it is shown how environmental conditions and molecular signalling mediate the phenotypic plasticity.

  15. The 400W at 1.8K Test Facility at CEA-Grenoble

    Science.gov (United States)

    Roussel, P.; Girard, A.; Jager, B.; Rousset, B.; Bonnay, P.; Millet, F.; Gully, P.

    2006-04-01

    A new test facility with a cooling capacity respectively of 400W at 1.8K or 800W at 4.5K, is now under nominal operation in SBT (Low Temperature Department) at CEA Grenoble. It has been recently used for thermohydraulic studies of two phase superfluid helium in autumn 2004. In the near future, this test bench will allow: - to test industrial components at 1.8K (magnets, cavities of accelerators) - to continue the present studies on thermohydraulics of two phase superfluid helium - to develop and simulate new cooling loops for ITER Cryogenics, and other applications such as high Reynolds number flows This new facility consists of a cold box connected to a warm compressor station (one subatmospheric oil ring pump in series with two screw compressors). The cold box, designed by AIR LIQUIDE, comprises two centrifugal cold compressors, a cold turbine, a wet piston expander, counter flow heat exchangers and two phase separators at 4.5K and 1.8K. The new facility uses a Programmable Logic Controller (PLC) connected to a bus for the measurements. The design is modular and will allow the use of saturated fluid flow (two phase flow at 1.8K or 4.5K) or single phase fluid forced flow. Experimental results and cooling capacity in different operation modes are detailed.

  16. CEA and AREVA HTR fuel particles manufacturing and characterization R and D Program

    International Nuclear Information System (INIS)

    Worldwide, renewal of interest for High Temperature Reactors (HTR) moderated by graphite, using helium gas as coolant is due to the possibility offered by HTR technology to build small competitive modular units (100-300 MWe) and to produce high temperature gas required for hydrogen production or heat production. In this context, Commissariat a l'Energie Atomique (CEA) supported by AREVA, conducts R and D projects on HTR, which one is the mastering of the UO2 TRISO fuel fabrication technology including innovating prospects. The first step of the work is to recover fabrication know-how and to improve fabrication processes (for preparing the erection of a fuel pilot manufacture line of HTR particles). The second step will be the manufacturing of HTR fuel elements in purpose of irradiation tests. This publication deals with the know-how recovery and improved processes of UO2 TRISO manufacture, i.e. kernel and coatings manufacturing, the development of innovative characterization methods, a modelling approach of CVD processes and the status of the future laboratory manufacture line. Alternative fuel designs are also investigated, for instance the way of manufacturing UCO and UCx kernels with higher refractory coating material such as ZrC. (authors)

  17. Report on transparency and nuclear safety - INB unexploited by the Marcoule CEA - 2012

    International Nuclear Information System (INIS)

    This report presents the different nuclear base installations (INB) of the Marcoule CEA centre, gives an overview of measures regarding safety within these installations (organisation, general arrangements, arrangements related to different risks, management of emergency situations, inspections, audits and second-level controls, arrangements and main events specific to the different installations and buildings) and of measures related to radiation protection (organisation and results, main events). It reports the significant events related to safety and radiation protection which occurred in 2012 and were declared to the ASN, and discusses how the return-on-experience has been used. It reports and comments the results of measurements of gaseous and liquid effluents, of their impact on the environment, and of surveys of the environment. It also presents the environmental management approach. The next part addresses the management of radioactive wastes which are warehoused on this site: arrangements aimed at limiting their volume, and at limiting their impact on health and on the environment, nature and quantities of warehoused wastes. Remarks and recommendations of the CHSCT are given

  18. Apprasial of the diagnostic value of combined detection of serum tumor markers (AFP, CEA, SF, TSA) for common malignancies

    International Nuclear Information System (INIS)

    Objective: To assess the detection rate of common malignancies with combined determination of four serum tumor markers (AFP, CEA, SF, TSA). Methods: Serum AFP, CEA, SF (with RIA) and TSA (with biochemical method) contents were determined in 612 patients with various kinds of proved malignancies. Results: Positive rates of combined determination of these four tumor markers for detection of common malignancies were: 95.2%(79/83) for liver carcinoma, 92.6% (125/135) for lung carcinoma, 88.5% (115/130) for gastric cancer, 83.3% (60/72) for colorectal cancer, 84.2% (85/101) for breast cancer, 90.0% (9/10) for chorionepithelioma and 88.9% (72/81) for ovarian cancer. Conclusion: Combined determination of these four tumor markers for screening malignancies is simple, cheap, practical and worth popularization. (authors)

  19. Estrutura da vegetação herbácea em paisagens ciliares no sul de Santa Catarina, Brasil

    OpenAIRE

    Aline Votri Guislon; Karoline Ceron; Guilherme Alves Elias; Robson Santos; Vanilde Citadini-Zanette

    2016-01-01

    As características estruturais e ecológicas da vegetação herbácea fazem com que ela seja sensível às alterações do ambiente, atuando como indicador da qualidade ambiental. No entanto, o estudo dessa comunidade ainda é incipiente em regiões neotropicais. Este estudo descreve a florística e os aspectos fitossociológicos da vegetação herbácea terrícola na mata ciliar de sete rios, no município de Urussanga, sul do estado de Santa Catarina, além de analisar e quantificar o status do conhecimento ...

  20. Larva migrans within scalp sebaceous gland Larva migrans em glândula sebácea do couro cabeludo

    Directory of Open Access Journals (Sweden)

    Lucinda Calheiros Guimarães

    1999-04-01

    Full Text Available A case of larva migrans or serpiginous linear dermatitis on the scalp of a teenager is reported. An ancylostomid larva was found within a sebaceous gland acinus. The unusual skin site for larva migrans as well as the penetration through the sebaceous gland are highlighted. The probable mechanism by which the parasite reached the skin adnexa is discussed.Relata-se caso de larva migrans ou dermatite linear serpiginosa no couro cabeludo de adolescente, no qual o ancilostomídeo foi encontrado no interior de glândula sebácea. Destaca-se a possibilidade do helminto sediar-se em locais pouco usuais, das glândulas sebáceas serem via de penetração de larvas na pele e discute-se o provável mecanismo pelo qual o agente implantou-se no anexo cutâneo.

  1. Analysis of the radiochemical purity of DTPA-coupled anti-CEA monoclonal antibody labelled with samarium-153

    International Nuclear Information System (INIS)

    Objective: To establish a paper chromatography method for analyzing radiochemical purity of cyclic DTPA anhydride coupled anti-CEA monoclonal antibody (McAb) labelled with 153Sm. Methods: The separation efficacy of free 153Sm3+ and 153Sm-CEA McAb was determined with a variety of paper chromatograph systems. The optimal separation conditions were studied, and the result determined with this paper chromatography compared with that of Sephadex G-50 chromatograph. Results: The optimal separation condition of the paper chromatograph system was as follows: Tributyl phosphate: 2-butanone: ethyl acetate (V/V/V = 4/10/3) as solvent and No. 1 Xinhua filter paper immerged with 30% ammonium nitrate for 30 min. and then dried as carrier. The percentage of labelling field determined with this paper chromatography was consistent with that of Sephadex G-50 chromatograph. Conclusion: It is showed this method proves to be simple, convenient and can be rapidly performed

  2. Estimation of Public Health consequences of Tchernobyl nuclear accident (26 April 1986) based on CEA centers measurements

    International Nuclear Information System (INIS)

    Based on fallout measurements, additional radiation doses to the French population from external exposure to the plume, inhaled radioactivity and consumption of milk, meat and vegetables, have been estimated for the first period following the Chernobyl accident, by the various CEA centers in different regions of the country. Effective dose equivalent from the various exposures and radiation measurements in the different centers are presented in tables

  3. Tumour-associated trypsin inhibitor (TATI) in human ovarian cyst fluid. Comparison with CA 125 and CEA.

    OpenAIRE

    Halila, H.; Huhtala, M. L.; Haglund, C.; Nordling, S.; Stenman, U. H.

    1987-01-01

    The levels of tumour-associated trypsin inhibitor (TATI), CA 125 and CEA were measured in ovarian cyst fluids from 21 patients. TATI in cyst fluid was immunologically and physicochemically similar to the peptide originally isolated from the urine of a patient with ovarian cancer. Mucinous cysts contained significantly higher levels of TATI than did serous cysts. Immunohistochemically TATI was localized in the apical parts of cells of mucinous ovarian cysts. These results suggest that this tum...

  4. Direct compatibility check of the CEA and Cornell electroproduction pion form factor data with e+e- ones

    International Nuclear Information System (INIS)

    Using precise experimental information on the imaginary part of the pion form factor from e+e- → π+π- up to the inelastic threshold and QCD constraints for it in the range of momenta (mπ0+mω)2 < t < infinity, was investigated by means of a dispersion integral the reliability of individual electroproduction CEA and Cornell model-dependent pion form factor data points

  5. A Case of Radiation Fibrosis Appearing as Mass-Like Consolidation after SBRT with Elevation of Serum CEA

    Directory of Open Access Journals (Sweden)

    Kotaro Terashima

    2010-01-01

    Full Text Available We report a case of radiation fibrosis appearing as mass-like consolidation, which was difficult to distinguish from local recurrence. A 72-year-old woman was diagnosed as having primary lung cancer (cT1N0M0 stage IA in the right upper lobe and was treated with SBRT of 48 Gy in 4 fractions. After 12 months, mass-like consolidation appeared around the irradiated area, and after 13 months, it had increased in size. FDG-PET revealed high uptake (SUV max=5.61 for the consolidation. CT-guided biopsy was performed, but we could not confirm the diagnosis. Considering her poor respiratory function and her age, short-interval follow-up was performed. After 15 months, the consolidation enlarged at the dorsal side, and carcinoembryonic antigen (CEA became elevated (14.6 ng/mL. Serum KL-6 (436 U/mL and SP-D (204 ng/mL were also elevated. However, after 16 months, serum CEA slightly decreased. The consolidation gradually retracted on follow-up CT images. CEA, KL-6, and SP-D were also decreased by degrees. After 40 months, there is no evidence of local recurrence.

  6. Multimodality treatment of primary nonresectable intrahepatic cholangiocarcinoma with I-131 anti-CEA: A radiation therapy oncology group study

    International Nuclear Information System (INIS)

    Thirty-seven patients (57% with metastasis and/or who has previously undergone chemotherapy) with primary unresectable intrahepatic cholangiocarcinoma were prospectively treated with external beam radiation therapy, chemotherapy, and I-131 anti-carcinoembryonic antigen (CEA) antibody. The regimen led to partial remission in 26.6% of patients, according to CT scan digitized tumor volume analysis, and in 33.3% (25.9% with partial remission, 7.4% with complete emission) according to physical examination findings. Therapy began with whole liver irradiation (2.1 Gy, 0.3 Gy per fraction, delivered 4 days a week, with 10-MV photons) and, on alternate days, chemotherapy (Adriamycin, 15 mg, + 5-fluorouracil [5-FU], 500 mg). One month later, Adriamycin, 15 mg, + 5-FU, 500 mg, was administered on day 0; 20 mCi of I-131 anti-CEA on day 1; and 10 mCi of I-131 anti-CEA on day 6. Tumor effective half-life was 3-5 days. Median tumor dose (20 mCi + 10 mCi) was 6.2 Gy. Antibody therapy was administered in 2-month cycles. Grade IV thrombocytopenia and leukopenia each occurred in 3.2% of patient administrations. Median survival for the entire group was 6.5 months; for responders, it was 15.2 months. The longest partial remission is presently more than 4 years

  7. Rosácea granulomatosa: relato de caso - enfoque terapêutico Granulomatous rosacea: case report - a therapeutic focus

    Directory of Open Access Journals (Sweden)

    Pedro Bezerra da Trindade Neto

    2006-10-01

    Full Text Available Os autores descrevem um caso de rosácea granulomatosa em um homem de 39 anos de idade, tratado com a associação de limeciclina oral e metronidazol gel tópico. A rosácea granulomatosa é uma variante da rosácea clássica, rara, caracterizada pela presença de pápulas vermelho-acastanhadas ou pequenos nódulos com base eritematosa e infiltrada, surgindo geralmente na superfície lateral da face e no pescoço. O exame histopatológico evidencia granulomas perifoliculares e perivasculares. A evolução é crônica, e o tratamento inclui antibióticos orais, como a tetraciclina e seus derivados, e medicações tópicas, como metronidazol, ácido retinóico, entre outras.The authors describe a case of granolumatous rosacea in a 39-year-old male, successfully treated with oral limecycline and topical gel of metronidazole. Granulomatous rosacea is a rare form of classic rosacea, characterized by brownish-red papules or small nodules on a diffusely reddened background and thickened skin. Lesions generally appear on the lateral surfaces of the face and on the neck. Histopathological examination shows perifollicular and perivascular granulomas. The course is chronic and treatment involves oral antibiotics, such as tetracycline and derivates; and topicals, such as metronidazole and topical retinoids.

  8. TIMP-1 and CEA as biomarkers in third-line treatment with irinotecan and cetuximab for metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Spindler, Karen-Lise Garm; Christensen, Ib Jarle; Nielsen, Hans Jørgen; Jakobsen, Anders; Brünner, Nils

    2015-01-01

    colorectal cancer (CRC). The aim of the present study was to investigate the clinical value of TIMP-1 in patients with metastatic colorectal cancer (mCRC) treated with cetuximab and irinotecan. Patients with chemotherapy-resistant mCRC referred to third-line treatment with cetuximab (initial 400 mg/m(2......) followed by weekly 250 mg/m(2))/irinotecan (350 mg/m(2) q3w) were prospectively included in the biomarker study, as previously published. Pre-treatment blood samples were collected, and plasma TIMP-1 was measured by a validated in-house ELISA assay. In addition, carcinoembryonic antigen (CEA) measurement...... tumour localisation) or to differences in PFS or OS. The rank correlation between CEA and TIMP-1 was r = 0.50, and a test for interaction between TIMP-1 and CEA (dichotomised at 5 ng/ml) in survival analysis was not significant (p = 0.18). A multivariate analysis for PFS and OS resulted in a model with...

  9. Calagem, adubação e nutrição mineral de Anonáceas

    Directory of Open Access Journals (Sweden)

    Danilo Eduardo Rozane

    2014-01-01

    Full Text Available Entre os fatores edáficos, os ligados à acidez são os que mais interferem na produtividade, especialmente nas regiões tropicais. Para a cultura das anonáceas, não há resultados de pesquisa que indiquem a adequada saturação por bases, nem tão pouco a determinação de doses, épocas, modos de aplicação e fontes de nutrientes para pomares de anonáceas em formação e produção, a fim de promover sustentabilidade e elevadas produtividades. Tendo em vista a importância e o potencial de exploração comercial das anonáceas no Brasil e, considerando-se a escassa informação científica disponível sobre calagem, adubação e nutrição dessa família de plantas frutíferas, algumas pesquisas têm urgência de serem realizadas em função dos efeitos dos nutrientes sobre a produtividade, a qualidade dos frutos, a pós-colheita, a tolerância a pragas e doenças e, etc.

  10. Diagnostic value of combined measurement of serum CEA, AFP, CA19-9 and SA levels in patients with primary hepatic cancer

    International Nuclear Information System (INIS)

    Objective: To study the diagnostic value of combined measurement of serum CEA, AFP, CA19-9 and SA levels for primary hepatic cancer. Methods: Serum CEA, AFP, CA19-9 (with RIA) SA (with biochemistry) levels were measured in 36 patients with primary hepatic cancer and 35 controls. Results: As a single tumor marker for diagnosis, the sensitivity of CEA, AFP, CA19-9, SA was 33.3%, 69.4%, 58.5% and 61.1% respectively, the specificity was 60.4%, 81.3% 68.8%, 64.4% respectively. With combined detection of the four markers and assuming two or more markers positive as positive, the sensitivity would be 94.4% and specificity would be 95.8%. Conclusion: Combined measurement of serum CEA, AFP, CA19-9 and SA levels is of clinical usefulness for diagnosis of primary hepatic cancer. (authors)

  11. High Plasma TIMP-1 and Serum CEA Levels during Combination Chemotherapy for Metastatic Colorectal Cancer Are Significantly Associated with Poor Outcome

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Byström, Per; Berglund, Ake; Christensen, Ib J; Brünner, Nils; Nielsen, Hans Jørgen; Glimelius, Bengt

    overall survival. Materials and Methods: Eighty-eight patients with mCRC were included. Blood samples were collected before initiation and after 2, 4 and 6 weeks of treatment with an irinotecan-5-fluorouracil combination. Plasma TIMP-1 and serum CEA levels were determined by validated ELISA platforms. The...... associated with poor overall survival; p <0.0001 in all 4 determinations. A similar association between serum CEA and overall survival could only be demonstrated before treatment. Conclusion: Median plasma TIMP-1 or serum CEA levels do not change significantly during the first 6 weeks of chemotherapy for m......Objective: To evaluate whether combination chemotherapy leads to early changes in plasma TIMP-1 and serum carcinoembryonic antigen (CEA) levels in patients with metastatic colorectal cancer (mCRC), and whether such changes relate to subsequent objective response, time to progression (TTP) and...

  12. The use of tumour markers CEA, CA-195 and CA-242 in evaluating the response to chemotherapy in patients with advanced colorectal cancer.

    OpenAIRE

    Ward, U.; Primrose, J N; Finan, P. J.; Perren, T. J.; Selby, P.; Purves, D. A.; Cooper, E H

    1993-01-01

    Tumour markers CEA, CA-195 and CA-242 were measured in 33 patients undergoing chemotherapy for advanced colorectal cancer. The aim was to determine whether they could be used to accurately monitor the course of the disease, and reduce the need for imaging. Treatment with a 5-fluorouracil based regimen resulted in a partial response in nine patients (27%), whereas the remainder either had disease stabilisation or suffered from progression. Before treatment the CEA was elevated in 85% of patien...

  13. Combined detection of preoperative serum CEA, CA19-9 and CA242 improve prognostic prediction of surgically treated colorectal cancer patients

    OpenAIRE

    Wang, Jingtao; Xiao WANG; Yu, Fudong; Chen, Jian; Zhao, Senlin; Zhang, Dongyuan; YU, Yang; Liu, Xisheng; Tang, Huamei; Peng, Zhihai

    2015-01-01

    We assessed the prognostic significance of preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 242 (CA242) levels in surgically treated colorectal cancer patients. The relationship of preoperative serum CEA, CA19-9 and CA242 levels with disease characteristics was investigated in 310 patients. Correlation between tumor markers was investigated using Pearson correlation test. Univariate and multivariate survival analyses were used to s...

  14. Estrutura da vegetação herbácea em paisagens ciliares no sul de Santa Catarina, Brasil

    Directory of Open Access Journals (Sweden)

    Aline Votri Guislon

    2016-06-01

    Full Text Available As características estruturais e ecológicas da vegetação herbácea fazem com que ela seja sensível às alterações do ambiente, atuando como indicador da qualidade ambiental. No entanto, o estudo dessa comunidade ainda é incipiente em regiões neotropicais. Este estudo descreve a florística e os aspectos fitossociológicos da vegetação herbácea terrícola na mata ciliar de sete rios, no município de Urussanga, sul do estado de Santa Catarina, além de analisar e quantificar o status do conhecimento científico relacionado às herbáceas terrícolas no Brasil. Foram levantadas 320 unidades amostrais de 4 m², nas quais todos os indivíduos foram identificados e dados relacionados aos parâmetros fitossociológicos foram coletados. A amostragem resultou em 58 táxons, 38 pertencentes às angiospermas e 20 às samambaias, distribuídos em 25 famílias botânicas. Poaceae apresentou maior riqueza, com 11 espécies. Estruturalmente, destacaram-se Goeppertia monophylla (Vell. Borchs. e S. Suárez, Blechnum brasiliense Desv. e Heliconia farinosa Raddi. A forma de vida mais frequente foi a hemicriptófita reptante. Os resultados revelam uma elevada riqueza de herbáceas terrícolas adaptadas às condições climáticas das matas ciliares, contribuindo para a diversidade da flora regional. Quanto à produção científica, foram encontrados 50 trabalhos indexados nas bases de dados eletrônicas (1990 a 2015, com destaque ao ano de 2011, que teve maior produção científica enfocando as herbáceas terrícolas. Embora com baixo número, a quantidade de indexações tende a crescer, em virtude do avanço da tecnologia de acesso às bases de dados e pela crescente adesão de periódicos em portais de busca.

  15. Produção integrada de Anonáceas no Brasil

    Directory of Open Access Journals (Sweden)

    Raimundo Braga Sobrinho

    2014-01-01

    Full Text Available Os conceitos técnicos e operacionais contidos na Produção Integrada (PI vêm atender de forma direta às exigências dos órgãos nacionais e internacionais que fiscalizam o comércio de "commodities", dando ênfase à segurança e a qualidade dos alimentos produzidos e consumidos pela população. A garantia da produção de um alimento seguro e rastreável é alcançada mediante o esforço harmônico de todos os integrantes da cadeia produtiva. Esse sistema pressupõe o cumprimento das Normas Técnicas Específicas (NTE para cada produto, permitindo o controle efetivo do sistema produtivo agropecuário por meio do monitoramento de todas as etapas na cadeia produtiva. Esse conceito teve início com o Manejo Integrado de Pragas (MIP e, posteriormente, expandiu-se para uma visão holística, estruturada em quatro pilares de sustentação: organização da base produtiva; sustentabilidade do sistema; monitoramento dos processos; e formação de um banco de dados. Dentro desta visão, insere-se a Produção Integrada de Anonáceas, projeto iniciado em 2010, com apoio do CNPq/MAPA/EMBRAPA e instituições parceiras. As anonáceas representam um nome genérico para designar as plantas da família Annonaceae constituída por cerca de 120 gêneros e em torno de 2.300 espécies. No Brasil, estão registrados 29 gêneros, dentro dos quais cerca de 260 espécies. Entre as espécies de maior importância comercial, destacam-se a graviola (Annona muricata L., pinha (Annona squamosa L., cherimólia (Annona cherimólia, Mill. e a atemoia, hibrido de A. cherimólia e A. squamosa. Essas frutas têm alta aceitação pelo seu sabor e possibilidade de uso para consumo in natura, sucos e geleias. As áreas comercialmente cultivadas são concentradas nos Estados do Nordeste do Brasil. Os Estados de maior concentração: Bahia para graviola e pinha, Alagoas para pinha e São Paulo para atemoia. Os resultados de pesquisa envolvendo toda a cadeia produtiva dessas

  16. Annual report of the Association EURATOM-Cea 2003 (full report)

    International Nuclear Information System (INIS)

    This annual report summarizes activities performed by the EURATOM-Cea association in 2003 but only those concerning plasma-facing components are detailed. A full scale prototype mock-up of the ITER divertor vertical target has been high heat flux tested. The reference solution CFC mono-blocks made of SEP NB31 tiles and CrCrZr tubes confirmed a good behaviour under fatigue testing. Studies on high flux tested primary first wall panels have showed that cracks can be directly related to a problem of manufacturing or welding. The applicability of the hot isostatic pressing (HIP) technologies for manufacturing primary first wall is being investigated through the fabrication and testing of mock-ups. Samples of nano-structured SiC have been obtained by HIP of green-compacts made up of nano-powders synthesized by laser pyrolysis. Another task has been to assess the risk of failure in cascade of flat tiles under convective heat flux. The expected phenomenon of cascade failure did not occur during the tests. Tests concerning the erosion of graphite tiles have been performed. Chamfering angles for the new tiles of the MKII-HD divertor have been optimized to insure a good shadowing of the edges for the 12 reference plasma configurations. Pre-tests of 3-dimensional calculations of JET divertor tiles have been performed. The detritiation of plasma-facing components through the use of a laser beam has been investigated. Thick tungsten coating by chemical vapor deposition had been studied for copper divertor component. (A.C.)

  17. Experience acquired by the Mobile Remote-Control Operation and Detection Group of the CEA

    International Nuclear Information System (INIS)

    In recent years the Mobile Remote-Control Operation and Detection Group of the CEA have intervened on various occasions as follows: to replace personnel required to spend time in working areas in which dose rates were permanently high or very high; to support personnel required to work near high-activity sources producing or likely to produce mobile or short-lived beams of ionizing radiation; and to support personnel required to perform tedious and/or repetitive operations in working areas in which only a limited amount of time may be spent. Among the interventions performed, mention is made of the recovery of radioactive sources which have been placed in abnormal positions as a result of incorrect handling or incidents involving machinery; the transfer of radioactive sources during the loading or unloading of irradiation devices; the inspection by television camera, modification, dismantling or reassembly of protective devices in the neighbourhood of high- or very high-activity sources; and the cleaning of installations polluted by radioactive contaminants which present a high risk of external irradiation of the personnel required to work there. After obtaining a hermetically sealed version of the ''Mobile Remote-Control Intervention Operator'' (TOMI) and an ''Intervention Dose and Dose-Rate Measurement Unit'' (EDDI) in 1979, the Mobile Remote-Control Operation and Detection Group has very recently put into operation a remote-controlled intervention module which takes up very little space and can carry over 100 kg of different types of equipment. The authors summarize development work on the MERITE module and on master-slave remote handling devices with servo control and feedback of the MA-23 type, the flexibility of which has yet again been verified very recently during an intervention at a nuclear installation. (author)

  18. Recent Improvements at CEA on Trace Analysis of Actinides in Environmental Samples

    International Nuclear Information System (INIS)

    In this paper, we present some results of R and D works conducted at CEA to improve on the one side the performance of the techniques already in use for detection of undeclared activities, and on the other side to develop new capabilities, either as alternative to the existing techniques or new methods that bring new information, complementary to the isotopic composition. For the trace analysis of plutonium in swipe samples by ICP-MS, we demonstrate that a thorough knowledge of the background in the actinide mass range is highly desirable. In order to avoid false plutonium detection in the femtogram range, correction from polyatomic interferences including mercury, lead or iridium atoms are in some case necessary. Efforts must be put on improving the purification procedure. Micro-Raman spectrometry allows determining the chemical composition of uranium compound at the scale of the microscopic object using a pre-location of the particles thanks to SEM and a relocation of these particles thanks to mathematical calculations. However, particles below 5 μm are hardly relocated and a coupling device between the SEM and the micro-Raman spectrometer for direct Raman analysis after location of a particle of interest is currently under testing. Lastly, laser ablation - ICP-MS is an interesting technique for direct isotopic or elemental analysis of various solid samples and proves to be a suitable alternative technique for particle analysis, although precision over isotopic ratio measurement is strongly limited by the short duration and irregularity of the signals. However, sensitivity and sample throughput are high and more developments are in progress to validate and improve this method. (author)

  19. LWR Fuel Gas Characterization at CEA Cadarache LECA-STAR Hot Laboratory

    International Nuclear Information System (INIS)

    The aim to improve LWR fuel behaviour led CEA to improve its PIE capacities in term of test devices and characterization techniques in the shielded hot cells of the LECA-STAR facility, located in Cadarache. A presentation of these capacities is made, focusing on gas characterization : - annealing test devices used for transient simulations. These devices are test facilities allowing to simulate a very large range of conditions (temperature, atmosphere, pressure etc); - characterization techniques : optical microscopy, for microstructure characterizations on polished samples; scanning electron microscopy (SEM) used both on polished samples and on fractographs; Electron Probe Micro-Analyzer (EPMA) for quantitative elementary analysis and elementary mappings; Secondary Ion Mass Spectrometer (SIMS), for isotopic analysis, mapping depth profiles and gas measurements. It shows an overview of their main applications for the study of fuel behaviour under nominal operating conditions but also under simulated accidental conditions and storage conditions. Two detailed examples of the use of these techniques working together on the same samples, are then presented, focusing on fission gas characterizations. The first one is a 72 GW.d.t-1 high burnup UO2 PWR fuel for which detailed characterizations have been performed before and after a LOCA type condition annealing test. The second one is a 35 GW.d.t-1 UO2 PWR fuel for which these characterizations have been done before and after a ramp test at 100 W.cm-1.min-1 up to a 90 s maximum power hold time at 520 W.cm-1. In both cases, the complementarities of these various techniques show the interest of such detailed characterizations. (author)

  20. Seismological studies carried out by the CEA in connection with the safety of nuclear sites

    International Nuclear Information System (INIS)

    In order to evaluate the seismic risk at nuclear sites, the Department of Nuclear Safety of the French Atomic Energy Commission (CEA) has been conducting a programme of seismological studies for several years past. This programme is aimed at acquiring a better knowledge of seismic phenomena, in particular the spectral distribution of the energy of earthquakes, considered to be the only correct approach to the problem of earthquake protection, as well as a better knowledge of the seismic activity of the areas surrounding nuclear sites. The authors propose defining the design spectrum of the site on the basis of the probable energy at the source, the distance from the epicentre and the transfer function of the geological formations. The need - for the purpose of defining this spectrum - to acquire data on the characteristics of French earthquakes and on regional seismicity led the Department of Nuclear Safety to set up a network of seismic stations. It now has an observatory at the Cadarache Nuclear Research Centre and mobile stations with automatic magnetic recording for studying aftershock sequences and the activity of faults in the vicinity of nuclear sites, and for making the measurements necessary to calculate the transfer functions. With this equipment it was possible to record six aftershocks of the Oleron earthquake on 7 September 1972 close to the epicentre, and to calculate the spectra therefrom. The latter contained a lot of high frequencies, which is in agreement with the data obtained from other sources for earthquakes of low energy. The synthetic spectra calculated on the basis of one magnitude and one distance are in good agreement with the spectra obtained experimentally

  1. Current status of thermohydraulic validation studies at CEA-Grenoble for the SIMMER-III code

    International Nuclear Information System (INIS)

    SIMMER-III (SIII) is a two-dimensional, three-velocity-field, multiphase, multicomponent, Eulerian, fluid-dynamics code coupled with a space- and energy-dependent neutron kinetics model, to investigate postulated core disruptive accidents in LMFRs. It is developed by PNC, Japan. The paper makes the synthesis of the SIII assessment performed at CEA-Grenoble since 1996, which covers a large variety of multiphase flows, from two-phase flow basic modelling to LMFR accident simulation experiments with real materials. Single bubbles or droplets equilibrium radii and velocities, air/water experiments in tubes, and comparisons with the literature, are used to qualify the interfacial area convection equation and the momentum exchange functions. Using the second order differencing scheme of the Navier-Stokes equation, a turbulence model for two-phase recirculating flows is implemented. It is successfully validated on an adiabatic air/water experiment, and on the Sebulon boiling pool simulation experiment, which is a box of water internally heated, with a cover gas, and cooled at the walls. The successful calculations of the SGI experiment and of a reactor scale case contribute to the code validation for LMFR expansion phase. Besides, the large scale UO2/sodium interactions of the Termos T1 experiment, and the UO2 boiling pool laterally cooled with sodium flow at the wall of the Scarabee BF2 experiment, is also studied with SIM Lastly, satisfying results are obtained with the calculation of the Scarabee APL3 slow pump run down without scram. It is shown that SIII is a state-of-the-art tool to simulate transient multiphase phenomena. The paper also discusses those areas, identified through these assessment calculations, which require further research and development. (author)

  2. Actinides exposure: review of Ca-DTPA injections inside Cea-Cogema plants; Exposition aux actinides: bilan des injections de Ca-DTPA dans les centres CEA-Cogema

    Energy Technology Data Exchange (ETDEWEB)

    Grappin, L.; Berard, P.; Beau, P.; Carbone, L.; Castagnet, X.; Courtay, C.; Le Goff, J.P.; Menetrier, F.; Neron, M.; Piechowski, J. [CEA Cadarache, Dir. de l' Energie Nucleaire, Dept. de Soutien en surete et securite, Sev. de Sante au Travail, 13 - Saint-Paul-lez-Durance (France)

    2006-07-01

    Ca-DTPA has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This report is a survey of the injections administered of Ca-DTPA as a chelating molecule. This report will be a part of the AMM process for Ca-DTPA by intravenous administration submitted by the Central Pharmacy of the french Army. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contaminations were reported. These employees were followed by occupational physicians according to the current regulations. The first part of the report is a synthesis of the most recent findings. Due to its short biological period and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary. The second part presents data concerning these 1158 injections (way of contamination, posology, adverse effects...). These incidents took place at work, were most often minor, not requiring follow-up treatment. A study concerning the effectiveness of the product was done on a group of people having received 5 or more injections. These results were compared with effectiveness estimated from theoretical basis. Posologies and therapeutic schemes were proposed based on these observations. Additional studies are needed to confirm these findings. This document is the first synthesis in this field. It is the result of a collective work having mobilized the occupational medicine departments, the laboratories of CEA and COGEMA and a working group CEA-COGEMA-SPRA. (authors)

  3. Evaluation of the radiology state at the CEA/Fontenay-aux-Roses and its environment; Point sur l'etat radiologique du CEA/Fontenay-aux-Roses et de son environnement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    Since 1946 the nuclear installations followed one other at the CEA of Fontenay-aux-Roses still their gradual stop the last ten years, except two installations INB34 and INB73, necessary for the wastes management. Today these installations form the subject of a drainage program. The public opinion is regularly informed on this program since 1999. This document presents the stock of the actions realized since this date: the track keeping of the sites activities impacts on the environment and the actions realized since 1999. (A.L.B.)

  4. Porous platinum nanoparticles and PdPt nanocages for use in an ultrasensitive immunoelectrode for the simultaneous determination of the tumor markers CEA and AFP

    International Nuclear Information System (INIS)

    We describe the use of porous platinum nanoparticles (pPt NPs) and PdPt nanocages (PdPt NCs) in an electrochemical immunoassay for two tumor markers (CEA and AFP) directly in serum and with enhanced detection performance. The pPt NPs possess a high specific surface area and electrical conductivity, while the PdPt NCs display excellent catalytic property and high loading capacity. The PdPt NCs were labeled with anti-CEA and thionine, and the PdPt NCs were labeled with anti-AFP and ferrocene. The resulting electrode displayed a large decrease of the anodic peak current and an increase of cathodic peak current for hydrogen peroxide (H2O2). The dual square wave voltammetric immunoassay was performed at −0.1 V (for CEA) and +0.6 V (for AFP) after exposure to a sample containing CEA and AFP and in the presence of H2O2. CEA can be detected in the 0.05 to 200 ng mL−1 concentration range and AFP between 0.03 and 100 ng mL−1. The limits of detection are 1.4 pg mL−1 for CEA and 1 pg mL−1 for AFP (at an SNR of 3). The sensitivity of the method (expressed as slope vs. concentration) is better by a factor of 4.6 to 100 compared to conventional electrochemical immunoassays. Analytical data obtained with diluted serum samples were in good agreement with reference values obtained via a standard ELISA. Negligible cross-reactivity is found between CEA and AFP. In our opinion, this approach paves the way for developing other kinds of electrochemical immunosensors based on the use of pPt NPs and PdPt NCs as materials for designing new electrode interfaces. (author)

  5. Super-Phenix benchmark used for comparison of PNC and CEA calculation methods, and of JENDL-3.2 and CARNAVAL IV nuclear data

    International Nuclear Information System (INIS)

    The study was carried out within the framework of the PNC-CEA collaboration agreement. Data were provided, by CEA, for an experimental loading of a start-up core in Super-Phenix. This data was used at PNC to produce core flux snapshot calculations. CEA undertook a comparison of the PNC results with the equivalent calculations carried out by CEA, and also with experimental measurements from SPX. The results revealed a systematic radial flux tilt between the calculations and the reactor measurements, with the PNC tilts only ∼30-40% of those from CEA. CEA carried out an analysis of the component causes of the radial tilt. It was concluded that a major cause of radial tilt differences between the PNC and CEA calculations lay in the nuclear datasets used: JENDL-3.2 and CARNAVAL IV. For the final stage of the study, PNC undertook a sensitivity analysis, to examine the detailed differences between the two sets of nuclear data. The sensitivity analysis showed that a relatively small number of nuclear data items contributed the bulk of the radial tilt difference between calculations with JENDL-3.2 and with CARNAVAL IV. A direct comparison between JENDL-3.2 and CARNAVAL IV data revealed the following. The Nu values showed little difference. The only large fission cross-section differences were at low energy. Although down-scattering reactions showed some large fractional differences, absolute differences were negligible compared with in-group scattering; for in-group scattering fractional differences were up to ∼75%, but generally <20%. There were many large differences in capture cross-sections, generally ∼30-200%. (J.P.N.)

  6. Relationship between peripheral and mesenteric serum levels of CEA and CA 242 with staging and histopathological variables in colorectal adenocarcinoma Níveis séricos periféricos e mesentéricos de CEA e CA 242, estadiamento e variáveis histopatológicas no adenocarcinoma colorretal

    Directory of Open Access Journals (Sweden)

    Mauro Lamelas Cardoso

    2009-10-01

    Full Text Available PURPOSE: To compare histopathological variables and staging in colorectal adenocarcinoma cases with CEA and CA 242 in peripheral and mesenteric blood. METHODS: In 169 individuals underwent surgery for colorectal cancer, CEA and CA 242 were analyzed and compared to mesenteric and peripheral blood and correlated with macroscopic tumor's morphology and size, degree of cell differentiation, venous, neural and lymphatic involvement and TNM classification. RESULTS: There was a difference between the mesenteric (M and peripheral (P serum levels of CEA (p=0.020. Higher levels of markers were correlated with venous invasion CEA (P p=0.013, CEA (M p=0.05, CA 242 (M p=0.005 and CA 242 (P p=0.038; with advanced staging CEA (P OBJETIVO: Comparar variáveis histopatológicas e graus de estadiamento do adenocarcinoma colorretal com níveis sanguíneos periféricos e mesentéricos de CEA e CA-242. MÉTODOS: Em 169 doentes submetidos ao tratamento cirúrgico por adenocarcinoma colorretal, CEA e CA-242 foram analisados e comparados quanto aos níveis sanguíneos periféricos e mesentéricos e correlacionados com o tamanho e a morfologia macroscópica do tumor, grau de diferenciação celular, invasões venosa, linfática, neural e a classificação TNM. RESULTADOS: Verificou-se diferença significante entre o nível sérico mesentérico e periférico de CEA (p= 0,02. Níveis séricos mais elevados dos marcadores foram observados e correlacionados com invasão venosa, CEA (P p=0,013, CEA(M, p=0,05, CA-242 (M p=0,005 e CA-242 (P p=0,038. Grau de estadiamento TNM avançado foi associado com CEA(P < CEA(M p<0,05, CA-242(P < CA-242(M p<0,05. Nas maiores dimensões tumorais constatou-se CEA(P < CEA(M p=0,001 e CA 242 (P < CA 242 (M (p < 0.001. O CA 242 periférico e mesentérico aumentados associaram-se com a invasão neural, p=0.014 e p=0.003, respectivamente. CONCLUSÕES: O nível sérico mesentérico de CEA é superior ao nível sérico periférico. Os níveis s

  7. Sobre la presencia de cactáceas naturalizadas en la costa meridional de Cataluña

    Directory of Open Access Journals (Sweden)

    Sanz-Elorza, Mario

    2004-06-01

    Full Text Available The authors report on the finding of eight new alien cacti naturalised in the Baix Camp (Tarragona. Three of these are new records for Europe, two are new records for Spain and one is a first record for Tarragona province. Two further species are not new floristic records however some revision of their status in Catalonia is required. Discussed is the extensive use of alien plant species in garden design in the area and the mildness of the local climatic conditions which has resulted in the greatest accumulation of naturalised cacti in Europe.En una riera de la comarca del Baix Camp (Tarragona hemos encontrado ocho especies de cactáceas alóctonas naturalizadas. De ellas, tres son nuevas para Europa, dos nuevas para España, una nueva para la provincia de Tarragona y, finalmente, otras dos sin ser novedad florística requieren aclaraciones en lo concerniente a su estatus en Cataluña. Este hallazgo representa la mayor biodiversidad de cactáceas citada hasta el momento para toda Cataluña, para toda la Península Ibérica e incluso para toda Europa. La introducción de especies exóticas en general y de cactáceas en particular se ve favorecida en esta comarca de la costa mediterránea por el desarrollo de una jardinería basada casi exclusivamente en elementos foráneos y en la existencia de una climatología muy favorable.

  8. Fractionated 131I anti-CEA radioimmunotherapy: effects on xenograft tumour growth and haematological toxicity in mice

    OpenAIRE

    Violet, J A; Dearling, J L J; Green, A. J.; Begent, R H J; Pedley, R B

    2008-01-01

    Dose fractionation has been proposed as a method to improve the therapeutic ratio of radioimmunotherapy (RIT). This study compared a single administration of 7.4 MBq 131I-anti-CEA antibody given on day 1 with the same total activity given as fractionated treatment: 3.7 MBq (days 1 and 3), 2.4 MBq (days 1, 3, and 5) or 1.8 MBq (days 1, 3, 5, and 8). Studies in nude mice, bearing the human colorectal xenograft LS174T, showed that increasing the fractionation significantly reduced the efficacy o...

  9. List of reports in the field of reactor safety research of BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning single problems in the field of Reactor Safety Research. According to the cooperation of the Bundesminister fuer Forschung und Technologie (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programm of the BMFT, reporting organization. The list of reports appears quarterly. (orig.)

  10. Sandia National Laboratories results for the 2010 criticality accident dosimetry exercise, at the CALIBAN reactor, CEA Valduc France.

    Energy Technology Data Exchange (ETDEWEB)

    Ward, Dann C.

    2011-09-01

    This document describes the personal nuclear accident dosimeter (PNAD) used by Sandia National Laboratories (SNL) and presents PNAD dosimetry results obtained during the Nuclear Accident Dosimeter Intercomparison Study held 20-23 September, 2010, at CEA Valduc, France. SNL PNADs were exposed in two separate irradiations from the CALIBAN reactor. Biases for reported neutron doses ranged from -15% to +0.4% with an average bias of -7.7%. PNADs were also exposed on the back side of phantoms to assess orientation effects.

  11. CA 242, a new tumour marker for pancreatic cancer: a comparison with CA 19-9, CA 50 and CEA.

    OpenAIRE

    Haglund, C.; Lundin, J; Kuusela, P.; Roberts, P. J.

    1994-01-01

    The serum expression of a novel tumour marker, CA 242, defined by monoclonal antibody C 242, was studied in 179 patients with pancreatic cancer. The results were compared with CA 19-9, CA 50 and CEA. CA 242 is a carbohydrate closely related, but not identical, to CA 19-9 and CA 50. The overall sensitivity of the CA 242 assay was 74%: 55% in stage I, 83% in stage II-III and 78% in stage IV disease. The specificity calculated from 112 patients with benign diseases was 91%. CA 19-9 had a higher ...

  12. Rapport d'étude : La perception des risques majeurs par les riverains du CEA de Cadarache

    OpenAIRE

    Lopez, Alexia; Régner, Isabelle; Schleyer-Lindenmann, Alexandra

    2015-01-01

    Ce rapport d'étude vient répondre aux interrogations de son commanditaire, la CLI (Commission Local d'Information) du CEA (Commissariat à l'énergie Atomique) de Cadarache. Il s'organise en trois partie : une première partie établit un état des lieux des connaissances des risques majeurs par les habitants. Les risques majeurs officiellement recensés sont : le risque feu de forêt, le risque inondation, le risque sismique, le risque de mouvement de terrain, le risque de rupture de barrage, et le...

  13. Development work on the SABRE code done by the CEA. Introduction of a new detailed wire-wrap model

    International Nuclear Information System (INIS)

    The versatility of the SABRE 2A code was extended by the CEA through the inclusion of a detailed treatment of the helical wire spacers, which is coherent with the sharp tridimensional analysis at the basis of the code development. This model was tested satisfactorily in comparison with experimental data from assemblies geometrically similar to CRBR and SPX1 fuel assemblies. The complex flow field inside the bundle seems well calculated, which enables to represent the mixing effects of the wire spacers at a macroscopic level

  14. Studies of monoclonal antibodies IOR-CEA-1 and IOR-EGF/R3 labelled with 99mTc

    International Nuclear Information System (INIS)

    Nuclear Medicine is a speciality that uses radioisotopes for the diagnosis or treatment of diseases and it is considered one of the best tools among the diagnostic modalities for detection of cancer. 99mTc is one of the main isotopes for labelling antibodies and in Nuclear Medicine in general, due to its adequate physical properties, availability and low cost. Labelled monoclonal antibodies have shown promising results for diagnosis and therapy of cancer and their use has brought great experimental and clinical advances in the field of oncology. The main clinical applications of immunoscintigraphy with monoclonal antibodies are staging and evaluation of tumoral reappearance. The antibodies employed in this work were: OIR-CEA-1, a murine monoclonal antibody that acts directly against CEA expressed in several neoplasia in particular those from the gastrointestinal tract (colorectal cancer) and IOR-EGF/R3, a murine monoclonal antibody that binds to the external domain of EGF-R and it has been used in the diagnosis of tumors of epithelial origin. The objectives of this work were the development and optimization of the reduction and purification processes, the radiolabelling techniques and quality control procedures (radiochemical, immunoreactivity and cystein challenge) and imaging studies of monoclonal antibodies OIR-CEA-1 and IOR-EGF/R3, using the simple, fast and efficient method of direct labelling of the antibody with 99mTc. The final results was the definition of the best conditions for the preparation of lyophilized reactive kits of OIR-CEA-1 and IOR- EGF/R3 for an efficient diagnostic application in Nuclear Medicine. The most adequate conditions for the labelling of the antibodies were: 1.0 mg Ab, 29 μL MDP, 3.0 μg Sn2+, 1 mL of 99mTc and 30 min. reaction time. With these conditions the labelling yield was always higher than 95% and the maximum activity of 99mTc was about 2220 MBq (60 mCi). The evidences of the efficiency and quality of the methods here

  15. List of reports in the field of reactor safety research of BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning single problems in the field of Reactor Safety Research. According to the cooperation of the Bundesminister fuer Forschung und Technologie (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programme of the BMFT, reporting organization. The list of reports appears quarterly. (orig.)

  16. Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients.

    Science.gov (United States)

    Dai, Danian; Chen, Bo; Tang, Hailin; Wang, Bin; Zhao, Zhiping; Xie, Xiaoming; Wei, Weidong

    2016-01-01

    Previous studies have indicated that carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) levels are both independent prognostic factors in breast cancer. However, the utility of CEA and CA15-3 levels as conventional cancer biomarkers in patients with triple-negative breast cancer (TNBC) remains controversial. The current study was performed to explore the predictive value of pre-therapeutic serum CEA and CA15-3 levels, and nomograms were developed including these serum cancer biomarkers to improve the prognostic evaluation of TNBC patients. Pre-therapeutic CA15-3 and CEA concentrations were measured in 247 patients with stage I-IV TNBC. Kaplan-Meier analysis showed that TNBC patients with high levels of both CEA and CA15-3 had shorter overall survival (OS) and disease-free survival (DFS) rates than those in the low-level groups (ppersonal forecasts of OS and DFS for patients with TNBC. These novel nomograms may help physicians to select the optimal treatment plans to ensure the best outcomes for TNBC patients. PMID:27561099

  17. Concomitant hepatic radiation and intraarterial fluorinated pyrimidine therapy: correlation of liver scan, liver function tests, and plasma CEA with tumor response

    International Nuclear Information System (INIS)

    Sixteen patients with metastatic disease to the liver (12 colorectal and four unknown primary tumors) were treated in a pilot study of hepatic irradiation (2500-3000 rads in 10-12 fractions) delivered concomitantly with continuous short-term intraarterial infusion of 5-fluorouracil (1 g/d) or FUDR (0.5 mg/kg/d) via a percutaneously placed hepatic artery catheter. Abnormal liver function tests, including SGOT, LDH, and alkaline phosphatase, decreased in all patients by day 7-10 of treatment, and other metabolic factors, including serum cholesterol, calcium, albumin, phosphorous, and uric acid, also decreased, often to subnormal levels by termination of treatment (day 15-20). These chemical alterations did not correlate with tumor response in that the identical pattern was observed in responders (ten patients) as well as nonresponders (six patients). Objective determinants of response were assessed by serial monitoring of the plasma carcinoembryonic antigen (CEA) and liver scan. In 14 patients with elevated CEA levels, tumor response (nine patients), nonresponse (four patients), and relapse (five patients) was predicted and confirmed by sequential monitoring of CEA. In one patient, a paradoxical decrease in plasma CEA was associated with progressive disease. The liver scan identified all responding patients but was difficult to quantitate and was delayed for months following subjective clinical response and changes in plasma CEA levels

  18. Clinical significance of combined detection of CYFRA21-1, NSE and CEA in classification and staging of patients with lung cancer

    International Nuclear Information System (INIS)

    To explore clinical value of combined detection of CYFRA21-1, NSE and CEA in classification and staging of patients with lung cancer, the CYFRA21-1, NSE and CEA levels in pleural effusion in 330 patients with lung cancer and in 43 patients with benign were detected by the electrochemiluminescence. The results showed that CYFRA21-1, NSE and CEA levels in pleural effusion in patients with lung cancer group were significantly higher than that of in benign group (P<0.01). The positive rate of tumor markers in different pathological type lung cancer were different,which CYFRA21-1 positive rate in squamous cell cancer group was highest with 65.5%; CEA positive rate in glands cancer group was supreme with 65.0%; the NSE positive rate in differentiation cancer group was highest with 79.5%. The positive rate in three markers combined detection was higher than that in one item detection. The tumor marker levels in lung cancer were positively related with clinical staging. The higher of tumor marker levels and the more late of clinical staging, and the clinical III∼IV period was obviously higher than that I∼II period (P<0.05). The combined detection of CYFRA21-1, NSE and CEA may enhance the positive rate in lung cancer detection, and may have significant clinical value in the classification and staging of patients with lung cancer. (authors)

  19. The importance of preoperative elevated serum levels of CEA and CA15-3 in patients with breast cancer in predicting its histological type.

    Directory of Open Access Journals (Sweden)

    J Słonina

    2010-06-01

    Full Text Available It is not known whether in patients with breast cancer the occurrence of elevated serum tumour markers depends on its histological type. The aim of the study was to assess relationship between breast cancer histological type and the presence of increased serum levels of CEA and CA 15-3. The study population was 428 patients (all women, mean age 52.5 years, treated at The Department of Surgery of Wroclaw Medical University from 2005 to 2008 due to breast cancer. All of them had their preoperative CA 15-3 and CEA serum concentrations measured. According to the TNM system, 21% of patients were in stage I, 32.5% in stage II, 46.5% in stage III of the disease. In patients with ductal type of the cancer the elevated serum levels of CEA and CA 15-3 were observed in 48.7% and 42.2%, in lobular type in 42.4% and 52.5%, and in non-ductal/tubular types in 48.1% and 40.4% (p=N/S. Stepwise logistic regression analyses showed that ductal breast cancer is related to elevated CEA and normal CA 15-3 serum levels. The histological types of breast cancer are not significantly related to elevated serum levels of CEA and/or CA 15-3.

  20. Relationship between peripheral and mesenteric serum levels of CEA and CA 242 with staging and histopathological variables in colorectal adenocarcinoma Níveis séricos periféricos e mesentéricos de CEA e CA 242, estadiamento e variáveis histopatológicas no adenocarcinoma colorretal

    OpenAIRE

    Mauro Lamelas Cardoso; Luís Cesar Fernandes; Su Bong Kim; Delcio Matos

    2009-01-01

    PURPOSE: To compare histopathological variables and staging in colorectal adenocarcinoma cases with CEA and CA 242 in peripheral and mesenteric blood. METHODS: In 169 individuals underwent surgery for colorectal cancer, CEA and CA 242 were analyzed and compared to mesenteric and peripheral blood and correlated with macroscopic tumor's morphology and size, degree of cell differentiation, venous, neural and lymphatic involvement and TNM classification. RESULTS: There was a difference between th...

  1. Ultrasensitive sandwich-type electrochemical immunosensor based on trimetallic nanocomposite signal amplification strategy for the ultrasensitive detection of CEA

    Science.gov (United States)

    Tian, Lihui; Liu, Li; Li, Yueyuan; Wei, Qin; Cao, Wei

    2016-01-01

    A novel and ultrasensitive sandwich-type electrochemical immunosensor was designed for the quantitative detection of carcino-embryonic antigen (CEA). This immunosensor was developed by using the trimetallic NiAuPt nanoparticles on graphene nanosheets (NGs) nanosheets (NiAuPt-NGs) as excellent labels and β-cyclodextrin functionalized reduced graphene oxide nanosheets (CD-NGs) as the platform. The CD-NGs with high specific surface area good biocompatibility and the ideal dispersibility was used to capture the primary antibodies (Ab1) efficiently. The trimetallic NiAuPt-NGs nanocomposites were used as the labels for signal amplification, showing better electrocatalytic activity towards the reduction of hydrogen peroxide (H2O2), which is much better than that the monometallic Pt-NGs, bimetallic NiPt-NGs and AuPt-NGs due to the synergetic effect presented in NiAuPt-NGs. The NiAuPt-NGs nanocomposites consist of tightly coupled nanostructures of Au, Ni and Pt, which have neither an alloy nor a core-shell structure. Under the optimal conditions, a linear range from 0.001–100 ng/mL and a low detection limit of 0.27 pg/mL were obtained for CEA. The proposed electrochemical sandwich-type immunosensor may have a promising application in bioassay and it enriches the electrochemical immunoassays. PMID:27488806

  2. Neutron Activation and Thermoluminescent Detector Responses to a Bare Pulse of the CEA Valduc SILENE Critical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McMahan, Kimberly L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Yi-kang [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Gagnier, Emmanuel [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Authier, Nicolas [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Piot, Jerome [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Jacquet, Xavier [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Rousseau, Guillaume [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Reynolds, Kevin H. [Oak Ridge Y-12 Plant (Y-12), Oak Ridge, TN (United States)

    2015-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 11, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  3. Diagnostic value of combined determination of serum tumor markers (NSE, CA-242, TPA, CEA) levels in patients with lung cancer

    International Nuclear Information System (INIS)

    Objective: To investigate the diagnostic value of combined determination of serum NSE, CA242, tissue polypeptide antigen (TPA) and CEA levels in patients with primary lung cancer. Methods: Serum NSE, CA242, TPA and CEA levels were determined with ELISA in (1) 102 patients with various types of primary lung carcinoma (adenocarcinoma 38, squamous cell carcinoma 32, small cell lung carcinoma 32) (2) 33 patients with open lung T. B. and (3) 30 controls. Results: (1) In patients with lung cancer, serum levels of all the four markers were increased and significantly higher than their respective values in patients with open lung T.B. and controls. (2) Positive rate of combined any two markers were 75% for adenocarcinoma, 50% for squamous cell carcinoma and 65% for small cell lung carcinoma, while false positive rate was only 9% for T.B patients and none for the controls. (3) The most appropriate single marker for each specific type of lung cancer was: NSE for SCLC (sensitivity 72%, specificity 97%, CA242 for adenocarcinoma sensitivity 62%, specificity 90%). Conclusion: Combined determination of these tumor markers would improve the sensitivity and specificity for diagnosis of primary lung carcinoma. (authors)

  4. Ultrasensitive sandwich-type electrochemical immunosensor based on trimetallic nanocomposite signal amplification strategy for the ultrasensitive detection of CEA.

    Science.gov (United States)

    Tian, Lihui; Liu, Li; Li, Yueyuan; Wei, Qin; Cao, Wei

    2016-01-01

    A novel and ultrasensitive sandwich-type electrochemical immunosensor was designed for the quantitative detection of carcino-embryonic antigen (CEA). This immunosensor was developed by using the trimetallic NiAuPt nanoparticles on graphene nanosheets (NGs) nanosheets (NiAuPt-NGs) as excellent labels and β-cyclodextrin functionalized reduced graphene oxide nanosheets (CD-NGs) as the platform. The CD-NGs with high specific surface area good biocompatibility and the ideal dispersibility was used to capture the primary antibodies (Ab1) efficiently. The trimetallic NiAuPt-NGs nanocomposites were used as the labels for signal amplification, showing better electrocatalytic activity towards the reduction of hydrogen peroxide (H2O2), which is much better than that the monometallic Pt-NGs, bimetallic NiPt-NGs and AuPt-NGs due to the synergetic effect presented in NiAuPt-NGs. The NiAuPt-NGs nanocomposites consist of tightly coupled nanostructures of Au, Ni and Pt, which have neither an alloy nor a core-shell structure. Under the optimal conditions, a linear range from 0.001-100 ng/mL and a low detection limit of 0.27 pg/mL were obtained for CEA. The proposed electrochemical sandwich-type immunosensor may have a promising application in bioassay and it enriches the electrochemical immunoassays. PMID:27488806

  5. The current CEA/DRN safety approach for the design and the assessment of future nuclear installations

    International Nuclear Information System (INIS)

    The purpose of the document is to present the basis of the safety approach currently implemented by the CEA/DRN, both for the design and the assessment of innovative systems and future nuclear installations. This approach is the result of the experience maturated, within the context of the CEA/DRN Innovative Programme through practical applications over several future concepts, both for fission and fusion reactors, as well as for waste disposal. The background of this experience is structured coherently with the European Safety Authorities recommendations and the European Utilities Requirements (EUR). The Defence In Depth principle and its application, by means, among others, of the barrier concept, remains the basis of the safety design process of future nuclear installations. Its adequacy is checked through the safety assessment. The methodology for Lines Of Defence (LOD) implementation as well as the one for the LOD architecture assessment is shown and motivated. The document shows that the clear and unambiguous definition of the safety approach provides an essential base for the organisation of the design tasks, being sure that the safety aspects are correctly taken into account and implemented, and for an adequate safety assessment of the final design, both from qualitative point of view as well as for the quantitative safety analysis. (author)

  6. Low dose radiation effects: an integrative european approach (Risc-Rad Project) coordinated by the Cea

    International Nuclear Information System (INIS)

    RISC-RAD (Radiosensitivity of Individuals and Susceptibility to Cancer induced by ionizing Radiations) is an Integrated Project funded by the European Commission under 6. Framework Programme / EURATOM. RISC-RAD started on 1. January 2004 for a duration of four years. Coordinated by Cea (Dr Laure Sabatier), it involves 11 European countries (Austria, Denmark, Finland, France, Germany, Ireland, Italy, the Netherlands, Spain, Sweden and the United Kingdom) and 29 research institutions. Objectives: Exposures to low and protracted doses of ionizing radiation are very frequent in normal living environment, at work places, in industry and in medicine. Effects of these exposures on human health cannot be reliably assessed by epidemiological methods, nor is thoroughly understood by biologists. RISC-RAD project proposes to help bridging the gap of scientific knowledge about these effects. To achieve this goal, a necessary key step is to understand the basic mechanisms by which radiation induces cancer. Studying this multistage process in an integrated way, the project offers a new biological approach characterised by and clear-cut and objective-driven scientific policy: the project is focused on the effects of low doses (less than 100 mSv) and protracted doses of radiation. It aims at identifying new parameters that take into account the differences in radiation responses between individuals. A group of modelers works closely with the experimental teams in order to better quantify the risks associated with low and protracted doses. Research work is divided into five work packages interacting closely with each other. WP1 is dedicated to DNA damage. Ionizing Radiation (IR) produce a broad spectrum of base modifications and DNA strand breaks of different kinds, among which double-strand breaks and 'clustered damage' which is thought to be a major feature in biological effectiveness of IR. The aim of Work Package 1 is to improve understanding of the initial DNA damage induced by

  7. Clinical significance of combined determination of several tumor markers (including CYFRA21-1, NSE, CA-50 and CEA) in patients with pulmonary cancer

    International Nuclear Information System (INIS)

    Objective: To enhance the diagnosis of pulmonary cancer by determination of optimal combinations of various tumor markers. Methods: Serum CYFRA21-1, NSE, CA-50 (with RIA) and CEA (with CLIA) contents were determined in 107 patients with various types of pulmonary cancers, 66 patients with various benign pulmonary diseases and 59 controls. Results: It was revealed that CYFRA21-1 determination was most sensitive for detection of squamous cell carcinoma. The same was true for CEA in the detection of adenocarcinoma. NSE determination was very specific for small cell carcinoma. Combined determinations of either CYFRA21-l + NSE or CYFRA21-1 + NSE + CEA were excellent for general screening. Conclusion: Combined determination of these tumor markers could be applied expediently as supplementary diagnostic measure for pulmonary malignancies. (authors)

  8. Efeito do posicionamento da necromassa de herbáceas no processo de decomposição e libertação de nutrientes.

    OpenAIRE

    Santos-Silva, Celeste; Madeira, Manuel; Gazarini, Luiz

    2005-01-01

    Estudou-se a influência do posicionamento da necromassa de herbáceas, à superfície e a 10 cm de profundidade do solo, no processo de decomposição e libertação de nutrientes. Para o efeito, colheu-se no Verão de 1998 a necromassa de herbáceas que cresceram em zonas de montado numa área experimental na região de Évora. O estudo da decomposição teve início em Janeiro de 1999 e decorreu durante dois anos. A taxa de decomposição da necromassa das herbáceas, calculada para os dois anos de estudo...

  9. Value of {sup 18}F-FDG uptake on PET/CT and CEA level to predict epidermal growth factor receptor mutations in pulmonary adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Kai-Hsiung; Hsu, Hsian-He; Chang, Wei-Chou; Hsu, Yi-Chih; Chang, Tsun-Hou [Tri-Service General Hospital and National Defense Medical Center, Department of Radiology, Taipei 114 (China); Huang, Tsai-Wang; Chang, Hung [Tri-Service General Hospital and National Defense Medical Center, Department of Thoracic Surgery, Taipei (China); Gao, Hong-Wei [Tri-Service General Hospital and National Defense Medical Center, Department of Pathology, Taipei (China); Shen, Daniel H.Y. [Tri-Service General Hospital and National Defense Medical Center, Department of Nuclear medicine, Taipei (China); Chu, Chi-Ming [Institute of Public Health, National Defense Medical Center and University, Section of Health Informatics, Taipei (China); Ho, Ching-Liang [Tri-Service General Hospital and National Defense Medical Center, Division of Hematology-Oncology, Department of Internal Medicine, Taipei (China)

    2014-10-15

    The identification of the mutation status of the epidermal growth factor receptor (EGFR) is important for the optimization of treatment in patients with pulmonary adenocarcinoma. The acquisition of adequate tissues for EGFR mutational analysis is sometimes not feasible, especially in advanced-stage patients. The aim of this study was to predict EGFR mutation status in patients with pulmonary adenocarcinoma based on {sup 18}F-fluorodeoxyglucose (FDG) uptake and imaging features in positron emission tomography/computed tomography (PET/CT), as well as on the serum carcinoembryonic antigen (CEA) level. We retrospectively reviewed 132 pulmonary adenocarcinoma patients who underwent EGFR mutation testing, pretreatment FDG PET/CT and serum CEA analysis. The associations between EGFR mutations and patient characteristics, maximal standard uptake value (SUVmax) of primary tumors, serum CEA level and CT imaging features were analyzed. Receiver-operating characteristic (ROC) curve analysis was performed to quantify the predictive value of these factors. EGFR mutations were identified in 69 patients (52.2 %). Patients with SUVmax ≥6 (p = 0.002) and CEA level ≥5 (p = 0.013) were more likely to have EGFR mutations. The CT characteristics of larger tumors (≥3 cm) (p = 0.023) and tumors with a nonspiculated margin (p = 0.026) were also associated with EGFR mutations. Multivariate analysis showed that higher SUVmax and CEA level, never smoking and a nonspiculated tumor margin were the most significant predictors of EGFR mutation. The combined use of these four criteria yielded a higher area under the ROC curve (0.82), suggesting a good discrimination. The combined evaluation of FDG uptake, CEA level, smoking status and tumor margins may be helpful in predicting EGFR mutation status in patients with pulmonary adenocarcinoma, especially when the tumor sample is inadequate for genetic analysis or genetic testing is not available. Further large-scale prospective studies are

  10. Clinical value of CEA and CYFRA 21-1 for the differentiation of benign and malignant pleural effusion by Meta analysis

    International Nuclear Information System (INIS)

    Objective: Pleural effusion is a common clinical complication caused by many benign or malignant diseases. Many published papers presented that tumor-marker assays, such as carcinoembryonic antigen (CEA) and cytokeratin 19 fragment antigen 21-1 (CYFRA 21-1), played a vital role on the benign and malignant differentiation. This study aimed to reviewe currently available published papers to evaluate the clinical value of these two markers for the differentiation of benign and malignant pleural effusion. Methods: All published data of pleural effusion CEA and CYFRA 21-1 for the differentiation studies from year 1996 to 2007 were reviewed. By methodological qualities and Q test, 19 papers were selected into this study. The overall diagnostic sensitivity, specificity, and area under curve (AUC) from receiver operating characteristic (ROC) curve were adopted to compare the value of pleural effusion CEA and CYFRA 21-1 for benign and malignant differentiation used Z test. Results: There were 3228 subjects included in this Meta-analysis. The sensitivity and specificity [95% confidence interval (CI)] of CEA were 45.9% (43.2%-48.5%) and 97.0% (96.0%-97.8%), and of CYFRA 21-1, 47.3% (44.0%-50.6%) and 91.8% (89.5%-93.7%). AUC of CEA and CYFRA 21-1 were 0.7691 and 0.8213 respectively (Z=0.45, P>0.05). Conclusion: Both CEA and CYFRA 21-1 are useful for the differentiation of benign and malignant pleural effusion. (authors)

  11. High Plasma TIMP-1 and Serum CEA Levels during Combination Chemotherapy for Metastatic Colorectal Cancer Are Significantly Associated with Poor Outcome

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Byström, Per; Berglund, Ake;

    2010-01-01

    Objective: To evaluate whether combination chemotherapy leads to early changes in plasma TIMP-1 and serum carcinoembryonic antigen (CEA) levels in patients with metastatic colorectal cancer (mCRC), and whether such changes relate to subsequent objective response, time to progression (TTP) and...... response. Moreover, high levels of plasma TIMP-1 before treatment and at weeks 2 and 4 were significantly associated with short TTP, while high levels of serum CEA at week 4 were significantly associated with short TTP. Finally, high levels of plasma TIMP-1 before and during treatment were significantly...

  12. Special document: which energies for tomorrow? Fossil, renewable, nuclear, hydrogen energies; the CEA of Saclay at the heart of the research; energy, greenhouse effect, climate

    International Nuclear Information System (INIS)

    The Cea devotes many research programs in the energy domain and especially in the development of new energetic solutions: hydrogen program, photovoltaic program, energy conservation domain and improvement of energy production systems. In this framework, this document presents synthetical information on the France situation in the world energy space and on the Cea Saclay researches. The energy policy and the electric power in France, the fossil energies, the nuclear energy, the renewable energies, the hydrogen and the fuel cell, the greenhouse effect and the climatology are detailed. (A.L.B.)

  13. Enraizamento de estacas herbáceas de guaranazeiro em diferentes substratos Survival rate of guarana herbaceous cuttings in different substrates

    OpenAIRE

    Murilo Rodrigues de Arruda; José Clério Rezende Pereira; Adônis Moreira; Wenceslau Geraldes Teixeira

    2007-01-01

    A utilização de sementes na propagação do guaranazeiro propicia alta variabilidade na produtividade e suscetibilidade a doenças, por isto, no Amazonas, recomenda-se a propagação do guaranazeiro por meio do enraizamento de estacas herbáceas de materiais selecionados. Objetivou-se com este trabalho, avaliar o enraizamento, em tubetes, de estacas herbáceas de doze clones de guaranazeiro submetidas a três diferentes substratos. Os clones avaliados foram o BRS 300, BRS 871, BRS 372, BRS 648, BRS 1...

  14. DISTRIBUCIÓN ACTUAL Y POTENCIAL DE LAS CACTÁCEAS FEROCACTUS HISTRIX, MAMMILLARIA BOMBYCINA Y M. PEREZDELAROSAE EN EL ESTADO DE AGUASCALIENTES, MÉXICO

    OpenAIRE

    Ernestina Meza-Rangel; Felipe Tafoya; Roberto Lindig-Cisneros; Jos\\u00E9 Jes\\u00FAs Sigala-Rodr\\u00EDguez; Eugenio P\\u00E9rez-Molphe-Balch

    2014-01-01

    Las cactáceas en México son un grupo representativo de las zonas áridas que actualmente presenta problemas de conservación debido a la sobreexplotación y el saqueo de los que han sido objeto en todo el país. En este trabajo se reporta la distribución actual de tres especies de cactáceas en el estado de Aguascalientes actualmente sujetas a protección especial según la legislación ambiental federal mexicana (Ferocactus histrix, Mammillaria bombycina y M. perezdelarosae). Se estimó su distribuci...

  15. INIS - International Nuclear Information System. CEA-users relations. Nuclear information in total freedom; INIS - International Nuclear Information System. Relations CEA utilisateurs. L'information nucleaire en toute liberte

    Energy Technology Data Exchange (ETDEWEB)

    Surmont, J.; Paillard, M.D.; Constant, A.; Guille, N.; Le Blanc, A.; Mouffron, O.; Anguise, P.; Jouve, J.J.; Lilin, A

    2009-07-01

    This poster, prepared for the seventh edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents the principle of operation of the INIS system, based on a cooperative and decentralized preparation of the data which are centralized by the IAEA for the preparation of the INIS products: the database (on Internet and on CD/DVD-Rom), the collection of grey literature documents in full text (microfiches and CD/DVD-roms), and the multilingual thesaurus available in 7 different languages and under various formats. The poster presents these different products, and the role of the INIS members in the distribution of these products towards their national users. One insert presents the French INIS team of the CEA-Saclay and its daily work. (J.S.)

  16. Pharmacokinetics and Dosimetry Studies for Optimization of Pretargeted Radioimmunotherapy in CEA-Expressing Advanced Lung Cancer Patients

    Directory of Open Access Journals (Sweden)

    Caroline eBodet-Milin

    2015-11-01

    Full Text Available Objectives. A phase I pretargeted radioimmunotherapy trial (EudractCT 200800603096 was designed in patients with metastatic lung cancer expressing carcinoembryonic antigen (CEA to optimize bispecific antibody and labelled peptide doses, as well as the delay between their injections.Methods. Three cohorts of 3 patients received the anti-CEA x anti-histamine-succinyl-glycine (HSG humanized trivalent bispecific antibody (TF2 and the IMP288 bivalent HSG-peptide. Patients underwent a pre-therapeutic imaging session S1 (44 or 88 nmol/m2 of TF2 followed by 4.4 nmol/m2, 185 MBq, of 111In-labelled IMP288, and, 1-2 weeks later, a therapy session S2 (240 or 480 nmol/m2 of TF2 followed by 24 nmol/m2, 1.1 GBq/m2, 177Lu-labeled IMP288. The pretargeting delay was 24 or 48 hours. The dose schedule was defined based on pre-clinical TF2 pharmacokinetic studies, on our previous clinical data using the previous anti-CEA pretargeting system and on clinical results observed in the first patients injected using the same system in the Netherlands.Results. TF2 pharmacokinetics (PK was represented by a two-compartment model in which the central compartment volume was linearly dependent on the patient's surface area. PK were remarkably similar, with a clearance of 0.33 +/- 0.03 L/h per m2. 111In- and 177Lu-IMP288 PK were also well represented by a two-compartment model. IMP288 PK were faster (clearance 1.4 to 3.3 l/h. The central compartment volume was proportional to body surface area and IMP288clearance depended on the molar ratio of injected IMP288 to circulating TF2 at the time of IMP288 injection. Modelling of image quantification confirmed the dependence of IMP288 kinetics on circulating TF2, but tumour activity PK were variable. Organ absorbed doses were not significantly different in the 3 cohorts, but the tumour dose was significantly higher with the higher molar doses of TF2 (p < 0.002. S1 imaging predicted absorbed doses calculated in S2. Conclusion. The best

  17. Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers

    International Nuclear Information System (INIS)

    Human monoclonal antibodies (MAbs) are needed for colon cancer radioimmunotherapy (RIT) to allow for repeated injections. Carcinoembryonic antigen (CEA) being the reference antigen for immunotargeting of these tumors, we developed human anti-CEA MAbs. XenoMouse®-G2 animals were immunized with CEA. Among all the antibodies produced, two of them, VG-IgG2κ and VG-IgM, were selected for characterization in vitro in comparison with the human-mouse chimeric anti-CEA MAb X4 using flow cytometry, surface plasmon resonance, and binding to radiolabeled soluble CEA and in vivo in human colon carcinoma LS174T bearing nude mice. Flow cytometry analysis demonstrated binding of MAbs on CEA-expressing cells without any binding on NCA-expressing human granulocytes. In a competitive binding assay using five reference MAbs, directed against the five Gold CEA epitopes, VG-IgG2κ and VG-IgM were shown to be directed against the Gold 4 epitope. The affinities of purified VG-IgG2κ and VG-IgM were determined to be 0.19 ± 0.06 × 108 M-1 and 1.30 ± 0.06 × 108 M-1, respectively, as compared with 0.61 ± 0.05 × 108 M-1 for the reference MAb X4. In a soluble phase assay, the binding capacities of VG-IgG2κ and VG-IgM to soluble CEA were clearly lower than that of the control chimeric MAb X4. A human MAb concentration of about 10-7 M was needed to precipitate approximatively 1 ng 125I-rhCEA as compared with 10-9 M for MAb X4, suggesting a preferential binding of the human MAbs to solid phase CEA. In vivo, 24 h post-injection, 125I-VG-IgG2κ demonstrated a high tumor uptake (25.4 ± 7.3%ID/g), close to that of 131I-X4 (21.7 ± 7.2%ID/g). At 72 h post-injection, 125I-VG-IgG2κ was still concentrated in the tumor (28.4 ± 11.0%ID/g) whereas the tumor concentration of 131I-X4 was significantly reduced (12.5 ± 4.8%ID/g). At no time after injection was there any accumulation of the radiolabeled MAbs in normal tissues. A pertinent analysis of VG-IgM biodistribution was not possible in this

  18. Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA Gold 4 epitope and designed for radioimmunotherapy (RIT of colorectal cancers

    Directory of Open Access Journals (Sweden)

    Pugnière Martine

    2004-10-01

    Full Text Available Abstract Background Human monoclonal antibodies (MAbs are needed for colon cancer radioimmunotherapy (RIT to allow for repeated injections. Carcinoembryonic antigen (CEA being the reference antigen for immunotargeting of these tumors, we developed human anti-CEA MAbs. Methods XenoMouse®-G2 animals were immunized with CEA. Among all the antibodies produced, two of them, VG-IgG2κ and VG-IgM, were selected for characterization in vitro in comparison with the human-mouse chimeric anti-CEA MAb X4 using flow cytometry, surface plasmon resonance, and binding to radiolabeled soluble CEA and in vivo in human colon carcinoma LS174T bearing nude mice. Results Flow cytometry analysis demonstrated binding of MAbs on CEA-expressing cells without any binding on NCA-expressing human granulocytes. In a competitive binding assay using five reference MAbs, directed against the five Gold CEA epitopes, VG-IgG2κ and VG-IgM were shown to be directed against the Gold 4 epitope. The affinities of purified VG-IgG2κ and VG-IgM were determined to be 0.19 ± 0.06 × 108 M-1 and 1.30 ± 0.06 × 108 M-1, respectively, as compared with 0.61 ± 0.05 × 108 M-1 for the reference MAb X4. In a soluble phase assay, the binding capacities of VG-IgG2κ and VG-IgM to soluble CEA were clearly lower than that of the control chimeric MAb X4. A human MAb concentration of about 10-7 M was needed to precipitate approximatively 1 ng 125I-rhCEA as compared with 10-9 M for MAb X4, suggesting a preferential binding of the human MAbs to solid phase CEA. In vivo, 24 h post-injection, 125I-VG-IgG2κ demonstrated a high tumor uptake (25.4 ± 7.3%ID/g, close to that of 131I-X4 (21.7 ± 7.2%ID/g. At 72 h post-injection, 125I-VG-IgG2κ was still concentrated in the tumor (28.4 ± 11.0%ID/g whereas the tumor concentration of 131I-X4 was significantly reduced (12.5 ± 4.8%ID/g. At no time after injection was there any accumulation of the radiolabeled MAbs in normal tissues. A pertinent analysis of

  19. From basic science to social issue: the CEA's role in nuclear energy and alternative sources of energy

    International Nuclear Information System (INIS)

    By force of circumstance, thoroughgoing changes are under way in the ways we consume and produce energy. Research and development must respond to these changes by making technological innovations and proposing solutions that are safe, competitive, economic with regard to natural resources and respectful of the environment. The French ''Commissariat a l'Energie Atomique et aux energies alternatives'' (CEA) has a leading role to play through its large range of activities: fundamental research and technological research in various fields from biology to nuclear sciences via energy efficiency of buildings and solar energy and through its access to big experimental facilities like Orphee and Osiris reactors or peta-watt Lasers or Soleil synchrotron

  20. List of reports of BMFT, CEA, EPRI, JSTA and USNRC in the field of reactor safety research

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning special problems in the field of Reactor Safety Research. According to the cooperation of the Bundesminister fuer Forschung und Technologie (BMFT) with the Commisariat a l'Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electrical Power Research Institute (EPRI) and the United States Nuclear Regulatory Commision, these reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programm of the BMFT, reporting organization. The list of reports appears quaterly. (orig./HP)

  1. List of reports in the field of reactor safety research of BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning single problems in the field of reactor safety research. According to the cooperation of the Federal Minister for Research and Technology (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Program of the BMFT, reporting organization. The list of reports appears quarterly. (orig./HP)

  2. Overview of the long-lived radionuclide separation processes developed in connection with the CEA's spin programme

    International Nuclear Information System (INIS)

    One possible strategy for eliminating the long-term potential hazards associated with the storage of vitrified high level waste produced by the processing of irradiated nuclear fuels, is the transmutation of the long-life radionuclides in these wastes into short-life radionuclides by nuclear means, which requires the prior chemical separation of these long-life radionuclides from the nuclear waste mixture. To do this, the French CEA (Atomic Energy Commissionership) launched the SPIN (Separation-Incineration) research programme in 1991, under the law passed by the parliament on december 30, 1991. Research currently under way to develop separation processes for some long-life radionuclides concerns modifications of the Purex process, and the development of new solvent extraction processes. The research directions are briefly summarized here. (authors). 17 refs., 3 tabs

  3. Fusion reactor technology studies common development activities of CEA and KFK in the frame of the european community fusion programme

    International Nuclear Information System (INIS)

    In 1982, it was decided in the European Community to complement the fusion programme by a technology part. The initial content of this technology programme was defined by European experts. The laboratories associated to Euratom were invited to participate with proposals, which were then selected by the Fusion Technology Steering Committee. Coherent with these activities, steps were taken to define the next generation of fusion experiments by the newly founded Next European Torus (NET) Team. To contribute in the most efficient way, CEA and KfK have agreed to cooperate by complementary activities, common experiments and by forming common research groups. The particular agreements have been kept open for partners from other EC laboratories to join. The different cooperative activities in the field of nuclear technologies are described below together with first results and findings

  4. List of reports in the field of reactor safety research from BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning single problems in the field of reactor safety research. According to the cooperation of the Bundesminister fuer Forschung und Technologie (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Program of the BMFT, reporting organization. The list of reports appears quarterly. (orig./HP)

  5. List of reports in the field of reactor safety research sponsored by BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    The list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning single problems in the field of reactor safety research. According to the cooperation of the Federal Minister for Research and Technology (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programme of the BMFT, reporting organization. The list of reports appears quarterly. (orig.) With 142 refs

  6. Overview of CEA's R&D on GFR fuel element design: from challenges to solutions

    International Nuclear Information System (INIS)

    Over the period 2002-2012, CEA conducted some extensive R&D on the design of GFR fuel elements (together with related material and core/system studies). This paper reviews the challenges raised by this programme, the solutions proposed to address them, and the remaining issues. Studies were performed on the assembly duct, the pin bundle and the fuel pin. The main issues were related to the challenge of using silicon carbide composites (SiC/SiC) for the pin cladding and the assembly duct, as well as mixed uranium-plutonium carbide (UPuC) for the nuclear fuel. Emphasizing the pin design, key achievements are reviewed in this paper regarding such topics as fission product confinement and high burnup performance, for the sake of which original design options were recently patented. (author)

  7. Terahertz Real-Time Imaging Uncooled Arrays Based on Antenna-Coupled Bolometers or FET Developed at CEA-Leti

    Science.gov (United States)

    Simoens, François; Meilhan, Jérôme; Nicolas, Jean-Alain

    2015-10-01

    Sensitive and large-format terahertz focal plane arrays (FPAs) integrated in compact and hand-held cameras that deliver real-time terahertz (THz) imaging are required for many application fields, such as non-destructive testing (NDT), security, quality control of food, and agricultural products industry. Two technologies of uncooled THz arrays that are being studied at CEA-Leti, i.e., bolometer and complementary metal oxide semiconductor (CMOS) field effect transistors (FET), are able to meet these requirements. This paper reminds the followed technological approaches and focuses on the latest modeling and performance analysis. The capabilities of application of these arrays to NDT and security are then demonstrated with experimental tests. In particular, high technological maturity of the THz bolometer camera is illustrated with fast scanning of large field of view of opaque scenes achieved in a complete body scanner prototype.

  8. List of reports in the field of reactor safety research sponsored by BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning single problems in the field of reactor safety research. According to the cooperation of the Federal Minister for Research and Technology (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programm of the BMFT, reporting organization. The list of reports appears quarterly. (orig./HP)

  9. Improvements on Low Level Activity Gamma Measurements and X-ray Spectrometry at the CEA-MADERE Measurement Platform

    Science.gov (United States)

    Sergeyeva, Victoria; Domergue, Christophe; Destouches, Christophe; Girard, Jean Michel; Philibert, Hervé; Bonora, Jonathan; Thiollay, Nicolas; Lyoussi, Abdallah

    2016-02-01

    The CEA MADERE platform (Measurement Applied to DosimEtry in REactors) is a part of the Instrumentation Sensors and Dosimetry Laboratory (LDCI). This facility is dedicated to the specific activity measurements of solid and radioactive samples using Gamma and X-ray spectrometry. MADERE is a high-performance facility devoted to neutron dosimetry for experimental programs performed in CEA and for the irradiation surveillance programmes of PWR vessels. The MADERE platform is engaged in a continuous improvement process. Recently, two High Efficiency diodes have been integrated to the MADERE platform in order to manage the accurate low level activity measurements (few Bq per sample). This new equipment provides a good level of efficiency over the energy range from 60 keV to 2 MeV. The background continuum is reduced due to the use of a Ultra Low Background (ULB) lead shielding. Relative and absolute X-ray measurement techniques have been improved in order to facilitate absolute rhodium activity measurement (Rh103m) on solid samples. Additional efforts have been made to increase the accuracy of the relative niobium (Nb93m) activity measurement technique. The way of setting up an absolute measurement method for niobium is under investigation. After a presentation of the MADERE's measurement devices, this paper focuses on the technological options taken into account for the design of high efficiency measurement devices. Then, studies performed on X-ray measurement techniques are presented. Some details about the calculation of uncertainties and correction factors are also mentioned. Finally, future research and development axes are exposed.

  10. Improvements on Low Level Activity Gamma Measurements and X-ray Spectrometry at the CEA-MADERE Measurement Platform

    Directory of Open Access Journals (Sweden)

    Sergeyeva Victoria

    2016-01-01

    Full Text Available The CEA MADERE platform (Measurement Applied to DosimEtry in REactors is a part of the Instrumentation Sensors and Dosimetry Laboratory (LDCI. This facility is dedicated to the specific activity measurements of solid and radioactive samples using Gamma and X-ray spectrometry. MADERE is a high-performance facility devoted to neutron dosimetry for experimental programs performed in CEA and for the irradiation surveillance programmes of PWR vessels. The MADERE platform is engaged in a continuous improvement process. Recently, two High Efficiency diodes have been integrated to the MADERE platform in order to manage the accurate low level activity measurements (few Bq per sample. This new equipment provides a good level of efficiency over the energy range from 60 keV to 2 MeV. The background continuum is reduced due to the use of a Ultra Low Background (ULB lead shielding. Relative and absolute X-ray measurement techniques have been improved in order to facilitate absolute rhodium activity measurement (Rh103m on solid samples. Additional efforts have been made to increase the accuracy of the relative niobium (Nb93m activity measurement technique. The way of setting up an absolute measurement method for niobium is under investigation. After a presentation of the MADERE's measurement devices, this paper focuses on the technological options taken into account for the design of high efficiency measurement devices. Then, studies performed on X-ray measurement techniques are presented. Some details about the calculation of uncertainties and correction factors are also mentioned. Finally, future research and development axes are exposed.

  11. Biodistribution and tumor imaging of an anti-CEA single-chain antibody-albumin fusion protein

    Energy Technology Data Exchange (ETDEWEB)

    Yazaki, Paul J. [Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope, Duarte, CA 91010 (United States)], E-mail: pyazaki@coh.org; Kassa, Thewodros; Cheung, Chia-wei; Crow, Desiree M. [Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope, Duarte, CA 91010 (United States); Sherman, Mark A. [Division of Information Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010 (United States); Bading, James R.; Anderson, Anne-Line J.; Colcher, David; Raubitschek, Andrew [Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope, Duarte, CA 91010 (United States)

    2008-02-15

    Albumin fusion proteins have demonstrated the ability to prolong the in vivo half-life of small therapeutic proteins/peptides in the circulation and thereby potentially increase their therapeutic efficacy. To evaluate if this format can be employed for antibody-based imaging, an anticarcinoembryonic antigen (CEA) single-chain antibody(scFv)-albumin fusion protein was designed, expressed and radiolabeled for biodistribution and imaging studies in athymic mice bearing human colorectal carcinoma LS-174T xenografts. The [{sup 125}I]-T84.66 fusion protein demonstrated rapid tumor uptake of 12.3% injected dose per gram (ID/g) at 4 h that reached a plateau of 22.7% ID/g by 18 h. This was a dramatic increase in tumor uptake compared to 4.9% ID/g for the scFv alone. The radiometal [{sup 111}In]-labeled version resulted in higher tumor uptake, 37.2% ID/g at 18 h, which persisted at the tumor site with tumor: blood ratios reaching 18:1 and with normal tissues showing limited uptake. Based on these favorable imaging properties, a pilot [{sup 64}Cu]-positron emission tomography imaging study was performed with promising results. The anti-CEA T84.66 scFv-albumin fusion protein demonstrates highly specific tumor uptake that is comparable to cognate recombinant antibody fragments. The radiometal-labeled version, which shows lower normal tissue accumulation than these recombinant antibodies, provides a promising and novel platform for antibody-based imaging agents.

  12. Free cancer cell detection in peritoneal cavity in gastric cancer patients by RT-PCR for CEA

    International Nuclear Information System (INIS)

    Authors applied RT-PCR assay to detecting CEA expressing free cancer cells in peritoneal cavity of 114 gastric cancer patients to find an indication for prophylactic treatment to prevent peritoneal recurrence. Sixty-three of 114 cases were positive for RT-PCR, of which 16 cases were positive for cytologic examination and 47 cases were negative. Forty-nine of 51 cases who were negative for RT-PCR were negative for cytologic examination. Positivity for RT-PCR according to the depth of invasion were as follows : two (28.6 %) of seven cases whose cancer invaded mucosal or submucosal layer were positive. Ten (45.5 %) of 22 cases whose cancer invaded muscular or subserosal layer were positive. Forty-one (57.7 %) of 71 serosa involved cases were positive. Eleven (78.6 %) of cases who had grossly perioneal seedings were positive (p=0.026). However, all of 7 EGC cases, 19 of 22 cases whose cancer invaded to muscle layer or to subserosa were negative for cytologic examination, and eight of 13 cases who had had peritoneal seedings were positive. Positivity for RT-PCR according to cell differentiation were as follows: forty-two (61.8 %) of 68 cases who cancer were poorly differentiated type were positive. (p=0.163) Serum level of CEA of RT-PCR positive group and that of negative group were not statistically different. It was revealed that RT-PCR was more sensitive than cytologic examination in detecting free tumor cells, especially in pm, ss and serosa positive cancers, so if further study with more cases and longer follow-up is performed, its role as prognostic factor and an indication of prophylactic therapy will be clarified. (author). 22 refs., 5 tabs

  13. From moon stones to simulation - More than 40 years of experiments on the 7 MV tandem accelerator at Cea/Dam Ile de France

    International Nuclear Information System (INIS)

    Following the decommissioning of the 7 MV tandem accelerator of CEA/DAM by the end of 2007, the present report relates the history of the accelerator from its beginning in the sixties and then the nuclear physics studies on fission, (x,xn) reactions, elastic and inelastic scattering, etc and other studies in microelectronics, biology, etc) performed with that installation. (authors)

  14. Clinical Significance and Prognostic Value of CA72-4 Compared with CEA and CA19-9 in Patients with Gastric Cancer

    Directory of Open Access Journals (Sweden)

    M. Ychou

    2000-01-01

    Full Text Available Carcinoembryonic antigen (CEA and CA 19-9 are both widely used in the follow up of patients with gastrointestinal cancer. More recently another tumor marker, named CA 72-4 has been identified and characterized using two different monoclonal antibodies B72.3 and CC49. Several reports evaluated CA 72-4 as a serum tumor marker for gastric cancer and compared its clinical utility with that of CEA or CA 19-9; few reports concerned its prognostic value. In the present study, CA 72-4 is evaluated and compared with CEA and CA 19-9 in various populations of patients with gastric cancer and benign disease; for 52 patients with gastric adenocarcinoma and 57 patients without neoplastic disease CEA, CA 19-9 and CA 72-4 were evaluated before treatment. Sensitivity of the tumor markers CA 72-4, CA 19-9 and CEA at the recommended cut-off level in all 52 patients were 58%, 50% the sensitivity increased to 75%. of these markers, for non metastatic patients, multivariate analyses indicated that none of the markers were significant, when adjusted for gender and age (which were indicators of poor prognosis; patients with abnormal values of CA72-4 tended to have shorter survival than patients with normal values (p < 0.07. In the metastatic population, only high values of CA19-9 (p < 0.02 and gender (women (p < 0.03 were indicators of poor prognosis in univariate analysis; multivariate analysis revealed that both CA72-4 (p = 0.034 and CA19-9 p = 0.009, adjusted for gender were independent prognostic factors. However, CA72-4 lost significance (p = 0.41 when adjusted for CA19-9 and gender, indicating that CA19-9 provides more prognostic information than CA72-4.

  15. Efeito da cobertura viva com leguminosas herbáceas perenes na agregação de um argissolo

    Directory of Open Access Journals (Sweden)

    A. Perin

    2002-09-01

    Full Text Available O presente trabalho foi desenvolvido na área do Campo Experimental da Embrapa Agrobiologia, Seropédica (RJ, com o objetivo de avaliar a morfologia e a distribuição de raízes de algumas leguminosas herbáceas perenes; os efeitos da cobertura viva no teor de carbono orgânico, e a agregação de um Argissolo Vermelho-Amarelo distrófico, medida pela estabilidade dos agregados em água. O delineamento experimental adotado foi o de blocos casualizados, com três repetições. Os tratamentos consistiram de três diferentes espécies de leguminosas herbáceas perenes e um tratamento-controle sem cobertura viva (capinado. As leguminosas utilizadas foram amendoim forrageiro (Arachis pintoi, cudzu tropical(Pueraria phaseoloides e siratro (Macroptilium Atropurpureum. Para a estabilidade de agregados, as profundidades de amostragem foram 0-5 e 5-10 cm, enquanto, para a morfologia e distribuição radicular, as avaliações consistiram das profundidades 0-5, 5-10, 10-20 e 20-40 cm. As coberturas com as leguminosas amendoim forrageiro e cudzu tropical propiciaram os maiores valores percentuais na classe de agregados > 2,00 mm, em média 38 % superiores aos obtidos na área capinada. Os valores do diâmetro médio ponderado (DMP dos agregados no solo com cobertura de leguminosas foram superiores aos da área capinada para ambas as camadas, o que demonstra o efeito favorável das coberturas vivas na estabilização dos agregados do solo. A cobertura viva de amendoim forrageiro proporcionou incremento no teor de carbono orgânico no solo. Quanto aos atributos morfológicos das raízes, verificou-se que o amendoim forrageiro apresentou raio radicular intermediário entre as demais espécies e área e massa radicular maiores, o que auxiliou na interpretação do efeito positivo da cobertura viva com essa espécie na agregação do solo.

  16. Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral/oropharyngeal squamous cell carcinoma

    Science.gov (United States)

    Yuan, Chuanshu; Yang, Kai; Tang, Hong; Chen, Dan

    2016-01-01

    Background At present, the research on serum tumor markers in the early diagnosis of malignant tumors has aroused widespread concern. The aim of this study was to investigate the diagnostic values of serum tumor markers cytokeratin 19 fragment (Cyfra21-1), squamous cell carcinoma antigen (SCCAg), ferritin, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and α-fetoprotein (AFP) for patients with oral/oropharyngeal squamous carcinoma (OSCC/OPSCC). Methods One hundred and sixty-nine cases of patients with OSCC/OPSCC as the experimental group, 86 cases of oral benign tumor patients as the control group, and 30 cases of healthy people as the normal control group were studied. The levels of serum Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP were measured using electrochemiluminescence immunoassay. Results The levels of serum Cyfra21-1, SCCAg, ferritin, and CEA in patients with OSCC/OPSCC were significantly higher than those of benign tumor and healthy control group (P0.05). The level of serum Cyfra21-1 in patients with early OSCC/OPSCC (stage I + II) was significantly higher than that of benign tumor and healthy control group (P0.05). The levels of serum Cyfra21-1, SCCAg, ferritin, and CEA in the middle-late stage of patients with OSCC/OPSCC (stage III + IV) were significantly higher than those of patients with the early OSCC/OPSCC, benign tumor, and healthy control group (P<0.05). The diagnostic cutoff levels of Cyfra21-1, SCCAg, ferritin, and CEA were 2.17, 0.72, 109.95, and 1.99 ng/mL, respectively. The sensitivities were 60.36%, 73.37%, 81.66%, and 66.27%, respectively. The specificities were 81.03%, 68.10%, 40.52%, and 61.21%, respectively. Conclusion Cyfra21-1, SCCAg, ferritin, and CEA had diagnostic values for patients with OSCC/OPSCC. Meanwhile, Cyfra21-1 had better early diagnostic value for patients with OSCC/OPSCC. PMID:27350753

  17. EURATOM-CEA association contributions to the 26. EPS conference on controlled fusion and plasma physics, Maastricht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-10-15

    This report references the EURATOM-CEA association contributions presented at the 26. EPS conference on controlled fusion and plasma physics, in Maastricht (Netherlands) the 14-18 June 1999. Two invited papers and 24 contributed papers are proposed. They deal with: tokamak devices; particle recirculation in ergodic divertor; current profile control and MHD stability in Tore Supra discharges; edge-plasma control by the ergodic divertor; electron heat transport in stochastic magnetic layer; bolometry and radiated power; particle collection by ergodic divertor; study and simulation of pa impurities; line shape modelling for plasma edge conditions; dynamical study of the radial structure of the fluctuations measured by reciprocating Langmuir probe in Tore Supra; up-down asymmetry of density fluctuations; Halo currents in a circular tokamak; real time measurement of the position, density, profile and current profile at Tore Supra; poloidal rotation measurement by reflectometry; interpretation of q-profile dependence of the LH power deposition profile during LHCD experiments; ICFR plasma production and optimization; improved core electron confinement; measurement of hard X-ray emission profile; modelling of shear effects on thermal and particles transport; ion turbulence; current drive generation based on autoresonance and intermittent trapping mechanisms. (A.L.B.)

  18. EURATOM-CEA association contributions to the 26. EPS conference on controlled fusion and plasma physics, Maastricht

    International Nuclear Information System (INIS)

    This report references the EURATOM-CEA association contributions presented at the 26. EPS conference on controlled fusion and plasma physics, in Maastricht (Netherlands) the 14-18 June 1999. Two invited papers and 24 contributed papers are proposed. They deal with: tokamak devices; particle recirculation in ergodic divertor; current profile control and MHD stability in Tore Supra discharges; edge-plasma control by the ergodic divertor; electron heat transport in stochastic magnetic layer; bolometry and radiated power; particle collection by ergodic divertor; study and simulation of plasma impurities; line shape modelling for plasma edge conditions; dynamical study of the radial structure of the fluctuations measured by reciprocating Langmuir probe in Tore Supra; up-down asymmetry of density fluctuations; Halo currents in a circular tokamak; real time measurement of the position, density, profile and current profile at Tore Supra; poloidal rotation measurement by reflectometry; interpretation of q-profile dependence of the LH power deposition profile during LHCD experiments; ICFR plasma production and optimization; improved core electron confinement; measurement of hard X-ray emission profile; modelling of shear effects on thermal and particles transport; ion turbulence; current drive generation based on autoresonance and intermittent trapping mechanisms. (A.L.B.)

  19. Kinetics and immunocytochemical dyeing of monoclonal 99mTc-labelled anti-CEA-antibodies against granulocytes after intravenous administration

    International Nuclear Information System (INIS)

    Until now the clinical identification of the affinity of monoclonal 99mTc-anti-CEA antibodies (MAK BW 250/183) on granulocytes was made with tumor cells carrying the same epitope on NCA-95 and human granulocytes in vitro. As this antibody only binds human granulocytes in vitro. As this antibody only binds human granulocytes, animal experiments are impossible. 3 patients had their blood withdrawn within 6 h after injection, another patient had his left hip-joint biopsied after 24 h, the samples undergoing subsequent immunocytochemical dyeing. Dyeing of granulocytes all over the smears was evident whereas lymphocytes, monocytes and erythrocytes did not show any reaction. After 6 h there seemed to be a large difference between a relatively high quantity of 86% unlabelled 99mTc-MAb and 75% of immunocytochemically stainable granulocytes in the blood through an excess of binding epitopes. Six h after injection 27% of the activity were, on average, detectable in whole blood. At this time the activity in blood was reduced to an extent that scintigraphic imaging was feasible. (orig.)

  20. Review of nuclear data improvement needs for nuclear radiation measurement techniques used at the CEA experimental reactor facilities

    Directory of Open Access Journals (Sweden)

    Destouches Christophe

    2016-01-01

    Full Text Available The constant improvement of the neutron and gamma calculation codes used in experimental nuclear reactors goes hand in hand with that of the associated nuclear data libraries. The validation of these calculation schemes always requires the confrontation with integral experiments performed in experimental reactors to be completed. Nuclear data of interest, straight as cross sections, or elaborated ones such as reactivity, are always derived from a reaction rate measurement which is the only measurable parameter in a nuclear sensor. So, in order to derive physical parameters from the electric signal of the sensor, one needs specific nuclear data libraries. This paper presents successively the main features of the measurement techniques used in the CEA experimental reactor facilities for the on-line and offline neutron/gamma flux characterizations: reactor dosimetry, neutron flux measurements with miniature fission chambers and Self Power Neutron Detector (SPND and gamma flux measurements with chamber ionization and TLD. For each technique, the nuclear data necessary for their interpretation will be presented, the main identified needs for improvement identified and an analysis of their impact on the quality of the measurement. Finally, a synthesis of the study will be done.

  1. Development and manufacturing of a Nb$_{3}$Sn quadrupole magnet Model at CEA/Saclay for TESLA Interaction Region

    CERN Document Server

    Durante, Maria; Fratini, M; Leboeuf, D; Segreti, M; Védrine, Pierre; 10.1109/TASC.2004.829129

    2004-01-01

    One possible application of Nb/sub 3/Sn, whose superconducting properties far exceed those of NbTi, is the fabrication of short and powerful quadrupole magnets for the interaction regions of large particle accelerators. In some projects, as in the future linear collider TESLA, the quadrupole magnets are inside the detector solenoid and must operate in its background field. This situation gives singular Lorentz force distribution in the ends of the magnet. To learn about Nb/sub 3/Sn technology, evaluate fabrication techniques and test the interaction with a solenoidal field, DAPNIA /SACM at CEA/Saclay has started the manufacturing of a 1-m-long, 56- mm-single-aperture quadrupole magnet model. The model relies on the same coil geometry as the LHC arc quadrupole magnets, but has no iron yoke. It will produce a nominal field gradient of 211 T/m at 11,870 A. The coils are wound from Rutherford-type cables insulated with glass fiber tape, before being heat-treated and vacuum-impregnated with epoxy resin. Laminated,...

  2. Principais doenças de Anonáceas no Brasil: descrição e controle

    Directory of Open Access Journals (Sweden)

    Nilton Tadeu Vilela Junqueira

    2014-01-01

    Full Text Available Várias doenças podem afetar folhas, caules, flores e frutos de gravioleira, pinheira e atemoia em diferentes estádios de seus desenvolvimentos. Geralmente, as doenças mais importantes são causadas por fungos durante o florescimento e a frutificação. Também podem ocorrer murchas ou podridões de raízes, causadas por nematoides e patógenos do solo. A antracnose (Colletotrichum gloeosporioides, murcha ou podridões de raízes (Rhizoctonia solani, Cylindrocladium clavatum, Phytophthora sp., Pythium sp., Phytophthora nicotianae var. parasitica, cancros (Albonectria rigidiuscula e podridão de frutos (Botryodiplodia theobromae, sin. Lasiodiplodia theobromae são as mais importantes. Por outro lado, a podridão-parda-do-fruto (Rhizopus stolonifer provoca perdas expressivas na produção de graviola. A seguir, são descritas as principais doenças que afetam estas espécies de anonáceas, seus agentes causais e as medidas de controle.

  3. Caracterização físico-química de algumas tuberosas amiláceas

    Directory of Open Access Journals (Sweden)

    Leonel Magali

    2002-01-01

    Full Text Available As principais fontes de amido comercial no mundo são o milho, a batata e a mandioca. Entretanto, nos últimos anos vem crescendo o interesse em amidos naturais que possam ser utilizados pela indústria alimentícia. Assim, este trabalho teve por objetivo caracterizar, quanto à composição físico-química, açafrão, ahipa, araruta, batata-doce, biri, inhame e mandioquinha-salsa, tuberosas amiláceas potencialmente passíveis de introdução como matérias-primas de interesse comercial. Amostras das tuberosas foram analisadas quanto ao teor de umidade, cinzas, proteína, matéria graxa, açúcares redutores e totais, fibras e amido. Os resultados obtidos mostraram que das tuberosas analisadas as que apresentaram maior teor de amido foram a araruta (Maranta arundinacea, o inhame (Dioscorea sp e o biri (Canna edulis, sendo que o inhame e o biri apresentaram também o maior rendimento potencial em toneladas de amido/hectare.

  4. Development of instant kits 99Tcm-labelling of anti-CEA antibody and hIgG for scintigraphy

    International Nuclear Information System (INIS)

    99Tcm-labelled monoclonal antibodies (MAbs) and human immunoglobulins (hIgG) have recently emerged as a new class of site specific radiopharmaceuticals. The role of 99Tcm-labelled MAbs particularly anti-CEA IgG in tumour imaging has essentially established for early revealing of occult lesions in patients. Superiority of the method over X ray CT has been addressed for its capability in differentiating post-operation fibrosis from viable tumour. At present data, instant kits for preparation of this particular class of radiopharmaceuticals can be obtained from commercial sources but unfortunately at high prices. This prohibits the use of these promising diagnostic agents in developing country like Thailand. Under the assistance from IAEA through a research coordinating program, we worked on the 99Tcm-radiochemistry in immunoglobulin labelling to establish the knowledge and acquire the know how in the development of in-house instant kits at low cost to serve the local nuclear medicine clinics in diagnosis of infectious and neoplastic diseases

  5. Significance of CEA, CA15-3 and biochemical markers of bone turnover in the diagnosis of bone metastasis from breast cancer

    International Nuclear Information System (INIS)

    Objective: To evaluate the significance of tumor markers CEA and CA15-3, and biochemical markers of bone turnover (total procollagen type Ⅰ amino-terminal propeptide (TP Ⅰ NP), β-isomerized carboxyterminal propeptide (β-CTx), ALP and PTH) in the diagnosis of bone metastasis from breast cancer. Methods: A total of 78 patients (all females) with mean age (56.72 ± 10.76) years, who were diagnosed with breast cancer, were included in this study. The patients were divided into two groups based on radionuclide bone imaging: with bone metastasis (n=32) and without bone metastasis (n=46). The serum concentrations of CEA, CA15-3, TP Ⅰ NP, β-CTx, PTH, ALP were measured. Gleason scores were evaluated. The diagnostic value was evaluated by ROC curve.The two groups were compared using two-sample t test. The correlations between bone metastasis and tumor markers, bone metastasis and biochemical markers of bone turnover were analyzed with Pearson correlation and logistic analysis. Results: The serum levels of CEA, CA15-3, TP Ⅰ NP, β-CTx, PTH and ALP were significantly higher in the group with bone metastasis than those in the group without bone metastasis (t: 4.16-7.56, all P<0.05). For the diagnosis of bone metastasis from breast cancer, the AUC of CEA, CA15-3, TP Ⅰ NP, [β-CTx, PTH and ALP was 0.815, 0.887, 0.869, 0.852, 0.844, 0.731, respectively. Using the cut-off values of 4.18 μg/L for CEA, 0.04 U/L for CA15-3, 49.70 μg/L for TP Ⅰ NP, 0.47 pg/L for β-CTx,54.90 ng/L for PTH and 49.90 U/L for ALP, the sensitivities were 56.3% (18/32), 75.0% (24/32), 78.1% (25/32), 81.3% (26/32), 78.1% (25/32), 68.8% (22/32) and the specificities were 80.4% (37/46), 84.8% (39/46), 76.1% (35/46), 78.3% (36/46), 69.6% (32/46), 58.7% (27/46), respectively. CEA, CA15-3, TP Ⅰ NP, β-CTx, PTH, ALP and Gleason score were positively correlated with the presence of bone metastasis (r: 0.267-0.636, all P<0.05). CEA, CA15-3, TP Ⅰ NP, β-CTx, PTH and Gleason score were independent

  6. Presentation of the CEA's crisis national organization: coordination centre in case of crisis, crisis technical teams, intervention means, and so on

    International Nuclear Information System (INIS)

    After having briefly recalled the existence of a legal framework for crisis management organisation, this report briefly describes how the CEA plans the crisis management. This management is based on the definition of critical scenarios, on the building up of a crisis management team, and on the elaboration of crisis management operational documents. It evokes the alert organisation and the triggering of crisis management. Then, it describes the CEA's national crisis organisation with its main crisis management structures, the role and the operation of the Crisis Coordination Centre (CCC, the decision body), the role and operation of the Central Crisis Technical Teams (ETC-C, Equipes Techniques de Crise Centrales), the role of field interveners (various rescue, protection, health care and technical teams) and of other additional intervention actors. It evokes the objectives of the various exercises which are organised every year at the internal, national or international level

  7. The CEA Cadarache site. Additional safety assessment with respect to the accident which occurred in the Fukushima-Daiichi nuclear power station

    International Nuclear Information System (INIS)

    After a presentation of some characteristics of the CEA Cadarache site (internal and external industrial environment, crisis management organization at the CEA level and at the local level), this document reports the identification of structures and equipment concerned by crisis management (site support functions, critical structures and equipment concerned by additional safety assessments). Then, it addresses the different risks: earthquake (sizing of critical structures and equipment, margin assessment), flooding (possible origins, alarm measures), other extreme natural events (extreme meteorological conditions, extreme earthquake with induced flooding, forest fire), and loss of electric supplies and of cooling systems. The last parts address the organization of accident management in situation typically related to additional safety management), and subcontracting conditions and practices

  8. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer

    DEFF Research Database (Denmark)

    Kristiansen, Søren; Jørgensen, Lars Mønster; Høgh Hansen, Morten;

    2015-01-01

    The serological protein tumor markers CA 15-3, CEA, and TPA are frequently used to monitor tumor burden among metastatic breast cancer patients. Breast cancer is associated with global DNA hypomethylation and hypermethylation of some promoter regions. No monitoring study has yet investigated the...... interrelationship between protein tumor markers, the global DNA hypomethylation, and hypermethylated genes in serum from patients with advanced disease. Twenty-nine patients with histologically proven advanced breast cancer received first-line chemotherapy with epirubicin. Samples were collected prior to each...... treatment and prospectively analyzed for CA 15-3, CEA, and TPA. The same samples were retrospectively analyzed for the concentration of hypermethylated RASSF1A and for global DNA hypomethylation using LINE-1. Among patients with elevated concentrations of the protein markers, concordance could be observed...

  9. Radioimmunoimaging of non-small cell lung cancer with [sup 111]In- and [sup 99m]Tc-labeled monoclonal anti-CEA antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Kairemo, K.J.A. (Dept. of Clinical Chemistry, Helsinki Univ. Central Hospital (Finland)); Aronen, H.J. (Dept. of Radiology, Helsinki Univ. Central Hospital (Finland)); Liewendahl, K. (Dept. of Clinical Chemistry, Helsinki Univ. Central Hospital (Finland)); Paavonen, T. (Dept. of Pathology, Helsinki Univ. Central Hospital (Finland)); Heikkonen, J.J. (Dept. of Radiotherapy and Oncology, Helsinki Univ. Central Hospital (Finland)); Virkkunen, P. (Dept. of Radiotherapy and Oncology, Helsinki Univ. Central Hospital (Finland)); Maeki-Hokkonen, H. (Dept. of Radiotherapy and Oncology, Helsinki Univ. Central Hospital (Finland)); Karonen, S.L. (Dept. of Clinical Chemistry, Helsinki Univ. Central Hospital (Finland)); Brownell, A.L. (Dept. of Clinical Chemistry, Helsinki Univ. Central Hospital (Finland)); Maentylae, M.J. (Dept. of Radiotherapy and Oncology, Helsinki Univ. Central Hospital (Finland))

    1993-01-01

    Radiolabeled monoclonal anti-CEA antibodies were used for radioimmunolocalization (RIL) of non-small cell lung cancer; in 30 patients with [sup 111]In labeled anti CEA F(ab')[sub 2] fragment (BW 431/31) and in 16 with [sup 99m]Tc-labeled intact MoAb (BW 431/26). RIL results were compared with those of other imaging modalities. Paraffin sections from some patients were also studied immunohistochemically using anti-CEA antibody. Patients with [sup 111]In labeled MoAB were imaged twice 1-4 days after injection and for image enhancement pulmonary and liver/spleen subtraction were performed. Twenty-seven of 28 primary tumors were positive and metastases were detected in all patients. The total number of lesions was 78 of which 61 (78%) could be detected by RIL. For verification CT was applied to the study of 46 lesions detected by RIL. We found 6 unknown lesions subsequently verified histologically. Using subtraction techniques we detected 9 lesions in 4 patients, later verified as plumonary metastases, not detected in unprocessed images. Pleural, mediastinal and pericardial lesions were also better delineated in subtracted images than in unprocessed images. Imaging of non-small cell lung cancer with [sup 99m]Tc-labeled MoAB was performed twice 4-24 h after injection. RIL results were compared with other imaging methods; CT US, conventional radiography, and immunohistochemistry. Twelve out of 16 patients with suspected or known lung cancer had positive immunoscintigrams; 19 of 25 lesions could be detected by RIL. There were 5 false positive and 2 true negative findings. Immunoperoxidase (IP) stainings of paraffin sections of the tumours from 7 patients were performed using two different anti-CEA antibodies; BW 431/26 and ZCEA[sub 1]. None of the seven tumors examined by immunohistochemistry were negative when stained by BW 431/26, which was the antibody used for immunoscintigraphy. (orig.).

  10. Receiver operating characteristic (ROC) curve analysis of the tumour markers CEA, CA 50 and CA 242 in pancreatic cancer; results from a prospective study.

    OpenAIRE

    Pasanen, P. A.; Eskelinen, M.; Partanen, K.; Pikkarainen, P; Penttilä, I.; Alhava, E

    1993-01-01

    The serum values of the tumour markers carcinoembryonic antigen (CEA), cancer-associated carboanhydrate antigens CA 50 and CA 242 were evaluated in 193 patients with hepatopancreato-biliary diseases by receiver operating characteristic (ROC) curve analysis in order to compare their diagnostic accuracy in pancreatic cancer (n = 26), and to define optimal cut-off levels for the serum values of these tumour markers in the diagnosis of pancreatic cancer. The ROC analysis showed that all marker te...

  11. Disolución y génesis del karst en rocas carbonáticas y rocas silíceas : un estudio comparado.

    OpenAIRE

    GALAN, Carlos

    1991-01-01

    Se describen los mecanismos físicos y químicos que   intervienen en la formación del karst en rocas silíceas y   carbonáticas. Los modelados resultantes son comparados. Se   analizan los factores hidrogeológicos, se cuantifica el trabajo   de excavación y se discute la edad de las formas.

  12. Radioimmunoscintigraphy using 99mTc-anti-CEA F(ab's)2 fragment in rectal cancer and a pilot study for radioimmunoguided surgery

    International Nuclear Information System (INIS)

    This prospective study was performed to evaluate the usefulness of preoperative radioimmunoscintigraphy and intraoperative scintimetric examination (radioimmunoguided surger: RIGS) using99mTc-anti-CEA F(ab')2 fragment. Nineteen patients with rectal cancer underwent preoperative whole body planar scintigraphy at 4 hours after injection of 99mTc-anti-CEA F(ab')2 fragment and SPECT imaging at 18 hours. Surgical operation was performed at 24 hours after injection. During laparotomy, radioactivities from intraabdominal viscera were measured by gamma probe. The radioactivities from excised tumor and lymph nodes were also measured and compared with pathology. All nineteen patients were confirmed to have adenocarcinomas in the rectum. Twenty-seven of 97 excised lymph node groups had metastasis and 2 patients had liver metastasis in pathology. Preoperative radioimmunoscintigraphy detected primary tumors in 11 patients (sensitivity 55%) and it could not detect any lymph nodes or liver metastasis. All patients showed high radioactivity in the kidneys, liver, spleen, and major vessels in intraoperative measurement by gamma probe, and tumor activity was not discriminated from background activity. However, radioactivity from excised tumor was higher than normal rectum (T/B ratio; 3,47±2.25). When excised lymph node activity/background activity ratio >1.5 was considered as positive criteria of metastasis, sensitivity, specificity, positive and negative predictive values were 78.6%, 73.9%, 55.0% and 89.5%, respectively. Radioimmunoscintigraphy using 99mTc-anti-CEA F(ab')2 has no additional value for preoperative staging and use of early RIGS using 99mTc-anti-CEA F(ab')2 is inappropriate. For early RIGS using 99mTc labeled antibodies in rectal cancer patients, further development of more specific antibodies and methods to reduce background activity are needed.=20

  13. Anti-CEA monoclonal antibody: technetium-99m labeling and the validation process of a scintigraphic animal model with a non-cellular antigenic implant.

    Science.gov (United States)

    Sapienza, Marcelo Tatit; Marques, Fabio Luiz Navarro; Okamoto, Miriam Roseli Yoshie; Hironaka, Fausto Haruki; Buchpiguel, Carlos Alberto

    2002-07-01

    Animal models are currently used to verify the biodistribution of different radiopharmaceuticals before its clinical application in Nuclear Medicine; however, there may be some limitations. The utilization of labelled anti-tumor monoclonal antibodies (MoAb) in experimental models often requires implant of human antigens (usually a cellular implant), which cannot be achieved in immunocompetent animals. Our purpose was to label an anti-CEA MoAb with technetium-99m (99Tc) and to validate a simplified animal model using a noncellular antigenic implant. MoAb was directly labelled with 99mTc, after reduction with 2-mercaptoethanol. Labeling efficiency was checked by ascending chromatography and immunoreactive fraction was measured in plastic wells sensitized with the antigen. Radiopharmaceutical biodistribution was evaluated by dissection and scintigraphy in 5 mice groups; following the subcutaneous administration of Al(OH)3, CEA adsorbed Al(OH)2 and a control group evaluation. Labeling efficiency was 94+/-3%, which showed to be stable for 24 hr, with immunoreactive fraction above 50%. Invasive biodistribution evaluation showed prolonged blood retention, hepatic and renal uptake. A significant increase in uptake was observed in scintigraphic studies of animals with CEA-adsorbed Al(OH)3 implants compared with the other groups (p<0.05). The non-cellular antigenic implant model simplifies the pre-clinical evaluation of labelled MoAb. PMID:12146705

  14. Combination of IGF-1 with CEA, CYFRA21-1, NSE for the diagnosis and prediction of treatment response in lung cancer

    International Nuclear Information System (INIS)

    Objective: To evaluate four tumor markers of insulin-like growth factor 1((IGF-1), CEA, cytokeratin fragment antigen 21-1 (CYFRA21-1), neuron-specific enolase (NSE) for the diagnosis and prediction of treatment response in human lung cancer. Methods: Serum samples were taken from three groups: 91 patients with lung cancer, 30 healthy adults and 15 patients with benign pulmonary diseases. Serum IGF-1 was assayed by radioimmunoassay and CEA, CYFRA21-1, and NSE by electrochemiluminescence immunoassay. The differences among the three groups were determined by Kruskal-Wallis one-way analysis of variance (ANOVA) and with Mann-Whitney rank-sum test. Diagnostic efficacy was evaluated by ROC curves. Results: The four serum tumor marker levels were significantly higher in lung cancer group, as compared with the benign and the healthy (IGF-1: χ2=26.95, P2=49.11, P2=40.63, P2=14.76; P2=5.99, P=0.014; CYFRA21-1: χ2=4.99, P=0.025) in cancer group. Conclusions: Serum IGF-1, CEA, CYFRA21-1 and NSE are all valuable for lung cancer diagnosis and the combination of those parameters can enhance the diagnostic efficiency. Serum IGF-1 and CYFRA21-1 may also be useful for evaluating the treatment response in lung cancer. (authors)

  15. Antibody-guided irradiation of hepatic metastases using intrahepatically administered radiolabelled anti-CEA antibodies with simultaneous and reversible hepatic blood flow stasis using biodegradable starch microspheres.

    Science.gov (United States)

    Epenetos, A A; Courtenay-Luck, N; Dhokia, B; Snook, D; Hooker, G; Lavender, J P; Hemmingway, A; Carr, D; Paraharalambous, M; Bosslet, K

    1987-12-01

    Two monoclonal antibodies to carcinoembryonic antigen (CEA) were radiolabelled with 131I and used for the treatment of hepatic metastases in a patient who had a primary colonic carcinoma. Approximately 100 mCi of 131I-labelled antibody were administered via the hepatic artery on two occasions. On the second occasion, radiolabelled antibody was given concurrently with biodegradable starch microspheres in an attempt to enhance tumour uptake of antibody by achieving temporary stasis or delay of hepatic blood flow. The procedure was carried out uneventfully. There was clinical improvement and a fall in circulating CEA levels after each course of treatment. Furthermore, after the second course of therapy the clinical improvement was sustained for a longer period (more than 3 months) and there was evidence of diminution in the size of some of the liver metastases. Regional administration of 131I-labelled anti-CEA antibody concurrently with biodegradable starch microspheres appears to be a promising new method for the treatment of hepatic metastases from colonic carcinoma. PMID:3449789

  16. From moon stones to simulation - More than 40 years of experiments on the 7 MV tandem accelerator at Cea/Dam Ile de France; Des pierres de lune a la simulation - Plus de 40 ans d'experiences aupres de l'accelerateur Van de Graaff tandem 7 MV CEA/DAM Ile de France

    Energy Technology Data Exchange (ETDEWEB)

    Bauge, E.; Bersillon, O.; Couillaud, Ch.; Daugas, J.M.; Flament, J.L.; Frehaut, J.; Haouat, G.; Joly, S.; Laborie, J.M.; Ledoux, X.; Marmouget, J.G.; Patin, Y.; Poncy, J.L.; Sigaud, J.; Varignon, C

    2009-07-01

    Following the decommissioning of the 7 MV tandem accelerator of CEA/DAM by the end of 2007, the present report relates the history of the accelerator from its beginning in the sixties and then the nuclear physics studies on fission, (x,xn) reactions, elastic and inelastic scattering, etc and other studies in microelectronics, biology, etc) performed with that installation. (authors)

  17. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

    Directory of Open Access Journals (Sweden)

    Isabella Coimbra Wagner

    2007-04-01

    Full Text Available OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA, fragmento da citoqueratina 19 (CYFRA21-1 e antígeno glicosídico associado a tumor 15-3 (CA 15-3 em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi realizada por eletroquimioluminescência. A sensibilidade foi determinada sob a condição de que a especificidade fosse > 90%. RESULTADOS: Foram diagnosticados 36 casos malignos (42,4%, 30 benignos (35,3%; em 19 pacientes (22,3%, o diagnóstico foi inconclusivo. Nos casos malignos, os valores de CEA e CYFRA21-1 foram maiores no líquido pleural do que no sangue, fato não observado para o CA 15-3. Nos casos benignos, os valores do CYFRA21-1 foram maiores no líquido pleural do que no soro, enquanto que para o CEA e o CA 15-3, ocorreu o oposto. Todos os marcadores apresentaram diferença significativa entre os casos malignos e benignos, em líquido pleural e soro. Foi encontrada sensibilidade para CEA, CYFRA21-1 e CA 15-3 no líquido pleural de 69,4%, 69,4% e 66,7%, respectivamente e quando associados, foi 80,6%. No soro, a sensibilidade foi 57,1, 71,4 e 48,6% para CEA, CYFRA21-1 e CA 15-3, respectivamente, e quando associados, foi 77%. CONCLUSÃO: Os resultados sugerem que a utilização desses marcadores pode ser útil na diferenciação entre derrames pleurais malignos e benignos.OBJECTIVE: To determine the levels of the tumor markers carcinoembryonic antigen (CEA, cytokeratin 19 fragment (CYFRA21-1 and carbohydrate antigen 15-3 (CA 15-3 in the blood and pleural fluid of patients with benign or malignant pleural effusion, evaluating the sensitivity of each marker in these fluids. METHODS: We prospectively evaluated 85 patients with pleural effusion. The

  18. Rooting of herbaceous minicuttings of passion fruit/ Enraizamento de miniestacas herbáceas de maracujazeiro amarelo

    Directory of Open Access Journals (Sweden)

    Rudival Faquim

    2007-08-01

    Full Text Available The objective of this work was to evaluate the effect of the basal cut, leaf presence and the treament with a root suspension in the rooting of herbaceous minicuttings of yellow passion fruit. The experiment was realized in a greenhouse using minicuttings with 8 cm of lenght and two nodes, collected from yellow passion fruit seedlings. The longitudinal basal cut in the minicuttings was done until the basal node. The leaves were removed or a half of a single leaf was maintained in the apical node. The minicuttings were treated with a root suspension in water in three concentrations (0, 100 e 200 g L-1. After 58 days, the rooting percentage, the number of roots and the root dry matter produced per minicutting were determined. The entirely randomized experimental design was used in a factorial esqueme (2 x 2 x 3 with three replications. The propagation of the yellow passion fruit by herbaceous minicuttings was viable and the presence of the half of a single leaf in the apical node give a higher production of number and dry matter of roots. The basal cut was only a little favourable to the production of roots and the treatment with a root suspension did not present a benefit to the plant propagation.Este trabalho objetivou avaliar a influência do corte basal, da presença da folha e do tratamento com suspensão de raízes no enraizamento de miniestacas herbáceas de maracujazeiro amarelo. O experimento foi conduzido em casa de vegetação com miniestacas de 8 cm de comprimento e dois nós, obtidas de mudas de maracujazeiro. O corte longitudinal na base das estacas foi feito até o nó basal. Foram retiradas as folhas ou mantida a metade da folha do nó apical. As miniestacas foram tratadas com suspensão de raízes mais água nas concentrações de 0, 100 e 200 g L-1. Após 58 dias, determinou-se a porcentagem de estacas enraizadas, o número de raízes emitidas e a massa seca de raízes por estaca. O delineamento experimental utilizado foi o

  19. Construction of predictive models for radionuclide sorption applied to radioactive waste deep storage: an overview of the CEA research program

    International Nuclear Information System (INIS)

    Full text of publication follows: Deep geological storage is studied in France as one of the three potential options for managing long lived nuclear waste in the framework of the 1991 Law. One of the key topics of research deals with the behaviour of radionuclides (RN) in the geological environment, focusing in particular on the retention at the solid/water interfaces (in the engineered barriers or within the host rock), the diffusion process within the rock as well as the coupling between chemistry and transport processes. The final aim is to develop validated and reliable long-term predictive migration models. These researches are mainly coping with Callovo-Oxfordian argilites and near field materials such as cement and bentonite. Research are dealing both with the near-field environment - which is characterised by its evolution with time in terms of temperature, Eh balance, water composition - and the far-field environment, the chemistry of which is assumed to be roughly constant. Modelling the global RN migration in geological disposal requires having models which are intrinsically able to account for the evolution of the physical and chemical conditions of the environment. From the standpoint of performance assessment it is then necessary to acquire thermodynamic descriptions of the retention processes in order to perform calculations of the reactive transport of radionuclides In a first approach, CEA is developing for more than 15 years experiments and modelling to derive reliable predictive models for the RN migration in the geological disposal. For this purpose, a specific approach entitled the Ion-Exchangers Theory IXT was developed. It allows first to characterise the intrinsic retention properties of the pure minerals, i.e. to get evidence about the mono or multi-site character of the surface, to quantify the site(s) concentration(s) and to study the relative affinity of major solutes generally present in natural waters. This work provided a broad data

  20. Artrite da gota tofácea crônica mimetizando artrite reumatoide Chronic tophaceous gout mimicking rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Juliana F. Sarmento

    2009-12-01

    Full Text Available A gota é um distúrbio no metabolismo das purinas, usualmente associado à ocorrência de crises recorrentes de artrite nas articulações dos membros inferiores em homens entre 40-50 anos, e com o desenvolvimento de tofos subcutâneos nos pacientes com doença de longa evolução. Casos de pacientes com artrite gotosa crônica que mimetizam quadros de artrite reumatoide e vice-versa são raros. Descrevemos o caso de um paciente de 56 anos, com quadro de artrite poliarticular, simétrica e deformante, comprometendo principalmente as articulações de mãos e punhos, com nódulos subcutâneos difusos pelo corpo, alterações radiográficas atípicas e urolitíase, que, após avaliação clínica e dos exames complementares, recebeu diagnóstico de gota tofácea crônica mutilante mimetizando artrite reumatoide.Gout is a disorder of purine metabolism, usually associated with recurrent bouts of arthritis in the joints of the lower limbs, affecting men 40 to 50 years of age, which leads to the development of subcutaneous tophi in patients with long-lasting disease. Cases of patients with chronic gouty arthritis mimicking rheumatoid arthritis, and vice-versa, are rare. This report describes the case of a 56-year old male with symmetric, deforming, and polyarticular arthritis affecting, specially, the joints of the hands and wrists, with diffuse subcutaneous nodules throughout his body, atypical radiographic findings, and urolithiasis. Following clinical evaluation and additional tests, this patient received a diagnosis of chronic tophaceous gout mimicking mutilating rheumatoid arthritis.

  1. CEA studies on advanced nuclear fuel claddings for enhanced accident tolerant LWRs fuel (LOCA and beyond LOCA conditions)

    International Nuclear Information System (INIS)

    This paper gives an overview of CEA studies on advanced nuclear fuel claddings for enhanced Accident Tolerant LWR Fuel in collaboration with industrial partners AREVA and EDF. Two potential solutions were investigated: chromium coated zirconium based claddings and SiC/SiC composite claddings with a metallic liner. Concerning the first solution, the optimization of chromium coatings on Zircaloy-4 substrate has been performed. Thus, it has been demonstrated that, due in particular to their slower oxidation rate, a significant additional 'grace period( can be obtained on high temperature oxidized coated claddings in comparison to the conventional uncoated ones, regarding their residual PQ (Post-Quench) ductility and their ability to survive to the final water quenching in LOCA and, to some extent, beyond LOCA conditions. Concerning the second solution, the innovative 'sandwich' SiC/SiC cladding concept is introduced. Initially designed for the next generation of nuclear reactors, it can be adapted to obtain high safety performance for LWRs in LOCA conditions. The key findings of this work highlight the low sensitivity of SiC/SiC composites under the explored steam oxidation conditions. No signification degradation of the mechanical properties of CVI-HNI SiC/SiC specimen is particularly acknowledged for relatively long duration (beyond 100 h at 1200 Celsius degrees). Despite these very positive preliminary results, significant studies and developments are still necessary to close the technology gap. Qualification for nuclear application requires substantial irradiation testing, additional characterization and the definition of design rules applicable to such a structure. The use of a SiC-based fuel cladding shows promise for the highest temperature accident conditions but remains a long term perspective

  2. CEA (Carcinoembryonic Antigen) Test

    Science.gov (United States)

    ... may also be used as a marker for medullary thyroid cancer and cancers of the rectum, lung , ... ulcerative colitis , rectal polyps , emphysema , and benign breast disease. ^ Back to top Proudly sponsored by ... Learn more ...

  3. CEA blood test

    Science.gov (United States)

    ... return of colon and other cancers such as medullary thyroid cancer and cancers of the rectum, lung, ... or gallbladder inflammation ( cholecystitis ) Heavy smoking Inflammatory bowel diseases (such as ulcerative colitis or diverticulitis ) Lung infection ...

  4. Developments toward the use of tungsten as armour material in plasma facing components promoted by Euratom-CEA Association

    International Nuclear Information System (INIS)

    Tungsten is increasingly considered as a prime candidate armour material facing the plasma in fusion experiments (ASDEX, JET, ITER). This material is, however, a challenge for the engineers due to its brittleness at room temperature. Its bonding to structural or cooled substrates is a critical issue. The Euratom-CEA Association promotes the development of evolutionary techniques aiming to produce high performance assemblies between tungsten and various substrates. These are 1) functionally graded tungsten to copper, 2) direct electron beam welding of tungsten to Mo-alloy TZM and 3) the characterisation of tungsten coatings deposited on carbon fibre composite by high energy deposition processes. 1) A functionally graded material eliminates the singular point which weakens the heterogeneous assembly, reducing the stresses and allowing a better behaviour. The sintering of submicronic W-Cu powders is investigated. The green shape is processed from W-CuO powder, which is reduced by a hydrogen flow. The compaction and sintering of layers of various compositions (10 to 30 % Cu) produces an assembly (density of ∼ 94%) with a good cohesion. However, the gradient is not effectively controlled, because of the migration of melt copper during the sintering. Future work aims to improve the process by using spark or microwave assisted sintering. 2) Electron beam welding of Mo-alloy TZM is investigated, to produce high temperature components required by radiation cooled PFCs. They require only mechanical properties and no vacuum sealing. The driving line is to use simple tungsten shapes to reduce the milling cost. In spite of low weldable properties of the refractory alloys, a good bonding up to a depth of 5 mm is obtained. Hardness measurements show that the melt area and the heat affected zone are harder than TZM, the weakest materials at 230 Hv. Quench tests in water from up to 2000oC are done without apparent crack formation. 3) Finally, characterisation techniques are

  5. Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Ali A Maawy

    Full Text Available Photoimmunotherapy (PIT of cancer utilizes tumor-specific monoclonal antibodies conjugated to a photosensitizer phthalocyanine dye IR700 which becomes cytotoxic upon irradiation with near infrared light. In this study, we aimed to evaluate the efficacy of PIT on human pancreatic cancer cells in vitro and in vivo in an orthotopic nude mouse model. The binding capacity of anti-CEA antibody to BxPC-3 human pancreatic cancer cells was determined by FACS analysis. An in vitro cytotoxicity assay was used to determine cell death following treatment with PIT. For in vivo determination of PIT efficacy, nude mice were orthotopically implanted with BxPC-3 pancreatic tumors expressing green fluorescent protein (GFP. After tumor engraftment, the mice were divided into two groups: (1 treatment with anti-CEA-IR700 + 690 nm laser and (2 treatment with 690 nm laser only. Anti-CEA-IR700 (100 μg was administered to group (1 via tail vein injection 24 hours prior to therapy. Tumors were then surgically exposed and treated with phototherapy at an intensity of 150 mW/cm2 for 30 minutes. Whole body imaging was done subsequently for 5 weeks using an OV-100 small animal imaging system. Anti-CEA-IR700 antibody bound to the BxPC3 cells to a high degree as shown by FACS analysis. Anti-CEA-IR700 caused extensive cancer cell killing after light activation compared to control cells in cytotoxicity assays. In the orthotopic models of pancreatic cancer, the anti-CEA-IR700 group had significantly smaller tumors than the control after 5 weeks (p<0.001. There was no significant difference in the body weights of mice in the anti-CEA-IR700 and control groups indicating that PIT was well tolerated by the mice.

  6. CEA Level, Radical Surgery, CD56 and CgA Expression Are Prognostic Factors for Patients With Locoregional Gastrin-Independent GNET

    Science.gov (United States)

    Li, Yuan; Bi, Xinyu; Zhao, Jianjun; Huang, Zhen; Zhou, Jianguo; Li, Zhiyu; Zhang, Yefan; Li, Muxing; Chen, Xiao; Hu, Xuhui; Chi, Yihebali; Zhao, Dongbing; Zhao, Hong; Cai, Jianqiang

    2016-01-01

    Abstract Gastrin-independent gastric neuroendocrine tumors (GNETs) are highly malignant. Radical resections and lymphadenectomy are considered to be the only possible curative treatment for these tumors. However, the prognosis of gastrin-independent GNETs is not well defined. In this study, we identified prognostic factors of locoregional gastrin-independent GNETs. All patients diagnosed with locoregional gastrin-independent GNETs between 2000 and 2014 were included in this retrospective study. Clinical characteristics, blood tests, pathological characteristics, treatments, and follow-up data of the patients were collected and analyzed. Of the 66 patients diagnosed with locoregional gastrin-independent GNETs, 57 (86.4%) received radical resections, 7 (10.6%) with palliative resection, 1 (1.5%) with gastrojejunostomy, and 1 (1.5%) with exploration surgeries. The median survival time for these patients was 19.0 months (interquartile range, 11.0–38.0). The 1-, 3-, and 5-year survival rates were 72%, 34%, and 28%, respectively. Multivariate analysis indicated that carcinoembryonic antigen (CEA) level (P = 0.04), radical resection (P = 0.04), and positive Cluster of Differentiation 56 (CD56) expression (P = 0.016) were significant prognostic factors on overall survival rate. Further univariate and multivariate analysis of 57 patients who received radical resections found that CgA expression (P = 0.35) and CEA level (P = 0.33) are independent prognostic factors. Gastrin-independent GNETs had poor prognosis. Serum CEA level, radical surgery, CD56 and CgA expression are markers to evaluate the survival of patients with locoregional gastrin-independent GNETs. PMID:27149478

  7. Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen.

    Directory of Open Access Journals (Sweden)

    Fritz Ihler

    Full Text Available BACKGROUND: A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor cells committed to the neuroendocrine lineage or by transcriptional activation of neuroendocrine genes. METHODOLOGY/PRINCIPAL FINDINGS: To address this question we analyzed CEA424-SV40 TAg-transgenic mice that develop spontaneous tumors in the antral stomach region. Immunohistology revealed expression of the neuroendocrine marker chromogranin A in tumor cells. By ELISA an 18-fold higher level of serotonin could be detected in the blood of tumor-bearing mice in comparison to nontransgenic littermates. Transcriptome analyses of antral tumors combined with gene set enrichment analysis showed significant enrichment of genes considered relevant for human neuroendocrine tumor biology. This neuroendocrine gene signature was also expressed in 424GC, a cell line derived from a CEA424-SV40 TAg tumor, indicating that the tumor cells exhibit a similar neuroendocrine phenotype also in vitro. Treatment of 424GC cells with SV40 TAg-specific siRNA downregulated expression of the neuroendocrine gene signature. CONCLUSIONS/SIGNIFICANCE: SV40 TAg thus appears to directly induce a neuroendocrine gene signature in gastric carcinomas of CEA424-SV40 TAg-transgenic mice. This might explain the high incidence of neuroendocrine tumors in other murine SV40 TAg tumor models. Since the oncogenic effect of SV40 TAg is caused by inactivation of the tumor suppressor proteins p53 and RB1 and loss of function of these proteins is commonly observed in human neuroendocrine tumors, a similar mechanism might cause neuroendocrine phenotypes in human tumors.

  8. Evaluation of the concrete shield compositions from the 2010 criticality accident alarm system benchmark experiments at the CEA Valduc SILENE facility

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dunn, Michael E [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wagner, John C [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McMahan, Kimberly L [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Authier, Nicolas [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Jacquet, Xavier [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Rousseau, Guillaume [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Wolff, Herve [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Savanier, Laurence [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Baclet, Nathalie [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Lee, Yi-kang [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Trama, Jean-Christophe [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Masse, Veronique [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Gagnier, Emmanuel [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Naury, Sylvie [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Blanc-Tranchant, Patrick [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Hunter, Richard [Babcock International Group (United Kingdom); Kim, Soon [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dulik, George Michael [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, Kevin H. [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2015-01-01

    In October 2010, a series of benchmark experiments were conducted at the French Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA) Valduc SILENE facility. These experiments were a joint effort between the United States Department of Energy Nuclear Criticality Safety Program and the CEA. The purpose of these experiments was to create three benchmarks for the verification and validation of radiation transport codes and evaluated nuclear data used in the analysis of criticality accident alarm systems. This series of experiments consisted of three single-pulsed experiments with the SILENE reactor. For the first experiment, the reactor was bare (unshielded), whereas in the second and third experiments, it was shielded by lead and polyethylene, respectively. The polyethylene shield of the third experiment had a cadmium liner on its internal and external surfaces, which vertically was located near the fuel region of SILENE. During each experiment, several neutron activation foils and thermoluminescent dosimeters (TLDs) were placed around the reactor. Nearly half of the foils and TLDs had additional high-density magnetite concrete, high-density barite concrete, standard concrete, and/or BoroBond shields. CEA Saclay provided all the concrete, and the US Y-12 National Security Complex provided the BoroBond. Measurement data from the experiments were published at the 2011 International Conference on Nuclear Criticality (ICNC 2011) and the 2013 Nuclear Criticality Safety Division (NCSD 2013) topical meeting. Preliminary computational results for the first experiment were presented in the ICNC 2011 paper, which showed poor agreement between the computational results and the measured values of the foils shielded by concrete. Recently the hydrogen content, boron content, and density of these concrete shields were further investigated within the constraints of the previously available data. New computational results for the first experiment are now available

  9. Vegetación espontánea preferida por hormigas cortadoras en plantaciones de Salicáceas en el Delta del Paraná

    OpenAIRE

    Perri, Daiana; Casaubón, Edgardo; Gorosito, Norma; Gurini, Laura Beatriz; Fernández, Patricia Carina

    2015-01-01

    La vegetación de crecimiento espontáneo, llamada “maleza” es considerada perjudicial para las plantaciones de sauce y álamo. Las hormigas cortadoras de hojas (Acromyrmex sp.) son una de las plagas más importantes en la producción de Salicáceas y son combatidas con insecticidas de síntesis que contaminan el ambiente. El objetivo de este trabajo fue comenzar a evaluar las plantas cortadas por las hormigas en el campo y realizar ensayos de preferencia con el fin de proponer especies como cultivo...

  10. Diagnostic value of Cyfra21-1, SCC and CEA for differentiation of early-stage NSCLC from benign lung disease

    OpenAIRE

    Chen, Feng; Wang, Xiu-Ying; Han, Xiao-Hong; Wang, Hai; Qi, Jun

    2015-01-01

    Non-small cell lung cancer (NSCLC), which account for the most of lung carcinoma, is sometimes difficult to differentiate from benign lung diseases presented with nodular shadow in imaging scan. There is a need to find another non-invasive way to diagnosis early-stage NSCLC. To examine the potential diagnostic value of SCC, CFYRA 21-1 and CEA for the differentiation of early-stage NCSCL from benign lung diseases, we analyzed serum levels of tumor markers in 278 patients, including 248 patient...

  11. Association of Neisseria gonorrhoeae Opa(CEA with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response.

    Directory of Open Access Journals (Sweden)

    Qigui Yu

    Full Text Available Infection with Neisseria gonorrhoeae (N. gonorrhoeae can trigger an intense local inflammatory response at the site of infection, yet there is little specific immune response or development of immune memory. Gonococcal surface epitopes are known to undergo antigenic variation; however, this is unlikely to explain the weak immune response to infection since individuals can be re-infected by the same serotype. Previous studies have demonstrated that the colony opacity-associated (Opa proteins on the N. gonorrhoeae surface can bind human carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1 on CD4⁺ T cells to suppress T cell activation and proliferation. Interesting in this regard, N. gonorrhoeae infection is associated with impaired HIV-1 (human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte (CTL responses and with transient increases in plasma viremia in HIV-1-infected patients, suggesting that N. gonorrhoeae may also subvert immune responses to co-pathogens. Since dendritic cells (DCs are professional antigen presenting cells (APCs that play a key role in the induction of an adaptive immune response, we investigated the effects of N. gonorrhoeae Opa proteins on human DC activation and function. While morphological changes reminiscent of DC maturation were evident upon N. gonorrhoeae infection, we observed a marked downregulation of DC maturation marker CD83 when the gonococci expressing CEACAM1-specific Opa(CEA, but not other Opa variants. Consistent with a gonococcal-induced defect in maturation, Opa(CEA binding to CEACAM1 reduced the DCs' capacity to stimulate an allogeneic T cell proliferative response. Moreover, Opa(CEA-expressing N. gonorrhoeae showed the potential to impair DC-dependent development of specific adaptive immunity, since infection with Opa(CEA-positive gonococci suppressed the ability of DCs to stimulate HIV-1-specific memory CTL responses. These results reveal a novel mechanism to explain

  12. Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response.

    Science.gov (United States)

    Yu, Qigui; Chow, Edith M C; McCaw, Shannon E; Hu, Ningjie; Byrd, Daniel; Amet, Tohti; Hu, Sishun; Ostrowski, Mario A; Gray-Owen, Scott D

    2013-01-01

    Infection with Neisseria gonorrhoeae (N. gonorrhoeae) can trigger an intense local inflammatory response at the site of infection, yet there is little specific immune response or development of immune memory. Gonococcal surface epitopes are known to undergo antigenic variation; however, this is unlikely to explain the weak immune response to infection since individuals can be re-infected by the same serotype. Previous studies have demonstrated that the colony opacity-associated (Opa) proteins on the N. gonorrhoeae surface can bind human carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) on CD4⁺ T cells to suppress T cell activation and proliferation. Interesting in this regard, N. gonorrhoeae infection is associated with impaired HIV-1 (human immunodeficiency virus type 1)-specific cytotoxic T-lymphocyte (CTL) responses and with transient increases in plasma viremia in HIV-1-infected patients, suggesting that N. gonorrhoeae may also subvert immune responses to co-pathogens. Since dendritic cells (DCs) are professional antigen presenting cells (APCs) that play a key role in the induction of an adaptive immune response, we investigated the effects of N. gonorrhoeae Opa proteins on human DC activation and function. While morphological changes reminiscent of DC maturation were evident upon N. gonorrhoeae infection, we observed a marked downregulation of DC maturation marker CD83 when the gonococci expressing CEACAM1-specific Opa(CEA), but not other Opa variants. Consistent with a gonococcal-induced defect in maturation, Opa(CEA) binding to CEACAM1 reduced the DCs' capacity to stimulate an allogeneic T cell proliferative response. Moreover, Opa(CEA)-expressing N. gonorrhoeae showed the potential to impair DC-dependent development of specific adaptive immunity, since infection with Opa(CEA)-positive gonococci suppressed the ability of DCs to stimulate HIV-1-specific memory CTL responses. These results reveal a novel mechanism to explain why

  13. Preoperative CYFRA 21-1 and CEA as Prognostic Factors in Patients with Stage I Non-Small Cell Lung Cancer

    OpenAIRE

    Blankenburg, Florian; Hatz, Rudolf; Nagel, Dorothea; Ankerst, Donna Pauler; Reinmiedl, Judith; Gruber, Christine; Seidel, Dietrich; Stieber, Petra

    2008-01-01

    Objective: To validate the prognostic value of preoperative levels of CYFRA 21-1, CEA and the corresponding tumor marker index (TMI) in patients with stage I non-small cell lung cancer (NSCLC). Methods: Two hundred forty stage I NSCLC patients (80 in pT1 and 160 in pT2; 100 squamous cell carcinomas, 91 adenocarcinomas, 32 large-cell carcinomas, 17 with other histologies; 171 males and 69 females) who had complete resection (R0) between 1986 and 2004 were included in the analysis. CYFRA 21-1 a...

  14. Flow modelling in fractured aquifers, development of multi-continua model (direct and inverse problems) and application to the CEA/Cadarache site

    International Nuclear Information System (INIS)

    This research thesis concerns the modelling of aquifer flows under the CEA/Cadarache site. The author reports the implementation of a numerical simulation tool adapted to large scale flows in fractured media, and its application to the Cadarache nuclear site. After a description of the site geological and hydrogeological characteristics, the author presents the conceptual model on which the modelling is based, presents the inverse model which allows a better definition of parameters, reports the validation of the inverse approach by means of synthetic and semi-synthetic cases. Then, he reports experiments and simulation of the Cadarache site

  15. Techniques and devices developed by the CEA for hot cell and in-situ examinations of PWR components and PWR fuel assembliess after irradiation

    International Nuclear Information System (INIS)

    Within the framework of the electro-nuclear development of the PWR system, the CEA has provided itself with facilities for developing techniques for analyzing assemblies, pins and fuels. These are examinations and tests on irradiated heads and assemblies with the aid of the Fuel Examination Module (FEM), of machining of assemblies and examinations in the Celimene hot laboratory or detailed examinations and analyses on fuel elements using eddy currents, the electronic microprobe and the Fisher ''permeascope'' which enables the outline of the oxide coat present on the cladding to be followed

  16. The key role of critical mock-up facilities for neutronic physics assessment of advanced reactors: an overview of Cea Cadarache tools

    International Nuclear Information System (INIS)

    The Experimental Physics section of CEA Cadarache operates three critical facilities devoted to neutronic studies of advanced reactors (EOLE, MINERVE and MASURCA) covering a large scope of interests. These include 100% MOX core in ABWR qualification, knowledge improvement of basic nuclear data for heavy nuclides for new options of the fuel cycle - especially the multi-recycling of plutonium - and accelerator-driven systems neutronic behaviour for transmutation studies. The paper describes these facilities, the scientific programmes associated and the progressive improvement of experimental techniques, the aim being to significantly reduce the uncertainties regarding the evaluation of the physical parameters. (authors)

  17. List of reports in the field of reactor safety research from BMFT, CEA, EPRI, JSTA and USNRC. Reported period: July 1 to December 31, 1993

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning single problems in the field of Reactor Safety Research. According to the cooperation of the Bundesministerium fuer Forschung und Technologie (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technologie Agency (ISTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these reports are available in the Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Program of the BMFT, reporting organization. (orig./HP)

  18. List of reports in the field of reactor safety research from BMFT, CEA, EPRI, JSTA and USNRC. Reported period: January 1 to June 30, 1994

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning single problems in the field of Reactor Safety Research. According to the cooperation of the Bundesministerium fuer Forschung und Technologie (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technologie Agency (ISTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these reports are available in the Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Program of the BMFT, reporting organization. (orig./HP)

  19. Serum tetranectin is an independent prognostic marker in colorectal cancer and weakly correlated with plasma suPAR, plasma PAI-1 and serum CEA

    DEFF Research Database (Denmark)

    Høgdall, Claus K; Christensen, Ib J; Stephens, Ross W;

    2002-01-01

    to have an independent prognostic value for survival (log TN: HR = 0.47, 95% CI: 0.29-0.76); log soluble uPAR: HR = 1.65, 95% CI: 1.18-2.31; log CEA: HR = 1.I1, 95% CI: 1.03-1.20). Based on the multivariate model, a patient with a combination of low levels of TN and PAI-1 and elevated levels of...... prognostic factor in patients with colorectal cancer. TN may be valuable as a prognostic variable in future studies evaluating new treatment strategies for colorectal cancer....

  20. Development of a kit lyophilized of Anti-CEA to be labeled with Tc-99m, radionuclide obtained by extraction with MEK, complemented with studies of stability

    International Nuclear Information System (INIS)

    The colorectal cancer places the sixth place in Peru, more than 350 persons are diagnosed annually with this illness, for that reason, the present work contributes with the development of a lyophilized kit of monoclonal antibody Anti-CEA to be labelled by the radionuclide Tc-99m, for the early diagnosis of tumours embryonic adenocarcinoma. For the lack of a generator of adsorption of 99Mo / 99mTc in the country, the Tc-99m is used instead of this, coming from a generator of extraction, that use the methylethylketone (MEK) like solvent. First, it was designed systematically 4 lyophilized formulations and through the determination of the radiochemical purity of 99mTc-Anti-CEA, the effect of the molar relation has been evaluated of the MoAb: 2-ME (1:1000 and 1:2000), the increasing of the reductor agent (3,50 to 5,95 μg SnF2) and the reduced protein (1,0 to 1,2 mg Anti-CEA). Second. On the base of the evaluation of the results of these 4 lyophilized formulations, 4 experimental lots have been prepared. The developed methodology initiates with the reduction of the protein for the direct method with 2-ME, the purification in column of PD10, then the addition of the SnF2 and MDP, finally the lyophilization. Lyophilized kit is labeled by Tc-99m by the direct method to obtain 99mTc-Anti-CEA and the radiochemical purity is determined by chromatography in ITLC-SG and HPLC, activity support and volume of Tc-99m, biological distribution in healthy mice, immunoreactivity is determined by chromatography of affinity, challenge with L-cysteine determined by chromatography in ITLC-SG. It complements itself with studies of stability in real-time for the lyophilized kit and for 99mTc-Anti-CEA. The results of the first part, its 1st; 2nd; 3rd and 4th lyophilized formulation had a radiochemical purity of 71, 92, 94 and 97 % respectively, to a pH of labelled between 7,0 to 7,5. The results of the second part, 4 experimental lots had in average of radiochemical purity more than 95 %, it

  1. Enxertia herbácea em Myrtaceae nativas do Rio Grande do Sul Herbaceans grafiting in native Myrtaceae on Rio Grande do Sul

    OpenAIRE

    Daiane Silva Lattuada; Paulo Vitor Dutra de Souza; Mateus Pereira Gonzatto

    2010-01-01

    O objetivo deste trabalho foi testar a viabilidade da técnica de enxertia herbácea em frutíferas nativas da família Myrtaceae. O experimento foi realizado em casa de vegetação do Departamento de Horticultura e Silvicultura/ UFRGS, em Porto Alegre. Duas espécies de Myrtaceae nativas foram usadas, tanto como porta-enxerto quanto como enxerto, Eugenia uniflora (Pitangueira) e E. involucrata (Cerejeira-do-rio-grande ou Cerejeira-do-mato), totalizando quatro combinações. O método de enxertia adota...

  2. Evaluación de la actividad repelente de aceites esenciales de plantas Piperáceas del departamento de Chocó, Colombia

    OpenAIRE

    BE Jaramillo-Colorado; E Duarte-Restrepo; Nayive Pino-Benítez

    2015-01-01

    El objetivo de este trabajo fu e determinar la composición química volátil del aceite esencial de varias especies de Piper áceas ( Piper dilatatum, Piper aduncum, Piper divaricatum, Piper sp, Piper sanctifelicis) y la actividad repelente de ellos contra el gorgojo de granos almacenados Tribolium castaneum Herbst. Los aceites esenciales se obtuvieron por hidrodestilación, la separación e identificación de los component es volátiles se realizó por cromatografía de gase...

  3. Tumor-specific accumulation of 125I-labeled mouse-human chimeric anti-CEA antibody in a xenografted human cancer model demonstrated by whole-body autoradiography and immunostaining

    International Nuclear Information System (INIS)

    Whole-body autoradiography (WBAR) was used to study the biodistribution of 125I-labeled mouse-human chimeric antibody (Ch F11-39) to carcinoembryonic antigen (CEA) in athymic nude mice bearing the CEA-producing MKN-45 human gastric carcinoma xenografts. Significantly high uptake of 125I-Ch F11-39 in the tumors obtained by tissue-counting technique was confirmed by WBAR of mice of 12, 24, 48, and 96 h postinjection of 125I-Ch F11-39. When compared with histochemical or immunohistochemical staining results of the tumor tissue sections, imaging profiles of 125I-Ch F11-39 obtained by WBARs were topographically correlated with histopathological findings of tissues and immunohistochemical localization of CEA in the tumor tissues, indicating that the accumulation of 125I-Ch F11-39 at the tumor site is based on its specificity for CEA. These results demonstrate that this chimeric antibody may serve as a potential useful diagnostic and/or therapeutic reagent for human CEA-producing cancers

  4. Elaboration of an alpha-numeric classification for file of matters of the documentation service of the CEA; Elaboration d'une classification alfha-numerique pour le fichier matieres du service de documentation du Commissariat a l'Energie Atomique

    Energy Technology Data Exchange (ETDEWEB)

    Braffort, P. [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

    1953-07-01

    We give the principles of a classification of matters to square basis, suiting the needs of the Service, of Documentation of the C.E.A. We present the detail of the categories in the order of the 'columns', likewise the big scientific subdivisions at the CEA. (authors) [French] On donne les principes d'une classification matieres a base carree, convenant aux besoins du Service de Documentation du C.E.A. On presente ensuite le detail des rubriques dans l'ordre des ''colonnes'', c'est-a-dire, des grandes subdivisions scientifiques du C.E.A. (auteurs)

  5. Recent advances in the V and V of the new french cea APOLLO3® neutron transport code. Benchmarks analysis of the flux solvers

    International Nuclear Information System (INIS)

    This paper presents a synthesis of the latest advances in the Verification and Validation (V and V) process of the new French (CEA) deterministic neutron transport code APOLLO3® developed within the framework of a common CEA, AREVA and EDF project. It focuses more precisely on the generic V and V of the main transport flux solvers of the code (namely IDT, Minaret, Pastis, TDT and Minos,) through 1D to 3D international benchmarks (ZPR-1D, Stepanek, C5G7, Takeda). Precise criteria have been defined to assess the quality of each solver by comparison with TRIPOLI4® multigroup Monte-Carlo calculations that have been performed for each configuration. We show that pure transport flux solvers (IDT, Minaret, Pastis and TDT-MOC) based on Sn , Pn and characteristics methods meet the keff target precision criteria (100 pcm) whereas SPn solver (Minos) give satisfactory results within reasonable computation time. The complementary of the APOLLO3® flux solvers set is globally highlighted. (author)

  6. Diverse characteristics of 111In labelled anti-CEA monoclonal antibodies for tumour immunoscinitigraphy: Radiolabelling, biodistribution and imaging studies in mice with human tumour xenografts

    International Nuclear Information System (INIS)

    Three monoclonal anti-CEA antibodies, designated 161, 198 (both IgG1) and 228 (IgG2a) have been labelled with 111In via DTPA chelation and assessed for localization in human gastro-intestinal carcinomas as xenografts in athymic nude mice. Following reaction of the antibodies with DTPA anhydride, efficiency of chelation of 111In varied between the antibodies with mean values of 30%, 52% and 62% with 161, 198 and 228 respectively. Gel filtration chromatography with all three labelled antibodies showed radiolabel predominantly coincident with IgG with little radioactivity in either high molecular weight form or as free 111In. However, the efficiency of binding of radiolabelled antibodies to CEA producing tumour cells varied, with maxima of 42%, 65% and 20% for 161, 198 and 228. In vivo, in mice, 111In was excreted at virtually identical rates (half times approx. 12 days) with all three prepartions and this was similar to the clearance of indium injected as 111In-indium chloride, but 111In-DTPA was rapidly eliminated (half time approximately 5 h). (orig.)

  7. Preparation, biodistribution, and dosimetry of 188Re-Labeled MoAb ior cea1 and its f(ab')2 fragments by avidin-biotin strategy

    International Nuclear Information System (INIS)

    The biotinylated monoclonal antibody (MoAb) ior cea1 and its F(ab')2 fragments were labeled with Re-188 by combination of avidin-biotin strategy. 188Re-MoAb, 188Re-MoAb-biotin, 188Re-F(ab')2, and 188Re-F(ab')2-biotin preparations were produced for these studies with specific activities of 1.30±0.18 GBq/mg and from instant freeze-dried kit formulations using ethane-1-hydroxy-1,1-diphosphonic acid (EHDP) as a weak competing ligand. There were no significant differences (p>0.05) between the biodistribution in mice of biotinylated and unbiotinylated 188Re-labeled immunoconjugates. When avidin was injected as a chase after injection of 188Re-MoAb-biotin or 188Re-F(ab')2-biotin, the blood radioactivity level decreased approximately 75% (cumulated activity) and the effective dose decreased almost 25% with respect to that of the radioimmunoconjugates in which the chase effect was not used. Our results suggest that 188Re-labeled biotinylated MoAb ior cea1 and its F(ab')2 fragments prepared by this method are stable complexes in vivo

  8. The current CEA/DRN safety approach for the design and the assessment of non-electrical applications of nuclear heat

    International Nuclear Information System (INIS)

    This paper presents the basis of the safety approach currently implemented by the Commissariat a l'Energie Atomique - Nuclear Reactor Directorate (CEA/DRN), both for the design and the assessment of innovative systems and future nuclear installations. It is considered that the described approach is applicable to the plants built for non-electrical applications of nuclear heat. This is typically the case of Nuclear Desalination Installations. This approach is the result of the experience maturated, within the context of the CEA/DRN Innovative Programme, through practical applications over several future concepts (both fission and fusion plants). The background of this experience is structured coherently with the European Safety Authorities recommendations, the European Utilities Requirements (EUR) and the ''fundamental safety objectives'' defined by the IAEA. The Defence In Depth principle and its application, by means, among others, of the barrier concept, remains the basis of the safety design process of future nuclear installations. Its adequacy is checked through the safety assessment. The methodology for Lines of Defence (LOD) implementation as well as the one for the LOD architecture assessment is shown and motivated. The document shows that the clear and unambiguous definition of the safety approach provides an essential base for the organisation of the design tasks, being sure that the safety aspects are correctly taken into account and implemented, and for an adequate safety assessment of the final design, both from qualitative point of view as well as for the quantitative safety analysis. (author)

  9. Qualification of a laser cutting process for nuclear dismantling operations AREVA NC BU Valorisation - CEA/DPAD - IRSN/DSU/SERAC

    International Nuclear Information System (INIS)

    A major decommissioning project is under way on the Marcoule French Atomic Site (CEA) at the UP1 reprocessing plant where AREVA plays the role of prime contractor. Due to severe radiological levels on certain cells, these require remote operations. The cutting tools commonly used today are mainly mechanical such as grinders, saws and hydraulic shears. Nowadays, the feed-back shows that the implementation of these mechanical techniques: *?Is the main factor of mechanical failures of the remote arms. *?Requires a lot of spare parts (saw blades, discs...) The future cutting operations to be done in the UP1 reprocessing plant needs to be more industrial and productive. That is why CEA and AREVA NC are evaluating a new cutting process based on a laser set up on a remote arm. The laser cutting is already widely used in none nuclear environment and the goal is to evaluate if this thermal process may be used in nuclear installations with existing remote control arms. (authors)

  10. Las ericáceas de la vertiente pacífica de Nariño, Colombia

    Directory of Open Access Journals (Sweden)

    Betancur Julio

    2005-07-01

    (Cavendishia oligantha, Diogenesia alstoniana y Vaccinium sp. nov. y las seis restantes son compartidas con la región  limítrofe del norte del Ecuador. Tres especies (Cavendishia callista, Disterigma pseudokillipiella y Macleania smithiana fueron exclusivas de la llanura del Pacífico (por debajo de 500 m de altitud, 31 especies de la región Andina (por encima de 500 m de altitud y 19 se compartieron entre ambas regiones.
    La mayor riqueza de especies y endemismos se presentó entre 1.000 y 1.600 m de altitud, con 45 especies. Los resultados obtenidos muestran que la vertiente pacífica del departamento de Nariño, Colombia, es la región de América con mayor número de especies de ericáceas por unidad de área.

  11. ACCELERATED AGING OF OLERACEOUS SPECIES SEEDS ENVELHECIMENTO ACELERADO DE SEMENTES DE ESPÉCIES OLERÁCEAS

    Directory of Open Access Journals (Sweden)

    Denis Santiago da Costa

    2011-07-01

    the seedling formation process.

    A qualidade da semente utilizada no processo de produção agrícola é um dos principais fatores considerados para a implantação da cultura. Este trabalho objetivou estudar o efeito do nível de vigor no desempenho de sementes de seis espécies oleráceas. Sementes comerciais de alface, berinjela, brócolis, couve-flor, rúcula e tomate foram submetidas ao envelhecimento acelerado, por 48 e 72 horas, para obtenção de lotes com três níveis de vigor. Obteve-se um lote normal e dois envelhecidos por diferentes períodos. Após a obtenção dos lotes, as sementes foram submetidas a testes de germinação, condutividade elétrica, emergência de plântulas em bandeja, comprimento e massa seca de plântulas. O efeito do envelhecimento acelerado torna-se mais acentuado com o aumento do tempo de exposição das sementes às condições de alta umidade relativa do ar e elevada temperatura. Esta exposição reduz, mais acentuadamente, a qualidade das sementes para algumas espécies, como alface, couve-flor e rúcula, que para outras, como brócolis, tomate e berinjela. Sementes de menor vigor, além de menor germinação e menor emergência, apresentam lentidão no processo de formação de mudas.

  12. Chemistry of complexing molecules and environment. Report of the working group of the Cea ''mission environment''; Chimie des complexants en environnements. Rapport du groupe de travail de la mission environnement

    Energy Technology Data Exchange (ETDEWEB)

    Petit, J.C

    1998-07-01

    The Working group 'Chemistry of Complexing Molecules and Environment' of the Mission Environment (AG/ENV) identified themes for an original positioning of CEA on important issues of environmental research if a sufficiently strong demand appears. The research of CEA on the environment should be complementary to actions undertaken by other partners (official institutions, research organizations and industrial firms). The themes suggested are: the synthesis of new chelating molecules and new materials having specific properties, with the support of theoretical chemistry and modeling, analytical physical chemistry and speciation of species in relation to their eco-toxicity and their biogeochemical mobility in the natural environment. These themes, illustrated by examples of actions in progress at CEA or likely to be launched quickly, draw largely from recognized competences of the teams, generally developed for finalized nuclear applications: experimental, theoretical and instrumental competences. (author)

  13. Uso da capilaroscopia ungueal como método diagnóstico e prognóstico de rosácea Nailfold capillaroscopy as a diagnostic and prognostic method in rosacea

    OpenAIRE

    Gabriela Poglia Fonseca; Fabiane Mulinari Brenner; Carolina de Souza Muller; Adma Lima Wojcik

    2011-01-01

    FUNDAMENTOS: Não há um método adequado e fidedigno de avaliação e seguimento da severidade na rosácea. OBJETIVO: Determinar a importância da capilaroscopia periungueal como método diagnóstico e prognóstico em pacientes portadores de rosácea. MÉTODOS: Estudo transversal onde foram submetidos ao exame da capilaroscopia periungueal 8 pacientes com rosácea e 8 controles no período entre maio e julho de 2009. Foram coletados dados clínicos relacionados ao sexo, idade, fototipo, classificação da ro...

  14. Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer

    International Nuclear Information System (INIS)

    Cathepsin B and L (CATB, CATL), urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 play an important role in colorectal cancer invasion. The tumor marker utility and prognostic relevance of these proteases have not been evaluated in the same experimental setting and compared with that of CEA and CA-19-9. Protease, CEA and CA 19-9 serum or plasma levels were determined in 56 patients with colorectal cancer, 25 patients with ulcerative colitis, 26 patients with colorectal adenomas and 35 tumor-free control patients. Protease, CEA, CA 19-9 levels have been determined by ELISA and electrochemiluminescence immunoassay, respectively; their sensitivity, specificity, diagnostic accuracy have been calculated and correlated with clinicopathological staging. The protease antigen levels were significantly higher in colorectal cancer compared with other groups. Sensitivity of PAI-1 (94%), CATB (82%), uPA (69%), CATL (41%) were higher than those of CEA or CA 19-9 (30% and 18%, respectively). PAI-1, CATB and uPA demonstrated a better accuracy than CEA or CA 19-9. A combination of PAI-1 with CATB or uPA exhibited the highest sensitivity value (98%). High CATB, PAI-1, CEA and CA 19-9 levels correlated with advanced Dukes stages. CATB (P = 0.0004), CATL (P = 0.02), PAI-1 (P = 0.01) and CA 19-9 (P = 0.004) had a significant prognostic impact. PAI-1 (P = 0.001), CATB (P = 0.04) and CA 19-9 (P = 0.02) proved as independent prognostic variables. At the time of clinical detection proteases are more sensitive indicators for colorectal cancer than the commonly used tumor markers. Determinations of CATB, CATL and PAI-1 have a major prognostic impact in patients with colorectal cancer

  15. Agreement on scientific and technical co-operation in the peaceful uses of nuclear energy between the National Laboratory of Industrial Engineering and Technology (LNETI) and the Commissariat a l'Energie Atomique (CEA)

    International Nuclear Information System (INIS)

    This Agreement on scientific and technical co-operation in the nuclear field was signed between the French Atomic Energy Commission (CEA) and the Portuguese National Laboratory of Industrial Engineering and Technology (LNETI). The Agreement covers, inter alia, research in the safety of nuclear installations and radiation protection; radioisotope applications; radioecology; environmental studies and the impact of nuclear energy on the environment. The Agreement, which became operational on the date of its signature by both Parties will remain in force for ten years. A Protocol, also signed on 27th November 1980 under the Agreement, defines the general conditions for scientific and technical co-operation between the CEA and the LNETI. (NEA)

  16. Vulnerabilidad de los sistemas de polinización de cactáceas columnares de México Vulnerability of pollination systems of columnar cacti of Mexico

    Directory of Open Access Journals (Sweden)

    Alfonso Valiente-Banuet

    2002-03-01

    Full Text Available Se presenta un análisis geográfico sobre el grado de vulnerabilidad de los sistemas de polinización de cactáceas columnares de México que muestran un síndrome de polinización quiropterófila. Se partió del supuesto que sistemas especializados de polinización serían más vulnerables a la perturbación humana que los generalistas. Los resultados indican que las especies que se ubican en el límite norte de la distribución de las cactáceas columnares muestran patrones generalistas de polinización que las hace menos vulnerables a las perturbaciones que las que habitan el centro de México que presentan sistemas de interacción especializados. Este patrón contrastante podría estar relacionado con los movimientos migratorios de los murciélagos en el norte de la distribución de las cactáceas que pudo haber restringido la respuesta hacia la especialización, en tanto que poblaciones residentes de murciélagos en el centro de México podrían haber favorecido la especialización localAn analysis of the degree of vulnerability of the pollination systems of Mexican columnar cacti showing a chiropterophyllous pollination syndrome was conducted, assuming that specialized pollination interactions would be more vulnerable to human perturbations. The results indicate that the species inhabiting the northern distribution limit of the columnar cacti show generalized pollination systems whereas species inhabiting central Mexico showing specialized pollination interactions would be more vulnerable to perturbations. This contrasting geographic pattern might be related to the migratory movements of the nectar-feeding bats in the northern limit of distribution of the columnar cacti that restricted local specialization, whereas resident nectar-feeding bat populations in south-central Mexico probably favored local specialization

  17. A survey of natural irradiation in France: description and first results of the Commissariat a l'Energie Atomique (CEA) program

    International Nuclear Information System (INIS)

    A survey of the population exposure to natural sources of radiation has been undertaken by the CEA. It is carried out at the level of 'administrative subdivisions'; in each subdivision, 400-500 calcium sulfate dosimeters have been exposed during some 6 months, outside and inside dwellings. In the first subdivisions studied the mean values for external exposure from terrestrial radiation are ranging between 43 and 109 mrad.an-1 (extreme point values: 16 and 258 mrad.an-1) outdoors, and between 43 and 120 mrad.an-1 (extreme point values: 14 and 287 mrad.an-1) indoors. As an average, indoor doses are about 10% higher than outdoor doses. As a complement to this study natural radionuclide concentrations have been determined in wheat samples in some ten regions since 1973. Radium 226 concentrations vary between 0.3 and 4.5 pCi.kg-1. Indoor measurements of radon daughter products will also be carried out

  18. Radioimmunoimaging of human colon carcinoma grafted into nude mice using 131I-labeled monoclonal anti-CEA antibody (C50)

    International Nuclear Information System (INIS)

    131I-labeled monoclonal anti-CEA antibody C50 was injected intraperitoneally into nude mice bearing human colon carcinoma xenografts for tumor localization and radioimmunoimaging studies. Radioimmunoimaging and biodistribution was performed at the 1st, 2nd, 3th, 4th and 6th day after injection and transplanted tumors were visualized in 24 hr by SPECT. Satisfactory tumor imaging was obtained at 48 hr after injection and at the 6th day T/NT (tumor/colon) reached 10.40 +- 0.69. These in vivo studies demonstrate the specificity of McAb C50 and indicate that it may be used for clinical diagnosis and targeting treatment of human colon carcinoma

  19. List of reports in the field of reactor safety research sponsored by BMFT, CEA, EPRI, JSTA and USNRC. Reported period: April 1 - June 30, 1987

    International Nuclear Information System (INIS)

    The list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning single problems in the field of reactor safety research. According to the cooperation of the Federal Minister for Research and Technology (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programme of the BMFT, reporting organization. The list of reports appears quarterly. (orig.)

  20. Advanced analysis of the CEA-NEA/OECD WWER-1000 coolant transient benchmark with the coupled system code ATHLET/BIPR-WWER

    International Nuclear Information System (INIS)

    Recent studies showed the necessity of a detailed modelling of the core outlet region of the WWER-1000 reactor where the thermocouples are located. Solving of this problem is of primary importance for the validation of the coupled system code ATHLET/BIPR-WWER on local parameters. Therefore, special attention is paid on the reactor pressure vessel model and its nodalization schema and in particular the fluid mixing phenomena at assemblies' outlets. For this purpose additional thermal-hydraulic channels modelling the flow along the guide tubes are introduced in the reactor core. With the new advanced modelling again the benchmark problems of Phase 1 of the CEA-NEA/OECD WWER-1000 Coolant Transient Benchmark are analysed. On the base of data comparison with the experimental measurements (Phase 2, Exercise 1) the mixing phenomena at assembly head is estimated and mixing coefficients are introduced in the thermal-hydraulic core outlet models of the coupled system code ATHLET/BIPR-WWER (Authors)

  1. Systems assessment of water savings impact of controlled environment agriculture (CEA) utilizing wirelessly networked Sense•Decide•Act•Communicate (SDAC) systems.

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Jonathan T.; Baynes, Edward E., Jr.; Aguirre,Carlos (University of Texas at El Paso, El Paso, TX); Jordan, Jon (University of Arizona, Tucson, AZ); Giacomelli, Gene (University of Arizona, Tucson, AZ); Waggoner, Justin (New Mexico State University, Las Cruces, NM); Loest, Clint (New Mexico State University, Las Cruces, NM); Szumel, Leo; Nakaoka, Tyler; Pate, Ronald C.; Berry, Nina M.; Pohl, Phillip Isabio; Aguirre, Francisco Luis (Invernaderos y Maquinaria Aguirre, Cd., Aldama, Chihuahua, Mexico); Aguilar, Jose (University of Texas at El Paso, El Paso, TX); Gupta, Vipin P.; Ochoa, Juan (University of Texas at El Paso, El Paso, TX); Davis, Jesse Zehring; Ramos, Damian (University of Texas at El Paso, El Paso, TX)

    2005-02-01

    Reducing agricultural water use in arid regions while maintaining or improving economic productivity of the agriculture sector is a major challenge. Controlled environment agriculture (CEA, or, greenhouse agriculture) affords advantages in direct resource use (less land and water required) and productivity (i.e., much higher product yield and quality per unit of resources used) relative to conventional open-field practices. These advantages come at the price of higher operating complexity and costs per acre. The challenge is to implement and apply CEA such that the productivity and resource use advantages will sufficiently outweigh the higher operating costs to provide for overall benefit and viability. This project undertook an investigation of CEA for livestock forage production as a water-saving alternative to open-field forage production in arid regions. Forage production is a large consumer of fresh water in many arid regions of the world, including the southwestern U.S. and northern Mexico. With increasing competition among uses (agriculture, municipalities, industry, recreation, ecosystems, etc.) for limited fresh water supplies, agricultural practice alternatives that can potentially maintain or enhance productivity while reducing water use warrant consideration. The project established a pilot forage production greenhouse facility in southern New Mexico based on a relatively modest and passive (no active heating or cooling) system design pioneered in Chihuahua, Mexico. Experimental operations were initiated in August 2004 and carried over into early-FY05 to collect data and make initial assessments of operational and technical system performance, assess forage nutrition content and suitability for livestock, identify areas needing improvement, and make initial assessment of overall feasibility. The effort was supported through the joint leveraging of late-start FY04 LDRD funds and bundled CY2004 project funding from the New Mexico Small Business Technical

  2. Las Poáceas del Parque Nacional Yanachaga-Chemillén (Oxapampa, Perú. Parte II: Pooideae, Centothecoideae, Arundinoideae, Chloridoideae y Panicoideae

    Directory of Open Access Journals (Sweden)

    María I. La-Torre

    2013-06-01

    Full Text Available Se presenta la segunda parte de un estudio taxonómico de la Familia Poaceae del Parque Nacional Yanachaga-Chemillén y zonas aledañas (Oxapampa, Pasco, Perú. Se presentan 63 especies de Poáceas de las subfamilias Pooideae, Centothecoideae, Arundinoideae, Chloridoideae y Panicoideae, las cuales están incluidas en 37 géneros y 12 tribus. Se incluye una breve descripción de los géneros. Se ha elaborado claves para diferenciar los géneros y especies. Para cada especie se indica su ecología, distribución y el material estudiado.

  3. Key Performance Criteria Affecting the Most the Safety of a Nuclear Waste Long Term Storage : A Case Study Commissioned by CEA

    International Nuclear Information System (INIS)

    As part of the work scope set in the French law on high level long lived waste R and D passed in 1991, CEA is conducting a research program to establish the scientific basis and assess the feasibility of long term storage as an option for the safe management of nuclear waste for periods as long as centuries. This goal is a significant departure from the current industrial practice where storage facilities are usually built to last only a few decades. From a technical viewpoint such an extension in time seems feasible provided care and maintenance is exercised. Considering such long periods of time, the risk for Society of loosing oversight and control of such a facility is real, which triggers the question of whether and how long term storage safety can be actually achieved. Therefore CEA commissioned a study (1) in which MUTADIS Consultants (2) and CEPN (3) were both involved. The case study looks into several past and actual human enterprises conducted over significant periods o f time, one of them dating back to the end of the 18th century, and all identified out of the nuclear field. Then-prevailing societal behavior and organizational structures are screened out to show how they were or are still able to cope with similar oversight and control goals. As a result, the study group formulated a set of performance criteria relating to issues like responsibility, securing funds, legal and legislative implications, economic sustainable development, all being areas which are not traditionally considered as far as technical studies are concerned. These criteria can be most useful from the design stage onward, first in an attempt to define the facility construction and operating guiding principles, and thereafter to substantiate the safety case for long term storage and get geared to the public dialogue on that undertaking should it become a reality

  4. A look at new key performance criteria that could most affect the safety of long term storage of nuclear waste. A case study commissioned by CEA

    International Nuclear Information System (INIS)

    As part of the work scope set in the French law on high level long lived waste R and D passed in 1991, CEA is conducting research work to establish the scientific basis and assess the feasibility of long term storage as an option for the safe management of nuclear waste for periods as long as a few centuries. This goal is a significant departure from current industrial practice where storage facilities are usually built to last only a few decades. From a technical viewpoint such an extension in time seems feasible provided care and maintenance is exercised. Considering such long periods of time risk for Society of loosing oversight and control of such a facility is real which triggers the question of whether and how long term storage safety can be actually achieved. Therefore CEA commissioned a study in which MUTADIS Consultants and CEPN were both involved. The case study looks into several past and actual human enterprises conducted over significant periods of time - one dating back to the end of the 18th century - and identified off the nuclear field. Then-prevailing societal behaviour and organizational structures are screened out to show how they were and are still able to cope with similar oversight and control goals. As a result the study group obtained a set of performance criteria relating to issues like responsibility, securing funds, legal and legislative implications, economic sustainable development, all being areas which are not traditionally considered when technical studies are conducted. These criteria can be most useful from the design stage onward, first in an attempt to define the facility construction and operating guiding principles, and thereafter to substantiate the safety case for long term storage and get geared to the public dialogue on that undertaking should it become a reality. (author)

  5. CEA contribution to the analysis of the control rod withdrawal test performed during PHENIX end-of-life experiments. IAEA common research program

    International Nuclear Information System (INIS)

    In 2007 the IAEA, within the framework of the Technical Working Group on Fast Reactors (TWG-FR) activities, decided to launch a Coordinated Research Project (CRP), devoted to benchmarking analyses on 'Control Rod Withdrawal Test' performed during the 'PHENIX End-of-Life Experiments'. This test program was conducted by the CEA, EDF and AREVA before the final shutdown of the prototype power fast reactor PHENIX in order to gather important data and knowledge about several aspects of the operation and safety of pool-type sodium-cooled fast reactors. The overall CRP objective was to improve the participants' analytical capabilities in various fields of research and design of sodium-cooled fast reactors. Among the accident sequences that are to be taken into account, inadvertent withdrawal of a control rod is considered. During operation at nominal power, such a sequence induces a general power increase and local deformations of the power shape. Afterwards, the local fuel temperature increases can thereby lead to fuel melting and clad failure. The quasi-static control rod withdrawal test was especially designed to gather power local data on fissile sub-assemblies and to complete validation databases of neutronic codes. The maximal deformation of the power shape reached ±12% and was obtained when two control rods were shifted in opposite directions. After a description of the test and the measurement methods, this paper presents some results obtained in the course of the test with special emphasis on control rod efficiencies and power deformation by subassemblies. This paper also discusses CEA results obtained in the course of the benchmark with the European neutronic code used for fast reactors design, ERANOS-2.2. (author)

  6. Multi-modality treatment of primary nonresectable intrahepatic cholangiocarcinoma with 131I anti-CEA--a Radiation Therapy Oncology Group Study

    International Nuclear Information System (INIS)

    Thirty-seven patients with primary nonresectable intrahepatic cholangiocarcinoma (57% with prior treatment and/or metastasis) were prospectively treated with external radiation, chemotherapy, and 131I labelled anti-CEA. Therapy began in all trials with whole liver irradiation (21.0 Gy, 3.0 Gy/Fx, 4 days/week, 10 MV photons) with alternate treatment day chemotherapy (Adriamycin, 15 mg + 5-FU, 500 mg). One month after external beam therapy, chemotherapy was given (Adriamycin, 15 mg + 5-FU, 500 mg) followed the next day by the first administration of 131I anti-CEA. The treatment schedule used was 20 mCi day 0; 10 mCi day 5 as an outpatient. This schedule was derived from tumor dose estimates which indicated that 20 mCi (8-10 mCi/mg IgG) was sufficient to achieve tumor saturation with a tumor effective half-life of 3 to 5 days, depending upon the species of animal from which the antibody was obtained. The median tumor dose for the 20 mCi + 10 mCi regimen was 6.2 Gy. Antibody therapy was delivered in 2-month cycles using antibody generated in different species of animals; rabbit, pig, monkey, and bovine. Toxicity was limited to hematologic toxicity and was manifested as thrombocytopenia and leukocytopenia (3.2% Grade IV for each according to RTOG toxicity criteria). Tumor remission evaluated by CT scan digitized tumor volume analysis indicated a 26.6% partial response (PR). Tumor remission by physical examination indicated a 33.3% remission rate (25.9% PR and 7.4% complete remission (CR]. The median survival for patients who responded was 15.2 months. The actuarial median survival for the entire group of patients (metastases and previous treatment) was 6.5 months. The longest partial remission is presently more than 4 years

  7. Multi-modality treatment of primary nonresectable intrahepatic cholangiocarcinoma with /sup 131/I anti-CEA--a Radiation Therapy Oncology Group Study

    Energy Technology Data Exchange (ETDEWEB)

    Stillwagon, G.B.; Order, S.E.; Klein, J.L.; Leichner, P.K.; Leibel, S.A.; Siegelman, S.S.; Fishman, E.K.; Ettinger, D.S.; Haulk, T.; Kopher, K.

    1987-05-01

    Thirty-seven patients with primary nonresectable intrahepatic cholangiocarcinoma (57% with prior treatment and/or metastasis) were prospectively treated with external radiation, chemotherapy, and /sup 131/I labelled anti-CEA. Therapy began in all trials with whole liver irradiation (21.0 Gy, 3.0 Gy/Fx, 4 days/week, 10 MV photons) with alternate treatment day chemotherapy (Adriamycin, 15 mg + 5-FU, 500 mg). One month after external beam therapy, chemotherapy was given (Adriamycin, 15 mg + 5-FU, 500 mg) followed the next day by the first administration of /sup 131/I anti-CEA. The treatment schedule used was 20 mCi day 0; 10 mCi day 5 as an outpatient. This schedule was derived from tumor dose estimates which indicated that 20 mCi (8-10 mCi/mg IgG) was sufficient to achieve tumor saturation with a tumor effective half-life of 3 to 5 days, depending upon the species of animal from which the antibody was obtained. The median tumor dose for the 20 mCi + 10 mCi regimen was 6.2 Gy. Antibody therapy was delivered in 2-month cycles using antibody generated in different species of animals; rabbit, pig, monkey, and bovine. Toxicity was limited to hematologic toxicity and was manifested as thrombocytopenia and leukocytopenia (3.2% Grade IV for each according to RTOG toxicity criteria). Tumor remission evaluated by CT scan digitized tumor volume analysis indicated a 26.6% partial response (PR). Tumor remission by physical examination indicated a 33.3% remission rate (25.9% PR and 7.4% complete remission (CR). The median survival for patients who responded was 15.2 months. The actuarial median survival for the entire group of patients (metastases and previous treatment) was 6.5 months. The longest partial remission is presently more than 4 years.

  8. R and D on early detection of the Total Instantaneous Blockage for 4. Generation Reactors - Inventory of non-nuclear methods investigated by the CEA

    International Nuclear Information System (INIS)

    In the safety analysis for the core of the 4. Generation Reactors, the Total Instantaneous Blockage (TIB) is a hypothetic accident scenario involving the melting of the blocked subassembly with a risk of propagation to the neighbouring subassemblies. To avoid this latter consequence a detection system has to scram the reactor. For Superphenix or EFR project a Delayed Neutron Detection Integrated (DND I) was considered as efficient to limit the melting to the first neighbouring subassemblies. Nonetheless for the CFV core the objective of improving the safety leads to limit the melting to the blocked subassembly. For this purpose, the CEA has launched a program development to find a new detection method. This paper provides a brief review of the feedback of R and D, progress and program on the various early non-nuclear detection methods investigated by the CEA: - Temperature measurement at the subassemblies outlet by thermocouples. The advantage of this method is that it will require no additional instrumentation to that already present for continuous monitoring. - Temperature measurement at the subassemblies outlet by Optical Fibers Bragg Grating (OFBG). This technology has the electromagnetic immunity, compactness and short response time. - Temperature measurement at the subassemblies outlet by ultrasound. The measuring point is located closer to the head subassembly and the response time could be shorter. - Acoustic detection of sodium boiling. Boiling occurs early in the accident progress and the area to be monitored may be covered by few sensors. - Subassemblies loss of flow detection by eddy-current flowmeters. This method seems logically the easiest and the most immediate method to detect a blockage. To date, none of these methods has been fully demonstrated to be feasible. It should be noted that temperature measurement methods will probably consist of the detection of a low increase rate using specific signal processing. These methods have been compared

  9. The effect of high level natural ionizing radiation on expression of PSA, CA19-9 and CEA tumor markers in blood serum of inhabitants of Ramsar, Iran

    International Nuclear Information System (INIS)

    Since several high level natural radiation areas (HLNRAs) exist on our planet, considerable attention has been drawn to health issues that may develop as the result of visiting or living in such places. City of Ramsar in Iran is an HNLRA, and is a tourist attraction mainly due to its hot spas. However, the growing awareness over its natural radiation sources has prompted widespread scientific investigation at national level. In this study, using an ELISA method, the level of expression of three tumor markers known as carcinoembryonic antigen (CEA), prostate-specific antigen (PSA) and carcino antigen 19-9 (CA19-9) in blood serum of 40 local men of Ramsar (subject group) was investigated and compared to 40 men from the city of Noshahr (control group). Noshahr was previously identified as a normal level natural radiation area (NLNRA) that is some 85 km far from Ramsar. According to statistical analysis, there was a significant difference in the levels of PSA and CA19-9 markers between the two groups (p < 0.001) with those of Ramsar being considerably higher. CEA level did not show any difference. Although some of the volunteers tested positive to the markers, they were in good health as confirmed by the physician. Moreover, the high number of positive markers in Noshahr was considerable. Therefore, future study is needed to further validate this result and to determine the level of positivity to tumor markers in both cities. -- Highlights: • Expression of three tumor markers was examined in 80 volunteers from Ramsar. • There was a significant difference in the levels of PSA and CA19-9 markers. • Some of the volunteers from the control city of Noshahr also tested positive. • Radiation might have caused an adaptive response in people of Ramsar. • Further study is necessary to re-confirm the positivity to tumor marker

  10. Key Performance Criteria Affecting the Most the Safety of a Nuclear Waste Long Term Storage : A Case Study Commissioned by CEA

    Energy Technology Data Exchange (ETDEWEB)

    Marvy, A.; Lioure, A; Heriard-Dubreuil, G.; Gadbois, S.; Schneider, T.; Schieber, C.

    2003-02-24

    As part of the work scope set in the French law on high level long lived waste R&D passed in 1991, CEA is conducting a research program to establish the scientific basis and assess the feasibility of long term storage as an option for the safe management of nuclear waste for periods as long as centuries. This goal is a significant departure from the current industrial practice where storage facilities are usually built to last only a few decades. From a technical viewpoint such an extension in time seems feasible provided care and maintenance is exercised. Considering such long periods of time, the risk for Society of loosing oversight and control of such a facility is real, which triggers the question of whether and how long term storage safety can be actually achieved. Therefore CEA commissioned a study (1) in which MUTADIS Consultants (2) and CEPN (3) were both involved. The case study looks into several past and actual human enterprises conducted over significant periods o f time, one of them dating back to the end of the 18th century, and all identified out of the nuclear field. Then-prevailing societal behavior and organizational structures are screened out to show how they were or are still able to cope with similar oversight and control goals. As a result, the study group formulated a set of performance criteria relating to issues like responsibility, securing funds, legal and legislative implications, economic sustainable development, all being areas which are not traditionally considered as far as technical studies are concerned. These criteria can be most useful from the design stage onward, first in an attempt to define the facility construction and operating guiding principles, and thereafter to substantiate the safety case for long term storage and get geared to the public dialogue on that undertaking should it become a reality.

  11. Radioactive waste storage at the CEA Centre in Cadarache; transfer from the -storage yard- to the CEDRA facility: an illustration of changes in the safety requirements

    International Nuclear Information System (INIS)

    A lot of changes have been made to the nuclear waste storage and disposal strategy over the last few years thanks to technological progress and changes in the requirements applicable in the sector. In this article, the authors present a concrete example of the actions undertaken, at the request of the French Nuclear Safety Authority (ASN), by the CEA Centre at Cadarache, regarding the Cadarache Centre waste storage facility (BNI 56), a facility which was originally intended as a permanent repository for solid waste. Commissioned in 1969, BNI 56 is made up of various trenches and pits which no longer meet current ASN requirements. To clean up these trenches, a legacy from the past, now requires considerable resources and involves many problems, especially due to uncertainty surrounding the nature, activity levels, packaging and volume of this waste. ASN ensures that the CEA will fully assume its overriding responsibility in the matter and implement safe, rigorous and transparent management solutions for all the waste. The BNI 56 trenches are an ongoing and concrete example of the difficulties inherent in recovering waste from storage and dismantling former facilities the design of which failed to take such aspects into account. This waste is now being repackaged so that it can be stored at a new basic nuclear installation called CEDRA (packaging and storage of radioactive waste) which complies with the safety requirements currently in force. This facility, commissioned in 2006, is intended for the storage of Type B solid radioactive waste for a period of 50 years pending construction of a deep geological repository or long-term storage facility. (authors)

  12. Avaliação dos valores sérico e pleural dos marcadores tumorais CEA, CYFRA21-1 e CA 15-3 em portadores de derrame pleural Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in patients with pleural effusion

    OpenAIRE

    Isabella Coimbra Wagner; Murilo José de Barros Guimarães; Lilian Karine Neves da Silva; Francisco Montenegro de Melo; Maria Tereza Cartaxo Muniz

    2007-01-01

    OBJETIVO: Dosar os marcadores tumorais antígeno carcinoembrionário (CEA), fragmento da citoqueratina 19 (CYFRA21-1) e antígeno glicosídico associado a tumor 15-3 (CA 15-3) em sangue e líquido pleural de portadores de derrames pleurais benignos e malignos, avaliando a sensibilidade de cada um deles nesses fluidos. MÉTODOS: Avaliamos prospectivamente 85 pacientes com derrame pleural. O estudo do líquido pleural obedeceu a critérios determinados pela literatura. A dosagem dos marcadores foi real...

  13. Studies of monoclonal antibodies IOR-CEA-1 and IOR-EGF/R3 labelled with {sup 99m}Tc; Estudo de marcacao dos anticorpos monoclonais IOR-CEA-1 e IOR-EGF/R3 com {sup 99m}Tc

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Carla Roberta de Barros Rodrigues

    2005-07-01

    Nuclear Medicine is a speciality that uses radioisotopes for the diagnosis or treatment of diseases and it is considered one of the best tools among the diagnostic modalities for detection of cancer. {sup 99m}Tc is one of the main isotopes for labelling antibodies and in Nuclear Medicine in general, due to its adequate physical properties, availability and low cost. Labelled monoclonal antibodies have shown promising results for diagnosis and therapy of cancer and their use has brought great experimental and clinical advances in the field of oncology. The main clinical applications of immunoscintigraphy with monoclonal antibodies are staging and evaluation of tumoral reappearance. The antibodies employed in this work were: OIR-CEA-1, a murine monoclonal antibody that acts directly against CEA expressed in several neoplasia in particular those from the gastrointestinal tract (colorectal cancer) and IOR-EGF/R3, a murine monoclonal antibody that binds to the external domain of EGF-R and it has been used in the diagnosis of tumors of epithelial origin. The objectives of this work were the development and optimization of the reduction and purification processes, the radiolabelling techniques and quality control procedures (radiochemical, immunoreactivity and cystein challenge) and imaging studies of monoclonal antibodies OIR-CEA-1 and IOR-EGF/R3, using the simple, fast and efficient method of direct labelling of the antibody with {sup 99m}Tc. The final results was the definition of the best conditions for the preparation of lyophilized reactive kits of OIR-CEA-1 and IOR- EGF/R3 for an efficient diagnostic application in Nuclear Medicine. The most adequate conditions for the labelling of the antibodies were: 1.0 mg Ab, 29 {mu}L MDP, 3.0 {mu}g Sn{sup 2+}, 1 mL of {sup 99m}Tc and 30 min. reaction time. With these conditions the labelling yield was always higher than 95% and the maximum activity of {sup 99m}Tc was about 2220 MBq (60 mCi). The evidences of the efficiency and

  14. The CT Findings and the Peak SUV on PET/CT according to the Levels of Cyfra 21-1 and CEA in Patients with Non-Small Cell Lung Carcinoma

    International Nuclear Information System (INIS)

    We wanted to evaluate the CT findings and the peak SUV according to the levels of cyfra 21-1 and CEA in patients with non-small cell lung carcinoma (NSCLC). We evaluated the TNM staging, cell types, the CT findings and peak SUV of the NSCLC in 234 patients with NSCLC according to the tumor marker levels. The correlations of the CT findings and the peak SUV with the tumor markers were evaluated in 35 patients with stage I disease. The sensitivities of the combined tumor markers cyfra 21-1 and CEA in the NSCLC for each TNM staging (I-IV) were 48.5%, 66.7%, 78.3% and 84.3%, respectively (p<0.05). Cyfra 21-1 was more sensitive for squamous cell carcinoma and CEA was more sensitive for adenocarcinoma. The tumor size, tumor necrosis and peak SUV were greater in the NSCLC with an elevated cyfra 21-1 level than that in the NSCLC without an elevated cyfra 21-1 level (p<0.05). For stage I disease, the level of cyfra 21-1 was linearly correlated with the tumor size (r=0.54) and the peak SUV (r=0.46), and the level of CEA was high in the spiculated masses (p<0.05). The NSCLC with an elevated cyfra 21-1 level shows larger, more frequently necrosis and a higher peak SUV than the NSCLC without an elevated Cyfra 21-1 level. For stage 1 disease, the tumor size and peak SUV correlate with the level of cyfra 21-1, and spiculated masses show an elevated level of CEA

  15. Effect of paclitaxel liposome combined with nedaplatin on serum HE4, CA125, CA19-9, AFP, CEA and T lymphocyte subsets in patients with advanced ovarian cancer

    Institute of Scientific and Technical Information of China (English)

    Su-Yu Zhu; Jie Tan; Chen-Lu Zhang; Qun-Ying Wu; Xue-Xin Xie; Hua-Fang Yin

    2016-01-01

    Objective:To study the effect of paclitaxel liposome combined with nedaplatin on serum HE4, CA125, CA19-9, AFP, CEA and T lymphocyte subsets in patients with advanced ovarian cancer.Methods:A total of 80 patients with advanced ovarian cancer in our hospital from December 2012 to December 2015 were enrolled in this study. The subjects were divided into control group (n=40) and experiment group (n=40) randomly. The control group were treated with paclitaxel and cisplatin, the experiment group were treated with paclitaxel liposome combined with nedaplatin. 21 days for a period of treatment and the two groups were treated for 3 periods. The serum HE4, CA125, CA19-9, AFP, CEA levels and peripheral blood CD3+, CD4+, CD8+ and NK cells of the two groups before and after treatment were compared. Results:There were no significantly differences of the serum HE4, CA125, CA19-9, AFP, CEA level and peripheral blood CD3+, CD4+, CD8+ and NK cells of the two groups before treatment (P>0.05). The serum HE4, CA125, CA19-9, AFP and CEA level of the two groups after treatment were significantly lower than before treatment (P<0.05), and that of experiment were significantly lower than control group (P<0.05). The peripheral blood CD3+, CD4+, CD8+and NK cells of the two groups after treatment were significantly lower than before treatment (P<0.05), and that of experiment were significantly higher than control group (P<0.05). Conclusions:Paclitaxel liposome combined with nedaplatin can significantly reduce the serum HE4, CA125, CA19-9, AFP and CEA levels, improve peripheral blood CD3+, CD4+, CD8+ and NK levels of patients with advanced ovarian cancer, and it was worthy clinical application.

  16. The clinical value of 99Tcm-HL91 hypoxia imaging combined with the detection of serum NSE, CEA and CYFRA21-1 in the diagnosis of lung cancer

    International Nuclear Information System (INIS)

    Objective: To investigate the value of 99Tcm-HL91 hypoxia imaging combined the detection of serum neuron-specific enolase (NSE), carcinoembryonic antigen(CEA) and cytokeratin 19 fragment (CYFRA21-1) in the diagnosis of lung cancer. Methods: 63 patients with lung neoplasm were carried out 99Tcm-Hail hypoxia imaging, and the serum tumor markers levels of Nose, Cea and CYFRA21-1 were detected. The sensitivity, specificity and accuracy of each and combined method were calculated respectively and compared with each other. Results: The sensitivity,specificity and accuracy in diagnosis of lung cancer with 99Tcm-HL91 hypoxia imaging were 85.4%, 100% and 88.9% respectively; and with serum tumor markers NSE, CEA and CYFRA21-1 detection were 72.9%, 86.7% and 76.1% respectively. Compared with the detection of serum tumor marker levels of NSE, CEA and CYFRA21-1, 99Tcm-HL91 hypoxia imaging had the higher sensitivity and specificity,and similar accuracy. The sensitivity, specificity and accuracy of combined two methods in diagnosis of lung cancer were 95.8%, 86.7% and 93.6% respectively. The sensitivity and accuracy of the combined method were significantly increased than single method (P0.05). Conclusion: 99Tcm-HL91 hypoxia imaging and the detection of serum level of NSE, CEA and CYFRA21-1 have an important diagnostic value, and their combination could improve the sensitivity and accuracy in the diagnosis of lung cancer. (authors)

  17. Presentation of IngeniumTM, software tool for manage and share information and knowledge, and some applications in nuclear domain, with the CEA

    International Nuclear Information System (INIS)

    Full text: Principles. New technology allow the communication, exchange and sharing of many information. Search engine fit the profile of users more and more providing relevant document. But it's not enough to create a real collective thrust where everyone can express its own point of view, to confront it with the others, to enrich it while laying out the evolution of the argument. Furthermore, we realize the over-abundance of information, the difficulty to operate it and the increasing enrichment of the immaterial capital which is made of knowledge and know-how of the firm's staff. It's a very concrete and daily problem, in a lot of domain, everywhere we need information to act. The quality and relevance of founded solution contribute to the success of the firm or of the concerned group : how not to lose information, not to make again what is already done, not to waste time to find what exist, to share, to think with other, to lay out this thought and decision which ensue? In face of the several dimension of knowledge management procedural (organizational), cognitive (power is in the capability to operate the information) and instrumental (software tool, linguistic search engine and network), we offer multiple answer: methodological coaching and set a tool going, fitting best to requirement, individual and collective. Like AI, KM focus thought management, but unlike AI, instead of trying to formalize a problem's resolution by the automation of a reasoning, we now look for providing to the operator the information he need to resolve himself the problem, individually or collectively. We so make the bet, determinedly, of the user's intelligence, relying on its own cognitive capacity to operate at best the provided information. Ingenium software. Its on the above ideas that was build the Ingenium software, trying to answer to underlined requirement, ensuring employment easiness, share, subjectivity and relevance. Its inside Jean Michel Penalva's laboratory (CEA) that

  18. Presentation of IngeniumTM, software tool for manage and share information and knowledge, and some applications in nuclear domain with the CEA

    International Nuclear Information System (INIS)

    (CEA) that several prototype were processed, relying on internal project teams. Once the prototype and ideas validated, we decide to industrialize this approach, from which become IngeniumTM software and associated coaching. The IngeniumTM software is an intranet environment, real service integrated to the team work, which offer: Collecting and storage of document and laying out thought process by subjective and individual contribution, designed as 'knowledge element'. The knowledge base doesn't force neither hierarchy, nor key words, nor specific interrogating language. Access is distributed and scratched by Internet or Intranet with a usual browser and a standard viewer (Acrobat ReaderTM). The idea is to find without classify. The access control to the information and their protection, ensured by login and password (even encryption), structured by group and level. Three principles hold up the software's realization: the maximal learn ability for user, the relevance of answer, and the ability to give a personal and subjective advice. Two use case Nuclear: capitalization and sharing of knowledge. The CEA team of Saclay responsible of missions concerning some nuclear installations has decided to equip itself with IngeniumTM. Composed of ten people, the team feed the base with documents and expert advice, making up an information base more and more complete. This base hold at one and the same time qualified document and enrichment associated to expertise and know-how of the contributors. Non-nuclear: Assistance to Installation. The CEA CSN of Cadarache has decided also to equip itself with IngeniumTM, for optimizing the management of information and knowledge required. Two items have got priority, shared with the installation team: - The follow-up of the events constitutive of the installation life: incident, control or inspection visit, modification demand, and so on. - Putting communally the statutory directive: map of 'statutory alert' allowing an easy access to the

  19. Clorofíceas marinhas bentônicas da Praia de Serrambi, Pernambuco, Brasil Benthic marine Chlorophyceae from Serrambi Beach, Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Sônia Maria Barreto Pereira

    1998-04-01

    Full Text Available É apresentado o levantamento florístico sobre as clorofíceas marinhas bentônicas encontradas na Praia de Serrambi, litoral Sul do Estado de Pernambuco. O material estudado foi coletado em três estações, as quais foram visitadas mensalmente durante o período de abril de 1986 a setembro de 1987. As clorofíceas foram representadas na flora local por 39 espécies, três variedades e uma forma, pertencentes às ordens Ulotrichales, Ulvales, Siphonocladales, Cladophorales, Caulerpales e Dasycladales. Acetabularia calyculus Quoy & Gaimard. In Freycinet, Bryopsis pennata Lamouroux, Bryopsis plumosa (Hudson C. Agardh, Caulerpa ambigua Okamura, Caulerpa serrulata (Forsskål J. Agardh emend Børgesen, Chaetomorpha brachygona Harvey, Cladophora coelothrix Kützing, Cladophoropsis membranacea (C. Agardh Børgesen, Codium intertextum Collins & Hervey, Ernodesmis verticillata (Kützing Børgesen são novas referências para a flora do litoral de Pernambuco. Pringsheimiella scutata (Reinke von Höhnel ex Marchewianka o é também para o litoral continental do Brasil. Halimeda opuntia (L. Lamouroux foi hospedeira de maior número de epífitas, enquanto Bryopsis plumosa, quando epífita, foi a que cresceu sobre maior número de hospedeiros.This survey presents studies about benthics marine chlorophyceae found in the Serrambi Beach, South coast of Pernambuco. The material studied was collected in three stations, which were visited monthly during the period from April, 1986 to September, 1987. The chlorophyceae were represented in this flora by 39 species, three varieties and one form, from orders Ulotrichales, Ulvales, Siphonocladales, Cladophorales, Caulerpales and Dasycladales. Acetabularia calyculus Quoy & Gaimard. In Freycinet, Bryopsis pennata Lamouroux, Bryopsis plumosa (Hudson C. Agardh, Caulerpa ambigua Okamura, Caulerpa serrulata (Forsskål J. Agardh emend Børgesen, Chaetomorpha brachygona Harvey, Cladophora coelothrix Kützing, Cladophoropsis

  20. Anti-CEA aptamers labeled with 99mTc: encapsulation studies in long-circulating and pH-sensitive liposomes, biodistribution and imaging

    International Nuclear Information System (INIS)

    Colorectal cancer (CRC) is one of the leading cancers and the carcinoembryonic antigen (CEA) is a tumor marker widely used in diagnosis since it is overexpressed in tumor cells. Acid nucleic aptamers with high affinity and specificity for this antigen become promising molecules for CRC diagnosis by imaging. However, due to the action of nucleases in vivo, they have been investigated for association with liposomes, such as long-circulating and pH-sensitive liposomes (SPHL) that can be destabilized in the tumor region releasing aptamers and contributing to the CRC diagnosis by scintigraphy. In this work, SpHL containing DOPE, CHEMS and mPEG2000-DSPE were characterized by analyzing mean diameter, polydispersity index and zeta potential. The anti-CEA aptamers Apt3 and Apt3-Amino were labeled with technetium-99m and the encapsulation efficiency (EE) of 99mTc-Apt3 in the SpHL by dehydration-rehydration (modified DRV) and freeze-thaw (FT) were analyzed, both in the presence of cryoprotectants. Biodistribution and scintigraphic images were performed at 1h and 4h post-injection of 99mTc-Apt3-amino, 99mTc-Apt3-SpHL or 99mTc-Apt3-amino-SpHL complexes in Balb/c healthy mice. The SpHL dispersions were homogeneous. The radiolabeling yield with technetium-99m was over 90% for all complexes. By the dehydration-rehydration method, the SpHL increased over 200% after encapsulation procedure. By the freeze-thaw method, the SpHL size increased only 13.7%. Free 99mTc-Apt3-amino showed to be cleared by renal via with high levels of radioactivity in the kidney and bladder, however, the 99mTc-Apt3-SpHL and 99mTc-Apt3-amino-SpHL clearly indicated high uptake by liver and spleen. The biodistribution of 99mTc-Apt3-SpHL showed significant uptake of radioactivity by stomach and thyroid indicating less stability of the Apt3 radiolabelling in relation to Apt3-amino. (author)

  1. Anti-CEA aptamers labeled with {sup 99m}Tc: encapsulation studies in long-circulating and pH-sensitive liposomes, biodistribution and imaging

    Energy Technology Data Exchange (ETDEWEB)

    Leonel, M.F.V.; Andrade, A.S.R. [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Oliveira, M.C.; Cardoso, V.N.; Barros, A.L.B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Farmacia

    2015-07-01

    Colorectal cancer (CRC) is one of the leading cancers and the carcinoembryonic antigen (CEA) is a tumor marker widely used in diagnosis since it is overexpressed in tumor cells. Acid nucleic aptamers with high affinity and specificity for this antigen become promising molecules for CRC diagnosis by imaging. However, due to the action of nucleases in vivo, they have been investigated for association with liposomes, such as long-circulating and pH-sensitive liposomes (SPHL) that can be destabilized in the tumor region releasing aptamers and contributing to the CRC diagnosis by scintigraphy. In this work, SpHL containing DOPE, CHEMS and mPEG{sub 2000}-DSPE were characterized by analyzing mean diameter, polydispersity index and zeta potential. The anti-CEA aptamers Apt3 and Apt3-Amino were labeled with technetium-99m and the encapsulation efficiency (EE) of {sup 99m}Tc-Apt3 in the SpHL by dehydration-rehydration (modified DRV) and freeze-thaw (FT) were analyzed, both in the presence of cryoprotectants. Biodistribution and scintigraphic images were performed at 1h and 4h post-injection of {sup 99m}Tc-Apt3-amino, {sup 99m}Tc-Apt3-SpHL or {sup 99m}Tc-Apt3-amino-SpHL complexes in Balb/c healthy mice. The SpHL dispersions were homogeneous. The radiolabeling yield with technetium-99m was over 90% for all complexes. By the dehydration-rehydration method, the SpHL increased over 200% after encapsulation procedure. By the freeze-thaw method, the SpHL size increased only 13.7%. Free {sup 99m}Tc-Apt3-amino showed to be cleared by renal via with high levels of radioactivity in the kidney and bladder, however, the {sup 99m}Tc-Apt3-SpHL and {sup 99m}Tc-Apt3-amino-SpHL clearly indicated high uptake by liver and spleen. The biodistribution of {sup 99m}Tc-Apt3-SpHL showed significant uptake of radioactivity by stomach and thyroid indicating less stability of the Apt3 radiolabelling in relation to Apt3-amino. (author)

  2. Enraizamento de estacas herbáceas de guaranazeiro em diferentes substratos Survival rate of guarana herbaceous cuttings in different substrates

    Directory of Open Access Journals (Sweden)

    Murilo Rodrigues de Arruda

    2007-02-01

    Full Text Available A utilização de sementes na propagação do guaranazeiro propicia alta variabilidade na produtividade e suscetibilidade a doenças, por isto, no Amazonas, recomenda-se a propagação do guaranazeiro por meio do enraizamento de estacas herbáceas de materiais selecionados. Objetivou-se com este trabalho, avaliar o enraizamento, em tubetes, de estacas herbáceas de doze clones de guaranazeiro submetidas a três diferentes substratos. Os clones avaliados foram o BRS 300, BRS 871, BRS 372, BRS 648, BRS 189, BRS 505, BRS 610, BRS 612, BRS 850, BRS 882, BRS 608, BRS 611. Os substratos testados foram uma mistura com base em volume de 50 % de solo + 50 % de esterco de galinha (v/v; 50 % de esterco de galinha + 50 % de carvão moído passado em peneira de 10 mm (v/v e substrato comercial para hortaliças (Plantmax®. O substrato comercial e o esterco de galinha + carvão proporcionaram a maior porcentagem de enraizamento das estacas. O clone BRS Amazonas obteve o maior percentual de enraizamento (88,2 %, enquanto o clone BRS 372, o menor (15 %.The propagation of the guarana plants using seeds is nowadays not recommended because the high variability in the productivity and susceptibility to diseases. The cuttings propagation of a select guarana plant clones is recommended for Amazonas State. The objective of this study was to evaluate the survival rate of cuttings of twelve clones of guaraná in three substrates with three replicates. The evaluated clones were: BRS 300, BRS 871, BRS 372, BRS 648, BRS 189, BRS 505, BRS 610, BRS 612, BRS 850, BRS 882, BRS 608, BRS 611. The growing media tested were 50% of soil + 50% of chicken manure (v/v; 50% chicken manure + 50% sieved powdered charcoal (v/v and a comercial growing media for vegetables (Plantmax®. The comercial growing media and the misture of chicken manure + sieved powdered charcoal substrate produced the higher cuttings survival rate. The clone BRS Amazonas showed the highest percentage of survival

  3. Construction of predictive models for radionuclide diffusion in sedimentary rocks applied to radioactive waste deep storage: approach and overview of the CEA research program

    International Nuclear Information System (INIS)

    Full text of publication follows: Deep geological storage is studied in France as one of the three potential options for managing long lived nuclear waste in the framework of the 1991 Law. One of the key topics of research deals with the behaviour of radionuclides in the geological environment, focusing in particular on the diffusion process within the rock. The final aim is to develop validated and reliable long-term predictive migration models. These researches are mainly coping with Jurassic-age Callovo-Oxfordian argilites. They include first some characterizations performed on core samples (diffusion tests, characterisation of porosity properties, chemical retention measurements). In fact, tests on small samples in diffusion cells under laboratory conditions are essential to obtain diffusion parameters used in safety calculations because they allow selection and control of experimental physical and chemical conditions and therefore constitute the principal tools for understanding and quantifying the underlying phenomena such as the effect of temperature, water composition, and lithological properties of the rocks. As a consequence, CEA performed for more than ten years several hundredths of through diffusion tests involving inert, anionic and cationic radioactive tracers on argilites and limestone samples. Tests conducted in diffusion cells do however have limitations because they apply to small samples. In addition, tests performed in surface laboratories are confronted with uncertainties relating to the determination of the in-situ water composition. Moreover, samples used in the surface laboratory may have been subjected to mechanical and chemical disturbances before the actual performance of the tests. It is therefore necessary to validate the extrapolation of the characterisation results of transport properties to larger scales. In-situ experiments help then in analysing the representativeness of physical models and associated parameters and support the

  4. TUMOR MARKER CA125、 CA153、 CA199 AND CEA IN LUNG CANCER%肿瘤标记物CA125、CA153、CA199与CEA 在肺癌诊断中的意义

    Institute of Scientific and Technical Information of China (English)

    谢汉华

    2001-01-01

    目的:研究四种肿瘤标记物CA125、CA153、CA199与CEA在肺癌诊断中的意义,并以常见的几种呼吸道炎症性疾病(RIDs)作为对照。结果:肺癌患者CA125、CA153、CA199及CEA水平均显著高于RIDs患者(P<0.001),而CA125、CA153、CA199及CEA水平在肺癌的三种组织学类型和各期肺癌中并显著性差异(P>0.05)。采有四项指标的平均值作为标准,虽然并不能显著提高诊断的灵敏度(P>0.05),但可显著提高诊断的特异性(P<0.05或0.01)。结论:CA125、CA153、CA199及CEA可作为肺癌的标记物,检测这四项标记物在临床上具有一定的辅助意义。%Four tumor markers,CA125,CA153,CA199 and CEA are studied for their relations with lung cancer,using Respiratory Inflammatory Diseases,RIDs (bronchitis,bronchiectasis and pneumonia)as control.The result shows that the serum levels of CA125,CA153,CA199 and CEA are significantly higher in the patients with lung cancer than in those with RIDs(P<0.001).There are not significant differences of the serum level of CA125,CA153,CA199 and in different tissular types of lung cancer and at different phases of lung cancer (P>0.05).The mean value of the four markers is used for a new standard for judging lung cancer.The sensitivity is not significantly higher,but the specificity is significantly lifted(P<0.05 or 0.01).It seems that CA125,CA153,CA199 and CEA can be useful markers for lung cancer,and that the detection of the four markers can play assistant role in the judgement of lung cancer.

  5. 血清CEA,CA125,NSE,CYFRA21-1联合检测对肺癌的诊断价值%Diagnostic Value of Combined Determination of Serum Tumor Markers (CEA, CA 125, NSE, CYFRA 21-1 ) Levels in Patients with Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    黄芳; 耿燕; 李婷婷; 张西英

    2008-01-01

    目的 探讨血清癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白片段21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)联合检测对肺癌的诊断价值.方法 采用电化学发光法对78例肺癌(其中鳞癌30例,腺癌28例,小细胞癌20例)、45例肺部良性病患者和36例健康人血清进行分析.结果 肺癌患者血清4种肿瘤标志物含量明显高于肺部良性疾病组(P<0.05)和健康对照组(P<0.01).肺癌组经病理分型后,NSE在小细胞肺癌中的水平明显高于其他类型的肺癌(P<0.05);CYFRA21-1的水平在鳞癌中升高尤为明显(P<0.05);CEA的水平在腺癌中显著升高(P<0.05).4种肿瘤标志物单项检测时,特异度较高(82.22%~95.56%),但敏感度不是很高(38.46%~56.41%).联合检测后,可提高肺癌的阳性检出率(64.10%).结论 CEA,CA125,NSE和CYFRA21-1对肺癌有一定的辅助诊断价值,且CEA,NSE和CYFRA21-1对不同组织类型肺癌均有一定诊断价值,联合检测可提高对肺癌的阳性诊断.

  6. Economic utility of Cea-scan ; (acetobromo) immunoscintigraphy in the evaluation of patients with colorectal cancer: a retrospective financial analysis based on published clinical studies

    International Nuclear Information System (INIS)

    The aim of this analysis was to evaluate whether or not the added cost of immunoscintigraphy with Cea-Scan (arcitumomab) to routine anatomic imaging, can reduce the overall cost of patient management in patients with colorectal cancer. Methods: Two hundred ten (210) colorectal cancer patients underwent preoperative CT and immunoscintigraphy. The ability of CT alone and combined with immunoscintigraphy to preoperatively assess the resectability status of each patient was evaluated. Costs included were: total cost of administering and interpreting both imaging studies, total surgical costs, and the costs of false positives and false negatives (with respect to determination of resectability). An outcomes table was constructed to incorporate economic possibilities for each patient sub-group. Results: Immunoscintigraphy with arcitumomab reduced the overall cost of patient management by approximately $5,000 per patient, primarily due to those patients whom CT incorrectly indicated as resectable. Conclusion: This analysis indicates that the addition of immunoscintigraphy to the preoperative workup of patients diagnosed with colorectal cancer decreases the overall cost significantly (Au)

  7. Nuevas tecnologías desarrolladas para el aprovechamiento de las cactáceas en la elaboración de alimentos. Componentes funcionales y propiedades antioxidantes

    Directory of Open Access Journals (Sweden)

    Mónica Azucena Nazareno

    2011-06-01

    Full Text Available Las cactáceas han sido consideradas por nuestros ancestros y contemporáneos una fuente de alimento y también de medicinas. La mayoría presenta frutos y cladodios comestibles que a su vez pueden ser procesados a una amplia variedad de nuevos productos. Se ha demostrado que su consumo ofrece beneficios nutricionales y promueve la salud, y debido a esto existe un marcado interés en el desarrollo de nuevas tecnologías y la adquisición de nuevos conocimientos sobre su naturaleza química y propiedades para un mejor aprovechamiento, lo que genera nuevos estudios. En tal sentido, en este trabajo se recopiló información de la literatura que fue revisada, con el propósito de aportar una visión general sobre las nuevas tecnologías desarrolladas para el aprovechamiento de los cactus en la elaboración de alimentos con énfasis en sus componentes bioactivos y propiedades antioxidantes. Se concluye que un amplio espectro de nuevas tecnologías está siendo explorado a fin de obtener alimentos cuya función no sea solamente un aporte nutricional sino también que represente un beneficio para la salud de los consumidores.

  8. Nuevas tecnologías desarrolladas para el aprovechamiento de las cactáceas en la elaboración de alimentos. Componentes funcionales y propiedades antioxidantes

    Directory of Open Access Journals (Sweden)

    Mónica Azucena Nazareno

    2011-01-01

    Full Text Available Las cactáceas han sido consideradas por nuestros ancestros y contemporáneos una fuente de alimento y también de medicinas. La mayoría presenta frutos y cladodios comestibles que a su vez pueden ser procesados a una amplia variedad de nuevos productos. Se ha demostrado que su consumo ofrece beneficios nutricionales y promueve la salud, y debido a esto existe un marcado interés en el desarrollo de nuevas tecnologías y la adquisición de nuevos conocimientos sobre su naturaleza química y propiedades para un mejor aprovechamiento, lo que genera nuevos estudios. En tal sentido, en este trabajo se recopiló información de la literatura que fue revisada, con el propósito de aportar una visión general sobre las nuevas tecnologías desarrolladas para el aprovechamiento de los cactus en la elaboración de alimentos con énfasis en sus componentes bioactivos y propiedades antioxidantes. Se concluye que un amplio espectro de nuevas tecnologías está siendo explorado a fin de obtener alimentos cuya función no sea solamente un aporte nutricional sino también que represente un beneficio para la salud de los consumidores.

  9. CEA在肺癌和其它肺部疾病的表达%Expressions of CEA in Lung Cancer and Other Pulmonic Diseases

    Institute of Scientific and Technical Information of China (English)

    舒仁明; 何思春; 焦鑫; 王利君

    2004-01-01

    目的:探讨血清CEA检测对肺癌的诊断及与其它肺部疾病的鉴别诊断价值.方法:用贝克曼库尔特Access化学发光分析仪及配套试剂盒,测定108例肺癌和115例其它肺疾病患者血清CEA,并检测60例正常人作为对照.结果:肺癌组CEA中位数为85.10ng/ml,其它肺疾1.95 ng/ml,正常人为1.99ng/ml.肺腺癌血清CEA显著高于鳞癌和小细胞肺癌.结论:血清CEA检测有助于肺癌的诊断及与其它肺部疾病的鉴别诊断.

  10. The CEA-FRAGEMA ramp test programme for the study of the effect of power cycling on PCI at high burn-up

    International Nuclear Information System (INIS)

    The ramp test programme developed jointly by FRAGEMA and CEA is presented. Today, more than thirty PWR fuel rods have been ramp-tested in experimental reactors SILOE and OSIRIS. Nineteen fuel rods, named 'PRISCA', were base irradiated in BR3 and twelve fuel rods have been refabricated in hot cell by the FABRICE technique. The average fuel burn-up lies between 11 GWd.tU-1 and 46 GWd.tU-1. In the major cases, the flux profile, during ramp-test, was decentred with respect to the base irradiated flux, and allows to obtain much more information than with a centred flux profile. The failure threshold was established under a set of more than thirty fuel rods of various designs. In particular, the post irradiation examinations allow to locate all rupture locations and thus to define precisely the threshold condition for failure of fuel rods. As an example, the results obtained in the PRISCA 109 experiments are presented. The refabricated fuel rods FABRICE behave identically, with regard to PCI, rather than PRISCA rods. An example of load follow transient in a PWR reactor is presented, and indicates any risk of failure due to PCI. (author)

  11. Phase I/II trial of 111In-labeled anti-CEA monoclonal antibody (111In-ZCE-025) in diagnosis of colorectal cancer

    International Nuclear Information System (INIS)

    A phase I/II study of imaging with radiolabeled anti-CEA monoclonal antibody, 111In-ZCE-025, was carried out in patients with colorectal cancers as a joint research project at 5 hospitals in Japan. There were 24 patients, 22 of whom were judged to be evaluable. Nineteen had primary lesions with or without metastatic lesions, two had local recurrences, and one had only metastatic lesions. On the patient basis, 21 of the 22 (95.5%) were judged to be positive. Of the 40 known lesions, planar imaging detected 24 (60.0%), whereas combined imaging (planar and single photon emission computed tomography, SPECT) detected 29 (72.5%). Surgery disclosed another 22 new lesions, two (9.1%) of which had been detected by the planar and four (18.2%) by the combined imagings. As for the newly visualized sites, on the other hand, planar imaging depicted 10, two of which were true positives (20.0%), whereas combined imaging depicted 20 and four of them were true positives (20.0%). These low positive predictive values for newly visualized sites were due to many false positive lymph nodes. In conclusion, this method will be useful for preoperative screening and diagnosis of local recurrence of colorectal cancers. But the formation of HAMA should be taken into consideration when this method is repeatedly used. At present, for metastatic foci in lymph nodes, this method possesses only a complementary role. (author)

  12. Report on transparency and nuclear safety 2013 - Cadarache CEA centre - Tome 1. INB 32 (ATPu) et 54 (LCP) AREVA NC - Tome 2

    International Nuclear Information System (INIS)

    A first volume proposes a presentation of the Cadarache CEA centre, of its activities and installations, gives a rather detailed overview of measures related to safety and to radiation protection within these activities and installations. It also reports significant events related to safety and to radiation protection which occurred in 2013 and have been declared to the ASN. It discusses the results of release measurements (liquid and gaseous effluents, radiological assessment, and chemical assessment for various installations) and the control of the chemical and radiological impact of these gaseous and liquid effluents on the environment. It addresses the issue of radioactive wastes which are stored in the different nuclear base installations of the Centre, indicates the different measures aimed at limiting the volume of these warehoused wastes and addresses their impact on health and on the environment. Nature and quantities of warehoused wastes are specified. The second volume concerns some specific installations (INB 32 or ATPu, and INB 54 or LPC) which belong to AREVA NC. The same topics are addressed: presentation of the facilities, arrangements regarding safety and radiation protection, significant events related to safety and radiation protection, measurements of effluents and their impact on the environment, warehoused wastes. Remarks and recommendations of the CHSCT are given

  13. International Fusion Materials Irradiation Facility injector acceptance tests at CEA/Saclay: 140 mA/100 keV deuteron beam characterization

    Energy Technology Data Exchange (ETDEWEB)

    Gobin, R., E-mail: rjgobin@cea.fr; Bogard, D.; Chauvin, N.; Chel, S.; Delferrière, O.; Harrault, F.; Mattei, P.; Senée, F. [Commissariat à l’Energie Atomique et aux Energies Alternatives, CEA/Saclay, DSM/IRFU, 91191-Gif/Yvette (France); Cara, P. [Fusion for Energy, BFD Department, Garching (Germany); Mosnier, A. [Commissariat à l’Energie Atomique et aux Energies Alternatives, CEA/Saclay, DSM/IRFU, 91191-Gif/Yvette (France); Fusion for Energy, BFD Department, Garching (Germany); Shidara, H. [IFMIF/EVEDA Project Team, Obuchi-Omotedate 2-166, Rokkasho, Aomori (Japan); Okumura, Y. [JAEA, Division of Rokkasho BA Project, Obuchi-Omotedate 2-166, Rokkasho, Aomori (Japan)

    2014-02-15

    In the framework of the ITER broader approach, the International Fusion Materials Irradiation Facility (IFMIF) deuteron accelerator (2 × 125 mA at 40 MeV) is an irradiation tool dedicated to high neutron flux production for future nuclear plant material studies. During the validation phase, the Linear IFMIF Prototype Accelerator (LIPAc) machine will be tested on the Rokkasho site in Japan. This demonstrator aims to produce 125 mA/9 MeV deuteron beam. Involved in the LIPAc project for several years, specialists from CEA/Saclay designed the injector based on a SILHI type ECR source operating at 2.45 GHz and a 2 solenoid low energy beam line to produce such high intensity beam. The whole injector, equipped with its dedicated diagnostics, has been then installed and tested on the Saclay site. Before shipment from Europe to Japan, acceptance tests have been performed in November 2012 with 100 keV deuteron beam and intensity as high as 140 mA in continuous and pulsed mode. In this paper, the emittance measurements done for different duty cycles and different beam intensities will be presented as well as beam species fraction analysis. Then the reinstallation in Japan and commissioning plan on site will be reported.

  14. International Fusion Materials Irradiation Facility injector acceptance tests at CEA/Saclay: 140 mA/100 keV deuteron beam characterization.

    Science.gov (United States)

    Gobin, R; Bogard, D; Cara, P; Chauvin, N; Chel, S; Delferrière, O; Harrault, F; Mattei, P; Mosnier, A; Senée, F; Shidara, H; Okumura, Y

    2014-02-01

    In the framework of the ITER broader approach, the International Fusion Materials Irradiation Facility (IFMIF) deuteron accelerator (2 × 125 mA at 40 MeV) is an irradiation tool dedicated to high neutron flux production for future nuclear plant material studies. During the validation phase, the Linear IFMIF Prototype Accelerator (LIPAc) machine will be tested on the Rokkasho site in Japan. This demonstrator aims to produce 125 mA/9 MeV deuteron beam. Involved in the LIPAc project for several years, specialists from CEA/Saclay designed the injector based on a SILHI type ECR source operating at 2.45 GHz and a 2 solenoid low energy beam line to produce such high intensity beam. The whole injector, equipped with its dedicated diagnostics, has been then installed and tested on the Saclay site. Before shipment from Europe to Japan, acceptance tests have been performed in November 2012 with 100 keV deuteron beam and intensity as high as 140 mA in continuous and pulsed mode. In this paper, the emittance measurements done for different duty cycles and different beam intensities will be presented as well as beam species fraction analysis. Then the reinstallation in Japan and commissioning plan on site will be reported. PMID:24593497

  15. Evaluation of the use of decision-support software in carcino-embryonic antigen (CEA-based follow-up of patients with colorectal cancer

    Directory of Open Access Journals (Sweden)

    Verberne Charlotte J

    2012-03-01

    Full Text Available Abstract Background The present paper is a first evaluation of the use of "CEAwatch", a clinical support software system for surgeons for the follow-up of colorectal cancer (CRC patients. This system gathers Carcino-Embryonic Antigen (CEA values and automatically returns a recommendation based on the latest values. Methods Consecutive patients receiving follow-up care for CRC fulfilling our in- and exclusion criteria were identified to participate in this study. From August 2008, when the software was introduced, patients were asked to undergo the software-supported follow-up. Safety of the follow-up, experiences of working with the software, and technical issues were analyzed. Results 245 patients were identified. The software-supported group contained 184 patients; the control group contained 61 patients. The software was safe in finding the same amount of recurrent disease with fewer outpatient visits, and revealed few technical problems. Clinicians experienced a decrease in follow-up workload of up to 50% with high adherence to the follow-up scheme. Conclusion CEAwatch is an efficient software tool helping clinicians working with large numbers of follow-up patients. The number of outpatient visits can safely be reduced, thus significantly decreasing workload for clinicians.

  16. Dechlorination, dissolution and purification of weapon grade plutonium oxide contaminated with chlorides: tests performed in the CEA Atalante Facility for the aqueous polishing part of MOX Fuel Fabrication Facility

    International Nuclear Information System (INIS)

    During the first two to three years of operation, the MOX Fuel Fabrication Facility (MFFF) designed by Duke Cogema Stone and Webster (DCS) will receive and process low grade plutonium oxide from alternate feedstock (AFS). Some of this feedstock does not meet the specifications of material normally processed by MFFF, high grade plutonium oxide from the Pit Disassembly and Conversion Facility (PDCF). To validate the process selection and design parameters, DCS has requested the CEA (Acronym for French Atomic Energy Commission) to perform laboratory scale active tests using with weapons grade Plutonium oxide contaminated with chloride and other metallic impurities. Dechlorination, silver(II) dissolution and purification active tests have been performed in CEA Atalante Facility at Marcoule France with the same process parameters than the MFFF design parameters. The aim of this paper is to present the feed characteristics, the tests conditions and the tests results. (authors)

  17. Uso da capilaroscopia ungueal como método diagnóstico e prognóstico de rosácea Nailfold capillaroscopy as a diagnostic and prognostic method in rosacea

    Directory of Open Access Journals (Sweden)

    Gabriela Poglia Fonseca

    2011-02-01

    Full Text Available FUNDAMENTOS: Não há um método adequado e fidedigno de avaliação e seguimento da severidade na rosácea. OBJETIVO: Determinar a importância da capilaroscopia periungueal como método diagnóstico e prognóstico em pacientes portadores de rosácea. MÉTODOS: Estudo transversal onde foram submetidos ao exame da capilaroscopia periungueal 8 pacientes com rosácea e 8 controles no período entre maio e julho de 2009. Foram coletados dados clínicos relacionados ao sexo, idade, fototipo, classificação da rosácea de acordo com a classificação de Plewig e Kligman e a classificação da National Rosacea Society. Adicionalmente, avaliamos o tempo de evolução da doença e tratamentos previamente utilizados. RESULTADOS: A grande maioria das pacientes avaliadas (6 das 8 pacientes apresentavam rosácea grau I (vascular ou eritêmato-teleangiectásica. A idade média de duração da rosácea foi de 5,96 anos, sendo que 87,5% faziam tratamento com metronidazol tópico. Nenhum paciente tanto do grupo rosácea como controle demonstrou evidência de desvascularização ao exame capilaroscópico. CONCLUSÃO: A capilaroscopia periungueal apresenta um padrão inespecífico e não parece auxiliar no diagnóstico ou prognóstico da rosácea.BACKGROUND: There is no appropriate and reliable method of evaluating and monitoring severity in rosacea. OBJECTIVE: To determine the importance of nailfold capillaroscopy as a diagnostic and prognostic method for patients with rosacea. METHODS: A cross-sectional study where eight patients with rosacea and 8 control subjects were submitted to nailfold capillaroscopy from May to July 2009. We collected clinical data related to gender, age, skin phototype, and rosacea stage according to Plewig and Kligman classification and the classification of the National Rosacea Society. Additionally, we evaluated the progression of the disease and treatment therapies previously used. RESULTS: The majority of the patients evaluated (6

  18. Nôvo meio para isolamento de enterobacteriáceas e diferenciação simultânea das colônias de Proteus e Providência

    Directory of Open Access Journals (Sweden)

    Sebastião Timo Iaria

    1967-06-01

    Full Text Available Um nôvo meio é proposto para o isolamento de enterobacteriáceas. Baseia-se na propriedade de desanimar a fenil-alanina que possuem tôdas as bactérias dos grupos Proteus e Providencia. As colônias dêstes microrganismos apresentam no meio descrito coloração marrom característica. As colônias das outras enterobacteriáceas, fermentadoras rápidas ou lentas e não fermentadoras da lactose, apresentam aspecto diferente.A new culture medium for the isolation of Enterobacteriaceae is proposed. It is based on the property common to Proteus and Providence of deaminating phenylalanine. In the culture medium here proposed the colonies of the mentioned microorganisms show a characteristic brown colour. Colonies of other Enterobacteriaceas show a quite different aspect.

  19. Anatomia foliar de seis espécies de anonáceas cultivadas in vitro e em casa de vegetação Leaf anatomy of six species of Annonacea cultivated in vitro and greenhouse

    OpenAIRE

    José Raniere Ferreira de Santana; Lenaldo Muniz de Oliveira; Renato Paiva; Rodrigo Kelson Silva Resende; Evaristo Mauro de Castro; Flávia Dionísio Pereira

    2008-01-01

    A micropropagação de anonáceas poderá contribuir para a obtenção de plantios mais homogêneos e a inserção de novas espécies em sistemas produtivos. Entretanto, plantas cultivadas in vitro freqüentemente exibem alterações anatômicas e sua quantificação poderá auxiliar na obtenção de protocolos de cultivo mais eficientes. Realizou-se neste trabalho o estudo comparativo da anatomia foliar de seis espécies de anonáceas cultivadas in vitro e em casa de vegetação. Annona coriacea foi a única espéci...

  20. Fijación biológica de nitrógeno por tres fabáceas (Leguminosae) en suelos ácidos de Tabasco, México

    OpenAIRE

    S. Córdova-Sánchez; M. Castelán-Estrada; S. Salgado-García; J. D. Palma-López; J. A. Vera-Núñez; J. J. Peña-Cabriales; L. C. Lagunes-Espinoza; R. Cárdena-Navarro

    2011-01-01

    Con el objetivo de determinar el potencial de fijación biológica de nitrógeno por las fabáceas Cajanus cajan L., Canavalia ensiformis L. y Mucuna deerengiana L., en rotación y asociación con maíz durante dos ciclos de cultivo, se desarrollaron dos experimentos en un suelo ácido de la sabana de Huimanguillo, Tabasco. En ambos sistemas se evaluaron variables relacionadas con la nodulación de estas fabáceas, así como su efecto sobre el rendimiento de maíz (Zea mays L.); también se cuantificó ...