WorldWideScience

Sample records for cea grenoble

  1. Report transparency and nuclear safety 2007 CEA Grenoble; Rapport transparence et securite nucleaire 2007 CEA Grenoble

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Grenoble for the year 2007. Since 2002 the Passage project aims to realize the decontamination and the dismantling of old nuclear installations of the CEA Grenoble. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the year 2007 saw two main steps of the Passage project: the decommissioning of the Siloette reactor, a public consultation about the Lama laboratory dismantling. (A.L.B.)

  2. Grenoble

    OpenAIRE

    Badin de Montjoye, Alain

    2013-01-01

    Identifiant de l'opération archéologique : 9845 Date de l'opération : 2008 (SU) Des travaux conduits par le service des Monuments Historiques au chevet de la cathédrale de Grenoble sont à l’origine d’une intervention d’urgence sur une partie des vestiges enfouis du système défensif urbain. Une première fouille de reconnaissance, décidée en prévision de ces travaux de restauration, avait déjà été réalisée en 2002, qui elle-même faisait suite à deux campagnes menées en 1993 et 1994. Il aura don...

  3. CEA

    Institute of Scientific and Technical Information of China (English)

    黑木政秀

    2005-01-01

    @@ 癌胎抗原(carcinoembryonic antigen)简称为CEA,是由加拿大Gold和Freedman(1965年)发现的,它作为成人消化系统癌和胎儿消化系统特异性抗原,故命名为carcino (癌)+ embryo(胚胎)抗原.之后,在消化系统以外的脏器的癌也发现有表达,目前已成了临床最广泛、最常用的肿瘤标志物.

  4. Radioactivity and radioprotection: the every day life in a nuclear installation. Press tour at CEA/GRENOBLE 18 november 1999; Radioactivite et radioprotection: la vie quotidienne dans une installation nucleaire. Voyage de presse au Centre CEA/CADARACHE 18 novembre 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    In the framework of the public information, this paper gives a general information on the radioactivity and the radioprotection at the CEA/Cadarache center. A first part is devoted to a presentation of the radioactivity with definitions and radiation effects on the human being and the environment. An other part presents the radioprotection activities and regulations. The last part deals with specific activities of the CEA/Cadarache: the CASCAD installations for spent fuels storage, the LECA Laboratory for the Examination of Active Fuels and a dismantling installation for big irradiated objects. Historical aspects of the CEA/Cadarache are also provided. (A.L.B.)

  5. [Detection of Australia antigen in Grenoble].

    Science.gov (United States)

    Steyger, E; Micouin, C; Magnin, R

    1975-06-01

    The reverse passive hemaggluatination (RPH) technique for HB ag. detection is presently used at the Grenoble Blood Center; this technique has been slightly modified with a view to lowering the cost. A microtechnique which gave preliminary good results, is also described.

  6. The CEA and the alternative energies. Press tour 25 and 26 november 1999; Le CEA et les energies alternatives. Voyage de presse les 25 et 26 novembre 1999

    Energy Technology Data Exchange (ETDEWEB)

    Carola, G. [CEA/Grenoble, 38 (France); Ngo, Ch. [CEA, Dir. de la Strategie et de l' Evaluation, 75 - Paris (France); Mermilliod, N.; Serre-Combe, P. [CEA/Grenoble, Dir. des Technologies Avancees, DTA, 38 (France); Sanglan, P. [Air Liquide, 38 - Sassenage (France); De La Graviere, M. [CEA/Cadarache, 13 - Saint-Paul-lez-Durance (France); Dieudonne, O.; Malbranche, Ph. [CEA/Cadarache, Dir. des Reacteurs Nucleaires, DRN, 13 - Saint-Paul-lez-Durance (France)

    1999-11-01

    In the framework of the public information on the CEA center of Cadarache and Grenoble, a presentation of the researches concerning the alternative energies is proposed. The Cea is commissioned by the Public Authorities, to keep the nuclear option open and for the long-dated, to develop renewable energies. In this domain researches on fuel cells and photovoltaic solar energy are performed. The principle and the applications of the fuel cell and the photovoltaic are recalled to introduce the research programs and the partners. (A.L.B.)

  7. [Pediatric emergencies in the Grenoble Medical Center].

    Science.gov (United States)

    Lebrun, E; Bost, M

    1988-01-01

    In the Grenoble Medical Centre, pediatric emergency admissions have been drastically influenced by the opening of an Emergency Unit in May 1983. Our work was carried out one year after the opening in order to study the characteristics of the admitted children. The enquiry was done over 4 months, one month for each season of that year. A total of 1,382 children were included in the study. Thirty-four percent were seen for a medical advice (66% hospitalized). Children seen for medical advice are younger and mostly migrants. They live close to the hospital and are brought most often for fever. Fifty one per cent directly brought to the hospital by their parents for a first pediatric advice (49% were sent by their personal physician). Children directly brought by their parents are in majority infants and migrants. They are mostly admitted at night and morning and during the week-end. They are more frequently followed within the public mother-child health protection system ("Service de Protection Maternelle et Infantile", PMI).

  8. CEA sustainable development report 2007; CEA rapport developpement durable 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities in the domain of the sustainable development. The first part is devoted to the environment preservation policy (energy, water, air, chemistry, wastes, transport, buildings). The second part shows the dynamic governance in the domain of the risks management. The last part presents the CEA activities of research for the sustainable development. (A.L.B.)

  9. CEA Annual report 2007; CEA rapport annuel 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities for the year 2007 in these three main areas: science and technology working for nuclear deterrence and global security, the energies without greenhouse effect gases emission against the climatic change, researches in the information sciences and technologies for a better communication and health. The CEA safety, organization, communication and international relations are also presented. (A.L.B.)

  10. Providing for Disabled Students: University of Grenoble, France.

    Science.gov (United States)

    PEB Exchange, 2000

    2000-01-01

    Examines how France's University of Grenoble provides for its disabled students in its residence halls, including a description of the university's service for disabled service. A hospital/education center where disabled students can receive care and physiotherapy while attending school is highlighted. (GR)

  11. CEA financial report 2007; CEA rapport financier 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This document provides financial data on the CEA for the year 2007. The management report (budget, resources, expenditures) and the accounting are detailed. The main management events of the year 2007 are presented. (A.L.B.)

  12. Scientific evaluation at the CEA; Evaluation scientifique au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1998. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 5 parts dealing successively with: part 1 - the CEA, a public research organization (civil nuclear research, technology research and transfers, defence activities); the scientific and technical evaluation at the CEA (general framework, evaluation of the IPSN and DAM); part 2 - the scientific and technical councils (directions of fuel cycle, of nuclear reactors, and of advanced technologies); part 3 - the scientific councils (directions of matter and of life sciences); the nuclear protection and safety institute; the direction of military applications; part 4 - the corresponding members of the evaluation; part 5 - the list of scientific and technical councils and members. (J.S.)

  13. CEA 2005 annual report; CEA rapport annuel 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This document is the 2005 activity report of the French atomic energy commission (CEA). The CEA is a main actor of nuclear research, development and innovation and is involved in three main domains: energy, defense/security, and information/health technologies thanks to high quality research works. With a manpower of 15000 researchers and collaborators with internationally acknowledged competences, the CEA is a driving force of industrial innovation and develops partnerships with French and European industries. It also warrants the perenniality of nuclear dissuasion. This report presents these different aspects of the CEA activities: 1 - defense-security: simulation program, opening to the scientific community, nuclear warheads, nuclear propulsion, cleansing of Rhone valley facilities, permanent monitoring of treaties respect, fight against terrorism; 2 - energy: optimization of the industrial park, advances in long lived radioactive wastes management, future nuclear systems, cleansing and dismantling integration, European nuclear energy research, new energy technologies; 3 - information and health technologies: major challenge of micro- and nano-technologies, key role of software technologies and complex systems; 4 - big research facilities opened to the scientific and industrial communities; 5 - scientific status: scientific evaluation process, prices and honors; 6 - programs support: revisited strategic control, confirmed simplification, active employment and training policy, teaching and training, technological valorization, international relations, communication, continuous quality approach, mastery of facilities safety, security, environmental control, a key-year for information systems. A financial report is attached to the document. (J.S.)

  14. CEA - Annual report 2006; CEA - Rapport annuel 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The CEA, a prominent player in research development and innovation, is active in 3 main areas: energy, health care and information technology and defense and security. This annual report presents the CEA activity for the year 2006 in these three main areas: Science and technology working for nuclear deterrence and global security (the simulation programs, the nuclear warheads, the nuclear propulsion, the decommissioning, the fighting against nuclear proliferation and monitoring international treaties, the global security); health and information technology (micro and nano technologies and systems); energy from nuclear fission and fusion and other technologies that do not emit greenhouse gases (progress for the nuclear industry, sustainable management of radioactive materials and waste, nuclear systems of the future, new energy technologies). (A.L.B.)

  15. [Organ cryopreservation: current status of research carried out in Grenoble].

    Science.gov (United States)

    Descotes, J L; Payen, E; Rambeaud, J J; Peuridieu, J F; Baudot, A; Odin, J; Mazuer, J; Boutron, P; Delon-Martin, C; Dupeyre, R

    1995-12-01

    After discussing the problem of organ cryopreservation and reviewing the current data available on this subject, the Grenoble project is presented. Physical and biological studies have been combined with experimentation of autologous renal transplantation in rabbits to assess the functional value of the retransplanted organ after treatment and cooling. Renal resistances are measured during perfusion of the kidney with the cryoprotective solution. In order to verify the homogeneity of the cryoprotector concentration in the organ, on NMR spectral imaging test has been developed. A new rapid imaging method now allows real time monitoring of concentration variations during perfusion. In addition to concentration and homogeneity, analysis of local spectra also provides information about the local temperature de the kidney.

  16. Las Gramináceas

    Directory of Open Access Journals (Sweden)

    Robledo Emilio

    1939-08-01

    Full Text Available Las gramináceas son plantas conocidas desde la antigüedad más remota. Tan importantes son las gramináceas desde el punto de vista bromatológico, que los hombres pueden ser clasificados en comedores de trigo, de arroz, de maíz, de mijo, de sorgo, de tocusso, de tef, etc. El área de distribución de las gramíneas es inmensa: se las encuentra desde las orillas del mar y en las aguas dulces, hasta las nieves perpetuas; sólo en las aguas saladas desconocidas. En punto de tamaño, las hay desde unos centímetros hasta nuestra guadua gigantesca, de treinta y más metros de altura. Dicha distribución se halla en relación con el clima, pero también es influida por los hábitos de los pueblos, por la civilización, por el comercio o por otras circunstancias.

  17. Memoirs of a Cea veteran

    Energy Technology Data Exchange (ETDEWEB)

    Puill, A

    2001-07-01

    A brief account is given of the way in which nuclear energy has developed in France and elsewhere over the last fifty years: options developed by the French Atomic Energy Commission (CEA), naval propulsion, development of pressurised water reactors, MOX and thorium fuels. Afterwards, the prospectives for the 21. century will be discussed. Considering that natural resources are depleting while releases of both greenhouse gases and world population are increasing, an active energy policy will have to be implemented with due consideration for social equity and solidarity. It is in this context that the developed countries will have to give preference, beyond savings, to renewable sources of energy, including of course, nuclear energy. Nuclear energy can continue to develop in the long term, provided fast breeder technology is developed at some point. As far as transport is concerned, hydrogen technology, which is clean and renewable, is promising, provided it is generated by nuclear energy. (author)

  18. [Prevalence of obesity amount elementary school children in Grenoble].

    Science.gov (United States)

    Viguié, M; Fayard, M; Micheletti, P; Boussuges, S

    2002-12-01

    Facing the growing increase of childhood obesity in France, the Grenoble Municipal School Health Service wanted to evaluate the importance of this phenomenon present among elementary school children in the area. A descriptive, cross-sectional and retrospective survey was conducted during the 2000/2001 academic year among a group of 1361 children born in 1990. The Quetelet Index was utilized to measure the level of being overweight, and the breaking point levels for being overweight and obese were defined according to new international standards. The prevalence of obesity is approximately 3% (2.7% in girls and 2.9% in boys) and remains constant from nursery school to elementary school. Nearly 35% of obese children in nursery school remain obese at the end of elementary school. Overweight prevalence is at its highest and increases significantly from nursery school (8.3%) through elementary school (14%). The study further revealed that girls aged 10-12 who did not pass and were held back from the next grade are five times more at risk of obesity than those who pass. The Municipal School Health Service has a critical role to play in the prevention of childhood obesity and its early screening and detection.

  19. Decontamination and dismantling at the CEA; L'assainissement et le demantelement au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This document presents the dismantling policy at the CEA (French Research Center on the atomic energy), the financing of the decontamination and the dismantling, the regulatory framework, the knowledge and the technology developed at the CEA, the radiation protection, the environment monitoring and the installations. (A.L.B.)

  20. Virtual Visit to the ATLAS Control Room during the "Nuit des deux infinis", Grenoble

    CERN Multimedia

    ATLAS Experiment

    2012-01-01

    October 9, 2012 will be held the first "Night of two infinities", organized by the Laboratories of Excellence P2IO and ENIGMASS on two sites: Massy and Grenoble. This general public event will be held each year in a similar way to other "Nights" that became famous as the "Night of Museums, the "White Night "and the "Night of the Stars." During this event a short virtual visit of the ATLAS Control Room will be organized. The ACR will be briefly presented to the audience (~2000 people). A few questions will be taken from Massy and Grenoble.

  1. Development activities on NIR large format MCT detectors for astrophysics and space science at CEA and SOFRADIR

    Science.gov (United States)

    Boulade, Olivier; Moreau, Vincent; Mulet, Patrick; Gravrand, Olivier; Cervera, Cyril; Zanatta, Jean-Paul; Castelein, Pierre; Guellec, Fabrice; Fièque, Bruno; Chorier, Philippe; Roumegoux, Julien

    2016-07-01

    CEA and SOFRADIR have been manufacturing and characterizing near infrared detectors in the frame of ESA's near infrared large format sensor array roadmap to develop a 2Kx2K large format low flux low noise device for space applications such as astrophysics. These detectors use HgCdTe as the absorbing material and p/n diode technology. The technological developments (photovoltaic technology, readout circuit, ...) are shared between CEA/LETI and SOFRADIR, both in Grenoble, while most of the performances are evaluated at CEA/IRFU in Saclay where a dedicated test facility has been developed, in particular to measure very low dark currents. The paper will present the current status of these developments at the end of ESA's NIRLFSA phase 2. The performances of the latest batch of devices meet or are very close to all the requirements (quantum efficiency, dark current, cross talk, readout noise, ...) even though a glow induced by the ROIC prevents the accurate measurement of the dark current. The current devices are fairly small, 640x512 15μm pixels, and the next phase of activity will target the development of a full size 2Kx2K detector. From the design and development, to the manufacturing and finally the testing, that type of detector requests a high level of mastering. An appropriate manufacturing and process chain compatible with such a size is needed at industrial level and results obtained with CEA technology coupled with Sofradir industrial experience and work on large dimension detector allow French actors to be confident to address this type of future missions.

  2. Management of Teaching Activities at the Universite Scientifique et Medicale de Grenoble.

    Science.gov (United States)

    Bornarel, Jean

    1985-01-01

    Cost-per-student assessments resulting from changes in the Scientific and Medical University of Grenoble's statutes to improve accountability, including budgeting changes, and measures to improve teaching loads and human resource management suggest that the French university system is ill-adapted to efforts to improve performance. (Author/MSE)

  3. Remodelling of a Lycee in Grenoble. Programme on Educational Building 14.

    Science.gov (United States)

    Roche, G.

    The 1973 remodeling of the Emmanuel Mounier Lycee in Grenoble, France, shows how a secondary educational facility can respond to expanding school offerings. As background to the lycee's expansion, the author, who was principal of the school during its remodeling, provides general information on the French educational system and on the consequent…

  4. L'orologio solare a riflessione del Liceo Stendhal di Grenoble (Francia)

    Science.gov (United States)

    del Favero, Enrico

    2004-03-01

    This paper describes history and features of the great reflecting sundial involving 100 m2 of a stair wall in the Liceo Internazionale Stendhal of Grenoble, southern France. The sundial, built in 1673 by the jesuit father Jean Bonfa, contains hourly and diurnal lines of various types and also some moon-solar astronomical instruments.

  5. 1999 scientific evaluation at the CEA; L'evaluation scientifique 1999 au CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1999. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 4 parts dealing successively with: 1)the CEA, a public research organization (strategy, research programs, new organization of the CEA activities, civil nuclear research, technology research and transfer, defence activities, transfer of knowledge) 2)the scientific evaluation at the CEA (evaluations of the civil applications of the CEA, IPSN, DAM, INSTN (national institute for nuclear sciences and techniques) 3)synthesis of the 1999 scientific and technical evaluation for each operational directions of the CEA (directions of fuel cycle, of nuclear reactors, of advanced technologies, of materials sciences, of life sciences, of military applications, of the nuclear protection and safety institute and of the national institute for nuclear sciences and techniques) 4)the corresponding members of the evaluation and the list of scientific and technical councils and members.

  6. Neutron-capture experiment on 77Se with EXILL at ILL Grenoble

    Directory of Open Access Journals (Sweden)

    Lorenz Ch.

    2015-01-01

    Full Text Available The neutron capture reaction at 77Se has been studied with cold neutrons in the course of the EXILL campaign at the high-flux reactor of the Institut Laue-Langevin Grenoble. A simulation of the detector array with Geant4 has been accomplished and evaluated. The detector response has been deduced and measured spectra were unfolded, which have been compared with simulations using γDex to determine strength functions.

  7. [Present frequency of the different Serratia species isolated in Grenoble University Hospital Center (author's transl)].

    Science.gov (United States)

    Croize, J; Le Noc, P

    1977-11-01

    Our study concerns 111 Serratia isolated during a period of seven months in a Grenoble hospital. The different species of Serratia are present with a high predominance of S. marcescens. Distribution, particular biochemical characteristics are discussed, and results of sensitivity to antibiotics, as well for antibiotics used against Gram negative bacteria as for the three quinolines against urinary bacteria. The place of Serratia in the hospital infections is discussed in the last part of this study.

  8. Neutron-capture experiment on 77Se with EXILL at ILL Grenoble

    Science.gov (United States)

    Lorenz, Ch.; John, R.; Massarczyk, R.; Schwengner, R.; Blanc, A.; de France, G.; Jentschel, M.; Köster, U.; Mutti, P.; Simpson, G.; Soldner, T.; Urban, W.; Valenta, S.; Belgya, T.

    2015-05-01

    The neutron capture reaction at 77Se has been studied with cold neutrons in the course of the EXILL campaign at the high-flux reactor of the Institut Laue-Langevin Grenoble. A simulation of the detector array with Geant4 has been accomplished and evaluated. The detector response has been deduced and measured spectra were unfolded, which have been compared with simulations using γDex to determine strength functions.

  9. An investigation of ozone and planetary boundary layer dynamics over the complex topography of Grenoble combining measurements and modeling

    OpenAIRE

    Couach, O.; Balin, I.; Jiménez, R; P. Ristori(CEILAP); Perego, S.; Kirchner, F.; Simeonov, V.; Calpini, B.; H. Bergh

    2003-01-01

    This paper concerns an evaluation of ozone (O3) and planetary boundary layer (PBL) dynamics over the complex topography of the Grenoble region through a combination of measurements and mesoscale model (METPHOMOD) predictions for three days, during July 1999. The measurements of O3 and PBL structure were obtained with a Differential Absorption Lidar (DIAL) system, situated 20 km south of Grenoble at Vif (310 m ASL). The combined lidar observations ...

  10. The CEA's waste management strategy; La strategie de gestion des dechets du CEA

    Energy Technology Data Exchange (ETDEWEB)

    Behar, Ch. [CEA Saclay, Dir. de l' Energie Nucleaire, 91 - Gif-sur-Yvette (France); Dall' ava, D. [CEA Saclay, Dir. de l' assainissement et du demantelement nucleaire, 91 - Gif-sur-Yvette (France); Fillion, E. [CEA Fontenay-aux-Roses, Direction de la protection et de la surete nucleaire, 92 (France)

    2011-02-15

    The CEA is tasked with carrying out certain research activities: within the Military Applications Division (DAM), research is focused on the nuclear deterrence and, within the Nuclear Energy Division, on developing the industrial nuclear systems of the future and optimising existing nuclear systems in partnership with EDF and AREVA. These major research and development themes entail a need for nuclear research and support facilities which must be maintained at a high level of performance and safety and, also, constantly upgraded to handle the research activities and programmes for which they are used. The CEA strategy is based on the right packaging of the radioactive liquid or solid waste into a form required for its transport, storage or disposal. The Caraibes software allows an efficient traceability of the waste packages. Most of the radioactive effluent processing stations of CEA are being upgraded

  11. Remote manipulators and mobile robots in the CEA; Telemanipulation et robotique mobile au CEA

    Energy Technology Data Exchange (ETDEWEB)

    Detriche, J.M. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. des Procedes et Systemes Avances

    1995-05-01

    Thanks to Jean Vertut`s works in the seventies, the CEA has been a pioneer in nuclear remote manipulation and mobile robots conception and has developed innovating systems in response to industry request. During the nineties, improvements in computer control systems have led to the realization of functional demonstrators. In 1995, advances in technology have allowed to consider the first industrial applications of nuclear remote manipulators and robots. This paper gives a review of the development and research works carried out by the CEA in this domain since the seventies, and also some future prospects. (J.S.). 10 figs.

  12. Wetting by Liquid Metals—Application in Materials Processing: The Contribution of the Grenoble Group

    Directory of Open Access Journals (Sweden)

    Nicolas Eustathopoulos

    2015-03-01

    Full Text Available The wettability of ceramics by liquid metals is discussed from both the fundamental point of view and the point of view of applications. The role of interfacial reactions (simple dissolution of the solid in the liquid or formation of a layer of a new compound is illustrated and analysed. Several results are presented in order to illustrate the role of wettability in materials processing, namely infiltration processing, joining dissimilar materials by brazing and selecting crucibles for crystallising liquid metals and semiconductors. The review includes results obtained during the last 15 years mainly, but not only, by the Grenoble group.

  13. SURGETICA at Grenoble: from computer assisted medical interventions to quality inspired surgery.

    Science.gov (United States)

    Cinquin, P; Troccaz, J; Champleboux, G; Lavallee, S

    2004-01-01

    Research on "Computer Assisted Medical Interventions" (CAMI) was initiated in Grenoble in 1984, as an attempt to take up the challenge of "Minimally Invasive Interventions", thanks to the introduction of Information and Communication Techniques in the Operating Room. In a first section, we will describe our initial vision. The corresponding achievements will then be presented. A final section will show that the challenge now is to "invert this movement": instead of moving the computer in the Operating Room, we should embed the surgeon (or at least his or her expertise) into the Information Technology based tools he or she uses.

  14. Simplifying CEA through Excel, VBA, and Subeq

    Science.gov (United States)

    Foster, Ryan

    2004-01-01

    Many people use compound equilibrium programs for very different reasons, varying from refrigerators to light bulbs to rockets. A commonly used equilibrium program is CEA. CEA can take various inputs such as pressure, temperature, and volume along with numerous reactants and run them through equilibrium equations to obtain valuable output information, including products formed and their relative amounts. A little over a year ago, Bonnie McBride created the program subeq with the goal to simplify the calling of CEA. Subeq was also designed to be called by other programs, including Excel, through the use of Visual Basic for Applications (VBA). The largest advantage of using Excel is that it allows the user to input the information in a colorful and user-friendly environment while allowing VBA to run subeq, which is in the form of a FORTRAN DLL (Dynamic Link Library). Calling subeq in this form makes it much faster than if it were converted to VBA. Since subeq requires such large lists of reactant and product names, all of which can't be passed in as an array, subeq had to be changed to accept very long strings of reactants and products. To pass this string and adjust the transfer of input and output parameters, the subeq DLL had to be changed. One program that does this is Compaq Visual FORTRAN, which allows DLLs to be edited, debugged, and compiled. Compaq Visual FORTRAN uses FORTRAN 90/95, which has additional features to that of FORTRAN 77. My goals this summer include finishing up the excel spreadsheet of subeq, which I started last summer, and putting it on the Internet so that others can use it without having to download my spreadsheet. To finish up the spreadsheet I will need to work on debugging current options and problems. I will also work on making it as robust as possible, so that all errors that may arise will be clearly communicated to the user. New features will be added old ones will be changed as I receive comments from people using the spreadsheet

  15. A recombinant vaccinia virus expressing human carcinoembryonic antigen (CEA).

    Science.gov (United States)

    Kaufman, H; Schlom, J; Kantor, J

    1991-07-30

    Carcinoembryonic antigen (CEA) is a 180-kDa glycoprotein expressed on most gastrointestinal carcinomas. A 2.4-kb cDNA clone, containing the complete coding sequence, was isolated from a human colon tumor cell library and inserted into a vaccinia virus genome. This newly developed construct was characterized by Southern blotting, DNA hybridization studies, and polymerase chain reaction analysis. The CEA gene was stably integrated into the vaccinia virus thymidine kinase gene. The recombinant was efficiently replicated upon serial passages in cell cultures and in animals. The recombinant virus expresses on the surface of infected cells a protein product recognized by a monoclonal antibody (COL-I) directed against CEA. Immunization of mice with the vaccinia construct elicited a humoral immune response against CEA. Pilot studies also showed that administration of the recombinant CEA vaccinia construct was able to greatly reduce the growth in mice of a syngeneic murine colon adenocarcinoma which had been transduced with the human CEA gene. The use of this new recombinant CEA vaccinia construct may thus provide an approach in the specific active immunotherapy of human GI cancer and other CEA expressing carcinoma types.

  16. E-learning for students in their first year: a French experimentation at the medical school of Grenoble.

    Science.gov (United States)

    Renard, Jean-Marie; Pagonis, Daniel; Vuillez, Jean-Philippe; Romanet, Jean-Paul; Sele, Bernard

    2007-01-01

    A local study carried out in the Medical School of Grenoble shows that teaching in the first year in medicine studies satisfies neither the students, nor the teachers. The Faculty of Medicine of Grenoble decided to set up a reform in order to offer a high quality education. This reform leads to a complete reorganization of the curriculum and to the intensive use of new information and communication technologies of information, in particular, the use of multimedia documents. The communication and information technologies team of the Faculty of Medicine of Grenoble carried out an innovating and daring reform to start at the academic year 2006-2007. The new course is built on three activities: self learning on multi-media resources, meetings with teachers for questions-answers sessions and tutorials animated by older students. This article reports the first results for this successful project. In the academic year 2006-2007, are concerned 1290 students, 40 teachers and 8 disciplines.

  17. Carcinoembryonic antigen (CEA) as tumor marker in lung cancer

    DEFF Research Database (Denmark)

    Knudsen, Mie Grunnet; Sorensen, J B

    2012-01-01

    The use of CEA as a prognostic and predictive marker in patients with lung cancer is widely debated. The aim of this review was to evaluate the results from studies made on this subject. Using the search words "CEA", "tumor markers in lung cancer", "prognostic significance", "diagnostic...... significance" and "predictive significance", a search was carried out on PubMed. Exclusion criteria was articles never published in English, articles before 1981 and articles evaluating tumor markers in lung cancer not involving CEA. Initially 217 articles were found, and 34 were left after selecting those...... relevant for the present study. Four of these included both Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) patients, and 31 dealt solely with NSCLC patients. Regarding SCLC no studies showed that serum level of CEA was a prognostic marker for overall survival (OS). The use of CEA...

  18. [Management of type 2 diabetes patients in community health care centers in Grenoble].

    Science.gov (United States)

    François, Patrice; Pichon, Philippe; Poulizac, Morgan; Cruaud, Anna; Bal, Gaelle; Hirsch, Martin

    2010-01-01

    Community health care centers in Grenoble aim to provide quality primary health care, including prevention, to populations living in disadvantaged urban areas. The objective of the study was to assess the quality of follow-up provided by physicians in health care centers in Grenoble to patients with diabetes mellitus. A cross-sectional study was conducted for an observation period of one week in june 2007. All type 2 diabetes patients seen in community health care centers during this given week were included in the study's sample (n=121). During the consultation, the physician collected the data on diabetes follow-up recorded in the patient's medical record over the last year. The data were compared with the recommendations and guidance published by the French National Authority for Health in 2006. The result of a hemoglobin A1c test dated less that three months-old was present in 80% of patients' medical records. Serum creatinine concentration, blood lipids, and microalbuminuria levels were obtained and confirmed with annual tests, and were present and recorded in the last year in 95%, 91%, and 77% of cases, respectively. The patient's weight, recorded within the last year, was noted in all cases. An ophthalmology consultation had been provided within the year for 57% of patients and 55% had received an electrocardiogram. Compliance with French National Authority for Health recommendations for the follow-up of diabetics in the community health care centers was satisfactory. Thus, it seems relevant to analyze their organizational methods.

  19. Report transparency and nuclear safety 2007 CEA Saclay; Rapport transparence et securite nucleaire 2007 CEA Saclay

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Saclay for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially two public consultation on release authorizations and the Neurospin installations, the dismantling of the 49 nuclear installation, the shutdown of the learning reactor ULYSSE are detailed. (A.L.B.)

  20. Report transparency and nuclear safety 2007 CEA Marcoule; Rapport transparence et securite nucleaire 2007 CEA Marcoule

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Marcoule for the year 2007. Since its creation in 1955 the center realizes industrial and scientific activities relative to the civil and military applications of the radioactivity. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the following two base activities are detailed: Atalante and Phenix. (A.L.B.)

  1. Report transparency and nuclear safety 2007 CEA Cadarache; Rapport transparence et securite nucleaire 2007 CEA Cadarache

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Cadarache for the year 2007. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. More especially the report discusses the beginning of the RJH reactor construction, the fourth generation reactors research programs, the implementing of la Rotonde the new radioactive wastes management installation, the renovation of the LECA. (A.L.B.)

  2. Neutron-capture experiment on {sup 78}Se with EXOGAM at ILL Grenoble

    Energy Technology Data Exchange (ETDEWEB)

    John, Robert; Massarczyk, Ralph; Schwengner, Ronald [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany); Blanc, Aurelien; Jentschel, Michael; Koester, Ulli; Mutti, Paolo; Urban, Waldemar [Institut Max von Laue - Paul Langevin, 38 - Grenoble (France); Belgya, Tamas [IKI Budapest (Hungary); Valenta, Stanislav [Karlova Univ., Prague (Czech Republic)

    2013-07-01

    We present first results of a neutron-capture study of {sup 78}Se. The experiment was carried out with cold neutrons at the reactor of the Institut Laue-Langevin (ILL) at Grenoble. Gamma rays following the {sup 77}Se(n, γ) reaction were measured with eight EXOGAM clover detectors, one clover detector taken from the Lohengrin setup and six GASP detectors. This setup enabled the measurement of two- and three-fold γ-ray coincidences as well as of angular correlations of the γ rays with high efficiency. The aim of the analysis is to gain detailed information about the deexcitation patterns of the capture state and lower-lying excited states. These may be used as a test for statistical simulations of γ-ray cascades and their inputs, such as γ-ray strength functions and level densities.

  3. Seismic Risk Scenario in Grenoble (FRANCE) Using Experimental Dynamic Properties of Buildings

    CERN Document Server

    Michel, Clotaire

    2007-01-01

    Assessing the vulnerability of a large set of buildings using sophisticated methods can be very time consuming and at a prohibitive cost, particularly for a moderate seismic hazard country like France. We propose here a low-cost analysis using an experimental approach to extract the elastic behaviour of existing buildings. An elastic modal model is proposed for the different types of building tested in Grenoble (France) thanks to their experimental modal parameters (resonance frequencies, modal shapes and damping), which are estimated using ambient vibrations surveys. Sixty buildings of various types were recorded. The building integrity is then calculated considering an accelerogram scenario provided by seismologists as input and considering an integrity threshold based on the FEMA inter-storey drift limits. Even if the level of damage remains unknown, we conclude that masonry buildings undergo more damage (70% of buildings damaged) than RC buildings. Finally, extracting modal parameters from ambient vibrati...

  4. Two cases of type A infant botulism in Grenoble, France: no honey for infants.

    Science.gov (United States)

    Hoarau, Gautier; Pelloux, Isabelle; Gayot, Armelle; Wroblewski, Isabelle; Popoff, Michel-Robert; Mazuet, Christelle; Maurin, Max; Croizé, Jacques

    2012-03-01

    We report two severe cases of infant botulism diagnosed at Grenoble University Hospital, France, respectively in 2006 and 2009. Both cases were characterized by a delay in diagnosis, severe neurological manifestations and extended period of hospitalization in intensive care unit, but a complete recovery. Infant botulism is a rare but life-threatening disease. It primarily affects infants, and the main risk factor is honey ingestion. Diagnosis should be systematically evoked by pediatricians in infants suffering from constipation, fatigue, muscle weakness, difficult feeding and altered cry, but before the onset of generalized flaccid paralysis, so as to administer specific treatment (BabyBIG®, a human derived botulinum antitoxin) at an early stage of the disease when it is most effective. In conclusion, parents should be aware of the role of honey as a source of spores of Clostridium botulinum and therefore infant botulism in the first year of life.

  5. Beam experiments with the Grenoble test electron cyclotron resonance ion source at iThemba LABS

    Energy Technology Data Exchange (ETDEWEB)

    Thomae, R., E-mail: rthomae@tlabs.ac.za; Conradie, J.; Fourie, D.; Mira, J.; Nemulodi, F. [iThemba LABS, P.O. Box 722, Somerset West 7130 (South Africa); Kuechler, D.; Toivanen, V. [CERN, BE/ABP/HSL, 1211 Geneva 23 (Switzerland)

    2016-02-15

    At iThemba Laboratory for Accelerator Based Sciences (iThemba LABS) an electron cyclotron ion source was installed and commissioned. This source is a copy of the Grenoble Test Source (GTS) for the production of highly charged ions. The source is similar to the GTS-LHC at CERN and named GTS2. A collaboration between the Accelerators and Beam Physics Group of CERN and the Accelerator and Engineering Department of iThemba LABS was proposed in which the development of high intensity argon and xenon beams is envisaged. In this paper, we present beam experiments with the GTS2 at iThemba LABS, in which the results of continuous wave and afterglow operation of xenon ion beams with oxygen as supporting gases are presented.

  6. [Computer-assisted total knee arthroplasty: 12 years experience in Grenoble].

    Science.gov (United States)

    Saragaglia, Dominique

    2009-01-01

    Computer-assisted total knee arthroplasty was developed in Grenoble in the mid-1990s. The first human implantation was performed on 21 January 1997, with no particular problems. Since this date more than 200,000 patients have been implanted with our device all over the world. The device is passive (not active like a robot), and requires no pre- or perioperative imaging. It is based on kinematics and palpation, the surgeon remaining in charge at all times. The computer helps to identify the lower leg axis, to accurately fix the bone cutting guides, and to check the ligament balance. These steps are not easy to perform with conventional ancillaries. The effectiveness of computer-assisted total knee replacement is well documented, although it is too early to claim that a "well-aligned" prothesis will have a better survival rate. Long-term follow-up studies are needed, with modern prostheses, to confirm the results of historical studies.

  7. [Computerized medical register of venous thromboembolic disease at the Grenoble University Hospital Center: description and evaluation].

    Science.gov (United States)

    Michoud, E; Bosson, J L; Pichot, O; Vidal, F; Rossignol, S; Schwartzmann, J; Carpentier, P H

    1994-01-01

    The number of vascular exams for venous thromboembolic disease increases dramatically in the vascular medicine unit at the Grenoble University Hospital (France). In order to improve the efficiency and the homogeneity of all the medical staff involved, a computerized register has been created. It automatically provides a letter for the prescriber of the consultation. This database, working on a computer network, has three main functions: office automation (medical folder, report), education, and clinical research. The office automation evaluation is performed after a 6 month experience, comparing 100 medical reports about venous thrombosis assisted by the computer to 100 medical reports written before the installation of the system. The introduction of digitized register is real, still this evaluation has induced some modification in the system in order to be more efficient.

  8. Beam experiments with the Grenoble test electron cyclotron resonance ion source at iThemba LABS

    Science.gov (United States)

    Thomae, R.; Conradie, J.; Fourie, D.; Mira, J.; Nemulodi, F.; Kuechler, D.; Toivanen, V.

    2016-02-01

    At iThemba Laboratory for Accelerator Based Sciences (iThemba LABS) an electron cyclotron ion source was installed and commissioned. This source is a copy of the Grenoble Test Source (GTS) for the production of highly charged ions. The source is similar to the GTS-LHC at CERN and named GTS2. A collaboration between the Accelerators and Beam Physics Group of CERN and the Accelerator and Engineering Department of iThemba LABS was proposed in which the development of high intensity argon and xenon beams is envisaged. In this paper, we present beam experiments with the GTS2 at iThemba LABS, in which the results of continuous wave and afterglow operation of xenon ion beams with oxygen as supporting gases are presented.

  9. Beam experiments with the Grenoble test electron cyclotron resonance ion source at iThemba LABS.

    Science.gov (United States)

    Thomae, R; Conradie, J; Fourie, D; Mira, J; Nemulodi, F; Kuechler, D; Toivanen, V

    2016-02-01

    At iThemba Laboratory for Accelerator Based Sciences (iThemba LABS) an electron cyclotron ion source was installed and commissioned. This source is a copy of the Grenoble Test Source (GTS) for the production of highly charged ions. The source is similar to the GTS-LHC at CERN and named GTS2. A collaboration between the Accelerators and Beam Physics Group of CERN and the Accelerator and Engineering Department of iThemba LABS was proposed in which the development of high intensity argon and xenon beams is envisaged. In this paper, we present beam experiments with the GTS2 at iThemba LABS, in which the results of continuous wave and afterglow operation of xenon ion beams with oxygen as supporting gases are presented.

  10. [Mental health, vulnerability and general practice: a study of non-profit health centers in Grenoble].

    Science.gov (United States)

    Dubois-Fabing, Delphine; Pichon, Philippe; Arnevielhe, Alizée; Suscillon, Marie-Paule; Caron, Bruno; Saillard, Fabienne; François, Patrice

    2011-01-01

    Very little research has been conducted on the role of general practitioners (GPs) in mental health care among socioeconomically disadvantaged populations in France. The non-profit community health care centers in Grenoble provide populations living in sensitive urban zones with high quality primary health care that includes a medico-social and prevention dimension. The aim of this study was to measure the prevalence of mental health issues diagnosed by GPs in health care centers, to identify the factors associated with these issues and to describe treatment characteristics. This cross-sectional study focused on general practice consultations in the AGECSA Grenoble health care centers over the course of one week. At the end of each consultation, the GP collected information about the patient, including personal data, psychological disorders, vulnerability, and patient health management. Among the 451 patients included in the study, GPs found that 45.2% of patients were in vulnerable situations and 43% of patients suffered from a mental disorder, including 29% of cases of anxiety and 20% of cases of depression. 44% of patients suffered from a psychological disorder (mental disorder and/or psychological suffering). For these patients, 52.8% of the consultations lasted more than 20 minutes. Their treatment generally included a mental health care follow-up (in 76% of cases), including psychological support (59%) and treatment of functional somatic disorders (46%). The study shows the high prevalence of psychological disorders diagnosed in the patients treated by GPs working in health care centers in disadvantaged urban areas. Research shows that GPs play an important and specific role in mental health care and prevention. An analysis of the organizational methods used in health care centers is highly relevant.

  11. Summer/winter variability of the surfactants in aerosols from Grenoble, France

    Science.gov (United States)

    Baduel, Christine; Nozière, Barbara; Jaffrezo, Jean-Luc

    2012-02-01

    Many atmospheric aerosols seem to contain strong organic surfactants likely to enhance their cloud-forming properties. Yet, few techniques allow for the identification and characterization of these compounds. Recently, we introduced a double extraction method to isolate the surfactant fraction of atmospheric aerosol samples, and evidenced their very low surface tension (≤30 mN m -1). In this work, this analytical procedure was further optimized. In addition to an optimized extraction and a reduction of the analytical time, the improved method led to a high reproducibility in the surface tension curves obtained (shapes and minimal values), illustrated by the low uncertainties on the values, ±10% or less. The improved method was applied to PM 10 aerosols from the urban area of Grenoble, France collected from June 2009 to January 2010. Significant variability was observed between the samples. The minimum surface tension obtained from the summer samples was systematically lower (30 mN m -1) than that of the winter samples (35-45 mN m -1). Sharp transitions in the curves together with the very low surface tensions suggested that the dominating surfactants in the summer samples were biosurfactants, which would be consistent with the high biogenic activity in that season. One group of samples from the winter also displayed sharp transitions, which, together with the slightly higher surface tension, suggested the presence of weaker, possibly man-made, surfactants. A second group of curves from the winter did not display any clear transition but were similar to those of macromolecular surfactants such as polysaccharides or humic substances from wood burning. These surfactants are thus likely to originate from wood burning, the dominating source for aerosols in Grenoble in winter. These observations thus confirm the presence of surfactants from combustion processes in urban aerosols reported by other groups and illustrates the ability of our method to distinguish between

  12. El acné y la rosácea

    OpenAIRE

    Rueda Plata, Ricardo A.; Fundación Valle de Lili

    2001-01-01

    Acné/ ¿Qué es el acné?/ ¿Cómo se forma el acné?/ ¿Qué otros factores influyen?/ ¿El acné de los adolescentes o acné vulgar es la única forma de la enfermedad?/ ¿Cómo se trata el acné?/ ¿Qué cuidados debo tener?/ ¿Qué es la rosácea?/ ¿cómo es y como evoluciona la rosácea?/ ¿Qué personas están más predispuestas a la rosácea?/ ¿Qué otros factores influyen?/ ¿Qué hacer y que evitar?/ ¿Cómo se trata la rosácea?

  13. ECR Light Ion Sources at CEA/Saclay%CEA/Saclay的ECR轻离子离子源

    Institute of Scientific and Technical Information of China (English)

    R.Gobin; P-A.Leroy; O.Tuske; D.Uriot; P-Y.Beauvais; A.Ben Ismail; D.Bogard; O.Delferriere; D.de Menezes; R.Duperrier; Y.Gauthier; F.Harrault

    2007-01-01

    In the beginning of the 90s,T.Taylor and his collaborators demonstrated ECR sources operating at low frequency (I.e.2.45GHz) are able to produce very intense single charge light ion beams.At CEA/Saclay,the SILHI source developments started in 1995.Since 1997 more than 100mA proton or deuteron beams are routinely produced in pulsed or continuous mode.To comply with ADS reliability constraint,important improvements have been performed to increase the installation reliability.Moreover,to optimize the beam transport in the low energy beam line,the extraction system was carefully designed and space charge compensation studies were undertaken.An important step has been reached in 2005 with the development of a permanent magnet source able to produce a total beam of 109mA at 85kV.A new test bench named BETSI,especially dedicated to permanent magnet source developments,is presently under construction.It will allow analysing positive or negative extracted beams up to 50keV and 100mA.In addition,for several years work has been done to optimize the production of negative hydrogen ion beam with such an ECR source.Recent analysis pushed towards the construction of a new set up based on a multicusp magnetic configuration.After a brief overview of the CEA/Saclay source developments,this article will point out on the recent results and present status.

  14. The use and evolution of the CEA research reactors; Utilisation et evolution des reacteurs de recherche du C.E.A

    Energy Technology Data Exchange (ETDEWEB)

    Rossillon, F.; Chauvez, C. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    The authors successively examine the different research reactors in use in the French C.E.A. Nuclear Centres. They trace briefly their histories, describing how they have been used up to the present, and how they have been adapted to changes in programme by means of certain modifications. They also describe the reasons which have led to the elaboration of the project for the new reactor Osiris. Zoe, the oldest reactor in the CEA, has been in service in the Centre de Fontenay-aux-Roses since 1948. It is used mainly for measurements of absorption cross-sections in graphite, and for various short irradiations which do not require high fluxes. The reactor EL 2, in service since 1952, was used for the first studies on gas cooling. It has also been widely used for the production of radioisotopes and for a large number of experiments in the fields of physics, metallurgy and physical chemistry. The ageing of certain elements of the reactor has led to the decision to close it down in the near future The reactor EL 3 has been widely used for experiments in physics and in the investigation of fuels. The possibilities of the reactor in fast neutron irradiations will be considerably improved by the adoption of a new type of core (the 'snow crystal' structure). Triton-I, a 2 MW swimming-pool reactor, is used for the most part for fast neutron and gamma irradiations. The modifications being carried out on it at present should result in an increase in the power of the reactor up to 4 or 5 MW. In a neighbouring compartment is housed Triton-II which is of the same general structure, as Triton-I, but whose maximum power is 100 kW. Triton-II is used solely for studies on shielding. Melusine, a 2 MW swimming-pool reactor, has been in use in the Centre d'Etudes Nucleaires de Grenoble since 1959. It has supported a very high programme concerned mainly with solid state physics, fundamental research into refractory fissile materials and special graphites, and the study of

  15. CEA Saclay Center. 2009 environmental assessment; Centre CEA de Saclay. Bilan environnemental 2009

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This report indicates the sampling places and frequency of environment controls around the CEA Saclay Centre. These samplings concern surface waters, rain waters, fruits and vegetables, milk, underground waters, air and grass. It indicates the authorized levels of gaseous releases by nuclear installations, the measured values of liquid and gaseous effluent releases with respect to these levels. It comments these results, i.e. those observed, for air quality, and for surface and underground waters, and for bio-indicators (presence of tritium in food chain products like milk, grass, fruits and vegetables). It comments the annual radiological impact which is established with respect to annual radioactive releases. It briefly comments the evolution of tritium releases over the years (since 1954). The new gaseous and liquid effluent release authorization levels are compared with those of 1978

  16. Analyse des dynamiques paysagères dans le bassin de vie de Grenoble entre 1998 et 2009

    OpenAIRE

    Vannier, Clémence; Lasseur, Rémy; Lavorel, Sandra; Lefebvre, Jérémie; Nettier, Baptiste; Longaretti, Pierre-Yves

    2016-01-01

    We present a landscape dynamic analysis between 1998 and 2009 in the Grenoble catchment area, around 4450 km². We produced a detailed mapping for 1998, 2003 and 2009 using the merging of heterogeneous public data (in terms of spatial resolution and typology), remote sensing classification and photointerpretation. We produced a detailed mapping for agricultural area practices too, using multitemporal remote-sensing classification.Results showed, during the 1998-2009 period, a rapid urban growt...

  17. [Mountain sports: their role in 2200 facial injuries occurring over 4 years at the University Hospital Center in Grenoble].

    Science.gov (United States)

    Le Bescond, Y; Lebeau, J; Delgove, L; Sadek, H; Raphael, B

    1992-01-01

    Injuries caused by mountain sports account for many of the injuries admitted to the University Hospital of Grenoble. Out of 4,490 traumas, 470 were injuries sustained during the practice of mountain sports. While the frequency of these accidents does not evolve much, the etiological distribution depends on fashion. Thus an increasing number of lesions caused by cross-country biking has been noted during the past two years. We find it urgent to propose protective measures adapted to this new sport.

  18. [Drug supply chain safety in hospitals: current data and experience of the Grenoble university hospital].

    Science.gov (United States)

    Bedouch, P; Baudrant, M; Detavernier, M; Rey, C; Brudieu, E; Foroni, L; Allenet, B; Calop, J

    2009-01-01

    Drug supply chain safety has become a priority for public health which implies a collective process. This process associates all health professionals including the pharmacist who plays a major role. The objective of this present paper is to describe the several approaches proven effective in the reduction of drug-related problem in hospital, illustrated by the Grenoble University Hospital experience. The pharmacist gets involved first in the general strategy of hospital drug supply chain, second by his direct implication in clinical activities. The general strategy of drug supply chain combines risk management, coordination of the Pharmacy and Therapeutics Committee, selection and purchase of drugs and organisation of drug supply chain. Computer management of drug supply chain is a major evolution. Nominative drug delivering has to be a prior objective and its implementation modalities have to be defined: centralized or decentralized in wards, manual or automated. Also, new technologies allow the automation of overall drug distribution from central pharmacy and the implementation of automated drug dispensing systems into wards. The development of centralised drug preparation allows a safe compounding of high risk drugs, like cytotoxic drugs. The pharmacist should develop his clinical activities with patients and other health care professionals in order to optimise clinical decisions (medication review, drug order analysis) and patients follow-up (therapeutic monitoring, patient education, discharge consultation).

  19. [Temporary vena caval filters: report on cohort of 72 patients in Grenoble, France].

    Science.gov (United States)

    Seinturier, C; Dornier, C; Thony, F; Blaise, S; Rodière, M; Menez, C; Arnoult, A-C; Imbert, B; Pernod, G

    2013-12-01

    Patients with a contra-indication for anticoagulation can benefit from temporary vena caval filters for protection against pulmonary embolism or recurrence. The filter can be removed secondarily, once the contra-indication is overcome, enabling better long-term outcome by reducing the risk of thrombotic and mechanic complications inherent in these devices. However, it has been shown in several studies that effective withdrawal rates were low and could be improved by the establishment of protocols and registries. We report a retrospective study of withdrawal in 72 patients in whom an ALN® vena caval filter was implanted at the Grenoble University Hospital over a period of three years with an intention for secondary retrieval. Seventy percent of the indications were related to the coexistence of thrombotic and hemorrhagic conditions. Fifty-five percent of filters were removed, the remaining 45% shared involved patients who died before retrieval (11%), those lost to follow-up (4%), technical failure of retrieval (6%), withdrawal technically unfeasible (3%), retrieval refused by patients (6%) and medical indications for continuing filtration (15%). Despite an effective follow-up of these patients and 91% success rate of withdrawal, nearly one out of two filters remains in place. A long-term follow-up of these patients is needed to learn more about the outcome of these filters.

  20. [Incidents of brain tumors observed in the Grenoble area (canton of Meylan) 1979-1990].

    Science.gov (United States)

    Orfeuvre, H; Lutz, J M; Menegoz, F; Exbrayat, C; Colonna, M; Schaerer, R

    1993-01-01

    A high excess of risk (standardized incidence ratio S.I.R.: 320 [190-490]) of intracranial tumors among men living within the county of Meylan, in the suburb area of Grenoble, as compared with the overall population was shown by the Isère Cancer Registry, for the period 1979-1984. There has been no change of this excess of risk between 1979 and 1990 (S.I.R. = 190). The pathological homogeneity of this cluster (neuroglial tumors) among men is noticeable. This county is known as a concentration of high-tech and intellectual professional activities. A descriptive study was conducted on the 24 cases diagnosed between 1979 and 1990, based on retrospective interviews of patient's family. Ethnical origins, blood groups, personal and familial medical history (with special interest in cranial injuries), socio economic status, chemicals, radiations and electro-magnetic exposures, acoustic and visual exposures (such as noises and T.V.), drinking water, tobacco and food consumptions, were investigated. Educational level, occupation, and European ethnic origin are all pointing to the same direction: a higher risk in high level social classes and high level professions. An analytical study is going on, that would give a deeper insight in these phenomenons.

  1. Influence of anthropogenic sources on total gaseous mercury variability in Grenoble suburban air (France).

    Science.gov (United States)

    Dommergue, Aurélien; Ferrari, Christophe P; Planchon, Frédéric A M; Boutron, Claude F

    2002-10-07

    Total gaseous mercury (TGM) has been monitored at Champ sur Drac, a suburban site of Grenoble in southern east France. TGM measurements have been made over 4 periods of approximately 10 days throughout 1999-2000 using cold vapour atomic fluorescence absorption technique. The first monitoring campaign was initiated on November 4, 1999, followed by three other campaigns respectively on January 12, 2000, April 10, 2000 and July 17, 2000. Concurrent monitoring of O3, NO, NO2, SO2 and of meteorological parameters have also been performed. The mean TGM concentration was 3.4 ng m(-3) with maximum hourly mean concentration of 37.1 ng m(-3). Although mean TGM concentration was not greatly different from those previously measured in the troposphere, the greater TGM variability as well as the occurrence of high TGM concentration linked to particular wind conditions suggested the strong influence of anthropogenic sources. The chlor-alkali plant located nearby, the others chemical industries using fuel combustion and the municipal waste incinerator were thought to contribute to mercury pollution events.

  2. An investigation of ozone and planetary boundary layer dynamics over the complex topography of Grenoble combining measurements and modeling

    Directory of Open Access Journals (Sweden)

    O. Couach

    2003-01-01

    Full Text Available This paper concerns an evaluation of ozone (O3 and planetary boundary layer (PBL dynamics over the complex topography of the Grenoble region through a combination of measurements and mesoscale model (METPHOMOD predictions for three days, during July 1999. The measurements of O3 and PBL structure were obtained with a Differential Absorption Lidar (DIAL system, situated 20 km south of Grenoble at Vif (310 m ASL. The combined lidar observations and model calculations are in good agreement with atmospheric measurements obtained with an instrumented aircraft (METAIR. Ozone fluxes were calculated using lidar measurements of ozone vertical profiles concentrations and the horizontal wind speeds measured with a Radar Doppler wind profiler (DEGREANE. The ozone flux patterns indicate that the diurnal cycle of ozone production is controlled by local thermal winds. The convective PBL maximum height was some 2700 m above the land surface while the nighttime residual ozone layer was generally found between 1200 and 2200 m. Finally we evaluate the magnitude of the ozone processes at different altitudes in order to estimate the photochemical ozone production due to the primary pollutants emissions of Grenoble city and the regional network of automobile traffic.

  3. 2nd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Mulder, Bob; Choukroun, Daniel; Kampen, Erik-Jan; Visser, Coen; Looye, Gertjan

    2013-01-01

    Following the successful 1st CEAS (Council of European Aerospace Societies) Specialist Conference on Guidance, Navigation and Control (CEAS EuroGNC) held in Munich, Germany in 2011, Delft University of Technology happily accepted the invitation of organizing the 2nd  CEAS EuroGNC in Delft, The Netherlands in 2013. The goal of the conference is to promote new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems using on-board sensing, computing and systems. A great push for new developments in GNC are the ever higher safety and sustainability requirements in aviation. Impressive progress was made in new research fields such as sensor and actuator fault detection and diagnosis, reconfigurable and fault tolerant flight control, online safe flight envelop prediction and protection, online global aerodynamic model identification, online global optimization and flight upset recovery. All of these challenges de...

  4. CEA 2011, a look back at a year of research

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    For this year 2011, marked by the Fukushima accident, the goal is improved safety. This is a key issue being addressed by CEA, while at the same time boosting its R and D on low-carbon energies, defense and security, Health technologies, information technologies and very large research Infrastructures. With more than 650 priority patents filed in 2011, CEA maintains its position as the leading French research organization. CEA stands in 4. place among the European research organizations, in terms of the number of projects (535, including 70 that it coordinates) and financing obtained (nearly euros 55 M) under the European Commission's FP7 framework programme. CEA's civil programs are 30% funded from external revenues (partner companies, national incentive funds, local authorities and European Union), 49% from the Government and, finally, 21% from two funds dedicated to clean-up of civil and defense facilities. Of the euros 1, 391 M devoted to low-carbon energies, research into the new energy technologies and nuclear systems of the future each received a budget of euros 151 M in 2011. CEA plays a key role in the European Energy Research Alliance, as a founding member, a member of the executive committee and a member of the secretariat. It is France's representative. EERA has launched 13 joint programs, including 6 in 2011. It pools the research efforts of more than 150 institutes and universities, with more than 2, 000 staff employed full-time. CEA is present in 8 programs, with 100 full-time staff, in other words 5% of the total partner commitment. This special issue of 'Defis du CEA' journal deals with the main results of the researches carried out in 2011 at the CEA. Contents: 1 - Facts and figures 2011: Intellectual Property, European Financing, Budget, Nuclear Safety, European Research Programs, International Relations, International Collaboration, Spin-off, Scientific Excellence, Training; 2 - Low-carbon energies: Biofuels, Solar

  5. Complete solid state lighting (SSL) line at CEA LETI

    Science.gov (United States)

    Robin, I. C.; Ferret, P.; Dussaigne, A.; Bougerol, C.; Salomon, D.; Chen, X. J.; Charles, M.; Tchoulfian, P.; Gasse, A.; Lagrange, A.; Consonni, M.; Bono, H.; Levy, F.; Desieres, Y.; Aitmani, A.; Makram-Matta, S.; Bialic, E.; Gorrochategui, P.; Mendizabal, L.

    2014-09-01

    With a long experience in optoelectronics, CEA-LETI has focused on Light Emitting Diode (LED) lighting since 2006. Today, all the technical challenges in the implementation of GaN LED based solid state lighting (SSL) are addressed at CEA-LETI who is now an RandD player throughout the entire value chain of LED lighting. The SSL Line at CEA-LETI first deals with the simulation of the active structures and LED devices. Then the growth is addressed in particular 2D growth on 200 mm silicon substrates. Then, technological steps are developed for the fabrication of LED dies with innovative architectures. For instance, Versatile LED Array Devices are currently being developed with a dedicated μLED technology. The objective in this case is to achieve monolithical LED arrays reported and interconnected through a silicon submount. In addition to the required bonding and 3D integration technologies, new solutions for LED chip packaging, thermal management of LED lamps and luminaires are also addressed. LETI is also active in Smart Lighting concepts which offer the possibility of new application fields for SSL technologies. An example is the recent development at CEA LETI of Visible Light Communication Technology also called LiFi. With this technology, we demonstrated a transmission rate up to 10 Mb/s and real time HD-Video transmission.

  6. Stromal CEA immunoreactivity is correlated with lymphatic invasion of human esophageal carcinoma.

    Science.gov (United States)

    Kijima, H; Oshiba, G; Kenmochi, T; Kise, Y; Tanaka, H; Chino, O; Shimada, H; Ueyama, Y; Tanaka, M; Makuuchi, H

    2000-04-01

    Carcinoembryonic antigen (CEA) is a good marker of colorectal cancer. Recent studies have demonstrated that CEA may function as a metastatic potentiator by different pathways; i.e. modulation of immune responses, facilitation of intercellular adhesion and cellular migration. However, expression patterns of CEA have not yet been established in human esophageal carcinomas. In this study, we examined CEA expression in human esophageal squamous cell carcinoma and its clinicopathological significance. CEA immunoreactivity was frequently detected in the cancer cells (cytoplasmic type; 81.1%, 43/53) as well as in the cancer stroma (stromal type; 32.1%, 17/53), regardless of the depth of tumor invasion. Lymphatic invasion of cancer cells was frequently found in the stromal CEA-positive esophageal cancer (44.4%, 16/36), compared to stromal CEA-negative cancer (5.9%, 1/17) (pCEA expression plays important roles in lymphatic invasion of human esophageal squamous cell carcinoma.

  7. Comparison between seismic and domestic risk in moderate seismic hazard prone region: the Grenoble City (France test site

    Directory of Open Access Journals (Sweden)

    F. Dunand

    2012-02-01

    Full Text Available France has a moderate level of seismic activity, characterized by diffuse seismicity, sometimes experiencing earthquakes of a magnitude of more than 5 in the most active zones. In this seismicity context, Grenoble is a city of major economic and social importance. However, earthquakes being rare, public authorities and the decision makers are only vaguely committed to reducing seismic risk: return periods are long and local policy makers do not have much information available. Over the past 25 yr, a large number of studies have been conducted to improve our knowledge of seismic hazard in this region. One of the decision-making concerns of Grenoble's public authorities, as managers of a large number of public buildings, is to know not only the seismic-prone regions, the variability of seismic hazard due to site effects and the city's overall vulnerability, but also the level of seismic risk and exposure for the entire city, also compared to other natural or/and domestic hazards. Our seismic risk analysis uses a probabilistic approach for regional and local hazards and the vulnerability assessment of buildings. Its applicability to Grenoble offers the advantage of being based on knowledge acquired by previous projects conducted over the years. This paper aims to compare the level of seismic risk with that of other risks and to introduce the notion of risk acceptability in order to offer guidance in the management of seismic risk. This notion of acceptability, which is now part of seismic risk consideration for existing buildings in Switzerland, is relevant in moderately seismic-prone countries like France.

  8. [Epidemic of autochthonous hepatic and intestinal amebiasis in a place near Grenoble].

    Science.gov (United States)

    Ambroise-Thomas, P; Goullier, A; Grillot, R; Lascaud, D; Rivoire, L; Perrin, Y

    1975-01-01

    We had the opportunity of studying an epidemic of autochthonous amoebiasis occurring in the autumn of 1974 in a small town of 4000 inhabitants 30 km from Grenoble. Attention was originally attracted by the occurrence in this town of two cases of hepatic amoebiasis and one of intestinal amoebiasis identified by rectoscopy. Systematic investigations (coproctic examinations and serological tests for amoebiasis by indirect antibody fluorescence) were then carried out on everyone in the locality with digestive disorders which were possibly referable to amoebiasis, and on the other members of their families. A total number of 148 coproctic examinations were made and in two cases revealed the presence of vegetative forms of Entamoeba histolytica. In both cases the infestation provoked few symptoms (asthenia, vague abdominal discomfort, intermittent and apparently banal diarrhoea). On the other hand 20 out of 94 serological tests revealed positive results, 14 of which were equal to or greater than a titre of 1/100, a level at which all risks of non-specificity are virtually ruled out under our experimental conditions. Material reasons made it impossible to subject these cases to repeated faecal checks, but in two of them at least the rectoscopic appearances were very suggestive of subacute intestinal amoebiasis. Moreover, amoebic disease appears to be well confirmed by the results obtained among the patients as a whole by treatment with Metroinidazole. A variety of hypotheses on the origin of this epidemic have been put forward and then abandoned (market garden produce, receipt by certain families of exotic frut from overseas). In actual fact water seems to be the point of departure, for, although specimens of water taken at 7 different levels in the water supply system failed to reveal the presence of a single amoeba, bacteriological analyses during autumn 1974 showed signs of faecal contamination. The locality, which is situated at the foot of the Chartreuse massif

  9. Serum sialic acid and CEA concentrations in human breast cancer.

    Science.gov (United States)

    Hogan-Ryan, A; Fennelly, J J; Jones, M; Cantwell, B; Duffy, M J

    1980-04-01

    The concentration of bound sialic acid in the sera of 56 normal subjects and 65 subjects with breast cancer was measured, in order to determine (1) whether serum sialic acid concentrations are raised in breast cancer and (2) whether the concentration of sialic acid in serum reflects tumour stage. The amount of sialic acid in serum was compared to serum carcinoembryonic antigen (CEA) values. Urinary hydroxyproline and serum alkaline phosphatase concentrations were used as indicators of bone and liver involvement. Erythrocyte sedimentation rate (ESR) was also measured. Significantly elevated serum sialic acid concentrations were found in breast cancer, and showed correlation with tumour stage. Serum sialic acid values did not correlate with CEA values. The results suggest that measurement of serum sialic acid concentrations may be of adjunctive value in assessing tumour stage.

  10. Annual report of the Association EURATOM/Cea

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, Ph.; Le Vagueres, F

    2002-07-01

    This annual report presents research activities, which have been performed in 2002 by the French EURATOM-Cea association in the frame of the European technology program. The first section describes EFDA (European fusion development agreement) activities and related developments carried out by the association. The second one is dedicated to the underlying technology program and finally the third one presents the inertial confinement fusion activities. In each section the tasks are sorted out according to the EFDA main fields: physics (heating and current drive, remote participation, diagnostics), vessel/in-vessel (vessel/blanket, plasma facing components, remote handling), magnet, tritium breeding and materials (water cooled lithium lead blanket, helium cooled pebble bed blanket, helium cooled lithium lead blanket, reduced activation ferritic martensitic steels, advanced materials, neutron source, fuel cycle), safety and environment, system studies (power plant conceptual studies, socio-economic studies) and JET technology activities. The EURATOM-Cea association is involved in all these studies.

  11. Serum sialic acid and CEA concentrations in human breast cancer.

    OpenAIRE

    Hogan-Ryan, A.; Fennelly, J J; Jones, M.; Cantwell, B; Duffy, M J

    1980-01-01

    The concentration of bound sialic acid in the sera of 56 normal subjects and 65 subjects with breast cancer was measured, in order to determine (1) whether serum sialic acid concentrations are raised in breast cancer and (2) whether the concentration of sialic acid in serum reflects tumour stage. The amount of sialic acid in serum was compared to serum carcinoembryonic antigen (CEA) values. Urinary hydroxyproline and serum alkaline phosphatase concentrations were used as indicators of bone an...

  12. Potent and specific antitumor effect of CEA-targeted photoimmunotherapy.

    Science.gov (United States)

    Shirasu, Naoto; Yamada, Hiromi; Shibaguchi, Hirotomo; Kuroki, Motomu; Kuroki, Masahide

    2014-12-01

    Conventional photodynamic therapy (PDT) for cancer is limited by the insufficient efficacy and specificity of photosensitizers. We herein describe a highly effective and selective tumor-targeted PDT using a near-infrared (NIR) photosensitizer, IRDye700DX, conjugated to a human monoclonal antibody (Ab) specific for carcinoembryonic antigen (CEA). The antitumor effects of this Ab-assisted PDT, called photoimmunotherapy (PIT), were investigated in vitro and in vivo. The Ab-IRDye conjugate induced potent cytotoxicity against CEA-positive tumor cells after NIR-irradiation, whereas CEA-negative cells were not affected at all, even in the presence of excess photoimmunoconjugate. We found an equivalent phototoxicity and a predominant plasma membrane localization of Ab-IRDye after both one and six hours of incubation. Either no or little caspase activation and membrane peroxidation were observed in PIT-treated cells and a panel of scavengers for reactive oxygen species showed only partial inhibition of the phototoxic effect. Strikingly, Ab-IRDye retained significant phototoxicity even under hypoxia. We established a xenograft model, which allowed us to sensitively investigate the therapeutic efficacy of PIT by non-invasive bioluminescence imaging. Luciferase-expressing MKN-45-luc human gastric carcinoma cells were subcutaneously implanted into both flanks of nude mice. NIR-irradiation was performed for only the tumor on one side. In vivo imaging and measurement of the tumor size revealed that a single PIT treatment, with intraperitoneal administration of Ab-IRDye and subsequent NIR-irradiation, caused rapid cell death and significant inhibition of tumor growth, but only on the irradiated side. Together, these data suggest that Ab-IRDye-mediated PIT has great potential as an anticancer therapeutics targeting CEA-positive tumors.

  13. Innovaciones en el agrodesarrollo de las cactáceas

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Padrón Pereira

    2012-01-01

    Full Text Available La globalización de los mercados ofrece nuevas oportunidades de desarrollo del campo en especial a recursos subutilizados en algunos países como las cactáceas, debido en parte a que, en cada país, los modelos culturales y de cultivo son diferentes. El cambio climático está generando nuevas dinámicas en dichos modelos que pueden llegar a ser sostenibles o disruptivas y las cáctaceas se presentan en ciertos aspectos como alternativas para la sustentabilidad de algunos sistemas; aunque también pueden verse afectadas. Lo expresado genera estudios diversos y en distintas especialidades. En este trabajo se presenta una recopilación de información existente y actualizada sobre temas relacionados con el aprovechamiento, la morfoanatomía, la germinación y desarrollo de las cactáceas, el cultivo in vitro, como también aspectos relativos a parámetros fisicoquímicos, la poscosecha y una reseña sobre cactáceas epífitas y/o trepadoras, las menos estudiadas.

  14. [Levels of lead, cadmium and mercury in the hair of inhabitants of the Nantes and Grenoble areas].

    Science.gov (United States)

    Boiteau, H L; Stoklov, M; Remond, D; Buffet, H; Metayer, C; Vincent, F; Corneteau, H; Faure, J

    1983-11-01

    Lead, cadmium and mercury were measured in the air of 398 inhabitants of the Grenoble area and 341 inhabitants of the Nantes area. The hair was washed with hor solution of EDTA, dissolved in nitric acid and analyzed by electrothermal atomic absorption spectrometry. The average concentrations are 6,23 micrograms/g for lead, 0,40 microgram/g for cadmium and 1,06 microgram/g for mercury. There is no difference between found data of the two areas for lead and cadmium. Mercury levels are higher in the Nantes area. Lead content is higher in male hair than in female hair, but the difference is not significant. In the Grenoble area, mercury levels are higher in males than in females; the process is reversed in the Nantes area. We have found no relation between metal levels and age of persons, but lead content is high in the hair of people under ten. Artisans and mechanics have lead content higher than the general people, though exposed people to occupational risks is excluded. We have found to relation between metal in the hair and the size of the town. It seems that the use of tobacco is without influence. Mercury content is related to the eating of fish. It is not increased in the population because of dental amalgams.

  15. Rosácea fulminante: relato de caso

    Directory of Open Access Journals (Sweden)

    José Otávio Alquezar Gozzano

    2016-10-01

    Full Text Available Introdução: Rosácea fulminante (RF ou pioderma facial é uma doença rara, descrita em 1940 por Kierland e O’Leary. É considerada uma variante extrema de rosácea conglobata, esta, consiste em formação de placas e abscessos hemorrágicos na pele. A RF tem sua etiologia desconhecida, porém há teorias que relacionam seu acometimento com a variação de hormônios femininos e a ingestão de vitamina B12. A RF é frequente em mulheres, principalmente pós- adolescentes. Apresenta-se abruptamente na face, amiúde na região mento- mandibular, através de pápulas inflamatórias, pústulas, cistos e nódulos com comedões escassos ou inexistentes, além de abcessos, sem manifestações sistêmicas e com a recidiva rara. Seu diagnóstico é fundamentalmente clínico, apenas com a história do paciente, sem necessidade de exames complementares. Para o tratamento, são utilizados corticoides orais, isotretinoína oral e antibióticos a fim de minimizar as sequelas físicas e psicológicas. Objetivo: Relatar caso de paciente com diagnóstico de rosácea fulminante. Metodologia: Paciente diagnosticada com rosácea fulminante atendida em serviço ambulatorial e revisão de literatura. Relato de caso: Paciente do sexo feminino, 19 anos, refere lesões súbitas em face há uma semana. Nega quadro acneico anterior, histórias de alergias e outras comorbidades. Relata ausência de uso de anticoncepcionais orais há 5 meses e data de última menstruação há 3 semanas, sem atraso menstrual. Ao exame: pápulas eritematosas e pústulas, além de pequenos nódulos inflamatórios na face. Hipótese diagnóstica: RF. Como conduta, foi prescrito tetraciclina. Conclusões: A RF é uma forma infrequente de rosácea, sendo importante o diagnóstico precoce e tratamento eficaz, a fim de melhorar a qualidade de vida do paciente.

  16. [Dietary behavior of the Middle Ages in Grenoble: application of isotopic biogeochemistry of the Saint-Laurent cemetery (XIIIth-XVth centuries, Isère, France)].

    Science.gov (United States)

    Herrscher, E; Bocherens, H; Valentin, F; Colardelle, R

    2001-05-01

    Isotopic analysis of 13C and 15N of 47 bones from Saint-Laurent de Grenoble cemetery (Grenoble, Isère), from the end of medieval period (XIIIth-XVth centuries AD) allowed to define the food status of animals with regard to the humans and to discuss the variability amongst adults. Adults who died young and those with small stature may have had diets poor in animal protein. The consumption of animal proteins was more important in the XVth than in the XIVth century and could illustrate a typical urban food economy providing its population with a more diversified diet than in rural areas.

  17. DEUXIEME CONFERENCE INTERNATIONALE SUR LE TRAITEMENT AUTOMATIQUE DES LANGUES (SECOND INTERNATIONAL CONFERENCE ON COMPUTATIONAL LINGUISTICS, GRENOBLE, FRANCE, AUGUST 23-25, 1967).

    Science.gov (United States)

    1967

    THE PAPERS IN THIS VOLUME--CATEGORIZED AS EITHER (1) AUTOMATIC ANALYSES OF NATURAL LANGUAGES, (2) STATISTIC AND SEMANTIC ANALYSES OF LINGUISTIC DATA, OR (3) ALGEBRAIC THEORIES OF LANGUAGES--ARE THE COLLECTIVE PRODUCT OF THE INTERNATIONAL CONFERENCE ON COMPUTATIONAL LINGUISTICS HELD AT GRENOBLE, FRANCE, AUGUST 23-25, 1967. TOPICS RANGE FROM…

  18. First commissioning results with the Grenoble test electron cyclotron resonance ion source at iThemba LABS

    Energy Technology Data Exchange (ETDEWEB)

    Thomae, R.; Conradie, J.; Delsink, H.; Du Plessis, H.; Fourie, D.; Klopp, M.; Kohler, I.; Lussi, C.; McAlister, R.; Ntshangase, S.; Sakildien, M. [iThemba LABS, P.O Box 722, Somerset West 7130 (South Africa); Hitz, D. [CEA/DRFMC, 17 Av. Des Martyrs, 38054, Grenoble Cedex 9 (France); Kuechler, D. [CERN, BE/ABP/HSL, 1211 Geneva 23 (Switzerland)

    2012-02-15

    iThemba Laboratory for Accelerator Based Science (iThemba LABS) is a multi-disciplinary accelerator facility. One of its main activities is the operation of a separated-sector cyclotron with a K-value of 200, which provides beams of various ion species. These beams are used for fundamental nuclear physics research in the intermediate energy region, radioisotope production, and medical physics applications. Due to the requirements of nuclear physics for new ion species and higher energies, the decision was made to install a copy of the so-called Grenoble test source (GTS) at iThemba LABS. In this paper, we will report on the experimental setup and the first results obtained with the GTS2 at iThemba LABS.

  19. First commissioning results with the Grenoble test electron cyclotron resonance ion source at iThemba LABS.

    Science.gov (United States)

    Thomae, R; Conradie, J; Delsink, H; Du Plessis, H; Fourie, D; Hitz, D; Klopp, M; Kohler, I; Kuechler, D; Lussi, C; McAlister, R; Ntshangase, S; Sakildien, M

    2012-02-01

    iThemba Laboratory for Accelerator Based Science (iThemba LABS) is a multi-disciplinary accelerator facility. One of its main activities is the operation of a separated-sector cyclotron with a K-value of 200, which provides beams of various ion species. These beams are used for fundamental nuclear physics research in the intermediate energy region, radioisotope production, and medical physics applications. Due to the requirements of nuclear physics for new ion species and higher energies, the decision was made to install a copy of the so-called Grenoble test source (GTS) at iThemba LABS. In this paper, we will report on the experimental setup and the first results obtained with the GTS2 at iThemba LABS.

  20. [The value of a child abuse observation clinic. Report of an experience in the area of Grenoble].

    Science.gov (United States)

    Bost, M; Nalpas, D; Menon, M

    1990-01-01

    In France the epidemiology of child abuse is badly known, because of the lack of connexion between different institutions. We present a child abuse observatory set up in Grenoble in May 1987. The social, educational, judicial and medical department's services are working together. In the first 20 months, 87 cases were recorded: 57 physical abuse, 26 sexual abuse and 5 cases of abuses due to negligence. Precise information was collected concerning the victims, their siblings, the family's risk factor and the offenders, the method by which the information was obtained and the prosecution undertaken. A 10 July 1989 law enforced each Department's governor to set up a service for collecting information about child abuse. Our observatory will serve as a model for this law application.

  1. ATTRACTIVITE TERRITORIALE: L’IMPACT DE LA DIFFERENCE CULTURELLE. COMPARAISON ENTRE LES TERRITOIRES DE IASI (ROUMANIE ET DE GRENOBLE (FRANCE

    Directory of Open Access Journals (Sweden)

    Alain SPALANZANI

    2015-04-01

    Full Text Available Cet article cherche à comprendre si la culture, plus particulièrement économique, a un impact sur la capacité d’attractivité des activités économiques d’un territoire. Les territoires comparés sont les métropoles ou régions urbaines de Iasi1 en Roumanie et de Grenoble en France. Ces territoires sont sensiblement de taille comparable : 840 000 habitants pour Iasi, 750 000 pour Grenoble. Après avoir recueilli les perceptions d’acteurs économiques, une hiérarchisation de plus de 71 critères considérés comme importants dans la localisation des activités économiques est établie pour chacune des deux régions. La comparaison de l’importance accordée aux critères montre à la fois une certaine convergence des perceptions mais aussi de réelles divergences, en particulier au niveau des critères financiers. La vision lowcost et de sous-traitance des yèchennï, liée à un positionnement de l’industrie roumaine sur les marchés de biens intermédiaires, n’est absolument pas partagée par les grenoblois qui semblent orientés vers des stratégies plus offensives, en direction des marchés finaux.

  2. 3rd CEAS Specialist Conference on Guidance, Navigation and Control

    CERN Document Server

    Drouin, Antoine; Roos, Clément

    2015-01-01

    The two first CEAS (Council of European Aerospace Societies) Specialist Conferences on Guidance, Navigation and Control (CEAS EuroGNC) were held in Munich, Germany in 2011 and in Delft, The Netherlands in 2013. ONERA The French Aerospace Lab, ISAE (Institut Supérieur de l’Aéronautique et de l’Espace) and ENAC (Ecole Nationale de l’Aviation Civile) accepted the challenge of jointly organizing the 3rd edition. The conference aims at promoting new advances in aerospace GNC theory and technologies for enhancing safety, survivability, efficiency, performance, autonomy and intelligence of aerospace systems. It represents a unique forum for communication and information exchange between specialists in the fields of GNC systems design and operation, including air traffic management. This book contains the forty best papers and gives an interesting snapshot of the latest advances over the following topics: l  Control theory, analysis, and design l  Novel navigation, estimation, and tracking methods l  Aircr...

  3. Scientific evaluation at the French Atomic Energy Commission (CEA). 2005-2006 annual report; L'evaluation scientifique au CEA. Rapport annuel 2005-2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This report aims at presenting the scientific evaluation activities carried out at the CEA during the years 2005-2006. The evaluation system is described in detail. It comprises two aspects: the evaluation of the scientific policy implemented by the scientific Council and by the visiting committee of the CEA, and the evaluation of the laboratories, performed by a pool of 36 scientific councils. The evaluation by external and independent parties is the key point of this system. This document makes a status of the evaluations performed in 2005 and 2006. It presents a synthesis of the conclusions of the evaluation authorities. The actions implemented by the CEA to take into consideration the recommendations are also reported with the improvements noticed. The two topics examined by the scientific Committee and by the visiting committee were dealing with the energy domain, which is a strategic issue for the CEA. The examination of the researches on future nuclear reactors and on new energy technologies have shown the major role played by the CEA in the recent advances in these domains. About 95% of the laboratories activity was examined during the 2002-2005 period. The richness of the remarks and recommendations made by the scientific councils should allow the CEA to improve the quality and relevance of its research works. The start-up of the 2006-2009 evaluation cycle has been the occasion to modify the evaluation of some research domains in order to take into account the evolution of programs. The evaluation system of the CEA is highly consistent with the AERES principles. Its implementation, adapted to each type of activity (fundamental research, applied research, technological developments) allows the CEA to follow up a permanent improvement approach. (J.S.)

  4. Los frutos de las cactáceas y su potencial como materia prima

    OpenAIRE

    Patricia Esquivel

    2004-01-01

    Los frutos de las Cactáceas y su potencial como materia prima. Se presenta información sobre las características generales, así como usos actuales y potenciales de los miembros más importantes, desde un punto de vista comercial, de la familia de las cactáceas.

  5. Difficulties and dangers of CEA-targeted immunotherapy against colorectal cancer

    NARCIS (Netherlands)

    Bos, Rinke

    2006-01-01

    The studies described in this thesis focus on the feasibility of using carcinoembryonic antigen (CEA) as a target for immunotherapy of colorectal cancer and on the balance between anti-tumor immunity and autoimmune pathology. The potential of CEA as a target antigen for immunotherapy of cancer is co

  6. Atualidades e perspectivas das Anonáceas no mundo

    Directory of Open Access Journals (Sweden)

    Abel Rebouças São José

    2014-01-01

    Full Text Available Várias espécies da família Annonaceae produzem frutos comestíveis cultivados em pomares comerciais ou coletados de forma extrativista, em diversas partes do mundo. O gênero Annona possui elevado número de espécies nativas, no entanto poucas produzem frutos comestíveis. Algumas são cultivadas comercialmente, outras são obtidas de forma extrativista. As principais anonáceas cultivadas no mundo são: Annona muricata, Annona squamosa e Annona cherimola, com destaque também para a atemoia (híbrido entre A. squamosa x A. cherimola. Economicamente, são importantes para muitos países da África, Ásia e também da América Central, do Norte e do Sul. Os principais países produtores são: Austrália, Chile, Espanha, Estados Unidos, Nova Zelândia e Israel para cherimólia; México, Brasil, Venezuela e Costa Rica para graviola; e Índia, Brasil, Tailândia, Filipinas e Cuba para pinha. A produtividade de frutos das anonáceas nos diversos países produtores é relativamente baixa, em função do uso inadequado de técnicas de manejo (irrigação, fertilização, podas, polinização, controle de insetos e enfermidades, etc.. No Brasil, os cultivos comerciais mais relevantes com anonáceas são: pinha (A. squamosa L., graviola (A. muricata L. e atemoia. O objetivo deste trabalho é apresentar a situação atual e as perspectivas para as anonáceas no Brasil e no mundo. O cultivo é caracteristicamente de pequenos agricultores, usando especialmente a mão de obra familiar. De um modo geral, esses cultivos apresentam relevância socioeconômica nos países que possuem produção comercial pela geração de emprego e renda, e vêm, recentemente, ganhando importância no mercado mundial, dada sua condição de fruta exótica e pela sua qualidade, dentre as quais o valor nutracêutico (vitaminas, antioxidantes e outras propriedades funcionais. A expansão do consumo e sua maior relevância no mercado mundial dependem de ações relativas

  7. Saclay CEA Centre. Environmental assessment 2009; Bilan environnemental 2009

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-06-15

    This report presents the environmental control organization (sampling places and frequencies) about the Saclay CEA centre, and indicates the authorized levels for liquid and gaseous effluent releases by its installations. It comments the obtained results concerning air quality, water quality (surface and underground waters), bio-indicators (sampling and measurements performed in grasses, fruits, vegetables, milk, and so on, with notably the presence of Tritium of K40), and the assessment of the radiological impact due to annual radioactive releases. The report discusses the evolution of Tritium releases since 1968, and gives an assessment of these releases before 1968 (i.e. before it has been systematically controlled). It comments the new regulation regarding releases and gives a comparison with the releases limits defined in 1978. A brief presentation of the Saclay center environmental policy is given

  8. Planta de lavado para arena silícea

    OpenAIRE

    Rojo García, Cristina

    2008-01-01

    El proyecto fin de carrera trata sobre la instalación de una planta móvil de lavado para arena silícea. Este recurso está presente en el Monte Público nº 90 denominado “RAJICA DE EN MEDIO” en el Término Municipal de Jumilla (Murcia), donde se ubica la cantera “Los Mochuelos” de la que es concesionaria y explotadora la empresa JUMILLANA DE SÍLICE, S.L, con C.I.F. nº B-25.646.720, con domicilio social en C/ Canalejas nº 83, Bajo, de Jumilla (Murcia). Por ello, el presente proyecto tien...

  9. METABOLISMO ÁCIDO DE LAS CRASULÁCEAS

    Directory of Open Access Journals (Sweden)

    THOMAS DAVID GEYDAN

    2005-01-01

    Full Text Available Se presenta una revisión del metabolismo ácido de las Crasuláceas, caracterizado por la ocurrencia, actividad y plasticidad del mecanismo desde un punto de vista fisio- lógico, bioquímico y molecular, enmarcado por la presencia de las denominadas cuatro fases de dicho metabolismo y su repercusión y expresión por diversas restric- ciones hídricas a nivel ecológico. Se presentan las principales enzimas y metabolitos básicos para el funcionamiento del metabolismo CAM, así como su modo de acción y control celular. Finalmente, se muestra que la plasticidad fenotípica en patrones de expresión CAM se encuentra mediada por condiciones ambientales y por señaliza- ciones moleculares.

  10. Fluorescence resonance energy transfer biosensor between upconverting nanoparticles and palladium nanoparticles for ultrasensitive CEA detection.

    Science.gov (United States)

    Li, Hui; Shi, Liang; Sun, De-En; Li, Peiwu; Liu, Zhihong

    2016-12-15

    An ultrasensitive biosensor for carcinoembryonic antigen (CEA) was constructed based on fluorescence resonance energy transfer (FRET) between upconverting nanoparticles (UCPs) and palladium nanoparticles (PdNPs). PdNPs was synthesized by the addition of a solution of Na2PdCl4 into a mixture of N2H4·H2O as the reducing agent and 11-mercaptoundecanoic acid (MUDA) as the stabilizer. The CEA aptamer (5'-NH2-ATACCAGCTTATTCAATT-3') was conjugated to hexanedioic acid (HDA) modified UCPs (HDA-UCPs) through an EDC-NHS coupling protocol. The coordination interaction between nitrogen functional groups of the CEA aptamer and PdNPs brought UCPs and PdNPs in close proximity, which resulted in the fluorescence quenching of UCPs to an extent of 85%. And the non-specific fluorescence quenching caused by PdNPs towards HDA-UCPs was negligible. After the introduction of CEA into the UCPs-CEA aptamer-PdNPs fluorescence quenching system, the CEA aptamer preferentially combined with CEA accompanied by the conformational change which weakened the coordination interaction between the CEA aptamer and PdNPs. So fluorescence recovery of UCPs was observed and a linear relationship between the fluorescence recovery of UCPs and the concentration of CEA was obtained in the range from 2pg/mL to 100pg/mL in the aqueous buffer with the detection limit of 0.8pg/mL. The ultrasensitive detection of CEA was also realized in diluted human serum with a linear range from 4pg/mL to 100pg/mL and a detection limit of 1.7pg/mL. This biosensor makes the most of the high quenching ability of PdNPs towards UCPs with negligible non-specific fluorescence quenching and has broad application prospects in biochemistry.

  11. [Role of E. coli enterotoxins in the etiology of infantile diarrhea. Comparison of an African country Yaoundé (Cameroon) and France (Grenoble)].

    Science.gov (United States)

    Foucaud-Gamen, J; Le Noc, P; Renaudet, J; Guimet, J

    1988-01-01

    The detection of heat-labile enterotoxin by two tests (culture on Y1 cells and GM1-ELISA) has been carried out on strains of E. coli isolated in stools of children with diarrheal disease (220 strains isolated in the Pasteur Institute in Yaoundé, Cameroon, and 133 stool specimens selected in Grenoble). This work was undertaken to determine the frequency of enterotoxigenic E. coli in two different populations. In Yaoundé the isolation rate (6%) is not very high in comparison with other developing countries. It should be observed that some strains belong to enteropathogenic serogroups. In Grenoble results confirm the very low frequency of enterotoxigenic E. coli in industrialized countries.

  12. Members of the International Cryogenic Engineering Committee visit the CMS experiment at Point 5 during the Nineteenth International Cryogenic Engineering Conference (ICEC 19) in Grenoble, France (22-26 July 2002).

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Members of the International Cryogenic Engineering Committee visit the CMS experiment at Point 5 during the Nineteenth International Cryogenic Engineering Conference (ICEC 19) in Grenoble, France (22-26 July 2002).

  13. Protocol for the treatment of malignant inoperable bowel obstruction: a prospective study of 80 cases at Grenoble University Hospital Center.

    Science.gov (United States)

    Laval, Guillemette; Arvieux, Catherine; Stefani, Laetitia; Villard, Marie-Laure; Mestrallet, Jean-Phillippe; Cardin, Nicolas

    2006-06-01

    A prospective protocol for treatment of malignant inoperable bowel obstruction was implemented at Grenoble University Hospital Center for 4 years. All 80 episodes of obstruction resulted from peritoneal carcinomatosis and none could expect another treatment cure. The protocol comprised three successive stages. Stage I included treatment for 5 days with a corticosteroid, antiemetic, anticholinergic, and analgesic. Stage II provided a somatostatin analogue if vomiting persisted. After 3 days, Stage III provided a venting gastrostomy. Obstruction relief with symptom control was obtained by medical treatment in 29 cases and symptom control occurred alone in an additional 32 cases. Ten patients were relieved by venting gastrostomy. Symptom control without permanent nasogastric tube (NGT) placement occurred in 72 episodes (90%). Eight patients with refractory vomiting were obliged to continue the NGT until death. Fifty-eight obstruction episodes (73%) were controlled in 10 days or less. Median time before gastrostomy was 17 days. Median survival was 31 days. This series suggests that a staged protocol for the treatment of inoperable malignant bowel obstruction is highly effective in relieving symptoms. A subgroup experiences relief of obstruction using this approach.

  14. Impacts of land-use and land-cover changes on rockfall propagation: Insights from the Grenoble conurbation.

    Science.gov (United States)

    Lopez-Saez, Jérôme; Corona, Christophe; Eckert, Nicolas; Stoffel, Markus; Bourrier, Franck; Berger, Frédéric

    2016-03-15

    Several studies have debated the incidence of global warming on the probability of rock instability, whereas the impacts of land use and land cover (LULC) changes on rockfall propagation and associated hazards have received comparably little interest. In this study we evaluate the impacts of LULC changes on rockfall hazards on the slopes above the village of Crolles (Chartreuse massif, Grenoble conurbation, French Alps) through a three-level approach: (i) diachronic landscape analysis for four different periods of the past (i.e. 1850, 1956, 1975, and 2013), (ii) computation of 3D rockfall simulations taking explicitly account of reconstructed LULC changes, and (iii) resulting changes in rockfall hazards over time. We reveal that the disappearance of viticultural landscapes (relating to the decline of cropping areas during the interwar period) and intense afforestation of the steepest upper portion of the slope resulted in a significant increase of rockfall return period associated to a gradual decrease of mean kinetic energy at the level of the urban front of Crolles. According to the Eurobloc methodology, the degree of hazard decreased significantly despite the continuous and rapid urban sprawl on the slopes. These results underline that forests can indeed have significant protection function but also call for a more systematic inclusion of LULC changes in hazard assessments in the future.

  15. Fusion technology. Annual report of the. Association Cea/EURATOM; Technologie de fusion.Rapport annuel de l`association CEA/Euratom

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le Vagueres, F.

    1996-12-31

    In 1996, the French EURATOM-CEA Association made significant contributions to the European technology programme. This work is compiled in this report as follows: the ITER CEA activities and related developments are described in the first section; blankets and material developments for DEMO, long term safety studies are summarised in the second part; the Underlying Technology activities are compiled in the third part of this report. In each section, the tasks are sorted out to respect the European presentation. For an easy reading, appendix 4 gives the list of tasks in alphabetical order with a page reference list. The CEA is in charge of the French Technology programme. Three specific organizational directions of the CEA, located on four sites (see appendix 5) are involves in this programme: Advanced Technologies Direction (DTA), for Material task; Nuclear Reactors Direction (DRN), for Blanket design, Neutronic problems, Safety tasks; Physical Sciences Direction (DSM) uses the competence of the Tore Supra team in the Magnet design and plasma Facing Component field. The CEA programme is completed by collaborations with Technicatome, COMEX-Nucleaire and Ecole Polytechnique. The breakdown of the programme by Directions is presented in figure 1. The allocation of tasks is given in appendix 2 and in appendix 3, the related publications. (author).

  16. Anti-CEA loaded maghemite nanoparticles as a theragnostic device for colorectal cancer

    Directory of Open Access Journals (Sweden)

    Campos da Paz M

    2012-10-01

    Full Text Available Mariana Campos da Paz,1 Maria de Fátima M Almeida Santos,1 Camila MB Santos,2 Sebastião W da Silva,2 Lincoln Bernardo de Souza,3 Emília CD Lima,3 Renata C Silva,1 Carolina M Lucci,1 Paulo César Morais,2 Ricardo B Azevedo,1 Zulmira GM Lacava11Instituto de Ciências Biológicas; 2Instituto de Física, Universidade de Brasília, Brasília, DF, Brazil; 3Instituto de Química, Universidade Federal de Goiás, Goiânia, GO, BrazilAbstract: Nanosized maghemite particles were synthesized, precoated (with dimercaptosuccinic acid and surface-functionalized with anticarcinoembryonic antigen (anti-CEA and successfully used to target cell lines expressing the CEA, characteristic of colorectal cancer (CRC cells. The as-developed nanosized material device, consisting of surface decorated maghemite nanoparticles suspended as a biocompatible magnetic fluid (MF sample, labeled MF-anti-CEA, was characterized and tested against two cell lines: a high-CEA expressing cell line (LS174T and a low-CEA expressing cell line (HCT116. Whereas X-ray diffraction was used to assess the average core size of the as-synthesized maghemite particles (average 8.3 nm in diameter, dynamic light scattering and electrophoretic mobility measurements were used to obtain the average hydrodynamic diameter (550 nm and the zeta-potential (−38 mV of the as-prepared and maghemite-based nanosized device, respectively. Additionally, surface-enhanced Raman spectroscopy (SERS was used to track the surface decoration of the nanosized maghemite particles from the very first precoating up to the attachment of the anti-CEA moiety. The Raman peak at 1655 cm−1, absent in the free anti-CEA spectrum, is the signature of the anti-CEA binding onto the precoated magnetic nanoparticles. Whereas MTT assay was used to confirm the low cell toxicity of the MF-anti-CEA device, ELISA and Prussian blue iron staining tests performed with both cell lines (LS174T and HCT116 confirm that the as-prepared MF-anti-CEA

  17. Numerical Platon: A unified linear equation solver interface by CEA for solving open foe scientific applications

    Energy Technology Data Exchange (ETDEWEB)

    Secher, Bernard [French Atomic Energy Commission (CEA), Nuclear Energy Division (DEN) (France); CEA Saclay DM2S/SFME/LGLS, Bat. 454, F-91191 Gif-sur-Yvette Cedex (France)], E-mail: bsecher@cea.fr; Belliard, Michel [French Atomic Energy Commission (CEA), Nuclear Energy Division (DEN) (France); CEA Cadarache DER/SSTH/LMDL, Bat. 238, F-13108 Saint-Paul-lez-Durance Cedex (France); Calvin, Christophe [French Atomic Energy Commission (CEA), Nuclear Energy Division (DEN) (France); CEA Saclay DM2S/SERMA/LLPR, Bat. 470, F-91191 Gif-sur-Yvette Cedex (France)

    2009-01-15

    This paper describes a tool called 'Numerical Platon' developed by the French Atomic Energy Commission (CEA). It provides a freely available (GNU LGPL license) interface for coupling scientific computing applications to various freeware linear solver libraries (essentially PETSc, SuperLU and HyPre), together with some proprietary CEA solvers, for high-performance computers that may be used in industrial software written in various programming languages. This tool was developed as part of considerable efforts by the CEA Nuclear Energy Division in the past years to promote massively parallel software and on-shelf parallel tools to help develop new generation simulation codes. After the presentation of the package architecture and the available algorithms, we show examples of how Numerical Platon is used in sequential and parallel CEA codes. Comparing with in-house solvers, the gain in terms of increases in computation capacities or in terms of parallel performances is notable, without considerable extra development cost.

  18. Meeting of Directors and Heads of Department from CEA-Saclay, France

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Y. Lemoigne (left) in discussion with M. Spiro during the visit to CERN of Directors and Heads of Department from the Saclay centre of the French atomic energy commision (CEA) in December. P. Jarry looks on.

  19. Comparison of Ablation Predictions for Carbonaceous Materials Using CEA and JANAF-Based Species Thermodynamics

    Science.gov (United States)

    Milos, Frank S.

    2011-01-01

    In most previous work at NASA Ames Research Center, ablation predictions for carbonaceous materials were obtained using a species thermodynamics database developed by Aerotherm Corporation. This database is derived mostly from the JANAF thermochemical tables. However, the CEA thermodynamics database, also used by NASA, is considered more up to date. In this work, the FIAT code was modified to use CEA-based curve fits for species thermodynamics, then analyses using both the JANAF and CEA thermodynamics were performed for carbon and carbon phenolic materials over a range of test conditions. The ablation predictions are comparable at lower heat fluxes where the dominant mechanism is carbon oxidation. However, the predictions begin to diverge in the sublimation regime, with the CEA model predicting lower recession. The disagreement is more significant for carbon phenolic than for carbon, and this difference is attributed to hydrocarbon species that may contribute to the ablation rate.

  20. Nuclear. In China, the CEA asserts itself as a team leader; Nucleaire: en Chine, le CEA s'impose en meneur de jeu

    Energy Technology Data Exchange (ETDEWEB)

    Dupin, L.

    2011-03-15

    As the French government gave the CEA the responsibility of negotiating the nuclear French-Chinese nuclear strategic partnership, this article outlines the personality of the CEA's chairman, Bernard Bigot, but also the tensions which exist between the two main actors of the French nuclear industry, EDF and Areva, notably about their respective projects of development of a new reactor with China as far as EDF is concerned, and with Japan as far as Areva is concerned. In fact, China is asking France, not to build new reactors but to improve the performance and the safety in the existing ones

  1. [CEA and early detection of relapse in breast cancer subtypes: Comparison with CA 15-3].

    Science.gov (United States)

    Riedinger, Jean-Marc; Goussot, Vincent; Desmoulins, Isabelle; Lorgis, Véronique; Coutant, Charles; Beltjens, Françoise; Lizard, Sarab; Fumoleau, Pierre

    2016-05-01

    This retrospective study evaluates the interest of CEA measurement for early detection of breast cancer recurrences. Among 804 patients with invasive breast cancer, we selected 97 patients without recurrence (WR) for 5 years or more, 32 with a local recurrence (LR) and 131 with at least one distant metastasis (DM). Elevated CEA and CA 15-3 levels (>3.1 μg/L and >26 kU/L respectively) were found in 6 % and 22 % of patients with RL respectively and in 49 % and 69 % of patients with DM. Both CEA and CA 15-3 retained a significant value in predicting DM by univariate and multivariate analysis. Higher sensitivity of CEA and CA 15-3 were found in tumors with positive hormonal receptor status. CEA and CA 15-3 levels at DM were raised respectively in 23 and 65 % of the triple negative group, 58 and 75 % of the luminal, 56 and 78 % of the luminal-HER2 and 50 and 30 % of HER2-enriched group (P=0.0094 and 0.0252 respectively). The combination of CEA and CA 15-3 increased CA 15-3 sensitivity in especially luminal and HER2-enriched groups. In conclusion, elevated CA 15-3 and CEA levels at initial diagnosis of recurrence were found to be associated with hormonal receptor status and breast cancer subtypes. The combination of CEA and CA 15-3 appeared useful especially luminal and HER2-enriched groups.

  2. Program improvements in the CEA service continuity: report and impact of the ice storm on CEA data

    Energy Technology Data Exchange (ETDEWEB)

    Billinton, R. [Saskatchewan Univ., Saskatoon, SK (Canada)

    1999-09-01

    The Canadian Electrical Association has been collecting statistical data on various aspects of electric power generation, transmission and distribution since 1979, when the Equipment Reliability Information System (ERIS) database has been implemented. Currently, the CEA publishes annual reports and statistics on generation and transmission component outages. Data gathering and reporting is monitored and guided by the Consultative Committee on Outage Statistics (CCOS). The Electric Power System Reliability Assessment (EPSRA) protocols represent the second stage of reliability data development. This system is designed to collect and report on data relating to the overall electricity supply system and the overall performance of the bulk electricity system. (ERIS reporting is concerned with equipment outages). This paper describes the Service Continuity Reporting System segment of the EPSRA protocols. Details of performance in service continuity for 1998 are provided with and without the 1998 ice storms effects. The complete data and indices on each participating utility, together with the overall Canada and total participating utility data, provides a convenient base for general utility comparisons. Comparisons of the various indices of reliability with like statistics from electric utility companies of Australia, New Zealand and the United States are also provided. 2 tabs., 1 fig.

  3. [Free-living amoebae in the Grenoble area swimming pool water. Influence of th "winter-summer" use and of the sterilising procedure (author's transl)].

    Science.gov (United States)

    Grillot, R; Ambroise-Thomas, P

    1980-01-01

    An epidemiological study concerning the search for and identification of free-living amoebae has been carried out on swimming pool water in the Grenoble area. Eleven establishments were surveyed over a period of one year, by taking samples of water every month. The results obtained show that the positive nature of the samples and the nature of the isolated species are influenced by the two factors being studied: The rhythm of the "Summer-Winter" use of swimming pools and the nature of the sterilising procedure, chlorine, bromine and ozone. The current sterilising conditions of the swimming pool water are discussed.

  4. Contribution of Dense Array Analysis to the Identification and Quantification of Basin-Edge-Induced Waves, Part II: Application to Grenoble Basin (French Alps)

    OpenAIRE

    Cornou, C.; BARD, PY; Dietrich, M.

    2003-01-01

    Settled on a deep sediment-filled valley, the city of Grenoble (French Alps) faces important site effects: large amplification and significant duration increase of ground motion, even for moderate-size events. In order to study multidimensional site effects, a very dense array composed of 29 three-component seismometers over a 1-km aperture was operated during spring 1999 in the center of the city. A total of 18 events (6 local, 4 regional, and 8 teleseismic) with an acceptable signal-to-nois...

  5. Visible and near-infrared reflectance spectroscopy of planetary analog materials. Experimental facility at Laboratoire de Planetologie de Grenoble.

    Science.gov (United States)

    Pommerol, A.; Brissaud, O.; Schmitt, B.; Quirico, E.; Doute, S.

    2007-08-01

    We have developed an original experimental facility designed to measure the bidirectional reflectance spectra of planetary analog materials. These measurements are helpful to interpret the observations of the spectrometers on board space probes in orbit around various Solar System bodies. The central part of the facility is the LPG spectrogonio- radiometer (Brissaud et al., 2004). This instrument provides measurements of samples BRDF (Bidirectional Reflectance Distribution Function) with high photometric and spectrometric accuracy in the spectral range of visible and near-infrared (0.3 - 4.8 microns). Measurements can be made at any value of incidence and emergence angle up to 80°. Azimuth angle is allowed to vary between 0 and 180°. The instrument was recently installed in a cold room allowing ambient temperatures as low as -20°C. This makes possible the measurements on different kinds of water ice samples (slab ice, frost, snow...) and mixtures of minerals and water ice with unprecedented accuracy. We also have designed and built a simulation chamber to measure spectra of samples (water ice and/or minerals) under an atmosphere with perfectly controlled temperature, pressure and composition. The main objective of this last improvement is the study of water exchange between planetary regolith analogs and atmosphere (adsorption/ desorption, condensation/sublimation). Experimental results will mainly apply to Martian water cycle and hydrated mineralogy. This simulation chamber also provides an efficient way to obtain bidirectional reflectance spectra of dry materials (removal of adsorbed water) with implications for planetary bodies without atmospheric or surface water (Titan, asteroids...). The reflectance spectroscopy facility is part of a large panel of instruments and techniques available at Laboratoire de Planetologie de Grenoble that provide complementary measurements on the same samples: infrared transmission spectroscopy of thin ice films, thick liquid and

  6. Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients

    Science.gov (United States)

    Tsouma, Aikaterini; Aggeli, Chrysanthi; Lembessis, Panagiotis; Zografos, George N; Korkolis, Dimitris P; Pectasides, Dimitrios; Skondra, Maria; Pissimissis, Nikolaos; Tzonou, Anastasia; Koutsilieris, Michael

    2010-01-01

    AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting circulating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors’ clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P < 0.001) and preoperative serum levels of CEA (P = 0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented significant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RT-PCR assay can provide useful information concerning disease stage and overall survival of CRC patients. PMID:21157973

  7. Utility of serum CA19-9 in diagnosis of cholangiocarcinoma:In comparison with CEA

    Institute of Scientific and Technical Information of China (English)

    Xing-Lei Qin; Zuo-Ren Wang; Jing-Sen Shi; Min Lu; Lin Wang; Quan-Ru He

    2004-01-01

    AIM: The diagnosis of cholangiocarcinoma is often difficult,making management approaches problematic. A reliable serum marker for cholangiocarcinoma would be a useful diagnostic test. The aims of our study were to evaluate the usefulness of a serum CA19-9 determination in the diagnosis of cholangiocareinoma.METHODS: We prospectively measured serum CA19-9 and CEA concentrations in patients with cholangiocarcinoma (n=35), benign biliary diseases (n=92), and healthy individuals n=15). Serum CA19-9 and CEA concentrations were measured by an immunoradiometric assay without knowledge of the clinical diagnosis.were 77.14% and 68.57%, respectively. When compared with the benign biliary diseases group, the true negative rates of serum CA19-9 and CEA were 84.78% and 81.52%,respectively, The false positive rates of serum CA19-9 and CEA were 15.22% and 18.48%, whereas the accuracy of serum CA19-9 and CEA were 82.68% and 77.95%,respectively. Serum CA19-9 and CEA concentrations were significantly elevated (P<0.001 and P<0.05) in patients with patients undergoing curative resection of cholangiocareinoma,the mean serum CA19-9 concentration was decreased from however, no correlation was found between serum CEA and CA19-9 concentrations (r=0.036).CONCLUSION: These data suggest that the serum CA19-9 determination is a usefol addition to the available tests for the differential diagnosis of cholangiocareinoma. Serum CA19-9 is an effective tumor marker in diagnosing cholangiocareinoma,deciding whether the tumor has been radically resected and monitoring effect of treatment.

  8. Fitoplancton del Parque Nacional Las Tablas de Daimiel. II. Las cianofíceas, los dinoflagelados, las criptofíceas, las crisofíceas y las xantofíceas

    Directory of Open Access Journals (Sweden)

    Rojo, Carmen

    1999-12-01

    Full Text Available Las Tablas de Daimiel National Park is a semiarid wetland that exhibits a high biodiversity but is suffering an inexorable eutrophication process. The study of the phytoplankton in this wetland is interesting because of its hydrological fluctuations (drought period until 1996 and its trophic condition. This papers shows the taxonomy, dynamic, and ecology of microalgae in five áreas of the Park from 1996 to 1998, which allow comparisons to be made between the present state and the 1992-1993 period. Twelve taxa of Cyanophyta, 4 of Dynophyceae, 8 of Cryptophyceae, 5 of Chrysophyceae and one of Xanthophyceae were found. Almost all species have been already cited in Spain and are typical for eutrophic environments. Cyanophyceae and Cryptophyceae were the most important groups (Planktothrix agardhii, Anabaenopsis elenkinii, Cryptomonas erosa as the most common algae. Moreover, oscillatorial Cyanophyceae (in 1992 have been replaced by N-fixing nostocal ones, related to the high level of pollution found in recent years.El Parque Nacional Las Tablas de Daimiel es un humedal semiárido, importante reserva de biodiversidad que, sin embargo, está sufriendo un inexorable proceso de eutrofización. Su estado trófico, así como los cambios hidrológicos (sequía hasta 1996, hacen especialmente interesante el estudio de su microflora. Por ello, se ha llevado a cabo este trabajo sobre las poblaciones fitoplanctónicas en cinco puntos del Parque desde 1996 a 1998, que permite además la comparación con su estado en 1992-1993. Se encontraron 12 táxones de Cyanophyta, 4 de Dynophyceae, 8 de Cryptophyceae, 5 de Chrysophyceae y uno de Xanthophyceae. Casi todas las especies están citadas en España y son propias de ambientes eutróficos. Los grupos mejor representados fueron las cianobacterias y criptofíceas (Planktothrix agardhii, Anabaenopsis elenkinii y Cryptomonas erosa fueron las especies más conspicuas. Además, se observa un cambio de cianobacterias

  9. Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines

    Science.gov (United States)

    Klein, Christian; Waldhauer, Inja; Nicolini, Valeria G.; Freimoser-Grundschober, Anne; Nayak, Tapan; Vugts, Danielle J.; Dunn, Claire; Bolijn, Marije; Benz, Jörg; Stihle, Martine; Lang, Sabine; Roemmele, Michaele; Hofer, Thomas; van Puijenbroek, Erwin; Moser, Samuel; Ast, Oliver; Brünker, Peter; Gorr, Ingo H.; Neumann, Sebastian; Hinton, Heather; Crameri, Flavio; Gerdes, Christian; Bacac, Marina; van Dongen, Guus; Moessner, Ekkehard; Umaña, Pablo

    2017-01-01

    ABSTRACT We developed cergutuzumab amunaleukin (CEA-IL2v, RG7813), a novel monomeric CEA-targeted immunocytokine, that comprises a single IL-2 variant (IL2v) moiety with abolished CD25 binding, fused to the C-terminus of a high affinity, bivalent carcinoembryonic antigen (CEA)-specific antibody devoid of Fc-mediated effector functions. Its molecular design aims to (i) avoid preferential activation of regulatory T-cells vs. immune effector cells by removing CD25 binding; (ii) increase the therapeutic index of IL-2 therapy by (a) preferential retention at the tumor by having a lower dissociation rate from CEA-expressing cancer cells vs. IL-2R-expressing cells, (b) avoiding any FcγR-binding and Fc effector functions and (c) reduced binding to endothelial cells expressing CD25; and (iii) improve the pharmacokinetics, and thus convenience of administration, of IL-2. The crystal structure of the IL2v-IL-2Rβγ complex was determined and CEA-IL2v activity was assessed using human immune effector cells. Tumor targeting was investigated in tumor-bearing mice using 89Zr-labeled CEA-IL2v. Efficacy studies were performed in (a) syngeneic mouse models as monotherapy and combined with anti-PD-L1, and in (b) xenograft mouse models in combination with ADCC-mediating antibodies. CEA-IL2v binds to CEA with pM avidity but not to CD25, and consequently did not preferentially activate Tregs. In vivo, CEA-IL2v demonstrated superior pharmacokinetics and tumor targeting compared with a wild-type IL-2-based CEA immunocytokine (CEA-IL2wt). CEA-IL2v strongly expanded NK and CD8+ T cells, skewing the CD8+:CD4+ ratio toward CD8+ T cells both in the periphery and in the tumor, and mediated single agent efficacy in syngeneic MC38-CEA and PancO2-CEA models. Combination with trastuzumab, cetuximab and imgatuzumab, all of human IgG1 isotype, resulted in superior efficacy compared with the monotherapies alone. Combined with anti-PD-L1, CEA-IL2v mediated superior efficacy over the respective

  10. How to Add Value to your Business with CEA: A Practical Approach

    Directory of Open Access Journals (Sweden)

    Daniel Cardenas

    2010-04-01

    Full Text Available Companies are always trying to differentiate themselves from the rest of the pack by applying different strategies such as improving customer service, increasing the efficiency of their operations, or reducing their costs. Most of the time, however, these goals are competing against each other for scarce resources, and managers often need to decide to concentrate on one. A small company can effectively and simultaneously accomplish these goals for a fraction of the cost by implementing communications-enabled business processes or solutions, which are a set of technology components that add real-time networking functionality to applications. One particular implementation of this framework is the one provided by Coral CEA. Coral CEA is a business ecosystem anchored around CEA functionalities that are offered as building blocks, out-of-the-box components that link the capabilities and intelligence of networks platforms with the power of current applications to provide a new set of features and functionalities. In this article, we show how a small company called Rezact, located in the ski resort town of Mont-Tremblant, Quebec, successfully implemented CEA capabilities within its own operations using Coral CEA services.

  11. Label-free fluorimetric detection of CEA using carbon dots derived from tomato juice.

    Science.gov (United States)

    Miao, Hong; Wang, Lan; Zhuo, Yan; Zhou, Zinan; Yang, Xiaoming

    2016-12-15

    A facile-green strategy to synthesize carbon dots (CDs) with a quantum yield (QY) of nearly 13.9% has been built up, while tomato juice served as the carbon source. Interestingly, not only the precursor of CDs and the whole synthesis procedure were environmental-friendly, but this type of CDs also exhibited multiple advantages including high fluorescent QY, excellent photostability, non-toxicity and satisfactory stability. Significantly, a label-free sensitive assay for detecting carcinoembryonic antigen (CEA) in a continuous and recyclable way has been proposed on the basis of adsorption and desorption of aptamers by the surface of CDs through a competitive mechanism. To be specific, the richness of carboxyl groups of the CDs enabled strong adsorption of ssDNA to the surface of CDs through π-π stacking interactions, resulting in the effective fluorescence quenching by forming CDs-aptamer complexes. The stronger binding affinity between CEA and CEA-aptamer than the π-π stacking interactions has been taken advantage to achieve immediate recovery of the fluorescence of CDs once CEA was introduced. Thereby, quantitative evaluation of CEA concentration in a broad range from 1ngmL(-1) to 0.5ngmL(-1) with the detection limit of 0.3ngmL(-1) was realized in this way. This strategy can be applied in a recyclable way, broadening the sensing application of CDs with biocompatibility. Besides, the CDs were used for cell imaging, potentiating them towards diverse purposes.

  12. Axillary versus peripheral blood levels of sialic acid, ferritin, and CEA in patients with breast cancer.

    Science.gov (United States)

    Monti, M; Catania, S; Locatelli, E; Gandini, R; Reggiani, A; Cunietti, E

    1990-12-01

    Serum levels of total sialic acid, carcinoembryonic antigen (CEA), ferritin, lactate dehydrogenase, and creatine phosphokinase were measured both in tumor drainage blood (axillary vein) and in peripheral blood obtained from 121 breast cancer patients during surgery. No significant differences between mean values in peripheral and tumor draining blood, between cancer patients and healthy controls, or between patients with or without axillary lymph node metastases were found for any of the markers. Both ferritin and CEA levels were higher in axillary and peripheral blood from patients with central breast cancer versus other sites but the difference was significant only for CEA (p less than 0.05). CEA levels were significantly higher (p less than 0.01) in patients with greater than 2 cm diameter carcinomas versus T1 stage patients in axillary but not in peripheral blood. When the cephalic vein was clamped before the axillary sample was taken, ferritin showed a significant increase (p less than 0.05). We conclude that measurement of sialic acid, CEA, and ferritin in axillary venous blood in breast cancer patients is not of clinical benefit, although further data are needed to clarify whether other advantages can be derived.

  13. Assessment of CA 15.3, CEA and TPA concentrations during monitoring of breast cancer

    DEFF Research Database (Denmark)

    Sölétormos, G; Petersen, P H; Dombernowsky, P

    2000-01-01

    The variability of the tumor markers cancer antigen (CA) 15.3, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) during steady state concentrations and the rate of increase during progression is described. One hundred and ninety-two patients were monitored during first-line chem......The variability of the tumor markers cancer antigen (CA) 15.3, carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA) during steady state concentrations and the rate of increase during progression is described. One hundred and ninety-two patients were monitored during first......-line chemotherapy for metastatic breast cancer and during follow-up. Blood specimens were sampled approximately every four weeks. Steady state concentrations were registered for 77 (CA 15.3), 96 (CEA), and 127 (TPA) patients with below cutoff level values and for 28 (CA 15.3), 25 (CEA), and 11 (TPA) patients...... with above cutoff level values. Clinical and marker progression was registered for 75 (CA 15.3), 62 (CEA), and 57 (TPA) patients. The coefficients of total variation of steady state concentrations (comprising the intra- and interassay analytical imprecision and the within subject biological variation) were...

  14. Quantitative analysis of anti-CEA antibody accumulation in human colorectal carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Bares, R. (Technische Hochschule Aachen (Germany). Dept. of Nuclear Medicine); Fass, J. (Technische Hochschule Aachen (Germany). Dept. of Surgery); Hauptmann, S. (Technische Hochschule Aachen (Germany). Dept. of Pathology); Braun, J. (Technische Hochschule Aachen (Germany). Dept. of Surgery); Grehl, O. (Technische Hochschule Aachen (Germany). Dept. of Nuclear Medicine); Reinartz, R. (Technische Hochschule Aachen (Germany). Dept. of Surgery); Buell, U. (Technische Hochschule Aachen (Germany). Dept. of Nuclear Medicine); Schumpelick, V. (Technische Hochschule Aachen (Germany). Dept. of Surgery); Mittermayer, C. (Technische Hochschule Aachen (Germany). Dept. of Pathology)

    1993-04-01

    In order to obtain quantitative data on intratumoral anitbody accumulation we analyzed resected colorectal adenocarcinomas of 25 patients who had undergone immunoscintigraphy 4-14 days earlier. All had been injected with 0.5-1.0 mg intact anti-CEA antibody (BW 431/26) labelled with 70-80 MBq [sup 131]I. Correlation of tissue radioactivity concentrations with tumor characteristics revealed significantly higher values in necrotic compared to viable as well as in CEA-positive compared to CEA-negative viable tumor tissue indicating action of both specific and unspecific uptake mechanisms. In contrast, diagnostic results of immunoscintigraphy were influenced by tumor size only. 11 of 12 falsenegative findings were obtained in tumors <4 cm in diameter. Since ex-vivo scintigraphy of resected specimens correctly visualized all but one of these lesions, it is concluded that technical limitations of scintigraphy are the main cause of negative results of radioimmunoimaging with [sup 131]I-labelled antibodies. (orig.)

  15. CEA-targeted nanoparticles allow specific in vivo fluorescent imaging of colorectal cancer models.

    Science.gov (United States)

    Tiernan, James P; Ingram, Nicola; Marston, Gemma; Perry, Sarah L; Rushworth, Jo V; Coletta, P Louise; Millner, Paul A; Jayne, David G; Hughes, Thomas A

    2015-01-01

    Fluorescent imaging of colorectal tumor cells would improve tumor localization and allow intra-operative staging, facilitating stratification of surgical resections thereby improving patient outcomes. We aimed to develop and test fluorescent nanoparticles capable of allowing this in vivo. Dye-doped silica nanoparticles were synthesized. Anti-CEA (carcinoembryonic antigen) or control IgGs were conjugated to nanoparticles using various chemical strategies. Binding of CEA-targeted or control nanoparticles to colorectal cancer cells was quantified in vitro, and in vivo after systemic-delivery to murine xenografts. CEA-targeted, polyamidoamine dendrimer-conjugated, nanoparticles, but not control nanoparticles, allowed strong tumor-specific imaging. We are the first to demonstrate live, specific, in vivo imaging of colorectal cancer cells using antibody-targeted fluorescent nanoparticles. These nanoparticles have potential to allow intra-operative fluorescent visualization of tumor cells.

  16. Overview of CEA research in the field of radionuclides migration; Syntheses des recherches menees par le CEA sur la migration des radionucleides

    Energy Technology Data Exchange (ETDEWEB)

    Poinssot, Ch.; Trotignon, L.; Tevissen, E

    2006-07-01

    This report presents a synthetic status of the researches conducted within the Nuclear Energy Division (CEA/DEN) in the field of radionuclides migration in three specific areas which have been chosen for their representativeness and potential impact: the migration of RN in PWR reactors, the migration of RN from a deep geological repository and the migration processes in the surface environments. In addition, some status is given about more generic research which is conducted in the field of RN speciation in the aqueous phase and at the interfaces and regarding chemistry / transport couplings. Additional information about the human and technical means involved in these fields of research in CEA/DEN is finally given in the Appendix. (authors)

  17. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa.

    Directory of Open Access Journals (Sweden)

    Petra Muenzner

    2016-05-01

    Full Text Available Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa.

  18. Development of radiopharmaceuticals based on aptamers: selection and characterization of DNA aptamers for CEA

    Energy Technology Data Exchange (ETDEWEB)

    Correa, C.R.; Andrade, A.S.R., E-mail: antero@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Augusto-Pinto, L. [BioAptus, Belo Horizonte, MG (Brazil); Goes, A.M., E-mail: goes@icb.ufmg.br [Departamento de Imunologia e Bioquimica. Instituto de Ciencias Biologicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG (Brazil)

    2011-07-01

    Colorectal cancer is among the top four causes of cancer deaths worldwide. Carcinoembryonic antigen (CEA) is a complex intracellular glycoprotein produced by about 90% of colorectal cancers. CEA has been identified as an attractive target for cancer research because of its pattern of expression in the surface cell and its likely functional role in tumorigenesis. Research on the rapid selection of ligands based on the SELEX (systematic evolution of ligands by exponential enrichment) forms the basis for the development of high affinity and high specificity molecules, which can bind to surface determinants of tumour cells, like CEA. The oligonucleotides ligands generated in this technique are called aptamers. Aptamers can potentially find applications as therapeutic or diagnostic tools for many kind of diseases, like a tumor. Aptamers offer low immunogenicity, good tumour penetration, rapid uptake and fast systemic clearance, which favour their application as effective vehicles for radiotherapy. In addition aptamers can be labeled with different radioactive isotopes. The aim of this work was select aptamers binding to the CEA tumor marker. The aptamers are obtained through by SELEX, in which aptamers are selected from a library of random sequences of synthetic DNA by repetitive binding of the oligonucleotides to target molecule (CEA). Analyses of the secondary structure of the aptamers were determined using the m fold toll. Three aptamers were selected to binding assay with target cells. These aptamers were confirmed to have affinity and specific binding for T84 cell line (target cell), showed by confocal imaging. We are currently studying the potential efficacy of these aptamers as targeted radiopharmaceuticals, for use as imaging agents or therapeutic applications. The development of aptamers specific to CEA open new perspectives for colorectal cancer diagnosis and treatment. Acknowledgments: This investigation was supported by the Centro de Desenvolvimento da

  19. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa

    Science.gov (United States)

    Muenzner, Petra; Kengmo Tchoupa, Arnaud; Klauser, Benedikt; Brunner, Thomas; Putze, Johannes; Dobrindt, Ulrich; Hauck, Christof R.

    2016-01-01

    Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA) family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa) proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa. PMID:27171273

  20. Rockfall frequency and influence of meteorological factors on a limestone cliff of the urban area of Grenoble.

    Science.gov (United States)

    D'Amato, Julie; Hantz, Didier; Baillet, Laurent; Guerin, Antoine; Jaboyedoff, Michel

    2015-04-01

    The spatial temporal frequency of rockfall events helps to quantify diffuse rockfall hazard. The influence of meteorological factors can also be studied in order to better know the failure triggering factors, and to predict dangerous periods of the year. Detection and dating of some hundreds of rockfalls has been carried out for the Saint Eynard cliff, which towers above a residential area of the town of Grenoble (French Alps), and which consists of a thinly bedded limestone cliff. The rockfalls have been detected by a diachronic comparison of digital models of the cliff, obtained from annual terrestrial laser scanning. They have been dated by means of a continuous photographic and seismic survey of the cliff. Meteorological data are given by local temperature and rain stations. These data allowed to study the influence of meteorological factors in the failure process. Six hundreds rockfalls (volume 0.005m3 to 1500m3) have been dated by periods of 2 to 11 weeks. The average frequency of the detected rockfalls for the 18 months of survey is 1.0 rockfall per day. The winter periods (with freeze-thaw cycles) clearly show a higher rockfall frequency, up to 1.9 rockfall per day for the most active winter periods. Summer periods show a lower rockfall frequency, between 0.1 and 0.5 rockfall per day. The frequency is close to 0.5 for periods with more rainfall. 126 rockfalls were dated with a precision of 10 min to several hours. For these rockfalls, the average frequency is 0.010 rockfall/h. The frequency is 0.015 rockfall/h for the freezing days (days with negative minimal temperature), 0.029 rockfall/h for the days without freeze but following a freezing day, 0.011 rockfall/h for the days with a rainfall and 0.002 rockfall/h for the other days. Rainfall and freeze-thaw events have also been determined hourly. A rainfall event begins with the beginning of a rainfall, and ends at the beginning of the next 24 hours period without rain. The 24h period has been chosen

  1. Report of transparency and nuclear safety 2007 CEA Fontenay aux Roses; Rapport transparence et securite nucleaire 2007 CEA Fontenay aux Roses

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    This report presents the activities of the CEA Center of Fontenay aux roses for the year 2007. After many years of decommissioning and dismantling of nuclear installations, the Center is now devoted (since 2005) to the development of research programmes on biology and biomedical technologies. The actions concerning the safety, the radiation protection, the significant events, the release control and the environmental impacts and the wastes stored on the center are discussed. (A.L.B.)

  2. Aeroacoustics research in Europe: The CEAS-ASC report on 2003 highlights

    Science.gov (United States)

    Schröder, W.

    2004-11-01

    This is a report on some highlights of aeroacoustics research in Europe in 2003, compiled from information provided to the Aeroacoustics Specialists Committee of the Confederation of European Aerospace Societies (CEAS). The CEAS currently comprises the national Aerospace Societies of France (Association Aéronautique et Astronautique de France), Germany (Deutsche Gesellschaft für Luft- und Raumfahrt), Italy (Associazione Italiana di Aeronautica e Astronautica), The Netherlands (Nederlandse Vereniging voor Luchtvaarttechniek), Spain (Asociación de Ingenieros Aeronáuticos de España), Sweden (Flygtekniska Föreningen), Switzerland (Schweizerische Vereinigung für Flugwissenschaften) and the UK (The Royal Aeronautical Society).

  3. Assessment 2000 and regulation and method. Releases control and environmental survey of the CEA Centers; Bilan 2000 et reglementation et methode. Controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The environment quality around the CEA centers is a major interest of its safety policy. These documents contribute to the public information on the radioactive liquid and gaseous releases of the CEA, according to the ministry authorization. The radioactivity monitoring activity, and the survey methods are also presented. Data analysis from 1996 to 2000, allows to follow the evolution. (A.L.B.)

  4. Carcinoembryonic antigen (CEA) measurement during follow-up for rectal carcinoma is useful even if normal levels exist before surgery. A retrospective study of CEA values in the TME trial

    NARCIS (Netherlands)

    Grossmann, I.; de Bock, G. H.; Kranenbarg, W. M. Meershoek-Klein; de Velde, C. J. H. van; Wiggers, T.

    2007-01-01

    Background: Carcinoembryonic antigen (CEA) as a marker in the follow-up after curative resection of colorectal carcinoma (CRC) is often omitted from follow-up despite guideline recommendations. One reason is the assumption that when a normal CEA value exists before curative resection of CRC, it will

  5. Sensitivity of CA 15-3, CEA and serum HER2 in the early detection of recurrence of breast cancer

    DEFF Research Database (Denmark)

    Eriksen, Ann Christina; Sørensen, Patricia Diana; Jacobsen, Erik Hugger;

    2013-01-01

    The aim of this project was to investigate the sensitivity of CA 15-3, CEA and HER2 in the early diagnosis of metastatic breast cancer.......The aim of this project was to investigate the sensitivity of CA 15-3, CEA and HER2 in the early diagnosis of metastatic breast cancer....

  6. A study on the core analysis methodology for SMART CEA ejection accident-I

    Energy Technology Data Exchange (ETDEWEB)

    Zee, Sung Kyun; Lee, Chung Chan; Kim, Kyo Yoon; Cho, Byung Oh

    1999-04-01

    A methodology to analyze the fuel enthalpy is developed based on MASTER that is a time dependent 3 dimensional core analysis code. Using the proposed methodology, SMART CEA ejection accident is analyzed. Moreover, radiation doses are estimated at the exclusion area boundary and low population zone to confirm the criteria for the accident. (Author). 31 refs., 13 tabs., 18 figs.

  7. Spanish Pre-University Students' Use of English: CEA Results from the University Entrance Examination

    Science.gov (United States)

    Diez-Bedmar, Maria Belen

    2011-01-01

    In this paper an updated overview of the main errors that Spanish students make when writing the English exam in the University Entrance Examination is provided. To do so, a Computer-aided Error Analysis (CEA) (Dagneaux, Denness & Granger, 1998) was conducted on a representative sample of the students who took the exam in June 2008 in Jaen,…

  8. Meeting of Directors and Heads of Department from CEA-Saclay, France

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Left to right: Ph. Pradelles, M. Jacquemet and T. Taylor in discussion during the December visit of Directors and Heads of Department from the Saclay centre of the French atomic energy commission (CEA) to CERN's LHC magnet test facility. Looking on is Yves Lemoigne.

  9. Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

    Science.gov (United States)

    Wang, Wei; Chen, Xiao-Long; Zhao, Shen-Yu; Xu, Yu-Hui; Zhang, Wei-Han; Liu, Kai; Chen, Xin-Zu; Yang, Kun; Zhang, Bo; Chen, Zhi-Xin; Chen, Jia-Ping; Zhou, Zong-Guang; Hu, Jian-Kun

    2016-01-01

    The prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma (GC) has been widely reported and is still under debate. Here, we evaluated the prognostic significance of preoperative serum CA125, CA19-9 and CEA in patients with GC. 1692 patients with GC who underwent gastrectomy were divided into the training (from January 2005 to December 2011, n = 1024) and the validation (from January 2012 to December 2013, n = 668) cohorts. Positive groups of CA125 (> 13.72 U/ml), CA19-9 (> 23.36 U/ml) and CEA (> 4.28 ng/ml) were significantly associated with more advanced clinicopathological traits and worse outcomes than that of negative groups (all P < 0.01). In Cox regression analysis, tumor size (P < 0.001, P = 0.005), pTNM stage (P < 0.001, P < 0.001) and CA125 (P = 0.026, P = 0.005) were independent prognostic factors both in two cohorts. Nomograms of these two cohorts based on the number of positive serum tumor markers (NPTM) were more accurate in prognostic prediction than TNM stage alone. Our findings suggested that elevated preoperative serum CA125, CA19-9 and CEA were associated with more advanced clinicopathological traits and less favorable outcomes. In addition, CA125 as an independent prognostic factor should be further investigated. Nomogram based on NPTM could accurately predict the prognosis of GC patients. PMID:27097114

  10. The study of special killing effect of CD3AK on anti-CEA-positive tumor enhanced by DC loaded with CEA-rV%荷CEA-rV的DC增强CD3AK对CEA阳性肿瘤特异性杀伤作用的研究

    Institute of Scientific and Technical Information of China (English)

    祁岩超; 王新帅; 扬波

    2006-01-01

    Objective: To survey the special killing activity of CD3AK on anti-CEA-positive tumor enhanced by umbilical cord blood dendritic cell (DC) loaded with CEA recombinant vaccinia virus (CEA-rV). Methods: Freshly isolated umbilical blood mononuclear cells (UBMC) were cultivated for 3 h. Suspension cells and attached cells were used to induce CD3AK cells and DC separately. DC was loaded with CEA-rV on the 3rd day to prepare CEA-rV+DC. CD3AK cells were co-cultured with CEA-rV+DC on the 8th day, to prepare CEA-rV+DC+CD3AK. The killing activity of each effector's cell, which included UBMC, CD3AK, DC+CD3AK and CEA-rV+DC+CD3AK, was measured respectively by MTT reduction assay. Results: (1) 4 target cells were confirmed by CEA monoclonal antibody of rabbit anti-human. Lovo and A549 were really CEA positive cell lines, while Bel-7402 and K562 were CEA negative cell lines. (2) It was showed by flow-cytometry that the mature DC cultured at 10th day expressed MHCⅠ, Ⅱ molecules such as CD86, CD80, CD83 and CD40 highly, but CD123 lowly. The expression rates of CD86, CD80, CD83 and CD40 was 82.7%, 51.1%, 57.5% and 69.4%, respectively. The appearances and intra-cellular structures of DC were observed through light and electron microscope. The diameter of mature DC was 15-20 μm presented the irregular morphologic appearance, much prominences and pseudopodium. There were abundant mitochondria and endoplasmic reticulum in DC endochylema. (3) The rates of CD3, CD4, CD8 and CD28 in CD3AK cells group were 2 folds higher than that in UBMC group by FACS.It was said that the numbers of the mature T lymphocyte in CD3AK cells group were much greater than that in UBMC group. (4)The killing activities to 4 target cells of 3 effector's cells, which included CEA-rV+DC+CD3AK, DC+CD3AK and CD3AK, were much greater than that of UBMC (P<0.01). Moreover, comparing with the killing activities of 4 effector's: CEA-rV+DC+CD3AK group > DC+CD3AK group > CD3AK group > UBMC group. It showed that

  11. Dispersion of Radionuclides and Exposure Assessment in Urban Environments: A Joint CEA and LLNL Report

    Energy Technology Data Exchange (ETDEWEB)

    Glascoe, Lee [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gowardhan, Akshay [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lennox, Kristin [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Simpson, Matthew [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Yu, Kristen [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Armand, Patrick [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Duchenne, Christophe [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Mariotte, Frederic [Alternative Energies and Atomic Energy Commission (CEA), Paris (France); Pectorin, Xavier [Alternative Energies and Atomic Energy Commission (CEA), Paris (France)

    2014-12-19

    In the interest of promoting the international exchange of technical expertise, the US Department of Energy’s Office of Emergency Operations (NA-40) and the French Commissariat à l'Energie Atomique et aux énergies alternatives (CEA) requested that the National Atmospheric Release Advisory Center (NARAC) of Lawrence Livermore National Laboratory (LLNL) in Livermore, California host a joint table top exercise with experts in emergency management and atmospheric transport modeling. In this table top exercise, LLNL and CEA compared each other’s flow and dispersion models. The goal of the comparison is to facilitate the exchange of knowledge, capabilities, and practices, and to demonstrate the utility of modeling dispersal at different levels of computational fidelity. Two modeling approaches were examined, a regional scale modeling approach, appropriate for simple terrain and/or very large releases, and an urban scale modeling approach, appropriate for small releases in a city environment. This report is a summary of LLNL and CEA modeling efforts from this exercise. Two different types of LLNL and CEA models were employed in the analysis: urban-scale models (Aeolus CFD at LLNL/NARAC and Parallel- Micro-SWIFT-SPRAY, PMSS, at CEA) for analysis of a 5,000 Ci radiological release and Lagrangian Particle Dispersion Models (LODI at LLNL/NARAC and PSPRAY at CEA) for analysis of a much larger (500,000 Ci) regional radiological release. Two densely-populated urban locations were chosen: Chicago with its high-rise skyline and gridded street network and Paris with its more consistent, lower building height and complex unaligned street network. Each location was considered under early summer daytime and nighttime conditions. Different levels of fidelity were chosen for each scale: (1) lower fidelity mass-consistent diagnostic, intermediate fidelity Navier-Stokes RANS models, and higher fidelity Navier-Stokes LES for urban-scale analysis, and (2) lower-fidelity single

  12. Seismic vulnerability analysis of moderate seismicity areas using in situ experimental techniques: from the building to the city scale ? Application to Grenoble and Pointe-\\`a-Pitre (France)

    CERN Document Server

    Michel, Clotaire

    2009-01-01

    Seismic vulnerability analysis of existing buildings requires basic information on their structural behaviour. The ambient vibrations of buildings and the modal parameters (frequencies, damping ration and modal shapes) that can be extracted from them naturally include the geometry and quality of material in the linear elastic part of their behaviour. The aim of this work is to use this modal information to help the vulnerability assessment. A linear dynamic modal model based on experimental modal parameters is proposed and the fragility curve corresponding to the damage state ?Slight? is built using this model and a simple formula is proposed. This curve is particularly interesting in moderate seismic areas. This methodology is applied to the Grenoble City where ambient vibrations have been recorded in 61 buildings of various types and to the Pointe-\\`a-Pitre City with 7 study-buildings. The fragility curves are developed using the aforementioned methodology. The seismic risk of the study-buildings is discuss...

  13. [Influence of a priori parameters on bayesian relative risks estimations. Spatial distribution of bladder cancer in the urban area of Grenoble].

    Science.gov (United States)

    Colonna, M

    2006-12-01

    Bayesian estimates of disease relative risks is currently the gold standard in disease mapping when the disease is rare and/or when the geographical area is small. Its use has become quite easy with adhoc software. However, the implicit mechanisms of the choices made by the user must be clearly identified. We were interested here in the consequences of the choice of the hyper a priori parameters. We have compared results obtained using various hyper a priori parameters. The consequences of these choices are illustrated through the example of the incidence of bladder cancer among men in the urban area of Grenoble. We show that the risks can appear weak from a statistical point of view but important from an epidemiologic point of view in the presentation of the results.

  14. [Motivations of parents taking their children to the hospital in emergencies. Results of a psychosocial survey at the Regional University Hospital Center of Grenoble].

    Science.gov (United States)

    Marguet, M C; Lejosne, G; Berthier, N; Bost, M

    1988-01-01

    A psycho-social survey by questionnaire was conducted among parents accompanying their children to the Pediatric Emergency Ward of the Medical Center of Grenoble, in order to identify the motivations of those who do not seek a medical advice prior to their coming to the hospital. From this survey, several motivating factors were identified: an economical factor, the difficulty to rapidly call a physician, the place of residence, an insufficient knowledge of the medical services, the familiarity of parents with the hospital, the advice of relatives, the anxiety caused by the child's illness and the comforting image of the hospital. In a synthetic analysis, several types of parents are distinguished according to their behavior.

  15. Variation of uptake of anti-CEA monoclonal antibody with tumor type and mass

    Energy Technology Data Exchange (ETDEWEB)

    Williams, L.E.; Philben, V.J.; Jakowatz, J.G.; Beatty, B.G.; Vlahos, W.G.; Paxton, R.J.; Shively, J.E.; Beatty, J.D.

    1985-05-01

    A nude mouse model xenografted with 3 human tumor (T) was studied with an anti-carcinoembryonic (..cap alpha..-CEA) monoclonal antibody (MoAb). The MoAb was labeled with In-111 using a bi-functional chelation technique. In vitro cross-reactivity with human blood (B) and liver (L) cells was minimal. Human colon tumors were WIDR, SW403 an LS174T. The murine carcinoma EMT6 was used as a control. In all cases only 62.5 ngm of ..cap alpha..-CEA charged at 10 ..mu..Ci/..mu..gm was given to each animal. The corresponding value in humans, 200 ..mu..gm, is probably subimmunogenic. Organ distribution in percent injected dose/gm (% ID/gm) and images were obtained at 48 h post-injection of the MoAb. CEA levels (mgm/gm of T) were measured for each tumor using the same MoAb (T 84.66). Variation of % ID/gm with LS174T mass (m) was also determined. Uptake by EMT6 was 2.4 +- 0.2 % ID/gm. LS174T uptake varied approximately as the inverse of tumor mass. The authors conclude that tumor accumulation of ..cap alpha..-CEA MoAb is not directly correlated with the amount of CEA in the lesion. The best uptake, T/B and T/L values occurred with LS174T; this was also borne out by the 48 h images. Because of the smaller average SW403 mass, this result cannot readily be explained as a tumor size effect.

  16. One-year study of polycyclic aromatic compounds at an urban site in Grenoble (France): Seasonal variations, gas/particle partitioning and cancer risk estimation.

    Science.gov (United States)

    Tomaz, Sophie; Shahpoury, Pourya; Jaffrezo, Jean-Luc; Lammel, Gerhard; Perraudin, Emilie; Villenave, Eric; Albinet, Alexandre

    2016-09-15

    21 PAHs, 27 oxy-PAHs and 32 nitro-PAHs were measured every third day over a year in both gaseous (G) and particulate PM10 (P) phases in ambient air of Grenoble (France). Mean total concentrations (G+P) of PAHs and oxy-PAHs were in the same range and about 10ngm(-3). Nitro-PAHs were 50 to 100 times less concentrated averaging 100pgm(-3). Polycyclic aromatic compound (PAC) concentrations were 5 to 7 times higher in "cold" period (October to March) than in "warm" period (April to September). Seasonal variations may be explained by higher primary emissions from residential heating, especially biomass burning in "cold" season. Meteorological conditions and influence of the geomorphology around Grenoble, with the formation of thermal inversion layers leading to the stagnation of pollutants, were additional key parameters. Maximum individual PAC concentrations were observed during two PM10 pollution events in December and February-March. Chemical processes and secondary formation of oxy- and nitro-PAH were probably enhanced by the accumulation of the pollutants during these events. PAC gas/particle partitioning depended on compound molecular weight and vapour pressure. Gas/particle partitioning of oxy- and nitro-PAHs were evaluated using a multi-phase poly-parameter linear free energy relationship model. The PAC cancer risk was assessed using toxic equivalency factors available in the literature (19 PAHs, 10 nitro-PAHs and 1 oxy-PAH). Overall, particle-bound PACs contributed about 76% of the cancer risk. While PAHs accounted for most of the total PAC cancer risk, oxy- and nitro-PAHs could account for up to 24%. The risk quantification across substance classes is limited by toxicological data availability.

  17. The evaluation of the nuclear facilities safety at the CEA from 1999 to 2001; Le bilan de la surete des installations nucleaires du CEA du 1999 a 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-11-01

    The aim of this document is the presentation of an evaluation of the problems and the safety methods in the concerned period. The first chapter presents the nuclear safety in the CEA. The second chapter is devoted to the organization and the quality for the safety: liabilities, audits, relations with the safety authorities and with the public. The chapters three and four deal respectively with the methodological and technical abilities supporting the exploitation teams and with the nuclear safety projects. The last chapter presents the experiments and events from 1999 to 2001. (A.L.B.)

  18. The CEA and alternative energies. 8 April 2010 press conference; Le CEA et les energies alternatives. Conference de presse du 8 avril 2010

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This document presents the CEA's strategy in terms of alternative energies and the various implemented research programs which mainly concern the building sector and the transport sector. After a recall of the energy and climate context, a presentation of the NTE program (Nouvelles Technologies de l'Energie, new energy technologies), the different topics and projects are presented: photovoltaic solar energy and its integration in building; batteries, hydrogen and fuel cells for applications in transports; second-generation bio-fuels.

  19. Progress of the BT-EdF-CEA project. The lithium polymer battery; Avancees du projet BT-EdF-CEA. Batterie lithium polymere

    Energy Technology Data Exchange (ETDEWEB)

    Marginedes, D.; Majastre, H. [Bollore Technologies, 29 - Quimper (France); Baudry, P.; Lascaud, S. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches; Bloch, D.; Lebrun, N. [CEA Grenoble, CEREM, 38 (France)

    1996-12-31

    The lithium-polymer energy storage technology requires the production of thin films of huge surface. The BT-EdF-CEA consortium has studied the various manufacturing techniques of these films and their assembly. The process was chosen according to its productivity, low expensiveness, ecological impact and energy performances with capacities reaching 40 Ah. This paper explains: the objectives and specifications of the project, the advantage of the consortium and the role of the different partners, the results (coating, dry extrusion and battery element manufacturing techniques), and the electrochemical performances of the elements. (J.S.)

  20. Producing energy without greenhouse effect gases: the CEA action; Produire de l'energie sans gaz a effet de serre: l'action du CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    Major actor in the domain of new energy technologies, the CEA manages the french research on the hydrogen and the fuel cells. It is also implied with INES (National Institute for the Solar Energy) in the photovoltaic and thermal solar. With the IFP (French Petroleum Institute), it manages research on biofuels. Of course the thermonuclear fusion, for the development of the energy of the future, is in its research program too. This information document presents the possibilities of these energies and the associated research programs. (A.L.B.)

  1. Hookah smoking and cancer: carcinoembryonic antigen (CEA levels in exclusive/ever hookah smokers

    Directory of Open Access Journals (Sweden)

    Chaouachi Kamal

    2008-05-01

    Full Text Available Abstract Background We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (cigarettes, bidis, etc.. Objectives To find serum CEA levels in ever/exclusive hookah smokers, i.e. those who smoked only hookah (no cigarettes, bidis, etc., prepared between 1 and 4 times a day with a quantity of up to 120 g of a tobacco-molasses mixture each (i.e. the tobacco weight equivalent of up to 60 cigarettes of 1 g each and consumed in 1 to 8 sessions. Methods Enhanced chemiluminescent immunometric technique was applied to measure CEA levels in serum samples from 59 exclusive male smokers with age ranging from 20–80 years (mean = 58.8 ± 14.7 years and 8–65 years of smoking (mean = 37.7 ± 16.8. 36 non-smokers served as controls. Subjects were divided into 3 groups according to the number of preparations; the number of sessions and the total daily smoking time: Light (1; 1; ≤ 20 minutes; Medium (1–3; 1–3; >20 min to ≤ 2 hrs and Heavy smokers (2–4; 3–8; >2 hrs to ≤ 6 hrs. Because of the nature of distribution of CEA levels among our individuals, Wilcoxon's rank sum two-sample test was applied to compare the variables. Results The overall CEA levels in exclusive hookah smokers (mean: 3.58 ± 2.61 ng/ml; n = 59 were not significantly different (p ≤ 0.0937 from the levels in non-smokers (2.35 ± 0.71 ng/ml. Mean levels in light, medium and heavy smokers were: 1.06 ± 0.492 ng/ml (n = 5; 2.52 ± 1.15 ng/ml (n = 28 and 5.11 ± 3.08 ng/ml (n = 26 respectively. The levels in medium smokers and non-smokers were also not significantly different (p ≤ 0.9138. In heavy smokers, the CEA levels were significantly higher than in non-smokers (p ≤ 0.0001567. Conclusion Overall CEA levels in exclusive hookah

  2. Carcinoembryonic antigen (CEA)-based cancer vaccines: recent patents and antitumor effects from experimental models to clinical trials.

    Science.gov (United States)

    Turriziani, Mario; Fantini, Massimo; Benvenuto, Monica; Izzi, Valerio; Masuelli, Laura; Sacchetti, Pamela; Modesti, Andrea; Bei, Roberto

    2012-09-01

    Carcinoembryonic antigen (CEA), a glycosylated protein of MW 180 kDa, is overexpressed in a wide range of human carcinomas, including colorectal, gastric, pancreatic, non-small cell lung and breast carcinomas. Accordingly, CEA is one of several oncofetal antigens that may serve as a target for active anti-cancer specific immunotherapy. Experimental results obtained by employing animal models have supported the design of clinical trials using a CEA-based vaccine for the treatment of different types of human cancers. This review reports findings from experimental models and clinical evidence on the use of a CEA-based vaccine for the treatment of cancer patients. Among the diverse CEA-based cancer vaccines, DCs- and recombinant viruses-based vaccines seem the most valid. However, although vaccination was shown to induce a strong immune response to CEA, resulting in a delay in tumor progression and prolonged survival in some cancer patients, it failed to eradicate the tumor in most cases, owing partly to the negative effect exerted by the tumor microenvironment on immune response. Thus, in order to develop more efficient and effective cancer vaccines, it is necessary to design new clinical trials combining cancer vaccines with chemotherapy, radiotherapy and drugs which target those factors responsible for immunosuppression of immune cells. This review also discusses relevant patents relating to the use of CEA as a cancer vaccine.

  3. Possible association of CEA expression with oxyphilic change but not with C-cell hyperplasia in Hashimoto's thyroiditis.

    Science.gov (United States)

    Gakiopoulou, Hariklia; Litsiou, Eleni; Valaris, Konstantinos; Balafoutas, Dimitrios; Patsouris, Efstratios; Tseleni-Balafouta, Sofia

    2010-01-01

    Reactive C-cell hyperplasia (CCH) has been observed in cases of autoimmune Hashimoto's thyroiditis; however, its occurrence in Graves' disease, the other major autoimmune disorder, has not yet been investigated. On the other hand, although Carcinoembryonic Antigen (CEA) serum levels have been reported elevated in patients with autoimmune thyroid disease (ATD), the source of CEA production at the cellular level is not elucidated. The aim of this study was to evaluate CCH and CEA immunohistochemical expression and comparatively analyze them in 136 ATD cases (107 Hashimoto's and 29 Graves' disease cases) and 20 cases of nodular hyperplasia (NH). Immunohistochemistry using monoclonal antibodies to chromogranin and CEA was performed. A scoring system for CCH and semiquantitative evaluation for CEA expression were applied. C-cell hyperplasia was absent in NH cases. In contrast, it was detected in 11% of ATD cases being more frequently observed in Hashimoto's (12.1%) than Graves' disease (6.8%) CCH associated to male sex and older age of Hashimoto's patients. CEA was detected only in ATD cases (33.8%), in C-cells and in follicular cells as well, being more frequently detected in Graves' (44.8%) than Hashimoto's (30.8%) disease. An interesting finding was an emerging possible association of CEA expression with oxyphilic change but not with C-cell hyperplasia in Hashimoto's thyroiditis. No significant correlation was established between CCH and CEA follicular cell expression in neither disease. In conclusion, C-cell hyperplasia and CEA expression may be encountered in the setting of Hashimoto's thyroiditis and Graves' disease.

  4. Plasma TIMP-1 and CEA as markers for detection of primary colorectal cancer

    DEFF Research Database (Denmark)

    Christensen, Ib Jarle; Brünner, Nils; Dowell, Barry

    2015-01-01

    BACKGROUND/AIM: The combination of plasma tissue inhibitor of metalloproteinases-1 (1) and CEA has been shown to have utility in early detection of colorectal cancer (2). A prospective study was performed to validate previous findings. PATIENTS AND METHODS: Individuals undergoing large bowel...... was detected in 32 individuals, 24 with colonic cancer (CC) and 8 with rectal cancer (RC). Other findings were 265 with adenomas and 889 with non-neoplastic pathology. The biomarker levels were elevated in plasma from patients with CRC, but also from patients with various co-morbidities compared to individuals...... endoscopy were prospectively included (N=1965). Baseline data and co-morbidity were recorded. The primary end-point was the detection of CRC. Plasma was obtained before endoscopy and TIMP-1 and CEA levels were determined using an automated analysis platform when all samples were collected. RESULTS: CRC...

  5. Fusion technology. Annual report of the Association CEA/EURATOM 1997

    Energy Technology Data Exchange (ETDEWEB)

    Magaud, P.; Le Vagueres, F

    1998-12-31

    The research and development work performed by the French EURATOM-CEA Association for fusion technology is part of the Fusion Programme of the European Community. This report compiles the work carried out during the year 1997 as follows: The ITER CEA activities and related developments are described in the first section (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); The second part is dedicated to the Long Term activities as Blankets and material developments, long term safety, socio-economic problem; The Underlying Technology activities are compiled in the third part of this report (plasma facing components, vacuum vessel and shield, magnets, remote handling, safety); And the fourth part describes the inertial confinement studies. (K.A.)

  6. Efecto del choque térmico simulando la acción del fuego, en la germinación de Fabáceas y Poáceas forrajeras de las Sierras Chicas de Córdoba

    OpenAIRE

    Martinat, Jimena Elisa

    2012-01-01

    Tesis (Magister en Ciencias Agropecuarias. Mención: Tecnología de Semillas)--UNC- Facultad de Ciencias Agropecuarias, 2012. Con el objetivo de conocer la respuesta germinativa de semillas de Galactia latisiliqua var. latisiliqua y Rhynchosia edulis (Fabáceas) y de Setaria lachnea y Eragrostis tenuifolia (Poáceas), forrajeras espontáneas de las Sierras Chicas de Córdoba- Argentina, para reproducir las condiciones de temperatura a las que son expuestas durante ...

  7. Thermal hydraulic characteristics study of prototype NET and CEA cable-in-conduit conductors (CICCs)

    Energy Technology Data Exchange (ETDEWEB)

    Maekawa, Ryuji

    1995-10-31

    The thermal hydraulic characteristics of low temperature helium in a Cable-in-Conduit Conductor (CICC) significantly affects the overall design and performance of the associated large scale superconducting magnet system. It is essential to understand the transient and steady state behavior of the helium in the conductor. Throughout the development of CICCs, the reduction of flow impedance has been one of the key factors to improving the overall pressure drop. The newly developed CICC for the ITER project has a hybrid cooling scheme: a central channel that is surrounded by bundles, for which the thermal hydraulic characteristics are not well understood. This thesis describes an experimental and analytical investigation of thermal hydraulic characteristics of low temperature helium in conventional and hybrid CICCS. Pressure drop measurements for both NET and CEA conductors have been conducted, using low temperature helium and liquid nitrogen to obtain a range of Reynolds numbers. The results are correlated with classical friction factor and Reynolds number analysis. The flow impedance reduction of the CEA conductor is described by measures of a developed flow model. Thermally induced flow in the CEA conductor has been studied with an inductive heating method. The induced velocity in the central channel is measured by a Pitot tube with steady state Reynolds number up to {approximately}7000. The transient pressure wave propagation has been recorded with pressure transducers placed equally along the conductor. The supercritical helium temperature in the central channel has been measured with the thermometer probe. However, the reduction of the central channel area significantly affects the overall thermal hydraulic characteristics of the conductor. The results suggest the importance of the central channel. A transient heat transfer experiment studied the.transverse heat transfer mechanism in the CEA conductor. The temperatures in the central channel and bundle region

  8. EURATOM-CEA association contributions to the 21st symposium on fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Garin, P.; Grosman, A.; Beaumont, B. [and others

    2000-11-01

    The 27 contributions of EURATOM-Cea association have been gathered with 6 additional papers and 1 invited paper in this document. Most papers concern Tore-Supra and deal with the ergodic divertor, particle injection, impedance concept for ICRF antennas, low hybrid current drive, RF systems, the 118 GHz ECRH experiment, the inner first wall, improved vacuum vessel protection, pellet injection, material activation, and the CIEL project. 3 of the additional papers concern the model coil of ITER.

  9. Experimental results from the CEA Reactor Physics Programme on MARIUS III

    Energy Technology Data Exchange (ETDEWEB)

    Bosser, R.; Langlet, G.; Morier, F.

    1971-01-15

    A programme of experimental studies on the physics of HTR lattices was proposed in 1968. Under the authority of the EDF-CEA joint comittee, decision to achieve this programmes was taken in Jyly 1969. Less than one year after, MARIUS III had its first divergence in its new configuration and the experiments began in August 1970. After preliminary experiments, phase one of the programme was achieved in October, November and December 1970. Experimental results are presented.

  10. Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients

    Institute of Scientific and Technical Information of China (English)

    Aikaterini; Tsouma; Chrysanthi; Aggeli; Panagiotis; Lembessis; George; N; Zografos; Dimitris; P; Korkolis; Dimitrios; Pectasides; Maria; Skondra; Nikolaos; Pissimissis; Anastasia; Tzonou; Michael; Koutsilieris

    2010-01-01

    AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting cir-culating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors' clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved det...

  11. One-year study of polycyclic aromatic compounds at an urban site in Grenoble (France): Seasonal variations, gas/particle partitioning and cancer risk estimation

    Energy Technology Data Exchange (ETDEWEB)

    Tomaz, Sophie [Institut National de l' Environnement industriel et des RISques (INERIS), Parc Technologique Alata BP2, 60550 Verneuil en Halatte (France); CNRS, EPOC, UMR 5805, F-33405 Talence Cedex (France); Université de Bordeaux, EPOC, UMR 5805, F-33405, Talence Cedex (France); Shahpoury, Pourya [Max Planck Institute for Chemistry, Multiphase Chemistry Department, Mainz (Germany); Jaffrezo, Jean-Luc [Laboratoire de Glaciologie et Géophysiques de l' Environnement (LGGE), Université de Grenoble-Alpes/CNRS, Grenoble (France); Lammel, Gerhard [Max Planck Institute for Chemistry, Multiphase Chemistry Department, Mainz (Germany); Masaryk University, Research Centre for Toxic Compounds in the Environment, Brno (Czech Republic); Perraudin, Emilie; Villenave, Eric [CNRS, EPOC, UMR 5805, F-33405 Talence Cedex (France); Université de Bordeaux, EPOC, UMR 5805, F-33405, Talence Cedex (France); Albinet, Alexandre, E-mail: alexandre.albinet@gmail.com [Institut National de l' Environnement industriel et des RISques (INERIS), Parc Technologique Alata BP2, 60550 Verneuil en Halatte (France)

    2016-09-15

    21 PAHs, 27 oxy-PAHs and 32 nitro-PAHs were measured every third day over a year in both gaseous (G) and particulate PM{sub 10} (P) phases in ambient air of Grenoble (France). Mean total concentrations (G + P) of PAHs and oxy-PAHs were in the same range and about 10 ng m{sup −3}. Nitro-PAHs were 50 to 100 times less concentrated averaging 100 pg m{sup −3}. Polycyclic aromatic compound (PAC) concentrations were 5 to 7 times higher in “cold” period (October to March) than in “warm” period (April to September). Seasonal variations may be explained by higher primary emissions from residential heating, especially biomass burning in “cold” season. Meteorological conditions and influence of the geomorphology around Grenoble, with the formation of thermal inversion layers leading to the stagnation of pollutants, were additional key parameters. Maximum individual PAC concentrations were observed during two PM{sub 10} pollution events in December and February–March. Chemical processes and secondary formation of oxy- and nitro-PAH were probably enhanced by the accumulation of the pollutants during these events. PAC gas/particle partitioning depended on compound molecular weight and vapour pressure. Gas/particle partitioning of oxy- and nitro-PAHs were evaluated using a multi-phase poly-parameter linear free energy relationship model. The PAC cancer risk was assessed using toxic equivalency factors available in the literature (19 PAHs, 10 nitro-PAHs and 1 oxy-PAH). Overall, particle-bound PACs contributed about 76% of the cancer risk. While PAHs accounted for most of the total PAC cancer risk, oxy- and nitro-PAHs could account for up to 24%. The risk quantification across substance classes is limited by toxicological data availability. - Highlights: • The most comprehensive study about PAH, nitro- and oxy-PAH in ambient air. • 80 species studied in gaseous and particle phases over a year at French urban site. • Concentration seasonality governed by

  12. EXPLORE ON DIAGNOSTIC AND PROGNOSTIC VALUES OF EXTRAHEPATIC CHOLANGIOCARCINOMA:UTILITY OF SERUM CA19-9 AND SERUM CEA

    Institute of Scientific and Technical Information of China (English)

    秦兴雷; 王作仁; 鲁敏; 王林; 何铨儒

    2004-01-01

    Objective To evaluate the validity of a serum carbohydrate antigen 19-9(CA19-9) determination in the diagnosis of extrahepatic cholangiocarcinoma(EHCC). Methods Serum CA19-9 concentration and serum carcinoembryonic antigen(CEA) concentration were prospectively measured by an immunoradiometric assay without knowledge of the clinical diagnosis in patients with EHCC (n=51), benign biliary diseases (n=42), and healthy individuals (n=15). Using a receiver operating characteristic (ROC) curve define a new strategy for interpreting CA19-9 and CEA in EHCC. Results The sensitivity of CA19-9 and CEA in diagnosing EHCC were 86.3% (44/51) and 25.5%(13/51), respectively. When compared with the benign biliary diseases group, the true negative rates of serum CA19-9 and serum CEA were 85.7% (36/42) and 95.2%(40/42), respectively. The false positive rates of serum CA19-9 and serum CEA were 14.3 %( 6/42) and 4.8 %( 2/42), whereas the accuracy of serum CA19-9 and serum CEA were 57.0%(53/93) and 86.0%(80/93), respectively. Serum CA19-9 concentration and serum CEA concentration were significantly elevated (P0.05), respectively. In 22 patients undergoing curative resection of EHCC, the mean serum CA19-9 concentration decreased from preoperative level of (456.6±120.4) kU·L-1 to postoperative level (62.8±17.3) kU·L-1(P<0.001). The outcomes showed that serum CA19-9 had greater diagnosis performances than serum CEA. Conclusion Serum CA19-9 is an effective tumor marker in diagnosing of cholangiocarcinoma, deciding whether the tumor has been radically resected and monitoring effect of treatment

  13. Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact comparative oncology studies.

    Science.gov (United States)

    Weichselbaumer, Marlene; Willmann, Michael; Reifinger, Martin; Singer, Josef; Bajna, Erika; Sobanov, Yuriy; Mechtcherikova, Diana; Selzer, Edgar; Thalhammer, Johann G.; Kammerer, Robert; Jensen-Jarolim, Erika

    2011-01-01

    Comparative oncology aims at speeding up developments for both, human and companion animal cancer patients. Following this line, carcinoembryonic antigen (CEA, CEACAM5) could be a therapeutic target not only for human but also for canine (Canis lupus familiaris; dog) patients. CEACAM5 interacts with CEA-receptor (CEAR) in the cytoplasm of human cancer cells. Our aim was, therefore, to phylogenetically verify the antigenic relationship of CEACAM molecules and CEAR in human and canine cancer. Anti-human CEACAM5 antibody Col-1, previously being applied for cancer diagnosis in dogs, immunohistochemically reacted to 23 out of 30 canine mammary cancer samples. In immunoblot analyses Col-1 specifically detected human CEACAM5 at 180 kDa in human colon cancer cells HT29, and the canine antigen at 60, 120, or 180 kDa in CF33 and CF41 mammary carcinoma cells as well as in spontaneous mammary tumors. While according to phylogenicity canine CEACAM1 molecules should be most closely related to human CEACAM5, Col-1 did not react with canine CEACAM1, -23, -24, -25, -28 or -30 transfected to canine TLM-1 cells. By flow cytometry the Col-1 target molecule was localized intracellularly in canine CF33 and CF41 cells, in contrast to membranous and cytoplasmic expression of human CEACAM5 in HT29. Col-1 incubation had neither effect on canine nor human cancer cell proliferation. Yet, Col-1 treatment decreased AKT-phosphorylation in canine CF33 cells possibly suggestive of anti-apoptotic function, whereas Col-1 increased AKT-phosphorylation in human HT29 cells. We report further a 99% amino acid similarity of human and canine CEA receptor (CEAR) within the phylogenetic tree. CEAR could be detected in four canine cancer cell lines by immunoblot and intracellularly in 10 out of 10 mammary cancer specimens from dog by immunohistochemistry. Whether the specific canine Col-1 target molecule may as functional analogue to human CEACAM5 act as ligand to canine CEAR, remains to be defined. This

  14. CEA develops organic photovoltaic cells that might replace silicon cells; La promesse du plastique. Le CEA developpe des cellules photovoltaiques organiques qui pourraient detroner le silicium

    Energy Technology Data Exchange (ETDEWEB)

    Donnars, O.

    2003-01-01

    The program ''plastic photovoltaic solar cells'' was launched in june 2002 at LCOF (laboratory of functional organic components - CEA). The aim of this program is to show the feasibility of efficient organic photovoltaic cells. At the moment the most efficient organic cells reach a conversion rate of 3,5 % compared to the average value of 16 % for silicon cells. This program sets a term of 4 years to reach a conversion rate of 5 % and an operating life of 5000 hours. Plastics (or polymers) are less expensive than silicon, are available on an unlimited basis and are environment friendly. Plastics are easy to handle and a sole technology (serigraphy) is necessary for all the stages of the fabrication process of the organic cells: serigraphy technology is used for the deposition of the substrate, of the material in which the conversion takes place, and of the protective skin. (A.C.)

  15. Lithium/polymer batteries. Safety approach of the BT-EDF-CEA project; Accumulateurs lithium/polymere. Demarche securite du projet BT-EDF-CEA

    Energy Technology Data Exchange (ETDEWEB)

    Lascaud, S.; Baudry, P. [Electricite de France, 77 - Moret sur Loing (France). Direction des Etudes et Recherches; Majastre, H. [Bollore Technologies, 29 - Quimper (France); Bloch, D. [CEAGrenoble, CEREM, 38 (France)

    1996-12-31

    The BT-EdF-CEA consortium for the development and the performance improvement of lithium/polymer batteries has carried out a safety analysis of the industrial risk and the risk for users linked with this new technology. The process chosen for the manufacturing of lithium/polymer batteries does not generate any particular risk of personnel or environmental contamination. Security tests have permitted to observe and analyze the behaviour of 4 Ah elements during thermal shocks, perforation and crushing, and during external short-circuit on 20 Ah elements. These tests demonstrate the great thermal stability and the excellent behaviour of batteries in the case of partial destruction. (J.S.) 2 refs.

  16. Partial interruption of the inferior vena cava: ten-year evolution in protocols at Grenoble University Hospital. Study of 621 patients.

    Science.gov (United States)

    Bosson, J L; Olinic, D; Franco, G; Pichot, O; Magne, J L; Carpentier, P; Franco, A

    1995-01-01

    An evolution in protocols regarding indications and modalities for Partial Interruption of the Inferior Vena Cava (PIIVC) on 621 patients at Grenoble University Hospital is reported and the influence of new methods in diagnosis (vascular sonography) and therapy (percutaneous filters) is assessed. This comparative study covers the intervals from 1982-1984 (Period A - 333 patients), and 1989-1991 (Period B - 288 patients). The percentage of patients with venous thromboembolic disease who underwent PIIVC clearly decreased (21.8% in period A vs. 13% in period B, p < 0.01). The incidence of what are currently miscalled "prophylactic", but are in fact adjunctive indications also diminished (115 patients in period A, or 34.5% of the PIIVC cases vs. 60 patients in period B, or 20.8% of the PIIVC cases, p < 0.05). There was a reduction in the use of Miles caval clips (59 patients or 17.7% for period A vs. 34 patients or 11.8% for period B, p < 0.05). Although there has been an increase in the use of percutaneous caval filters, the use of percutaneous filters has not lead to an increase in the real rate of PIIVC performed by an Angiology Unit with a large experience in the diagnosis and follow-up of patients with venous thromboembolic disease.

  17. [The issue of dialysis withdrawal and palliative cares. A 3-year retrospective study carried out at Grenoble university teaching hospital development of a decision-making tool].

    Science.gov (United States)

    Jarrin, Guillemette; Maurizi-Balzan, Jocelyne; Laval, Guillemette

    2007-07-01

    Dialysis-related constraints encourage questioning about discontinuation of treatment. In France, the 04/22/2005 law, related to patients' rights and end-of-life issues, defines bounds to treatment withdrawal, authorizing it in specific conditions, to avoid foolish obstinacy. Shortly before the publication of this law, a study has been conducted at Grenoble University Teaching Hospital, involving 31 patients followed by the dialysis service and the palliative care service, in order to analyse the circumstances in which withdrawals from dialysis happen. These patients were old and their general condition was very poor. After initiation of the questioning, treatment was removed in older patients and in those who had been dialysed for short time, which suggests they may have poor adaption to the treatment. No dialysis withdrawal was ever decided without the patient consent or without his nearest and dearest consent. After multidisciplinary discussions, a decision-making tool for dialysis withdrawal has been developed, with a view to be a starting point in the thinking process, for each decision to be adapted to each situation. This tool emphasizes the importance of time and collegial consultation in the decision-making process. It points out to that the decision lies with the referent nephrologist. After withdrawing dialysis, palliative cares must be implemented, since stopping the treatment does not mean stopping cares.

  18. [Socioeconomic incidences and prognostic factors of low back pain caused by occupational injuries among the hospital personnel of Grenoble University Hospital Center].

    Science.gov (United States)

    Troussier, B; Lamalle, Y; Charruel, C; Rachidi, Y; Jiguet, M; Vidal, F; Kern, A; De Gaudemaris, R; Phelip, X

    1993-02-01

    Low back pain is generally believed to be common among hospital employees. This cross-sectional, retrospective study was carried out to determine the annual incidence of low back pain ascribable to occupational injuries in hospital employees and to evaluate factors influencing the prognosis of these injuries. In 1989, 70 employees working at the Grenoble Teaching Hospital (GTH) reported an occupational injury responsible for low back pain. Each of these employees filled out an epidemiological questionnaire during a routine evaluation by a rheumatologist. Overall annual incidence of occupational injuries with subsequent low back pain was 1.9% among GTH employees. Higher incidences were seen among employees whose occupations involved patient transfer, as well as among nursing assistants. Activities associated with an increased risk of low back pain included handling of patients or objects and work requiring prolonged periods in uncomfortable positions or in the standing position. A previous history of low back disease and a longer period of time in the current work were also associated with an increased risk of low back pain. Characteristic clinical profiles of patients with low back pain subsequent to occupational injury were determined by occupation and type of hospital department. The analysis of long-duration absence from work and long-term consequences on career confirmed the significant adverse socioeconomic impact of these injuries.

  19. CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico CA72-4 and CEA in serum and peritoneal washing in gastric cancer

    Directory of Open Access Journals (Sweden)

    Sandra MANDORWSKI

    2002-03-01

    Full Text Available Racional - O tratamento e o prognóstico dos pacientes com câncer gástrico dependem, principalmente, do estádio clínico. Os marcadores tumorais séricos e do lavado peritonial podem auxiliar a avaliar o risco de recurrência da doença. Casuística e Métodos - Quarenta pacientes com câncer gástrico (11 estádio I ou II e 29 estádio III ou IV e 24 com doença benigna foram estudados prospectivamente. Todos os doentes foram submetidos a laparotomia. O sangue e o lavado peritonial foram colhidos durante o ato cirúrgico, antes da retirada do tumor, para determinação dos marcadores CEA e CA72-4. Resultados - Vinte e cinco por cento e 47,5% dos pacientes com câncer gástrico apresentam elevação dos níveis séricos de CEA e CA72-4. Através das curvas ROC definiram-se os valores de corte dos marcadores no lavado peritonial. Através destas curvas, observaram-se que 60% e 57,5% apresentavam CEA e CA72-4 elevado, respectivamente no grupo com câncer gástrico. Os valores de CEA e CA72-4 foram maiores nos pacientes estádios III e IV. No lavado peritonial, os níveis de CEA foram maiores nos doentes com tumores T3-4. Os valores de CA72-4 no lavado peritonial diferenciaram o grupo controle do grupo com câncer gástrico. Conclusão - O CA72-4 foi o marcador sérico mais sensível no diagnóstico de câncer gástrico. Entretanto, no lavado peritonial, o marcador mais sensível foi o CEA. Os valores de CEA foram superiores nos tumores que ultrapassam a serosa e inferiores nos tumores que se restringem a mucosa e muscular.Background - The treatment and the prognosis of gastric cancer patients depends mainly on clinical stage. Serum and peritoneal tumoral markers levels can be helpful to evaluate individual risk for recurrence. Aims - To evaluate the sensibility of the tumoral markers in the serum and in the peritoneal washing on diagnosis of gastric cancer. Patients and Methods - Forty patients with adenocarcinoma of the stomach (11 stage I or

  20. Detection of CEA mRNA on non-small lung cancer and it's significance

    Directory of Open Access Journals (Sweden)

    Guowen WANG

    2008-10-01

    Full Text Available Background and objective In recent years, many studies on micrometastasis in non-small cell lung cancer (NSCLC have been reported, this study is to investigate the effect of operation on micrometastasis from NSCLC andevaluate the relation between micrometastasis and clincopathological parameters. Methods The blood samples were taken from 70 cases of NSCLC and 18 patients with benign diseases at 3 intervals during the operation from peripheral vein. The transcription of carcinoembryonic antigen messenger ribonucleic acid (CEA mRNA was assayed by means of nested reverse transcriptase polymerase chain reaction (RT-PCR and micro-fluid chip. Results The CEA mRNA positive rates of all 3 time spots were as follows: 50% at beginning of the operation (Time 1, 62.8% at ligating the pulmonary vein (Time 2 and 57.1% at 1 h after ligating pulmonary vein (Time 3. There is significant difference between Time 1 and Time 2 (χ2=7.114, P <0.05. The positive rates of well-differentiation and middle-differentiation, stage Ⅰ and state Ⅱ, Tis, T1 and T2, N0 were significant less than non-differentiation and low-differentiation, stage Ⅲ and state Ⅳ, T3 and T4, N1,N2 and N3, respectively. No negative control samples was found to be positive, and no positive control samples was found to be negative. The sensitivity of our test was 10 cells/mL. Conclusion The cancer cells dissemination during operation was demonstrated indirectly in our study, the time of pulmonary vein ligation (earlier or later may affect the quantity of tumor cells released into circulation; The patients with lower differentiation, advanced TNM stage, larger tumor size and metastasis of lymph node have higher rates of metastasis in peripheral, so the detection of CEA mRNA can guide the therapy of NSCLC to a certain extent.

  1. Benchmark Cea - AREVA NP - EDF of the corrosion facilities for VHTR material testing

    Energy Technology Data Exchange (ETDEWEB)

    Cabet, C. [CEA Saclay, Dept. de Physico-Chimie (DEN/DPC/SCCME), 91 - Gif sur Yvette (France); Terlain, A.; Seran, J.L.; Girardin, G.; Kaczorowski, D. [CEA Saclay, Dept. des Materiaux pour le Nucleaire (DEN/DMN), 91 - Gif-sur-Yvette (France); Blat, M. [AREVA NP - NTC-F, Technical Center Le Creusot, 71 - Le Creusot (France); Dubiez Le Goff, S. [Electricite de France (EDF R and D), Chemistry and Corrosion group, MMC Dept., 77 - Moret sur Loing (France)

    2007-07-01

    Within the framework of the ANTARES program, the French Cea, AREVA-NP and EDF have launched a joint program on metallic materials for application in innovative Very High Temperature Reactors (VHTR). Since corrosion is highly sensitive to environmental conditions, material studies require dedicated facilities that permit a strict control of the metallic specimen environment throughout the entire exposure. Cea, AREVA-NP and EDF have developed experimental setups respectively under the names CORALLINE and CORINTH, the Chemistry Loop and ESTEREL; these high temperature helium flow systems are fitted with hygrometers and gas analyzers. A benchmarking procedure was defined to inter-validate these lab devices. It is composed of two tests. The joint protocol has set the operating parameters. Process atmospheres are made of helium with 200 {mu}bar H{sub 2}, 20 {mu}bar CH{sub 4}; the CO content reaches 50 {mu}bar for test 1 while it is reduced to 5 {mu}bar CO in test 2. The residual water vapor concentration shall be lower than 3{mu}bar. Corrosion is assessed by mass change associated to observations and analyses of the corroded coupons considering the surface scales (nature, morphology and thickness), the internal oxidation (nature, distribution and depth) and the possible carburization/decarburization (type and depth). For benchmark test 1, Cea, AREVA-NP and EDF produced similar results in terms of operation of the tests as well as about the Inconel 617 corrosion criteria. On the other hand, benchmark test 2 showed a difference in the residual water vapor level between CORALLINE and the Chemistry Loop that was shown to strongly influence the specimen behavior.

  2. The expression of CD147,CEA and their prognostic value in gastric cancer%CD147、CEA 在胃癌组织中的表达及预后价值

    Institute of Scientific and Technical Information of China (English)

    高文华; 付勇; 周萍; 卢宁

    2016-01-01

    目的:研究胃癌组织中 CD147、CEA 的表达及其与胃癌患者临床病理参数和总体生存率之间的关系。方法:应用免疫组织化学(SP)法检测胃癌组织标本及癌旁胃组织中 CD147、CEA 的表达情况,并随访患者进行生存分析。结果:胃癌组织中 CD147、CEA 的阳性表达率均显著高于癌旁组织(P <0.05)。CD147、CEA 在胃癌中的表达均与胃癌的浸润深度、淋巴结转移和 TNM分期显著相关(P <0.05)。相关性分析发现, CD147与 CEA 在胃癌组织中的表达呈正相关(r =0.292,P =0.020)。经 Kaplan -Meier 生存分析显示, CD147、CEA 蛋白表达阳性的患者生存率均明显低于表达阴性组患者(P <0.05)。单因素分析发现肿瘤浸润深度、TNM分期、淋巴结转移、CD147、CEA 均为影响胃癌患者预后的重要因素;Cox 风险模型多因素分析发现肿瘤的 TNM分期、淋巴结转移、CD147、CEA 是影响胃癌预后的独立危险因素。结论:CD147和 CEA 的表达与胃癌的浸润和转移密切相关,两者在胃癌中的表达具有协同作用,它们可协同促进胃癌的侵袭和转移。CD147和 CEA 是胃癌预后的独立危险因素,可成为胃癌预后的新型标志物和治疗的新靶点。%Objective:To study the expressions of CD147 and CEA in gastric cancer and their correlations with clinicopathologic parameters and overall survival rate.Methods:Immunohistochemistry was used to examine the ex-pression of CD147 and CEA in gastric carcinoma and the adjacent normal tissues.All the cases were followed up for survival analysis.Results:The expression rates of CD147,CEA in gastric carcinoma tissues were significantly higher than those in paracancerous normal tissues(P <0.05).The positive expressions of CD147,CEA in gastric cancer tis-sue were significantly correlated to the infiltrative depth,lymphatic metastasis and TNMstage(P <0.05).The survival rates in

  3. Colecta y establecimiento de anonáceas en El Salvador

    OpenAIRE

    Eduardo Cruz; H\\u00E9ctor Deras

    2000-01-01

    El Centro Nacional de Tecnología Agropecuaria y Forestal (CENTA), a través de la Unidad de Recursos Fitogenéticos, inició en 1998 un diagnóstico geográfico de especies de anonáceas, con el objetivo de explorar, recolectar, caracterizar y establecer colecciones de campo en las Estaciones Experimentales. Las características evaluadas para frutos fueron: peso, largo y diámetro, número de semillas, textura de cáscara y pulpa; forma de fruto y cárpelos, daño por plagas y en...

  4. Rosácea, demodex folliculorum y metronidazol tópico

    OpenAIRE

    Castellanos Lorduy, Héctor; Pardo Castro, Gloria

    2011-01-01

    La rosácea fue descrita como entidad probablemente asociada al acné por Unna (I), y se observa más frecuentemente en mujeres de piel clara, aunque una entidad consideraba una variante de ella, el rinofima, como patrimonio casi exclusivo de hombres. Su etiología continua siendo desconocida, aunque existe un consenso entre los investigadores con relación a su probable origen multifactorial. Entre los factores mencionados más frecuentemente se encuentran la predisposición genética, el daño dérmi...

  5. Development of recycled plastic composites for structural applications from CEA plastics

    Science.gov (United States)

    Bhalla, Agrim

    Plastic waste from consumer electronic appliances (CEAs) such as computer and printer parts including Polystyrene (PS), Acrylonitrile Butadiene Styrene (ABS), Polystyrene (PS) and PC/ABS were collected using handheld FTIR Spectrophotometer. The blends of these plastics with High Density Polyethylene (HDPE) are manufactured under special processing conditions in a single screw compounding injection molding machine. The blends are thermoplastics have high stiffness and strength, which may enhance the mechanical properties of HDPE like tensile modulus, ultimate tensile strength, tensile break and tensile yield. These composites have a potential to be used for the future application of recycled plastic lumber, thus replacing the traditional wood lumber.

  6. Diseño del cuestionario "Calidad de entornos abiertos" (CEA)

    OpenAIRE

    2003-01-01

    Novenes Jornades de Foment de la Investigació de la FCHS (Any 2003-2004) El Cuestionario denominado “Calidad de Entornos Abiertos” (CEA) y diseñado por el equipo WONTPrevenció Psicosocial, se enmarca en un proyecto de investigación dirigido al estudio de espacios abiertos como parques o lugares de esparcimiento de Castellón, con el fin de obtener especificaciones de diseño aplicables a la configuración del entorno y productos de uso colectivo en el ámbito urbano, tomando como p...

  7. Changes in soluble CEA and TIMP-1 levels during adjuvant chemotherapy for stage III colon cancer

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Christensen, Ib J; Sölétormos, György;

    2010-01-01

    Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antige...... (CEA) levels in patients with stage III colon cancer.......Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested to be a valuable marker in colorectal cancer (CRC), but the effects of chemotherapy on TIMP-1 levels are unknown. The present study evaluated the effect of chemotherapy on TIMP-1 levels in comparison with carcinoembryonic antigen...

  8. Ocular rosacea: a review Rosácea ocular: revisão

    Directory of Open Access Journals (Sweden)

    Ana Carolina Cabreira Vieira

    2012-10-01

    Full Text Available Rosacea is a prevalent chronic cutaneous disorder with variable presentation and severity. Although considered a skin disease, rosacea may evolve the eyes in 58-72% of the patients, causing eyelid and ocular surface inflammation. About one third of the patients develop potentially sight-threatening corneal involvement. Untreated rosacea may cause varying degrees of ocular morbidity. The importance of early diagnosis and adequate treatment cannot be overemphasized. There is not yet a diagnostic test for rosacea. The diagnosis of ocular rosacea relies on observation of clinical features, which can be challenging in up to 90% of patients in whom accompanying roseatic skin changes may be subtle or inexistent. In this review, we describe the pathophysiologic mechanisms proposed in the literature, clinical features, diagnosis and management of ocular rosacea, as well as discuss the need for a diagnostic test for the disease.A rosácea é uma condição cutânea crônica, que possui apresentações clínicas variáveis. Apesar de considerada uma doença dermatológica, os olhos podem ser acometidos em 58-72% dos casos, causando inflamação palpebral e da superfície ocular. Aproximadamente um terço dos pacientes desenvolve acometimento corneano, podendo causar baixa visual significativa. Diagnóstico precoce e tratamento adequado são de extrema importância, devido à significativa morbidade ocular que a doença pode causar. Não há, até o momento, um teste diagnóstico para rosácea. O diagnóstico da rosácea ocular depende da observação das manifestações clínicas, o que pode ser bastante desafiador em até 90% dos pacientes, em que os achados cutâneos são discretos ou inexistentes. Nesta revisão, descrevemos os mecanismos fisiopatológicos propostos na literatura, manifestações clínicas, diagnóstico e tratamento da rosácea ocular, assim como abordamos a necessidade de um teste diagnóstico.

  9. Intracellular Targeting of CEA Results in Th1-Type Antibody Responses Following Intradermal Genetic Vaccination by a Needle-Free Jet Injection Device

    Directory of Open Access Journals (Sweden)

    Susanne Johansson

    2007-01-01

    Full Text Available The route and method of immunization, as well as the cellular localization of the antigen, can influence the generation of an immune response. In general, intramuscular immunization results in Th1 responses, whereas intradermal delivery of DNA by gene gun immunization often results in more Th2 responses. Here we investigate how altering the cellular localization of the tumor antigen CEA (carcinoembryonic antigen affects the quality and amplitude of DNA vaccine-induced antibody responses in mice following intradermal delivery of DNA by a needle-free jet injection device (Biojector. CEA was expressed either in a membrane-bound form (wild-type CEA or in two truncated forms (CEA6 and CEA66 with cytoplasmic localization, where CEA66 was fused to a promiscuous T-helper epitope from tetanus toxin. Repeated intradermal immunization of BALB/c mice with DNA encoding wild-type CEA produced high antibody titers of a mixed IgG1/IgG2a ratio. In contrast, utilizing the DNA construct that resulted in intracellular targeting of CEA led to a reduced capacity to induce CEA-specific antibodies, but instead induced a Th1-biased immune response.

  10. Inter-comparison of source apportionment models for the estimation of wood burning aerosols during wintertime in an Alpine city (Grenoble, France

    Directory of Open Access Journals (Sweden)

    O. Favez

    2010-01-01

    Full Text Available The emission of organic aerosols (OA in the ambient air by residential wood burning is nowadays a subject of great scientific concern and a growing number of studies aim at apportioning the influence of such emissions on urban air quality. In the present study, results obtained using two commonly-used source apportionment models, i.e., Chemical Mass Balance (CMB, performed with off-line filter measurements and Positive Matrix Factorization (PMF, applied to aerosol mass spectrometer measurements, as well as using the recently-proposed aethalometer model (based on the measurement of the aerosol light absorption at different wavelengths are inter-compared. This work is performed using field data obtained during the winter season (14 to 30 January 2009 at an urban background site of a French Alpine city (Grenoble. Converging results from the different models indicate a major contribution of wood burning organic aerosols (OMwb to the organic fraction, with mean OMwb contributions to total OA of about 67%, 60% and 38% for the CMB, the aethalometer and the AMS-PMF models, respectively. Quantitative discrepancies might notably be due to the overestimation of OMwb calculated by the CMB due to the loss of semi-volatile compounds from sources to receptor site, as well as to the accounting of oxidized primary wood burning organic (OPOAwb aerosols within the Oxygenated Organic Aerosol (OOA PMF-factor. This OOA factor accounts on average for about 50% of total OM, while non-combustion sources contribute to about 25% and 28% of total OM according to the CMB and aethalometer models, respectively. Each model suggests a mean contribution of fossil fuel emissions to total OM of about 10%. A good agreement is also obtained for the source apportionment of elemental carbon (EC by both the CMB and aethalometer models, with fossil fuel emissions representing on average more than 80% of total EC.

  11. Compte-rendu de la journée d'étude de l'ATALA à Grenoble le 22 octobre 2004

    Directory of Open Access Journals (Sweden)

    Lionel Lamadon

    2004-12-01

    Full Text Available La journée d'étude de l'ATALA (Association pour le Traitement Automatique de la Langue s'est déroulée le 22 octobre 2004 à l'université Stendhal Grenoble 3 et avait pour thème : TAL et apprentissage des langues. Cette journée était organisée par le LIDILEM (Laboratoire de Linguistique et Didactique des Langues Étrangères et Maternelles de l'université Stendhal, sous l'égide de l'ATALA et avec le soutien de XRCE (Xerox Research Centre Europe et du projet européen Thetis. Un nombre important de soumissions a permis d'emblée de mesurer l'intérêt suscité par le thème de cette journée. Au final, dix articles ont été sélectionnés pour une présentation orale ainsi que quatre articles pour la session posters. Autour de la thématique générale des liens entre le TAL (Traitement Automatique de la Langue et l'ALAO (Apprentissage des Langues Assisté par Ordinateur, les intervenants ont présenté différents axes de recherche permettant de mieux cerner les enjeux de l'intégration d'outils de TAL dans des environnements informatiques d'aide à l'apprentissage.

  12. Perfil de comercialização das Anonáceas nas Ceasas brasileiras

    Directory of Open Access Journals (Sweden)

    Hélio Satoshi Watanabe

    2014-01-01

    Full Text Available A quantidade de anonáceas comercializadas nas principais centrais de abastecimento está crescendo e concentrada na CEAGESP - 61%. As informações coletadas pelo SIEM da CEAGESP mostram, entre 2011 e 2012, o grande crescimento da oferta de atemoia e de graviola, respectivamente, 35% e 32%, entre 2011 e 2012, e a queda do volume de pinha - 20%, entre 2011 e 2012. A atemoia (54%, a pinha (41% e a graviola (5% são as anonáceas mais importantes comercializadas na CEAGESP. A origem é concentrada nos Estados da Bahia - pinha e graviola, e em Minas Gerais e São Paulo - atemoia. O estudo das causas da diferenciação de valor, entre lotes de atemoia de valores máximo e mínimo, de mesma classificação de tamanho, no mesmo dia, mostrou que a homogeneidade visual de tamanho é a maior responsável pela diferenciação de valor. A melhoria da seleção por tamanho é a melhor estratégia de diferenciação de valor a ser adotada pelo produtor.

  13. Aeroacoustics research in Europe: The CEAS-ASC report on 2014 highlights

    Science.gov (United States)

    Detandt, Yves

    2015-11-01

    The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. Each year the committee highlights some of the research and development projects in Europe. This paper is the 2014 issue of this collection of Aeroacoustic Highlights, compiled from informations submitted to the CEAS-ASC. The contributions are classified in different topics; the first categories being related to specific aeroacoustic challenges (airframe noise, fan and jet noise, helicopter noise, aircraft interior noise) and two last sections are respectively devoted to recent improvements and emerging techniques and to general advances in aeroacoustics. For each section, the present paper focus on accomplished projects, providing the state of the art in each research category in 2014. A number of research programmes involving aeroacoustics were funded by the European Commission. Some of the highlights from these programmes are summarised in this paper, as well as highlights funded by national programmes or by industry.

  14. Marcha de absorção de nutrientes em anonáceas

    Directory of Open Access Journals (Sweden)

    Abel Rebouças São José

    2014-01-01

    Full Text Available A nutrição mineral está relacionada com a fisiologia do crescimento e da reprodução das anonáceas, pois cada espécie do gênero Annona possui sua carga genética que apresenta requerimentos nutricionais específicos para suas funções metabólicas. A marcha de absorção de nutrientes é muito importante para definir os estádios de desenvolvimentos e as doses adequadas de aplicação de fertilizantes nas anonáceas e obter delas seu máximo potencial produtivo. Há poucos estudos científicos a respeito de nutrição e da adubação de plantas dessa família botânica, mas é sabido que são muito exigentes em nutrientes. No presente trabalho, são abordadas as principais exigências minerais dentro do gênero Annona, com ênfase para pinha (A. squamosa e graviola (A. muricata, que afetam o crescimento vegetativo e reprodutivo, bem como a qualidade dos frutos (teor de açucares, acidez, firmeza e rachadura de frutos, etc.. A marcha de absorção em gravioleira, na fase de crescimento de mudas, é de forma decrescente: K>N>Ca>Mg>P e Fe>Zn>Mn>Cu. Expressivas quantidade de N, K, Ca, P e Mg são extraídas pelas anonáceas em comparação com outras frutíferas. A exportação de macronutrientes pelos frutos de pinha (A. squamosa é superior aos exportados por laranjas, abacaxi, abacate e muitas outras frutas. A marcha de absorção de nutrientes dá-se de formas diferentes entre as anonáceas. Em relação aos micronutrientes, é sabido que o B e Zn desempenham importante função fisiológica no crescimento e na reprodução dessas plantas, mas a depender das características físicas e químicas do solo, outros elementos, como Fe, Mo, Cu, etc., poderão ser restritivos ao desenvolvimento e à produção dessa família de plantas. A crescente importância nos mercados de consumo in natura e de processamento industrial exige investigações científicas sobre a marcha de absorção e de nutrição mineral para as diversas espécies de anonáceas.

  15. Different Levels of CEA, CA153 and CA125 in Milk and Benign and Malignant Nipple Discharge.

    Directory of Open Access Journals (Sweden)

    Song Zhao

    Full Text Available The aim of this study was to assess the diagnostic values of three breast tumor markers (i.e., CEA, CA153 and CA125 in milk and nipple discharge in the prediction of different breast diseases diagnoses.Three hundred thirty-six patients (96 breast cancer and 240 benign disease patients with nipple discharge and a control group of 56 healthy parturient participants were enrolled in the present study. Nipple discharge samples were preoperatively collected from the patients, and milk was collected from the colostrum of the parturient participants. The samples were assayed for the CEA, CA153 and CA125 levels. Cutoff values were determined for the detection of breast diseases using ROC curves.The levels of CEA, CA153 and CA125 were significantly different between the nipple discharge and the milk (all ps < 0.001. In the nipple discharge, the CEA and CA153 levels in the breast cancer group were significantly greater than those in the benign group (all ps < 0.001, and cutoff values of 263.3 ng/mL and 1235.3 U/mL, respectively, were established. However, the expression of CA125 did not differ significantly between the breast cancer and benign groups.Differences in the apparent expression levels of CEA, CA153 and CA125 in patients with nipple discharge and healthy persons were validated. The present data suggest that CEA and CA153 might potentially be useful in the differential diagnoses of benign tumors and breast cancer. CA125 did not seem to be useful for breast cancer detection.

  16. Efficacy of 18F-FDG PET/CT in investigation of elevated CEA without known primary malignancy

    Directory of Open Access Journals (Sweden)

    Simon Sin-man Wong

    2016-01-01

    Full Text Available Aim: To evaluate the efficacy of 18flurodeoxyglucose positron emission tomography/computer tomography (18F-FDG PET/CT in investigating patients with elevated carcinoembryonic antigen (CEA and without known primary malignancy, and the impact of PET/CT findings on patient management. Setting and Design: PET/CT scans done in a tertiary hospital between December 2007 and February 2012 for elevated CEA in patients without known primary malignancy were retrospectively reviewed. Materials and Methods: The PET/CT findings, patients' clinical information, level of CEA, histological diagnosis, and subsequent management were retrieved by the electronic patient record for analysis. Statistical Analysis: Data were analyzed using SPSS version 19. Results: One hundred and one PET/CT scans were performed for patients with elevated CEA. Fifty-eight of these were performed for patients with known primary malignancy and were excluded; 43 PET/CT scans were performed for patients without known primary malignancy and were included. Thirty-three (77% had a positive PET/CT. Among the 32 patients with malignancy, 15 (47% suffered from lung cancer and 8 (25% suffered from colorectal cancer. The sensitivity (97%, specificity (82%, positive predictive value (94%, negative predictive value (90%, and accuracy (93% were calculated. Thirty (91% patients had resultant change in management. The mean CEA level for patients with malignancy (46.1 ng/ml was significantly higher than those without malignancy (3.82 ng/ml (P < 0.05. In predicting the presence of malignancy, a CEA cutoff at 7.55 ng/ml will achieve a sensitivity of 91% and a specificity of 73%. Conclusion: PET/CT, in our study population, appears to be sensitive, specific, and accurate in investigating patients with elevated CEA and without known primary malignancy. In addition to diagnosis of underlying primary malignancy, PET/CT also reveals occult metastases which would affect patient treatment options.Its role in

  17. Clinical Significance of CK20, CK19, CEA mRNAs in Peripheral Blood from Lung Cancer Patients

    Directory of Open Access Journals (Sweden)

    Ying GUO

    2009-09-01

    Full Text Available Background and objective The tumor cells may disseminate into circulation even in early stages. However, the numbers of such cells are so small that they cannot be detected by conventional diagnostic methods. Developments in molecular technology have made it possible to detect small numbers of tumor cells in peripheral blood. In this study, 83 preoperative peripheral blood samples from patients with lung cancer were analyzed for the determination of CEA, CK19, and CK20 mRNA expression in peripheral blood, and its clinical significance was evaluated. Methods Nested reverse transcriptasepolymerase chain reaction (nested RT-PCR was used to analyze CEA, CK19, and CK20 mRNA expression in peripheral blood. Fresh tumor tissues from patients with esophageal cancer (n=15 were used as a positive control, and blood samples from 15 healthy volunteers as a negative control. Results Among 83 blood samples from patients with lung cancer, the expression of CK20, CK19 and CEA mRNA was 41.0%, 36.1% and 48.2%, respectively. 73.5% were positive for at least one markers for these three genes, and were significantly correlated with the metastasis of the cancer (P < 0.05, but had no correlation with age and sex. In primary esophageal tumors, 15 tumor tissues were all positive for CEA, CK19, and CK20 mRNA. 2 of 15 blood samples from healthy donors were positive for CK19 and CEA mRNA, and 1 of 15 blood sample positive for CK20 mRNA. Conclusion The three markers of CK20, CK19 and CEA mRNA could be the target genes in detecting circulating tumor cells in peripheral blood from patients with lung cancer. The combined detection of CK20, CK19 and CEA mRNA by RT-PCR assay may contribute to the PCR positivity and sensitivity, and CK20, CK19, CEA mRNA expression increase the specificity.

  18. Search for CEA-like molecules in polymorphonuclear leukocytes of non-human primates using monoclonal antibodies.

    Science.gov (United States)

    Jantscheff, P; Indzhiia, L V; Micheel, B

    1986-01-01

    The monoclonal anti-CEA antibody ZIK-A42-A/C1 which reacts with NCA of human polymorphonuclear leukocytes was found to bind also to polymorphonuclear blood leukocytes of the following non-human primates tested: hamadryas baboon (Papio hamadryas), stump-tailed monkey (Macaca arctoides), pig-tailed monkey (Macaca nemestrina), and rhesus monkey (Macaca mulata). No binding was observed to mononuclear blood leukocytes. It was concluded that non-human primates contain CEA-like substances in their polymorphonuclear leukocytes as humans do and that these substances carry some identical epitopes.

  19. Big Data solution for CTBT monitoring: CEA-IDC joint global cross correlation project

    Science.gov (United States)

    Bobrov, Dmitry; Bell, Randy; Brachet, Nicolas; Gaillard, Pierre; Kitov, Ivan; Rozhkov, Mikhail

    2014-05-01

    Waveform cross-correlation when applied to historical datasets of seismic records provides dramatic improvements in detection, location, and magnitude estimation of natural and manmade seismic events. With correlation techniques, the amplitude threshold of signal detection can be reduced globally by a factor of 2 to 3 relative to currently standard beamforming and STA/LTA detector. The gain in sensitivity corresponds to a body wave magnitude reduction by 0.3 to 0.4 units and doubles the number of events meeting high quality requirements (e.g. detected by three and more seismic stations of the International Monitoring System (IMS). This gain is crucial for seismic monitoring under the Comprehensive Nuclear-Test-Ban Treaty. The International Data Centre (IDC) dataset includes more than 450,000 seismic events, tens of millions of raw detections and continuous seismic data from the primary IMS stations since 2000. This high-quality dataset is a natural candidate for an extensive cross correlation study and the basis of further enhancements in monitoring capabilities. Without this historical dataset recorded by the permanent IMS Seismic Network any improvements would not be feasible. However, due to the mismatch between the volume of data and the performance of the standard Information Technology infrastructure, it becomes impossible to process all the data within tolerable elapsed time. To tackle this problem known as "BigData", the CEA/DASE is part of the French project "DataScale". One objective is to reanalyze 10 years of waveform data from the IMS network with the cross-correlation technique thanks to a dedicated High Performance Computer (HPC) infrastructure operated by the Centre de Calcul Recherche et Technologie (CCRT) at the CEA of Bruyères-le-Châtel. Within 2 years we are planning to enhance detection and phase association algorithms (also using machine learning and automatic classification) and process about 30 terabytes of data provided by the IDC to

  20. A produção de anonáceas no Brasil

    Directory of Open Access Journals (Sweden)

    Eurico Eduardo Pinto de Lemos

    2014-01-01

    Full Text Available As anonáceas compõem um grupo de plantas que se têm destacado em várias partes do mundo, principalmente por produzirem frutos de grande interesse comercial. Entre os mais destacados membros desta família, estão a cherimólia (Annona cherimola, a pinha (A. squamosa, a atemoia (híbrido A. squamosa x A. cherimola, e a graviola (A. muricata. No Brasil, pelas suas características de clima tropical e com baixas altitudes na maior parte de seu território, a cherimólia tem sido pouco cultivada devido a sua exigência em temperaturas baixas. As demais apresentam áreas cultivadas em diversas regiões do País para fazer frente à demanda dos mercados de frutas frescas (pinha e atemoia e processadas (graviola. Todavia, o interesse neste grupo de plantas é mais abrangente, tendo em vista que inúmeras pesquisas comprovam que compostos secundários obtidos de várias anonáceas possuem atividade pesticida e antitumoral. Este trabalho objetiva apresentar um quadro atual da produção de anonáceas no Brasil, focando nas principais anonas cultivadas nas diferentes regiões do País. Para tanto, foram levantados dados de produção e principais tecnologias utilizadas nestas culturas. Os dados de produção obtidos serviram para estabelecer uma estimativa aproximada da realidade da produção de atemoia, pinha e graviola no Brasil. Os resultados demonstram um vigoroso crescimento na área total de cultivo, na produção e no uso de tecnologias modernas para as três espécies consideradas neste estudo. Apontam também para uma expansão dos cultivos em todas as regiões do Brasil, principalmente no Nordeste.

  1. KROTOS FCI experimental programme at CEA Cadarache: new features and status

    Energy Technology Data Exchange (ETDEWEB)

    Bonnet, J.M.; Bullado, Y.; Journeau, C.; Fouquart, P.; Piluso, P.; Sergeant, C.; Magallon, D. [CEA-Cadarache, DTN/STRI/LMA, Bat 708, BP1, 13108 Saint Paul lez Durance cedex (France)

    2005-07-01

    Full text of publication follows: KROTOS facility has been operated by the European Commission at JRC-Ispra for many years until 1999 as part of the FARO/KROTOS programme. The programme had to be stopped at JRC due to new EC priorities, and an agreement was concluded with CEA to transfer the KROTOS facility and know-how to Cadarache to continue investigating the pending FCI issues. By this agreement, CEA became owner of the facility. The main objective of the KROTOS programme at CEA Cadarache is understanding the role of melt properties in steam explosion propagation and energetics and, in particular, steam explosion behaviour of prototypical corium melts. Possible influence of physicochemical processes on explosiveness will also be explored. Actually, analysis of alumina debris produced at Ispra have shown that formation of metastable phases and chemical reaction with water at high temperature may play a significant role in enhancing heat transfer to water in the explosion phase. In order to reach the objective, steam explosion experiments are performed in well characterised conditions for a large spectrum of conditions and melt compositions of interest for both in- and ex-vessel situations. A trigger is applied as a rule. Advanced technology and instrumentation is used to reduce uncertainties on initial conditions and characterise the various phases of an explosion, with emphasis on high energy X-ray cinematography to qualify pre-mixing. This advanced instrumentation will enable the measurement of detailed variables to consolidate the qualification of the FCI codes. The use of high energy X-rays made it necessary to construct a new building to house the facility and its components. The facility should newly become operative early 2005. Main improvements with respect to Ispra concern melt delivery, hydrogen measurement and X-ray imaging. Preliminary studies have demonstrated that identification of the pre-mixture-water interface and coherent melt jet core, and

  2. Estaquia caulinar herbácea e semilenhosa de Drimys brasiliensis1

    Directory of Open Access Journals (Sweden)

    Luciele Milani Zem

    Full Text Available Drimys brasiliensis conhecida como cataia, é uma espécie arbórea nativa da Mata Atlântica. Tem importância fitoquímica, fitoterapêutica, aromática e econômica, utilizada na fabricação de licores, condimentos, dentre outros. É considerada uma espécie de difícil multiplicação via sementes, apresentando dormência por imaturidade embrionária. Assim, objetivou-se estudar a propagação vegetativa por meio da indução do enraizamento de estacas herbáceas e semilenhosas submetidas a diferentes concentrações de ácido indolbutírico (IBA, coletadas em duas épocas do ano (junho/2011 e dezembro/2011. Foram utilizados os tratamentos: testemunha (100% água, 0 (50% água e 50% álcool; 1.500; 3.000 e 6.000 mg L-1IBA (em solução hidroalcoólica 50% para o inverno e, no verão, os mesmos tratamentos, exceto 0 mg L-1IBA. Foi conduzido um experimento em delineamento inteiramente casualizado, em esquema fatorial de 5 concentrações x 2 tipos de estacas em junho/2011; e outro experimento com 4 concentrações x 2 épocas de coleta (estacas de junho/2011 e estacas de dezembro/2011 Após 120 dias em casa de vegetação, avaliou-se a porcentagem de estacas enraizadas, número de raízes/estaca, comprimento médio de raízes/estaca, porcentagem estacas vivas, com calos, mortas, com novas brotações e que mantiveram as folhas iniciais. A aplicação de IBA não influenciou nenhuma das variáveis estudadas. Estacas herbáceas apresentaram melhor enraizamento (46,75% quando comparadas às semilenhosas (34,44%. A coleta realizada em dezembro/2011 apresentou maior número de raízes/estaca (5,47 porém maior mortalidade (29,05% que em junho/2011 (4,25 e 12,19%, respectivamente. Sendo assim, para o enraizamento de cataia é indicada a utilização de estacas caulinares herbáceas, coletadas em épocas frias.

  3. On 28 April, CERN welcomed Jean-Claude Petit, director of programmes of the Commissariat á l'Energie Atomique (CEA) in France, and Olivier Pagezy, finance director of the CEA.

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    They visited the assembly hall for the CMS experiment, the COMPASS experiment and the test facilities for the LHC magnets. They are pictured (no 01) in the ATLAS cavern with Peter Jenni, ATLAS spokesman, and Gabriele Fioni, CEA deputy director of programmes

  4. Assessment of lichen diversity by index of atmospheric purity (IAP), index of human impact (IHI) and other environmental factors in an urban area (Grenoble, southeast France).

    Science.gov (United States)

    Gombert, S; Asta, J; Seaward, M R D

    2004-05-25

    An assessment of air quality in the Grenoble area was made using the index of atmospheric purity (IAP). The survey area was divided into 198 units (0.7 x 1 km), in which 345 average lichen relevés were analyzed according to the Braun-Blanquet method. Each relevé station was characterized in the field by a subjective index of human impact (IHI) calculated according to four local environmental parameters influencing the epiphytic lichen flora: urbanization (urban, suburban or rural area), road traffic (low or high), local developments (stations located within crop fields, green areas, housing sites or car parks), and exposure (trees isolated, in rows or grouped). Eighty-three epiphytic lichen species and two algae were recorded and grouped into three ecological categories defined according to bark type and nutrient needs: nitrophytic, neutrophytic and acidophytic species. IAP values, varying from 5.9 to 71.7, were clustered into five categories in order to produce an air-quality map. The geographical pattern of the IAP map showed no clear connection with local sources of pollution, such as the vicinity of a road or an industrial plant, and was not correlated with annual mean values of SO(2), NO(2) and NO for the years 1994-1997. IAP appeared to be influenced by environmental artificiality as shown by a polynomial trend observed between IAP and IHI, even if IAP values were broadly scattered. Multivariate analysis (canonical correspondence) showed that high IAP values could be observed in stations of "natural" environments at high elevations and in stations of "artificial" environments at low elevations. It was also shown that IAP varied in relation to the relative proportion of ecological groups of lichen relevés: although a majority of neutrophytic species (>50%) with a much lower percentage of nitrophytic species generally characterized high IAP, a predominance of acidophytic or nitrophytic species led to a decrease in the IAP. A correlation between nitrophytic

  5. Cea-DSM-DAPNIA-SACM contribution to IFMIF KEP phase June 2000 to December 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-05-01

    The international fusion materials irradiation facility (IFMIF) requires the generation by a linear accelerator (LINAC) of 250 mA continuous current of deuterons at a nominal energy of 40 MeV. The basic approach is to provide 2 linac modules, each delivering 125 mA to a common target. The accelerators begin with a deuteron ion source and a low-energy beam transport to a radio-frequency quadrupole (RFQ), a buncher and a pre-accelerator up to 5 MeV. The key element technology phase (KEP) was initiated in 2000 with the objective of reducing some key technology risk factors. The IFMIF KEP is carried out at the Cea and it focuses on 5 issues: the ECR source, the 4-vanes RFQ design, the radio-frequency system, the DTL (drift tube linac) design, and high power diagnostics. The present report reviews progress made in the 5 issues quoted above. (A.C.)

  6. Escala de Afrontamiento del Estrés Académico (A-CEA.

    Directory of Open Access Journals (Sweden)

    Isabel Piñeiro

    2010-01-01

    Full Text Available Assuming that the effects of stressors on students´ health, cognitive functioning and wellbeing depends on the stressors and how these are addressed, this paper attempts to prove the validity of an instrument for the specific evaluation of the coping stress strategies of university students. This work is developed in two phases. For this purpose a bank of items bringing together different coping stress strategies were elaborated and a application with a sample of university students was carried out. Results of this study suggest that the coping scale of academic stress questionnaire (Escala de Afrontamiento del Cuestionario de Estrés académico, A-CEA, that allows to differentiate between social support, cognitive reappraisal and planning, can be a useful instrument in the university scope.

  7. Microflora de Bromeliáceas do estado de Pernambuco, Brasil

    Directory of Open Access Journals (Sweden)

    Luis Tavares de Lyra

    1976-01-01

    Full Text Available O autor estudou a microflora de dois gêneros de BROMELIACEAE: Hoenbergia e Portea. As coletas do material foram feitas em seis regiões do Estado de Pernambuco; 1 Região da Mata-Úmida; 2 Região da Mata-Seca; 3 Região do Agreste Central; 4 Região do Agreste Setentrional; 5 Região do Agreste Meridional; 6 Região do Recife. As seguintes diatomáceas indicadoras de águas poluídas (espécies oligossaprobias foram encontradas nas seis regiões estudadas: Gomphonema parvulum (Kutz Grunow., Hantzschia amphioxys Grunow, Pinnularia borealis Ehr., Pinnularia microstauron (Ehr Cleve, gomphonema gracile Ehr., Nitzschia palea Kutz., Melosira roeseana Rabenh., Navicula mutica Kutz., Navicula cryptocephala Kutz., Eunotia pectinalis (Kutz Rabenh. Foram também observadas CHLOROPHYCEAS nas estações chuvosa e seca nas diversas regiões. Algumas são indicadoras de oligossaprobidade: Scenedesmus quadricauda (Turpin brebisson. Chlorococcum sp., Chlorella sp. Os fatores ecológicos e comentários referentes ás diatomáceas foram anotados no texto. A tabela I indica a frequência das diatomáceas nas seis regiões estudadas. Maior número dessas diatomáceas, registramos nas regiões do Agreste. A tabela II mostra a temperatura e pH da água de Hoenbergia e Portea em ambas as estações do ano (inverno e verão. Observamos a ocorrência de larvas de culex em Portea e hoenbergia, entretanto, raramente encontramos larvas de Anopheles. As coletas foram feitas durante as estações chuvosa e seca em Hoenbergia e Portea. Determinamos 35 espécies provenientes de 78 amostras coletadas durante o período de 26 meses.The author studied the microflora from two genera of Bromeliaceae: Hoenbergia and Portea. The material was collected in six natural regions of Pernambuco State: 1 Humid Forest Region; 2 Dry forest region; 3 Central Agreste Region; 4 Setentrional Agreste Region; 5 Meridional Agreste Region; 6 Recife Region. The following diatoms that indicate polluted

  8. Spin-off from Euratom-CEA association in fusion magnetic research

    Energy Technology Data Exchange (ETDEWEB)

    Rey, Guy E-mail: guy.rey@cea.fr; Magaud, P.; Libeyre, P.; Garin, P.; Agarici, G.; Beaumont, B.; Berger-by, G.; Bibet, P.; Chappuis, P.; Cordier, J.J.; Couturier, B.; Duchateau, J.L.; Durocher, A.; Escourbiac, F.; Gravil, B.; Kazarian, F.; Lipa, M.; Magne, R.; Portafaix, C.; Schlosser, J

    2003-09-01

    Significant spin-off from magnetic fusion research in Euratom-CEA association, over the last 40 years, has been induced and developed through a continuous process of exchange of scientific, technology and managerial expertise between the fusion scientists and manufacturing engineers. The growth in shared expertise, associated innovative applications and cooperative efforts with industry can be clearly identified (i) in the frame of the European Fusion Development Agreement (EFDA) and underlying technology programme, (ii) by the industrial applications induced from Tore Supra programme and the associated joint development of large test bed facilities for control and acceptance test, (iii) by the appreciation of the expected impacts of ITER from the companies involved in the Tore Supra construction.

  9. GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)

    CERN Document Server

    Schapira, J P

    1999-01-01

    Nuclear waste partitioning and transmutation (P and T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON (GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented.

  10. Meeting of Directors and Heads of Department from CEA-Saclay, France

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Directors and Heads of Department from the Saclay centre of the French atomic energy commission (CEA) visited CERN in December. Here, on a tour of CERN's LHC magnet test facility, LHC division leader Philippe Lebrun (right foreground) explains to visitors the construction and function of an LHC superconducting dipole magnet. Photo 01: Left to right: M. Roche, G. Carolla, M. Lequien, J.Y. Guillamot, B. Mercier, Y. Bourlat, J.-P. Pervès, D. Moulin, A. Masurel, Ph. Lebrun, and X. Vitart. Photo 03: Left to right: G. Carolla, M. Lequien, J.Y. Guillamot, M. Pierrey. B. Mercier, J.-P. Pervès, D. Moulin, A. Masurel, and Ph. Lebrun.

  11. Meeting of Directors and Heads of Department from CEA-Saclay, France

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Directors and Heads of Department from the Saclay centre of the French atomic energy commission (CEA) visited CERN in December. Here, on a tour of CERN's LHC magnet test facility, LHC division leader Philippe Lebrun (right) explains to visitors the myriad connections of an LHC superconducting dipole magnet. Photo 01: Left to right: J.Y. Gascoin, J. Feltesse, J.-P. Pervès, and Ph. Lebrun. Photo 02: Left to right: L. Laurent, B. Mercier, M. Lieven, B. Mansoulié, M. Pallier, M. Roche, G. Carola, J.Y. Gascoin, A. Masurel, X. Vitart, F. Kircher, J. Feltesse, J.-P. Pervès, and H. Barbelin. Photo 03: Left to right: Ph. Pallier, M. Roche, P. Laurent, J.-Y. Gascoin, G. Carola, A. Masurel, J. Feltesse, J.-P. Pervès, H. Barbelin, and Ph. Lebrun.

  12. Las Podocarpáceas de los bosques montanos del noroccidente peruano

    Directory of Open Access Journals (Sweden)

    Edgar E. Vicuña-Miñano

    2013-05-01

    Full Text Available Los bosques montanos del noroccidente peruano son formaciones vegetales que presentan una alta diversidad y endemismos. Lamentablemente, en muchos lugares están sujetos a procesos acelerados de deterioro por la deforestación y colonización, aspecto que los convierte en uno de los ecosistemas más amenazados por el hombre. Lo que ahora queda de estos bosques, alguna vez extensos, son sólo fragmentos. Los bosques montanos relictos son ecosistemas ubicados por encima de los 1000 m de altitud, en la Vertiente Occidental de los Andes. Es en estos bosques, donde se pueden encontrar especies de coníferas nativas de nuestro país, pertenecientes a la familia Podocarpaceae. Estas especies juegan un rol de suma importancia en la dinámica de estos ecosistemas tan frágiles; no obstante, debido a la calidad de sus maderas, están siendo extraídas de manera alarmante. En el noroccidente peruano existen zonas de bosques homogéneos de Podocarpáceas tal es el caso del bosque de Cachil en la provincia de Contumazá, bosque de TongodQuellahorco en la provincia de San Miguel (en los cuales predomina la especie Podocarpus oleifolius y los bosques de San Ignacio en Cajamarca, en los que reportamos cinco especies de Podocarpáceas distribuidas en tres géneros: Podocarpus (P. oleifolius, P. macrostachys, P sprucei, Prumnopitys (P. harmsiana y Nageia (N. rospigliosii, las cuales representan el 50% del total de especies reportadas para el Perú.

  13. Colecta y establecimiento de anonáceas en El Salvador

    Directory of Open Access Journals (Sweden)

    Eduardo Cruz

    2000-01-01

    Full Text Available El Centro Nacional de Tecnología Agropecuaria y Forestal (CENTA, a través de la Unidad de Recursos Fitogenéticos, inició en 1998 un diagnóstico geográfico de especies de anonáceas, con el objetivo de explorar, recolectar, caracterizar y establecer colecciones de campo en las Estaciones Experimentales. Las características evaluadas para frutos fueron: peso, largo y diámetro, número de semillas, textura de cáscara y pulpa; forma de fruto y cárpelos, daño por plagas y enfermedades y un análisis bromatológico. Como resultado de este trabajo se estableció la colección de anonáceas con las siguientes especies: squamosa, cherimola, reticulata, muricata, purpurea, diversifolia, holosericea y glabra. En la caracterización morfológica preliminar Annona muricata obtuvo un promedio de 175 semillas/fruto y 1,319 g en peso del fruto. A. cherimola con pulpa muy arenosa y carpelos no prominentes. A. squamosa con pulpa dulce, blanca y cárpelos muy prominentes. De la caracterización bromatológica se determinó que Annona muricata dio contenidos de humedad superiores a 82,8%; fibra cruda de 1,84% y fósforo con 367 ppm. En Annona diversifolia con menor grasa 0,01%. La mayor incidencia por plagas en frutos y semillas fue causado por el perforador Bephrateloides sp. La antracnosis (Colletotrichum sp. en frutos y follaje fue la enfermedad más observada

  14. Gnatophyma: a rare form of rosacea Gnatofima: uma forma rara de rosácea

    Directory of Open Access Journals (Sweden)

    Ana Carolina Lisboa de Macedo

    2012-12-01

    Full Text Available Phyma is the last stage of rosacea and is due to chronic inflammation and edema. It can affect nose (rhinophyma, chin (gnatophyma, forehead (metophyma, ears (otophyma and eyelids (blepharophyma. Rhinophyma is the most frequent location and there are few reports about gnatophyma. We report the case of a female patient, 41 years old, who had an infiltrated, erythematous, edematous plaque around the chin and lower lip for two years. Histopathology showed perivascular lymphocytic infiltrate, hypertrophied follicles and sebaceous glands, dilated vessels and fibrosis. She was treated with oral tetracycline, oral ivermectin and metronidazole cream with a satisfactory response. The clinical, histopathological and therapeutic response correlation confirmed the diagnosis of gnatophyma, a rare variant of phyma.Fima é o estágio final da rosácea e ocorre devido ao edema e inflamação crônica. Pode acometer nariz (rinofima, mento (gnatofima, fronte (metofima, orelhas (otofima e pálpebras (blefarofima. Rinofima é a localização mais encontrada e há raros relatos de gnatofima. Relataremos paciente feminina, 41 anos, que apresentava placa infiltrada, eritêmato-edematosa, em todo o mento e lábio inferior há dois anos. Histopatológico com infiltrado linfocitário perianexial e perivascular, folículos e glândulas sebáceas hipertrofiadas, vasos ectasiados e fibrose perianexial. Foi instituído tratamento com tetraciclina via oral, ivermectina via oral e metronidazol creme com resposta satisfatória. Através da correlação clínica, histopatológica e resposta terapêutica confirmou-se o diagnóstico da variante rara de fima, gnatofima.

  15. Levels of CEA, CA153, CA199, CA724 and AFP in nipple discharge of breast cancer patients.

    Science.gov (United States)

    Zhao, Song; Mei, Yu; Wang, Yongmei; Zhu, Jiang; Zheng, Guixi; Ma, Rong

    2015-01-01

    The distinction between breast cancer and benign breast diseases with nipple discharge remains an important diagnostic challenge. The purpose of this study was to predict the potential usefulness of tumor markers in nipple discharge and to investigate the relationship of tumor markers and clinical characteristics with breast cancer.One hundred and eleven patients with nipple discharge received breast surgery from November 2013 to December 2014 were included in the study. We evaluated levels of five tumor markers (CEA, CA153, CA199, CA724 and AFP) prior to treatment. Patients were divided into two groups according to postoperative pathological results: 30 cases in breast cancer group and 81 cases in benign group. The relationships of clinical characteristics with breast cancer were investigated by multivariate analysis with a logistic regression model.It showed significant differences in levels of nipple discharge CEA (P AFP (P = 0.834) among two groups. Logistic regression analysis demonstrated complaint, age, menopause, abnormal palpable mass, CEA and CA153 were associated with breast cancer. In summary, measurements of CA199, CA724 and AFP in nipple discharge are not of great clinical value. Detecting CEA and CA153 in nipple dischargecould potentially be used for the early detection of breast cancer with in high-risk populations.

  16. Prognostic value of serum CYFRA21-1 and CEA for non-small-cell lung cancer.

    Science.gov (United States)

    Zhang, Zhi-Hui; Han, Yun-Wei; Liang, Hui; Wang, Le-Min

    2015-11-01

    The aim of the study was to assess the clinical prognostic value of serum cytokeratin 19 fragment (CYFRA21-1) and carcinoembryonic antigen (CEA) for non-small-cell lung cancer (NSCLC) patients. Literatures related to effects of serum CYFRA21-1 and CEA on the prognosis of lung cancer patients were retrieved from databases such as PubMed, Springer Link, Embase, Wanfang, and CNKI. Meta-analysis was carried out using RevMan 5.1 software. Ten literatures involving 1990 NSCLC patients were selected in this study. Total survive estimation merging hazard ratio (HR) in all NSCLC patients with high-level serum CYFRA21-1 was 1.64 (95% CI 1.46-1.84, P < 0.001) and that in all NSCLC patients with high level serum CEA was 1.46 (95% CI 1.28-1.65, P < 0.001). Serum CYFRA21-1 and CEA can be used as prognostic factors of NSCLC patients. Combinative detection of the two indices will be more reliable.

  17. Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer

    DEFF Research Database (Denmark)

    Aldulaymi, Bahir; Christensen, Ib J; Sölétormos, György

    2010-01-01

    Preoperative biomarkers serum CEA and plasma TIMP-1 have been shown to have prognostic and predictive value in patients with colorectal cancer. The aim of the present study was to evaluate the possible impact of chemoradiotherapy (CRT) on preoperative biomarker levels in patients with rectal cancer....

  18. A combination of preoperative CT findings and postoperative serum CEA levels improves recurrence prediction for stage I lung adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Yamazaki, Motohiko, E-mail: xackey2001@gmail.com [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Ishikawa, Hiroyuki [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Kunii, Ryosuke [Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Tasaki, Akiko; Sato, Suguru; Ikeda, Yohei; Yoshimura, Norihiko [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan); Hashimoto, Takehisa; Tsuchida, Masanori [Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences (Japan); Aoyama, Hidefumi [Department of Radiology, Niigata University Graduate School of Medical and Dental Sciences (Japan)

    2015-01-15

    Objectives: To assess the prognostic value of combined evaluation of preoperative CT findings and pre/postoperative serum carcinoembryonic antigen (CEA) levels for pathological stage I lung adenocarcinoma. Methods: This retrospective study included 250 consecutive patients who underwent complete resection for ≤3-cm pathological stage I (T1–2aN0M0) adenocarcinomas (132 men, 118 women; mean age, 67.8 years). Radiologists evaluated following CT findings: maximum tumor diameter, percentage of solid component (%solid), air bronchogram, spiculation, adjacency of bullae or interstitial pneumonia (IP) around the tumor, notch, and pleural indent. These CT findings, pre/postoperative CEA levels, age, gender, and Brinkman index were assessed by Cox proportional hazards model to determine the best prognostic model. Prognostic accuracy was examined using the area under the receiver operating characteristic curve (AUC). Results: Median follow-up period was 73.2 months. In multivariate analysis, high %solid, adjacency of bullae or IP around the tumor, and high postoperative CEA levels comprised the best combination for predicting recurrence (P < 0.05). A combination of these three findings had a greater accuracy in predicting 5-year disease-free survival than did %solid alone (AUC = 0.853 versus 0.792; P = 0.023), with a sensitivity of 85.7% and a specificity of 74.3% at the optimal threshold. The best cut-off values of %solid and postoperative CEA levels for predicting high-risk patients were ≥48% and ≥3.7 ng/mL, respectively. Conclusion: Compared to %solid alone, combined evaluation of %solid, adjacency of bullae or IP change around the tumor, and postoperative CEA levels improves recurrence prediction for stage I lung adenocarcinoma.

  19. 某地区健康体检人群血清 AFP、CEA 血清水平的调查%Investigation on serum AFP and CEA levels in healthy physical examination people in save area

    Institute of Scientific and Technical Information of China (English)

    郝娟; 张邑雨; 侯会香; 赵俊红; 段雄波; 李金钟

    2014-01-01

    目的:调查本地区健康体检人群血清 AFP、CEA 水平以及性别差异。方法(1)将健康体检人群按性别分为 A 组(男510例)和 B 组(女477例),(2)分别将 A 组和 B 组按年龄段分成:A1组(<40岁)、A2组(40~<50岁)、A3组(50~<60岁)、A4组(60~<70岁)、A5组(70~87岁)和 B1组(<40岁)、B2组(40~<50岁)、B3组(50~<60岁)、B4组(60~<70岁)、B5组(70~87岁),采用电化学发光免疫分析技术对987例健康体检人员的血清 AFP、CEA 进行检测,将 A 组和 B 组比较看有无统计学差异;A 组各组间比较看有无统计学差异,B 组各组间比较看有无统计学差异。结果(1)A 组和 B 组比较,AFP 和 CEA结果差异有统计学意义(P <0.01);(2)A 组各亚组间比较 AFP 和 CEA 均无差异;B 组各亚组间比较 AFP 和 CEA 均无差异。结论本地区健康体检人群男女之间 AFP 和 CEA 血清含量有差异,且男性 AFP 和 CEA 血清含量明显高于女性,提示应该按性别分别建立 AFP 和 CEA 的参考范围;而 AFP 和 CEA 的血清含量在男女各年龄组间均无差异。%Objective To investigate the levels of serum AFP and CEA in healthy physical examination people and their sexual difference.Methods (1 )Healthy physical examination people were divided into the group A(510 males)and group B(477 fe-males);(2)these two groups were subdivided into the group A1 (<40 years old),A2 (40 - <50 years old),A3 (50 - <60 years old),A4(60-<70 years old)and A5 (70 -87 years old),and group B1 (<40 years old),B2(40 -<50 years old),B3 (50 -<60 years old),B4(60-<70 years old)and B5(70-87 years old).The serum AFP and CEA in 987 healthy physical examination peo-ple were measured by the electrochemiluminesence immunoassay,and then the detection results were compared among various groups.Results (1)The detection results of serum AFP and CEA had statistically

  20. Binding of insecticidal lectin Colocasia esculenta tuber agglutinin (CEA) to midgut receptors of Bemisia tabaci and Lipaphis erysimi provides clues to its insecticidal potential.

    Science.gov (United States)

    Roy, Amit; Gupta, Sumanti; Hess, Daniel; Das, Kali Pada; Das, Sampa

    2014-07-01

    The insecticidal potential of Galanthus nivalis agglutinin-related lectins against hemipterans has been experimentally proven. However, the basis behind the toxicity of these lectins against hemipterans remains elusive. The present study elucidates the molecular basis behind insecticidal efficacy of Colocasia esculenta tuber agglutinin (CEA) against Bemisia tabaci and Lipaphis erysimi. Confocal microscopic analyses highlighted the binding of 25 kDa stable homodimeric lectin to insect midgut. Ligand blots followed by LC MS/MS analyses identified binding partners of CEA as vacuolar ATP synthase and sarcoplasmic endoplasmic reticulum type Ca(2+) ATPase from B. tabaci, and ATP synthase, heat shock protein 70 and clathrin heavy chain assembly protein from L. erysimi. Internalization of CEA into hemolymph was confirmed by Western blotting. Glycoprotein nature of the receptors was identified through glycospecific staining. Deglycosylation assay indicated the interaction of CEA with its receptors to be probably glycan mediated. Surface plasmon resonance analysis revealed the interaction kinetics between ATP synthase of B. tabaci with CEA. Pathway prediction study based on Drosophila homologs suggested the interaction of CEA with insect receptors that probably led to disruption of cellular processes causing growth retardation and loss of fecundity of target insects. Thus, the present findings strengthen our current understanding of the entomotoxic potentiality of CEA, which will facilitate its future biotechnological applications.

  1. Value of Serum ProGRP,NSE and CEA Detection in Diagnosis of Small Cell Lung Cancer%血清 ProGRP,NSE 和 CEA 检测对小细胞肺癌的诊断价值

    Institute of Scientific and Technical Information of China (English)

    孙树凯; 田清武; 刘入华; 申井利; 翟玉娥; 翟木绪

    2016-01-01

    目的:探讨血清胃泌素释放肽前体(ProGRP)、神经元特异性烯醇化酶(NSE)和癌胚抗原(CEA)联合检测对小细胞肺癌(SCLC)的诊断价值。方法471例肺部肿瘤患者均来自呼吸内科和胸外科住院患者,另从健康查体中心随机选取162例健康人作为对照组。所有研究对象均空腹采血,采用电化学发光法检测其血清 ProGRP,NSE 和 CEA 水平,绘制ROC 曲线并计算曲线下面积(the area under the curve,AUC)。结果SCLC 患者血清 ProGRP 和 NSE 水平显著高于非小细胞肺癌组、肺良性病变组和正常对照组(P <0.01)。SCLC 患者血清 CEA 水平显著高于肺良性病变组和正常对照组(P<0.05)。ProGRP,NSE 和 CEA 诊断 SCLC 的 AUC 分别为0.933,0.777和0.554。ProGRP,NSE 和 CEA 诊断 SCLC 的敏感度分别为82.6%,60.4%和41.6%,特异度分别为95.2%,83.3%和71.7%。联合检测 ProGRP,NSE 和 CEA 诊断SCLC 的敏感度为91.3%,特异度为65.3%。结论血清 ProGRP 检测对 SCLC 具有较高的诊断价值;ProGRP,NSE 和CEA 的联合检测有助于 SCLC 的早期诊断。%Objective To investigate the diagnostic value of combined detection of serum gastrin-releasing peptide precursor (ProGRP),neuron specific enolization enzyme(NSE)and carcinoembryonicantigen(CEA)in small cell lung cancer(SCLC). Methods 471 patients with lung tumor from department of respiratory medicine and thoracic surgery and 162 healthy people from medical examination center were studied.Serum levels of ProGRP,NSE and CEA were detected by using electrochemi-cal luminescence method.ROC curves were drawn and the area under the curve (AUC)was calculated.Results The levels of ProGRP and NSE were significantly higher in patients with SCLC than those in NSCLC,lung benign disease group and normal control group (P <0.01).The levels of CEA were significantly higher in SCLC than those in patients with lung be-nign disease

  2. Un cabinet d'égyptologue au Siècle des lumières : le cabinet d'histoire naturelle du docteur Gagnon au Musée Stendhal de Grenoble (France), par Joëlle Rochas, de l'Université de Savoie, membre du Comité scientifique Musée Stendhal (France). An meinen lieben Freund Bernhard Wolfmayr

    OpenAIRE

    Rochas, Joëlle

    2010-01-01

    Summary. An Egyptologist's cabinet during the Enlightenment : Dr. Gagnon's natural history cabinet at the Stendhal Museum of Grenoble (France). An meinen lieben Freund Bernhard Wolfmayr. Translated by Sofia Arenzon. In 2008, Grenoble, a city located in the French Alps, has begun restoration work on the house of Dr. Gagnon, grandfather of Stendhal, a world-famous French writer. Dr. Gagnon, a true spirit of the Enlightenment, had a considerable influence on his grandson's education. Being a rea...

  3. Spanish pre-university students' use of English: CEA results from the University Entrance Examination

    Directory of Open Access Journals (Sweden)

    María Belén Díez Bedmar

    2011-12-01

    Full Text Available In this paper an updated overview of the main errors that Spanish students make when writing the English exam in the University Entrance Examination is provided. To do so, a Computer-aided Error Analysis (CEA (Dagneaux, Denness & Granger, 1998 was conducted on a representative sample of the students who took the exam in June 2008 in Jaén, and wrote a composition on the same topic. The use of the most widely-used error taxonomy, the Error Tagging Manual version 1.1. (Dagneaux, Denness, Granger & Meunier, 1996, and the analysis of the results by means of descriptive statistics foster the possibility to replicate this study and move forward in the description of the students’ written command in the foreign language at this stage. The comparison of the findings obtained in this study and those from previous (CEAs on the English exam reveals that some common tendencies may be shown.Este artículo aporta una visión general actualizada de los errores más importantes que los alumnos españoles cometen cuando escriben el examen de inglés de la Prueba de Acceso a la Universidad. Con este fin, se realizó un Análisis de Errores Informatizado (Dagneaux, Denness & Granger, 1998 en una muestra representativa de los estudiantes que realizaron el examen en Junio de 2008 en la Universidad de Jaén, y que escribieron sobre un mismo tema. El uso de la taxonomía de errores más usada, el Error Tagging Manual version 1.1. (Dagneaux, Denness, Granger & Meunier, 1996, y de la estadística descriptiva para analizar los resultados, favorecen la réplica de este estudio y la posibilidad de mejorar la descripción de la destreza escrita en la lengua extranjera. La comparación de los resultados en este artículo y otros Análisis de Errores (Informatizados previos muestran que se pueden exponer algunas tendencias comunes.

  4. 2004 annual report. Defense, safety, energy, information, health. CEA in the center of big European challenges; Rapport annuel 2004. Defense, securite, energie, information, sante. Le CEA au coeur des grands defis europeens

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This document is the 2004 annual report of the French atomic energy commission (CEA). It presents the R and D activities of the CEA in three main domains: 1 - defense and safety, maintaining perenniality of nuclear dissuasion and nuclear safety: supplying nuclear weapons to armies, maintaining dissuasion capability with the simulation program, sharing R and D means with the scientific community and the industrial world, designing and maintaining naval nuclear propulsion reactors, cleansing Marcoule and Pierrelatte facilities, monitoring treaties and fighting against proliferation and terrorism; 2 - energy, developing more competitive and cleaner energy sources: nuclear waste management, optimization of industrial nuclear activities, future nuclear systems and new energy technologies, basic research on energy, radiobiology and toxicology; 3 - information and health, valorizing industry thanks to technological research and supplying new tools for health and medical research: micro- and nano-technologies, software technologies, basic research for industrial innovation, nuclear technologies for health and bio-technologies. (J.S.)

  5. Nuclear systems of the future: international forum generation 4 and research and development projects at the Cea; Systemes nucleaires du futur: forum international generation 4 et projets de R et D du CEA

    Energy Technology Data Exchange (ETDEWEB)

    Carre, F

    2003-07-01

    To advance nuclear energy to meet future energy needs, ten countries have agreed to develop a future generation of nuclear energy systems, known as Generation 4. A technology road map to guide the Generation 4 effort was begun. This document presents the goals for these nuclear systems and the research programs of the Cea on the gas technology, GT-MHR, VHTR and GFR and the other systems as sodium Fast Neutron reactors, supercritical water and space nuclear. (A.L.B.)

  6. Training and Certification Program for Certified Energy Auditors (CEA) and Certified Building Commissioning Professionals (CBCP)

    Energy Technology Data Exchange (ETDEWEB)

    Kent, Bill

    2012-08-24

    The Association of Energy Engineers (AEE) has offered energy efficiency training and certification programs for over 30 years. During that time AEE has certified more than 22,000 professionals. All of our certification programs are the result of extensive industry research and program development and oversight by certification boards. For this project award, AEE proposed to work with the Department of Energy to utilize and extend existing industry recognized Certified Energy Auditor (CEA) and Certified Building Commissioning Professional (CBCP) programs under this Training Program Development Announcement. These expanded training programs will have significant impact in training professionals for building commissioning and energy auditing to achieve the goal of bringing existing buildings up to their optimal energy performance potential and ensuring that new buildings maintain their expected optimal level of performance. The goals and objectives of the training development project were achieved with the development of new training programs that are now being offered as self-sustaining commercial training and certification programs. These new programs are training and certifying professionals who are accomplishing the goal of increasing building energy performance in both existing and new buildings.

  7. Meeting of Directors and Heads of Department from CEA-Saclay, France

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    Directors and Heads of Department from the Saclay centre of the French atomic energy commission (CEA) visited CERN in December. They are pictured here at the LHC magnet test facility in building SM18. On the left behind the visitors are the test benches where magnets are prepared for installation in String 2: the 120-metre full-scale model of an LHC cell of the regular part of the arc, which can be seen to the right. Photos 01, 02: Left to right: Marc Dejardin, Alain Givernaud, Louis Laurent, François Kircher, Antoine Masurel, Joël Feltesse, André Menez, T. Taylor, Philippe Pradelles, Bernard Sevestre, Michel Roche, Jean-Yves Gascoin, Thierry Lieven, Michel Spiro, Jean-Pierre Pervès, Yves Lemoigne, Béatrice Reder, Georges Carola, Philippe Lebrun, Yves Bourlat, Bertrand Mercier, Jean-Paul Langlois, Patrick Laurent, Didier Moulin, Xavier Vitart, Marc Serre, Jean-Louis Pierrey, Patrick Jarry, Bruno Mansoulié, Stéphane Lequien, Hervé Barbelin, Philippe Pallier, Jean-Yves Guillamot, and Norbert Sioegel.

  8. ICL-Based OF-CEAS: A Sensitive Tool for Analytical Chemistry.

    Science.gov (United States)

    Manfred, Katherine M; Hunter, Katharine M; Ciaffoni, Luca; Ritchie, Grant A D

    2017-01-03

    Optical-feedback cavity-enhanced absorption spectroscopy (OF-CEAS) using mid-infrared interband cascade lasers (ICLs) is a sensitive technique for trace gas sensing. The setup of a V-shaped optical cavity operating with a 3.29 μm cw ICL is detailed, and a quantitative characterization of the injection efficiency, locking stability, mode matching, and detection sensitivity is presented. The experimental data are supported by a model to show how optical feedback affects the laser frequency as it is scanned across several longitudinal modes of the optical cavity. The model predicts that feedback enhancement effects under strongly absorbing conditions can cause underestimations in the measured absorption, and these predictions are verified experimentally. The technique is then used in application to the detection of nitrous oxide as an exemplar of the utility of this technique for analytical gas phase spectroscopy. The analytical performance of the spectrometer, expressed as noise equivalent absorption coefficient, was estimated as 4.9 × 10(-9) cm (-1) Hz(-1/2), which compares well with recently reported values.

  9. Enxertia herbácea em Myrtaceae nativas do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Daiane Silva Lattuada

    2010-12-01

    Full Text Available O objetivo deste trabalho foi testar a viabilidade da técnica de enxertia herbácea em frutíferas nativas da família Myrtaceae. O experimento foi realizado em casa de vegetação do Departamento de Horticultura e Silvicultura/ UFRGS, em Porto Alegre. Duas espécies de Myrtaceae nativas foram usadas, tanto como porta-enxerto quanto como enxerto, Eugenia uniflora (Pitangueira e E. involucrata (Cerejeira-do-rio-grande ou Cerejeira-do-mato, totalizando quatro combinações. O método de enxertia adotado foi por garfagem em fenda cheia, em ramos herbáceos, com diâmetro médio do porta-enxerto de 0,1cm, enquanto os ramos dos enxertos apresentavam diâmetro médio entre 0,08 a 0,1cm, para as duas espécies. As análises foram quinzenais e, após 70 dias, foram analisadas estatisticamente a pega e a altura média das brotações emitidas. O delineamento experimental foi o completamente casualizado, com quatro repetições, sendo cada unidade experimental composta de cinco enxertos. Os resultados indicaram pega de 60% na combinação Pitangueira-Pitangueira (porta enxerto - enxerto. As demais combinações mostraram-se ineficientes.

  10. CEA and AREVA HTR fuel particles manufacturing and characterization R and D Program

    Energy Technology Data Exchange (ETDEWEB)

    Charollais, F.; Perez, M.; Fonquernie, S.; Ablitzer, C.; Duhart, A.; Perrais, C.; Dugne, O.; Guillermier, P.; Harbonnier, G

    2004-07-01

    Worldwide, renewal of interest for High Temperature Reactors (HTR) moderated by graphite, using helium gas as coolant is due to the possibility offered by HTR technology to build small competitive modular units (100-300 MWe) and to produce high temperature gas required for hydrogen production or heat production. In this context, Commissariat a l'Energie Atomique (CEA) supported by AREVA, conducts R and D projects on HTR, which one is the mastering of the UO{sub 2} TRISO fuel fabrication technology including innovating prospects. The first step of the work is to recover fabrication know-how and to improve fabrication processes (for preparing the erection of a fuel pilot manufacture line of HTR particles). The second step will be the manufacturing of HTR fuel elements in purpose of irradiation tests. This publication deals with the know-how recovery and improved processes of UO{sub 2} TRISO manufacture, i.e. kernel and coatings manufacturing, the development of innovative characterization methods, a modelling approach of CVD processes and the status of the future laboratory manufacture line. Alternative fuel designs are also investigated, for instance the way of manufacturing UCO and UC{sub x} kernels with higher refractory coating material such as ZrC. (authors)

  11. EURATOM-CEA association contributions to the 18. IAEA fusion energy conference

    Energy Technology Data Exchange (ETDEWEB)

    Ghendrih, Ph.; Peysson, Y.; Hoang, G.T. [and others

    2000-12-01

    The 9 contributions of EURATOM-Cea association to the fusion energy conference hold at Sorrento are gathered in this document with 7 additional papers. The different titles are: 1) Ergodic divertor experiments on the route to steady state operation of Tore-Supra, 2) High power lower hybrid current drive experiments in Tore-Supra tokamak, 3) Electron transport and improved confinement on Tore-Supra, 4) ECRH experiments and developments for long pulse in Tore-Supra, 5) Impurity penetration and contamination in Tore-Supra ergodic divertor experiments, 6) Real time plasma feed-back control: an overview of Tore-Supra achievements, 7) Numerical assessment of the ion turbulent thermal transport scaling laws, 8) Design of next step tokamak: consistent analysis of plasma flux consumption and poloidal, 9) Large superconducting conductors and joints for fusion magnets: from conceptual design to test at full size scale, 10) Burst-prone transport in tokamaks with internal transport barriers, 11) Electrostatic turbulence with finite parallel correlation length and radial electric field generation, 12) Theoretical issues in tokamak confinement: internal-edge transport barriers and runaway avalanche confinement, 13) Core and edge confinement studies with different heating methods in JET, 14) Confinement and transport studies of conventional scenarios in ASDEX upgrade, 15) First test results for the ITER central solenoid model coil, and 16) Progress of the ITER central solenoid model coil program.

  12. LAS GESNERIÁCEAS DEL DEPARTAMENTO DEL QUINDÍO, COLOMBIA

    Directory of Open Access Journals (Sweden)

    Oscar Humberto MARÍN-GÓMEZ

    2015-01-01

    Full Text Available Colombia es el país neotropical con mayor diversidad de Gesneriaceae. Sin embargo hay vacíos en el conocimiento de los patrones de distribución y ecología de esta familia, debido a su complejidad taxonómica. En este trabajo se presenta una lista de Gesneriaceae para el departamento del Quindío con datos de hábitat y distribución altitudinal. Se revisaron las colecciones del Herbario Nacional Colombiano (COL y Herbario de la Universidad del Quindío (HUQ y se realizó trabajo de campo entre 2009 y 2014 en 70 localidades del Quindío. Se encontraron 43 especies y 11 géneros, con una mayor representación de Columnea, Besleria y Kohleria; nueve especies fueron nuevos registros para el Quindío, tres fueron endémicas y cinco especies nuevas para la ciencia. La mayor riqueza se encontró en los bosques montanos entre 1800 y 2400 m s.n.m., principalmente en interior bosque y cañadas. Los resultados de este trabajo constituyen una línea base para dirigir la investigación en ecología, conservación y su potencial ornamental de las gesneriáceas presentes en el Quindío.

  13. Test Results of the Third LHC Main Quadrupole Magnet Prototype at CEA/Saclay

    CERN Document Server

    Derégel, J; Gourdin, C; Hervieu, M; Ogitsu, T; Peyrot, M; Rifflet, J M; Schild, T; Simon, F; Tortschanoff, Theodor; Tsuchiya, K

    2002-01-01

    The construction of the third second-generation main quadrupole magnet prototype for LHC has been completed at CEA/Saclay in November 2000. The magnet was tested at 1.9 K. Similarly to the two first ones, this prototype has exceeded the operating current in one training step and exhibited excellent training memory after a thermal cycle. This paper describes the quench performance and quench start localization determined by means of voltage-taps and a quench antenna system developed in collaboration with KEK. As this magnet was equipped with capacitive gauges, the stresses during cool-down and powering have been recorded and are in agreement with FE computations. The newly designed quench heaters have improved efficiency and reproducibility compared to those of the first generation. Magnetic measurements have been performed at various stages. The cold measurements show minor differences with those at room temperature and are similar to those of the two first magnets of this design. These results prove that the...

  14. METABOLISMO ÁCIDO DE LAS CRASULÁCEAS Crassulacean Acid Metabolism

    Directory of Open Access Journals (Sweden)

    THOMAS DAVID GEYDAN

    Full Text Available Se presenta una revisión del metabolismo ácido de las Crasuláceas, caracterizado por la ocurrencia, actividad y plasticidad del mecanismo desde un punto de vista fisiológico, bioquímico y molecular, enmarcado por la presencia de las denominadas cuatro fases de dicho metabolismo y su repercusión y expresión por diversas restricciones hídricas a nivel ecológico. Se presentan las principales enzimas y metabolitos básicos para el funcionamiento del metabolismo CAM, así como su modo de acción y control celular. Finalmente, se muestra que la plasticidad fenotípica en patrones de expresión CAM se encuentra mediada por condiciones ambientales y por señalizaciones moleculares.A review of Crassulacean acid metabolism is presented, characterized by showing the occurrence, activity and plasticity of these complex mechanism at the physiological, biochemical and molecular level, framed by the presence of the denominated four phases in CAM and its repercussion and expression due to different stresses in an ecological context. The basic enzymes, and metabolites necessary for the optional functioning of CAM are presented as well as their mode of action and cellular control. Finally, it is shown how environmental conditions and molecular signalling mediate the phenotypic plasticity.

  15. Synthesis of cadmium, lead and copper alginate nanobeads as immunosensing probes for the detection of AFP, CEA and PSA.

    Science.gov (United States)

    Wang, Zifeng; Liu, Na; Feng, Feng; Ma, Zhanfang

    2015-08-15

    A double-water-in-oil-emulsion procedure was designed to synthesize cadmium, lead and copper alginate nanobeads less than 200n m diameter under mild conditions. The cadmium, lead and copper alginate nanobeads can be activated to immobilize biomacromolecules and can directly produce distinctive electrochemical signals. Using the novel alginate nanobeads labeled with antibodies as electrochemical probes, a sandwich-type immunosensor was constructed using AFP, CEA and PSA as model analytes. This proposed immunosensor shows wide linear range with detection limits of 0.01, 0.0086 and 0.0075 ng mL(-1) for AFP, CEA and PSA, respectively. Analysis of clinical serum samples using this immunosensor was well consistent with the data determined by the enzyme-linked immunosorbent assay (ELISA). It suggested that the alginate nanobeads electrochemical probes could be generally extended to other multiple analytes detection.

  16. Computed tomography of pulmonary changes in rheumatoid arthritis: carcinoembryonic antigen (CEA) as a marker of airway disease.

    Science.gov (United States)

    Koch, Milene Caroline; Pereira, Ivânio Alves; Nobre, Luiz Felipe Souza; Neves, Fabricio Souza

    2016-04-01

    Rheumatoid arthritis (RA) classically affects the joints, but can present extra-articular manifestations, including pulmonary disease. The present study aimed to identify possible risk factors or laboratory markers for lung involvement in RA, particularly the presence of rheumatoid factor (RF), anti-citrullinated peptide antibodies (ACPA), and tumor markers, by correlating them with changes observed on chest high-resolution computerized tomography (HRCT). This cross-sectional study involved RA patients who were examined and questioned by a specialist physician and later subjected to chest HRCT and blood collection for measurement of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), ACPA (anti-vimentin and/or anti-CCP3), and the tumor markers carcinoembryonic antigen (CEA), CA 125, CA 15-3, and CA 19-9. A total of 96 patients underwent chest HRCT. The most frequent findings were bronchial thickening (27/28.1 %) and bronchiectasis (25/26 %). RF was present in 63.2 % of patients (55/87), and ACPA (anti-vimentin or anti-CCP3) was present in 72.7 % of patients (64/88). CEA levels were high in 14 non-smokers (37.8 %) and 23 smokers (62.2 %). CA-19-9 levels were high in 6 of 86 patients (7.0 %), CA 15-3 levels were high in 3 of 85 patients (3.5 %), and CA 125 levels were high in 4 of 75 patients (5.3 %). Multivariate analysis indicated a statistically significant association between high CEA levels and the presence of airway changes in patients with RA (p = 0.048). CEA can serve as a predictor of lung disease in RA and can help identify individuals who require more detailed examination for the presence of respiratory disorders.

  17. A Case of Radiation Fibrosis Appearing as Mass-Like Consolidation after SBRT with Elevation of Serum CEA

    Directory of Open Access Journals (Sweden)

    Kotaro Terashima

    2010-01-01

    Full Text Available We report a case of radiation fibrosis appearing as mass-like consolidation, which was difficult to distinguish from local recurrence. A 72-year-old woman was diagnosed as having primary lung cancer (cT1N0M0 stage IA in the right upper lobe and was treated with SBRT of 48 Gy in 4 fractions. After 12 months, mass-like consolidation appeared around the irradiated area, and after 13 months, it had increased in size. FDG-PET revealed high uptake (SUV max=5.61 for the consolidation. CT-guided biopsy was performed, but we could not confirm the diagnosis. Considering her poor respiratory function and her age, short-interval follow-up was performed. After 15 months, the consolidation enlarged at the dorsal side, and carcinoembryonic antigen (CEA became elevated (14.6 ng/mL. Serum KL-6 (436 U/mL and SP-D (204 ng/mL were also elevated. However, after 16 months, serum CEA slightly decreased. The consolidation gradually retracted on follow-up CT images. CEA, KL-6, and SP-D were also decreased by degrees. After 40 months, there is no evidence of local recurrence.

  18. Comparative study of CEA and CA19-9 in esophageal, gastric and colon cancers individually and in combination (ROC curve analysis)

    Institute of Scientific and Technical Information of China (English)

    Bhawna Bagaria; Sadhna Sood; Rameshwaram Sharma; Soniya Lalwani

    2013-01-01

    Objective:To determine the clinical serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods:The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic (ROC) curves were plotted. Results:Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined:in esophageal cancer, sensitivity=28%, negative predictive value (NPV)=61.72%, and AUC=0.742 (SE=0.05), with a significance level of P Conclusion:CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.

  19. Estrutura da vegetação herbácea em paisagens ciliares no sul de Santa Catarina, Brasil

    Directory of Open Access Journals (Sweden)

    Aline Votri Guislon

    2016-06-01

    Full Text Available As características estruturais e ecológicas da vegetação herbácea fazem com que ela seja sensível às alterações do ambiente, atuando como indicador da qualidade ambiental. No entanto, o estudo dessa comunidade ainda é incipiente em regiões neotropicais. Este estudo descreve a florística e os aspectos fitossociológicos da vegetação herbácea terrícola na mata ciliar de sete rios, no município de Urussanga, sul do estado de Santa Catarina, além de analisar e quantificar o status do conhecimento científico relacionado às herbáceas terrícolas no Brasil. Foram levantadas 320 unidades amostrais de 4 m², nas quais todos os indivíduos foram identificados e dados relacionados aos parâmetros fitossociológicos foram coletados. A amostragem resultou em 58 táxons, 38 pertencentes às angiospermas e 20 às samambaias, distribuídos em 25 famílias botânicas. Poaceae apresentou maior riqueza, com 11 espécies. Estruturalmente, destacaram-se Goeppertia monophylla (Vell. Borchs. e S. Suárez, Blechnum brasiliense Desv. e Heliconia farinosa Raddi. A forma de vida mais frequente foi a hemicriptófita reptante. Os resultados revelam uma elevada riqueza de herbáceas terrícolas adaptadas às condições climáticas das matas ciliares, contribuindo para a diversidade da flora regional. Quanto à produção científica, foram encontrados 50 trabalhos indexados nas bases de dados eletrônicas (1990 a 2015, com destaque ao ano de 2011, que teve maior produção científica enfocando as herbáceas terrícolas. Embora com baixo número, a quantidade de indexações tende a crescer, em virtude do avanço da tecnologia de acesso às bases de dados e pela crescente adesão de periódicos em portais de busca.

  20. Produção integrada de Anonáceas no Brasil

    Directory of Open Access Journals (Sweden)

    Raimundo Braga Sobrinho

    2014-01-01

    Full Text Available Os conceitos técnicos e operacionais contidos na Produção Integrada (PI vêm atender de forma direta às exigências dos órgãos nacionais e internacionais que fiscalizam o comércio de "commodities", dando ênfase à segurança e a qualidade dos alimentos produzidos e consumidos pela população. A garantia da produção de um alimento seguro e rastreável é alcançada mediante o esforço harmônico de todos os integrantes da cadeia produtiva. Esse sistema pressupõe o cumprimento das Normas Técnicas Específicas (NTE para cada produto, permitindo o controle efetivo do sistema produtivo agropecuário por meio do monitoramento de todas as etapas na cadeia produtiva. Esse conceito teve início com o Manejo Integrado de Pragas (MIP e, posteriormente, expandiu-se para uma visão holística, estruturada em quatro pilares de sustentação: organização da base produtiva; sustentabilidade do sistema; monitoramento dos processos; e formação de um banco de dados. Dentro desta visão, insere-se a Produção Integrada de Anonáceas, projeto iniciado em 2010, com apoio do CNPq/MAPA/EMBRAPA e instituições parceiras. As anonáceas representam um nome genérico para designar as plantas da família Annonaceae constituída por cerca de 120 gêneros e em torno de 2.300 espécies. No Brasil, estão registrados 29 gêneros, dentro dos quais cerca de 260 espécies. Entre as espécies de maior importância comercial, destacam-se a graviola (Annona muricata L., pinha (Annona squamosa L., cherimólia (Annona cherimólia, Mill. e a atemoia, hibrido de A. cherimólia e A. squamosa. Essas frutas têm alta aceitação pelo seu sabor e possibilidade de uso para consumo in natura, sucos e geleias. As áreas comercialmente cultivadas são concentradas nos Estados do Nordeste do Brasil. Os Estados de maior concentração: Bahia para graviola e pinha, Alagoas para pinha e São Paulo para atemoia. Os resultados de pesquisa envolvendo toda a cadeia produtiva dessas

  1. Design of the helium cooled lithium lead breeding blanket in CEA: from TBM to DEMO

    Science.gov (United States)

    Aiello, G.; Aubert, J.; Forest, L.; Jaboulay, J.-C.; Li Puma, A.; Boccaccini, L. V.

    2017-04-01

    The helium cooled lithium lead (HCLL) blanket concept was originally developed in CEA at the beginning of 2000: it is one of the two European blanket concepts to be tested in ITER in the form of a test blanket module (TBM) and one of the four blanket concepts currently being considered for the DEMOnstration reactor that will follow ITER. The TBM is a highly optimized component for the ITER environment that will provide crucial information for the development of the DEMO blanket, but its design needs to be adapted to the DEMO reactor. With respect to the TBM design, reduction of the steel content in the breeding zone (BZ) is sought in order to maximize tritium breeding reactions. Different options are being studied, with the potential of reaching tritium breeding ratio (TBR) values up to 1.21. At the same time, the design of the back supporting structure (BSS), which is a DEMO specific component that has to support the blanket modules inside the vacuum vessel (VV), is ongoing with the aim of maximizing the shielding power and minimizing pumping power. This implies a re-engineering of the modules’ attachment system. Design changes however, will have an impact on the manufacturing and assembly sequences that are being developed for the HCLL-TBM. Due to the differences in joint configurations, thicknesses to be welded, heat dissipation and the various technical constraints related to the accessibility of the welding tools and implementation of non-destructive examination (NDE), the manufacturing procedure should be adapted and optimized for DEMO design. Laser welding instead of TIG could be an option to reduce distortions. The time-of-flight diffraction (TOFD) technique is being investigated for NDE. Finally, essential information expected from the HCLL-TBM program that will be needed to finalize the DEMO design is discussed.

  2. Immunohistology of carcinoembryonic antigen (CEA)-expressing tumors grafted in nude mice after radioimmunotherapy with 131I-labeled bivalent hapten and anti-CEA x antihapten bispecific antibody.

    Science.gov (United States)

    Gautherot, E; Kraeber-Bodéré, F; Daniel, L; Fiche, M; Rouvier, E; Saï-Maurel, C; Thedrez, P; Chatal, J F; Barbet, J

    1999-10-01

    We have developed a pretargeting strategy, called the Affinity Enhancement System (AES), which uses bispecific antibodies (BsF(ab')2) to target radiolabeled bivalent haptens to tumor cells. We performed several radioimmunotherapy (RIT) experiments in nude mice grafted with LS174T colon carcinoma or TT medullary thyroid cancer. Mice were treated with 131I-labeled di-DTPA-indium-tyrosyl-lysine bivalent hapten (75-112 MBq) administered 15-48 h after anti-CEA x anti-DTPA-indium BsF(ab')2. Immunohistological studies were performed on tumors at their minimal relative volume (TT), on stabilized tumor nodules (LS174T), and on regrowing tumors (TT and LS174T). Untreated tumors were used as controls. On microscopic examination, regrowing tumors (2 months posttherapy) were similar to untreated tumors with cells showing their respective typical morphology (large cells with a high nucleocytoplasmic ratio for TT, small and very undifferentiated cells for LS174T). However, regrowing tumors showed larger necrotic areas and a higher mitotic index correlated with Ki-67 antigen staining. Immunostaining for CEA was as strong as for controls. By contrast, the immunohistology of TT tumors at their minimal relative volume (1 month posttherapy) or of LS174T residual nodules (8 months posttherapy) showed decreased mitotic indices correlated with poor Ki-67 antigen staining. Some clusters of LS174T presented with features of glandular lumen, which suggested a more differentiated and less aggressive status. In TT tumors, CEA expression remained unchanged (80-100% membrane and cytoplasmic staining), whereas only 70% of the LS174T tumors were stained, with 58% loss of the membrane expression. Repeated treatment early after the tumor has reached its minimal relative volume should thus be efficient and improve the overall efficacy of AES RIT.

  3. Actinides exposure: review of Ca-DTPA injections inside Cea-Cogema plants; Exposition aux actinides: bilan des injections de Ca-DTPA dans les centres CEA-Cogema

    Energy Technology Data Exchange (ETDEWEB)

    Grappin, L.; Berard, P.; Beau, P.; Carbone, L.; Castagnet, X.; Courtay, C.; Le Goff, J.P.; Menetrier, F.; Neron, M.; Piechowski, J. [CEA Cadarache, Dir. de l' Energie Nucleaire, Dept. de Soutien en surete et securite, Sev. de Sante au Travail, 13 - Saint-Paul-lez-Durance (France)

    2006-07-01

    Ca-DTPA has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This report is a survey of the injections administered of Ca-DTPA as a chelating molecule. This report will be a part of the AMM process for Ca-DTPA by intravenous administration submitted by the Central Pharmacy of the french Army. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contaminations were reported. These employees were followed by occupational physicians according to the current regulations. The first part of the report is a synthesis of the most recent findings. Due to its short biological period and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary. The second part presents data concerning these 1158 injections (way of contamination, posology, adverse effects...). These incidents took place at work, were most often minor, not requiring follow-up treatment. A study concerning the effectiveness of the product was done on a group of people having received 5 or more injections. These results were compared with effectiveness estimated from theoretical basis. Posologies and therapeutic schemes were proposed based on these observations. Additional studies are needed to confirm these findings. This document is the first synthesis in this field. It is the result of a collective work having mobilized the occupational medicine departments, the laboratories of CEA and COGEMA and a working group CEA-COGEMA-SPRA. (authors)

  4. Evaluation of the radiology state at the CEA/Fontenay-aux-Roses and its environment; Point sur l'etat radiologique du CEA/Fontenay-aux-Roses et de son environnement

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    Since 1946 the nuclear installations followed one other at the CEA of Fontenay-aux-Roses still their gradual stop the last ten years, except two installations INB34 and INB73, necessary for the wastes management. Today these installations form the subject of a drainage program. The public opinion is regularly informed on this program since 1999. This document presents the stock of the actions realized since this date: the track keeping of the sites activities impacts on the environment and the actions realized since 1999. (A.L.B.)

  5. Positive predictive value of CEA and Ca19-9 as tumor markers for recurrent colorectal cancer in cases where conventional work-up fail to localize disease.

    Directory of Open Access Journals (Sweden)

    Yana Bocheva

    2015-12-01

    Full Text Available Introduction: Routine surveillance of colorectal cancer includes serial measurements of CEA levels. Although not routinely indicated Ca 19-9 is also a tool for recurrence. When any of these serum markers is elevated during follow up, this could represent a recurrence. The management of elevated tumor marker levels include clinical exams, endoscopy and conventional imaging –ultrasound, CT, MRI.Objective: To evaluate the positive predictive value of CEA and Ca19-9 as tumor markers for recurrent colorectal cancer in cases where conventional imaging and endoscopic studies fail to localize disease.Materials and methods: A total of 75 patients with elevated CEA and/or Ca19-9 serum levels and negative endoscopic exam as well as negative abdominal CT and Chest X-ray were included in the study. CEA levels were tested in 50 patients. Ca 19-9 was tested in 65 patients. 34 of the patients had both markers tested. All patients underwent whole body 18F-FDG PET/CT. Patients with negative of equivocal PET scan were further followed up (10 to 24 months.Results: Based on the reference standard – the results from PET/CT, if positive and the results from follow-up in cases of negative or equivocal scans, the positive predictive value of Ca 19-9 was 84% and that of CEA -83%. There was no significant difference in the PPV of Ca19-9 and CEA.Conclusion: Elevated CEA and Ca 19-9 levels in patients under active surveillance after operation for colorectal cancer have high positive predictive value for recurrence, even in cases where conventional work-up – endoscopy and CT don’t localize disease.

  6. Super-Phenix benchmark used for comparison of PNC and CEA calculation methods, and of JENDL-3.2 and CARNAVAL IV nuclear data

    Energy Technology Data Exchange (ETDEWEB)

    Hunter, S.N. [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

    1998-02-01

    The study was carried out within the framework of the PNC-CEA collaboration agreement. Data were provided, by CEA, for an experimental loading of a start-up core in Super-Phenix. This data was used at PNC to produce core flux snapshot calculations. CEA undertook a comparison of the PNC results with the equivalent calculations carried out by CEA, and also with experimental measurements from SPX. The results revealed a systematic radial flux tilt between the calculations and the reactor measurements, with the PNC tilts only {approx}30-40% of those from CEA. CEA carried out an analysis of the component causes of the radial tilt. It was concluded that a major cause of radial tilt differences between the PNC and CEA calculations lay in the nuclear datasets used: JENDL-3.2 and CARNAVAL IV. For the final stage of the study, PNC undertook a sensitivity analysis, to examine the detailed differences between the two sets of nuclear data. The sensitivity analysis showed that a relatively small number of nuclear data items contributed the bulk of the radial tilt difference between calculations with JENDL-3.2 and with CARNAVAL IV. A direct comparison between JENDL-3.2 and CARNAVAL IV data revealed the following. The Nu values showed little difference. The only large fission cross-section differences were at low energy. Although down-scattering reactions showed some large fractional differences, absolute differences were negligible compared with in-group scattering; for in-group scattering fractional differences were up to {approx}75%, but generally <20%. There were many large differences in capture cross-sections, generally {approx}30-200%. (J.P.N.)

  7. Relationship between peripheral and mesenteric serum levels of CEA and CA 242 with staging and histopathological variables in colorectal adenocarcinoma Níveis séricos periféricos e mesentéricos de CEA e CA 242, estadiamento e variáveis histopatológicas no adenocarcinoma colorretal

    Directory of Open Access Journals (Sweden)

    Mauro Lamelas Cardoso

    2009-10-01

    Full Text Available PURPOSE: To compare histopathological variables and staging in colorectal adenocarcinoma cases with CEA and CA 242 in peripheral and mesenteric blood. METHODS: In 169 individuals underwent surgery for colorectal cancer, CEA and CA 242 were analyzed and compared to mesenteric and peripheral blood and correlated with macroscopic tumor's morphology and size, degree of cell differentiation, venous, neural and lymphatic involvement and TNM classification. RESULTS: There was a difference between the mesenteric (M and peripheral (P serum levels of CEA (p=0.020. Higher levels of markers were correlated with venous invasion CEA (P p=0.013, CEA (M p=0.05, CA 242 (M p=0.005 and CA 242 (P p=0.038; with advanced staging CEA (P OBJETIVO: Comparar variáveis histopatológicas e graus de estadiamento do adenocarcinoma colorretal com níveis sanguíneos periféricos e mesentéricos de CEA e CA-242. MÉTODOS: Em 169 doentes submetidos ao tratamento cirúrgico por adenocarcinoma colorretal, CEA e CA-242 foram analisados e comparados quanto aos níveis sanguíneos periféricos e mesentéricos e correlacionados com o tamanho e a morfologia macroscópica do tumor, grau de diferenciação celular, invasões venosa, linfática, neural e a classificação TNM. RESULTADOS: Verificou-se diferença significante entre o nível sérico mesentérico e periférico de CEA (p= 0,02. Níveis séricos mais elevados dos marcadores foram observados e correlacionados com invasão venosa, CEA (P p=0,013, CEA(M, p=0,05, CA-242 (M p=0,005 e CA-242 (P p=0,038. Grau de estadiamento TNM avançado foi associado com CEA(P < CEA(M p<0,05, CA-242(P < CA-242(M p<0,05. Nas maiores dimensões tumorais constatou-se CEA(P < CEA(M p=0,001 e CA 242 (P < CA 242 (M (p < 0.001. O CA 242 periférico e mesentérico aumentados associaram-se com a invasão neural, p=0.014 e p=0.003, respectivamente. CONCLUSÕES: O nível sérico mesentérico de CEA é superior ao nível sérico periférico. Os níveis s

  8. Research and development program for PWR safety at the CEA reactor thermal hydraulics laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Bernard, M. [CEA, Grenoble (France)

    1995-04-15

    Since the start of the French electronuclear program, the three partners Fermate, EDF and Cea (DRN and IPSN) have devoted considerable effort to research and development for safety issues. In particular an important program on thermal hydraulics was initiated at the beginning of the seventies. It is illustrated by the development of the CATHARE thermalhydraulic safety code which includes physical models derived from a large experimental support program and the construction of the BETHSY integral facility which is aimed to assess both the CATHARE code and the physical relevance of the accident management procedures to be applied on reactors. The state of the art on this program is described with particular emphasis on the capabilities and the assessment of the last version of CATHARE and the lessons drawn from 50 BETHSY tests performed so far. The future plans for safety research cover the following strategy: - to solve the few problems identified on present computing tools and extend the assessment - to solve the few problems identified on present computing tools and extend the assessment - to perform safety studies on the basis of plant operation feedback - to contribute to treating the safety issues related to the future reactors and in particular the case of severe accidents which have to be taken into account from the design stage. The program on severe accidents is aimed to support the design studies performed by the industrial partners and to provide computing tools which model the various phases of severe accidents and will be validated on experiments performed with real and simulating materials. The main lines of the program are: - the development of the TOLBIAC 3D code for the thermal hydraulics of core melt pools, which will be validated against the Bali experiment presently under construction - the Sultan experiment, to study the capability of cooling by external flooding of the reactor vessel - the development of the MC-3D code for core melt

  9. LAS GESNERIÁCEAS DEL DEPARTAMENTO DEL QUINDÍO, COLOMBIA

    Directory of Open Access Journals (Sweden)

    Oscar Humberto Marín-Goméz

    2014-12-01

    Full Text Available Colombia es el país neotropical con mayor diversidad de Gesneriaceae. Sin embargo hay vacíos en el conocimiento de los patrones de distribución y ecología de esta familia, debido a su complejidad taxonómica. En este trabajo se presenta una lista de Gesneriaceae para el departamento del Quindío con datos de hábitat y distribución altitudinal. Se revisaron las colecciones del COL y HUQ y se realizó trabajo de campo entre 2009 y 2014 en 70 localidades del Quindío. Se encontraron 43 especies y 11 géneros, con una mayor representación de Columnea, Besleria y Kohleria; nueve especies fueron nuevos registros para el Quindío, tres fueron endémicas y cinco especies nuevas para la ciencia. La mayor riqueza se encontró en los bosques montanos entre 1800 m y 2400 m, principalmente en interior bosque y cañadas. Los resultados de este trabajo constituyen una línea base para dirigir la investigación en ecología, conservación y su potencial ornamental de las gesneriáceas presentes en el Quindío.ABSTRACTColombia is the most diverse Neotropical country of Gesneriaceae. Nevertheless, there are gaps in knowledge of the distribution patterns and ecology of this family because of their taxonomic complexity. A list of the Gesneriaceae of the Quindío department with data for habitat and altitudinal distribution is presented in this paper. The herbarium collections of COL and HUQ were reviewed and fieldwork was carried out between 2009 and 2014 in 70 localities of Quindío. Forty three species and 11 genera were found, with a larger representation of Columnea, Besleria and Kohleria genera; nine species were new records for the Quindío; three were endemic and five species are new to science. The greatest richness was found in the montane forest between 1800 m and 2400 m, mainly in forested areas and streams. The results of this work constitute a baseline to conduct research in ecology, conservation and ornamental potential of Gesneriaceae

  10. Sobre la presencia de cactáceas naturalizadas en la costa meridional de Cataluña

    Directory of Open Access Journals (Sweden)

    Sanz-Elorza, Mario

    2004-06-01

    Full Text Available The authors report on the finding of eight new alien cacti naturalised in the Baix Camp (Tarragona. Three of these are new records for Europe, two are new records for Spain and one is a first record for Tarragona province. Two further species are not new floristic records however some revision of their status in Catalonia is required. Discussed is the extensive use of alien plant species in garden design in the area and the mildness of the local climatic conditions which has resulted in the greatest accumulation of naturalised cacti in Europe.En una riera de la comarca del Baix Camp (Tarragona hemos encontrado ocho especies de cactáceas alóctonas naturalizadas. De ellas, tres son nuevas para Europa, dos nuevas para España, una nueva para la provincia de Tarragona y, finalmente, otras dos sin ser novedad florística requieren aclaraciones en lo concerniente a su estatus en Cataluña. Este hallazgo representa la mayor biodiversidad de cactáceas citada hasta el momento para toda Cataluña, para toda la Península Ibérica e incluso para toda Europa. La introducción de especies exóticas en general y de cactáceas en particular se ve favorecida en esta comarca de la costa mediterránea por el desarrollo de una jardinería basada casi exclusivamente en elementos foráneos y en la existencia de una climatología muy favorable.

  11. Research at the CEA in the field of safety in 2nd and 3rd generation light water reactors

    Science.gov (United States)

    Billot, Philippe

    2012-05-01

    The research programs at the CEA in the field of safety in nuclear reactors are carried out in a framework of international partnerships. Their purpose is to develop studies on: The methods allowing for the determination of earthquake hazards and their consequences; The behaviour of fuel in an accident situation; The comprehension of deflagration and detonation phenomena of hydrogen and the search for effective prevention methods involving an explosion risk; The cooling of corium in order to stop its progression in and outside the vessel thereby reducing the risk of perforating the basemat; The behaviour of the different fission product families according to their volatility for the UO2 and MOX fuels.

  12. El metabolismo ácido de las crasuláceas: diversidad, fisiología ambiental y productividad

    OpenAIRE

    José Luis Andrade; Erick de la Barrera; Casandra Reyes García; M. Fernanda Ricalde; Gustavo Vargas Soto; Carlos Cervera, J

    2007-01-01

    México posee una gran diversidad de especies con el Metabolismo Ácido de las Crasuláceas (CAM). Las especies c o n este metabolismo pueden crecer en sitios donde la disponibilidad de agua es infrecuente, como son las zonas áridas y semiáridas y las copas de los árboles, o como hidrofitas en sitios con poca disponibilidad de CO2. Esta revisión presenta aspectos metodológicos, evolutivos, ecológicos y fisiológicos de este tipo de fotosíntesis. Además, se presentan datos de estudios recientes re...

  13. Rapport d'étude : La perception des risques majeurs par les riverains du CEA de Cadarache

    OpenAIRE

    Lopez, Alexia; Régner, Isabelle; Schleyer-Lindenmann, Alexandra

    2015-01-01

    Ce rapport d'étude vient répondre aux interrogations de son commanditaire, la CLI (Commission Local d'Information) du CEA (Commissariat à l'énergie Atomique) de Cadarache. Il s'organise en trois partie : une première partie établit un état des lieux des connaissances des risques majeurs par les habitants. Les risques majeurs officiellement recensés sont : le risque feu de forêt, le risque inondation, le risque sismique, le risque de mouvement de terrain, le risque de rupture de barrage, et le...

  14. Sandia National Laboratories results for the 2010 criticality accident dosimetry exercise, at the CALIBAN reactor, CEA Valduc France.

    Energy Technology Data Exchange (ETDEWEB)

    Ward, Dann C.

    2011-09-01

    This document describes the personal nuclear accident dosimeter (PNAD) used by Sandia National Laboratories (SNL) and presents PNAD dosimetry results obtained during the Nuclear Accident Dosimeter Intercomparison Study held 20-23 September, 2010, at CEA Valduc, France. SNL PNADs were exposed in two separate irradiations from the CALIBAN reactor. Biases for reported neutron doses ranged from -15% to +0.4% with an average bias of -7.7%. PNADs were also exposed on the back side of phantoms to assess orientation effects.

  15. Ocorrência de murcha bacteriana em helicônias e musácea ornamental no Distrito Federal

    OpenAIRE

    Zoccoli, Débora Maria; Tomita, Celso Katsuhiro; Uesugi,Carlos Hidemi

    2009-01-01

    Plantas de Heliconia spp. e Musa spp. apresentando murcha foram observadas em plantio comercial no Distrito Federal. Testes laboratoriais e de inoculação confirmaram como sendo a bactéria Ralstonia solanacearum biovar 1 raça 2 responsável pela doença. Este é o primeiro relato da presença da bactéria em helicônia e musácea ornamental na região. _______________________________________________________________________________ ABSTRACT Plants of Heliconia spp. and Musa spp. presenting wilt were...

  16. The clinical significance of preoperative serum CEA,β-HCG and CXs detection in the diagnosis of non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    Xian-Hua Yang; Juan Chen

    2016-01-01

    Objective:To study the clinical significance of preoperative serum CEA,β-HCG and CXs detection in the diagnosis of non-small cell lung cancer and provide reference for clinical diagnosis and disease treatment.Methods:Non-small cell lung cancer patients treated in our hospital from April 2009 to April 2014 were analyzed. Correlation between preoperative serum CEA,β-HCG as well as Cxs and clinical stages as well as prognosis of non-small cell lung cancer was assayed. Healthy subjects in our hospital during the same period were taken as control group.Results:Serum CEA,β-HCG and Cxs had no obvious correlation with patients’ age and gender, but CEA andβ-HCG had negative correlation with the clinical stages and prognosis of non-small cell lung cancer while Connexin43 had positive correlation with the clinical stages and prognosis of non-small cell lung cancer.Conclusions:Preoperative serum CEA combined withβ-HCG and CXs detection can be taken as key molecules in clinical diagnosis and prognosis of non-small cell lung cancer.

  17. Cea and CISBIO-international create the -GIP sources HA- and revise their strategy for the management of disused sealed sources; Le CEA et CISBIO-international creent le GIP sources HA, et revisent leur strategie de gestion des sources scellees usagees

    Energy Technology Data Exchange (ETDEWEB)

    Sevestre, B.; Crabol, B.; Lamberton, I. [GIP sources HA, 91 - Gif-sur-Yvette (France)

    2010-10-15

    According to French regulation, CEA and CISBIO, who have distributed many sealed sources in the past, have to recover all the disused sources. During 2009, CEA and CISBIO created the 'groupement d'interet public (GIP) sources HA', with the objective of recovering and managing high-activity sealed sources (HASS), mainly cobalt-60 and caesium-137, distributed in France. CEA and CISBIO can also recover and repatriate similar sources or any other types of sealed sources distributed by them in foreign countries, when the user has no national solution, or when international organisations, such as the IAEA, identify a security issue. With the objective of optimising this mission, GIP, CEA and CISBIO are ready to cooperate with the present source suppliers who may need the use of hot cells in France, may contribute to some repatriation operations, or may recycle some batches of recovered sealed sources not yet conditioned as waste packages. (authors)

  18. A sensitive label-free amperometric CEA immunosensor based on graphene-nafion nanocomposite film as an enhanced sensing platform.

    Science.gov (United States)

    Li, Yan; Yang, Wei-Kang; Fan, Man-Qi; Liu, Ao

    2011-01-01

    A novel approach to fabricate a label-free amperometric immunosensor for the detection of carcinoembryonic antigen (CEA) was described. Herein, methylene blue (MB), gold nanoparticles (AuNPs) and carcinoembryonic antibody (anti-CEA) were layer-by-layer assembled on the graphene-Nafion nanocomposite film-modified electrode by means of a self-assembling technique and the opposite-charged adsorption. Subsequently, the stepwise self-assembling procedure of the immunosensor was further characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The factors influencing the performance of the resulting immunosensor were studied in detail. The developed procedure showed improved features, including larger amount and higher immunoactivity of the immobilized antibody and repeatable regeneration of the sensor, as well as direct, rapid and simple determination for the antigen without multiple separation and labeling steps. The immunosensor could detect the target protein in a range of 0.5 to 120 ng/mL with a limit of 0.17 ng/mL (at 3σ). Finally, the immunosensing system was evaluated on several clinical samples. Analytical results were found to be in satisfactory agreement with those detected by the enzyme-linked immunosorbent assay (ELISA) method, indicating that this new method was a promising alternative tool for clinical diagnosis.

  19. Neutron Activation Foil and Thermoluminescent Dosimeter Responses to a Polyethylene Reflected Pulse of the CEA Valduc SILENE Critical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McMahan, Kimberly L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Yi-kang [French Atomic Energy Commission (CEA), Saclay (France); Gagnier, Emmanuel [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette; Authier, Nicolas [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Piot, Jerome [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Jacquet, Xavier [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Rousseau, Guillaume [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Reynolds, Kevin H. [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2016-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 19, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. The CIDAS detects gammas with a Geiger-Muller tube and the Rocky Flats detects neutrons via charged particles produced in a thin 6LiF disc depositing energy in a Si solid state detector. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  20. Neutron Activation Foil and Thermoluminescent Dosimeter Responses to a Lead Reflected Pulse of the CEA Valduc SILENE Critical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Isbell, Kimberly McMahan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Yi-kang [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Gagnier, Emmanuel [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Authier, Nicolas [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Piot, Jerome [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Jacquet, Xavier [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Rousseau, Guillaume [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Reynolds, Kevin H. [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2016-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 13, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. The CIDAS detects gammas with a Geiger-Muller tube, and the Rocky Flats detects neutrons via charged particles produced in a thin 6LiF disc, depositing energy in a Si solid-state detector. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  1. Neutron Activation and Thermoluminescent Detector Responses to a Bare Pulse of the CEA Valduc SILENE Critical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [ORNL; Isbell, Kimberly McMahan [ORNL; Lee, Yi-kang [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette; Gagnier, Emmanuel [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette; Authier, Nicolas [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille; Piot, Jerome [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille; Jacquet, Xavier [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille; Rousseau, Guillaume [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille; Reynolds, Kevin H. [Y-12 National Security Complex

    2016-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 11, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  2. Neutron Activation Foil and Thermoluminescent Dosimeter Responses to a Polyethylene Reflected Pulse of the CEA Valduc SILENE Critical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McMahan, Kimberly L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Yi-kang [French Atomic Energy Commission (CEA), Saclay (France); Gagnier, Emmanuel [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette; Authier, Nicolas [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Piot, Jerome [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Jacquet, Xavier [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Rousseau, Guillaume [French Atomic Energy Commission (CEA), Salives (France). Valduc Centre for Nuclear Studies; Reynolds, Kevin H. [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2016-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 19, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. The CIDAS detects gammas with a Geiger-Muller tube and the Rocky Flats detects neutrons via charged particles produced in a thin 6LiF disc depositing energy in a Si solid state detector. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  3. TIMP-1 and CEA as biomarkers in third-line treatment with irinotecan and cetuximab for metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Spindler, Karen-Lise Garm; Christensen, Ib Jarle; Nielsen, Hans Jørgen

    2015-01-01

    , the median progression-free survival (PFS) in patients with a high level of TIMP-1 was 2.4 months (95 % CI 2.1-4.1) compared to 3.3 months (95 % CI 2.1-6.2) and 4.7 months (95 % 3.2-7.6) in patients with intermediate or low levels, respectively. Analysis of TIMP-1 as a continuous variable revealed a shorter...... PFS associated with increasing levels of TIMP-1 (hazard ratio (HR) 1.36). These results translated into a significantly lower overall survival (OS) in patients with a high baseline TIMP-1 level (4.5 months (95 % CI 3.4-5.4)), compared to those with intermediate or low TIMP-1 levels (7.8 months (95...... localisation) or to differences in PFS or OS. The rank correlation between CEA and TIMP-1 was r = 0.50, and a test for interaction between TIMP-1 and CEA (dichotomised at 5 ng/ml) in survival analysis was not significant (p = 0.18). A multivariate analysis for PFS and OS resulted in a model with significant...

  4. Superar la frontera: mecanismos de integración territorial entre el Cea y el Pisuerga en el siglo X

    Directory of Open Access Journals (Sweden)

    Carvajal Castro, Álvaro

    2012-12-01

    Full Text Available The different territorial structures that developed in the region between the Cea and the Pisuerga rivers during the 10th century were the outcome of particular processes in the production of space. The study of their formalization within the astur-leonese institutional framework will help us to analyze the political resources and mechanisms employed by both the monarchy and the main regional elites in order to strengthen their power. Ultimately, it will help us to get a better understanding of the processes of territorial integration that took place as the astur-leonese kingdom expanded over the Duero plateau during the Early Middle Ages.

    Las diferentes estructuras territoriales que se desarrollaron entre el Cea y el Pisuerga en el siglo X fueron fruto de procesos de producción del espacio particulares. El estudio de su formalización en el marco institucional asturleonés nos ayudará a analizar los recursos y mecanismos políticos empleados por la monarquía y los poderes territoriales principales para consolidar su poder. En último término, nos permitirá comprender mejor los procesos de integración territorial que tuvieron lugar como consecuencia de la expansión de la monarquía asturleonesa sobre la Meseta del Duero en la Alta Edad Media.

  5. Serum CA-15.3 and CEA patterns in postsurgical follow-up, and in monitoring clinical course of metastatic cancer in patients with breast carcinoma.

    Science.gov (United States)

    al-Jarallah, M A; Behbehani, A E; el-Nass, S A; Temim, L; Ebraheem, A K; Ali, M A; Szymendera, J J

    1993-02-01

    Serum CA-15.3 and CEA levels were longitudinally determined in 307 patients with breast carcinoma during postsurgical follow-up and/or therapy. Of 120 patients with no apparent disease, the specificity of marker levels fluctuating within the normal range (true-negative) was 98% for CA-15.3 alone (P = 0.004) and about 88% for CEA alone or for the tests combined. However, the false-negative levels in patients with progressive cancer reduced the predictive value of the tandem to around 76%, i.e. normal levels of both markers correctly predicted uneventful postsurgical course in only three fourths of the patients. Of 187 patients with active disease, the sensitivity of raised or increasing marker levels was around 70% for CA-15.3 alone or CEA alone, and 82% for the tests combined (P = 0.006). The 11% false-positive rate of CEA in patients with no apparent disease decreased the predictive value of a positive test from 98% for CA-15.3 alone (P = 0.006) to 91% for CEA alone or the tandem. Serum CA-15.3 or CEA paralleled the site of relapse: at least one marker was found elevated in 60% of patients with locoregional disease or with metastases to the lungs or bones exclusively, and in 90% of those with metastases to the lungs and bones or to the liver. A concurrent decrease of both marker levels reflected response to therapy while an increase of at least one marker level reflected treatment failure. It may be concluded that the marker tandem was better than either marker alone for follow-up aimed at detection of relapse, and that the tests were approximately 80% accurate for follow-up and/or monitoring therapy.

  6. Clinical significance of detecting CEA, CA199, AFP, HCG, CA153, CA125 in postoperative treatment of patients with ovarian cancer

    Institute of Scientific and Technical Information of China (English)

    Xue Pan; Zhen-Hua Du

    2016-01-01

    Objective:To explore the clinical significance of carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), a tire protein (AFP), human chorionic gonadotropin (HCG), carbohydrate antigen 153 (CA153) and carbohydrate antigen 125 (CA125) in the postoperative treatment of patients with ovarian cancer.Methods:210 cases of patients with ovarian cancer after initial treatment from January 2015 to December 2015, 232 cases of patients with ovarian benign tumor and 250 cases of healthy women were selected, CEA, CA199, AFP, HCG, CA153 and CA125 levels were detected, and the levels after chemotherapy in patients with ovarian carcinoma were detected.Results:CEA, CA199, AFP, HCG, CA153 and CA125 levels in patients with ovarian cancer were (12.37±7.43) ng/mL, (84.04±26.96) U/mL, (37.46±9.47) μg/L, (110.54±35.51) IU/L, (51.23±9.20) U/mL and (64.36±42.68) U/mL, respectively, which were significantly higher than that in normal controls and patients with benign ovarian lesions, and were considered to be statistically significant. Chemotherapy after two cycles, CEA, CA199, AFP, HCG, CA153 and CA125 levels in patients with ovarian cancer were significantly lower than that before chemotherapy, and were considered to be statistically different. Chemotherapy after four cycles, CEA, CA199, AFP, HCG, CA153 and CA125 levels in patients with ovarian cancer continue to decrease, and were significantly lower than that of chemotherapy after two cycles, and had statistical differences.Conclusion:CEA, CA199, AFP, HCG, CA153 and CA125 can be used as important indicators for monitoring the chemotherapy effects, early recurrence and metastasis of ovarian cancer.

  7. Value of {sup 18}F-FDG uptake on PET/CT and CEA level to predict epidermal growth factor receptor mutations in pulmonary adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Kai-Hsiung; Hsu, Hsian-He; Chang, Wei-Chou; Hsu, Yi-Chih; Chang, Tsun-Hou [Tri-Service General Hospital and National Defense Medical Center, Department of Radiology, Taipei 114 (China); Huang, Tsai-Wang; Chang, Hung [Tri-Service General Hospital and National Defense Medical Center, Department of Thoracic Surgery, Taipei (China); Gao, Hong-Wei [Tri-Service General Hospital and National Defense Medical Center, Department of Pathology, Taipei (China); Shen, Daniel H.Y. [Tri-Service General Hospital and National Defense Medical Center, Department of Nuclear medicine, Taipei (China); Chu, Chi-Ming [Institute of Public Health, National Defense Medical Center and University, Section of Health Informatics, Taipei (China); Ho, Ching-Liang [Tri-Service General Hospital and National Defense Medical Center, Division of Hematology-Oncology, Department of Internal Medicine, Taipei (China)

    2014-10-15

    The identification of the mutation status of the epidermal growth factor receptor (EGFR) is important for the optimization of treatment in patients with pulmonary adenocarcinoma. The acquisition of adequate tissues for EGFR mutational analysis is sometimes not feasible, especially in advanced-stage patients. The aim of this study was to predict EGFR mutation status in patients with pulmonary adenocarcinoma based on {sup 18}F-fluorodeoxyglucose (FDG) uptake and imaging features in positron emission tomography/computed tomography (PET/CT), as well as on the serum carcinoembryonic antigen (CEA) level. We retrospectively reviewed 132 pulmonary adenocarcinoma patients who underwent EGFR mutation testing, pretreatment FDG PET/CT and serum CEA analysis. The associations between EGFR mutations and patient characteristics, maximal standard uptake value (SUVmax) of primary tumors, serum CEA level and CT imaging features were analyzed. Receiver-operating characteristic (ROC) curve analysis was performed to quantify the predictive value of these factors. EGFR mutations were identified in 69 patients (52.2 %). Patients with SUVmax ≥6 (p = 0.002) and CEA level ≥5 (p = 0.013) were more likely to have EGFR mutations. The CT characteristics of larger tumors (≥3 cm) (p = 0.023) and tumors with a nonspiculated margin (p = 0.026) were also associated with EGFR mutations. Multivariate analysis showed that higher SUVmax and CEA level, never smoking and a nonspiculated tumor margin were the most significant predictors of EGFR mutation. The combined use of these four criteria yielded a higher area under the ROC curve (0.82), suggesting a good discrimination. The combined evaluation of FDG uptake, CEA level, smoking status and tumor margins may be helpful in predicting EGFR mutation status in patients with pulmonary adenocarcinoma, especially when the tumor sample is inadequate for genetic analysis or genetic testing is not available. Further large-scale prospective studies are

  8. INIS - International Nuclear Information System. CEA-users relations. Nuclear information in total freedom; INIS - International Nuclear Information System. Relations CEA utilisateurs. L'information nucleaire en toute liberte

    Energy Technology Data Exchange (ETDEWEB)

    Surmont, J.; Paillard, M.D.; Constant, A.; Guille, N.; Le Blanc, A.; Mouffron, O.; Anguise, P.; Jouve, J.J.; Lilin, A

    2009-07-01

    This poster, prepared for the seventh edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents the principle of operation of the INIS system, based on a cooperative and decentralized preparation of the data which are centralized by the IAEA for the preparation of the INIS products: the database (on Internet and on CD/DVD-Rom), the collection of grey literature documents in full text (microfiches and CD/DVD-roms), and the multilingual thesaurus available in 7 different languages and under various formats. The poster presents these different products, and the role of the INIS members in the distribution of these products towards their national users. One insert presents the French INIS team of the CEA-Saclay and its daily work. (J.S.)

  9. Pharmacokinetics and Dosimetry Studies for Optimization of Pretargeted Radioimmunotherapy in CEA-Expressing Advanced Lung Cancer Patients

    Directory of Open Access Journals (Sweden)

    Caroline eBodet-Milin

    2015-11-01

    Full Text Available Objectives. A phase I pretargeted radioimmunotherapy trial (EudractCT 200800603096 was designed in patients with metastatic lung cancer expressing carcinoembryonic antigen (CEA to optimize bispecific antibody and labelled peptide doses, as well as the delay between their injections.Methods. Three cohorts of 3 patients received the anti-CEA x anti-histamine-succinyl-glycine (HSG humanized trivalent bispecific antibody (TF2 and the IMP288 bivalent HSG-peptide. Patients underwent a pre-therapeutic imaging session S1 (44 or 88 nmol/m2 of TF2 followed by 4.4 nmol/m2, 185 MBq, of 111In-labelled IMP288, and, 1-2 weeks later, a therapy session S2 (240 or 480 nmol/m2 of TF2 followed by 24 nmol/m2, 1.1 GBq/m2, 177Lu-labeled IMP288. The pretargeting delay was 24 or 48 hours. The dose schedule was defined based on pre-clinical TF2 pharmacokinetic studies, on our previous clinical data using the previous anti-CEA pretargeting system and on clinical results observed in the first patients injected using the same system in the Netherlands.Results. TF2 pharmacokinetics (PK was represented by a two-compartment model in which the central compartment volume was linearly dependent on the patient's surface area. PK were remarkably similar, with a clearance of 0.33 +/- 0.03 L/h per m2. 111In- and 177Lu-IMP288 PK were also well represented by a two-compartment model. IMP288 PK were faster (clearance 1.4 to 3.3 l/h. The central compartment volume was proportional to body surface area and IMP288clearance depended on the molar ratio of injected IMP288 to circulating TF2 at the time of IMP288 injection. Modelling of image quantification confirmed the dependence of IMP288 kinetics on circulating TF2, but tumour activity PK were variable. Organ absorbed doses were not significantly different in the 3 cohorts, but the tumour dose was significantly higher with the higher molar doses of TF2 (p < 0.002. S1 imaging predicted absorbed doses calculated in S2. Conclusion. The best

  10. Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA Gold 4 epitope and designed for radioimmunotherapy (RIT of colorectal cancers

    Directory of Open Access Journals (Sweden)

    Pugnière Martine

    2004-10-01

    Full Text Available Abstract Background Human monoclonal antibodies (MAbs are needed for colon cancer radioimmunotherapy (RIT to allow for repeated injections. Carcinoembryonic antigen (CEA being the reference antigen for immunotargeting of these tumors, we developed human anti-CEA MAbs. Methods XenoMouse®-G2 animals were immunized with CEA. Among all the antibodies produced, two of them, VG-IgG2κ and VG-IgM, were selected for characterization in vitro in comparison with the human-mouse chimeric anti-CEA MAb X4 using flow cytometry, surface plasmon resonance, and binding to radiolabeled soluble CEA and in vivo in human colon carcinoma LS174T bearing nude mice. Results Flow cytometry analysis demonstrated binding of MAbs on CEA-expressing cells without any binding on NCA-expressing human granulocytes. In a competitive binding assay using five reference MAbs, directed against the five Gold CEA epitopes, VG-IgG2κ and VG-IgM were shown to be directed against the Gold 4 epitope. The affinities of purified VG-IgG2κ and VG-IgM were determined to be 0.19 ± 0.06 × 108 M-1 and 1.30 ± 0.06 × 108 M-1, respectively, as compared with 0.61 ± 0.05 × 108 M-1 for the reference MAb X4. In a soluble phase assay, the binding capacities of VG-IgG2κ and VG-IgM to soluble CEA were clearly lower than that of the control chimeric MAb X4. A human MAb concentration of about 10-7 M was needed to precipitate approximatively 1 ng 125I-rhCEA as compared with 10-9 M for MAb X4, suggesting a preferential binding of the human MAbs to solid phase CEA. In vivo, 24 h post-injection, 125I-VG-IgG2κ demonstrated a high tumor uptake (25.4 ± 7.3%ID/g, close to that of 131I-X4 (21.7 ± 7.2%ID/g. At 72 h post-injection, 125I-VG-IgG2κ was still concentrated in the tumor (28.4 ± 11.0%ID/g whereas the tumor concentration of 131I-X4 was significantly reduced (12.5 ± 4.8%ID/g. At no time after injection was there any accumulation of the radiolabeled MAbs in normal tissues. A pertinent analysis of

  11. Assessment of biological variation and analytical imprecision of CA 125, CEA, and TPA in relation to monitoring of ovarian cancer

    DEFF Research Database (Denmark)

    Tuxen, M K; Sölétormos, G; Petersen, P H

    1999-01-01

    biological variation. The aim of the study was to assess (i) the analytical imprecision (CVA) and the average inherent intra- and interindividual biological variation (CVTI and CVG, respectively) for CA 125, CEA, and TPA in a group of healthy women; (ii) the significance of changes in serial results of each...... marker; and (iii) the index of individuality. METHODS: The study group consisted of 31 healthy women. Sixteen blood samples from each subject were collected in four series over a period of approximately 1 year. Data analysis was based on ANOVA. The index of individuality was calculated as ((CV2A + CV2TI......)/CV2G)1/2 and the critical difference for a change between two consecutive concentrations as radical2xZx(CV2P + CV2A + CV2TI)1/2 (Z = 1.65 for unidirectional and 1.96 for bidirectional changes, P

  12. Origin and evolution of cultivated cucurbits Origem e evolução de cucurbitáceas cultivadas

    Directory of Open Access Journals (Sweden)

    Dilson Antônio Bisognin

    2002-08-01

    Full Text Available Cucurbits (Cucurbitaceae are among the most important plant families supplying humans with edible products and useful fibers. Plants of this family are very similar in above ground development, but they have high genetic diversity for fruit shape and other fruit characteristics, resulting in a variety of uses. The objective of this review was to discuss the origin and evolution of the most important cultivated cucurbits. Understanding the evolutionary history and domestication process increase the possibility for better exploiting the genetic diversity for cultivar development. The domestication selection in cucurbits was for shape, less bitter flesh, larger and fewer seeds, and larger fruit size, resulting in high genetic diversity within and among cultivated species. This variation can be associated with the wide range of uses that require different shape, size and a constant ratio between fruit length and fruit diameter. The discussion of the breeding history indicates how artificial selection could speed up changes in fruit characteristics to attend specific uses and increase adaptation to a variety of environmental conditions in which cucurbits are growing worldwide. Although interspecific hybridization has been employed in cucurbit breeding more than in any other family, there is still a high potential for increasing its application for germplasm and cultivar development.As cucurbitáceas (Cucurbitaceae são uma das mais importantes famílias de plantas utilizadas para produção de alimentos e fibras. Apesar de a parte aérea das plantas desta família ser muito similar em seu desenvolvimento, grande variabilidade genética tem sido mantida para formato e outras características de fruto, o que aumenta o seu potencial de uso. O objetivo desta revisão foi discutir a origem e a evolução das cucurbitáceas cultivadas. A história da evolução e o conhecimento das alterações ocorridas durante este processo podem facilitar a utiliza

  13. Pre-clinical evaluation of a novel CEA-targeting near-infrared fluorescent tracer delineating colorectal and pancreatic tumors

    Science.gov (United States)

    Boonstra, Martin C.; Tolner, Berend; Schaafsma, Boudewijn E.; Boogerd, Leonora S.F.; Prevoo, Hendrica A.J.M; Bhavsar, Guarav; Kuppen, Peter J.K.; Sier, Cornelis F.M.; Bonsing, Bert A.; Frangioni, John V.; van de Velde, Cornelis J.H.; Chester, Kerry A.; Vahrmeijer, Alexander L.

    2016-01-01

    Surgery is the cornerstone of oncologic therapy with curative intent. However, identification of tumor cells in the resection margins is difficult, resulting in non-radical resections, increased cancer recurrence and subsequent decreased patient survival. Novel imaging techniques that aid in demarcating tumor margins during surgery are needed. Overexpression of carcinoembryonic antigen (CEA) is found in the majority of gastro-intestinal carcinomas, including colorectal and pancreas. We developed ssSM3E/800CW, a novel CEA-targeted near-infrared fluorescent (NIRF) tracer, based on a disulphide stabilized single-chain antibody fragment (ssScFv), to visualize colorectal and pancreatic tumors in a clinically translatable setting. The applicability of the tracer was tested for cell and tissue binding characteristics and dosing using immunohistochemistry, flow cytometry, cell-based plate assays and orthotopic colorectal (HT-29, well differentiated) and pancreatic (BXPC-3, poorly differentiated) xenogeneic human-mouse models. NIRF signals were visualized using the clinically compatible FLARE™ imaging system. Calculated clinically relevant doses of ssSM3E/800CW selectively accumulated in colorectal and pancreatic tumors/cells, with highest tumor-to-background ratios of 5.1±0.6 at 72 h post-injection, which proved suitable for intra-operative detection and delineation of tumor boarders and small (residual) tumor-nodules in mice, between 8 h and 96 h post-injection. Ex vivo fluorescence imaging and pathologic examination confirmed tumor-specificity and the distribution of the tracer. Our results indicate that ssSM3E/800CW shows promise as a diagnostic tool to recognize colorectal and pancreatic cancers for fluorescent-guided surgery applications. If successful translated clinically, this tracer could help improve the completeness of surgery and thus survival. PMID:25895046

  14. Neutron Activation Foil and Thermoluminescent Dosimeter Responses to a Lead Reflected Pulse of the CEA Valduc SILENE Critical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Isbell, Kimberly McMahan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Yi-kang [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Gagnier, Emmanuel [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Authier, Nicolas [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Piot, Jerome [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Jacquet, Xavier [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Rousseau, Guillaume [Commissariat a l' Energie Atomique et aux Energies Alternatives (CEA-Saclay), Gif-sur-Yvette (France); Reynolds, Kevin H. [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2016-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 13, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. The CIDAS detects gammas with a Geiger-Muller tube, and the Rocky Flats detects neutrons via charged particles produced in a thin 6LiF disc, depositing energy in a Si solid-state detector. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  15. Concordance of Hypermethylated DNA and the Tumor Markers CA 15-3, CEA, and TPA in Serum during Monitoring of Patients with Advanced Breast Cancer

    DEFF Research Database (Denmark)

    Kristiansen, Søren; Jørgensen, Lars Mønster; Høgh Hansen, Morten

    2015-01-01

    The serological protein tumor markers CA 15-3, CEA, and TPA are frequently used to monitor tumor burden among metastatic breast cancer patients. Breast cancer is associated with global DNA hypomethylation and hypermethylation of some promoter regions. No monitoring study has yet investigated the ...

  16. Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals

    DEFF Research Database (Denmark)

    Nielsen, Hans J; Brünner, Nils; Olsen, Jesper;

    2011-01-01

    Objective. The combination of plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) and carcinoembryonic antigen (CEA) may be valuable biomarkers for early detection of colorectal cancer (CRC). A prospective, population based study was performed to validate this hypothesis. Material and method...

  17. Las loganiáceas (Loganiaceæ de Cuba

    Directory of Open Access Journals (Sweden)

    Fernández Casas, F. J.

    1998-12-01

    Full Text Available Monographic revisión of the Loganiíaceæ of Cuba. It includes five genera, eight native species (two endemics and four introduced ones. For each species. after the nomenclature, description, hábitat and distribution, sorne data about dispersion and phenology are recorded, and sometimes ethnobotanical and chemical composition data. When found, karyologic information was a150 included. The chorological data are completed with eight maps showing the Cuban distribution of as many wild taxa. Further more, nine plates representing as many species are included, plus five indices. The first index shows the distributional maps. The second one shows the illustrations. The third one shows the 411 collections. The fourth one shows the common names. The fifth, which has 77 entries, shows all scientific names used, both the accepted ones and the synonyms.

    [es] Revisión monográfica de las loganiáceas de la flora de Cuba. Comprende cinco géneros con ocho especies endémicas (dos endemismos, más cuatro especies exóticas. Para cada especie y tras la nomenclatura, además de la descripción, el hábitat y la distribución, se consignan diversos datos sobre dispersión y fenología, más algunos etnobotánicos o de composición química ocasionalmente. Cuando pudimos hallarla, incl uimos información cariológica. Los datos corológicos se completan con ocho mapas que muestran la distribución cubana de otros tantos táxones nativos de Cuba. Acompañan al texto nueve láminas que representan otras tantas especies, más cinco índices, En el primero se encuentran los ocho mapas distribucionales. En el segundo las nueve ilustraciones. El tercero las 411 colecciones. En el cuarto los nombres vulgares. En el quinto figuran los 77 nombres científicos empleados, tanto aceptados como sinónimos, o confusiones. Un apéndice final, con cinco fotografías, reúne información diversa sobre tipos nomenclaturales. [ru] Моног

  18. Clinical Significance and Prognostic Value of CA72-4 Compared with CEA and CA19-9 in Patients with Gastric Cancer

    Directory of Open Access Journals (Sweden)

    M. Ychou

    2000-01-01

    Full Text Available Carcinoembryonic antigen (CEA and CA 19-9 are both widely used in the follow up of patients with gastrointestinal cancer. More recently another tumor marker, named CA 72-4 has been identified and characterized using two different monoclonal antibodies B72.3 and CC49. Several reports evaluated CA 72-4 as a serum tumor marker for gastric cancer and compared its clinical utility with that of CEA or CA 19-9; few reports concerned its prognostic value. In the present study, CA 72-4 is evaluated and compared with CEA and CA 19-9 in various populations of patients with gastric cancer and benign disease; for 52 patients with gastric adenocarcinoma and 57 patients without neoplastic disease CEA, CA 19-9 and CA 72-4 were evaluated before treatment. Sensitivity of the tumor markers CA 72-4, CA 19-9 and CEA at the recommended cut-off level in all 52 patients were 58%, 50% the sensitivity increased to 75%. of these markers, for non metastatic patients, multivariate analyses indicated that none of the markers were significant, when adjusted for gender and age (which were indicators of poor prognosis; patients with abnormal values of CA72-4 tended to have shorter survival than patients with normal values (p < 0.07. In the metastatic population, only high values of CA19-9 (p < 0.02 and gender (women (p < 0.03 were indicators of poor prognosis in univariate analysis; multivariate analysis revealed that both CA72-4 (p = 0.034 and CA19-9 p = 0.009, adjusted for gender were independent prognostic factors. However, CA72-4 lost significance (p = 0.41 when adjusted for CA19-9 and gender, indicating that CA19-9 provides more prognostic information than CA72-4.

  19. Gestión del conocimiento y comunidades de práctica en laboratorios de investigación del Polo Científico Grenoblés en Francia

    Directory of Open Access Journals (Sweden)

    Margarita María Gaviria Velásquez

    2008-07-01

    Full Text Available Se analizan algunas de las prácticas relacionadas con la gestión del conocimiento en los laboratoriosdel Polo de Investigación Científica ubicado en la ciudad de Grenoble (Francia. El polo científicogrenoblés se construye a partir del acentuado desarrollo científico e industrial que vive la región desdefinales del siglo XIX, ligado a un largo proceso de producción académica, y de compromiso económicoy estatal; denso en generación de nuevos conocimientos. Es también un modelo de trabajo colectivo,en el cual cooperan varias ciudades y países. La pregunta fundamental de la investigación es si,efectivamente, en este contexto se puede hablar de la presencia de un modelo de gestión del conocimientoy cuáles serían las condiciones para que esto se de. El análisis se ocupa específicamente delestudio del modelo Nonaka llamado «Ba» (conocimiento situado que estudia el proceso de conversiónde conocimientos tácitos en explícitos en los laboratorios de investigación y si éstos funcionancomo comunidades de práctica. Los datos que sustentan este trabajo fueron construidos a partir deentrevistas, análisis de componentes principales, observaciones sobre el terreno y el análisis deestudio de caso.

  20. Digitization and valorization through the INIS database of an exceptional stock of grey literature documents: the 'historical' CEA reports (1948-1969); Numerisation et valorisation au travers de la base INIS d'un fonds documentaires exceptionnel de litterature grise: les rapports 'historiques' du CEA (1948-1969)

    Energy Technology Data Exchange (ETDEWEB)

    Surmont, J.; Brulet, C.; Brulet, M.; Pourny, M.; Constant, A.; Guille, N.; Le Blanc, A.; Mouffron, O.; Anguise, P.; Jouve, J.J

    2008-07-01

    This poster, prepared for the sixth edition of the meetings of scientific and technical information professionals (RPIST, Nancy (France)), presents the joint CEA/IAEA project of digitization of the collection of reports published by the French atomic energy commission (CEA) between 1948 and 1969. This exceptional stock of about 2760 grey literature monographs covers the first 20 years of researches carried out at the CEA and has been entered in the INIS database with a link to the full text. The poster describes the different steps of the project from the selection of the documents, their digitization, and the preparation of the corresponding inputs. The INIS database and its general content are briefly presented. (J.S.)

  1. Special document: which energies for tomorrow? Fossil, renewable, nuclear, hydrogen energies; the CEA of Saclay at the heart of the research; energy, greenhouse effect, climate; Dossier special: quelles energies pour demain? Energies fossiles, renouvelables, nucleaires, hydrogene; le Centre CEA de Saclay au coeur de la recherche; energie, effet de serre, climat

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2003-04-01

    The Cea devotes many research programs in the energy domain and especially in the development of new energetic solutions: hydrogen program, photovoltaic program, energy conservation domain and improvement of energy production systems. In this framework, this document presents synthetical information on the France situation in the world energy space and on the Cea Saclay researches. The energy policy and the electric power in France, the fossil energies, the nuclear energy, the renewable energies, the hydrogen and the fuel cell, the greenhouse effect and the climatology are detailed. (A.L.B.)

  2. Efeito da cobertura viva com leguminosas herbáceas perenes na agregação de um argissolo

    Directory of Open Access Journals (Sweden)

    A. Perin

    2002-09-01

    Full Text Available O presente trabalho foi desenvolvido na área do Campo Experimental da Embrapa Agrobiologia, Seropédica (RJ, com o objetivo de avaliar a morfologia e a distribuição de raízes de algumas leguminosas herbáceas perenes; os efeitos da cobertura viva no teor de carbono orgânico, e a agregação de um Argissolo Vermelho-Amarelo distrófico, medida pela estabilidade dos agregados em água. O delineamento experimental adotado foi o de blocos casualizados, com três repetições. Os tratamentos consistiram de três diferentes espécies de leguminosas herbáceas perenes e um tratamento-controle sem cobertura viva (capinado. As leguminosas utilizadas foram amendoim forrageiro (Arachis pintoi, cudzu tropical(Pueraria phaseoloides e siratro (Macroptilium Atropurpureum. Para a estabilidade de agregados, as profundidades de amostragem foram 0-5 e 5-10 cm, enquanto, para a morfologia e distribuição radicular, as avaliações consistiram das profundidades 0-5, 5-10, 10-20 e 20-40 cm. As coberturas com as leguminosas amendoim forrageiro e cudzu tropical propiciaram os maiores valores percentuais na classe de agregados > 2,00 mm, em média 38 % superiores aos obtidos na área capinada. Os valores do diâmetro médio ponderado (DMP dos agregados no solo com cobertura de leguminosas foram superiores aos da área capinada para ambas as camadas, o que demonstra o efeito favorável das coberturas vivas na estabilização dos agregados do solo. A cobertura viva de amendoim forrageiro proporcionou incremento no teor de carbono orgânico no solo. Quanto aos atributos morfológicos das raízes, verificou-se que o amendoim forrageiro apresentou raio radicular intermediário entre as demais espécies e área e massa radicular maiores, o que auxiliou na interpretação do efeito positivo da cobertura viva com essa espécie na agregação do solo.

  3. Expression and clinical significance of CEA-mRNA, CK20-mRNA in peripheral blood of esophageal cancer patients%食管癌患者外周血CEA-mRNA、CK20-mRNA的表达及意义

    Institute of Scientific and Technical Information of China (English)

    金文波; 周乃康; 郑梦利; 祁彦君; 马连君

    2009-01-01

    目的 以CEA-mRNA、CK20-mRNA为靶基因,应用逆转录聚合酶链反应(RT-PCR)的方法,检测食管癌患者肿瘤组织以及食管癌患者外周血微转移,探寻靶基因作为食管癌微转移检测的分子标志物的可行性.方法 应用RT-PCR技术检测53例食管癌组织中CEA-mRNA、CK20-mRNA的表达;检测53例食管癌患者外周血中靶基因的表达,并以10例良性食管疾病患者和20名健康人外周血作为对照.结果 53例食管癌患者病理组织中CEA-mRNA、CK20-mRNA的表达率为96.23%(51/53)、100%(53/53),外周血中CEA-mRNA、CK20-mRNA表达阳性率为52.83%(28/53)、49.06%(26/53);对照组中,10例食管良性病变患者和20名健康人外周血中均有1例CEA-mRNA表达、无CK20-mRNA表达.结论 CEA-mRNA、CK20-mRNA是检测食管癌组织及食管癌外周血微转移良好的分子标志物,两者表达与食管癌TNM分期关系密切.%Objective To establish reverse transcriptase-polymerase chain reaction(RT-PCR) with primers specific for CEA gene and CK20 gene to detect circulating tumor cells in peripheral blood of esophageal cancer pa-tients,and try to find the relationship between the mRNA expression and micrometastasis. Methods The expressions of CEA,CK20 were analyzed by RT-PCR in 53 cases of esophageal tumor tissue and in peripheral blood,compared with 10 patients with benign esophageal disease and 20 healthy volunteers. Results The expressions of CEA-mRNA, CK20-mRNA were 96.23% (51/53), 100% ( 53/53 ) in 53 esophageal tumor tissue and were 52.83% (28/53), 49.06% (26/53) in peripheral blood of 53 esophageal cancer patients. In control group,there was only one expression of CEA-mRNA in peripheral blood of 10 patients with benign esophageal disease,as well as in 20 healthy volunteers. There was no expression of CK20-mRNA in peripheral blood of 10 patients with benign esophageal disease and 20 healthy volunteers. Conclusion CEA-mRNA, CK20-mRNA might be specific and sensitive markers to detect

  4. EURATOM-CEA association contributions to the 26. EPS conference on controlled fusion and plasma physics, Maastricht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-10-15

    This report references the EURATOM-CEA association contributions presented at the 26. EPS conference on controlled fusion and plasma physics, in Maastricht (Netherlands) the 14-18 June 1999. Two invited papers and 24 contributed papers are proposed. They deal with: tokamak devices; particle recirculation in ergodic divertor; current profile control and MHD stability in Tore Supra discharges; edge-plasma control by the ergodic divertor; electron heat transport in stochastic magnetic layer; bolometry and radiated power; particle collection by ergodic divertor; study and simulation of pa impurities; line shape modelling for plasma edge conditions; dynamical study of the radial structure of the fluctuations measured by reciprocating Langmuir probe in Tore Supra; up-down asymmetry of density fluctuations; Halo currents in a circular tokamak; real time measurement of the position, density, profile and current profile at Tore Supra; poloidal rotation measurement by reflectometry; interpretation of q-profile dependence of the LH power deposition profile during LHCD experiments; ICFR plasma production and optimization; improved core electron confinement; measurement of hard X-ray emission profile; modelling of shear effects on thermal and particles transport; ion turbulence; current drive generation based on autoresonance and intermittent trapping mechanisms. (A.L.B.)

  5. Principais doenças de Anonáceas no Brasil: descrição e controle

    Directory of Open Access Journals (Sweden)

    Nilton Tadeu Vilela Junqueira

    2014-01-01

    Full Text Available Várias doenças podem afetar folhas, caules, flores e frutos de gravioleira, pinheira e atemoia em diferentes estádios de seus desenvolvimentos. Geralmente, as doenças mais importantes são causadas por fungos durante o florescimento e a frutificação. Também podem ocorrer murchas ou podridões de raízes, causadas por nematoides e patógenos do solo. A antracnose (Colletotrichum gloeosporioides, murcha ou podridões de raízes (Rhizoctonia solani, Cylindrocladium clavatum, Phytophthora sp., Pythium sp., Phytophthora nicotianae var. parasitica, cancros (Albonectria rigidiuscula e podridão de frutos (Botryodiplodia theobromae, sin. Lasiodiplodia theobromae são as mais importantes. Por outro lado, a podridão-parda-do-fruto (Rhizopus stolonifer provoca perdas expressivas na produção de graviola. A seguir, são descritas as principais doenças que afetam estas espécies de anonáceas, seus agentes causais e as medidas de controle.

  6. IDENTIFICACIÓN DE Thrips palmi Karny (THYSANOPTERA: THRIPIDAE EN CULTIVOS DE CUCURBITÁCEAS EN PANAMÁ

    Directory of Open Access Journals (Sweden)

    Jos\\u00E9 \\u00C1ngel Herrera-V\\u00E1squez

    2013-01-01

    Full Text Available El objetivo de este trabajo fue la identificación morfológica y molecular de T. palmi en cultivos de cucurbitáceas en Panamá. Los especímenes fueron colectados en las provincias de Los Santos, Herrera, Coclé, Veraguas y Chiriquí, del 17 de febrero de 2009 al 17 de agosto de 2010. La identificación de los insectos fue realizada en el Laboratorio de Protección Vegetal (LPV, del Centro de Investigación Agropecuaria Central (CIAC, del Instituto de Investigación Agropecuaria de Panamá (IDIAP, ubicado en Los Canelos, distrito de Santa María, provincia de Herrera, Panamá. Los especímenes fueron identificados mediante morfología utilizando claves taxonómicas. Se utilizó la reacción en cadena de la polimerasa (PCR con cebadores específicos de T. palmi, los cuales amplifican el gen mitocondrial de la citocromo oxidasa subunidad I (mtCOI. Se obtuvieron amplicones (productos de PCR del tamaño esperado (220-pb correspondientes a T. palmi. Adicionalmente, un producto amplificado fue purificado y secuenciado. Para verificar la identidad del insecto, la secuencia obtenida fue analizada con ayuda del Instrumento de Búsqueda de Alineamientos Locales Básicos (BLAST y comparada con secuencias de referencia del Centro Nacional para la Información Biotecnológica (NCBI.

  7. Review of nuclear data improvement needs for nuclear radiation measurement techniques used at the CEA experimental reactor facilities

    Directory of Open Access Journals (Sweden)

    Destouches Christophe

    2016-01-01

    Full Text Available The constant improvement of the neutron and gamma calculation codes used in experimental nuclear reactors goes hand in hand with that of the associated nuclear data libraries. The validation of these calculation schemes always requires the confrontation with integral experiments performed in experimental reactors to be completed. Nuclear data of interest, straight as cross sections, or elaborated ones such as reactivity, are always derived from a reaction rate measurement which is the only measurable parameter in a nuclear sensor. So, in order to derive physical parameters from the electric signal of the sensor, one needs specific nuclear data libraries. This paper presents successively the main features of the measurement techniques used in the CEA experimental reactor facilities for the on-line and offline neutron/gamma flux characterizations: reactor dosimetry, neutron flux measurements with miniature fission chambers and Self Power Neutron Detector (SPND and gamma flux measurements with chamber ionization and TLD. For each technique, the nuclear data necessary for their interpretation will be presented, the main identified needs for improvement identified and an analysis of their impact on the quality of the measurement. Finally, a synthesis of the study will be done.

  8. Development and manufacturing of a Nb$_{3}$Sn quadrupole magnet Model at CEA/Saclay for TESLA Interaction Region

    CERN Document Server

    Durante, Maria; Fratini, M; Leboeuf, D; Segreti, M; Védrine, Pierre; 10.1109/TASC.2004.829129

    2004-01-01

    One possible application of Nb/sub 3/Sn, whose superconducting properties far exceed those of NbTi, is the fabrication of short and powerful quadrupole magnets for the interaction regions of large particle accelerators. In some projects, as in the future linear collider TESLA, the quadrupole magnets are inside the detector solenoid and must operate in its background field. This situation gives singular Lorentz force distribution in the ends of the magnet. To learn about Nb/sub 3/Sn technology, evaluate fabrication techniques and test the interaction with a solenoidal field, DAPNIA /SACM at CEA/Saclay has started the manufacturing of a 1-m-long, 56- mm-single-aperture quadrupole magnet model. The model relies on the same coil geometry as the LHC arc quadrupole magnets, but has no iron yoke. It will produce a nominal field gradient of 211 T/m at 11,870 A. The coils are wound from Rutherford-type cables insulated with glass fiber tape, before being heat-treated and vacuum-impregnated with epoxy resin. Laminated,...

  9. Caracterização físico-química de algumas tuberosas amiláceas

    Directory of Open Access Journals (Sweden)

    Leonel Magali

    2002-01-01

    Full Text Available As principais fontes de amido comercial no mundo são o milho, a batata e a mandioca. Entretanto, nos últimos anos vem crescendo o interesse em amidos naturais que possam ser utilizados pela indústria alimentícia. Assim, este trabalho teve por objetivo caracterizar, quanto à composição físico-química, açafrão, ahipa, araruta, batata-doce, biri, inhame e mandioquinha-salsa, tuberosas amiláceas potencialmente passíveis de introdução como matérias-primas de interesse comercial. Amostras das tuberosas foram analisadas quanto ao teor de umidade, cinzas, proteína, matéria graxa, açúcares redutores e totais, fibras e amido. Os resultados obtidos mostraram que das tuberosas analisadas as que apresentaram maior teor de amido foram a araruta (Maranta arundinacea, o inhame (Dioscorea sp e o biri (Canna edulis, sendo que o inhame e o biri apresentaram também o maior rendimento potencial em toneladas de amido/hectare.

  10. Review of nuclear data improvement needs for nuclear radiation measurement techniques used at the CEA experimental reactor facilities

    Science.gov (United States)

    Destouches, Christophe

    2016-03-01

    The constant improvement of the neutron and gamma calculation codes used in experimental nuclear reactors goes hand in hand with that of the associated nuclear data libraries. The validation of these calculation schemes always requires the confrontation with integral experiments performed in experimental reactors to be completed. Nuclear data of interest, straight as cross sections, or elaborated ones such as reactivity, are always derived from a reaction rate measurement which is the only measurable parameter in a nuclear sensor. So, in order to derive physical parameters from the electric signal of the sensor, one needs specific nuclear data libraries. This paper presents successively the main features of the measurement techniques used in the CEA experimental reactor facilities for the on-line and offline neutron/gamma flux characterizations: reactor dosimetry, neutron flux measurements with miniature fission chambers and Self Power Neutron Detector (SPND) and gamma flux measurements with chamber ionization and TLD. For each technique, the nuclear data necessary for their interpretation will be presented, the main identified needs for improvement identified and an analysis of their impact on the quality of the measurement. Finally, a synthesis of the study will be done.

  11. Transports publics et structuration de l'espace périurbain : méthode d'aide à la décision pour l'implantation d'un tram-train.
    Exemple d'application de Grenoble à Crolles
    (moyenne vallée du Grésivaudan).

    OpenAIRE

    Bouhet, Olivier

    2006-01-01

    Thèse cofinancée par l'ADEME et la Grenoble Alpes Métropole; Presenting the creation of a decision-making method for the development of a tram-train system. The approach suggested here is based on the coupled use of the GIS (Geographic Information System) and of the MCE (Multi criteria evaluation). This approach seeks to define, through the identification of factors and constraints, areas capable of hosting a tram-train system (railway, line, stops, change stations...) on a given territory an...

  12. Effect of radiotherapy on serum SCC, CEA, CRFRA21-1, TAG72, CA199 and lymphocyte subsets in patients with esophageal squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    Sha Sha; Bo Yu; Zhong-Qin Shu; Xiao-Wei Gu; Wei-Dong Mao; Lin-Yun Xia; Jian-Jun Qin

    2016-01-01

    Objective:To study the effect of radiotherapy on serum SCC, CEA, CRFRA21-1, TAG72, CA199 and lymphocyte subsets in patients with esophageal squamous cell carcinoma. Methods: A total of 60 patients with esophageal squamous cell carcinoma in our hospital from January 2013 to January 2016 were selected as experiment group and 40 healthy subjects were selected as control group. Patients in experiment group were treated with 6MV X-ray radiation therapy. Serum SCC, CEA, CRFRA21-1, TAG72, CA199 and the cell percentage of peripheral blood CD4+, CD8+ were compared in control group and the experimental group before and after 1 month radiotherapy.Results:Before treatment, the levels of serum SCC, CEA and CRFRA21-1 in the experimental group were significantly higher than those in the control group (P0.05). Before treatment, the cell percentage of peripheral blood CD4+, CD8+ and the ratio of CD4+/CD8+ in experimental group was significantly lower than that of the control group, the percentage of peripheral blood CD8+ in the experimental group was significantly higher than that in the control group (P0.05), and in the experimental group, the proportion of CD4+ cells and the tatio of CD4+/CD8+in peripheral blood was significantly lower than that of the control group, the proportion of CD8+ was significantly higher than that of the control group (P<0.05).Conclusions: Radiotherapy can significantly reduce the serum SCC, CEA, CRFRA21-1, TAG72 and CA199 levels of the patients with esophageal squamous cell carcinoma, but have less influence on the T lymphocyte subsets.

  13. Serum tetranectin is an independent prognostic marker in colorectal cancer and weakly correlated with plasma suPAR, plasma PAI-1 and serum CEA

    DEFF Research Database (Denmark)

    Høgdall, Claus K; Christensen, Ib J; Stephens, Ross W

    2002-01-01

    Soluble tetranectin (TN) was measured preoperatively in serum from 567 patients with primary colorectal cancer and levels were tested for association with prognosis. The prognostic significance of TN was also compared to that of plasminogen-activator inhibitor-1 (PAI-1), urokinase plasminogen...... activator (uPAR) and carcinoembryonic antigen (CEA). Significantly shorter survival was found for patients with TN levels below a cut-off point of 7.5 mg/l compared to patients with levels above, as illustrated by Kaplan-Meier curves. By Cox analyses, log TN, log soluble uPAR as well as log CEA were found...... to have an independent prognostic value for survival (log TN: HR = 0.47, 95% CI: 0.29-0.76); log soluble uPAR: HR = 1.65, 95% CI: 1.18-2.31; log CEA: HR = 1.I1, 95% CI: 1.03-1.20). Based on the multivariate model, a patient with a combination of low levels of TN and PAI-1 and elevated levels of soluble u...

  14. Civilisation/Cultural Studies in Grenoble.

    Science.gov (United States)

    Revauger, Jean-Paul

    1993-01-01

    The professional core of civilization/cultural studies (CCS) lies in the study of the relationship between context and discourse. Here, the necessity for the perspective of the outsider, combined with linguistic competence, creates the possibility of a distinctive disciplinary basis for CCS. (Author)

  15. Neuropeptide Y (NPY) in the central nucleus of the amygdala (CeA) does not affect ethanol-reinforced responding in binge-drinking, nondependent rats.

    Science.gov (United States)

    Henderson, Angela N; Czachowski, Cristine L

    2012-03-01

    The central nucleus of the amygdala (CeA) has been implicated as having a significant role in mediating alcohol-drinking behavior. Neuropeptide Y (NPY) has been investigated as a potential pharmacotherapeutic due to its ability to attenuate ethanol intake, particularly when administered into the CeA. Previous research suggests, though the evidence is somewhat conflicting, that the efficacy of NPY is contingent upon genetic background and/or prior history of ethanol dependence in rats. However, studies looking at the effects of NPY in nonselected animals lacking a history of ethanol dependence have two factors that could impact the interpretation of the results: ethanol history/selection AND relatively low baseline ethanol intakes as compared to ethanol-dependent and/or genetically selected controls. The purpose of the present study was to generate higher baseline ethanol intakes upon which to examine the effects of NPY on ethanol and sucrose drinking in nonselected rats using a binge drinking model. Long Evans rats were trained to complete a single response requirement resulting in access to either 2% sucrose (Sucrose Group) or 2% sucrose/10% ethanol (Ethanol Group) for a 20-min drinking session. On treatment days, rats were bilaterally microinjected into the CeA with aCSF or one of three doses of NPY (0.25μg, 0.50μg, or 1.00μg/.5μL). Subjects in the Ethanol Group were consuming an average of 1.2g/kg of ethanol (yielding BELs of ~90mg%) during the 20min access period following aCSF treatments. The results revealed that NPY had no effect on either sucrose or ethanol consumption or on appetitive responding (latency to respond). Overall, the findings indicate that even a history of binge-like ethanol consumption is not sufficient to recruit CeA NPY activity, and are consistent with previous studies showing that the role of NPY in regulating ethanol reinforcement in the CeA may be contingent upon a prior history of ethanol dependence.

  16. CRYOPAD on the triple-axis spectrometer TAS-1 at JAERI

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, Masayasu [Advanced Science Research Center, Japan Atomic Energy Research Institute, 2-4 Shirakata Shirane, Tokai, Naka, Ibaraki 319-1195 (Japan)]. E-mail: takeda@neutrons.tokai.jaeri.go.jp; Nakamura, Mitsutaka [Advanced Science Research Center, Japan Atomic Energy Research Institute, 2-4 Shirakata Shirane, Tokai, Naka, Ibaraki 319-1195 (Japan); Kakurai, Kazuhisa [Advanced Science Research Center, Japan Atomic Energy Research Institute, 2-4 Shirakata Shirane, Tokai, Naka, Ibaraki 319-1195 (Japan); Lelievre-berna, Eddy [Institut Laue-Langevin, 6 rue Jules Horowitz BP 156 - 38042 Grenoble Cedex 9 (France); Tasset, Francis [Institut Laue-Langevin, 6 rue Jules Horowitz BP 156 - 38042 Grenoble Cedex 9 (France); Regnault, Louis-Pierre [CEA-Grenoble, Department de Recherche Fondamentale sur la Matiere Condensee, SPSMS-MDN, F-38054 Grenoble Cedex 9 (France)

    2005-02-15

    CRYOgenic Polarization Analysis Device (CRYOPAD) has been introduced to the triple-axis spectrometer TAS-1 at JRR-3 in JAERI. ILL, CEA-Grenoble and JAERI assembled three third-generation CRYOPADs in the framework of EC/ENPI (ILL and CEA-Grenoble), and in the framework of the MoU between ILL and JAERI. One is installed on the ILL instrument D3 (Millennium Project) and the other on the CEA-Grenoble instrument IN22. The JAERI CRYOPAD is now in commissioning. The current status of the CRYOPAD on TAS-1 is reported.

  17. Joint tests at INL and CEA of a transient hot wire needle probe for in-pile thermal conductivity measurement

    Energy Technology Data Exchange (ETDEWEB)

    Daw, J.E.; Knudson, D.L. [Idaho National Laboratory, Idaho Falls, ID 83415, (United States); Villard, J.F.; Liothin, J.; Destouches, C. [CEA, DEN, DER, Instrumentation Sensors and Dosimetry Laboratory, Cadarache, F-13108 St Paul-Lez-Durance, (France); Rempe, J.L. [Rempe and Associates, LLC, Idaho Falls, ID, 83404 (United States); Matheron, P. [CEA, DEN, DEC, Uranium Fuels Laboratory, Cadarache, F-13108 St Paul-Lez-Durance, (France); Lambert, T. [CEA, DEN, DEC, Innovative Fuel Design and Irradiation Laboratory, Cadarache, F-13108 St Paul-Lez-Durance, (France)

    2015-07-01

    fabricated for both room temperature proof-of-concept evaluations and high temperature testing. Evaluations have been performed jointly by the INL and the French Alternative Energies and Atomic Energy Commission (CEA), both in Idaho Falls (USA) and in Cadarache (France), in the framework of a collaborative program for instrumentation of Material Testing Reactors. Initial tests were conducted on samples with a large range of thermal conductivities and temperatures ranging from 20 deg. C to 600 deg. C. Particularly, tests were recently performed on a sample having thermal conductivity and dimensions similar to UO{sub 2} and MOX nuclear fuels, in order to validate the ability of this sensor to operate for in-pile characterization of Light Water Reactors fuels. The results of the tests already completed at INL and CEA indicate that the Transient Hot Wire Needle Probe offers an enhanced method for in-pile detection of thermal conductivity. (authors)

  18. Rooting of herbaceous minicuttings of passion fruit/ Enraizamento de miniestacas herbáceas de maracujazeiro amarelo

    Directory of Open Access Journals (Sweden)

    Rudival Faquim

    2007-08-01

    Full Text Available The objective of this work was to evaluate the effect of the basal cut, leaf presence and the treament with a root suspension in the rooting of herbaceous minicuttings of yellow passion fruit. The experiment was realized in a greenhouse using minicuttings with 8 cm of lenght and two nodes, collected from yellow passion fruit seedlings. The longitudinal basal cut in the minicuttings was done until the basal node. The leaves were removed or a half of a single leaf was maintained in the apical node. The minicuttings were treated with a root suspension in water in three concentrations (0, 100 e 200 g L-1. After 58 days, the rooting percentage, the number of roots and the root dry matter produced per minicutting were determined. The entirely randomized experimental design was used in a factorial esqueme (2 x 2 x 3 with three replications. The propagation of the yellow passion fruit by herbaceous minicuttings was viable and the presence of the half of a single leaf in the apical node give a higher production of number and dry matter of roots. The basal cut was only a little favourable to the production of roots and the treatment with a root suspension did not present a benefit to the plant propagation.Este trabalho objetivou avaliar a influência do corte basal, da presença da folha e do tratamento com suspensão de raízes no enraizamento de miniestacas herbáceas de maracujazeiro amarelo. O experimento foi conduzido em casa de vegetação com miniestacas de 8 cm de comprimento e dois nós, obtidas de mudas de maracujazeiro. O corte longitudinal na base das estacas foi feito até o nó basal. Foram retiradas as folhas ou mantida a metade da folha do nó apical. As miniestacas foram tratadas com suspensão de raízes mais água nas concentrações de 0, 100 e 200 g L-1. Após 58 dias, determinou-se a porcentagem de estacas enraizadas, o número de raízes emitidas e a massa seca de raízes por estaca. O delineamento experimental utilizado foi o

  19. Artrite da gota tofácea crônica mimetizando artrite reumatoide Chronic tophaceous gout mimicking rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Juliana F. Sarmento

    2009-12-01

    Full Text Available A gota é um distúrbio no metabolismo das purinas, usualmente associado à ocorrência de crises recorrentes de artrite nas articulações dos membros inferiores em homens entre 40-50 anos, e com o desenvolvimento de tofos subcutâneos nos pacientes com doença de longa evolução. Casos de pacientes com artrite gotosa crônica que mimetizam quadros de artrite reumatoide e vice-versa são raros. Descrevemos o caso de um paciente de 56 anos, com quadro de artrite poliarticular, simétrica e deformante, comprometendo principalmente as articulações de mãos e punhos, com nódulos subcutâneos difusos pelo corpo, alterações radiográficas atípicas e urolitíase, que, após avaliação clínica e dos exames complementares, recebeu diagnóstico de gota tofácea crônica mutilante mimetizando artrite reumatoide.Gout is a disorder of purine metabolism, usually associated with recurrent bouts of arthritis in the joints of the lower limbs, affecting men 40 to 50 years of age, which leads to the development of subcutaneous tophi in patients with long-lasting disease. Cases of patients with chronic gouty arthritis mimicking rheumatoid arthritis, and vice-versa, are rare. This report describes the case of a 56-year old male with symmetric, deforming, and polyarticular arthritis affecting, specially, the joints of the hands and wrists, with diffuse subcutaneous nodules throughout his body, atypical radiographic findings, and urolithiasis. Following clinical evaluation and additional tests, this patient received a diagnosis of chronic tophaceous gout mimicking mutilating rheumatoid arthritis.

  20. New trends in γ-ray imaging with CdZnTe/CdTe at CEA-Leti

    Science.gov (United States)

    Verger, Loïck; Gros d'Aillon, Eric; Monnet, Olivier; Montémont, Guillaume; Pelliciari, Bernard

    2007-02-01

    Increasing interest in CdTe/CZT for γ-ray imaging has marked the last 10 years with progress in crystal growth, device technology, integrated electronics and signal processing. The purpose of this paper is to present recent advances in these four fields at CEA-LETI. A new method to grow very large dimension CZT up to 300 mm in diameter is presented. MS-contact process control allows design of very small electrodes (100 μm pitch) and results on long-term stability are presented. The development of low-noise front-end integrated electronics and new interconnects technologies have made "pixel detectors" feasible. Significant effort has been focused on reaching high-energy resolution as well as high detection efficiency. The combination of signal processing such as bi-parametric (BP) approaches and electrode design presents an interest in charge loss compensation for a large range of μτ products, tailing reduction due to geometric effect and depth of interaction information. New digital approaches may give drastic advantages to push the limit of spectrometric performance. In the field of γ-ray application, single-channel device for per-operative probes and small 2-D imager for molecular imaging are the most promising ones. By using a tailored "mixed" electrode (small anode and capacitive grid Frich effect) and a BP correction, an energy resolution of 1% at 662 keV has been demonstrated with CZT based 8×8×15 mm 3 detector. New results of 3-D CZT detectors for μPET imaging are presented with a measured coincidence time of 2.6 ns FWHM and an expected spatial resolution of 1 mm FWHM.

  1. CEA blood test

    Science.gov (United States)

    Carcinoembryonic antigen blood test ... A blood sample is needed . ... When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing or a slight bruise. ...

  2. Near infra-red photoimmunotherapy with anti-CEA-IR700 results in extensive tumor lysis and a significant decrease in tumor burden in orthotopic mouse models of pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Ali A Maawy

    Full Text Available Photoimmunotherapy (PIT of cancer utilizes tumor-specific monoclonal antibodies conjugated to a photosensitizer phthalocyanine dye IR700 which becomes cytotoxic upon irradiation with near infrared light. In this study, we aimed to evaluate the efficacy of PIT on human pancreatic cancer cells in vitro and in vivo in an orthotopic nude mouse model. The binding capacity of anti-CEA antibody to BxPC-3 human pancreatic cancer cells was determined by FACS analysis. An in vitro cytotoxicity assay was used to determine cell death following treatment with PIT. For in vivo determination of PIT efficacy, nude mice were orthotopically implanted with BxPC-3 pancreatic tumors expressing green fluorescent protein (GFP. After tumor engraftment, the mice were divided into two groups: (1 treatment with anti-CEA-IR700 + 690 nm laser and (2 treatment with 690 nm laser only. Anti-CEA-IR700 (100 μg was administered to group (1 via tail vein injection 24 hours prior to therapy. Tumors were then surgically exposed and treated with phototherapy at an intensity of 150 mW/cm2 for 30 minutes. Whole body imaging was done subsequently for 5 weeks using an OV-100 small animal imaging system. Anti-CEA-IR700 antibody bound to the BxPC3 cells to a high degree as shown by FACS analysis. Anti-CEA-IR700 caused extensive cancer cell killing after light activation compared to control cells in cytotoxicity assays. In the orthotopic models of pancreatic cancer, the anti-CEA-IR700 group had significantly smaller tumors than the control after 5 weeks (p<0.001. There was no significant difference in the body weights of mice in the anti-CEA-IR700 and control groups indicating that PIT was well tolerated by the mice.

  3. Development of a quantitative Real-Time PCR for micrometastasis detection using CEA in peripheral blood and bone marrow specimens of gastric cancer patients

    Directory of Open Access Journals (Sweden)

    Dardaei Alghalandis L

    2009-11-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Gastric adenocarsinoma is the first leading fatal malignancy in Iran. Despite advances in novel therapeutics approaches for gastric cancer (GC patient, tumor dissemination via blood stream to distant organ is still the major cause of death. Therefore, there is urgent need to establish sensitive methods for early detection of disseminated tumor cells in peripheral blood (PB and bone marrow (BM specimens of gastric cancer patients. "n"nMethods: In the present study, we use Carcinoma Embryonic Antigen (CEA as a tumor marker and Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH as an internal control to detection and quantification of disseminated tumor cells in PB and BM specimens of affected individuals. Total RNA was extracted from AGS (gastric cancer cell line and CEA and GAPDH fragments were generated by reverse transcription. The amplified fragments were cloned into pTZ57R/T vector separately. Double cloning of these genes has done into one pTZ57R/T vector. Serial dilution of this recombinant plasmid is used to construct standard curve, each containing a known amount of input copy number. Total RNA was extracted from BP and BM specimens of 35 GC patients. cDNA of the specimens were synthesized by reverse

  4. Changes of Serum Trace Elements, AFP, CEA, SF, T3, T4 and IGF- Ⅱ in Different Periods of Rat Liver Cancer

    Institute of Scientific and Technical Information of China (English)

    Hong-xu Zhang; Dan-dan Liu; Bai-jie Jin; Ya-wei Wang; Qj Liu; Ru-bing Duan; Peng Zhao; Ming-xia Ma

    2011-01-01

    Objective:Based on liver cancer model built in SD rats,the contents of trace elements (Cu,Fe,Zn,Ca and Mg),AFP,CEA,SF,TH and IGF-Ⅱ in serum were measured at different stages to explore the molecular changes during the rat liver cancer development.Methods:The SD rat liver cancer model was built by using diethylnitrosamine (DENA) as the mutagen.During 16 weeks of DENA gavage,blood samples were taken in the 14th,28th,56th,77th,105th and 112th days respectively after the first day of gavage with DENA,then the contents of five trace elements (Cu,Fe,Zn,Ca and Mg),T3,T4,IGF-Ⅱ,AFP,CEA and SF in serum were determined.Results:During the development of the rat liver cancer,in the test group,the Cu content significantly increased in serum,while the contents of Fe,Zn and Ca significantly decreased.The content of Mg showed no significant change.AFP and CEA of the test group showed same expression level with the control group; while the content of SF was lower than that of the control group when cancerization appeared.T3 and T4 increased at the first stage and then went down,and the content of IGF-Ⅱ was always high.Conclusion:Cu,Fe,Zn,Ca,T3,T4,SF and IGF-Ⅱ are closely related to the development of liver cancer.The changes of their contents in the development of cancer could enlighten the researches on cancer pathogenesis and prevention.

  5. A comparative study of mucin-like carcinoma-associated antigen (MCA), CA 125, CA 19-9 and CEA in patients with ovarian cancer.

    Science.gov (United States)

    Koelbl, H; Schieder, K; Neunteufel, W; Bieglmayer, C

    1989-01-01

    A mucin-like carcinoma associated antigen (MCA), which is recognized by the monoclonal antibody b-12, was found to be elevated in sera of breast cancer patients. Since an immunohistochemical reaction of the monoclonal antibody b-12 was found in epithelial tumors of the ovary we investigated MCA serum levels in 50 patients with ovarian cancer (mean age 59 years, range 31-81 years). In addition, CA 125, CA 19-9 and CEA were determined to compare sensitivity, specificity and the predictive value of the positive test of each parameter used in this study. Blood samples were obtained in 20 patients with progressive disease and in 30 patients during disease free intervals. The MCA serum levels of patients with progressive ovarian cancer (mean +/- SD: 14.7 +/- 14.6 U/ml) did not differ significantly from those of patients in remission (mean +/- SD: 8.2 +/- 5.3 U/ml) or from values of a healthy control group (mean +/- SD: 7.7 +/- 3.8 U/ml, n = 70). Women with progressive disease displayed significantly higher CA 125 (p less than 0.0001) and CEA (p less than 0.0063) serum levels than patients in remission. No significant difference was found for CA 19-9 in patients with ovarian cancer, irrespective of the clinical status. Considering marker surge and tumor progression, the highest sensitivity was found for CA 125 (75%). Sensitivities of the other markers were significantly lower and reached only 25-35%. The predictive value of elevated marker levels as well as specificity of the marker substances were similar. Sensitivity could be extended to 90% if elevation of CA 125, CA 19-9, CEA and MCA were taken into consideration, however specificity was lowered by using this marker combination.

  6. Evaluation of the concrete shield compositions from the 2010 criticality accident alarm system benchmark experiments at the CEA Valduc SILENE facility

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Thomas Martin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Celik, Cihangir [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dunn, Michael E [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wagner, John C [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McMahan, Kimberly L [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Authier, Nicolas [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Jacquet, Xavier [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Rousseau, Guillaume [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Wolff, Herve [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Savanier, Laurence [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Baclet, Nathalie [French Atomic Energy Commission (CEA), Centre de Valduc, Is-sur-Tille (France); Lee, Yi-kang [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Trama, Jean-Christophe [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Masse, Veronique [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Gagnier, Emmanuel [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Naury, Sylvie [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Blanc-Tranchant, Patrick [French Atomic Energy Commission (CEA), Centre de Saclay, Gif sur Yvette (France); Hunter, Richard [Babcock International Group (United Kingdom); Kim, Soon [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dulik, George Michael [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, Kevin H. [Y-12 National Security Complex, Oak Ridge, TN (United States)

    2015-01-01

    In October 2010, a series of benchmark experiments were conducted at the French Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA) Valduc SILENE facility. These experiments were a joint effort between the United States Department of Energy Nuclear Criticality Safety Program and the CEA. The purpose of these experiments was to create three benchmarks for the verification and validation of radiation transport codes and evaluated nuclear data used in the analysis of criticality accident alarm systems. This series of experiments consisted of three single-pulsed experiments with the SILENE reactor. For the first experiment, the reactor was bare (unshielded), whereas in the second and third experiments, it was shielded by lead and polyethylene, respectively. The polyethylene shield of the third experiment had a cadmium liner on its internal and external surfaces, which vertically was located near the fuel region of SILENE. During each experiment, several neutron activation foils and thermoluminescent dosimeters (TLDs) were placed around the reactor. Nearly half of the foils and TLDs had additional high-density magnetite concrete, high-density barite concrete, standard concrete, and/or BoroBond shields. CEA Saclay provided all the concrete, and the US Y-12 National Security Complex provided the BoroBond. Measurement data from the experiments were published at the 2011 International Conference on Nuclear Criticality (ICNC 2011) and the 2013 Nuclear Criticality Safety Division (NCSD 2013) topical meeting. Preliminary computational results for the first experiment were presented in the ICNC 2011 paper, which showed poor agreement between the computational results and the measured values of the foils shielded by concrete. Recently the hydrogen content, boron content, and density of these concrete shields were further investigated within the constraints of the previously available data. New computational results for the first experiment are now available

  7. 血清 TSA 和 CEA 联合检测对2型糖尿病合并结直肠癌的诊断价值%Diagnostic value of combined detection of serum TSA and CEA in type 2 diabetes mellitus complicating colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    刘瑞东; 王小丽

    2016-01-01

    目的:探讨血清总唾液酸(TSA)和癌胚抗原(CEA)联合检测对2糖尿病合并结直肠癌患者的诊断价值。方法选取结直肠癌合并2型糖尿病患者60例(A组),单纯结直肠癌患者55例(B组),同期的健康者60例(C组),采用化学发光法检测各组血清TSA和CEA水平;对手术切除治疗的患者进行随访半年,检测血清TSA和CEA水平。结果与B组(34.55%)和C组(1.67%)相比较,A组 TSA和CEA联合检测敏感率最高(78.33%),差异具有统计学意义(P<0.05);且A组患者血清TSA[(791.26±135.90)mg/L]及CEA[(48.45±2.67)ng/mL]水平高于B组和C组,差异有统计学意义(P<0.01);A组和B组血清 TSA和CEA水平均较手术前降低,差异有统计学意义(P<0.05)。结论联合检测血清TSA和CEA水平,能为2型糖尿病合并结直肠癌的诊断、预后、复发提供更早、更灵敏的检测指标。%Objective To investigate the diagnostic value of combined detection of serum total sialic acid (TSA) and carcino‐embryonic antigen (CEA) in type 2 diabetes mellitus (T2DM ) complicating colorectal cancer . Methods Sixty of T2DM complicating colorectal cancer were selected as the group A ,other 55 cases of pure colorec‐tal cancer were selected as the group B and contemporaneous 60 healthy persons as the group C .The levels of serum TSA and CEA in each group were detected by chemiluminescence method;at the same time ,the factors of ages ,body mass index (BMI) and series of tumor biochemical detection were compared among various groups;the cases of sur‐gical resection were followed up for 6 months ,and serum TSA and CEA levels were detected .Results Compared with group B (34 .55% ) and C (1 .67% ) ,the sensitivity of combined detection of TSA and CEA was highest (78 .33% ) ,and the difference had statistical significance (P<0 .05);moreover the levels of serum CEA and TSA in the group A

  8. Association of Neisseria gonorrhoeae Opa(CEA with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response.

    Directory of Open Access Journals (Sweden)

    Qigui Yu

    Full Text Available Infection with Neisseria gonorrhoeae (N. gonorrhoeae can trigger an intense local inflammatory response at the site of infection, yet there is little specific immune response or development of immune memory. Gonococcal surface epitopes are known to undergo antigenic variation; however, this is unlikely to explain the weak immune response to infection since individuals can be re-infected by the same serotype. Previous studies have demonstrated that the colony opacity-associated (Opa proteins on the N. gonorrhoeae surface can bind human carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1 on CD4⁺ T cells to suppress T cell activation and proliferation. Interesting in this regard, N. gonorrhoeae infection is associated with impaired HIV-1 (human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte (CTL responses and with transient increases in plasma viremia in HIV-1-infected patients, suggesting that N. gonorrhoeae may also subvert immune responses to co-pathogens. Since dendritic cells (DCs are professional antigen presenting cells (APCs that play a key role in the induction of an adaptive immune response, we investigated the effects of N. gonorrhoeae Opa proteins on human DC activation and function. While morphological changes reminiscent of DC maturation were evident upon N. gonorrhoeae infection, we observed a marked downregulation of DC maturation marker CD83 when the gonococci expressing CEACAM1-specific Opa(CEA, but not other Opa variants. Consistent with a gonococcal-induced defect in maturation, Opa(CEA binding to CEACAM1 reduced the DCs' capacity to stimulate an allogeneic T cell proliferative response. Moreover, Opa(CEA-expressing N. gonorrhoeae showed the potential to impair DC-dependent development of specific adaptive immunity, since infection with Opa(CEA-positive gonococci suppressed the ability of DCs to stimulate HIV-1-specific memory CTL responses. These results reveal a novel mechanism to explain

  9. The prognostic value of preoperative serum levels of CEA, CAl9-9 and CA72-4 in patients with colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    Chao Xu Zheng; Wen Hua Zhan; Ji Zong Zhao; Dong Zheng; Dong Ping Wang; Yu Long He; Zhang Qing Zheng

    2001-01-01

    @@INTRODUCTION Carcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6].

  10. Half-Antibody Functionalized Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery to Carcinoembryonic Antigen (CEA) Presenting Pancreatic Cancer Cells

    Science.gov (United States)

    Hu, Che-Ming Jack; Kaushal, Sharmeela; Tran Cao, Hop S.; Aryal, Santosh; Sartor, Marta; Esener, Sadik; Bouvet, Michael; Zhang, Liangfang

    2010-01-01

    Current chemotherapy regimens against pancreatic cancer are met with little success as poor tumor vascularization significantly limits the delivery of oncological drugs. High-dose targeted drug delivery, through which a drug delivery vehicle releases a large payload upon tumor localization, is thus a promising alternative strategy against this lethal disease. Herein, we synthesize anti-CEA half-antibody conjugated lipid-polymer hybrid nanoparticles and characterize their ligand conjugation yields, physicochemical properties, and targeting ability against pancreatic cancer cells. Under the same drug loading, the half-antibody targeted nanoparticles show enhanced cancer killing effect compared to the corresponding non-targeted nanoparticles. PMID:20394436

  11. Evaluación de la actividad repelente de aceites esenciales de plantas Piperáceas del departamento de Chocó, Colombia

    OpenAIRE

    2015-01-01

    El objetivo de este trabajo fu e determinar la composición química volátil del aceite esencial de varias especies de Piper áceas ( Piper dilatatum, Piper aduncum, Piper divaricatum, Piper sp, Piper sanctifelicis) y la actividad repelente de ellos contra el gorgojo de granos almacenados Tribolium castaneum Herbst. Los aceites esenciales se obtuvieron por hidrodestilación, la separación e identificación de los component es volátiles se realizó por cromatografía de gase...

  12. The effect of high level natural ionizing radiation on expression of PSA, CA19-9 and CEA tumor markers in blood serum of inhabitants of Ramsar, Iran.

    Science.gov (United States)

    Heidari, Mohammad Hassan; Porghasem, Mohsen; Mirzaei, Nazanin; Mohseni, Jafar Hesam; Heidari, Matine; Azargashb, Eznollah; Movafagh, Abolfazl; Heidari, Reihane; Molouki, Aidin; Larijani, Leila

    2014-02-01

    Since several high level natural radiation areas (HLNRAs) exist on our planet, considerable attention has been drawn to health issues that may develop as the result of visiting or living in such places. City of Ramsar in Iran is an HNLRA, and is a tourist attraction mainly due to its hot spas. However, the growing awareness over its natural radiation sources has prompted widespread scientific investigation at national level. In this study, using an ELISA method, the level of expression of three tumor markers known as carcinoembryonic antigen (CEA), prostate-specific antigen (PSA) and carcino antigen 19-9 (CA19-9) in blood serum of 40 local men of Ramsar (subject group) was investigated and compared to 40 men from the city of Noshahr (control group). Noshahr was previously identified as a normal level natural radiation area (NLNRA) that is some 85 km far from Ramsar. According to statistical analysis, there was a significant difference in the levels of PSA and CA19-9 markers between the two groups (p < 0.001) with those of Ramsar being considerably higher. CEA level did not show any difference. Although some of the volunteers tested positive to the markers, they were in good health as confirmed by the physician. Moreover, the high number of positive markers in Noshahr was considerable. Therefore, future study is needed to further validate this result and to determine the level of positivity to tumor markers in both cities.

  13. Seletividade de inseticidas, recomendados para cucurbitáceas para Trichogramma atopovirilia Oatman & Platner (Hymenoptera: Trichogrammatidae em condições de laboratório

    Directory of Open Access Journals (Sweden)

    Dirceu Pratissoli

    2011-10-01

    Full Text Available As brocas-das-cucurbitáceas Diaphania spp. são as principais pragas das cucurbitáceas, podendo ocasionar perdas de até 100% na produção. A fim de reduzir o uso de inseticidas, o controle biológico, aplicado com parasitoides do gênero Trichogramma, tem-se destacado. Objetivou-se avaliar a seletividade dos ingredientes ativos abamectina, tiacloprido e clorfenapir, para Trichogramma atopovirilia Oatman & Platner (Hymenoptera: Trichogrammatidae. Para isso, 20 fêmeas recém-emergidas de T. atopovirilla foram individualizadas, em tubos de vidro (2,5 cm de diâmetro x 8,5 cm de comprimento, e oferecidas cartelas com 30 ovos de Diaphania hyalinata (Linnaeus (Lepidoptera: Pyralidae, previamente imersas por cinco segundos em calda química. Os ingredientes ativos abamectina, tiacloprido e clorfenapir não afetaram o parasitismo de T. atopovirilia. Clorfenapir reduziu a emergência. Abamectina e tiacloprido são os mais recomendados no manejo integrado de pragas, pois foram os que se mostraram mais seletivos a T. atopovirilia em ovos de D. hyalinata.

  14. Enterobacteriáceas en partes externas del estadío adulto de Periplaneta americana “cucaracha” capturadas en el mercado Modelo, Iquitos, Perú

    Directory of Open Access Journals (Sweden)

    Xandrix Augusto Ruiz Cabezas

    2015-06-01

    Full Text Available Este estudio, determinó la presencia de Enterobacteriáceas en partes externas del estadío adulto de Periplaneta americana “cucaracha” capturadas en el mercado Modelo de la ciudad de Iquitos. Fueron colectados un total de 68 “cucarachas”, y luego cada una fue depositada en un frasco estéril y trasladadas vivas para el análisis respectivo al laboratorio de Investigación de la Facultad de Ciencias Biológicas; después del aislamiento, las colonias observadas fueron sometidas a pruebas de identificación bioquímica tales como: Prueba de oxidasa, utilización de glucosa, lactosa y sacarosa (agar TSI, pruebas VP-RM, indol, hidrólisis de la úrea. La prevalencia de Enterobacteriáceas se determinó utilizando el método estadístico de distribución de frecuencias y la prueba no paramétrica de Chi cuadrado para prueba de hipótesis. De las 68 cucarachas analizadas se aislaron 118 colonias caracterizadas como lactosa positiva y lactosa negativa, representando el 71 % y 29 % respectivamente de las muestras analizadas.  Finalmente, se aisló e identificó 5 cepas bacterianas, categorizadas en 5 géneros: Providencia (25%, Edwardsiella (9%, Citrobacter (14%, Enterobacter (31% y Klebsiella (21%.

  15. Impact properties of electron beam welds of V–4Ti–4Cr alloys NIFS-HEAT-2 and CEA-J57

    Energy Technology Data Exchange (ETDEWEB)

    Tsisar, Valentyn, E-mail: valentyn_tsisar@ipm.lviv.ua [National Institute for Fusion Science (NIFS), 322-6 Oroshi, Toki, Gifu 509-5292 (Japan); Physical–Mechanical Institute of National Academy of Sciences of Ukraine (PhMI NASU), 5 Naukova Street, 79601 Lviv (Ukraine); Karlsruhe Institute of Technology (KIT), Institute for Applied Materials – Material Process Technology (IAM-WPT), Hermann-von-Helmholtz-Platz, 1, 76344 Eggenstein-Leopoldshafen (Germany); Nagasaka, Takuya [National Institute for Fusion Science (NIFS), 322-6 Oroshi, Toki, Gifu 509-5292 (Japan); Le Flem, Marion [CEA, DEN, DMN, SRMA, F-91191 Gif Sur Yvette (France); Yeliseyeva, Olga [Physical–Mechanical Institute of National Academy of Sciences of Ukraine (PhMI NASU), 5 Naukova Street, 79601 Lviv (Ukraine); Konys, Jürgen [Karlsruhe Institute of Technology (KIT), Institute for Applied Materials – Material Process Technology (IAM-WPT), Hermann-von-Helmholtz-Platz, 1, 76344 Eggenstein-Leopoldshafen (Germany); Muroga, Takeo [National Institute for Fusion Science (NIFS), 322-6 Oroshi, Toki, Gifu 509-5292 (Japan)

    2014-10-15

    Highlights: • Electron beam welding was applied for V–4Ti–4Cr alloys NIFS-HEAT-2 and CEA-J57. • Weld metal showed superior impact properties in comparison with base metal. • Expected shift in DBTT to higher temperatures does not take place. - Abstract: The Charpy impact properties and microstructure of bead-on-plate electron beam welds of V–4Ti–4Cr alloys NIFS-HEAT-2 (NH-2) and CEA-J57 (J57) were investigated. Weld metal of both grades demonstrated increase in hardness (HV{sub 100} ∼ 180) in comparison with base metal (HV{sub 100} ∼ 135) due to decomposition of Ti–C,O,N precipitates followed by the solid-solution hardening of V-matrix with oxygen. Hardness decreases gradually from the weld metal through the heat affected zone toward the base metal indicating partial decomposition of precipitation bands from the side of heat affected zone directly adjoining weld metal. The latter consists of columnar crystallites (grains) possessing with inner dendritic structure and elongated from the center of weld belt in the direction of heat removal. Thickness of weld metal does not exceed 1 mm while heat affected zone is about 3 mm thick. Absorbed energies of weld metal are superior in comparison with base metal for both grades (NH-2 and J57) while the fracture mode is mainly ductile in the temperature range of impact test from 17 to −196 °C.

  16. 腰硬联合麻醉(CSEA)和硬脊膜外麻醉(CEA)在剖宫产术中的比较探讨

    Institute of Scientific and Technical Information of China (English)

    姚建平

    2009-01-01

    目的:探讨腰硬联合麻醉(CSEA)和硬脊膜外麻醉(CEA)在剖宫产术中的效果.方法:对我院138例急诊剖宫产术患者分别行CSEA和CEA,比较两组麻醉效果及副作用.结果:两组相比各阻滞平面出现时间均有显著差异(P<0.05).最高阻滞平面CSEA组为T(5±1),CEA组为T(7±2),两组有显著性差异.两组低血压发生率CSEA高于CEAse组,有显著性差异.结论:腰硬联合麻醉用于急诊剖宫产术起效快,镇痛效果确实,可以在剖宫产术安全使用此种麻醉方法.

  17. Las ericáceas de la vertiente pacífica de Nariño, Colombia

    Directory of Open Access Journals (Sweden)

    Betancur Julio

    2005-07-01

    (Cavendishia oligantha, Diogenesia alstoniana y Vaccinium sp. nov. y las seis restantes son compartidas con la región  limítrofe del norte del Ecuador. Tres especies (Cavendishia callista, Disterigma pseudokillipiella y Macleania smithiana fueron exclusivas de la llanura del Pacífico (por debajo de 500 m de altitud, 31 especies de la región Andina (por encima de 500 m de altitud y 19 se compartieron entre ambas regiones.
    La mayor riqueza de especies y endemismos se presentó entre 1.000 y 1.600 m de altitud, con 45 especies. Los resultados obtenidos muestran que la vertiente pacífica del departamento de Nariño, Colombia, es la región de América con mayor número de especies de ericáceas por unidad de área.

  18. ACCELERATED AGING OF OLERACEOUS SPECIES SEEDS ENVELHECIMENTO ACELERADO DE SEMENTES DE ESPÉCIES OLERÁCEAS

    Directory of Open Access Journals (Sweden)

    Denis Santiago da Costa

    2011-07-01

    the seedling formation process.

    A qualidade da semente utilizada no processo de produção agrícola é um dos principais fatores considerados para a implantação da cultura. Este trabalho objetivou estudar o efeito do nível de vigor no desempenho de sementes de seis espécies oleráceas. Sementes comerciais de alface, berinjela, brócolis, couve-flor, rúcula e tomate foram submetidas ao envelhecimento acelerado, por 48 e 72 horas, para obtenção de lotes com três níveis de vigor. Obteve-se um lote normal e dois envelhecidos por diferentes períodos. Após a obtenção dos lotes, as sementes foram submetidas a testes de germinação, condutividade elétrica, emergência de plântulas em bandeja, comprimento e massa seca de plântulas. O efeito do envelhecimento acelerado torna-se mais acentuado com o aumento do tempo de exposição das sementes às condições de alta umidade relativa do ar e elevada temperatura. Esta exposição reduz, mais acentuadamente, a qualidade das sementes para algumas espécies, como alface, couve-flor e rúcula, que para outras, como brócolis, tomate e berinjela. Sementes de menor vigor, além de menor germinação e menor emergência, apresentam lentidão no processo de formação de mudas.

  19. Chemistry of complexing molecules and environment. Report of the working group of the Cea ''mission environment''; Chimie des complexants en environnements. Rapport du groupe de travail de la mission environnement

    Energy Technology Data Exchange (ETDEWEB)

    Petit, J.C

    1998-07-01

    The Working group 'Chemistry of Complexing Molecules and Environment' of the Mission Environment (AG/ENV) identified themes for an original positioning of CEA on important issues of environmental research if a sufficiently strong demand appears. The research of CEA on the environment should be complementary to actions undertaken by other partners (official institutions, research organizations and industrial firms). The themes suggested are: the synthesis of new chelating molecules and new materials having specific properties, with the support of theoretical chemistry and modeling, analytical physical chemistry and speciation of species in relation to their eco-toxicity and their biogeochemical mobility in the natural environment. These themes, illustrated by examples of actions in progress at CEA or likely to be launched quickly, draw largely from recognized competences of the teams, generally developed for finalized nuclear applications: experimental, theoretical and instrumental competences. (author)

  20. The serum levels of tumor marker CA19-9, CEA, CA72-4, and NSE in type 2 diabetes without malignancy and the relations to the metabolic control

    Science.gov (United States)

    Shang, Xiaojing; Song, Chunqing; Du, Xiaoming; Shao, Hailin; Xu, Donghong; Wang, Xiaolai

    2017-01-01

    Objectives: To investigate whether there is a difference in carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), carbohydrate antigen 72-4 (CA72-4), and neuron-specific enolase (NSE) between diabetic and non-diabetic patients. Methods: A retrospective analysis was performed in 268 type 2 diabetic patients and 95 non-diabetic ones, and their serum levels of CA19-9, CEA, CA72-4, and NSE were compared in our endocrine ward at the Tianjin Fourth Central Hospital, Tianjin, China during the period from January to June 2015. The diabetic patients were divided into 4 groups based on glycosylated hemoglobin (HbA1c) levels to investigate the relationship between levels of tumor markers and glucose status. Results: Diabetic patients had higher levels of tumor markers than non-diabetic subjects (CA19-9: 13.0 versus 7.25U/mL, p=0.000; CEA: 2.55 versus 2.25 ng/mL, p=0.012; CA72-4: 1.95 versus 1.50U/mL, p=0.001; NSE: 11.64 versus 10.22ng/mL, p=0.000). CA19-9 levels increased in a stepwise manner with poor diabetes status. CEA levels were increased in patients with HbA1c ≥9% and CA72-4 elevation was predominant in patients with poor glycemic control (HbA1c ≥11%). NSE levels were not associated with metabolic parameters. Conclusion: Serum levels of CA19-9, CEA, CA72-4, and NSE were elevated in type 2 diabetes; however, only CA19-9, CEA, and CA72-4 levels were associated with hyperglycemia. PMID:28133696

  1. Paleoecologia de diatomáceas como subsídios para o conhecimento da evolução paleogeográfica da região costeira do Rio Grande do Sul, Brasil

    OpenAIRE

    2015-01-01

    A partir da premissa de que os estudos de sistemas fluviais de vales incisos desenvolvidos em sistemas lagunares são essenciais para o entendimento da influência das mudanças do nível do mar, na evolução de costas dominadas por ondas, uma abordagem multidisciplinar envolvendo sísmica de alta resolução e análise de diatomáceas é proposta. As diatomáceas encontradas em testemunhos, obtidos em distintos ambientes da zona costeira do Rio Grande do Sul, e amostras superficiais coletadas no interio...

  2. Efeito da fragmentação na assembléia de herbáceas de uma área de floresta Atlântica do Nordeste do Brasil.

    OpenAIRE

    Patrícia Barbosa Lima

    2012-01-01

    A conversão de grandes áreas florestais em pequenos remanescentes direciona diversas alterações físicas e biológicas que influenciam negativamente a biodiversidade das florestas tropicais, mas pouco se sabe sobre as respostas de plantas herbáceas à perturbação humana. Diante disso, o presente estudo objetivou testar as seguintes hipóteses: (1) uma área fragmentada possui menor riqueza, menor diversidade e maior densidade da assembléia de herbáceas do que um ambiente contínuo; (2) existe maior...

  3. Diagnostic value of combination detection of CEA,CYFR21-1,NSE in bronchoalveolar lavage fluid for early lung cancer%肺泡灌洗液中 CEA 、CYFR21-1、NSE 联合检测对早期肺癌的诊断价值

    Institute of Scientific and Technical Information of China (English)

    陈元菁; 顾晔

    2016-01-01

    目的:探讨肺泡灌洗液(BALF)中癌胚抗原(CEA)、细胞角蛋白19片段(CYFR)21‐1、神经元特异性烯醇化酶(NSE)联合检测对早期肺癌的诊断价值,以及其与临床疗效的相关性。方法69例肺癌患者纳入肺癌组,50例肺部良性疾病患者纳入肺良性疾病组。所有患者行肺泡灌洗术(BAL),采用化学发光免疫法检测 BALF 中 CEA 、CYFR21‐1、NSE 水平,比较2组患者及不同临床疗效肺癌患者肿瘤标志物水平的变化。结果肺癌组 BALF 中 CEA 、CYFR21‐1、NSE 水平明显高于肺良性疾病组,差异有统计学意义(P<0.05)。Ⅱ期肺癌患者各肿瘤标志物水平均高于Ⅰ期患者,差异有统计学意义(P<0.05);随着临床疗效的下降,CEA 、CYFR21‐1、NSE 水平逐渐升高(P <0.05);联合检测的灵敏度和特异度分别为62.3%、82.0%,明显高于 CEA 、CY‐FR21‐1、NSE 任一单项的灵敏度和特异度(P<0.05)。结论早期肺癌患者 BALF 中 CEA 、CYFR21‐1、NSE 水平明显升高,且与肺癌病理分期密切相关,联合检测有助于提高早期肺癌检出率及指导临床疗效评估。%Objective To explore the diagnostic value of combination detection of carcino‐embryonic antigen(CEA ) ,cytokeratin 19 fragment 21‐1(CYFR21‐1) ,neuron‐specific enolase(NSE) in bronchoalveolar lavage fluid (BALF) for early lung cancer and its correlation with clinical effects .Methods 69 cases of lung cancer were included into the lung cancer group and 50 cases of benign pulmonary disease were included into the lung benign disease group .All the patients were given bronchoalveolar lavage(BAL) .The chemiluminescence immunoassay was adopted to detect the levels of CEA ,CYFR21‐1 and NSE in BALF .The changes of tumor markers levels were compared between the two groups and among different clinical curative effects in the patients with lung cancer . Results The

  4. Vulnerabilidad de los sistemas de polinización de cactáceas columnares de México Vulnerability of pollination systems of columnar cacti of Mexico

    Directory of Open Access Journals (Sweden)

    Alfonso Valiente-Banuet

    2002-03-01

    Full Text Available Se presenta un análisis geográfico sobre el grado de vulnerabilidad de los sistemas de polinización de cactáceas columnares de México que muestran un síndrome de polinización quiropterófila. Se partió del supuesto que sistemas especializados de polinización serían más vulnerables a la perturbación humana que los generalistas. Los resultados indican que las especies que se ubican en el límite norte de la distribución de las cactáceas columnares muestran patrones generalistas de polinización que las hace menos vulnerables a las perturbaciones que las que habitan el centro de México que presentan sistemas de interacción especializados. Este patrón contrastante podría estar relacionado con los movimientos migratorios de los murciélagos en el norte de la distribución de las cactáceas que pudo haber restringido la respuesta hacia la especialización, en tanto que poblaciones residentes de murciélagos en el centro de México podrían haber favorecido la especialización localAn analysis of the degree of vulnerability of the pollination systems of Mexican columnar cacti showing a chiropterophyllous pollination syndrome was conducted, assuming that specialized pollination interactions would be more vulnerable to human perturbations. The results indicate that the species inhabiting the northern distribution limit of the columnar cacti show generalized pollination systems whereas species inhabiting central Mexico showing specialized pollination interactions would be more vulnerable to perturbations. This contrasting geographic pattern might be related to the migratory movements of the nectar-feeding bats in the northern limit of distribution of the columnar cacti that restricted local specialization, whereas resident nectar-feeding bat populations in south-central Mexico probably favored local specialization

  5. Hallazgo de espeleotemas silíceas en rocas graníticas del batolito de Achala, Sierras Pampeanas de Córdoba

    Directory of Open Access Journals (Sweden)

    Marcela A. Cioccale

    2008-09-01

    Full Text Available Se presentan los primeros resultados en relación con el hallazgo de espeleotemas silíceas en rocas graníticas del batolito de Achala (Córdoba. Estas espeleotemas constituyen formas de acumulación en un ambiente dominado por procesos erosivos; alcanzando un desarrollo de unos de pocos milímetros hasta dos centímetros de espesor. Se localizan en grietas abiertas y paredes de tafonis. Presentan morfologías variadas que incluyen estalactitas y espeleotemas tipo flowstone. Están compuestas por sílice amorfa (ópalo A, yeso y fragmentos detríticos de cuarzo, feldespatos y micas. El modelado geoquímico, mediante el programa PHREEQC, permite simular la formación de estas espeleotemas a partir de procesos de evaporación del agua que circula a través de la roca fracturada.

  6. Results of the 2016 UT modeling benchmark proposed by the French Atomic Energy Commission (CEA) obtained with models implemented in CIVA software

    Science.gov (United States)

    Toullelan, Gwénaël; Chatillon, Sylvain; Raillon, Raphaële; Mahaut, Steve; Lonné, Sébastien; Bannouf, Souad

    2017-02-01

    For several years, the World Federation of NDE Centers, WFNDEC, proposes benchmark studies in which simulated results (in either ultrasonic, X-rays or eddy current NDT configurations) obtained with various models are compared to experiments. This year the proposed UT benchmark proposed by CEA concerns inspection configurations with multi-skips echoes i.e. the incident beam undergoes several skips on the surface and bottom of the specimen before interacting with the defect. This technique is commonly used to inspect thin specimen and/or in case of limited access inspection. This technique relies on the use of T45° mode in order to avoid mode conversion and to facilitate the interpretation of the echoes. The inspections were carried out with two probes of different aperture working at 5MHz.

  7. Systems assessment of water savings impact of controlled environment agriculture (CEA) utilizing wirelessly networked Sense•Decide•Act•Communicate (SDAC) systems.

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Jonathan T.; Baynes, Edward E., Jr.; Aguirre,Carlos (University of Texas at El Paso, El Paso, TX); Jordan, Jon (University of Arizona, Tucson, AZ); Giacomelli, Gene (University of Arizona, Tucson, AZ); Waggoner, Justin (New Mexico State University, Las Cruces, NM); Loest, Clint (New Mexico State University, Las Cruces, NM); Szumel, Leo; Nakaoka, Tyler; Pate, Ronald C.; Berry, Nina M.; Pohl, Phillip Isabio; Aguirre, Francisco Luis (Invernaderos y Maquinaria Aguirre, Cd., Aldama, Chihuahua, Mexico); Aguilar, Jose (University of Texas at El Paso, El Paso, TX); Gupta, Vipin P.; Ochoa, Juan (University of Texas at El Paso, El Paso, TX); Davis, Jesse Zehring; Ramos, Damian (University of Texas at El Paso, El Paso, TX)

    2005-02-01

    Reducing agricultural water use in arid regions while maintaining or improving economic productivity of the agriculture sector is a major challenge. Controlled environment agriculture (CEA, or, greenhouse agriculture) affords advantages in direct resource use (less land and water required) and productivity (i.e., much higher product yield and quality per unit of resources used) relative to conventional open-field practices. These advantages come at the price of higher operating complexity and costs per acre. The challenge is to implement and apply CEA such that the productivity and resource use advantages will sufficiently outweigh the higher operating costs to provide for overall benefit and viability. This project undertook an investigation of CEA for livestock forage production as a water-saving alternative to open-field forage production in arid regions. Forage production is a large consumer of fresh water in many arid regions of the world, including the southwestern U.S. and northern Mexico. With increasing competition among uses (agriculture, municipalities, industry, recreation, ecosystems, etc.) for limited fresh water supplies, agricultural practice alternatives that can potentially maintain or enhance productivity while reducing water use warrant consideration. The project established a pilot forage production greenhouse facility in southern New Mexico based on a relatively modest and passive (no active heating or cooling) system design pioneered in Chihuahua, Mexico. Experimental operations were initiated in August 2004 and carried over into early-FY05 to collect data and make initial assessments of operational and technical system performance, assess forage nutrition content and suitability for livestock, identify areas needing improvement, and make initial assessment of overall feasibility. The effort was supported through the joint leveraging of late-start FY04 LDRD funds and bundled CY2004 project funding from the New Mexico Small Business Technical

  8. Morfometría de semillas en la cactácea amenazada de extinción Astrophytum myriostigma Lemaire

    Directory of Open Access Journals (Sweden)

    Jaime Sánchez-Salas

    2015-07-01

    Full Text Available Se presenta un estudio morfométrico y microestructural en semillas de una población de la cactácea amenazadaAstrophytum myriostigmaLem., removida en su tota- lidad en el sitio por saqueo. Se incluyen resultados que separan tamaños de semillas y embriones (grandes y pequeños así como promedios para ambos. Se realizó una descripción de características en la semilla obtenidas mediante estereoscopía. Se incluye una descripción detallada de la forma y color, así como microestructural del funículo, capa funicular y otras estructuras que le acompañan.

  9. Las Poáceas del Parque Nacional Yanachaga-Chemillén (Oxapampa, Perú. Parte II: Pooideae, Centothecoideae, Arundinoideae, Chloridoideae y Panicoideae

    Directory of Open Access Journals (Sweden)

    María I. La-Torre

    2013-06-01

    Full Text Available Se presenta la segunda parte de un estudio taxonómico de la Familia Poaceae del Parque Nacional Yanachaga-Chemillén y zonas aledañas (Oxapampa, Pasco, Perú. Se presentan 63 especies de Poáceas de las subfamilias Pooideae, Centothecoideae, Arundinoideae, Chloridoideae y Panicoideae, las cuales están incluidas en 37 géneros y 12 tribus. Se incluye una breve descripción de los géneros. Se ha elaborado claves para diferenciar los géneros y especies. Para cada especie se indica su ecología, distribución y el material estudiado.

  10. 化學發光法血清CEA、CA15-3和SF聯合測定對肺癌的診斷價值%Clinical value of combined detection of serum CEA, CA15 3 and SF in lung cancer

    Institute of Scientific and Technical Information of China (English)

    周愛清; 王雪芹; 吴建國

    2001-01-01

    Objective To investigate the clinical value of combined examination of serum CEA, CA15 3 and SF in lung cancer diagnosis. Methods Serum concentrations of CEA, CA153 and SF were measured by chemiluminescent assay (CLA) in 99 patients with lung cancer and 25 patients with benign lung diseases. Results The positive rate of serum CEA, CA15-3 and SF in cases of lung cancer was 50. 5%, 31. 3% and 69. 7%, respectively. Specificity of CEA, CA153 and SF measurements was 76%, 78% and 72%, respectively. In combined measurements, positive results of either two parameters revealed sensitivity and specificity of 82. 8% and 92%, respectively. Conclusion Combined measurements of CEA, CA15 3 and SF had evidently improved sensitivity and specificity in diagnosing lung cancer and thus were of good clinical value.

  11. Key Performance Criteria Affecting the Most the Safety of a Nuclear Waste Long Term Storage : A Case Study Commissioned by CEA

    Energy Technology Data Exchange (ETDEWEB)

    Marvy, A.; Lioure, A; Heriard-Dubreuil, G.; Gadbois, S.; Schneider, T.; Schieber, C.

    2003-02-24

    As part of the work scope set in the French law on high level long lived waste R&D passed in 1991, CEA is conducting a research program to establish the scientific basis and assess the feasibility of long term storage as an option for the safe management of nuclear waste for periods as long as centuries. This goal is a significant departure from the current industrial practice where storage facilities are usually built to last only a few decades. From a technical viewpoint such an extension in time seems feasible provided care and maintenance is exercised. Considering such long periods of time, the risk for Society of loosing oversight and control of such a facility is real, which triggers the question of whether and how long term storage safety can be actually achieved. Therefore CEA commissioned a study (1) in which MUTADIS Consultants (2) and CEPN (3) were both involved. The case study looks into several past and actual human enterprises conducted over significant periods o f time, one of them dating back to the end of the 18th century, and all identified out of the nuclear field. Then-prevailing societal behavior and organizational structures are screened out to show how they were or are still able to cope with similar oversight and control goals. As a result, the study group formulated a set of performance criteria relating to issues like responsibility, securing funds, legal and legislative implications, economic sustainable development, all being areas which are not traditionally considered as far as technical studies are concerned. These criteria can be most useful from the design stage onward, first in an attempt to define the facility construction and operating guiding principles, and thereafter to substantiate the safety case for long term storage and get geared to the public dialogue on that undertaking should it become a reality.

  12. Studies of monoclonal antibodies IOR-CEA-1 and IOR-EGF/R3 labelled with {sup 99m}Tc; Estudo de marcacao dos anticorpos monoclonais IOR-CEA-1 e IOR-EGF/R3 com {sup 99m}Tc

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Carla Roberta de Barros Rodrigues

    2005-07-01

    Nuclear Medicine is a speciality that uses radioisotopes for the diagnosis or treatment of diseases and it is considered one of the best tools among the diagnostic modalities for detection of cancer. {sup 99m}Tc is one of the main isotopes for labelling antibodies and in Nuclear Medicine in general, due to its adequate physical properties, availability and low cost. Labelled monoclonal antibodies have shown promising results for diagnosis and therapy of cancer and their use has brought great experimental and clinical advances in the field of oncology. The main clinical applications of immunoscintigraphy with monoclonal antibodies are staging and evaluation of tumoral reappearance. The antibodies employed in this work were: OIR-CEA-1, a murine monoclonal antibody that acts directly against CEA expressed in several neoplasia in particular those from the gastrointestinal tract (colorectal cancer) and IOR-EGF/R3, a murine monoclonal antibody that binds to the external domain of EGF-R and it has been used in the diagnosis of tumors of epithelial origin. The objectives of this work were the development and optimization of the reduction and purification processes, the radiolabelling techniques and quality control procedures (radiochemical, immunoreactivity and cystein challenge) and imaging studies of monoclonal antibodies OIR-CEA-1 and IOR-EGF/R3, using the simple, fast and efficient method of direct labelling of the antibody with {sup 99m}Tc. The final results was the definition of the best conditions for the preparation of lyophilized reactive kits of OIR-CEA-1 and IOR- EGF/R3 for an efficient diagnostic application in Nuclear Medicine. The most adequate conditions for the labelling of the antibodies were: 1.0 mg Ab, 29 {mu}L MDP, 3.0 {mu}g Sn{sup 2+}, 1 mL of {sup 99m}Tc and 30 min. reaction time. With these conditions the labelling yield was always higher than 95% and the maximum activity of {sup 99m}Tc was about 2220 MBq (60 mCi). The evidences of the efficiency and

  13. 亚临床甲状腺机能亢进患者血清CEA水平的检测及其临床意义%Serum CEA levels in the patients with subclinical hyperthyroidism and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    丘文慧; 廖奇峰

    2015-01-01

    目的:探讨亚临床甲状腺机能亢进(SCHT)患者血清癌胚抗原(CEA)水平的检测及其临床意义. 方法:随机选取2014年3月至2015年3月期间我院收治的SCHT患者128例作为亚甲亢组,另选取30例同期健康查体者作为对照.采用化学发光法检测两组血清CEA水平、血清促甲状腺激素(TSH)和游离甲状腺激素(FT4)水平. 统计两组心率并分析SCHT患者血清CEA水平与其血清TSH水平和心率的关系.结果:亚甲亢组和对照组血清FT4水平比较差异无统计学意义(P>0.05).与对照组比较,亚甲亢组血清TSH水平降低,血清CEA水平和心率则升高;且随着治疗时间的延长,亚甲亢组血清TSH水平逐渐升高,血清CEA水平和心率则逐渐降低,差异有统计学意义(P 0.05) between hyperthyroidism and control groups. Compared to control group,levels of serum TSH were decreased, and levels of CEA and heart rate were increased in SCHT group. With the extension of treatment time, levels of serum TSH were significantly increased (P< 0.05) while levels of serum CEA and heart rate were significantly reduced (P< 0.05) in SCHT group. Pearson correlation analysis results showed that levels of serum CEA were negatively correlated with levels of serum TSH (r = -0.736, P< 0.05), and positively correlated with heart rate (r = 0.843, P< 0.05) in SCHT patients. Conclusions: Levels of serum CEA are related to TSH and heart rate, which may result from heart damage in SCHT patients, leading to increased CEA. Therefore, levels of serum CEA in SCHT patients may be used as reference indicators to evaluate the effectiveness of treatment and heart damage.

  14. Effect of endostar combined with paclitaxel liposome and radiotherapy simultaneously on serum CYFRA21-1, CEA, SCCA, CA125, IL-8 and T lymphocyte subsets in patients with advanced cervical cancer

    Institute of Scientific and Technical Information of China (English)

    Wen-Jing Yang; Lu Wang

    2016-01-01

    Objective:To study the effect of endostar combined with paclitaxel liposome and radiotherapy simultaneously on serum CYFRA21-1, CEA, SCCA, CA125, IL-8 and T lymphocyte subsets in patients with advanced cervical cancer.Methods:A total of 72 patients with advanced cervical cancer in our hospital from January 2014 to February 2016 were enrolled in this study. The subjects were divided into control group (n=36) and experiment group (n=36) randomly. The control group were treated with radiotherapy, the experiment group were treated with endostar combined with paclitaxel liposome and radiotherapy simultaneously. 3 weeks for a period of treatment and the two groups were treated for 4 periods. The serum CYFRA21-1, CEA, SCCA, CA125, IL-8 levels and peripheral blood CD3+, CD4+ and CD8+ cells of the two groups before and after treatment were compared.Results:There were no significantly differences of the serum CYFRA21-1, CEA, SCCA, CA125, IL-8 levels and peripheral blood CD3+, CD4+ and CD8+ cells of the two groups before treatment. The serum CYFRA21-1, CEA, SCCA, CA125 and IL-8 levels of the two groups after treatment were significantly lower than before treatment, and that of experiment were significantly lower than control group. The peripheral blood CD3+, CD4+ cells of the two groups after treatment were significantly lower than before treatment, CD8+ cells of the two groups after treatment were significantly higher than before treatment, and that of experiment group were significantly better than control group.Conclusion: Endostar combined with paclitaxel liposome and radiotherapy simultaneously can significantly reduce the serum CYFRA21-1, CEA, SCCA, CA125 and IL-8 levels, improve peripheral blood CD3+, CD4+ and CD8+ levels of patients with advanced cervical cancer, and it was worthy clinical application.

  15. Effect of paclitaxel liposome combined with nedaplatin on serum HE4, CA125, CA19-9, AFP, CEA and T lymphocyte subsets in patients with advanced ovarian cancer

    Institute of Scientific and Technical Information of China (English)

    Su-Yu Zhu; Jie Tan; Chen-Lu Zhang; Qun-Ying Wu; Xue-Xin Xie; Hua-Fang Yin

    2016-01-01

    Objective:To study the effect of paclitaxel liposome combined with nedaplatin on serum HE4, CA125, CA19-9, AFP, CEA and T lymphocyte subsets in patients with advanced ovarian cancer.Methods:A total of 80 patients with advanced ovarian cancer in our hospital from December 2012 to December 2015 were enrolled in this study. The subjects were divided into control group (n=40) and experiment group (n=40) randomly. The control group were treated with paclitaxel and cisplatin, the experiment group were treated with paclitaxel liposome combined with nedaplatin. 21 days for a period of treatment and the two groups were treated for 3 periods. The serum HE4, CA125, CA19-9, AFP, CEA levels and peripheral blood CD3+, CD4+, CD8+ and NK cells of the two groups before and after treatment were compared. Results:There were no significantly differences of the serum HE4, CA125, CA19-9, AFP, CEA level and peripheral blood CD3+, CD4+, CD8+ and NK cells of the two groups before treatment (P>0.05). The serum HE4, CA125, CA19-9, AFP and CEA level of the two groups after treatment were significantly lower than before treatment (P<0.05), and that of experiment were significantly lower than control group (P<0.05). The peripheral blood CD3+, CD4+, CD8+and NK cells of the two groups after treatment were significantly lower than before treatment (P<0.05), and that of experiment were significantly higher than control group (P<0.05). Conclusions:Paclitaxel liposome combined with nedaplatin can significantly reduce the serum HE4, CA125, CA19-9, AFP and CEA levels, improve peripheral blood CD3+, CD4+, CD8+ and NK levels of patients with advanced ovarian cancer, and it was worthy clinical application.

  16. Clinical relevance of anti-CEA-radioimmunoscintigraphy with the [sup 99m]Tc-monoclonal antibody BW 431/26. Critical evaluation after 119 examinations. Klinische Relevanz der Anti-CEA-Immunszintigraphie mit dem [sup 99m]Tc-markierten monoklonalen Antikoerper BW 431/26. Kritische Bestandsaufnahme nach 119 Untersuchungen

    Energy Technology Data Exchange (ETDEWEB)

    Hach, A.; Piepenburg, R.; Steinert, H.; Lahmann, C.; Hahn, K. (Univ. Mainz, Nuklearmedizinische Klinik (Germany)); Wittig, B.; Dippold, W. (Univ. Mainz, 1. Medizinische Klinik (Germany))

    1992-07-01

    The results of 119 radioimmunoscintigraphies (RIS) in 113 patients with the [sup 99m]Tc-labeled monclonal anti-CEA-antibody BW 431/26 (Behring) have been analysed. The aim of our study was the estimation of the method's sensitivity and specificity under different aspects to find out for which indications and questions the [sup 99m]Tc-RIS is useful. Colorectal primary tumours in 19 patients were scintigraphically detected with a sensitivity of 83% and a specificity of 100%; 3 out of 7 other tumour sites were localised correctly. 55 patients were examined during the follow-up of colorectal cancer. There were 17 out of 22 true positive findings of local recurrences (sensitivity 77%, specificity 88%). Liver metastases were imaged as hot lesions with only 41% sensitivity and 86% specificity. In 14 patients with other non-colorectal carcinomas, RIS was successful in single cases. It is not helpful, however, when searching for tumours of unknown origin or for the screening of patients with elevated CEA levels without tumour history. The high technical, methodological and time effort required by RIS is justified in the follow-up of cancer patients when conventional diagnostic procedures are inconclusive or the status of morphological findings remains unclear. The use of RIS as an unspecific screening tool in tumour diagnosis must be rejected because of the not completely explored risks of the examination. Repeated applications of monoclonal antibodies require controls of the patients' HAMA titers before performing RIS. (orig.).

  17. The Detection Value Analysis of Tumor Markers CEA,CA125 in Cervical Cancer%肿瘤标记物CEA、CA125在宫颈癌中的检测价值分析

    Institute of Scientific and Technical Information of China (English)

    戴伟萍

    2013-01-01

      目的:探讨肿瘤标记物 CEA、CA125在宫颈癌中的检测的临床价值.方法:选取笔者所在医院2011年1月-2012年8月经临床确诊的100例宫颈癌患者(宫颈癌组)及40例进行健康体检的妇女(对照组)为研究对象,测定两组的血清肿瘤标记物癌胚抗原(CEA)、糖抗原(CA125).结果:宫颈癌组的血清 CEA、CA125含量显著高于对照组(P<0.05).在宫颈癌组中,随着临床分期的增加 CEA、CA125的阳性率逐渐增加,Ⅲ、Ⅳ期较Ⅰ、Ⅱ期显著增加(P<0.05).结论:肿瘤标记物 CEA、CA125在宫颈癌中有较高的诊断价值,可辅助判断宫颈癌的临床分期.%Objective:To investigate the clinical value of tumor markers CEA,CA125 detection in cervical cancer and the significance.Methods:100 cases of cervical cancer (the cervical cancer group )that was clinical diagnosis from January 2011 to August 2012 in author’s hospital and 40 cases of healthy women (the control group) were chosen as the research object,two groups were measured in serum tumor marker carcinoembryonic antigen (CEA),carbohydrate antigens (CA125).Results:Serum CEA,CA125 in the cervical cancer group were significantly higher than those in the control group (P<0.05).In the cervical cancer group, CEA,CA125 positive rate increased gradually along with the clinical stagin,stage Ⅲ,Ⅳ were significantly than istage Ⅰ,Ⅱ (P<0.05).Conclusion:There is a high diagnostic value of the tumor markers CEA,CA125 in cervical carcinoma;they can help judge clinical cervical cancer staging.

  18. Enraizamento de estacas herbáceas de guaranazeiro em diferentes substratos Survival rate of guarana herbaceous cuttings in different substrates

    Directory of Open Access Journals (Sweden)

    Murilo Rodrigues de Arruda

    2007-02-01

    Full Text Available A utilização de sementes na propagação do guaranazeiro propicia alta variabilidade na produtividade e suscetibilidade a doenças, por isto, no Amazonas, recomenda-se a propagação do guaranazeiro por meio do enraizamento de estacas herbáceas de materiais selecionados. Objetivou-se com este trabalho, avaliar o enraizamento, em tubetes, de estacas herbáceas de doze clones de guaranazeiro submetidas a três diferentes substratos. Os clones avaliados foram o BRS 300, BRS 871, BRS 372, BRS 648, BRS 189, BRS 505, BRS 610, BRS 612, BRS 850, BRS 882, BRS 608, BRS 611. Os substratos testados foram uma mistura com base em volume de 50 % de solo + 50 % de esterco de galinha (v/v; 50 % de esterco de galinha + 50 % de carvão moído passado em peneira de 10 mm (v/v e substrato comercial para hortaliças (Plantmax®. O substrato comercial e o esterco de galinha + carvão proporcionaram a maior porcentagem de enraizamento das estacas. O clone BRS Amazonas obteve o maior percentual de enraizamento (88,2 %, enquanto o clone BRS 372, o menor (15 %.The propagation of the guarana plants using seeds is nowadays not recommended because the high variability in the productivity and susceptibility to diseases. The cuttings propagation of a select guarana plant clones is recommended for Amazonas State. The objective of this study was to evaluate the survival rate of cuttings of twelve clones of guaraná in three substrates with three replicates. The evaluated clones were: BRS 300, BRS 871, BRS 372, BRS 648, BRS 189, BRS 505, BRS 610, BRS 612, BRS 850, BRS 882, BRS 608, BRS 611. The growing media tested were 50% of soil + 50% of chicken manure (v/v; 50% chicken manure + 50% sieved powdered charcoal (v/v and a comercial growing media for vegetables (Plantmax®. The comercial growing media and the misture of chicken manure + sieved powdered charcoal substrate produced the higher cuttings survival rate. The clone BRS Amazonas showed the highest percentage of survival

  19. Anti-CEA aptamers labeled with {sup 99m}Tc: encapsulation studies in long-circulating and pH-sensitive liposomes, biodistribution and imaging

    Energy Technology Data Exchange (ETDEWEB)

    Leonel, M.F.V.; Andrade, A.S.R. [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Oliveira, M.C.; Cardoso, V.N.; Barros, A.L.B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Farmacia

    2015-07-01

    Colorectal cancer (CRC) is one of the leading cancers and the carcinoembryonic antigen (CEA) is a tumor marker widely used in diagnosis since it is overexpressed in tumor cells. Acid nucleic aptamers with high affinity and specificity for this antigen become promising molecules for CRC diagnosis by imaging. However, due to the action of nucleases in vivo, they have been investigated for association with liposomes, such as long-circulating and pH-sensitive liposomes (SPHL) that can be destabilized in the tumor region releasing aptamers and contributing to the CRC diagnosis by scintigraphy. In this work, SpHL containing DOPE, CHEMS and mPEG{sub 2000}-DSPE were characterized by analyzing mean diameter, polydispersity index and zeta potential. The anti-CEA aptamers Apt3 and Apt3-Amino were labeled with technetium-99m and the encapsulation efficiency (EE) of {sup 99m}Tc-Apt3 in the SpHL by dehydration-rehydration (modified DRV) and freeze-thaw (FT) were analyzed, both in the presence of cryoprotectants. Biodistribution and scintigraphic images were performed at 1h and 4h post-injection of {sup 99m}Tc-Apt3-amino, {sup 99m}Tc-Apt3-SpHL or {sup 99m}Tc-Apt3-amino-SpHL complexes in Balb/c healthy mice. The SpHL dispersions were homogeneous. The radiolabeling yield with technetium-99m was over 90% for all complexes. By the dehydration-rehydration method, the SpHL increased over 200% after encapsulation procedure. By the freeze-thaw method, the SpHL size increased only 13.7%. Free {sup 99m}Tc-Apt3-amino showed to be cleared by renal via with high levels of radioactivity in the kidney and bladder, however, the {sup 99m}Tc-Apt3-SpHL and {sup 99m}Tc-Apt3-amino-SpHL clearly indicated high uptake by liver and spleen. The biodistribution of {sup 99m}Tc-Apt3-SpHL showed significant uptake of radioactivity by stomach and thyroid indicating less stability of the Apt3 radiolabelling in relation to Apt3-amino. (author)

  20. Clorofíceas marinhas bentônicas da Praia de Serrambi, Pernambuco, Brasil Benthic marine Chlorophyceae from Serrambi Beach, Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Sônia Maria Barreto Pereira

    1998-04-01

    Full Text Available É apresentado o levantamento florístico sobre as clorofíceas marinhas bentônicas encontradas na Praia de Serrambi, litoral Sul do Estado de Pernambuco. O material estudado foi coletado em três estações, as quais foram visitadas mensalmente durante o período de abril de 1986 a setembro de 1987. As clorofíceas foram representadas na flora local por 39 espécies, três variedades e uma forma, pertencentes às ordens Ulotrichales, Ulvales, Siphonocladales, Cladophorales, Caulerpales e Dasycladales. Acetabularia calyculus Quoy & Gaimard. In Freycinet, Bryopsis pennata Lamouroux, Bryopsis plumosa (Hudson C. Agardh, Caulerpa ambigua Okamura, Caulerpa serrulata (Forsskål J. Agardh emend Børgesen, Chaetomorpha brachygona Harvey, Cladophora coelothrix Kützing, Cladophoropsis membranacea (C. Agardh Børgesen, Codium intertextum Collins & Hervey, Ernodesmis verticillata (Kützing Børgesen são novas referências para a flora do litoral de Pernambuco. Pringsheimiella scutata (Reinke von Höhnel ex Marchewianka o é também para o litoral continental do Brasil. Halimeda opuntia (L. Lamouroux foi hospedeira de maior número de epífitas, enquanto Bryopsis plumosa, quando epífita, foi a que cresceu sobre maior número de hospedeiros.This survey presents studies about benthics marine chlorophyceae found in the Serrambi Beach, South coast of Pernambuco. The material studied was collected in three stations, which were visited monthly during the period from April, 1986 to September, 1987. The chlorophyceae were represented in this flora by 39 species, three varieties and one form, from orders Ulotrichales, Ulvales, Siphonocladales, Cladophorales, Caulerpales and Dasycladales. Acetabularia calyculus Quoy & Gaimard. In Freycinet, Bryopsis pennata Lamouroux, Bryopsis plumosa (Hudson C. Agardh, Caulerpa ambigua Okamura, Caulerpa serrulata (Forsskål J. Agardh emend Børgesen, Chaetomorpha brachygona Harvey, Cladophora coelothrix Kützing, Cladophoropsis

  1. CEA在肺癌和其它肺部疾病的表达%Expressions of CEA in Lung Cancer and Other Pulmonic Diseases

    Institute of Scientific and Technical Information of China (English)

    舒仁明; 何思春; 焦鑫; 王利君

    2004-01-01

    目的:探讨血清CEA检测对肺癌的诊断及与其它肺部疾病的鉴别诊断价值.方法:用贝克曼库尔特Access化学发光分析仪及配套试剂盒,测定108例肺癌和115例其它肺疾病患者血清CEA,并检测60例正常人作为对照.结果:肺癌组CEA中位数为85.10ng/ml,其它肺疾1.95 ng/ml,正常人为1.99ng/ml.肺腺癌血清CEA显著高于鳞癌和小细胞肺癌.结论:血清CEA检测有助于肺癌的诊断及与其它肺部疾病的鉴别诊断.

  2. Menstrual Cycle Dependent Variability for Serum Tumor Markers CEA, AFP, CA 19-9, CA 125 and CA 15-3 in Healthy Women

    Directory of Open Access Journals (Sweden)

    Ayşe Binnur Erbağci

    1999-01-01

    Full Text Available Information on menstrual cycle dependent variation of tumor markers in healthy women is a subject of diagnostic efficiency and has an impact in elucidating the normal function of these markers. In this study midfollicular and midluteal concentrations of serum CEA, AFP, CA 19-9, CA 125, CA 15-3 and their relations with LH, FSH, prolactin, estradiol and progesterone were evaluated during ovulatory cycles in a group of 23 healthy female individuals. Samples were collected on the 7th and 21st day of the same menstrual cycle. Tumor marker and hormone concentrations were determined with chemiluminescence or electrochemiluminescence EIA methods. A significant phase-dependent difference was observed for CA 15-3, midluteal concentrations (mean ± SEM; 26.33 ± 1.56 U/ml higher than the midfollicular (mean ± SEM; 19.27 ± 1.49 U/ml concentrations (p < 0.001. But an obvious difference for other tumor markers investigated did not exist. Significant correlations of follicular and luteal CA 125 levels with body mass index of the subjects were observed (r:0.52, p < 0.05 and r:0.57, p < 0.005, respectively.

  3. Las Calamitáceas españolas. Índice taxonómico y clave analítica

    Directory of Open Access Journals (Sweden)

    Diéguez, M. C.

    1986-02-01

    Full Text Available The present work consists of the check-list of the Calamitae para-espcies collected in Spain with the synonims used. These have been compiled in a1phabetical order for case of reference. and is followed by an evaluation of them, considering some elected characters for its rapid identification, with whose we have made one key the para-species, which, helps its determination from the collecting place.

    En el presente trabajo se realiza un índice taxonómico de para-especies de Calamitáceas recogidas en España, con sus principales sinonimias. disponiéndose en orden alfabético para facilitar su utilización. Este índice es seguido por una evaluación de dichas para-especies. en atención a caracteres que faciliten su identificación y a partir de los cuales proponemos una clave analítica, que permita su determinación en el lugar de recogida.

  4. Evaluation of the use of decision-support software in carcino-embryonic antigen (CEA-based follow-up of patients with colorectal cancer

    Directory of Open Access Journals (Sweden)

    Verberne Charlotte J

    2012-03-01

    Full Text Available Abstract Background The present paper is a first evaluation of the use of "CEAwatch", a clinical support software system for surgeons for the follow-up of colorectal cancer (CRC patients. This system gathers Carcino-Embryonic Antigen (CEA values and automatically returns a recommendation based on the latest values. Methods Consecutive patients receiving follow-up care for CRC fulfilling our in- and exclusion criteria were identified to participate in this study. From August 2008, when the software was introduced, patients were asked to undergo the software-supported follow-up. Safety of the follow-up, experiences of working with the software, and technical issues were analyzed. Results 245 patients were identified. The software-supported group contained 184 patients; the control group contained 61 patients. The software was safe in finding the same amount of recurrent disease with fewer outpatient visits, and revealed few technical problems. Clinicians experienced a decrease in follow-up workload of up to 50% with high adherence to the follow-up scheme. Conclusion CEAwatch is an efficient software tool helping clinicians working with large numbers of follow-up patients. The number of outpatient visits can safely be reduced, thus significantly decreasing workload for clinicians.

  5. Nuevas tecnologías desarrolladas para el aprovechamiento de las cactáceas en la elaboración de alimentos. Componentes funcionales y propiedades antioxidantes

    Directory of Open Access Journals (Sweden)

    Mónica Azucena Nazareno

    2011-06-01

    Full Text Available Las cactáceas han sido consideradas por nuestros ancestros y contemporáneos una fuente de alimento y también de medicinas. La mayoría presenta frutos y cladodios comestibles que a su vez pueden ser procesados a una amplia variedad de nuevos productos. Se ha demostrado que su consumo ofrece beneficios nutricionales y promueve la salud, y debido a esto existe un marcado interés en el desarrollo de nuevas tecnologías y la adquisición de nuevos conocimientos sobre su naturaleza química y propiedades para un mejor aprovechamiento, lo que genera nuevos estudios. En tal sentido, en este trabajo se recopiló información de la literatura que fue revisada, con el propósito de aportar una visión general sobre las nuevas tecnologías desarrolladas para el aprovechamiento de los cactus en la elaboración de alimentos con énfasis en sus componentes bioactivos y propiedades antioxidantes. Se concluye que un amplio espectro de nuevas tecnologías está siendo explorado a fin de obtener alimentos cuya función no sea solamente un aporte nutricional sino también que represente un beneficio para la salud de los consumidores.

  6. Nuevas tecnologías desarrolladas para el aprovechamiento de las cactáceas en la elaboración de alimentos. Componentes funcionales y propiedades antioxidantes

    Directory of Open Access Journals (Sweden)

    Mónica Azucena Nazareno

    2011-01-01

    Full Text Available Las cactáceas han sido consideradas por nuestros ancestros y contemporáneos una fuente de alimento y también de medicinas. La mayoría presenta frutos y cladodios comestibles que a su vez pueden ser procesados a una amplia variedad de nuevos productos. Se ha demostrado que su consumo ofrece beneficios nutricionales y promueve la salud, y debido a esto existe un marcado interés en el desarrollo de nuevas tecnologías y la adquisición de nuevos conocimientos sobre su naturaleza química y propiedades para un mejor aprovechamiento, lo que genera nuevos estudios. En tal sentido, en este trabajo se recopiló información de la literatura que fue revisada, con el propósito de aportar una visión general sobre las nuevas tecnologías desarrolladas para el aprovechamiento de los cactus en la elaboración de alimentos con énfasis en sus componentes bioactivos y propiedades antioxidantes. Se concluye que un amplio espectro de nuevas tecnologías está siendo explorado a fin de obtener alimentos cuya función no sea solamente un aporte nutricional sino también que represente un beneficio para la salud de los consumidores.

  7. 腰硬联合麻醉(CSEA)和硬脊膜外麻醉(CEA)在剖宫产术中的比较探讨

    Institute of Scientific and Technical Information of China (English)

    李敏

    2010-01-01

    目的:探讨腰硬联合麻醉(CSEA)和硬脊膜外麻醉(CEA)在剖宫产术中的效果比较.方法:选择我院100例行剖宫产术单胎健康临产妇,随机分为随机分为CSEA和CEA组,每组各50例,观察两组麻醉效果及不良反应.结果:CSEA组SA注药后麻醉平面达到T6时间明显短于EA组;CSEA组的骶神经阻滞不完全率远低于EA组;术中麻醉效果CSEA组明显优于EA组,.最高阻滞平面也有显著性差异.CSEA组有12例(24.0%),CEA组有5例(10.0%).两组低血压发生率有显著性差异.结论:CSEA具有起效快.用药量少,麻醉效果好,可视为急诊剖宫产术的首选麻醉方法,值得临床推广.

  8. Modelos de variación de propiedades del leño juvenil a maduro en Salicáceas y su influencia sobre pulpas quimimecánicas

    OpenAIRE

    Cobas, Ana Clara

    2013-01-01

    En Argentina, la madera de salicáceas (álamos y sauces) es utilizada en diversos usos industriales como madera aserrada, envases y tableros, pero principalmente en la fabricación de pulpa para papel de diario. El rápido crecimiento de las salicáceas produce árboles que alcanzan un tamaño comercial a edades muy tempranas con turnos de aprovechamiento de 10 a12 años. Esta disminución en la edad de rotación incrementa la proporción de leño juvenil, aunque esta proporción no está cuantificada en ...

  9. Uso da capilaroscopia ungueal como método diagnóstico e prognóstico de rosácea Nailfold capillaroscopy as a diagnostic and prognostic method in rosacea

    Directory of Open Access Journals (Sweden)

    Gabriela Poglia Fonseca

    2011-02-01

    Full Text Available FUNDAMENTOS: Não há um método adequado e fidedigno de avaliação e seguimento da severidade na rosácea. OBJETIVO: Determinar a importância da capilaroscopia periungueal como método diagnóstico e prognóstico em pacientes portadores de rosácea. MÉTODOS: Estudo transversal onde foram submetidos ao exame da capilaroscopia periungueal 8 pacientes com rosácea e 8 controles no período entre maio e julho de 2009. Foram coletados dados clínicos relacionados ao sexo, idade, fototipo, classificação da rosácea de acordo com a classificação de Plewig e Kligman e a classificação da National Rosacea Society. Adicionalmente, avaliamos o tempo de evolução da doença e tratamentos previamente utilizados. RESULTADOS: A grande maioria das pacientes avaliadas (6 das 8 pacientes apresentavam rosácea grau I (vascular ou eritêmato-teleangiectásica. A idade média de duração da rosácea foi de 5,96 anos, sendo que 87,5% faziam tratamento com metronidazol tópico. Nenhum paciente tanto do grupo rosácea como controle demonstrou evidência de desvascularização ao exame capilaroscópico. CONCLUSÃO: A capilaroscopia periungueal apresenta um padrão inespecífico e não parece auxiliar no diagnóstico ou prognóstico da rosácea.BACKGROUND: There is no appropriate and reliable method of evaluating and monitoring severity in rosacea. OBJECTIVE: To determine the importance of nailfold capillaroscopy as a diagnostic and prognostic method for patients with rosacea. METHODS: A cross-sectional study where eight patients with rosacea and 8 control subjects were submitted to nailfold capillaroscopy from May to July 2009. We collected clinical data related to gender, age, skin phototype, and rosacea stage according to Plewig and Kligman classification and the classification of the National Rosacea Society. Additionally, we evaluated the progression of the disease and treatment therapies previously used. RESULTS: The majority of the patients evaluated (6

  10. PRODUÇÃO DE MUDAS DE VIDEIRA 'RUBI' PELO MÉTODO DE ENXERTIA DE MESA EM ESTACAS HERBÁCEAS DOS PORTA-ENXERTOS IAC 313 'TROPICAL' E IAC 766 'CAMPINAS'

    Directory of Open Access Journals (Sweden)

    REZENDE LEILA DE PAULA

    2001-01-01

    Full Text Available Com o objetivo de estudar o método de enxertia de mesa em estacas herbáceas para a obtenção de mudas de videira, experimentos foram desenvolvidos em câmara de nebulização, localizada no ripado do Departamento de Produção Vegetal da Faculdade de Ciências Agrárias e Veterinárias da UNESP, no período de novembro de 1997 a dezembro de 1999. Foram utilizadas estacas herbáceas dos porta-enxertos IAC 313 'Tropical' e IAC 766 'Campinas' e borbulhas e garfos da cultivar Rubi. Foram testados os métodos de enxertia de garfagem em fenda cheia e de borbulhia em placa, em estacas herbáceas sem raízes e enraizadas, o tipo de proteção do enxerto, o tamanho das estacas e o recipiente de enraizamento. Foram avaliados o enraizamento e o pegamento de enxertos. O método de enxertia de mesa com garfagem e com proteção do enxerto com saco plástico apresentou maior pegamento de enxerto aos 30 (45,25% e 60 dias (66,20% após a enxertia. O tamanho da estaca não afetou o pegamento dos enxertos. Contudo, em todos os experimentos, o índice de sobrevivência dos enxertos foi muito baixo ou nulo. Estacas sem enxertia proporcionaram maior porcentagem de enraizamento (65,62% em relação às estacas enxertadas. O método de enxertia de mesa em estacas herbáceas dos porta-enxertos IAC 313 'Tropical' e IAC 766 'Campinas' não foi eficiente para a formação de mudas de videira.

  11. The evaluation of the year 1999. Report of the Safety Administrative Staff; Bilan 1999. Le rapport de la Direction centrale de la securite. Controle des rejets et surveillance de l'environnement des centres CEA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The environmental quality around the CEA's Centers is a constant care of its safety policy. In this context a continuously control of the effluents and the air is monitoring. In order to inform the public this report presents the evaluation of the liquid or gaseous radioactive effluents, for the year 1999. A part is devoted to the regulations and the methods used to control the environmental quality around the centers. (A.L.B.)

  12. Achado incidental de glândula sebácea em colo uterino: provavelmente um processo metaplásico An incidental finding of sebaceous glands in the uterine cervix: a probable metaplastic process

    Directory of Open Access Journals (Sweden)

    Daniel Cury Ogata

    2012-06-01

    Full Text Available As glândulas sebáceas ectópicas são achados muito infrequentes no trato genital feminino. Descrevemos um caso que ocorreu em paciente de 42 anos de idade, submetida à histerectomia total, devido à leiomiomatose e ao prolapso uterino.The ectopic sebaceous glands have been extremely rare findings in female genital system. We describe the case of 42 years-old patient with total hysterectomy due to leiomyomatosis and uterine prolapsed.

  13. Overview of CEA studies on hydrogen production and related prospects for nuclear power; Vue d'ensemble des etudes du CEA sur la production d'hydrogene et des perspectives de l'energie nucleaire dans ce domaine

    Energy Technology Data Exchange (ETDEWEB)

    Agator, J.M. [CEA Saclay, DSE/SEE, 91 - Gif-sur-Yvette (France); Guigon, A. [CEA Cadarache, Dept. d' Etudes des Reacteurs, 13 - Saint-Paul-lez-Durance (France); Serre-Combe, P. [CEA Grenoble, Direction des Technologies Avancees/Cerem/DEM/SPCM, 38 (France)

    2001-07-01

    The anticipated growth of the world energy demand and the increasing concern about the emission of greenhouse gases, with the objectives of limitation fixed by the Kyoto protocol, prepare the ground for the development of hydrogenous fuels, and especially that of hydrogen as energy carrier. The trend will be reinforced in the longer term with the progressive shortage of natural hydrocarbon fuels. Fuel cells used in stationary, transport and portable applications will probably be the most efficient hydrogen converter and the most promising decentralized energy technology of the next decades. In order to contribute to the reduction of greenhouse gas emissions, a massive use of hydrogen for transport and stationary applications calls for the development of production processes compatible with low CO{sub 2} emissions, thus limiting the use of fossil fuels (natural gas, oil, coal...) as reagent or energy sources. Furthermore, the progressive exhaustion of economic fossil fuel reserves will ultimately make it necessary to extract hydrogen from water through CO{sub 2} free processes. With this prospect in view, base-load nuclear energy, besides renewable energies, can play an important role to produce hydrogen through electrolysis in the medium term, and also through high temperature thermochemical water dissociation processes in the longer term. Starting from current research in the field of fuel cans and hydrogen storage systems, the CEA intends to implement a large R and D programme on hydrogen also covering the aspects of production, transport and related safety requirements. This endeavour is intended to reinforce the contribution of the CEA to the national and European research effort on non-fossil energy sources, and to open new opportunities of international collaborations and networking. (authors)

  14. Polyethylene glycol (PEG) linked to near infrared (NIR) dyes conjugated to chimeric anti-carcinoembryonic antigen (CEA) antibody enhances imaging of liver metastases in a nude-mouse model of human colon cancer.

    Science.gov (United States)

    Maawy, Ali A; Hiroshima, Yukihiko; Zhang, Yong; Luiken, George A; Hoffman, Robert M; Bouvet, Michael

    2014-01-01

    We report here that polyethylene glycol (PEG) linked to near infrared dyes conjugated to chimeric mouse-human anti-carcinoembryonic antigen (CEA) antibody greatly improves imaging of liver metastases in a nude mouse model of colon-cancer experimental metastases. PEGylated and non-PEGylated DyLight 650 and 750 dyes were conjugated to the chimeric anti-CEA antibody. The dyes were initially injected intravenously into nude mice without tumors. Tissue biodistribution was determined by tissue sonication and analyzing tissue dye concentration profiles over time. PEGylated dyes had significantly lower accumulation in the liver (p = 0.03 for the 650 dyes; p = 0.002 for the 750 dyes) compared to non-PEGylated dyes. In an experimental liver metastasis model of HT-29 colon cancer, PEGylated dyes conjugated to the anti-CEA antibody showed good labeling of metastatic tumors with high contrast between normal and malignant tissue which was not possible with the non-PEGylated dyes since there was so much non-specific accumulation in the liver. PEGylation of the DyLight 650 and 750 NIR dyes significantly altered tissue biodistribution, allowing brighter tissue labeling, decreased accumulation in normal organs, particularly the liver. This enabled high fidelity and high contrast imaging of liver metastases.

  15. Polyethylene glycol (PEG linked to near infrared (NIR dyes conjugated to chimeric anti-carcinoembryonic antigen (CEA antibody enhances imaging of liver metastases in a nude-mouse model of human colon cancer.

    Directory of Open Access Journals (Sweden)

    Ali A Maawy

    Full Text Available We report here that polyethylene glycol (PEG linked to near infrared dyes conjugated to chimeric mouse-human anti-carcinoembryonic antigen (CEA antibody greatly improves imaging of liver metastases in a nude mouse model of colon-cancer experimental metastases. PEGylated and non-PEGylated DyLight 650 and 750 dyes were conjugated to the chimeric anti-CEA antibody. The dyes were initially injected intravenously into nude mice without tumors. Tissue biodistribution was determined by tissue sonication and analyzing tissue dye concentration profiles over time. PEGylated dyes had significantly lower accumulation in the liver (p = 0.03 for the 650 dyes; p = 0.002 for the 750 dyes compared to non-PEGylated dyes. In an experimental liver metastasis model of HT-29 colon cancer, PEGylated dyes conjugated to the anti-CEA antibody showed good labeling of metastatic tumors with high contrast between normal and malignant tissue which was not possible with the non-PEGylated dyes since there was so much non-specific accumulation in the liver. PEGylation of the DyLight 650 and 750 NIR dyes significantly altered tissue biodistribution, allowing brighter tissue labeling, decreased accumulation in normal organs, particularly the liver. This enabled high fidelity and high contrast imaging of liver metastases.

  16. DIAGNOSTIC VALUE OF SERUM VEGF, CEA AND NSE IN DIAGNOSIS OF NON-SMALL CELL LUNG CANCER%血清VEGF、CEA、NSE在非小细胞肺癌诊断中应用价值研究

    Institute of Scientific and Technical Information of China (English)

    郑立平; 林海峰

    2011-01-01

    [目的]探讨血清血管内皮生长因子(VEGF)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)在非小细胞肺癌(NSCLC)诊断中的应用价值,旨在为肺癌的诊治提供理论参考.[方法]采用ELISA方法测定100例NSCLC患者和50例健康查体者血清VEGF、CEA、NSE水平,并分析其与病理分型和临床分期的关系.[结果]肺癌组血清CEA、NSE、VEGF水平均显著高于对照组,相比较差异有统计学意义(P<0.05);鳞癌患者血清CEA和NSE水平显著高于腺癌,相比较差异有统计学意义(P<0.05);而血清VEGF水平在鳞癌和腺癌患者中差异无统计学意义(P>0.05);血清VEGF、CEA、NSE水平随着临床分期的递增而显著上升,其血清水平为Ⅳ期>Ⅲ期>I~Ⅱ期,3组之间比较差异有统计学意义(P<0.05).[结论]联合检测肺癌患者血清中VEGF、CEA、NSE水平的变化,对NSCLC的早期诊断和鉴别具有重要的临床价值.%[Objective] To explore diagnostic value of serum vascular endotbelial growth factor (VEGF), earcinoembry-onic antigen (CEA) and neuron-specific enolase (NSE) for diagnosis of the non-small cell lung cancer (NSCLC), and to provide theoretical reference for diagnosis and treatment of NSCLC. [Methods] 100 cases of patients with NSCLC and 50 cases of healthy people were determined by ELJSA, and their relationship with pathological type and clinical stage were analyzed. [ Results ] The serum CEA, NSE and VEGF levels of the lung cancer group were significantly higher than that of control group, the difference was significant (P 0.05); The serum VEGF, CEA and NSE levels significantly increased with increasing clinical stage, the difference was significant among the three groups (P< 0.05). [Conclusion] Combined detection of the serum VEGF, CEA and NSE levels has important clinical value for the early diagnosis and diagnosis of NSCLC.

  17. 乳腺癌病人外周血中Mammaglobin、CEA、P53的表达及其意义%Significance of the expression of mammaglobin,CEA,P53 in peripheral blood of breast cancer patients

    Institute of Scientific and Technical Information of China (English)

    李传应; 陈柯; 顾平

    2011-01-01

    Aim To detect the expression of mammablogin,CEA, P53 in peripheral blood of the patients of breast cacer, and to explore the relationship between mammaglobin and the occurrence and the development of breast cancer. Methods The expression of mammaglobin , CEA , P53 were detec:ted in peripheral blood of normal tissue of breast , breast cancer of insitu and breast cancer by using RT-PCR ,and the expression of mammaglohin was compared with CEA, p53. Results Of 14 cases of breast cacinamo patients,10 cases highly expressed mammaglobin , CEA , P53 in peripheral blood , wihle 4 cases did not 2 cases of in siut cacinoma highly expressed, while all 4 cases of benign breast disease did not highly express these three markers. Conclusion Mammaglobin is a specific marker of the hreast cancer.which has colse relation to breast cancer. Mammaglobin together with CEA and P53 will be markers of early dignosis and prognosis of breast cancer.%目的 通过检测乳腺癌患者外周血中mammaglobin、CEA、P53的表达情况,mammaglobin、CEA、P53与乳腺癌发生、发展的关系.方法 使用实时PCR(realtime RT-PCR)方法检测正常乳腺组织、乳腺原位癌、浸润性乳腺癌患者的外周血中mammaglobin、CEA、P53的表达,并将mammaglobin的表达情况与后两者进行对比.结果 14例乳腺癌病人外周血中10例mammalobin、CEA、P53高表达,4例无异常表达;3例原位癌中有2例高表达,1例无异常表达;4例乳腺纤维腺瘤、乳腺病病人外周血中mammalobin、CEA、P53均无异常表达.结论 mammaglobin是乳腺癌的特异性标志物,与乳腺癌的发生有密切的关系,mammaglobin结合CEA、P53联合检测可能会成为乳腺癌患者早期诊断及判断乳腺癌患者预后的特异性标记物.

  18. Sensitivity of Symptomatology Versus Diagnostic Procedures and Concentration of CEA and CA19–9 in the Early Detection of Colorectal Cancer

    Science.gov (United States)

    Vukobrat-Bijedic, Zora; Husic-Selimovic, Azra; Bijedic, Nina; Mujkic, Admir; Sofic, Amela; Gogov, Bisera; Mehmedovic, Amila; Bjelogrlic, Ivana; Glavas, Sanjin; Djuran, Aleksandra

    2014-01-01

    Introduction: Colorectal cancer is the major diagnostic and therapeutic problem. The number of patients in the world has increased recently. In our country it is detected late and patients visit doctor in the advanced stage of the disease with already developed metastases. Material and methods: A clinical study was conducted at the Clinic of gastroenterohepatologists, Clinical Center of Sarajevo University on 164 patients. Special attention was given to the symptoms, which are considered to be a macroscopically visible as bleeding, anemia pain, weight loss and disturbance of defecation. Smoking had no effect because a small number of observed patients smoked. Endoscopic examination revealed localization of the tumor in the colon and then underwent targeted biopsy, histological analysis by pathologist, and we determined the concentration of CEA and CA19-9 in the serum. Results: In order to get the most relevant results we used larger data set. The program used to prepare the data was Microsoft Excel 2013, and for the creation of decision trees is a used software RapidMiner version 5. Our research has shown that patients older than 55 years with significant stenosis, metastasis and diarrhea that lasted longer than 3.5 months and bleeding that lasted up to 10 months had cancer of the rectum. Bleeding that lasts longer than 10 months indicated that it was the case of cancer that was localized in the rectum in men and sigma in women. Patients older than 82.5 years and had diarrhea up to 3.5 months developed cancer in the sigma part of the colon. Analyzing pain as a symptom of an alarm, the study found that pain that lasts longer than a few days, is caused by rectal cancer, and occurs after the age of 70.5 years, and in patients younger than 63 years anemia as a alarm symptom, which lasted more than two months in men was caused by cancer of the rectum and in women cancer in other localizations within colon. In patients without stenosis developed bleeding as the most

  19. Volumen y dimensiones como predictores del peso de semilla en especies herbáceas del centro de la Península Ibérica

    Directory of Open Access Journals (Sweden)

    Sánchez, Ana M.

    2001-12-01

    Full Text Available Although seed weight is a key factor in understanding the reproductive biology of plant species, its value is unknown for a large proportion of the herbaceous species in the Mediterranean basin. This paper presents data on seed weight, dimensions and volume for 1 18 herbaceous species in acidic Mediterranean scrub and grassland in the centre of the Iberian Peninsula. This information is used to design predictive models of seed weight using multiple regression models. taking into account the phylogenetic effect. Five groups of models were designed: one using Trifolium species. three. using the families represented by the largest number of species (Catyophyllaceae, Asteraceae and Poaceae; and finally a general model using one species from each of the families present in the sample. The models are rated according to the absorbed variante, their significance in relation to the previous in complexity and the effort required to obtain the data for each one. We also test the validity of seed dimension data taken from literature sources to predict seed weight. The 1-0 seed dimensions are excellent weight predictors in the case of Trifolium (Weight = - 24.55 + 0.10D1 + 3.38D2, r2 = 0.94 and Asteraceae (Weight = - 20.90 + 1.19D1 + 1.67D2, r2 = 0.91 and are quite satisfactory in the case of the general model (Weight = - 16.01 +0.56D1 + 1.6002, r2 = 0.69.El peso de las semillas es un carácter clave para entender la biología reproductiva de las especies vegetales, pero se desconoce su valor para gran parte de las especies herbáceas de la cuenca mediterránea. En este trabajo se exponen datos de peso, dimensiones y volumen de las semillas de 118 especies herbáceas características del matorral y pastizal acidófilos mediterráneos del centro de la Península Ibérica. Esta información es empleada para elaborar modelos predictivos del peso a partir de las dimensiones mediante el uso de modelos de regresión lineal múltiple, teniendo en cuenta el efecto

  20. Differential diagnosis of tuberculosis and lung cancer pleural effusion by CEA, CA125,CA50%CEA、CA125、CA50在结核及肺癌性胸水鉴别中的意义

    Institute of Scientific and Technical Information of China (English)

    冯金栋; 赵卫国; 保鹏涛

    2013-01-01

    Objective:To explore the significance of differential diagnosis of pleural effusion by detection of carci-noembryonic antigen (CEA) ,carbohydrate antigen (CA125) and carbohydrate antigen (CA50). Methods: A total of 126 specimens from pleural effusion diagnosed as TB in 70 cases and lung cancer in 56 cases were collected. CEA, CA125,CA50 in the pleural effusion were analyzed. ResuItS:The expression level and sensitivity of CEA and CA50 in pleural effusion of lung cancer was significantly higher than that in tuberculous (P 0.05). The specificity was only 5.71%. Combining CEA with CA125 to diagnose pleural effusion resulted fom lung cancer, the sensitivity was 92. 11% and combining CA125 with CA50 the sensitivity was 95. 24% . When the concetration of CEA was more than 10ng/ml or the concetration of CA125 was more than 2000U/ml,pleural effusion of lung cancer should be highly suspected. Conclusion;The use of CEA.CA125 and CA50 separately,or in combination is helpful to differential diagnosis of pleural effusion resulted from tuberculosis and lung cancer.%目的:探讨癌胚抗原(CEA)、糖类抗原(CA125)、糖类抗原(CA50)在胸水鉴别诊断中的意义.方法:收集已明确胸水性质的标本126例(结核性70例、癌性56例),检测胸水中CEA、CA125、CA50的数值,进行统计分析.结果:肺癌性胸水中CEA、CA50表达水平及敏感度明显高于结核性胸腔积液(P<0.05),特异性分别为95.71%和98.57%.同样CA125在肺癌性胸水中高表达(P<0.05),但两组敏感度无差异(P>0.05),特异性仅为5.71%;CEA和CA125联合诊断肺癌性胸水的敏感度为92.11%,CA125和CA50联合诊断敏感度为95.24%.CEA> 10ng/ml或CA125> 2000U/ml,可初步定为肺癌性胸水.结论:CEA、CA125、CA50单独或联合检测对鉴别诊断结核及肺癌性胸水有重要临床指导意义.

  1. Comportamento de espécies herbáceas em misturas de solo com diferentes graus de contaminação com metais pesados

    Directory of Open Access Journals (Sweden)

    Carneiro Marco Aurélio Carbone

    2002-01-01

    Full Text Available O objetivo deste trabalho foi avaliar, em casa de vegetação, o comportamento de espécies herbáceas em relação ao excesso de Cd e Zn no solo. O gradiente de contaminação foi estabelecido a partir de mistura de solo contaminado com solo sem contaminação em diferentes proporções. As sementes foram semeadas em tubetes contendo 250 mL de solo, e após 90 dias as plantas foram colhidas e avaliadas. A maioria das espécies apresentou redução no crescimento com aumento da contaminação do solo e elevadas concentrações de Cd e Zn na matéria seca da parte aérea (MSPA, na mistura com 15% de solo contaminado. A espécie Pffafia sp. mostrou-se tolerante à contaminação, crescendo em misturas de solo contendo até 90 mg kg-1 de Cd e 1.450 mg kg-1 de zinco. Além disso, apresentou concentração superior a 100 mg kg-1 de Cd na MSPA, sendo considerada hiperacumuladora desse metal. Sida glaziovii, Bidens pilosa, Rhynchelytrum repens, Cenchrus echinatus e Nicandra physaloides, por sua vez, foram severamente afetadas pela contaminação, ao contrário de Trifolium repens, Euchlaena mexicana, Cynodon dactylon, Avena strigosa, Cenchrus ciliares e Cyperus sp. que apresentaram crescimento satisfatório. As espécies avaliadas mostram-se promissoras para estudos adicionais sobre a reabilitação de áreas contaminadas com metais pesados.

  2. Estudio de las comunidades de plantas herbáceas de las Islas Bonaerenses del Bajo Delta del Río Paraná (Argentina

    Directory of Open Access Journals (Sweden)

    Patricia Kandus

    2003-01-01

    Full Text Available El sector bonaerense del Bajo Delta del Río Paraná conforma un extenso humedal costero de agua dulce sometido a mareas (2.700 km2. El presente trabajo se propuso identificar y describir las comunidades de herbáceas nativas de las islas y proponer un modelo conceptual que permita interpretar la expresión espacial de las mismas. Se partió de la hipótesis de que el régimen hidrológico y el patrón de paisaje son los factores principales que determinan la heterogeneidad de la región y condicionan la presencia y abundancia de las especies y comunidades vegetales. En 21 sitios de muestreo se realizaron un total de 177 censos en los que se identificaron 62 especies, se estimó la abundancia-cobertura por especie y se tomaron muestras de suelo. Se delimitaron 19 comunidades vegetales que conforman un mosaico heterogéneo, se caracterizan por su baja riqueza específica y la dominancia de unas pocas especies de tipo graminoide y en menor medida de latifoliadas. La presencia diferencial de las comunidades en la región y su composición específica se relacionó con dos factores principales de variación. El primero fue la permanencia del agua relacionado con la posición topográfica de los censos, el segundo correspondió al grado de conexión de las comunidades con los cursos de agua principales y por su localización con relación al macrogradiente de influencia fluvial-estuárica regional

  3. Evaluación de la actividad repelente de aceites esenciales de plantas Piperáceas del departamento de Chocó, Colombia

    Directory of Open Access Journals (Sweden)

    BE Jaramillo-Colorado

    2015-01-01

    Full Text Available El objetivo de este trabajo fu e determinar la composición química volátil del aceite esencial de varias especies de Piper áceas ( Piper dilatatum, Piper aduncum, Piper divaricatum, Piper sp, Piper sanctifelicis y la actividad repelente de ellos contra el gorgojo de granos almacenados Tribolium castaneum Herbst. Los aceites esenciales se obtuvieron por hidrodestilación, la separación e identificación de los component es volátiles se realizó por cromatografía de gases acoplada a espectrometría de masas y par a la evaluación de la activ idad repelente se empleó el método de áre a de preferencia. Los compuestos m ayoritarios encontrados en Piper dilatatum fueron el apiol 89,0% y trans -cariofileno (3,5%; en Piper divaricatum, eugenol (37,5% y metil eugenol (36,3%; Piper sp,  - gurjuneno (o guaieno (24,9% y elemol (14,2%; Piper sanctifelicis,  -3-careno (35,3% y limoneno (27,1%; Piper aduncum , dilapiol (48,2% y 1,8 cineol (11,4%. Los porcentajes de repelencia de los aceites esenciales a una concentración de 1 μ L/cm 2 , a un tiempo de exposición de 2 horas frente al T. castaneum fueron: Piper aduncum (99%, Piper sp (96%, Piper dilatatum (82%, Piper divaricatum (76%, Piper santifelicis (33%.

  4. Seletividade do herbicida fluazifop-p-butil para cucurbitáceas Selectivity of the herbicide fluazifop-p-buthyl for cucurbitaceae

    Directory of Open Access Journals (Sweden)

    R.A. Vidal

    2000-01-01

    Full Text Available Experimentos foram conduzidos em condições de casa de vegetação, com o objetivo de avaliar a seletividade do herbicida fluazifop-p-butil nas doses de 0, 94, 188, 376 e 752 g i.a. ha-1 para cinco espécies de cucurbitáceas (abobrinha, melancia, melão, moranga e pepino. Foi determinada a fitotoxicidade aos 14 dias após a aplicação dos tratamentos (DAT. Aos 20 DAT foram avaliadas a estatura, área foliar e matéria seca. O melão e o pepino mostraram sensibilidade ao fluazifop-p-butil na maior dose estudada, com maior intensidade no melão. Os resultados demonstraram que existe resposta a estes herbicidas mesmo dentro da classe Dicotiledoneae. Especula-se que essas respostas possam auxiliar no entendimento do completo mecanismo de ação desse herbicida.Experiments were conducted under greenhouse conditions to evaluate the selectivity of the herbicide fluazifop-p-buthyl at rates of 0, 94, 188 and 752 g a.i. ha-1 for five cucurbitaceous species (summer squash, watermelon, melon, pumpkin and cucumber. Plant injury at 14 days after treatments (DAT and plant size, leaf area and dry weight at 20 DAT were determined. Melon and cucumber were susceptible to fluazifop-p-buthyl at the highest rate with highest herbicide effect being observed on melon. These results indicated that responses to these herbicides occur, even in the Dicotiledonae class. These responses are thought to help understand the overall mechanism of action of this herbicide.

  5. Analysis on the value of combined detection of CYFRA21-1,NSE,CEA,CA125 in lung carcinoma%CYFRA21-1、NSE、CEA 和CA125联合检测对肺癌诊断的价值分析

    Institute of Scientific and Technical Information of China (English)

    陈乐

    2016-01-01

    Objective To investigate the value of combined detection by using tumor markers cytokeratin‐19 fragment antigen (CYFRA21‐l) ,neuron‐specific enolase (NSE) ,carcinoembryonic antigen (CEA) and carbohydrate cancer antigen 125(CA125) in lung cancer diagnosis .Methods 200 people who treated in the hospital in related departments from January 2012 to January 2014 were enrolled in the study .100 of them suffered from lung cancer ,53 suffered from benign lung disease ,the rest 47 were healthy people .Electrochemiluminescence method or enzyme‐linked immunosorbent assay(ELISA) were used to detect serum tumor mark‐ers CYFRA21‐1 ,NSE ,CEA ,CA125 and the sensitivity ,specificity and accuracy of different combinations of test items were evalua‐ted .Results In the single detection of those tumor markers for the diagnosis of lung cancer ,CYFRA21‐1 detection got the highest sensitivity and accuracy ,while CA125 got the highest specificity(95 .0% ) .The sensitivity and specificity of combined detection were both significantly higher than single detections .The sensitivity ,pecificity and accuracy of the combined detection of the 4 tumor markers were 92 .0% ,72 .0% ,and 87 .0% respectively .Conclusion In the clinical diagnosis of lung cancer ,the combined detection of several serum tumor markers get higher sensitivity and accuracy than single detection ,which is worthy of clinical promotion .%目的:探讨细胞角蛋白‐19片段抗原(CYFRA21‐1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA )和糖类癌抗原125(CA125)联合检测对肺癌患者的诊断价值。方法从2012年1月至2014年1月该院相关科室共选取研究对象200例,其中肺癌患者100例、肺良性病变患者53例、健康体检者47例。采用电化学发光方法或酶联免疫吸附测定(ELISA )检测患者血清CYFRA21‐1、NSE、CEA、CA125的水平,评价不同检测项目组合在肺癌诊断中的灵敏度、

  6. Compliance and Enforcement Actions (CEA) -

    Data.gov (United States)

    Department of Transportation — Compliance and Enforcement Actions application provides process assistance / improvements for conducting investigation and enforcement activities. The Compliance and...

  7. Enxertia herbácea em Myrtaceae nativas do Rio Grande do Sul Herbaceans grafiting in native Myrtaceae on Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Daiane Silva Lattuada

    2010-12-01

    Full Text Available O objetivo deste trabalho foi testar a viabilidade da técnica de enxertia herbácea em frutíferas nativas da família Myrtaceae. O experimento foi realizado em casa de vegetação do Departamento de Horticultura e Silvicultura/ UFRGS, em Porto Alegre. Duas espécies de Myrtaceae nativas foram usadas, tanto como porta-enxerto quanto como enxerto, Eugenia uniflora (Pitangueira e E. involucrata (Cerejeira-do-rio-grande ou Cerejeira-do-mato, totalizando quatro combinações. O método de enxertia adotado foi por garfagem em fenda cheia, em ramos herbáceos, com diâmetro médio do porta-enxerto de 0,1cm, enquanto os ramos dos enxertos apresentavam diâmetro médio entre 0,08 a 0,1cm, para as duas espécies. As análises foram quinzenais e, após 70 dias, foram analisadas estatisticamente a pega e a altura média das brotações emitidas. O delineamento experimental foi o completamente casualizado, com quatro repetições, sendo cada unidade experimental composta de cinco enxertos. Os resultados indicaram pega de 60% na combinação Pitangueira-Pitangueira (porta enxerto - enxerto. As demais combinações mostraram-se ineficientes.The objective of this study was to test the viability of the technique of green grafting in natives Myrtaceae. The experiment was conducted in greenhouse conditions of the Departamento de Horticultura e Silvicultura / UFRGS, in Porto Alegre. Two species of Myrtaceae were used, as well as rootstock and as graft, Eugenia uniflora (Surinam cherry and E. involucrata (Rio-grande-cherry or Cherry of the woods, totaling four combinations. The adopted grafting method consisted to cleft the graft on herbaceous branches, with an average diameter of the rootstock of 0.1 cm, while the branches of the grafts had an average diameter between 0.08 to 0.1 cm for both species. The observations were carried out every two weeks, and after 70 days were statiscally analyzed. The experimental design was completely randomized with four

  8. Cinemática de la extensión jurásica vinculada a la Provincia Silícea Chon Aike, Santa Cruz, Argentina

    Directory of Open Access Journals (Sweden)

    María S. Japas

    2013-03-01

    Full Text Available La Provincia Silícea Chon Aike, de vasta distribución en Patagonia, plataforma continental y Península Antártica, representa un megaevento volcánico ocurrido en tiempos jurásicos (188-152 Ma, cuyo emplazamiento estuvo controlado por una tectónica extensional. El análisis cinemático llevado a cabo a partir de fallas y zonas de cizalla frágil-dúctil en cuatro localidades (El Dorado- Monserrat, Norte de Cerro Vanguardia y El Fénix, en la comarca del Deseado; y Lago Ghío, en la Cordillera Patagónica Austral, permitió definir los ejes cinemáticos de la deformación jurásica, reconocer dos eventos cinemáticos diferentes (principal y secundario e identificar la existencia de un régimen transtensional. En relación a la oblicuidad que presentan los ejes cinemáticos en estas localidades, se definieron en forma preliminar dos dominios: el oriental y el occidental. El dominio oriental (El Dorado - Monserrat, Norte de Cerro Vanguardia presenta una dirección de extensión ENE para el evento principal y NNO para el evento secundario, mientras que el dominio occidental (El Fénix y Lago Ghío exhibe direcciones de extensión NE y NO para los episodios principal y secundario, respectivamente. Estos eventos cinemáticos diferentes (principal y secundario guardan estrecha correlación con facies volcánicas definidas, ya que el episodio secundario se encuentra temporalmente restringido al momento del emplazamiento de la facies efusiva riolítica (domos, coladas, cuerpos hipabisales. Dado el marcado diacronismo de esta provincia volcánica, las diferencias estructurales y cinemáticas halladas entre ambos dominios podrían estar reflejando un emplazamiento controlado por estructuras desarrolladas progresivamente que, a escala continental, estarían vinculadas a un régimen de deformación no-coaxial mayor.

  9. Fontes de resistência em melancia aos principais potyvírus isolados de cucurbitáceas no Nordeste brasileiro

    Directory of Open Access Journals (Sweden)

    Oliveira Vanuzia B. de

    2002-01-01

    Full Text Available A melancia, Citrullus spp., pode ser infetada por várias espécies de vírus, dentre as quais se destacam as pertencentes à família Potyviridae. Visando identificar fontes de resistência a potyvírus, foi iniciado na UFC um programa de indexação do banco de germoplasma de melancia da Embrapa Semi-Árido. Foram utilizadas as espécies de potyvírus, isoladas de cucurbitáceas no Nordeste: Papaya ringspot virus type W (PRSV-W; Watermelon mosaic virus-2 (WMV-2 e Zucchini yellow mosaic virus (ZYMV. Dos 50 acessos de melancia avaliados, 37 pertencem a Citrullus lanatus, 9 a C. lanatus var. citroides e 4 a C. colocynthis. Em casa-de-vegetação foram inoculadas 4 plantas envasadas de cada acesso com PRSV-W, 4 com WMV-2 e 4 com ZYMV, ficando 4 sem inoculação. As inoculações foram efetuadas 8 dias após o plantio, e 15 dias depois. As plantas assintomáticas foram reinoculadas. As plantas que persistiram sem sintomas, após um período de 25 dias após a primeira inoculação, foram testadas por ELISA contra os anti-soros correspondentes. Dentre os acessos avaliados, 5 mostraram-se resistentes aos 3 vírus, um resistente somente ao PRSV-W, 21 resistentes somente ao ZYMV e nenhum com resistência isolada ao WMV-2. No entanto, 45 acessos apresentaram resistência ao ZYMV isoladamente ou em combinação com outro potyvírus. Os acessos suscetíveis, apresentaram sintomas 10 dias após a primeira inoculação enquanto que os resistentes permaneceram sem sintomas após a segunda inoculação e com resultados negativos em ELISA. Alguns acessos poderão ser cruzados visando obter populações segregantes para a seleção de indivíduos homozigotos recessivos e, juntamente com os acessos com resistência tripla identificados, ampliar a variabilidade genética de fontes quanto a características de planta e fruto.

  10. Caldera La Peligrosa (47º15´S, 71°40´O: un evento clave en la Provincia Silícea Chon Aike

    Directory of Open Access Journals (Sweden)

    Patricia Sruoga

    2010-05-01

    Full Text Available En el área ubicada entre el lago Ghío y la sierra Colorada, en la Cordillera Patagónica Austral, aflora una secuencia piroclástico- lávica de carácter proximal correspondiente al Complejo El Quemado, de edad jurásica tardía. A partir del análisis integrado de litofacies y estructuras se llevó a cabo la reconstrucción de la arquitectura volcánica. Se han reconocido cuatro litofacies ignimbríticas y una litofacies lávico-hipabisal de composición riolítica, cuyo emplazamiento estuvo controlado por un sistema de fallas transtensionales de orientación NNO predominante. Se propone un modelo de evolución de la caldera La Peligrosa en tres etapas:1 pre-colapso, durante la cual se define una zona dilatante propicia para la formación de la caldera, con incipiente fallamiento en bloques, 2 colapso, cuando ocurre el emplazamiento de potentes ignimbritas cristalinas y megabrechas en una cubeta de subsidencia progresiva, controlada por un régimen transtensional con dirección de extensión NE y 3 post-colapso, durante la cual se produce el derrame de lavas junto con la intrusión de cuerpos dómicos, bajo condiciones de extensión oblicua con dirección de extensión NO. El pasaje de un ambiente transtensional a condiciones de extensión oblicua acompañó las últimas etapas del desarrollo de la caldera representando un notable cambio en las condiciones de la deformación en tiempos jurásicos. La formación y desarrollo de la caldera La Peligrosa puede ser considerada como un evento clave para entender los mecanismos eruptivos del vasto volcanismo ignimbrítico de la Provincia Silícea Chon Aike.

  11. Proceedings of the 1989 CESAR/CEA (Center for Engineering Systems Advanced Research/Commissariat a l'Energie Atomique) workshop on autonomous mobile robots (May 30--June 1, 1989)

    Energy Technology Data Exchange (ETDEWEB)

    Harber, K.S.; Pin, F.G. (Oak Ridge National Lab., TN (USA). Center for Engineering Systems Advanced Research)

    1990-03-01

    The US DOE Center for Engineering Systems Advanced Research (CESAR) at the Oak Ridge National Laboratory (ORNL) and the Commissariat a l'Energie Atomique's (CEA) Office de Robotique et Productique within the Directorat a la Valorization are working toward a long-term cooperative agreement and relationship in the area of Intelligent Systems Research (ISR). This report presents the proceedings of the first CESAR/CEA Workshop on Autonomous Mobile Robots which took place at ORNL on May 30, 31 and June 1, 1989. The purpose of the workshop was to present and discuss methodologies and algorithms under development at the two facilities in the area of perception and navigation for autonomous mobile robots in unstructured environments. Experimental demonstration of the algorithms and comparison of some of their features were proposed to take place within the framework of a previously mutually agreed-upon demonstration scenario or base-case.'' The base-case scenario described in detail in Appendix A, involved autonomous navigation by the robot in an a priori unknown environment with dynamic obstacles, in order to reach a predetermined goal. From the intermediate goal location, the robot had to search for and locate a control panel, move toward it, and dock in front of the panel face. The CESAR demonstration was successfully accomplished using the HERMIES-IIB robot while subsets of the CEA demonstration performed using the ARES robot simulation and animation system were presented. The first session of the workshop focused on these experimental demonstrations and on the needs and considerations for establishing benchmarks'' for testing autonomous robot control algorithms.

  12. Composição e distribuição dos Crustácea (Decapoda na Lagoa do Peixe, Rio Grande do Sul, Brasil Composition and distribution of Crustácea (Decapoda from Lagoa do Peixe, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Sandro Santos

    2000-03-01

    Full Text Available The Lagoa do Peixe ("Peixe's Lagoon" is located between Atlantic Ocean and Lagoa dos Patos and is 30 Km long and 0,5-2,0 Km wide (31º13'S, 50º55'W -31º26'S, 51º09'. For one year, the composition and distribution of Crustácea Decapoda were analyzed monthly (from July/1994 to June/1995, in seven subareas (terrestrial border and aquatic area and physical and chemical parameters (depth, salinity, sediment texture, oxygen in water, organic material of sediment and water temperature were registered. Decapoda from the families Grapsidae, Ocypodidae, Portunidae (Brachyura, Diogenidae (Anomura and Penaeidae (Penaeidea were captured. Chasmagnathus granulata Dana 1851 was found ali months near the canal connecting Atlantic Ocean and Lagoa do Peixe, but inside the lagoon it was collected only in October/94 and June/95, and in extreme subareas it was sampled in February/95 when the salinity was 31 ‰ at these sites. Callinectes sapidus Rathbun, 1896 and Cyrtograpsus angulatus Dana, 1851 were captured throughout the year, except October/94 and April/95, respectively. Both species were found in ali áreas of sample, indicating a high plasticity in relation to the factors analyzed in this study. Another species captured probably come in the lagoon in specific months, when the environment provides ideal conditions for their develo-pments.

  13. Evaluación de siete tipos de vegetales herbáceas cultivadas en acuaponia usando el efluente del cultivo de tilapia (Oreochromis niloticus x O. aureous) en condiciones salobres.

    OpenAIRE

    Campos Pulido, Rosa

    2013-01-01

    Los objetivos de este estudio fueron caracterizar fisicoquímicamente un efluente salobre de cultivo de tilapia en producción comercial, evaluar el crecimiento de siete especies vegetales herbáceas en acuaponia y conocer criterios para seleccionar plantas de acuerdo a las características del efluente. El diseño experimental fue completamente al azar. Los datos se analizaron mediante estadística descriptiva y análisis de varianza. Para comparar las medias de los parámetros evaluados se realizó ...

  14. Utilización de aguas regeneradas para el riego de dos especies de la familia de las mirtáceas (Myrtus Communis L. y Eugenia Myrtifolia L.

    OpenAIRE

    2014-01-01

    [ESP] La investigación realizada evalúa la posibilidad de la reutilización de aguas residuales de distinta calidad, que previamente han sido depuradas (ARD), para el riego de dos especies de la familia de las Mirtáceas (Myrtus communis L. y Eugenia myrtifolia L.) empleadas con usos y fines ornamentales. Las aguas utilizadas en este trabajo tienen una composición que varía estacionalmente ya que presentan orígenes distintos, aunque tienen en común que son aguas más o menos salinas: ARD1 (CE = ...

  15. Prognostic value of carcinoembryonic antigen distribution in tumor tissue of colorectal carcinoma Valor prognóstico da distribuição do antígeno carcinoembriônico (CEA no tecido neoplásico do carcinoma colorretal

    Directory of Open Access Journals (Sweden)

    Débora Maria Nazato

    2009-03-01

    Full Text Available CONTEXT: Carcinoembryonic antigen (CEA can be detected in colorectal tumor tissue but its role in the survival of patients remains controversial. OBJECTIVE: To characterize the expression of tissue CEA using immunohistochemical staining in colorectal tumors and to analyze the relationship between this finding and preoperative plasmatic level of CEA, morphologic features and survival of patients operated with curative intent for colorectal carcinoma. METHOD: Forty-seven patients were included in the study: 18 (38.3% males and 29 (61.7% females, with a mean age of 67.8 ± 9.7 years (37 to 84 years. Immediately before laparotomy, pre-operative serum levels of CEA were obtained where normal levels were considered CONTEXTO: O antígeno carcinoembrionário (CEA pode ser detectado no tecido do carcinoma colorretal, mas seu papel na sobrevivência dos doentes permanece controverso. OBJETIVO: Caracterizar a expressão do CEA tecidual com coloração imunoistoquímica na neoplasia colorretal e analisar a relação entre esse achado e os níveis plasmáticos pré-operatórios do CEA, aspectos morfológicos e a sobrevivência dos doentes operados com intenção curativa de carcinoma colorretal. MÉTODO: Quarenta e sete doentes foram incluídos neste estudo: 18 (38,3% homens e 29 (61,7% mulheres, com média de idade de 67,8 ± 9,7 anos (37 to 84 anos. Imediatamente antes da laparotomia, foram obtidos os níveis plasmáticos pré-operatórios do CEA. Níveis séricos pré-operatórios normais de CEA foram considerados < 2,5 ng/mL para não-fumantes e <5,0 ng/mL para fumantes. O estudo imunoistoquímico do CEA foi realizado utilizando anticorpo monoclonal de rato anti-CEA humano. A expressão da imunocoloração de cada neoplasia foi classificada de acordo com o padrão de distribuição tecidual do CEA em apical ou citoplasmática. As variáveis consideradas para a análise estatística foram os níveis plasmáticos pré-operatórios do CEA, localização da

  16. Heparinoides naturais isolados de rodofíceas (Halymenia sp. arribadas na costa cearense =Natural heparinoids isolated from Halymenia sp. (Rhodophyceaes delivery on the Ceará coast

    Directory of Open Access Journals (Sweden)

    José Ariévilo Gurgel Rodrigues

    2010-07-01

    Full Text Available A crescente carência de heparina (HEP motiva a busca por fontes alternativas de novos anticoagulantes naturais. Objetivou-se avaliar a atividade anticoagulante dos polissacarídeos sulfatados (PS isolados de uma rodofícea do gênero Halymenia, nativa do litoral cearense, Brasil. Os PS totais foram obtidos por digestões consecutivas com papaína em tampão acetato de sódio 0,1 M (pH 5,0, contendo cisteína 5 mM e EDTA 5 mM, seguidas por cromatografia de troca iônica em coluna de DEAE-celulose. As frações obtidas foram concentradas por liofilização e submetidas à eletroforese em gel de agarose a 0,5%. Os ensaios anticoagulantes foram realizados pelo tempo de tromboplastina parcial ativada (TTPA, usando-se plasma de coelho e uma curva padrão de HEP (100 UI mg-1. As extrações (53,96% mostraram diferenças marcantes durante o fracionamento e no grau de resolução dos PS. A espécie apresentou PS com atividade anticoagulante superior a HEP. O TTPA das frações modificou-se acentuadamente entre as extrações, expressando-se de maneira dose-dependente e sofrendo um acréscimo de 110,40 (1a extração para 143,10 UI mg-1 (3a extração. Os resultados sugerem que a atividadeanticoagulante dos PS isolados de Halymenia sp. foi promovida pela inibição da via intrínseca e/ou comum da cascata de coagulação. As modificações no TTPA possivelmente serão elucidadas pelos mecanismos de ação envolvidos na coagulação e caracterização estrutural desses compostos. Portanto, a rodofícea Halymenia sp. é uma boa fonte de heparinoides e sugerem-se estudos relacionados ao cultivo da espécie, em proteção aos bancos de algas.The increasing demand for heparin (HEP has led to a search for alternative sources of natural anticoagulants. This study aimed to evaluate the anticoagulant activity of sulfated polysaccharides (SP isolated from a Halymenia rhodophyceae genus native to the coast of Ceará, Brazil. Total SP were obtained by consecutive

  17. 反转录-聚合酶链反应检测华蟾素对晚期胃癌患者外周血癌胚抗原信使核糖核酸表达的作用%RT-PCR detecting CEA mRNA expression in peripheral blood of advanced gastric cancer patients treated by Cinobufo-talin

    Institute of Scientific and Technical Information of China (English)

    吴志雄; 易升明

    2013-01-01

    Objective To analyze the application value of peripheral blood carcinoembryonic antigen messen-ger ribonucleic acid(CEA mRNA) in the diagnosis of the hematogenous metastasis of gastric cancer ,and to evalu-ate the therapeutic effect of the anti-cancer traditional Chinese herb “Cinobufotalin” on gastric cancer .Methods Phase Ⅲb-Ⅳ stage of advanced gastric cancer patients were randomly divided into treatment group and control group .Both group were treated with 2 cycles of chemotherapy :Gimeracil and Oteracil Porassium Capsules were taken orally for 80 mg · m -1 · d-1 ,twice a day after breakfast and dinner for 14 d ,rested 7 d ,and 3 weeks as a cycle .At the same time ,Cinobufacini injection of 20 mL+5% GS 500 mL was used in the treatment group once a day for 14 days .RT-PCR was used to determine the CEA mRNA in peripheral blood before and after the adminis-tration of drugs .Results Before the therapy with“Cinobufotalin” ,the positive rates of CEA and CEA mRNA in experimental group were 34% and 62% ,respectively ,and that in control group were 32% and 58% ,respective-ly .After the therapy with“Cinobufotalin” ,the positive rates of CEA and CEA mRNA in experimental group were 28% and 49% ,respectively ,and that in control group were 27% and 44% ( P>0 .05) .A significant difference of the contents of CEA and CEA mRNA before and after the treatment was shown in the experimental group ( P<0 .05) .A significant difference of the contents of CEA mRNA after the treatment was shown between both group ( P <0 .05) ,which is contrary to the contents of CEA .Conclusion It is perhaps an ideal method to detect the micrometastasis of gastric cancer through the evaluation of expression of CEA mRNA in the peripheral blood by reverse transcription PCR (RT-PCR) .It may play an important role in the evaluation of the prognosis and the ne-cessity of adopting advanced therapy among the gastric cancer patients . Anti-cancer traditional Chinese herb“Cinobufotalin” is

  18. Selección de rizobacterias por su antagonismo frente a microorganismos patógenos de cucurbitáceas /Screening of rhizobacteria for their antagonism against microbial pathogens of cucurbits.

    Directory of Open Access Journals (Sweden)

    Gilda Jiménez Montejo

    2014-04-01

    Full Text Available Resumen:El desarrollo de inoculantes microbianos a partir de aislamientos de rizobacterias con potencial para el control biológico de enfermedades de los cultivos agrícolas requiere de una rigurosa selección. Se obtuvieron aislamientos bacterianos de la rizosfera de papa (Solanum tuberosum L. y de maíz (Zea mays L. y de semillas de frijol (Phaseolus vulgaris L.. Las colonias que mostraron in vitro halos de inhibición de los patógenos de cucurbitáceas: Xanthomonas cucurbitae, Acidovorax avenae subsp. citrull y Fusarium oxysporum, se seleccionaron como antagonistas. A partir de las características morfológicas, fisiológicas y bioquímicas las cepas antagonistas F16/95 y Xph se identificaron con la especie Bacillus subtilis y la cepa 14A como Pseudomonas putida. Las pruebas presuntivas de producción de antibiocinas in vitro sugirieron modos de acción de las rizobacterias relacionados con antibiosis y competencia por el hierro mediante la producción de sideróforos. Los resultados indicaron el potencial de las cepas de rizobacterias antagonistas Bacillus subtilis (F16/95, Xph y Pesudomonas putida 14A para el control biológico de enfermedades de las cucurbitáceas./Abstract:

  19. Ultrasensitive electrochemical immunoassay for CEA through host-guest interaction of β-cyclodextrin functionalized graphene and Cu@Ag core-shell nanoparticles with adamantine-modified antibody.

    Science.gov (United States)

    Gao, Jian; Guo, Zhankui; Su, Fengjie; Gao, Liang; Pang, Xuehui; Cao, Wei; Du, Bin; Wei, Qin

    2015-01-15

    A novel non-enzymatic immunoassay was designed for ultrasensitive electrochemical detection of carcino-embryonic antigen (CEA) using β-cyclodextrin functionalized Cu@Ag (Cu@Ag-CD) core-shell nanoparticles as labels and β-cyclodextrin functionalized graphene nanosheet (CD-GN) as sensor platform. CD-GN has excellent conductivity which promoted the electric transmission between base solution and electrode surface and enhanced sensitivity of immunosensor. In addition, owing to supramolecular recognition of CD-GN for the guest molecule, quite a few synthesized adamantine-modified primary antibodies (ADA-Ab1) were immobilized on the CD-GN by supramolecular host-guest interaction between CD and ADA. Cu@Ag-CD as a signal tag could be captured by ADA-modified secondary antibody (ADA-Ab2) through a host-guest interaction, leading to a large loading of Cu@Ag nanoparticles with high electrical conductivity and catalytic activity. The fabricated immunosensor exhibits excellent analytical performance for the measurement of CEA with wide range linear (0.0001-20 ng/mL), low detection limit (20 fg/mL), good sensitivity, reproducibility and stability, which provide an enormous application prospect in clinical diagnostics.

  20. Diatomáceas epilíticas de águas oligotróficas e ácidas do Sudeste do Brasil Epilithic diatoms from acidic and oligotrophic waters in Southeast Brazil

    Directory of Open Access Journals (Sweden)

    Luís Gustavo de Castro Canani

    2011-03-01

    Full Text Available Poucos estudos tem abordado a flora de diatomáceas de sistemas oligotróficos do Brasil. São apresentados os resultados da composição taxonômica e distribuição espacial e temporal de diatomáceas no rio do Salto, situado no Parque Estadual do Ibitipoca, Minas Gerais (21º40'-21º44'S e 43º52'-43º55'W. As águas desse rio possuem pH entre 4,2 e 5,5 e concentração de ortofosfato entre 1,37 e 10,98 µg.L-1. O estudo baseia-se na análise de 80 amostras coletadas em oito estações no leito rochoso do rio, em janeiro e julho de 2004, períodos de chuva e estiagem, respectivamente. Um total de 15 espécies e duas variedades taxonômicas, distribuídas em oito gêneros e oito famílias foram descritas e ilustradas, com destaque para o gênero Eunotia Ehrenberg. O estudo sobre diatomáceas bentônicas em ambientes lóticos é pioneiro no estado de Minas Gerais, sendo registradas 14 novas citações, das quais Fragilariforma stevensonii Metzeltin & Lange-Bertalot, Eunotia pirarucu Metzeltin & Lange Betalot, Nupela giluwensis Vyverman & Compère e Sellaphora blackfordensis Mann & Droop são primeiros registros para o Brasil.Few studies have been done on the diatom flora of acidic and oligotrophic environments from Brazil. We present the taxonomic composition and distribution of diatoms of Salto River, situated at Ibitipoca State Park, Minas Gerais (21º40'-21º44'S; 43º52'-43º55'W. The pH values ranged from 4.2 to 5.5 and orthophosphate was between 1.37 and 10.98 µg.L-1. The study is based on the analysis of 80 samples collected at eight stations in the rocky stream bed, in January and July 2004, rainy and dry seasons, respectively. A total of 15 species and two taxonomic varieties distributed in eight genera and eight families were described and illustrated, notably the Eunotia Ehrenberg genus. The study of benthic diatoms in lotic systems is pioneer in Minas Gerais state; 14 new records were recorded of which Fragilariforma stevensonii

  1. Fijación biológica de nitrógeno por tres fabáceas (Leguminosae en suelos ácidos de Tabasco, México

    Directory of Open Access Journals (Sweden)

    S. Córdova-Sánchez

    2011-01-01

    Cajanus cajan L., Canavalia ensiformis L. y Mucuna deerengiana L., en rotación y asociación con maíz durante dos ciclos de cultivo, se desarrollaron dos experimentos en un suelo ácido de la sabana de Huimanguillo, Tabasco. En ambos sistemas se evaluaron variables relacionadas con la nodulación de estas fabáceas, así como su efecto sobre el rendimiento de maíz (Zea mays L.; también se cuantificó el N derivado de la atmósfera (Fbn y la eficiencia de absorción de N por el cultivo de maíz a través de la técnica isotópica de 15N. Los resultados muestran que C. cajan L., produjo 66 a 121, C. ensiformis L., 38 a 80 y M. deerengiana L., 45 a 78 nódulos planta-1, con una ms máxima de 14, 7 y 4 g planta-1 en asociación como en rotación, respectivamente. La producción de biomasa por las fabáceas fue de 5,780 para C. cajan L., 7,037 para C. ensiformis L., y 5,284 kg ha-1 para M. deerengiana L., en asociación con maíz. El rendimiento de grano de los diferentes genotipos de maíz en rotación y asociación varió entre 580 a 642 kg ha-1 durante dos ciclos de estudio. El N fijado por estas fabáceas en rotación se considera muy bajo (2 kg N ha-1; mientras que ocurrió mayor fijación en la asociación fabaceae-maíz (135 kg N ha-1, pero la alta dosis de Fbn no repercutió en mayor rendimiento de grano respecto a los testigos.

  2. Efeito do ácido indolbutírico e raizon no enraizamento de estacas herbáceas e lenhosas de umbuzeiro = Effect of indolbutiric acid and raizon in the rooting of herbaceous and hardwoody cuttings of umbu tree

    Directory of Open Access Journals (Sweden)

    Luciane Arantes de Paula

    2007-07-01

    Full Text Available O umbuzeiro pode ser propagado assexuadamente, mas poucas informações se tem de que a espécie pode ser propagada por estaquia. Diante disso, o objetivo do trabalho foi avaliar o efeito de diferentes concentrações de AIB (ácido indolbutírico e do Raizon 05® no enraizamento de estacas herbáceas e lenhosas de umbuzeiro. Utilizou-se o delineamento experimental em bloco ao acaso, com quatro concentrações de AIB (0; 500; 1000 e 2000 mg L-1 e uma de Raizon 05® e dois tipos de estacas (herbácea e lenhosa. As estacas foramtratadas com Metiltiofan (Thiophanate methyl a 0,05% i.a. por um minuto, em seguida foram imersas nas soluções de AIB por dez minutos ou em contato com Raizon 05®. Realizou-se o plantio em tubetes plásticos contendo vermiculita média. O material permaneceu em telado com 50% de redução de luz, com nebulização intermitente. As variáveis analisadas foram: porcentagem de sobrevivência, enraizamento e massa seca das raízes. Pode-se concluir que: as estacas lenhosas apresentaram melhores resultados em relação às estacas herbáceas para a sobrevivência; o maior percentual de enraizamento foi verificado em estacas herbáceas com a aplicação de 500 mg L-1 de AIB, proporcionando33,33% de estacas enraizadas.The umbu tree can be propagated assexually, but few information are had that the species can be propagation by cutting. The objective of the present research was to evaluate the effect of different concentrations of IBA (indolbutiric acid and Raizon 05® in the rooting of cuttings herbaceous and hardwoody of umbu tree. The experimental design used was block at random, with four concentrations of IBA (0; 500; 1000 and 2000 mg L-1 and one of Raizon 05® and two types of cuttings (herbaceous and hardwoody. After the treatment of the cuttings with Metiltiofan (Thiophanate methyl a 0,05% i.a. for one minute, these were immersed in the solutions of IBA by ten minutes, or in contact with Raizon 05®, soon afterwards took

  3. Comunidades de monocotiledôneas herbáceas e pteridófitas terrestres e suas relações com o ambiente em mata de galeria no Parque Nacional de Brasília

    OpenAIRE

    Souza, Andrielle Cristine Medeiros de

    2016-01-01

    Matas de galeria são áreas florestais associadas a cursos d’água. A composição florística e a estrutura do componente herbáceo em matas de galeria são pouco conhecidas, o mesmo ocorre em relação à influência das variações ambientais e espaciais nessas comunidades. O componente herbáceo dessas matas é formado principalmente por monocotiledôneas e samambaias. O objetivo deste trabalho foi determinar o efeito do ambiente e do espaço na composição de monocotiledôneas herbáceas e samambaias terres...

  4. Is geographical rarity frequent among the cacti of the Chihuahuan Desert? ¿Es la rareza geográfica frecuente entre las cactáceas del Desierto Chihuahuense?

    Directory of Open Access Journals (Sweden)

    Héctor M. Hernández

    2010-04-01

    Full Text Available With the aim of assessing the extent of geographical rarity of Mexican Cactaceae, we calculated the distribution size (area of occupancy of 142 species from the Chihuahuan Desert. In addition, using 2 variables (number of localities and range size, we preliminarily assessed their conservation status using the current IUCN Red List criteria. The results showed enormous variation in the areas of occupancy, although from the biogeographic and conservation perspective the most exceptional group comprises the extremely narrow endemics (42 species, whose range is restricted to areas smaller than 10 km2. Our results reinforce the reputation of this plant family as exceptionally rare geographically. We suggest that geographical rarity of Cactaceae in the Chihuahuan Desert is a natural phenomenon; however, we propose that the range of several species has been influenced by human activities. Regarding the conservation status of the species, 75 of them are categorized as Least concern. The remaining 67 species (47.2% fall in 1 of the 3 categories of threat (27 Vulnerable, 11 Endangered, and 29 Critically endangered. These figures confirm the critical conservation status of Mexican Cactaceae.Se calculó el tamaño de la distribución (área de ocupación de 142 especies de cactáceas del Desierto Chihuahuense, con el objeto de evaluar su grado de rareza geográfica. Además, mediante el uso de 2 variables (número de localidades y tamaño de distribución, se estimó de manera preliminar su estado de conservación usando los criterios actuales de la Lista Roja de la UICN. Los resultados mostraron gran variación en las áreas de ocupación. Sin embargo, desde una perspectiva biogeográfica y de la conservación, el grupo de especies más excepcional corresponde a las endémicas restringidas (42 spp., cuyas áreas de distribución son menores de 10 km². Los resultados fortalecen la reputación de las cactáceas de ser una familia de plantas excepcionalmente

  5. Correlational study on the levels of serum CA153 and CEA and bone metastases of breast cancer%血清CA153、CEA水平与乳腺癌骨转移的相关性研究

    Institute of Scientific and Technical Information of China (English)

    黎秀月; 张军一; 陈晓华; 陈旭坚; 曹小龙; 陈逢生; 罗荣城

    2012-01-01

    Objective To explore the predictive value of serum tumor levels of carbohrdyate antigen (CA) 153 and carcinoembryonic antigen (CEA) for bone metastases of breast cancer patients. Methods The serum levels of CA153 and CEA in 39 patients were determined before and after diagnosis of bone metastases by enzyme linked immunosorbent assay (ELISA). Results Serum levels of CA153 and CEA before and after metastases showed significant differences, which also showed significant correlation with bone metastases. Serum levels of CA153 in patients with human epidermal growth factor receptor 2 (HER - 2) ( - ), before menopause, stage Ⅲ - IV and bone metastatic regions>5 showed significant differences afier metastases (p5, ectosteal bone metastatic region5, epidermal receptor (ER)( - ), ER( + ), PR(-), PR( + ) were significantly increased, and showed significant correlation with bone metastases ( P < 0.05). Conclusion The increase of tumor serum levels of CA153 and CEA is correlated with the bone metastases of breast cancer and it is thus of predictive value.%目的 探索血清肿瘤标志物CA153、CEA对乳腺癌患者骨转移的预测价值.方法 采用酶联免疫吸附法,测定39例乳腺癌患者骨转移前后肿瘤标志物CA153、CEA的血清水平.结果 骨转移前后血清CA153、CEA水平有显著性差异,且与乳腺癌骨转移有显著的相关性.HER-2(-)、绝经前、Ⅲ~Ⅳ期、骨转移区域数>5乳腺癌患者骨转移后CA153水平显著升高(P<0.05).HER-2( -)、Ⅲ~Ⅳ期、骨转移区域数>5、骨外转移区域数<1、PR阴性乳腺癌患者血清CA153水平与骨转移有显著相关性(P<0.05).HER-2(-)、绝经后、Ⅱ期、滑转移区域数≤5、骨外转移区域数>5、ER阴性、ER阳性、PR 阴性、PR阳性乳腺癌患者,骨转移后CEA水平升高,且与骨转移有显著相关性(P<0.05).结论 血清肿瘤标志物CA153、CEA水平升高与乳腺癌骨转移有一定的相关性,对乳腺癌骨转移有一定的预测价值.

  6. ESTUDO COMPARATIVO ENTRE TÉCNICAS DE DETERMINAÇÃO DA MATÉRIA ORGÂNICA EM EFLUENTES INDUSTRIAIS DE COMPOSIÇÃO CARBONÁCEA

    OpenAIRE

    2012-01-01

    Neste trabalho é feita uma avaliação frente à precisão e exatidão de diversas técnicas analíticas para a quantificação da matéria orgânica em efluentes de características tóxicas e biodegradáveis, de origem carbonácea. O trabalho consistiu no desenvolvimento de soluções sintéticas de sacarose (componente presente em efluentes de industriais de alimentos) e de fenol (componente tóxico presente em efluentes petroquímicos). Foram realizadas avaliações destas soluções quanto aos níveis de repetib...

  7. Análise do custo-benefício da avaliação ocular de pacientes portadores de rosácea Cost-benefit analysis of ocular examination of patients with rosacea

    Directory of Open Access Journals (Sweden)

    Keila Barbosa de Oliveira Lima

    2005-02-01

    Full Text Available OBJETIVO: Observar as principais manifestações oculares de pacientes portadores de rosácea e avaliar o custo-benefício dos exames diagnósticos realizados. MÉTODOS: Vinte pacientes com acne rosácea do Ambulatório de Dermatologia da Universidade Federal de São Paulo (UNIFESP foram entrevistados por meio de um questionário, submetidos ao exame oftalmológico e aos testes de Schirmer I, fluoresceína, rosa Bengala, citologia de impressão e raspado conjuntival. O levantamento de custos destes exames foi feito a partir da tabela do Sistema Único de Saúde (SUS, medicina de grupo (AMB 90 e valores cobrados no serviço particular. RESULTADOS: De um total de 20 pacientes que iniciaram o estudo, 16 compareceram a todas as consultas. Houve predomínio do sexo feminino (55%, raça branca (95% e a média de idade foi de 56 anos. Todos os pacientes apresentaram sinais e sintomas clínicos e os principais foram: prurido (40%, lacrimejamento (35%, sensação de corpo estranho (30%, embaçamento visual (25%, telangiectasia palpebral (70%, hiperemia palpebral (70%, meibomite (65%, blefarite (50%. Os exames subsidiários realizados mostraram-se, em sua maioria, dentro da normalidade. Houve diferença no levantamento de custos das diferentes fontes pagadoras. CONCLUSÕES: As principais manifestações oculares de pacientes portadores de rosácea foram sinais e sintomas relacionados com disfunção das glândulas de Meibomius. Considerando os custos dos exames realizados e os resultados obtidos, concluímos que a consulta oftalmológica é a que apresenta melhor custo-benefício para o paciente portador de rosácea.PURPOSE: To observe the main ocular manifestations of patients with rosacea and to evaluate the cost-benefit of supplementary diagnostic examinations. METHODS: Twenty patients with acne rosacea from the Dermatology Service of the São Paulo Federal University (UNIFESP were interviewed through a questionnaire, submitted to ophthalmologic

  8. The value of ADA and CEA in the diagnosis of benign and malignant chest and abdominal dropsy%ADA和CEA在诊断良性恶性胸腹水中的价值

    Institute of Scientific and Technical Information of China (English)

    陈敏; 杨昕; 徐利萍

    2006-01-01

    目的探讨胸腹水腺苷脱氨酶(ADA)和癌胚抗原(CEA)联合检测在鉴别诊断良恶性胸腹水中的价值.方法应用酶偶联测定法对20例结核性胸腹水、25例癌性胸腺水3例细菌性胸腹水进行胸腹水ADA(PADA)和血清ADA(SADA)测定,并同时检测胸腹水CEA和血清CEA.结果结核性胸腹水ADA活性及PADA/SADA比值均超过癌性和细菌性胸腹水(P<0.01).以PADA>40 U/L为诊断结核性胸腹水界限,其诊断率为85.0%,特异性为92.8%.以PADA/SADA>1为结核性胸腹水诊断界限,其诊断率为95.0%,特异性为96.4%.CEA在癌性胸腹水中的诊断率为88.0%,特异性为91.3%.在血清中的诊断率为28.0%.均超过结核性和细菌性胸腹水(P<0.01).结论胸腹水ADA和CEA的测定对诊断良恶性胸腹水有一定的价值.

  9. Logistic回归和ROC曲线评价甲胎蛋白、癌胚抗原和糖链抗原19-9在肝癌诊断中的价值%The value of assessing AFP and CEA and CA19 -9 by using logistic regression and ROC curve in the diagnosis of liver cancer

    Institute of Scientific and Technical Information of China (English)

    戴大飞; 陈晓鹏

    2016-01-01

    目的 探讨应用Logistic回归和ROC曲线综合评价甲胎蛋白( AFP)、癌胚抗原( CEA)和糖链抗原19-9(CA19-9)在肝癌诊断中的价值. 方法 采用电化学发光原理测定AFP、CEA、CA19-9. 检测126例肝癌患者(肝癌组)、75例肝病患者(肝病组) ,通过ROC曲线分析AFP、CEA、CA19-9及三种肿瘤标志物联合检测的Logistic回归结果的ROC曲线值( AUC值). 结果 肝癌-肝良性疾病者中,除CEA外,其余2种肿瘤标志物均有显著性(P0.05). 在肝癌-肝良性疾病中,AUC( AFP) >AUC ( CA19-9)>AUC( CEA);三种肿瘤标志物联合检测的AUC值均高于三项肿瘤标志物单一检查的AUC.结论 联合检测血清AFP、CEA、CA19-9对肝癌具有较高的诊断价值,联合检测三种肿瘤标志物可提高肝癌的诊断率.%Objective To explore the value of assessing AFP and CEA and CA19 -9 by logistic regression and ROC curve in the diagnosis for liver cancer.Methods Serum AFP, CEA and CA19-9 ( using CLIA) levels were measured in 126 patients with liver cancer, 75 patients with benign liver disorders.The area under the ROC curves ( AUC ) of AFP, CEA and CA19 -9 from logistic regression results was compared.Results The serum concentrations of AFP and CA19 -9 in liver cancer patients were higher than those in patients with benign liver diseases (P0.05).In cancer-benign disorder group, the AUC of AFP was larger than the AUC of CA199.the AUC of CA19-9 was larger than the AUC of CEA.AUC value of AFP, CEA and CA19-9 combination detection was larger than AUC value of AFP, CEA and CA19-9 single detection.Conclusions The combination detection of serum AFP, CEA and CA19-9 have higher diagnostic value in liver cancer, also can improve the diagnosis rate of liver cancer.

  10. Enxertia de maracujazeiro-azedo em estacas herbáceas enraizadas de espécies de passifloras nativas Grafting of passion fruit on rooted-herbaceous cuttings of wild passiflora species

    Directory of Open Access Journals (Sweden)

    Renata da Costa Chaves

    2004-04-01

    Full Text Available As doenças provocadas por patógenos do solo em maracujazeiro constituem-se em um dos principais problemas para essa cultura no Brasil. Uma das alternativas de controle dessas doenças seria a utilização de porta-enxertos resistentes. Várias espécies de passifloras nativas vêm apresentando resistência a essas doenças, mas a utilização destas como porta-enxertos oriundos de sementes tem sido dificultada pelas diferenças de diâmetro entre o porta-enxerto e o enxerto da espécie comercial, o que não aconteceria caso fossem utilizadas as estacas herbáceas como porta-enxerto. No presente experimento, utilizaram-se estacas herbáceas retiradas da parte mediana de ramos de plantas de Passiflora setacea (acesso EC-PS 1, P. nitida (acesso EC-PN 1, P. caerulea (acesso EC-PC 1, P. actinia (acesso EC-PA 1 e de um híbrido F1 entre P. setacea x P. edulis f. flavicarpa comercial e tratadas com ácido naftaleno acético (ANA a 500 mg/L e mantidas em câmaras de nebulização. As enxertias do tipo "garfagem lateral no topo" foram efetuadas aos 40; 55 e 70 dias após a coleta e plantio das estacas, utilizando garfos de uma única planta de maracujazeiro-azedo. As avaliações foram efetuadas aos 145 e 150 dias após o plantio das estacas, determinando-se a porcentagem de pegamento da enxertia e de enxertos brotados e o comprimento do broto do enxerto. A produção de mudas por enxertia em estacas herbáceas enraizadas de Passiflora nitida e do híbrido F1 (P. setacea x P. edulis f. flavicarpa foi tecnicamente viável.The soil born diseases cause expressive losses in passion fruit crops in Brazil. The use of resistant rootstocks is an alternative to control these diseases. Several wild species of Passifloraceae have presented resistance to soil born pathogens, but their utilization as rootstock from seeds has been limited mainly by differences of thickness between the rootstock and the graft of the commercial cultivars. These limitations could be

  11. Construction of Eukaryotic Expression Vector with Rana Antimicrobial Peptides Gene Temporin-lCEa%中国林蛙抗菌肽Temporin-1CEa基因的真核表达载体构建。

    Institute of Scientific and Technical Information of China (English)

    张志崇; 王春生; 张秋婷; 朴善花; 苗向阳; 安铁洙

    2012-01-01

    In order to establish a method to get a large number of antimicrobial peptides from Rana chensinensis,a series of experiments were conducted as follows.According to Chinese frog skin antimicrobial peptides Temporin-1CEa gene mRNA sequence(EU624139) in GenBank,a pair of specific primers were designed and cDNA was obtained from Chinese forest frog skin RNA by reverse transcription.Temporin-1CEa gene coding sequence was amplified using the cDNA,and linked with pEASY-T3 cloning vector.The GFP gene was inserted into the recombinant plasmid Tem-T3 by molecular methods.The Tem-GFP fragment was linked with eukaryotic expression vector pcDNA3.1,and Tem-GFP-pcDNA3.1 recombinant plasmid was achieved finally.Using of lipid infection method,the plasmids were transfected into sheep fibroblast cells,the green fluorescence was observed under a fluorescence microscope after 48 h.qPCR data showed that Tem-GFP fusion protein expression level of transfected Tem-GFP-pcDNA3.1 sheep fibroblasts increased about 300 folds than that of the control group.This study supplied the technical basis for developing mammary gland bioreactor of expressing Temporin-1CEa gene.%为了建立大量获取中国林蛙抗菌肽的方法,根据GenBank中的中国林蛙皮肤抗菌肽Temporin-1CEa基因的mRNA序列(EU624139)设计一对特异性引物,以提取的中国林蛙皮肤总RNA反转录出的cDNA为模板,将扩增的编码序列与pEASY-T3克隆载体连接获得Tem-T3;利用酶切、连接等分子生物学手段,将GFP基因连入Tem-T3克隆载体,再经酶切获得Tem-GFP片段,并插入真核表达载体pcDNA3.1,最终得到Tem-GFP-pcD-NA3.1重组质粒;利用脂质体转染法将该质粒转入绵羊成纤维细胞,48 h后可在荧光倒置显微镜下观察到GFP的绿色荧光表达;qPCR数据分析显示,与对照组相比,转染Tem-GFP-pcDNA3.1的绵羊成纤维细胞中融合蛋白Tem-GFP的表达量可提高约300倍。本研究为构建Temporin-1CEa基因山羊乳腺特异表达载体提供依据。

  12. Combined detection of CEA, CA19-9 and CA125 in the differential diagnosis of benign and malignant ascites%联合检测CEA、CA19-9和CA125对鉴别良恶性腹水的价值

    Institute of Scientific and Technical Information of China (English)

    卢冰贤; 周云英

    2011-01-01

    目的 探讨检测CEA(癌胚抗原)、CA19-9(糖类抗原19-9)和CA125(糖类抗原125)对鉴别良、恶性腹水的临床价值. 方法 化学发光法检测120例患者腹水CEA、CA19-9和CA125的含量. 结果 化学发光法检测恶性腹水中的CEA、CA19-9和CA125分别为(37±16) ng/ml、(236±78) U/ml和(602士211)U/ml,良性腹水分别为(13±2)ng/ml、(34士3)U/ml和(32±3)U/ml,差异均有统计学意义(P<0.05).同时,3种抗原检测的敏感性和特异性各有特点,需要联合检测. 结论 联合检测良、恶性腹水中CEA、CA19-9和CA125水平对鉴别诊断有一定临床意义.%Objective To explore the clinical value of detecting CEA (cancer embryo antigen), CA19-9 (sugar 19-9 antigen), and CA125 (sugar antigen 125) to differentiate benign and malignant ascites. Methods CA19-9, CEA, and CA125 levels were determined by chemiluminescence detection in 120 patients with ascites. Results Chemiluminescence of patients with malignant ascites revealed a CEA level of (37± 16) ng/ml, a CA19-9 level of (236±78) U/ml, and a CA125 level of (602 + 211) U/ml while chemiluminescence of patients with benign ascites revealed a CEA level of (13± 2) ng/ml, a CA19-9 level of (34±3) U/ml and a CA125 level of (32 ± 3) U/ml. Differences were statistically significant (P<0. 05). Testing with 3 different antigens revealed a particular sensitivity and specificity, and combined testing was required. Conclusion Combined testing of CA19-9, CEA, and CA125 levels has some clinical significance in the differential diagnosis of benign and malignant ascites.

  13. Diatomáceas indicadoras de paleoambientes do Quaternário de Dois Irmãos, Recife, PE, Brasil Diatoms as indicators of paleoenvironments during the Quaternary at Dois Irmãos, Recife, Pernambuco State, Brazil

    Directory of Open Access Journals (Sweden)

    Giane Soares de Souza

    2007-09-01

    Full Text Available O trabalho apresenta o levantamento da diatomoflórula identificada em sedimentos do Quaternário da Lagoa das Diatomáceas (Dois Irmãos, Recife, baseado em um testemunho de sondagem com 4,5 m, tendo sido analisadas amostras com intervalos de 10 em 10 cm. Foram identificados 46 táxons, distribuídos em 19 gêneros, 40 espécies e seis variedades. A coluna estratigráfica esteve composta por gêneros epífitos (Actinella, Amphora, Cocconeis Eunotia, Fragilaria, Frustulia, Gomphonema e Rhopalodia, bentônicos (Navicula, Neidium, Nitzschia e Surirella e planctônicos (Aulacoseira, Cyclotella e Skeletonema. A maioria das espécies é oligoalóbia e litoral, destacando-se em termos de freqüência e abundância: Actinella brasiliensis, Anomoeoneis serians, Eunotia pectinalis, Frustulia rhomboides, sugerindo uma deposição de sedimentos em ambiente limnético. O predomínio de espécies epífitas em determinadas profundidades confirma a presença de macrófitas durante uma parte do período de deposição. Das espécies identificadas sete são consideradas de ambiente marinho: Cocconeis heteroidea, Cocconeis scutellum, Diploneis decipiens, Nitzschia scalaris, Nitzschia sigma, Skeletonema costatum e Surirella heideni as quais ocorreram de forma esporádica.A study of fossil diatoms from Lagoa das Diatomáceas (Dois Irmãos, Recife was carried out based on a 4.5-meter-long core sample. Samples were analyzed at 10 cm intervals. A total of 46 taxa were identified in 19 genera, 40 species and six varieties. The stratigraphic column was composed of epiphytic (Actinella, Amphora, Cocconeis Eunotia, Fragilaria, Frustulia, Gomphonema and Rhopalodia, benthic (Navicula, Neidium, Nitzschia, Surirella, and planktonic (Aulacoseira, Cyclotella and Skeletonema genera. Actinella brasiliensis, Anomoeoneis serians, Eunotia pectinalis and Frustulia rhomboides are oligohalobe, littoral species with high frequency and abundance, which suggests sediment deposition in a

  14. Evaluation of Roche Cobas E601 for Determining CEA%罗氏Cobas E601检测癌胚抗原的方法学性能评价

    Institute of Scientific and Technical Information of China (English)

    苏维; 王淑仙; 陈占良; 冯惠清; 段琳; 李逸阳

    2013-01-01

    目的:对罗氏Cobas E601全自动电化学发光免疫分析仪检测癌胚抗原(CEA)的分析性能进行验证。方法对CEA的精密度、准确度、测量线性范围、参考区间和交叉污染率进行验证实验。结果批内精密度高低两种浓度的(CV)分别为4.96%和4.38%,日间精密度高低两种浓度的CV分别为4.99%和4.81%;5份室间质控品的检测结果与靶值的偏倚在1.49%~3.57%;测量线性范围与厂家提供的范围相近;CEA的测量数值有96.3%在提供的参考区间内;交叉污染率为0.12%。结论罗氏Cobas E601检测CEA的方法学性能良好,检验结果准确可靠,能够满足临床检测的要求。%Objective To evaluate the effects of Roche Cobas E601 automatic electrochemiluminescence immunoassay analyzer for determining CEA. Methods To analyze E601’s measurement precision, accuracy, measurement range, reference interval and carryover rate of CEA, verification experiments were taken to measure. Results The high and low values of CV of inter-assay were 4.96%and 4.38%, and between-day CV were 4.99% and 4.81%; 5 quality-control serum’s relative bias were between 1.49%-3.57%; there was good linear relationship between measured values and expected values;there was 96.3%of the measurement data in the recommended reference interval;carryover rate range was 0.12%. Conclusion Roche Cobas E601 analyzer is stable, precise and accurate.

  15. Differential Diagnosis Value of Pleural Fluid ADA and CEA Detection for Tuberculous Pleuritis and Carcinomatous Pleuritis%胸水ADA、CEA检测在结核性与癌性胸膜炎鉴别诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    许能銮; 李瑞慧; 陈愉生; 林章树

    2007-01-01

    [目的]探讨胸水腺苷脱氨酶(ADA)和癌胚抗原(CEA)检测在结核性胸膜炎与癌性胸膜炎鉴别诊断中的价值.[方法]选择38例结核性胸膜炎和42例癌性胸膜炎住院患者,用速率法检测胸水ADA活性,电化学发光免疫法检测胸水CEA,评价二者诊断的真实性、预测值和似然比.[结果]结核性胸膜炎组ADA阳性率86.8%高于癌性胸膜炎组的2.4%(P<0.01);癌性胸膜炎组CEA阳性率71.4%高于结核性胸膜炎组的2.6%(P<0.01).ADA诊断结核性胸膜炎的敏感性为86.8%、特异性97.6%、正确诊断(约登)指数(Yoden's index)0.84、阳性预测值97.1%、阴性预测值89.1%、阳性似然比36.49、阴性似然比0.14;CEA诊断癌性胸膜炎的敏感性71.4%、特异性97.4%、约登指数0.84、阳性预测值96.8%、阴性预测值75.51%、阳性似然比27.16、阴性似然比为0.29.[结论]检测胸水ADA、CEA在结核性胸膜炎与癌性胸膜炎鉴别诊断中有重要的临床意义.

  16. Fatores associados à rosácea em amostras populacionais do Sul do Brasil: análise de estudos casos-controles Factors associated with rosacea in population samples of Southern Brazil: analysis of case-control studies

    Directory of Open Access Journals (Sweden)

    Renan Rangel Bonamigo

    2008-10-01

    Full Text Available FUNDAMENTOS: A rosácea é dermatose que apresenta uma série de variáveis associadas a seu surgimento. A maioria dos estudos é proveniente dos Estados Unidos da América e de países europeus, sendo escasso o conhecimento produzido e publicado acerca da doença no Hemisfério Sul, particularmente no Brasil. OBJETIVOS: Descrever os principais fatores clínicos e histopatológicos associados à rosácea em amostras populacionais do sul do Brasil. MÉTODOS: Dois estudos casos-controles realizados em seqüência, com análise univariada e bivariada, utilizando-se p BACKGROUND: Rosacea is a dermatosis that has many factors associated with its onset. Most studies on this condition come from the United States and European countries, with little information produced and published about the disease in the Southern hemisphere, particularly in Brazil. OBJECTIVES: To describe the main clinical and histopathological factors associated with rosacea in population samples from southern Brazil. METHODS: Two case-control studies performed sequentially, with univariate and bivariate analysis, using p<0.05 for statistical significance (Chi-square test and Mantel-Haenzel, for stratifications RESULTS: Rosacea is most frequent among women and in the age range of 40-50 years. Almost all cases have phototypes II and III. The inflammatory forms of rosacea are more often diagnosed than the vascular form and there is an association with serological positivity to Helicobacter pylori and with histopathological presence of Demodex folliculorum (p<0.05. Emotional and climatic changes, exposure to the sun and intake of alcoholic beverages were the main factors described as provoking or worsening the disease. CONCLUSIONS: We have obtained an overview of rosacea in a sample of the southern population of Brazil. While some data are similar to those already described internationally, other aspects, such as economic issues and the factors described as provoking or worsening the

  17. Effect of post-weld heat treatment on microstructure, hardness and low-temperature impact toughness of electron beam welds of NIFS-HEAT-2 and CEA-J57 heats of V–4Ti–4Cr alloy

    Directory of Open Access Journals (Sweden)

    V. Tsisar

    2016-12-01

    Full Text Available Bead-on-plate electron beam welding in high vacuum atmosphere was applied to the plates of NIFS-HEAT-2 and CEA-J57 heats of V–4Ti–4Cr alloy. Effect of post-weld heat treatment (PWHT in the temperature range 673–1273K on the hardness, impact toughness at 77K and microstructure of weld metal was investigated. After PWHT at 773K, hardness of weld metal slightly decreases from 180HV100 (as-welded state to ∼170HV100 while absorbed energy increases up to ∼10J showing ductile fracture mode. PWHT at 973K results in re-hardening of weld metal up to ∼180HV100 caused by re-precipitation of Ti–C,O,N precipitates and corresponding decreasing absorbed energy to ∼2J with brittle fracture mode. PWHT in-between 1073–1273K results in gradual recovery of hardness towards values comparable with those of base metal. Impact toughness (77 K of weld metal after PWHT at 1073K is not recovered nether to the value in as-welded state nor to that one of base metal.

  18. The changes and significance of serum CEA and GST-Pi before and after operation in patients with esophageal carcinoma%食管癌患者手术前后血清CEA、GST-Pi检测及意义

    Institute of Scientific and Technical Information of China (English)

    户秋生; 路平; 刘晶; 牛红蕊; 寇卫政

    2006-01-01

    目的 了解血清癌胚抗原(CEA)、谷胱苷肽转移酶Pi(glutathioneS-transferases,GSTs)在食管癌手术前后变化,探讨其作为食管癌标志物的价值.方法 放免法测定50例食管癌患者术前和术后血清中CEA、GST-Pi水平.结果 食管癌患者术前血清CEA和GST-Pi水平显著高于正常人(P<0.05),术后均明显降低,术前CEA值与临床分期、肿瘤体积呈正相关,GST-Pi与细胞分化程度呈正相关(P<0.05),联合表达阳性率高于单独表达.结论 血清CEA和GST-Pi与食管癌患者的病情、疗效密切相关,具有一定的临床应用价值.

  19. Preferência da broca-das-cucurbitáceas [Diaphania nitidalis Cramer, 1782 (Lepidoptera: Pyralidae] por cultivares de pepineiro em ambiente protegido Pickleworm [Diaphania nitidalis Cramer, 1782 (Lepidoptera: Pyralidae]preference for cucumber cultivars in greenhouse

    Directory of Open Access Journals (Sweden)

    Giovani Greigh de Brito

    2004-04-01

    Full Text Available A broca-das-cucurbitáceas (Diaphania nitidalis é uma praga de grande importância em diversas culturas, principalmente do pepineiro. Esta espécie pode apresentar preferência em relação a determinadas cultivares quanto à sua alimentação e até mesmo oviposição. Nesse sentido, o presente estudo objetivou avaliar a ocorrência desta praga em frutos de seis cultivares de pepineiro, em ambiente protegido. As cultivares Patton, Victoria, Premier, Vlaspik e Napoleon apresentaram, respectivamente, 50%, 43,75%, 37,50%, 34,37% e 25,87% dos frutos brocados. A cultivar Marinda apresentou resultado promissor, com apenas 10,37% dos frutos com presença de larvas de D. nitidalis.The pickleworm (Diaphania nitidalis is a major pest on different crops, particulary on cucumber. This species has shown a preference for determined cultivars to its feeding and oviposition habits. Thus, the aim of this study was to evaluate the occurence of D. nitidalis larvae in fruits of six cucumber cultivars in greenhouse. The cultivars Patton, Victoria, Premier, Vlaspik and Napoleon showed, respectively, 50%, 43.75%, 37.50%, 34.37% and 25.87% of bored fruits. Promising results were obtained with the cultivar Marinda, which showed only 10.37% of bored fruits.

  20. Diatomáceas perifíticas dos arroios Sampaio e Sampainho, Rio Grande do Sul, Brasil Periphitic diatoms from Sampaio and Sampainho streams, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Maria Angélica Oliveira

    2002-04-01

    Full Text Available Estudo taxonômico de diatomáceas perifíticas em substrato artificial (fio de poliamida foi realizado nos arroios Sampaio e Sampainho, localizados na Depressão Central do Estado do Rio Grande do Sul. A investigação baseou-se em amostragens mensais, realizadas no período de um ano (julho de 1994 a junho de 1995. Foram identificados, descritos e ilustrados vinte e um táxons infragenéricos, distribuídos em treze gêneros e onze famílias. Achnanthes rupestoides Hohn, Diadesmis brekkaensis (Petersen D. G. Mann, Navicula tenelloides Hustedt e Placoneis elginensis (Gregory E. J. Cox são registrados pela primeira vez em ambientes lóticos no Estado.Taxonomic study of periphitic diatoms on an artificial substrate (polyamide threads was undertaken in the Sampaio and Sampainho streams, that are located in the Depressão Central region of Rio Grande do Sul State. The investigation was based on monthly sampling taken from July 1994 to June 1995. Twenty one infrageneric taxa distributed in thirteen genera and eleven families were identified, described and illustrated. Achnanthes rupestoides Hohn, Diadesmis brekkaensis (Petersen D. G. Mann, Navicula tenelloides Hustedt and Placoneis elginensis (Gregory E. J. Cox are registered for the first time in lotic environments in this state.

  1. Enraizamento e crescimento de estacas herbáceas do cacaueiro (clones Cepec 42, tsh 516 e tsh 1188 em função da aplicação do ácido indolbutírico (AIB

    Directory of Open Access Journals (Sweden)

    Faria José Cláudio

    2003-01-01

    Full Text Available Estacas apicais herbáceas de ramos plagiotrópicos do cacaueiro (clones CEPEC 42, TSH 516 e TSH 1188 foram tratadas com 0 e 6.000 mg.kg-1 do ácido indolbutírico (AIB e estaqueadas em tubetes de 288 cm³ contendo como substrato uma mistura de Plantmax® e fibra de coco triturada (1:1, enriquecido com Osmocote® (19-06-20 e PG mix® (14-16-18. Os tubetes foram acondicionados em bandejas e estas foram mantidas em câmaras de nebulização. Na avaliação, realizada aos 78 dias após o estaqueamento, verificou-se que, independentemente da aplicação de AIB, as estacas dos clones avaliados apresentaram índices de enraizamento superiores a 87%, mas o tratamento das estacas com AIB aumentou os índices de sobrevivência e de estacas enraizadas de todos os clones, número de raízes (clones TSH 516 e TSH 1188, matéria seca de raízes (Clones CEPEC 42 e TSH 516 e matéria seca da parte aérea (Clones TSH 566 e TSH 1188.

  2. Análisis de la variabilidad genética de la colección colombiana de musáceas usando marcadores isoenzimáticos

    Directory of Open Access Journals (Sweden)

    Martha C Giraldo

    2011-04-01

    Full Text Available La Colección Colombiana de Musáceas (CCM es la única a nivel mundial que representa un alto valor por ser la que posee introducciones andinas de altura (> 1500 m.s.n.m.. La caracterización de este germoplasma puede generar valor agregado para su utilización en procesos de selección clonal y para el mejoramiento genético de la especie, mediante el uso de materiales diploides con características transmisibles de importancia. Por esta razón, 33 clones de la CCM conservadas in vitro, fueron evaluadas bioquímicamente mediante 10 enzimas, de las cuales cuatro fueron polimórficas: glutamato oxaloacetil transaminasa (GOT, ab-esterasa (ab-EST, peroxidasa (PRX y diaforasa (DIAP. La enzima GOT fue la más discriminante entre grupos genómicos particulares. PRX, DIAP y ab-EST permitieron evaluar la variabilidad al interior de cada grupo. El estudio facilita el entendimiento de la estructura genética de los genotipos de plátano y banano cultivados en Colombia.

  3. LHC: a cool 1.8 K is achieved for the first time : the temperature at which the accelerator is to operate in 2007

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    Photo 01 :Some of the team responsible for supervising the installation and commissioning of the cryogenic unit at Point 8. From left to right: Guillaume Vincent from the Air Liquide-Linde-Serco consortium in charge of operating CERN's cryogeic facilites, Gérard Ferlin, CERN project engineer, and Adrien Forgeas, from CEA Grenoble.

  4. Estudio experimiental de la infiltración leucocitaria de amígdalas palatinas durante la crisis aguda de la amigdalitis pultácea en niños: Implicaciones terapéuticas sobre la modulación de la inflamación

    OpenAIRE

    Alonso Rosa, D.; López González, M.A.; Mata Maderuelo, F.; Delgado Moreno, F.

    2002-01-01

    La infección de garganta es uno de los problemas más comunes durante la infancia. El Streptococcus pyogenes está presente en la mayoría de los casos de amigdalitis pultácea. El propósito de este estudio ha sido profundizar en el conocimiento de la respuesta inmune durante la crisis aguda y el período intercrisis de la amigdalitis pultácea. Veinte niños se diagnosticaron de amigdalitis aguda recurrente (más de 4 brotes por año durante más de 1 año) con indicación de amigdalectomía con o sin...

  5. CEA和CA19-9联合检测在直肠癌诊断及疗效评估中的应用价值%The value of CEA and CA19-9 in rectal cancer diagnosis and therapeutic effect evaluation

    Institute of Scientific and Technical Information of China (English)

    张静

    2016-01-01

    目的:研究癌胚抗原(carcino-embryonic antigen, CEA)和糖链抗原19-9(carbohydrate antigen 19-9, CA19-9)联合检测在直肠癌诊断及疗效评估中的应用价值。方法选择2011年5月至2015年5月我院60例直肠癌患者作为观察组,选择70例同期来我院健康体检者作为对照组。采用电化学发光法检测两组研究对象CEA和CA19-9水平,对检测结果进行统计学分析。结果观察组CEA和CA19-9检测结果均显著高于对照组,且差异均有统计学意义(P均<0.05);CA19-9单独检测诊断直肠癌的灵敏度、特异性及准确度均高于CEA;CEA和CA19-9联合检测诊断直肠癌的灵敏度、特异性及准确度均高于二者单独检测;随疾病疗效的恶化,CEA及CA19-9的检测水平均呈上升趋势,不同疗效患者CEA和CA19-9水平比较,差异均有统计学意义(P均<0.05),且组间两两比较,差异均有统计学意义(P均<0.05)。结论 CEA联合CA19-9能显著提高直肠癌检出率,对评估直肠癌放化疗疗效具有较高临床应用价值。%Objective To research the value of carcino-embryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in rectal cancer diagnosis and therapeutic effect evaluation. Methods 60 cases pa-tients with rectal cancer from May 2011 to May 2015 in our hospital were collected as observation group , and 70 cases healthy people at the same periods were collected as control group. The CEA and CA19-9 levels of all the subjects were detected by electrochemiluminescence method , and the results were analyzed statistically. Results The CEA and CA19-9 levels in observation group were all higher than that of control group , and the differences all had statistical significance (Pall<0.05). The sensitivity, specificity, and accuracy of CA19-9 were all higher than that of CEA in rectal cancer diagnosis. The sensitivity, specificity, and accuracy of CEA and CA19

  6. Decision no. 2011-DC-0224 of the French nuclear safety authority from May 5, 2011, ordering the French atomic energy and alternative energies commission (CEA) to proceed to a complementary safety evaluation of some of its basic nuclear facilities in the eyes of the Fukushima Daiichi nuclear power plant accident; Decision no. 2011-DC-0224 de l'Autorite de surete nucleaire du 5 mai 2011 prescrivant au Commissariat a l'Energie Atomique et aux energies alternatives (CEA) de proceder a une evaluation complementaire de la surete de certaines de ses installations nucleaires de base au regard de l'accident survenu a la centrale nucleaire de Fukushima Daiichi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    As a consequence of the accident of the Fukushima Daiichi nuclear power plant (Japan), the French Prime Minister entrusted the French nuclear safety authority (ASN) with the mission to carry out a safety analysis re-evaluation of the French nuclear facilities, and in particular the nuclear power plants. A decision has been addressed by the ASN to each nuclear operator with the specifications of this safety re-evaluation analysis and the list of facilities in concern. This document is the decision addressed to the French atomic energy commission (CEA). (J.S.)

  7. Clinical significance of detecting serum CA19-9,CEA,TGF-α and TGF-β1 in patients with pancreatic cancer%胰腺癌患者血清CA19-9、CEA、TGF-α和TGF-β1水平检测的临床意义

    Institute of Scientific and Technical Information of China (English)

    陆学安

    2014-01-01

    目的:探讨胰腺癌患者血清CA19-9、CEA、TGF-α和TGF-β1水平的变化及临床意义。方法:对30例胰腺癌患者应用放射免疫分析法进行血清 CA19-9、CEA、TGF-α和 TGF-β1水平检测,并与35例正常人比较。结果:胰腺癌患者血清 CA19-9、CEA、TGF-α和 TGF-β1水平均非常显著高于正常人组(P<0.01)。且血清 CA19-9水平与CEA、TGF-α、TGF-β1水平呈正相关(r=0.4925、0.6015、0.5984,P<0.01)。结论:对胰腺癌患者进行血清CA19-9、CEA、TGF-α和TGF-β1水平的检测并分析其变化情况,对疾病的诊断和治疗均有一定的临床价值。%Objective:To investigate the changes of serum CA19-9 CEA,TGF-α and TGF-β 1 in patients with pancreatic cancer and its clinical significanc.Methods:30 patients with pancreatic cancer were detected the level of serum CA19-9,CEA, TGF-α and TGF-β1 by radioimmunoassay,and they were compared with the levels of 35 normal people.Results:The levels of serum CA19-9,CEA, TGF-α and TGF-β1 in patient with pancreatic cancer were significantly higher than that of the normal group(P<0.01).And there were positively relationship between the level of serum CA19-9 and the levels of CEA,TGF-α, TGF-β1(r=0.4925,0.6015,0.5984,P<0.01).Conclusion:If we detected the levels of serum CA19-9,CEA,TGF-α and TGF-β1 in patients with pancreatic cancer and analyzed the changes of those levels,it can bring some certainly clinical values on the diagnosis and treatment of this diseases.

  8. Detection CEA,CA125,CA153 in breast cancer patients and its correlation with quality of life%乳腺癌患者CEA、CA125、CA153检测及其与生活质量的相关性分析

    Institute of Scientific and Technical Information of China (English)

    潘中华

    2013-01-01

    Objective To study the level of CEA,CA125,CA153 in breast cancer patients and its correlation with quality of life. Methods the breast cancer patients were selected as observation group,benign breast disease patients as benign control group, and healthy people as healthy control group,the peripheral blood levels of CEA,CA125, CA153 were detected and quality of life were observed. Results The CEA,CA125,CA153 levels and physical function,psychological function,social function,cognitive function,overall quality of life scores of observation group were significantly higher than benign control group and healthy control group;physical function,psychological function,social function,cognitive function,overall quality of life score were negatively correlated with CEA,CA125,CA153 levels. Conclusion The clinical value of positive CEA,CA125,CA153 examination in the diagnosis of breast cancer,which is closely related with the quality of life.%  目的研究乳腺癌患者血清中CEA、CA125、CA153的水平及其与生活质量的相关性。方法选择乳腺癌患者作为观察组、乳腺良性疾病患者作为良性对照组、健康体检者作为健康对照组,检测外周血中CEA、CA125、CA153的含量并观察生活质量相关指标。结果观察组患者CEA、CA125、CA153水平以及躯体功能、心理功能、社会功能、认知功能、总体生活质量评分明显高于良性对照组和健康对照组;躯体功能、心理功能、社会功能、认知功能、总体生活质量评分与CEA、CA125、CA153水平呈负相关。结论CEA、CA125、CA153检查对乳腺癌的诊断具有积极的临床价值,且与生活质量密切相关。

  9. Organic matter quality in a soil cultivated with perennial herbaceous legumes Qualidade da matéria orgânica de um solo cultivado com leguminosas herbáceas perenes

    Directory of Open Access Journals (Sweden)

    Luciano Pasqualoto Canellas

    2004-02-01

    Full Text Available Using herbaceous legumes in agricultural systems yields great quantities of plant residues, allowing changes in soil organic matter quality and content over the years. This study was conducted on an Ultisol, at Seropédica, RJ, Brazil, to evaluate the effects of different perennial herbaceous legumes on soil organic matter quality. A factorial scheme with three replications was used to evaluate the species: forage groundnut cv. BR-14951 (Arachis pintoi, tropical kudzu (Pueraria phaseoloides, and siratro (Macroptilium atropurpureum. After the first cut, each plot was divided into two subplots; plants were cut and left on the soil surface or cut and removed. Soil samples of a closed area covered by spontaneous vegetation (mainly C3 plants or by Panicum maximum were also analysed. Samples were collected from two layers (0-5 and 5-10 cm, processed for the fractionation of organic matter and the evaluation of structural characteristics of humic acids (HA. Evaluated legumes did not change total organic carbon contents, but promoted HA accumulation in the superficial soil layer. Humic acids may be used as indicators of the management effects on soil organic fractions, because there was significant incorporation of carbon and nitrogen derived from the legume residues, even for the short experimentation time (28 months. Residue management did not modify quantitative aspects of the distribution of the humified organic matter, but promoted, however, a higher condensation degree of humic acids evaluated by the elementary composition, IR and fluorescence spectroscopy.O uso de leguminosas herbáceas em sistemas agrícolas permite o aporte de quantidades expressivas de fitomassa, possibilitando alterações no teor e na qualidade da matéria orgânica do solo ao longo dos anos. Este trabalho avalia a qualidade da matéria orgânica de um Argissolo Vermelho Amarelo localizado em Seropédica, RJ, e cultivado com diferentes espécies de leguminosas herbáceas

  10. Side Effects of Fungicides Used in Cucurbitaceous Crop on Trichogrammaatopovirilia Oatman & Platner (Hymenoptera: Trichogramatidae Efectos Secundarios sobre Trichogramma atopovirilia Oatman & Platner (Hymenoptera: Trichogramatidae de Fungicidas usados en Cucurbitáceas

    Directory of Open Access Journals (Sweden)

    Dirceu Pratissoli

    2010-06-01

    producción de cucurbitáceas en Trichogramma atopovirilia Oatman & Platner sobre huevos de D. hyalinata. Se evaluaron los fungicidas azoxystrobina (0.08 g ingrediente activo [ia] L-1, clorotalonil (2.00 g ia L-1, mancozeb (1.60 g ia L-1, tebuconazole (0.25 g ia L-1 and tiofanato-metil (0.49 g ia L-1. Tarjetas con 30 huevos de D. hyalinata previamente sumergidos en los fungicidas y en agua destilada (control fueron ofrecidas a 20 hembras de T. atopovirilia con hasta 24 h de emergencia individualizadas en tubos de vidrio. Se evaluó parasitismo, reducción de parasitismo, emergencia, proporción sexual en la población y el número de individuos emergidos por huevo. Los fungicidas clorotalonil, tiofanato-metil y tebuconazol redujeron el parasitismo de T. atopovirilia en 43,37; 27,64 y 18,51%, respectivamente. Sin embargo, el parasitismo con azoxistrobina (79,21% fue mayor que el control (67,37% (P ≤ 0,05. Clorotalonil, tiofanato-metilo y el tebuconazol redujo la aparición de 73,77, 75,62 y 79,35% (P ≤ 0,05, respectivamente. Azoxistrobina y tiofanato-metil reduciran la proporción de sexos de 0,77 y 0,76 (P ≤ 0,05, respectivamente. Ninguno de los fungicidas redujo el número de individuos por cada huevo. Los fungicidas azoxistrobina y mancozeb fueron selectivos para T. atopovirilia en la mayoría de los parámetros estudiados, por lo tanto, deberían tener prioridad en el manejo de enfermedades de cucurbitáceas para permitir el uso eficiente de los enemigos naturales de D. hyalinata.

  11. Estudo da Faciologia Orgânica em Rochas Geradoras Marinhas Cretáceas do Grupo Villeta, Bacia do Valle Superior del Magdalena,Colômbia: Implicações Paleoambientais.

    Directory of Open Access Journals (Sweden)

    Juliana Andrade Iemini

    2007-07-01

    Full Text Available As rochas pelíticas do Cretáceo superior são asgeradoras da maior parte das reservas de petróleo naColômbia. A Bacia do Valle Superior Del Magdalena(VSM, possui afloramentos de boa qualidade e comníveis de evolução térmica, que variam desde oimaturo até o fim da “janela” de geração de óleo,tornando esta região como uma das mais propíciaspara o estudo dos processos de geração e migraçãoprimária do petróleo no Cretáceo superior. O objetivoprincipal consistiu no estudo de fácies orgânicaatravés da caracterização geoquímica e análisepalinofaciológica das rochas geradoras de petróleocretáceas do VSM numa seção aflorante (QuebradaBambuca, objetivando o entendimento do controleexercido pela evolução paleoambiental sobre opotencial gerador e as variações composicionaisda matéria orgânica a partir da integração dosdados geoquímicos e palinofaciológicos. Paratanto, foram utilizadas análises organogeoquímicas(Carbono Orgânico Total - COT e Pirólise Rock-Eval, cedidas pelo Instituto Colombiano doPetróleo ICP - ECOPETROL e palinofaciológicasem amostras das Formações Tetuan Bambuca e LaLuna, Grupo Villeta, Bacia do Valle Superior delMagdalena. As rochas dessa formação apresentamum elevado conteúdo orgânico, com valores deCOT de até 23%. As lâminas organopalinológicasforam analisadas através de técnicas de palinofácies(microscopia em luz branca transmitida e luz azul/ultravioleta incidente-fluorescência realizando acontagem dos componentes orgânicos particuladosdos grupos do querogênio (fitoclasto, palinomorfoe matéria orgânica amorfa e da determinação doÍndice de Coloração de Esporos (ICE. A analisemicroscópica revelou um predomínio de matériaorgânica amorfa. Os palinomorfos são representadospor dinoflagelados e esporomorfos, sendo osdinoflagelados os mais representativos. A matériaorgânica amorfa apresenta fluorescência amarelaa laranja. O material lenhoso representa a

  12. Contribuição das folhas cotiledonares para o crescimento e estabelecimento de plântulas de cucurbitáceas Cotyledonary leaf contribution for growth and establishment of cucurbit seedlings

    Directory of Open Access Journals (Sweden)

    Dilson Antônio Bisognin

    2004-06-01

    Full Text Available As cucurbitáceas apresentam germinação epigeal, cujos cotilédones têm a dupla função de fornecer substâncias de reserva e fotoassimilados para o crescimento e o estabelecimento da plântula. O objetivo deste trabalho foi quantificar o nível de dependência de plântulas de abóbora híbrida (Cucurbita maxima x C. moschata, melancia (Citrullus lanatus, pepino (Cucumis sativus e porongo (Lagenaria siceraria em relação às folhas cotiledonares para o crescimento e estabelecimento inicial. Foi efetuada a remoção de um ou dois cotilédones aos 3; 6; 9 e 12 dias após a emergência (DAE, comparando-se o crescimento das plântulas com o de plântulas controle (sem remoção. O crescimento inicial foi avaliado a cada três dias, da emergência até 21 DAE, determinando-se a taxa de expansão das folhas cotiledonares, o período de tempo até a equivalência entre área foliar e cotiledonar e a produção de matéria seca. A abóbora apresentou a maior taxa de expansão das folhas cotiledonares, o menor período até a emissão e expansão das folhas verdadeiras e a maior produção de matéria seca. As plântulas de abóbora e pepino apresentaram a maior dependência em relação às folhas cotiledonares. Os resultados obtidos mostram que danos às folhas cotiledonares, dependendo da espécie, da intensidade e da idade da plântula, podem afetar drasticamente o crescimento inicial e o estabelecimento das plântulas, com reflexos evidentes no rendimento de frutos em cucurbitáceas.Cucurbit species have epigeal cotyledons adapted for both storage and photoassimilation functions. Seedling dependence on cotyledonary leaves for initial growth and establishment was quantified for hybrid squash (Cucurbita maxima x C. moschata, watermelon (Citrullus lanatus, cucumber (Cucumis sativus, and bottlegourd (Lagenaria siceraria. One or both cotyledons were excised at 3; 6; 9; and 12 days after emergence (DAE and initial growth was compared to control

  13. Análisis de la variabilidad genética de la colección colombiana de musáceas usando marcadores isoenzimáticos

    Directory of Open Access Journals (Sweden)

    Giraldo Martha C.

    2011-06-01

    Full Text Available La Colección Colombiana de Musãceas (CCM es la ünica a nivel mundial %ue representa un alto valor por ser la %ue posee introducciones andinas de altura (& 1( m.s.n.m.. La caracterización de este germoplasma puede generar valor agregado para su utilización en procesos de selección clonal - para el mejoramiento genético de la especie, mediante el uso de materiales diploides con características transmisibles de importancia. Por esta razón, 33 clones de la CCM conservadas in vitro, fueron evaluadas bio%uimicamente mediante 1 enzimas, de las cuales cuatro 4ueron polimór7cas: glutamato o=aloacetil transaminasa (GOT, a13-esterasa (a13HIJL, pero=idasa (PMQ - dia4orasa (DVWP. La enzima GYL 4ue la mãs discriminante entre grupos genómicos particulares. PMQ, DVWP - a13HIJL permitieron evaluar la variabilidad al interior de cada grupo. Il estudio 4acilita el entendimiento de la estructura genética de los genotipos de plátano y banano cultivados en Colombia. .

  14. Hallazgo de espeleotemas silíceas en rocas graníticas del batolito de Achala, Sierras Pampeanas de Córdoba Occurrence of silica speothems in granitic rocks of the Achala batholith, Sierras Pampeanas of Córdoba

    Directory of Open Access Journals (Sweden)

    Marcela A. Cioccale

    2008-09-01

    Full Text Available Se presentan los primeros resultados en relación con el hallazgo de espeleotemas silíceas en rocas graníticas del batolito de Achala (Córdoba. Estas espeleotemas constituyen formas de acumulación en un ambiente dominado por procesos erosivos; alcanzando un desarrollo de unos de pocos milímetros hasta dos centímetros de espesor. Se localizan en grietas abiertas y paredes de tafonis. Presentan morfologías variadas que incluyen estalactitas y espeleotemas tipo flowstone. Están compuestas por sílice amorfa (ópalo A, yeso y fragmentos detríticos de cuarzo, feldespatos y micas. El modelado geoquímico, mediante el programa PHREEQC, permite simular la formación de estas espeleotemas a partir de procesos de evaporación del agua que circula a través de la roca fracturada.We are reporting on the occurrence of silica speleothems in granitic outcrops of the Achala batholith (Córdoba. Speleothems are accumulation forms which occur in environments dominated by erosive processes. They usually reach a thickness that varies between a few milimeters and 2 cm, and grow in fractures or in taffonis walls. Its morphology is varied and includes stalactites and flowstonetype speleothems. They are mainly composed of amorphous silica (opal-A and mineral detritus (quartz, feldspar, and mica. PHREEQC modelling allows simulating the genesis of speleothems, progressively increasing the evaporation of meteoric water that flows through fractured zones.

  15. CEA、CA125、CYFRA21-1和NSE在肺癌中的诊断价值%Diagnostic value of CEA, CA125, CYFRA21-1, and NSE in lung cancer

    Institute of Scientific and Technical Information of China (English)

    余才华; 马志红; 李鸿伟; 沈琦斌; 费淑祎; 刘亚萍

    2013-01-01

    目的 探讨综合运用Logistic回归和受试者工作特征曲线(ROC曲线)分析四项肿瘤标志物对肺癌的诊断价值.方法 采用放射免疫法检测1 12例原发性肺癌和74例肺良性疾病患者血清中癌胚抗原(CEA)、糖类抗原-125(CA125)、细胞角蛋白片段19(CYFRA21-1)和神经元特异性烯醇化酶(NSE)的表达水平.通过Logistic回归建立回归模型,用ROC曲线分析4项肿瘤标志物在肺癌诊断中的意义.结果 肺癌患者血清中CEA、CA125、CYFRA21-1和NSE的表达水平[4.53(2.22-11.53) ng/ml、28.97(11.39-62.10) U/ml、4.05(2.29-8.18) ng/ml、14.11(11.35-24.12)ng/ml]明显高于肺良性疾病患者[2.08(1.45-2.52) ng/ml、12.90(9.80-19.44)U/ml、1.53(1.21-2.17) ng/ml、11.38(9.07-12.80) ng/ml],差异有统计学意义(均P<0.01).通过Logistic回归建立回归方程Y=1/[1 +EXP(4.902-0.394X1-0.627X2-0.165X3)],经ROC曲线分析,新变量Y的ROC曲线下面积(AUC)为0.915 ±0.020,敏感度79.46%、特异度93.24%、准确度84.95%.结论 运用Logistic回归和ROC曲线综合分析可提高肺癌的诊断.%Objective To explore the diagnostic value of four tumor markers analyzed with Logistic regression and receiver operator characteristic (ROC) curve in patients with lung cancer.Methods The serum levels of carcinoembryonic antigen (CEA) 、carbohydrate antigen 125 (CA125),cytokeratin 19 fragment (CYFRA21-1) and neuron specific enolase (NSE) were determined by radioimmunoassay in 112 patients with lung cancer and 74 patients with benign pulmonary disease.Four tumor markers were analyzed by Logistic regression and ROC curve.Results The serum levels of CEA,CA125,CYFRA21-1 and NSE in lung cancer patients were [4.53(2.22-11.53)ng/ml,28.97 (11.39-62.10) U/ml,4.05(2.29-8.18)ng/ml,14.11 (11.35-24.12) ng/ml],respectively,which were significantly higher than those in health adults[2.08 (1.45-2.52) ng/ml,12.90 (9.80-19.44) U/ml,1.53 (1.21-2.17) ng/ml,11.38 (9.07-12.80) ng/ml] (all P < 0.01).According to

  16. 联合检测血清CEA、CYFRA21-1、NSE在肺癌诊断、分期、分型中的意义%Clinical Values of Combined Serum CEA,CYFRA21-1 and NSE Detection in Diagnosis,Staging and Predicting Pathologic Typing of Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    徐恩赐; 王利利; 周菊英

    2012-01-01

    目的 探讨血清癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)在肺癌诊断、临床分期以及病理分型中的作用.方法 采用化学发光法、放射免疫分析法和酶联免疫吸附法分别检测114 例肺癌患者和89例肺部良性疾病患者血清CEA、CYFRA21-1、NSE水平.结果 肺癌组血清CEA、CYFRA21-1、NSE含量明显高于肺良性疾病组(P<0.05);CEA、CYFRA21-1及NSE诊断肺癌的ROC曲线下面积分别是0.60、0.85、0.82;联合检测对肺癌诊断的灵敏度明显高于任何单一检测(P<0.05);Ⅰ+Ⅱ期肺癌组血清CEA含量明显高于肺良性疾病组(P<0.05);CEA 在腺癌组含量明显高于鳞癌组(P<0.05);NSE在小细胞肺癌组含量明显高于鳞癌组和腺癌组(P<0.05);血清CEA在Ⅰ、Ⅱ、Ⅲ期非小细胞肺癌组含量明显低于Ⅳ期(P<0.05);CYFRA21-1在Ⅰ、Ⅱ期非小细胞肺癌组含量明显低于Ⅲ、Ⅳ期(P<0.05).结论 CEA对肺癌的早期诊断有一定意义;血清CEA对腺癌的灵敏度最佳,NSE对小细胞肺癌的灵敏度最佳;早期肺癌血清CEA、CYFRA21-1水平明显低于晚期肺癌;三种肿瘤标志物联合检测可明显提高肺癌诊断的敏感性,对肺癌的临床诊断、病理分型、临床分期具有重要的临床意义.%Objective To evaluate the value of combined serum carcinoembryonic antigen(CEA),cytokeratin fragment 19(CYFRA21-1) and neuron-specific enolase(NSE) detection for diagnosis,staging and predicting of pathologic types in patients with pulmonary carcinoma.Methods The levels of CEA,CYFRA21-1 and NSE were measured in 114 patients with pulmonary carcinoma and 89 patients with pulmonary benign lesion,using chemoluminescence,RIA and ELISA methods respectively.Results The concentrations of CEA,CYFRA21-1 and NSE in the cancer patients group were obviously higher than those in benign lung diseases group(P < 0.05). In single index the ROC area of serum CEA,CYFRA21-1 and NSE was 0

  17. Clinical Significance of the detection of CA153,CA125,CEA and SF Serum Test in Breast Cancer%肿瘤标志物CA153、CA125、CEA和SF联合检测对乳腺癌的诊断价值

    Institute of Scientific and Technical Information of China (English)

    刘征宇; 温蔚

    2009-01-01

    目的 探讨肿瘤标志物CA153、CA125、CEA和SF联合检测在乳腺癌中的临床应用价值.方法 利用化学发光免疫方法检测60例乳腺良性疾病(乳腺良性疾病组)和40例健康体检者(对照组)以及60例乳腺癌患(乳腺癌组)治疗前后血清CA15-3、CA125、CEA和SF的水平,并进行分析.结果 乳腺癌组治疗前CA153、CA125、CEA、SF水平[(52.8±21.3)u/ml、(44.2±20.1)ng/ml、(8.9±5.2)ng/ml、(350.5±113.8)ng/ml]均显著高于乳腺良性疾病组[(17.3±8.8)u/ml、(15.6±8.5)u/ml、(2.0±0.8)u/ml、(1220.7±46.91)ng/ml](t=2.671,t=2.684,t=2.898,t=2.844,P均<0.01);乳腺癌组患者血清CA15-3、CA125、CEA和SF治疗前的水平(同上)明显高于治疗后[(25.5±3.7)u/ml、(15.0±8.4)u/ml、(4.6±3.3)ng/ml、(98.5±58.6)ng/ml](t=2.210,t=2.165,t=2.224,t=2.234,P均<0.05);乳腺良性疾病组与正常对照组差异无统计学意义(t=1.644,t=1.757,t=1.67,t=1.741,P均>0.05);乳腺癌组CA153+CA125+CEA+SF四项联检阳性率53.3%低于CA153(56.7%)、CA125(58.3%)、CEA(63.3%)、SF(68.3%)(χ~2=2.52,χ~2=2.652,P>0.05;χ~2=3.85,χ~2=3.90,χ~2=3.98,P<0.05).结论 血清CA15-3、CA125、CEA、SF联合检测可提高乳腺癌的阳性检出率,对乳腺癌的早期诊断、疗效监测以及预后判断均有重要意义.%Objective To study the clinical significance of sernm CA153,CA125 and CEA test in breast cancer.Methods The levels of CA153,CA125,carcinoembryonic antigen(CEA)and ferritin were measured in 60 patients with breast cancer(breast cancer group),36 patients with benign breast diseases(benign breast diseases group)and 40 healthy people(control group)by chemiluminometry.The four indices were compared and analyzed for their complementary diagnostic value to breast cancer.Results The levels of CA153,CA125,CEA,SF[(52.8±21.3)u/ml,(44.2±20.1)ng/ml,(8.9±5.2)ng/ml,(350.5±113.8)ng/ml]in breast cancer group were significantly higher than that of benign breast disease group[(17.3±8.8)u/ml,(15.6±8.5)u

  18. Update on ignition studies at Cea

    Energy Technology Data Exchange (ETDEWEB)

    Holstein, P.A.; Casanova, M.; Casner, A.; Cherfils, C.; Dattolo, E.; Disdier, L.; Galmiche, D.; Giorla, J.; Houry, M.; Jadaud, J.P.; Laffite, S.; Liberatore, S.; Loiseau, P.; Lours, L.; Masse, L.; Monteil, M.C.; Morice, O.; Naudy, M.; Philippe, F.; Poggi, F.; Renaud, F.; Riazuelo, G.; Saillard, Y.; Seytor, P.; Vandenboomgaerde, M.; Wagon, F. [CEA Bruyeres-le-Chatel, 91 (France)

    2007-08-15

    This article sums up the theoretical and experimental studies about ignition. Three experiments are salient this year on the Omega laser in collaboration with DOE laboratories. First, 3 cones of beams have allowed to mimic the LMJ (laser MegaJoule) configuration and to get symmetry measurements. Secondly, we have measured perturbations due to hydro-instability in CHGe planar samples with face-on and side-on radiographs. And thirdly, we have improved our nuclear diagnostics, particularly the neutron image system tested on direct drive implosions. As far as LMJ target design is concerned, we have defined a preliminary domain corresponding to the possible operation at 2{omega}. At 3 {omega} we have studied the low mode instability effects on the DT deformation (due to the laser or to the target) and on the yield. The stability is clearly improved with graded doped CH for our nominal capsule L1215. (authors)

  19. Differential diagnostic value of pleural effusion combined with serum ADA and CEA for tubercu lous and malignant pleural exudates%胸水和血清ADA、CEA联合检测对结核性和恶性胸腔积液的诊断价值

    Institute of Scientific and Technical Information of China (English)

    陈辉; 庞华春

    2009-01-01

    Objective To study the diagnostic value of pleural effusion combined with serum adenosine deaminase(ADA),carcinoemhryonic antigen(CEA)in testing tuberculous and malignant pleural exudates.Methods Diagnostic kit for carcinoe mbryonic antigen(CEA)and ADA measured by ELISA and Enzyme continuotrs monitoring method was examined among 91 patients with pleural exudates.Results The ADA activity of tuberculous and malignant exudates were respectively(42.32±17.56)U/L and(10.29 4-6.34)U/L(P<0.01).If the critical value of ADA was larger than 40U/L in tuberculous diagnosis,its sensitivity Was 82.5%and the specificity was92.2%as the critical value of ADA mole than 40U/L.its sensitivity was 92.5%and the specificity Wag 90.2%as the critical value of PADA/SADA more than 1.The CEA activity of tuberculous and malignant exudates were respectively(8.314±3.62)ug/L and (24.7±1 3.6)ug/L(PCEA was larger than 20ug/L in malignant pleural exudates,its sensitivity was 58.8%and specificity was 95.0%.If the critical value of PCEA/SCEA was larger than 1 in malignant pleural exudates,its sensitivity was 86.3%and the specificity was 92.5%.Conelusion The test of ADA and CEA of pleural exudates is of great diagnostic value in patients with tubeleulous and malignant pleural effusion.%目的 探讨胸水和血清腺苷脱氨酶(ADA)、癌胚抗原(CEA)联合检测对结核性和恶性胸腔积液的诊断价值.方法 采用酶连续监测法和酶联免疫(ELISA)双抗体夹心法对91例胸腔积液进行胸水和血清ADA和CEA检测分析.结果 ADA活性在结核性和恶性胸腔积液中分别为(42.32±17.56)U/L和(10.29±6.34)U/L(P<0.01).以PADA>40U/L做为诊断结核的临界值,其灵敏性为82.5%,特异性为92.2%;以PADA/SADA>1为临界值,其灵敏性为92.5%,特异性为90.2%.CEA活性在结核性和恶性胸腔积液中分别为(8.31±3.62) μg/L和(24.7±13.6) μg/L(P<0.01).以PCEA>20μg/L做为诊断恶性胸腔积液

  20. Logistic回归和ROC曲线综合评价CEA、NSE和CYFRA21-1对肺癌的诊断价值%Evaluation of the diagnostic values of serum CEA, NSE and CYFRA21-1 in lung cancer

    Institute of Scientific and Technical Information of China (English)

    林卫虹; 廖伟娇; 郑君德; 钟丽红

    2011-01-01

    Objective To explore the application of serum carcinoembryonic antigen (CEA), neuron-specificenolase (NSE) and cytokeratin 19 fragment (CYFRA21-1) for the diagnosis of lung cancer.Methods The levels of serum CEA ,NSE and CYFRA21-1 in patients with lung cancer,patients with benign lungs diseases were determined by electrochemiluminescence (ECLIA).Logistic regression and ROC curve were applied to analyze the data and evaluate the diagnostic values.Results The concentrations of serum CEA, NSE and CYFRA21-1 in patients with lung cancer were significantly higher than the other two groups (P<0.01).The serum level of CEA was highest in patients with adenocarcinoma.NSE was the most sensitive tumor marker (81.6%)for small cell lung cancer.When the specificity was 90% ,CYFRA21-1 had the highest sensitivity in lung cancer.According to the regression model, Y=l/[1 +EXP(5.830-0.249X1-0.198X2-0.643X3)], the sensitivity, specificity and accuracy of the new variable Y was 80.9%, 91.3% and 84.6%, respectively.Conclusion Serum CEA, NSE and CYFRA21-1 in lung cancer has a high diagnostic value.Tbe use of Logistic regression and ROC curve can improve the diagnosis of lung cancer.%目的 应用Logistic回归和ROC曲线探讨血清癌胚抗原(carcinoembryonic antigen,CEA)、神经元特异性烯醇化酶(neuron-specificenolase,NSE)和细胞角蛋白19片段(cytokeratin 19 fragment,CYFRA21-1)在肺癌诊断中的应用.方法 采用电化学发光免疫分析仪(E170)检测不同病理类型肺癌组、肺良性疾病组以及健康人血清CEA、NSE和CYFRA21-1的水平,通过Logistic回归建立回归模型,用ROC曲线分析三指标对肺癌诊断的意义.结果 肺癌组CEA、NSE和CYFRA21-1的水平显著高于肺良性疾病和健康人组(P<0.01).腺癌组血清CEA水平最高,NSE在小细胞肺癌中灵敏度最高(81.6%),取特异性90%时,CYFRA21-1对肺癌的诊断灵敏度最高(59.5%).建立回归模型Y=1/[1+EXP(5.830-0.249X1-0.198X2-0.643X3)],新变量Y

  1. The differential diagnosis value of CEA, CYFRA21-1, NSE and LDH in the blood and pleural fluid of patients with benign or malignant pleural effusion%CEA、CYFRA21-1、NSE、LDH在良恶性胸腔积液中的鉴别诊断价值

    Institute of Scientific and Technical Information of China (English)

    巩强进; 吕志; 吴丹; 胡先纬; 胡杰贵

    2012-01-01

    Objective To determine the differential diagnosis value of the tumor markers Carcinoembryonic Antigen( CEA ), Cy-tokeratin 19 fragment (CYFRA21-1 ),Neuron Specific Enolase( NSE ) and LDH in the blood and pleural fluid of patients with benign or malignant pleural effusion. Methods We prospectively evaluated the value of CEA, CYFRA21-1, NSE and LDH in the blood and pleural fluid of 108 patients with pleural effusion. Of which, 55 were diagnosed with malignant pleural effusion, and 53 were diagnosed with benign effusion. The optimum cut-off points resulting from the best sensitivity-specificity balance in the ROC curves were constructed. Results There were significant differences between malignant and benign cases for CEA and CYFRA21-1, in blood,and for CYFRA21-1、NSE、 CEA、LDH in pleural fluid . In the pleural fluid, the sensitivity and specificity of CEA, CYFRA21-1, NSE and LDH was 90. 9、63. 6、 72.7、36.4% and 98. K83、67. 9、88.1% .respectively. In the blood, the sensitivity and specificity was 89. K87. 3、32. K25. 5% and 92. 5、79. 2、90. 6、92. 5% for CEA, CYFRA21-1, NSE and LDH, respectively. Conclusions The results suggest that these markers might be useful in the differentiation between malignant and benign pleural effusion.%目的 探讨血清及胸腔积液中癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经特异性烯醇化酶(NSE)、乳酸脱氢酶(LDH)在良恶性胸腔积液鉴别诊断价值.方法 分析我院55例肺癌患者和53例良性胸腔积液患者的血清及胸腔积液中CEA、CYFRA21-1、NSE、LDH检测水平,并根据受试者工作特性(ROC)曲线建立合理的临床判断临界值及检测的敏感性和特异性.结果 恶性患者胸水CYFRA21-1、NSE、CEA、LDH的水平高于良性患者(P<0.05).胸水CEA、CYFRA21-1、NSE、LDH的敏感性和特异性分别为90.9、63.6、72.7、36.4%和98.1、83、67.9、88.7%.血清CEA、CYFRA21-1、NSE、LDH的敏感性和特异性分别为89.1、87.3 、32.1

  2. Application value discussion of CEA, CA19-9, CA242, CA72-4 in early diagnosis of rectal cancer%CEA、CA19-9、CA242、CA72-4在直肠癌早期诊断的应用价值探讨

    Institute of Scientific and Technical Information of China (English)

    周永玲

    2015-01-01

    目的:探讨联合检测癌胚抗原(CEA)、糖类抗原19-9(Carbohydrate antigen 19-9,CA19-9)、糖类抗原242(carbohydrate antigen 242,CA242)、糖类抗原72-4(Carbohydrate antigen 72-4,CA72-4)对直肠癌早期诊断价值。方法采用化学发光法联合检测直肠癌组、直肠良性病变组和健康对照组血清中 CEA、CA19-9、CA242、CA72-4浓度,并进行统计学分析。结果直肠癌组患者血清中 CEA、CA19-9、CA242、CA72-4的含量均明显高于直肠良性病变组及健康对照组,差异有统计学意义(P<0.05),直肠良性病变组和健康对照组比较差异无统计学意义,直肠癌组患者血清四项标志物联合检测的阳性率:72.587%(45/62)高于 CEA 单项检测的阳性率61.29%(38/62)。结论联合检测血清中 CEA、CA19-9、CA242、CA72-4含量可有显著的互补性效提高直肠癌的诊断诊断率,是早期筛查直肠癌一中简单,有效的方法。%Objective To investigate early diagnosis value of CEA, CA19-9, CA242, CA72-4 for rectal cancer. Methods applying chemiluminescence combined with testing serum concentrations of CEA,CA19-9,CA242,CA72-4 of rectal cancer, rectal benign lesion, health control group, and carry on statistical analyis. Result CEA, CA19-9, CA242 and CA72-4 contents in serum of rectal cancer groups were significantly higher than rectal benign lesion and healthy control group, and difference shows statistical significance(P<0.05). Comparison between rectal benign lesion and healthy control group shows no statistical significance. And positive rate of combination test for four markers in serum of rectal cancer group was 72.587% (45/62), which was higher than 61.29% (38/62) of CEA test only. Conclusion combination test for CEA, CA19-9, CA242 and CA72-4 contents can significantly improve diagnostic rate of rectal cancer, which is a simple and effective method for early screening of rectal cancer.

  3. Caracterización física, morfológica y evaluación de las curvas de empastamiento de musáceas (Musa spp.

    Directory of Open Access Journals (Sweden)

    Javier Darío Hoyos-Leyva

    2012-07-01

    Full Text Available Se caracterizaron veinte variedades de musáceas de diferente composición genética: AB, BB, AAA, AAB, ABB, AAAA y AAAB, del Banco de Germoplasma existente en la hacienda Las Vegas, de Fedeplátano, Chinchiná (1360 m.s.n.m., 4° 58' N y 75° 20' O, Colombia. La caracterización incluyó propiedades físicas como peso, diámetro, longitud, materia seca y porcentaje de cáscara del fruto y propiedades funcionales como harinas y almidones. El análisis de componentes principales (ACP mostró que las variedades de plátano se diferencian por su mayor tamaño (peso, longitud y diámetro. M. B. Tani, ICAFHIA 110, Saba, y los plátanos del subgrupo Bluggoe tuvieron altos porcentajes de cáscara. Entre los demás clones no se observaron diferencian entre sí. Los plátanos de cocción del subgrupo Plantain presentaron el mayor contenido de materia seca. Bocadillo Chileno e híbridos postre (exceptuando FHIA-1, presentaron mayor contenido de fracción comestible frente a las demás variedades. La temperatura de inicio de gelatinización de las harinas en el RVA varió entre 66.58 °C para la variedad Bocadillo Chileno y 75.21 °C para Mbindi. La viscosidad máxima varió entre 441.57 y 1837.17 cP para las variedades Tafetán Rojo y Dwarf Cavendish, respectivamente. La facilidad de cocción varió entre 2.76 min en Bocadillo Chileno y 7.55 min en Gros Michel Guayabo. La temperatura de inicio de gelatinización de los almidones varió entre 65.58°C para Gros Michel Guayabo y 74.41°C en Tafetán Rojo. La variedad Yangambi Km3 presentó la viscosidad máxima a 483.24 cP e Indio a 1958.44cP. La variedad Mbindi presentó la mayor facilidad de cocción (1.91 min mientras que FHIA-1 presentó el mayor tiempo (9.49 min.

  4. Composição da comunidade de diatomáceas periféricas do rio Jaú, Amazonas, Brasil Composition of the periphytic diatom community of the Jaú river, Amazonas, Brazil

    Directory of Open Access Journals (Sweden)

    José Gerley Díaz-Castro

    2003-12-01

    Full Text Available Foi realizado um estudo da flora perifítica de diatomáceas (Bacillariophyceae existente no Rio Jaú, tributário do Rio Negro, Amazônia (2º57'S e 61º49'W. As coletas foram realizadas manualmente nas cheias de 1995, 1996 e 1997, e as lâminas permanentes encontram-se depositadas no Herbário FLOR, Universidade Federal de Santa Catarina. Foram identificados 60 táxons específicos e infra-específicos, distribuidos em 16 gêneros e 13 famílias. Eunotiaceae foi a família melhor representada, com 43,3% do total dos táxons inventariados, seguida de Pinnulariaceae com 21,6% e Surirellaceae com 11,6%. O gênero Eunotia destacou-se dentre os demais com 20 táxons. Eunotia e Pinnularia foram os gêneros mais abundantes da flora diatomológica e os que apresentaram maior variação morfológica. Para cada táxon identificado foi feita uma revisão de literatura que incluem diversos aspectos ecológicos.The periphytic diatom flora of the Jaú River, a tributary of the Negro River, in Amazonia (2º 57' S; 61º49' W was studied. Algae were collected manually during the high water periods of 1995, 1996 and 1997 and permanent slides prepared from this material were deposited in the FLOR Herbarium of the Federal University of Santa Catarina. Sixty specific and infra-specific taxa were identified, distributed among 16 genuses and 13 families. Eunotiaceae was the best represented family, with 43.3% of all taxa inventoried, followed by Pinnulariaceae with 21.6% and Surirellaceae with 11.6%. Accounting for 20 taxa. Eunotia and Pinnularia were the dominant genuses and showed the broadest morphological variation. Eunotia was the best. The relevant literature for each taxon was reveiwed and discussed.

  5. Identificação e caracterização de espécies de Colletotrichum associadas à antracnose de anonáceas no estado de Alagoas

    Directory of Open Access Journals (Sweden)

    Sandra Hiromi Kamei

    2014-01-01

    Full Text Available No Brasil, Colletotrichum gloeosporioides é a única espécie associada à antracnose de anonáceas. Contudo, apenas características morfológicas têm sido utilizadas na identificação. Assim, o objetivo do trabalho foi identificar e caracterizar espécies de Colletotrichum que causam a antracnose nas culturas da pinha e da graviola no Estado de Alagoas. Cinquenta e um isolados, obtidos de folhas de pinheira e gravioleira com sintomas típicos da doença, foram coletados em Maceió, Palmeira dos Índios e União dos Palmares. Os isolados foram inoculados em folhas destacadas de ambas as culturas e caracterizados morfologicamente através da morfometria de conídios e apressórios, e molecularmente por meio do sequenciamento da região ITS. Verificou-se que todos os isolados foram patogênicos a ambas as espécies. Na caracterização morfológica, os isolados foram agrupados em três grupos: M1, M2 e M3. O grupo M1 foi formado por 32 isolados com características relacionadas a C. gloeosporioides. No grupo M2, constituído de 15 isolados, predominaram características de C. boninense, enquanto, no grupo M3, composto por quatro isolados, as características foram típicas de C. fragariae. A análise filogenética, da mesma forma, também resultou em três grupos (F1, F2 e F3, os quais, de modo geral, estiveram em concordância com os dados da morfologia. O grupo filogenético F1 concentrou os isolados do grupo morfológico M1 e sequências de referências de C. gloeosporioides e C. fragariae. O grupo F2, que agrupou as sequências de C. boninense, concentrou os isolados do grupo morfológico M2. Finalmente, o grupo F3 incluiu sequências de C. magna e outros quatro isolados desse estudo. Assim, foi possível comprovar que quatro espécies de Colletotrichum são responsáveis pela antracnose em pinheira e gravioleira em Alagoas: C. gloeosporioides, C. boninense, C. fragariae e C. magna.

  6. Diatomaceous earth effects on weevils with different susceptibility standard to phosphine Efeito da terra de diatomácea sobre carunchos com diferentes padrões de susceptibilidade à fosfina

    Directory of Open Access Journals (Sweden)

    Patrícia M. da Conceição

    2012-01-01

    Full Text Available The aim of this study was to evaluate the insecticide activity of diatomaceous earth (DE, at different temperatures, on two populations of Tribolium castaneum and Rhyzopertha dominica previously diagnosed as resistant and susceptible to phosphine. The efficiency of DE in the control of the insects was evaluated at temperatures of 20, 25, 30, 35 and 40 ± 2 ºC. The experiments were accomplished in Petri dishes containing 35 g of whole-wheat grain treated with DE in the dose of 1.0 kg t-1. The control was constituted by untreated wheat grain. Each Petri dish was infested with 30 adult insects. Insect mortality was registered seven days after the beginning of the bioassays. The experiment was conducted in a completely randomized design with three replications. The populations of T. castaneum and R. dominica, respectively, resistant and susceptible to phosphine have similar susceptibility patterns. The mortality of two populations of T. castaneum increased with increasing temperature. For R. dominica, the mortality did not change with the temperature.O objetivo deste trabalho foi avaliar a atividade inseticida da terra de diatomácea (TD, em diferentes temperaturas, em relação a duas populações de Tribolium castaneum e Rhyzopertha dominica previamente diagnosticadas como resistentes e susceptíveis à fosfina. A eficiência da TD foi avaliada nas temperaturas de 20, 25, 30, 35 e 40 ± 2 ºC e os experimentos foram realizados em placas de Petri contendo 35 g de grãos inteiros de trigo, tratados com TD na dose de 1,0 kg t-1. O controle foi constituído de grãos de trigo não tratados; ressalta-se que cada placa de Petri foi infestada com 30 insetos adultos, cuja mortalidade foi contabilizada sete dias após o início dos bioensaios. O delineamento experimental utilizado foi o inteiramente casualizado, com três repetições. As populações de T. castaneum e R. dominica, respectivamente, resistentes e susceptíveis à fosfina apresentaram padr

  7. 联合检测粪便癌胚抗原和钙卫蛋白诊断大肠癌的临床价值%Clinical value of combined detection of calprotectin and CEA in colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    郭汉斌; 曹建彪; 王志红; 李浩然

    2009-01-01

    目的 联合检测粪便中癌胚抗原(CEA)及钙卫蛋白,探讨其诊断大肠癌的临床应用价值.方法 收集北京军区总医院消化内镜中心接受肠镜检查病人的新鲜粪便标本共177例,其中大肠癌48例,结直肠息肉51例,功能性肠病78例.采用ELISA法半定量检测粪便中钙卫蛋白及癌胚抗原浓度,比较其在不同组中的差异;应用ROC曲线确定最佳临界值,并对两个检测指标进行综合评价.结果大肠癌组粪便钙卫蛋白及CEA含量的中位数分别为470(0.9~1 380.61)μg/g,19.42(0.46~109.78)μg/g,高于其余组,差异有统计学意义(P0.05);ROC曲线分析提示:以12.09μg/g为临界点,CEA诊断大肠癌的灵敏度为73%,特异度为56%;以104.2μg/g为临界点,钙卫蛋白诊断大肠恶性肿瘤的灵敏度为90.1%,特异度为54.2%;钙卫蛋白联合CEA诊断大肠癌的灵敏度为97.3%,特异度为30.35%.结论 粪便钙卫蛋白及CEA检测大肠癌有较高的敏感性,且不受肿瘤部位的影响,可以作为门诊筛查大肠癌的标志物.

  8. VARIABILIDAD GENÉTICA DE AISLAMIENTOS COLOMBIANOS DE Phytophthora infestans (Mont de Bary EN SOLANÁCEAS CULTIVADAS EN COLOMBIA GENETIC VARIABILITY OF ISOLATES OF Phytophthora infestans (Mont. de Bary IN SOLANACEOUS CROPS FROM COLOMBIA

    Directory of Open Access Journals (Sweden)

    Natalia Raigosa Gómez

    2009-06-01

    Full Text Available Se estudio el nivel de variabilidad genética de una población de 35 aislamientos de Phytophthora infestans obtenidos en diferentes hospedantes y regiones geográficas de Colombia, mediante las técnicas de haplotipos mitocondriales y RAPD. Los resultados encontrados sugieren la existencia en el país de los haplotipos mitocondriales Ia en los aislamientos que afectan tomate de árbol (Solanum betaceum y IIa en cultivos de papa; dichos haplotipos están asociados a los linajes genéticos EC-3 y EC-1, respectivamente. Sin embargo, tres aislamientos obtenidos en tomate de mesa (S. lycopersicum, pimentón (Capsicum sp. y pepino de agua (S. muricatum requieren de un análisis posterior, debido a la falta de correlación entre los perfiles de restricción generados con los cuatro pares de cebadores utilizados en esta prueba y los haplotipos mitocondriales mencionados en la literatura. De otra parte, mediante cuatro cebadores RAPD, fue posible encontrar variabilidad al interior de los dos linajes genéticos, siendo interesante el hecho que los aislamientos obtenidos en tomate de árbol (EC-3 fueron divididos en dos grupos, relacionados con una distancia genética de 0,17. Estos hallazgos indican que es importante contemplar las fuentes de variación asexual en el análisis de la estructura poblacional de este oomycete y por tanto en el diseño de las estrategias de control de las enfermedades que causa P. infestans en cultivos de solanáceas de importancia económica.The level of genetic variability of 35 isolates of Phytophthora infestans obtained from different hosts and geographical regions of Colombia was studied through mitochondrial haplotypes and RAPD techniques. Results suggested the existence of mitochondrial haplotypes Ia affecting tree tomato (Solanum betaceum and IIa in potato, which are associated with genetic lineages EC-3 and EC-1, respectively. However, three isolates obtained from tomato (S. lycopersicum, capsicum (Capsicum sp. and

  9. Análise da estrutura da comunidade de diatomáceas (Bacillariophyceae em duas estações do sistema Guaíba, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Eduardo A Lobo

    1987-12-01

    Full Text Available Através da análise da composição específica e da diversidade da comunidade de diatomáceas, em duas estações do sistema Guaíba (RS, Brasil, nos meses de setembro e novembro de 1975, foi encontrada uma diferença significativa na estrutura dessa comunidade. Essa diferença deve-se, provavelmente, à presença exclusiva de Achnanthes inflata (Kütz. Grun. var. elata (Leud. - Fort.Hust., A. lanceolata (Bréb.Grun. var. lanceolata, Cocconeis placentula Ehr., Cyclotella meneghiniana Kütz., Cymbella minuta Hilse ex Rabh., Aulacosira distans (Ehr. Sim., Navicula mutica Kütz., Surirella robusta Ehr. var. splendida (Ehr. Van Heurck, Synedra ulna (Nitz.Ehr., espécies abundantes, que refletem características ambientais distintas, pelo fato de apresentarem uma diferenciação em suas tolerâncias ecológicas. Foram identificados um total de 114 táxons, 57 a níveis específicos e infra-específicos, dentre os quais 14 constituem-se em primeira referência para o Guaíba e quatro são citações novas para o Estado.Through the analysis of specific composition and diversity of diatom community, in two sampling areas of the Guaíba system (RS, Brasil in September and October 1975, a meaningful difference in the structure of that community was found. Such difference is probably due to exclusive presence of Achnanthes inflata (Kütz.Grun. var. elata (Leud. - Fort.Hust., A. lanceolata(Bréb.Grun. var. lanceolata, Cocconeis placentula Ehr., Cyclotella meneghiniana Kütz., Cymbella minuta Hilse ex Rabh., and of Aulacosira distans(Ehr. Sim., Navicula mutica Kütz., Surirella robusta Ehr. var. splendida (Ehr.Van Heurck, Synedra ulna(Nitz.Ehr., abundant species which reflect different environmental characteristics because of their different ecological tolerances. A total of 114 taxa have been identified; 57 of them to specific and infraespecific levels, 14 of which mentioned for the first time in the Guaíba system and 4 for the first time in the state.

  10. CEA启动子启动双自杀基因CD/TK重组AdEasy XL腺病毒构建%The construct of replication deficient AdEasy XL adenovirus containing CEA promoter, CD and TK gene

    Institute of Scientific and Technical Information of China (English)

    王天宝; 汪建平; 董文广; 钟女奇; 周军

    2005-01-01

    目的构建含有CEA启动子(CEA promoter,Cp)启动的双自杀基因CD与TK的复制缺陷型腺病毒.方法设计带有限制性内切酶酶切序列的PCR引物.在2μl T4 DNA ligase作用下,Cp插入pAdTrack(pAT)的MCS,形成pAT.Cp;CD插入pAT.Cp的MCS,形成pAT.Cp.C;TK插入pAT.Cp.C的MCS,形成pAT.Cp.C.T.5 μg pAT.Cp.C.T经4 μl Pme Ⅰ线化后,转化BJ5183-AD-1,1μl PacⅠ酶切鉴定.重组AdEasy质粒转化XL10-Gold细胞,大量扩增提取纯化,转染5 × 105 AD-293细胞,荧光显微镜观察,制备带有Cp.C.T重组腺病毒(recombinant adenovirus with Cp.C.T,RA-Cp.C.T),测定病毒滴度.结果pAT.Cp,pAT.Cp.C,pAT.Cp.C.T双酶切以及PCR均见长约500 bp的Cp,1 300 bp的CD,1 100 bp的TK.对照质粒DNA转化BJ5183-AD-1效率为7.36×106 cfu/μg.线化pAT.Cp.C.T转化BJ5183-AD-1,形成重组AdEasy质粒DNA,Pac Ⅰ酶切见典型长约3.0或4.5kb与30.0kbDNA片断.重组质粒转染AD-293出现绿色荧光.RA-Cp.C.T滴度为5.67×107 pfu/ml.结论RA-Cp.C.T构建正确;AdEasy XL腺病毒载体系统转导Cp.C.T具有高效性,易于观察转染效果.

  11. Efeito de extratos aquosos de meliáceas sobre Bemisia tabaci biótipo B em tomateiro Effect of aqueous extracts of meliaceous plants on Bemisia tabaci B biotype on tomato plants

    Directory of Open Access Journals (Sweden)

    ANTONIO PANCRÁCIO DE SOUZA

    2000-01-01

    Full Text Available Comparou-se a bioatividade de extratos aquosos a 3% (p/v de três meliáceas, Melia azedarach L. (frutos verdes, Trichilia pallida Swartz (ramos e Azadirachta indica A. Juss (sementes, em relação à mosca branca Bemisia tabaci (Gennadius biótipo B, criada em tomateiro. No primeiro experimento os extratos foram aplicados sobre ovos e sobre ninfas com três dias de idade, avaliando-se a mortalidade e a duração das fases de ovo e de ninfa. No segundo experimento os extratos foram aplicados apenas sobre as ninfas, avaliando-se a mortalidade nessa fase e a longevidade e fecundidade dos adultos. Em relação à fase de ovo, o extrato de T. pallida foi o que provocou maior mortalidade, seguindo-se os de A. indica e M. azedarach. A maior mortalidade ninfal foi constatada com o extrato de A. indica, seguindo-se os de T. pallida e M. azedarach. Nenhum dos extratos afetou a duração das fases de ovo e de ninfa, assim como a longevidade e fecundidade.The objective of this research was to compare the effect of aqueous extracts of fresh fruits of Melia azedarach L., twigs of Trichilia pallida Swartz and seeds of zadirachta indica A. Juss, on eggs and nymphs of silverleaf whitefly Bemisia tabaci (Gennadius B biotype reared on tomato plants. The extracts were tested at a concentration of 3%. In the first experiment, the extracts were applied on eggs and 3-day-old nymphs. Records were taken on mortality, duration of egg and nymphal stages. In the second experiment the extracts were applied on 3-day-old nymphs and records were taken on nymphal mortality, adult longevity and fecundity. The extracts of T. pallida were the most effective on eggs, followed by A. indica and M. azedarach. The extracts of A. indica were the most effective on nymphs followed by T. pallida and M. azedarach. In both experiments, the duration of egg and nymph stages, longevity and fecundity were not affected by the extracts.

  12. An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: III. Expressions of EMA, CEA, CA19-9, CDX-2, p53, Ki-67 antigen, TTF-1, vimentin, and p63 in normal mucosa and in 42 cases.

    Science.gov (United States)

    Terada, Tadashi

    2013-01-01

    There have no comprehensive immunohistochemical studies of primary signet ring cell carcinoma (SRCC) in the stomach and colorectum. The author examined the expression of nine common antigens (EMA, CEA, CA19-9, CDX-2, p53, Ki-67 antigen, TTF-1, vimentin, and p63) in the non-tumorous normal epithelium of the stomach and colorectum and in 42 cases of primary SRCC of the stomach (30 cases) and colorectum (12 cases). The normal epithelium of the stomach and colon consistently (100%) expressed EMA, CEA, CA19-9, CDX-2, and Ki-67 (labeling EMA was 57% (17/30), CEA 100% (30/30), CA19-9 100% (30/30), CDX-2 43% (13/30), p53 83% (25/30), Ki-67 100% (30/30) (labeling index= 36 ± 23 %), TTF-1 0% (0/30), vimentin 0% (0/30), and p63 0% (0/30). In primary colorectal SRCC, the expression percentage of EMA was 25% (3/12), CEA 100% (12/12), CA19-9 100% (12/12), CDX-2 93% (28/30), p53 75% (9/12), Ki-67 100% (30/30) (labeling index= 47% ± 26 %), TTF-1 0% (0/12), vimentin 0% (0/12), and p63 0% (0/12). A comparative statistical analysis showed significant difference in EMA (gastric SRCC 57% vs colorectal SRCC 25%) and CDX-2 (43% vs 93%). There were no significant differences in the other seven antigens' expression between primary gastric SRCC and primary colorectal SRCC. These findings provide much knowledge of primary SRCC of the stomach and colorectum. The data indicated primary gastric SRCC frequently express EMA but not CDX-2 whereas primary colorectal SRCC frequently express CDX-2 but not EMA. These findings also suggest that EMA and CDX-2 are down-regulated during the gastric SRCC carcinogenesis. This down regulations may be associated with the malignant transformation of gastric SRCC. The data of colorectal SRCC suggest EMA is markedly down-regulated and also suggest that this EMA down-regulation may be associated with the carcinogenesis of colorectal SRCC. The expression pattern of EMA and CDX-2 may be useful in differential diagnosis between primary gastric SRCC and primary

  13. 血清IGF-1及CEA、CYFRA21-1、NSE联合检测在肺癌诊治中的价值%Combination of IGF-1 with CEA, CYFRA21-1, NSE for the diagnosis and prediction of treatment response in lung cancer

    Institute of Scientific and Technical Information of China (English)

    许峰; 吴翼伟; 章斌

    2011-01-01

    目的 研究血清胰岛素样生长因子(IGF-1)及CEA、细胞角质素片断抗原(CYFRA21-1)、神经元特异性烯醇化酶(NSE)联合检测在肺癌诊治中的临床价值,以筛选理想的血清肿瘤标志物组合.方法 应用放射免疫分析法检测30名健康人、91例肺癌患者和15例肺部良性疾病患者血清IGF-1,同时应用电化学发光免疫分析法测定同一批研究对象的血清CEA、CYFRA21-1、NSE水平,采用Kruskal-Wallis单因素方差分析Mann-Whitney秩和检验进行统计学比较.用ROC曲线对各项指标的诊断效能进行分析和评价,曲线下面积(AUC)采用Wilcoxon检验分析.结果 肺癌患者的血清IGF-1水平及3种血清肿瘤标志物水平均明显高于健康人组和肺部良性疾病组,差异有统计学意义(IGF-1:χ2=26.95,P<0.001;CEA:χ2=49.11,P<0.001;CYFRA21-1:χ2=40.63,P<0.001;NSE:χ2=14.76,P<0.001),治疗后肺癌患者的IGF-1及CYFRA21-1水平比未治疗患者的IGF-1水平低,差异有统计学意义(IGF-1:χ2=5.99,P=0.014;CYFRA21-1:χ2=4.99,P=0.025).IGF-1、CEA、CYFRA21-1和NSE在特异性为95.6%(43/45)时,灵敏度分别为75.6%(34/45)、53.3%(24/45)、66.7%(30/45)和42.2%(19/45),以IGF-1最高;各指标的ROC AUC分别为0.880、0.836、0.891和0.697,以IGF-1与CYFRA21-1较高;联合检测以IGF-1+CYFRA21-1与IGF-1+CEA+CYFRA21-1较好,灵敏度分别达到95.6%(43/45)和97.8%(44/45),AUC分别为0.969和0.984.结论 血清中IGF-1、CEA、CYFRA21-1和NSE对肺癌的诊断均有一定的临床价值.IGF-1可判断疗效并进行随访.IGF-1与CEA、CYFRA21-1、NSE联合检测可显著提高肺癌诊断的灵敏度和效能,IGF-1+CYFRA21-1与IGF-1+CEA+CYFRA21-1是诊断肺癌较为理想的组合.%Objective To evaluate four tumor markers of insulin-like growth factor 1((IGF-1), CEA, cytokeratin fragment antigen 21-1 (CYFRA21-1), neuron-specific enolase (NSE) for the diagnosis and prediction of treatment response in human lung cancer. Methods Serum samples were taken from

  14. Expression and clinical significance of Twist,VEGF,CEA,CYFRA21-1,NSE in malignant pleural effusion of patients with lung cancer%Twist蛋白、VEGF、CEA、CYFRA21-1、NSE在肺癌患者恶性胸水中的表达和应用

    Institute of Scientific and Technical Information of China (English)

    韩娟; 颜浩; 张凌

    2016-01-01

    目的:探讨肺癌患者恶性胸水中Twist蛋白、血管内皮生长因子(VEGF)、癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经原特异性烯醇化酶(NSE)的表达及其临床意义。方法采集52例肺癌患者恶性胸腔积液标本,其中腺癌24例,鳞癌16例,小细胞肺癌12例,良性胸腔积液患者45例作为对照。应用酶联免疫吸附试验法和化学发光法检测各指标水平。结果肺癌组恶性胸水中 Twist 蛋白、VEGF、CEA、CYFRA21-1、NSE 的表达均高于良性肺病组(t值分别为8.67、9.11、3.94、5.37、3.10,P值均0.05),CEA 水平在腺癌中最高,CYFRA21-1水平在鳞癌中最高,NSE水平在小细胞肺癌中最高。Twist 蛋白、VEGF、CEA、CYFRA21-1、NSE 在肺癌恶性胸水中的敏感度分别为78.8%、84.6%、61.5%、46.2%、42.3%,特异度分别为86.7%、88.9%、91.1%、86.7%、77.8%。CEA、CYFRA21-1、NSE在不同肺癌恶性胸水中敏感度不同,联合检测可提高敏感度。结论胸水中 Twist 蛋白、VEGF、CEA、CYFRA21-1、NSE 检测有利于良、恶性胸水的鉴别, Twist蛋白、VEGF水平与肿瘤病理类型无关,CEA、CYFRA21-1、NSE 水平与肿瘤病理类型相关,联合检测可提高诊断的敏感度。%Objective To investigate the expression and clinical significance of Twist protein, vascular endothelial growth factor (VEGF),carcino-embryonic antigen (CEA),cytokerantin-1 9-fragment (CYFRA2 1-1),neuron-specific enolase (NSE) in lung cancer patients with malignant pleural effusion. Methods The specimens of 52 cases of lung cancer with malignant pleural effusion were gathered, including 24 cases of adenocarcinoma,16 case of squamous cell carcinoma,and 12 cases of small cell lung cancer.45 patients with benign lung diseases were selected as controls.The expressions of markers were detected by enzyme-linked immunosorbent assay and chemical luminescence method.Results The expressions of Twist protein,VEGF,CEA,CYFRA2 1-1 ,NSE in malignant pleural

  15. Enraizamento de estacas lenhosas e herbáceas de cultivares de caquizeiro com diferentes concentrações de ácido indolbutírico Rooting of hardwood and herbaceous cuttings of japanese persimmon tree cultivars treated with different concentration of indolbutyric acid

    Directory of Open Access Journals (Sweden)

    Débora Costa Bastos

    2005-04-01

    Full Text Available Desenvolveu-se este trabalho com o objetivo de estudar a capacidade de enraizamento de estacas lenhosas e herbáceas de cultivares de caquizeiro tratadas com AIB. Estacas lenhosas e herbáceas foram coletadas de ramos de caquizeiro das cultivares Pomelo, Rama Forte, Taubaté, Giombo e Fuyu e submetidas à aplicação de AIB (0; 3.000 e 6.000 mg.L-1 por vinte segundos. Em seguida, as estacas foram colocadas em canteiro contendo uma mistura de terra + esterco de curral (3:1 v/v como substrato (estacas lenhosas e em bandejas de poliestireno expandido, contendo vermiculita média, em câmara de nebulização intermitente (estacas herbáceas. Como conclusão, observou-se que as cultivares de caquizeiro apresentam diferenças quanto ao potencial de formação de raízes e brotações; estacas herbáceas apresentam maior tendência na propagação via estaquia em comparação às estacas lenhosas.This work was carried out with the objective to study the capacity of rooting of hardwood and herbaceous cuttings of Japanese persimmon tree cultivars treated with IBA. Hardwood and herbaceous cuttings were collected from branches of Japanese persimmon tree and submitted to treatments in function of cultivars (Pomelo, Rama Forte, Taubaté, Giombo and Fuyu and of application of IBA (0, 3,000 and 6,000 mg.L-1 for twenty seconds. Later the cuttings were placed in stonemason containing a soil mixture + corral manure (3:1 v/v as substrate (hardwood cuttings and in polyethylene trays containing vermiculite as substrate, in intermittent mist chamber (herbaceous cuttings. As conclusion is observed that the cultivars of Japanese persimmon tree present differences in relationship to potential of roots and shoots formation; herbaceous cuttings present higher tendency in the propagation through cutting in comparison with the hardwood cuttings.

  16. Mortalidade do ácaro predador Neoseiulus californicus (Acari: Phytoseiidae em testes de toxicidade residual de inseticidas e acaricidas usuais em pomáceas Mortality of predatory mite Neoseiulus californicus (Acari: Phytoseiidae in residual toxicity persistence tests

    Directory of Open Access Journals (Sweden)

    Marcelo Gustavo Ruiz

    2008-12-01

    Full Text Available Os ácaros fitoseídeos, especialmente Neoseiulus californicus (McGregor, são importantes agentes de controle biológico de ácaros tetraniquídeos-praga nas culturas de pomáceas no "Alto Valle del Río Negro y Neuquén", Argentina. Neste trabalho, avaliou-se a mortalidade de N. californicus quando exposto a resíduos dos inseticidas azimphos-methyl, carbaryl e cyfluthrin, e dos acaricidas cyhexatin e propargite. Os produtos foram aplicados às concentrações recomendadas em plantas de pereira. Um, três, seis e dez dias após a aplicação (DAA, folhas tratadas foram retiradas das plantas para a preparação de unidades experimentais. Cinco adultos de N. californicus, provenientes de criação-estoque, foram transferidos para cada unidade, onde pólen de taboa foi fornecido como alimento. As unidades foram mantidas a 25 ± 2 ºC, 60 ± 10% de umidade relativa e fotoperíodo de 14 h. A mortalidade do ácaro foi avaliada 24 h após o confinamento. As médias de mortalidade foram comparadas pelo teste de Dunnett, a 5% de probabilidade. A progressão do declínio do efeito dos produtos testados foi submetida à análise de regressão. Nas duas primeiras datas de avaliação, todos os produtos apresentaram valores de mortalidade significativamente diferentes da testemunha tratada com água. Seis dias após a aplicação, propargite, cyhexatin e cyfluthrin apresentaram mortalidade de aproximadamente 30%, enquanto a mortalidade nos tratamentos azimphos-methyl e carbaryl apresentou níveis estatisticamente similares aos da testemunha. Dez dias após a aplicação, a mortalidade em todos os tratamentos não diferiu significativamente da testemunha. O efeito de todos os produtos apresentou declínio progressivo ao longo do período de observação, sendo significativa a 1% de probabilidade a regressão linear negativa para os valores obtidos. Os maiores efeitos negativos sobre a sobrevivência de N. californicus corresponderam aos acaricidas testados

  17. Education and training in the field of nuclear instrumentation and measurement: CEA/INSTN (National Institute for Nuclear Sciences and Technologies) strategy to improve and develop new pedagogical tools and methods

    Energy Technology Data Exchange (ETDEWEB)

    Vitart, Xavier; Foulon, Francois; Bodineau, Jean Christophe; Lescop, Bernard; Massiot, Philippe [CEA/INSTN Centre des Saclay 91191 Gif sur Yvette (France)

    2015-07-01

    Part of the French Alternative Energies and Atomic Energy Commission (CEA), the National Institute for Nuclear Science and Technology (INSTN) is a higher education institution whose mission is to provide students and professionals a high level of scientific and technological qualification in all disciplines related to nuclear energy applications. In this frame, INSTN carries out education and training (E and T) programs in nuclear instrumentation and radioprotection. Its strategy has always been to complete theoretical courses by training courses and laboratory works carried out on an extensive range of training tools that includes a large panel of nuclear instrumentation as well as software applications. Since its creation in 1956, the INSTN has conducted both education and vocational programs on ionizing radiation detection. An extensive range of techniques have commonly been used during practical works with students and employees of companies who need to get the knowledge and specialization in this field. Today, the INSTN is mainly equipped with usual detectors and electronics in large numbers in order to be able to accommodate up to 48 trainees at the same time in two classrooms, with only two trainees for one workstation in order to optimize their learning. In the field of the neutron detection systems, the INSTN has strongly developed its offer taking advantage of the use of research reactors, such as ISIS reactor (700 kW) at Saclay. The implementation of neutron detection systems specific to the courses offers a unique way of observing and analysing the signal coming from neutron detectors, as well as learning how to set the parameters of the detection system in real conditions. Providing the trainees with an extensive overview of each part of the neutron monitoring instrumentation apply to a nuclear reactor, hands-on measurements on the ISIS reactor play a major role in ensuring a practical and comprehensive understanding of the neutron detection system and

  18. Iota-carrageenans from Solieria filiformis (Rhodophyta and their effects in the inflammation and coagulation=Iota-carragenanas da rodofícea Solieria filiformis e seus efeitos na inflamação e coagulação

    Directory of Open Access Journals (Sweden)

    Norma Maria Barros Benevides

    2012-04-01

    Full Text Available Biochemical analyses are important tools for discovering new bioactive compounds for medical clinic. This study aimed at isolating iota-carrageenans (ι-CARs from Solieria filiformis (Rhodophyta by enzymatic extraction (EE, refined hot-water extraction (RHWE and hot-water extraction (HWE, and test (EE, s.c. their anti-inflammatory effects in the peritonitis model using the Lambda-carrageenan (700 µg cavity-1, i.p. as an inflammatory stimuli in rats. The activated partial thromboplastin time (APTT was also evaluated in ι-CARs fractions, obtained by ion-exchange chromatography (DEAE-cellulose, using rabbit plasma and compared to heparin (193 IU mg-1. The results showed that the ι-CARs (EE (3 or 9 mg kg-1 containing 89.92% total sugars, 29.02% sulfate and absence of contaminant proteins inhibited (p 0.05. Similar chromatography profiles were obtained among the methods; however, with fractions revealing different pattern on charge density by electrophoresis. Fractions had no virtually effects on APTT (1.16, 1.73 and 1.59 IU mg-1 for EE, RHWE and HWE, respectively. Further investigations to better understanding the actions of S. filiformis ι-CARs (EE in the inflammatory response are suggested.Análises bioquímicas são ferramentas importantes para a descoberta de novos compostos bioativos para clínica médica. Neste estudo, iota-carragenanas (ι-CARs da rodofícea Solieria filiformis foram isoladas (extração enzimática (EE, extração aquosa a quente refinada (EAQR ou extração aquosa a quente (EAQ e testadas (EE; s.c. no modelo de peritonite, usando-se a Lambda-carragenana (700 µg cavidade-1; i.p. como um estímulo flogístico, para averiguar seus efeitos anti-inflamatórios em ratos. O tempo de tromboplastina parcial ativada (TTPA também foi avaliado em frações de ι-CARs, obtidas por cromatografia de troca iônica (DEAE-celulose, usando plasma de coelho e comparadas à heparina (193 UI mg-1. Verificaram-se que ι-CARs (EE (3 ou 9 mg

  19. Rhizobia amylase production using various starchy substances as carbon substrates Produção de amilase por rizóbios, usando várias substâncias amiláceas como substratos de carbono

    Directory of Open Access Journals (Sweden)

    Arlem Nascimento de Oliveira

    2007-06-01

    Full Text Available Six isolates of indigenous rhizobia of Central Amazonia were screened for the production of amylases in liquid media using various starchy substances as carbon sources. All rhizobia strains could produce more extracellular protein, biomass and amylases with the different kinds of carbon substrates. Among the carbon sources tested maltose was the best substrate for protein and amylase production. In general, peach palm flour and corn starch (maizena® were also considered to be good carbon sources for rhizobia amylases. On the other hand, the biomass production by the rhizobia isolates was higher in the presence of oat flour. INPA strain R-926 was a good amylase producer in maltose (1.94 U and corn starch (0.53 U media. INPA strain R-991 was also a good amylase producer in maltose (1.66 U and corn starch (1.59 U yielding significant extracellular amylase. Correlation analysis showed significant and positive relationships between rhizobia amylases and final pH (r = 0.49, P Seis isolados de rizobia nativos da Amazonia Central foram selecionados para a produção de amilases em meio de cultura líquido, usando várias substâncias amiláceas como fontes de carbono. Os resultados mostraram que todos os isolados de rizobia podem produzir quantidades diferenciadas de proteína extracelular, biomassa e amilases com diferentes tipos de fontes de carbono. Entre as fontes testadas, maltose foi a melhor para as produções de proteína e amilase. Por outro lado, a produção de biomassa pelos isolados de rizobia foi maior na presença de farinha de aveia. O isolado INPA R-926 mostrou-se um bom produtor de amilase nos meios com maltose (1,94 U e amido de milho (0,53 U. O isolado INPA R-991 também foi um bom produtor de amilase com rendimentos significativos na presença de maltose (1,66 U e amido de milho (1,59 U. As análises de correlação revelaram relações positivas e significativas entre as atividades de amilase e pH final (r = 0,49, P < 0,05, prote

  20. Catálogo florístico y claves de identificación de las ciperáceas de los Estados de Paraíba y Pernambuco (nordeste de Brasil

    Directory of Open Access Journals (Sweden)

    Luceño, Modesto

    1997-06-01

    Full Text Available The present work presents the results of our studies of the family Cyperaceae in the northeastern Brazilian States of Pernambuco and Paraiba. The introduction includes a historical synopsis of previous work and summarizes the main types of vegetation found in the región. Keys for identification of the 22 genera and 127 species which comprise the catalogue are included. The species are enumerated for each genus, along with synonyms which have been employed in the región, material examined, frequency, habitat, general geographic distribution, and taxonomic observations where appropriate. More than half of the species are new records for Pernambuco and Paraiba. Two species are reported as new to science. Fuirena lainzii Luceño & M. Alves (1996 and Scleria pernambucana Luceño & M. Alves (1997. Two species are first reports from the American continent, Pycreus pumilus (L. Nees and P. pelophilus (Ridley C.B. Clarke, and two are first repoits for Brazil, Kyllinga nemoralis (J.R. Forster & G. Forster Dandy ex Hutchinson & Daziel and Scleria mexicana (Liebm. Boeck. Six genera and 10 species are new citations for the northeastem región of Brazil. A lectotype for Cyperus grossianus T.M. Ped. is chosen. Additionally, new localities are given for regional endemisms considered for be rare; other findings represent disjunctions of considerable biogeographical importance.En el presente trabajo se exponen los resultados de las investigaciones que hemos llevado a cabo, sobre la familia de las Ciperáceas, en los Estados brasileños de Pemambuco y Paraíba. En la introducción se presenta una sinopsis histórica de los trabajos anteriores y se resumen las principales formaciones vegetales. Se ofrecen claves para la identificación de los 22 géneros y las 136 especies que componen el catálogo. Tras las claves de cada género se enumeran las diversas especies del mismo, junto con los sinónimos que han sido empleados en la región, materiales examinados

  1. Bromatologic composition of the herbaceous species of the Northeastern Brazil Caatinga Composição bromatológica de espécies herbáceas da caatinga

    Directory of Open Access Journals (Sweden)

    D.S. Silva

    2011-04-01

    Full Text Available The objective of this work was to evaluate the chemical composition of the pool and of four species of caatinga herbaceous vegetation in the rainy and dry seasons. The experiment was conducted in three selected shrub areas at different levels of conservation. Four samples of each species (Arachis pintoi, Boerhavia diffusa, Heliotropium ternatum, Aristida adscensionis were collected in each area and from a pool of species for determination of bromatologic composition. In the dry season, only the pool of species and the grass Aristida adscensionis were evaluated. There was a significant effect of the studied area on the chemical composition of all analyzed species. The nutrient content found in the dry matter (DM and the digestibility of the pool of species indicate that caatinga herbs presented improved quality in the rainy season. The qualitative variables of the studied species were most heterogeneous due to the variability found in caatinga. Conservation conditions in caatinga and season of the year influence bromatologic composition of the species Arachis pintoi, Boerhavia diffusa L., Heliotropium ternatum Vahl. Aristida adscensionis L. and of a pool of typical species found in Caatinga.Com o objetivo de avaliar a composição bromatológica do pool e de quatro espécies da vegetação herbácea da caatinga nos períodos chuvoso e seco foi conduzido um experimento em três áreas selecionadas de caatinga, com níveis diferenciados de conservação. Em cada área, foram colhidas quatro amostras de cada espécie (Arachis pintoi, Boerhavia diffusa, Heliotropium ternatum, Aristida adscensionis e de um pool de espécies, para determinação da composição bromatológica. Na época seca foram avaliados somente o pool de espécies e a gramínea Aristida adscensionis. Houve efeito significativo da área amostrada na composição bromatológica de todas as espécies analisadas. Os teores de nutrientes na matéria seca (MS e a digestibilidade do pool

  2. Efeitos da terra diatomácea sobre Diabrotica speciosa (Germar, 1824 (Coleoptera: Chrysomelidae em batata inglesa Effects of diatomaceous earth on Diabrotica speciosa (Germar, 1824 (Coleoptera: Chrysomelidae in potato

    Directory of Open Access Journals (Sweden)

    Franscinely Aparecida Assis

    2011-06-01

    Full Text Available A espécie Diabrotica speciosa é um crisomelídeo responsável por causar danos consideráveis à batateira, o que torna indispensável seu controle com inseticidas para minimizar os prejuízos causados à cultura. Assim, objetivou-se, com este trabalho, avaliar os efeitos da terra diatomácea sobre o comportamento alimentar e a mortalidade de D. speciosa em batata inglesa em condições de laboratório. Adotou-se o DIC com três tratamentos e oito repetições, sendo: 1 - testemunha; 2 - TD polvilhada (0,5 g/vaso e 3 - TD pulverizada a 1%. As batateiras, cv. Emeraude, foram polvilhadas ou pulverizadas com TD, 30 dias após o plantio e, 24 horas após a aplicação, as plantas foram fornecidas aos insetos, sem e com chance de escolha. Houve diferença significativa entre os tratamentos, sendo a menor porcentagem de folíolos com injúrias observada em plantas que receberam a aplicação de TD pulverizada (teste sem chance de escolha e TD polvilhada ou pulverizada (teste com chance de escolha. Também houve redução do número de injúrias foliares às 24 e às 48 horas (TD polvilhada ou pulverizada e, às 72 horas, a redução foi observada somente com a aplicação da TD polvilhada. Com relação à ação inseticida da TD, foi verificado seu efeito após 48 horas, tanto via polvilhamento, quanto via pulverização. Assim, a aplicação de TD pode auxiliar no manejo de D. speciosa, contribuindo para conferir proteção às plantas de batata inglesa e aumentar a mortalidade desse inseto-praga.The species D. speciosa is a chrysomelid responsible for causing considerable damage on potato plant, making its control with insecticides essential to minimize the damage caused to this culture. The objective of this study was to evaluate the effects of diatomaceous earth (DE on feeding behavior and mortality of D. speciosa in potato under laboratory conditions. A completely randomized design was used with three treatments and eight replicates being: 1

  3. Leguminosas herbáceas perenes para utilização como coberturas permanentes de solo na Caatinga Mineira Perennial herbaceous legumes used as permanent cover cropping in the Caatinga Mineira

    Directory of Open Access Journals (Sweden)

    Ricardo Borges Teodoro

    2011-06-01

    Full Text Available O presente trabalho objetivou avaliar o comportamento e as potencialidades de leguminosas herbáceas perenes para o uso como cobertura permanente em solos da região da Caatinga Mineira, Médio Vale do Jequitinhonha, MG, visando a introdução dessas plantas de cobertura em áreas agrícolas. O experimento foi conduzido de dezembro de 2008 a julho de 2009. O delineamento experimental foi em blocos ao acaso, com seis tratamentos e quatro repetições. Os tratamentos foram constituídos pelas leguminosas: cudzu tropical (Pueraria phaseoloides, calopogônio (Calopogonium mucunoides, amendoim forrageiro (Arachis pintoi, soja perene (Glycine wightii, estilosantes (Stylosanthes capitata, Stylosanthes macrocephala e pela testemunha (sem a presença de leguminosa. Foram avaliados os seguintes parâmetros: emergência das plântulas; taxa de cobertura do solo; promoção da retenção de umidade e temperatura do solo; capacidade de inibição da vegetação espontânea; potencial de deposição de folhas e de aporte de macronutrientes pela senescência de folhas; produção total de fitomassa seca e acúmulo de macronutrientes na parte aérea. A cobertura plena do solo foi alcançada pelo calopogônio, amendoim forrageiro e cudzu tropical. O calopogônio conferiu maior capacidade de retenção da umidade e inibição das plantas espontâneas. Em todos os tratamentos com leguminosas a temperatura do solo foi inferior à testemunha, a partir dos 120 dias de ciclo. Na região da Caatinga Mineira, as leguminosas perenes calopogônio e cudzu tropical, podem contribuir significativamente para o incremento de nitrogênio, aporte de outros macronutrientes (K, P, Ca e Mg e incremento da matéria orgânica do solo.The study objective was to evaluate the performance and potential of perennial herbaceous legumes for use as permanent soil cover in the Caatinga Mineira region MG, Brazil, for the introduction of these cover crops in agricultural areas. The experimental

  4. Enraizamento de estacas herbáceas do porta-enxerto de videira 'Riparia de Traviú' tratadas com auxinas Rooting of herbaceous cuttings of the grape rootstock 'Riparia de Traviú' treated with auxinas

    Directory of Open Access Journals (Sweden)

    Fabíola Villa

    2003-12-01

    Full Text Available Estudou-se o efeito do ácido indol-butírico (AIB e ácido naftalenoacético (ANA no enraizamento de estacas do porta-enxerto de videira 'Riparia de Traviú', resultantes da desbrota realizada em plantas situadas no local definitivo, antes de serem enxertadas, visando à obtenção antecipada de novos porta-enxertos. O experimento foi conduzido em casa-de-vegetação com 50% de sombrite, temperatura e nebulização controladas, no pomar didático da Universidade Federal de Lavras - UFLA. As estacas herbáceas desprovidas de folhas e com comprimento de 15 cm e 8 mm de diâmetro foram imersas em soluções AIB e ANA (0, 1000, 2000, 3000 e 4000 mg.L-1 por 15 segundos e, em seguida, colocadas em bandejas de isopor preenchidas com substrato vermiculita. Após 60 dias, coletaram-se os seguintes dados biométricos: porcentagem de estacas enraizadas e brotadas, número de folhas e brotos, comprimento médio das raízes e biomassa seca das brotações. Não houve efeito significativo das concentrações AIB e ANA para todas as características analisadas. Para a característica porcentagem de estacas enraizadas, obtiveram-se 56,73% de enraizamento sem aplicação de auxinas, podendo esse método resultar na antecipação da obtenção de novos porta-enxertos, utilizando-se material resultante da desbrota.The effect of the indol butiric acid (IBA and the naftalenoacetic acid (NAA in the rooting of 'Riparia de Traviú' cuttings obtained from the sproutings of the plants, before being grafted, in order to obtain new rootstocks. The experiment was conduted under green house conditions, at the orchard of the Lavras Federal University (UFLA. The herbaceous cuttings, measuring 15 cm of lengh 8 mm of diameter and without leaves, were treated with IBA and NAA (0, 1000, 2000, 3000 and 4000 mg.L-1 for 15 seconds and taken to polystyrene trays filled with vermiculita. After 60 days, the percentage of rooting and sprouted cuttings, the number of leaves and sprouts

  5. Value of Combined Detection of Tumor Markers Such as CEA and CA125 in the Diagnosis of Lung Cancer%CEA、CA125等肿瘤标志物联合检测在肺癌诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    李林; 王迪进; 万轲; 徐国辉

    2015-01-01

    Objective To study the value of serum carcinoembryonic antigen ( CEA ) , carbohydrate antigen 125 (CA125),cytokeratin 19 fragments (CYFRA21-1),neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCC) in the diagnosis of lung cancer.Methods 102 cases of lung cancer patients,65 cases of lung benign diseases and 80 cases of healthy patients were randomly selected.5ml peripheral venous blood was extracted from every research object and the SCC,NSE, CA125,CYFRA21-1 and CEA were detected.Results The positive rates of SCC,NSE,CA125,CYFRA21-1 and CEA of patients in lung cancer group were significantly higher than those in other 2 groups(P<0.05).The sensitivity of 5 tumor markers com-bined detection in the diagnosis of lung cancer (91.18%) was significantly higher than each one of CEA,CA125,CYFRA21-1, NSE and SCC(40.20%,42.16%,50.00%,36.27%,20.59%)(P<0.05).Conclusion CEA,CA125,CYFRA21-1,NSE and SCC have certain value in the clinical diagnosis and classification of lung cancer,and the combined detection of the 5 tumor mark-ers can significantly increase the sensitivity.%目的:探讨癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白19片段21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)以及鳞状上皮细胞癌相关抗原(SCC)5种肿瘤标志物联合检测在肺癌诊断中的价值。方法随机选择肺癌患者102例、肺良性疾病65例以及同期体检健康者80例作为研究对象。所有研究对象均于空腹抽取5 ml外周静脉血,检测CEA、CA125、CYFRA21-1、NSE和SCC浓度。结果肺癌组患者CEA、CA125、CYFRA21-1、NSE及SCC检测阳性率均显著高于肺良性疾病患者、健康组(P<0.05);5种肿瘤标志物联合检测诊断肺癌的敏感度(91.18%)显著高于CEA、CA125、CYFRA21-1、NSE及SCC单项检测敏感度(42.20%、42.16%、50.00%、36.27%、20.59%)(P<0.05)。结论CEA、CA125、CYFRA21-1、NSE及SCC在肺

  6. Evaluating the value of CEA and CA153 during follow-up in HER-2 overexpressing breast cancer u-sing ROC curves%利用 ROC 曲线评价 CEA、CA153在 HER -2阳性乳腺癌术后随访中的价值

    Institute of Scientific and Technical Information of China (English)

    侯军君; 任立瑾; 高媛媛; 刘潇莲; 蔡莉

    2014-01-01

    目的:用ROC曲线评价CEA及CA153监测HER-2阳性乳腺癌患者术后复发转移的价值,并确立诊断HER-2阳性乳腺癌患者术后复发转移的最佳临界值。方法收集127例HER-2阳性乳腺癌患者CEA及CA153数值,将其分为复发转移及未复发转移两组。绘制ROC曲线,找到最佳临界值,同时比较最佳临界值与常规诊断值诊断复发转移的优劣。结果复发转移组较未复发转移组CEA及CA153水平显著偏高(P<0.0001),CEA、CA153诊断复发转移ROC曲线下面积分别为0.752、0.820,对应的最佳临界值分别为3.5 ng/mL、17.89 U/mL。 CEA和CA153最佳临界值敏感性分别为46.15%、65.38%,CEA和CA153最佳临界值特异性分别为97.33%、89.33%。结论 CEA、CA153在HER-2阳性乳腺癌患者术后判断复发转移中具有中等价值,诊断术后复发转移的最佳临界值分别为3.5 ng/mL、17.89 U/mL。%Objective To explore the value of carcinoembryonic antigen ( CEA) and cancer antigen 153 ( CA153 ) in detecting tumor recurrences and to establish the optimal operating point of diagnosis of recurrences in HER-2 overexpressing breast cancer using ROC curves .Methods A total of 127 HER -2 overexpressing breast cancer patients was enrolled into this study and subdivided into two groups ,the recurrence group and the non-recurrence group .We created a ROC curve and found out the optimal operating point .Then we compared the advantage of detecting recurrences between optimal operating point in the ROC curve and the diagnostic point that we usually used .Results The recurrence groups showed significantly higher CEA and CA 153 levels than the non-recurrence groups(P<0.0001).The area under the curve(AUC)of the CEA and CA153 were 0.752 and 0.820 respectively and the optimal operating point were 3.5 ng/mL and 17.89 U/mL,respectively.The sensitivi-ties of the optimal operating point of CEA and CA 153 were 46.15%and 65.38%respectively

  7. Prognosis evaluation value of serum CYFRA21-1 and CEA level in non-small cell lung cancer:Meta analysis%血清CYFRA21-1和CEA对非小细胞肺癌预后评价价值的Meta分析

    Institute of Scientific and Technical Information of China (English)

    邓伟伟; 黄艳春

    2014-01-01

    Objective To evaluate the clinical significance of serum cytokeratin 19 fragment (CYFRA21-1) and carcinoma embryonic antigen(CEA) prognosis in non-small cell lung cancer(NSCLC) patients.MethodsAll the data dealing with the significance of serum CYFRA21-1 and serum CEA prognosis of NSCLC was researched from PubMed, Springer Link and Du Xiu database.The outcome was measured using the hazard ratio(HR). Data pooling was performed by RevMan 5.1.Results One thousand five hundred and sixty-nine patients from 8 studies were included in the meta analysis. Merger HR estimate of overall survival for NSCLC patients with high serum CYFRA21-1 level was 1.63 (95%CI: 1.43-1.85,P<0.05). Merger HR estimate of overall survival for NSCLC patients with high serum CEA level was 1.45 (95%CI: 1.26-1.66,P<0.05).ConclusionSerumCYFRA21-1 and CEA can be regarded as a prognostic indicator of evaluation of NSCLC, high serum CYFRA21-1 in evaluation of NSCLC with poor prognosis is more valuable than high serum CEA, jointing detection will be more reliable.%目的:研究血清细胞角蛋白19片段(CYFRA21-1)和癌胚抗原(CEA)对非小细胞肺癌(NSCLC)患者的临床预后意义。方法通过检索PubMed、Springer Link、超星读秀中有关研究血清CYFRA21-1和CEA对NSCLC患者预后影响的文献,采用RevMan5.1软件进行荟萃分析(Meta分析),合并值为风险比(HR)。结果共入选8篇文献,累计NSCLC患者1569例。所有高水平血清CYFRA21-1的NSCLC患者的总生存估计合并HR=1.63[95%可信区间(95%CI):1.43~1.85, P<0.05],所有高水平血清CEA的NSCLC患者的总生存估计合并HR=1.45(95%CI:1.26~1.66, P<0.05),差异均有统计学意义。结论血清CYFRA21-1和CEA可作为NSCLC患者的预后评价指标,高血清CYFRA21-1较高血清CEA对评价NSCLC患者的预后不良更有价值,联合检测将更可靠。

  8. Extraction and anticoagulant activity of sulfated polysaccharides from Caulerpa cupressoides var. lycopodium (Vahl C. Agardh (Chlorophyceae = Extração e atividade anticoagulante dos polissacarídeos sulfatados da clorofícea Caulerpa cupressoides var. lycopodium (Vahl C. Agardh = Extração e atividade anticoagulante dos polissacarídeos sulfatados da clorofícea Caulerpa cupressoides var. lycopodium (Vahl C. Agardh.

    Directory of Open Access Journals (Sweden)

    José Ariévilo Gurgel Rodrigues

    2011-04-01

    Full Text Available The reportedly low standard quality of heparin (HEP for use in cardiac surgeries has led to concern in the Brazilian and international markets. Sulfated polysaccharides (SPs from seaweeds have been regarded as promising substitutes for HEP. The aim of this study was to sequentially extract total SPs (TSPs from Caulerpa cupressoides (Chlorophyceae with papain in 100 mM sodium acetate buffer (pH 5.0 containing 5 mM cysteine and 5 mM EDTA, followed byfractionation by ion-exchange chromatography (DEAE-cellulose, and then evaluate the anticoagulant potential of SP fractions by activated partial thromboplastin time (APTT using normal human plasma and compare it to standard HEP (193 IU mg-1. The obtained fractions were chemically characterized by chemical composition and agarose gel electrophoresis. The yield was 4.61%, and three fractions of SP (F I, F II and F III eluted with 0.50, 0.75 and 1.00 M of NaCl,respectively, were observed on chromatography profiles; however, differences in charge densities patterns and degree of resolution among them were revealed by electrophoresis. SPs were capable of modifying APTT only in fractions eluted with 0.75 M of NaCl, whose activities were 23.37 and 25.76 IU mg-1, respectively, and the charge density was prerequisite to activity. Therefore, C. cupressoides is a source of SPs possessing low anticoagulant potential compared to HEP.O baixo padrão de qualidade outrora declarado da heparina (HEP para o uso em cirurgias cardíacas tem levado preocupação nos mercados nacional e internacional. Os polissacarídeos sulfatados (PSs de algasmarinhas têm sido considerados como promissores substitutos para HEP. Objetivou-se a extrair sequencialmente PSs totais (PSTs da clorofícea Caulerpa cupressoides com papaína em tampão acetato de sódio 100 mM (pH 5,0 contendo cisteína 5 mM e EDTA 5 mM, fracionar por cromatografia de troca iônica (DEAE-celulose e avaliar o potencial anticoagulante das frações de PS por meio do

  9. CA153与CEA在三阴乳腺癌及非三阴乳腺癌预后中的比较分析%Serum CA153 and CEA for prognosing triple negative and non-triple-negative breast cancer

    Institute of Scientific and Technical Information of China (English)

    黄江玲; 邱少雄; 肖亮生; 陈乐川; 杨馥彦

    2015-01-01

    Objective To explore the differences in the serum levels of CA153 and CEA between triple negative and non-triple-negative breast cancer and to analyze the correlation between the serum levels of CA153 and CEA and the patients' prognosis.Methods 120 patients with triple negative breast cancer (triple negative group) and 575 patients with non-triple-negative breast cancer (non-triple-negative group) diagnosed by clinical pathology were selected and their serum levels of CA153 and CEA were detected by electrochemical luminescence.The correlation between these two indicators' serum levels and the patients' overall survival (OS) and progression-free surial (PFS) was analyzed.Results The serum level of CA153 was (47.06±45.63)U/ml in the triple negative group and was significantly higher than that in the non-triple-negative group[(30.38±28.57) U/ml],with a statistical difference(P<0.01).The serum level of CEA was (10.11±9.54)U/ml in the triple negative group and higher than that in the non-triple-negative group[(7.03±6.87)ng/ml] (P < 0.05).5 years' survival analysis showed that the patients with triple negative breast cancer whose serum CA 153 < 47.06 U/ml and CEA < 10.11 ng/ml and the patients with non-triplenegative breast cancer whose serum CA153< 30.38 U/ml and CEA < 7.03 ng/ml has advantage in OS and PFS,with statistical differences(P < 0.05).Conclusions CA153 and CEA can be used as predictors for prognosing triple negative and non-triple-negative breast cancer.%目的 探讨血清CA153与CEA在三阴乳腺癌及非三阴乳腺癌中表达水平的差异,并分析血清中CA153与CEA水平差异与患者预后情况的关系.方法 选取2005年1月至2012年6月经临床病理学确诊的三阴乳腺癌患者120例(三阴组)及非三阴乳腺癌患者575例(非三阴组),采用电化学发光法检测两组患者血清CA153、CEA含量,并分析这两种肿瘤标志物水平变化与患者总生存期、无进展生存期的关系.结果

  10. CK19mRNA、CEA 和 CA199对结直肠癌预后判断的价值及在随诊中的意义%The Value of Prognosis and Significance of follow up in Colorectal Cancer Patients of Peripheral Blood CK19mRNA、CEA、CA19-9

    Institute of Scientific and Technical Information of China (English)

    高继绪

    2013-01-01

    目的:探讨 CK19mRNA、CEA 和 CA199对结直肠癌预后判断的价值及在随诊中的意义。方法:收集76例结直肠癌患者、35例结直肠良性疾病患者和20例健康献血员的外周血细胞,分别抽提 RNA,逆转录聚合酶链反应法测定 CK19mRNA 水平;收集上述病例外周血血浆,电化学发光法检测 CEA,CA199含量。数据分别以 t 检验和 x2检验进行统计学处理。结果:三联检测的灵敏度、约登指数最高。结论:结直肠癌患者外周血 CK19mRNA、CEA、CA199联合检测可起到互补作用,明显提高检测的灵敏度和约登指数,能较好的提高大肠癌患者的阳性率,帮助临床大夫选择合理的治疗方案,综合判断预后,在随诊中及早发现复发。%Objective:To explore the value of prognosis and significance of fol ow up in colorectal cancer patients of peripheral blood CK19mRNA、CEA、CA19-9.Methods:With the application of reverse transcription polymerase chain reaction(RT-PCR)and ECLIA,test the level of peripheral blood CK19mRNA、CEA、CA19-9,Do testing for 76cases of colorectal cancer patients, 35 cases of benign lung diseases patients and 20 health blood donors.For data statistics, apply t-test and x2-test. Results :The joint detection sensitivity, about the highest .Conclusion:The joint detection of colorectal cancer patients of peripheral blood CK19mRNA,CEA,CA19-9 can play a complementary role and notably promote the sensitivity and youden index of peripheral blood testing, but specificity with no significant decline.The joint detection has important clinical significance in prognosis, treatment and recurrence of colorectal cancer.

  11. The principal nuclear wastes paths at the Cea; Les principales filieres de dechets nucleaires au CEA

    Energy Technology Data Exchange (ETDEWEB)

    Toly, J.A. [CEA Saclay, Dir. du Patrimoine et de l' Assainissement DPA, 91 - Gif sur Yvette (France)

    2001-07-01

    The different channels of radioactive waste are detailed, the objectives, the particularities, the costs for the different paths are reviewed, and the question of the waste acceptance by the public is a part in the choice of solutions. (N.C.)

  12. Combination of diatomaceous earth and powder deltamethrin for insect control in stored corn Combinação de terra de diatomácea e deltametrina em pó para o controle de insetos em milho armazenado

    Directory of Open Access Journals (Sweden)

    Fabiane Cristina Ceruti

    2005-12-01

    Full Text Available The use of diatomaceous earth (DE is a very efficient insect control measure in stored grain IPM due to its low cost, easy application, reduction of active ingredient residues, lower environmental contamination and operator safety. The objective of this research was to evaluate the efficacy of different dosages of DE mixed with powder deltamethrin for controlling Sitophilus zeamais in stored corn. Samples of 100 g of clean and dry corn, in three replicates, were submitted to the following treatments: DE (Keepdry®, at the dosages of 500, 750 and 1000 g/t; powder deltamethrin (K-Obiol® at 0,5 g a.i. /t and 1,0 g a.i. /t; and combinations of the lowest and highest DE dosages with the two dosages of deltamethrin. Thirty adults of S. zeamais were placed in each vial with the treated grains and kept in environment chambers at 25ºC. Mortality was evaluated from the 1st to the 28th day. In the treatments mixing DE with deltamethrin or deltamethrin alone, the mortalyti was registered since the first day. In the treatments using only DE, the first dead insects were recorded after the 3rd day, especially in the highest dosages. After the 7th day, however, there was no statistical difference among all treatments, except for the lowest dosage of DE which reached a satisfactory control level only by the 14th day. It was concluded that treatments using DE combined with low dosages of powder deltamethrin represent an efficient control measure against S. zeamais in stored corn because insect mortality is faster than in treatments using DE alone and residues of active ingredients are much lower than using the insecticide in high dosages.O uso de terra de diatomácea (TD representa uma medida de controle importante em programas de MIP de armazenamento devido ao baixo custo, facilidade de aplicação, redução do nível de resíduos de ingrediente ativo e da contaminação ambiental e maior segurança para o operador. O objetivo desta pesquisa foi avaliar a

  13. Adubação nitrogenada e potássica de bromeliáceas cultivadas em fibra de coco e esterco bovino Nitrogen and potassium fertilization of Bromeliaceae grown in coconut fiber and cattle manure

    Directory of Open Access Journals (Sweden)

    Tatiana L do Amaral

    2009-09-01

    Full Text Available Neste trabalho objetivou-se avaliar o efeito de doses de nitrogênio e de potássio no crescimento e teor foliar de nutrientes de quatro bromeliáceas comerciais e propor uma formulação de adubação adequada para cada planta estudada. O experimento foi em esquema fatorial (4 x 4, sendo quatro doses de nitrogênio (0; 375; 562,6 e 750 mg de N L-1 e quatro doses de potássio (0; 468,8; 703,2 e 937,6 mg de K L-1, em delineamento em blocos ao acaso, com quatro repetições para Aechmea blanchetiana e Neoregelia 'Sheba' e três repetições para Orthophytum gurkenii e Vriesea gigantea, duas plantas por parcela. As mudas de Aechmea blanchetiana e Neoregelia 'Sheba' foram cultivadas em substrato composto por 50% de fibra de coco + 50% de esterco bovino; as de Orthophytum gurkenii e Vriesea gigantea, em 100% de fibra de coco. As doses de nitrogênio 0; 375; 562,6 e 750 mg de N L-1 e potássio 0; 468,8; 703,2 e 937,6 mg de K L-1 no substrato correspondem, respectivamente, a 0; 187,5; 281,3 e 375 mg N/planta e 0; 234,4; 351,6 e 468,8 mg K/planta. A adubação fosfatada foi fixa, 50 mg de P L-1 no substrato, correspondendo a 25 mg P/planta, exceto para Neoregelia 'Sheba', que foi inoculada com 25 mL/vaso do inóculo micorrízico misto (Glomus geosporum, Acaulospora laevis, Acaulospora mellea e não recebeu adubação fosfatada. A adubação com 305,1 mg N/planta foi a que proporcionou maior incremento na altura de Aechmea blanchetiana. Em Orthophytum gurkenii; a adubação com 250 mg N/planta proporcionou o maior número de folhas e o maior diâmetro da roseta. As adubações nitrogenada e potássica não beneficiaram o crescimento das plantas de Vriesea gigantea. Em Neoregelia 'Sheba', a dose de 315 mg N/planta causou maior incremento em altura e diâmetro da roseta.Levels of nitrogen and potassium fertilization were evaluated on leaf nutrient contents of four commercial bromeliads, to recommend a suitable fertilization formula for each kind of plant

  14. Capacidade reprodutiva e preferência da traça-das-crucíferas para diferentes brassicáceas Reproductive capacity and preference of the diamondback moth feeding on different brassicacea

    Directory of Open Access Journals (Sweden)

    Sergio A De Bortoli

    2011-06-01

    Full Text Available O objetivo desta pesquisa foi comparar diferentes cultivares de brassicáceas em relação à capacidade reprodutiva e preferência para alimentação e oviposição da traça-das-crucíferas. Os experimentos foram realizados utilizando-se as cultivares de repolho Midori, Chato-de-Quintal, híbridos da Top Seed® - Agristar (TPC 308, TPC 681 e TPC 668, couve-flor Bola de Neve, couve brócolis Ramoso Piracicaba Precoce e couve Manteiga da Geórgia, sendo esta última utilizada como padrão de suscetibilidade. Por meio dos dados biológicos de P. xylostella foram estimados os parâmetros necessários para a construção de tabela de vida de fertilidade, para comparação das cultivares testadas em relação à capacidade reprodutiva da praga. Em gaiolas de criação da traça-das-crucíferas foram colocados quatro quartos de folha, dois a dois, que justapostos formavam um círculo de 8 cm de diâmetro, confrontando-se os materiais dois a dois. As partes foram dispostas equidistantemente, para realização do teste de dupla chance de escolha (preferência para alimentação e oviposição e de múltipla chance de escolha, confrontando todos os substratos (preferência para alimentação. As cultivares que proporcionaram melhor desenvolvimento e reprodução para a traça-das-crucíferas foram couve Manteiga da Geórgia e couve brócolis. Para preferência alimentar constatou-se alta suscetibilidade em couve Manteiga e TPC 681 e para preferência de oviposição alta preferência para couve-flor Bola de Neve. Com isso, sugere-se a divisão das cultivares estudadas em quatro classes distintas: repolho Midori como moderadamente resistente (MR; couve-flor Bola de Neve e repolho Chato-de-Quintal como suscetíveis (S; couve brócolis, TPC308, TPC681 e TPC668 como moderadamente suscetíveis (MS; e couve Manteiga como altamente suscetível (AS.We compared different cultivars of crucifer in relation to reproductive capacity and preference for feeding and

  15. The significance of MT, VEGF, CA125, CEA and MMP-9 combine detection in NSCLC diagnosis%联合检测外周血CEA、CA125、VEGF、MT及MMP-9在晚期非小细胞肺癌诊断中的意义

    Institute of Scientific and Technical Information of China (English)

    丁瑞敏

    2015-01-01

    目的:探讨外周血金属硫蛋白(metallothionein, MT)、血管内皮细胞生长因子(vascular endothelial growth factor, VEGF)、糖链抗原125(carbohydrate antigen 125, CA125)、癌胚抗原(carcinoem-bryonic antigen, CEA)和基质金属蛋白酶-9(matrix metalloprotein-9, MMP-9)5项指标联合检测对晚期非小细胞肺癌(non-small-cell lung carcinoma, NSCLC)的诊断价值。方法选择2012年6月至2014年6月于我院就诊的NSCLC 患者80例及健康对照者72例为研究对象,检测受试者血清 MT、VEGF、CA125、CEA和MMP-9水平,对检测结果进行统计学分析。结果 NSCLC组MT、VEGF、CA125、CEA和MMP-9的检测结果均高于对照组,且差异均有统计学意义(P均<0.05)。5项指标联合检测的灵敏度和特异性均高于各指标单独检测的灵敏度和特异性。结论 MT、VEGF、CA125、CEA和MMP-9的检测可用于晚期NSCLC的辅助诊断,其联合检测可明显提高NSCLC的检出率。%Objective To analysis the significance of peripheral blood metallothionein(MT), vascular endothelial growth factor(VEGF), carbohydrate antigen 125(CA125), carcinoembryonic antigen(CEA), and matrix metalloprotein-9 (MMP-9) combine detection in advanced stage non-small-cell lung carcinoma (NSCLC) diagnosis. Methods 80 cases patients with advanced stage NSCLC and 72 cases healthy control people from June 2012 to June 2014 in our hospital were collected. The MT, VEGF, CA125, CEA and MMP-9 serum levels of all subjects were all detected and the results were analyzed statistically. Results The serum levels of MT, VEGF, CA125, CEA and MMP-9 in NSCLC group were all higher than that of control group, and the differences all had statistical significance (Pall< 0.05). The sensitivity and specificity of 5 index combine detection were all higher than that of each index alone detection. Conclusion The detection of MT, VEGF, CA125, CEA and MMP-9 can be used in the

  16. Resposta de Sitophilus oryzae (L., Cryptolestes ferrugineus (Stephens e Oryzaephilus surinamensis (L. a diferentes concentrações de terra de diatomácea em trigo armazenado a granel Response of Sitophilus oryzae (L., Cryptolestes ferrugineus (Stephens and Oryzaephilus surinamensis (L. to different concentrations of diatomaceous earth in bulk stored wheat

    Directory of Open Access Journals (Sweden)

    Airton Rodrigues Pinto Júnior

    2008-11-01

    Full Text Available Formulações de terra de diatomácea de diferentes origens apresentam variação em toxicidade e em características físicas que afetam sua eficácia. Da mesma forma, diferentes espécies de insetos variam quanto a sua suscetibilidade ao produto. Adultos de Sitophilus oryzae (L., Cryptolestes ferrugineus (Stephens e Oryzaephilus surinamensis (L. foram expostos a concentrações de 250, 500, 750, 1000 e 1250g t-1 de uma formulação de terra de diatomácea de origem brasileira (Keepdry®, em trigo armazenado, por diferentes períodos de exposição. Os grãos tratados com as diferentes concentrações foram colocados em frascos, com quatro repetições de 100g de grãos por tratamento, e infestados com os insetos. Os frascos foram mantidos em câmara climatizada a 25°C e 65% UR, avaliando-se a mortalidade periodicamente. O número de insetos mortos por parcela foi submetido à análise de variância e as diferenças entre as médias discriminadas pelo teste de Tukey a 5%. A mortalidade das três espécies foi diretamente relacionada à concentração e ao tempo de exposição, sendo que os melhores resultados foram obtidos com concentrações acima de 500g t-1. A espécie S. oryzae atingiu 100% de mortalidade somente no 14° dia de exposição, na concentração de 750g t-1. C. ferrugineus foi a espécie mais suscetível ao tratamento com a terra de diatomácea, com 100% de mortalidade a 500g t-1 já no 4° dia. Conclui-se que a terra de diatomácea utilizada apresenta um nível de controle satisfatório, e pode ser utilizada em programas de manejo de insetos, em trigo armazenado.Formulations of diatomaceous earth from different sources show variation in toxicity and in certain physical characteristics which can affect product efficacy. Also, different insect species show variation in their susceptibility to the product. Adults of Sitophilus oryzae (L., Cryptolestes ferrugineus (Stephens and Oryzaephilus surinamensis (L. were exposed to wheat

  17. 肺癌临床分期与肿瘤标志物CEA、CA15-3、NSE和CYFRA21-1相关性分析%Correlation analysis of lung cancer staging and tumor markers CEA, CA15-3, NSE and CYFRA21-1

    Institute of Scientific and Technical Information of China (English)

    聂书伟; 吕勇刚; 易军

    2012-01-01

    Objective To study the correlation between serum tumor marker carcinoembryonic antigen (CEA) , carbohydrate antigen 15-3 (CA15-3) , neuron-specific enzyme diluted alcohol (NSE) , cytokeratin 19 fragment (CYFRA21-1) and clinical staging of lung cancer, and discuss its clinical significance. Methods One hundred and sixty-Bix cases of lung cancer was diagnosed by pathology or cytology, including 81 cases of adenocarcinoma, 44 cases of squamous cell carcinoma, 14 cases of small cell carcinoma, 12 cases of adenosquamous carcinoma, 11 cases of combined small cell carcinoma and 4 cases of other; non metastasis in 109 cases and metastasis in 57 cases. 36 cases of health people in health checks in the hospital at same period were as normal controls. Serum CEA, CA15-3, NSE and CYFRA21-1 levels were measured by -y radioimmunoassay in patients with lung cancer and normal controls; and compared with lung cancers staging, metastasis and without metastasis in the expression levels and positive rate of tumor markers, and the correlations were analyzed. Results There was lung cancer of clinical stage, including I stage 10. 24% (17/166), II stage 7.23% (12/166), III stage 36.75% (61/166) and IV stage 45.78% (76/166). With the staging of lung cancer increased serum levels of tumor markers (CEA, CA15-3 and CYFRA21-1) were rising trend (P<0. 05) , the later stages of lung cancer, the higher the positive rate of tumor markers (P < 0. 05). Lung cancer metastasis was diagnosed in 57 (27.67%) patients, tumor marker levels after the metastasis were significantly higher than those without metastasis (P < 0.01). The control group and lung cancer patients were observed as the object, the combination tests of CEA, CAl 5 -3, NSE and CYFRA21 -1 levels werebetter than single test, and sensitivity (71. 93 % ) increased, false negative (28.07%) was lower, but specificity (97.25%) and false positive (2. 75% ) had no significant change. Conclusion The detection of CEA, CA15-3, NSE and CYFRA21

  18. 99Tcm-HL91乏氧显像联合血清CYFRA21-1、NSE、CEA检测对肺癌的诊断价值%The Clinical Value of 99Tcm-HL91 Hypoxia Imaging Combined with the Detection of Serum NSE, CEA and CYFRA21-1 in the Diagnosis of Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    李晓红; 王迎秋; 孙高峰; 张桉瑜; 左长京

    2012-01-01

    Objective To investigate the value of 99Tcm-HL91 hypoxia imaging combined the detection of serum neuron-specific enolase (NSE) , careinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA21-1) in the diagnosis of lung cancer. Methods 63 patients with lung neoplasm were carried out 99Tcm-HL91 hypoxia imaging, and the serum tumor markers levels of NSE, CEA and CYFRA21-1 were detected. The sensitivity, specificity and accuracy of each and combined method were calculated respectively and compared with each other. Results The sensitivity, specificity and accuracy in diagnosis of lung cancer with 99Tcm-HL91 hypoxia imaging were 85. 4%, 100% and 88. 9% respectively; and with serum tumor markers NSE, CEA and CYFRA21-1 detection were 72.9% , 86.7% and 76.1% respectively. Compared with the detection of serum tumor marker levels of NSE, CEA and CYFRA21-1, 99Tcm-HL91 hypoxia imaging had the higher sensitivity and specificity, and similar accuracy. The sensitivity, specificity and accuracy of combined two methods in diagnosis of lung cancer were 95. 8% , 86.7% and 93.6% respectively. The sensitivity and accuracy of the combined method were significantly increased than single method ( P 0.05). Conclusion 99Tcm-HL91 hypoxia imaging and the detection of serum level of NSE, CEA and CYFRA21-1 have an important diagnostic value, and their combination could improve the sensitivity and accuracy in the diagnosis of lung cancer.%目的 探讨99Tcm-HL91乏氧显像和血清细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)检测及其联合应用诊断肺癌的价值.方法 选择肺部肿瘤患者63例,全部行99Tcm-HL91乏氧显像和血清CYFRA21-1、NSE、CEA三种肿瘤标志物检测,分别计算两种方法及两种方法联合诊断肺癌的灵敏度、特异性和准确率并加以比较.结果 99Tcm-HL91乏氧显像诊断肺癌的灵敏度为85.4%、特异性为100%、准确率为88.9%,CYFRA21-1、NSE、CEA联合

  19. CYFRA21-1、CEA、NSE和CA125联合检测在非小细胞肺癌中的诊断价值%The Diagnostic Value of Combined Detection of CYFRA21-1,CEA,NSE and CA125 in Non Small Cell Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    邢国燕; 赵树波

    2016-01-01

    Objective:To discuss the diagnostic value of combined detection of CYFRA21-1,CEA, NSE and CA125 in non small cell lung cancer.Method:92 cases of NSCLC and 95 cases of lung benign lesions from January 2010 to June 2015 in our hospital were selected as the research objects,92 cases of NSCLC were divided into 42 cases of lung squamous cell carcinoma group and 50 cases of lung adenocarcinoma group according to the different pathological types.The levels of CYFRA21-1, CEA, NSE and CA125 in all patients were measured by electrochemical luminescence method.Result:The CYFRA21-1,CEA,NSE and CA125 in NSCLC group were significantly higher than those in benign lung disease group,the differences were statistically significant (P<0.05).The sensitivity and specificity of CYFRA21-1 were respectively 71.40% and 89.10% in lung squamous cell carcinoma group,the sensitivity and specificity of CEA were respectively 60.00% and 84.30% in lung adenocarcinoma group.The sensitivity of CYFRA21-1 in the diagnosis of NSCLC was 46.53%,specificity was 85.26%.The sensitivity of CEA in the diagnosis of NSCLC was 42.58%,specificity was 81.05%.The sensitivity of NSE in the diagnosis of NSCLC was 57.43%,specificity was 76.85%.The sensitivity of CA125 in the diagnosis of NSCLC was 48.51%,specificity was 66.32%.Combined determination of the four parameters sensitivity was 93.26%,specificity was 98.25%.Conclusion:CYFRA21-1,CEA,CA125 and NSE have certain value for the early detection and diagnosis of NSCLC,and the combined detection of the four has obvious complementarity, which can significantly improve the diagnostic rate of NSCLC.%目的:探讨细胞角蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、糖类抗原125(CA125)联合检测在非小细胞肺癌(NSCLC)中的诊断价值。方法:选取2010年1月-2015年6月本院收治的NSCLC患者92例和肺部良性病变患者95例作为研究对象,92例NSCLC患者根据病理类

  20. Diagnostic value of combinative detection of serum carcinoembryonic antigen(CEA),adenosine deaminase(ADA),lactate dehydrogenase(LDH) and ESR in differential diagnosis of pleural effusion%联合检测CEA、ADA、LDH及血沉对胸腔积液性质判断的临床意义

    Institute of Scientific and Technical Information of China (English)

    夏静; 闫雪波; 刘荣玉

    2013-01-01

    Objective To establish the diagnostic value of combinative detection of serum CEA,serum and pleural fluid LDH,pleural fluid ADA and ESR in different pleural effusion patients. Methods From December 2011 to June 2012 ,89 cases of in-patients with pleural effusion in the First Affiliated Hospital of Anhui Medical University were chosen,including 25 cases of tuberculous effusion( TE ),42 patients with malignant pleural effusion( MPE ) and 22 cases of inflammatory patients with pleural effusion( IPE ). The levels of serum CEA were examined by electrochemilumin-escence immunoassay method, serum LDH by the enzymatic( L method ), pleural fluid LDH and ADA by rating method and ESR by Westergren. Results The serum CEA of malignant pleural effusion patients is higher than that of TE and IPE patients;The serum and pleural fluid LDH levels in TE,MPE,IPE patients showed no significant difference,but the three pleural effusion LDH levels were significantly higher than the normal range, and the ratio of pleural effusion and serum LDH in patients with TE was significantly higher than that of patients with MPE; The pleural fluid ADA levels of TE were significantly higher than those of the MPE and IPE; The IPE patients ESR levels were significantly higher than those of TE and MPE patients, and ESR levels of TE patients were significantly higher than those of MPE patients. Conclusion Combined detection of serum CEA, pleural fluid and serum LDH, pleural fluid ADA and ESR has great significance in judging the nature of pleural fluid.%目的 探讨联合检测血清癌胚抗原(CEA)、血清及胸水乳酸脱氢酶(LDH)、胸水腺苷脱氨酶(ADA)及血沉对胸腔积液性质判断的临床意义.方法 以安徽医科大学第一附属医院2011年12月至2012年6月89例住院胸腔积液患者为研究对象,其中25例结核性胸腔积液患者,42例恶性胸腔积液患者,22例炎性胸腔积液患者;采用电化学发光免疫分析法测定血清CEA,酶法(L法)测定血

  1. Fission product plateout/liftoff/washoff test plan. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Acharya, R.; Hanson, D.

    1988-05-01

    A test program is planned in the COMEDIE loop of the Commissariat a l`Energy Atomique (CEA), Grenoble, France, to generate integral test data for the validation of computer codes used to predict fission product transport and core corrosion in the Modular High Temperature Gas-Cooled Reactor (MHTGR). The inpile testing will be performed by the CEA under contract from the US Department of Energy (DOE); the contract will be administered by Oak Ridge National Laboratory (ORNL). The primary purpose of this test plan is to provide an overview of the proposed program in terms of the overall scope and schedule. 8 refs, 3 figs.

  2. L'expérience MUSE-4 : Mesure des paramètres cinétiques d'un système sous-critique

    OpenAIRE

    Vollaire, Joachim

    2004-01-01

    Expérience Muse-4; Accelerator Driven System (ADS) which are based on an external neutron source coupled to a subcritical core, offer advantages for the incineration of radioactive waste. In order to understand the neutronic specificity of such a system, during the MUSE IV experimental program, the experimental reactor MASURCA (CEA Cadarache) has been coupled to the neutrons source GENEPI which has been developed at the LPSC Grenoble. This setup has enabled the development of an on-line measu...

  3. Operation of the GTS-LHC Source for the Hadron Injector at CERN%CERN用于强子研究加速器系统离子注入的离子源GTS-LHC运行状况

    Institute of Scientific and Technical Information of China (English)

    L.Dumas; C.Hill; D.Hitz; D.Küchler; C.Mastrostefano; M.O'Neil; R.Scrivens

    2007-01-01

    The GTS-LHC ion source,designed and build by CEA Grenoble,was installed and commissioned at CERN in 2005.Since than the source has delivered oxygen and lead ion beams (O4+ and Pb27+ from the source,Pb54+ from the linac)for the commissioning of the Low Energy Ion Ring(LEIR).Results of this operation and attempts to improve the source performance and reliability,and the linac performance will be presented in this paper.

  4. [Apprenticeship in radiology at the University Hospital Center in Grenoble: research on the most effective methods].

    Science.gov (United States)

    Roland, S; Charlin, B; Ferretti, G; Bergeron, D; Coulomb, M

    1999-05-01

    From analyses of strengths and weaknesses of the apprenticeship of radiology in France, of existing pedagogic methods, of time constraints within clinical settings and of scientific theories of teaching and learning, the authors define objectives that teaching should target and propose a new method of instruction problem and practise-based. The method appears applicable in French radiology departments. It should forster early acquisition by residents of professional attitudes and way of thinking, and make them active self-directed learners.

  5. [Ethics consultation unit in nephrology (UCEN): review of 10 years of operation in the Grenoble area].

    Science.gov (United States)

    Maurizi Balzan, Jocelyne; Moreaud, Olivier; Palacin, Pedro; Truche, Anne-Sophie; Zaoui, Philippe

    2013-07-01

    The existence of an ethics consultation unit in nephrology (UCEN) gives to the nephrologist the collegiality required to meet the difficulties of therapeutic choice on a legislative level, particularly in indications of stop dialysis. The discussion conducted, outside the emergency, is guided by a tool for reflexion that details successive steps necessary to the identification of elements required for decision-making. Thanks to complementary skills provided by the participants and training acquired, the UCEN can approach other ethic issues encountered during practice such as contrindication for a kidney transplantation or maintenance of conservative treatment, or performing invasive procedures on patients refusing transfusion. Propositions are not always relevant due to opposition or ambivalence of some patients, their relatives, an external or disagreements between teams or a mismatch between the technical and the patient's condition. These non-conformities decrypted always have an explanation, sometimes they are understood and accepted by the teams, and sometimes they became source of regrets when they extend life in very poor conditions. The UCEN, if it does not solve every single point, remains a place and a time of sharing that face difficult situations, help the nephrologist positioning himself on maintaining treatments that were first to avoid and prevent the realization of unreasonable acts and accept their limits.

  6. [Bacterial contamination of multi-dose ocular solutions. A prospective study at the Grenoble Teaching Hospital].

    Science.gov (United States)

    Brudieu, E; Duc, D L; Masella, J J; Croize, J; Valence, B; Meylan, I; Mouillon, M; Franco, A; Calop, J

    1999-12-01

    The bacterial contamination rate of multidose ocular solutions used by hospitalized patients was evaluated by culturing vial dropper tips and residual solution in vials. Bacterial colonies were counted and identified. Overall 39 (23.5%) selected vials were contaminated. Contamination rates were 17.7% (20/113) for vials used by ophthalmology ward patients and 35.8% (19/53) for vials used by internal medicine and gerontology patients (P < 0.02). The most commonly identified organisms were part of the normal commensal flora. Three ophthalmology patients were using vials contaminated with Pseudomonas aeruginosa. A significant (P < 0.01) positive correlation was found between vial contamination rate and duration of vial use. Vials containing an antimicrobial agent were less likely to be contaminated than vials without antimicrobials (P < 0.01). No clinical consequences of vial contamination were identified. However, ocular solution vial contamination carries a risk of infection. Our data are evidence of inadequate efficacy of preservatives present in ocular solutions. The standard practice of using ocular solution vials for seven days in health care facilities may need to be reappraised. Care should be taken to ensure that health care providers and patients understand the rules for ocular solution use. Unit-dose presentations may be preferable over multi-dose presentations for in hospital treatment.

  7. [Ragweed in France and the Rhône-Alpes region (Lyon, Bourgoin, Grenoble, Roussillon].

    Science.gov (United States)

    Thibaudon, M; Lachasse, C; Finet, F

    2003-03-01

    Ragweed in France is a rather recent pollen which causes strong allergies on the populations concerned. This pollen, mainly located in the area Rhone-Alpes, extend more and more on totality of France. Indeed, the pollinic data highlight the presence of ragweed on all the territory with very low, as for Brittany, to several hundreds grains in the area of Rhone-Alpes. So four towns of this area have followed closely the extend of this pollen during the year 2002 through five pollen-traps (2 for the town of Lyon). The trap of Lyon I (Gerland) made it possible to follow temporal the extend of ragweed from 1987 to 2002 and the increase of the number of grains as that of the number of days with a significant allergic risk. The study shows also the differences in quantity of pollens, the differences between the daily allergic risks of the five sites, as well as the differences, between the cities, of the number of days when the allergic risk is significant. It is necessary that pollen of ragweed can be followed closely because of its strong allergenic capacity, in the area of Rhone-Alpes, where the plant prevails mainly, but also on the totality of the own territory, this to supervise its evolution and the speed of proliferation of the plant.

  8. Estadio olímpico para deportes de hielo, en Grenoble, Francia

    Directory of Open Access Journals (Sweden)

    Esquillan, N.

    1969-09-01

    Full Text Available This article describes mainly the structural aspects of the stadium, including the foundations, and the large roof. Construction and finishing details are also given.En este artículo se describen, principalmente, las partes de la estructura del Estadio, atendiendo a los cimientos y, principalmente, al conjunto de la gran cubierta y a sus detalles de construcción y ejecución.

  9. Value of combined detection of serum SCC, CEA, NSE and CYFRA21-1 in the diagnosis of esophageal cancer%血清鳞状上皮细胞癌相关抗原、癌胚抗原、神经元特异性烯醇化酶及细胞角蛋白19片段抗原检测在食管癌诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    曹红; 江华

    2013-01-01

    Objective To explore the diagnostic value of serum tumor marker SCC, CEA, NSE and CYFRA21-1 detection in early diagnosis of esophageal cancer, and to provide theoretical reference for diagnosis and treatment of esophageal cancer.Methods Serum levels of SCC, CEA, NSE, CYFRA21-1 were detected by full automatic chemilu-minescence immune assay in 86 patients with esophageal cancer (the esophageal cancer group) and 100 healthy controls (the control group).Results ①Serum levels of SCC, CEA, SCE, CYFRA21-1 in esophageal patients were significantly higher than those of in control group (P < 0.05), and when the clinical stage and depth of tumor invasion increased, the level of serum tumor marker was significantly increased (P < 0.05 or P < 0.01).②The positive detection rate of SCC, CEA, NSE and CYFRA21-1 in esophageal cancer group was 26.7%, 36.0%, 24.4%, 53.5%.The four kinds of tumor markers joint detection in early diagnosis of esophageal cancer had higher sensitivity and specificity the sensitivity and specificity were 82.6% and 83.7%.Conclusion Measurement of serum SCC, CEA, SCE and Cyfra21 -1 is helpful in the diagnosis of esophageal, and multiple tumor markers joint detection can improve the sensitivity of clinical diagnosis.%目的 探讨血清肿瘤标志物鳞状上皮细胞癌相关抗原(SCC)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)及细胞角蛋白19片段抗原(CYFRA21-1)在食管癌早期诊断中的应用价值,旨在为食管癌的诊治提供理论参考.方法 应用全自动化学免疫分析检测86例食管癌患者(食管癌组)和100例健康体检者(对照组)血清SCC、CEA、NSE、CYFRA21-1的表达.结果 ①SCC、CEA、NSE、CYFRA21-1在食管癌患者中的含量均明显高于健康人(P < 0.05),并随着临床分期、肿瘤浸润深度的增加而显著增加(P < 0.05或P < 0.01).②食管癌组SCC、CEA、NSE、CYFRA21-1阳性检测率分别为26.7%、36.0%、24.4%、53.5%,敏感性较低;多项血清肿瘤标

  10. Efeito do ácido indolbutírico e épocas de estaqueamento sobre o enraizamento de estacas herbáceas de figueira (Ficus carica L. = Effect of indolbutiric acid and times of cutting on rooting of herbaceous cuttings of fig (Ficus carica L.

    Directory of Open Access Journals (Sweden)

    Luciane Arantes de Paula

    2009-01-01

    Full Text Available Este trabalho teve como objetivo verificar o efeito de seis concentrações de ácido indolbutírico (IBA no enraizamento de estacas herbáceas de figueira (Ficus carica L. sob nebulizaçãointermitente, em três épocas diferentes. Os ensaios foram instalados em maio/2004, setembro/2004 e janeiro/2005, e, em cada época, o delineamento experimental utilizado foi o inteiramentecasualizado, com seis concentrações de IBA (0, 500, 1.000, 1.500, 2.000, 2.500 e 3.000 mg L-1. As estacas foram coletadas na Fazenda de Ensino, Pesquisa e Extensão da Unesp, localizada nomunicípio de Selvíria, Estado de Mato Grosso do Sul, sendo padronizadas com 10 cm de comprimento e duas folhas. Após o preparo das estacas, estas foram tratadas com solução de Metiltiofan, posteriormente imersas nas soluções de IBA por 10 min. Em seguida, realizou-se o plantio em jardineiras plásticas de cor preta, contendo vermiculita, que foram transportadas para telado, com 50% de redução de luz, com sistema de irrigação do tipo nebulização intermitente. Asvariáveis analisadas foram: porcentagem de estacas sobreviventes e enraizadas, número de raízes, comprimento máximo do sistema radicular e massa da matéria seca da raiz. Nas condições em que o trabalho foi conduzido, permite-se concluir que: é viável a propagação herbácea de figueira; houve efeito do IBA apenas em maio, em que a melhor dose foi de 1.000 mg L-1; as melhores épocas para estaquia de estacas herbáceas de figueira são em setembro e janeiro, sem utilização de IBA, nas quais foram obtidos melhores resultados quanto à porcentagem de estacas enraizadas.This work had as objective to verify the effect of six concentrationsof indolbutiric acid (IBA in the rooting of herbaceous cuttings of fig (Ficus carica L. under intermittent mist irrigation, at three different times. The assays were installed in May, Septemberand January, where in each time the used experimental design was entirely randomized

  11. Values of CEA, CYFRA21-1, NSE and SCC-Ag in pleural effusion and serum in diagnosis of lung cancer%胸水和血清CEA、CYFRA21-1、NSE、SCC-Ag测定对肺癌的诊断价值

    Institute of Scientific and Technical Information of China (English)

    杨铮雯; 邵润霞

    2015-01-01

    目的:探讨胸水和血清中肿瘤标志物癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌抗原(SCC-Ag)联合检测在肺癌中的诊断价值。方法:回顾性分析临床已确诊的101例患者胸水及血清中四项肿瘤标志物水平,应用ROC曲线建立合理的临床诊断临界值,比较各肿瘤标志物在不同病理类型肺癌表达情况。结果:肺癌组胸水和血清中四项肿瘤标志物水平均高于良性组(P <0.05),CEA对肺腺癌、NSE对小细胞肺癌、CYFRA21-1和SCC-Ag对肺鳞癌在胸水和血清中表达水平和阳性率高于其他单项检测(P <0.05);胸水和血清联合检测可提高肺癌检出率。结论:胸水和血清肿瘤标志物联合检测对肺癌检出及病理分型具有重要的参考价值。%Objective To investigate the values of combined determination of pleural effusion and serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), neuron-specific enolase (NSE), and squamous cell carcinoma antigen (SCC-Ag) in diagnosis of lung cancer. Methods 101 patients with pleural effusion were reviewed retrospectively. Expressions of CEA, CYFRA21-1, NSE and SCC-Ag in pleural fluid and serum were detected; the optimum cut-off points resulting from the best sensitivity-specificity balance in the receiver operator characteristic (ROC) curves were constructed. The expressions of the tumor markers were compared among different pathological types of lung cancer. Results The levels of tumor markers in both pleural effusion and serum were significantly higher in patients with lung cancer than the benign group (P < 0.05). The expression levels and positive rate of CEA for lung adenocarcinoma, NSE for small cell lung cancer, and CYFRA21-1and SCC-Ag for pulmonary squamous cell carcinoma were higher than any other single detection (P < 0.05). Combined detection of the tumor markers in pleural

  12. 非小细胞肺癌患者呼出气冷凝液中CEA检测的临床意义%Clinical significance of measuring the CEA in exhaled breath condensate of patients with non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    董敬军; 陶一江; 陈建荣; 蔡映云; 陶国华

    2008-01-01

    目的 研究非小细胞肺癌(NSCLC)患者呼出气冷凝液(EBC)中癌胚抗原(CEA)检测的临床意义.方法 采用德国JAEGER公司的EBC收集器,收集NSCLC组和正常对照组的EBC,所有对象同时抽血留血清待测.采用非平衡放射免疫分析法(RIA)测定EBC和血清中CEA.结果 ①肺癌组CEA检测值,EBC为4.52±2.44 mg/L,血清为7.73±3.19 mg/L;正常对照组CEA检测值,EBC为1.62±1.30 mg/L,血清为2.28.±1.30 mg/L,两组比较有显著统计学意义(P<0.01);②腺癌组EBC和血清标本中CEA水平分别为(4.91±2.56 mg/L)和(9.17±3.75mg/L),高于正常对照组(P<0.05);③Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期NSCLC患者EBC中CEA水平分别为3.32±1.58mg/L、4.11±2.45mg/L、4.75±2.50 mg/L、5.48±2.41mg/L,TNM分期越高,EBC中CEA的水平越高,F=3.12,P<0.05;④肺癌组EBC和血清CEA检测值呈线性正相关,回归方程=1.61x-1.51,相关系数(r)=0,8615,P<0.05;⑤肺癌组EBC中CEA检测的敏感性和特异性为51.5%和93.3%,血清中为60.6%和91.1%.肺癌组同时进行EBC和血清中CEA检测,联合敏感性为80.9%,联合特异性85.0%.结论 在EBC中检测CEA水平有助于肺癌的早期诊断和临床分期的判断.

  13. La medición y vigilancias de la enfermedad de la mancha foliar producida por la sigatoka negra (Mycospharella fijiensis var diformis Morelet en la producción de musáceas: un enfoque para lograr la sostenibilidad del desarrollo

    Directory of Open Access Journals (Sweden)

    Edgardo Vargas Jarquín

    2013-05-01

    Full Text Available En el presente trabajo se discute la necesidad de utilizar tecnología, como el procesamiento digital de imágenes para mejorar los procesos de medición y vigilancia de la enfermedad de la mancha de la hoja causada por SIGATOKA NEGRA (Mycospharella fijiensis var diformis Morelet, pero partiendo de un análisis epistemológico que fundamenta al desarrollo sostenible, que es el marco dentro del cual se encuentra sentido a la aplicación de esta tecnología. Así se define que es la gobernabilidad benéfica del ambiente lo que dirige la gestión de los diferentes actores y esta se da en virtud de comprender, mantener, proteger y administrar la complejidad ambiental.  Se señala como uno de los principales inconvenientes de la producción de musáceas la enfermedad de la sigatoka negra, pues produce costos de producción de aproximadamente 1.300 dólares al año costo en uso y aplicación de pesticidas.  Se discute sobre el enfoque de los trabajos de investigación para el desarrollo sostenible en el cultivo de las musáceas.  Se presentan dos experiencias para medir y vigilar la sigatoka negra. En un caso se desarrolla un sistema convencional denominado SiMu, que permite utilizar medios computacionales asistidos para, sobre todo, medir y vigilar la incidencia de la sigatoka. En el otro caso se utiliza tecnología de procesamiento digital de imágenes para realizar ese mismo trabajo pero con un mayor nivel de automatización.  Queda planteada la interrogante de si esta tecnología se puede usar para pequeños y medianos productores, tanto de banano como de plátano, puesto que en ese tipo de unidades no se podría tener una forma económicamente viable para obtener imágenes digitales aéreas.

  14. Historia natural cuantitativa de una relación parásito-hospedero: el sistema Tristerix-cactáceas en Chile semiárido Quantitative natural history of a host-parasite relationship: the Tristerix-cactus system in semiarid Chile

    Directory of Open Access Journals (Sweden)

    RODRIGO MEDEL

    2002-03-01

    Full Text Available Presentamos información cuantitativa de la historia natural de la relación parásito-hospedero constituida por el muérdago holoparásito Tristerix aphyllus (Loranthaceae y sus hospederos cactáceas. Más específicamente, indagamos en los determinantes históricos y biogeográficos de la interacción y cuantificamos la autoecología de la biología floral, polinización, dispersión y parasitismo en este sistema. El impacto del parasitismo sobre la evolución de sistemas defensivos en las cactáceas hospederas es considerado tanto a nivel intraespecífico como interespecífico, tomando en cuenta el potencial para selección mediada por parásitos y la estructura geográfica de la interacción. Finalmente, sugerimos futuras avenidas de investigación en este sistema que incluyen los tópicos de: (i evolución de la virulencia, (ii estructuración de la interacción en mosaico geográfico y, (iii pruebas históricas de adaptación. Estos aspectos permitirán adquirir un mayor conocimiento de la sutileza ecológica y de la evolución de esta especial interacción en los sistemas naturales de Chile semiáridoWe present quantitative information on the natural history of a host-parasite interaction that consists on the holoparasitic mistletoe Tristerix aphyllus (Loranthaceae and its cacti host species. More specifically, we inquire into the historical and biogeographical setting of the relationship, and quantify the autoecology of the floral biology, pollination, seed dispersal, and parasitism of the system. The impact of the mistletoe on the evolution of defense systems is evaluated both at intraspecific and interspecific levels through consideration of the potential for parasite-mediated selection and the geographical structure of the host-parasite interaction. Finally, we suggest prospective lines of research which include aspects related to: (i the evolution of virulence, (ii the geographic structure of the interaction, and (iii the historical

  15. Enraizamento de estacas herbáceas de quatro clones de umezeiro (Prunus mume Sieb. et Zucc. durante o inverno ameno, em Jaboticabal-SP Rooting of herbaceous cuttings of four mume clones (Prunus mume Sieb. et Zucc. during soft winter, in Jaboticabal, São Paulo state, Brazil

    Directory of Open Access Journals (Sweden)

    Newton Alex Mayer

    2003-12-01

    Full Text Available Estudos realizados no Brasil com o umezeiro (Prunus mume Sieb. et Zucc. relatam promissoras perspectivas de utilização desta espécie como porta-enxerto para pessegueiro e nectarineira, em função de sua rusticidade, adaptação ao inverno brando, compatibilidade com Prunus persica, redução do vigor das plantas e melhoria da qualidade dos frutos. Entretanto, em função da propagação por sementes, tem sido observadas diferenças de vigor entre as plantas, resultando em pomares muito heterogêneos. Assim, o presente estudo teve por objetivo estudar o enraizamento de estacas herbáceas de quatro clones de umezeiro (Clones 02, 05, 10 e 15 durante o inverno ameno, em Jaboticabal-SP. O experimento foi conduzido entre os meses de junho e agosto, sendo avaliado aos 70 dias após a estaquia. Pelos resultados obtidos, foi possível concluir que é viável a propagação dos clones estudados por enraizamento de estacas herbáceas durante o inverno. Foram observadas diferenças entre os clones quanto à porcentagem de enraizamento, porcentagem de estacas com calo, número e comprimento das raízes. No conjunto das variáveis analisadas, os melhores resultados foram obtidos com os Clones 10 e 15.Studies developed in Brazil with the mume (Prunus mume Sieb. et Zucc. have shown promising perspectives of using this species as rootstock for peach and nectarine trees, in function of its rusticity, adaptation to soft winter, compatibility with Prunus persica, plant vigor reduction and improvement of the fruit quality. However, due to seed propagation, vigor differences have been observed among plants, resulting in very heterogeneous orchards. Thus, the present study had the objective of studying the rooting of herbaceous cuttings of four mume clones (Clones 02, 05, 10 and 15 in intermittent mist during the soft winter, in Jaboticabal, São Paulo State, Brazil. The experiment was carried out between June and August, being evaluated 70 days after the cutting

  16. 99mTc-MDP 全身骨扫描和血清 CEA、NSE、CYFR21-1、CA125 测定对小细胞肺癌骨转移的临床评价%Clinical evaluation of 99mTc-MDP bone scintigraphy and serum CEA, NSE,CYFRA21-1 and CA125 in skeletal metastasis of the small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    张炜; 郭万华

    2015-01-01

    目的:分析99m Tc-MDP全身骨扫描小细胞肺癌骨转移病灶分布特点及血清肿瘤标志物CEA、NSE、CYFRA21-1、CA125与小细胞肺癌骨转移发生的相关性. 方法:回顾性分析56例经病理证实的小细胞肺癌患者 99m Tc-MDP全身骨扫描影像表现及血清肿瘤标志物水平,用ROC曲线及Spearman相关分析评价肿瘤标志物水平对肺癌骨转移发生及发展的诊断意义. 结果:21 例骨转移阳性病灶中胸部占46.60%,脊柱34.95%,骨盆9.71%,四肢5.83%,头颅2.91%. 骨转移阳性组CEA、NSE 质量浓度高于骨转移阴性组(均P<0.05),曲线下面积(AUC)分别为0.789、0.717,且CEA、NSE质量浓度与骨转移分级呈正相关(r值分别为0.540、0.417). 结论:小细胞肺癌以胸部及脊柱等中轴骨多发性骨转移为主,CEA、NSE血清水平随着骨转移病灶数的增加有显著上升趋势,对判定小细胞肺癌骨转移的发生及发展有一定的参考意义.%Objective:To analyze the distribution characteristic of the skeletal metastasis lesion in 99mTc-MDP bone scintigraphy and the correlation between serum tumor marker (CEA,NSE, CYFRA21-1 and CA125) and skeletal metastasis in small cell lung cancer .Methods:56 cases with small cell lung confirmed by pathology were examined with 99m Tc-MDP bone scintigraphy .Serum concentration of CEA , NSE, CYFRA21-1 and CA125 were measured one week before whole-body bone scanning .ROC curve and spearman correlation analysis were used to evaluate the serum tumor markers in diagnose the development of the skeletal metastasis .Results: 21 imaging positive lesions were identified as the skeletal metastasis .The distribution of the skeletal metastasis lesions were:chest(46.60%), spine(34.95%), pelvis(9.71%), four limbs(5.83%), skull(2.91%).CEA,NSE levels in bone metastasis group were significant higher than those in the negative group ( P<0.05 ) and the area of ROC curve were 0.789 and 0.717 respectively(P<0.05).There was a correlation between

  17. Efecto de la densidad de semillas en la germinación de Isolatocereus dumortieri y Myrtillocactus geometrizans, cactáceas columnares endémicas de México Effect of seed density on germination of Isolatocereus dumortieri and Myrtillocactus geometrizans, endemic columnar cacti species from Mexico

    Directory of Open Access Journals (Sweden)

    Joel Flores

    2009-04-01

    Full Text Available Se evaluó el efecto de la densidad de semillas en la germinación de 2 cactáceas columnares: Isolatocereus dumortieri y Myrtillocactus geometrizans. Se utilizaron 5 tratamientos de densidad de semillas (1, 5, 10, 20 y 50 semillas. Isolatocereus dumortieri mostró menor porcentaje de germinación con el aumento de la densidad, mientras que la germinación de M. geometrizans no fue afectada por la densidad de semillas. Estos resultados sugieren que las plántulas de I. dumortieri podrían competir por recursos.The effect of seed density on the germination of 2 columnar cactus species (Isolatocereus dumortieri and Myrtillocactus geometrizans was evaluated using 5 seed density treatments (1, 5, 10, 20 and 50 seeds. Isolatocereus dumortieri had a lower germination percentage with increasing seed density; germination of M. geometrizans was not affected by seed density. These results suggest that I. dumortieri seedlings might compete for resources with siblings.

  18. Pegamento e crescimento inicial de enxertos do pessegueiro 'Aurora-1' em clones de umezeiro (Prunus mume Sieb. et Zucc. e 'Okinawa' [Prunus persica (L. Batsch] propagados por estacas herbáceas Tissue union and initial growth of 'Aurora-1' peach buds on mume clones (Prunus mume Sieb. et Zucc. and 'Okinawa' [Prunus persica (L. Batsch] propagated by herbaceous cuttings

    Directory of Open Access Journals (Sweden)

    Newton Alex Mayer

    2005-04-01

    Full Text Available O presente estudo teve por objetivo avaliar o pegamento e o crescimento inicial de enxertos do pessegueiro 'Aurora-1' em clones de umezeiro (Prunus mume Sieb. et Zucc. e 'Okinawa' [Prunus persica (L. Batsch] propagados por estacas herbáceas. Realizaram-se dois experimentos, adotando-se a enxertia de borbulhia por escudo (março e borbulhia por escudo modificada (julho. Com os resultados obtidos, pode-se concluir que é viável a realização da enxertia do 'Aurora-1' nos Clones 05; 10 e 15 de umezeiro e no 'Okinawa', tanto em março quanto em julho, com as metodologias utilizadas. O 'Okinawa' induz crescimento mais rápido ao enxerto, de forma que o ponto máximo do comprimento é atingido em tempo menor.This study aimed to evaluate the tissue union and initial growth of 'Aurora-1' peach buds on mume clones (Prunus mume Sieb. et Zucc. and 'Okinawa' [Prunus persica (L. Batsch] propagated by herbaceous cuttings. Two experiments were carried out, being adopted the chip budding (March and chip budding modified (July. The results showed that accomplishment of 'Aurora-1' peach bud on mume Clones 05, 10 and 15 and 'Okinawa' is viable, in both periods, with the methodologies used. The 'Okinawa' induces faster growth to the bud and the maximum length point is reached in a short time.

  19. The Comparison Analysis of the Albumin LDH,CEA in Pleural Effusion and Serum with Tuberculous Pleuritis%结核性胸膜炎胸液与血清的蛋白、LDH、CEA的含量对比分析

    Institute of Scientific and Technical Information of China (English)

    王枫

    2003-01-01

    目的:探讨结核性胸膜炎确诊的可靠率,精选确切的诊断指标.方法:对32例结核性胸膜炎患者通过首次胸液的蛋白、LDH、CEA及血清的蛋白、LDH、CEA的含量进行对比分析.结果:胸液与血清蛋白、LDH、CEA平均数比值分别为0.70(>0.5)、3.30(>0.6),0.75(血清中CEA高于胸液).胸液蛋白32例均>30(g/L);LDH 31例>200(u/L);均CEA14-0.1(μg/L)<15.结论:上述三项指标对于结核性胸膜炎的诊断有价值.

  20. Pré-tratamento com água e doses de ácido indolbutírico para estaquia herbácea de pitangueiras Pre-treatments with water and indole butyric acid dosis for herbaceous cuttings of Surinam cherry

    Directory of Open Access Journals (Sweden)

    Daiane Silva Lattuada

    2011-12-01

    Full Text Available No Brasil, a maioria dos pomares de pitangueira (Eugenia uniflora é formada por mudas do tipo pé-franco, o que torna os plantios com baixa uniformidade genética. A propagação vegetativa via estaquia é uma alternativa viável para propagação de diversas espécies frutíferas, podendo ser utilizada também com as espécies nativas, proporcionando a formação de pomares homogêneos, com a produção de mudas com alta sanidade, além de antecipar a produção. Nesse contexto, conduziu-se um estudo visando à multiplicação vegetativa da pitangueira, em que se testou a estaquia herbácea a partir de estacas coletadas de plantas matrizes jovens e adultas, submetidas a três períodos de imersão em água (0, 24 ou 48 horas, além da aplicação de doses de ácido indolbutírico (0, 2000, 4000 e 6000mg L-1. Foram avaliadas a sobrevivência (%, a retenção e a emissão foliar (n° folhas/ estaca, a calogênese (% e enraizamento das estacas (%. Ao final do experimento, avaliou-se massa fresca e seca de parte aérea e raiz, número de folhas e área foliar. O delineamento experimental foi o completamente casualizado, com três repetições de dez plantas por tratamento para os parâmetros não destrutivos e três repetições de cinco plantas por tratamento para os parâmetros destrutivos. A estaquia herbácea foi eficiente para produzir mudas de pitangueira, especialmente quando utilizadas estacas oriundas de plantas jovens sem necessidade de pré-lavagem nem adição de auxinas exógenas.In Brazil, most of the Surinam cherry (Eugenia uniflora orchards is formed by ungrafted plants, which makes the plantations have low genetic uniformity. The vegetative minicutting propagation is a viable alternative for the propagation of several fruit species, and can also be used with native species providing the formation of orchards with homogeneous populations of plants, with production of seedlings with high health and accelerated propagation process

  1. Structure and composition of the ground-herb community in a terra-firme Central Amazonian forest Estrutura e composição da comunidade herbácea terrestre em uma floresta de terra-firme da Amazônia Central

    Directory of Open Access Journals (Sweden)

    Flávia Regina Capellotto Costa

    2004-01-01

    Full Text Available The herb community of tropical forests is very little known, with few studies addressing its structure quantitatively. Even with this scarce body of information, it is clear that the ground herbs are a rich group, comprising 14 to 40% of the species found in total species counts in tropical forests. The present study had the objective of increasing the knowledge about the structure and composition of the ground-herb community and to compare the sites for which there are similar studies. The study was conducted in a tropical non-inundated and evergreen forest 90 km north of Manaus, AM. Ground herbs were surveyed in 22 transects of 40 m², distributed in five plots of 4 ha. The inventoried community was composed of 35 species, distributed in 24 genera and 18 families. Angiosperms were represented by 8 families and Pteridophytes by 10 families. Marantaceae (12 sp and Cyperaceae (4 sp were the richest families. Marantaceae and Poaceae were the families with greatest abundance and cover. Marantaceae, Poaceae, Heliconiaceae and Pteridophytes summed 96% of total herb cover, and therefore were responsible for almost all the cover of the community. The 10 most important species had 83.7% of the individuals. In general, the most abundant species were also the most frequent. Richness per transect varied from 7 to 19 species, and abundance varied from 30 to 114 individuals. The community structure was quite similar to 3 other sites in South America and one site in Asia.A comunidade herbácea das florestas tropicais é pouco conhecida, havendo poucos estudos quantitativos de sua estrutura. Mesmo com esta quantidade escassa de informações, é possível afirmar que as ervas terrestres são um grupo rico, representando 14 a 40% das espécies encontradas em contagens totais de espécies em florestas tropicais. O presente estudo teve como objetivo aumentar o conhecimento sobre a estrutura e composição da comunidade de ervas terrestres e comparar as

  2. Polissacarídeos sulfatados isolados das clorofíceas Caulerpa racemosa e Caulerpa cupressoides – extração, fracionamento e atividade anticoagulante =Sulfated polysaccharides isolated from Caulerpa racemosa and Caulerpa cupressoides (Chlorophyceaes – extraction, fractionation and anticoagulant activity

    Directory of Open Access Journals (Sweden)

    José Ariévilo Gurgel Rodrigues

    2010-04-01

    Full Text Available A incidência de doenças cardiovasculares e os efeitos adversos da heparinoterapia têm motivado a busca por novos agentes terapêuticos e os polissacarídeos sulfatados (PS de algas marinhas têm sido reportados como fontes alternativas para tal. Objetivou-se avaliar o potencial anticoagulante dos PS totais (PST isolados e fracionados das clorofíceas Caulerpa racemosa e Caulerpa cupressoides. Inicialmente, os PST foram extraídos com papaína em tampão acetato desódio 0,1 M (pH 5,0 contendo cisteína 5 mM e EDTA 5 mM, seguidos de fracionamento em coluna de troca iônica de DEAE-celulose com gradiente de NaCl. As frações obtidas foram analisadas por eletroforese em gel de agarose a 0,5% e a atividade anticoagulante, mensurada pelo tempo de tromboplastina parcial ativada (TTPA, usando-se plasma humano normal e comparada a uma curva-padrão de heparina (193 UI mg-1. Verificaram-se semelhantes perfiscromatográficos entre os PS de ambas as espécies, porém com padrões de mobilidades distintas quando as frações foram comparadas por eletroforese. Os PS modificaram o TTPA, cujas atividades anticoagulantes foram de apenas 21,23 e 24,36 UI mg-1, quando eluídos com 0,75 M de sal para C. racemosa e C. cupressoides, respectivamente. Portanto, PS anticoagulantes isolados dasclorofíceas C. racemosa e C. cupressoides resultaram em efeitos anticoagulantes inferiores aos da heparina. Estudos comparativos dessas moléculas também são sugeridos como ferramentas auxiliares na identificação de algas do mesmo gênero.The incidence of cardiovascular diseases and adverse effects from heparintherapy have led to a search for new therapeutic agents, and the sulfated polysaccharides (SP of seaweeds have been reported as alternative sources. The aim of this work was to evaluate the anticoagulant potential of total SP (TSP isolated and fractionated from Caulerpa racemosa and Caulerpa cupressoides (Chlorophyceaes. Initially, the TSP were extracted with papain

  3. Efeito do comprimento de estacas herbáceas de dois clones de umezeiro (Prunus mume Sieb & Zucc. no enraizamento adventício Effect of the length of herbaceous cuttings of two clones of japanese apricot (Prunus mume Sieb & Zucc. in adventicious rooting

    Directory of Open Access Journals (Sweden)

    NEWTON ALEX MAYER

    2002-08-01

    Full Text Available O umezeiro (Prunus mumeSieb & Zucc. é uma rosácea de folhas caducas, nativa da China, cujos frutos e flores são muito apreciados pelos povos orientais. No Brasil, alguns estudos foram realizados visando a sua utilização como porta-enxerto para pessegueiro e nectarineira, dadas as suas características de adaptação, rusticidade, redução do porte da planta e compatibilidade com algumas cultivares de Prunus persica. O presente estudo foi conduzido em câmara de nebulização sob ripado, pertencente ao Departamento de Produção Vegetal da FCAV/UNESP, Câmpus de Jaboticabal-SP. Objetivou-se verificar a influência de quatro comprimentos de estacas herbáceas no enraizamento de dois clones de umezeiro. O material vegetal, identificado como Clone 10 e Clone 15, foi oriundo do Programa de Melhoramento Genético do Instituto Agronômico de Campinas-SP. O experimento foi constituido de fatorial 2 x 4, em blocos casualizados, sendo o fator clone em 2 níveis (Clone 10 e Clone 15 e o fator comprimento de estaca em 4 níveis (12; 15; 18 e 25cm. Pelos resultados observados, verificou-se diferença entre os clones somente na porcentagem de estacas brotadas e número de raízes por estaca. O comprimento da estaca influenciou na porcentagem de enraizamento e na mortalidade das estacas, sendo que estacas maiores tenderam a apresentar maiores porcentagens de enraizamento e menores de mortalidade. As estacas com 12cm, embora apresentando menor número de raízes por estaca, são recomendadas por permitirem a obtenção de um maior número de estacas por planta-matriz. Houve efeito significativo da interação entre os fatores para número e comprimento de raízes.The japanese apricot (Prunus mume Sieb & Zucc. is a Rosaceae of falling leaves, native of China, whose fruits and flowers are quite appreciated by the oriental people. In Brazil, some studies were accomplished seeking its use as rootstock for peach and nectarine trees, due its adaptation

  4. Enraizamento de estacas herbáceas do abacateiro ‘Fuerte’ com diferentes períodos de imersão em solução de ácido indolbutírico = Rooting of herbaceous cuttings of ‘Fuerte’ avocado in solution of indol-butiric acid with different times of immersion

    Directory of Open Access Journals (Sweden)

    Ubirajara Ribeiro Mindêllo Neto

    2007-07-01

    Full Text Available Este trabalho foi realizado na Embrapa, Canoinhas, Estado de Santa Catarina, com o objetivo de verificar o efeito de diferentes tempos de imersão em solução de ácido indolbutírico (AIB no enraizamento de estacas herbáceas do abacateiro ‘Fuerte’. As estacas foram coletadas em 25/5/04 de plantas com um ano de idade e preparadas com diâmetroentre 4 a 6 mm e 10 cm de comprimento, permanecendo no terço superior duas folhas cortadas ao meio. Os tratamentos foram os seguintes: 5 e 30 segundos; 5 minutos; 1, 4, 8 e 12 horas em solução de 1000 mg L-1 de AIB. O delineamento experimental foi inteiramente casualizado, com sete tratamentos, quatro repetições e doze estacas por parcela. Após aaplicação do AIB, as estacas foram colocadas em bandejas de poliestireno expandido com 72 células, contendo turfa como substrato e levadas para enraizar em casa-de-vegetação com nebulização intermitente. Após 185 dias, foi realizada a avaliação do experimento. Os períodos de imersão rápida, por 5 e 30 segundos na solução de 1000 mg L-1 de AIB apresentaram-se mais favoráveis ao enraizamento das estacas, sendo superiores estatisticamente aos demais tempos de imersão. Os tempos de imersão superiores a uma hora apresentaram efeito fitotóxico. Recomenda-se para a estaquia herbácea de plantas juvenis do abacateiro ‘Fuerte’ a imersão por 30 segundos em solução de 1000 mg L-1 de AIB.This study was carried out at Embrapa, Canoinhas, state of Santa Catarina, Brazil, aiming to verify the effect of different times of immersion in solution of indol-butiric acid (IBA in the rooting of herbaceous cuttings of ‘Fuerte’ avocado. The cuttings were collected on May 25th, 2004, from one-yearold plants and prepared with a 4-6mm diameter and 10cm long, with 2 remaining leaves cut in the middle, in the upper third part. The treatments were the following: 5 and 30seconds; 5 minutes; 1, 4, 8 and 12 hours in solution of 1000 mg L-1 of IBA. The

  5. Diatomáceas cêntricas de rios na região de abrangência da usina hidrelétrica de Salto Caxias, PR, (Bacia do rio Iguaçu Centric diatoms from rivers in the region to be dammed for the construction of the Salto Caxias hydroelectric power plant, Paraná State

    Directory of Open Access Journals (Sweden)

    Nicole M Brassac

    1999-12-01

    Full Text Available Realizou-se o inventário florístico das diatomáceas cêntricas dos rios da região a ser inundada para construção do reservatório da Usina Hidrelétrica de Salto Caxias, localizado a sudoeste do Estado do Paraná. Amostras planctônicas foram coletadas mensalmente, em 15 estações de coleta, no período compreendido entre março/97 e fevereiro/98. Foram identificados 19 táxons infragenéricos. Aulacoseira ambígua var. ambígua f. ambígua, A. granulata var. granulata, A. granulata var. angustíssima e Melosira varians foram registradas em pelo menos 85% das 171 amostras estudadas. Aulacoseira agassizii var. agassizii e Melosira undulata var. normanii são citações pioneiras para o Estado do Paraná, assim como Terpsinoe musica var. musica é registrado pela primeira vez em ambientes continentais paranaenses.The survey is a floristic inventory of centric diatoms from the region to be flooded by the construction of the Salto Caxias hydroelectric power plant reservoir, in southeast Paraná State, Brazil. Planktonic sampling was carried out monthly, from March/97 to February/98. Nineteen infrageneric taxa were identified. Aulacoseira ambígua var. ambígua, A. granulata var. granulata, A. granulata var. angustíssima and Melosira varians being the most common taxa, occuring in 85% of the 171 samples studied. Aulacoseira agassizii var. agassizii and Melosira undulata var. normanii are new records for the State of Paraná, and Terpsinoe musica var. musica registered for the first time in freshwater environments in this state.

  6. 胸水脱落细胞DNA含量及VEGF,p53和CEA表达在良恶性胸腔积液鉴别中的意义%Clinical significance of DNA content and VEGF, p53 and CEA expressions in the differential diagnosis of malignant and benign pleural effusions

    Institute of Scientific and Technical Information of China (English)

    周箴; 陈岗; 宣学金; 张俭

    2007-01-01

    目的:探讨检测胸水细胞的DNA倍体以及VEGF、p53、CEA表达鉴别良恶性胸腔积液的价值.方法:73例胸腔积液患者,良性组13例,恶性组60例.图像细胞光度技术(image cytometry,ICM)进行DNA含量检测,免疫组化Envision法检测VEGF、p53、CEA.结果:良性胸水DNA异倍体率仅占23.1%.恶性胸水的异倍体率占77.8%,两者有统计学差异(P=0.001).良性胸腔积液患者VEGF、p53、CEA表达率分别为12.5%、0、0.恶性胸腔积液VEGF、p53、CEA表达率分别为17.5%,17.5%和68.4%,与良恶性胸腔积液中CEA的表达相比有统计学差异(P<0.001),VEGF和p53的表达无显著差异(P=0.722,P=0.198).经DNA倍体联合VEGF、p53、CEA检测,敏感率可达90.4%,特异度87.5%,符合率90%.结论:ICM检测胸水细胞的DNA倍体联合VEGF、p53、CEA表达值得进一步探讨,有可能成为鉴别良恶性胸腔积液的又一方法.

  7. The relationship between circulating tumor cells counting and Cyfra21 -1,CEA,Fg%循环肿瘤细胞数目与血清中 Cyfra21-1、CEA、Fg 表达水平的关系

    Institute of Scientific and Technical Information of China (English)

    陈可绪; 陈东杰; 李毅斌; 张昱; 汪森明

    2015-01-01

    目的:探讨肿瘤患者外周血循环肿瘤细胞(CTCs)与常用的肿瘤指标细胞角质素19可溶片段(Cy-fra21-1)、癌胚抗原(CEA)及凝血功能指标纤维蛋白原(Fg)表达水平的关系,比较 CTCs 阳性组和阴性组转移灶数目差异。方法:采集66例进展期晚期肺癌住院患者治疗前7.5ml 外周血,保存于4℃冰箱中,24小时内由益善生物技术公司使用“免疫去除结合纳米过滤法”行 CTCs 检测。同时检测血清中 Cyfra21-1、CEA、Fg水平,收集并分析 CTCs 数目与转移灶数目、临床 T 分期、转移淋巴结的关系。结果:纳入患者中 CTCs 检出率为86.4%。CTCs 数目与 Cyfra21-1水平有相关关系,相关系数为0.365(P =0.003);CTCs 数目与 Fg 水平相关,相关系数为0.330(P =0.007);CEA 与 CTCs 两变量无明显相关性。两组患者的肿瘤转移器官数目大于3个的比例有显著差异。结论:两组患者 Cyfra21-1异常增高率有显著差异,且 CTCs 数目与 Cyfra21-1表达水平正相关,可由 Cyfra21-1初步估计 CTCs 水平。而外周血中 Fg 异常增高率无显著差异,但二者表达水平呈明显正相关,因此分析 CTCs 数目需要考虑 Fg 表达水平的影响。%Objective:To investigate the relevance between circulating tumor cells(CTCs)counting and the fol-lowing tumor markers:Cyfra21 -1,CEA,Fg,and compare the survival,sites of metastasis organs among patients strati-fied by CTCs counting.Methods:We selected 66 histologically diagnosed advanced lung cancer patients of progression period,applied CanpotrolTM,which developed by SurExam biotechnology company to detect CTCs in the blood,7. 5ml blood was needed before treatment for CTCs test.All the samples were stored at 4 cent degree after collection,and samples were tested within 24h.Serum concentration of Cyf