WorldWideScience

Sample records for cea la hague

  1. Epidemiological study around La Hague

    International Nuclear Information System (INIS)

    The North Cotentin is in France, the area where have been led until now, the biggest number of epidemiology studies on the effects of ionizing radiations on man, in order to assess the leukemia incidences and other cancer pathologies around nuclear facilities. The North Cotentin concentrates four nuclear installations.The objective of this file is to take stock of the situation in this field. In 1995 and 1998 have been published two sections of an epidemiology study about the incidence of leukemia in North Cotentin (J.F. Viel study for the period 1978-1992, Spira study for 1993-1997). The study of the Professor Spira does not bring to the fore a significant excess of leukemia for the period 1978-1997. The report of the professor Spira advocates several complementary epidemiology studies to precise or complete the data and lighten the causes of leukemia in North Cotentin. The studies of J.F.Viel shows that it does not exist a significant excess of cases in the studied area (25 cases for 22.8 expected cases, so a non significant difference) but notices an aggregate at the limit to be significant in the Beaumont-Hague canton (4 cases for 1.4 expected cases). J.F.Viel puts forward a relationship between the risk increase (of leukemia incidence) and some individual characteristics linked to the way of life of the studied persons: the North Cotentin beaches frequenting by the mothers or the children at least one time by month, the consumption of fish or shellfish having a local origin at least one time by week. This study suggests that it is the radioactivity, on the beaches on in fishes and shellfish that would be at the origin of the additional noticed leukemia. The authorities asked at the beginning of 1997, a scientific commission directed by the Professor Souleau to propose a new epidemiology study on the leukemia risk around La Hague. The report concludes that the leukemia incidence in the North Cotentin is in accordance with the expected incidence (25 observed

  2. Vitrification in La Hague plant achievement

    International Nuclear Information System (INIS)

    Research and development at the CEA (the French Atomic Energy Commission) about vitrification process of radioactive wastes have focused on two main points: the glass formulation to obtain the best physical, thermal and mechanical properties for the best homogeneity, stability and resistance to radiations and leaches, and the industrial process to obtain the best flexibility for the production of different homogeneous glasses and for the minimization of technological wastes. This has led to the establishment of glass specifications, agreed by the French authorities, independent commission of nuclear experts, and foreign customers, and to the construction of the R7 and T7 industrial facilities at La Hague (France) which started-up in 1989 and 1992, respectively. A description of the process units and of the quality controls are given. Various improvements have been achieved and have demonstrated the industrial mastery of vitrification of fission products. The process has proven to be flexible since fine particles from the dissolution step and alkaline effluents from the solvent regeneration steps have been incorporated to the glass matrix. (J.S.). 1 fig., 2 tabs

  3. Radioactive liquid discharges from the spent fuel reprocessing plant La Hague, France and environmental monitoring of coastal water

    International Nuclear Information System (INIS)

    This study of low-level liquid radioactive discharges from the spent fuel reprocessing plants CEA and COGEMA La Hague, prepared on the basis of existing publications and documents, is divided into studies of discharged radionuclides, morphology, sedimentology and environment of region La Hague, dispersion of discharges in seawater in the Channel, liaison of radionuclides in sediments, distribution of radionuclides in biological organisms, programme of monitoring of environment and exposition of human population

  4. La Hague Continuous Improvement Program: Enhancement of the Vitrification Throughput

    International Nuclear Information System (INIS)

    The vitrification of high-level liquid waste produced from nuclear fuel reprocessing has been carried out industrially for over 25 years by AREVA/COGEMA, with two main objectives: containment of the long lived fission products and reduction of the final volume of waste. At the 'La Hague' plant, in the 'R7' and 'T7' facilities, vitrified waste is obtained by first evaporating and calcining the nitric acid feed solution-containing fission products in calciners. The product-named calcinate- is then fed together with glass frit into induction-heated metallic melters to produce the so-called R7/T7 glass, well known for its excellent containment properties. Both facilities are equipped with three processing lines. In the near future the increase of the fuel burn-up will influence the amount of fission product solutions to be processed at R7/T7. As a consequence, in order to prepare these changes, it is necessary to feed the calciner at higher flow-rates. Consistent and medium-term R and D programs led by CEA (French Atomic Energy Commission, the AREVA/COGEMA's R and D and R and T provider), AREVA/COGEMA (Industrial Operator) and AREVA/SGN (AREVA/COGEMA's Engineering), and associated to the industrial feed back of AREVA/COGEMA operations, have allowed continuous improvement of the process since 1998: - The efficiency and limitation of the equipment have been studied and solutions for technological improvements have been proposed whenever necessary, - The increase of the feeding flow-rate has been implemented on the improved CEA test rig (so called PEV, Evolutional Prototype of Vitrification) and adapted by AREVA/SGN for the La Hague plant using their modeling studies; the results obtained during this test confirmed the technological and industrial feasibility of the improvements achieved, - After all necessary improved equipments have been implemented in R7/T7 facilities, and a specific campaign has been performed on the R7 facility by AREVA/COGEMA. The flow-rate to the

  5. Foam decontamination of the pneumatic transfer network at La Hague

    Energy Technology Data Exchange (ETDEWEB)

    Turchat, J.P.; Fournel, B. [CEA Cadarache, Dept. d' Entreposage et de Stockage des Dechets, 13 - Saint-Paul-lez-Durance (France)

    2001-07-01

    The foam cleaning process is based on the filling of an equipment with an aqueous foam containing suitable chemical reagents and, if necessary, its recirculation through a recycling loop. The major advantage of the technique is the reduction of the amount of liquid thus reducing the secondary waste production. Moreover, due to its high viscosity, the foam bed is able to carry solid contamination out of the equipment without needing a further dissolution of the solid deposit. The process has been recently experimented in La Hague on a 22 metres pipe. The pipe is part of the Pneumatic Transfer Network, which basic function is to transfer the small jugs containing liquid samples, from production points to laboratories in order to analyse them. As some contamination may incidentally exit from the jugs, it is necessary to dismantle sections of the pipe or to decontaminate the internal surfaces of the pipe essentially consisting of aluminium. The total length of the pipe network has been estimated in the range of 80 km. The CEA is working on the decontamination of the network since 1994 in association with COGEMA. A new process enabling the circulation of the foam under depression has been implemented. Furthermore, a mobile installation has been worked out by the CEA for this demonstration operation. (author)

  6. Foam decontamination of the pneumatic transfer network at La Hague

    International Nuclear Information System (INIS)

    The foam cleaning process is based on the filling of an equipment with an aqueous foam containing suitable chemical reagents and, if necessary, its recirculation through a recycling loop. The major advantage of the technique is the reduction of the amount of liquid thus reducing the secondary waste production. Moreover, due to its high viscosity, the foam bed is able to carry solid contamination out of the equipment without needing a further dissolution of the solid deposit. The process has been recently experimented in La Hague on a 22 metres pipe. The pipe is part of the Pneumatic Transfer Network, which basic function is to transfer the small jugs containing liquid samples, from production points to laboratories in order to analyse them. As some contamination may incidentally exit from the jugs, it is necessary to dismantle sections of the pipe or to decontaminate the internal surfaces of the pipe essentially consisting of aluminium. The total length of the pipe network has been estimated in the range of 80 km. The CEA is working on the decontamination of the network since 1994 in association with COGEMA. A new process enabling the circulation of the foam under depression has been implemented. Furthermore, a mobile installation has been worked out by the CEA for this demonstration operation. (author)

  7. Dosimetry optimization at COGEMA-La Hague

    International Nuclear Information System (INIS)

    At the present time, the la Hague site strives to apply international recommendations together with national regulations concerning radiation protection, and especially the respect of limitation and optimization principles. The application of these principles is based on the implementation of a passive dosimetry and an active dosimetry. The monthly passive dosimetry is monitored by means of a photographic dosimetry film, completed with lithium fluorine thermoluminescent film badges. This personal dosimetry common to X, β, γ and neutron radiations is carried out in close relationship between the Radiation Protection Department, the Occupational Medical Department and the staff running the Plant. The application or ALARA's principle as well as that of radiation protection optimization implies to implement a complementary active dosimetry enabling to gain in real time, the personal dosimetry of each intervening person, either they be COGEMA's workers or external companies'. This active dosimetry provides with following information: This preventive dosimetry is based on the knowledge of doses integration in real time and is fitted with alarm thresholds according to the total amount of doses and dose rates. Thresholds on the dose rate are also set relatively to the radiological environment. This knowledge of doses and dose rates allows a stricter management of the works, while analyzing them according to the nature of the work, to the location and to the skills of the intervening people. This dosimetry allows to analyze and optimize doses integration according to the works nature for the whole intervening staff. The la Hague Site has developed an active personal dosimetry system, common to every intervening person, COGEMA or external companies. The DOSICARD was thus elaborated, shaped as an electronic dosimeter fitted with an alarm and a smart card. The access to controlled areas is conditioned to information given by the DOSICARD concerning medical aptitudes and

  8. Waste treatment at the La Hague and Marcoule sites

    International Nuclear Information System (INIS)

    In this report, an overview of waste treatment and solidification facilities located at the La Hague and Marcoule sites, which are owned and/or operated by Cogema, provided. The La Hague facilities described in this report include the following: The STE3 liquid effluent treatment facility (in operation); the AD2 solid waste processing facility (also in operation); and the UCD alpha waste treatment facility (under construction). The Marcoule facilities described in this report, both of which are in operation, include the following: The STEL-EVA liquid effluent treatment facilities for the entire site; and the alpha waste incinerator of the UPI plant. This report is organized into four sections: this introduction, low-level waste treatment at La Hague, low-level waste treatment at Marcoule, and new process development. including the solvent pyrolysis process currently in the development stage for Cogema's plants

  9. Too much leukemia around La Hague? seems improbable

    International Nuclear Information System (INIS)

    Two French epidemiologists, Jean-Francois Viel and Dominique Pobel published in the British Medical Journal the results of their study about the number of leukemia around the reprocessing plant of La hague between 1978 and 1992 in a 35 km perimeter. The number of 25 leukemia cases( instead of 22.8 waited) is given with a number of four (instead of 1.4) in the 10 km perimeter. If the numbers are not contested, the size of the sample does not allow a real analysis of every studied factor. The hypothesis is interesting and deserves people to go further into. (N.C.)

  10. The bituminization in Marcoule and la Hague plants. Description of the processes and the fire risk prevention

    International Nuclear Information System (INIS)

    Chemical precipitation is an efficient process to decontaminate liquid effluents and has been selected as early as 1966 for the liquid waste treatment of MARCOULE. The process has been designed by the French CEA and improved along the time. The first implementation in LA HAGUE was for the STE 2 facility (Station de Traitement d'Effluents no 2). A new facility, STE 3, has been commissioned in 1989 in LA HAGUE, benefiting from these previous experience and therefore contributing into a drastic reduction of liquid discharges. The sludges coming from the treatment in MARCOULE and STE 3 are bituminized into continuous extruders. The resulting waste is kept in interim storage, waiting for final disposal. The industrial production, up to now, is close to 10000 drums (55 gallons) in LA HAGUE and 60000 drums in MARCOULE. A retrieval operation of the MARCOULE drums from the present storage has been launched to send them into a recently built interim storage operating since the beginning of 2000. At the present time, in LA HAGUE, evaporation has been preferred to chemical precipitation for the treatment of liquid effluents. After concentration, the effluents go to the vitrification and the volume of resulting waste is much smaller. However, bituminization is still the preferred option for the 10000 m3 of sludges resulting from the STE 2 operations which are being stored in tanks. A complete reevaluation of the operation safety measures of bituminization has been made lately in both plants following recent incidents on other installations. The paper describes the chemical precipitation and the bituminization processes and focuses on safety measures which are implemented for prevention, detection and fight. (authors)

  11. Safety engineering achievements in handling casks at La Hague

    International Nuclear Information System (INIS)

    Interest is focused on safety aspects of some new trends in commercial fuel reprocessing plants at La Hague. The first is the dry cask unloading, unique in size, avoiding several meters height handling and associated risks. Moreover, improvements were introduced about contamination retention, effluent decrease and contact work time, resulting in lower operators' doses. Extensive use of standard equipment, whose replacement using a special cask is foreseen as a common maintenance operation, is another major improvement for an industrial process, increasing plant availability with low personal doses compared to contact intervention. Associated crane use led to systematic studies of falling accidents and, where necessary, improved reliability crane design. It has been shown that the design and quality of corresponding elements is such that the prevention of risk is sufficient to reach a high level of safety. 1 fig

  12. Leukaemia near La Hague nuclear plant; and replies

    International Nuclear Information System (INIS)

    An article published in 1997 finding associations between childhood leukaemia and the use of beaches around La Hague nuclear fuel reprocessing plant by pregnant women and children has prompted six letters about this study. Three of these letters criticize the study suggesting that a selection bias could have been introduced into the study, the study design regarding cases and controls is questionable and insufficient attention has been given to the scientific content of their results. The fourth letter compares the results of a similar case-control study preferred in Britain. The fifth letter reports a connection between low level radiation from nuclear plants in Switzerland and malformation in leafbugs. The sixth letter is from the author of the study who attempts to provide additional information to convince the authors of the first two letters that selection or recall biases are unlikely. (UK)

  13. A world first. Industrial operation of computer-aided master-slave manipulator at the La Hague recycling plant

    International Nuclear Information System (INIS)

    Since the beginning of industrial nuclear plants like recycling, mechanical master-slave manipulators have been widely used for operation and maintenance in hot cells, in conjunction with shielding windows. In the La Hague plant for instance, all hot cells where maintenance is or could be required are fitted with shielding windows and through-wall telescopic master-slave manipulators. This well mastered solution, if used by highly skilled workers, has demonstrated its capability to perform all the maintenance tasks required, as long as equipment and tools inside the cell were designed accordingly. However, this technology has also shown significant limitations in terms of capacity, flexibility, efficiency and reliability. In order to improve those characteristics, AREVA and CEA have developed together a new technology: computer-aided master-slave manipulators. By replacing the traditional mechanical link, between the 'slave arm' in the cell and the 'master arm', with motors, sensors and electronics, this new tool improves load capacity and provides added flexibility and efficiency, while protecting the slave arm from overload and therefore improving reliability. In addition, this new device was developed to be fully compatible with current La Hague configuration. After developing and testing this solution in realistic but inactive environment, by performing all kinds of operation and maintenance activities with trained workers, the first generation tool was improved by incorporating feed-back and suggestions from operators. Second generation system was then developed, and first introduced in 2010 in an active cell of the La Hague plant, namely a vitrification cell. After a few months in operation, feedback from manufacturing staff was so positive that implementation of several new arms was decided for 2011. This paper will describe how this development benefited from the existing know-how and component library jointly developed by AREVA and CEA, as well as the main

  14. The fire prevention at Cogema La-Hague reprocessing plant; La conception de la protection contre l'incendie des ateliers de La Hague

    Energy Technology Data Exchange (ETDEWEB)

    Charbonnier, R. [Cogema la Hague, Service Surete Nucleaire, 50 - Beaumont-Hague (France)

    2000-09-01

    Nuclear facilities dedicated to the recycling of spent fuels present high risks of fire outbreak because the solvents used in chemical processes are highly combustible. The Cogema's installations in La-Hague underwent 2 important fires: in 1980 the power delivery station was destroyed by a fire and in 1981 a fire started in a silo containing graphite jackets. The policy of fire prevention at La-Hague is based on the elimination of the conditions of a fire outbreak by acting on the 3 elements of a combustion: the fuel, the ignition energy and the combustive. Acting on the fuel means reducing as much as possible the use of inflammable materials and when they are necessary being sure that they are used outside their domain of inflammability. Acting on the ignition energy means to take away any source of heat or energy from any fuel material. Acting on the combustive means having the possibility to inject inert gas like argon or nitrogen whenever it is necessary to prevent any ignition. The Cogema's installations in La-Hague are equipped with 11000 fire detectors. (A.C.)

  15. TAO2000 V2 computer-assisted force feedback tele-manipulators used as maintenance and production tools at the AREVA NC-La Hague fuel recycling plant

    International Nuclear Information System (INIS)

    During a 15-year joint research program, French Atomic Energy Agency Interactive Robotics Laboratory (CEA LIST) and AREVA have developed several remote operation devices, also called tele-robots. Some of them are now commonly used for maintenance operations at the AREVA NC (Nuclear Cycle) La Hague reprocessing plant. Since the first maintenance operation in 2005, several other successful interventions have been realized using the industrial MA23/RX170 tele-manipulation system. Moreover, since 2010, the through-the-wall tele-robot named MT200 TAO based on the slave arm of the MSM MT200 (La CalheneTM), has been evaluated in an active production cell at the AREVA NC La Hague fuel recycling plant. Although these evaluations are ongoing, the positive results obtained have led to an update and industrialization program. All these developments are based on the same generic control platform, called TAO2000 V2. TAO2000 V2 is the second release of the CEA LIST core software platform dedicated to computer aided force-feedback tele-operation (TAO is the French acronym for computer aided tele-operation). This paper presents all these developments resulting from the joint research program CEA LIST/AREVA. The TAO2000 V2 controller is first detailed, and then two maintenance operations using the industrial robot RX170 are presented: the removal of the nuclear fuel dissolver wheel rollers and the cleanup of the dissolver wheel inter-bucket spaces. Finally, the new MT200 TAO system and its evaluations at the AREVA NC La Hague facilities are discussed. (authors)

  16. 10 years of transport of vitrified High Level Waste (HLW) from COGEMA La Hague

    Energy Technology Data Exchange (ETDEWEB)

    Lancelot, J.; Martinotti, B. [COGEMA Logistics (AREVA Group) (France); Tourneux, F. [COGEMA (AREVA Group) (France)

    2004-07-01

    COGEMA has been using, for decades, its large experience of Reprocessing in both Gas Cooled reactors (GCR) and LWR fuels with the following facilities: Marcoule UP1 plant started up in late 50's: La Hague UP2 plant started up in 1966 first with GCR fuels and from 1976 with LWR Fuel (including foreign fuels): La Hague UP3 plant started up in 1990 Foreign Utilities signed Reprocessing Contracts with COGEMA from 1970's, providing returns of residues to the country of origin where they will be managed in a safe storage facility. Therefore, for nearly 30 years Spent Fuel coming from Japan, Germany, Belgium, Switzerland and the Netherlands are processed on La Hague site.

  17. 10 years of transport of vitrified High Level Waste (HLW) from COGEMA La Hague

    International Nuclear Information System (INIS)

    COGEMA has been using, for decades, its large experience of Reprocessing in both Gas Cooled reactors (GCR) and LWR fuels with the following facilities: Marcoule UP1 plant started up in late 50's: La Hague UP2 plant started up in 1966 first with GCR fuels and from 1976 with LWR Fuel (including foreign fuels): La Hague UP3 plant started up in 1990 Foreign Utilities signed Reprocessing Contracts with COGEMA from 1970's, providing returns of residues to the country of origin where they will be managed in a safe storage facility. Therefore, for nearly 30 years Spent Fuel coming from Japan, Germany, Belgium, Switzerland and the Netherlands are processed on La Hague site

  18. Nuclear energy: democracy flouted. La Hague in the center of the debate; Nucleaire: la democratie bafouee. La Hague au coeur du debat

    Energy Technology Data Exchange (ETDEWEB)

    Anger, D

    2002-07-01

    In this book, the author denounces the collusion between the French government and the nuclear lobby and the dark side of the implementation of the nuclear program in France without any real democratic debate with the citizens. The history of the La Hague radioactive waste facility is taken as an example. The author recommends the development of alternative and decentralized energy sources. He considers also that the main questions generated by the nuclear industry (radioactive wastes, spent fuels reprocessing, health hazards, environmental impact, terror threat..) are still unanswered since 30 years. (J.S.)

  19. Low and medium level liquid waste processing at the new La Hague reprocessing plant

    International Nuclear Information System (INIS)

    Reprocessing of spent nuclear fuels produces low and medium activity liquid wastes. These radioactive wastes are decontamined before release in environment. The new effluent processing plant, which is being built at La Hague, is briefly described. Radionuclides are removed from liquid wastes by coprecipitation. The effluent is released after decantation and filtration. Insoluble sludges are conditioned in bitumen

  20. Case-control study of leukaemia among young people near La Hague nuclear reprocessing plant: the environmental hypothesis revisited.

    OpenAIRE

    Pobel, D.; Viel, J F

    1997-01-01

    OBJECTIVE: To investigate the association between childhood leukaemia and established risk factors or other factors related to La Hague nuclear waste reprocessing plant. DESIGN: Case-control study. SETTING: Area within a 35 km radius of La Hague, Normandy, France. SUBJECTS: Twenty seven cases of leukaemia diagnosed during the period 1978-93 in people aged under 25 years and 192 controls matched for sex, age, place of birth, and residence at time of diagnosis. MAIN OUTCOME MEASURES: Antenatal ...

  1. Elaboration and implementation of automatized management system of operating mode at La Hague reprocessing plant

    International Nuclear Information System (INIS)

    This paper presents the documentation system for operators conducting the new units for fuel reprocessing at La Hague plant. The aim of this system, called COGEMO, is to improve man-machine system reliability, by presenting in real time to operators the information required for efficiently operating the installation in any situation (start up), transients, incidents). Qualification is developed in two shops (a mechanical and a chemical unit) and will be extended to other units when they will be put into service

  2. Optimization of the very low-level radioactive wastes volume in Cogema La Hague

    International Nuclear Information System (INIS)

    For the reprocessing plant of la Hague, the ALARA policy was principally focused until now, on the personnel dosimetry. For several years, the approach is more global and concerns the environmental impact and radioactive wastes. In this frame, an action has been started upon the wastes relative to a surface storage and with the regulatory context, it was translated by the putting in operation of a global management of very low level radioactive wastes in an ALARA approach. (N.C.)

  3. The R7/T7 vitrification at La Hague: 10 years of operation

    International Nuclear Information System (INIS)

    Vitrification of high level wastes from reprocessing of spent nuclear fuels has been carried out at La Hague on an industrial scale for ten years. This paper presents an historical overview of the facilities, and describes the facilities and their operations, startup performance, facility upgrading that has been done, and process control functions. The paper concludes that the technology for vitrification of high level wastes is mature and has been mastered. (author)

  4. Radioecological synthesis of the various compartments of La Hague (Cotentin) marine environment

    International Nuclear Information System (INIS)

    Permits for low level radioactive liquid waste releases by the LA HAGUE (Cotentin, France) fuel reprocessing plant are based on an accurate radioecological study of the marine environment. Since 1967, the monitoring of indicators such as seawater, sediments and marine organisms (Fucus serratus, Laminaria sp., Mytilus sp., ...) have made it possible to create an important environmental data base. A statistical treatment has been used to quantify the spatio-temporal (daily, seasonal, local and regional) variabilities of these indicators from 1975 up to now. It has demonstrated the interest of F. serratus seaweed as bioindicators of radioactivity. Moreover it appears that seawater-soluble radionuclides such as 125Sb and 137Cs are monitored through longer distance from the outlet than those bound to particles such as 144Ce. A study of the sestonic load by satellite images suggested a number of geographical sites of potential accumulation through particle transport, some of which were verified by radioactivity measurements of sediments. However, such accumulation was not confirmed by the particle size distribution at the level of the Cap de LA HAGUE associated with radioactive measurements of seawater. A spectral analysis of biota radioactive levels vs radioactive waste releases showed a time delay of 2 - 4 months for F. serratus and Mytilus sp. collected in the local area of LA HAGUE after either an increase or a decrease of the releases. Modeling of marine currents fields associated with a transfer model can now be used to predict, at small time scales, the radioactivity levels inthe various Cotentin marine compartments from the liquid waste releases

  5. Possible toxic effects from the nuclear reprocessing at Sellafield and Cap de la Hague

    International Nuclear Information System (INIS)

    The principal aim of this report is to assist the Committee of Petitions of the European Parliament in its consideration of Petition 393/95 brought by Dr. W. Nachtwey. The Petition expresses concerns about radioactive discharges from nuclear reprocessing plants at Sellafield in the UK and La Hague in France, and their possible adverse health effects. Six years after the Petition was introduced, the Petitioner main concerns remain relevant. This report concludes that reprocessing discharges are a valid matter for the Committee consideration. It also concludes that, on balance, the Petitioner's concerns over radioactive discharges from Sellafield and La Hague are justified. The report presents evidence and data on: 1) radioactive discharges from the Sellafield and La Hague sites; 2) resulting nuclide concentrations in environmental media including foodstuffs; 3) radiation doses from nuclide discharges to critical groups near the sites; 4) adverse health effects near the two sites; and 5) resulting collective doses from nuclide discharges. The report also examines a number of current issues in radiobiology concerning health effects from exposure to ionising radiation, in particular genetic and in utero effects. In addition, in accordance with contract specifications, the report examines other major factors that might influence future decision-making on reprocessing. It provides information on the legal framework, the operational history of the plants and the economic case for reprocessing compared with available alternatives for spent nuclear fuel management. The report also makes policy-related recommendations that take into account current knowledge and uncertainties in risk assessment and the availability of alternatives to reprocessing in spent fuel management. (authors)

  6. Implementation of remote maintenance techniques at the La Hague reprocessing plants

    International Nuclear Information System (INIS)

    The effective implementation of the safety objectives of the La Hague reprocessing plants called for several plant design criteria such as containment of radioactive materials and radiation shielding (both in normal operating conditions and off-normal conditions), equipment designs which minimize exposure from maintenance operations, and remote automated operations which can be completely controlled from the central control room. The design of the La Hague reprocessing plants incorporates innovative maintenance concepts to reduce integrated doses of maintenance personnel to ALARA levels. For instance, shearing-dissolution or vitrification cells have overhead remote maintenance cells designed for any type of preventive maintenance or repair of equipment, including replacement of certain items. Equipment and components are handled with remote wall-mounted master-slave manipulators as well as in-cell cranes. When the crane itself requires maintenance, it is brought in a ''garage'' at the extremity of the maintenance cell it services and separated from it by doors. These cranes have demonstrated good operating performance. Equipment such as pumps, valves, ejectors, vacuum filters, pH meter probes, mixer impellers require periodic maintenance during the reprocessing plants operations. This type of equipment is standardized, at La Hague, for a fast turn-around remote replacement without disconnecting process piping. Maintenance, is performed with a Mobile Equipment Replacement Cask (MERC) in a contained area, with temporary barrier modification but without breaching the containment barrier. A fleet of 19 MERCs services the plant and the MERC system has proved its reliability over the past five years in over 600 equipment replacement operations. Occupational dose linked to the operation of the remote maintenance MERC system is very low, close to the detection threshold and not contamination has resulted from it use. (author). 4 figs

  7. Possible toxic effects from the nuclear reprocessing at Sellafield and Cap de la Hague

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, M.; Coeytaux, X.; Faid, Y.B.; Marignac, Y.; Rouy, E. [Wise, 75 - Paris (France); Thompson, G. [IRSS, Cambridge (United States); Fairlie, I.; Lowry, D.; Sumner, D

    2001-11-15

    The principal aim of this report is to assist the Committee of Petitions of the European Parliament in its consideration of Petition 393/95 brought by Dr. W. Nachtwey. The Petition expresses concerns about radioactive discharges from nuclear reprocessing plants at Sellafield in the UK and La Hague in France, and their possible adverse health effects. Six years after the Petition was introduced, the Petitioner main concerns remain relevant. This report concludes that reprocessing discharges are a valid matter for the Committee consideration. It also concludes that, on balance, the Petitioner's concerns over radioactive discharges from Sellafield and La Hague are justified. The report presents evidence and data on: 1) radioactive discharges from the Sellafield and La Hague sites; 2) resulting nuclide concentrations in environmental media including foodstuffs; 3) radiation doses from nuclide discharges to critical groups near the sites; 4) adverse health effects near the two sites; and 5) resulting collective doses from nuclide discharges. The report also examines a number of current issues in radiobiology concerning health effects from exposure to ionising radiation, in particular genetic and in utero effects. In addition, in accordance with contract specifications, the report examines other major factors that might influence future decision-making on reprocessing. It provides information on the legal framework, the operational history of the plants and the economic case for reprocessing compared with available alternatives for spent nuclear fuel management. The report also makes policy-related recommendations that take into account current knowledge and uncertainties in risk assessment and the availability of alternatives to reprocessing in spent fuel management. (authors)

  8. Experience feedback of La Hague plants to the design of the Rokkasho reprocessing plant

    International Nuclear Information System (INIS)

    The two French reprocessing plants UP3 and UP2-800 of La Hague site have demonstrated very satisfactory outcomes since their active commissioning in 1990 and 1994 respectively. In particular, the outstanding decontamination and separation efficiencies recorded in the first extraction cycles have allowed to simplify the operation of the plants and enabled to launch a whole waste minimisation program. The experiences and the evolutions of these plants have been reflected to the UP3 based Japanese reprocessing plant now under construction at the Rokkasho-mura site, leading to the simplification of the design and the improvement of the plant operability. (author)

  9. Experience feedback of La Hague plants to the design of the Rokkasho reprocessing plant

    Energy Technology Data Exchange (ETDEWEB)

    Asada, Kazuo; Takaoku, Yoshinobu [Japan Nuclear Fuel Ltd., Aomori (Japan); Barandas, C.; Bernard, C.; Bretault, P.; Creusot, C.; Hugelmann, D.

    1997-12-31

    The two French reprocessing plants UP3 and UP2-800 of La Hague site have demonstrated very satisfactory outcomes since their active commissioning in 1990 and 1994 respectively. In particular, the outstanding decontamination and separation efficiencies recorded in the first extraction cycles have allowed to simplify the operation of the plants and enabled to launch a whole waste minimisation program. The experiences and the evolutions of these plants have been reflected to the UP3 based Japanese reprocessing plant now under construction at the Rokkasho-mura site, leading to the simplification of the design and the improvement of the plant operability. (author)

  10. Development of a continuous dissolution process for the new reprocessing plants at La Hague

    International Nuclear Information System (INIS)

    The French Commissariat a l'Energie Atomique has designed a continuous rotary dissolver for LWR fuel reprocessing. An industrial prototype has been tested since 1979 at the Service des Prototypes Industriels, at Marcoule. This type of dissolver will be installed at the COGEMA's Reprocessing Plants at La Hague. The advantages of a continuous process are listed, compared to batch dissolutions (chemistry, operation, capacity). The industrial prototype, featuring safe geometry, is described. The R and D program is indicated, and the main results of inactive tests already performed on the industrial prototype are given, including heating, mechanical, and chemical tests (UO2 dissolutions at 4tU per day)

  11. Zirconium-made equipment for the new La Hague reprocessing plants

    International Nuclear Information System (INIS)

    The use of zirconium was developed to solve some problems of severe corrosion in boiling nitric medium, and to guarantee the service life of the equipment concerned. The paper presents the experience gained since the early 1970s, when the first units made of zirconium were used in French reprocessing plants. For the new La Hague UP3 and UP2 800 plants, it was decided to extend the use of zirconium to make large-scale equipment and, to do so, a major R and D program was implemented, of which the main results are presented

  12. Nuclear energy: democracy flouted. La Hague in the center of the debate

    International Nuclear Information System (INIS)

    In this book, the author denounces the collusion between the French government and the nuclear lobby and the dark side of the implementation of the nuclear program in France without any real democratic debate with the citizens. The history of the La Hague radioactive waste facility is taken as an example. The author recommends the development of alternative and decentralized energy sources. He considers also that the main questions generated by the nuclear industry (radioactive wastes, spent fuels reprocessing, health hazards, environmental impact, terror threat..) are still unanswered since 30 years. (J.S.)

  13. Incidence of leukaemia in young people around the La Hague nuclear waste reprocessing plant: a sensitivity analysis

    International Nuclear Information System (INIS)

    The objectives are to investigate the incidence of childhood leukaemia in young people around the French nuclear waste reprocessing plant (La Hague, Normandy) for the period 1978-1992, and to check the sensitivity of the results to the choice of disease clustering tests and reference rates. The performance of three statistical procedures are compared: a conventional approach; a Poisson maximum test, and an extraction mapping technique. The results are in general agreement and demonstrate the apparent existence of a distinct cluster of childhood leukaemia, contiguous and south-east of the La Hague nuclear facility. (author)

  14. Case-control study of leukaemia among young people near La Hague nuclear reprocessing plant: the environmental hypothesis revisted

    International Nuclear Information System (INIS)

    The objective is to investigate the association between childhood leukaemia and established risk factors or other factors related to La Hague nuclear waste reprocessing plant. There is some convincing evidence in childhood leukaemia of a causal role for environmental radiation exposure from recreational activities on beaches. New methods for identifying the environmental pathways, focusing on marine ecosystems, are warranted. (author)

  15. Topic Number 2.1. Spent fuel reprocessing at La Hague plant: towards a zero impact

    International Nuclear Information System (INIS)

    COGEMA offers to its customers a responsible management of spent nuclear fuel: to separate valuable materials from irradiated fuels; to recycle up to 96% of nuclear materials; to safely condition the ultimate waste in long term stable matrix. In this mature industry, the achieved results are comparable to those of other industries: raw material is saved by recycling; the volume of ultimate waste is reduced by a factor of 5; as well the toxicity of ultimate waste is reduced (by a factor of 10). Despite these very good performances, the La Hague reprocessing plant is often the target of polemical attacks, suspecting that radioactive releases of the site would have an unacceptable health impact. This paper takes stock on the situation. (author)

  16. Information report on nuclear safety and radiation protection of La Hague AREVA site. Issue 2014

    International Nuclear Information System (INIS)

    Published in compliance with the French code of the environment, this report first presents the Areva's La Hague site which comprises several basic nuclear installations (INB), is dedicated to several activities related to the nuclear fuel cycle, is submitted to a constraining legal and regulatory framework, and implements a policy for a sustainable development and continuous progress. The document describes the various measures regarding nuclear safety and radiation protection, reports nuclear events which are classified according to the INES scale and occurred and had to be declared in 2014, describes the management of effluents by the different installations present on this site and the control of the environment. It addresses the waste management and the management of other impacts. It gives an overview of actions undertaken regarding information and transparency. Recommendations of the CHSCT are reported

  17. Information report on nuclear safety and radiation protection of La Hague AREVA site. Issue 2013

    International Nuclear Information System (INIS)

    Published in compliance with the French code of the environment, this report first presents the Areva's La Hague site which comprises several basic nuclear installations (INB), is dedicated to several activities related to the nuclear fuel cycle, is submitted to a constraining legal and regulatory framework, and implements a policy for a sustainable development and continuous progress. The document describes the various measures regarding nuclear safety and radiation protection, reports nuclear events which are classified according to the INES scale and occurred and had to be declared in 2013, describes the management of effluents by the different installations present on this site and the control of the environment. It addresses the waste management and the management of other impacts. It gives an overview of actions undertaken regarding information and transparency. Recommendations of the CHSCT are reported

  18. La Hague Legacy Waste Recovery Program: Scope, Progress and Issues -12080

    International Nuclear Information System (INIS)

    A significant inventory of process waste of varying natures and quantities has been generated during the thirty years of operation of UP2 400 facility on the site of La Hague, France. The retrieval, packaging and final storage of such an inventory has never been achieved before in France and thus requires the design and qualification of new processes, equipment, and waste packages. Following AREVA strategic decisions and French safety authority requirements, the legacy waste program has begun around the year 2000 and is scheduled to be completed around the year 2025. It is under the responsibility of AREVA Site Value Development Project teams. For each category of waste to be recovered, AREVA teams conducted detailed investigations, defined recovery modes, treatment processes, as well as final waste package forms, which they subsequently submitted to French safety and waste management authorities. A Task force initiative was subsequently launched to optimize the program cost and scenario, and lead to an optimization of about 15% of the entire program. The qualification of processes and waste packages required a significant amount of research and development which is now well under way for processes, and scheduled to be completed in 2015. Preparation work has begun on several installations to clear space for the construction of future retrieval facilities, scheduled to begin in the coming three years. La Hague Legacy waste retrieval program represents a significant challenge in the sense that it covers a significant variety and quantity of waste needing recovery and reconditioning, with tight financial objectives and a binding recovery schedule. During the past five years, AREVA SVD successfully conducted design, research, development, and qualification activities which lead to the definition of qualified processes and waste packages for each retrieval program. Preparation work and supplier consultations are now on-going, in order to meet our objectives of beginning

  19. Fire risk in the liquid effluent treatment station (STE3) at La Hague

    International Nuclear Information System (INIS)

    The challenge faced by the designers of the new liquid effluent treatment station (STE3) at La Hague is the non-negligible risk of fire during the lifetime of the workshop, allied to the potentially considerable consequences for personnel and the environment. In the 'bituminization' section of this workshop, the radioactive sludges generated by the decontamination of liquid effluents from the La Hague plants are dried and hot coated in bitumen. The bitumen waste product (BWP) is then poured into drums and stored after cooling. The only identified cause of a fire is an exothermic reaction during the production and cooling of the BWPs, therefore the two drum filling units were of main concern. Attention was then focused on identifying the parameters which increase the risk and on implementing the appropriate means of control. Independent of these steps, reliable detection and powerful fire fighting resources were installed. The drum filling units comprise several types of detector and temperature and pressure measurement instruments. The fire fighting resources in the drum filling units use halon and water. The latter has proved effective in fighting BWP fires which have broken out in various places around the world. The effectiveness of halon has been demonstrated in a specialized laboratory. Finally, to maintain a pressure in the drum filling units that is lower than that in the adjacent rooms, an extraction system was installed which included the washing and filtering of gases and fumes. This also permits extraction of the contaminant while fighting the fire, using the means already described. Various cases of disturbance were also envisaged (loss of electric power and individual equipment failure). A fire detection and fighting system was installed, even though the risk of fire is considered negligible in storage halls. Because of the research that has been conducted into the origins of a fire and the extremely powerful fire fighting resources made available, one

  20. Cogema experience on retrieving and conditioning solid radwaste previously stored in pits. The La Hague north west pit case

    International Nuclear Information System (INIS)

    Short lived, low and medium level waste called 'technological waste' produced by the La Hague Reprocessing Plant have been stored in the La Hague North-West concrete-lined pits until implementation at ANDRA's Centre de Stockage de la Manche (CSM). COGEMA decided to retrieve and condition 11,000 m3 of humid solid radwaste, stored in bulk in pits. This report describes the experience gained from February 1990 to December 1998, taking into account radwaste and integrated dose rate results conditioning such waste. The procedures and means used and improved by COGEMA to comply with ANDRA's storage standards and the ever-decreasing financial costs generated by the workers, allowed to retrieve and condition 11,000 m3 of old solid radwaste with competitive costs and in complete safety and protection of the environment. (authors)

  1. Order of the 23 october 2001 on the creation of a temporary forbidden zone in the area of La Hague (the English Channel)

    International Nuclear Information System (INIS)

    For the needs of the air safety mission around the nuclear power plant of La Hague (english Channel), a temporary forbidden zone (zone P) has been created since the 25 october 2001 for an undetermined time. (A.L.B.)

  2. Polyvalent fuel treatment facility (TCP): shearing and dissolution of used fuel at La Hague facility

    International Nuclear Information System (INIS)

    Although many used nuclear fuel types have already been recycled, recycling plants are generally optimized for Light Water Reactor (LWR) UOx fuel. Benefits of used fuel recycling are consequently restricted to those fuels, with only limited capacity for the others like LWR MOX, Fast Reactor (FR) MOX or Research and Test Reactor (RTR) fuel. In order to recycle diverse fuel types, an innovative and polyvalent shearing and dissolving cell is planned to be put in operation in about 10 years at AREVA's La Hague recycling plant. This installation, called TCP (French acronym for polyvalent fuel treatment) will benefit from AREVA's industrial feedback, while taking part in the next steps towards a fast reactor fuel cycle development using innovative treatment solutions. Feasibility studies and R/Development trials on dissolution and shearing are currently ongoing. This new installation will allow AREVA to propose new services to its customers, in particular in term of MOX fuel, Research Test Reactors fuel and Fast Reactor fuel treatment. (authors)

  3. A methodology for fast and accurate decay heat calculations for in-pool used fuel assemblies developed at AREVA La Hague reprocessing facility

    International Nuclear Information System (INIS)

    The evaluation of the decay heat released from used fuels stored in an interim storage pool is a crucial issue for safety and operation. This paper presents a methodology developed at the AREVA NC La Hague reprocessing facility in order to perform a fast and accurate assessment of the decay heat for a pool containing a large variety of fuel assemblies with different features (kind of reactor, initial composition, number of irradiation cycles, operating power, outage length) and cooling times ranging from 6 months to 60 years. The key aspect of the methodology relies on the fact that, for cooling times higher than 6 months, only a very short number of isotopes significantly contribute to the overall decay heat. The methodology uses results from calculations performed by the industrial depletion code CESAR and takes benefit from the experimental validation of CEA reference depletion package DARWIN. A full CESAR calculation at a given cooling time for each assembly allows building up a reference database: for any cooling time higher than the reference one, a simplified on-line calculation involving less than 30 isotopes is performed, and all approximations made are covered by the mean of biases relying on pre-evaluated coefficients. Results for an application to a 10,000-used-fuel-assembly interim storage pool are given. (author)

  4. Calibration of UP2 800 accountancy tank; Etalonnage de la cuve de comptabilite de UP2 800 (La Hague)

    Energy Technology Data Exchange (ETDEWEB)

    Cauchetier, Ph.; Roche, C. [CEA Centre d`Etudes de la Vallee du Rhone, 30 - Marcoule (France). Dept. des Procedes de Retraitement; Dufour, J.L. [CEA Centre d`Etudes de Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire; Neuilly, M.; Fournier, P.; Evain, D. [Compagnie Generale des Matieres Nucleaires (COGEMA), 78 - Velizy-Villacoublay (France); Blandeau, L.; Janin, V. [Societe Generale pour les Techniques Nouvelles (SGN), 78 - Saint-Quentin-en-Yvelines (France)

    1993-12-31

    UP2 800 plant, now on building at ``La Hague``, is equipped with an accountability tank of 20 m{sup 3} volume. That tank is used to feed the facility with solution transfers; these transfers are triggered by siphons. This paper describes calibration measures realized with that tank for setting up the curve of volume V versus the level H and for finding the volumes left after clipping of siphons. It presents also the results for the level differences between the end points of bubbling tubes. Results are given, with the corresponding accuracy, in the case of measures with water as solution. Further tests will be made with uranyl nitrate. (authors). 3 refs.

  5. COGEMA experience on retrieving and conditioning solid radwaste previously stored in pits. The La Hague North-West pit case

    International Nuclear Information System (INIS)

    Short lived, low and medium level waste called 'technological waste' produced by the La Hague Reprocessing Plant have been stored in the La Hague North-West concrete-lined pits until implementation at ANDRA's Centre de Stockage de la Manche (CSM). COGEMA decided to retrieve and condition 11,000 m3 of humid solid radwaste, stored in bulk in pits. On account of the variety of radwaste kinds, retrieving and conditioning operations represented real challenge. One goal of these operations was to ensure that the work was performed in complete safety towards environment with optimum containment and with the best radiation protection for the personnel involved. COGEMA decided to split the work into two phases. The feedback from the first phase was very helpful to the second phase. This report describes the experience gained from February 1990 to December 1998, taking into account radwaste and integrated dose rate results conditioning such waste. The procedures and means used and improved by COGEMA to comply with ANDRA's storage standards and the ever-decreasing financial costs generated by the workers, allowed to retrieve and condition 11,000 m3 of old solid radwaste with competitive costs and in complete safety and protection of the environment. (author)

  6. Conditioning hulls and end fittings of recycled used fuel: the La Hague ACC facility

    International Nuclear Information System (INIS)

    In the early 1990's, an objective was established to significantly reduce the volume of residual waste spent fuel, via the process of compaction, combined with the idea of achieving a standard canister CSD-C as its brother, the so called CSD-V (Conteneur Standard de Dechets Vitrifies in French or Universal Canister of Vitrified Waste), the concept of the Hulls and Ends Compaction Facility (ACC Atelier de Compactage des Coques in French) was born. It took ten years to design, build and develop this facility before hot start up in May 2002, at the AREVA NC La Hague site. In this paper, we explain the solutions devised to reduce waste volume by a factor of 4 through compaction and without the addition of a matrix such as concrete. Moreover the external shape of the CSD-C, identical to the CSD-V one, allows optimized handling and transfer operations of the canisters throughout all stages from production to disposal. Each step of the process will be presented: reception of hulls and ends fittings, separation and filling of casings, drying, compaction, welding. Operating results achieved from 2002 to 2008 will also be presented from both the perspective of the number of canisters produced and the volume reduction factor. During these years, improvements have been made to increase the performance of equipment and to optimize the structure of running and automation. So more than 7500 CSD C have been produced during this time. Thanks to the original design of ACC the production line can process technological waste devoted to intermediate level waste disposal. In this way, melters issued from vitrification facilities may be compacted in order to benefit from this volume reduction. Finally we present the extension of ACC's operating capabilities to include other kind of waste, such as technological waste containing a small quantity of organic, or future fuels currently in development (new types of cladding) or. with increased burn-up. Thus, the ACC facility meets its

  7. Research and test reactor fuel treatment at AREVA NC la Hague

    International Nuclear Information System (INIS)

    The La Hague plant has a long successful history of treatment power reactor spent fuel. To accommodate a new contract, the process needed to be adapted to fuel from Research Test Reactors (RTR) taking into account the dimensional characteristics, the chemical composition and the high uranium enrichment of RTR fuel. Several treatment options resulted have been studied and proposed. The chosen approach for the detailed design consists of dissolving the RTR fuel in a dissolution pit in one line of dissolver facility (T1B). The process was designed for small RTR fuel elements composed of aluminium and uranium alloy. 'Taxi' baskets containing the RTR fuel elements are transferred from the fuel storage pools, to the feed cell in T1B. The fuel elements are loaded into canisters and transferred to a rack in the general maintenance cell. The RTR fuel canisters are picked up one by one and the fuel element is dropped into a transfer tube leading to the dissolution pit. The RTR dissolution process is fundamentally different from the continuous power reactor fuel dissolution process and is done in batches. The RTR fuel elements are completely dissolved in nitric acid. It appeared that the dissolution rate is higher than expected allowing more flexibility in operation. At the end of a batch, the solution is drained from the dissolver and diluted with UOX solutions from line T1A. The resulting UOX/RTR mixture complies with the specifications for downstream processing operations, including high level waste vitrification, where aluminium is incorporated into glass in accordance with specified limits. The innovative nature of the process, demanded by the special characteristics of the RTR fuel, required a major qualification program. The main objectives of the qualification program were to validate the dissolver pit concept, to verify basic RTR process data for the T1B production environment and to acquire data showing control of the process. The first active batch dissolution was

  8. Four years of experience with the use of calculated isotopic correlations in establishing input balances at the La Hague plant

    International Nuclear Information System (INIS)

    For more than four years the La Hague reprocessing plant has been using calculated isotopic correlations to establish and check its input balances. The masses of uranium and plutonium entering the plant are determined by the gravimetric balance method, which utilizes the burnup obtained by calculated isotopic correlation as well as the Pu/U ratio measured at the dissolver after cross-checking with the values obtained by correlation. Further, a verification of all the parameters needed to establish these balances - whether physical or chemical in origin - is carried out systematically by means of internal coherence constants which make it possible to detect any anomalies in the dissolution data. The calculated isotopic correlations were evaluated when the analyses of numerous representative samples of irradiated fuel and experimental results of separated isotopic irradiation in water reactor spectra had been interpreted. The accuracy achieved was improved by allowing in the neutron calculations for effects inherent in the first reactor core and by selecting a set of calculation functions which attenuates (by compensation effects) the various perturbations in the irradiation history. The results obtained at La Hague with calculated isotopic correlations on nearly 600 t of reprocessed UO2, because of their large number and above all their high quality, suggest that it be proposed extending the method to other reprocessing plants. This could be done by the operator himself or by national or international control bodies within the framework of a safeguards arrangement. (author)

  9. Reliability of the fuel identification procedure used by COGEMA during cask loading for shipment to LA HAGUE

    International Nuclear Information System (INIS)

    This study has been carried out to demonstrate the reliability of the system of the spent fuel identification used by COGEMA and NTL prior to shipment to the reprocessing plant of La Hague. This was a prerequisite for the French competent authority to accept the 'burnup credit' assumption in the criticality assessment of spent fuel packages. The probability to load a non-irradiated and non-specified fuel assembly was considered as acceptable if our identification and irradiation status measurement procedures were used. Furthermore, the task analysis enabled us to improve the working conditions at reactor sites, the quality of the working documentation, and consequently to improve the reliability of the system. The NTL experience of transporting to La Hague, as consignor, more than 10,000 fuel assemblies since the date of implementation of our system in 1984 without any non-conformance on fuel identification, validated the formalism of this study as well as our assumptions on basic events probabilities. (J.P.N.)

  10. Assessment of marine biota doses arising from radioactive discharges to the sea by the COGEMA La Hague facility: A comprehensive case study

    International Nuclear Information System (INIS)

    The paper presents an assessment of radiation doses to marine biota arising from the radioactive sea discharges (as liquid effluents) of the COGEMA La Hague facility. The primary objective of this study was to select a representative set of marine biota for the study area (i.e. the Nord-Cotentin Peninsula coast) and to assess the potential radiological impacts, in terms of biota dose rates and their related potential health effects on marine biota, arising from the radioactive sea discharges of the COGEMA La Hague facility. For assessing potential effects to biota, the predicted biota dose rates were compared to the available guidance for the protection of populations of non-human biota. The guidance values are based on published data by international organizations (e.g. UNSCEAR and IAEA) and on a screening review of a recent database (by FASSET) on biological effects of ionizing radiation on non-human biota. The major conclusion of the case study was that the predicted dose rates to marine biota attributable to radioactive sea discharges from the La Hague facility are small, and in general, well below comparison guidance levels at which deleterious and observable health effects to populations of marine biota might, according to current knowledge, be expected. The predicted incremental dose rates arising from the La Hague facility are also, in general, well below those caused by the background radioactivity in the region. (author)

  11. Case-control study of leukaemia among young people near La Hague nuclear reprocessing plant: the environmental hypothesis revisited

    International Nuclear Information System (INIS)

    OBJECTIVE: To investigate the association between childhood leukaemia and established risk factors or other factors related to La Hague nuclear waste reprocessing plant. DESIGN: Case-control study. SETTING: Area within a 35 km radius of La Hague, Normandy, France. SUBJECTS: Twenty seven cases of leukaemia diagnosed during the period 1978-93 in people aged under 25 years and 192 controls matched for sex, age, place of birth, and residence at time of diagnosis. MAIN OUTCOME MEASURES: Antenatal and postnatal exposure to x rays and viral infections, occupational exposure of parents (particularly ionising radiation), living conditions, lifestyle of parents and children. RESULTS: Increased trends were found for use of local beaches by mothers and children (P < or = 0.01); relative risks 2.87 (95% confidence intervals 1.05 to 8.72) and 4.49 (1.52 to 15.23) when categories were aggregated in two levels (more or less than once a month). Consumption of local fish and shellfish also showed an increased trend (P 0.01); relative risk 2.66 (0.91 to 9.51) when categories were grouped in two levels (more or less than once a week). A relative risk of 1.18 a year (1.03 to 1.42) was observed for length of residence in a granite-built house or in a granitic area. No association was shown with occupational radiation exposure in parents. CONCLUSIONS: There is some convincing evidence in childhood leukaemia of a causal role for environmental radiation exposure from recreational activities on beaches. New methods for identifying the environmental pathways, focusing on marine ecosystems, are warranted

  12. Former radioactive waste storage sites: the case of the AREVA NC La Hague plant; Les anciens sites d'entreposage de dechets radioactifs: le cas de l'usine AREVA NC de La Hague

    Energy Technology Data Exchange (ETDEWEB)

    Houdre, Th. [Autorite de Surete Nucleaire, chef de la Division de Caen, 75 - Paris (France)

    2011-02-15

    Unlike AREVA NC's new UP2-800 and UP3 plants at La Hague, where the waste is conditioned in-line, the majority of waste produced while its first UP2-400 plant was still in service was stored without final packaging, at installations that no longer meet the safety requirements currently applicable. ASN believes that such storage facilities pose major safety problems. These problems are mainly related to the fact that little is known about the exact condition of certain storage facilities and the waste they contain, nor how they will evolve over time, as well as to former facility design and the inadequacy of early leak detection systems. Operations to recover this waste are technically complicated and require considerable resources and investment. As a result, the main issue as far as ASN is concerned is to ensure that the deadlines declared by AREVA are met, given that they are often dependent on the development of waste recovery procedures that do not as yet exist. For several years now, in view of the considerable delays affecting the majority of waste recovery projects, ASN has enforced the binding provisions set out under the TSN Act to set a schedule for the recovery of this old waste by prescribed dates. This situation serves to consolidate ASN's actions in requiring operators to assess, for all projects, the amount of waste generated, and to take measures for it to be processed and packaged as and when it is produced. (author)

  13. Vitrification of fission product wastes: industrial experience and construction of the new vitrification units at La Hague

    International Nuclear Information System (INIS)

    The first industrial-scale unit for vitrification of fission product wastes was commissioned at Marcoule in France in 1978. Operating experience has been applied in design and construction of the R7 and T7 units at La Hague for vitrification of fission product solutions from the new UP2-800 and UP3 reprocessing plants, (annual capacity of 1,600 tonnes of LWR spent fuel). After outlining the vitrification process, this paper presents the sustained throughput performances achieved during 9 years operation of the continuous vitrification line at Marcoule, plus information concerning technologies, maintenance, process effluents and safety. It then describes the new R7 and T7 units with their six 25 kg/hour glass production lines. Emphasis is placed on the process-related and technological changes, layout optimizations and main innovations decided to improve operation and achieve economies of scale in extrapolating from the 15 kg/hour line at Marcoule. Storage facility design for vitrified waste containers is briefly presented

  14. Simulation of the atmospheric dispersion at local scale in the area of Cogema (la Hague) using PERLE system

    International Nuclear Information System (INIS)

    METEO-FRANCE is presently developing a new system named PERLE which permits real time evaluation of atmospheric dispersion at local scale. This system consists in a non-hydrostatic meteorological model at mezo-scale (Meso-NH) and a particular code for the dispersion of the chemically passive pollutants. As a result of several studies performed by DP/SERV/ENV at Meteo-France, two particular codes have been retained for the dispersion module of PERLE: DIFPAR (EDF) and SPRAY (Aria Technologies). In this study, the dispersion at local scale of Kr 85 in the area of the nuclear-wastes reprocessing plant COGEMA (La Hague) has been simulated with the two dispersion models, initialised with the meteorological fields provided by Meso-NH. The simulations concern the most complete sampling campaign of Kr 85 performed in this area on 18th and 19th september 2001. The evaluation the two models performances and of the PERLE system's results for this campaign has been done by using the CTA (Atmospherical Transfer Coefficient) measured values. (authors)

  15. Evaluation of carbon-14 (C14) levels of terrestrial and marine food products of the environment of the site of Cogema La Hague

    International Nuclear Information System (INIS)

    This evaluation has for object to inform about the levels in carbon 14 in the environment of the factories of La Hague. Two sectors were differentiated on one hand the terrestrial environment, and on the other hand the marine environment. The investigations concerned first and foremost food products stemming as the vegetable culture (vegetables) or individual breeding (milk, eggs) but also foodstuffs stemming from the local agriculture (cereal). In touch with the second sector, the marine environment, the sampling concerned the accessible products of the sea by all and those locally marketed (fishes, molluscs, shellfishes). The different results are presented in tables. (N.C.)

  16. Annual analyses of dosimetric impact assessment of the reprocessing plant on the La Hague French site: an example of citizen expertise based on a pluralistic dialogue: (2003 to 2007)

    International Nuclear Information System (INIS)

    The operator (Areva NC) of the La Hague reprocessing plant publishes annual environmental monitoring reports. Those reports firstly provide annual reporting of all the environmental controls and monitoring results and, secondly, present doses received by various groups of the neighbouring population from industrial activity during the elapsed year. French authorities request a pluralistic expert assessment group, the Nord Cotentin Radioecology Group (GRNC), to give an advice on the dose estimates made by the operator. The detail of each GRNC's analysis has to be presented to the La Hague local information commission (CSPI). (author)

  17. Near-field krypton-85 measurements in stable meteorological conditions around the AREVA NC La Hague reprocessing plant: estimation of atmospheric transfer coefficients

    International Nuclear Information System (INIS)

    The aim of this work was to study the near-field dispersion of 85Kr around the nuclear fuel reprocessing plant at La Hague (AREVA NC La Hague – France) under stable meteorological conditions. Twenty-two 85Kr night-time experimental campaigns were carried out at distances of up to 4 km from the release source. Although the operational Gaussian models predict for these meteorological conditions a distance to plume touchdown of several kilometers, we almost systematically observed a marked ground signal at distances of 0.5–4 km. The calculated atmospheric transfer coefficients (ATC) show values (1) higher than those observed under neutral conditions, (2) much higher than those proposed by the operational models, and (3) higher than those used in the impact assessments. - Highlights: • Measurements of 85Kr in air around reprocessing plant. • Measurement in stable meteorological conditions. • Determination of Atmospheric Transfer Coefficients (ATC). • Comparison with operational models. • ATC in stable conditions are higher than data from models

  18. COGEMA experience on retrieving and conditioning solid rad waste waste previously stored in pits. - the La Hague north-west pit case-

    International Nuclear Information System (INIS)

    Short lived, low and medium level waste called technological waste produced by the La Hague Reprocessing Plant have been stored in the La Hague North-West concrete-lined pits until implementation at *ANDRA's Centre de Stockage della Manche (CSM). COGEMA decided to retrieve and condition 11,000 m3 of humid solid rad waste, stored in bulk in pits. On account of the variety of rad waste kinds, retrieving and conditioning operations represented real challenge. One goal of these operations was to ensure that the work was performed in complete safety towards environment with optimum containment and with the best radiation protection for the personnel involved. COGEMA decided to split the work into two phases. The feedback from the first phase was very helpful to the second phase. This report describes the experience gained from February 1990 to December 1998, taking into account rad waste and integrated dose rate results conditioning such waste. The procedures and means used and improved by COGEMA to comply with ANDRA's storage standards and the ever-decreasing financial costs generated by the workers, allowed to retrieve and condition 11,000 m3 of old solid rad waste with competitive costs and in complete safety and protection of the environment. *ANDRA: National Rad waste Management Agency

  19. Year 2006. GRNC's appreciation of the dose estimates presented in the annual environmental monitoring report of Areva-NC La Hague facility. Forth GRNC viewpoint. Detailed report

    International Nuclear Information System (INIS)

    The 'Groupe Radioecologie Nord Cotentin' (GRNC) has carried out a very thorough evaluation of the assessment of doses due to discharges from the Cap de la Hague nuclear site carried out by Areva NC, the site operators. The group has looked at all aspects of the assessment methods and data to ensure that they agree with the results presented in the 2006 annual environmental report of the operator. The computer tool, ACADIE, developed to assess the doses, has been used by the GRNC members to carry out their own calculations. This document comprises the detailed report of the GRNC and its synthesis. The detailed report includes: 1 - a critical analysis of the 2006 source term; a note about the uranium content in liquid effluents; the data transmitted by Areva NC (status of atmospheric effluents, status of liquid effluents at sea, fuel data); the data transmitted by the IRSN - the French institute of radiation protection and nuclear safety (status of the radioactive effluents of Areva La Hague facility); the history of liquid and gaseous effluents between 1966 and 2006; 2 - detailed comparison between model and 2006 measurements; critical analysis of 14C and tritium data available for the Nord Cotentin and the English Channel area; 3 - detail of the 2006 efficient dose calculations; presentation of the environmental dispersion of tritium and of its effects on living organisms. (J.S.)

  20. Evaluation of carbon-14 (C{sup 14}) levels of terrestrial and marine food products of the environment of the site of Cogema La Hague; Evaluation des niveaux de carbone-14 ({sup 14}C) des denrees alimentaires terrestres et marines de l'environnement du site de COGEMA - La Hague

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-04-15

    This evaluation has for object to inform about the levels in carbon 14 in the environment of the factories of La Hague. Two sectors were differentiated on one hand the terrestrial environment, and on the other hand the marine environment. The investigations concerned first and foremost food products stemming as the vegetable culture (vegetables) or individual breeding (milk, eggs) but also foodstuffs stemming from the local agriculture (cereal). In touch with the second sector, the marine environment, the sampling concerned the accessible products of the sea by all and those locally marketed (fishes, molluscs, shellfishes). The different results are presented in tables. (N.C.)

  1. Preliminary study of the 129I distribution in environment of La Hague reprocessing plant with the help of a terrestrial moss: Homalotecium sericeum. Study report

    International Nuclear Information System (INIS)

    The preliminary study of the 129I distribution has allowed to underline the limits of use of a Homalotecium sericeum type terrestrial moss as biological indicator. However, this preliminary study allowed all the same to give a spatial distribution of this radioelement around La Hague reprocessing plant (source term) that underlines the existence of four geographic areas in function of collected activities. The levels are generally under 99 Bq/kg dry. It is recommended to improve the knowledge that we can have of transfers and quantity of iodine 129 from the marine environment to the terrestrial environment, but also, the one that we can have of factors able to modify the spatial distribution of this radionuclide. (N.C.)

  2. Year 2004. GRNC's appreciation of the dose estimates presented in the annual environmental monitoring report of Cogema-La-Hague facility. Second GRNC viewpoint. Detailed report

    International Nuclear Information System (INIS)

    The 'Groupe Radioecologie Nord Cotentin' (GRNC) has carried out a very thorough evaluation of the assessment of doses due to discharges from the Cap de la Hague nuclear site carried out by COGEMA, the site operators. The group has looked at all aspects of the assessment methods and data to ensure that they agree with the results presented in the 2004 annual environmental report of the operator. The computer tool, ACADIE, developed to assess the doses, has been used by the GRNC members to carry out their own calculations. This document comprises the detailed report of the GRNC and its synthesis. The detailed report includes: 1 - critical analysis of the 2004 source term, the data transmitted by Cogema (status of atmospheric effluents, status of liquid effluents at sea, fuel data), the history of liquid and gaseous effluents between 1966 and 2004; 2 - detailed comparison between model and 2004 measurements; 3 - detail of the 2004 efficient dose calculations. (J.S.)

  3. Sobre la presencia de cactáceas naturalizadas en la costa meridional de Cataluña

    Directory of Open Access Journals (Sweden)

    Sanz-Elorza, Mario

    2004-06-01

    Full Text Available The authors report on the finding of eight new alien cacti naturalised in the Baix Camp (Tarragona. Three of these are new records for Europe, two are new records for Spain and one is a first record for Tarragona province. Two further species are not new floristic records however some revision of their status in Catalonia is required. Discussed is the extensive use of alien plant species in garden design in the area and the mildness of the local climatic conditions which has resulted in the greatest accumulation of naturalised cacti in Europe.En una riera de la comarca del Baix Camp (Tarragona hemos encontrado ocho especies de cactáceas alóctonas naturalizadas. De ellas, tres son nuevas para Europa, dos nuevas para España, una nueva para la provincia de Tarragona y, finalmente, otras dos sin ser novedad florística requieren aclaraciones en lo concerniente a su estatus en Cataluña. Este hallazgo representa la mayor biodiversidad de cactáceas citada hasta el momento para toda Cataluña, para toda la Península Ibérica e incluso para toda Europa. La introducción de especies exóticas en general y de cactáceas en particular se ve favorecida en esta comarca de la costa mediterránea por el desarrollo de una jardinería basada casi exclusivamente en elementos foráneos y en la existencia de una climatología muy favorable.

  4. The Hague Judgments Convention

    DEFF Research Database (Denmark)

    Nielsen, Peter Arnt

    2011-01-01

    The Hague Judgments Convention of 2005 is the first global convention on international jurisdiction and recognition and enforcement of judgments in civil and commercial matters. The author explains the political and legal background of the Convention, its content and certain crucial issues during...... the negotiations of it. Finally, the author discusses the perspectives for international trade given that, in 2009, the USA and the European Union signed the Convention....

  5. Effects of the purification techniques applied to industrial wastes on the chemical behaviour of ruthenium 106 in the marine environment. The case of La Hague reprocessing plant releases

    International Nuclear Information System (INIS)

    Since nuclear fuel reprocessing started at the La Hague plant in 1966, the efficiency of the purification techniques applied to radioactive wastes has been improved by a factor of 600. The chemical behaviour of 106Ru observed in the liquid releases into the sea and at two coastal sites near the outlet, shows time variations related to the evolution of the reprocessing techniques used. The ''wet chemical method'' based on 106Ru coprecipitation with cobalt sulphide has fulfilled the objectives of environmental protection and the requirements of industrial productivity. As a consequence, 106Ru behaves like the weakly reactive complexes formed during the nitric acid dissolution stage of the process. Since 1989, vitrification of the effluents mainly affected by these complexes and the optimization of the wet method have contributed to the reduction of 106Ru liquid releases into the sea. At the same time, the radionuclide chemical non-reactivity has been attenuated. Measurements of 106Ru activity carried out in the seaweed Fucus serratus show that the availability of nitrosylruthenium in seawater is closely related to hydrolysis of the complexes. Hydrolysis products are the main source of the chemical species available for exchange with the seaweed, its concentration factor being estimated at 500 ± 350. (authors). 26 refs., 10 tabs., 6 figs

  6. Year 2003. GRNC's appreciation of the dose estimates presented in the annual environmental monitoring report of Cogema-La-Hague facility. Detailed reports

    International Nuclear Information System (INIS)

    The 'Groupe Radioecologie Nord Cotentin' (GRNC) has carried out a very thorough evaluation of the assessment of doses due to discharges from the Cap de la Hague nuclear site carried out by COGEMA, the site operators. The group has looked at all aspects of the assessment methods and data to ensure that they agree with the results presented in the 2003 annual environmental report of the operator. The computer tool, ACADIE, developed to assess the doses, has been used by the GRNC members to carry out their own calculations. This document comprises the detailed report of the GRNC and its synthesis. The detailed report includes: 1 - critical analysis of the 2003 source term, the data transmitted by Cogema (presentation of the July 6, 2005 meeting, status of atmospheric effluents, status of liquid effluents at sea, fuel data), the history of liquid and gaseous effluents between 1966 and 2003; 2 - detailed comparison between model and measurements; 3 - ACADIE users manual, doses calculated by the GRNC during its third mission (year 2003). (J.S.)

  7. Year 2005. GRNC's appreciation of the dose estimates presented in the annual environmental monitoring report of Areva-NC La Hague facility. Third GRNC viewpoint. Detailed report

    International Nuclear Information System (INIS)

    The 'Groupe Radioecologie Nord Cotentin' (GRNC) has carried out a very thorough evaluation of the assessment of doses due to discharges from the Cap de la Hague nuclear site carried out by Areva NC, the site operators. The group has looked at all aspects of the assessment methods and data to ensure that they agree with the results presented in the 2005 annual environmental report of the operator. The computer tool, ACADIE, developed to assess the doses, has been used by the GRNC members to carry out their own calculations. This document comprises the detailed report of the GRNC and its synthesis. The detailed report includes: 1 - critical analysis of the 2005 source term, the data transmitted by Areva NC (status of atmospheric effluents, status of liquid effluents at sea, fuel data, presentation of the work progress of the Areva NC working group), the history of liquid and gaseous effluents between 1966 and 2005; 2 - detailed comparison between model and 2005 measurements; 3 - detail of the 2005 efficient dose calculations. (J.S.)

  8. Evaluation of the nuclear installations safety of the CEA in 1998; Le bilan de la surete des installations nucleaires du CEA en 1998

    Energy Technology Data Exchange (ETDEWEB)

    Laverie, M. [CEA, Dir. de la Surete Nucleaire et de la Qualite, 75 - Paris (France)

    1999-09-01

    Michel Laverie, Director of the nuclear safety and quality at the Cea, took stoke of the CEA nuclear installations in 1998. After a recall of the nuclear safety policy and organization, the author presents the risks factors bound to the CEA activities as the dismantling, the wastes and the human factors. A last part is devoted to the list of the accidents occurred during 1998 in the nuclear installations. Tables and statistics illustrate this analysis. (A.L.B.)

  9. Study of the {sup 60}Co speciation in the aqueous radioactive waste of the la Hague nuclear reprocessing plant; environmental behaviour after discharges in the waters of the channel; Etude de la speciation du {sup 60}Co dans les effluents de l'usine de retraitement de combustibles irradies de la Hague; devenir apres rejet dans les eaux de la Manche

    Energy Technology Data Exchange (ETDEWEB)

    Gaudaire, J.M

    1999-07-01

    {sup 60}Co is produced as an activation product and is present in the low-level aqueous radioactive waste released from the La Hague plant. At present, the concentration in the sea (non filtered at 0.45 {mu}m) at the Goury site are close to or even below, the detection limit: 0.2 mBq.l{sup -1}. The {sup 60}Co speciation depends on the type of effluent considered: in the effluent A ('active'), the cobalt is in the form of a stable trivalent complex; in the effluent V (to be checked), the cobalt is in majority (50% of the activity release) in the form of particles (>0.45 {mu}m), and then in the form of two soluble species: ionic divalent (Co{sup 2+}) and some stable complexes. The evolution of the reprocessing techniques used does not affect the speciation. So, since the nuclear reprocessing plant started at the La Hague plant in 1966, the chemical species discharged in the sea shows time variation related to the evolution of the type of effluent discharged. Thus, since 1994, the particles of cobalt are the main species discharged in the Channel (the V effluents represent more than 85% of the total {sup 60}Co activity released). The effect of instantaneous dilution into the marine conditions involving a variation of pH, oxido-reduction, ionic strength, a gradient of salinity, does not interfere with the evolution of the chemical species discharged. Nevertheless, during the discharge of the V effluent, the main constituents of the sea water (Mg{sup 2+} and Ca{sup 2+}) go through a precipitation. This comes with the coprecipitation of the ion Co{sup 2+} and with the particles of cobalt (complexes are not affected), and it can be responsible for an increase in the concentration in the particles. The chemical behaviour of the cobalt in the Channel is different from those of conservative element such as antimony. The ionic cobalt and the particles have a small dispersion in the water (cobalt has a very high particle/dissolved distribution factor, it is a non

  10. Study of the 60Co speciation in the aqueous radioactive waste of the la Hague nuclear reprocessing plant; environmental behaviour after discharges in the waters of the channel

    International Nuclear Information System (INIS)

    60Co is produced as an activation product and is present in the low-level aqueous radioactive waste released from the La Hague plant. At present, the concentration in the sea (non filtered at 0.45 μm) at the Goury site are close to or even below, the detection limit: 0.2 mBq.l-1. The 60Co speciation depends on the type of effluent considered: in the effluent A ('active'), the cobalt is in the form of a stable trivalent complex; in the effluent V (to be checked), the cobalt is in majority (50% of the activity release) in the form of particles (>0.45 μm), and then in the form of two soluble species: ionic divalent (Co2+) and some stable complexes. The evolution of the reprocessing techniques used does not affect the speciation. So, since the nuclear reprocessing plant started at the La Hague plant in 1966, the chemical species discharged in the sea shows time variation related to the evolution of the type of effluent discharged. Thus, since 1994, the particles of cobalt are the main species discharged in the Channel (the V effluents represent more than 85% of the total 60Co activity released). The effect of instantaneous dilution into the marine conditions involving a variation of pH, oxido-reduction, ionic strength, a gradient of salinity, does not interfere with the evolution of the chemical species discharged. Nevertheless, during the discharge of the V effluent, the main constituents of the sea water (Mg2+ and Ca2+) go through a precipitation. This comes with the coprecipitation of the ion Co2+ and with the particles of cobalt (complexes are not affected), and it can be responsible for an increase in the concentration in the particles. The chemical behaviour of the cobalt in the Channel is different from those of conservative element such as antimony. The ionic cobalt and the particles have a small dispersion in the water (cobalt has a very high particle/dissolved distribution factor, it is a non-conservative radionuclide). This sedimentary stock can involve a

  11. Seance of the 11. december 2002 of the special and permanent commission of information nearby the establishment of La Hague. Audition de Mycle Schneider, Director of Ise-Paris

    International Nuclear Information System (INIS)

    The intervention of Mycle Schneider leaned on numerous updated transparencies (graphs, illustrations) gathered according to the principal tackled themes. The tables and graphs devoted to the doses issued from releases of reprocessing plants show a revised version of collective doses estimations. The different subjects are: the world electronuclear park, the situation of nuclear matters, the exploitation of La Hague facility, the release in environment of reprocessing plants, the individual land collective radiation doses induced by releases, the risk of a plane fall and other safety problems. (N.C.)

  12. Decree No 90-734 of 9 August 1990 publishing the Agreement by an Exchange of Notes between the Government of the French Republic and the Government of the Federal Republic of Germany on the reprocessing of German nuclear power plant spent fuel elements at La Hague, signed in Bonn on 25 April 1990

    International Nuclear Information System (INIS)

    The Agreement entered into force on the date of its signature and provides for the reprocessing of German spent fuel elements in the French reprocessing plant at La Hague and to this effect, refers to two model contracts established jointly. It specifies that both Governments will apply the London Club Guidelines for nuclear transfers, in particular as regards physical protection and controls on retransfers. It also states that the La Hague plant is regularly inspected by the IAEA in accordance with the Agreement between France, the European Communities and the IAEA

  13. Rapport d'étude : La perception des risques majeurs par les riverains du CEA de Cadarache

    OpenAIRE

    Lopez, Alexia; Régner, Isabelle; Schleyer-Lindenmann, Alexandra

    2015-01-01

    Ce rapport d'étude vient répondre aux interrogations de son commanditaire, la CLI (Commission Local d'Information) du CEA (Commissariat à l'énergie Atomique) de Cadarache. Il s'organise en trois partie : une première partie établit un état des lieux des connaissances des risques majeurs par les habitants. Les risques majeurs officiellement recensés sont : le risque feu de forêt, le risque inondation, le risque sismique, le risque de mouvement de terrain, le risque de rupture de barrage, et le...

  14. Report from the production and exchanges commission about the resolution proposal (no 2937) of Mr Noel Mamere which aims at creating an inquiry commission relative to the existence and storage of ultimate nuclear wastes at the Hague plant, in violation of the law from December 30, 1991, and under the liabilities of Cogema; Rapport fait au nom de la commission de la production et des echanges sur la proposition de resolution (no 2937) de M. Noel Mamere tendant a creer une commission d'enquete relative a l'existence et au stockage de dechets nucleaires non retraitables a l'usine de la Hague, en violation de la loi du 30 decembre 1991, et sur les responsabilites de la Cogema en la matiere

    Energy Technology Data Exchange (ETDEWEB)

    Bono, M. [Assemblee Nationale, 75 - Paris (France)

    2001-04-01

    This document presents the motives of the French production and exchanges commission for the rejection of the proposal from the French 'green' deputy Noel Mamere about the creation of an inquiry commission which would aim at verifying the illegal storage of irradiated MOX fuels from German nuclear facilities at the Cogema La Hague plant. (J.S.)

  15. Overview of CEA research in the field of radionuclides migration; Syntheses des recherches menees par le CEA sur la migration des radionucleides

    Energy Technology Data Exchange (ETDEWEB)

    Poinssot, Ch.; Trotignon, L.; Tevissen, E

    2006-07-01

    This report presents a synthetic status of the researches conducted within the Nuclear Energy Division (CEA/DEN) in the field of radionuclides migration in three specific areas which have been chosen for their representativeness and potential impact: the migration of RN in PWR reactors, the migration of RN from a deep geological repository and the migration processes in the surface environments. In addition, some status is given about more generic research which is conducted in the field of RN speciation in the aqueous phase and at the interfaces and regarding chemistry / transport couplings. Additional information about the human and technical means involved in these fields of research in CEA/DEN is finally given in the Appendix. (authors)

  16. The evaluation of the nuclear facilities safety at the CEA from 1999 to 2001; Le bilan de la surete des installations nucleaires du CEA du 1999 a 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    The aim of this document is the presentation of an evaluation of the problems and the safety methods in the concerned period. The first chapter presents the nuclear safety in the CEA. The second chapter is devoted to the organization and the quality for the safety: liabilities, audits, relations with the safety authorities and with the public. The chapters three and four deal respectively with the methodological and technical abilities supporting the exploitation teams and with the nuclear safety projects. The last chapter presents the experiments and events from 1999 to 2001. (A.L.B.)

  17. Continuously tritium monitoring of the pipe of liquid effluents at the Cea Cadarache; Controle en continu du tritium de la conduite des effluents liquides du CEA Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    Pira, Y

    2004-07-01

    This report is oriented toward the radiation protection of environment that is an essential component of radiation protection. It is necessary to detect any solid, liquid or gaseous abnormal release and to find its origin. The present study bears on a detection instrument in continuously to find tritium in liquid effluents of the Cea Cadarache. After having study the functioning principle of this device, an evaluation of its performances has been realised ( back noise, yield, detection limit) and to a checking in real conditions of utilization. (N.C.)

  18. CEA decommissioning strategy and program for nuclear facilities

    International Nuclear Information System (INIS)

    The CEA's experience of the decommissioning of nuclear facilities goes back many decades and relates to many installations of very different types. The first substantial operations began in the sixties and seventies, and included, for instance, the first plutonium plant at Fontenay-aux-Roses (total decommissioning) and a number of small research reactors and critical mock-ups such as Cesar and Peggy at Cadarache, and Minerve at Fontenay-aux-Roses. Some twenty facilities were dealt with by 2000, corresponding to around half of all the nuclear facilities permanently closed, beginning with the decommissioning of facility AT1 at La Hague, the pilot plant used by the CEA in the seventies for the reprocessing of spent fuel from fast neutron reactors in March 2001 and ending with the demolition of the G1 stack at Marcoule, on 19 July this year. During the nineties, decommissioning was scaled back and few of the operations in progress were completed. The end of the decade saw a slowdown which was a consequence of financial difficulties, as the CEA had not yet set aside sufficient funds to cover the work, even though, between 1993 and 1999, part of the necessary resources had been provided under an agreement with the industrial partners EDF and Cogema. At the present time, the situation is rapidly improving both as concerns organisational and financial issues for the CEA and as concerns the regulations and the management of waste for all the organisations involved. First of all, for the different problems associated with radioactive clean-up faced by its research centres, the efforts made by the CEA in the field of organisation and planning since the beginning of the nineties have led to the drawing up of an overall multi-year plan referred to as the 'CEA civil centre radioactive clean-up plan' and the appointment of the Legacy and Clean-up Directorate to act as the client and be in charge of application of the plan relating not only to decommissioning of the nuclear

  19. Una sapotácea nueva en la flora de colombia

    OpenAIRE

    2012-01-01

    En este trabajo se describe una nueva especie de Pouteria, a cuyos frutos los campesinos de la región de Albán y Sasaima, en el Departamento de Cundinamarca, atribuyen propiedades anticonvulsivas en el tratamiento de la epilepsia. Flora Medicinal de Colombia, II tomo, pág. 371; H. García-Barriga, 1975.La región donde crece la especie fue hasta hace algunos años una zona boscosa permanentemente nublada, pero en la actualidad se ve notablemente degradada por efecto de la tala, debido a que la e...

  20. Una histórica melastomatácea, nueva en la flora de colombia

    OpenAIRE

    2012-01-01

    EI Instituto de Ciencias Naturales de la Universidad Nacional ha procurado seguir con cariño y devoción las huellas que dejó, hace cerca de dos siglos, la gloriosa Real Expedición Botánica del Nuevo Reina de Granada (hoy Colombia), repitiendo sus excursiones, buscando sus plantas y eventualmente reivindicando para la ciencia nacional descubrimientos que ella no logró divulgar en su tiempo.  En años pasados una comisión de dos miembros del Instituto recorrió con éxito halagador, la región de L...

  1. Catálogo de las Melastomatáceas de la comunidad Curare, Guayana colombiana

    Directory of Open Access Journals (Sweden)

    Betancur Julio

    2006-06-01

    Full Text Available Se presenta un catálogo de las especies de Melastomataceae encontradas en el territorio de la comunidad indígena Curare, departamento de Amazonas, Colombia, área que hace parte de la región fitogeográfica de
    la Guayana, provincia Guayana occidental. El catálogo contiene una descripción morfológica de la familia y
    una lista anotada de las especies, la cual presenta para cada especie información sobre el hábito, el hábitat y la distribución geográfica. Se encontraron 27 especies y diez géneros, siendo los más ricos en especies Miconia (ocho, Clidemia (cinco y Tococa (tres. La mayor parte de las especies (17 presenta una distribución amazónica, mientras las restantes se encuentran ampliamente distribuidas en el neotrópico. La unidad fisiográfica con mayor riqueza de especies (18 fue el bosque de tierra firme, seguido por el bosque inundable (seis y el “cananguchal” (cuatro; es de resaltar el hecho al ausencia de la familia en las formaciones de caatingas.

  2. Las ericáceas de la vertiente pacífica de Nariño, Colombia

    Directory of Open Access Journals (Sweden)

    Betancur Julio

    2005-07-01

    (Cavendishia oligantha, Diogenesia alstoniana y Vaccinium sp. nov. y las seis restantes son compartidas con la región  limítrofe del norte del Ecuador. Tres especies (Cavendishia callista, Disterigma pseudokillipiella y Macleania smithiana fueron exclusivas de la llanura del Pacífico (por debajo de 500 m de altitud, 31 especies de la región Andina (por encima de 500 m de altitud y 19 se compartieron entre ambas regiones.
    La mayor riqueza de especies y endemismos se presentó entre 1.000 y 1.600 m de altitud, con 45 especies. Los resultados obtenidos muestran que la vertiente pacífica del departamento de Nariño, Colombia, es la región de América con mayor número de especies de ericáceas por unidad de área.

  3. 22 CFR 97.2 - Application for a Hague Adoption Certificate or a Hague Custody Declaration (outgoing Convention...

    Science.gov (United States)

    2010-04-01

    ... a Hague Custody Declaration (outgoing Convention case). 97.2 Section 97.2 Foreign Relations... HAGUE CONVENTION ADOPTION CASES § 97.2 Application for a Hague Adoption Certificate or a Hague Custody Declaration (outgoing Convention case). (a) Once the Convention has entered into force for the United...

  4. Evaluación de la actividad repelente de aceites esenciales de plantas Piperáceas del departamento de Chocó, Colombia

    OpenAIRE

    BE Jaramillo-Colorado; E Duarte-Restrepo; Nayive Pino-Benítez

    2015-01-01

    El objetivo de este trabajo fu e determinar la composición química volátil del aceite esencial de varias especies de Piper áceas ( Piper dilatatum, Piper aduncum, Piper divaricatum, Piper sp, Piper sanctifelicis) y la actividad repelente de ellos contra el gorgojo de granos almacenados Tribolium castaneum Herbst. Los aceites esenciales se obtuvieron por hidrodestilación, la separación e identificación de los component es volátiles se realizó por cromatografía de gase...

  5. Caldera La Peligrosa (47º15´S, 71°40´O: un evento clave en la Provincia Silícea Chon Aike

    Directory of Open Access Journals (Sweden)

    Patricia Sruoga

    2010-05-01

    Full Text Available En el área ubicada entre el lago Ghío y la sierra Colorada, en la Cordillera Patagónica Austral, aflora una secuencia piroclástico- lávica de carácter proximal correspondiente al Complejo El Quemado, de edad jurásica tardía. A partir del análisis integrado de litofacies y estructuras se llevó a cabo la reconstrucción de la arquitectura volcánica. Se han reconocido cuatro litofacies ignimbríticas y una litofacies lávico-hipabisal de composición riolítica, cuyo emplazamiento estuvo controlado por un sistema de fallas transtensionales de orientación NNO predominante. Se propone un modelo de evolución de la caldera La Peligrosa en tres etapas:1 pre-colapso, durante la cual se define una zona dilatante propicia para la formación de la caldera, con incipiente fallamiento en bloques, 2 colapso, cuando ocurre el emplazamiento de potentes ignimbritas cristalinas y megabrechas en una cubeta de subsidencia progresiva, controlada por un régimen transtensional con dirección de extensión NE y 3 post-colapso, durante la cual se produce el derrame de lavas junto con la intrusión de cuerpos dómicos, bajo condiciones de extensión oblicua con dirección de extensión NO. El pasaje de un ambiente transtensional a condiciones de extensión oblicua acompañó las últimas etapas del desarrollo de la caldera representando un notable cambio en las condiciones de la deformación en tiempos jurásicos. La formación y desarrollo de la caldera La Peligrosa puede ser considerada como un evento clave para entender los mecanismos eruptivos del vasto volcanismo ignimbrítico de la Provincia Silícea Chon Aike.

  6. Las ciperáceas (Cyperaceae) de la Estación Biológica La Selva, Costa Rica

    OpenAIRE

    Jorge Gómez-Laurito

    2009-01-01

    La familia Cyperaceae es cosmopolita e incluye unos 115 géneros y 3600 especies. Costa Rica tiene 25 géneros y 210 especies. Aquí presento claves y descripciones para las 34 especies (10 géneros) que ocurren en la Estación Biológica La Selva, Costa Rica. El género Cyperus está representado por 12 especies, seguido por Rhynchospora (6), Scleria (5), Calyptocarya (2), Eleocharis (2), Kyllinga (2), Mapania (2), Hypolytrum (1) y Lipocarpha (1). Oxycaryum cubense (Poepp & Kunth) Palla, ha sido col...

  7. 22 CFR 97.4 - Issuance of a Hague Adoption Certificate or a Hague Custody Declaration (outgoing Convention case).

    Science.gov (United States)

    2010-04-01

    ... Hague Custody Declaration (outgoing Convention case). 97.4 Section 97.4 Foreign Relations DEPARTMENT OF... CONVENTION ADOPTION CASES § 97.4 Issuance of a Hague Adoption Certificate or a Hague Custody Declaration (outgoing Convention case). (a) Once the Convention has entered into force for the United States,...

  8. Nuevas tecnologías desarrolladas para el aprovechamiento de las cactáceas en la elaboración de alimentos. Componentes funcionales y propiedades antioxidantes

    Directory of Open Access Journals (Sweden)

    Mónica Azucena Nazareno

    2011-06-01

    Full Text Available Las cactáceas han sido consideradas por nuestros ancestros y contemporáneos una fuente de alimento y también de medicinas. La mayoría presenta frutos y cladodios comestibles que a su vez pueden ser procesados a una amplia variedad de nuevos productos. Se ha demostrado que su consumo ofrece beneficios nutricionales y promueve la salud, y debido a esto existe un marcado interés en el desarrollo de nuevas tecnologías y la adquisición de nuevos conocimientos sobre su naturaleza química y propiedades para un mejor aprovechamiento, lo que genera nuevos estudios. En tal sentido, en este trabajo se recopiló información de la literatura que fue revisada, con el propósito de aportar una visión general sobre las nuevas tecnologías desarrolladas para el aprovechamiento de los cactus en la elaboración de alimentos con énfasis en sus componentes bioactivos y propiedades antioxidantes. Se concluye que un amplio espectro de nuevas tecnologías está siendo explorado a fin de obtener alimentos cuya función no sea solamente un aporte nutricional sino también que represente un beneficio para la salud de los consumidores.

  9. Nuevas tecnologías desarrolladas para el aprovechamiento de las cactáceas en la elaboración de alimentos. Componentes funcionales y propiedades antioxidantes

    Directory of Open Access Journals (Sweden)

    Mónica Azucena Nazareno

    2011-01-01

    Full Text Available Las cactáceas han sido consideradas por nuestros ancestros y contemporáneos una fuente de alimento y también de medicinas. La mayoría presenta frutos y cladodios comestibles que a su vez pueden ser procesados a una amplia variedad de nuevos productos. Se ha demostrado que su consumo ofrece beneficios nutricionales y promueve la salud, y debido a esto existe un marcado interés en el desarrollo de nuevas tecnologías y la adquisición de nuevos conocimientos sobre su naturaleza química y propiedades para un mejor aprovechamiento, lo que genera nuevos estudios. En tal sentido, en este trabajo se recopiló información de la literatura que fue revisada, con el propósito de aportar una visión general sobre las nuevas tecnologías desarrolladas para el aprovechamiento de los cactus en la elaboración de alimentos con énfasis en sus componentes bioactivos y propiedades antioxidantes. Se concluye que un amplio espectro de nuevas tecnologías está siendo explorado a fin de obtener alimentos cuya función no sea solamente un aporte nutricional sino también que represente un beneficio para la salud de los consumidores.

  10. The great Cea actors

    International Nuclear Information System (INIS)

    With the Claude Frejacques life it is a Cea passage that we find. He began the studies on uranium isotope separation. He developed and saw to a successful conclusion these researches at Cea during twenty five years and extended his sphere of operations to the whole fuel cycle, from upstream to downstream. Director of research at the Cea, he was also D.G.R.S.T. director and during eight years President of the C.N.R.S. (N.C.)

  11. Variación espacial en la polinización y el éxito reproductivo de una herbácea endémica: implicaciones para su conservación

    OpenAIRE

    Fernández Carmona, Juande D.

    2014-01-01

    Estudiar la dinámica poblacional de las especies vegetales y el efecto de los distintos factores bióticos y abióticos en su reproducción es esencial para conocer y entender la biología reproductiva de las plantas. Este conocimiento tiene especial relevancia desde el punto de vista de la conservación cuando se centra en especies endémicas y/o amenazadas. En esta tesis doctoral hemos estudiado en profundidad la reproducción de Erysimum popovii, una herbácea endémica del sureste de la Península ...

  12. CEA Annual report 2007

    International Nuclear Information System (INIS)

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities for the year 2007 in these three main areas: science and technology working for nuclear deterrence and global security, the energies without greenhouse effect gases emission against the climatic change, researches in the information sciences and technologies for a better communication and health. The CEA safety, organization, communication and international relations are also presented. (A.L.B.)

  13. Las ericáceas de la vertiente pacífica de nariño, colombia

    OpenAIRE

    Betancur Julio; Salinas Nelson R.

    2011-01-01

    Se realizó el tratamiento taxonómico de la familia Ericaceae para la vertiente pacífica del departamento de Nariño, Colombia. El área de estudio abarca toda la llanura del pacífico y la vertiente pacífica de la cordillera de los Andes, hasta los 2.000 m de altitud, de dicho departamento. Los registros de las especies se obtuvieron mediante trabajo de campo, revisión de literatura y el estudio de las colecciones depositadas en los  herbarios CAUP, COL, HUA, PSO, QCA y QCNE. En el tratamiento t...

  14. Estimation of the risk of radiation-induced leukaemia among young people in the vicinity of the La Hague reprocessing plant. Results from the nord-cotentin radioecological study

    International Nuclear Information System (INIS)

    A radioecological study has been performed around the La-Hague nuclear reprocessing plant (Nord-Cotentin, France). The Working Group included nuclear operators, authorities, international experts and members of environmental organisations and was supported by IPSN. The study aimed to reconstruct radiation doses received by members of the public aged 0 to 24 years and living in the area, with a view to estimate the associated risk of leukaemia between 1978 and 1996. The assessment involved three steps: 1. reconstruction of a cohort of people aged 0 to 24 years, using local birth rates for the years 1954 to 1996 and taking into account the additional migrations of young people in the area. 2. estimation of doses to the red bone marrow received from all source of radiation (natural, medical, local nuclear industries and Chernobyl and weapons testing). Concentrations of radionuclides in the environment were estimated with a combination of two approaches: the modelling of the transfer of the releases in the environment and the use of environmental measurements. The dose computation takes into account the life style of the local population. ICRP dose coefficients to the red bone marrow were used. 3. derivation of leukaemia risk from a dose response model recommended by the UNSCEAR committee. The reconstructed population includes 6656 people born between 1954 and 1996, who inhabited the study area for at least one year between 1978 and 1996 before the age of 25. The number of person-years between 1978 and 1996 is 69308. The total collective dose to the red bone marrow due to local nuclear installations is 0.5 man.Sv. For the sake of comparison, the collective dose due to all sources of exposure is 241 man.Sv: The estimated number of leukaemia due to all exposure sources is 0.835. 74% are due to natural exposures, 24% to medical ones and 2% to the Chemobyl accident and nuclear arm testing. Nuclear facilities of Nord-Cotentin contribute only for 0.1% (between 0.0009 and 0

  15. Volumen y dimensiones como predictores del peso de semilla en especies herbáceas del centro de la Península Ibérica

    Directory of Open Access Journals (Sweden)

    Sánchez, Ana M.

    2001-12-01

    Full Text Available Although seed weight is a key factor in understanding the reproductive biology of plant species, its value is unknown for a large proportion of the herbaceous species in the Mediterranean basin. This paper presents data on seed weight, dimensions and volume for 1 18 herbaceous species in acidic Mediterranean scrub and grassland in the centre of the Iberian Peninsula. This information is used to design predictive models of seed weight using multiple regression models. taking into account the phylogenetic effect. Five groups of models were designed: one using Trifolium species. three. using the families represented by the largest number of species (Catyophyllaceae, Asteraceae and Poaceae; and finally a general model using one species from each of the families present in the sample. The models are rated according to the absorbed variante, their significance in relation to the previous in complexity and the effort required to obtain the data for each one. We also test the validity of seed dimension data taken from literature sources to predict seed weight. The 1-0 seed dimensions are excellent weight predictors in the case of Trifolium (Weight = - 24.55 + 0.10D1 + 3.38D2, r2 = 0.94 and Asteraceae (Weight = - 20.90 + 1.19D1 + 1.67D2, r2 = 0.91 and are quite satisfactory in the case of the general model (Weight = - 16.01 +0.56D1 + 1.6002, r2 = 0.69.El peso de las semillas es un carácter clave para entender la biología reproductiva de las especies vegetales, pero se desconoce su valor para gran parte de las especies herbáceas de la cuenca mediterránea. En este trabajo se exponen datos de peso, dimensiones y volumen de las semillas de 118 especies herbáceas características del matorral y pastizal acidófilos mediterráneos del centro de la Península Ibérica. Esta información es empleada para elaborar modelos predictivos del peso a partir de las dimensiones mediante el uso de modelos de regresión lineal múltiple, teniendo en cuenta el efecto

  16. CEA financial report 2007

    International Nuclear Information System (INIS)

    This document provides financial data on the CEA for the year 2007. The management report (budget, resources, expenditures) and the accounting are detailed. The main management events of the year 2007 are presented. (A.L.B.)

  17. The Hague Convention: Pros, Cons and Potential

    OpenAIRE

    Bartholet, Elizabeth

    2013-01-01

    This revised speech describes the Hague Convention’s significance both in terms of the law on the books and the law on the ground. The Convention’s language advanced child rights in international law to the protection of international adoptive homes. However the Convention has been misinterpreted and misused so that it has actually functioned to date to destroy children’s opportunities for adoption. The future remains open for the Convention to serve as it was intended by the framers to exp...

  18. Evaluación de la actividad repelente de aceites esenciales de plantas Piperáceas del departamento de Chocó, Colombia

    Directory of Open Access Journals (Sweden)

    BE Jaramillo-Colorado

    2015-01-01

    Full Text Available El objetivo de este trabajo fu e determinar la composición química volátil del aceite esencial de varias especies de Piper áceas ( Piper dilatatum, Piper aduncum, Piper divaricatum, Piper sp, Piper sanctifelicis y la actividad repelente de ellos contra el gorgojo de granos almacenados Tribolium castaneum Herbst. Los aceites esenciales se obtuvieron por hidrodestilación, la separación e identificación de los component es volátiles se realizó por cromatografía de gases acoplada a espectrometría de masas y par a la evaluación de la activ idad repelente se empleó el método de áre a de preferencia. Los compuestos m ayoritarios encontrados en Piper dilatatum fueron el apiol 89,0% y trans -cariofileno (3,5%; en Piper divaricatum, eugenol (37,5% y metil eugenol (36,3%; Piper sp,  - gurjuneno (o guaieno (24,9% y elemol (14,2%; Piper sanctifelicis,  -3-careno (35,3% y limoneno (27,1%; Piper aduncum , dilapiol (48,2% y 1,8 cineol (11,4%. Los porcentajes de repelencia de los aceites esenciales a una concentración de 1 μ L/cm 2 , a un tiempo de exposición de 2 horas frente al T. castaneum fueron: Piper aduncum (99%, Piper sp (96%, Piper dilatatum (82%, Piper divaricatum (76%, Piper santifelicis (33%.

  19. Detección del Virus Mosaico Amarillo de la Calabaza Zucchini (ZYMV) y su Coinfección con otros Virus en Cucurbitáceas Cultivadas y Plantas Silvestres en el Valle del Fuerte, Sinaloa, México

    OpenAIRE

    Rubén Félix-Gastélum; Marco Antonio Magallanes-Tapia; Jesús Méndez-Lozano; Hervé Huet; José Ángel Trigueros-Salmerón; Rosa María Longoria-Espinoza

    2007-01-01

    Las enfermedades de origen viral son el principal factor limitante en la producción de cucurbitáceas en el Valle del Fuerte, Sinaloa, México. El objetivo del presente estudio fue detectar al virus mosaico amarillo de la calabaza zucchini (ZYMV), virus mosaico de la sandía (WMV), virus mancha anular del papayo variante sandía (PRSV-W) y virus mosaico del pepino (CMV) mediante ELISA y RT-PCR. En el mes de noviembre predominaron ZYMV con 54.5% de incidencia y la mezcla ZYMV + PRSV-W con 36.4%; e...

  20. Las Gramináceas

    Directory of Open Access Journals (Sweden)

    Robledo Emilio

    1939-08-01

    Full Text Available Las gramináceas son plantas conocidas desde la antigüedad más remota. Tan importantes son las gramináceas desde el punto de vista bromatológico, que los hombres pueden ser clasificados en comedores de trigo, de arroz, de maíz, de mijo, de sorgo, de tocusso, de tef, etc. El área de distribución de las gramíneas es inmensa: se las encuentra desde las orillas del mar y en las aguas dulces, hasta las nieves perpetuas; sólo en las aguas saladas desconocidas. En punto de tamaño, las hay desde unos centímetros hasta nuestra guadua gigantesca, de treinta y más metros de altura. Dicha distribución se halla en relación con el clima, pero también es influida por los hábitos de los pueblos, por la civilización, por el comercio o por otras circunstancias.

  1. CEA 2005 annual report

    International Nuclear Information System (INIS)

    This document is the 2005 activity report of the French atomic energy commission (CEA). The CEA is a main actor of nuclear research, development and innovation and is involved in three main domains: energy, defense/security, and information/health technologies thanks to high quality research works. With a manpower of 15000 researchers and collaborators with internationally acknowledged competences, the CEA is a driving force of industrial innovation and develops partnerships with French and European industries. It also warrants the perenniality of nuclear dissuasion. This report presents these different aspects of the CEA activities: 1 - defense-security: simulation program, opening to the scientific community, nuclear warheads, nuclear propulsion, cleansing of Rhone valley facilities, permanent monitoring of treaties respect, fight against terrorism; 2 - energy: optimization of the industrial park, advances in long lived radioactive wastes management, future nuclear systems, cleansing and dismantling integration, European nuclear energy research, new energy technologies; 3 - information and health technologies: major challenge of micro- and nano-technologies, key role of software technologies and complex systems; 4 - big research facilities opened to the scientific and industrial communities; 5 - scientific status: scientific evaluation process, prices and honors; 6 - programs support: revisited strategic control, confirmed simplification, active employment and training policy, teaching and training, technological valorization, international relations, communication, continuous quality approach, mastery of facilities safety, security, environmental control, a key-year for information systems. A financial report is attached to the document. (J.S.)

  2. Análisis de la variabilidad genética de la colección colombiana de musáceas usando marcadores isoenzimáticos

    Directory of Open Access Journals (Sweden)

    Giraldo Martha C.

    2011-06-01

    Full Text Available La Colección Colombiana de Musãceas (CCM es la ünica a nivel mundial %ue representa un alto valor por ser la %ue posee introducciones andinas de altura (& 1( m.s.n.m.. La caracterización de este germoplasma puede generar valor agregado para su utilización en procesos de selección clonal - para el mejoramiento genético de la especie, mediante el uso de materiales diploides con características transmisibles de importancia. Por esta razón, 33 clones de la CCM conservadas in vitro, fueron evaluadas bio%uimicamente mediante 1 enzimas, de las cuales cuatro 4ueron polimór7cas: glutamato o=aloacetil transaminasa (GOT, a13-esterasa (a13HIJL, pero=idasa (PMQ - dia4orasa (DVWP. La enzima GYL 4ue la mãs discriminante entre grupos genómicos particulares. PMQ, DVWP - a13HIJL permitieron evaluar la variabilidad al interior de cada grupo. Il estudio 4acilita el entendimiento de la estructura genética de los genotipos de plátano y banano cultivados en Colombia. .

  3. Operation of Geothermal Heat System in The Hague, Netherlands

    International Nuclear Information System (INIS)

    Geothermal Heat system The Hague needs a provision in the shape of a geothermal heat system for additional heat supply to approximately 4000 dwellings in the Southwest of The Hague. Some interested persons and residents have questions about the operation of the system, the linkage to the source of geothermal heat, the need for an auxiliary heat boiler, the emission, the operating hours, the noise and the plume formation. This memo contains an explanation of the various components of the geothermal heat plant.

  4. CEA 2009 annual report

    International Nuclear Information System (INIS)

    After an indication of several key figures about the activity of the CEA (Centre d'Etudes Atomiques) and its relationship with the academic as well as the industrial field, in France and worldwide, this 2009 annual report presents its various research programs in the field of defence and of global security: basic research (nuclear weapons and propulsion, struggle against proliferation and terrorism) and applied research (nuclear deterrence, national and international security). Then, it presents the programs in the field of de-carbonated energy: basic research (in material science and in life sciences) and applied research (fission energy, fusion energy, new energy technologies). A last group of research programs deals with information and health technologies and concerns life and material sciences, micro- and nano-technologies, software technologies. Interaction with other research institutions and bodies is also evoked. A brief scientific assessment is proposed. Finally, the different structures building the CEA are presented

  5. CEA - Annual report 2006

    International Nuclear Information System (INIS)

    The CEA, a prominent player in research development and innovation, is active in 3 main areas: energy, health care and information technology and defense and security. This annual report presents the CEA activity for the year 2006 in these three main areas: Science and technology working for nuclear deterrence and global security (the simulation programs, the nuclear warheads, the nuclear propulsion, the decommissioning, the fighting against nuclear proliferation and monitoring international treaties, the global security); health and information technology (micro and nano technologies and systems); energy from nuclear fission and fusion and other technologies that do not emit greenhouse gases (progress for the nuclear industry, sustainable management of radioactive materials and waste, nuclear systems of the future, new energy technologies). (A.L.B.)

  6. CEA and mining industry

    International Nuclear Information System (INIS)

    The French atomic energy commission (CEA) is involved in the mining industry in several ways: - in the front-end of the nuclear industry through its daughter companies and participations in the exploration and exploitation of uranium ores, but also of gold and alloy metals with a 26% participation in Eramet company, the world leader of manganese and nickel. This activity is the main occupation of Cogema daughter company, via the Areva holding; - in the back-end of the nuclear fuel cycle with the delicate problem of the management of radioactive wastes; - in parallel with the nuclear industry through an important activity in semiconductor materials (FCI and SMTElectronics); - and finally through various research works on several mineral compounds. This article focusses on the fuel cycle aspects of the CEA activities and concludes with the research works carried out today on thermonuclear fusion. (J.S.)

  7. Análisis de la variabilidad genética de la colección colombiana de musáceas usando marcadores isoenzimáticos Analysis of the genetic variability of colombian collection of Musaceae using isozyme markers

    OpenAIRE

    Giraldo, Martha C; Gustavo A Ligarreto; Gerardo Cayón; Constanza Melo

    2011-01-01

    La Colección Colombiana de Musáceas (CCM) es la única a nivel mundial que representa un alto valor por ser la que posee introducciones andinas de altura (> 1500 m.s.n.m.). La caracterización de este germoplasma puede generar valor agregado para su utilización en procesos de selección clonal y para el mejoramiento genético de la especie, mediante el uso de materiales diploides con características transmisibles de importancia. Por esta razón, 33 clones de la CCM conservadas in vitro, fueron eva...

  8. CEA sustainable development report 2007; CEA rapport developpement durable 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities in the domain of the sustainable development. The first part is devoted to the environment preservation policy (energy, water, air, chemistry, wastes, transport, buildings). The second part shows the dynamic governance in the domain of the risks management. The last part presents the CEA activities of research for the sustainable development. (A.L.B.)

  9. CEA Annual report 2007; CEA rapport annuel 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities for the year 2007 in these three main areas: science and technology working for nuclear deterrence and global security, the energies without greenhouse effect gases emission against the climatic change, researches in the information sciences and technologies for a better communication and health. The CEA safety, organization, communication and international relations are also presented. (A.L.B.)

  10. Is geographical rarity frequent among the cacti of the Chihuahuan Desert? ¿Es la rareza geográfica frecuente entre las cactáceas del Desierto Chihuahuense?

    Directory of Open Access Journals (Sweden)

    Héctor M. Hernández

    2010-04-01

    Full Text Available With the aim of assessing the extent of geographical rarity of Mexican Cactaceae, we calculated the distribution size (area of occupancy of 142 species from the Chihuahuan Desert. In addition, using 2 variables (number of localities and range size, we preliminarily assessed their conservation status using the current IUCN Red List criteria. The results showed enormous variation in the areas of occupancy, although from the biogeographic and conservation perspective the most exceptional group comprises the extremely narrow endemics (42 species, whose range is restricted to areas smaller than 10 km2. Our results reinforce the reputation of this plant family as exceptionally rare geographically. We suggest that geographical rarity of Cactaceae in the Chihuahuan Desert is a natural phenomenon; however, we propose that the range of several species has been influenced by human activities. Regarding the conservation status of the species, 75 of them are categorized as Least concern. The remaining 67 species (47.2% fall in 1 of the 3 categories of threat (27 Vulnerable, 11 Endangered, and 29 Critically endangered. These figures confirm the critical conservation status of Mexican Cactaceae.Se calculó el tamaño de la distribución (área de ocupación de 142 especies de cactáceas del Desierto Chihuahuense, con el objeto de evaluar su grado de rareza geográfica. Además, mediante el uso de 2 variables (número de localidades y tamaño de distribución, se estimó de manera preliminar su estado de conservación usando los criterios actuales de la Lista Roja de la UICN. Los resultados mostraron gran variación en las áreas de ocupación. Sin embargo, desde una perspectiva biogeográfica y de la conservación, el grupo de especies más excepcional corresponde a las endémicas restringidas (42 spp., cuyas áreas de distribución son menores de 10 km². Los resultados fortalecen la reputación de las cactáceas de ser una familia de plantas excepcionalmente

  11. CEA financial report 2007; CEA rapport financier 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This document provides financial data on the CEA for the year 2007. The management report (budget, resources, expenditures) and the accounting are detailed. The main management events of the year 2007 are presented. (A.L.B.)

  12. Cuéntame un cuento, homeopatía. Desarrollo de una herramienta didáctica sobre la materia médica de un grupo de solanáceas comúnmente utilizadas en Homeopatía

    OpenAIRE

    Cepeda Romero, Julie Catherine

    2013-01-01

    Este trabajo de tesis es requisito parcial para optar al título de Magister en Homeopatía de la Universidad Nacional de Colombia. Bajo la modalidad de producto para docencia y pedagogía, esta tesis suple en parte la necesidad de material didáctico para el aprendizaje de la Homeopatía. Desde la óptica del constructivismo pedagógico, se desarrolla la materia médica de seis solanáceas comúnmente utilizadas como materia prima en la elaboración de seis remedios homeopáticos: Atropa bellad...

  13. CEA - 2014 risk management assessment

    International Nuclear Information System (INIS)

    After introducing presentations of CEA managers in charge of risk management and controls, this document presents and comments the actions undertaken by the CEA and the obtained results in terms of risk management in different fields: protection and control of the environment, installation safety, health, safety and radiation protection, transport of hazardous materials, waste management, protection of sites, installations and heritage, management of emergency situations, management of legal risks, internal audits and controls. Other topics are addressed like the presentation of the risk management department, and the role of the CEA in the relationship between research and industry

  14. CEA sustainable development report 2007

    International Nuclear Information System (INIS)

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities in the domain of the sustainable development. The first part is devoted to the environment preservation policy (energy, water, air, chemistry, wastes, transport, buildings). The second part shows the dynamic governance in the domain of the risks management. The last part presents the CEA activities of research for the sustainable development. (A.L.B.)

  15. Report transparency and nuclear safety 2007 CEA Cadarache; Rapport transparence et securite nucleaire 2007 CEA Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Cadarache for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the report discusses the beginning of the RJH reactor construction, the fourth generation reactors research programs, the implementing of la Rotonde the new radioactive wastes management installation, the renovation of the LECA. (A.L.B.)

  16. Biodiversidad de la microbiota rizosférica de dos especies solanáceas: Solanum lycopersicon, L. y Datura spp. (tomate y toloache)

    OpenAIRE

    López Rivera, Raquel

    2014-01-01

    La microbiota del suelo es un recurso muy importante debido a su alta diversidad, la cual participa en la mayoría de las transformaciones de nutrientes y en otros procesos importantes para las plantas, siendo la rizosfera la zona donde la actividad microbiana suele ser más intensa. En Sinaloa la vegetación natural es escasa debido a que la mayor parte del suelo es utilizado para labores agrícolas, lo que ha llevado a una pérdida de la diversidad de especies nativas. En particular en el munici...

  17. Algunas orquidáceas americanas

    OpenAIRE

    Williams, Louis O.

    2012-01-01

    La presente contribución al conocimiento de las Orquidáceas americanas trata de algunas especies de México, América Central, Sur América y las Antillas. Estas notas son el resultado de determinaciones de varios ejemplares colectados en tales regiones, y que se hallan depositados en el Ames Herbarium, Cambridge, Mass., el United States National Museum, Washington, D. C., el New York Botanical Garden Herbarium, Nueva York, o en el Herbarium of the Missouri Botanical Garden, St.Louis, Missouri....

  18. Decree of January 11, 2016 bearing homologation of the decision nr 2015-DC-0536 by the Nuclear Safety Authority of December 22, 2015 defining threshold values of releases in the environment of liquid and gaseous effluents from base nuclear installations nr 33 (UP2-400), 38 (STE2 et AT1), 47 (ELAN II B), 80 (HAO), 116 (UP3-A), 117 (UP2-800) and 118 (STE3 effluent processing station) exploited by AREVA NC on the La Hague site (Manche district)

    International Nuclear Information System (INIS)

    After having mentioned the various related and reference legal texts, this legal publication specifies the various threshold values which must be applied to liquid and gaseous releases of nuclear installations located in La Hague for a better control and management of pollutions and of the impact of these installations on the environment. Threshold values are thus specified for various compounds and species, and the document also mentions AREVA's publications which indicate the actual release levels and state that these levels are within the accepted limits

  19. Scientific evaluation at the CEA; Evaluation scientifique au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1998. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 5 parts dealing successively with: part 1 - the CEA, a public research organization (civil nuclear research, technology research and transfers, defence activities); the scientific and technical evaluation at the CEA (general framework, evaluation of the IPSN and DAM); part 2 - the scientific and technical councils (directions of fuel cycle, of nuclear reactors, and of advanced technologies); part 3 - the scientific councils (directions of matter and of life sciences); the nuclear protection and safety institute; the direction of military applications; part 4 - the corresponding members of the evaluation; part 5 - the list of scientific and technical councils and members. (J.S.)

  20. CEA Annual progress report 1986

    International Nuclear Information System (INIS)

    This annual report presents the general organization of the CEA, the international relations and politics in nuclear field, the activities (military application, nuclear applied research, ANDRA (National Agency for Radioactive Waste Management), nuclear safety and protection, fundamental research, applied research other than nuclear), the industrial group; among topics about men and means, the budget execution of the public establishment of research. In annex, the nuclear power plants around the world and the principal legislative texts related to CEA or atomic energy published in 1986

  1. CEA 2005 annual report; CEA rapport annuel 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This document is the 2005 activity report of the French atomic energy commission (CEA). The CEA is a main actor of nuclear research, development and innovation and is involved in three main domains: energy, defense/security, and information/health technologies thanks to high quality research works. With a manpower of 15000 researchers and collaborators with internationally acknowledged competences, the CEA is a driving force of industrial innovation and develops partnerships with French and European industries. It also warrants the perenniality of nuclear dissuasion. This report presents these different aspects of the CEA activities: 1 - defense-security: simulation program, opening to the scientific community, nuclear warheads, nuclear propulsion, cleansing of Rhone valley facilities, permanent monitoring of treaties respect, fight against terrorism; 2 - energy: optimization of the industrial park, advances in long lived radioactive wastes management, future nuclear systems, cleansing and dismantling integration, European nuclear energy research, new energy technologies; 3 - information and health technologies: major challenge of micro- and nano-technologies, key role of software technologies and complex systems; 4 - big research facilities opened to the scientific and industrial communities; 5 - scientific status: scientific evaluation process, prices and honors; 6 - programs support: revisited strategic control, confirmed simplification, active employment and training policy, teaching and training, technological valorization, international relations, communication, continuous quality approach, mastery of facilities safety, security, environmental control, a key-year for information systems. A financial report is attached to the document. (J.S.)

  2. INIS, CEA and nuclear terminology; INIS, CEA et terminologie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Surmont, J.; Brulet, C.; Constant, A.; Guille, N.; Le Blanc, A.; Mouffron, O.; Anguise, P.; Jouve, J.J

    2007-07-01

    This poster, prepared for the fifth edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents, first, the INIS information system, its content and coverage, the French participation to this system and the role of the CEA-Saclay as France's official representative for this system. Then it presents the INIS thesaurus with its different levels as a terminological tool for the indexing of documents and for searching documents inside the database. Finally, the very first electronic version of the multilingual thesaurus is introduced. Several national INIS centres, including the CEA-Saclay, have contributed to the translation of lists of new terms and of forbidden terms (synonyms). (J.S.)

  3. CEA - Annual report 2006; CEA - Rapport annuel 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The CEA, a prominent player in research development and innovation, is active in 3 main areas: energy, health care and information technology and defense and security. This annual report presents the CEA activity for the year 2006 in these three main areas: Science and technology working for nuclear deterrence and global security (the simulation programs, the nuclear warheads, the nuclear propulsion, the decommissioning, the fighting against nuclear proliferation and monitoring international treaties, the global security); health and information technology (micro and nano technologies and systems); energy from nuclear fission and fusion and other technologies that do not emit greenhouse gases (progress for the nuclear industry, sustainable management of radioactive materials and waste, nuclear systems of the future, new energy technologies). (A.L.B.)

  4. INIS, CEA and nuclear terminology

    International Nuclear Information System (INIS)

    This poster, prepared for the fifth edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents, first, the INIS information system, its content and coverage, the French participation to this system and the role of the CEA-Saclay as France's official representative for this system. Then it presents the INIS thesaurus with its different levels as a terminological tool for the indexing of documents and for searching documents inside the database. Finally, the very first electronic version of the multilingual thesaurus is introduced. Several national INIS centres, including the CEA-Saclay, have contributed to the translation of lists of new terms and of forbidden terms (synonyms). (J.S.)

  5. CEA: risk management assessment 2011

    International Nuclear Information System (INIS)

    This report proposes a qualitative and quantitative overview of CEA activities in the field of risk management during 2011. These activities concerned the impact on the environment, the safety of installations, the management of professional risks (safety and health at work), the radiological protection of workers, the transports of hazardous materials, waste management, protection of sites, installations and heritage, the management of emergency situations, the management of law risks, controls and audits

  6. The safety of the reprocessing plant of Cogema La Hague

    International Nuclear Information System (INIS)

    The risks associated to the operation of a reprocessing plant come from the important quantities of radioactive matter. To insure the reprocessing safety consists in keeping, in any circumstance, the containment of radioactive matter. That this objective that leads the safety at any step of the factory life. Three risks families are listed: the risks from nuclear origin, associated to the specific physico-chemical behaviours of radioactive matter (dispersion and criticality, thermal risks and risks bound to the hydrogen production); the second family is the group of internal risks resulting from the industrial activity (chemical risks, fire risks, dysfunctions of electric installations or falls of loads); the last family is the group of external risks resulting from the impact of events reaching the site where are established the installations (risks associated to climatic conditions, risks associated to surrounding activities such explosions, fires, impact resulting from the fall of a tourism plane or road transport of hazardous matter). (N.C.)

  7. The organic waste treatment in UP3-La Hague

    International Nuclear Information System (INIS)

    Spent solvent is an organic waste the volume of which must be minimized. It has been decided to implement a distillation facility in order to split this spent solvent into three parts: recovered diluent and concentrated TBP, to be recycled, and a residue which contain the radioactivity and most of the impurities. This distillation is performed at low pressure and temperature, with thin films evaporators, in order to minimize the residence times in heated zones. The paper describes the process and the equipment employed. The R and D work which has been performed to define the process, size up the equipment and demonstrate the process is described, including the laboratory works, the pilot plant tests and the results of tests performed with a full scale prototype which has been built to demonstrate the whole process. The industrial facility, and the results of the first active runs are described briefly

  8. From moon stones to simulation - More than 40 years of experiments on the 7 MV tandem accelerator at Cea/Dam Ile de France; Des pierres de lune a la simulation - Plus de 40 ans d'experiences aupres de l'accelerateur Van de Graaff tandem 7 MV CEA/DAM Ile de France

    Energy Technology Data Exchange (ETDEWEB)

    Bauge, E.; Bersillon, O.; Couillaud, Ch.; Daugas, J.M.; Flament, J.L.; Frehaut, J.; Haouat, G.; Joly, S.; Laborie, J.M.; Ledoux, X.; Marmouget, J.G.; Patin, Y.; Poncy, J.L.; Sigaud, J.; Varignon, C

    2009-07-01

    Following the decommissioning of the 7 MV tandem accelerator of CEA/DAM by the end of 2007, the present report relates the history of the accelerator from its beginning in the sixties and then the nuclear physics studies on fission, (x,xn) reactions, elastic and inelastic scattering, etc and other studies in microelectronics, biology, etc) performed with that installation. (authors)

  9. Report transparency and nuclear safety 2007 CEA Cadarache

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Cadarache for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the report discusses the beginning of the RJH reactor construction, the fourth generation reactors research programs, the implementing of la Rotonde the new radioactive wastes management installation, the renovation of the LECA. (A.L.B.)

  10. Histología comparada de especies de cariofiláceas. Hipótesis sobre la ontogenia del tallo

    OpenAIRE

    Alonso Beato, María Teresa

    1987-01-01

    [ES] En el presente trabajo se realiza el estudio histológico comparado del tallo y las hojas de especies de los géneros Bufonia, Dianthus, Ortegia y Silène. Se han identificado meristemos laterales intra y extravasculares que parecen determinar el crecimiento en grosor del tallo de estas especies. Se describe la fisiología de los mismos proponiendo un modelo de crecimiento. [EN] The present work describes the results of a comparative histological study of the stem and leaves of species of...

  11. CEA - Assessment of risk management 2013

    International Nuclear Information System (INIS)

    After some introducing texts by CEA managers, this report proposes a rather detailed overview and presentation of CEA activities, objectives and obtained results in different fields: protection and control of the environment, installation safety, health, safety and radiation protection, transports of hazardous materials, waste management, protection of sites, installations and heritage, management of emergency situations, management of legal risks, internal controls and audits, activity of the risk management department, CEA activities from research to industry

  12. CEA, a Major Player in Technological Innovation for Defense and Security

    International Nuclear Information System (INIS)

    The Secure Day Conference held in Paris on October 24, 2012 was organized by CEA with the support of the French High Committee for Civil Defense (Haut Comite Francais pour la Defense Civile - HCFDC). The event gathered more than 250 people (institutions, users and industrial companies) and alternated conferences and presentations on about thirty technologies developed in the framework of joint ministerial CBRN-E R and D program entrusted to CEA by public authorities. (authors)

  13. Decontamination and dismantling at the CEA

    International Nuclear Information System (INIS)

    This document presents the dismantling policy at the CEA (French Research Center on the atomic energy), the financing of the decontamination and the dismantling, the regulatory framework, the knowledge and the technology developed at the CEA, the radiation protection, the environment monitoring and the installations. (A.L.B.)

  14. Sertula florae colombiae – xv: nuevas melastomatáceas

    OpenAIRE

    Uribe Uribe, Lorenzo

    2012-01-01

    El notable aumento de las colecciones del Herbario Nacional Colombiano muestran la riqueza de la flora melastomatácea de Colombia. Uno de los géneros más ricos y más bien caracterizados es Blakea. En este artículo describo dos nuevas especies muy interesantes. Dejo consignada mi gratitud para elnotable dibujante, don Silvio Fernández Valencia, a quien se deben las magníficas ilustraciones y muchos datos y mediciones de órganos pequeñísimos, que facilitaron  las descripciones exactas de las pl...

  15. Memoirs of a Cea veteran

    International Nuclear Information System (INIS)

    A brief account is given of the way in which nuclear energy has developed in France and elsewhere over the last fifty years: options developed by the French Atomic Energy Commission (CEA), naval propulsion, development of pressurised water reactors, MOX and thorium fuels. Afterwards, the prospectives for the 21. century will be discussed. Considering that natural resources are depleting while releases of both greenhouse gases and world population are increasing, an active energy policy will have to be implemented with due consideration for social equity and solidarity. It is in this context that the developed countries will have to give preference, beyond savings, to renewable sources of energy, including of course, nuclear energy. Nuclear energy can continue to develop in the long term, provided fast breeder technology is developed at some point. As far as transport is concerned, hydrogen technology, which is clean and renewable, is promising, provided it is generated by nuclear energy. (author)

  16. CEA - 2012 Annual Report, 2012 Financial Statements

    International Nuclear Information System (INIS)

    In its first part, this report proposes an overview of activities within the CEA. They concern the CEA's programs on low on carbon energies and associated fundamental researches, on defence and global security and associated fundamental researches, on information technologies and associated fundamental researches, on health technologies and associated fundamental researches, and on very large research infrastructures and associated fundamental researches. The second part addresses the scientific assessment, activities related to teaching and training, to innovation towards enterprises, and to support to valorization. It also indicates prices awarded to the CEA. The third part addresses CEA management and institutional relationships, human resources, international relationships, activities related to communication and information diffusion, and risk management. The fourth part describes the CEA organization, its governance and its various bodies. The second volume contains the financial statements for 2012

  17. Efecto de la densidad de semillas en la germinación de Isolatocereus dumortieri y Myrtillocactus geometrizans, cactáceas columnares endémicas de México Effect of seed density on germination of Isolatocereus dumortieri and Myrtillocactus geometrizans, endemic columnar cacti species from Mexico

    Directory of Open Access Journals (Sweden)

    Joel Flores

    2009-04-01

    Full Text Available Se evaluó el efecto de la densidad de semillas en la germinación de 2 cactáceas columnares: Isolatocereus dumortieri y Myrtillocactus geometrizans. Se utilizaron 5 tratamientos de densidad de semillas (1, 5, 10, 20 y 50 semillas. Isolatocereus dumortieri mostró menor porcentaje de germinación con el aumento de la densidad, mientras que la germinación de M. geometrizans no fue afectada por la densidad de semillas. Estos resultados sugieren que las plántulas de I. dumortieri podrían competir por recursos.The effect of seed density on the germination of 2 columnar cactus species (Isolatocereus dumortieri and Myrtillocactus geometrizans was evaluated using 5 seed density treatments (1, 5, 10, 20 and 50 seeds. Isolatocereus dumortieri had a lower germination percentage with increasing seed density; germination of M. geometrizans was not affected by seed density. These results suggest that I. dumortieri seedlings might compete for resources with siblings.

  18. Chemistry of complexing molecules and environment. Report of the working group of the Cea ''mission environment''; Chimie des complexants en environnements. Rapport du groupe de travail de la mission environnement

    Energy Technology Data Exchange (ETDEWEB)

    Petit, J.C

    1998-07-01

    The Working group 'Chemistry of Complexing Molecules and Environment' of the Mission Environment (AG/ENV) identified themes for an original positioning of CEA on important issues of environmental research if a sufficiently strong demand appears. The research of CEA on the environment should be complementary to actions undertaken by other partners (official institutions, research organizations and industrial firms). The themes suggested are: the synthesis of new chelating molecules and new materials having specific properties, with the support of theoretical chemistry and modeling, analytical physical chemistry and speciation of species in relation to their eco-toxicity and their biogeochemical mobility in the natural environment. These themes, illustrated by examples of actions in progress at CEA or likely to be launched quickly, draw largely from recognized competences of the teams, generally developed for finalized nuclear applications: experimental, theoretical and instrumental competences. (author)

  19. CEA - 2011 annual report, 2011 financial statement

    International Nuclear Information System (INIS)

    The first report, available both in French and English, presents the different current programs: low carbon energies and associated fundamental researches, global defence and safety and associated researches, information technologies and associated researches, technologies for health and associated fundamental researches, very large research infrastructures and associated fundamental researches. It then addresses the CEA openness: assessment, teaching and training, research valorisation, awards, and the support to various programs: steering activity by the CEA, human resources, international relationships, communication, risk management, information systems. The last part describes the CEA organisation. The second report presents the different financial and accounting data and tables

  20. CEA contribution to advanced robotics

    International Nuclear Information System (INIS)

    Due to development of nuclear energy in France, CEA has a long experience in nuclear robotics. It started from remote handling in hot cells and extended to inspections in nuclear reactors, intervention with vehicles, decommissioning of experimental plants, maintenance and intervention in reactors and reprocessing plants. Existing equipments, which are briefly described, show present status of performances for these applications. Research activities are going-on to develop this potential. Main aspects of recent advances in nuclear robotics are detailed to show that each application has some relevance with fusion remote handling needs. In this panel of activities, fusion would profit more directly from reprocessing and reactor maintenance studies, Computer Aided Teleoperation and advanced manipulators developments. But all the projects in nuclear and servicing robotics may have spin-offs for fusion and mention to Eureka projects will underline the necessity for European cooperation in this field. Finally, honor will be rendered to Jean Vertut who had from the first moment a real passion for fusion. (author). 3 refs, 4 figs, 2 tabs

  1. Planta de lavado para arena silícea

    OpenAIRE

    Rojo García, Cristina

    2008-01-01

    El proyecto fin de carrera trata sobre la instalación de una planta móvil de lavado para arena silícea. Este recurso está presente en el Monte Público nº 90 denominado “RAJICA DE EN MEDIO” en el Término Municipal de Jumilla (Murcia), donde se ubica la cantera “Los Mochuelos” de la que es concesionaria y explotadora la empresa JUMILLANA DE SÍLICE, S.L, con C.I.F. nº B-25.646.720, con domicilio social en C/ Canalejas nº 83, Bajo, de Jumilla (Murcia). Por ello, el presente proyecto tien...

  2. Clinical evaluation of radioassays for calcitonin, CEA-S, AFP and ferritin as tumor markers

    International Nuclear Information System (INIS)

    Clinical usefulness of the radioassays for serum calcitonin, isometric species of carcinoembryonic antigen (CEA-S), alpha-fetoprotein (AFP) and ferritin as the specific tumor markers was evaluated. The calcitonin assay was found to be extremely useful in detecting the cases of familial medullary carcinoma of the thyroid and in monitoring the patients after surgery. The CEA-S assay was proved more specific in titers and positivity for malignancies, especially GI tract carcinomas than CEA assay. The diagnosis of hepatoma could be performed precisely with a combination of 67Ga scintigraphy and assays of CEA and AFP. The serum ferritin levels in malignancies overlapped widely with those of non-malignancies. However, the estimation of ferritin-iron ratio was thought to be a useful means for screening patients with suspicious lesions. (author)

  3. CEA - Assessment of risk management for 2012

    International Nuclear Information System (INIS)

    This report proposes an overview of the main events, actions performed by the CEA, and facts for 2012 regarding protection and monitoring of the environment, installation safety, occupational health and safety, radiological protection of workers, transportation of hazardous materials, waste management, protection of sites, installations and heritage, emergency situation management, legal risk management, internal controls and audits. It also presents the organisation and action of the risk management department within the CEA

  4. The CEA-Industrie Group of Companies

    International Nuclear Information System (INIS)

    The 1988 financial and technological status of the CEA-Industry Group of Companies is summarized. The activities, technological innovations, and areas of development perspectives of the CEA-Industry Group of Companies, chiefly concentrated in fields relating to nuclear energy, are described. The principal business sectors of the group involve nuclear fuel cycle, nuclear plants and maintenance, computer applications and life science. Some activities of the group are extended to management, construction and financial fields

  5. 1999 scientific evaluation at the CEA

    International Nuclear Information System (INIS)

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1999. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 4 parts dealing successively with: 1)the CEA, a public research organization (strategy, research programs, new organization of the CEA activities, civil nuclear research, technology research and transfer, defence activities, transfer of knowledge) 2)the scientific evaluation at the CEA (evaluations of the civil applications of the CEA, IPSN, DAM, INSTN (national institute for nuclear sciences and techniques) 3)synthesis of the 1999 scientific and technical evaluation for each operational directions of the CEA (directions of fuel cycle, of nuclear reactors, of advanced technologies, of materials sciences, of life sciences, of military applications, of the nuclear protection and safety institute and of the national institute for nuclear sciences and techniques) 4)the corresponding members of the evaluation and the list of scientific and technical councils and members

  6. 77 FR 73731 - 30-Day Notice of Proposed Information Collection: Application Under the Hague Convention on the...

    Science.gov (United States)

    2012-12-11

    ... Notice of Proposed Information Collection: Application Under the Hague Convention on the Civil Aspects of... Convention on the Civil Aspects of International Child Abduction. OMB Control Number: 1405-0076. Type of... available for public review. Abstract of proposed collection: The Application Under the Hague Convention...

  7. Report from the production and exchanges commission about the resolution proposal (no 2937) of Mr Noel Mamere which aims at creating an inquiry commission relative to the existence and storage of ultimate nuclear wastes at the Hague plant, in violation of the law from December 30, 1991, and under the liabilities of Cogema

    International Nuclear Information System (INIS)

    This document presents the motives of the French production and exchanges commission for the rejection of the proposal from the French 'green' deputy Noel Mamere about the creation of an inquiry commission which would aim at verifying the illegal storage of irradiated MOX fuels from German nuclear facilities at the Cogema La Hague plant. (J.S.)

  8. Hosting Europe. Local organisation of the Congress of Europe, The Hague

    OpenAIRE

    Beers, M.C.

    2009-01-01

    In May 1948, the Congress of Europe took place in the city of The Hague in The Netherlands. This paper, based on local Dutch sources, describes the local organisation of the congress which was an ambitious enterprise. More than 700 guests had to be provided with accommodation, food and local transport in a period of reconstruction in the aftermath of the Second World War. Moreover, the organisers had to search for sponsors as participants only paid for their transport ticket to The Hague. Sta...

  9. Análisis de la variabilidad genética de la colección colombiana de musáceas usando marcadores isoenzimáticos Analysis of the genetic variability of colombian collection of Musaceae using isozyme markers

    Directory of Open Access Journals (Sweden)

    Martha C Giraldo

    2011-04-01

    Full Text Available La Colección Colombiana de Musáceas (CCM es la única a nivel mundial que representa un alto valor por ser la que posee introducciones andinas de altura (> 1500 m.s.n.m.. La caracterización de este germoplasma puede generar valor agregado para su utilización en procesos de selección clonal y para el mejoramiento genético de la especie, mediante el uso de materiales diploides con características transmisibles de importancia. Por esta razón, 33 clones de la CCM conservadas in vitro, fueron evaluadas bioquímicamente mediante 10 enzimas, de las cuales cuatro fueron polimórficas: glutamato oxaloacetil transaminasa (GOT, ab-esterasa (ab-EST, peroxidasa (PRX y diaforasa (DIAP. La enzima GOT fue la más discriminante entre grupos genómicos particulares. PRX, DIAP y ab-EST permitieron evaluar la variabilidad al interior de cada grupo. El estudio facilita el entendimiento de la estructura genética de los genotipos de plátano y banano cultivados en Colombia.The Colombian Collection of Musaceae (CCM represents a great value to the world agriculture for being the only one with high Andean germplasm. The characterization of this germplasm can generate added value to use in processes of clone selection and breeding of the species by using diploid materials with desirable traits to be transferred and thus help alleviate food problems in poor countries. For this reason the CCM 33 clones conserved in vitro, were assessed biochemically using 10 enzymes of which four were polimorfics: oxaloacetil transaminasa glutamate (GOT, ab-esterase (ab-EST, peroxidase (PRX and diaphorase (DIAP. The GOT enzyme was the most discriminating among individual genomic groups. PRX, ab-EST and DIAP allowed us to evaluate the variability within each group. The study provided a better understanding of the genetic structure of the genotypes of plantain and banana grown in Colombia.

  10. Analysis and discussion on reports of additional safety assessment of nuclear installations with respect to the Fukushima accident; Analyse et commentaire des rapports d'evaluation complementaire de la surete des installations nucleaires au regard de l'accident de Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Sene, Monique; Sene, Raymond

    2011-11-15

    This document proposes an analysis of the reports made by the different operators of nuclear installations within the frame of a safety audit of the French nuclear installations with respect to the Fukushima accident. Operators (mainly AREVA, the CEA and EDF) were asked to perform additional safety assessments. In a first part, the conclusions of EDF reports are analysed regarding the seismic risk, the flooding risk, the situation of some specific sites (Fessenheim, Tricastin), other phenomena (rains, winds), loss of electricity supplies and of cooling systems, severe accidents, hydrogen issue, chemical hazards, subcontractors, crisis management. Conclusions of AREVA reports are analysed for the different sites (Tricastin, La Hague, MELOX factory, Romans factory). Conclusions of CEA reports are analysed for the different concerned installations (ATPu, Masurca, Osiris, Phenix, Jules Horowitz reactor). A second part proposes a global analysis of EDF's additional safety assessment reports regarding earthquake, flooding, other extreme natural phenomena, loss of electricity supplies and cooling system, subcontracting conditions, crisis management, and radiation protection organisation. AREVA's and CEA's reports are then analysed in terms of report structure and content, and for the different concerned sites

  11. Decontamination and dismantling at the CEA; L'assainissement et le demantelement au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This document presents the dismantling policy at the CEA (French Research Center on the atomic energy), the financing of the decontamination and the dismantling, the regulatory framework, the knowledge and the technology developed at the CEA, the radiation protection, the environment monitoring and the installations. (A.L.B.)

  12. La medición y vigilancias de la enfermedad de la mancha foliar producida por la sigatoka negra (Mycospharella fijiensis var diformis Morelet) en la producción de musáceas: un enfoque para lograr la sostenibilidad del desarrollo

    OpenAIRE

    Edgardo Vargas Jarquín

    2013-01-01

    En el presente trabajo se discute la necesidad de utilizar tecnología, como el procesamiento digital de imágenes para mejorar los procesos de medición y vigilancia de la enfermedad de la mancha de la hoja causada por SIGATOKA NEGRA (Mycospharella fijiensis var diformis Morelet), pero partiendo de un análisis epistemológico que fundamenta al desarrollo sostenible, que es el marco dentro del cual se encuentra sentido a la aplicación de esta tecnología. Así se define que es la gobernabilidad ben...

  13. Presentation of CEA Marcoule laboratory department

    International Nuclear Information System (INIS)

    The CEA Marcoule Laboratory Department initially dedicated to production support, has recently been renovated to perform a wide range of analyses to support dismantling of plant operation and process development units. It provides services to the operators of the CEA Marcoule Research Center in the fields of analytical chemistry, metallographic examinations, radioactivity measurements, in situ or online nuclear measurements, decontamination processes and industrial chemistry studies. The facilities are designed to analyze all types of nuclear industrial and research samples both under inactive conditions and in glove box and hot cell environments. The Marcoule Laboratory today combines the skills of CEA researchers and AREVA NC analysts in support of production and R and D, process development and dismantling activities at Marcoule or other nuclear sites. (authors)

  14. Education for Public Policy and Management: Views from the Institute of Social Studies, The Hague

    NARCIS (Netherlands)

    D.R. Gasper (Des); J.W. Björkman (James Warner); V. Moharir (Vasant); M.E. Wuyts (Marc)

    2000-01-01

    markdownabstractIntroduction When the Institute of Social Studies, ISS, was founded in 1952 in The Hague as a postgraduate centre for teaching and research on social and economic development, it established the first Masters programme in public administration and the first professorial chair in th

  15. Reagents for radioimmunological determination of carcinoembryonic antigen (CEA)

    International Nuclear Information System (INIS)

    The work was undertaken to prepare the reagents for carcinoembryonic antigen (CEA) radioimmunoassay with double antibody method. The CEA standard of high immunoreactivity was prepared and purified. The purified CEA was used for immunozation of goats. The goat anti - CEA sera were received. IgG fraction from normal goat serum was purified and used for the production of horse anti-goat IgG serum which was then used in the radioimmunoassay of CEA. The labelling of CEA with iodine-125 has been carried out be means of the enzymatic method.(Z.R.)

  16. Aportación al conocimiento de las algas epicontinentales del S.E. de España. VI. Dinofíceas (Dinophyceae Fritsch. 1927) y Euglenofíceas (Euglenophyceae Schoenichem, 1925).

    OpenAIRE

    Aboal Sanjurjo, Marina

    1990-01-01

    En prospecciones algológicas realizadas durante los años 1982-85 por todo el sudeste español y en especial en la cuenca del Segura se han identificado 7 táxones de Dinofíceas y 15 de Euglenofíceas. 18 de ellas son novedad para la flora algológica del sudeste español y 3 para la flora española. Se reúnen en tablas los valores de los principales factores físicoquímicos del agua para cada especie

  17. Press tour Siloe CEA/GRENOBLE

    International Nuclear Information System (INIS)

    The experimental reactor, Siloe, has been stopped the 23 december 1997. This paper of the Cea Grenoble, presents the historical aspects of this reactor and its missions. It gives then a global description of the stopping and dismantling procedure, with the planning, the financing and the human impacts of the operation. The wastes management is also takes into account. (A.L.B.)

  18. Estructura factorial y fiabilidad de un cuestionario de estrategias de aprendizaje en universitarios: CEA-U

    OpenAIRE

    Martín Cabrera, Eduardo; García García, Luis Alberto; Torbay Betancor, Ángela; Rodríguez Blanco, Teresa

    2007-01-01

    Se analiza la estructura factorial y la consistencia interna del Cuestionario de Estrategias de Aprendizaje en Universitarios (CEA-U) a partir de las respuestas de 1105 estudiantes de segundo ciclo de carrera universitaria,. El cuestionario está formado por tres escalas: estrategias motivacionales, cognitivas y metacognitivas, en las que el análisis factorial exploratorio arroja once factores empíricos. En un análisis factorial de segundo orden, los once factores se agrupan en tres macrofacto...

  19. 1999 scientific evaluation at the CEA; L'evaluation scientifique 1999 au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1999. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 4 parts dealing successively with: 1)the CEA, a public research organization (strategy, research programs, new organization of the CEA activities, civil nuclear research, technology research and transfer, defence activities, transfer of knowledge) 2)the scientific evaluation at the CEA (evaluations of the civil applications of the CEA, IPSN, DAM, INSTN (national institute for nuclear sciences and techniques) 3)synthesis of the 1999 scientific and technical evaluation for each operational directions of the CEA (directions of fuel cycle, of nuclear reactors, of advanced technologies, of materials sciences, of life sciences, of military applications, of the nuclear protection and safety institute and of the national institute for nuclear sciences and techniques) 4)the corresponding members of the evaluation and the list of scientific and technical councils and members.

  20. CEA: place and role in national science and industry

    International Nuclear Information System (INIS)

    The data on the main trends in CEA activity are given. The role, which CEA plays in French scientific and engineering spheres, is estimated. Examples of CEA international links are discussed, and its contribution into the World scientific and technical progress is shown

  1. Effects of low temperature acclimation on photosynthesis in three Chilean Proteaceae Efectos de la aclimatación a baja temperatura sobre la fotosíntesis de tres proteáceas chilenas

    Directory of Open Access Journals (Sweden)

    MAURICIO CASTRO-ARÉVALO

    2008-09-01

    each species presents functional differences according to the characteristics of light availability and temperature changes of their habitats.Embothrium coccineum, Gevuina avellana y Lomaría ferruginea crecen en habitat contrastantes en temperatura e intensidad lumínica. Embothrium coccineum es una especie pionera que se establece en sitios abiertos, completamente expuestos a luminosidad y temperatura variables. Gevuina avellana se encuentra usualmente en sitios más protegidos. Lomaría ferruginea regenera bajo el dosel en sitios con bajas oscilaciones térmicas y alta humedad. Con el objetivo de establecer una asociación de los habitats que ocupan estas especies y los atributos funcionales de cada una de ellas, se estudió las respuestas fotosintéticas a la temperatura e intensidad lumínica. Un grupo de plantas de cada especie (seis individuos por especie se aclimataron a 4 °C (plantas aclimatadas al frío. Otro grupo con el mismo número de individuos fue mantenido a 20 °C (plantas no aclimatadas al frío. Plantas no aclimatadas de E. coccineum, presentaron una tasa fotosintética máxima, medida como evolución de 0(2, a 30 °C (16,5 ^mol 0(2 m"²s_1 con un óptimo entre 20 y 35 °C, mientras que en G. avellana y L. ferruginea la mayor tasa fotosintética (~13 ^mol 0(2 m"² s"¹ se obtuvo a 25 °C. La aclimatación al frío redujo significativamente las tasas fotosintéticas de las especies. El Q10 para la evolución de 0(2 fue similar en las tres especies en el estado no aclimatado al frío. La aclimatación al frío disminuyó Q10 en E. coccineum y G. avellana, pero permaneció invariable en L. ferruginea. Los parámetros de fluorescencia del PSII mostraron que E. coccineum presentó un mayor rendimiento cuántico efectivo del PSII (PSII a ambas temperaturas crecimiento. El apagamiento fotoquímico (qP fue más afectado por la densidad de flujo fotónico fotosintético (PPFD en L. ferruginea que en las otras especies. Lomatia ferruginea presentó el mayor

  2. Value-added norms, local litigation, and global enforcement : why the Brussels-philosophy failed in The Hague

    OpenAIRE

    Calliess, Gralf-Peter

    2005-01-01

    In the early Nineties the Hague Conference on International Private Law on initiative of the United States started negotiations on a Convention on the Recognition and Enforcement of Foreign Judgments in Civil and Commercial Matters (the "Hague Convention").[1] In October 1999 the Special Commission on duty presented a preliminary text,[2] which was drafted quite closely to the European Convention on Jurisdiction and Enforcement of Judgments in Civil and Commercial Matters (the "Brussels Conve...

  3. Operation of Geothermal Heat System in The Hague, Netherlands; Bedrijfsvoering Aardwarmte Den Haag

    Energy Technology Data Exchange (ETDEWEB)

    Schoof, F.

    2010-01-15

    Geothermal Heat system The Hague needs a provision in the shape of a geothermal heat system for additional heat supply to approximately 4000 dwellings in the Southwest of The Hague. Some interested persons and residents have questions about the operation of the system, the linkage to the source of geothermal heat, the need for an auxiliary heat boiler, the emission, the operating hours, the noise and the plume formation. This memo contains an explanation of the various components of the geothermal heat plant. [Dutch] Aardwarmte Den Haag (ADH) heeft een voorziening in de vorm van een aardwarmtecentrale nodig voor aanvullende warmtelevering aan circa 4000 woningen in Den Haag Zuid-West. Bij sommige geinteresseerden en omwonenden bestaan vragen over de werking van het systeem, de koppeling met de aardwarmtebron, de noodzaak van een hulpwarmteketel, de uitstoot, de bedrijfsuren, het geluid en de 'pluimvorming'. Deze notitie bevat een toelichting op de verschillende onderdelen van de aardwarmtecentrale.

  4. Creation, synthesis and characterisation of nitrogenous poly-heterocyclic new molecules for specific complexation of metallic cations; Conception, synthese et caracterisation de molecules polyheterocycliques azotees pour la complexation specifique de cations metalliques

    Energy Technology Data Exchange (ETDEWEB)

    Dupont, C.

    2010-12-10

    In France, the nuclear waste issued from the industrial reprocessing of spent nuclear fuels (by the PUREX process) are currently vitrified at the La Hague plant, waiting for a final disposal in a deep geological repository. The law voted in June 2006 on the management of highly active nuclear waste plans to look for solutions enabling the separation and transmutation of long-lived radionuclides so as to reduce the quantity and noxiousness of the final nuclear waste. To address this issue, the CEA investigates and elaborates advanced separation processes based on specially designed complexing or extracting molecules to selectively extract minor actinides from PUREX raffinates containing fission products like lanthanides, which are neutron scavengers. BTP or bis-triazinyl-pyridines have been extensively studied at the CEA (and in Europe) for actinides(III)/lanthanides(III) separation. They complex actinides(III) selectively. However, they are sensitive to degradation by hydrolysis and radiolysis. Besides, their separation mechanisms are not well understood, especially the influence of their substituting groups on their complexing and extracting properties. The first part of work reports the syntheses of various BTP and BTBP molecules, differently substituted, as well as a new family of poly-aromatic nitrogen-contained ligands: BPBT, presenting a pyridine/triazine sequence that has never been reported in the literature. The second part is devoted to the physico-chemistry studies of the synthesized molecules, such as the determination of their protonation and complexation constants to describe the influence of different substituting groups. Finally, the last part outlines solvent extraction studies by using these ligands either like extractants or like complexants. (author) [French] Resume: La loi du 6 juin 2006 sur la gestion des dechets radioactifs de haute activite et a vie longue prevoit la recherche de solutions permettant la separation et la transmutation des

  5. Observation on CEA and IL-6 contents in gastric juice

    International Nuclear Information System (INIS)

    Objective: To study the changes of CEA and IL-6 contents in blood and gastric juice in patients with gastric cancer and gastritis. Methods: CEA and IL-6 contents in blood and gastric juice were measured with RIA in 60 patients and 30 controls. Results: Gastric juice CEA and IL-6 contents in patients with gastric carcinoma were significantly higher than those in the controls (p < 0.001), however, CEA and IL-6 contents in patients with gastritis and controls were not much different. Conclusion: Gastric juice CEA and IL-6 assay is of diagnostic significance in patients with gastric malignant tumor

  6. CEA/Valduc Plutonium Recycling Facility Project

    International Nuclear Information System (INIS)

    Pu recycling activities are operated in the 118 facility on Valduc CEA/DAM center. This facility, built in 1963, does not meet modern safety requirements especially for fire and earthquake hazards. The last safety review commission in 2000 gave the authorization to continue recycling operations in the 118 facility until the end of 2010 with the obligation of the achievement, of a safety upgrade program in 2005. At the same time, CEA/DAM has decided to launch the project for the building of a new facility for Pu recycling and legacy residues stabilization. In addition to specific requirements for Pu metal preparation, the processes retained for this facility have to optimize safety, wastes, costs and dosimetry. Moreover, all wastes have to be suitable for discard or of for a safe long term storage in nuclear vault. First conceptual design elements and important basic safety requirements will be presented in this communication. (authors)

  7. The CEA contribution to quality control

    International Nuclear Information System (INIS)

    The Commissariat a l'Energie Atomique has developed original methods and techniques for testing delicate components of the primary circuit of pressure water reactors. These techniques make use of a very wide range of non destructive testing methods: Eddy currents, particularly multiple frequencies, for testing steam generator tubes, gudgeon and other pins focused ultrasonics for testing all the welds of the reactor vessel and its cover plate, mixed welds of steam vessels and generators, low welds of the pressurizer and gudgeon pins from the inside. On site use is effected with specific machines intended either for inspecting the tube bundles of steam generators under the responsibility of INTERCONTROLE Co., or for the complete examination of the reactor vessel by mixed CEA/INTERCONTROLE crews under the responsibility of the CEA. All these operations are subjected to a programme of quality assurance that provides the guaranty of execution complying with the procedures in force

  8. When environment specialists meet the CEA

    International Nuclear Information System (INIS)

    The Afite, the French association of environment engineers and technicians, has organized in May 26 and 27, 1997 a visit of the Cadarache and Marcoule CEA's laboratories devoted to environmental research. The CEA (the French Atomic Energy Commission) and its associated companies represent about ten research centres in which original techniques are developed in order to solve some environmental problems related to nuclear and non-nuclear activities. This paper presents the main environmental research activities carried out at the Cadarache and Marcoule centres: climate evolution and global environment, seismic risks, industrial risks, plants/environment interactions (removal of pollutants, hydrocarbons and heavy metals from the soil), radioactive wastes characterization and processing, cycles of pollutants, nuclear fuels enrichment (SILVA process), remote handling techniques, spent fuels reprocessing, confinement of nuclear wastes and dismantling of nuclear installations. (J.S.)

  9. Ecotoxicological monitoring at CEA - Centro Experimental Aramar

    International Nuclear Information System (INIS)

    The environmental preservation has been one of the major targets of the Centro Experimental Aramar (CEA), since its foundation. The research center is located near Ipero, SP, and is maintained by Centro Tecnologico da Marinha em Sao Paulo - CTMSP. An Environmental Monitoring Program is developed with many types of matrices being periodically collected and analysed, including all the gaseous and liquids emissions liberated by the facilities. Besides radiometric and chemical analysis we have been testing bioassays for the effluents to accomplish the new recommendations from governmental agencies. The microcrustacean Daphnia similis has been tested in toxicity assays on liquid effluents and the garden plant Tradescantia pallida has been used to assess the genotoxicity effects from gaseous emissions. The results show that liquid and gaseous emissions from CEA are bellow the regulatory levels. (author)

  10. CEA: assessment of risk management 2011

    International Nuclear Information System (INIS)

    This report proposes an overview of CEA activities in the field of risk management in different areas: impact on the environment, installation safety, management of occupational risks (occupational health and safety), radiological protection of workers, transportation of hazardous materials, waste management, protection of sites, installations and heritage, management of emergency situations, management of law risks, controls and audits. It finally presents the risk management department

  11. Structural Integrity Analysis of CEA Change Platform

    International Nuclear Information System (INIS)

    The Control Element Assembly Change Platform (CEA CP) is similar to a gantry crane. The CEA CP for Shin-Kori units 3 and 4 (SKN 3 and 4) consists of a bridge, which spans the reactor cavity pool and a gantry superstructure mounted on the bridge. The structure is approximately 8.8 m wide, 4.9 m long and 10.6 m high. The gantry superstructure supports one ton capacity hoist trolley and the bridge supports the In Core Instrumentation (ICI) retrieval cart which moves along the bridge. This paper presents the dynamic and structural analysis of CEA CP which is greater than that of the previous nuclear power plants to verify the structural integrity under the application of the earthquake spectrum. The analysis have been performed using the three orthogonal SSE response spectrum for SKN 3 and 4 which shows much higher acceleration value than OPR- 1000 Plants. In addition, the analyses are performed by 3-dimensional finite element analysis using ANSYS software

  12. Report transparency and nuclear safety 2007 CEA Grenoble; Rapport transparence et securite nucleaire 2007 CEA Grenoble

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Grenoble for the year 2007. Since 2002 the Passage project aims to realize the decontamination and the dismantling of old nuclear installations of the CEA Grenoble. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the year 2007 saw two main steps of the Passage project: the decommissioning of the Siloette reactor, a public consultation about the Lama laboratory dismantling. (A.L.B.)

  13. Estudio del comportamiento de la temperatura del aire (1996-1998, en lote productor de musáceas, estación local Chama, sur del lago de Maracaibo, Estado Zulia, Venezuela

    Directory of Open Access Journals (Sweden)

    Vidal Sáez Sáez

    2001-01-01

    Full Text Available Diversos estudios han demostrado la complejidad de las relaciones que existen entre el clima, los cultivos, las plagas y las enfermedades. La caracterización de éstos vínculos exigen de procedimientos acordes para identificar la diversidad de situaciones que se pueden presentar dentro de ésta realidad, y una de las debilidades que puede surgir es el empleo de registros de estaciones meteorológicas convencionales, aquellas que se encuentran por lo general fuera de los cultivos y se encuentran al aire libre. Esta investigación trata de demostrar las diferencias que se presentan en los registros de la temperatura del aire y su relación con la presencia de un hongo en un lote de producción de plátanos, en la estación Local Chama, Sur del Lago de Maracaibo, Estado Zulia en Venezuela. Con registros de la temperatura del aire de dos estaciones, una dentro del cultivo (1235 y otra fuera (1234, se estimaron las diferencias entre los dos puntos. Se correlacionaron los registros de ambas estaciones con los valores observados de severidad de ataque del hongo sigatoka negra (Mycosphaerella fijiensis Morelet. Se encontró que las correlaciones estadísticamente significativas corresponden a la estación dentro del cultivo, en el lapso de la TARDE (r2 =0,408; r tab = 0,269; 58 g.l.; a = 5% en el intervalo de 15 días de promedio de la temperatura del aire. Se concluye que los resultados orientan sobre la diferencia evidente que se encuentran entre el uso de registros de las estaciones dentro del cultivo con respecto a las observadas fuera de ella al describir la severidad de ataque del hongo en las plantaciones.

  14. Factores abióticos que influencian la germinación de seis especies herbáceas de la zona árida de Chile Abiotic factors effects influencing the germination of six herbaceous species of Chilean arid zone

    Directory of Open Access Journals (Sweden)

    Paola A Jara

    2006-09-01

    Full Text Available La zona árida del norte de Chile presenta un clima seco que impide la emergencia masiva de especies vegetales, excepto cuando se producen escasas e irregulares precipitaciones que modifican las características de aridez y estimulan la germinación de semillas. Los principales factores externos que modifican estructuras y condiciones internas de las semillas son el tiempo de hidratación, iluminación, temperatura y escarificación. En este trabajo se abordaron dos interrogantes: (a ¿la germinación de semillas de seis especies de zonas áridas es regulada por diferentes factores externos o presentan respuestas comunes a una combinación de estímulos? y (b ¿existe correspondencia entre las condiciones germinativas establecidas en laboratorio y las determinadas in situ? Para resolver estas interrogantes se sometieron seis especies herbáceas endémicas y nativas del norte de Chile (Cistanthe salsoloides, Leucocoryne purpurea, Pasithea coerulea, Placea amoena, Schizanthus litoralis y Trichopetalum plumosum a dos experimentos germinativos con combinaciones factoriales de tiempo de hidratación, temperatura e iluminación. Solo S. litoralis fue sometido a un experimento adicional de escarificación y deshidratación. Los resultados determinaron que todas las especies en estudio presentaron respuestas germinativas comunes frente a determinados factores externos, con una máxima germinación al sobrepasar un umbral de 96 h de hidratación y permanecer a niveles de temperatura de 10 a 25 ºC. La respuesta frente a iluminación fue especie dependiente. Schizanthus litoralis solo responde a estímulos externos previo a ser escarificada su semilla. Además, se determinó que existe concordancia entre los factores germinativos determinados en laboratorio y las condiciones naturales de germinación. Por lo tanto, las semillas de las especies en estudio presentan umbrales germinativos semejantes, y las técnicas de germinación en laboratorio deben ser

  15. Carcinoembryonic antigen (CEA) level, CEA ratio, and treatment outcome of rectal cancer patients receiving pre-operative chemoradiation and surgery

    International Nuclear Information System (INIS)

    To investigate serum carcinoembryonic antigen (CEA) as a prognostic factor for rectal cancer patients receiving pre-operative chemoradiotherapy (CRT). Between 2000 and 2009, 138 patients with advanced rectal cancer receiving CRT before surgery at our hospital were retrospectively classified into 3 groups: pre-CRT CEA <6 ng/ml (group L; n = 87); pre-CRT CEA ≥ 6 ng/ml and post-CRT CEA <6 ng/ml (group H-L; n = 32); and both pre- and post-CRT CEA ≥ 6 ng/ml (group H-H; n = 19). CEA ratio (defined as post-CRT CEA divided by pre-CRT CEA), post-CRT CEA level and other factors were reviewed for prediction of pathologic complete response (pCR). Five-year disease-free survival (DFS) was better in groups L (69.0%) and H-L (74.5%) than in group H-H (44.9%) (p = 0.024). Pathologic complete response was observed in 19.5%, 21.9% and 5.3% of groups L, H-L and H-H respectively (p = 0.281). Multivariate analysis showed that ypN stage and pCR were independent prognostic factors for DFS and that post-CRT CEA level was independently predictive of pCR. As a whole, post-CRT CEA <2.61 ng/ml predicted pCR (sensitivity 76.0%; specificity 58.4%). For those with pre-CRT CEA ≥6 ng/ml, post-CRT CEA and CEA ratio both predicted pCR (sensitivity 87.5%, specificity 76.7%). In patients with pre-CRT serum CEA ≥6 ng/ml, those with “normalized” CEA levels after CRT may have similar DFS to those with “normal” (<6 ng/ml) pre-CRT values. Post-CRT CEA level is a predictor for pCR, especially in those with pre-CRT CEA ≥6 ng/ml

  16. Status of Cea spallation modules for ads

    International Nuclear Information System (INIS)

    In the framework of CEA studies on ADS dedicated to waste transmutation, a liquid metal reference concept and an alternative solid target have been evaluated to produce neutrons inside the spallation module. This work examines the design (neutronic, thermohydraulic and mechanical aspects) and the performances of both options. It is shown that a liquid Pb-Bi target offers more possibilities regarding to high protons current densities (possible industrial extrapolation) but that a solid target made with tungsten particles offers also interesting ability to create a neutrons flux appropriated (strong spectrum and flat axial distribution) to an sub-critical core dedicated to incineration. (author)

  17. VALIDACIÓN DE UNA METODOLOGÍA MULTIRRESIDUO PARA LA DETERMINACIÓN DE RESIDUOS DE PLAGUICIDAS EN REPOLLO (Jirassica Olerácea var Capitata. POR CROMATOGRAFÍA DE GASES

    Directory of Open Access Journals (Sweden)

    Milton Leonardo Moreno

    2010-11-01

    Full Text Available En este estudio se diseñó y validó una metodología multirresiduo para el análisis de los plaguicidas organoclorados, organofosforados y organonitrogenados más usados en repollo en el departamento de Cundinamarca, Colombia. El proceso de extracción incluye la homogeneización de una pequeña cantidad de muestra con acetato de etilo en presencia de Na2S04 y NaHCO3 filtración y concentración. Los pasos de limpieza implican GPC y cromatografía en minicolumna sobre silica gel. La determinación analítica se realiza por cromatografía de gases con inyección splítless pulsada, columna capilar HP-5 y un sistema de detección en paralelo con detectores de micro captura electrónica (p-ECD y nitrógeno-fósforo (NPD. La metodología es específica, selectiva, precisa y robusta. Los porcentajes de recuperación de la mayoría de los compuestos estuvieron entre 70-120%, al fortificar con niveles de concentración entre 0,05-10,73 mg/kg. Los límites de detección fueron siempre inferiores a 0,10 mg/kg para la mayoría de los compuestos. Con respecto a la distribución del analito en la muestra, se demostró su homogeneidad. La evaluación de la residualidad de plaguicidas se realizó en el municipio de Madrid, el mayor productor de repollo en Cundinamarca, Colombia, donde no se encontraron residuos de los analitos evaluados en este estudio.

  18. Simplifying CEA through Excel, VBA, and Subeq

    Science.gov (United States)

    Foster, Ryan

    2004-01-01

    Many people use compound equilibrium programs for very different reasons, varying from refrigerators to light bulbs to rockets. A commonly used equilibrium program is CEA. CEA can take various inputs such as pressure, temperature, and volume along with numerous reactants and run them through equilibrium equations to obtain valuable output information, including products formed and their relative amounts. A little over a year ago, Bonnie McBride created the program subeq with the goal to simplify the calling of CEA. Subeq was also designed to be called by other programs, including Excel, through the use of Visual Basic for Applications (VBA). The largest advantage of using Excel is that it allows the user to input the information in a colorful and user-friendly environment while allowing VBA to run subeq, which is in the form of a FORTRAN DLL (Dynamic Link Library). Calling subeq in this form makes it much faster than if it were converted to VBA. Since subeq requires such large lists of reactant and product names, all of which can't be passed in as an array, subeq had to be changed to accept very long strings of reactants and products. To pass this string and adjust the transfer of input and output parameters, the subeq DLL had to be changed. One program that does this is Compaq Visual FORTRAN, which allows DLLs to be edited, debugged, and compiled. Compaq Visual FORTRAN uses FORTRAN 90/95, which has additional features to that of FORTRAN 77. My goals this summer include finishing up the excel spreadsheet of subeq, which I started last summer, and putting it on the Internet so that others can use it without having to download my spreadsheet. To finish up the spreadsheet I will need to work on debugging current options and problems. I will also work on making it as robust as possible, so that all errors that may arise will be clearly communicated to the user. New features will be added old ones will be changed as I receive comments from people using the spreadsheet

  19. ASTER Observations of 2000-2007 Thermal Features at Pavlof Volcano and Mt. Hague (Emmons Lake Volcanic Center), Alaska

    Science.gov (United States)

    Wessels, R. L.; Schneider, D.; Ramsey, M.; Mangan, M. T.

    2007-12-01

    Emmons Lake Volcanic Center (ELVC) is a 15 km by 30 km area of nested calderas, stratovolcanoes, lava domes, hyaloclastite rings, and cinder cones aligned along the arc axis. Pavlof Volcano is the most active volcano along the ELVC, with more than 40 historic eruptions since 1790. The most recent eruption of Pavlof Volcano began in August 2007 after almost 11 years of quiescence. Mount Hague is a prominent intracaldera vent with no known historical eruptions that lies approximately 7 kilometers to the southwest of Pavlof. The southern crater of Mount Hague commonly fluctuates between a crater-filling lake to a dry crater floor with vigorously steaming fumaroles. Mount Hague has another fumarole field on the southeast flank at nearly the same elevation as the crater floor. To better document the behavior of persistent thermal features at these remote volcanoes, we have compiled temperature and dimension data using a seven-year long time series of satellite data. Over 25 daytime and 40 nighttime clear thermal infrared (TIR) images (90 m resolution) from the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) have recorded variations in the thermal activity at both volcanic vents since July 2000. All cloud-free ASTER TIR observations document persistent low- temperature features at both Pavlof Volcano and Mount Hague during this period. The size and temperature of each thermal feature varies throughout the study period. The data show that the 2518 m summit of Pavlof Volcano is occasionally snow-free in early summer whereas neighboring peaks at lower elevations are still snow-clad. FLIR data acquired near the summit of Pavlof in 2004 show that the majority of warm ground was at 20°C to 40°C. These warm areas commonly persist snow-free into the winter. Temperature variations observed at Mt Hague crater usually correlate to the size of the ephemeral crater lake. As the lake grows, the pixel-integrated ASTER TIR temperature increases. Measurements

  20. VALIDACIÓN DE UNA METODOLOGÍA MULTIRRESIDUO PARA LA DETERMINACIÓN DE RESIDUOS DE PLAGUICIDAS EN REPOLLO (Jirassica Olerácea var Capitata.) POR CROMATOGRAFÍA DE GASES

    OpenAIRE

    Milton Leonardo Moreno; Jairo Arturo Guerrero Dallos

    2010-01-01

    En este estudio se diseñó y validó una metodología multirresiduo para el análisis de los plaguicidas organoclorados, organofosforados y organonitrogenados más usados en repollo en el departamento de Cundinamarca, Colombia. El proceso de extracción incluye la homogeneización de una pequeña cantidad de muestra con acetato de etilo en presencia de Na2S04 y NaHCO3 filtración y concentración. Los pasos de limpieza implican GPC y cromatografía en minicolumna sobre silica gel. La determinación a...

  1. Le pilotage de la performance par les valeurs à travers une approche systémique : le cas du centre de recherche intégré MIRCen (CEA)

    OpenAIRE

    Schindler, Aude; Dudezert, Aurélie

    2007-01-01

    A l'heure des pôles de compétitivité et de la concurrence internationale, le pilotage de la performance est l'une des principales priorités des entreprises. Cette performance n'est plus uniquement l'image de critères économiques, mais intègre également d'autres dimensions : sociale, environnementale, scientifique, humaine, éthique... Ces différentes dimensions peuvent être appelées les valeurs de l'entreprise. Les critères de performance sont quantitatifs ou qualitatifs et évoluent au cours d...

  2. Superconducting quadrupoles for LHC : CERN/CEA-CEN Saclay Collaboration

    CERN Multimedia

    CEA Saclay and CERN Collaboration

    1994-01-01

    Agreement has been signed between CERN and CEA Saclay, concerning the construction of two prototypes of the LHC latest quadrupoles. CEA Saclay was interested with the study, the design, the construction and the testing of this magnet. The fabrication took place at the CEN Laboratory at Saclay in Paris.

  3. Low carbon energies: action by the CEA

    International Nuclear Information System (INIS)

    In future decades we can expect the situation regarding energy and climate change to become more and more difficult. On one hand, population growth and essential development in emerging economies will increase the demand for energy; on the other, the depletion of fossil fuel reserves, procurement difficulties due to geopolitical tension, and global warming are all making the search for viable and competitive alternatives to hydrocarbons all the more urgent. In the 2007 edition of its World Energy Outlook report, the International Energy Agency (IEA) made the position clear. CEA is one of the major European research institutes working in the field of energy, he is part of European Energy Research Alliance (EERA). (authors)

  4. The Grenoble CEA Center: dismantled and rehabilitated

    International Nuclear Information System (INIS)

    The denuclearization program of the CEA center in Grenoble was launched in 2001. It involves 6 nuclear facilities (3 research reactors: Melusine, Siloette, and Siloe, and 1 laboratory (LAMA) and 2 units for processing wastes). The dismantling works were finished at the end of 2012 and the 2013 program concerns: the demolition of the buildings homing Melusine and Siloe reactors, the final rehabilitation of the Siloe raft, and the final rehabilitation of the laboratory and of the waste processing units. The budget is 117*106 euros for Siloe, 28*106 euros for Melusine, 6*106 euros for Siloette, 70*106 euros for the LAMA, and 90*106 euros for the 2 waste processing units. (A.C.)

  5. The complementary safety assessments of CEA's facilities

    International Nuclear Information System (INIS)

    The safety assessments of CEA's facilities was made in 2 steps. The first step that was performed end 2011 involved facilities that had priority according to the French Safety Authority among them the Jules Horowitz reactor being built in Cadarache, the Masurca reactor (being upgraded in Cadarache), the Plutonium workshop (being dismantled in Cadarache), the Osiris reactor (that operates in Saclay) and the Phenix reactor (decommissioned at Marcoule). The second step was performed in 2012. The main conclusion is the setting of a hard core of measures concerning equipment and organization that is able to sustain the vital functions of each facility in any accidental situation. Another consequence is the reinforcement of the emergency means (equipment and organization) in the Cadarache site. (A.C.)

  6. CEA programme on gas cooled reactors

    International Nuclear Information System (INIS)

    Future nuclear energy systems studies conducted by the CEA aim at investigating and developing promising technologies for future reactors, fuels and fuel cycles, for nuclear power to play a major part in sustainable energy policies. Reactors and fuel cycles are considered as integral parts of a nuclear system to be optimised as a whole. Major goals assigned to future nuclear energy systems are the following: reinforced economic competitiveness with other electricity generation means, with a special emphasis on reducing the investment cost; enhanced reliability and safety, through an improved management of reactor operation in normal and abnormal plant conditions; minimum production of long lived radioactive waste; resource saving through an effective and flexible use of the available resources of fissile and fertile materials; enhanced resistance to proliferation risks. The three latter goals are essential for the sustainability of nuclear energy in the long term. Additional considerations such as the potentialities for other applications than electricity generation (co-generation, production of hydrogen, sea water desalination) take on an increasing importance. Sustainability goals call for fast neutron spectra (to transmute nuclear waste and to breed fertile fuel) and for recycling actinides from the spent fuel (plutonium and minor actinides). New applications and economic competitiveness call for high temperature technologies (850 deg C), that afford high conversion efficiencies and hence less radioactive waste production and discharged heat. These orientations call for breakthroughs beyond light water reactors. Therefore, as a result of a screening review of candidate technologies, the CEA has selected an innovative concept of high temperature gas cooled reactor with a fast neutron spectrum, robust refractory fuel, direct conversion with a gas turbine, and integrated on-site fuel cycle as a promising system for a sustainable energy development. This objective

  7. Saclay CEA Centre. Environmental assessment 2009

    International Nuclear Information System (INIS)

    This report presents the environmental control organization (sampling places and frequencies) about the Saclay CEA centre, and indicates the authorized levels for liquid and gaseous effluent releases by its installations. It comments the obtained results concerning air quality, water quality (surface and underground waters), bio-indicators (sampling and measurements performed in grasses, fruits, vegetables, milk, and so on, with notably the presence of Tritium of K40), and the assessment of the radiological impact due to annual radioactive releases. The report discusses the evolution of Tritium releases since 1968, and gives an assessment of these releases before 1968 (i.e. before it has been systematically controlled). It comments the new regulation regarding releases and gives a comparison with the releases limits defined in 1978. A brief presentation of the Saclay center environmental policy is given

  8. DISTRIBUCIÓN ACTUAL Y POTENCIAL DE LAS CACTÁCEAS FEROCACTUS HISTRIX, MAMMILLARIA BOMBYCINA Y M. PEREZDELAROSAE EN EL ESTADO DE AGUASCALIENTES, MÉXICO

    OpenAIRE

    Ernestina Meza-Rangel; Felipe Tafoya; Roberto Lindig-Cisneros; Jos\\u00E9 Jes\\u00FAs Sigala-Rodr\\u00EDguez; Eugenio P\\u00E9rez-Molphe-Balch

    2014-01-01

    Las cactáceas en México son un grupo representativo de las zonas áridas que actualmente presenta problemas de conservación debido a la sobreexplotación y el saqueo de los que han sido objeto en todo el país. En este trabajo se reporta la distribución actual de tres especies de cactáceas en el estado de Aguascalientes actualmente sujetas a protección especial según la legislación ambiental federal mexicana (Ferocactus histrix, Mammillaria bombycina y M. perezdelarosae). Se estimó su distribuci...

  9. CEA experimental feedback on sodium loop decommissioning

    International Nuclear Information System (INIS)

    The aim of this paper is to present experimental feedback on sodium loop dismantling techniques at the CEA (The French Atomic Energy Commission) and to offer recommendations for the decommissioning of Fast Reactor secondary sodium loops. This study is based on acquired CEA decommissioning experience which primarily concerns the following: the decommissioning of RAPSODIE (France's first Fast Reactor), the PHENIX reactor secondary loop replacement, the sodium loop decommissioning carried out by the Laboratory of Sodium Technologies and Treatment, and several technical documents. This paper deals with the main results of this survey. First, a comparison of 8 pipe-cutting techniques is made, taking into account speed in cutting, reliability, dissemination, fire risk due to the presence of sodium, cutting depth, and different types of waste (empty pipes, sodium-filled pipes, tanks...). This comparison has led us to recommend the use of an alternative saw or a chain saw rather than the use of the plasma torch or grinder. Different techniques are recommended depending on if they are on-site, initial cuttings or if they are to be carried out in a specially-designed facility referred to hereafter as 'the cutting building'. After the cutting stage, the sodium waste must be processed with water to become an ultimate stable waste. Four treatment processes are compared with different standards : speed, cost, low activity adaptability and 'large sodium quantity' adaptability. Recommendations are also made for reliable storage, and for the general dismantling system organization. Last, calculations are presented concerning a complete dismantling facility prototype capable of treating large amounts and volume of sodium wastes. (author)

  10. Ecotoxicological monitoring at CEA - Centro Experimental Aramar; Monitoramento ecotoxicologico no CEA - Centro Experimental Aramar

    Energy Technology Data Exchange (ETDEWEB)

    Mattiolo, Sandra Regina; Machado, Alessandra Carla Fattori Ergesse [Centro Tecnologico da Marinha em Sao Paulo (CTMSP), Sao Paulo, SP (Brazil)]. E-mail: sandra@ctmsp.mar.mil.br; alessan@ctmsp.mar.mil.br

    2005-07-01

    The environmental preservation has been one of the major targets of the Centro Experimental Aramar (CEA), since its foundation. The research center is located near Ipero, SP, and is maintained by Centro Tecnologico da Marinha em Sao Paulo - CTMSP. An Environmental Monitoring Program is developed with many types of matrices being periodically collected and analysed, including all the gaseous and liquids emissions liberated by the facilities. Besides radiometric and chemical analysis we have been testing bioassays for the effluents to accomplish the new recommendations from governmental agencies. The microcrustacean Daphnia similis has been tested in toxicity assays on liquid effluents and the garden plant Tradescantia pallida has been used to assess the genotoxicity effects from gaseous emissions. The results show that liquid and gaseous emissions from CEA are bellow the regulatory levels. (author)

  11. Carcinoembryonic antigen (CEA) as tumor marker in lung cancer

    DEFF Research Database (Denmark)

    Knudsen, Mie Grunnet; Sorensen, J B

    2012-01-01

    The use of CEA as a prognostic and predictive marker in patients with lung cancer is widely debated. The aim of this review was to evaluate the results from studies made on this subject. Using the search words "CEA", "tumor markers in lung cancer", "prognostic significance", "diagnostic...... significance" and "predictive significance", a search was carried out on PubMed. Exclusion criteria was articles never published in English, articles before 1981 and articles evaluating tumor markers in lung cancer not involving CEA. Initially 217 articles were found, and 34 were left after selecting those...... relevant for the present study. Four of these included both Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) patients, and 31 dealt solely with NSCLC patients. Regarding SCLC no studies showed that serum level of CEA was a prognostic marker for overall survival (OS). The use of CEA...

  12. Report transparency and nuclear safety 2007 CEA Saclay; Rapport transparence et securite nucleaire 2007 CEA Saclay

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Saclay for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially two public consultation on release authorizations and the Neurospin installations, the dismantling of the 49 nuclear installation, the shutdown of the learning reactor ULYSSE are detailed. (A.L.B.)

  13. Report transparency and nuclear safety 2007 CEA Marcoule; Rapport transparence et securite nucleaire 2007 CEA Marcoule

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Marcoule for the year 2007. Since its creation in 1955 the center realizes industrial and scientific activities relative to the civil and military applications of the radioactivity. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the following two base activities are detailed: Atalante and Phenix. (A.L.B.)

  14. 22 CFR 97.5 - Certification of Hague Convention Compliance in an incoming convention case where final adoption...

    Science.gov (United States)

    2010-04-01

    ...) A copy of the certificate issued by a consular officer pursuant to 22 CFR 42.24(j) certifying that... decree, when based upon the certificate issued by a consular officer pursuant to 22 CFR 42.24(j... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Certification of Hague Convention Compliance...

  15. Visiting the theatre: spatial regulation and segregation around theatre halls: Amsterdam and The Hague, 1750-1900

    NARCIS (Netherlands)

    J.H. Furnée

    2013-01-01

    Exploring the socio-spatial practices of "going to the theatre" in its literal sense, this article studies the history of traffic regulation around the major theatres of Amsterdam and The Hague in the period between 1750 and 1900. The article demonstrates that, as urban theatres became increasingly

  16. Detecting child abuse based on parental characteristics: Does The Hague Protocol cause parents to avoid the Emergency Department?

    NARCIS (Netherlands)

    Diderich, H.M.; Fekkes, M.; Dechesne, M.; Buitendijk, S.E.; Oudesluys-Murphy, A.M.

    2015-01-01

    Objectives: The Hague Protocol is used by professionals at the adult Emergency Departments (ED) in The Netherlands to detect child abuse based on three parental characteristics: (1) domestic violence, (2) substance abuse or (3) suicide attempt or self-harm. After detection, a referral is made to the

  17. The organisation of criticality hazard prevention at the CEA

    International Nuclear Information System (INIS)

    This paper deals with the organisation of criticality hazard prevention at the French Atomic Energy Commission (CEA). This new organization has been experimented since the end of year 2000. During the first semester of year 2002, the CEA nuclear inspection team, who is in charge of the control function at the CEA general administration level, has performed an inquiry to check the effectiveness of the new organization. The conclusions of this inquiry are very positive; a few recommendations are now taken in to account to further improve the efficiency of this organization. (J.P.N.)

  18. CEA nuclear energy Directorate - Activity report 2012

    International Nuclear Information System (INIS)

    After an overview of the activities of the Directorate at the international level, of its scientific activities, and of the consideration given to quality, and a presentation of the transverse program on advanced materials, this report proposes presentations of activities in different domains: future nuclear industrial systems (reactors of 4. generation, back-end of the future cycle, sustainable management of nuclear materials, fundamental scientific and technological research), optimization of the present industrial nuclear activity (reactors of 2. and 3. generation, front-end and back-end of the fuel cycle), the main tools for nuclear development (numerical simulation, the Jules Horowitz reactor), valorisation, economic support of Haute-Marne and Meuse territories (the Syndiese project), nuclear dismantling and decontamination (dismantling projects, projects and works in Fontenay-aux-Roses, Grenoble and Saclay, waste and material flow management, nuclear service facilities, transports). It also presents the activities of some specific CEA centres like Marcoule (R and D in fuel cycle), Cadarache (future energies) and Saclay (nuclear sciences and simulation of reactors and fuel cycle)

  19. Metamorphosis of Shell's office buildings in The Hague, Netherlands; Metamorfose Shell Den Haag

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, G.F.A. [Valstar Simonis, Apeldoorn (Netherlands); Van Mierlo, W.J.M. [Shell, Den Haag (Netherlands)

    2008-07-15

    In a project to renovate the Shell office buildings in The Hague, Netherlands, the new buildings are served by a new power plant based on a heat pump and an underground thermal storage system. Use of a heating curve in the high-temperature heating system of the renovated building sections made it possible to create a link between the new low-temperature heating system and the existing high-temperature heating system. A similar link was created for cooling. [Dutch] Bij de herstructurering van het gebouwencomplex van Shell in Den Haag is voor de nieuwe gebouwen een energiecentrale met een warmtepomp en ondergronds energieopslagsysteem gerealiseerd. Door gebruik te maken van een stooklijn in het hooggestookte verwarmingssysteem van de gerenoveerde bouwdelen, is een koppeling aangebracht tussen het nieuwe Iaagtemperatuur verwarmingssysteem en het bestaande hooggestookte verwarmingssysteem. Ook voor de koeling is een dergelijke koppeling gemaakt.

  20. THE PROTECTION OF CULTURAL GOODS FROM THE ROERICH PACT TO THE HAGUE CONVENTION

    Directory of Open Access Journals (Sweden)

    MARIAN MIHĂILĂ

    2013-05-01

    Full Text Available The study premises and objectives: The idea found at the basis of the discovery of a real value of cultural goods is underlined by the knowledge of their origins and history and of an environmental frame in which these have been produced. This theory could also be applied in regulations provided with certain newly introduced elements as: the absolute interdiction of thefts; the interdiction of destruction and execution of enemy property; the warning of before a terrestrial bombing with naval forces of ports, cities, villages, buildings or houses which are not defended The purpose on this paper is based on the following question: “Which of the gaps of humanitarian international law regarding cultural goods are surfacing?” The research models used are: the interpretative method, the structuralist-systematic method necessary for the knowledge of rules of organization and functioning of law as a system of social organization; the epistemological method, with an important role in the verification of an authentic meaning, fully manifesting the exigency regarding the protection of cultural property. The result of the study is obtained by offering an answer which as argued in this paper, concluding on one side that the discrepancies appeared between provisions (or dispositions of the Hague Convention of 1907 and the events of the First World War have led to an improved idea and to a completion of these norms. Conclusions: The preoccupation for the protection of cultural goods, of the people’s cultural patrimony, thus continues, even if, despite all acts adopted, we observe that certain states destroy willingly the treasures of other peoples. We have thus reached the conclusion that more drastic measures must be adopted more severe sanctions must be applied to states that neglect the norms of humanitarian international law and the existent gaps must be eliminated. For this reason the Second Protocol of The Hague Convention of 1954 has been promoted

  1. Las Podocarpáceas de los bosques montanos del noroccidente peruano

    Directory of Open Access Journals (Sweden)

    Edgar E. Vicuña-Miñano

    2013-05-01

    Full Text Available Los bosques montanos del noroccidente peruano son formaciones vegetales que presentan una alta diversidad y endemismos. Lamentablemente, en muchos lugares están sujetos a procesos acelerados de deterioro por la deforestación y colonización, aspecto que los convierte en uno de los ecosistemas más amenazados por el hombre. Lo que ahora queda de estos bosques, alguna vez extensos, son sólo fragmentos. Los bosques montanos relictos son ecosistemas ubicados por encima de los 1000 m de altitud, en la Vertiente Occidental de los Andes. Es en estos bosques, donde se pueden encontrar especies de coníferas nativas de nuestro país, pertenecientes a la familia Podocarpaceae. Estas especies juegan un rol de suma importancia en la dinámica de estos ecosistemas tan frágiles; no obstante, debido a la calidad de sus maderas, están siendo extraídas de manera alarmante. En el noroccidente peruano existen zonas de bosques homogéneos de Podocarpáceas tal es el caso del bosque de Cachil en la provincia de Contumazá, bosque de TongodQuellahorco en la provincia de San Miguel (en los cuales predomina la especie Podocarpus oleifolius y los bosques de San Ignacio en Cajamarca, en los que reportamos cinco especies de Podocarpáceas distribuidas en tres géneros: Podocarpus (P. oleifolius, P. macrostachys, P sprucei, Prumnopitys (P. harmsiana y Nageia (N. rospigliosii, las cuales representan el 50% del total de especies reportadas para el Perú.

  2. Carcinoembryonic antigen (CEA) dynamics in stomach cancer patients receiving cryotherapy

    International Nuclear Information System (INIS)

    Radioimmunologic assays of blood serum carcinoembryonic antigen (CEA) level were conducted at major stages of treatment of gastric cancer by subtotal stomach resection and gastrectomy with preliminary cryotreatment and thawing of tumor. A short-term rise in CEA level occurred in 53.9 % of cases 3-4 days after combined therapy. A decrease in CEA concentration at discharge from hospital as compared with preoperative level and that registered 3-4 days after operation was observed in 50 and 75 % of cases of combined therapy, respectively, and 47.5 and 37.5 % of controls (surgery without cryotreatment). There was nocorrelation between cryotreatment and changes in CEA level in gastric ulcer patients

  3. Balance 2003 of the risks control at the Cea

    International Nuclear Information System (INIS)

    As a research center on the energy, the information and health technologies and the defense, the Cea activities are indissociable from the risk control notion. To organize the risks management, the Cea decided to create in july 2003 a special pole of risks control and management. This presentation is based on some major topics of the risks control: the environmental impact control, the occupational risks control, the installations safety control and the hazardous matter transport control. (A.L.B.)

  4. Bivalent fragment of the ior-CEA1 antibody. A challenge to the positive CEA tumors radioimmunotherapy

    International Nuclear Information System (INIS)

    The directed radiotherapy of the solid tumors with fragments recombinants of radiolabelled antibodies is a topic of current investigation, so much at preclinical level as clinical. This work describes the preclinical characterization of a new fragment type diabody of the AcMo ior CEA1 that has been labelled with 131 I for their use in the diagnosis and the therapy of CEA positive tumors. The radiolabelling methodology used allows the incorporation of more than 90% of the radio iodine to the molecule without committing the capacity of recognition of its antigen significantly. The combination of the favourable properties pharmacy kinetic and high selective accumulation in the tumor, they make of the diabody anti CEA an appropriate candidate for the radioimmunodiagnosis and the radioimmunotherapy of tumors that expresses CEA (Author)

  5. Colecta y establecimiento de anonáceas en El Salvador

    Directory of Open Access Journals (Sweden)

    Eduardo Cruz

    2000-01-01

    Full Text Available El Centro Nacional de Tecnología Agropecuaria y Forestal (CENTA, a través de la Unidad de Recursos Fitogenéticos, inició en 1998 un diagnóstico geográfico de especies de anonáceas, con el objetivo de explorar, recolectar, caracterizar y establecer colecciones de campo en las Estaciones Experimentales. Las características evaluadas para frutos fueron: peso, largo y diámetro, número de semillas, textura de cáscara y pulpa; forma de fruto y cárpelos, daño por plagas y enfermedades y un análisis bromatológico. Como resultado de este trabajo se estableció la colección de anonáceas con las siguientes especies: squamosa, cherimola, reticulata, muricata, purpurea, diversifolia, holosericea y glabra. En la caracterización morfológica preliminar Annona muricata obtuvo un promedio de 175 semillas/fruto y 1,319 g en peso del fruto. A. cherimola con pulpa muy arenosa y carpelos no prominentes. A. squamosa con pulpa dulce, blanca y cárpelos muy prominentes. De la caracterización bromatológica se determinó que Annona muricata dio contenidos de humedad superiores a 82,8%; fibra cruda de 1,84% y fósforo con 367 ppm. En Annona diversifolia con menor grasa 0,01%. La mayor incidencia por plagas en frutos y semillas fue causado por el perforador Bephrateloides sp. La antracnosis (Colletotrichum sp. en frutos y follaje fue la enfermedad más observada

  6. Purex process improvements for the UP3 spent fuel reprocessing plant at La Hague, France

    International Nuclear Information System (INIS)

    The UP3 reprocessing plant commissioned for active operation in November 1989 features numerous innovations both for the process flowsheet and the associated equipment. These innovations yielded positive results following initial active testing and are of considerable interest for solvent extraction specialists. This paper describes the main improvements introduced for the extraction cycles used to separate and purify uranium and plutonium. Specifically, these improvements include: adaptation of the first extraction cycle flowsheet for technetium decontamination and tritium confinement; solvent purification process based on distillation, a key element in the solvent system; flowsheets adapted for maximum recycling of liquid organic and mineral streams (solvent or nitric acid); use of annular or cylindrical pulsed columns with high-efficiency packing

  7. ALPHA WASTE MINIMIZATION IN TERMS OF VOLUME AND RADIOACTIVITY AT COGEMA'S MELOX AND LA HAGUE PLANTS

    International Nuclear Information System (INIS)

    This paper describes the management of alpha waste that cannot be stored in surface repositories under current French regulations. The aim of the paper is to provide an overview of COGEMA's Integrated Waste Management Strategy. The topics discussed include primary waste minimization, from facility design to operating feedback; primary waste management by the plant operator, including waste characterization; waste treatment options that led to building waste treatment industrial facilities for plutonium decontamination, compaction and cement solidification; and optimization of industrial tools, which is strongly influenced by safety and financial considerations

  8. On line measurements and process control for La Hague UP3

    International Nuclear Information System (INIS)

    A reprocessing plant is allowed of specialized work-rooms in varying functions: fuel receipt and storage, mechanical treatment, chemical dissolution, purification, waste treatment, waste conditioning. At the different reprocessing stages, it is necessary to know a big number of parameters to assure that each work-room works in a satisfactory condition with respect to safety, performances and nuclear matter management. In this paper the author gives an overview of the control methods used in UP3

  9. Operational safety in plutonium processing workshops at the La Hague site

    International Nuclear Information System (INIS)

    To keep under control the nuclear and non-nuclear hazards of plutonium treatment and handling, and to implement the corporate policy to reduce the doses to personnel in compliance with ALARA, it has been necessary to document operating rules. They take into account the following items: Operation of the facility: The facility is operated in compliance with documents containing both operating instructions and definition of the limits of the normal operation area (including the evolution of the operating parameters). A method to manage the non-conformities with those requirements is always implemented when a barrier of the authorized area has been passed. Each member of the operating team is trained and the documents are explained. Maintenance and periodic survey: The good operation of the facility requires to implement maintenance and survey plans, complemented with the experience got back during operation. The periodic cleaning of the enclosures containing plutonium is an example of an item of those plans. Plant modification and refurbishment: From design to decommissioning, the facility has to be improved and enhanced. All the plans for that purpose are checked before implementation in order to verify that the safety of the workshop is by no means weakened, and that no unexpected hazard is to take place during the completion of the work. From the beginning of the project a dosimetric target is assigned. After completion of the work, the target is compared with the cumulated dose of the project, in order to find out the appropriate conclusions. The implementation of that method in our plutonium treatment facilities has provided quite good results concerning both doses to personnel and operation safety. (author)

  10. Measurement campaign at La Hague by European mobile laboratories: a technical and sociological experiment

    International Nuclear Information System (INIS)

    The multidisciplinary expert investigation by the Nord-Cotentin Radioecology Group provided results that were published in 1999 and essentially related to: - the inventory of the radioactive releases from local nuclear facilities, - critical review of measurements made in the environment, - models of transfer of radionuclides through the environment, - estimation of doses and associated leukaemia risks. In view of the unavoidable uncertainties of a retrospective study, the Group developed an evolving system for integrating new knowledge and results. The initiative of the local 'Angry Mothers' to organise an international measurement campaign in the north of the Cotentin peninsula is perfectly consistent with this approach. The goal is to establish a radiological baseline corresponding to the existing situation by means of the following investigations, depending on the possibilities of the laboratories involved: - in-situ gamma spectrometry measurements, - environmental sample measurements, - measurements by inhabitants. (orig.)

  11. The interpretation and application of article 13(b) of the Hague Convention on the Civil Aspects of International Child Abduction

    OpenAIRE

    Robinson, Jacobus Abraham; Weideman, Jeanette

    2011-01-01

    This article examines how courts in the UK, the USA and South Africa apply and interpret article 13(b) of the Hague Convention on the Civil Aspects of International Child Abduction. Courts in the UK have always adopted a very narrow interpretation and application of this defence. Even domestic violence victims who flee with their children to escape domestic violence have had difficulty invoking this defence successfully. This very narrow interpretation is due to the fact that English courts a...

  12. Fusion technology. Annual report of the. Association Cea/EURATOM

    International Nuclear Information System (INIS)

    In 1996, the French EURATOM-CEA Association made significant contributions to the European technology programme. This work is compiled in this report as follows: the ITER CEA activities and related developments are described in the first section; blankets and material developments for DEMO, long term safety studies are summarised in the second part; the Underlying Technology activities are compiled in the third part of this report. In each section, the tasks are sorted out to respect the European presentation. For an easy reading, appendix 4 gives the list of tasks in alphabetical order with a page reference list. The CEA is in charge of the French Technology programme. Three specific organizational directions of the CEA, located on four sites (see appendix 5) are involves in this programme: Advanced Technologies Direction (DTA), for Material task; Nuclear Reactors Direction (DRN), for Blanket design, Neutronic problems, Safety tasks; Physical Sciences Direction (DSM) uses the competence of the Tore Supra team in the Magnet design and plasma Facing Component field. The CEA programme is completed by collaborations with Technicatome, COMEX-Nucleaire and Ecole Polytechnique. The breakdown of the programme by Directions is presented in figure 1. The allocation of tasks is given in appendix 2 and in appendix 3, the related publications. (author)

  13. Fitoplancton del Parque Nacional Las Tablas de Daimiel. II. Las cianofíceas, los dinoflagelados, las criptofíceas, las crisofíceas y las xantofíceas

    Directory of Open Access Journals (Sweden)

    Rojo, Carmen

    1999-12-01

    Full Text Available Las Tablas de Daimiel National Park is a semiarid wetland that exhibits a high biodiversity but is suffering an inexorable eutrophication process. The study of the phytoplankton in this wetland is interesting because of its hydrological fluctuations (drought period until 1996 and its trophic condition. This papers shows the taxonomy, dynamic, and ecology of microalgae in five áreas of the Park from 1996 to 1998, which allow comparisons to be made between the present state and the 1992-1993 period. Twelve taxa of Cyanophyta, 4 of Dynophyceae, 8 of Cryptophyceae, 5 of Chrysophyceae and one of Xanthophyceae were found. Almost all species have been already cited in Spain and are typical for eutrophic environments. Cyanophyceae and Cryptophyceae were the most important groups (Planktothrix agardhii, Anabaenopsis elenkinii, Cryptomonas erosa as the most common algae. Moreover, oscillatorial Cyanophyceae (in 1992 have been replaced by N-fixing nostocal ones, related to the high level of pollution found in recent years.El Parque Nacional Las Tablas de Daimiel es un humedal semiárido, importante reserva de biodiversidad que, sin embargo, está sufriendo un inexorable proceso de eutrofización. Su estado trófico, así como los cambios hidrológicos (sequía hasta 1996, hacen especialmente interesante el estudio de su microflora. Por ello, se ha llevado a cabo este trabajo sobre las poblaciones fitoplanctónicas en cinco puntos del Parque desde 1996 a 1998, que permite además la comparación con su estado en 1992-1993. Se encontraron 12 táxones de Cyanophyta, 4 de Dynophyceae, 8 de Cryptophyceae, 5 de Chrysophyceae y uno de Xanthophyceae. Casi todas las especies están citadas en España y son propias de ambientes eutróficos. Los grupos mejor representados fueron las cianobacterias y criptofíceas (Planktothrix agardhii, Anabaenopsis elenkinii y Cryptomonas erosa fueron las especies más conspicuas. Además, se observa un cambio de cianobacterias

  14. Spanish pre-university students' use of English: CEA results from the University Entrance Examination

    Directory of Open Access Journals (Sweden)

    María Belén Díez Bedmar

    2011-12-01

    Full Text Available In this paper an updated overview of the main errors that Spanish students make when writing the English exam in the University Entrance Examination is provided. To do so, a Computer-aided Error Analysis (CEA (Dagneaux, Denness & Granger, 1998 was conducted on a representative sample of the students who took the exam in June 2008 in Jaén, and wrote a composition on the same topic. The use of the most widely-used error taxonomy, the Error Tagging Manual version 1.1. (Dagneaux, Denness, Granger & Meunier, 1996, and the analysis of the results by means of descriptive statistics foster the possibility to replicate this study and move forward in the description of the students’ written command in the foreign language at this stage. The comparison of the findings obtained in this study and those from previous (CEAs on the English exam reveals that some common tendencies may be shown.Este artículo aporta una visión general actualizada de los errores más importantes que los alumnos españoles cometen cuando escriben el examen de inglés de la Prueba de Acceso a la Universidad. Con este fin, se realizó un Análisis de Errores Informatizado (Dagneaux, Denness & Granger, 1998 en una muestra representativa de los estudiantes que realizaron el examen en Junio de 2008 en la Universidad de Jaén, y que escribieron sobre un mismo tema. El uso de la taxonomía de errores más usada, el Error Tagging Manual version 1.1. (Dagneaux, Denness, Granger & Meunier, 1996, y de la estadística descriptiva para analizar los resultados, favorecen la réplica de este estudio y la posibilidad de mejorar la descripción de la destreza escrita en la lengua extranjera. La comparación de los resultados en este artículo y otros Análisis de Errores (Informatizados previos muestran que se pueden exponer algunas tendencias comunes.

  15. After the Hague, Bonn and Marrakech: uncertainties on the future international market of emission permits

    International Nuclear Information System (INIS)

    The purpose of this article is to present an economic assessment, step by step, of the successive developments of the negotiation on weather changes since the Kyoto protocol in 1997 until the agreement achieved in Marrakech during the seventh Conference of the Parties (COP 7) in November 2001. The analysis covers the international market of emission rights, a key mechanism of the Protocol, the purpose of which is to facilitate the Parties' compliance with their undertakings, by introducing flexibility to improve the economic efficiency of emission reduction. However, it now appears that despite the Marrakech agreement in November 2001, the system is weakened by the withdrawal of the USA decided by President G.W. Bush in March 2001, following COP 6 in The Hague, and by a potential excess of permits due to the economic recession of transition countries since the early nineties (hot air). As things stands, the establishment of the market between the countries taking part in the process will undoubtedly require some management of this hot air between transition countries (Eastern Europe and Ex USSR) and the other Parties of appendix B still involved in the process. The uncertainties weighing on the future market of emission permits strengthen the strategic significance of the implementation of effective reduction policies within those regions and particularly within Europe. (authors)

  16. 2nd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Mulder, Bob; Choukroun, Daniel; Kampen, Erik-Jan; Visser, Coen; Looye, Gertjan

    2013-01-01

    Following the successful 1st CEAS (Council of European Aerospace Societies) Specialist Conference on Guidance, Navigation and Control (CEAS EuroGNC) held in Munich, Germany in 2011, Delft University of Technology happily accepted the invitation of organizing the 2nd  CEAS EuroGNC in Delft, The Netherlands in 2013. The goal of the conference is to promote new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems using on-board sensing, computing and systems. A great push for new developments in GNC are the ever higher safety and sustainability requirements in aviation. Impressive progress was made in new research fields such as sensor and actuator fault detection and diagnosis, reconfigurable and fault tolerant flight control, online safe flight envelop prediction and protection, online global aerodynamic model identification, online global optimization and flight upset recovery. All of these challenges de...

  17. CEA's Implication in Nuclear Security Events Detection and Response

    International Nuclear Information System (INIS)

    In France, CEA1 is a key player in research, development and technical innovation in three main areas: energy, heath and information technologies, defence and global security. For example CEA has developed a multitude of technologies to fight nuclear, radiological, biological and chemical threats, as well as equipment to diagnose and assess radiological or nuclear improvised explosive devices. CEA is also involved in all technical aspects dealing with detection of and response to a nuclear security event. CEA is a major player in the operational response to a terrorist or criminal act involving Nuclear or Radiological material. He operates under DCI-IT2, a dedicated national structure which includes the necessary personnel to neutralize the threat. CEA is also in charge of advice and assist competent authorities in the management of a nuclear security event. The paper clarify CEA’s implication in detection of and response to a nuclear security event and position in the French organization for operational response, elements of the intervention strategy - research to neutralize the threat - as well as examples of technical achievements that most are made subject to transfer to an industrial. In the context of the common declaration from France-United Kingdom-United States of America governments at Seoul summit in March 2012 to engage to further strengthen worldwide preparedness to contend with the threat of nuclear terrorism, France has capability to response to a nuclear threat device. This document will support this declaration and will give examples of CEA involvement in Nuclear Security system and measures. (author)

  18. Decision no. 2011-DC-0224 of the French nuclear safety authority from May 5, 2011, ordering the French atomic energy and alternative energies commission (CEA) to proceed to a complementary safety evaluation of some of its basic nuclear facilities in the eyes of the Fukushima Daiichi nuclear power plant accident; Decision no. 2011-DC-0224 de l'Autorite de surete nucleaire du 5 mai 2011 prescrivant au Commissariat a l'Energie Atomique et aux energies alternatives (CEA) de proceder a une evaluation complementaire de la surete de certaines de ses installations nucleaires de base au regard de l'accident survenu a la centrale nucleaire de Fukushima Daiichi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    As a consequence of the accident of the Fukushima Daiichi nuclear power plant (Japan), the French Prime Minister entrusted the French nuclear safety authority (ASN) with the mission to carry out a safety analysis re-evaluation of the French nuclear facilities, and in particular the nuclear power plants. A decision has been addressed by the ASN to each nuclear operator with the specifications of this safety re-evaluation analysis and the list of facilities in concern. This document is the decision addressed to the French atomic energy commission (CEA). (J.S.)

  19. CEA 2011, a look back at a year of research

    International Nuclear Information System (INIS)

    For this year 2011, marked by the Fukushima accident, the goal is improved safety. This is a key issue being addressed by CEA, while at the same time boosting its R and D on low-carbon energies, defense and security, Health technologies, information technologies and very large research Infrastructures. With more than 650 priority patents filed in 2011, CEA maintains its position as the leading French research organization. CEA stands in 4. place among the European research organizations, in terms of the number of projects (535, including 70 that it coordinates) and financing obtained (nearly euros 55 M) under the European Commission's FP7 framework programme. CEA's civil programs are 30% funded from external revenues (partner companies, national incentive funds, local authorities and European Union), 49% from the Government and, finally, 21% from two funds dedicated to clean-up of civil and defense facilities. Of the euros 1, 391 M devoted to low-carbon energies, research into the new energy technologies and nuclear systems of the future each received a budget of euros 151 M in 2011. CEA plays a key role in the European Energy Research Alliance, as a founding member, a member of the executive committee and a member of the secretariat. It is France's representative. EERA has launched 13 joint programs, including 6 in 2011. It pools the research efforts of more than 150 institutes and universities, with more than 2, 000 staff employed full-time. CEA is present in 8 programs, with 100 full-time staff, in other words 5% of the total partner commitment. This special issue of 'Defis du CEA' journal deals with the main results of the researches carried out in 2011 at the CEA. Contents: 1 - Facts and figures 2011: Intellectual Property, European Financing, Budget, Nuclear Safety, European Research Programs, International Relations, International Collaboration, Spin-off, Scientific Excellence, Training; 2 - Low-carbon energies: Biofuels, Solar Photovoltaic, Nuclear, Energy

  20. Report transparency and nuclear safety 2007 CEA Grenoble

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Grenoble for the year 2007. Since 2002 the Passage project aims to realize the decontamination and the dismantling of old nuclear installations of the CEA Grenoble. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the year 2007 saw two main steps of the Passage project: the decommissioning of the Siloette reactor, a public consultation about the Lama laboratory dismantling. (A.L.B.)

  1. The CEA-industrie Group. Report for 1986

    International Nuclear Information System (INIS)

    From the end of 1983, the whole affiliates and participations of CEA are hept by CEA-industry. The group activity is principally in the nuclear field. Cogema and the whole fuel cycle, construction, maintenance, improvement of nuclear power plants, research reactors and naval propulsion boilers and the sector Power plants and nuclear services (Framatome, Technicatome, Intercontrole, Stmi, principally). A non-nuclear sector comes from new techniques or activities developed for the nuclear needs: computer science (CISI), biomedical field (ORIS-industrie), different activities such as ultrafiltration or robotics-productics

  2. Remote manipulators and mobile robots in the CEA

    International Nuclear Information System (INIS)

    Thanks to Jean Vertut's works in the seventies, the CEA has been a pioneer in nuclear remote manipulation and mobile robots conception and has developed innovating systems in response to industry request. During the nineties, improvements in computer control systems have led to the realization of functional demonstrators. In 1995, advances in technology have allowed to consider the first industrial applications of nuclear remote manipulators and robots. This paper gives a review of the development and research works carried out by the CEA in this domain since the seventies, and also some future prospects. (J.S.). 10 figs

  3. CEA Bolometer Arrays: the First Year in Space

    OpenAIRE

    Billot, Nicolas; Sauvage, M.; RODRIGUEZ, L.; Horeau, B.; Kiss, C.; Aussel, H.; Okumura, K; O. Boulade; Altieri, B.; Poglitsch, A.; Agnese, P.

    2010-01-01

    The CEA/LETI and CEA/SAp started the development of far-infrared filled bolometer arrays for space applications over a decade ago. The unique design of these detectors makes possible the assembling of large focal planes comprising thousands of bolometers running at 300 mK with very low power dissipation. Ten arrays of 16x16 pixels were thoroughly tested on the ground, and integrated in the Herschel/PACS instrument before launch in May 2009. These detectors have been successfully commissioned ...

  4. The opening of the CEA to the general public

    International Nuclear Information System (INIS)

    Full text: The relationships between science and society have evolved considerably over the past years, just like the perception of the nuclear industry in the French public opinion. Recent psychosociological surveys show that only half of the French population is familiar with the CEA and that the public would like to obtain new elements of judgment in order to be able to develop a direct appreciation of the activities of a research organization such as the Atomic Energy Commission. It is essential to meet the public's expectations, to keep it properly informed of the CEA's research activities, and to help it understand the relevance of the results obtained and the solutions offered to decision-makers, i.e. industrialists and public authorities. One way to answer the public opinion's questions and to meet its expectations is to allow a rowing number of visitors to see who we are, what we study in our laboratories, and how we work to contribute to scientific progress and to the diffusion of technology, in a manner that is useful to society as a whole. This describes the spirit and the objective that governed the very idea and elaboration of the program entitled 'Opening of the CEA to the general public'. This operation consists not only in having communication specialists guide visitors throughout the facilities and equipment of the CEA, but also in encouraging researchers and groups of visitors to meet in the laboratories. A 'CEA - communication' network is under construction. It already has nearly 600 members. Communication is considered to be a real calling that falls within the scope of the CEA's strategy, and the work accomplished in this respect is recognized to the same extent as research. To this end, a charter for the CEA - communication network will be signed by every contributor and manager. A training scheme focused on public speaking and scientific vulgarization was initiated. 50 members of the network have already been trained, and 250 will be in 1999

  5. How Packaging Fleet Renewal Fits French CEA Programs

    International Nuclear Information System (INIS)

    CEA's (French Atomic Energy Agency) packaging fleet is dedicated to transportation of test irradiated fuels, of research reactors fuels, of navy propulsion fuels, and of waste coming from and to nuclear plants or facilities. This fleet encompasses more than 30 types of casks ranging from 5 to 30 tons, with either recent designs or other dating back to the seventies. A study has been launched in order to perform a global analysis of the life expectancy of the existing CEA and COGEMA Logistics cask fleets with respect to a 2015 target, in order to anticipate its renewal, while limiting the number of type of cask. Key elements like periodical evolutions of design and transport regulations, lessons learnt of existing casks (design, approval and extensions, operational feedback, maintenance and dismantling) are taken into account in order to ensure compliance and availability of the fleet. Moreover, from design to cask delivery, including regulatory tests, safety analysis report/ CoC, and manufacturing, 3 to 5 years is needed. Therefore cask development should be taken into account earlier of invest and research's programs. The paper will address the current life expectancy study of CEA and COGEMA Logistics packaging fleet, based on lessons learnt and regulation evolution and on general R and D plans by user facilities. It will show how a comprehensive optimized fleet is made available to CEA and other customers. Such a fleet combines optimized investment and uses, thus entailing synergies for well-mastered costs of transports. (authors)

  6. Behaviour of heavy water in nuclear reactors of the CEA

    International Nuclear Information System (INIS)

    In the two heavy water reactors of the CEA: Zoe and P-2, we do: A) the supervision of the isotopic composition of the heavy water; B) the supervision of gases released by the decomposition of the heavy water under radiation, and to their recombination; C) periodic analyses of impurities. (M.B.)

  7. Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene

    International Nuclear Information System (INIS)

    Gastric carcinoma is one of the most frequent cancers worldwide. Patients with gastric cancer at an advanced disease stage have a poor prognosis, due to the limited efficacy of available therapies. Therefore, the development of new therapies, like immunotherapy for the treatment of gastric cancer is of utmost importance. Since the usability of existing preclinical models for the evaluation of immunotherapies for gastric adenocarcinomas is limited, the goal of the present study was to establish murine in vivo models which allow the stepwise improvement of immunotherapies for gastric cancer. Since no murine gastric adenocarcinoma cell lines are available we established four cell lines (424GC, mGC3, mGC5, mGC8) from spontaneously developing tumors of CEA424/SV40 T antigen (CEA424/Tag) mice and three cell lines derived from double-transgenic offsprings of CEA424/Tag mice mated with human carcinoembryonic antigen (CEA)-transgenic (CEA424/Tag-CEA) mice (mGC2CEA, mGC4CEA, mGC11CEA). CEA424/Tag is a transgenic C57BL/6 mouse strain harboring the Tag under the control of a -424/-8 bp CEA gene promoter which leads to the development of invasive adenocarcinoma in the glandular stomach. Tumor cell lines established from CEA424/Tag-CEA mice express the well defined tumor antigen CEA under the control of its natural regulatory elements. The epithelial origin of the tumor cells was proven by morphological criteria including the presence of mucin within the cells and the expression of the cell adhesion molecules EpCAM and CEACAM1. All cell lines consistently express the transgenes CEA and/or Tag and MHC class I molecules leading to their susceptibility to lysis by Tag-specific CTL in vitro. Despite the presentation of CTL-epitopes derived from the transgene products the tumor cell lines were tumorigenic when grafted into C57BL/6, CEA424/Tag or CEA424/Tag-CEA-transgenic hosts and no significant differences in tumor take and tumor growth were observed in the different hosts. Although

  8. Disolución y génesis del karst en rocas carbonáticas y rocas silíceas : un estudio comparado.

    OpenAIRE

    GALAN, Carlos

    1991-01-01

    Se describen los mecanismos físicos y químicos que   intervienen en la formación del karst en rocas silíceas y   carbonáticas. Los modelados resultantes son comparados. Se   analizan los factores hidrogeológicos, se cuantifica el trabajo   de excavación y se discute la edad de las formas.

  9. Inapplicability of CEA-7 as a canine bone marrow transplantation marker

    International Nuclear Information System (INIS)

    Procedures are described for histocompatibility matching, erythrocyte typing, and CEA-7 serum substance assay. Results of CEA-7 serum substance assays in CEA-7 positive recipients are shown by means of a graph. After lethal total body irradiation, the CEA-7 substance was demonstrable in the recipients' serum for only 7 to 10 days, with disappearance of the substance from the serum for an equivalent period of time and its reappearance thereafter

  10. The part of CEA as informations emitting organism towards the elected circle

    International Nuclear Information System (INIS)

    This document deals with the CEA (Commissariat a l'Energie Atomique) as an organisation emitting information towards politicians. The CEA is a public, scientific and industrial institution. Its main mission is to develop the mastery of the atom in the field of research, health, energy and defense. Lots of political bodies have some contacts with the CEA. A good communication between politicians and the CEA is therefore a must, as it is explained in this document. (TEC)

  11. Annual report of the Association EURATOM/Cea

    International Nuclear Information System (INIS)

    This annual report presents research activities, which have been performed in 2002 by the French EURATOM-Cea association in the frame of the European technology program. The first section describes EFDA (European fusion development agreement) activities and related developments carried out by the association. The second one is dedicated to the underlying technology program and finally the third one presents the inertial confinement fusion activities. In each section the tasks are sorted out according to the EFDA main fields: physics (heating and current drive, remote participation, diagnostics), vessel/in-vessel (vessel/blanket, plasma facing components, remote handling), magnet, tritium breeding and materials (water cooled lithium lead blanket, helium cooled pebble bed blanket, helium cooled lithium lead blanket, reduced activation ferritic martensitic steels, advanced materials, neutron source, fuel cycle), safety and environment, system studies (power plant conceptual studies, socio-economic studies) and JET technology activities. The EURATOM-Cea association is involved in all these studies

  12. 2011 reporting of the risk handling at CEA

    International Nuclear Information System (INIS)

    In 2011 CEA reported 100 events to the Authority for Nuclear Safety (ASN). 93 were graded 0 on the INES scale and 7 were graded 1. None of them had a significant impact on the staff health and the environment. 25% of these events concerned delays in the controls of safety equipment. In 2011 CEA had to manage several situations that led to a response of its crisis center: 1) the explosion of an oven belonging to the Socodei-Centraco company situated near the Marcoule Center, 2) the discovery of about 500 grenades from the first world war during digging out works in the Grenoble Center, 3) flooding due to heavy rains in the Cadarache Center, and 4) an intrusion attempt at the Cadarache Center. (A.C.)

  13. Overview of CEA research in the field of radionuclides migration

    International Nuclear Information System (INIS)

    This report presents a synthetic status of the researches conducted within the Nuclear Energy Division (CEA/DEN) in the field of radionuclides migration in three specific areas which have been chosen for their representativeness and potential impact: the migration of RN in PWR reactors, the migration of RN from a deep geological repository and the migration processes in the surface environments. In addition, some status is given about more generic research which is conducted in the field of RN speciation in the aqueous phase and at the interfaces and regarding chemistry / transport couplings. Additional information about the human and technical means involved in these fields of research in CEA/DEN is finally given in the Appendix. (authors)

  14. Physical protection of nuclear materials and facilities in CEA

    International Nuclear Information System (INIS)

    Full text: CEA (Commissariat a l'Energie Atomique), as nuclear operator, is responsible for the control and protection of their nuclear materials. Inside CEA, DCS (Central Security Division) is in charge of the security matters, DCS defines the CEA strategy in this field, especially in physical protection. The paper will present the physical protection strategy of CEA. DCS defines the rules and methods; the operators have to apply in order to fulfill the security objectives of CEA. CEA has to provide the regulatory authority with documents proving that it is in accordance with the requirements of the 25th July 1980 law and 12th May 1981 decree. It has to implement all the necessary means in order to achieve the results requested by the regulatory authority. All these arrangements are described in the 'license and control file'. This file should specify the facility safeguards and physical protection system. Accounting measures are also described. In this file, the petitioner has to justify its capacity for holding nuclear materials and for exercising authorized activities on them. So the organization and the installed means have to be described in this authorization file. For physical protection, containment, surveillance and physical protection measures are presented: Containment measures must prevent the unauthorized or unjustified movements of nuclear material in the framework of the authorized activities; Surveillance measures must guarantee the integrity of the containment, check that no material is exiting by an abnormal channel; Physical protection measures for the materials, the premises and the facilities are intended to protect them against malevolent actions by means of security systems. The Central Security Division has established guidelines to provide guidance to the nuclear materials holders in writing such files. Each holding unit has to establish a 'license and control file' and each CEA site establishes a 'site license and control file

  15. Physical protection of nuclear materials and facilities in CEA

    International Nuclear Information System (INIS)

    CEA (Commissariat a l'Energie Atomique), as nuclear operator, is responsible for the control and protection of their nuclear materials. Inside CEA, DCS (Central Security Division) is in charge of the security matters, DCS defines the CEA strategy in this field, especially in physical protection. The paper will present the physical protection strategy of CEA. DCS defines the rules and methods, the operators have to apply in order to fulfill the security objectives of CEA. CEA has to provide the regulatory authority with documents proving that it is in accordance with the requirements of the 25th July 1980 law and 12th May 1981 decree. It has to implement all the necessary means in order to achieve the results requested by the regulatory authority. All these arrangements are described in the 'license and control file'. This file should specify the facility safeguards and physical protection system. Accounting measures are also described. In this file, the petitioner has to justify its capacity for holding nuclear materials and for exercising authorized activities on them. So the organization and the installed means have to be described in this authorization file. For physical protection, containment, surveillance and physical protection measures are presented: Containment measures must prevent the unauthorized or unjustified movements of nuclear material in the framework of the authorized activities; Surveillance measures must guarantee the integrity of the containment, check that no material is exiting by an abnormal channel; Physical protection measures for the materials, the premises and the facilities are intended to protect them against malevolent actions by means of security systems. The Central Security Division has established guidelines to provide guidance to the nuclear materials holders in writing such files. Each holding unit has to establish a 'license and control file' and each CEA site establishes a 'site license and control file'. Guidelines have been

  16. Annual report of the Association EURATOM/Cea

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, Ph.; Le Vagueres, F

    2002-07-01

    This annual report presents research activities, which have been performed in 2002 by the French EURATOM-Cea association in the frame of the European technology program. The first section describes EFDA (European fusion development agreement) activities and related developments carried out by the association. The second one is dedicated to the underlying technology program and finally the third one presents the inertial confinement fusion activities. In each section the tasks are sorted out according to the EFDA main fields: physics (heating and current drive, remote participation, diagnostics), vessel/in-vessel (vessel/blanket, plasma facing components, remote handling), magnet, tritium breeding and materials (water cooled lithium lead blanket, helium cooled pebble bed blanket, helium cooled lithium lead blanket, reduced activation ferritic martensitic steels, advanced materials, neutron source, fuel cycle), safety and environment, system studies (power plant conceptual studies, socio-economic studies) and JET technology activities. The EURATOM-Cea association is involved in all these studies.

  17. 50. anniversary of the CEA. Anniversary Symposium papers

    International Nuclear Information System (INIS)

    This conference is composed of three tomes, and the titles of the various sessions are: fifty years of nuclear history; nuclear connection balance; uranium enrichment; nuclear wastes: past and present; nuclear fuel reprocessing; nuclear safety; research reactors at the CEA; birth of a scientific discipline, neutronics; fusion through magnetic confinement; large machines for the infinitesimal; laser, a marvelous tool; exploration of condensed matter; knowledge of the atomic nucleus; invariances and symmetries; nuclear astrophysics; polymers and interfaces; micro-electronics and micro-technologies; prospective with nano-technologies; metallurgy and materials; modelization and numerical simulation; electromagnetism and stealth; CEA, chemistry, health and environment; climate and environment, our past and future; the Earth from its formation to Man; life and nuclear tools; photosynthesis, how living beings use solar energy

  18. Application of VLLW management principles to the CEA research centers

    International Nuclear Information System (INIS)

    This document describes the content of a CEA policy relating to very low level waste management elaborated in application of the waste management principles defined in France. The policy deals with very low level waste, subject to recycling, incineration or landfill disposal. It does not deal with reuse. The following principles are applicable to waste streams produced by CEA nuclear installations either during operating or dismantling activities. The policy deals only with very low level wastes (VLLW) (order of magnitude: <100 Bq/g for high energy emitters). It does not deal with low, intermediate or high level waste, which are either recycled or incinerated in nuclear industry or disposed of in the Aube surface disposal (CSA) or kept in intermediate storage, before geological disposal or any alternative final solution

  19. The CEA and alternative energies. 8 April 2010 press conference

    International Nuclear Information System (INIS)

    This document presents the CEA's strategy in terms of alternative energies and the various implemented research programs which mainly concern the building sector and the transport sector. After a recall of the energy and climate context, a presentation of the NTE program (Nouvelles Technologies de l'Energie, new energy technologies), the different topics and projects are presented: photovoltaic solar energy and its integration in building; batteries, hydrogen and fuel cells for applications in transports; second-generation bio-fuels

  20. Facilities offered by the CEA group for training foreign specialists

    International Nuclear Information System (INIS)

    First set up in 1945, the CEA (French Atomic Energy Commission) opened its doors to foreign scientists and technicians as long ago as the 1950s, and particularly so since 1960. Among the 15 000 foreigners concerned, some have come in the capacity of co-workers, while others - approximately 10 000 - have taken courses for the purpose of receiving training. Since the CEA constitutes both a public scientific institution and an industrial group, especially by virtue of its branch organizations and specialized production units, it possesses incomparably varied facilities. This is why almost all the countries of the world, at some time or other, have had nationals at the Saclay, Fontenay-aux-Roses, Grenoble and Cadarache research centres, or the National Institute of Nuclear Science and Technology (INSTN) at Saclay, a specialized establishment set up in 1956, or else at the Razes Information and Further Training Centre (CIPRA), specializing in the uranium ore industry. Most of the trainees received over the last few years by the CEA Group stem from the developing countries, those coming to receive practical technological training being ever more numerous. Several of the training programmes devised have involved participation in industrial operations, either in conjunction with Technicatome, a branch organization specializing in nuclear engineering (Iran, Iraq) or in association with other CEA Group units (South Korea). The trainees usually receive fellowships through the intermediary of French diplomatic missions, in which case it is enough if they continue to receive the salary normally paid to them by the public organization employing them. On the other hand, technological training sometimes involves payment because of the expense involved (intensive supervision and expensive experimental work). Finally, courses in French are organized in France by specialized institutions, but English is acceptable for very brief training periods. (author)

  1. RELAP4/MOD-5-CEA pump coastdown experiment simulation

    International Nuclear Information System (INIS)

    Since is important the theoretical-experimental comparison to evaluate the computer codes, these paper presents the simulation with RELAP4/MOD5 Code of a loss of power energy in the pump of the ''Circuito Experimental de Agua-CEA''. From the results attained, the existing models in the Code showed to be very satisfatory quantitative and qualitative behavior of the attained experimental results. (author)

  2. Report transparency and nuclear safety 2007 CEA Marcoule

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Marcoule for the year 2007. Since its creation in 1955 the center realizes industrial and scientific activities relative to the civil and military applications of the radioactivity. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the following two base activities are detailed: Atalante and Phenix. (A.L.B.)

  3. Fire fight and security in CEA's research centers

    International Nuclear Information System (INIS)

    In each CEA's center a special unit called FLS (formation locale de securite) is in charge of the protection of staff and property. This unit is polyvalent and qualified for fire fight, first aid and guarding, its members are recruited mainly among the Paris fire brigade and the Marseilles' brigade of sea firemen. Their role is to prevent and detect any risk whatever this risk may be: chemical, electric or nuclear. (A.C.)

  4. Report transparency and nuclear safety 2007 CEA Saclay

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Saclay for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially two public consultation on release authorizations and the Neurospin installations, the dismantling of the 49 nuclear installation, the shutdown of the learning reactor ULYSSE are detailed. (A.L.B.)

  5. CEA's research programmes on future nuclear power systems

    International Nuclear Information System (INIS)

    The CEA (Commissariat a l'energie atomique et aux energies alternatives) is at the crossroads between sciences and technologies. In collaboration with corporate leaders and academics, it is working to improve the competitiveness of the existing fleet of nuclear facilities (PWR reactors and EPR) and to develop both a fourth generation of nuclear power reactors and technologies for processing spent fuel. Concerning the PWR reactors most of the work focuses on the extension of reactor operating life (till 60 years), a better use of uranium fuel in the reactor core, a better safety standard, a better reliability of fuel assemblies. This work is both theoretical and experimental with the possibility to use irradiation rigs at the OSIRIS reactor. Concerning the EPR most of the work is dedicated to sustain the commissioning and start of the first EPR in France on the Flamanville site. Concerning the fuel cycle, CEA's teams are working to improve every stage of the cycle from uranium extraction to the processing of spent fuels. In the nuclear industry, industrial cycles are very long so it is today's work to prepare the fourth generation of reactors even if the first reactor of the third generation is not yet in operation. CEA's research focuses on 2 types of fast reactors, one is sodium-cooled (with ASTRID prototype) while the other is gas-cooled (with ALLEGRO prototype). (A.C.)

  6. Lessons learned from CEA experience with dismantling project

    International Nuclear Information System (INIS)

    Since the late 1980s the CEA has been actively implementing methods to benefit from its experience in dismantling nuclear facilities. Capitalizing on prior experience - originally to address safety requirements - has now acquired greater importance in the CEA with the implementation of project management knowledge bases that require better control of performance and cost from initial estimates to completion. Changing regulations (waste, radiological protection, safety, etc.) and decommissioning policies in major organizations (objectives, funding, deadlines, organization, etc.) significantly influence dismantling projects. Experience with knowledge management has shown that the approach consisting in exhaustive project data collection often produces large, unwieldy information bases that are difficult to apply to subsequent projects. Principles and recommendations can nevertheless be derived, but require detailed analysis of all the aspects of dismantling (waste, dosimetry, conventional and nuclear safety, cost, deadlines, physical and radiological environment, regulatory provisions, etc.). The wide range of CEA facilities, the different stages in the course of a project that often lasts for several decades, changing operators and supervisors, all imply that a given situation can be assessed and reconsidered differently depending on the project organization, participants and background. Past results can be considered technically satisfactory, but poorly rated in terms of cost or scheduling. The current approach consists in focusing more on the relevance of the information conserved, favoring common practices emanating from a dedicated center of expertise, and applying suitable processes after discriminating between the lessons learned directly from experience and from consolidation of professional knowledge bases. (author)

  7. Overview on CEA Contributions to the Broader Approach Projects

    International Nuclear Information System (INIS)

    Full text: France is participating to the joint Europe-Japan so-called “Broader Approach Activities” in support of ITER and DEMO activities, consisting in 3 projects: The Engineering Design and Validation of a 14 MeV neutrons irradiation facility (IFMIF/EVEDA), the building of an International Fusion Research Center (IFERC) and the ITER Satellite Tokamak Programme (STP - JT-60SA). For IFMIF/EVEDA activities, CEA is in charge of the high intensity Injector, the first part of the Superconducting RF Linac, the Cryoplant, the Accelerator Control System, the delivery of specific Beam Diagnostics and RF power tubes. This activity covers the fabrication of the systems, test of most critical components, installation and commissioning at the Japanese site. For IFERC, in 2011, CEA contracted with Bull the procurement of the “Helios” computer which reached a performance of 1.5 Petaflop/s peak, making it, with its 70000 compute cores, the largest supercomputer dedicated to a single scientific community. It is complemented by large high bandwidth storage, pre/post processing, visualization systems and services for 5 years. The work started in Sept. 2007. In Jan. 2012, first users started to work. Helios was inaugurated in March 2012. For JT-60SA tokamak, CEA is responsible for providing the Cryoplant System (CS), 9 of the 18 Toroidal Field Coils and supporting structures, the TF Coils Test Facility (CTF) and cold tests, and 5 Magnet Power Supplies (MPS). CEA is also participating to the JT-60SA Research Plan update. TF coil activities started in 2007; a manufacturing contract was placed to Alstom in July 2011. The last coil will be delivered to Japan in late 2016. Prior shipment, coils will be tested in the CTF at CEA-Saclay. The CS was optimized to smooth the transient heat loads during plasma operation. For CS and MPS contract are expected to be placed in June and Dec. 2012 respectively. This paper gives an overview of present status of these projects since 2007

  8. Radioimmunoscintigraphy of non-small cell lung cancer using Tc-99m ANTI-CEA FAB` (immuRAID CEA)

    Energy Technology Data Exchange (ETDEWEB)

    Fig, L.M. [DVA Medical Center, Ann Arbor, MI (United States); Hughes, L.; Pinsky, C.M. [Immunomedics Inc., Morris Plains, NJ (United States)] [and others

    1994-05-01

    We conducted a Phase II prospective multicenter clinical trial to investigate the safety and efficacy of Tc-99M anti-CEA Fab`(ImmuRAID-CEA) in patients with non-small cell lung cancer. Fifty four patients (42 male; 12 female; age range 40-93 yr) had primary operable (19), primary inoperable (7), occult (9), metastatic (15) or recurrent (4) disease. Patients were injected with 1 mg ImmuRAID-CEA radiolabeled with 20-30 mCi Tc-99m pertechnetate and imaged at 4-8 and 18-24 hr by planar and SPECT techniques; ten were imaged at 15-18 hr only. Despite prominent blood pool activity at 4-8 hr. overall imaging statistics on a per patient basis revealed a sensitivity of tumor detection of 90%, accuracy 85% and positive predictive value 94%. The later images had lower count rates but target to background ratios were improved. On a per lesion basis, sensitivity in the chest was 69% and in liver 88%. Twenty four patients had additional foci of antibody uptake at sites previously believed to be uninvolved; cancer was confirmed in 11, not confirmed in 2 and currently indeterminate in 11. Furthermore, a negative scan confirmed equivocal radiographic studies as true negative in 5 patients. With respect to safety, there were no adverse clinical reactions and four minor, transient changes in hematologic and/or biochemical parameters. Human anti-mouse antibody (HAMA) determinations on 27 patients using ImmuSTRIP{reg_sign} HAMA Fragment assay were negative at 4-6 weeks or 3 months post-infusion. We conclude that imaging with ImmuRAID-CEA is safe and potentially useful for the evaluation and staging of lung cancer patients.

  9. Communication dated 8 April 2014 received from the Permanent Mission of the Netherlands to the Agency regarding The Hague Nuclear Security Summit Communiqué

    International Nuclear Information System (INIS)

    The Director General has received a communication dated 8 April 2014 from the Permanent Mission of the Netherlands to the Agency, enclosing the Communiqué of the Nuclear Security Summit 2014, which took place on 24-25 March 2014 in The Hague. The communication and, as requested by the Permanent Mission, the Communiqué are circulated herewith for information

  10. Development in road safety research. Closing lecture at the International Seminar "Recent developments in road safety research", The Hague, 20 November 1986.

    NARCIS (Netherlands)

    Asmussen, E.

    1986-01-01

    On November 20, 1986 an international seminar on "Recent developments in road safety research" was held in The Hague on the occasion of the departure of Prof. Asmussen as director of the Dutch Institute for Road Safety Research SWOV (see IRRD 800967). In this report the closing lecture is presented.

  11. METABOLISMO ÁCIDO DE LAS CRASULÁCEAS Crassulacean Acid Metabolism

    Directory of Open Access Journals (Sweden)

    THOMAS DAVID GEYDAN

    Full Text Available Se presenta una revisión del metabolismo ácido de las Crasuláceas, caracterizado por la ocurrencia, actividad y plasticidad del mecanismo desde un punto de vista fisiológico, bioquímico y molecular, enmarcado por la presencia de las denominadas cuatro fases de dicho metabolismo y su repercusión y expresión por diversas restricciones hídricas a nivel ecológico. Se presentan las principales enzimas y metabolitos básicos para el funcionamiento del metabolismo CAM, así como su modo de acción y control celular. Finalmente, se muestra que la plasticidad fenotípica en patrones de expresión CAM se encuentra mediada por condiciones ambientales y por señalizaciones moleculares.A review of Crassulacean acid metabolism is presented, characterized by showing the occurrence, activity and plasticity of these complex mechanism at the physiological, biochemical and molecular level, framed by the presence of the denominated four phases in CAM and its repercussion and expression due to different stresses in an ecological context. The basic enzymes, and metabolites necessary for the optional functioning of CAM are presented as well as their mode of action and cellular control. Finally, it is shown how environmental conditions and molecular signalling mediate the phenotypic plasticity.

  12. Analysis of the relationship between relative abundance of mature, impregnated females of Pleoticus muelleri (Bate, 1888 (Crustacea, Decapoda and environmental variables through statistical models Análisis de la relación entre la abundancia relativa de las hembras maduras e impregnadas de Pleoticus muelleri (Bate, 1888 (Crustácea, Decapoda y las variables ambientales aplicando modelos estadísticos

    Directory of Open Access Journals (Sweden)

    Mónica Fernández

    2011-01-01

    Full Text Available The relationship between the relative abundance of mature and impregnated females of the Argentine red shrimp Pleoticus muelleri (Bate 1888 and environmental variables was analyzed using statistical methods. Analyzed data carne from the research cruises of the Instituto Nacional de Investigación y Desarrollo Pesquero (INIDEP carned out durmg January 2000, 2001, 2005, and 2007; March 2006; and November 2004, 2005, and 2006 in San Jorge Gulf (Argentina. The biological variables considered were the relative abundances of mature and impregnated female shrimp, whereas the environmental variables corresponded to depth, bottom water temperature and salinity, and the difference between surface and bottom water temperature and salinity. Generalized additive models were used as an exploratory tool for the numerical data and the general linear models as a confirmatory tool. The results showed that the distributions and abundances of mature and impregnated females were related to the bottom water temperature and salinity and to depth. The relationship increased along with temperature; with salinity, however, it decreased for mature females and increased for impregnated females. An optimal depth range was evidenced, where the largest concentrations of these individuáis were located.Se presenta el análisis de la relación entre la abundancia relativa de las hembras maduras e impregnadas del langostino Pleoticus muelleri (Bate, 1888 y las variables ambientales, mediante la aplicación de modelos estadísticos. Los datos analizados provienen de las campañas de investigación del Instituto Nacional de Investigación y Desarrollo Pesquero (INIDEP realizadas en enero de 2000, 2001, 2005 y 2007, marzo de 2006 y noviembre de 2004, 2005 y 2006 en el Golfo San Jorge (Argentina. Se consideraron las variables biológicas: abundancia relativa de hembras maduras y de hembras impregnadas de langostino y las variables ambientales: profundidad, temperatura y salinidad

  13. Notas sobre escrofulariáceas de Colombia, II. "Stemodia mutisii" Fernández Alonso, sp. nov., y otras congéneres, en la flora de la Real Expedición Botánica del Nuevo Reino de Granada (1783-1816)

    OpenAIRE

    Fernández Alonso, José Luis

    1987-01-01

    Se describe una nueva especie del género Stemodia (Scrophulariaceae), basada en material colombiano y en las ilustraciones inéditas de la Expedición Botánica del Nuevo Reino de Granada. Se analizan algunas notas escritas durante dicha Expedición relativas a plantas de este género.

  14. Producing energy without greenhouse effect gases: the CEA action

    International Nuclear Information System (INIS)

    Major actor in the domain of new energy technologies, the CEA manages the french research on the hydrogen and the fuel cells. It is also implied with INES (National Institute for the Solar Energy) in the photovoltaic and thermal solar. With the IFP (French Petroleum Institute), it manages research on biofuels. Of course the thermonuclear fusion, for the development of the energy of the future, is in its research program too. This information document presents the possibilities of these energies and the associated research programs. (A.L.B.)

  15. Technical Aspect of Shielded SIMS Installation in CEA Cadarache

    International Nuclear Information System (INIS)

    A shielded IMS 6f has been installed in the LECA facility, CEA Cadarache France. The nuclearization was performed by CAMECA Company, which sells the standard IMS 6f. Working on nuclear materials requires in depth modifications of the apparatus itself. Despite these modifications, the shielded SIMS has the same level of performance as the standard apparatus. The design of the modified apparatus is presented and the safety aspects are emphasised. The shielded SIMS should be allowed to handle irradiated samples at the end of 2001. (Author)

  16. The 1988 CEA progress report on laser research programs

    International Nuclear Information System (INIS)

    The 1988 CEA progress report, concerning laser investigations, is presented. The aim of the research programs on laser/matter interactions is to contribute to the military application works on this field, as well as to the development of the inertial confinement fusion physics. The activities related to the installation and starting of Phebus laser system are described. The development of soft x-ray instrumentation are included. In the field of numerical simulations, the improvement of FCI 1 and 2 codes are extended for increasing the field of the physical phenomena taken into account and getting their use more flexible to the experiment analysis

  17. Datura Genus Weeds as an Epidemiological Factor of Alfalfa mosaic virus (AMV, Cucumber mosaic virus (CMV, and Potato virus Y (PVY on Solanaceus Crops Malezas del Género Datura como Factor Epidemiológico del Virus del mosaico de la alfalfa (AMV, Virus del mosaico del pepino (CMV y Virus Y de la papa (PVY en Solanáceas Cultivadas

    Directory of Open Access Journals (Sweden)

    Juan Ormeño

    2006-12-01

    Full Text Available Plant samples of jimsonweed (Datura stramonium L. and thornapple (D. ferox L. were collected to determine the presence of Cucumber mosaic virus (CMV, Alfalfa mosaic virus (AMV, and Potato virus Y (PVY in Santiago, Chile (33º34’ S lat, 70º38’ W long, altitude 625 mosl, using double stranded RNA (dsRNA analysis and ELISA. Both weeds were positive to the three types of virus with a percentage of infection ranging from 20-30% except for PVY infection in D. stramonium with an incidence of 5%. Under controlled conditions, the aphid Myzus persicae (Sulzer transmitted CMV from D. ferox to tomatoes (Lycopersicon esculentum Mill. and sweet peppers (Capsicum annuum L., but did not transfer it to potatoes (Solanum tuberosum L.. Seeds of positive D. stramonium and D. ferox plants did not transmit CMV, AMV or PVY. In the field, the presence of virus-infected Datura plants in the vicinity of the test crop plots and flight activity of aphid vectors was not correlated with the levels of infection of tomatoes, peppers and potatoes. Wind direction probably affected the ability of flying vectors to transmit viruses. Datura weeds, especially D. ferox, ought to be controlled not only because of economic losses produced by weed-crop competition, but also because they are alternative hosts of CMV, AMV and PVY. >From an epidemiological perspective, management of weed control ought to include not only D. ferox plants within the crop, but also plants surrounding the upwind edges of the field.En Santiago, Chile (33º34’ lat. Sur, 70º38’ long. Oeste, altitud 625 m.s.n.m. se colectaron plantas de chamico (Datura stramonium y D. ferox para determinar la presencia del Virus mosaico de la alfalfa (AMV, Virus mosaico del pepino (CMV y Virus Y de la papa (PVY mediante análisis doble stranded RNA (dsRNA y ELISA. Ambas malezas fueron positivas a los tres tipos de virus y los porcentajes de infección estuvieron entre 20-30%, excepto para PVY en D. stramonium que fue de

  18. Hookah smoking and cancer: carcinoembryonic antigen (CEA) levels in exclusive/ever hookah smokers

    OpenAIRE

    Chaouachi Kamal; Sajid Khan; Mahmood Rubaida

    2008-01-01

    Abstract Background We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere) and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (cigarettes, bidis, etc.). Objectives To find serum CEA levels in ever/exclusive hookah smokers, i.e. those who smoked only hookah (no cigarettes, bidis, etc.), prepared b...

  19. Evaluation of the nuclear installations safety of the CEA in 1998

    International Nuclear Information System (INIS)

    Michel Laverie, Director of the nuclear safety and quality at the Cea, took stoke of the CEA nuclear installations in 1998. After a recall of the nuclear safety policy and organization, the author presents the risks factors bound to the CEA activities as the dismantling, the wastes and the human factors. A last part is devoted to the list of the accidents occurred during 1998 in the nuclear installations. Tables and statistics illustrate this analysis. (A.L.B.)

  20. Preoperative serum levels of CEA and CA 242 in colorectal cancer.

    OpenAIRE

    Carpelan-Holmström, M; Haglund, C.; Kuusela, P.; Järvinen, H; Roberts, P. J.

    1995-01-01

    Preoperative serum levels of CEA and CA 242 were determined in 260 patients with colorectal cancer and in 92 patients with benign colorectal diseases. The overall sensitivity of the CEA test was 43% and of the CA 242 test 39%. The corresponding specificities were 90% and 87% respectively, using 5 ng ml-1 as cut-off level for CEA and 20 U ml-1 for CA 242. The sensitivity of CEA was 26%, 32%, 38% and 77% for Dukes A, B, C and D colorectal cancer, and the sensitivity of CA 242 was 26%, 26%, 40% ...

  1. Transportation of vitrified residues towards Switzerland; Le transport des residus vitrifies vers la Suisse

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This document presents the swiss policy concerning the spent fuel management and the participation of COGEMA to the spent fuel processing. In this framework the swiss spent fuel processing at COGEMA La Hague, the transports safety and management, the regulatory framework applied to the transports, the quality and safety control and the ultimate residues storage are presented. (A.L.B.)

  2. Radioiodination of monoclonal antibody intact anti-CEA

    International Nuclear Information System (INIS)

    The purpose of this study is to examine a convenient system that can be used to iodinate monoclonal antibodies which is rapid, simple, efficient and reproducible, and which can be accomplished in radiopharmaceutical laboratories. It is important to remember that antibodies are sensitive biochemicals, subject to losses of the activity that is essential to their mode of action, namely the ability to bind specific antigen. The advent of solid phase iodination agents has greatly expanded the range of gentle iodination techniques available for iodinating sensitive biological materials. The agent most widely used is the Iodogen (1,3,4,6 tetrachloro-3a-6a diphenylglycoluril) method. Anti-CEA 4C sub(11) IgG sub(2a,k) (prepared in the Ludwig Institute-Sao Paulo-Brazil ) is used as model to evaluate the Iodogen methodology. The miniature chromatographic system, also rapid, accurate, simple, efficient was elaborated to determine the labelling efficiency incorporation of iodine into immunoglobulin, and the radiochemical purity of sup(131)I-anti-CEA. (author)

  3. CEA technical-economic activity report - Year 2014

    International Nuclear Information System (INIS)

    This report presents an assessment of activities undertaken by the CEA in the field of energy technique and economy during 2014. Technical-economic studies aims at contributing to national orientations on energy, at R and D program orientations, at highlighting and strengthening synergies between nuclear technologies and new energy technologies, and at strengthening the credibility of these technologies. After a presentation of the organisation of technique and economy within the CEA, of the involved bodies and departments, of the addressed themes (photovoltaic, wind, biomass and biofuels, hydrogen-based systems, mobility, electric systems and grids), the report presents studies performed in relationship with the national energy strategy and with energy scenarios, studies performed in the nuclear field (on fourth-generation reactors, on the front-end and back-end of the fuel cycle), studies performed in the field of new energy technologies and climate (hydrogen and storage, biofuels, climate, mobility, solar, electric systems). The next part addresses academic aspects, methodological studies and modelling studies. Contributions and participations to conferences, and publications are indicated

  4. 3rd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Drouin, Antoine; Roos, Clément

    2015-01-01

    The two first CEAS (Council of European Aerospace Societies) Specialist Conferences on Guidance, Navigation and Control (CEAS EuroGNC) were held in Munich, Germany in 2011 and in Delft, The Netherlands in 2013. ONERA The French Aerospace Lab, ISAE (Institut Supérieur de l’Aéronautique et de l’Espace) and ENAC (Ecole Nationale de l’Aviation Civile) accepted the challenge of jointly organizing the 3rd edition. The conference aims at promoting new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems. It represents a unique forum for communication and information exchange between specialists in the fields of GNC systems design and operation, including air traffic management. This book contains the forty best papers and gives an interesting snapshot of the latest advances over the following topics: l  Control theory, analysis, and design l  Novel navigation, estimation, and tracking methods l  Aircr...

  5. CEA contribution to power plant operation with high burnup level

    International Nuclear Information System (INIS)

    High level burnup in PWR leads to investigate again the choices carried out in the field of fuel management. French CEA has studied the economic importance of reshuffling technique, cycle length, discharge burnup, and non-operation period between two cycles. Power plants operators wish to work with increased length cycles of 18 months instead of 12. That leads to control problems because the core reactivity cannot be controlled with the only soluble boron: moderator temperature coefficient must be negative. With such cycles, it is necessary to use burnable poisons and for economic reasons with a low penalty in end of cycle. CEA has studied the use of Gd2O3 mixed with fuel or with inert element like Al2O3. Parametric studies of specific weights, efficacities relatively to the fuel burnup and the fuel enrichment have been carried out. Particular studies of 1 month cycles with Gd2O3 have shown the possibility to control power distribution with a very low reactivity penalty in EOC. In the same time, in the 100 MW PWR-CAP, control reactivity has been made with large use of gadolinia in parallel with soluble boron for the two first cycles

  6. Scientific evaluation at the French Atomic Energy Commission (CEA). 2005-2006 annual report; L'evaluation scientifique au CEA. Rapport annuel 2005-2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This report aims at presenting the scientific evaluation activities carried out at the CEA during the years 2005-2006. The evaluation system is described in detail. It comprises two aspects: the evaluation of the scientific policy implemented by the scientific Council and by the visiting committee of the CEA, and the evaluation of the laboratories, performed by a pool of 36 scientific councils. The evaluation by external and independent parties is the key point of this system. This document makes a status of the evaluations performed in 2005 and 2006. It presents a synthesis of the conclusions of the evaluation authorities. The actions implemented by the CEA to take into consideration the recommendations are also reported with the improvements noticed. The two topics examined by the scientific Committee and by the visiting committee were dealing with the energy domain, which is a strategic issue for the CEA. The examination of the researches on future nuclear reactors and on new energy technologies have shown the major role played by the CEA in the recent advances in these domains. About 95% of the laboratories activity was examined during the 2002-2005 period. The richness of the remarks and recommendations made by the scientific councils should allow the CEA to improve the quality and relevance of its research works. The start-up of the 2006-2009 evaluation cycle has been the occasion to modify the evaluation of some research domains in order to take into account the evolution of programs. The evaluation system of the CEA is highly consistent with the AERES principles. Its implementation, adapted to each type of activity (fundamental research, applied research, technological developments) allows the CEA to follow up a permanent improvement approach. (J.S.)

  7. Sensitivity and specificity of the GAMMACOAT-M CEA-RIA from Travenol-Genentech Diagnostics compared to the ABBOTT CEA-RIA monoclonal

    International Nuclear Information System (INIS)

    A new monoclonal radioimmunoassay from Travenol-Genentech Diagnostics was investigated with respect to its sensitivity and specificity and compared to the established monoclonal antibody assay of ABBOTT. Both tests revealed increased CEA plasma values in healthy smokers, whereby the elevation was dependent on the number of cigarettes smoked per day. The sensitivities as well as the cut-off levels for CEA at 90% specificity were coincident in both tests. (orig.)

  8. Application of monoclonal antibodies to purified CEA in clinical radioimmunoassay of human serum

    International Nuclear Information System (INIS)

    Double-antibody radioimmunoassay using a mouse monoclonal anti- CEA (MA/1) has been used to measure CEA in human serum. Low levels of MA/1-binding CEA have been found in serum from normal individuals and moderately raised levels are sometimes associated with certain non-malignant diseases. As with conventional anti-CEA, the MA/1 antibodies can recognize significant amounts of CEA in serum from patients with a variety of solid tumours. However they appear to recognize a different immunodeterminant and possibly a different population of CEA molecules to, or a subset of, those measured by two routine assays. Studies in which the MA/1 assay was directly compared with the results of the Charing Cross routine and Abbott EIA assays have indicated that different immunological forms of CEA may be expressed in the course of tumour progression but no prognostic value was evident in this study. The results stress the need to resolve immunological specificities expressed by CEA-like molecules and evaluate their clinical importance. (author)

  9. Assessment 2000 and regulation and method. Releases control and environmental survey of the CEA Centers

    International Nuclear Information System (INIS)

    The environment quality around the CEA centers is a major interest of its safety policy. These documents contribute to the public information on the radioactive liquid and gaseous releases of the CEA, according to the ministry authorization. The radioactivity monitoring activity, and the survey methods are also presented. Data analysis from 1996 to 2000, allows to follow the evolution. (A.L.B.)

  10. Vegetación espontánea preferida por hormigas cortadoras en plantaciones de Salicáceas en el Delta del Paraná

    OpenAIRE

    Perri, Daiana; Casaubón, Edgardo; Gorosito, Norma; Gurini, Laura Beatriz; Fernández, Patricia Carina

    2015-01-01

    La vegetación de crecimiento espontáneo, llamada “maleza” es considerada perjudicial para las plantaciones de sauce y álamo. Las hormigas cortadoras de hojas (Acromyrmex sp.) son una de las plagas más importantes en la producción de Salicáceas y son combatidas con insecticidas de síntesis que contaminan el ambiente. El objetivo de este trabajo fue comenzar a evaluar las plantas cortadas por las hormigas en el campo y realizar ensayos de preferencia con el fin de proponer especies como cultivo...

  11. General rules for radiation protection within the CEA

    International Nuclear Information System (INIS)

    This report first describes the organisation, scope of application and principles of radiation protection within the CEA. The second part proposes an overview of rules applicable to workers exposed to ionizing radiation. These rules concern the personnel classification, exposure limits, individual control, and training of workers in radiation protection. The third part addresses the technical rules for premise laying-out: protection zoning, indicators aimed at controlling the compliance of premise classification, radiological survey and control of premise classification. The fourth part addresses the modalities of access, stay and operation in regulated zone. The next part indicates and comments arrangements specific to ionizing radiation sources and to ionizing radiation emitting equipment (authorization and possession modalities, training, certification, controls, operation zoning, etc.), specific orders (radiological control of wastes, hardware, tools and equipment management), rules related to abnormal occupational situations (alarms, contamination event, radiological events), and the different studies and analysis of radiation protection implemented during the different phases of an installation lifetime

  12. Report on transparency and nuclear safety 2014 - Cadarache CEA centre

    International Nuclear Information System (INIS)

    This document proposes, first, a presentation of the Cadarache CEA centre, of its activities and installations, gives a rather detailed overview of measures related to safety and to radiation protection within these activities and installations. Then it reports significant events related to safety and to radiation protection which occurred in 2014 and have been declared to the ASN. Next, it discusses the results of release measurements (liquid and gaseous effluents, radiological assessment, and chemical assessment for various installations) and the control of the chemical and radiological impact of these gaseous and liquid effluents on the environment. Finally, it addresses the issue of radioactive wastes which are stored in the different nuclear base installations of the Centre, indicates the different measures aimed at limiting the volume of these warehoused wastes and addresses their impact on health and on the environment. Nature and quantities of warehoused wastes are specified. Remarks and recommendations of the CHSCT are given

  13. Cryogenic turbulence test facilities at CEA/SBT

    Science.gov (United States)

    Rousset, B.; Baudet, C.; Bon Mardion, M.; Bourgoin, M.; Braslau, A.; Daviaud, F.; Diribarne, P.; Dubrulle, B.; Gagne, Y.; Gallet, B.; Gibert, M.; Girard, A.; Lehner, T.; Moukharski, I.; Sy, F.

    2015-12-01

    Recently, CEA Grenoble SBT has designed, built and tested three liquid helium facilities dedicated to turbulence studies. All these experiments can operate either in HeI or HeII within the same campaign. The three facilities utilize moving parts inside liquid helium. The SHREK experiment is a von Kármán swirling flow between 0.72 m diameter counterrotating disks equipped with blades. The HeJet facility is used to produce a liquid helium free jet inside a 0.200 m I.D., 0.47 m length stainless steel cylindrical testing chamber. The OGRES experiment consists of an optical cryostat equipped with a particle injection device and an oscillating grid. We detail specific techniques employed to accommodate these stringent specifications. Solutions for operating these facilities without bubbles nor boiling/cavitation are described. Control parameters as well as Reynolds number and temperature ranges are given.

  14. The stationary storage of energy. Available technologies and CEA researches

    International Nuclear Information System (INIS)

    After a discussion of the main challenges related to the stationary storage of energy, this publication proposes an overview of the different available technologies: plant for transfer of energy by pumping, compressed air, energy flywheels, hydrogen, lithium-ion battery, redox-flow battery, thermal storage by sensitive heat, thermal-chemical storage coupled to a thermal solar system, thermal storage by phase change, superconductive inductance storage, super-capacitors. It discusses the criteria of choice of storage technology, either for electric energy storage or for heat storage. It proposes an overview of researches performed within the CEA on storage systems: electrochemical, thermal, and hydrogen-based storages. The final chapter addresses current fundamental researches on storage in the field of lithium-ion batteries, hydrogen as a fuel, and thermoelectricity

  15. Recent advances in indirect drive ICF target physics at CEA

    International Nuclear Information System (INIS)

    The objective of Target Physics Program at CEA is the achievement of ignition on the LMJ, a glass laser facility of 1.8 MJ which will be completed by 2008. It is composed of theoretical work, experimental work and numerical simulations. An important part of experimental studies is made in collaboration with U.S. DOE Laboratories: Lawrence Livermore National Laboratory, Los Alamos National Laboratory and the Laboratory for Laser Energetics at the University of Rochester. Experiments were performed on Phebus, NOVA (LLNL) and OMEGA (LLE) ; they included diagnostics developments. Recent efforts have been focused on Laser Plasma Interaction, hohlraum energetics, symmetry, ablator physics and hydrodynamic instabilities. Ongoing work prepare the first experiments on the LIL which is a prototype facility of the LMJ (8 of its 240 beams). They will be performed by 2002. Recent progress in ICF target physics allows us to precise laser specifications to achieve ignition with reasonable margin. (author)

  16. Progress in fusion reactors blanket analysis and evaluation at CEA

    International Nuclear Information System (INIS)

    In the frame of the recent CEA studies aiming at the development, evaluation and comparison of solid breeder blanket concepts in view of their adaptation to NET, and the evaluation of specific questions related to the first wall design, the present paper examines first the performances of a helium cooled toroidal blanket design for NET, based on innovative Beryllium/Ceramics breeder rod elements. Neutronic and thermo-mechanical optimisation converges on a concept featured by a breeding capability in excess of 1.2, a reasonnable pumping power of 1 % and a narrow breeder temperature range (470 +- 30 0C of the breeder), the latter being largely independent of the power level. The final section of the paper is devoted to the evaluation of the heat load poloidal distribution and to the irradiation effects on first wall structural materials

  17. CEA contribution to the ITER ICRH antenna design

    International Nuclear Information System (INIS)

    The ITER ion-cyclotron range of frequency (ICRH) heating system is required to couple 20 MW of power in the frequency range 40–55 MHz for a large range of scenarios with Edge Localized Modes. To mitigate the associated risks, it is foreseen to design and install on ITER two port-plug antennas for a total of 20 MW coupled power on long pulse operation [1]. The CEA activity to this antenna design within the CYCLE consortium was focused on the Faraday screen design (Fig. 1) and associated radio frequency (RF) sheath modelling, the reflectometers design for edge density measurement in the antenna vicinity and a contribution to the remote handling/tooling of the antenna. This paper is an overview of each item and proposes some R and D activities on key components

  18. Development of radiolabelling techniques of anti-CEA monoclonal antibody

    International Nuclear Information System (INIS)

    The purpose of this work was to label monoclonal and polyclonal antibodies with 99Tcm such as the ior-CEA-1 antibody and polyclonal IgG using a direct method, to check the radiochemical and biological behavior of labelled products, to prepare it under sterile and apyrogenic conditions as a lyophilized kit and to employ it in clinical trials. In addition, a photoactivation method was used to label polyclonal IgG with 99Tcm and to compare with the established method using mercaptoethanol (2-ME) as the reducing agent. Finally polyclonal IgG was labelled using an indirect method in which a chelator was covalently attached to the protein and the 99Tcm added as glucoheptonate complex. The properties of 99Tcm when labelled with monoclonal and polyclonal antibodies by different methods were assessed by in vitro and in vivo studies

  19. Experimental Feedback on Sodium Loop Decommissioning at the CEA

    International Nuclear Information System (INIS)

    The aim of this paper is to present experimental feedback on sodium loop dismantling techniques at the CEA (The French Atomic Energy Commission) and to offer recommendations for the decommissioning of Fast Breeder Reactor secondary sodium loops. This study is divided into several parts which correspond to the different stages of a dismantling system. It is based on acquired CEA decommissioning experience which primarily concerns the following: the decommissioning of Rapsodie (France's first Fast Breeder Reactor), the Phenix reactor secondary loop replacement, the sodium loop decommissioning carried out by the Laboratory of Sodium Technologies and Treatment, and several technical documents. This paper deals with the main results of this survey. First, a comparison of 8 pipe-cutting techniques is made, taking into account speed in cutting, reliability, dissemination, fire risk due to the presence of sodium, cutting depth, and different types of waste (empty pipes, sodium-filled pipes, tanks...). This comparison has led us to recommend the use of an alternative saw or a chain saw rather than the use of the plasma torch or grinder. Different techniques are recommended depending on if they are on-site, initial cuttings or if they are to be carried out in a specially-designed facility referred to hereafter as 'the cutting building'. After the cutting stage, the sodium waste must be processed with water to become an ultimate stable waste. Four treatment processes are compared with different standards: speed, cost, low activity adaptability and 'large sodium quantity' adaptability. Recommendations are also made for reliable storage, and for the general dismantling system organization. Last, calculations are presented concerning a complete dismantling facility prototype capable of treating large amounts of sodium. (authors)

  20. Estudios sobre el papel del área tegmental ventral y de las regiones dopaminérgicas rostral lineal y periacueductal del mesencéfalo en la adicción y analgesia opiáceas en ratas

    OpenAIRE

    Flores Cordero, Juan Antonio

    2005-01-01

    Falta por incorporar las palabras clave El número medio de cada tipo celular fue de 129,431,3 células grandes de la PAG ventrolateral, 305,843,5 células periacueductales de la PAG y 1441,4210 células pequeñas de la región RLi/PAG ventral. 3. En las neuronas dopamimérgicas grandes de la PAG y pequeñas de la región Rli/PAG ventral (pero no en las periacueductales) se produce una regulación al alza en la expresión de TH tras el tratamiento repetido y subcutáneo con heroína. 4. La infusión del...

  1. A very long engagement: The Children's Act 38 of 2005 and the 1993 Hague Convention on the Protection of Children and Cooperation in Respect of Intercountry Adoption

    OpenAIRE

    M Couzens

    2009-01-01

    This article analyses the intercountry adoptions provisions contained in Chapter 16 of the Children’s Act 38 of 2005, against the standards of the Hague Convention on the Protection of Children and Cooperation in Respect of Intercountry Adoptions, 1993. After a brief overview of the two leading South African cases on intercountry adoption, which stress the importance of having this institution statutorily regulated, the author proceeds to analyse the most significant clauses pertaining to int...

  2. DOE–CEA Benchmark on SFR ASTRID Innovative Core: Neutronic and Safety Transients Simulation

    International Nuclear Information System (INIS)

    ASTRID is a fast reactor being designed by the CEA to achieve a level of safety that exceeds that of conventional fast reactors. In particular, an axially heterogeneous core with an upper sodium plenum is employed to achieve a non-positive sodium void reactivity worth. In order to address the simulation challenges for this innovative concept, the US Department of Energy’s (DOE) Laboratories (Argonne National Laboratory and Idaho National Laboratory) and the CEA are performing neutronic and transient benchmark calculations for an ASTRID model based on design specifications provided by the CEA. The blind comparison of the initial DOE and CEA results are found to be in good agreement, enhancing confidence in CEA predictions of key ASTRID safety relevant parameters and transient behaviour. For several parameters, compared uncertainties in computed values are significant and further studies are needed to reduce them. (author)

  3. Energy audit of three energy-conserving devices in a steel-industry demonstration program. Task I. Hague forge furnaces. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lownie, H.W.; Holden, F.C.

    1982-06-01

    A program to demonstrate to industry the benefits of installing particular types of energy-conserving devices and equipment was carried out. One of these types of equipment and the results obtained under production conditions in commercial plants are described. The equipment under consideration includes improved forge furnaces and associated heat-recovery components. They are used to heat steel to about 2300 F prior to hot forging. The energy-conserving devices include improved insulation, automatic air-fuel ratio control, and a ceramic recuperator that recovers heat from hot combustion gases and delivers preheated air to high-temperature recirculating burners. Twelve Hague furnaces and retrofit packages were purchased and installed by eleven host forge shops that agree to furnish performance data for the purpose of demonstrating the energy and economic savings that can be achieved in comparison with existing equipment. Fuel savings were reported by comparing the specific energy consumption (Btu's per pound of steel heated) for each Hague furnace with that of a comparison furnace. Economic comparisons were made using payback period based on annual after-tax cash flow. Payback periods for the Hague equipment varied from less than two years to five years or more. In several cases, payback times were high only because the units were operated at a small fraction of their available capacity.

  4. Overview of the long-lived radionuclide separation processes developed in connection with the CEA`s spin programme

    Energy Technology Data Exchange (ETDEWEB)

    Madic, C.; Bourges, J.; Dozol, J.F.

    1994-12-31

    One possible strategy for eliminating the long-term potential hazards associated with the storage of vitrified high level waste produced by the processing of irradiated nuclear fuels, is the transmutation of the long-life radionuclides in these wastes into short-life radionuclides by nuclear means, which requires the prior chemical separation of these long-life radionuclides from the nuclear waste mixture. To do this, the French CEA (Atomic Energy Commissionership) launched the SPIN (Separation-Incineration) research programme in 1991, under the law passed by the parliament on december 30, 1991. Research currently under way to develop separation processes for some long-life radionuclides concerns modifications of the Purex process, and the development of new solvent extraction processes. The research directions are briefly summarized here. (authors). 17 refs., 3 tabs.

  5. The Hague Recommendations: Improving Nonlegislative Responses to Trafficking in Human Beings for the Purpose of Organ Removal.

    Science.gov (United States)

    Ambagtsheer, Frederike; Weimar, Willem

    2016-02-01

    Over the years, the trade in human organs has become an object of international concern. Since the 1980s, antiorgan trade initiatives have mainly involved the strengthening of legislative responses. Little attention however is given to nonlegislative responses by law enforcement authorities. The HOTT project is a European Union-funded research project titled "trafficking in human beings for the purpose of organ removal." Its objectives are to increase knowledge, raise awareness, and improve the nonlegislative response to the crime. Its consortium organized a "Writers' Conference" in The Hague, The Netherlands at Europol's Headquarters where a group of 40 experts, consisting of transplant professionals, law enforcement officials, and policy makers, formulated recommendations to improve nonlegislative responses. These recommendations, presented hereafter, address the ethical and legal obligations of health care providers, the protection of persons trafficked for the purpose of organ removal, strengthening cross-border collaboration in criminal cases, and stimulating partnerships between transplant professionals and law enforcement. These recommendations offer ways in which transplant professionals can contribute to improving the nonlegislative response to trafficking in human beings for the purpose of organ removal. PMID:27500254

  6. Selectively assaying CEA based on a creative strategy of gold nanoparticles enhancing silver nanoclusters' fluorescence.

    Science.gov (United States)

    Yang, Xiaoming; Zhuo, Yan; Zhu, Shanshan; Luo, Yawen; Feng, Yuanjiao; Xu, Yan

    2015-02-15

    Herein, we have successfully built up connections between nanoparticles and nanoclusters, and further constructed a surface-enhanced fluorescence (SEF) strategy based on the two types of nanomaterials for selectively assaying carcinoembryonic antigen (CEA). Specifically, silver nanoclusters provided the original fluorescence signal, while gold nanoparticles modified with DNA served as the fluorescence enhancer simultaneously. On the basis of this proposed nano-system, the two nanomaterials were linked by CEA-aptamer, thus facilitating SEF occurring. Nevertheless, more competitive interactions between CEA and CEA-aptamer emerged once CEA added, leading to SEF failed and their fluorescence decreased. Significantly, this creative method was further applied to detect CEA, and showed the linear relationship between the fluorescence intensity and CEA concentrations in the range of 0.01-1 ng mL(-1) with a detection limit of 3 pg mL(-1) at a signal-to-noise ratio of 3, demonstrating its sensitivity and promising towards multiple applications. On the whole, this approach we established may broaden potential ways of combining nanoparticles and nanoclusters for detecting trace targets in bioanalytical fields. PMID:25259877

  7. Methodology for the study of radioactive decontamination products used in Marcoule and La Hague nuclear power plants

    International Nuclear Information System (INIS)

    A study of the toxic properties of radioactive decontamination products is presented using short term biological tests in vitro (AMES test, SOS - Chromotest, tests on alveolar macrophages) and in vivo (micronucleus-test, LD-50) and analytical techniques (coupled gas chromatography - mass spectrometry, atomic absorption spectrometry) allowing a rapid measurement of genotoxic and cytotoxic effects of complex chemical mixtures and the determination of their composition. The study is completed by the assessment of personnel exposure from measured values of biological indicators in urine and by the control of protection measures efficiency. From the results obtained, a methodology is proposed for the detection of toxic risks induced by the occupational use of many industrial chemical products

  8. CHARACTERIZATION OF MONOCLONAL ANTIBODY CL58 AGAINST CARCINOEMBRYONIC ANTIGEN (CEA) AND STUDY OF ITS BIODISTRIBUTION

    Institute of Scientific and Technical Information of China (English)

    李振甫; 杨志; 张宏; 顾晋

    2002-01-01

    Objective: To study the preparation and characterization of monoclonal antibody (McAb) against carcinoembryonic antigen (CEA). Methods: CEA antigen was extracted from metastasized liver of patients with colorectal cancer and used for the preparation of McAb against CEA by hybridoma technique. Immunoreactivity of McAb to CEA antigen was evaluated using ELISA. Mouse ascites was purified by two steps, high performance liquid chromatography (HPLC) using protein A and high performance hydroxylapatite (HPHT). Normal adult tissues and tumor specimen were used for immunohistochemical evaluation of the McAb. Isotope 99mTc labeled CEA McAb was used for biodistribution in tumor-bearing mouse. Results: Purified CEA antigen was a glycoprotein of 180 kD. Anti-CEA McAb affinity constant was 7.4x109/M. The McAb showed positive staining in 54-88% of colorectal cancer, gastric cancer and lung cancer, while negative for normal tissues. 24 hours after injection of 99mTc labeled McAb, tumor ID%/g was higher than 15% and tumor/blood, tumor/kidney and tumor/liver were 1.82, 1.51 and 2.92 respectively. T/NT ratios of other viscera were over 3.0. Conclusion: Purified CEA antigen had very good immunogenicity. The anti-CEA McAb was highly specific. 99mTc labeled McAb was stabled both in vivo and in vitro. In vivo distribution result was satisfactory. McAb CL58 may be useful for RII and RIGS.

  9. Preparation of 99mTc-Anti CEA MAb and biodistribution test in mice

    International Nuclear Information System (INIS)

    99mTc-antiCEA MAb radiopharmaceutical has been commercially used under the brand name of Zevalin which is used to detect colorectal cancer. Although human MAb is preferred but commercial product is still using murine originated MAb. This antibody binds specifically to carcinoembryonic antigen (CEA) which is overexpressed in colorectal cancer cells. AntiCEA MAb was reduced with diluted 2-mercaptoethanol (1:2000) prior to labelling with 99mTc, and MDP was used as transchelating agent. Labeling efficiency was analysed with chromatography using HSA impregnated ITLC-SG as stationary phase and mixture of ammona-ethanol-water (1:2:5) as eluants to determine polar 99mTc impurities, and ITLC-SG eluted with salin to determine 99mTc-colloid. Stability study was carried out on radio labeled antiCEA MAb stored at room temperature within several hours and on reduced antiCEA MAb stored at -40°C for several weeks. Biodistribution of 99mTc-antiCEA MAb in normal mice was observed 1 hour and 4 hours post injection. Labeling efficiency of antiCEA MAb was 98,53% ± 0.21 % and decreasing to less than 90% after 9 weeks. Radiolabeled anti CEA MAb kept at room temperature was stable within 5 hours post injection, and the frozen kits were stable up to 9 weeks. Biodistribution of 99mTc-antiCEA MAb in normal mice at 1 hour and 4 hours post injection showed high uptake in various organs. (author)

  10. Fusion technology. Annual report of the. Association Cea/EURATOM; Technologie de fusion.Rapport annuel de l`association CEA/Euratom

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le Vagueres, F.

    1996-12-31

    In 1996, the French EURATOM-CEA Association made significant contributions to the European technology programme. This work is compiled in this report as follows: the ITER CEA activities and related developments are described in the first section; blankets and material developments for DEMO, long term safety studies are summarised in the second part; the Underlying Technology activities are compiled in the third part of this report. In each section, the tasks are sorted out to respect the European presentation. For an easy reading, appendix 4 gives the list of tasks in alphabetical order with a page reference list. The CEA is in charge of the French Technology programme. Three specific organizational directions of the CEA, located on four sites (see appendix 5) are involves in this programme: Advanced Technologies Direction (DTA), for Material task; Nuclear Reactors Direction (DRN), for Blanket design, Neutronic problems, Safety tasks; Physical Sciences Direction (DSM) uses the competence of the Tore Supra team in the Magnet design and plasma Facing Component field. The CEA programme is completed by collaborations with Technicatome, COMEX-Nucleaire and Ecole Polytechnique. The breakdown of the programme by Directions is presented in figure 1. The allocation of tasks is given in appendix 2 and in appendix 3, the related publications. (author).

  11. Imaging of pharyngeal and laryngeal carcinomas with indium-111-labeled monoclonal anti-CEA antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Kairemo, K.J.; Hopsu, E.V. (Helsinki Univ. Central Hospital (Finland))

    1990-10-01

    Localization of primary tumors, metastases, or recurrences in 13 consecutive patients with histological verification of squamous cell or adenocarcinoma was made with radioimmunodetection using monoclonal radiolabeled anti-CEA antibody. All surgical specimens stained immunohistochemically, except one, were positive for CEA. Of the known 19 tumor sites 17 were visualized in antibody scans. There were two positive findings that did not prove to be positive during 12 month follow-up. The scintigram findings did not correlate with CEA serum concentrations that, with one exception, were normal in all patients.

  12. Imaging of pharyngeal and laryngeal carcinomas with indium-111-labeled monoclonal anti-CEA antibodies

    International Nuclear Information System (INIS)

    Localization of primary tumors, metastases, or recurrences in 13 consecutive patients with histological verification of squamous cell or adenocarcinoma was made with radioimmunodetection using monoclonal radiolabeled anti-CEA antibody. All surgical specimens stained immunohistochemically, except one, were positive for CEA. Of the known 19 tumor sites 17 were visualized in antibody scans. There were two positive findings that did not prove to be positive during 12 month follow-up. The scintigram findings did not correlate with CEA serum concentrations that, with one exception, were normal in all patients

  13. Diferencias en la flora herbácea y arbustiva entre claros y áreas bajo dosel en un bosque de Nothofagus pumilio en Argentina Differences in the herb and shrub flora growing under canopy gaps and under closed canopies in a Nothofagus pumilio forest of Argentina

    OpenAIRE

    M. ANGÉLICA DAMASCOS; EDUARDO H. RAPOPORT

    2002-01-01

    Se comparó la distribución de las hierbas y arbustos bajo el dosel y en dos tamaños de claros del bosque deciduo de Nothofagus pumilio de Argentina. La riqueza total y promedio de especies por cuadrado fueron similares bajo el dosel y en los claros pequeños (diámetro mayor < 5 m) y medianos (diámetro mayor entre 5-10 m). Las especies generalistas fueron las más numerosas (46 %), mientras que el 19 % correspondió a especies heliófobas y el 15 % a heliófilas obligadas y facultativas. La ausenci...

  14. Report on transparency and nuclear safety - Cadarache CEA centre - 2012

    International Nuclear Information System (INIS)

    A first volume proposes a presentation of the Cadarache CEA centre, of its activities and installations, gives a rather detailed overview of measures related to safety and to radiation protection within these activities and installations. It also reports significant events related to safety and to radiation protection which occurred in 2012 and have been declared to the ASN. It discusses the results of release measurements (liquid and gaseous effluents, radiological assessment, and chemical assessment for various installations) and the control of the chemical and radiological impact of these gaseous and liquid effluents on the environment. It addresses the issue of radioactive wastes which are stored in the different nuclear base installations of the Centre, indicates the different measures aimed at limiting the volume of these warehoused wastes and addresses their impact on health and on the environment. Nature and quantities of warehoused wastes are specified. The second volume concerns some specific installations (INB 32 or ATPu, and INB 54 or LPC) which belong to AREVA NC. The same topics are addressed: presentation of the facilities, arrangements regarding safety and radiation protection, significant events related to safety and radiation protection, measurements of effluents and their impact on the environment, warehoused wastes. Remarks and recommendations of the CHSCT are given

  15. Progress in fusion reactors blanket analysis and evaluation at CEA

    International Nuclear Information System (INIS)

    In the frame of the recent CEA studies aiming at the development, evaluation and comparison of solid breeder blanket concepts in view of their adaptation to NET, the evaluation of specific questions related to the first wall design, the present paper examines first the performances of a helium cooled toroidal blanket design for NET, based on innovative Beryllium/Ceramics breeder rod elements. Neutronic and thermo-mechanical optimisation converges on a concept featured by a breeding capability in excess of 1.2, a reasonnable pumping power of 1% and a narrow breeder temperature range (470+-30 deg C of the breeder), the latter being largely independent of the power level. This design proves naturally adapted to ceramic breeder assigned to very strict working conditions, and provides for any change in the thermal and heat transfer characteristics over the blanket lifetime. The final section of the paper is devoted to the evaluation of the heat load poloidal distribution and to the irradiation effects on first wall structural materials

  16. CEA distribution transformer purchasing specifications (DTWG-01,02,03)

    International Nuclear Information System (INIS)

    Purchasing specifications for three types of distribution transformers are presented. The specifications were compiled by the Canadian Electricity Association at the suggestion made in 1989 by the Canadian Utilities Material Management Group. The specifications cover pole mounted single phase distribution transformers (DTWG-01), low-profile, single phase, dead-front pad-mounted distribution transformers (DTWG-02), and three phase, dead-front pad-mounted distribution transformers (DTWG-03). The specifications were compiled by a task force of CEA member utilities, using CSA standards as the governing standards in all three cases. The first edition of the purchasing specifications was issued in 1993. The second edition, consisting mainly of revisions based on experiences learned from using the first edition, and the addition of the appropriate clauses of CSA standards, was published in 1998. Based on a three-year average of the number of transformers purchased annually (about 58,000) at an estimated total cost of $ 120 million, use of the Purchasing Specifications is said to have resulted in savings of about 7 per cent or $ 8.4 million

  17. The use and evolution of the CEA research reactors

    International Nuclear Information System (INIS)

    The authors successively examine the different research reactors in use in the French C.E.A. Nuclear Centres. They trace briefly their histories, describing how they have been used up to the present, and how they have been adapted to changes in programme by means of certain modifications. They also describe the reasons which have led to the elaboration of the project for the new reactor Osiris. Zoe, the oldest reactor in the CEA, has been in service in the Centre de Fontenay-aux-Roses since 1948. It is used mainly for measurements of absorption cross-sections in graphite, and for various short irradiations which do not require high fluxes. The reactor EL 2, in service since 1952, was used for the first studies on gas cooling. It has also been widely used for the production of radioisotopes and for a large number of experiments in the fields of physics, metallurgy and physical chemistry. The ageing of certain elements of the reactor has led to the decision to close it down in the near future The reactor EL 3 has been widely used for experiments in physics and in the investigation of fuels. The possibilities of the reactor in fast neutron irradiations will be considerably improved by the adoption of a new type of core (the 'snow crystal' structure). Triton-I, a 2 MW swimming-pool reactor, is used for the most part for fast neutron and gamma irradiations. The modifications being carried out on it at present should result in an increase in the power of the reactor up to 4 or 5 MW. In a neighbouring compartment is housed Triton-II which is of the same general structure, as Triton-I, but whose maximum power is 100 kW. Triton-II is used solely for studies on shielding. Melusine, a 2 MW swimming-pool reactor, has been in use in the Centre d'Etudes Nucleaires de Grenoble since 1959. It has supported a very high programme concerned mainly with solid state physics, fundamental research into refractory fissile materials and special graphites, and the study of the behaviour of

  18. The possibility of complementary CEA/PSI physics experiments

    International Nuclear Information System (INIS)

    The zero-power, PROTEUS, is a versatile critical facility for providing integral data to test calculational methods and data used in the neutronics design of standard and advanced reactor systems. An experimental programme is planned for PROTEUS with the main aim to support the Swiss nuclear power plants in questions addressing the neutron physics of new, highly heterogeneous BWR fuel-assemblies in order to reduce the conservations included in the margins to operational limits, on the one hand, as well as special investigations in MOX recycling LWR cores, on the other hand. A second objective considers R+D-contributions to the neutron physics of advanced LWR fuel cycles. In recent years, experiments relating to MOX recycling in PWRs have been performed on the EOLE facility at the Nuclear Research Centre in Cadarache. A five years programme is now planned for the EOLE facility with the aim to study and validate 100% MOX fuel recycling in PWRs. Some experiments will be performed in the PROTEUS facility in co-operation with CEA to complement the measurements in the EOLE facility, addressing questions such as: - intercomparison of standard experimental techniques to reduce systematic errors, - data validation through measurements of non-standard reaction rates in normal, under- and over-moderated LWR-spectra, - void simulation experiments using special techniques, - studies on the reduction of radiation damage on the reactor pressure vessel for 100% MOX cores, by introducing steel baffles between the core boundary and the reactor pressure vessel. (author) 2 figs., 10 refs

  19. The contract State-CEA 2001-2004 for the civil activities; Le contrat etat-Cea 2001-2004 pour les activites civile

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-02-19

    The 25 january 2001, the CEA signed its pluri-annual contract with the State. Apply some to the complete document, this paper deals with the part concerning the energy. The main objective concerns the radioactive wastes management and the mastership of the nuclear activities impacts. The other part is devoted to the research programs and the technology for the industrial innovation. In this framework the CEA have to develop its program on the new following technologies: hydrogen and fuel cells, photovoltaic and storage, energy conservation. A part of the contract concerns also the fundamental research on spallation and transmutation. (A.L.B.)

  20. Anti-CEA loaded maghemite nanoparticles as a theragnostic device for colorectal cancer

    Directory of Open Access Journals (Sweden)

    Campos da Paz M

    2012-10-01

    Full Text Available Mariana Campos da Paz,1 Maria de Fátima M Almeida Santos,1 Camila MB Santos,2 Sebastião W da Silva,2 Lincoln Bernardo de Souza,3 Emília CD Lima,3 Renata C Silva,1 Carolina M Lucci,1 Paulo César Morais,2 Ricardo B Azevedo,1 Zulmira GM Lacava11Instituto de Ciências Biológicas; 2Instituto de Física, Universidade de Brasília, Brasília, DF, Brazil; 3Instituto de Química, Universidade Federal de Goiás, Goiânia, GO, BrazilAbstract: Nanosized maghemite particles were synthesized, precoated (with dimercaptosuccinic acid and surface-functionalized with anticarcinoembryonic antigen (anti-CEA and successfully used to target cell lines expressing the CEA, characteristic of colorectal cancer (CRC cells. The as-developed nanosized material device, consisting of surface decorated maghemite nanoparticles suspended as a biocompatible magnetic fluid (MF sample, labeled MF-anti-CEA, was characterized and tested against two cell lines: a high-CEA expressing cell line (LS174T and a low-CEA expressing cell line (HCT116. Whereas X-ray diffraction was used to assess the average core size of the as-synthesized maghemite particles (average 8.3 nm in diameter, dynamic light scattering and electrophoretic mobility measurements were used to obtain the average hydrodynamic diameter (550 nm and the zeta-potential (−38 mV of the as-prepared and maghemite-based nanosized device, respectively. Additionally, surface-enhanced Raman spectroscopy (SERS was used to track the surface decoration of the nanosized maghemite particles from the very first precoating up to the attachment of the anti-CEA moiety. The Raman peak at 1655 cm−1, absent in the free anti-CEA spectrum, is the signature of the anti-CEA binding onto the precoated magnetic nanoparticles. Whereas MTT assay was used to confirm the low cell toxicity of the MF-anti-CEA device, ELISA and Prussian blue iron staining tests performed with both cell lines (LS174T and HCT116 confirm that the as-prepared MF-anti-CEA

  1. Network and system diagrams revisited: Satisfying CEA requirements for causality analysis

    International Nuclear Information System (INIS)

    Published guidelines for Cumulative Effects Assessment (CEA) have called for the identification of cause-and-effect relationships, or causality, challenging researchers to identify methods that can possibly meet CEA's specific requirements. Together with an outline of these requirements from CEA key literature, the various definitions of cumulative effects point to the direction of a method for causality analysis that is visually-oriented and qualitative. This article consequently revisits network and system diagrams, resolves their reported shortcomings, and extends their capabilities with causal loop diagramming methodology. The application of the resulting composite causality analysis method to three Environmental Impact Assessment (EIA) case studies appears to satisfy the specific requirements of CEA regarding causality. Three 'moments' are envisaged for the use of the proposed method: during the scoping stage, during the assessment process, and during the stakeholder participation process

  2. Comparison of Ablation Predictions for Carbonaceous Materials Using CEA and JANAF-Based Species Thermodynamics

    Science.gov (United States)

    Milos, Frank S.

    2011-01-01

    In most previous work at NASA Ames Research Center, ablation predictions for carbonaceous materials were obtained using a species thermodynamics database developed by Aerotherm Corporation. This database is derived mostly from the JANAF thermochemical tables. However, the CEA thermodynamics database, also used by NASA, is considered more up to date. In this work, the FIAT code was modified to use CEA-based curve fits for species thermodynamics, then analyses using both the JANAF and CEA thermodynamics were performed for carbon and carbon phenolic materials over a range of test conditions. The ablation predictions are comparable at lower heat fluxes where the dominant mechanism is carbon oxidation. However, the predictions begin to diverge in the sublimation regime, with the CEA model predicting lower recession. The disagreement is more significant for carbon phenolic than for carbon, and this difference is attributed to hydrocarbon species that may contribute to the ablation rate.

  3. Numerical Platon: A unified linear equation solver interface by CEA for solving open foe scientific applications

    International Nuclear Information System (INIS)

    This paper describes a tool called 'Numerical Platon' developed by the French Atomic Energy Commission (CEA). It provides a freely available (GNU LGPL license) interface for coupling scientific computing applications to various freeware linear solver libraries (essentially PETSc, SuperLU and HyPre), together with some proprietary CEA solvers, for high-performance computers that may be used in industrial software written in various programming languages. This tool was developed as part of considerable efforts by the CEA Nuclear Energy Division in the past years to promote massively parallel software and on-shelf parallel tools to help develop new generation simulation codes. After the presentation of the package architecture and the available algorithms, we show examples of how Numerical Platon is used in sequential and parallel CEA codes. Comparing with in-house solvers, the gain in terms of increases in computation capacities or in terms of parallel performances is notable, without considerable extra development cost

  4. “[…] Non urbs, tamen urbibus ipsa major.” The Image of The Hague in the Dutch Literature and Art of the 17th and 18th Century

    Directory of Open Access Journals (Sweden)

    Polkowski Marcin

    2015-11-01

    Full Text Available Although in the early-modern period The Hague was not officially a city, its identity was based on specifically urban features. During the 17th and 18th century, its ambiguous status was explored by the authors of verse urban encomia and prose descriptiones urbium. In this article, the presentation of The Hague will be first discussed on the example of Caspar Barlaeus’ Latin poem “Haga”, and Constantijn Huygens’ Dutch encomium “’s Gravenhage” from the Dorpen [Villages] cycle of epigrams. Then, the image of The Hague will be examined in the context of an allegorical representation by Jan Caspar Philips in Jacob de Riemer’s Beschryving van ‘s Graven-hage [Description of The Hague, 1730]. The concluding remarks address the question of how the transformation of the status of The Hague undertaken by these writers and artists may be understood in the context of the literary-historical geography of the Northern Renaissance which has been a special subject of research by Professor Andrzej Borowski.

  5. Scientific evaluation at the French Atomic Energy Commission (CEA). 2005-2006 annual report

    International Nuclear Information System (INIS)

    This report aims at presenting the scientific evaluation activities carried out at the CEA during the years 2005-2006. The evaluation system is described in detail. It comprises two aspects: the evaluation of the scientific policy implemented by the scientific Council and by the visiting committee of the CEA, and the evaluation of the laboratories, performed by a pool of 36 scientific councils. The evaluation by external and independent parties is the key point of this system. This document makes a status of the evaluations performed in 2005 and 2006. It presents a synthesis of the conclusions of the evaluation authorities. The actions implemented by the CEA to take into consideration the recommendations are also reported with the improvements noticed. The two topics examined by the scientific Committee and by the visiting committee were dealing with the energy domain, which is a strategic issue for the CEA. The examination of the researches on future nuclear reactors and on new energy technologies have shown the major role played by the CEA in the recent advances in these domains. About 95% of the laboratories activity was examined during the 2002-2005 period. The richness of the remarks and recommendations made by the scientific councils should allow the CEA to improve the quality and relevance of its research works. The start-up of the 2006-2009 evaluation cycle has been the occasion to modify the evaluation of some research domains in order to take into account the evolution of programs. The evaluation system of the CEA is highly consistent with the AERES principles. Its implementation, adapted to each type of activity (fundamental research, applied research, technological developments) allows the CEA to follow up a permanent improvement approach. (J.S.)

  6. Summary 1998. Releases control and environment monitoring for the CEA Centers

    International Nuclear Information System (INIS)

    In the framework of its environmental policy, the CEA aims at reduce as weak as possible, in regards to the technological and economic needs, its activities impacts on the people and the environment. This paper contributes to the public information on the radioactive gaseous and liquid releases during the year 1998. It presents data on the releases and the radioactivity levels around the CEA sites and gathers the associated regulation and monitoring methods. (A.L.B.)

  7. Integral needs for MOX powders: state of the art at Cea Cadarache on MOX fuel experiments

    International Nuclear Information System (INIS)

    Several experimental programmes have been conducted at CEA connected with the use of MOX in commercial PWR or innovative concepts, such as high conversion light water reactors (HCLWRs) and at various moderation ratios. Measurements of integral parameters of interest were performed using fission chambers and gamma-scanning techniques, or by oscillation techniques. This paper presents an overview of the experimental programmes performed at the EOLE and MINERVE facilities located at CEA Cadarache. (author)

  8. Unusual elevation of CEA in a patient with history of colon cancer.

    Science.gov (United States)

    Hsu, Tzu-Chi

    2006-12-01

    A 35-year-old female received right hemicolectomy for a poorly differentiated adenocarcinoma of the ascending colon with lymph node metastasis (1/28) in February 1997. CEA was 1.68 ng/microl prior to colectomy. Adjuvant chemotherapy with weekly 5-FU and leucovorin intravenously was started following surgery and discontinued after 17 doses in May 1997. She received bilateral salpingo-ophorecctomy for metastatic cancer in August 1999. Intravenous chemotherapy was resumed with weekly 5-FU and leucovorin intravenously in August 1999. CEA was 93.8 ng/microl in November 1999. Intravenous chemotherapy was discontinued after 20 doses and oral chemotherapy with futraful and leucovorin was started in January 2000. CEA was found to be 240.3 ng/microl in December 1999 and then elevated to 1521.3 ng/microl in June 2001, which was 10 months after resection of metastatic ovarian cancer. No metastatic lesions could be detected, however, with image studies. The CEA decreased to 396.6 ng/microl three months later. Futraful was switched to uracil-tegafur (UFUR) in September 2001. The CEA for the patient ranged from 68.5 to 298.9 ng/microl for the following 5 years without aggressive chemotherapy. No evidence of recurrence could be demonstrated by imaging studies. The patient is not a smoker and denied exposure to a smoking environment. She was also not known to have persistent infections, inflammatory bowel disease, pancreatitis, cirrhosis of the liver, or any benign tumors. The current case suggested that: (i) elevation of CEA is not necessarily well correlated with presence of metastatic colon cancer; (ii) some patients may live with elevated CEA for years without evidence of recurrence or metastasis; (iii) aggressive chemotherapy may not be necessary in patients with only elevated CEA. PMID:17060406

  9. Blood CEA levels for detecting recurrent colorectal cancer: A Diagnostic Test Accuracy Review.

    OpenAIRE

    Nicholson, BD; Shinkins, B.; Pathiraja, I; Roberts, NW; James, T; Mallett, S.; Perera, R; Primrose, JN; Mant, D

    2015-01-01

    Background Testing for carcino-embryonic antigen (CEA) in the blood is a recommended part of follow-up to detect recurrence of colorectal cancer following primary curative treatment. There is substantial clinical variation in the cut-off level applied to trigger further investigation. Objectives To determine the diagnostic performance of different blood CEA levels in identifying people with colorectal cancer recurrence in order to inform clinical practice. Search methods W...

  10. Elevated Level of Serum Carcinoembryonic Antigen (CEA) and Search for a Malignancy: A Case Report.

    Science.gov (United States)

    Asad-Ur-Rahman, Fnu; Saif, Muhammad W

    2016-01-01

    Carcinoembryonic antigen (CEA) has been shown to be associated with tumor burden in patients with colorectal cancer. However, it is also elevated to a significant degree in a number of other malignant and non-malignant conditions. We report a case of reversible CEA elevation in a patient using lithium for bipolar disorder. A 58-year-old female with a longstanding smoking history and a past medical history of chronic obstructive pulmonary disease (COPD), bipolar illness, hypothyroidism, and obesity was found to have an elevated CEA level of 11.2 ng/ml (normal level studies to evaluate for colorectal, breast, ovarian, and lung cancer; however, it did not reveal any evidence of malignancy. Upon review of her medications, she reported that she had recently started lithium for her bipolar illness. We followed up her CEA level while her dose of lithium was reduced from 450 to 300 mg per day. Her CEA level decreased from 25 mg/dl to 6.1 mg/dl and remained stable over the course of the next eight months. Our case is the first case report that identifies lithium as a potential cause of reversible CEA elevation. The underlying mechanism is yet to be elucidated, but it underscores the importance of investigating the medications as part of the workup. PMID:27446768

  11. The Hague Convention on Protection of Children and Co-operation in Respect of Inter-country Adoption: Seeking the Cultural Relativism of the Inter-country Adoption

    OpenAIRE

    Šklebená, Karolína

    2011-01-01

    This thesis focuses on the rights of the child in respect to the inter-country adoption. It aims to seek the notions of cultural relativism within those fundamental rights which are immediately applicable on the process of adoption. The thesis bases its theoretical framework on the current discourse on the universality of human rights. The theory of the three levels of cultural relativism is applied on the Hague Convention on Protection of Children and Co-operation in Respect of Inter-country...

  12. International parental child abduction - grounds for refusal of return: Human Rights & The Hague Convention on the Civil Aspects of International Child Abduction

    OpenAIRE

    Svanhildur Ýr Sigþórsdóttir 1985

    2010-01-01

    The focus of this thesis is to see whether the Courts, judging under the Hague Convention on the Civil Aspects of International Child Abduction, take the Convention on the Rights of the Child into consideration, when deciding upon the return of the child to his or her habitual residence. The Convention on the Rights of the Child has the child’s best interests as a priority. States Parties to the Convention are to take measures, combating the illicit transfer and the non-return of children...

  13. Historia natural cuantitativa de una relación parásito-hospedero: el sistema Tristerix-cactáceas en Chile semiárido Quantitative natural history of a host-parasite relationship: the Tristerix-cactus system in semiarid Chile

    OpenAIRE

    RODRIGO MEDEL; CAREZZA BOTTO-MAHAN; CECILIA SMITH-RAMÍREZ; Méndez, Marco A.; CARMEN G. OSSA; LUCIANO CAPUTO; Gonzáles, Wilfredo L.

    2002-01-01

    Presentamos información cuantitativa de la historia natural de la relación parásito-hospedero constituida por el muérdago holoparásito Tristerix aphyllus (Loranthaceae) y sus hospederos cactáceas. Más específicamente, indagamos en los determinantes históricos y biogeográficos de la interacción y cuantificamos la autoecología de la biología floral, polinización, dispersión y parasitismo en este sistema. El impacto del parasitismo sobre la evolución de sistemas defensivos en las cactáceas hospe...

  14. Evaluación del riesgo de extinción de Mammillaria pectinifera, cactácea endémica de la región de Tehuacán-Cuicatlán Assessment of extinction risk of Mammillaria pectinifera, an endemic cactus of the Tehuacán-Cuicatlán region

    Directory of Open Access Journals (Sweden)

    Pedro Luis Valverde

    2009-04-01

    Full Text Available Mammillaria pectinifera (Cactaceae es una especie endémica de la Región de Tehuacán-Cuicatlán en los estados de Puebla y Oaxaca. Aunque en la Norma Oficial Mexicana NOM-059-ECOL-2001 está considerada como amenazada y está incluida en el Apéndice I de la CITES, la información derivada de los escasos estudios ecológicos sobre esta especie revela serios riesgos de extinción de sus poblaciones. En el presente estudio se registra una evaluación del riesgo de extinción de M. pectinifera, para la que se empleó el protocolo del Método de Evaluación del Riesgo de Extinción de las Especies Silvestres en México (MER del Anexo I de la NOM-059-ECOL-2001, el cual se basa en 4 criterios para evaluar cualitativamente el riesgo de extinción de cualquier especie silvestre en el territorio nacional. Dicha evaluación se apoya en datos de campo de 7 poblaciones e información procedente de diversas fuentes. De acuerdo con los 12 puntos obtenidos del MER, se propone que M. pectinifera se considere en la categoría de especie en peligro de extinción (P en la NOM-059-ECOL-2001 y sea incluida de nuevo en la Lista Roja de la UICN. Finalmente se plantea una propuesta para mejorar la valoración del Criterio D del MER.Mammillaria pectinifera (Cactaceae is an endemic species from the Tehuacán-Cuicatlán region at the Mexican States of Puebla and Oaxaca. Although it is considered as a threatened species under Mexican law NOM-059-ECOL-2001, and it is already included in the CITES Appendix I, ecological studies reveal serious vulnerability to extinction of its populations. In this study, we conducted an extinction risk assessment for M. pectinifera based on the protocol of the Method for Evaluation of Risk of Extinction for Mexican Wild Species (MER from Appendix I of NOM-059-ECOL-2001, which is based on a qualitative assessment of 4 criteria for evaluating extinction risk of any wild species in the Mexican territory. The present assessment relies on data

  15. Situation 2002: release monitoring and surveillance of environment of Cea centers; Bilan 2002: controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This publication renders an account of the situation of the releases of liquid and gaseous radioactive effluents, for the year 2002, as well as the radioactivity levels measured in the vicinity of Cea centers through the systematic surveillance of atmosphere, waters, vegetation and milk. An analysis on five years allows to follow their evolution. (N.C.)

  16. Melanoma cell surface-expressed phosphatidylserine as a therapeutic target for cationic anticancer peptide, temporin-1CEa.

    Science.gov (United States)

    Wang, Che; Chen, Yin-Wang; Zhang, Liang; Gong, Xian-Ge; Zhou, Yang; Shang, De-Jing

    2016-07-01

    We have previously reported that temporin-1CEa, a cationic antimicrobial peptide, exerts preferential cytotoxicity toward cancer cells. However, the exact molecular mechanism for this cancer-selectivity is still largely unknown. Here, we found that the negatively charged phosphatidylserine (PS) expressed on cancer cell surface serves as a target for temporin-1CEa. Our results indicate that human A375 melanoma cells express 50-fold more PS than non-cancerous HaCaT cells. The expression of cell surface PS in various cancer cell lines closely correlated with their ability to be recognized, bound and killed by temporin-1CEa. Additionally, the cytotoxicity of temporin-1CEa against A375 cells can be ameliorated by annexin V, which binds to cell surface PS with high affinity. Moreover, the data of isothermal titration calorimetry assay further confirmed a direct binding of temporin-1CEa to PS, at a ratio of 1:5 (temporin-1CEa:PS). Interestingly, the circular dichroism spectra analysis using artificial biomembrane revealed that PS not only provides electrostatic attractive sites for temporin-1CEa but also confers the membrane-bound temporin-1CEa to form α-helical structure, therefore, enhances the affinity and membrane disrupting ability of temporin-1CEa. In summary, these findings suggested that the melanoma cells expressed PS may serve as a promising target for temporin-1CEa or other cationic anticancer peptides. PMID:26596643

  17. Fijación biológica de nitrógeno por tres fabáceas (Leguminosae) en suelos ácidos de Tabasco, México

    OpenAIRE

    S. Córdova-Sánchez; M. Castelán-Estrada; S. Salgado-García; J. D. Palma-López; J. A. Vera-Núñez; J. J. Peña-Cabriales; L. C. Lagunes-Espinoza; R. Cárdena-Navarro

    2011-01-01

    Con el objetivo de determinar el potencial de fijación biológica de nitrógeno por las fabáceas Cajanus cajan L., Canavalia ensiformis L. y Mucuna deerengiana L., en rotación y asociación con maíz durante dos ciclos de cultivo, se desarrollaron dos experimentos en un suelo ácido de la sabana de Huimanguillo, Tabasco. En ambos sistemas se evaluaron variables relacionadas con la nodulación de estas fabáceas, así como su efecto sobre el rendimiento de maíz (Zea mays L.); también se cuantificó ...

  18. Fijación biológica de nitrógeno por tres fabáceas (Leguminosae) en suelos ácidos de Tabasco, México

    OpenAIRE

    S. Córdova-Sánchez; M. Castelán-Estrada; S. Salgado-García; J. D. Palma-López; J. A. Vera-Núñez; J. J. Peña-Cabriales; L. C. Lagunes-Espinoza; R. Cárdena-Navarro

    2011-01-01

    Con el objetivo de determinar el potencial de fijación biológica de nitrógeno por las fabáceas Cajanus cajan L., Canavalia ensiformis L. y Mucuna deerengiana L., en rotación y asociación con maíz durante dos ciclos de cultivo, se desarrollaron dos experimentos en un suelo ácido de la sabana de Huimanguillo, Tabasco. En ambos sistemas se evaluaron variables relacionadas con la nodulación de estas fabáceas, así como su efecto sobre el rendimiento de maíz (Zea mays L.); también se cuantificó el ...

  19. Construction of CEA siRNA expression vector and its inhibitory effects on the expression of CEA in EC9706 cells%CEA siRNA载体的构建和转染人食管癌EC9706细胞的沉默作用

    Institute of Scientific and Technical Information of China (English)

    Guoqiang Zhao; Sajia Sun; Hong Zheng; Long Feng; Hongyan Yang; Ziming Dong

    2008-01-01

    Objective: To construct the small interfering RNA (siRNA) expression vector of carcino-embryonic antigen (CEA) and inhibit the expression of CEA in EC9706 cells by RNA interference. Methods: Two pairs of oligonucleotide sequences were designed and synthesized according to the encoding sequence of mRNA of CEA. The annealed oligonucleotide fragments were cloned into pRNAT-U6.2 expression vector and identified by sequencing. The recombinant plasmid pRNAT-U6.2-CEA was transfected into EC9706 cells. The expression of CEA in the stable transfected cells was assayed by real time PCR and Western blot. Results: DNA sequencing showed that the oligonucleotide fragments were correctly inserted into pRNAT-U6.2 vector, and CEA expression in the transfected cells was down-regulated significantly by pRNAT-U6.2-CEA at both the mRNA and protein levels. Conclusion: The siRNA expression vector of CEA is successfully constructed and inhibits CEA expression in EC9706 cells. This facilitates further studies of the function of CEA at the molecular level.

  20. Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein

    International Nuclear Information System (INIS)

    CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. The human MA39 scFv, selected for its ability to recognize a CEA epitope expressed on human colon carcinomas, was first isolated from a large semi-synthetic ETH-2 antibody phage library, panned on human purified CEA protein. Subsequently, by in vitro mutagenesis of a gene encoding for the scFv MA39, a new library was established, and new scFv antibodies with improved affinity towards the CEA cognate epitope were selected and characterized. The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells. The binding affinity of the scFv E8 is in a range for efficient, in vivo, antigen capture in tumor cells expressing a shared epitope of the CEACAM1, 3 and 5 proteins. This new immunoreagent meets all criteria for a potential anticancer compound: it is human, hence poorly or not at all immunogenic, and it binds selectively and with good affinity to the CEA epitope expressed by metastatic melanoma and colon and lung carcinomas. Furthermore, its small molecular size should provide for efficient tissue penetration, yet give rapid plasma clearance

  1. Evaluation of the reliability concerning the identification of human factors as contributing factors by a computer supported event analysis (CEA)

    International Nuclear Information System (INIS)

    The project's objectives are the evaluation of the reliability concerning the identification of Human Factors as contributing factors by a computer supported event analysis (CEA). CEA is a computer version of SOL (Safety through Organizational Learning). Parts of the first step were interviews with experts from the nuclear power industry and the evaluation of existing computer supported event analysis methods. This information was combined to a requirement profile for the CEA software. The next step contained the implementation of the software in an iterative process of evaluation. The completion of this project was the testing of the CEA software. As a result the testing demonstrated that it is possible to identify contributing factors with CEA validly. In addition, CEA received a very positive feedback from the experts. (orig.)

  2. Bignoniáceas nuevas o notables de colombia

    OpenAIRE

    2012-01-01

    En este trabajo se señalan por primera vez en la flora de Colombia cuatro géneros (Parmentiera, Roentgenia, scooinaria. y además Pyrostegia en estado silvestre) y varias especies de esta interesante familia botánica; se reduce un taxon recién descrito (Lundia colombiana Dugand) a la sinonimia de Lundia puberula Pittier; se señalan unas cápsulas extraordinariamente largas de Martinella obovata (H.B.K.) Bur. & K. .Schum.; se describe una nueva especie de Parmentiera y otra de Scobinaria, as...

  3. Clinical significance of joint detection of serum CEA, SCCA, and bFGF in the diagnosis of lung cancer

    OpenAIRE

    Zhao, Wei; Yu, Haixiang; Han, Zhifeng; Gao, Nan; Xue, Jinru; Wang, Yan

    2015-01-01

    Lung cancer is a type of malignant tumor with highest morbidity and mortality. This study tested three tumor marker levels including CEA, SCCA, and bFGF to explore their value in lung cancer diagnosis and pathological type judgment. Venous blood was extracted from lung cancer patients, lung benign lesion patients and healthy control. Electrochemiluminescence immunoassay was applied to detect serum CEA and SCCA content. ELISA was used to test serum bFGF level. Serum CEA, SCCA, and bFGF levels ...

  4. How to Add Value to your Business with CEA: A Practical Approach

    Directory of Open Access Journals (Sweden)

    Daniel Cardenas

    2010-04-01

    Full Text Available Companies are always trying to differentiate themselves from the rest of the pack by applying different strategies such as improving customer service, increasing the efficiency of their operations, or reducing their costs. Most of the time, however, these goals are competing against each other for scarce resources, and managers often need to decide to concentrate on one. A small company can effectively and simultaneously accomplish these goals for a fraction of the cost by implementing communications-enabled business processes or solutions, which are a set of technology components that add real-time networking functionality to applications. One particular implementation of this framework is the one provided by Coral CEA. Coral CEA is a business ecosystem anchored around CEA functionalities that are offered as building blocks, out-of-the-box components that link the capabilities and intelligence of networks platforms with the power of current applications to provide a new set of features and functionalities. In this article, we show how a small company called Rezact, located in the ski resort town of Mont-Tremblant, Quebec, successfully implemented CEA capabilities within its own operations using Coral CEA services.

  5. Vulnerabilidad de los sistemas de polinización de cactáceas columnares de México Vulnerability of pollination systems of columnar cacti of Mexico

    Directory of Open Access Journals (Sweden)

    Alfonso Valiente-Banuet

    2002-03-01

    Full Text Available Se presenta un análisis geográfico sobre el grado de vulnerabilidad de los sistemas de polinización de cactáceas columnares de México que muestran un síndrome de polinización quiropterófila. Se partió del supuesto que sistemas especializados de polinización serían más vulnerables a la perturbación humana que los generalistas. Los resultados indican que las especies que se ubican en el límite norte de la distribución de las cactáceas columnares muestran patrones generalistas de polinización que las hace menos vulnerables a las perturbaciones que las que habitan el centro de México que presentan sistemas de interacción especializados. Este patrón contrastante podría estar relacionado con los movimientos migratorios de los murciélagos en el norte de la distribución de las cactáceas que pudo haber restringido la respuesta hacia la especialización, en tanto que poblaciones residentes de murciélagos en el centro de México podrían haber favorecido la especialización localAn analysis of the degree of vulnerability of the pollination systems of Mexican columnar cacti showing a chiropterophyllous pollination syndrome was conducted, assuming that specialized pollination interactions would be more vulnerable to human perturbations. The results indicate that the species inhabiting the northern distribution limit of the columnar cacti show generalized pollination systems whereas species inhabiting central Mexico showing specialized pollination interactions would be more vulnerable to perturbations. This contrasting geographic pattern might be related to the migratory movements of the nectar-feeding bats in the northern limit of distribution of the columnar cacti that restricted local specialization, whereas resident nectar-feeding bat populations in south-central Mexico probably favored local specialization

  6. Distribución, abundancia y estructura poblacional del langostino rojo de profundidad Haliporoides diomedeae (Crustácea: Decapoda: Solenoceridae frente a la zona norte de Perú (2007-2008 Distribution, abundance, and population structure of deep red shrimp Haliporoides diomedeae (Crustacea: Decapoda: Solenoceridae off northern Peru (2007-2008

    Directory of Open Access Journals (Sweden)

    Edward Barriga

    2009-01-01

    Full Text Available Se determinó la distribución, abundancia relativa y estructura poblacional de Haliporoides diomedeae frente a la zona norte de Perú (3°30'S-10°00'S, con los resultados de dos cruceros desarrollados en 2007 y 2008 a bordo del B/O Miguel Oliver, que realizó investigaciones de la fauna bentodemersal entre 200 y 1.500 m de profundidad, mediante un muestreo al azar estratificado de arrastre de fondo. En 122 lances realizados en cuatro sectores y tres estratos se capturó un total de 48.056 kg, compuestos por ~347 especies de peces e invertebrados. H. diomedeae fue la especie de langostino más importante en las capturas (411 kg, con los mayores niveles de abundancia entre 600 y 1.600 m al norte de los 7°S, con valores medios de captura por unidad de área (CPUA entre 83,4 y 211 kg km-2 y una biomasa total estimada de 1.139,74 ton (± 245,6 ton. Las hembras presentaron una longitud cefalotorácica media de 40,6 mm, rango de 14,5 y 74,5 mm y grupo modal dominante de 30 mm, mientras que en los machos la media fue de 30,6 mm, rango 16 a 33 mm y grupo modal principal de 27 mm; para ambos sexos se identificaron seis grupos modales, dimorfismo sexual y gradiente batimétrica. La relación talla-peso fue de tipo alométrico. En general, las características de distribución, abundancia y estructura poblacional de H. diomedeae permiten considerarla como una especie potencialmente explotable en el norte del mar peruano.The distribution, relative abundance, and population structure of Haliporoides diomedeae was determined off northern Peru (3°30'S-10°00'S by analyzing data from two cruises carried out in 2007 and 2008 on board the B/O Miguel Oliver to assess the bentho-demersal fauna between 200 and 1,500 m depth, us-ing a stratified random bottom trawl design. The total catch from the 122 hauls (covering four sectors and three strata was 48,056 kg, with ~347 fish and invertebrate species. H. diomedeae was the most important shrimp in the catches (411

  7. Diferencias en la flora herbácea y arbustiva entre claros y áreas bajo dosel en un bosque de Nothofagus pumilio en Argentina Differences in the herb and shrub flora growing under canopy gaps and under closed canopies in a Nothofagus pumilio forest of Argentina

    Directory of Open Access Journals (Sweden)

    M. ANGÉLICA DAMASCOS

    2002-09-01

    Full Text Available Se comparó la distribución de las hierbas y arbustos bajo el dosel y en dos tamaños de claros del bosque deciduo de Nothofagus pumilio de Argentina. La riqueza total y promedio de especies por cuadrado fueron similares bajo el dosel y en los claros pequeños (diámetro mayor The distribution of herbs and shrubs under closed canopies and in two canopy gaps of different size was compared in a Nothofagus pumilio deciduous forest of Argentina. The total and the average species richness per plot were similar between the areas under the canopy and in small (maximum diameter < 5 m and medium size gaps (maximum diameter 5-10 m. Generalist species were the most numerous (46 %, while obligate and facultatively shade-tolerant (heliophobous and intolerant (heliophilous species accounted for 19 and 15 % of the species, respectively. The absence of differences in species richness may be attributed to: (1 high frequency of generalist species (2 low effect of gap formation on shade-tolerant species distribution, (3 persistence of facultatively shade-tolerant species in small gaps, (4 gap invasion by obligate shade-intolerant species. The heterogeneity of light environment beneath the canopy and the effects on gap microclimate of edge trees and gap shrubs are possible causes of these patterns. Although with variations between the different biological groups, forest species are probably tolerant to the low level of disturbance generated by the natural forest dynamics

  8. Technetium-99m labelling of the ior-CEA-1 monoclonal antibody: Evaluation of different methods

    International Nuclear Information System (INIS)

    In the present work, we evaluated the influence of experimental conditions on the characteristics of the radiolabelled ior-CEA-1 prepared by direct method, using 2-ME and stannous chloride as reductants and indirect method in which 2-IM is used to generate sulfhydryl groups in the protein. The following parameters were studied: number of free sulfhydryl groups of treated antibody, labelling efficiency, chemical and radiochemical composition of the radiolabelled antibodies as well as their immunological and biological properties. The properties of 99Tcm-ior-CEA-1 obtained by 2-ME method were compared to the ones of the 99Tcm-monoclonal antibody obtained from a commercial kit (BW 431/26). Some clinical studies using 99Tcm-ior-CEA-1 were also performed

  9. Updated on effluents releases of the CEA nuclear fuel cycle facilities - 1995 to 2010 period

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Nelson Luiz Dias [Centro Tecnologico da Marinha em Sao Paulo (CTMSP) Sao Paulo, SP (Brazil)

    2011-07-01

    The environmental impact assessment of the Centro Experimental Aramar (CEA) facilities has been presented in a former work, based on the measured effluent releases data, for the period from 1995 to 2007. This work shows the update up to 2010. The effluents releases to the environment result from the routine operation of CEA nuclear fuel cycle facilities (LEI - Isotopic Enrichment Laboratory, USIDE - Pilot Plant for Industrial Verification of Uranium Enrichment and LABMAT - Nuclear Materials Laboratory). Basically, this work presents the radioactive release source terms, as described at the CEA Effluent Report sent to the National Commission for Nuclear Energy (CNEN) each semester, and a historical assessment of the critical group annual doses from 1995 up to 2010. The assessed doses are compared to the maximum dose constraint as well as to the exemption level specified by CNEN. (author)

  10. Chemistry of complexing molecules and environment. Report of the working group of the Cea ''mission environment''

    International Nuclear Information System (INIS)

    The Working group 'Chemistry of Complexing Molecules and Environment' of the Mission Environment (AG/ENV) identified themes for an original positioning of CEA on important issues of environmental research if a sufficiently strong demand appears. The research of CEA on the environment should be complementary to actions undertaken by other partners (official institutions, research organizations and industrial firms). The themes suggested are: the synthesis of new chelating molecules and new materials having specific properties, with the support of theoretical chemistry and modeling, analytical physical chemistry and speciation of species in relation to their eco-toxicity and their biogeochemical mobility in the natural environment. These themes, illustrated by examples of actions in progress at CEA or likely to be launched quickly, draw largely from recognized competences of the teams, generally developed for finalized nuclear applications: experimental, theoretical and instrumental competences. (author)

  11. Development of radiopharmaceuticals based on aptamers: selection and characterization of DNA aptamers for CEA

    Energy Technology Data Exchange (ETDEWEB)

    Correa, C.R.; Andrade, A.S.R., E-mail: antero@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Augusto-Pinto, L. [BioAptus, Belo Horizonte, MG (Brazil); Goes, A.M., E-mail: goes@icb.ufmg.br [Departamento de Imunologia e Bioquimica. Instituto de Ciencias Biologicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG (Brazil)

    2011-07-01

    Colorectal cancer is among the top four causes of cancer deaths worldwide. Carcinoembryonic antigen (CEA) is a complex intracellular glycoprotein produced by about 90% of colorectal cancers. CEA has been identified as an attractive target for cancer research because of its pattern of expression in the surface cell and its likely functional role in tumorigenesis. Research on the rapid selection of ligands based on the SELEX (systematic evolution of ligands by exponential enrichment) forms the basis for the development of high affinity and high specificity molecules, which can bind to surface determinants of tumour cells, like CEA. The oligonucleotides ligands generated in this technique are called aptamers. Aptamers can potentially find applications as therapeutic or diagnostic tools for many kind of diseases, like a tumor. Aptamers offer low immunogenicity, good tumour penetration, rapid uptake and fast systemic clearance, which favour their application as effective vehicles for radiotherapy. In addition aptamers can be labeled with different radioactive isotopes. The aim of this work was select aptamers binding to the CEA tumor marker. The aptamers are obtained through by SELEX, in which aptamers are selected from a library of random sequences of synthetic DNA by repetitive binding of the oligonucleotides to target molecule (CEA). Analyses of the secondary structure of the aptamers were determined using the m fold toll. Three aptamers were selected to binding assay with target cells. These aptamers were confirmed to have affinity and specific binding for T84 cell line (target cell), showed by confocal imaging. We are currently studying the potential efficacy of these aptamers as targeted radiopharmaceuticals, for use as imaging agents or therapeutic applications. The development of aptamers specific to CEA open new perspectives for colorectal cancer diagnosis and treatment. Acknowledgments: This investigation was supported by the Centro de Desenvolvimento da

  12. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa.

    Science.gov (United States)

    Muenzner, Petra; Kengmo Tchoupa, Arnaud; Klauser, Benedikt; Brunner, Thomas; Putze, Johannes; Dobrindt, Ulrich; Hauck, Christof R

    2016-05-01

    Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA) family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa) proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa. PMID:27171273

  13. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa.

    Directory of Open Access Journals (Sweden)

    Petra Muenzner

    2016-05-01

    Full Text Available Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa.

  14. Development of radiopharmaceuticals based on aptamers: selection and characterization of DNA aptamers for CEA

    International Nuclear Information System (INIS)

    Colorectal cancer is among the top four causes of cancer deaths worldwide. Carcinoembryonic antigen (CEA) is a complex intracellular glycoprotein produced by about 90% of colorectal cancers. CEA has been identified as an attractive target for cancer research because of its pattern of expression in the surface cell and its likely functional role in tumorigenesis. Research on the rapid selection of ligands based on the SELEX (systematic evolution of ligands by exponential enrichment) forms the basis for the development of high affinity and high specificity molecules, which can bind to surface determinants of tumour cells, like CEA. The oligonucleotides ligands generated in this technique are called aptamers. Aptamers can potentially find applications as therapeutic or diagnostic tools for many kind of diseases, like a tumor. Aptamers offer low immunogenicity, good tumour penetration, rapid uptake and fast systemic clearance, which favour their application as effective vehicles for radiotherapy. In addition aptamers can be labeled with different radioactive isotopes. The aim of this work was select aptamers binding to the CEA tumor marker. The aptamers are obtained through by SELEX, in which aptamers are selected from a library of random sequences of synthetic DNA by repetitive binding of the oligonucleotides to target molecule (CEA). Analyses of the secondary structure of the aptamers were determined using the m fold toll. Three aptamers were selected to binding assay with target cells. These aptamers were confirmed to have affinity and specific binding for T84 cell line (target cell), showed by confocal imaging. We are currently studying the potential efficacy of these aptamers as targeted radiopharmaceuticals, for use as imaging agents or therapeutic applications. The development of aptamers specific to CEA open new perspectives for colorectal cancer diagnosis and treatment. Acknowledgments: This investigation was supported by the Centro de Desenvolvimento da

  15. An Information Building on Radioactivity and Nuclear Energy for the French CEA Cadarache Research Center - 13492

    International Nuclear Information System (INIS)

    The CEA Cadarache research center is one of the 10 research centers of the French Alternative Energies and Atomic Energy Commission (CEA). Distributed throughout various research platforms, it focuses on nuclear fission, nuclear fusion, new energy technologies (hydrogen, solar, biomass) and fundamental research in the field of vegetal biology. It is the most important technological research and development centers for energy in Europe. Considering the sensitive nature of nuclear activities, the questions surrounding the issue of radioactive waste, the nuclear energy and the social, economic and environmental concerns for present and future generations, the French Government asked nuclear actors to open communication and to give all the information asked by the Local Information Commission (CLI) and the public [1]. In this context, the CEA Cadarache has decided to better show and explain its expertise and experience in the area of nuclear energy and nuclear power plant design, and to make it available to stakeholders and to the public. CEA Cadarache receives each year more than 9000 visitors. To complete technical visits of the research facilities and laboratories, a scientific cultural center has been built in 2011 to inform the public on CEA Cadarache research activities and to facilitate the acceptance of nuclear energy in a way suited to the level of knowledge of the visitors. A modern interactive exhibition of 150 m2 allows visitors to find out more about energy, CEA Cadarache research programs, radioactive waste management and radiological impact on the research center activities. It also offers an auditorium for group discussions and for school groups to discover science through enjoyment. This communication center has received several thousand visitors since its opening on October 2011; the initial results of this experience are now available. It's possible to explain the design of this exhibition, to give some statistics on the number of the visitors, their

  16. Prognostic value of monitoring tumour markers CA 15-3 and CEA during fulvestrant treatment

    International Nuclear Information System (INIS)

    At many centres tumour markers are used to detect disease recurrence and to monitor response to therapy in patients with advanced disease, although the real value of serial observation of marker levels remains disputed. In this study, we evaluated the prognostic value of tumour markers for predicting response (partial response [PR], stable disease [SD] ≥ 6 months), de novo disease progression (PD) and secondary PD in patients receiving fulvestrant ('Faslodex') 250 mg/month for the treatment of metastatic breast cancer (MBC). Changes in cancer antigen 15–3 (CA 15-3) and carcinoembryonic antigen (CEA) were prospectively monitored (monthly) and were also evaluated for the 3 months preceding secondary PD. Data from 67 patients with previously treated MBC participating in a Compassionate Use Programme were analysed. In patients with a PR (n = 7 [10.4%]), a non-significant increase in CA 15-3 occurred during the first 6 months of treatment; CEA was significantly reduced (P = 0.0165). In patients with SD ≥ 6 months (n = 28 [41.8%]), both CA 15-3 (P < 0.0001) and CEA (P = 0.0399) levels increased significantly after 6 months treatment. In those experiencing de novo PD (n = 32 [47.8%]), CA 15-3 increased significantly (P < 0.0001) after 4 months; CEA also increased significantly (P = 0.0002) during the same time period. Both CA 15-3 (P < 0.0001) and CEA (P < 0.0001) increased significantly in the 3 months preceding secondary PD. CA 15-3 increases in patients progressing on fulvestrant but may also increase in those experiencing clinical benefit; this should not be taken as a sign of PD without verification. Overall, both CA 15-3 and CEA appear to be poor prognostic markers for determining progression in patients receiving fulvestrant

  17. Report of transparency and nuclear safety 2007 CEA Fontenay aux Roses; Rapport transparence et securite nucleaire 2007 CEA Fontenay aux Roses

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Fontenay aux roses for the year 2007. After many years of decommissioning and dismantling of nuclear installations, the Center is now devoted (since 2005) to the development of research programmes on biology and biomedical technologies. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. (A.L.B.)

  18. Nuclear. In China, the CEA asserts itself as a team leader

    International Nuclear Information System (INIS)

    As the French government gave the CEA the responsibility of negotiating the nuclear French-Chinese nuclear strategic partnership, this article outlines the personality of the CEA's chairman, Bernard Bigot, but also the tensions which exist between the two main actors of the French nuclear industry, EDF and Areva, notably about their respective projects of development of a new reactor with China as far as EDF is concerned, and with Japan as far as Areva is concerned. In fact, China is asking France, not to build new reactors but to improve the performance and the safety in the existing ones

  19. Latest pixel size reduction of uncooled IR-FPA at CEA, LETI

    Science.gov (United States)

    Becker, Sebastien; Imperinetti, Pierre; Yon, Jean-Jacques; Ouvrier-Buffet, Jean-Louis; Goudon, Valérie; Hamelin, Antoine; Vialle, Claire; Arnaud, Agnès.

    2012-10-01

    Recent developments at the Infrared Lab (LIR) of CEA, LETI have been concentrated on the pixel size reduction of uncooled infrared detectors. With the support from French company ULIS, we have successfully demonstrated the technological integration of 12μm pixels on a commercial TV-format read-out circuit (VGA-ROIC) supplied by ULIS. The 12μm pixel has been designed, processed and characterized in CEA, LETI and first results showed exceptional performances. This paper presents the characterization and associated imagery results.

  20. The role of CA-242 and CEA in surveillance following curative resection for colorectal cancer.

    OpenAIRE

    Hall, N. R.; Finan, P. J.; Stephenson, B M; Purves, D. A.; Cooper, E H

    1994-01-01

    This study was undertaken to evaluate the role of a new tumour marker, CA-242, alone or in combination with CEA in the practical management of colorectal cancer patients after potentially curative resection. A cohort of 149 patients who had undergone 'curative' surgery was followed up according to an intensive protocol in order to detect recurrent disease. Over a median tumour marker follow-up period of 24 months there were 25 recurrences in 24 patients. Both CEA and CA-242 alone detected hal...

  1. The releases control and the environment survey of the Cea Centers

    International Nuclear Information System (INIS)

    The Cea sets the environment protection in the heart of its security policy, which is based on the mastership of risks resulting from the researches activities and installations development. This policy aims to reduce as small as possible compared with the technical and economical necessities, the impact of its activities on the human and the environment. This document, takes stock for the year 2002, of the liquid and gas radioactive effluents releases as also of the radioactivity level around the Cea Centers, by a systematic monitoring of the atmosphere, the waters, the vegetation and the milk. (A.L.B.)

  2. The CEA and the alternative energies. Press tour 25 and 26 november 1999

    International Nuclear Information System (INIS)

    In the framework of the public information on the CEA center of Cadarache and Grenoble, a presentation of the researches concerning the alternative energies is proposed. The Cea is commissioned by the Public Authorities, to keep the nuclear option open and for the long-dated, to develop renewable energies. In this domain researches on fuel cells and photovoltaic solar energy are performed. The principle and the applications of the fuel cell and the photovoltaic are recalled to introduce the research programs and the partners. (A.L.B.)

  3. 188Re-iorCEA1 as radioimmunotherapeutical agent: Preparation and evaluation. Cuba

    International Nuclear Information System (INIS)

    Effective immunotherapy of human malignancies requires the selective delivery of these agents to relevant antigen-expressing tumour cells. A variety of strategies have been investigated to achieve this objective. It has been very clearly established that ior-CEA1 monoclonal antibody is an extremely good agent for immunoscintigraphy with a high sensitivity (94%) and specificity (87%). Ior-CEA1 is hence a good candidate for development as a therapeutic agent. Moreover, it is an attractive novel protein, which conserves its biological properties, despite chemical treatment

  4. AMS/CEA Joint Aerial Campaign Nevada Test Site AMS Data Analysis Procedure

    International Nuclear Information System (INIS)

    The United States NNSA AMS (Aerial Measuring Systems) and the French Commissariat a l-Energie Atomique (CEA) participated in joint aerial survey activities during the period November 6-19, 2007. Survey activities were conducted near Las Vegas, Nevada, and at selected areas of the Nevada Test Site (NTS) under the auspices of the Accident Response Working Group (ARWG). The intent of the activities was to compare technologies, procedures, and data analysis techniques related to specific AMS and the CEA aerial radiation detection systems

  5. Changes in the legal status of the Commissariat a l'energie atomique (Cea)

    International Nuclear Information System (INIS)

    The Cea a public research institution was re-classified among the energy research establishments (11 december 2008). The Cea, as the result of exceptional circumstances and complex activities, is today entering into a new era and must confront many national and supranational challenges. It is preparing, in effect, for a future nuclear industry (safer, less polluting, non-proliferating and more economical) and is conducting research into other energy solutions within the framework of sustainable development and limited greenhouse gas effects (hydrogen technology, fusion, alternative energy technologies). It also has another goal, to make technological research available to industry, not only by developing micro and nano-technologies or even to contribute technology for the benefit of scientific knowledge of living creatures, matter, climate and the environment. The new classification of the Cea as a research establishment in the field of energy, a heading which includes three other entities (A.N.D.R.A., A.D.E.M.E. and I.F.P.), raises questions about its specialization and diversification. However, no substantive change was made to the drafting of the legislative provisions so it is possible to imagine that the Cea takes initiatives in other fields, at the instigation or with the approval of the government, a matter which is facilitated by its classification in the E.P.I.C. category (public establishment at industrial and commercial character). The Cea also represents France in international organisations in the nuclear sector, such as the OECD Nuclear energy agency (Nea), the International atomic energy agency (IAEA) and the European communities. It also participates in intergovernmental negotiations in the nuclear field and ensures any follow-up required with regard to any resulting agreements. today, the Cea plays a major role in the implementation of French nuclear policy with the aim of making available to countries wishing to develop nuclear energy, a framework

  6. Performances of Herschel/PACS bolometer arrays and future developments at CEA

    OpenAIRE

    Billot, N.; RODRIGUEZ, L.; Okumura, K; Sauvage, M.; Agnèse, P.

    2009-01-01

    The European Space Agency is building a space telescope to observe the Universe in the Far-IR and sub-millimeter regime of the electromagnetic spectrum. The scientific payload is composed of three instruments. One of them, PACS, is equipped with a novel type of bolometer arrays developed by CEA in the late 90's. We briefly present the PACS Photometer and the architecture of CEA filled bolometer arrays. We accessed the physics of the detectors and thoroughly measured their performances by deve...

  7. Assessment 2000 and regulation and method. Releases control and environmental survey of the CEA Centers; Bilan 2000 et reglementation et methode. Controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The environment quality around the CEA centers is a major interest of its safety policy. These documents contribute to the public information on the radioactive liquid and gaseous releases of the CEA, according to the ministry authorization. The radioactivity monitoring activity, and the survey methods are also presented. Data analysis from 1996 to 2000, allows to follow the evolution. (A.L.B.)

  8. Las Poáceas del Parque Nacional Yanachaga-Chemillén (Oxapampa, Perú. Parte II: Pooideae, Centothecoideae, Arundinoideae, Chloridoideae y Panicoideae

    Directory of Open Access Journals (Sweden)

    María I. La-Torre

    2013-06-01

    Full Text Available Se presenta la segunda parte de un estudio taxonómico de la Familia Poaceae del Parque Nacional Yanachaga-Chemillén y zonas aledañas (Oxapampa, Pasco, Perú. Se presentan 63 especies de Poáceas de las subfamilias Pooideae, Centothecoideae, Arundinoideae, Chloridoideae y Panicoideae, las cuales están incluidas en 37 géneros y 12 tribus. Se incluye una breve descripción de los géneros. Se ha elaborado claves para diferenciar los géneros y especies. Para cada especie se indica su ecología, distribución y el material estudiado.

  9. Elaboration of an alpha-numeric classification for file of matters of the documentation service of the CEA

    International Nuclear Information System (INIS)

    We give the principles of a classification of matters to square basis, suiting the needs of the Service, of Documentation of the C.E.A. We present the detail of the categories in the order of the 'columns', likewise the big scientific subdivisions at the CEA. (authors)

  10. Combined effects of protein kinase inhibitors and 5-fluorouracil on CEA expression in human colon cancer cells.

    Science.gov (United States)

    Prete, Salvatore Pasquale; Rossi, Lorena; Correale, Pier Paolo; Turriziani, Mario; Baier, Susanne; Tamburrelli, Giuliana; De Vecchis, Liana; Bonmassar, Enzo; Aquino, Angelo

    2005-08-01

    Previous studies showed that 5-fluorouracil (5-FU) and Staurosporine (ST), a protein kinase inhibitor (PKI), were able to increase the expression of carcinoembryonic antigen (CEA) in human colon cancer cells. In the present study, we examined the in vitro effects of five PKIs, i.e. ST, 1-5-isoquinolinyl-sulfonyl-2-methylpiperazine (H-7), bisindolylmaleimide-I (BIS), Genistein (GEN), and Herbimycin A (HERB) alone or in combination with 5-FU on CEA expression. C22-20, a clonal subline, derived from colon cancer HT-29 line, selected for low expression of CEA, was used in our experimental model. Among the PKIs tested, only ST, at non-toxic concentrations of 5 nM, was capable of increasing the level of CEA. The other PKIs did not modify CEA expression when used either alone or in combination with 5-FU. Flow cytometric analysis showed that treatment of cells with 5-FU + ST resulted in a synergistic increase of CEA expression, being higher than that obtainable with both agents alone. Moreover, the increase of CEA expression occurred not only in membrane fractions but also in cytosolic compartments, as indicated by Western blot analysis. The present study suggests that ST-mediated induction of CEA expression in cancer cells is PKC independent and could be of potential clinical interest for the development of new diagnostic and/or immunotherapeutic approaches. PMID:15967383

  11. Order of the 9. of March 2010 approving the decision no 2010-DC-0172 of the 5. of January 2010 by the Nuclear Safety Authority specifying the limits of releases in the environment of liquid and gaseous effluents of civil base nuclear installations of the Cadarache Centre operated by the Atomic Energy Commissariat (CEA) on the district of Saint-Paul-lez-Durance (Bouches-du-Rhone department); Arrete du 9 mars 2010 portant homologation de la decision no 2010-DC-0172 de l'Autorite de surete nucleaire du 5 janvier 2010 fixant les limites de rejets dans l'environnement des effluents liquides et gazeux des installations nucleaires de bases civiles du centre de Cadarache exploitees par le Commissariat a l'energie atomique (CEA) sur la commune de Saint-Paul-lez-Durance (departement des Bouches-du-Rhone)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This legal publication contains references to the different legal and official documents (codes, orders, minister's opinion, public surveys, administrative authorizations, local community opinion) at the root of this specification of limits related to releases in the environment of liquid and gaseous effluents of civil base nuclear installations of the Cadarache Centre operated by the Atomic Energy Commissariat (CEA) on the district of Saint-Paul-lez-Durance. These installations are listed and tables present the limits for different radioactive emissions (carbon 14, hydrogen 3, iodine, radioactive rare earths, and alpha, beta and gamma emitters) from these different installations, but also the maximum admitted concentrations for gaseous chemical effluents (HCl, HF, NOx, CO, and so on), as well as limits for thermal releases

  12. Clinical value of combined detection of serum CEA, CA15-3 and SF in lung cancer

    International Nuclear Information System (INIS)

    Objective: To investigate the clinical value of combined examination of serum CEA, CA15-3 and SF in lung cancer diagnosis. Methods: Serum concentrations of CEA, CA15-3 and SF were measured by chemiluminescent assay (CLA) in 99 patients with lung cancer and 25 patients with benign lung disease. Results: The positive rate of serum CEA, CA15-3 and SF in cases in lung cancer was 50.5%, 31.3% and 69.7%, respectively. Specificity of CEA, CA15-3 and SF measurements was 76%, 78% and 72%, respectively. In combined measurements, positive results of either two parameters revealed sensitivity and specificity of 82.8% and 92%, respectively. Conclusion: Combined measurements of CEA, CA15-3 and SF had evidently improved sensitivity and specificity in diagnosing lung cancer and thus were of good clinical value

  13. Combined determination of CEA, Fer, NSE and SCC levels in serum and chest effusion fluid for diagnosis of pulmonary cancer

    International Nuclear Information System (INIS)

    Objective: To study the clinical value of combined determination of CEA, Fer, NSE and SCC levels in serum and chest effusion fluid for dignosis of lung cancer. Methods: These four tumor markers were determined in serum and chest effusion fluid with RIA (NSE and SCC) or chemiluminescence method (CEA and Fer) in 52 patients with lung cancer, 48 patients with benign lung disease and 51 controls. Results: The serum and chest effusion fluid levels of CEA, Fer, NSE and SCC in patients with lung cancer were significantly higher than those in patients with benign lung diseases (all P<0.01) and 51 controls (P<0.001, <0.001, <0. 01 and <0.01 respectively). The positive rate of combined determination of CEA, Fer, NSE and SCC for lung cancer could be above 92.7%. Conclusion: Combined determination of CEA, Fer, NSE and SCC were a useful method for lung cancer diagnosis. (authors)

  14. Metastatic prostate cancer with elevated serum levels of CEA and CA19-9

    Directory of Open Access Journals (Sweden)

    Guang-Dar Juang

    2014-03-01

    Full Text Available Prostate-specific antigen (PSA is well known as a specific tumor marker for prostate cancer, but carcinoembryonic antigen (CEA- and carbohydrate antigen 19-9 (CA19-9-elevating adenocarcinomas originating in the prostate gland are rare. We report a case of metastatic adenocarcinoma of the prostate gland with a high serum level of CEA and CA19-9 in a 78-year-old man in whom prostate cancer (T3N1M1 had been diagnosed 2 years ago and who was treated with androgen deprivation therapy. He visited the emergency department because of a loss of appetite and abdominal pain. The serum CEA and CA19-9 levels were increased to 218.9 ng/mL (normal, <5 ng/mL and 212 ng/mL (normal, <27 ng/mL, respectively. The serum PSA level was slightly elevated (4.41 ng/mL. Computed tomography demonstrated multiple liver metastases, para-aortic lymph node enlargement, and lung metastases. A liver biopsy was performed and the specimen showed high-grade adenocarcinoma with focal positive staining for PSA. Despite chemotherapy with docetaxel, the patient died 3 months after treatment. Based on this case and a review of the literature, an aggressive variant of prostatic carcinoma with a high serum level of CEA and CA19-9 and a low PSA level was shown to progress rapidly with a poor prognosis.

  15. Solution recommended by the CEA to minimize fuel-cladding interaction problems

    International Nuclear Information System (INIS)

    To improve behavior of fuel elements under fast variation of power, the CEA developed a fracture resistant fuel: UO2 DCI and a cladding with low creep under irradiation: strong zircaloy 4. This paper gives main characteristics of these new materials and shows at what extent a better behavior of fuel pins is obtained concerning fuel-cladding interaction

  16. A study on the core analysis methodology for SMART CEA ejection accident-I

    International Nuclear Information System (INIS)

    A methodology to analyze the fuel enthalpy is developed based on MASTER that is a time dependent 3 dimensional core analysis code. Using the proposed methodology, SMART CEA ejection accident is analyzed. Moreover, radiation doses are estimated at the exclusion area boundary and low population zone to confirm the criteria for the accident. (Author). 31 refs., 13 tabs., 18 figs

  17. PZ Fiber Loss Measurements at LLNL and Plan to Confirm Results at CEA/Thomson

    CERN Document Server

    Bass, I L

    2000-01-01

    The objective of this paper is to confirm the slow-axis loss of less than 0.1 dB/m for the PZ fiber manufactured for LLNL by 3M and to provide samples of the fiber to CEA/Thomson that will permit them to readily verify this result.

  18. Situation 2002: release monitoring and surveillance of environment of Cea centers

    International Nuclear Information System (INIS)

    This publication renders an account of the situation of the releases of liquid and gaseous radioactive effluents, for the year 2002, as well as the radioactivity levels measured in the vicinity of Cea centers through the systematic surveillance of atmosphere, waters, vegetation and milk. An analysis on five years allows to follow their evolution. (N.C.)

  19. Plasma TIMP-1 and CEA as markers for detection of primary colorectal cancer

    DEFF Research Database (Denmark)

    Christensen, Ib Jarle; Brünner, Nils; Dowell, Barry;

    2015-01-01

    endoscopy were prospectively included (N=1965). Baseline data and co-morbidity were recorded. The primary end-point was the detection of CRC. Plasma was obtained before endoscopy and TIMP-1 and CEA levels were determined using an automated analysis platform when all samples were collected. RESULTS: CRC was...

  20. Experience gained at the CEA by thermal effluent utilization for agriculture and fish-breeding

    International Nuclear Information System (INIS)

    Results obtained at the CEA for waste heat utilization are examined. Water at T+100C is used for open air soil heating (forest, agriculture), eel breeding and greenhouse, heating (with the help of heat pumps). Water at T+230C or 300C is used for greenhouses. Facilities are described experience gained and results of the different exploitations are given

  1. Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas

    Science.gov (United States)

    Jogunoori, Wilma; Menon, Vipin; Majumdar, Avijit; Chen, Jiun-Sheng; Gi, Young Jin; Jeong, Yun Seong; Phan, Liem; Belkin, Mitchell; Gu, Shoujun; Kundra, Suchin; Mistry, Nipun A.; Zhang, Jianping; Su, Xiaoping; Li, Shulin; Lin, Sue-Hwa; Javle, Milind; McMurray, John S.; Rahlfs, Thomas F.; Mishra, Bibhuti; White, Jon; Rashid, Asif; Beauchemin, Nicole; Weston, Brian R.; Shafi, Mehnaz A.; Stroehlein, John R.; Davila, Marta; Akbani, Rehan; Weinstein, John N.; Wu, Xifeng; Mishra, Lopa

    2016-01-01

    Mutational processes and signatures that drive early tumorigenesis are centrally important for early cancer prevention. Yet, to date, biomarkers and risk factors for polyps (adenomas) that inordinately and rapidly develop into colon cancer remain poorly defined. Here, we describe surprisingly high mutational profiles through whole-genome sequence (WGS) analysis in 2 of 4 pairs of benign colorectal adenoma tissue samples. Unsupervised hierarchical clustered transcriptomic analysis of a further 7 pairs of adenomas reveals distinct mutational signatures regardless of adenoma size. Transitional single nucleotide substitutions of C:G>T:A predominate in the adenoma mutational spectrum. Strikingly, we observe mutations in the TGF-β pathway and CEA-associated genes in 4 out of 11 adenomas, overlapping with the Wnt pathway. Immunohistochemical labeling reveals a nearly 5-fold increase in CEA levels in 23% of adenoma samples with a concomitant loss of TGF-β signaling. We also define a functional role by which the CEA B3 domain interacts with TGFBR1, potentially inactivating the tumor suppressor function of TGF-β signaling. Our study uncovers diverse mutational processes underlying the transition from early adenoma to cancer. This has broad implications for biomarker-driven targeting of CEA/TGF-β in high-risk adenomas and may lead to early detection of aggressive adenoma to CRC progression. PMID:27100181

  2. The study of special killing effect of CD3AK on anti-CEA-positive tumor enhanced by DC loaded with CEA-rV%荷CEA-rV的DC增强CD3AK对CEA阳性肿瘤特异性杀伤作用的研究

    Institute of Scientific and Technical Information of China (English)

    祁岩超; 王新帅; 扬波

    2006-01-01

    Objective: To survey the special killing activity of CD3AK on anti-CEA-positive tumor enhanced by umbilical cord blood dendritic cell (DC) loaded with CEA recombinant vaccinia virus (CEA-rV). Methods: Freshly isolated umbilical blood mononuclear cells (UBMC) were cultivated for 3 h. Suspension cells and attached cells were used to induce CD3AK cells and DC separately. DC was loaded with CEA-rV on the 3rd day to prepare CEA-rV+DC. CD3AK cells were co-cultured with CEA-rV+DC on the 8th day, to prepare CEA-rV+DC+CD3AK. The killing activity of each effector's cell, which included UBMC, CD3AK, DC+CD3AK and CEA-rV+DC+CD3AK, was measured respectively by MTT reduction assay. Results: (1) 4 target cells were confirmed by CEA monoclonal antibody of rabbit anti-human. Lovo and A549 were really CEA positive cell lines, while Bel-7402 and K562 were CEA negative cell lines. (2) It was showed by flow-cytometry that the mature DC cultured at 10th day expressed MHCⅠ, Ⅱ molecules such as CD86, CD80, CD83 and CD40 highly, but CD123 lowly. The expression rates of CD86, CD80, CD83 and CD40 was 82.7%, 51.1%, 57.5% and 69.4%, respectively. The appearances and intra-cellular structures of DC were observed through light and electron microscope. The diameter of mature DC was 15-20 μm presented the irregular morphologic appearance, much prominences and pseudopodium. There were abundant mitochondria and endoplasmic reticulum in DC endochylema. (3) The rates of CD3, CD4, CD8 and CD28 in CD3AK cells group were 2 folds higher than that in UBMC group by FACS.It was said that the numbers of the mature T lymphocyte in CD3AK cells group were much greater than that in UBMC group. (4)The killing activities to 4 target cells of 3 effector's cells, which included CEA-rV+DC+CD3AK, DC+CD3AK and CD3AK, were much greater than that of UBMC (P<0.01). Moreover, comparing with the killing activities of 4 effector's: CEA-rV+DC+CD3AK group > DC+CD3AK group > CD3AK group > UBMC group. It showed that

  3. Dispersion of Radionuclides and Exposure Assessment in Urban Environments: A Joint CEA and LLNL Report

    Energy Technology Data Exchange (ETDEWEB)

    Glascoe, Lee [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gowardhan, Akshay [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lennox, Kristin [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Simpson, Matthew [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Yu, Kristen [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Armand, Patrick [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Duchenne, Christophe [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Mariotte, Frederic [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Pectorin, Xavier [Alternative Energies and Atomic Energy Commission (CEA), Paris (France)

    2014-12-19

    In the interest of promoting the international exchange of technical expertise, the US Department of Energy’s Office of Emergency Operations (NA-40) and the French Commissariat à l'Energie Atomique et aux énergies alternatives (CEA) requested that the National Atmospheric Release Advisory Center (NARAC) of Lawrence Livermore National Laboratory (LLNL) in Livermore, California host a joint table top exercise with experts in emergency management and atmospheric transport modeling. In this table top exercise, LLNL and CEA compared each other’s flow and dispersion models. The goal of the comparison is to facilitate the exchange of knowledge, capabilities, and practices, and to demonstrate the utility of modeling dispersal at different levels of computational fidelity. Two modeling approaches were examined, a regional scale modeling approach, appropriate for simple terrain and/or very large releases, and an urban scale modeling approach, appropriate for small releases in a city environment. This report is a summary of LLNL and CEA modeling efforts from this exercise. Two different types of LLNL and CEA models were employed in the analysis: urban-scale models (Aeolus CFD at LLNL/NARAC and Parallel- Micro-SWIFT-SPRAY, PMSS, at CEA) for analysis of a 5,000 Ci radiological release and Lagrangian Particle Dispersion Models (LODI at LLNL/NARAC and PSPRAY at CEA) for analysis of a much larger (500,000 Ci) regional radiological release. Two densely-populated urban locations were chosen: Chicago with its high-rise skyline and gridded street network and Paris with its more consistent, lower building height and complex unaligned street network. Each location was considered under early summer daytime and nighttime conditions. Different levels of fidelity were chosen for each scale: (1) lower fidelity mass-consistent diagnostic, intermediate fidelity Navier-Stokes RANS models, and higher fidelity Navier-Stokes LES for urban-scale analysis, and (2) lower-fidelity single

  4. Project: Decommissioning and Reuse of Licensed Nuclear Facilities at the CEA Centre, Fontenay-aux-Roses, (CEA-FAR) France. Annex A.I-3

    International Nuclear Information System (INIS)

    CEA-FAR is the CEA's oldest facility and is situated in the southern suburbs of Paris. It was opened on 26 March 1946 to host the first French atomic pile, which was named ZOE, and first went critical on 12 December 1946. The first laboratories were installed in existing buildings on the site. In the early 1950s, a number of nuclear facilities to be used for R and D work were built within the perimeter of the centre. This included the construction and operation of a pilot plant facility for the reprocessing of spent nuclear fuel. As space was restricted, all these installations were decommissioned and demolished to enable the construction of more modern second generation facilities. The Pu Pilot Plant for irradiated fuel reprocessing (the prototype of the Marcoule UP1 Plant) was used from 1953 to 1958. The dismantling of the equipment from the Pu Pilot Plant, the demolition of the buildings and the removal of the grounds to constitute a uniform platform were completed at the end of the 1950s. This operation made it possible to release the grounds on which building 18 was built, and also buildings 91 and 52. These buildings were constructed during the 1960s within the framework of the development of the CEN-FAR programmes. In the late 1950s and early 1960s, in addition to ZOE (NLF 11), which remained in service, the following second generation facilities were built: radio-metallurgy installations (NLF 58 and 59), radiochemistry and chemical engineering installations for the reprocessing of spent fuel (NLF 57), and installations for the treatment and interim storage of solid and liquid waste (NLF 34 and 73), which were required for pursuing the research programmes. These latter buildings are currently being cleaned up and dismantled. ZOE was closed down and partly dismantled in the 1970s to former IAEA Stage 2 and the research areas around the pile were transformed into a museum. The facilities shut down and dismantled in the 1980s were plutonium metallurgy

  5. Progress of the BT-EdF-CEA project. The lithium polymer battery; Avancees du projet BT-EdF-CEA. Batterie lithium polymere

    Energy Technology Data Exchange (ETDEWEB)

    Marginedes, D.; Majastre, H. [Bollore Technologies, 29 - Quimper (France); Baudry, P.; Lascaud, S. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches; Bloch, D.; Lebrun, N. [CEA Grenoble, CEREM, 38 (France)

    1996-12-31

    The lithium-polymer energy storage technology requires the production of thin films of huge surface. The BT-EdF-CEA consortium has studied the various manufacturing techniques of these films and their assembly. The process was chosen according to its productivity, low expensiveness, ecological impact and energy performances with capacities reaching 40 Ah. This paper explains: the objectives and specifications of the project, the advantage of the consortium and the role of the different partners, the results (coating, dry extrusion and battery element manufacturing techniques), and the electrochemical performances of the elements. (J.S.)

  6. Producing energy without greenhouse effect gases: the CEA action; Produire de l'energie sans gaz a effet de serre: l'action du CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    Major actor in the domain of new energy technologies, the CEA manages the french research on the hydrogen and the fuel cells. It is also implied with INES (National Institute for the Solar Energy) in the photovoltaic and thermal solar. With the IFP (French Petroleum Institute), it manages research on biofuels. Of course the thermonuclear fusion, for the development of the energy of the future, is in its research program too. This information document presents the possibilities of these energies and the associated research programs. (A.L.B.)

  7. Hookah smoking and cancer: carcinoembryonic antigen (CEA levels in exclusive/ever hookah smokers

    Directory of Open Access Journals (Sweden)

    Chaouachi Kamal

    2008-05-01

    Full Text Available Abstract Background We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (cigarettes, bidis, etc.. Objectives To find serum CEA levels in ever/exclusive hookah smokers, i.e. those who smoked only hookah (no cigarettes, bidis, etc., prepared between 1 and 4 times a day with a quantity of up to 120 g of a tobacco-molasses mixture each (i.e. the tobacco weight equivalent of up to 60 cigarettes of 1 g each and consumed in 1 to 8 sessions. Methods Enhanced chemiluminescent immunometric technique was applied to measure CEA levels in serum samples from 59 exclusive male smokers with age ranging from 20–80 years (mean = 58.8 ± 14.7 years and 8–65 years of smoking (mean = 37.7 ± 16.8. 36 non-smokers served as controls. Subjects were divided into 3 groups according to the number of preparations; the number of sessions and the total daily smoking time: Light (1; 1; ≤ 20 minutes; Medium (1–3; 1–3; >20 min to ≤ 2 hrs and Heavy smokers (2–4; 3–8; >2 hrs to ≤ 6 hrs. Because of the nature of distribution of CEA levels among our individuals, Wilcoxon's rank sum two-sample test was applied to compare the variables. Results The overall CEA levels in exclusive hookah smokers (mean: 3.58 ± 2.61 ng/ml; n = 59 were not significantly different (p ≤ 0.0937 from the levels in non-smokers (2.35 ± 0.71 ng/ml. Mean levels in light, medium and heavy smokers were: 1.06 ± 0.492 ng/ml (n = 5; 2.52 ± 1.15 ng/ml (n = 28 and 5.11 ± 3.08 ng/ml (n = 26 respectively. The levels in medium smokers and non-smokers were also not significantly different (p ≤ 0.9138. In heavy smokers, the CEA levels were significantly higher than in non-smokers (p ≤ 0.0001567. Conclusion Overall CEA levels in exclusive hookah

  8. CEA serum level as early predictive marker of outcome during EGFR-TKI therapy in advanced NSCLC patients.

    Science.gov (United States)

    Facchinetti, Francesco; Aldigeri, Raffaella; Aloe, Rosalia; Bortesi, Beatrice; Ardizzoni, Andrea; Tiseo, Marcello

    2015-08-01

    Considering the role of carcinoembryonic antigen (CEA) serum levels as potential useful predictive marker during chemotherapy treatment, we studied its applicability in advanced non-small cell lung cancer (NSCLC) patients treated with epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs). Our retrospective cohort consists of 79 patients (33 EGFR mutated and 46 EGFR wild type or unknown) affected by advanced NSCLC, for whom CEA serum values at the beginning of TKI therapy and after the first month of treatment were available, regardless of treatment line. Baseline CEA value, percentage of CEA reduction after 1 month, and percentage of patients with ≥20 % CEA decrease after 1 month (CEA response) were correlated with disease control rate (DCR), progression-free (PFS), and overall (OS) survival, according to EGFR mutational status. Median baseline CEA levels were significantly higher in EGFR mutated (40.9 ng/ml; interquartile range (IQR) 8.9-197.6) than in wild-type cases (6.2 ng/ml; IQR 2.8-12.8; p = 0.003). Both percentage reduction in CEA levels (-10.7 vs. +13.4 %) and percentage of cases with CEA response (42 vs. 20 %) were significantly higher in mutated vs. wild-type/unknown patients (p = 0.007 and p = 0.027, respectively). In wild-type/unknown patients, CEA response was significantly correlated with DCR (p = 0.001) and resulted as a significant predictor of PFS both in univariate (p = 0.002) and in multivariate analyses (hazard ratio (HR) 0.27; 95 % confidence interval (CI) 0.11-0.66; p = 0.004); only a trend was found for OS prediction (p = 0.082). In EGFR-mutated group, CEA reduction did not show any correlation either with PFS or OS. CEA response after 1 month of EGFR-TKI therapy could be a useful marker, worthy to further studies, as early predictor of treatment outcome in EGFR wild-type/unknown unselected NSCLC cases for which no molecular predictor is yet available. PMID:25731731

  9. Protein expression levels of carcinoembryonic antigen (CEA) in Danish ovarian cancer patients: from the Danish 'MALOVA'ovarian cancer study

    DEFF Research Database (Denmark)

    Hogdall, E.V.; Christensen, L.; Blaakaer, J.; Jarle, Christensen,I; Gayther, S.; Jacobs, I.J.; Hogdall, C.K.; Kjær, Susanne Krüger

    2008-01-01

    from 189 women diagnosed with low malignant potential ovarian tumours (LMP, borderline ovarian tumours) and 571 women diagnosed with ovarian cancer (OC). RESULTS: Using 30% as the cut-off level for CEA over-expression, 18% of LMPs and 4% of OCs were positive. A higher proportion of mucinous tumours......AIMS: To determine the variation in expression of carcinoembryonic antigen (CEA) in 760 epithelial ovarian tumours from Denmark, and to correlate expression with clinicopathological parameters and prognosis for the disease. METHODS: Using tissue arrays (TA), we analysed CEA expression in tissues...

  10. Selección de rizobacterias por su antagonismo frente a microorganismos patógenos de cucurbitáceas /Screening of rhizobacteria for their antagonism against microbial pathogens of cucurbits.

    Directory of Open Access Journals (Sweden)

    Gilda Jiménez Montejo

    2014-04-01

    Full Text Available Resumen:El desarrollo de inoculantes microbianos a partir de aislamientos de rizobacterias con potencial para el control biológico de enfermedades de los cultivos agrícolas requiere de una rigurosa selección. Se obtuvieron aislamientos bacterianos de la rizosfera de papa (Solanum tuberosum L. y de maíz (Zea mays L. y de semillas de frijol (Phaseolus vulgaris L.. Las colonias que mostraron in vitro halos de inhibición de los patógenos de cucurbitáceas: Xanthomonas cucurbitae, Acidovorax avenae subsp. citrull y Fusarium oxysporum, se seleccionaron como antagonistas. A partir de las características morfológicas, fisiológicas y bioquímicas las cepas antagonistas F16/95 y Xph se identificaron con la especie Bacillus subtilis y la cepa 14A como Pseudomonas putida. Las pruebas presuntivas de producción de antibiocinas in vitro sugirieron modos de acción de las rizobacterias relacionados con antibiosis y competencia por el hierro mediante la producción de sideróforos. Los resultados indicaron el potencial de las cepas de rizobacterias antagonistas Bacillus subtilis (F16/95, Xph y Pesudomonas putida 14A para el control biológico de enfermedades de las cucurbitáceas./Abstract:

  11. Fusion technology. Annual report of the Association CEA/EURATOM 1997

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le Vagueres, F

    1998-12-31

    The research and development work performed by the French EURATOM-CEA Association for fusion technology is part of the Fusion Programme of the European Community. This report compiles the work carried out during the year 1997 as follows: The ITER CEA activities and related developments are described in the first section (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); The second part is dedicated to the Long Term activities as Blankets and material developments, long term safety, socio-economic problem; The Underlying Technology activities are compiled in the third part of this report (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); And the fourth part describes the inertial confinement studies. (K.A.)

  12. Diatomácea marinha Coscinodiscus wailesii Gran et Angst(BACILLARIOPHYCEAE)

    OpenAIRE

    Ascencio, Poliana G. Marson

    2012-01-01

    A diatomácea marinha cêntrica Coscinodiscus wailesii Gran et Angst, considerada uma espécie nociva, vem despertando grande interesse ecológico. Suas florações, vêm prejudicando áreas de pesca e cultivo em diferentes regiões do mundo. Entretanto essa microalga marinha é muito pouco estudada em relação ao seu crescimento celular, composição química, produção e caracterização de polissacarídeos e ácidos graxos. Sendo assim, nesse trabalho foi realizado o isolamento e o cultivo da diatomácea C. w...

  13. The French 'CEA 86' multigroup cross-section library and its integral qualification

    International Nuclear Information System (INIS)

    This paper describe the up-dated 99 groups library of the APOLLO French neutron computer code, the denominated 'CEA 86' library. The multigroup cross-section sets are based on the more recent nuclear data evaluations. The THEMIS code was generally used for the JEF-1 processing. In order to account for recent differential measurements and to improve the consistency between calculation and integral experiments, we produced our own CEA evaluations for the actinide nuclides: 235U, 238U, 239Pu, 240Pu, 241Am. This new APOLLO library was checked against critical experiments and PWR measurements: computed Conversion Factor, Reactivity Coefficients, Multiplication Factor, and Pu build-up are now in good agreement with LWR experimental results. PWR Pu recycling calculations, as does as HCLWR design studies, are also significantly improved. (author)

  14. 2004 annual report. Defense, safety, energy, information, health. CEA in the center of big European challenges

    International Nuclear Information System (INIS)

    This document is the 2004 annual report of the French atomic energy commission (CEA). It presents the R and D activities of the CEA in three main domains: 1 - defense and safety, maintaining perenniality of nuclear dissuasion and nuclear safety: supplying nuclear weapons to armies, maintaining dissuasion capability with the simulation program, sharing R and D means with the scientific community and the industrial world, designing and maintaining naval nuclear propulsion reactors, cleansing Marcoule and Pierrelatte facilities, monitoring treaties and fighting against proliferation and terrorism; 2 - energy, developing more competitive and cleaner energy sources: nuclear waste management, optimization of industrial nuclear activities, future nuclear systems and new energy technologies, basic research on energy, radiobiology and toxicology; 3 - information and health, valorizing industry thanks to technological research and supplying new tools for health and medical research: micro- and nano-technologies, software technologies, basic research for industrial innovation, nuclear technologies for health and bio-technologies. (J.S.)

  15. Cancer mortality of nuclear workers of CEA and COGEMA from 1969 to 1986

    International Nuclear Information System (INIS)

    Cancer mortality of the nuclear workers of CEA and COGEMA has been collected by the occupational health services of both firms from 1969 to 1986. The data are related only to the workers who died when in activity. Only very few workers left CEA and COGEMA before retirement so we consider this mortality survey as describing correctly the cancer mortality for the age groups less than 60-65 years old. Compared to the national mortality of same sex, age and calendar period, by the method of indirect standardization, the only excess observed was in the female population, linked to breast cancer mortality. The male population demonstrated a high healthy worker effect, even for cancer mortality. This study has now to be completed by an typical epidemiological cohort study in order to test cancer mortality after retirement and to discuss a possible relation with occupational exposure. (author)

  16. The role of the CEA in the first steps of neutronics

    International Nuclear Information System (INIS)

    A historical review of the early developments of neutronics and nuclear energy experimentations in France since World War II, with the creation of the CEA in 1945: neutronics theory investigations through the works of some leading french physicists, giving rise to the calculations of the first French heavy water reactor Zoe and its numerous experimentations, the theoretical works on mathematical physics in the fifties and sixties: spherical harmonics decompositions, double spherical harmonics method, calculations of the effect of cavities and cooling ducts on diffusion coefficient and reactivity, the development of models for phenomenon description. The various ways of knowledge and information dissemination involving the CEA at that time are presented, leading to the creation in 1956 of the INSTN nuclear techniques and sciences institute

  17. R and D developments on the disposal of radioactive wastes recently carried out at CEA (France)

    International Nuclear Information System (INIS)

    Since the law of december 31, 1991 voted by the French Parliament, disposal in geological formations is not the sole option considered for the management of radioactive wastes. Scientists and engineers, notably within the 'Commissariat a l'Energie Atomique' (CEA), must investigate in parallel two other options, namely i. advanced separation of long-lived radioisotopes and transmutation, and ii. improvement of radioactive waste matrices and long-term storage. Still, the geological disposal of radioactive wastes, which has generated within the last decade an immense amount of Research and Development, remains a major proposed solution to the long-term management of transuranic and high-level wastes. In this paper, we will describe some of the Research and Development carried out within CEA, avoiding the industrial and engineering aspects of the issues dealt with. Rather, we will illustrate major points of our basic research, underlining in particular methodological considerations

  18. Technetium-99m labelling of the IOR CEA 1 monoclonal antibody: evaluation of different methods

    Energy Technology Data Exchange (ETDEWEB)

    Gano, L.; Fernandes, C.; Patricio, L. [Inst. Tecnologico Nuclear, Sacavem (Portugal); Cantinho, G.; Santos, A.I.; Pena, H. [F.M.L., Lisboa (Portugal). Inst. Medicina Nuclear; Vieira, R.; Salgado, L. [IPOFG, Lisboa (Portugal). Servico Medicina Nuclear

    1997-09-01

    Aim: The aim of this study was to investigate the in vivo and in vitro properties of {sup 99m}Tc labelled monoclonal antibody, IOR CEA 1 when radiolabelled by different methods. Methods: To achieve that purpose IOR CEA was directly radiolabelled via 2-mercaptoethanol (2-Me) and stannous ion (SnCl{sub 2}) reduction and indirectly via the 2-iminothiolane (2-Im) conjugation. The resulting {sup 99m}Tc-MoAbs were analysed for number of free sulfhydryl groups, chemical and radiochemical purity (checked by HPLC and SDS PAGE), immunoreactivity and biological distribution in mice. Results: Experimental results indicated a similar radiochemical purity and immunoreactivity for direct labelling methods and a decrease of both for 2-Im method. 2-Me antibody reduction led to a high antibody fragmentation as indicated by non-denaturing SDS PAGE analysis. Nevertheless SnCl{sub 2} and 2-Im labels revealed lower in vivo stability. Conclusion: {sup 99m}Tc-(2-Me) IOR CEA presented favourable in vitro and in vivo properties. Therefore this label was compared to {sup 99m}Tc-monoclonal antibody BW 431/26. Similar characteristics were found. Clinical studies also revealed identical biodistribution profile. (orig.) [Deutsch] Ziel: Ziel der vorliegenden Studie war die Untersuchung der in vitro und in vivo Eigenschaften Technetium-markierter monoklonaler Antikoerper. Methoden: Hierzu wurde IOR CEA 1 entweder direkt, nach Reduktion mit 2-Mercaptoethanol (2-Me) bzw. Zinn(II)chlorid (SnCl{sub 2}), oder indirekt nach Konjugation mit 2-Iminothiolan (2-Im) markiert. Die Integritaet des reduzierten bzw. konjugierten Antikoerpers wurde mittels Bindungsassays und Elektrophorese ermittelt. Die radiochemischen Ausbeuten bzw. Reinheiten wurden chromatographisch bestimmt. Die pharmakokinetischen Eigenschaften von {sup 99m}Tc-IOR CEA 1 wurden tierexperimentell im Vergleich zu {sup 99m}Tc-BW 431/26 ermittelt. In einer ersten Studie wurden {sup 99m}Tc-(2-Me-)IOR CEA 1 und {sup 99m}Tc-BW 431/26 verglichen

  19. Corium behaviour research at CEA Cadarache. The PLINIUS prototypic corium experimental platform

    International Nuclear Information System (INIS)

    In the hypothetical case of a Light Water Reactor severe accident, the reactor core could melt and form with structure materials, and eventually concrete, a complex mixture called corium. The knowledge of corium behaviour is one of the key to increase the safety of the nuclear reactors. In the framework of severe accident studies, CEA has undertaken for many years a large RandD program devoted to this topic. At CEA-Cadarache, a specific platform, called PLINIUS, has been developed and is dedicated to studies of prototypic corium (i.e. with uranium dioxide). In this paper, the PLINIUS platform four facilities and the experiments on corium behaviour are described.(author)

  20. Fusion technology. Annual report of the Association CEA/EURATOM 1997

    International Nuclear Information System (INIS)

    The research and development work performed by the French EURATOM-CEA Association for fusion technology is part of the Fusion Programme of the European Community. This report compiles the work carried out during the year 1997 as follows: The ITER CEA activities and related developments are described in the first section (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); The second part is dedicated to the Long Term activities as Blankets and material developments, long term safety, socio-economic problem; The Underlying Technology activities are compiled in the third part of this report (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); And the fourth part describes the inertial confinement studies. (K.A.)

  1. Report of transparency and nuclear safety 2007 CEA Fontenay aux Roses

    International Nuclear Information System (INIS)

    This report presents the activities of the CEA Center of Fontenay aux roses for the year 2007. After many years of decommissioning and dismantling of nuclear installations, the Center is now devoted (since 2005) to the development of research programmes on biology and biomedical technologies. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. (A.L.B.)

  2. EURATOM-CEA association contributions to the 21st symposium on fusion technology

    International Nuclear Information System (INIS)

    The 27 contributions of EURATOM-Cea association have been gathered with 6 additional papers and 1 invited paper in this document. Most papers concern Tore-Supra and deal with the ergodic divertor, particle injection, impedance concept for ICRF antennas, low hybrid current drive, RF systems, the 118 GHz ECRH experiment, the inner first wall, improved vacuum vessel protection, pellet injection, material activation, and the CIEL project. 3 of the additional papers concern the model coil of ITER

  3. Integral experiments performed at CEA to improve the Pu higher isotope nuclear data: PLUTO programme

    International Nuclear Information System (INIS)

    The characteristics and main results of the experimental program PLUTO, developed at CEA to improve the Pu higher isotope nuclear data, are presented. The integral experiments performed aim at providing the information necessary to adjust the multigroup cross sections used for the design calculations. The comparison of the calculation to experiment deviations on the integral parameters before and after the cross-section adjustment show the improvement brought by the PLUTO program. 6 figures, 10 tables

  4. Differentialdiagnose beim Lungenkarzinom durch CEA, CYFRA 21-1, NSE und ProGRP

    OpenAIRE

    Gruber, Christine

    2008-01-01

    Es handelt sich um eine bizentrische, retrospektive Studie am Institut für Klinische Chemie am Klinikum Großhadern, München und an der Asklepioslungenfachklinik Gauting. Anhand von insgesamt 2749 Patienten wurde univariat und multivariat analysiert, inwieweit die Tumormarker CEA, CYFRA 21-1, NSE und ProGRP und zusätzlich die Routinelaborparameter eine Hilfestellung sowohl in der Diagnostik und Differentialdiagnostik eines Lungenrundherdes (benigne Lungenerkrankung, primäres Lungenkarzinom, Lu...

  5. Evaluation 2000 and regulation and method. Release monitoring and environmental surveillance around Cea centers

    International Nuclear Information System (INIS)

    This publication counts for the year 2000 for the evaluation of liquid and gaseous radioactive effluents releases and the radioactivity levels measured in the vicinity of Cea centers, through the air, water, vegetation and milk surveillance. An analysis of the results from 1996 to 2000 allows to follow their evolution. A second booklet develops the sampling and measurement methods made on effluents in environment. It present besides the regulation applied to effluents monitoring. (N.C.)

  6. EURATOM-CEA association contributions to the 21st symposium on fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Garin, P.; Grosman, A.; Beaumont, B. [and others

    2000-11-01

    The 27 contributions of EURATOM-Cea association have been gathered with 6 additional papers and 1 invited paper in this document. Most papers concern Tore-Supra and deal with the ergodic divertor, particle injection, impedance concept for ICRF antennas, low hybrid current drive, RF systems, the 118 GHz ECRH experiment, the inner first wall, improved vacuum vessel protection, pellet injection, material activation, and the CIEL project. 3 of the additional papers concern the model coil of ITER.

  7. Insights into the economic viability of a new CEA system producing hydroponic lettuce

    OpenAIRE

    Ilaslan, Gunes; White, Gerald B.; Langhans, Robert W.

    2002-01-01

    A new CEA (Controlled Environment Agriculture) system growing Boston lettuce, Lactuca Sativa cv. ‘Vivaldi’, achieves the same quality and quantity of production every day of the year. The year-round constant quantity and quality production indicate potential for success. However, our research showed that out of nine selected U.S. locations with different climatic and economic conditions, the Northeast had 25.7 percent higher production costs for the same yield. The analysis indicated that giv...

  8. Aeroacoustics research in Europe: The CEAS-ASC report on 2013 highlights

    Science.gov (United States)

    Bennett, G. J.; Kennedy, J.; Meskell, C.; Carley, M.; Jordan, P.; Rice, H.

    2015-03-01

    The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, "aeroacoustics" encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe. This paper is a report on highlights of aeroacoustics research in Europe in 2013, compiled from information provided to the ASC of the CEAS. During 2013, a number of research programmes involving aeroacoustics were funded by the European Commission. Some of the highlights from these programmes are summarised in this paper, as well as highlights from other programmes funded by national programmes or by industry. Furthermore, a concise summary of the CEAS-ASC workshop "Atmospheric and Ground Effects on Aircraft Noise" held in Seville, Spain in September 2013 is included in this report. Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection. This issue of the "highlights" paper is dedicated to the memory of Prof. John A. Fitzpatrick, Professor of Mechanical Engineering, Trinity College Dublin, and a valued member of the Aeroacoustics Specialists Committee. John passed away in September 2012 and is fondly missed across the globe by the friends he made in the Aeroacoustics Community. This paper is edited by PhD graduates and colleagues of John's who conduct research in aeroacoustics, inspired by his thirst for knowledge.

  9. Cea strategy in the field of simulation and high-performance computing

    International Nuclear Information System (INIS)

    The full text of the publication follows. Modelling and Simulation are at the heart of research and development activities carried out by Cea. Modelling relies not only on the most advanced theories and on phenomenological experiments that ensured their tuning, but also on more instrumented experiments that deliver both the useful data for the implementation of these models and the elements required for their validation. Simulation not only covers an as close as possible representation of the physical reality, but more generally all numerical experimentation carried out with any model. In particular, there are scientific problems that cannot be solved by simulation alone. Cea makes use of simulation for understanding, for design, and for taking actions. Particle physics, climatology, the analysis and comparison of genomic sequences, the study of dynamics and folding of proteins, material physics or high temperature plasma physics illustrate the theme of simulation 'for understanding'. Designing fission or fusion reactors of the future, or nuclear weapons may use of simulation for design. Real-time simulators that aim at training operators of nuclear power plants, as well as simulations carried out to prove nuclear safety, belong to the third category. Technological evolution in the field of computers, software, or algorithms, or more generally progress made in the field of modelling have enabled Cea and others to advance significantly in regard to simulation. The hierarchization of models and multi-scale simulation techniques permit in fact the use of results stemming from milli-metric, micro-metric or even nano-metric level simulations for models that are representative of the system at the metric level. The same is true for time-scales. The rendering common place of workstations or PC-cluster based department servers, readily offering a performance of the order of a Giga-flop or tens of Giga-flops, makes it possible to meet the large majority of Cea needs. The

  10. Technetium-99m labelling of the IOR CEA 1 monoclonal antibody: evaluation of different methods

    International Nuclear Information System (INIS)

    Aim: The aim of this study was to investigate the in vivo and in vitro properties of 99mTc labelled monoclonal antibody, IOR CEA 1 when radiolabelled by different methods. Methods: To achieve that purpose IOR CEA was directly radiolabelled via 2-mercaptoethanol (2-Me) and stannous ion (SnCl2) reduction and indirectly via the 2-iminothiolane (2-Im) conjugation. The resulting 99mTc-MoAbs were analysed for number of free sulfhydryl groups, chemical and radiochemical purity (checked by HPLC and SDS PAGE), immunoreactivity and biological distribution in mice. Results: Experimental results indicated a similar radiochemical purity and immunoreactivity for direct labelling methods and a decrease of both for 2-Im method. 2-Me antibody reduction led to a high antibody fragmentation as indicated by non-denaturing SDS PAGE analysis. Nevertheless SnCl2 and 2-Im labels revealed lower in vivo stability. Conclusion: 99mTc-(2-Me) IOR CEA presented favourable in vitro and in vivo properties. Therefore this label was compared to 99mTc-monoclonal antibody BW 431/26. Similar characteristics were found. Clinical studies also revealed identical biodistribution profile. (orig.)

  11. Radioimmunoimaging of ovarian cancer with 131I labelled CEA monoclonal antibody

    International Nuclear Information System (INIS)

    Objective: To investigate radioimmunoimaging with 131I labelled CEA McAb and its value in diagnosis and treatment of ovarian cancer. Methods: CEA McAb was labelled with 131I by standard chloramine T procedure. The radiolabeled McAb was given intravenously to the patients. The scintigraphy was performed at different time. Results: In 105 patients with histopathology proved ovarian cancers, for 96 patients the lesions were well located with RII (true positives), for the remaining 9 patients, the results were false negative. 22/23 cases with RII diagnosed benign ovarian tumors were proved to be true negative by surgical pathology in RII. Of 96 ovarian cancers 87 were stratified into identical stages by surgical pathology all RII. 141/151 metastatic tumors were found in RII and the positive rate was as high as 93.4%. The smallest tumor defected by RII was of 1 cm in diameter. Conclusions: RII is as good as ultrasonography and CT in distinguishing benignancy and malignancy. The location, size and number of the lesions can also be determined with RII. RII of ovarian cancer with 131I-CEA McAb is valuable and helpful in early detection of ovarian cancer. It is also helpful for clinical staging, treatment programing and prognosticating

  12. Annual report of the Association EURATOM-Cea 2005 (full report)

    International Nuclear Information System (INIS)

    This annual report summarizes activities performed by the EURATOM-Cea association in 2005. The activities carried out in the field 'physics integration' are mainly linked to the ion cyclotron range of frequency antenna development and to the development of diagnostic components. The vacuum vessel studies have mainly focused at welding techniques and at qualification of inspection methods along the vacuum vessel inter-sector weld. On the plasma facing component side investigations have been performed on material knowledge (CuCrZr creep-fatigue studies, neutron effects on material properties of CFC, development and optimisation of Be/CuCrZr joining techniques and studies dedicated to the divertor. In the field 'magnets', EURATOM-Cea association has devoted a major part of its effort to the studies of advanced Nb3Sn strands for the toroidal field coil, and the first full size conductor sample was manufactured. Within the frame of Test Blanket Module (TBM), activities mainly concerned the improvement and completion of the TBM engineering design. Within the frame of the Helium Cooled Pebble Bed concept programmes, studies about the development of Li2TiO3 pebbles are on going. The main objective of 2005 which was to improve the shape of Li2TiO3 pebbles has been successfully achieved. EURATOM-Cea maintained significant involvement in the development of structural materials for a fusion reactor. A strong effort has been made on a program of laser detritiation associated with remote handling. (A.C.)

  13. 188Re-IorCEA1 as radioimmunotherapeutical agent: Preparation and evaluation

    International Nuclear Information System (INIS)

    Effective immunotherapy of human malignancies requires the selective delivery of these agents to relevant antigen-expressing tumour cells. A variety of strategies have been investigated to achieve this objective. It has very clearly established that ior-CEA1 monoclonal antibody is an extremely good agent for immunoscintigraphy with a high sensitivity (94%) and specificity (87%) (OLIVA 94, OLIVA 95). Ior-CEA1 is hence a good candidate for development as a therapeutic agent. Moreover, it is an attractive novel protein, which conserves its biological properties, despite chemical treatment. Radiolabelling of ior-CEA1 is accomplished by a direct method using 2-mercaptoethanol as the reducing agent. Two different weak chelating agents were employed, which had been reported in other published works before. All experiments carried out with MDP showed low labelling yields and high precipitate formation, even while SnF2, which has better redox properties. The best labelling yields were attained with low citric acid concentration, as well as with 400 μg of SnF2 at pH 3. The optimised method gave high labelling yields (∼ 95 %). The best labelling yields were attained with low citric acid concentration, which was used as a weak transchelation ligand. Ascorbic acid and Albumin could be used as the stabilising agents in order to achieve less than 3,5% dissociation

  14. Value of human chorionic gonadotropin compared to CEA in discriminating benign from malignant effusions.

    Science.gov (United States)

    Lamerz, R; Stoetzer, O J; Mezger, J; Brandt, A; Darsow, M; Wilmanns, W

    1999-01-01

    Human chorionic gonadotropin (HCG) is expressed in germ cell tumors and urothelial, breast, lung and colon cancers. The aim of the study was to investigate if the determination of HCG in comparison with CEA is able to discriminate between malignant and benign effusions. Effusion and partially serum samples of 61 patients with benign (g.i., heart/kidney isnuff.) and 116 patients with malignant diseases (g.i., gynec., lung, misc., CUP) were investigated. HCG was specifically determined by an IRMA using 2 monoclonal antibodies, CEA by a conventional double Ab RIA. Cytological staining was preformed using the Pappenheim-method on cytospin preparations. Significant differences (p gynec. (32.1%) gynec. (60%) pleural effusions with high specificity (90% at 5 IU/l) but low sensitivity of 31% increasing in g.i., lung and gynecologic cases, CEA a more general TM with higher sensitivity of 45% increasing in g.i., gynecologic and lung cases (sp. 100% at 9 ng/ml) both adding significantly to cytology-negative effusions. PMID:10470169

  15. FDG-PET scan in patients with clinically and/or radiologically suspicious colorectal cancer recurrence but normal CEA

    OpenAIRE

    Zhang Jun; Povoski Stephen P; Bloomston Mark; Sarikaya Ismet; Hall Nathan C; Knopp Michael V; Martin Edward W

    2007-01-01

    Abstract Background Although frequently used for tumor surveillance, the sensitivity of carcinoembryonic antigen (CEA) to detect recurrent colorectal cancer (CRC) is not optimal. Fluorine 18-fluoro-2-deoxy-glucose-positron emission tomography (18F FDG-PET) scans promise to improve recurrent CRC detection. We aimed to review PET scans of patients with clinically and/or radiologically suspicious tumor recurrence but normal CEA. Methods A retrospective review of an electronic database of 308 pat...

  16. Fusion technology annual report of the association EURATOM/CEA 1998; Technologie de la fusion Rapport annuel 1998 Association EURATOM/CEA 1998

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le vagueres, F

    1998-07-01

    In this book are found technical and scientific papers on the main works carried out in the frame of the european program of fusion technology, during 1998. The presented activities are: plasma facing components, vacuum vessel and shield, magnets, remote handling, safety (short and long term), european blanket project (long term) with water cooled lithium lead and helium cooled pebble bed blanket, materials for fusion power plant, socio-economic research on fusion, plasma facing components, fuel cycle, inertial confinement. (A.L.B.)

  17. Detection of hTERT mRNA, CEA, CA19-9 in Pleural Effusion and Its Clinical Significance

    Institute of Scientific and Technical Information of China (English)

    Niangui Zhao; Xiaoqun Ye; Weilan Yang; Yeqing Zou; Chunsong Yan

    2008-01-01

    OBJECTIVE To explore the clinical significance of the human telomerase reverse transcriptase (hTERT) mRNA, CEA and CA19-9 in differential diagnosis of benign and malignant pleural effusions.METHODS Concentrations of CEA and CA19-9 in pleural effusions were assayed using automated chemiluminescence, and expression of hTERT mRNA was detected by RT-PCR.RESULTS The positive rates of hTERT mRNA, CEA and CA19-9 expression in the group with malignant effusions were significantly higher compared to the group with benign effusion(P < 0.05). The sensitivity (%), specificity (%) and diagnostic accordance rates (%) of the 3 tumor markers were as follows: I)hTERT mRNA: 81.8/90.5/86.1; ii) CEA: 52.3/92.9/72.1; iii) CA19-9:34.1/90.5/61.6. The positive rates of hTERT mRNA + CEA (%)expression in the pleural effusions were 97.7.CONCLUSION All of these tumor markers can be helpful for differential diagnosis of pleural effusions, hTERT mRNA had more clinical value in differentiation of the pleural efffusions.CA19-9 is unfit to be as an optimal index. The combined assay of hTERT mRNA and CEA in pleural effusions can further raise the positive detection rate of the tumor markers and can be helpful in producing a diagnosis.

  18. Lithium/polymer batteries. Safety approach of the BT-EDF-CEA project; Accumulateurs lithium/polymere. Demarche securite du projet BT-EDF-CEA

    Energy Technology Data Exchange (ETDEWEB)

    Lascaud, S.; Baudry, P. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches; Majastre, H. [Bollore Technologies, 29 - Quimper (France); Bloch, D. [CEAGrenoble, CEREM, 38 (France)

    1996-12-31

    The BT-EdF-CEA consortium for the development and the performance improvement of lithium/polymer batteries has carried out a safety analysis of the industrial risk and the risk for users linked with this new technology. The process chosen for the manufacturing of lithium/polymer batteries does not generate any particular risk of personnel or environmental contamination. Security tests have permitted to observe and analyze the behaviour of 4 Ah elements during thermal shocks, perforation and crushing, and during external short-circuit on 20 Ah elements. These tests demonstrate the great thermal stability and the excellent behaviour of batteries in the case of partial destruction. (J.S.) 2 refs.

  19. “Bridging the Gap between International Investment Law and the Environment”, 4th and 5th November, The Hague, The Netherlands

    Directory of Open Access Journals (Sweden)

    Rosalien Diepeveen

    2014-02-01

    Full Text Available This contribution is based on the discussions that took place in the international conference “Bridging the Gap between International Investment Law and the Environment” which was held on 4-5 November 2013 in the Hague. The main goal of the conference was to answer the question of how the gap between international investment law and the environment can be bridged. Different perspectives were presented, helping to shed light on this issue. The emphasis of the first day of the conference was the academic debate in the field of international investment law and the environment. Four main perspectives were discussed: general principles of international investment law and the environment, various legal regimes, specific legal regimes and case studies. Furthermore, also the topics of sustainable development, the right to access to water and climate change were elaborated upon by the experts. The second day of the conference focussed on the perspective of policy-makers. Most of the topics were presented in the form of panel discussions. Issues that were discussed included: the perspective of various intergovernmental organisations, concerns and dilemmas of non-European capital-importing countries, and the European Investment Policy. This contribution elaborates upon the most important themes and issues debated at the conference, providing academic and policy perspectives.

  20. The Prospect of Enforcement of Hague Arbitration Awards against State-Controlled Companies in the United States and the United Kingdom

    Directory of Open Access Journals (Sweden)

    Dmitry Gololobov

    2015-12-01

    Full Text Available In 2014 the Permanent Arbitration Court in The Hague made unprecedented awards totalling US$50 billion against the Russian Federation. The awards crowned more than nine years of arbitration proceedings initiated by the former shareholders of the liquidated oil company Yukos. Although the former shareholders of Yukos represented by the GML Group declared their intention to only enforce the awards against the assets of the Russian state, the lack of assets not covered by state immunity inevitably opens the possibility of enforcement of the awards against the assets owned by the Russian majors controlled by the state. Due to its involvement in the Yukos case, Rosneft, the biggest Russian oil company, will undoubtedly be the first and the main target of such enforcement. This article aims to examine whether the former shareholders of Yukos could succeed in enforcement of foreign arbitration awards in the two main jurisdictions: the United Kingdom and the United States. The article examines the existing legal tests applicable in enforcement proceedings in these jurisdictions to state-controlled companies by considering the corporate structure of Rosneft and its business operations. The findings of the research are widely applicable to the other state-controlled Russian companies.

  1. El teatre català del segle XIX i la realitat catalana de l'època

    Directory of Open Access Journals (Sweden)

    Ramon Bacardit

    2014-02-01

    a la realitat contemporània immediata, bé a través del reflex directe com en les obres d’actualitat de Jaume Piquet, bé amb el recurs a la distanciació històrica o de clixés costumistes com en el cas de Soler. A la llarga, el model de realitat iteraturitzable consolidat s’hagué d’enfrontar a les demandes del realisme literari de configurar una altra convenció del real.

  2. Control biológico de enfermedades mediante el tratamiento de semillas de cucurbitáceas con rizobacterias promotoras del crecimiento de las plantas (PGPR)./Biological control of diseases by cucurbits seeds treatment with rhizobacteria plant growth promoting (PGPR).

    OpenAIRE

    Gilda Jiménez Montejo; Jesús Mena Campos; Yamilka Ramírez Núñez

    2014-01-01

    Resumen:Las regulaciones sobre la producción de alimentos sanos limitan actualmente el uso de fungicidas sintéticos para el tratamiento de semillas y, por otra parte, no se dispone de bactericidas efectivos. Se condujeron experimentos en condiciones controladas para evaluar el efecto de las cepas de rizobacterias antagonistas Bacillus subtilis F16/95, B. subtilis Xph y Pseudomonas putida 14A en el control biológico de la Mancha bacteriana de las cucurbitáceas, la Mancha bacteriana del fruto...

  3. AIRIX: an induction accelerator facility developed at CEA for flash radiography in detonics

    Science.gov (United States)

    Cavailler, Claude

    1999-06-01

    AIRIX is an induction linear accelerator which will be used for flash radiography in CEA/DAM. Designed to produce an X-ray dose of more than 500 Rads at 1 meter with an X-ray focal spot size diameter of less than 2 mm (LANL-CEA DAM definition), this facility consists in a 4 MeV/3.5 kA pulsed electron injector and 16 MeV induction accelerator powered by 32 high voltage generators. A prototype of this accelerator, called PIVAIR, has been studied and realized in CEA CESTA near Bordeaux. PIVAIR is a validation step for AIRIX at 8 MeV. It includes an injector (4 MeV, 3.5 kA, 60 ns) and 16 inductor cells supplied by 8 high voltage generators (250 kV, 70 ns). Two different technologies of induction cells have been tested (rexolite insulator or ferrite under vacuum). We have chosen ferrite under vacuum cells technology after comparison of results on beam transport and reliability tests. A focusing experiment at 7.2 MeV of the electron beam as been achieved during summer 1997. We have begun to produce X-rays in October 1997. A dose level of 50 Rad at 1 meter has been achieved with an X-ray spot size diameter of 3.5 to 4 mm (LANL-CEA DAM definition). Static flash radiography of very dense object have been achieved from November 97 until February 98. We have been able to test in situ new kinds of very high sensitive X- ray detectors and to check they had reached our very ambitious goals: (1) quantum efficiency at 5 MeV greater than 50% instead of 1% for luminous screens and film; (2) sensitivity less than 10 (mu) Rad (100 time more sensitive than radiographic luminous screens and films); (3) dynamic range greater than 100; (4) resolution less than 2 mm. We will present in this communication brand new kinds of detection systems, called high stopping power detectors, such as: (1) (gamma) camera with segmented thick crystal of BGO and MCP image intensifier; (2) multistep parallel plate avalanche chamber; (3) pixellized CdTe MeV photoconductor matrix. AIRIX accelerator is being

  4. Actinides exposure: review of Ca-DTPA injections inside Cea-Cogema plants

    International Nuclear Information System (INIS)

    Ca-DTPA has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This report is a survey of the injections administered of Ca-DTPA as a chelating molecule. This report will be a part of the AMM process for Ca-DTPA by intravenous administration submitted by the Central Pharmacy of the french Army. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contaminations were reported. These employees were followed by occupational physicians according to the current regulations. The first part of the report is a synthesis of the most recent findings. Due to its short biological period and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary. The second part presents data concerning these 1158 injections (way of contamination, posology, adverse effects...). These incidents took place at work, were most often minor, not requiring follow-up treatment. A study concerning the effectiveness of the product was done on a group of people having received 5 or more injections. These results were compared with effectiveness estimated from theoretical basis. Posologies and therapeutic schemes were proposed based on these observations. Additional studies are needed to confirm these findings. This document is the first synthesis in this field. It is the result of a collective work having mobilized the occupational medicine departments, the laboratories of CEA and COGEMA and a working group CEA-COGEMA-SPRA. (authors)

  5. CEA studies and qualifications prior to the JT-60SA TF coils manufacture

    International Nuclear Information System (INIS)

    Following the first conceptual design activity in which the general design of the JT-60SA TF system was defined in agreement with all the participants in the project (CEA, ENEA, F4E), a second phase dealing with the detailed design was engaged by each of the voluntary contributors. For the French part which includes the procurement of 9 of the TF winding packs and their integration in the casing, an industrial contract was signed mid 2011 with Alstom (France). Several actions have been carried out to prepare the manufacturing phase. To precisely define one of the main interfaces which is the temporary electrical connection of the coils to the current leads during cold test in the CEA facility as well as their final connection to the feeders at the Naka site, a design compatible with both requirements was developed by CEA, supported by the previous developments led on the joints and assembly techniques. In addition to prepare the coils manufacture, hydraulic qualification was led on the first conductor qualification length to set the parameters which will be used by the coils manufacturer for conductor acceptance. At last, mechanical characterizations of both the conductor and of the empty compacted jacket were performed in order to define as precisely as possible the elastic and plastic properties of these components. These are crucial properties used during the bending process which is one of the most important operations during the winding pack manufacture. These data will be very helpful for the winding machine parameters settings as well as for designing the local bending tooling needed to shape the conductors extremities at the connection area and at the double pancakes joggles

  6. Annual report of the Association EURATOM-Cea 2004 (full report)

    International Nuclear Information System (INIS)

    This annual report summarizes activities performed by the EURATOM-Cea association in 2004. The activities carried out in the field 'physics integration' are mainly linked to neutral beam developments and to the development of diagnostic components. In particular, in-situ diagnostics of the plasma facing surface have been studied. Concerning 'vessel activities', the manufacturing of the ITER primary first wall panel by HIP forming has been investigated. A dummy mock-up was produced to validate the manufacturing feasibility. A new welding process able to improve welding productivity has been investigated, it is based on a hybrid laser/TIG process called Hybrid Laser Conduction Welding. A ITER first wall mock-up has been successfully manufactured using induction brazing. In the field 'magnets', EURATOM-Cea association was involved to provide input information for establishing the final dimension details of the ITER cryo-plant. EURATOM-Cea is also involved with the design of different parts of the ITER magnet system and the fabrication of mock-ups for some critical parts of the coils. In the field 'tritium breeding and materials', activities have mainly concerned the improvement and completion of the TBM (tritium breeding module) engineering design. A new batch of 1 kilogram of Li2TiO3 pebbles with a size distribution in the range 0.6 to 0.8 mm was produced in 2004. Concerning materials, activities were focused on the EUROFER, a reduced activation martensitic steel. Activities performed in the field 'system studies' are dedicated to the power plant conceptual studies. In 2004, activities were focused on the reactor model AB, based on a helium-cooled lithium-lead blanket. (A.C.)

  7. Prognostic value of monitoring tumour markers CA 15-3 and CEA during fulvestrant treatment

    Directory of Open Access Journals (Sweden)

    Locker Gottfried J

    2006-03-01

    Full Text Available Abstract Background At many centres tumour markers are used to detect disease recurrence and to monitor response to therapy in patients with advanced disease, although the real value of serial observation of marker levels remains disputed. In this study, we evaluated the prognostic value of tumour markers for predicting response (partial response [PR], stable disease [SD] ≥ 6 months, de novo disease progression (PD and secondary PD in patients receiving fulvestrant ('Faslodex' 250 mg/month for the treatment of metastatic breast cancer (MBC. Methods Changes in cancer antigen 15–3 (CA 15-3 and carcinoembryonic antigen (CEA were prospectively monitored (monthly and were also evaluated for the 3 months preceding secondary PD. Data from 67 patients with previously treated MBC participating in a Compassionate Use Programme were analysed. Results In patients with a PR (n = 7 [10.4%], a non-significant increase in CA 15-3 occurred during the first 6 months of treatment; CEA was significantly reduced (P = 0.0165. In patients with SD ≥ 6 months (n = 28 [41.8%], both CA 15-3 (P P = 0.0399 levels increased significantly after 6 months treatment. In those experiencing de novo PD (n = 32 [47.8%], CA 15-3 increased significantly (P P = 0.0002 during the same time period. Both CA 15-3 (P P Conclusion CA 15-3 increases in patients progressing on fulvestrant but may also increase in those experiencing clinical benefit; this should not be taken as a sign of PD without verification. Overall, both CA 15-3 and CEA appear to be poor prognostic markers for determining progression in patients receiving fulvestrant.

  8. Report on nuclear safety and transparency 2011 - NBI operated by the CEA in Marcoule

    International Nuclear Information System (INIS)

    After a brief presentation of the Marcoule CEA centre, this report indicates the different safety measures related to different risks, to emergency situations, to inspections and audits, and to nuclear base installations (INB). It describes measures related to radiation protection and some remarkable facts which occurred in 2010. It presents the different significant events which occurred in 2011 and were declared to the ASN. It discusses the results of measurements of releases from the installations and their impact on the environment. It addresses the radioactive wastes which are warehoused on the site (measures to limit their volume and to limit their impact on health and on the environment, notably on water and soils)

  9. Decay heat calculations with the CEA radioactivity data bauk and the code PEPIN

    International Nuclear Information System (INIS)

    The CEA radioactivity data bank, has been updated mainly from ENSDF and from some recent experimental results. This library contains the decay data for about 700 fission products (F.P.), 220 actinides and more than 1400 other nuclides. A comparison between our data and ENDF/B5 is shown for the fission products. The fission products part of this library is currently used for shielding and decay heat calculations with the PEPIN code. Calculations and spectral comparisons of the available experiments (Dickens, Lott, Yarmell ...) and other recent calculations is made for thermal fission of 235U and 239Pu using our data bank as input

  10. Ocular rosacea: a review Rosácea ocular: revisão

    Directory of Open Access Journals (Sweden)

    Ana Carolina Cabreira Vieira

    2012-10-01

    Full Text Available Rosacea is a prevalent chronic cutaneous disorder with variable presentation and severity. Although considered a skin disease, rosacea may evolve the eyes in 58-72% of the patients, causing eyelid and ocular surface inflammation. About one third of the patients develop potentially sight-threatening corneal involvement. Untreated rosacea may cause varying degrees of ocular morbidity. The importance of early diagnosis and adequate treatment cannot be overemphasized. There is not yet a diagnostic test for rosacea. The diagnosis of ocular rosacea relies on observation of clinical features, which can be challenging in up to 90% of patients in whom accompanying roseatic skin changes may be subtle or inexistent. In this review, we describe the pathophysiologic mechanisms proposed in the literature, clinical features, diagnosis and management of ocular rosacea, as well as discuss the need for a diagnostic test for the disease.A rosácea é uma condição cutânea crônica, que possui apresentações clínicas variáveis. Apesar de considerada uma doença dermatológica, os olhos podem ser acometidos em 58-72% dos casos, causando inflamação palpebral e da superfície ocular. Aproximadamente um terço dos pacientes desenvolve acometimento corneano, podendo causar baixa visual significativa. Diagnóstico precoce e tratamento adequado são de extrema importância, devido à significativa morbidade ocular que a doença pode causar. Não há, até o momento, um teste diagnóstico para rosácea. O diagnóstico da rosácea ocular depende da observação das manifestações clínicas, o que pode ser bastante desafiador em até 90% dos pacientes, em que os achados cutâneos são discretos ou inexistentes. Nesta revisão, descrevemos os mecanismos fisiopatológicos propostos na literatura, manifestações clínicas, diagnóstico e tratamento da rosácea ocular, assim como abordamos a necessidade de um teste diagnóstico.

  11. Introduction to CEA studies on future nuclear energy systems and nuclear desalination

    International Nuclear Information System (INIS)

    Nuclear energy has unique assets to meet the requirements for sustainable development in terms of economic competitiveness, safety, environmental friendliness and natural resources saving. The growth in world energy demand and future prospects of the decommissioning of existing power plants has stimulated the development of a new generation of nuclear energy systems intended to be more economically competitive, safer and more sustainable. The French Atomic Energy Commission (CEA) is strongly involved in advancing nuclear energy technology to meet future energy needs. The Generation IV Initiative provides an adequate framework to organise future R and D efforts for the development of innovative nuclear systems able to meet the requirements of a sustainable energy policy in terms of economic competitiveness, safety, environmental friendliness and natural resources saving. While covering most reactor technologies, the effort of the CEA is essentially focused on the development of a three-step set of gas-cooled systems. Besides the development of new concepts, the need to provide potable water to the expanding population in arid regions is potentially an emerging application for nuclear power. Its practical implementation requires parallel efforts to develop the needed technologies and to address specific aspects of their coupling with nuclear power plants. After a short recall on the Gen IV goals for future nuclear energy systems, the paper motivates the selection of a consistent range of high temperature gas cooled modular systems as a major focus for future studies. A preliminary overview of the reference concepts for the innovative set of gas cooled nuclear systems - namely the Very-High-Temperature Reactor (VHTR) and the Gas-Cooled Fast Reactor System (GFR) is given. Finally, the CEA's activities on nuclear desalination are quickly discussed: the EURODESAL project within the 5th R and D Framework Programme of the European Union; the TUNDESAL project, which is a

  12. Charting a course through the CEAs: diagnosis and management of medullary thyroid cancer.

    Science.gov (United States)

    Rowe, Christopher W; Bendinelli, Cino; McGrath, Shaun

    2016-09-01

    Medullary thyroid cancer (MTC) is an uncommon thyroid cancer that requires a high index of suspicion to facilitate diagnosis of early-stage disease amenable to surgical cure. The challenges of diagnosis, as well as management in the setting of persistent disease, are explored in the context of a case presenting with the incidental finding of elevated carcinoembryonic antigen (CEA) and an (18) F-fluorodeoxyglucose positron emission tomography ((18) F-FDG-PET)-positive thyroid incidentaloma detected following treatment of colorectal cancer. Strategies to individualize prognosis, and emerging PET-based imaging modalities, particularly the potential role of (18) F-DOPA-PET in staging, are reviewed. PMID:27230389

  13. The evaluation of the nuclear facilities safety at the CEA from 1999 to 2001

    International Nuclear Information System (INIS)

    The aim of this document is the presentation of an evaluation of the problems and the safety methods in the concerned period. The first chapter presents the nuclear safety in the CEA. The second chapter is devoted to the organization and the quality for the safety: liabilities, audits, relations with the safety authorities and with the public. The chapters three and four deal respectively with the methodological and technical abilities supporting the exploitation teams and with the nuclear safety projects. The last chapter presents the experiments and events from 1999 to 2001. (A.L.B.)

  14. Evaluation of the radiology state at the CEA/Fontenay-aux-Roses and its environment

    International Nuclear Information System (INIS)

    Since 1946 the nuclear installations followed one other at the CEA of Fontenay-aux-Roses still their gradual stop the last ten years, except two installations INB34 and INB73, necessary for the wastes management. Today these installations form the subject of a drainage program. The public opinion is regularly informed on this program since 1999. This document presents the stock of the actions realized since this date: the track keeping of the sites activities impacts on the environment and the actions realized since 1999. (A.L.B.)

  15. Changes in soluble CEA and TIMP-1 levels during adjuvant chemotherapy for stage III colon cancer

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Christensen, Ib Jarle; Sölétormos, György; Jess, Per; Nielsen, Svend Erik; Brünner, Nils; Nielsen, Hans J.

    2010-01-01

    Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antige...... (CEA) levels in patients with stage III colon cancer.......Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antigen...

  16. List of reports from reactor safety research of BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning special Problems in the field of Reactor Safety Research. According to the cooperation of the Bundesminister fuer Forschung und Technologie (BMFT) with the Commissariat a l'Energie Atomique (CEA), the Japan Science and Technologie Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these Reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programm of the BMFT, reporting organization. The list of reports appears quarterly. (orig.)

  17. Annual report of the Association EURATOM-Cea 2004 (executive summary)

    International Nuclear Information System (INIS)

    Progress in fusion technology is constant over the years and this report once again highlights a number of important steps that have been accomplished in this domain. This document is the executive summary of the full annual report, summarizing activities performed by the EURATOM-Cea association. This report has been organized into 10 issues: 1) physics integration, 2) reactor vessel, 3) plasma facing components, 4) remote handling, 5) magnets structures, 6) tritium breeding blankets, 7) structural material, 8) safety and environment, 9) system study, and 10) ITER site preparation

  18. Annual report of the Association EURATOM-Cea 2005 (executive summary)

    International Nuclear Information System (INIS)

    Progress in fusion technology is constant over the years and this report once again highlights a number of important steps that have been accomplished in this domain. This document is the executive summary of the full annual report, summarizing activities performed by the EURATOM-Cea association. This report has been organized into 10 issues: 1) physics integration, 2) reactor vessel, 3) plasma facing components, 4) remote handling, 5) magnets structures, 6) tritium breeding blankets, 7) structural material, 8) safety and environment, 9) system study, and 10) ITER site preparation

  19. research document no. 27 bis. After the Hague, Bonn and Marrakech: the future international market for emissions permits and the issue of hot air

    International Nuclear Information System (INIS)

    The main objective of this paper is to assess the Bonn-Marrakech agreement, in terms of abatement cost and emission trading as compared with the initial agreement reached in Kyoto (the Kyoto Protocol). Our reference case (the Initial Deal) does not include the use of sinks credits, as the Kyoto Protocol does not give explicit figures nor method to estimate them. In addition, two hypothetical situations are considered. The first describes the ''missed compromise'' that could have emerged among all Parties in November 2000 in The Hague. The second is a virtual case where the US is assumed to be part of the Bonn-Marrakech Agreement, along with all the other Parties. These two cases contribute to shed the light on the Bonn-Marrakech Agreement potential pitfalls. In the current situation, the US is out of the negotiation process and has no emission reduction commitment. Given the projections of carbon dioxide (CO2) emissions used in this study, the Former Soviet Union countries (FSU) and the Eastern European Economies (EEE) that are part of the Annex B have potentially enough Hot Air to fulfill the overall commitment of the Annex B bubble, without any domestic abatement effort from the other Annex B countries. We show that in the theoretical case where no limit would be imposed on the selling of Hot Air, the permit price according to the POLES model would be zero as no market equilibrium could take place. This is why, next, we examine the economic impacts of restrictions to hot air trading, for FSU and EEE as well as for the other countries. We shed the light on the potential market power of the former countries that arises from the Bonn-Marrakech Agreement. (author)

  20. CEA program on future generation light water modular reactors and gas cooled reactors

    International Nuclear Information System (INIS)

    The CEA programme on 'Future Generation Reactors and Fuel Cycles' aims at studying and developing the mean and long term most promising options for nuclear reactors, fuels and reprocessing. These options should contribute to make the nuclear energy a major source of the sustainable development. The program also aims at maintaining at the highest level of competency the technologies with which the CEA will be able to bring to national achievements or international projects in the next decades, projects whose specifications and calendar are today unknown. These studies on the 'Future Generation Reactors and Fuel Cycles' constitute a field privileged for international collaboration. The corresponding researches are structured in four main axes: Innovations for LWR; Systems of 4th generation; Sodium-cooled reactors; Systems which are the object for survey or exploratory studies. Studies on future nuclear gas technologies are mainly covered by the 4th generation programme (Gen IV). Within this context, the goals pursued, in particular the minimization of the production of long lived waste and the saving of resources (i.e.: the optimised utilisation of fissile and fertile nuclear fuels), could justify an evolution towards hard neutron spectra and high temperatures, to cover applications other than the electricity production, e.g.: hydrogen production, desalination, cogeneration. The main R and D axis for these long-term objectives currently the area of Gas Cooled Reactors (GCR). The corresponding program is structured through eight R and D projects details of which are presented within the paper. (author)

  1. Overview of the CEA R and D support to generation IV nuclear energy systems

    International Nuclear Information System (INIS)

    As a result of an early technology road-map performed at the end of 2000, the CEA selected a sequenced development of advanced gas cooled high temperature nuclear systems as main focus for its R and D programme on future nuclear energy systems. The selection of this research objectives originates both from the significance of fast neutrons and high temperature for nuclear energy to meet the needs anticipated beyond 2020/2030, and from the significant common R and D pathway that supports both medium term industrial projects and more advanced versions of gas cooled reactors. The first step of the 'Gas Technology Path' aims to support the development of a modular HTR likely to meet international market needs around 2020. The second step is a Very High Temperature Reactor (> 950 deg. C) to efficiently produce, among others, hydrogen though thermo-chemical water splitting or to generate electricity with an efficiency above 50%. The third step of the Path is a Gas Fast Reactor that features a fast-spectrum helium-cooled reactor and closed fuel cycle, with a direct-cycle helium turbine for electricity production and full recycle of actinides. The paper succinctly presents the R and D program launched in 2001 by the CEA with industrial partners on the 'Gas Technology Path', which is destined to become the contribution of France to the development of the VHTR and the GFR within the next phase of the Generation IV Forum

  2. 2007-2008 activity report of the Association EURATOM-CEA (Full Report)

    International Nuclear Information System (INIS)

    This document summarizes the activities performed by EURATOM-CEA association in 2007-2008. The activities are various and have involved different issues like the study of dust generation processes and measurement techniques, ICRH antenna design for heating, integration studies inside the port-plug for diagnostics and in-situ divertor thermography, or the helium cooled lithium lead (HCLL) breeding blanket concept. Activities have been made to study the properties of the line defects governing the plastic behavior of iron base materials. Different options have been investigated for the superconducting magnet system. The measurement of in-vessel tritium inventory by laser induced breakdown spectroscopy (LIBS) technique has been investigated. 2007-2008 were also dedicated to the manufacture and complete tests of the AIA (Articulated Inspection Arm). AIA is designed to inspect divertor cassettes and the vacuum vessel first wall. Activities based on safety analysis or tests of ITER safety open issues have been carried out using several CEA facilities and expertise. This document is divided into 5 sections: 1) physics integration, 2) in-vessel, 3) magnet system and cryogenics, 4) tritium breeding and materials, 5) safety and environment, 6) system studies, 7) design support and procurement, 8) JET technology

  3. Significance of the fuel cycle aspects in CEA studies on future nuclear systems

    International Nuclear Information System (INIS)

    Nuclear energy has unique assets to meet the requirements for a sustainable development in terms of economic competitiveness, environmental friendliness and natural resources saving. Future nuclear system studies conducted by the CEA aim at investigating and developing promising technologies for the medium and the long term for reactors, fuels and the fuel cycle to make nuclear power eligible as one of the major energy sources of the sustainable development. It also aims at maintaining at the best possible level the expertise and the technologies that the CEA will be able to bring to future national and international projects likely to meet market needs in the next decades, which are still uncertain both in terms of performances and time scale. Progress for future nuclear systems is principally sought in the following areas: reinforced economic competitiveness against other available electricity generation means, with a special emphasis put on reducing the investment cost; enhanced safety, especially through an increased resistance to core damages in case of severe accident, and whenever possible by dedicated strategies to exclude core melting; cleanliness through minimising the production of long lived radioactive waste; resource saving through an optimum utilisation of the available resources of fissile and fertile materials; enhanced resistance to proliferation risks; potentialities for other applications than electricity production. (author)

  4. Research and development performed at CEA/DMT in the field of nuclear reactors containments

    International Nuclear Information System (INIS)

    The behavior of containment is a key issue with respect to the safety of nuclear power plants. Extensive work has been performed for many years at CEA/DMT (Department of Mechanics and Technology) on this subject particularly on the behavior of containment under severe accidents. Large research and development programs have been carried out and are still under progress to handle the following problems: thermo-mechanical response on the containment under increasing pressure and temperature up to the ultimate behavior of the structure; behavior of the containment in case of hydrogen detonation or steam explosion; modelization and evaluation of containment leaking after a severe accident inducing cracks in the structure; and response of the containment to seismic loads. These studies have been carried out by means of finite element computations. The computer codes have been developed and validated using either analytical solutions or experimental results. Specific developments have been made in order to be able to solve the above mentioned problems: material models for reinforced concrete; fast dynamic algorithms for impacts; seismic analysis techniques and soil-structure interactions; and gas dynamics, shock waves and fluid-structure interaction. More recently, new programs have also been undertaken, concerning the behavior of containment after core melt and vessel break through. Work is in progress at CEA/DMT in the two following areas: conceptual studies concerning core catcher and residual power evacuation and design method development of core catcher, including numerical code development

  5. Development of a DNBR evaluation method for the CEA ejection accident in SMART core

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Dae Hyun; Yoo, Y. J.; In, W. K.; Chang, M. H. [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-12-01

    A methodology applicable to the analysis of the CEA ejection accident in SMART is developed for the evaluation of the fraction of fuel failure caused by DNB. The transient behavior of the core thermal-hydraulic conditions is calculated by the subchannel analysis code MATRA. The minimum DNBR during the accident is calculated by KRB-1 CHF correlation considering the 1/8 symmetry of hot assembly. The variation of hot assembly power during the accident is simulated by the LTC(Limiting transient Curve) which is determined from the analysis of power distribution data resulting from the three-dimensional core dynamics calculations. The initial condition of the accident is determined by considering LOC(Limiting Conditions for Operation) of SMART core. Two different methodologies for the evaluation of DNB failure rate are established; a deterministic method based on the DNB envelope, and a probabilistic method based on the DNB probability of each fuel rod. The methodology developed in this study is applied to the analysis of CEA ejection accident in the preliminary design core of SMART. As the result, the fractions of DNB fuel failure by the deterministic method and the probabilistic method are calculated as 38.7% and 7.8%, respectively. 16 refs., 16 figs., 5 tabs. (Author)

  6. Activities on the physics of accelerator-based systems at CEA

    International Nuclear Information System (INIS)

    Nowadays, the interest for accelerator-based systems (ABS) in France is strongly related to the studies on long-lived radioactive waste management. Investigations aim to indicate whether ABS can play a role beside critical reactors in the process proposed to reduce the long term radiotoxicity of nuclear wastes. ABS is not envisaged to replace reactors for energy production even if the energy production is a mean to reduce the transmutation cost. Several French organisms (CEA, EDF, CNRS) are interested by ABS studies. Activities are shared out amongst different laboratories and involve international cooperation. The program aims at evaluating ABS performances for the report on waste management foreseen in 2006 and not at developing a project. This ABS evaluation concerns the following items: potential of radiotoxicity reduction, safety, economy, feasibility which must be compared with those of critical reactors. To achieve this end, activities at CEA are in progress on: - code development and validation, - nuclear data evaluation, -theoretical investigations on ABS characteristics, - study of existing projects. (author) 2 figs., 2 tabs., 8 refs

  7. Treatment of actinide exposures: a review of Ca-DTPA injections inside CEA-COGEMA plants

    International Nuclear Information System (INIS)

    Calcium diethylenetriamine pent-acetate (Ca-DTPA) has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This paper is a survey of the injections Ca-DTPA administered as a chelating molecule and it will be a part of the authorization process for Ca-DTPA by intravenous administration. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contamination were reported. These employees were followed by occupational physicians according to the current French regulations. These incidents took place at work, were most often minor, not requiring follow-up treatment. The authors present (1) a synthesis of the most recent findings. Due to its short biological half-time and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary (2) data concerning these 1158 injections (route of contamination, dosage, adverse effects, etc.) The authors also investigated a study on the efficacy of the product on a group of persons having received five or more injections. These results were compared with the efficacy estimated theoretically. Dosages and therapeutic schemes were proposed based on these observations. This synthesis is the result of a collective work having mobilized the occupational medicine departments, the medical laboratories inside a working group CEA-COGEMA-SPRA. (authors)

  8. 2007-2008 activity report of the Association EURATOM-CEA (Executive summary)

    International Nuclear Information System (INIS)

    This document is the executive summary of the full report, summarizing activities performed by EURATOM-CEA association in 2007-2008. The activities are various and have involved different issues like the study of dust generation processes and measurement techniques, ICRH antenna design for heating, integration studies inside the port-plug for diagnostics and in-situ divertor thermography, or the helium cooled lithium lead (HCLL) breeding blanket concept. Activities have been made to study the properties of the line defects governing the plastic behavior of iron base materials. Different options have been investigated for the superconducting magnet system. The measurement of in-vessel tritium inventory by laser induced breakdown spectroscopy (LIBS) technique has been investigated. 2007-2008 were also dedicated to the manufacture and complete tests of the AIA (Articulated Inspection Arm). AIA is designed to inspect divertor cassettes and the vacuum vessel first wall. Activities based on safety analysis or tests of ITER safety open issues have been carried out using several CEA facilities and expertise

  9. Report of the CEA visiting committee on R and D for future nuclear energy systems, May 11-13, 2005

    International Nuclear Information System (INIS)

    This was the fifth meeting of the Visiting Committee of the CEA since its creation in year 2000. The first meeting gave members of the committee a broad overview of the entire spectrum of CEA research and subsequent meetings have focused on specific topics. These included the nuclear fuel cycle, biology, and micro and nano technologies. This meeting focused on research and development for future nuclear energy systems. The main division of CEA concerned with this topic is the Nuclear Energy Division. Some of the laboratories of the Technological Research and Matter Science Divisions are also involved in areas such as materials and basic nuclear data. The report deals with the fuels and waste, the SFR (Sodium Fast Reactor) and GFR (Gas Fast Reactor) programs, the Very High temperature reactor (VHTR), the actinide separation, the materials, the irradiation tests facilities and the personnel for the future. (A.L.B.)

  10. Uptake of radiolabeled anti-CEA antibodies in human colorectal primary tumors as a function of tumor mass

    International Nuclear Information System (INIS)

    An inverse correlation has been demonstrated between tumor uptake (u, in units of % injected dose/kg) of monoclonal antibody (Mab) and tumor mass (m, in units of g) for colorectal carcinoma in a series of 19 consecutive patients. The correlation (ρ=-0.510), developed using surgical samples was of the form u=abb and was significant at the 2% level of confidence. All tumors were positive for carcinoembryonic antigen (CEA) and the radiopharmaceutical was in iodine-131 labeled anti-CEA Mab. Such correlations have been predicted earlier from murine and rat tumor uptake data. The slope parameter (b) was -0.362, a number consistent with the previous value (-0.382) found in anti-CEA experiments in mice bearing human xenograft LS174T tumors. (orig.)

  11. The new technology in high temperature gas-cooled reactor. The fifth anniversary of CEA/INET cooperation

    International Nuclear Information System (INIS)

    In 2001, CEA and INET signed the first agreement and a series of specific topics of cooperation (STC), which officially launched the cooperated program on HTGR technology between the two sides, Since 2002, INET has sent dozens of researchers to CEA on both short and long term basis to work with their French counterparts. Over the past five years, they have worked together in a variety of fields, such as materials, fuel, components and reactor physics. Besides, both sides sponsored workshops and technical visits to tackle the major problems. This volume with a collection of papers not only keeps a record of technical progress contributed by both sides, but also marks the fifth anniversary cooperation between CEA and INET. (authors)

  12. An illustration of how sciences may be combined at Cea: parallel progress in superconductivity, particle physics, medical imaging and fusion

    International Nuclear Information System (INIS)

    Superconductivity was hailed as the most important achievement of modern physics when it was discovered in 1911. Since then the enthusiasm has damped a bit because superconductivity still requires very low temperatures. This article gives an historical account of the application of superconductivity to the research programs and achievement of Cea (French atomic energy board). The first uses were dedicated to the design of superconducting magnets. We can note the delivery in 1989 of 246 quadrupolar magnets for bending particle beams for the HERA accelerator. As for the LHC (large hadron collider) project, Cea-Grenoble has a key role in the development of the cryogenic system and Cea-Saclay is responsible of the design of 400 quadrupolar magnets, it will have to fabricate 3 prototypes and the mass production will be made in Germany. A second sector involving superconductivity is thermonuclear devices through magnetic confinement. Tore-Supra has been for 10 years the only big fusion machine involving a superconducting system. In ITER all the coils necessary to the plasma confinement will be superconducting, it will represent 700 tons of superconducting wires. The research programs linked to the ITER project have led to the design of a new superconducting material: the niobium-tin (Nb3Sn). A third sector is medical imaging in which Cea is involved since the eighties. Cea-Saclay will home the Neurospin center whose purpose is to assess the limit of brain imaging from mice to man. Cea has to design magnets in the range of 11 tesla with a one meter broad clearance, the selected technology is that of superconducting magnets cooled by pressurized superfluid helium. (A.C.)

  13. CEA, CYFRA 21-1, NSE, and ProGRP in the diagnosis of lung cancer: a multivariate approach

    OpenAIRE

    Gruber, Christine; Hatz, Rudolf; Reinmiedl, Judith; Nagel, Dorothea; Stieber, Petra

    2008-01-01

    We retrospectively studied the single and combined diagnostic value of carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA 21-1), neuron specific enolase (NSE) and pro-gastrin-releasing peptide (ProGRP), which were routinely analysed in patients with lung tumours of unknown origin at the time of admission to hospital. Inclusion criteria were the determination of CEA (AxSYM/Abbott), CYFRA 21-1 (ElecSys/Roche) and NSE (Kryptor/Brahms). We examined 1747 patients, where 1325 suffered f...

  14. Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis

    OpenAIRE

    Zhang, Yimin; Yang, Jun; Li, Hongjuan; WU, YIHUA; Zhang, Honghe; Chen, Wenhu

    2015-01-01

    Background: Pancreatic cancer has the worst prognosis and early detection is crucial for improving patient prognosis. Therefore, we performed a meta-analysis to evaluate and compare the sensitivity and specificity of single test of CA19-9, CA242, and CEA, as well as combination test in pancreatic cancer detection. Methods: We searched PubMed, Embase, Medline, and Wanfang databases for studies that evaluated the diagnostic validity of CA19-9, CA242, and CEA between January 1990 and September 2...

  15. The possible role of tumor antigen CA 15-3, CEA and ferritin in malignant and benign disease

    Directory of Open Access Journals (Sweden)

    Nafija Serdarević

    2012-09-01

    Full Text Available Introduction: Serum CA15-3 has been one of the most reliable tumor markers used in monitoring of breast cancer patients. To increase its sensitivity, the combined measurement of other tumor markers (CEA and ferritin with CA15-3 was investigated. The aim of this study was determination of CA 15-3, CEA and ferritin in female patients with breast cancer, lung cancer and mastitisMethods: 300 patients with carcinoma, hospitalized at Department of Gynecologic Oncology and Department for Oncology at the University Clinics Center of Sarajevo and 200 healthy subjects were compared.Results: In patients with breast cancer the mean value of tumor markers were CEA 155.61 ng/mL, CA 15-3 106.38 U/mL and ferritin 197.03 ng/mL. In patients with lung cancer CEA was 58.97 ng/ml, CA 15-3 40.62 U/mL and ferritin 544.16 ng/mL. Patients with mastitis had CEA 5.17 ng/mL, CA 15-3 112.67 U/mL and ferritin 174.92 ng/mL. The control group had values of tumor markers CEA 1.62 ng/mL, CA 15-3 11.72 U/mL and ferritin 85.35 ng/mL. We found good correlation between CA 15-3 and CEA correlation coeffi cient was r = 0.750. There was a low correlation between CA 15-3 and ferritin with correlation coeffi cient r = 0.274.Conclusions: The CA 15-3 and CEA are useful markers in patients with confi rmed diagnosis of breast and lung cancers. The ferritin concentration has not increased in patients with breast cancer but it increased inlung patients. The future study has to make investigations of tumor markers and ferritin in different stage of breast cancer.

  16. Zirconium molybdate hydrate precipitates in spent nuclear fuel reprocessing

    International Nuclear Information System (INIS)

    This paper presents through 2 posters a general overview studies realised by CEA teams on deposits observed in the La Hague plant dissolution facilities. Their main constituents are metallic debris bound together with zirconium molybdate hydrate. A comprehensive study of zirconium molybdate hydrate formation included nucleation and growth kinetics was developed. Fouling mechanisms were consequently explained as influenced by the operation conditions. Pu insertion was also overviewed. Its behaviour is important when curative and preventive chemical treatments are considered. (authors)

  17. A produção de anonáceas no Brasil

    Directory of Open Access Journals (Sweden)

    Eurico Eduardo Pinto de Lemos

    2014-01-01

    Full Text Available As anonáceas compõem um grupo de plantas que se têm destacado em várias partes do mundo, principalmente por produzirem frutos de grande interesse comercial. Entre os mais destacados membros desta família, estão a cherimólia (Annona cherimola, a pinha (A. squamosa, a atemoia (híbrido A. squamosa x A. cherimola, e a graviola (A. muricata. No Brasil, pelas suas características de clima tropical e com baixas altitudes na maior parte de seu território, a cherimólia tem sido pouco cultivada devido a sua exigência em temperaturas baixas. As demais apresentam áreas cultivadas em diversas regiões do País para fazer frente à demanda dos mercados de frutas frescas (pinha e atemoia e processadas (graviola. Todavia, o interesse neste grupo de plantas é mais abrangente, tendo em vista que inúmeras pesquisas comprovam que compostos secundários obtidos de várias anonáceas possuem atividade pesticida e antitumoral. Este trabalho objetiva apresentar um quadro atual da produção de anonáceas no Brasil, focando nas principais anonas cultivadas nas diferentes regiões do País. Para tanto, foram levantados dados de produção e principais tecnologias utilizadas nestas culturas. Os dados de produção obtidos serviram para estabelecer uma estimativa aproximada da realidade da produção de atemoia, pinha e graviola no Brasil. Os resultados demonstram um vigoroso crescimento na área total de cultivo, na produção e no uso de tecnologias modernas para as três espécies consideradas neste estudo. Apontam também para uma expansão dos cultivos em todas as regiões do Brasil, principalmente no Nordeste.

  18. KROTOS FCI experimental programme at CEA Cadarache: new features and status

    Energy Technology Data Exchange (ETDEWEB)

    Bonnet, J.M.; Bullado, Y.; Journeau, C.; Fouquart, P.; Piluso, P.; Sergeant, C.; Magallon, D. [CEA-Cadarache, DTN/STRI/LMA, Bat 708, BP1, 13108 Saint Paul lez Durance cedex (France)

    2005-07-01

    Full text of publication follows: KROTOS facility has been operated by the European Commission at JRC-Ispra for many years until 1999 as part of the FARO/KROTOS programme. The programme had to be stopped at JRC due to new EC priorities, and an agreement was concluded with CEA to transfer the KROTOS facility and know-how to Cadarache to continue investigating the pending FCI issues. By this agreement, CEA became owner of the facility. The main objective of the KROTOS programme at CEA Cadarache is understanding the role of melt properties in steam explosion propagation and energetics and, in particular, steam explosion behaviour of prototypical corium melts. Possible influence of physicochemical processes on explosiveness will also be explored. Actually, analysis of alumina debris produced at Ispra have shown that formation of metastable phases and chemical reaction with water at high temperature may play a significant role in enhancing heat transfer to water in the explosion phase. In order to reach the objective, steam explosion experiments are performed in well characterised conditions for a large spectrum of conditions and melt compositions of interest for both in- and ex-vessel situations. A trigger is applied as a rule. Advanced technology and instrumentation is used to reduce uncertainties on initial conditions and characterise the various phases of an explosion, with emphasis on high energy X-ray cinematography to qualify pre-mixing. This advanced instrumentation will enable the measurement of detailed variables to consolidate the qualification of the FCI codes. The use of high energy X-rays made it necessary to construct a new building to house the facility and its components. The facility should newly become operative early 2005. Main improvements with respect to Ispra concern melt delivery, hydrogen measurement and X-ray imaging. Preliminary studies have demonstrated that identification of the pre-mixture-water interface and coherent melt jet core, and

  19. Establishment of 131I, 99mTc Labeling Methods to In-house Anti-CEA Antibodies and Evaluation of the Immunological Characteristics

    International Nuclear Information System (INIS)

    Cancer cells have several tumor-associated antigens on the cell surfaces, and antibodies against these antigens have been developed by many investigators. Radiolabeled antibodies have been used as new methods to diagnose and treat malignant tumors. Especially anti-carcinoembryonic antigen (CEA) is the most popular antibody for these purposes. In this investigation, we tried to label 131I and 99mTc to anti-CEA monoclonal antibodies which were developed in the Seoul National University College of Medicine. We found CEA-79 and CEA-92 antibodies had the better immunological characteristics among 8 anti-CEA monoclonal antibodies. And radioiodination of CEA-79 could be performed by chloramine-T method, while radioiodination of CEA-92 by iodogen method. To label these antibodies with 99mTc, we used pretargeting transchelation as direct labeling method. At first, 99mTc was bound to glucaric acid, and monoclonal antibody was reduced by β-mercaptoethanol. When these were incubated together, 99mTc bound to glucarate was switched to monoclonal antibody because of higher affinity. We established conditions of several steps in this method. Anti-CEA monoclonal antibodies labeled with 131I and 99mTc are expected to be used valuably in the detection and treatment of malignant tumors.

  20. Serum tetranectin is an independent prognostic marker in colorectal cancer and weakly correlated with plasma suPAR, plasma PAI-1 and serum CEA

    DEFF Research Database (Denmark)

    Høgdall, Claus K; Christensen, Ib J; Stephens, Ross W;

    2002-01-01

    activator (uPAR) and carcinoembryonic antigen (CEA). Significantly shorter survival was found for patients with TN levels below a cut-off point of 7.5 mg/l compared to patients with levels above, as illustrated by Kaplan-Meier curves. By Cox analyses, log TN, log soluble uPAR as well as log CEA were found...

  1. Proceedings of the 1989 CESAR/CEA (Center for Engineering Systems Advanced Research/Commissariat a l'Energie Atomique) workshop on autonomous mobile robots (May 30--June 1, 1989)

    Energy Technology Data Exchange (ETDEWEB)

    Harber, K.S.; Pin, F.G. (Oak Ridge National Lab., TN (USA). Center for Engineering Systems Advanced Research)

    1990-03-01

    The US DOE Center for Engineering Systems Advanced Research (CESAR) at the Oak Ridge National Laboratory (ORNL) and the Commissariat a l'Energie Atomique's (CEA) Office de Robotique et Productique within the Directorat a la Valorization are working toward a long-term cooperative agreement and relationship in the area of Intelligent Systems Research (ISR). This report presents the proceedings of the first CESAR/CEA Workshop on Autonomous Mobile Robots which took place at ORNL on May 30, 31 and June 1, 1989. The purpose of the workshop was to present and discuss methodologies and algorithms under development at the two facilities in the area of perception and navigation for autonomous mobile robots in unstructured environments. Experimental demonstration of the algorithms and comparison of some of their features were proposed to take place within the framework of a previously mutually agreed-upon demonstration scenario or base-case.'' The base-case scenario described in detail in Appendix A, involved autonomous navigation by the robot in an a priori unknown environment with dynamic obstacles, in order to reach a predetermined goal. From the intermediate goal location, the robot had to search for and locate a control panel, move toward it, and dock in front of the panel face. The CESAR demonstration was successfully accomplished using the HERMIES-IIB robot while subsets of the CEA demonstration performed using the ARES robot simulation and animation system were presented. The first session of the workshop focused on these experimental demonstrations and on the needs and considerations for establishing benchmarks'' for testing autonomous robot control algorithms.

  2. Report on nuclear safety and transparency 2011 - Fontenay-aux-Roses CEA centre

    International Nuclear Information System (INIS)

    After a brief presentation of the Fontenay-aux-Roses CEA centre, this report indicates the different safety measures in the different nuclear base installations (INB) of this site (measures related to different risks, to emergency situations, to inspections and audits). It describes measures related to radiation protection: organisation, dosimetry results. It presents the different significant events which occurred in 2011 and were declared to the ASN. It discusses the results of measurements of liquid, gaseous and chemical releases from the installations and their impact on the environment. It addresses the radioactive waste management (measures to limit their volume and to limit their impact on health and on the environment, notably on water and soils, type and quantities of wastes stored in INBs). It presents the different measures and actions related to information transparency

  3. Introduction to Cea studies on future nuclear energy systems and safety related research

    International Nuclear Information System (INIS)

    The growth in world energy demand and future prospects of decommissioning of existing power plants stimulate the development of a new generation of nuclear energy systems intended to be more economical, safer and more sustainable. CEA clearly support the idea that nuclear energy has unique assets to be eligible as one of the major energy sources of the sustainable development in terms of natural resources saving, economic competitiveness and public and environmental friendliness, but the possibility of development of nuclear energy is strongly linked with the public acceptance. Public acceptance of nuclear energy depends strongly on safety, and the publics perception of safety. Consequently, a major emphasis for future generations nuclear systems is to improve the safety and the robustness of the technology, and thus the public confidence in safety. (authors)

  4. Incineration as a radioactive waste volume reduction process for CEA nuclear centers

    International Nuclear Information System (INIS)

    Incineration processes represent a promising solution for waste volume reduction, and will be increasingly used in the future. The features and performance specifications of low-level waste incinerators with capacities ranging from 10 to 20 kg-h-1 at the Fontenay-aux-Roses, Grenoble and Cadarache nuclear centers in France are briefly reviewed. More extensive knowledge of low-level wastes produced in facilities operated by the Commissariat a l'Energie Atomique (CEA) has allowed us to assess the volume reduction obtained by processing combustible waste in existing incinerators. Research and development work is in progress to improve management procedures for higher-level waste and to build facilities capable of incinerating α - contaminated waste. (authors). 6 refs., 5 figs., 1 tab

  5. Release monitoring and environmental surveillance of Cea centers. Assessment and regulation and method 1999

    International Nuclear Information System (INIS)

    The quality of the natural environment around the centers of the Commissariat a l Energie Atomique is an important point of its safety policy. The environmental protection is based on the control of risks coming from research and development activities of its installations. It aims to reduce as low as possible, the impact of its activities on man and his environment. This publication develops the sampling and measurement methods that are made on effluents and in environment, according to the radionuclides characteristics, that are present. It gives also the regulation that applied to the effluents monitoring. The results of radioactive effluents releases (liquid and gaseous) and the surveillance of environment around cea centers is given in the 'Bilan 1999' publication. An analysis of these results on the 1995-1999 period allows to follow their evolution. (N.C.)

  6. New high density MTR fuel. The CEA-CERCA-COGEMA development program

    International Nuclear Information System (INIS)

    The development of a new generation of LEU, high in density and with reprocessing capacities MTR fuel, is a key issue to provide reactor operators with a smooth operation which is necessary for a long term development of Nuclear Energy. In the RRFM'98 meeting, a joint contribution of CEA, CERCA and COGEMA presented a technical classification of the potential candidates uranium alloys. In this paper this MTR working group presents the development program of a new high density fuel. This program is composed of three main steps: Basic Data analysis and collection, Plate Tests (Irradiation and Post Irradiation Examinations) and Lead Test Assemblies (Irradiation and Post Irradiation Examinations). The goal to be reached is to make this new fuel available before the end of the present US return policy. (author)

  7. GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)

    CERN Document Server

    Schapira, J P

    1999-01-01

    Nuclear waste partitioning and transmutation (P and T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON (GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented.

  8. GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)

    International Nuclear Information System (INIS)

    Nuclear waste partitioning and transmutation (P and T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON (GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented

  9. GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)

    Science.gov (United States)

    Schapira, J. P.

    1999-07-01

    Nuclear waste partitionning and transmutation (P & T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON ( GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented.

  10. Cea-DSM-DAPNIA-SACM contribution to IFMIF KEP phase June 2000 to December 2002

    International Nuclear Information System (INIS)

    The international fusion materials irradiation facility (IFMIF) requires the generation by a linear accelerator (LINAC) of 250 mA continuous current of deuterons at a nominal energy of 40 MeV. The basic approach is to provide 2 linac modules, each delivering 125 mA to a common target. The accelerators begin with a deuteron ion source and a low-energy beam transport to a radio-frequency quadrupole (RFQ), a buncher and a pre-accelerator up to 5 MeV. The key element technology phase (KEP) was initiated in 2000 with the objective of reducing some key technology risk factors. The IFMIF KEP is carried out at the Cea and it focuses on 5 issues: the ECR source, the 4-vanes RFQ design, the radio-frequency system, the DTL (drift tube linac) design, and high power diagnostics. The present report reviews progress made in the 5 issues quoted above. (A.C.)

  11. The French approach through the SMR consortium (CEA, EDF, AREVA, DCNS)

    International Nuclear Information System (INIS)

    The SMR (Small Modular Reactor) is a new range of nuclear reactors characterized by a low output power (less than 300 MWe) and a standardized modular factory-based construction. Moderate capital costs make this type of reactor very attractive for medium-size power utilities or small countries. A consortium made around the CEA and its industrial partners (EDF, AREVA and DCNS) has performed economic and technical feasibility studies. It appears that the competitiveness of SMR require power production costs around 100 euros/MWh and that SMR will be based on PWR technology with a power output of 150 MWe per unit. 2 types of SMR are proposed: a terrestrial unit and an immersed unit. The concept of the immersed SMR, called Flexblue, is based on an unlimited access to a cold sink (the ocean) and a complete modularity. In both types the standard of safety appears to be high. (A.C.)

  12. Microflora de Bromeliáceas do estado de Pernambuco, Brasil

    Directory of Open Access Journals (Sweden)

    Luis Tavares de Lyra

    1976-01-01

    Full Text Available O autor estudou a microflora de dois gêneros de BROMELIACEAE: Hoenbergia e Portea. As coletas do material foram feitas em seis regiões do Estado de Pernambuco; 1 Região da Mata-Úmida; 2 Região da Mata-Seca; 3 Região do Agreste Central; 4 Região do Agreste Setentrional; 5 Região do Agreste Meridional; 6 Região do Recife. As seguintes diatomáceas indicadoras de águas poluídas (espécies oligossaprobias foram encontradas nas seis regiões estudadas: Gomphonema parvulum (Kutz Grunow., Hantzschia amphioxys Grunow, Pinnularia borealis Ehr., Pinnularia microstauron (Ehr Cleve, gomphonema gracile Ehr., Nitzschia palea Kutz., Melosira roeseana Rabenh., Navicula mutica Kutz., Navicula cryptocephala Kutz., Eunotia pectinalis (Kutz Rabenh. Foram também observadas CHLOROPHYCEAS nas estações chuvosa e seca nas diversas regiões. Algumas são indicadoras de oligossaprobidade: Scenedesmus quadricauda (Turpin brebisson. Chlorococcum sp., Chlorella sp. Os fatores ecológicos e comentários referentes ás diatomáceas foram anotados no texto. A tabela I indica a frequência das diatomáceas nas seis regiões estudadas. Maior número dessas diatomáceas, registramos nas regiões do Agreste. A tabela II mostra a temperatura e pH da água de Hoenbergia e Portea em ambas as estações do ano (inverno e verão. Observamos a ocorrência de larvas de culex em Portea e hoenbergia, entretanto, raramente encontramos larvas de Anopheles. As coletas foram feitas durante as estações chuvosa e seca em Hoenbergia e Portea. Determinamos 35 espécies provenientes de 78 amostras coletadas durante o período de 26 meses.The author studied the microflora from two genera of Bromeliaceae: Hoenbergia and Portea. The material was collected in six natural regions of Pernambuco State: 1 Humid Forest Region; 2 Dry forest region; 3 Central Agreste Region; 4 Setentrional Agreste Region; 5 Meridional Agreste Region; 6 Recife Region. The following diatoms that indicate polluted

  13. Cea-DSM-DAPNIA-SACM contribution to IFMIF KEP phase June 2000 to December 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-05-01

    The international fusion materials irradiation facility (IFMIF) requires the generation by a linear accelerator (LINAC) of 250 mA continuous current of deuterons at a nominal energy of 40 MeV. The basic approach is to provide 2 linac modules, each delivering 125 mA to a common target. The accelerators begin with a deuteron ion source and a low-energy beam transport to a radio-frequency quadrupole (RFQ), a buncher and a pre-accelerator up to 5 MeV. The key element technology phase (KEP) was initiated in 2000 with the objective of reducing some key technology risk factors. The IFMIF KEP is carried out at the Cea and it focuses on 5 issues: the ECR source, the 4-vanes RFQ design, the radio-frequency system, the DTL (drift tube linac) design, and high power diagnostics. The present report reviews progress made in the 5 issues quoted above. (A.C.)

  14. List of reports concerning reactor safety research of BMFT, CEA, EPRI, JSTA and USNRC

    International Nuclear Information System (INIS)

    This list reviews reports from the Federal Republic of Germany, from France, from Japan and from the United States of America concerning special Problems in the field of Reactor Safety Research. According to the cooperation of the Bundesminister fuer Forschung und Technologie (BMFT) with the Commissariat a l' Energie Atomique (CEA), the Japan Science and Technology Agency (JSTA), the Electric Power Research Institute (EPRI) and the United States Nuclear Regulatory Commission, these Reports are available in the Gesellschaft fuer Reaktorsicherheit (GRS). The list pursues the following order: Country of origin, problem area concerned, according to the Reactor Safety Research Programm of the BMFT, reporting organization. The list of reports appears quarterly. (orig./HP)

  15. New high density MTR fuel. The CEA-CERCA-COGEMA development program

    Energy Technology Data Exchange (ETDEWEB)

    Languille, A. [CEA/DEC Centre de Cadarache, St. Paul lez Durance (France); Durand, J.P. [CEDRCA, ZI les Berauds, Romans (France); Gay, A. [COGEMA/BCR, St. Quentin en Yvelines (France)

    1999-07-01

    The development of a new generation of LEU, high in density and with reprocessing capacities MTR fuel, is a key issue to provide reactor operators with a smooth operation which is necessary for a long term development of Nuclear Energy. In the RRFM'98 meeting, a joint contribution of CEA, CERCA and COGEMA presented a technical classification of the potential candidates uranium alloys. In this paper this MTR working group presents the development program of a new high density fuel. This program is composed of three main steps: Basic Data analysis and collection, Plate Tests (Irradiation and Post Irradiation Examinations) and Lead Test Assemblies (Irradiation and Post Irradiation Examinations). The goal to be reached is to make this new fuel available before the end of the present US return policy. (author)

  16. Overview of CEA studies on advanced Plutonium fuelled PWR core concepts

    International Nuclear Information System (INIS)

    After a brief summary of the French experience of Plutonium recycle in PWRs and a review of the rationale for this strategy, a first part of the paper presents the plans for generalizing the recycling of 30% MOX in present generating facilities and the next generation reactors (EPR). A second part of the paper is dedicated to an overview of CEA studies on advanced 100% MOX PWR core concepts compatible with the EPR design and likely to improve the performances of the reference core design in terms of Plutonium consumption, and minor actinides production. The respective merits of these advanced 100% MOX PWR core concepts are briefly summarized, as well as their potential benefits to accommodate a wide variety of future options for the fuel cycle. (author) 3 figs., 6 tabs., 11 refs

  17. Status of the CNES-CEA joint program on space nuclear Brayton systems

    International Nuclear Information System (INIS)

    A Cooperative program between the French Centre National d'Etudes Spatiales (CNES) and the Commissariat a l'Engergie Atomique (CEA) was initiated in 1983, to investigate the possible development of 20 to 200 kWe space nuclear power systems to be launched by the next version of the European launcher, Ariane V. After completion in 1986 of preliminary conceptual studies of a reference 200 kWe turboelectric power system, an additional 3 year study phase was decided, with the double objective of assessing the potential advantage of nuclear power systems versus solar photovoltaic or dynamic systems in the 20 kWe power range, and comparing various reactor candidate technologies and systems options for 20 kWe space nuclear power systems, likely to meet the projected energy needs of future European space missions. The results of this study are discussed by the authors

  18. TRIPOLI-4®, CEA, EDF and AREVA Reference Monte Carlo Code

    Science.gov (United States)

    2014-06-01

    This paper presents an overview of TRIPOLI-4®, the fourth generation of the 3D continuous-energy Monte Carlo code developed by the Service d'Etudes des Réacteurs et de Mathématiques Appliquées (SERMA) at CEA Saclay. The paper surveys the generic features: programming language, parallel operation, tracked particles, nuclear data, geometry, simulation modes, standard variance reduction techniques, sources, tracking and collision algorithms, tallies, sensitivity studies. Moreover, specific and recent features are also detailed: Doppler broadening of the elastic scattering kernel, neutron and photon material irradiation, advanced variance reduction techniques, Green's functions, cycle correlation correction, nuclear data management and depletion capabilities. The productivity tools (T4G, SALOME TRIPOLI, T4RootTools), the Verification & Validation process and the distribution and licensing policy are finally presented.

  19. The CEA-FRAGEMA ramp test programme for the experimental study of PCI

    International Nuclear Information System (INIS)

    The first phase of the CEA-FRAGEMA ramp test programme which started in 1977 is now terminated. More than twenty-seven fuel rods of PWR type have been ramp tested. Two types of CEA fuel rod design were selected, rods of diameter equal to 8.70 mm with stress relieved Zircaloy 4 claddings and UO2 DCN pellets, rod of diameter typical to 17x17 assembly with recristallysed Zircaloy 4 claddings and UO2 DCI pellets. Except a group of six rods pressurized with 35 bar of Helium, all the rods were pressurized with 1 bar of helium, all the rods were base-irradiated in the BR3 reactor. The burnup ranges are lying between 8 GWd tU-1 and 45 GWd tU-1. An important goal of this programme was also to qualify the FABRICE process which consists in the refabrication of short length rods cut-out from long rods and whose performance during ramp tets have been compared with those of spare rods. The behaviour was quite similar and thus allows to test short rods cut-out from long fuel rods which have been base-irradiated in PWR commercial reactors such as Fessenheim, Bugey or CAP. After recalling the main characteristics of the ramp tested fuel rods and the irradiation conditions the paper presents an overview of the ramp test results and emphasizes the results obtained by Eddy Current tests and confirmed by metallographic examinations which lead to define an interaction zone expressed in terms of local linear heat rating, and burnup. The SCC was found to be the governing phenomenon which led to PCI failures. The influence of burnup, maximum linear heat-rating, initial power or power step is demonstrated, the influence of initial internal pressurization is established at least at burnup greater than 40 GWd tU-1. PCI failure thresholds are established and compared with other limits given in the open literature. (author)

  20. Overview of CEA studies on hydrogen production and related prospects for nuclear power

    International Nuclear Information System (INIS)

    The anticipated growth of the world energy demand and the increasing concern about the emission of greenhouse gases, with the objectives of limitation fixed by the Kyoto protocol, prepare the ground for the development of hydrogenous fuels, and especially that of hydrogen as energy carrier. The trend will be reinforced in the longer term with the progressive shortage of natural hydrocarbon fuels. Fuel cells used in stationary, transport and portable applications will probably be the most efficient hydrogen converter and the most promising decentralized energy technology of the next decades. In order to contribute to the reduction of greenhouse gas emissions, a massive use of hydrogen for transport and stationary applications calls for the development of production processes compatible with low CO2 emissions, thus limiting the use of fossil fuels (natural gas, oil, coal...) as reagent or energy sources. Furthermore, the progressive exhaustion of economic fossil fuel reserves will ultimately make it necessary to extract hydrogen from water through CO2 free processes. With this prospect in view, base-load nuclear energy, besides renewable energies, can play an important role to produce hydrogen through electrolysis in the medium term, and also through high temperature thermochemical water dissociation processes in the longer term. Starting from current research in the field of fuel cans and hydrogen storage systems, the CEA intends to implement a large R and D programme on hydrogen also covering the aspects of production, transport and related safety requirements. This endeavour is intended to reinforce the contribution of the CEA to the national and European research effort on non-fossil energy sources, and to open new opportunities of international collaborations and networking. (authors)

  1. Immunoscintigraphy of CEA-expressing cancers with complete and fragmented monoclonal antibodies: indications, chances and limits

    International Nuclear Information System (INIS)

    CEA-expressing cancers belong to the most frequent malignant diseases of the western world. The early recognition of tumor recurrence or metastasis, respectively, is probably the key to an improvement of the patient's prognosis. Conventional radiological procedures are characterized by their limited sensitivity and specificity; therefore, complementary methods, such as immunoscintigraphy, are warranted. In Europe, essentially three monoclonal anti-CEA antibodies, which can be directly labeled with technetium (complete IgG of the clone BW431/26, as well as the fragments F023C5 and IMMU-4), are in clinical use. Complete IgG is burdened by slow tumor targeting kinetics and a slow background clearance. This makes its diagnostic use with short-lived isotopes difficult. Fragments are able to targert more quickly but express some metabolic instability, as well as a high renal accretion. Fragments have shown higher sensitivities in the detection of liver metastases and local recurrences, two of the most important sites of tumor relapse. In contrast to IgG, diagnosis is usually possible as early as after 4-6 h p.i. Thus, different indications for the use of IgG or fragments result, and, in the individual case, also complementary studies with both may be indicated. Whereas 30% of patients develop HAMA after a single administration of IgG, the HAMA incidence of fragments is, with less than 1%, dramatically lower, even in the case of repeated administrations. Future studies with humanized antibodies, smaller 'molecular recognition units', or the development of stable bivalent fragment with technetium label will show whether further improvements of the diagnostic accuracy are possible. (orig.)

  2. Gnatophyma: a rare form of rosacea Gnatofima: uma forma rara de rosácea

    Directory of Open Access Journals (Sweden)

    Ana Carolina Lisboa de Macedo

    2012-12-01

    Full Text Available Phyma is the last stage of rosacea and is due to chronic inflammation and edema. It can affect nose (rhinophyma, chin (gnatophyma, forehead (metophyma, ears (otophyma and eyelids (blepharophyma. Rhinophyma is the most frequent location and there are few reports about gnatophyma. We report the case of a female patient, 41 years old, who had an infiltrated, erythematous, edematous plaque around the chin and lower lip for two years. Histopathology showed perivascular lymphocytic infiltrate, hypertrophied follicles and sebaceous glands, dilated vessels and fibrosis. She was treated with oral tetracycline, oral ivermectin and metronidazole cream with a satisfactory response. The clinical, histopathological and therapeutic response correlation confirmed the diagnosis of gnatophyma, a rare variant of phyma.Fima é o estágio final da rosácea e ocorre devido ao edema e inflamação crônica. Pode acometer nariz (rinofima, mento (gnatofima, fronte (metofima, orelhas (otofima e pálpebras (blefarofima. Rinofima é a localização mais encontrada e há raros relatos de gnatofima. Relataremos paciente feminina, 41 anos, que apresentava placa infiltrada, eritêmato-edematosa, em todo o mento e lábio inferior há dois anos. Histopatológico com infiltrado linfocitário perianexial e perivascular, folículos e glândulas sebáceas hipertrofiadas, vasos ectasiados e fibrose perianexial. Foi instituído tratamento com tetraciclina via oral, ivermectina via oral e metronidazol creme com resposta satisfatória. Através da correlação clínica, histopatológica e resposta terapêutica confirmou-se o diagnóstico da variante rara de fima, gnatofima.

  3. Annual report of the Association EURATOM/CEA 2003 (executive summary)

    International Nuclear Information System (INIS)

    3 different materials (copper base, stainless steel and mono-crystalline molybdenum) have been selected for mirrors used in diagnostic purposes. A new diagnostic for thermographic analysis has been developed for JET. The EURATOM-Cea association is involved in the development of the first ITER neutral beam injector (in particular the source and the accelerator) and in the design of the ITER neutral beam test facility. The EURATOM-Cea association has contributed to the design of an ITER-relevant ICRH launcher that will be installed on JET during the 2004 shutdown. The development of an industrial cutting and welding laser tool for fabrication and maintenance of hydraulic connector parts of the ITER blanket module has been achieved in 2003. Work on the manufacture of the ITER primary first wall panel by HIP forming is ongoing. In the field 'plasma facing components' activities have focused on flat tile technology and particularly on the possibility of failure in cascade of these tiles. A full-scale prototype mock-up of the ITER divertor vertical target has been high flux tested. The hot isostatic pressing technique has been selected for the fabrication of lot of fusion reactor components. Concerning remote handling activities, the feasibility studies for the remote maintenance (cutting, welding and inspection) of the ITER divertor cooling pipe with bore tools have been achieved. In the field 'magnet', activities have focused on an extensive characterization of 3 types of NbTi strand candidate for ITER PF coils and on the thermohydraulic properties of cable-in-conduit conductors. The helium cooled lithium lead (HCLL) breeding blanket concept has been developed for the test blanket module. In the field 'structural materials', work has been dedicated to the development of reduced activation ferritic martensitic steel and of SiC-SiC ceramic composites and of tungsten alloys. In the framework of fusion waste management, different processes that could be used for tritium

  4. 3-month GPS subsidence analysis in North Sea, ELF/CEA-LDG interpretation

    International Nuclear Information System (INIS)

    The authors process and analyze 3 months of continuous GPS offshore data provided by the operator from 10 single-frequency stations in the Ekofisk field in the north Sea for subsidence monitoring. This analysis is done using the Differential-GPS automatic software and method developed by the EAP/CEA-LDG. The mean subsidence rates obtained by the EAP/CEA method shows, over these three months, a maximum rate at the center of the subsidence of about 30 mm/month bowl in agreement with previous determinations. The accuracy of the results can be improved by smoothing techniques. However, the noise is still directly related to the distance between the monitored point and the reference points. For instance, the daily averages lead to an accuracy (root mean squares = r.m.s) of 1.1, 1.4 and 2.4 mm for the East, North and Vertical components of the movements for a 2 km baseline and 1.8, 3.7 and 3.8 mm for the East, North and Vertical components for a 24 km baseline. The choice of the best reference points in the network is discussed. Horizontal measurements are simultaneously detected and may be due either to platform tilt or to sea-bed horizontal movements. A further analysis (the 2-hours method) indicate that the noise in the results has a periodic daily structure. In addition, results from previous calibration experiments are used in the method to test the result quality, processed data interpretation

  5. Perioperative cerebral ischemic complications after carotid endarterectomy without shunting. A series of 400 consecutive CEA evaluated by intraoperative monitoring and post-operative diffusion-weighted imaging

    International Nuclear Information System (INIS)

    The use of intraluminal shunting during carotid endarterectomy (CEA) remains controversial. From January 2001 to September 2010, 400 CEAs without shunting were performed under general anesthesia by 14 neurosurgeons (2 consultants, 12 trainees). We used electroencephalography (EEG) and somatosensory evoked potential (SEP) to monitor under selective burst suppression using barbiturate or propofol administration during cross-clamping. In 66 of the 400 CEAs (16.5%), intraoperative monitoring demonstrated abnormalities after cross-clamping. In 26 (6.5%) of the 400 CEAs, new areas of diffusion hyperintensity were identified postoperatively. Within 30 days, the combined mortality and morbidity (symptomatic ischemia) rate was 2.8%. Thirteen (3.3%) patients presented with TIA. CEA without shunting can be safely performed with EEG and SEP monitoring under induced hypertention and selective burst suppression. (author)

  6. Localization of 131Ilabeled goat and primate anti-carcinoembryonic antigen(CEA) antibodies in patients with cancer

    International Nuclear Information System (INIS)

    Thirty patients with anti-carcinoembryonic antigen (CEA)-producing cancers of the colon, breast, or thyroid were intected with 1 to 2 mCi of Iodine-131 (131I)-labeled, affinity-purified, goat or baboon anti-CEA antibodies. Images were obtained daily for four days. Computerized background subtraction using technetium 99m (99mTC)-labeled compounds was used. Images obtained with and without background subtraction were correlated with other evidence of disease. Activity levels in plasma, urine, and thyroid gland were monitored. Significant deiodination of antibody occurred within the first 24 hours. The mean plasma half-disappearance-time of baboon antibody was significantly longer than the mean half-disappearance-time of goat antibody. With exogenous blockade, total thyroid uptake was less than 0.1% of the injected dose. Without background subtraction, scintigraphic localization of known tumor was possible in one of two patients with colon carcinoma, in three of 20 patients with breast cancer, and in one of five patients with medullary carcinoma of the thyroid. With background subtraction, potential false-positive results could be generated for every patients, depending on the normalization site chosen and the degree of subtraction used. In contrast to results of previous reports, CEA-producing tumor was found to be infrequently localized using highly purified goat or primate radiolabeled anti-CEA. Furthermore, the subtraction technique described by previous investigators may lead to a high false-positive rate

  7. Etude de la diffusion du carbone dans le zirconium et la zircone en volume des gaines de combustible usées par simulations multi-échelles

    OpenAIRE

    Xu, Yu

    2015-01-01

    As part of the nuclear waste management, hulls and ends of fuel claddings are cut, compacted and put in CSD-C containers (compacted standard waste containers). Currently stored at La Hague, the waste will be stored in deep geological environment. The MA-VL waste contains RN including carbon-14, which comes from the neutron activation of nitrogen-14 and oxygen-17 present in the oxide Zircaloy. The objective of this thesis, which is taken in collaboration with EDF and AREVA, is to answer the qu...

  8. Serum tumor marker CYFRA 21-1 in the diagnostics of squamous cell lung cancer - comparison with CEA

    International Nuclear Information System (INIS)

    The aim of the study was to test the diagnostic value tumor marker CYFRA 21-1 for squamous cell lung cancer (SQCLC) in comparison with carcinoembryonic antigen (CEA). Ninety-one patients were induced in this study: 56 with SQCLC - Group I, 25 with other types of lung cancer - Group II, 10 with benign respiratory tract diseases - Group III. Median CYFRA 21-1 serum concentration (ng/ml) was: in Group I: 4.52 (0.94 - >16), in Group II: 3.58 (1.72 - >16), in Group III: 2.05 (0.99 - 3.41). Median CEA serum concentration (ng/ml) was: in Group I: 4.49 (076- >20), in Group II: 3.32 (1.17 - >20), in Group III: 3.09 (1.84 - 6.37). There was a highly significant difference between the levels of CYFRA 21-1 in group I and Group III (p < 0.001), but there was no statistically significant difference between the levels of CEA in Group I and III. Sensitivity of CYFRA 21-1 by the cut-off 3.33 ng/ml in the diagnostics of SQCLC was 0.68, specificity 0.090, positive predictive value 0.91, negative predictive value 0.65. Sensitivity of CEA by cut-off 4.61 ng/ml was 0.5 by the same specificity 0.90. CYFRA 21-1 has high sensitivity, specificity and positive predictive value in the diagnostics of SQCLC. Sensitivity of CYFRA 21-1 is significantly higher than sensitivity of CEA in this settings. (author)

  9. A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma

    International Nuclear Information System (INIS)

    Objectives: To assess the prognostic value of combined evaluation of preoperative CT findings and pre/postoperative serum carcinoembryonic antigen (CEA) levels for pathological stage I lung adenocarcinoma. Methods: This retrospective study included 250 consecutive patients who underwent complete resection for ≤3-cm pathological stage I (T1–2aN0M0) adenocarcinomas (132 men, 118 women; mean age, 67.8 years). Radiologists evaluated following CT findings: maximum tumor diameter, percentage of solid component (%solid), air bronchogram, spiculation, adjacency of bullae or interstitial pneumonia (IP) around the tumor, notch, and pleural indent. These CT findings, pre/postoperative CEA levels, age, gender, and Brinkman index were assessed by Cox proportional hazards model to determine the best prognostic model. Prognostic accuracy was examined using the area under the receiver operating characteristic curve (AUC). Results: Median follow-up period was 73.2 months. In multivariate analysis, high %solid, adjacency of bullae or IP around the tumor, and high postoperative CEA levels comprised the best combination for predicting recurrence (P < 0.05). A combination of these three findings had a greater accuracy in predicting 5-year disease-free survival than did %solid alone (AUC = 0.853 versus 0.792; P = 0.023), with a sensitivity of 85.7% and a specificity of 74.3% at the optimal threshold. The best cut-off values of %solid and postoperative CEA levels for predicting high-risk patients were ≥48% and ≥3.7 ng/mL, respectively. Conclusion: Compared to %solid alone, combined evaluation of %solid, adjacency of bullae or IP change around the tumor, and postoperative CEA levels improves recurrence prediction for stage I lung adenocarcinoma

  10. A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Yamazaki, Motohiko, E-mail: xackey2001@gmail.com [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Ishikawa, Hiroyuki [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Kunii, Ryosuke [Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Tasaki, Akiko; Sato, Suguru; Ikeda, Yohei; Yoshimura, Norihiko [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Hashimoto, Takehisa; Tsuchida, Masanori [Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences (Japan); Aoyama, Hidefumi [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan)

    2015-01-15

    Objectives: To assess the prognostic value of combined evaluation of preoperative CT findings and pre/postoperative serum carcinoembryonic antigen (CEA) levels for pathological stage I lung adenocarcinoma. Methods: This retrospective study included 250 consecutive patients who underwent complete resection for ≤3-cm pathological stage I (T1–2aN0M0) adenocarcinomas (132 men, 118 women; mean age, 67.8 years). Radiologists evaluated following CT findings: maximum tumor diameter, percentage of solid component (%solid), air bronchogram, spiculation, adjacency of bullae or interstitial pneumonia (IP) around the tumor, notch, and pleural indent. These CT findings, pre/postoperative CEA levels, age, gender, and Brinkman index were assessed by Cox proportional hazards model to determine the best prognostic model. Prognostic accuracy was examined using the area under the receiver operating characteristic curve (AUC). Results: Median follow-up period was 73.2 months. In multivariate analysis, high %solid, adjacency of bullae or IP around the tumor, and high postoperative CEA levels comprised the best combination for predicting recurrence (P < 0.05). A combination of these three findings had a greater accuracy in predicting 5-year disease-free survival than did %solid alone (AUC = 0.853 versus 0.792; P = 0.023), with a sensitivity of 85.7% and a specificity of 74.3% at the optimal threshold. The best cut-off values of %solid and postoperative CEA levels for predicting high-risk patients were ≥48% and ≥3.7 ng/mL, respectively. Conclusion: Compared to %solid alone, combined evaluation of %solid, adjacency of bullae or IP change around the tumor, and postoperative CEA levels improves recurrence prediction for stage I lung adenocarcinoma.

  11. Requerimiento de nitrógeno en la producción de Stevia rebaudiana Bertoni en hidroponía e invernadero.

    OpenAIRE

    Salgado Cordero, Luz Eréndira

    2014-01-01

    La Stevia rebaudiana, también llamada hierba dulce o Ka’a-He’e, es una herbácea semiperenne de la flora paraguaya perteneciente a la familia Asteraceae. La estevia es empleada por la industria alimentaria y farmacéutica debido a compuestos glucósidos que se obtienen a partir de la hoja, los cuales tienen un poder edulcorante hasta 250 a 300 veces mayor a la de la sacarosa. La presente investigación se realizó con el objetivo de evaluar el efecto de diferentes niveles de nitrato sobre la produ...

  12. Technical report on the fatigue crack Growth Benchmark based on CEA pipe bending tests

    International Nuclear Information System (INIS)

    In order to improve the estimation methods of surface crack propagation through the thickness of components, CEA has proposed a benchmark to members of the IAGE WG, sub-group on Integrity of metal components and structures. The subject is a simple configuration of a pipe containing an axisymmetric notch and submitted to a cyclic bending load. An experimental data-set form CEA was used to validate three issues in the topic of Leak Before Break. - Crack initiation, - Crack propagation through the thickness, - Crack penetration. All material and geometrical data which are necessary for the simulation were given in the proposal, including experimental results. Due to the peculiar complexity of the problem, it was decided to focus the work on methodologies comparison so as to allow participants to tune up parameters and adjust their models and tools. This report presents all estimations performed by the participants and collected by CEA. They are compared to the experimental results. An analysis of the used procedures is also proposed. This, associated with the study of the accuracy of different methodologies, leads to comments and recommendations on the analysis of fatigue crack growth. The participation in the first step was important: nine participants have proposed analyses, sometimes parametric analysis to estimate crack growth. Results sorted out three estimation methods groups that give results in accordance with experimental ones (these three groups are based on a strain range evaluation and the fatigue curve of the material): - The use of an elastic stress at the notch tip and a fatigue notch concentration factor to determine the strain range. - The use of a KI (or elastic F.E. calculation) and a Neuber rule for the estimation of the strain range at a characteristic distance from the crack tip. - The direct calculation of the strain range at the characteristic distance by an elastic plastic F.E. calculation. Only 4 participants have proposed an estimate of the

  13. Nuclear energy for the future: CEA strategic R and D orientations

    International Nuclear Information System (INIS)

    Worldwide energy consumption is expected to double over the next 50 years. If there is no major change in the trend, this growth should quickly cause depletion of fossil fuel resources, a dramatic increase in the contents of greenhouse effect gases and a serious supply risk for many countries. Beyond energy savings and the development of renewable energies, nuclear energy can provide a sustainable solution to these increased needs. This is the context in which the CEA is developing its nuclear R and D strategy for the future. One objective is to optimize and develop the current nuclear facilities : R and D for nuclear energy should increase the competitiveness of existing nuclear facilities, further improve safety. Water reactors (PWR and BWR), based on design principles that are now almost 40 years old, have been improved over time, but also made more complex due to increasing safety requirements, and more powerful through economic optimization. Enriched uranium fuels are safe and reliable. Pressurized water reactors are expected to become even more competitive in time with the new reactor designs (EPR) and the life extension of existing power stations. Nuclear energy sustainable development will only succeed with public acceptance. Solutions to Plutonium inventory management (see paper nr. 665) must be provided by either using it in fast neutron reactor where it as the most energy production efficiency or burning it out in existing - or future - PWR. Another objective is to bring efficient and acceptable solutions for HLLL waste management (see paper nr. 666) and reinforce knowledge on health and environment impact of nuclear activities. The third objective is to prepare and assess new generations of nuclear energy systems. Water reactors only consume 1% of the initial natural uranium and irradiated fuels still contain 96% of energetic material ; they also have a limited turbine efficiency. Industrial fast neutron reactors have been built. These reactors have

  14. Experimental study of biotin-avidin pretargeting technique for anti-CEA McAb radioimmunoimaging

    International Nuclear Information System (INIS)

    Biotin-avidin pretargeting technique was used in promoting the diagnostic efficacy of anti-CEA McAb radioimmunoimaging. CEA McAb was conjugated with biotin McAb (B-McAb), streptavidin (SA) was labeled with 131I (131I-SA) and DTPA-biotin with 111In(111In-DTPA-B). Experimental human colonic tumor bearing nude mice were used. Two step method: B-McAb was preinjected, followed by 131I SA 48h later, 24, 48, 96 and 120 h postinjection, γ-imaging and biodistribution were studied. Three step method: B-McAb was preinjected, followed by cold SA 24h later and 111In-DTPA-B another 24h later. 2,6,24 and 48h postinjection, γ-imaging and biodistribution were also studied. Two step method: T/NT of all organs in experimental group was significantly increased compared with controls. The blood T/NT in experimental group and control group at 24 and 120h was 1.11:0.42 and 8.58:3.51, respectively. Tumor % ID/g in all organs slightly decreased compared with direct group. In γ-imaging radioactivity has been accumulated in tumor site as early as 24h, while only slightly visualized or non-visualized in controls. Three step method: in experimental group the blood T/NT reached 4.19 at 2 h, whereas all was < 1.37 at each phase of controls, the T/NT of all organs was also higher in experimental grouped than in controls. The tumor % ID/g in experimental group was 9.72% at 2h and 3.65% at 48h whereas % ID/g in controls in all phases was <3.07. The tumor clearly visualized at 2h and clearer at 48h in γ-imaging. In controls, the tumor was slightly visualized also to early stage, but faded away later on. Biotin-avidin pretargeting technique can elevate the T/NT ratio and decrease the blood background. Early imaging was obtained with better imaging quality

  15. 2004 annual report. Defense, safety, energy, information, health. CEA in the center of big European challenges; Rapport annuel 2004. Defense, securite, energie, information, sante. Le CEA au coeur des grands defis europeens

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This document is the 2004 annual report of the French atomic energy commission (CEA). It presents the R and D activities of the CEA in three main domains: 1 - defense and safety, maintaining perenniality of nuclear dissuasion and nuclear safety: supplying nuclear weapons to armies, maintaining dissuasion capability with the simulation program, sharing R and D means with the scientific community and the industrial world, designing and maintaining naval nuclear propulsion reactors, cleansing Marcoule and Pierrelatte facilities, monitoring treaties and fighting against proliferation and terrorism; 2 - energy, developing more competitive and cleaner energy sources: nuclear waste management, optimization of industrial nuclear activities, future nuclear systems and new energy technologies, basic research on energy, radiobiology and toxicology; 3 - information and health, valorizing industry thanks to technological research and supplying new tools for health and medical research: micro- and nano-technologies, software technologies, basic research for industrial innovation, nuclear technologies for health and bio-technologies. (J.S.)

  16. Selection of aptamers to Anti-CEA%癌胚抗原特异性单克隆抗体(Anti-CEA)核酸适配体的筛选

    Institute of Scientific and Technical Information of China (English)

    曾家豫; 万波; 马瑾; 袁红霞; 李星; 赵运旺; 廖世奇

    2015-01-01

    目的:筛选癌胚抗原(carcinoembryonic antigen,CEA)特异性单克隆抗体(Anti-CEA)的核酸适配体(aptamers),为肺癌血清肿瘤标志物核酸适配体的筛选奠定实验基础.方法:利用羧基化琼脂磁珠作为筛选介质,以Anti-CEA为筛选的目标靶分子,通过消减SELEX技术及实时定量PCR技术,从随机ssDNA文库中筛选出与Anti-CEA特异性结合的aptamers,并通过凝胶阻滞实验(EMSA)鉴定筛选到的Anti-CEA-aptamer复合物,然后将得到的第10轮富集文库扩增为双链DNA,通过切胶纯化后,连接PMD18-T载体,转化大肠杆菌DH5α感受态细胞,同时利用交错PCR技术鉴定阳性克隆,经测序,获得aptamers的序列.结果:经过10轮筛选得到了4条与Anti-CEA结合的aptamers,测序结果显示均为不同序列.结论:验证筛选出的与Anti-CEA结合的aptamer,特异性检测结果表明2号aptamer与靶分子结合的特异性很高,且与非特异蛋白无明显吸附,筛选出的aptamers用于识别Anti-CEA,将为肺癌的早期诊断和早期治疗提供新的突破口.

  17. Cea assessment of the sulphur-iodine cycle for hydrogen production

    International Nuclear Information System (INIS)

    The sulphur-iodine cycle is a promising process for hydrogen production using nuclear heat: - it is a purely thermochemical cycle, implying that hydrogen production will scale with volume rather than surface; - it only involves fluids, thus avoiding the often difficult handling of solids; - its heat requirements are well matched to the temperatures available from a Generation IV very/high temperature reactor. These characteristics seem very attractive for high efficiency and low cost massive hydrogen production. On the other hand, the efficiency of the cycle may suffer from the large over-stoichiometries of water and iodine and the very important heat exchanges it involves; furthermore, due to lack of adequate thermodynamic models, its efficiency is difficult to assess with confidence. Besides, the large quantities of chemicals that need to be handled, and the corrosiveness of these chemicals, are factors not to be overlooked in terms of investment and operation costs. In order to assess the actual potential of the sulphur-iodine cycle for massive hydrogen production at a competitive cost, CEA has been conducting an important programme on this cycle, ranging from thermodynamic measurements to hydrogen production cost evaluation, with flow sheet optimisation, component sizing and investment cost estimation as intermediate steps. The paper will present the method used, the status of both efficiency and production cost estimations, and discuss perspectives for improvement. (authors)

  18. Report on transparency and nuclear safety - Fontenay-aux-Roses CEA centre - 2012

    International Nuclear Information System (INIS)

    This report presents the different nuclear base installations (INB) of the Fontenay-aux-Roses CEA centre, gives an overview of measures regarding safety within these installations (organisation, general arrangements, arrangements related to different risks, defence in-depth, management of emergency situations, inspections, audits and second-level controls, arrangements and main events specific to the different installations and buildings, issues related to transports, soil radiological assessment) and measures related to radiation protection (organisation and results). It reports the significant events related to safety and radiation protection which occurred in 2012 and were declared to the ASN, and discusses how the return-on-experience has been used. It reports and comments the results of measurements of radiological and chemical gaseous and liquid effluents, of surveys of the environment. It also evokes important events related to these measurement and survey processes, presents the environmental management approach. The next part addresses the management of radioactive wastes: arrangements aimed at limiting the volume of warehoused wastes, and at limiting their impact on health and on the environment, nature and quantities of warehoused wastes. The different arrangements regarding transparency and information are reviewed (TSN report, newsletter, and so on)

  19. Meeting of Directors and Heads of Department from CEA-Saclay, France

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Directors and Heads of Department from the Saclay centre of the French atomic energy commission (CEA) visited CERN in December. They are pictured here at the LHC magnet test facility in building SM18. On the left behind the visitors are the test benches where magnets are prepared for installation in String 2: the 120-metre full-scale model of an LHC cell of the regular part of the arc, which can be seen to the right. Photos 01, 02: Left to right: Marc Dejardin, Alain Givernaud, Louis Laurent, François Kircher, Antoine Masurel, Joël Feltesse, André Menez, T. Taylor, Philippe Pradelles, Bernard Sevestre, Michel Roche, Jean-Yves Gascoin, Thierry Lieven, Michel Spiro, Jean-Pierre Pervès, Yves Lemoigne, Béatrice Reder, Georges Carola, Philippe Lebrun, Yves Bourlat, Bertrand Mercier, Jean-Paul Langlois, Patrick Laurent, Didier Moulin, Xavier Vitart, Marc Serre, Jean-Louis Pierrey, Patrick Jarry, Bruno Mansoulié, Stéphane Lequien, Hervé Barbelin, Philippe Pallier, Jean-Yves Guillamot, and Norbert Sioegel.

  20. Status of CEA reactor studies for a 200 kWe turboelectric Space Power System

    International Nuclear Information System (INIS)

    A reference design for a 200 kWe Space Nuclear Power System has been developed by the CNES and CEA Agencies of the French Government in order to assess within a first study phase running from mid 1984 to mid 1986, the key feasibility issues and the development cost of a Space Power System compatible with the version of the European launcher (ARIANE V), that will be available after 1995, and with adequate power range and lifetime performances for the missions considered at that time. The heat from a fast spectrum lithium cooled reactor is converted by a turboelectric system, selected for its technological readiness and for its advantage over thermionics and thermoelectricity, of minimizing the total mass of 100 to 300 kWe power systems, considering the available radiator area afforded by the specific ARIANE V geometrical features. A heat pipe radiator is preferred to an equivalent gas cooled system, for the increased reliability brought by the large number of independent cooling elements. The successive topics addressed in the paper, include a description of the system main components and steady state operating conditions, and the present views about the start up procedure and the reactor control

  1. Status of the CNES-CEA joint program on space nuclear Brayton systems

    International Nuclear Information System (INIS)

    A cooperative program between the French Centre National d'Etudes Spatiales (CNES) and the Commissariat a l'Energie Atomique (CEA) was initiated in 1983, to investigate the possible development of 20 to 200 kWe space nuclear power systems to be launched by the next version of the European launcher, Ariane V. After completion in 1986 of preliminary conceptual studies of a reference 200 kWe turbo-electric power system, an additional 3 year study phase was decided, with the double objective of assessing the potential advantage of nuclear power systems versus solar photovoltaic or dynamic systems in the 20 kWe power range, and comparing various reactor candidate technologies and system options for 20 kWe space nuclear power systems, likely to meet the projected energy needs of future European space missions. A comprehensive program including conceptual design studies, operating transient analyses and technology base assessment, is currently applied to a few reference concepts of 20 kWe nuclear Brayton and thermoelectric systems, in order to establish sound technical and economical bases for selecting the design options and the development strategy of a first space nuclear power system in Europe

  2. Status of CEA reactor studies for a 200 kWe turbo electric space power system

    International Nuclear Information System (INIS)

    The present European ARIANE space program will expand after 1995 in the development of the large ARIANE 5 launch vehicle. Considering, that the range of power needs (50 to 400 kWe) and operation times required for the space missions planned after the year 2000, are relevant to a nuclear power system, the French Centre National d'Etudes Spatiales (CNES) invited in 1983 the Commissariat a l'Energie Atomique (CEA) to undertake preliminary studies on space power systems. The purpose of the present two year phase (mid 1984-mid 1986) is to identify key technologies for a space generator within the power range of interest and to estimate the development cost of such a project to be examined for commitment in 1986. This work mainly consists in the feasibility and cost assessment of a reference 200 kWe turboelectric space generator, selected for the maturity and availability of the conversion system and for its attractive specific mass compared to thermionics and thermoelectricity, considering the available radiator area afforded by the specific ARIANE 5 geometrical features. The system is basically composed of a fast neutron spectrum lithium cooled reactor, of a Brayton conversion loop and of a heat pipe radiator

  3. Enxertia herbácea em Myrtaceae nativas do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Daiane Silva Lattuada

    2010-12-01

    Full Text Available O objetivo deste trabalho foi testar a viabilidade da técnica de enxertia herbácea em frutíferas nativas da família Myrtaceae. O experimento foi realizado em casa de vegetação do Departamento de Horticultura e Silvicultura/ UFRGS, em Porto Alegre. Duas espécies de Myrtaceae nativas foram usadas, tanto como porta-enxerto quanto como enxerto, Eugenia uniflora (Pitangueira e E. involucrata (Cerejeira-do-rio-grande ou Cerejeira-do-mato, totalizando quatro combinações. O método de enxertia adotado foi por garfagem em fenda cheia, em ramos herbáceos, com diâmetro médio do porta-enxerto de 0,1cm, enquanto os ramos dos enxertos apresentavam diâmetro médio entre 0,08 a 0,1cm, para as duas espécies. As análises foram quinzenais e, após 70 dias, foram analisadas estatisticamente a pega e a altura média das brotações emitidas. O delineamento experimental foi o completamente casualizado, com quatro repetições, sendo cada unidade experimental composta de cinco enxertos. Os resultados indicaram pega de 60% na combinação Pitangueira-Pitangueira (porta enxerto - enxerto. As demais combinações mostraram-se ineficientes.

  4. Light ion source for proton/deuteron production at CEA Saclay for the Spiral2 project

    International Nuclear Information System (INIS)

    The production of rare radioactive ion beam (RIB) far from the valley of stability is one of the final purposes of the Spiral2 facility in Caen. The RIB will be produced by impinging a deuteron beam onto a carbon sample to produce a high neutron flux, which will interact with a uranium target. The primary deuteron beam is produced by an ion source based on ECR plasma generation. The deuteron source and the low energy beam transport (LEBT) has been assembled and tested at CEA Saclay. Diagnostics from other laboratories were implemented on the LEBT in order to characterize the deuteron beam produced and compare it to the initial simulations. The ion source has been based on a SILHI-type source, which has demonstrated good performances in pulsed and continuous mode, and also a very good reliability on long term operation. The 5 mA of deuteron beam required at the RFQ entrance is extracted from the plasma source at the energy of 40 kV. After a brief description of the experimental set-up, this article reports on the first beam characterization experiments.

  5. Training and Certification Program for Certified Energy Auditors (CEA) and Certified Building Commissioning Professionals (CBCP)

    Energy Technology Data Exchange (ETDEWEB)

    Kent, Bill

    2012-08-24

    The Association of Energy Engineers (AEE) has offered energy efficiency training and certification programs for over 30 years. During that time AEE has certified more than 22,000 professionals. All of our certification programs are the result of extensive industry research and program development and oversight by certification boards. For this project award, AEE proposed to work with the Department of Energy to utilize and extend existing industry recognized Certified Energy Auditor (CEA) and Certified Building Commissioning Professional (CBCP) programs under this Training Program Development Announcement. These expanded training programs will have significant impact in training professionals for building commissioning and energy auditing to achieve the goal of bringing existing buildings up to their optimal energy performance potential and ensuring that new buildings maintain their expected optimal level of performance. The goals and objectives of the training development project were achieved with the development of new training programs that are now being offered as self-sustaining commercial training and certification programs. These new programs are training and certifying professionals who are accomplishing the goal of increasing building energy performance in both existing and new buildings.

  6. EURATOM-CEA association contributions to the 18. IAEA fusion energy conference

    Energy Technology Data Exchange (ETDEWEB)

    Ghendrih, Ph.; Peysson, Y.; Hoang, G.T. [and others

    2000-12-01

    The 9 contributions of EURATOM-Cea association to the fusion energy conference hold at Sorrento are gathered in this document with 7 additional papers. The different titles are: 1) Ergodic divertor experiments on the route to steady state operation of Tore-Supra, 2) High power lower hybrid current drive experiments in Tore-Supra tokamak, 3) Electron transport and improved confinement on Tore-Supra, 4) ECRH experiments and developments for long pulse in Tore-Supra, 5) Impurity penetration and contamination in Tore-Supra ergodic divertor experiments, 6) Real time plasma feed-back control: an overview of Tore-Supra achievements, 7) Numerical assessment of the ion turbulent thermal transport scaling laws, 8) Design of next step tokamak: consistent analysis of plasma flux consumption and poloidal, 9) Large superconducting conductors and joints for fusion magnets: from conceptual design to test at full size scale, 10) Burst-prone transport in tokamaks with internal transport barriers, 11) Electrostatic turbulence with finite parallel correlation length and radial electric field generation, 12) Theoretical issues in tokamak confinement: internal-edge transport barriers and runaway avalanche confinement, 13) Core and edge confinement studies with different heating methods in JET, 14) Confinement and transport studies of conventional scenarios in ASDEX upgrade, 15) First test results for the ITER central solenoid model coil, and 16) Progress of the ITER central solenoid model coil program.

  7. EURATOM-CEA association contributions to the 18. IAEA fusion energy conference

    International Nuclear Information System (INIS)

    The 9 contributions of EURATOM-Cea association to the fusion energy conference hold at Sorrento are gathered in this document with 7 additional papers. The different titles are: 1) Ergodic divertor experiments on the route to steady state operation of Tore-Supra, 2) High power lower hybrid current drive experiments in Tore-Supra tokamak, 3) Electron transport and improved confinement on Tore-Supra, 4) ECRH experiments and developments for long pulse in Tore-Supra, 5) Impurity penetration and contamination in Tore-Supra ergodic divertor experiments, 6) Real time plasma feed-back control: an overview of Tore-Supra achievements, 7) Numerical assessment of the ion turbulent thermal transport scaling laws, 8) Design of next step tokamak: consistent analysis of plasma flux consumption and poloidal, 9) Large superconducting conductors and joints for fusion magnets: from conceptual design to test at full size scale, 10) Burst-prone transport in tokamaks with internal transport barriers, 11) Electrostatic turbulence with finite parallel correlation length and radial electric field generation, 12) Theoretical issues in tokamak confinement: internal-edge transport barriers and runaway avalanche confinement, 13) Core and edge confinement studies with different heating methods in JET, 14) Confinement and transport studies of conventional scenarios in ASDEX upgrade, 15) First test results for the ITER central solenoid model coil, and 16) Progress of the ITER central solenoid model coil program

  8. The 400W at 1.8K Test Facility at CEA-Grenoble

    Science.gov (United States)

    Roussel, P.; Girard, A.; Jager, B.; Rousset, B.; Bonnay, P.; Millet, F.; Gully, P.

    2006-04-01

    A new test facility with a cooling capacity respectively of 400W at 1.8K or 800W at 4.5K, is now under nominal operation in SBT (Low Temperature Department) at CEA Grenoble. It has been recently used for thermohydraulic studies of two phase superfluid helium in autumn 2004. In the near future, this test bench will allow: - to test industrial components at 1.8K (magnets, cavities of accelerators) - to continue the present studies on thermohydraulics of two phase superfluid helium - to develop and simulate new cooling loops for ITER Cryogenics, and other applications such as high Reynolds number flows This new facility consists of a cold box connected to a warm compressor station (one subatmospheric oil ring pump in series with two screw compressors). The cold box, designed by AIR LIQUIDE, comprises two centrifugal cold compressors, a cold turbine, a wet piston expander, counter flow heat exchangers and two phase separators at 4.5K and 1.8K. The new facility uses a Programmable Logic Controller (PLC) connected to a bus for the measurements. The design is modular and will allow the use of saturated fluid flow (two phase flow at 1.8K or 4.5K) or single phase fluid forced flow. Experimental results and cooling capacity in different operation modes are detailed.

  9. CEA and AREVA HTR fuel particles manufacturing and characterization R and D Program

    International Nuclear Information System (INIS)

    Worldwide, renewal of interest for High Temperature Reactors (HTR) moderated by graphite, using helium gas as coolant is due to the possibility offered by HTR technology to build small competitive modular units (100-300 MWe) and to produce high temperature gas required for hydrogen production or heat production. In this context, Commissariat a l'Energie Atomique (CEA) supported by AREVA, conducts R and D projects on HTR, which one is the mastering of the UO2 TRISO fuel fabrication technology including innovating prospects. The first step of the work is to recover fabrication know-how and to improve fabrication processes (for preparing the erection of a fuel pilot manufacture line of HTR particles). The second step will be the manufacturing of HTR fuel elements in purpose of irradiation tests. This publication deals with the know-how recovery and improved processes of UO2 TRISO manufacture, i.e. kernel and coatings manufacturing, the development of innovative characterization methods, a modelling approach of CVD processes and the status of the future laboratory manufacture line. Alternative fuel designs are also investigated, for instance the way of manufacturing UCO and UCx kernels with higher refractory coating material such as ZrC. (authors)

  10. Report on transparency and nuclear safety - INB unexploited by the Marcoule CEA - 2012

    International Nuclear Information System (INIS)

    This report presents the different nuclear base installations (INB) of the Marcoule CEA centre, gives an overview of measures regarding safety within these installations (organisation, general arrangements, arrangements related to different risks, management of emergency situations, inspections, audits and second-level controls, arrangements and main events specific to the different installations and buildings) and of measures related to radiation protection (organisation and results, main events). It reports the significant events related to safety and radiation protection which occurred in 2012 and were declared to the ASN, and discusses how the return-on-experience has been used. It reports and comments the results of measurements of gaseous and liquid effluents, of their impact on the environment, and of surveys of the environment. It also presents the environmental management approach. The next part addresses the management of radioactive wastes which are warehoused on this site: arrangements aimed at limiting their volume, and at limiting their impact on health and on the environment, nature and quantities of warehoused wastes. Remarks and recommendations of the CHSCT are given

  11. Apprasial of the diagnostic value of combined detection of serum tumor markers (AFP, CEA, SF, TSA) for common malignancies

    International Nuclear Information System (INIS)

    Objective: To assess the detection rate of common malignancies with combined determination of four serum tumor markers (AFP, CEA, SF, TSA). Methods: Serum AFP, CEA, SF (with RIA) and TSA (with biochemical method) contents were determined in 612 patients with various kinds of proved malignancies. Results: Positive rates of combined determination of these four tumor markers for detection of common malignancies were: 95.2%(79/83) for liver carcinoma, 92.6% (125/135) for lung carcinoma, 88.5% (115/130) for gastric cancer, 83.3% (60/72) for colorectal cancer, 84.2% (85/101) for breast cancer, 90.0% (9/10) for chorionepithelioma and 88.9% (72/81) for ovarian cancer. Conclusion: Combined determination of these four tumor markers for screening malignancies is simple, cheap, practical and worth popularization. (authors)

  12. Estrutura da vegetação herbácea em paisagens ciliares no sul de Santa Catarina, Brasil

    OpenAIRE

    Aline Votri Guislon; Karoline Ceron; Guilherme Alves Elias; Robson Santos; Vanilde Citadini-Zanette

    2016-01-01

    As características estruturais e ecológicas da vegetação herbácea fazem com que ela seja sensível às alterações do ambiente, atuando como indicador da qualidade ambiental. No entanto, o estudo dessa comunidade ainda é incipiente em regiões neotropicais. Este estudo descreve a florística e os aspectos fitossociológicos da vegetação herbácea terrícola na mata ciliar de sete rios, no município de Urussanga, sul do estado de Santa Catarina, além de analisar e quantificar o status do conhecimento ...

  13. Larva migrans within scalp sebaceous gland Larva migrans em glândula sebácea do couro cabeludo

    Directory of Open Access Journals (Sweden)

    Lucinda Calheiros Guimarães

    1999-04-01

    Full Text Available A case of larva migrans or serpiginous linear dermatitis on the scalp of a teenager is reported. An ancylostomid larva was found within a sebaceous gland acinus. The unusual skin site for larva migrans as well as the penetration through the sebaceous gland are highlighted. The probable mechanism by which the parasite reached the skin adnexa is discussed.Relata-se caso de larva migrans ou dermatite linear serpiginosa no couro cabeludo de adolescente, no qual o ancilostomídeo foi encontrado no interior de glândula sebácea. Destaca-se a possibilidade do helminto sediar-se em locais pouco usuais, das glândulas sebáceas serem via de penetração de larvas na pele e discute-se o provável mecanismo pelo qual o agente implantou-se no anexo cutâneo.

  14. Analysis of the radiochemical purity of DTPA-coupled anti-CEA monoclonal antibody labelled with samarium-153

    International Nuclear Information System (INIS)

    Objective: To establish a paper chromatography method for analyzing radiochemical purity of cyclic DTPA anhydride coupled anti-CEA monoclonal antibody (McAb) labelled with 153Sm. Methods: The separation efficacy of free 153Sm3+ and 153Sm-CEA McAb was determined with a variety of paper chromatograph systems. The optimal separation conditions were studied, and the result determined with this paper chromatography compared with that of Sephadex G-50 chromatograph. Results: The optimal separation condition of the paper chromatograph system was as follows: Tributyl phosphate: 2-butanone: ethyl acetate (V/V/V = 4/10/3) as solvent and No. 1 Xinhua filter paper immerged with 30% ammonium nitrate for 30 min. and then dried as carrier. The percentage of labelling field determined with this paper chromatography was consistent with that of Sephadex G-50 chromatograph. Conclusion: It is showed this method proves to be simple, convenient and can be rapidly performed

  15. Asclepiadáceas nuevas o interesantes de colombia y países vecinos

    OpenAIRE

    2012-01-01

    Una parte importante de mi estudio de la flora costeña de Colombia, al cual hállome dedicado hace ya muchos años, ha sido la de obtener en la llanura del Caribe, preferentemente cerca de Cartagena o en el vecino Departamento del Atlántico, ejemplares de las especies que NICOLÁS J. JACQUIN(1727-1817) coleccionó hace dos siglos (1758) en los alrededores de Cartagena y que describió, generalmente con buen detalle morfológico, en la obra titulada Selectarum Stirpium Americanarum Historia, publica...

  16. Estimation of Public Health consequences of Tchernobyl nuclear accident (26 April 1986) based on CEA centers measurements

    International Nuclear Information System (INIS)

    Based on fallout measurements, additional radiation doses to the French population from external exposure to the plume, inhaled radioactivity and consumption of milk, meat and vegetables, have been estimated for the first period following the Chernobyl accident, by the various CEA centers in different regions of the country. Effective dose equivalent from the various exposures and radiation measurements in the different centers are presented in tables

  17. Tumour-associated trypsin inhibitor (TATI) in human ovarian cyst fluid. Comparison with CA 125 and CEA.

    OpenAIRE

    Halila, H.; Huhtala, M. L.; Haglund, C.; Nordling, S.; Stenman, U. H.

    1987-01-01

    The levels of tumour-associated trypsin inhibitor (TATI), CA 125 and CEA were measured in ovarian cyst fluids from 21 patients. TATI in cyst fluid was immunologically and physicochemically similar to the peptide originally isolated from the urine of a patient with ovarian cancer. Mucinous cysts contained significantly higher levels of TATI than did serous cysts. Immunohistochemically TATI was localized in the apical parts of cells of mucinous ovarian cysts. These results suggest that this tum...

  18. Direct compatibility check of the CEA and Cornell electroproduction pion form factor data with e+e- ones

    International Nuclear Information System (INIS)

    Using precise experimental information on the imaginary part of the pion form factor from e+e- → π+π- up to the inelastic threshold and QCD constraints for it in the range of momenta (mπ0+mω)2 < t < infinity, was investigated by means of a dispersion integral the reliability of individual electroproduction CEA and Cornell model-dependent pion form factor data points

  19. A Case of Radiation Fibrosis Appearing as Mass-Like Consolidation after SBRT with Elevation of Serum CEA

    Directory of Open Access Journals (Sweden)

    Kotaro Terashima

    2010-01-01

    Full Text Available We report a case of radiation fibrosis appearing as mass-like consolidation, which was difficult to distinguish from local recurrence. A 72-year-old woman was diagnosed as having primary lung cancer (cT1N0M0 stage IA in the right upper lobe and was treated with SBRT of 48 Gy in 4 fractions. After 12 months, mass-like consolidation appeared around the irradiated area, and after 13 months, it had increased in size. FDG-PET revealed high uptake (SUV max=5.61 for the consolidation. CT-guided biopsy was performed, but we could not confirm the diagnosis. Considering her poor respiratory function and her age, short-interval follow-up was performed. After 15 months, the consolidation enlarged at the dorsal side, and carcinoembryonic antigen (CEA became elevated (14.6 ng/mL. Serum KL-6 (436 U/mL and SP-D (204 ng/mL were also elevated. However, after 16 months, serum CEA slightly decreased. The consolidation gradually retracted on follow-up CT images. CEA, KL-6, and SP-D were also decreased by degrees. After 40 months, there is no evidence of local recurrence.

  20. Multimodality treatment of primary nonresectable intrahepatic cholangiocarcinoma with I-131 anti-CEA: A radiation therapy oncology group study

    International Nuclear Information System (INIS)

    Thirty-seven patients (57% with metastasis and/or who has previously undergone chemotherapy) with primary unresectable intrahepatic cholangiocarcinoma were prospectively treated with external beam radiation therapy, chemotherapy, and I-131 anti-carcinoembryonic antigen (CEA) antibody. The regimen led to partial remission in 26.6% of patients, according to CT scan digitized tumor volume analysis, and in 33.3% (25.9% with partial remission, 7.4% with complete emission) according to physical examination findings. Therapy began with whole liver irradiation (2.1 Gy, 0.3 Gy per fraction, delivered 4 days a week, with 10-MV photons) and, on alternate days, chemotherapy (Adriamycin, 15 mg, + 5-fluorouracil [5-FU], 500 mg). One month later, Adriamycin, 15 mg, + 5-FU, 500 mg, was administered on day 0; 20 mCi of I-131 anti-CEA on day 1; and 10 mCi of I-131 anti-CEA on day 6. Tumor effective half-life was 3-5 days. Median tumor dose (20 mCi + 10 mCi) was 6.2 Gy. Antibody therapy was administered in 2-month cycles. Grade IV thrombocytopenia and leukopenia each occurred in 3.2% of patient administrations. Median survival for the entire group was 6.5 months; for responders, it was 15.2 months. The longest partial remission is presently more than 4 years