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Sample records for cdr review paducah

  1. Review of earthquake hazard assessments of plant sites at Paducah, Kentucky and Portsmouth, Ohio

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    Members of the US Geological Survey staff in Golden, Colorado, have reviewed the submissions of Lawrence Livermore National Laboratory (LLNL) staff and of Risk Engineering, Inc. (REI) (Golden, Colorado) for seismic hazard estimates for Department of Energy facilities at Portsmouth, Ohio, and Paducah, Kentucky. We reviewed the historical seismicity and seismotectonics near the two sites, and general features of the LLNL and EPRI/SOG methodologies used by LLNL and Risk Engineering respectively, and also the separate Risk Engineering methodology used at Paducah. We discussed generic issues that affect the modeling of both sites, and performed alternative calculations to determine sensitivities of seismic hazard results to various assumptions and models in an attempt to assign reasonable bounding values of the hazard. In our studies we find that peak acceleration values of 0.08 g for Portsmouth and 0.32 g for Paducah represent central values of the, ground motions obtained at 1000-year return periods. Peak accelerations obtained in the LLNL and Risk Engineering studies have medians near these values (results obtained using the EPRI/SOG methodology appear low at both sites), and we believe that these medians are appropriate values for use in the evaluation of systems, structures, and components for seismic structural integrity and for the seismic design of new and improved systems, structures, and components at Portsmouth and Paducah.

  2. Review of earthquake hazard assessments of plant sites at Paducah, Kentucky and Portsmouth, Ohio

    International Nuclear Information System (INIS)

    1997-01-01

    Members of the US Geological Survey staff in Golden, Colorado, have reviewed the submissions of Lawrence Livermore National Laboratory (LLNL) staff and of Risk Engineering, Inc. (REI) (Golden, Colorado) for seismic hazard estimates for Department of Energy facilities at Portsmouth, Ohio, and Paducah, Kentucky. We reviewed the historical seismicity and seismotectonics near the two sites, and general features of the LLNL and EPRI/SOG methodologies used by LLNL and Risk Engineering respectively, and also the separate Risk Engineering methodology used at Paducah. We discussed generic issues that affect the modeling of both sites, and performed alternative calculations to determine sensitivities of seismic hazard results to various assumptions and models in an attempt to assign reasonable bounding values of the hazard. In our studies we find that peak acceleration values of 0.08 g for Portsmouth and 0.32 g for Paducah represent central values of the, ground motions obtained at 1000-year return periods. Peak accelerations obtained in the LLNL and Risk Engineering studies have medians near these values (results obtained using the EPRI/SOG methodology appear low at both sites), and we believe that these medians are appropriate values for use in the evaluation of systems, structures, and components for seismic structural integrity and for the seismic design of new and improved systems, structures, and components at Portsmouth and Paducah

  3. Spent nuclear fuel Canister Storage Building CDR Review Committee report

    Energy Technology Data Exchange (ETDEWEB)

    Dana, W.P.

    1995-12-01

    The Canister Storage Building (CSB) is a subproject under the Spent Nuclear Fuels Major System Acquisition. This subproject is necessary to design and construct a facility capable of providing dry storage of repackaged spent fuels received from K Basins. The CSB project completed a Conceptual Design Report (CDR) implementing current project requirements. A Design Review Committee was established to review the CDR. This document is the final report summarizing that review

  4. Optical System Critical Design Review (CDR) Flight Software Summary

    Science.gov (United States)

    Khorrami, Mori

    2006-01-01

    The Mid Infrared Instrument (MIRI FSW presentation covers: (1) Optical System FSW only and Cooling System FSW is covered at its CDR (2) Requirements & Interfaces (3) Relationship with the ISIM FSW (4) FSW Design Drivers & Solutions.

  5. Independent Technical Review of the C-400 Interim Remedial Project Phase I Results, Paducah, Kentucky

    International Nuclear Information System (INIS)

    Looney, B.; Rossabi, J.; Stewart, L.; Richards, W.

    2010-01-01

    The groundwater and soil in the vicinity of the C-400 Building at the Paducah Gaseous Diffusion Plant (PGDP), is contaminated with substantial quantities of industrial solvents, primarily trichoroethene (TCE). This solvent 'source' is recognized as a significant challenge and an important remediation target in the overall environmental cleanup strategy for PGDP. Thus, the cleanup of the C-400 TCE Source is a principal focus for the Department of Energy (DOE) and its contractors, and for PGDP regulators and stakeholders. Using a formal investigation, feasibility study and decision process, Electrical Resistance Heating (ERH) was selected for the treatment of the soil and groundwater in the vicinity of C-400. ERH was selected as an interim action to remove 'a significant portion of the contaminant mass of TCE at the C-400 Cleaning Building area through treatment' with the longer term goal of reducing 'the period the TCE concentration in groundwater remains above its Maximum Contaminant Level (MCL).' ERH is a thermal treatment that enhances the removal of TCE and related solvents from soil and groundwater. The heterogeneous conditions at PGDP, particularly the high permeability regional gravel aquifer (RGA), are challenging to ERH. Thus, a phased approach is being followed to implement this relatively expensive and complex remediation technology. Conceptually, the phased approach encourages safety and efficiency by providing a 'lessons learned' process and allowing appropriate adjustments to be identified and implemented prior to follow-on phase(s) of treatment. More specifically, early deployment targeted portions of the challenging RGA treatment zone with relatively little contamination reducing the risk of adverse collateral impacts from underperformance in terms of heating and capture. Because of the importance and scope of the C-400 TCE source remediation activities, DOE chartered an Independent Technical Review (ITR) in 2007 to assess the C-400 ERH plans prior

  6. INDEPENDENT TECHNICAL REVIEW OF THE C-400 INTERIM REMEDIAL PROJECT PHASE I RESULTS, PADUCAH, KENTUCKY

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Rossabi, J.; Stewart,L.; Richards, W.

    2010-10-29

    The groundwater and soil in the vicinity of the C-400 Building at the Paducah Gaseous Diffusion Plant (PGDP), is contaminated with substantial quantities of industrial solvents, primarily trichoroethene (TCE). This solvent 'source' is recognized as a significant challenge and an important remediation target in the overall environmental cleanup strategy for PGDP. Thus, the cleanup of the C-400 TCE Source is a principal focus for the Department of Energy (DOE) and its contractors, and for PGDP regulators and stakeholders. Using a formal investigation, feasibility study and decision process, Electrical Resistance Heating (ERH) was selected for the treatment of the soil and groundwater in the vicinity of C-400. ERH was selected as an interim action to remove 'a significant portion of the contaminant mass of TCE at the C-400 Cleaning Building area through treatment' with the longer term goal of reducing 'the period the TCE concentration in groundwater remains above its Maximum Contaminant Level (MCL).' ERH is a thermal treatment that enhances the removal of TCE and related solvents from soil and groundwater. The heterogeneous conditions at PGDP, particularly the high permeability regional gravel aquifer (RGA), are challenging to ERH. Thus, a phased approach is being followed to implement this relatively expensive and complex remediation technology. Conceptually, the phased approach encourages safety and efficiency by providing a 'lessons learned' process and allowing appropriate adjustments to be identified and implemented prior to follow-on phase(s) of treatment. More specifically, early deployment targeted portions of the challenging RGA treatment zone with relatively little contamination reducing the risk of adverse collateral impacts from underperformance in terms of heating and capture. Because of the importance and scope of the C-400 TCE source remediation activities, DOE chartered an Independent Technical Review (ITR) in

  7. REVIEW REPORT: BUILDING C-400 THERMAL TREATMENT 90 PERCENT REMEDIAL DESIGN REPORT AND SITE INVESTIGATION, PGDP, PADUCAH, KENTUCKY

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B; Jed Costanza, J; Eva Davis, E; Joe Rossabi, J; Lloyd (Bo) Stewart, L; Hans Stroo, H

    2007-08-15

    On 9 April 2007, the U.S. Department of Energy (DOE) Headquarters, Office of Soil and Groundwater Remediation (EM-22) initiated an Independent Technical Review (ITR) of the 90% Remedial Design Report (RDR) and Site Investigation (RDSI) for thermal treatment of trichloroethylene (TCE) in the soil and groundwater in the vicinity of Building C-400 at the Paducah Gaseous Diffusion Plant (PGDP). The general ITR goals were to assess the technical adequacy of the 90% RDSI and provide recommendations sufficient for DOE to determine if modifications are warranted pertaining to the design, schedule, or cost of implementing the proposed design. The ultimate goal of the effort was to assist the DOE Paducah/Portsmouth Project Office (PPPO) and their contractor team in ''removing'' the TCE source zone located near the C-400 Building. This report provides the ITR findings and recommendations and supporting evaluations as needed to facilitate use of the recommendations. The ITR team supports the remedial action objective (RAO) at C-400 to reduce the TCE source area via subsurface Electrical Resistance Heating (ERH). Further, the ITR team commends PPPO, their contractor team, regulators, and stakeholders for the significant efforts taken in preparing the 90% RDR. To maximize TCE removal at the target source area, several themes emerge from the review which the ITR team believes should be considered and addressed before implementing the thermal treatment. These themes include the need for: (1) Accurate and site-specific models as the basis to verify the ERH design for full-scale implementation for this challenging hydrogeologic setting; (2) Flexible project implementation and operation to allow the project team to respond to observations and data collected during construction and operation; (3) Defensible performance metrics and monitoring, appropriate for ERH, to ensure sufficient and efficient clean-up; and (4) Comprehensive (creative and diverse) contingencies

  8. REVIEW REPORT: BUILDING C-400 THERMAL TREATMENT 90 PERCENT REMEDIAL DESIGN REPORT AND SITE INVESTIGATION, PGDP, PADUCAH, KENTUCKY

    International Nuclear Information System (INIS)

    Looney, B; Jed Costanza, J; Eva Davis, E; Joe Rossabi, J; Lloyd Stewart, L; Hans Stroo, H

    2007-01-01

    On 9 April 2007, the U.S. Department of Energy (DOE) Headquarters, Office of Soil and Groundwater Remediation (EM-22) initiated an Independent Technical Review (ITR) of the 90% Remedial Design Report (RDR) and Site Investigation (RDSI) for thermal treatment of trichloroethylene (TCE) in the soil and groundwater in the vicinity of Building C-400 at the Paducah Gaseous Diffusion Plant (PGDP). The general ITR goals were to assess the technical adequacy of the 90% RDSI and provide recommendations sufficient for DOE to determine if modifications are warranted pertaining to the design, schedule, or cost of implementing the proposed design. The ultimate goal of the effort was to assist the DOE Paducah/Portsmouth Project Office (PPPO) and their contractor team in ''removing'' the TCE source zone located near the C-400 Building. This report provides the ITR findings and recommendations and supporting evaluations as needed to facilitate use of the recommendations. The ITR team supports the remedial action objective (RAO) at C-400 to reduce the TCE source area via subsurface Electrical Resistance Heating (ERH). Further, the ITR team commends PPPO, their contractor team, regulators, and stakeholders for the significant efforts taken in preparing the 90% RDR. To maximize TCE removal at the target source area, several themes emerge from the review which the ITR team believes should be considered and addressed before implementing the thermal treatment. These themes include the need for: (1) Accurate and site-specific models as the basis to verify the ERH design for full-scale implementation for this challenging hydrogeologic setting; (2) Flexible project implementation and operation to allow the project team to respond to observations and data collected during construction and operation; (3) Defensible performance metrics and monitoring, appropriate for ERH, to ensure sufficient and efficient clean-up; and (4) Comprehensive (creative and diverse) contingencies to address the

  9. Thermal Analysis of Iodine Satellite (iSAT) from Preliminary Design Review (PDR) to Critical Design Review (CDR)

    Science.gov (United States)

    Mauro, Stephanie

    2016-01-01

    The Iodine Satellite (iSAT) is a 12U cubesat with a primary mission to demonstrate the iodine fueled Hall Effect Thruster (HET) propulsion system. The spacecraft (SC) will operate throughout a one year mission in an effort to mature the propulsion system for use in future applications. The benefit of the HET is that it uses a propellant, iodine, which is easy to store and provides a high thrust-to-mass ratio. This paper will describe the thermal analysis and design of the SC between Preliminary Design Review (PDR) and Critical Design Review (CDR). The design of the satellite has undergone many changes due to a variety of challenges, both before PDR and during the time period discussed in this paper. Thermal challenges associated with the system include a high power density, small amounts of available radiative surface area, localized temperature requirements of the propulsion components, and unknown orbital parameters. The thermal control system is implemented to maintain component temperatures within their respective operational limits throughout the mission, while also maintaining propulsion components at the high temperatures needed to allow gaseous iodine propellant to flow. The design includes heaters, insulation, radiators, coatings, and thermal straps. Currently, the maximum temperatures for several components are near to their maximum operation limit, and the battery is close to its minimum operation limit. Mitigation strategies and planned work to solve these challenges will be discussed.

  10. Independent Technical Review Of The Focused Feasibility Study And Proposed Plan For Designated Solid Waste Management Units Contributing To The Southwest Groundwater Plume At The Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Looney, B.; Eddy-Dilek, C.; Amidon, M.; Rossabi, J.; Stewart, L.

    2011-01-01

    The U. S. Department of Energy (DOE) is currently developing a Proposed Plan (PP) for remediation of designated sources of chlorinated solvents that contribute contamination to the Southwest (SW) Groundwater Plume at the Paducah Gaseous Diffusion Plant (PGDP), in Paducah, KY. The principal contaminants in the SW Plume are trichloroethene (TCE) and other volatile organic compounds (VOCs); these industrial solvents were used and disposed in various facilities and locations at PGDP. In the SW plume area, residual TCE sources are primarily in the fine-grained sediments of the Upper Continental Recharge System (UCRS), a partially saturated zone that delivers contaminants downward into the coarse-grained Regional Gravel Aquifer (RGA). The RGA serves as the significant lateral groundwater transport pathway for the plume. In the SW Plume area, the four main contributing TCE source units are: (1) Solid Waste Management Unit (SWMU) 1 / Oil Landfarm; (2) C-720 Building TCE Northeast Spill Site (SWMU 211A); (3) C-720 Building TCE Southeast Spill Site (SWMU 211B); and (4) C-747 Contaminated Burial Yard (SWMU 4). The PP presents the Preferred Alternatives for remediation of VOCs in the UCRS at the Oil Landfarm and the C-720 Building spill sites. The basis for the PP is documented in a Focused Feasibility Study (FFS) (DOE, 2011) and a Site Investigation Report (SI) (DOE, 2007). The SW plume is currently within the boundaries of PGDP (i.e., does not extend off-site). Nonetheless, reasonable mitigation of the multiple contaminant sources contributing to the SW plume is one of the necessary components identified in the PGDP End State Vision (DOE, 2005). Because of the importance of the proposed actions DOE assembled an Independent Technical Review (ITR) team to provide input and assistance in finalizing the PP.

  11. INDEPENDENT TECHNICAL REVIEW OF THE FOCUSED FEASIBILITY STUDY AND PROPOSED PLAN FOR DESIGNATED SOLID WASTE MANAGEMENT UNITS CONTRIBUTING TO THE SOUTHWEST GROUNDWATER PLUME AT THE PADUCAH GASEOUS DIFFUSION PLANT

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Eddy-Dilek, C.; Amidon, M.; Rossabi, J.; Stewart, L.

    2011-05-31

    The U. S. Department of Energy (DOE) is currently developing a Proposed Plan (PP) for remediation of designated sources of chlorinated solvents that contribute contamination to the Southwest (SW) Groundwater Plume at the Paducah Gaseous Diffusion Plant (PGDP), in Paducah, KY. The principal contaminants in the SW Plume are trichloroethene (TCE) and other volatile organic compounds (VOCs); these industrial solvents were used and disposed in various facilities and locations at PGDP. In the SW plume area, residual TCE sources are primarily in the fine-grained sediments of the Upper Continental Recharge System (UCRS), a partially saturated zone that delivers contaminants downward into the coarse-grained Regional Gravel Aquifer (RGA). The RGA serves as the significant lateral groundwater transport pathway for the plume. In the SW Plume area, the four main contributing TCE source units are: (1) Solid Waste Management Unit (SWMU) 1 / Oil Landfarm; (2) C-720 Building TCE Northeast Spill Site (SWMU 211A); (3) C-720 Building TCE Southeast Spill Site (SWMU 211B); and (4) C-747 Contaminated Burial Yard (SWMU 4). The PP presents the Preferred Alternatives for remediation of VOCs in the UCRS at the Oil Landfarm and the C-720 Building spill sites. The basis for the PP is documented in a Focused Feasibility Study (FFS) (DOE, 2011) and a Site Investigation Report (SI) (DOE, 2007). The SW plume is currently within the boundaries of PGDP (i.e., does not extend off-site). Nonetheless, reasonable mitigation of the multiple contaminant sources contributing to the SW plume is one of the necessary components identified in the PGDP End State Vision (DOE, 2005). Because of the importance of the proposed actions DOE assembled an Independent Technical Review (ITR) team to provide input and assistance in finalizing the PP.

  12. The Iodine Satellite (iSat) Project Development Towards Critical Design Review (CDR)

    Science.gov (United States)

    Dankanich, John W.; Selby, Michael; Polzin, Kurt A.; Kamhawi, Hani; Hickman, Tyler; Byrne, Larry

    2016-01-01

    Despite the prevalence of Small Satellites in recent years, the systems flown to date have very limited propulsion capability. SmallSats are typically secondary payloads and have significant constraints for volume, mass, and power in addition to limitations on the use of hazardous propellants or stored energy (i.e. high pressure vessels). These constraints limit the options for SmallSat maneuverability. NASA's Space Technology Mission Directorate approved the iodine Satellite flight project for a rapid demonstration of iodine Hall thruster technology in a 12U configuration under the Small Spacecraft Technology Program. The project formally began in FY15 as a partnership between NASA MSFC, NASA GRC, and Busek Co, Inc., with the Air Force supporting the propulsion technology maturation. The team is in final preparation of the Critical Design Review prior to initiating the fabrication and integration phase of the project. The iSat project is on schedule for a launch opportunity in November 2017.

  13. Paducah site annual environmental report for 1996

    International Nuclear Information System (INIS)

    Belcher, G.

    1997-12-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US Department of Energy (DOE) leased the production areas of the site to the United States Enrichment Corporation (USEC). A subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. The DOE maintains responsibility for the environmental restoration, waste management, and depleted uranium hexafluoride cylinder program activities at the plant through its management contractor, Lockheed Martin Energy Systems. The purpose of this document is to summarize calendar year 1996 environmental monitoring activities for DOE activities at the Paducah Site. The DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities

  14. Paducah Site annual report for 1995

    International Nuclear Information System (INIS)

    Belcher, G.

    1997-01-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US department of Energy (DOE) leased the production areas of the site to the US Enrichment Corporation (USEC). A new subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. DOE maintains responsibility for the environmental restoration, waste management, and enrichment facilities activities at the plant through its management contractor, Lockheed Martin Energy Systems. The purpose of this document is to summarize calendar year 1995 environmental monitoring activities for DOE activities at the Paducah Site. DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities

  15. Paducah Site annual report for 1995

    Energy Technology Data Exchange (ETDEWEB)

    Belcher, G. [ed.

    1997-01-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US department of Energy (DOE) leased the production areas of the site to the US Enrichment Corporation (USEC). A new subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. DOE maintains responsibility for the environmental restoration, waste management, and enrichment facilities activities at the plant through its management contractor, Lockheed Martin Energy Systems. The purpose of this document is to summarize calendar year 1995 environmental monitoring activities for DOE activities at the Paducah Site. DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities.

  16. Paducah Site 1997 annual environmental report

    International Nuclear Information System (INIS)

    1998-12-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US Department of Energy (DOE) leased the production areas of the site to the US Enrichment Corporation (USEC). A subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. The DOE maintains responsibility for the environmental restoration, waste management, and depleted uranium hexafluoride cylinder program activities at the plant through its management contractor. The purpose of this document is to summarize calendar year 1997 environmental monitoring activities for DOE activities at the Paducah Site managed by Lockheed Martin Energy Systems. The DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities

  17. Paducah site annual environmental for 1996

    Energy Technology Data Exchange (ETDEWEB)

    Belcher, G. [ed.

    1997-12-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US Department of Energy (DOE) leased the production areas of the site to the United States Enrichment Corporation (USEC). A subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. The DOE maintains responsibility for the environmental restoration, waste management, and depleted uranium hexafluoride cylinder program activities at the plant through its management contractor, Lockheed Martin Energy Systems. The purpose of this document is to summarize calendar year 1996 environmental monitoring activities for DOE activities at the Paducah Site. The DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities.

  18. Paducah Site 1997 annual environmental report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US Department of Energy (DOE) leased the production areas of the site to the US Enrichment Corporation (USEC). A subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. The DOE maintains responsibility for the environmental restoration, waste management, and depleted uranium hexafluoride cylinder program activities at the plant through its management contractor. The purpose of this document is to summarize calendar year 1997 environmental monitoring activities for DOE activities at the Paducah Site managed by Lockheed Martin Energy Systems. The DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities.

  19. Regional flood hazard assessment of the Paducah and Portsmouth Gaseous Diffusion Plants

    International Nuclear Information System (INIS)

    Johnson, R.O.; Wang, J.C.; Lee, D.W.

    1991-01-01

    Regional flood-hazard assessments performed for the Paducah and Portsmouth Gaseous Diffusion Plants are reviewed, compared, and contrasted to determine the relationship of probable maximum flood methodology with respect to US Department of Energy design and evaluation guidelines. The Paducah assessment was carried out using probable minimum flood methodology, while the Portsmouth assessment utilized probabilistic techniques. Results indicated that regional flooding along nearby rivers would not inundate either plant, and that the guidelines were satisfied. A comparison of results indicated that the probable minimum flood recurrence interval associated with the Paducah assessment exceeded the 10,000-year requirement of the guidelines, while recurrence intervals obtained in the Portsmouth assessment could be above or below 10,000 years depending on the choice of the probabilistic model used to perform the assessment. It was concluded, based on an analysis of two data points, that smaller watersheds driven by single event storms could be assessed using probabilistic techniques, while probable maximum flood methodology could be applied to larger drainage basins flooded by storm sequences

  20. Paducah Site annual environmental report summary for 1994

    International Nuclear Information System (INIS)

    Horak, C.M.

    1996-02-01

    This pamphlet contains summaries of the environmental programs at the Paducah Gaseous Plant site, environmental monitoring and the results, and the impact of operations on the environment and the public for 1994

  1. RadNet Air Data From Paducah, KY

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Paducah, KY from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  2. Project plan for the background soils project for the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    The Background Soils Project for the Paducah Gaseous Diffusion Plant (BSPP) will determine the background concentration levels of selected naturally occurring metals, other inorganics, and radionuclides in soils from uncontaminated areas in proximity to the Paducah Gaseous Diffusion Plant (PGDP) in Paducah, Kentucky. The data will be used for comparison with characterization and compliance data for soils, with significant differences being indicative of contamination. All data collected as part of this project will be in addition to other background databases established for the PGDP. The BSPP will address the variability of surface and near-surface concentration levels with respect to (1) soil taxonomical types (series) and (2) soil sampling depths within a specific soil profile. The BSPP will also address the variability of concentration levels in deeper geologic formations by collecting samples of geologic materials. The BSPP will establish a database, with recommendations on how to use the data for contaminated site assessment, and provide data to estimate the potential human and health and ecological risk associated with background level concentrations of potentially hazardous constituents. BSPP data will be used or applied as follows.

  3. Project plan for the background soils project for the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    1995-09-01

    The Background Soils Project for the Paducah Gaseous Diffusion Plant (BSPP) will determine the background concentration levels of selected naturally occurring metals, other inorganics, and radionuclides in soils from uncontaminated areas in proximity to the Paducah Gaseous Diffusion Plant (PGDP) in Paducah, Kentucky. The data will be used for comparison with characterization and compliance data for soils, with significant differences being indicative of contamination. All data collected as part of this project will be in addition to other background databases established for the PGDP. The BSPP will address the variability of surface and near-surface concentration levels with respect to (1) soil taxonomical types (series) and (2) soil sampling depths within a specific soil profile. The BSPP will also address the variability of concentration levels in deeper geologic formations by collecting samples of geologic materials. The BSPP will establish a database, with recommendations on how to use the data for contaminated site assessment, and provide data to estimate the potential human and health and ecological risk associated with background level concentrations of potentially hazardous constituents. BSPP data will be used or applied as follows

  4. 77 FR 3255 - Notice of 229 Boundary Revision at the Paducah Gaseous Diffusion Plant

    Science.gov (United States)

    2012-01-23

    ... No: 2012-1214] DEPARTMENT OF ENERGY Notice of 229 Boundary Revision at the Paducah Gaseous Diffusion... entry into or upon areas, buildings, and other facilities of the Paducah Gaseous Diffusion Plant... provided in 10 CFR 860.4, into or upon this facility, installation, or real property of the Paducah Gaseous...

  5. 78 FR 30342 - United States Enrichment Corporation, Paducah Gaseous Diffusion Plant

    Science.gov (United States)

    2013-05-22

    ... COMMISSION United States Enrichment Corporation, Paducah Gaseous Diffusion Plant AGENCY: Nuclear Regulatory... Renewal of its Certificate of Compliance (CoC) for the Paducah Gaseous Diffusion Plant (PGDP). The existing CoC (No. GDP-1) authorizes operation of a uranium enrichment facility in Paducah, Kentucky. The...

  6. 76 FR 31599 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-06-01

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION...-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat..., June 23, 2011, 6 p.m. ADDRESSES: Barkley Centre, 111 Memorial Drive, Paducah, Kentucky 42001. FOR...

  7. 76 FR 11228 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-03-01

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION...-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. No. 92-463, 86 Stat..., March 17, 2011; 6 p.m. ADDRESSES: Barkley Centre, 111 Memorial Drive, Paducah, Kentucky 42001. FOR...

  8. 77 FR 51789 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-08-27

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION...-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat..., September 20, 2012, 6 p.m. ADDRESSES: Barkley Centre, 111 Memorial Drive, Paducah, Kentucky 42001. FOR...

  9. 75 FR 37782 - Environmental Management Site-Specific Advisory Board, Paducah, KY

    Science.gov (United States)

    2010-06-30

    ... Environmental Management Site-Specific Advisory Board, Paducah, KY AGENCY: Department of Energy (DOE). ACTION...-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat..., July 15, 2010, 6 p.m. ADDRESSES: Barkley Centre, 111 Memorial Drive, Paducah, Kentucky 42001. FOR...

  10. 77 FR 4799 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-01-31

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION...-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat..., February 16, 2012; 5:30 p.m. ADDRESSES: Barkley Centre, 111 Memorial Drive Paducah, Kentucky 42001. FOR...

  11. 77 FR 11516 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-02-27

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION...-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat..., March 15, 2012; 6 p.m. ADDRESSES: Barkley Centre, 111 Memorial Drive, Paducah, Kentucky 42001. FOR...

  12. 76 FR 17636 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-03-30

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION...-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat..., April 21, 2011; 6 p.m. ADDRESSES: Barkley Centre, 111 Memorial Drive, Paducah, Kentucky 42001. FOR...

  13. 77 FR 20014 - Environmental Management Site-Specific Advisory Board, Paducah, KY

    Science.gov (United States)

    2012-04-03

    ... Environmental Management Site-Specific Advisory Board, Paducah, KY AGENCY: Department of Energy (DOE). ACTION...-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat..., April 26, 2012, 6 p.m. ADDRESSES: Barkley Centre, 111 Memorial Drive, Paducah, Kentucky 42001. FOR...

  14. 78 FR 65389 - United States Enrichment Corporation, Paducah Gaseous Diffusion Plant

    Science.gov (United States)

    2013-10-31

    ... COMMISSION United States Enrichment Corporation, Paducah Gaseous Diffusion Plant AGENCY: Nuclear Regulatory...) for the Paducah Gaseous Diffusion Plant (PGDP). The current CoC for PGDP is set to expire on December... operation of a uranium enrichment facility in Paducah, Kentucky, using the gaseous ] diffusion process. PGDP...

  15. Site-specific earthquake response analysis for Paducah Gaseous Diffusion Plant, Paducah, Kentucky. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sykora, D.W.; Davis, J.J.

    1993-08-01

    The Paducah Gaseous Diffusion Plant (PGDP), owned by the US Department of Energy (DOE) and operated under contract by Martin Marietta Energy systems, Inc., is located southwest of Paducah, Kentucky. An aerial photograph and an oblique sketch of the plant are shown in Figures 1 and 2, respectively. The fenced portion of the plant consists of 748 acres. This plant was constructed in the 1950`s and is one of only two gaseous diffusion plants in operation in the United States; the other is located near Portsmouth, Ohio. The facilities at PGDP are currently being evaluated for safety in response to natural seismic hazards. Design and evaluation guidelines to evaluate the effects of earthquakes and other natural hazards on DOE facilities follow probabilistic hazard models that have been outlined by Kennedy et al. (1990). Criteria also established by Kennedy et al. (1990) classify diffusion plants as ``moderate hazard`` facilities. The US Army Engineer Waterways Experiment Station (WES) was tasked to calculate the site response using site-specific design earthquake records developed by others and the results of previous geotechnical investigations. In all, six earthquake records at three hazard levels and four individual and one average soil columns were used.

  16. Reassessment of liquefaction potential and estimation of earthquake- induced settlements at Paducah Gaseous Diffusion Plant, Paducah, Kentucky. Final report

    International Nuclear Information System (INIS)

    Sykora, D.W.; Yule, D.E.

    1996-04-01

    This report documents a reassessment of liquefaction potential and estimation of earthquake-induced settlements for the U.S. Department of Energy (DOE), Paducah Gaseous Diffusion Plant (PGDP), located southwest of Paducah, KY. The U.S. Army Engineer Waterways Experiment Station (WES) was authorized to conduct this study from FY91 to FY94 by the DOE, Oak Ridge Operations (ORO), Oak Ridge, TN, through Inter- Agency Agreement (IAG) No. DE-AI05-91OR21971. The study was conducted under the Gaseous Diffusion Plant Safety Analysis Report (GDP SAR) Program

  17. Paducah Gaseous Diffusion Plant Environmental report for 1990

    Energy Technology Data Exchange (ETDEWEB)

    Counce-Brown, D. (ed.)

    1991-09-01

    This two-part report, Paducah Gaseous Diffusion Plant Site Environmental Report for 1990, is published annually. It reflects the results of a comprehensive, year-round program to monitor the impact of operations at Paducah Gaseous Diffusion Plant (PGDP) on the area's groundwater and surface waters, soil, air quality, vegetation, and wildlife. In addition, an assessment of the effect of PGDP effluents on the resident human population is made. PGDP's overall goal for environmental management is to protect the environment and PGDP's neighbors and to maintain full compliance with all current regulations. The current environmental strategy is to identify any deficiencies and to develop a system to resolve them. The long-range goal of environmental management is to minimize the source of pollutants, to reduce the formation of waste, and to minimize hazardous waste by substitution of materials.

  18. Paducah Gaseous Diffusion Plant environmental report for 1992

    International Nuclear Information System (INIS)

    Horak, C.M.

    1993-09-01

    This two-part report, Paducah Gaseous Diffusion Plant Environmental Report for 1992, is published annually. It reflects the results of an environmental monitoring program designed to quantify potential increases in the concentration of contaminants and potential doses to the resident human population. The Paducah Gaseous Diffusion Plant (PGDP) overall goal for environmental management is to protect the environment and PGDP's neighbors and to maintain full compliance with all current regulations. The current environmental strategy is to identify any deficiencies and to develop a system to resolve them. The long-range goal of environmental management is to minimize the source of pollutants, reduce the generation of waste, and minimize hazardous waste by substitution of materials

  19. Paducah Gaseous Diffusion Plant environmental report for 1992

    Energy Technology Data Exchange (ETDEWEB)

    Horak, C.M. [ed.] [Martin Marietta Energy Systems, Inc., Oak Ridge, TN (United States)

    1993-09-01

    This two-part report, Paducah Gaseous Diffusion Plant Environmental Report for 1992, is published annually. It reflects the results of an environmental monitoring program designed to quantify potential increases in the concentration of contaminants and potential doses to the resident human population. The Paducah Gaseous Diffusion Plant (PGDP) overall goal for environmental management is to protect the environment and PGDP`s neighbors and to maintain full compliance with all current regulations. The current environmental strategy is to identify any deficiencies and to develop a system to resolve them. The long-range goal of environmental management is to minimize the source of pollutants, reduce the generation of waste, and minimize hazardous waste by substitution of materials.

  20. Paducah Site annual environmental report summary for 1995

    International Nuclear Information System (INIS)

    Belcher, G.

    1997-01-01

    This report contains summaries of the environmental programs at the Paducah Site, as well as the impacts of its operations on the environment and the public for 1995. The results of environmental monitoring are presented. The goal is to keep emissions as low as possible, enhance the strict safety controls that are in place and use state-of-the-art technology to complete environmental remediation projects in the most cost-effective and efficient manner possible

  1. Proposed sale of radioactively contaminated nickel ingots located at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    1995-10-01

    The U.S. Department of Energy (DOE) proposes to sell 8,500 radioactively contaminated nickel ingots (9.350 short tons), currently in open storage at the Paducah Gaseous Diffusion Plant (PGDP), to Scientific Ecology Group, Inc. (SEG) for decontamination and resale on the international market. SEG would take ownership of the ingots when they are loaded for transport by truck to its facility in Oak Ridge, Tennessee. SEG would receive approximately 200 short tons per month over approximately 48 months (an average of 180 ingots per month). The nickel decontamination process specified in SEG's technical proposal is considered the best available technology and has been demonstrated in prototype at SEG. The resultant metal for resale would have contamination levels between 0.3 and 20 becquerel per gram (Bq/g). The health hazards associated with release of the decontaminated nickel are minimal. The activity concentration of the end product would be further reduced when the nickel is combined with other metals to make stainless steel. Low-level radioactive waste from the SEG decontamination process, estimated to be approximately 382 m 3 (12,730 ft), would be shipped to a licensed commercial or DOE disposal facility. If the waste were packaged in 0.23 m 3 -(7.5 ft 3 -) capacity drums, approximately 1,500 to 1,900 drums would be transported over the 48-month contract period. Impacts from the construction of decontamination facilities and the selected site are minimal

  2. 76 FR 53494 - In the Matter of United States Enrichment Corporation; Paducah Gaseous Enrichment Plant...

    Science.gov (United States)

    2011-08-26

    ... removable contamination, unless otherwise authorized by Health Physics. USEC- Paducah is required by... involved in the routine activity of swapping cylinders from the enrichment cascade in the 337A feed...) regarding activities at the Paducah facility. The purpose of the investigation was to determine whether an...

  3. An interim report to the manager of the Paducah Gaseous Diffusion Plant from the Paducah Environmental Advisory Committee

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, G.D.

    1987-10-01

    The Paducah Environmental Advisory Committee was formed as: (1) an outgrowth of other Environmental Advisory Committees already in existence at Oak Ridge and other Martin Marietta Energy Systems plants; (2) a result of public concern following significant nuclear incidents at Bhopal and Chernobyl; (3) a result of the new direction and commitment of the management of the Paducah Gaseous Diffusion Plant following contract acquisition by Martin Marietta Energy Systems; and (4) a means of reducing and/or preventing local and/or public concern regarding the activities of and potential risks created by PGDP. This report discusses the following issues and concerns of the Committee arrived at through a series of meetings: (1) groundwater monitoring; (2) long-range tails storage; C-404, scrap yrads, and PCB and TCE cleanup; nuclear criticality plan and alarm systems; documentation of historical data regarding hazardous waste burial grounds; dosimeter badges; and asbestos handling and removal.

  4. An interim report to the manager of the Paducah Gaseous Diffusion Plant from the Paducah Environmental Advisory Committee

    International Nuclear Information System (INIS)

    Jackson, G.D.

    1987-10-01

    The Paducah Environmental Advisory Committee was formed as: (1) an outgrowth of other Environmental Advisory Committees already in existence at Oak Ridge and other Martin Marietta Energy Systems plants; (2) a result of public concern following significant nuclear incidents at Bhopal and Chernobyl; (3) a result of the new direction and commitment of the management of the Paducah Gaseous Diffusion Plant following contract acquisition by Martin Marietta Energy Systems; and (4) a means of reducing and/or preventing local and/or public concern regarding the activities of and potential risks created by PGDP. This report discusses the following issues and concerns of the Committee arrived at through a series of meetings: (1) groundwater monitoring; (2) long-range tails storage; C-404, scrap yrads, and PCB and TCE cleanup; nuclear criticality plan and alarm systems; documentation of historical data regarding hazardous waste burial grounds; dosimeter badges; and asbestos handling and removal

  5. An interim report to the manager of the Paducah Gaseous Diffusion Plant from the Paducah Environmental Advisory Committee

    International Nuclear Information System (INIS)

    Jackson, G.D.

    1987-01-01

    The Paducah Environmental Advisory Committee was formed as: (1) an outgrowth of other Environmental Advisory Committees already in existence at Oak Ridge and other Martin Marietta Energy Systems plants; (2) a result of public concern following significant nuclear incidents at Bhopal and Chernobyl; (3) a result of the new direction and commitment of the management of the Paducah Gaseous Diffusion Plant following contract acquisition by Martin Marietta Energy Systems; and (4) a means of reducing and/or preventing local and/or public concern regarding the activities of and potential risks created by PGDP. This report discusses the following issues and concerns of the Committee arrived at through a series of meetings: (1) groundwater monitoring; (2) long-range tails storage; C-404, scrap yrads, and PCB and TCE cleanup; nuclear criticality plan and alarm systems; documentation of historical data regarding hazardous waste burial grounds; dosimeter badges; and asbestos handling and removal

  6. Local drainage analyses of the Paducah and Portsmouth Gaseous Diffusion Plants during an extreme storm

    International Nuclear Information System (INIS)

    Johnson, R.O.; Wang, J.C.; Lee, D.W.

    1993-01-01

    Local drainage analyses have been performed for the Paducah and Portsmouth Gaseous Diffusion Plants during an extreme storm having an approximate 10,000-yr recurrence interval. This review discusses the methods utilized to accomplish the analyses in accordance with US Department of Energy (DOE) design and evaluation guidelines, and summarizes trends, results, generalizations, and uncertainties applicable to other DOE facilities. Results indicate that some culverts may be undersized, and that the storm sewer system cannot drain the influx of precipitation from the base of buildings. Roofs have not been designed to sustain ponding when the primary drainage system is clogged. Some underground tunnels, building entrances, and ground level air intakes may require waterproofing

  7. New draft.cdr

    African Journals Online (AJOL)

    HP USER

    Medicina Oral Patologia Oral Y Cirugia Bucal,. 13(10): 627-632. Benamer MH, Elmangoush AM (2006). Lingual osseous choristoma: case report and review of literature. Libyan Journal of Medicine, 06:9-11. Chou LS, Hansen LS & Daniels TE (1991). Choristomas of the oral cavity: a review. Oral Surgery Oral. Medicine Oral ...

  8. Inorganic soil and groundwater chemistry near Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    Moore, G.K.

    1995-03-01

    Near-surface soils, boreholes, and sediments near the Paducah Gaseous Diffusion Plant (PGDP) were sampled in 1989-91 as were monitoring wells, TVA wells, and privately-owned wells. Most wells were sampled two or three times. The resulting chemical analyses have been published in previous reports and have been previously described (CH2M HILL 1991, 1992; Clausen et al. 1992). The two reports by CH2M HILL are controversial, however, because, the concentrations of some constituents were reported to exceed background levels or drinking water standards and because both on-site (within the perimeter fence at PGDP) and off-site pollution was reported to have occurred. The groundwater samples upon which these interpretations were based may not be representative, however. The CH2M HILL findings are discussed in the report. The purpose of this report is to characterize the inorganic chemistry of groundwater and soils near PGDP, using data from the CH2M HILL reports (1991, 1992), and to determine whether or not any contamination has occurred. The scope is limited to analysis and interpretation of data in the CH2M HILL reports because previous interpretations of these data may not be valid, because samples were collected in a relatively short period of time at several hundred locations, and because the chemical analyses are nearly complete. Recent water samples from the same wells were not considered because the characterization of inorganic chemistry for groundwater and soil requirements only one representative sample and an accurate analysis from each location

  9. Inorganic soil and groundwater chemistry near Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Moore, G.K. [Tennessee Univ., Knoxville, TN (United States)

    1995-03-01

    Near-surface soils, boreholes, and sediments near the Paducah Gaseous Diffusion Plant (PGDP) were sampled in 1989-91 as were monitoring wells, TVA wells, and privately-owned wells. Most wells were sampled two or three times. The resulting chemical analyses have been published in previous reports and have been previously described (CH2M HILL 1991, 1992; Clausen et al. 1992). The two reports by CH2M HILL are controversial, however, because, the concentrations of some constituents were reported to exceed background levels or drinking water standards and because both on-site (within the perimeter fence at PGDP) and off-site pollution was reported to have occurred. The groundwater samples upon which these interpretations were based may not be representative, however. The CH2M HILL findings are discussed in the report. The purpose of this report is to characterize the inorganic chemistry of groundwater and soils near PGDP, using data from the CH2M HILL reports (1991, 1992), and to determine whether or not any contamination has occurred. The scope is limited to analysis and interpretation of data in the CH2M HILL reports because previous interpretations of these data may not be valid, because samples were collected in a relatively short period of time at several hundred locations, and because the chemical analyses are nearly complete. Recent water samples from the same wells were not considered because the characterization of inorganic chemistry for groundwater and soil requirements only one representative sample and an accurate analysis from each location.

  10. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    JMBR: A Peer-review Journal of Biomedical Sciences. December 2013, Vol. 12 No.2 pp 166-172. ABSTRACT. Cadmium and Lead are extremely toxic metals found in industrial workplaces. They are also found in some industrial paints and may represent hazards when sprayed. Occupational exposure is a common cause ...

  11. JMBR vol 7.cdr

    African Journals Online (AJOL)

    Tope

    Hence, it may be necessary to use rheomodulators in the management of diabetes mellitus. INTRODUCTION. Cardiovascular morbidity and mortality represent a main challenge in diabetic. 1, 2 patients . Aggressive blood pressure control. JMBR: A Peer-review Journal of Biomedical Sciences. 2008 Edition Vol.7 Nos.1 & 2.

  12. Secondhand smoke and indoor public spaces in Paducah, Kentucky.

    Science.gov (United States)

    Jones, Shawn C; Travers, Mark J; Hahn, Ellen J; Robertson, Heather; Lee, Kiyoung; Higbee, Cheryl; Hyland, Andrew

    2006-07-01

    Secondhand smoke (SHS) is the third leading cause of preventable death in the United States. It is responsible for an estimated 3,000 lung cancer deaths annually in never-smokers in the US. It also accounts for over 35,000 deaths annually from coronary heart disease in never-smokers. It increases the number and severity of asthmatic attacks in over 300,000 asthmatic children each year, and is associated with Sudden Infant Death Syndrome and middle ear infections, in addition to other illnesses in children. The purpose of this study was to examine indoor air quality in a sample of hospitality venues in Paducah, Kentucky. The relation between indoor air pollution and the presence of on premises smoking was assessed. A Personal Aerosol Monitor was used to sample and record the levels of respirable suspended particles in the air. The SidePak uses a built-in sampling pump that draws air through the device and the particulate matter in the air scatters the light from a laser. Based on this light scattering, the device determines to assess the real-time concentration of particles smaller than 2.5 microm in micrograms per cubic meter, or PM2.5. The average PM2.5 concentration in the eleven locations sampled in Paducah, Kentucky, was 177 microg/m3. The average fine particle pollution level in the non-smoking sections tested was 87 microg/m3, which is 29 times higher than the average fine particle pollution level in smoke-free air or 6 times higher than outdoor air in Paducah. The average PM2.5 level across all nine smoking-permitted hospitality locations sampled in Paducah was 200 microg/m3. For a full-time employee in the venues sampled in this study, the average annual PM2.5 exposure would be 46 microg/m3 (assuming exposure to 200 microg/m3 on the job, exposure to zero particles off the job, and a 40-hour work week). The EPA average annual PM2.5 limit is exceeded by 3.1 times due solely to occupational exposure. Of the ten locations visited that permit indoor smoking, the

  13. Evaluation of seismic hazard at the Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Toro, G.R.; McGuire, R.K.

    1991-01-01

    Seismic hazard at the Paducah Gaseous Diffusion Plant is evaluated using a formulation that considers the rupture dimensions of potential large earthquakes in the New Madrid region. The New Madrid source zone is modeled as a system of parallel faults. A characteristic-magnitude model, based on historical seismic city and paleoseismic studies, describes seismicity in the New madrid source zone. The attenuation functions reflect distance saturation caused by the rupture size of large earthquakes. Preliminary results from this seismic hazard analysis are presented and compared to results obtained using the EPRI and LLNL methodologies

  14. Post-CDR NPOESS VIIRS sensor design and performance

    Science.gov (United States)

    Scalione, Tanya; Swenson, Hilmer W.; De Luccia, Frank; Schueler, Carl; Clement, John E.; Darnton, Lane

    2004-02-01

    This paper summarizes post-critical design review (CDR) design refinements and performance estimate updates to the National Polar-orbiting Operational Environmental Satellite Systems (NPOESS) Visible Infrared Imager Radiometer Suite (VIIRS) sensor. The design changes reduced manufacturing and performance risk to meet VIIRS sensor performance specifications. Electro-Magnetic Compatibility (EMC) and Electro-Magnetic Interference (EMI) requirements drove increased shielding and cable modifications. A telescope design modification was also required to remove modulated instrument background (MIB) discovered in the CDR optical design. Performance predictions were then generated from models and demonstration hardware based on the design refinements, and these are also reported here. VIIRS risk-reduction will continue as the Engineering Development Unit (EDU) is assembled and tested over the next year facilitating performance verification and lowering flight unit development risk.

  15. Environmental assessment for the construction and operation of waste storage facilities at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    1994-06-01

    DOE is proposing to construct and operate 3 waste storage facilities (one 42,000 ft 2 waste storage facility for RCRA waste, one 42,000 ft 2 waste storage facility for toxic waste (TSCA), and one 200,000 ft 2 mixed (hazardous/radioactive) waste storage facility) at Paducah. This environmental assessment compares impacts of this proposed action with those of continuing present practices aof of using alternative locations. It is found that the construction, operation, and ultimate closure of the proposed waste storage facilities would not significantly affect the quality of the human environment within the meaning of NEPA; therefore an environmental impact statement is not required

  16. Partnering efforts at the Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Warren, C.B.

    1995-01-01

    Before individuals or agencies can effectively work together to solve common problems, they must first agree on exactly what those problems are and establish common goals and methods that will lead to mutually acceptable solutions. Then, they must make a conscientious effort to form a cohesive team that focuses on the established goals and deemphasize traditional roles, which may in some instances be considered adversarial. This kind of teamwork/partnering process can be more difficult, though not impossible, to achieve in cases where there are traditional (real or imagined) adversarial relationships between the parties, i.e. regulator vs. regulated. The US Department of Energy Site Office (DOE) at Paducah, Kentucky, the Kentucky Department of Environmental Protection (KDEP) and the US Environmental Protection Agency, Region IV (EPA) have made t strides toward teamwork and partnering at DOE's Paducah Gaseous Diffusion Plant. They have accomplished this in a number of ways, which will be discussed in greater detail but first and foremost, the agencies agreed up front that they had mutual goals and interests. These goals are to protect public health and the environment in a cost-effective and timely manner, taking care to make the wisest use of public resources (tax dollars); to evaluate and minimize risks, and to achieve ''Win-Win'' for all parties concerned

  17. Paducah Gaseous Diffusion Plant Annual Site Environmental Report for 1993

    International Nuclear Information System (INIS)

    1994-10-01

    The purpose of this document is to summarize effluent monitoring and environmental surveillance results and compliance with environmental laws, regulations, and orders at the Paducah Gaseous Diffusion Plant (PGDP). Environmental monitoring at PGDP consists of two major activities: effluent monitoring and environmental surveillance. Effluent monitoring is direct measurement or the collection and analysis of samples of liquid and gaseous discharges to the environment. Environmental surveillance is direct measurement or the collection and analysis of samples of air, water, soil, foodstuff, biota, and other media. Environmental monitoring is performed to characterize and quantify contaminants, assess radiation exposures of members of the public, demonstrate compliance with applicable standards and permit requirements, and detect and assess the effects (if any) on the local environment. Multiple samples are collected throughout the year and are analyzed for radioactivity, chemical content, and various physical attributes

  18. Paducah Gaseous Diffusion Plant Annual Site Environmental Report for 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-01

    The purpose of this document is to summarize effluent monitoring and environmental surveillance results and compliance with environmental laws, regulations, and orders at the Paducah Gaseous Diffusion Plant (PGDP). Environmental monitoring at PGDP consists of two major activities: effluent monitoring and environmental surveillance. Effluent monitoring is direct measurement or the collection and analysis of samples of liquid and gaseous discharges to the environment. Environmental surveillance is direct measurement or the collection and analysis of samples of air, water, soil, foodstuff, biota, and other media. Environmental monitoring is performed to characterize and quantify contaminants, assess radiation exposures of members of the public, demonstrate compliance with applicable standards and permit requirements, and detect and assess the effects (if any) on the local environment. Multiple samples are collected throughout the year and are analyzed for radioactivity, chemical content, and various physical attributes.

  19. Mortality patterns among Paducah Gaseous Diffusion Plant workers.

    Science.gov (United States)

    Chan, Caroline; Hughes, Therese S; Muldoon, Susan; Aldrich, Tim; Rice, Carol; Hornung, Richard; Brion, Gail; Tollerud, David J

    2010-07-01

    To determine whether Paducah Gaseous Diffusion Plant workers had mortality patterns that differed from the general US population and to investigate whether mortality patterns were associated with job title or workplace exposures. A retrospective occupational cohort mortality study was conducted on 6759 workers. Standardized mortality ratio analyses compared the cohort with the referent US population. Internal comparisons producing standardized rate ratios were conducted by job title, metal exposure, and cumulative internal and external radiation exposures. Overall mortality and cancer rates were lower than the referent population, reflecting a strong healthy worker effect. Individual not significant standardized mortality ratios and standardized rate ratios were noted for cancers of the lymphatic and hematopoietic tissue. Although relatively low exposures to radiation and metals did not produce statistically significant health effects, no significant elevations for lymphatic and hematopoietic cancers were consistent with previous studies of nuclear workers.

  20. Environmental assessment for the construction and operation of waste storage facilities at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-06-01

    DOE is proposing to construct and operate 3 waste storage facilities (one 42,000 ft{sup 2} waste storage facility for RCRA waste, one 42,000 ft{sup 2} waste storage facility for toxic waste (TSCA), and one 200,000 ft{sup 2} mixed (hazardous/radioactive) waste storage facility) at Paducah. This environmental assessment compares impacts of this proposed action with those of continuing present practices aof of using alternative locations. It is found that the construction, operation, and ultimate closure of the proposed waste storage facilities would not significantly affect the quality of the human environment within the meaning of NEPA; therefore an environmental impact statement is not required.

  1. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1993 to December 1994

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A. [ed.

    1996-05-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). The PGDP BMP was implemented in 1987 by the University of Kentucky. Research staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) served as reviewers and advisers to the University of Kentucky. Beginning in fall 1991, ESD added data collection and report preparation to its responsibilities for the PGDP BMP. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, (3) document the effects of pollution abatement facilities on stream biota, and (4) recommend any program improvements that would increase effluent treatability. In September 1992, a renewed Kentucky Pollutant Discharge Elimination System (KPDES) permit was issued to PGDP. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report includes ESD activities occurring from December 1993 to December 1994, although activities conducted outside this time period are included as appropriate.

  2. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1993 to December 1994

    International Nuclear Information System (INIS)

    Kszos, L.A.

    1996-05-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). The PGDP BMP was implemented in 1987 by the University of Kentucky. Research staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) served as reviewers and advisers to the University of Kentucky. Beginning in fall 1991, ESD added data collection and report preparation to its responsibilities for the PGDP BMP. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, (3) document the effects of pollution abatement facilities on stream biota, and (4) recommend any program improvements that would increase effluent treatability. In September 1992, a renewed Kentucky Pollutant Discharge Elimination System (KPDES) permit was issued to PGDP. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report includes ESD activities occurring from December 1993 to December 1994, although activities conducted outside this time period are included as appropriate

  3. The CDR subsystem of the COMPASS experiment

    International Nuclear Information System (INIS)

    Kral, A.; Liska, T.

    2005-01-01

    COMPASS (COmmon Muon Proton Apparatus for Structure and Spectroscopy) is a high-energy physics experiment at the Super Proton Synchrotron (SPS) at CERN in Geneva, Switzerland. The purpose of this experiment is to study the hadron structure and hadron spectrum using high intensity muon and hadron beams. A set of programs which transfer the data taken by the on-line experimental systems to the central data storage CASTOR are required. We use the software package called Central Data Recording (CDR) system. This paper briefly describes architecture of CDR system, system functionality and ongoing tasks for the future. (author)

  4. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) 99 Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD

  5. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant

    Energy Technology Data Exchange (ETDEWEB)

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) [sup 99]Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD.

  6. Preliminary study of PCBs in raccoons living on or near the Paducah Gaseous Diffusion Plant, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Halbrook, Richard S. [Southern Illinois Univ., Carbondale, IL (United States). Dept. of Zoology. Cooperative Wildlife Research Lab. Kentucky Research Consortium for Energy and Environment

    2016-01-15

    The “Ecological Monitoring at the Paducah Gaseous Diffusion Plant: Historical Evaluation and Guidelines for Future Monitoring” report (Halbrook, et al. 2007) recommended the raccoon as a species for study at the Paducah Gaseous Diffusion Plant (PGDP). This species was selected to fill data gaps in ecological resources and provide resource managers with knowledge that will be valuable in making decisions and implementing specific actions to safeguard ecological resources and reduce human exposure. The current paper reports results of a preliminary evaluation to establish protocols for collection of tissues and initial screening of polychlorinated biphenyls (PCBs) in raccoons collected near the PGDP. These data are useful in developing future more comprehensive studies.

  7. Bioavailability study for the Paducah Gaseous Diffusion Plant

    Energy Technology Data Exchange (ETDEWEB)

    Phipps, T.L.; Kszos, L.A.

    1996-08-01

    The overall purpose of this plan is to assess the bioavailability of metals in the continuous and intermittent outfalls. The results may be used to determine alternative metal limits that more appropriately measure the portion of metal present necessary for toxicity to aquatic life. These limits must remain protective of in-stream aquatic life; thus, the highest concentration of metal in the water will be determined concurrently with an assessment of acute or chronic toxicity on laboratory tests. Using the method developed by the Kentucky Division of Water (KDOW), biomonitoring results and chemical data will be used to recommend alternative metal limits for the outfalls of concern. The data will be used to meet the objectives of the study: (1) evaluate the toxicity of continuous outfalls and intermittent outfalls at Paducah Gaseous Diffusion Plant; (2) determine the mean ratio of dissolved to Total Recoverable metal for Cd, Cr, Cu, Pb, Ni, and Zn in the continuous and intermittent outfalls; (3) determine whether the concentration of total recoverable metal discharged causes toxicity to fathead minnows and /or Ceriodaphnia; and (4) determine alternative metal limits for each metal of concern (Cd, Cr, Cu, Pb, Ni, and Zn).

  8. Real Time Demonstration Project XRF Performance Evaluation Report for Paducah Gaseous Diffusion Plant AOC 492

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Robert L [Argonne National Laboratory

    2008-04-03

    This activity was undertaken to demonstrate the applicability of market-available XRF instruments to quantify metal concentrations relative to background and risk-based action and no action levels in Paducah Gaseous Diffusion Plant (PGDP) soils. As such, the analysis below demonstrates the capabilities of the instruments relative to soil characterization applications at the PGDP.

  9. Safety analysis report on the ''Paducah Tiger'' protective overpack for 10-ton cylinders of uranium hexafluoride

    International Nuclear Information System (INIS)

    Stitt, D.H.

    1975-01-01

    The ''Paducah Tiger'' is a protective overpack used in shipment of 10-ton cylinders of enriched UF 6 . The calculations and tests are described which made and which indicate that the overpack is in compliance with the type B packaging requirements of ERDA Manual Chapter 0529 and Title 10 Code Federal Regulations Part 71. (U.S.)

  10. 78 FR 78952 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-12-27

    ..., Paducah, Kentucky 42001. FOR FURTHER INFORMATION CONTACT: Rachel Blumenfeld, Deputy Designated Federal... accommodations due to a disability, please contact Rachel Blumenfeld as soon as possible in advance of the... contact Rachel Blumenfeld at the telephone number listed above. Requests must be received as soon as...

  11. 78 FR 73519 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-12-06

    ..., Paducah, Kentucky 42001. FOR FURTHER INFORMATION CONTACT: Rachel Blumenfeld, Deputy Designated Federal... accommodations due to a disability, please contact Rachel Blumenfeld as soon as possible in advance of the... contact Rachel Blumenfeld at the telephone number listed above. Requests must be received as soon as...

  12. 78 FR 54460 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-09-04

    ..., Paducah, Kentucky 42001. FOR FURTHER INFORMATION CONTACT: Rachel Blumenfeld, Deputy Designated Federal... require special accommodations due to a disability, please contact Rachel Blumenfeld as soon as possible... to agenda items should contact Rachel Blumenfeld at the telephone number listed above. Requests must...

  13. 78 FR 45518 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-07-29

    ..., Paducah, Kentucky 42001. FOR FURTHER INFORMATION CONTACT: Rachel Blumenfeld, Deputy Designated Federal... require special accommodations due to a disability, please contact Rachel Blumenfeld as soon as possible... to agenda items should contact Rachel Blumenfeld at the telephone number listed above. Requests must...

  14. 78 FR 16260 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-03-14

    ..., Paducah, Kentucky 42001. FOR FURTHER INFORMATION CONTACT: Rachel Blumenfeld, Deputy Designated Federal... accommodations due to a disability, please contact Rachel Blumenfeld as soon as possible in advance of the... contact Rachel Blumenfeld at the telephone number listed above. Requests must be received as soon as...

  15. 78 FR 7767 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-02-04

    ..., Paducah, Kentucky 42001. FOR FURTHER INFORMATION CONTACT: Rachel Blumenfeld, Deputy Designated Federal... accommodations due to a disability, please contact Rachel Blumenfeld as soon as possible in advance of the... contact Rachel Blumenfeld at the telephone number listed above. Requests must be received as soon as...

  16. 78 FR 63172 - Environmental Management Site-Specific Advisory Board, Paducah; Meeting

    Science.gov (United States)

    2013-10-23

    ..., 111 Memorial Drive, Paducah, Kentucky 42001. FOR FURTHER INFORMATION CONTACT: Rachel Blumenfeld... require special accommodations due to a disability, please contact Rachel Blumenfeld as soon as possible... to agenda items should contact Rachel Blumenfeld at the telephone number listed above. Requests must...

  17. 77 FR 59598 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-09-28

    ..., Paducah, Kentucky 42001. FOR FURTHER INFORMATION CONTACT: Rachel Blumenfeld, Deputy Designated Federal... accommodations due to a disability, please contact Rachel Blumenfeld as soon as possible in advance of the... contact Rachel Blumenfeld at the telephone number listed above. Requests must be received as soon as...

  18. 75 FR 82002 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-12-29

    ...-82003] [FR Doc No: 2010-32821] DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory... announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The... the Board is to make recommendations to DOE-EM and site management in the areas of environmental...

  19. 77 FR 2282 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-01-17

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy. ACTION: Notice of... of open meeting announcing a meeting on January 19, 2012, of the Environmental Management Site... Washington, DC, on January 12, 2012. LaTanya R. Butler, Acting Deputy Committee Management Officer. BILLING...

  20. 75 FR 24686 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-05-05

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site... management in the areas of environmental restoration, waste management and related activities. Tentative...

  1. 76 FR 61350 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-10-04

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site-Specific... management in the areas of environmental restoration, waste management, and related activities. Tentative...

  2. 77 FR 31837 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-05-30

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site... and site management in the areas of environmental restoration, waste management and related activities...

  3. 75 FR 54600 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-09-08

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE) ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site... management in the areas of environmental restoration, waste management and related activities. Tentative...

  4. 75 FR 66074 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-10-27

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site... management in the areas of environmental restoration, waste management and related activities. Tentative...

  5. 75 FR 9404 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-03-02

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site... management in the areas of environmental restoration, waste management and related activities. Tentative...

  6. 76 FR 80355 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-12-23

    ...] [FR Doc No: 2011-32913] DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board... a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The... environmental restoration, waste management, and related activities. Tentative Agenda Call to Order...

  7. 78 FR 26635 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-05-07

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy. ACTION: Notice of... of open meeting announcing a meeting on May 16, 2013 of the Environmental Management Site-Specific..., Deputy Committee Management Officer. BILLING CODE 6450-01-P ...

  8. 75 FR 61711 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-10-06

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site... management in the areas of environmental restoration, waste management and related activities. Tentative...

  9. 76 FR 48148 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-08-08

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site... management in the areas of environmental restoration, waste management and related activities. Tentative...

  10. 76 FR 5147 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-01-28

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site... management in the areas of environmental restoration, waste management and related activities. Tentative...

  11. 77 FR 43583 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-07-25

    ... Environmental Management Site-Specific Advisory Board, Paducah AGENCY: Department of Energy (DOE). ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site... management in the areas of environmental restoration, waste management and related activities. Tentative...

  12. Serum repressing efflux pump CDR1 in Candida albicans

    Directory of Open Access Journals (Sweden)

    Fan Jen-Chung

    2006-07-01

    Full Text Available Abstract Background In the past decades, the prevalence of candidemia has increased significantly and drug resistance has also become a pressing problem. Overexpression of CDR1, an efflux pump, has been proposed as a major mechanism contributing to the drug resistance in Candida albicans. It has been demonstrated that biological fluids such as human serum can have profound effects on antifungal pharmacodynamics. The aim of this study is to understand the effects of serum in drug susceptibility via monitoring the activity of CDR1 promoter of C. albicans. Results The wild-type C. albicans cells (SC5314 but not the cdr1/cdr1 mutant cells became more susceptible to the antifungal drug when the medium contained serum. To understand the regulation of CDR1 in the presence of serum, we have constructed CDR1 promoter-Renilla luciferase (CDR1p-RLUC reporter to monitor the activity of the CDR1 promoter in C. albicans. As expected, the expression of CDR1p-RLUC was induced by miconazole. Surprisingly, it was repressed by serum. Consistently, the level of CDR1 mRNA was also reduced in the presence of serum but not N-acetyl-D-glucosamine, a known inducer for germ tube formation. Conclusion Our finding that the expression of CDR1 is repressed by serum raises the question as to how does CDR1 contribute to the drug resistance in C. albicans causing candidemia. This also suggests that it is important to re-assess the prediction of in vivo therapeutic outcome of candidemia based on the results of standard in vitro antifungal susceptibility testing, conducted in the absence of serum.

  13. Occupational exposure to trichloroethylene and cancer risk for workers at the Paducah Gaseous Diffusion Plant.

    Science.gov (United States)

    Bahr, Debra E; Aldrich, Timothy E; Seidu, Dazar; Brion, Gail M; Tollerud, David J; Muldoon, Susan; Reinhart, Nancy; Youseefagha, Ahmed; McKinney, Paul; Hughes, Therese; Chan, Caroline; Rice, Carol; Brewer, David E; Freyberg, Ronald W; Mohlenkamp, Adriane Moser; Hahn, Kristen; Hornung, Richard; Ho, Mona; Dastidar, Aniruddha; Freitas, Samantha; Saman, Daniel; Ravdal, Hege; Scutchfield, Douglas; Eger, Kenneth J; Minor, Steve

    2011-03-01

    The Paducah Gaseous Diffusion Plant (PGDP) became operational in 1952; it is located in the western part of Kentucky. We conducted a mortality study for adverse health effects that workers may have suffered while working at the plant, including exposures to chemicals. We studied a cohort of 6820 workers at the PGDP for the period 1953 to 2003; there were a total of 1672 deaths to cohort members. Trichloroethylene (TCE) is a specific concern for this workforce; exposure to TCE occurred primarily in departments that clean the process equipment. The Life Table Analysis System (LTAS) program developed by NIOSH was used to calculate the standardized mortality ratios for the worker cohort and standardized rate ratio relative to exposure to TCE (the U.S. population is the referent for ageadjustment). LTAS calculated a significantly low overall SMR for these workers of 0.76 (95% CI: 0.72-0.79). A further review of three major cancers of interest to Kentucky produced significantly low SMR for trachea, bronchus, lung cancer (0.75, 95% CI: 0.72-0.79) and high SMR for Non-Hodgkin's lymphoma (NHL) (1.49, 95% CI: 1.02-2.10). No significant SMR was observed for leukemia and no significant SRRs were observed for any disease. Both the leukemia and lung cancer results were examined and determined to reflect regional mortality patterns. However, the Non-Hodgkin's Lymphoma finding suggests a curious amplification when living cases are included with the mortality experience. Further examination is recommended of this recurrent finding from all three U.S. Gaseous Diffusion plants.

  14. Experiment Simulation Configurations Used in DUNE CDR

    Energy Technology Data Exchange (ETDEWEB)

    Alion, T. [Univ. of South Carolina, Columbia, SC (United States); Black, J. J. [Univ. of Warwick, Coventry (United Kingdom); Bashyal, A. [Oregon State Univ., Corvallis, OR (United States); Bass, M. [Univ. of Oxford (United Kingdom); Bishai, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Cherdack, D. [Colorado State Univ., Fort Collins, CO (United States); Diwan, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Djurcic, Z. [Argonne National Lab. (ANL), Argonne, IL (United States); Evans, J. [Univ. of Manchester (United Kingdom); Fernandez-Martinez, E. [Madrid Autonama Univ. (Spain); Fields, L. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Fleming, B. [Yale Univ., New Haven, CT (United States); Gran, R. [Univ. of Minnesota, Duluth, MN (United States); Guenette, R. [Univ. of Oxford (United Kingdom); Hewes, J. [Univ. of Manchester (United Kingdom); Hogan, M. [Colorado State Univ., Fort Collins, CO (United States); Hylen, J. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Junk, T. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Kohn, S. [Univ. of California, Berkeley, CA (United States); LeBrun, P. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Lundberg, B. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Marchionni, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Morris, C. [Univ. of California, Berkeley, CA (United States); Papadimitriou, V. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Rameika, R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Rucinski, R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Soldner-Rembold, S. [Univ. of Manchester (United Kingdom); Sorel, M. [Spanish National Research Council (CSIC), Valencia (Spain). Univ. of Valencia (UV), Inst. de Fisica Corpuscular; Urheim, J. [Indiana Univ., Bloomington, IN (United States); Viren, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Whitehead, L. [Univ. of Houston, TX (United States); Wilson, R. [Colorado State Univ., Fort Collins, CO (United States); Worcester, E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Zeller, G. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2016-06-30

    The LBNF/DUNE CDR describes the proposed physics program and experimental design at the conceptual design phase. Volume 2, entitled The Physics Program for DUNE at LBNF, outlines the scientific objectives and describes the physics studies that the DUNE collaboration will perform to address these objectives. The long-baseline physics sensitivity calculations presented in the DUNE CDR rely upon simulation of the neutrino beam line, simulation of neutrino interactions in the far detector, and a parameterized analysis of detector performance and systematic uncertainty. The purpose of this posting is to provide the results of these simulations to the community to facilitate phenomenological studies of long-baseline oscillation at LBNF/DUNE. Additionally, this posting includes GDML of the DUNE single-phase far detector for use in simulations. DUNE welcomes those interested in performing this work as members of the collaboration, but also recognizes the benefit of making these configurations readily available to the wider community.

  15. XML Schema Guide for Primary CDR Submissions

    Science.gov (United States)

    This document presents the extensible markup language (XML) schema guide for the Office of Pollution Prevention and Toxics’ (OPPT) e-CDRweb tool. E-CDRweb is the electronic, web-based tool provided by Environmental Protection Agency (EPA) for the submission of Chemical Data Reporting (CDR) information. This document provides the user with tips and guidance on correctly using the version 1.7 XML schema. Please note that the order of the elements must match the schema.

  16. Safety analysis report on the ''Paducah Tiger'' protective overpack for 10-ton cylinders of uranium hexafluoride. Supplement 1

    International Nuclear Information System (INIS)

    Stitt, D.H.

    1977-01-01

    This supplement details design changes made to the ''Paducah Tiger'' since the issue date of the SAR, June 16, 1976. A 3 / 8 -inch thick, 304L stainless steel plate has been added on the valve end of existing and future overpacks to provide increased puncture resistance and the overpack cavity has been modified to preclude incorrect loading of the type 48X cylinder. Temperature profiles of the ''Paducah Tiger'' during the 30-minute fire test are included

  17. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    Herrmann TR, Georgiou A, Bach T, Gross AJ,. Oelke M. Laser treatments of the prostate vs. TURP/ open prostatectomy: systematic review of urodynamic data. Minerva Urol Nefrol. 2009. Sep; 61(3):309-24. 13. Hoffman RM, Monga M, Elliot SP, Macdonald R,. Wilt TJ. Microwave thermotherapy for benign prostatic hyperplasia ...

  18. The CLIC ILD CDR Geometry for the CDR Monte Carlo Mass Production

    CERN Document Server

    Muennich, A

    2012-01-01

    The CLIC ILD CDR detector for the Monte Carlo event simulation is described in a GEANT4 application, with some parameters available in a database and XML files. This makes it difficult to quickly “look up” interesting parameters of the detector geometry used for the simulation. This note summarises the important geometrical parameters and some details of the implemented detector components.

  19. Cover Final May.cdr

    Indian Academy of Sciences (India)

    user

    475. Classics. On tthe System and Engineering Design of the. General Purpose Electronic Digital Computer at. TIFR. R Narasimhan. 490. 440 Arithmetic and Cryptography. Michel Waldschmidt. FEATURE ARTICLES. 456 Molecule Matters. N-Heterocyclic Carbenes – The Stable Form of R2C: Anil J Elias. BOOK REVIEWS.

  20. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    treatment of hyperparathyroidism and the remaining 9 cases diagnosed during the management of thyroid disorders or cervical nodules . These authors have therefore suggested that the old dictum stating that lateral aberrant thyroid represents metastatic cancer should be either modified or removed in review texts and.

  1. Dose Modeling Evaluations and Technical Support Document for the Authorized Limits Request for the C-746-U Landfill at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Boerner, A. J. [IEAVP, ORISE, Oak Ridge, TN (United States); Maldonado, D. G. [IEAVP, ORISE, Oak Ridge, TN (United States; Hansen, Tom [Ameriphysics, LLC (United States)

    2012-06-01

    This report contains the technical basis in support of the DOE?s derivation of Authorized Limits (ALs) for the DOE Paducah C-746-U Landfill. A complete description of the methodology, including an assessment of the input parameters, model inputs, and results is provided in this report. This report also provides initial recommendations on applying the derived soil guidelines. The ORISE-derived soil guidelines are specifically applicable to the Landfill at the end of its operational life. A suggested 'upper bound' multiple of the derived soil guidelines for individual shipments is provided.

  2. Dose Modeling Evaluations and Technical Support Document for the Authorized Limits Request for the C-746-U Landfill at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    Boerner, A. J.; Maldonado, D. G.; Hansen, Tom

    2012-01-01

    This report contains the technical basis in support of the DOE's derivation of Authorized Limits (ALs) for the DOE Paducah C-746-U Landfill. A complete description of the methodology, including an assessment of the input parameters, model inputs, and results is provided in this report. This report also provides initial recommendations on applying the derived soil guidelines. The ORISE-derived soil guidelines are specifically applicable to the Landfill at the end of its operational life. A suggested 'upper bound' multiple of the derived soil guidelines for individual shipments is provided

  3. Paducah Gaseous Diffusion Plant Annual Site Environmental Report summary for 1993

    International Nuclear Information System (INIS)

    1994-11-01

    This report contains summaries of the environmental programs at Paducah Gaseous Diffusion Plant, environmental monitoring and the results, and the impact of operations on the environment and the public for 1993. The environmental monitoring program at Paducah includes effluent monitoring and environmental surveillance. Effluent monitoring is measurement of releases as they occur. Contaminants are released through either airborne emissions or liquids discharged from the plant. These releases occur as part of normal site operations, such as cooling water discharged from the uranium enrichment cascade operations or airborne releases from ventilation systems. In the event of system failure, this monitoring provides timely warning so that corrective action can be taken before releases reach an unsafe level. Environmental surveillance tracks the dispersion of materials into the environment after they have been released. This involves the collection of samples from various media, such as water, soil, vegetation, and food crops, and the analysis of these samples for certain radionuclides, chemicals, and metals

  4. Environmental Restoration Site-Specific Plan for the Paducah Gaseous Diffusion Plant, FY 93

    International Nuclear Information System (INIS)

    1993-01-01

    This report provides an overview of the major Environmental Restoration (ER) concerns at Paducah Gaseous Diffusion Plant (PGDP). The identified solid waste management units at PGDP are listed. In the Department of Energy (DOE) Five Year Plan development process, one or more waste management units are addressed in a series of activity data sheets (ADSs) which identify planned scope, schedule, and cost objectives that are representative of the current state of planned technical development for individual or multiple sites

  5. XML Schema Guide for Secondary CDR Submissions

    Science.gov (United States)

    This document presents the extensible markup language (XML) schema guide for the Office of Pollution Prevention and Toxics’ (OPPT) e-CDRweb tool. E-CDRweb is the electronic, web-based tool provided by Environmental Protection Agency (EPA) for the submission of Chemical Data Reporting (CDR) information. This document provides the user with tips and guidance on correctly using the version 1.1 XML schema for the Joint Submission Form. Please note that the order of the elements must match the schema.

  6. Dual wall reverse circulation drilling with multi-level groundwater sampling for groundwater contaminant plume delineation at Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    Smuin, D.R.; Morti, E.E.; Zutman, J.L.; Pickering, D.A.

    1995-01-01

    Dual wall reverse circulation (DWRC) drilling was used to drill 48 borings during a groundwater contaminant investigation at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky. This method was selected as an alternative to conventional hollow stem auger drilling for a number of reasons, including the expectation of minimizing waste, increasing the drilling rate, and reducing the potential for cross contamination of aquifers. Groundwater samples were collected from several water-bearing zones during drilling of each borehole. The samples were analyzed for volatile organic compounds using a field gas chromatograph. This approach allowed the investigation to be directed using near-real-time data. Use of downhole geophysical logging, in conjunction with lithologic descriptions of borehole cuttings, resulted in excellent correlation of the geology in the vicinity of the contaminant plume. The total volume of cuttings generated using the DWRC drilling method was less than half of what would have been produced by hollow stem augering; however, the cuttings were recovered in slurry form and had to be dewatered prior to disposal. The drilling rate was very rapid, often approaching 10 ft/min; however, frequent breaks to perform groundwater sampling resulted in an average drilling rate of < 1 ft/min. The time required for groundwater sampling could be shortened by changing the sampling methodology. Analytical results indicated that the drilling method successfully isolated the various water bearing zones and no cross contamination resulted from the investigation

  7. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) {sup 99}Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD.

  8. Dose Modeling Evaluations and Technical Support Document For the Authorized Limits Request for the DOE-Owned Property Outside the Limited Area, Paducah Gaseous Diffusion Plant Paducah, Kentucky

    International Nuclear Information System (INIS)

    Boerner, A. J.

    2012-01-01

    Environmental assessments and remediation activities are being conducted by the U.S. Department of Energy (DOE) at the Paducah Gaseous Diffusion Plant (PGDP), Paducah, Kentucky. The Oak Ridge Institute for Science and Education (ORISE), a DOE prime contractor, was contracted by the DOE Portsmouth/Paducah Project Office (DOE-PPPO) to conduct radiation dose modeling analyses and derive single radionuclide soil guidelines (soil guidelines) in support of the derivation of Authorized Limits (ALs) for 'DOE-Owned Property Outside the Limited Area' ('Property') at the PGDP. The ORISE evaluation specifically included the area identified by DOE restricted area postings (public use access restrictions) and areas licensed by DOE to the West Kentucky Wildlife Management Area (WKWMA). The licensed areas are available without restriction to the general public for a variety of (primarily) recreational uses. Relevant receptors impacting current and reasonably anticipated future use activities were evaluated. In support of soil guideline derivation, a Conceptual Site Model (CSM) was developed. The CSM listed radiation and contamination sources, release mechanisms, transport media, representative exposure pathways from residual radioactivity, and a total of three receptors (under present and future use scenarios). Plausible receptors included a Resident Farmer, Recreational User, and Wildlife Worker. single radionuclide soil guidelines (outputs specified by the software modeling code) were generated for three receptors and thirteen targeted radionuclides. These soil guidelines were based on satisfying the project dose constraints. For comparison, soil guidelines applicable to the basic radiation public dose limit of 100 mrem/yr were generated. Single radionuclide soil guidelines from the most limiting (restrictive) receptor based on a target dose constraint of 25 mrem/yr were then rounded and identified as the derived soil guidelines. An additional evaluation using the derived soil

  9. Dose Modeling Evaluations and Technical Support Document For the Authorized Limits Request for the DOE-Owned Property Outside the Limited Area, Paducah Gaseous Diffusion Plant Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Boerner, A. J. [Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States). Independent Environmental Assessment and Verification Program; Maldonado, D. G. [Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States). Independent Environmental Assessment and Verification Program; Hansen, Tom [Ameriphysics, LLC (United States)

    2012-09-01

    Environmental assessments and remediation activities are being conducted by the U.S. Department of Energy (DOE) at the Paducah Gaseous Diffusion Plant (PGDP), Paducah, Kentucky. The Oak Ridge Institute for Science and Education (ORISE), a DOE prime contractor, was contracted by the DOE Portsmouth/Paducah Project Office (DOE-PPPO) to conduct radiation dose modeling analyses and derive single radionuclide soil guidelines (soil guidelines) in support of the derivation of Authorized Limits (ALs) for 'DOE-Owned Property Outside the Limited Area' ('Property') at the PGDP. The ORISE evaluation specifically included the area identified by DOE restricted area postings (public use access restrictions) and areas licensed by DOE to the West Kentucky Wildlife Management Area (WKWMA). The licensed areas are available without restriction to the general public for a variety of (primarily) recreational uses. Relevant receptors impacting current and reasonably anticipated future use activities were evaluated. In support of soil guideline derivation, a Conceptual Site Model (CSM) was developed. The CSM listed radiation and contamination sources, release mechanisms, transport media, representative exposure pathways from residual radioactivity, and a total of three receptors (under present and future use scenarios). Plausible receptors included a Resident Farmer, Recreational User, and Wildlife Worker. single radionuclide soil guidelines (outputs specified by the software modeling code) were generated for three receptors and thirteen targeted radionuclides. These soil guidelines were based on satisfying the project dose constraints. For comparison, soil guidelines applicable to the basic radiation public dose limit of 100 mrem/yr were generated. Single radionuclide soil guidelines from the most limiting (restrictive) receptor based on a target dose constraint of 25 mrem/yr were then rounded and identified as the derived soil guidelines. An additional evaluation using the derived soil

  10. Antifungal effect of Echinophora platyloba on expression of CDR1 and CDR2 genes in fluconazole-resistant Candida albicans.

    Science.gov (United States)

    Khajeh, Elias; Hosseini Shokouh, Seyed Javad; Rajabibazl, Masoumeh; Roudbary, Maryam; Rafiei, Sajad; Aslani, Peyman; Farahnejad, Zohreh

    2016-01-01

    Several studies examined the effect of the Echinophora platyloba extract in treatment of azole-resistant Candida albicans clinical isolates. We investigated the effect of E. platyloba extract on expression of CDR1 and CDR2 genes in fluconazole-resistant clinical isolates of C. albicans using real-time PCR. The crude extract of E. platyloba was obtained using percolation method. Using serial dilution method, different concentrations of extract were achieved. Two hundred microlitres of fungal suspension (10(6) CFU/ml) was added to the media and cultured with different concentrations and then incubated at 37 °C for 48 h. The concentration of extract in the first tube, which inhibited the growth of C. albicans, was recorded as the Minimal Inhibitory Concentration (MIC). In order to analyse the expression of CDR1 and CDR2 genes, RNA was extracted from C. albicans isolates before and after treatment with MIC of E. platyloba using glass beads and the denaturing buffer agents in an RNase-free environment and then the cDNA was synthesised and used for real-time PCR assay. Twenty of total of 148 isolates were resistant to fluconazole. The MIC and MFC for the alcoholic extract of E. Platyloba were 64 mg/ml and 128 mg/ml, respectively. Real-time PCR results revealed that the mRNA levels of CDR1 and CDR2 genes significantly declined after incubation with E. Platyloba (both p values Candida species.

  11. NOAA Climate Data Record (CDR) of AVHRR Polar Pathfinder (APP) Cryosphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) contains the AVHRR Polar Pathfinder (APP) product. APP is a fundamental CDR comprised of calibrated and navigated AVHRR channel...

  12. An in situ survey of the Paducah Gaseous Diffusion Plant and surrounding area

    International Nuclear Information System (INIS)

    Hoover, R.A.

    1994-02-01

    An in situ survey of the area surrounding the Paducah Gaseous Diffusion Plant was conducted between May 17 and 24, 1990. The survey consisted of in situ measurements and of ground sampling. A High Purity Germanium detector was used for the in situ measurements. The ground samples were taken to the, laboratory at EG ampersand G Energy Measurements, Inc., in Santa Barbara, California, for a radionuclide assay on a laboratory system. Results of the in situ measurements found evidence of naturally occurring radioisotopes, cesium-137 from international fallout, and some evidence of anomalous uranium-238. The soil sampling results show only the presence of naturally occurring radioisotopes, cesium-137, and also anomalous uranium-238

  13. Safety analysis report on the ''Paducah Tiger'' overpack for 10-ton cylinder of uranium hexafluoride

    International Nuclear Information System (INIS)

    Stitt, D.H.

    1978-01-01

    A summary of analysis performed to assess the puncture resistance of the Paducah Tiger under a particularly severe (worst case) orientation of the external puncture pin is presented. The six-inch diameter cylindrical puncture pin has been oriented to place its impact location immediately opposite the valve body mounted to the dished head of the uranium hexafluoride cylinder. The valve body is assumed to have a one-inch clearance relative to the inner wall of the overpack. Analysis indicates that significant residual kinetic energy remains in the system at the instant of overpack inner wall contact with the valve body. Thus, there is strong evidence suggesting that the valve body can be damaged, or sheared from the dished head of the UF 6 , under the assumed worst case impact orientation

  14. Report on the Biological Monitoring Program at Paducah Gaseous Diffusion Plant December 1992--December 1993

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.; Hinzman, R.L.; Peterson, M.J.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1995-06-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). The goals of BMP are to demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, characterize potential health and environmental impacts, document the effects of pollution abatement facilities on stream biota, and recommend any program improvements that would increase effluent treatability. The BMP for PGDP consists of three major tasks: effluent and ambient toxicity monitoring, bioaccumulation studies, and ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report includes ESD activities occurring from December 1992 to December 1993, although activities conducted outside this time period are included as appropriate.

  15. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1990 to November 1992

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A. [ed.

    1994-03-01

    On September 23, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Lab (ORNL) added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in identifying those effluents with the potential for adversely affecting instream fauna, assessing the ecological health of receiving streams, guiding plans for remediation, and protecting human health. In September 1992, a renewed permit was issued which requires toxicity monitoring of continuous and intermittent outfalls on a quarterly basis. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities. This report includes ESD/ORNL activities occurring from December 1990 to November 1992.

  16. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1990 to November 1992

    International Nuclear Information System (INIS)

    Kszos, L.A.

    1994-03-01

    On September 23, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Lab (ORNL) added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in identifying those effluents with the potential for adversely affecting instream fauna, assessing the ecological health of receiving streams, guiding plans for remediation, and protecting human health. In September 1992, a renewed permit was issued which requires toxicity monitoring of continuous and intermittent outfalls on a quarterly basis. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities. This report includes ESD/ORNL activities occurring from December 1990 to November 1992

  17. Impacts from PCB accumulation on amphibians inhabiting streams flowing from the Paducah Gaseous Diffusion Plant.

    Science.gov (United States)

    DeGarady, C J; Halbrook, R S

    2003-11-01

    Contamination at the Paducah Gaseous Diffusion Plant (PGDP), Paducah, Kentucky, has been under evaluation for many years. We studied amphibians in selected outfalls (drainage ditches) flowing from the PGDP to determine if PCBs were accumulating in their tissues and how this might affect local populations. We determined relative amphibian species richness and abundance among seven outfalls and three reference streams by listening to their calls during audio surveys. We also captured amphibians from each study site during the summers of 2000 and 2001 and analyzed their carcasses for PCBs (Aroclor 1260 and 34 congeners) and livers for ethoxyresorufin O-deethylase (EROD) activity, a biomarker of PCBs and other organic contamination. Ten species were heard across study sites, and abundance and richness at outfalls were similar to those observed at reference sites. However, there were significant differences in abundance (p = 0.001) and richness (p = 0.048) of amphibians between continuously flowing and intermittent outfalls. There were no significant differences in PCB concentrations (p = 0.113) in amphibians captured from study sites, although Aroclor 1260 concentrations tended to be higher in amphibians collected from one outfall (outfall 12) on the east side of the plant (x = 1260 microg/kg) compared with all other study sites (x = 489 microg/kg). EROD activity measured in the liver was not indicative of Aroclor 1260 concentrations in amphibians at the PGDP, and EROD did not differ by study site, species, age class, or gender. PCB concentrations measured in amphibians at the PGDP were similar to concentrations measured at reference sites and did not appear to negatively affect individual amphibians or abundance and richness.

  18. Bedrock geology of the Paducah 1 degree x 2 degrees CUSMAP quadrangle, Illinois, Indiana, Kentucky, and Missouri

    Science.gov (United States)

    Nelson, W. John

    1998-01-01

    The Paducah 1? by 2? quadrangle (hereafter referred to as the Paducah quadrangle) encompasses the eastern flank of the Ozark dome, the southern end of the Illinois Basin, and the northern end of the Mississippi Embayment. Resting on Proterozoic basement, sedimentary rocks of Cambrian through Permian age in the Illinois Basin and Ozark dome are overlapped by weakly lithified Cretaceous, Paleocene, Eocene, and Pliocene strata in the embayment. This is one of the most intensely faulted areas of the North American Midcontinent. A Proterozoic crustal terrane boundary (coincident with part of the Ste. Genevieve fault zone) and a failed intracratonic rift (Reelfoot rift and Rough Creek graben) have been reactivated repeatedly under various stress fields from Proterozoic through late Tertiary times. ? ' 2 ? quadrangle (hereafter referred to as the Paducah quadrangle) encompasses the eastern flank of the Ozark dome, the southern end of the Illinois Basin, and the northern end of the Mississippi Embayment. Resting on Proterozoic basement, sedimentary rocks of Cambrian through Permian age in the Illinois Basin and Ozark dome are overlapped by weakly lithified Cretaceous, Paleocene, Eocene, and Pliocene strata in the embayment. This is one of the most intensely faulted areas of the North American Midcontinent. A Proterozoic crustal terrane boundary (coincident with part of the Ste. Genevieve fault zone) and a failed intracratonic rift (Reelfoot rift and Rough Creek graben) have been reactivated repeatedly under various stress fields from Proterozoic through late Tertiary times.

  19. CLICdet: The post-CDR CLIC detector model

    CERN Document Server

    Alipour Tehrani, Niloufar; Cure, Benoit; Dannheim, Dominik; Duarte Ramos, Fernando; Elsener, Konrad; Gaddi, Andrea; Gerwig, Hubert; Green, Steven; Grefe, Christian; Hynds, Daniel; Klempt, Wolfgang; Linssen, Lucie; Nikiforou, Nikiforos; Nurnberg, Andreas Matthias; Marshall, John Stuart; Petric, Marko; Redford, Sophie; Roloff, Philipp Gerhard; Sailer, Andre; Sefkow, Felix; Sicking, Eva; Siegrist, Nicolas; Simon, Frank Richard; Simoniello, Rosa; Spannagel, Simon; Sroka, Szymon Krzysztof; Strom, Lars Rickard; Weber, Matthias Artur

    2017-01-01

    A new model for the CLIC detector has been defined based on lessons learnt while working with the CDR detector models and after a series of simulation studies. The new model, dubbed "CLICdet", also incorporates the experience from various R&D activities linked to a future experiment at CLIC. This note describes the studies and thoughts leading to the new detector model, and gives details on all of its sub-detector systems.

  20. MJZ VOL 37 NO 2.CDR

    African Journals Online (AJOL)

    MJZ

    study type of the research published as the dissertations for the M.Med at the University of. Zambia. METHODS. We conducted a desk review of dissertations of graduates of the Master of Medicine programme at the University of Zambia. This consisted of a review of dissertations deposited in the special collections of the ...

  1. A Technical Assessment Of The Current Water Policy Boundary At U.S. Department Of Energy, Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    None

    2012-01-01

    In 1988, groundwater contaminated with trichloroethene (TCE) and technetium-99 (Tc-99) was identified in samples collected from residential water wells withdrawing groundwater from the Regional Gravel Aquifer (RGA) north of the Paducah Gaseous Diffusion Plant (PGDP) facility. In response, the U.S. Department of Energy (DOE) provided temporary drinking water supplies to approximately 100 potentially affected residents by initially supplying bottled water, water tanks, and water-treatment systems, and then by extending municipal water lines, all at no cost, to those persons whose wells could be affected by contaminated groundwater. The Water Policy boundary was established in 1993. In the Policy, DOE agreed to pay the reasonable monthly cost of water for homes and businesses and, in exchange, many of the land owners signed license agreements committing to cease using the groundwater via rural water wells. In 2012, DOE requested that Oak Ridge Associated Universities (ORAU), managing contractor of Oak Ridge Institute for Science and Education (ORISE), provide an independent assessment of the quality and quantity of the existing groundwater monitoring data and determine if there is sufficient information to support a modification to the boundary of the current Water Policy. As a result of the assessment, ORAU concludes that sufficient groundwater monitoring data exists to determine that a shrinkage and/or shift of the plume(s) responsible for the initial development of this policy has occurred. Specifically, there is compelling evidence that the TCE plume is undergoing shrinkage due to natural attenuation and associated degradation. The plume shrinkage (and migration) has also been augmented in local areas where large volumes of groundwater were recovered by pump-and treat remedial systems along the eastern and western boundaries of the Northwest Plume, and in other areas where pump-and-treat systems have been deployed by DOE to remove source contaminants. The

  2. A TECHNICAL ASSESSMENT OF THE CURRENT WATER POLICY BOUNDARY AT U.S. DEPARTMENT OF ENERGY, PADUCAH GASEOUS DIFFUSION PLANT, PADUCAH, KENTUCKY

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-12-13

    In 1988, groundwater contaminated with trichloroethene (TCE) and technetium-99 (Tc-99) was identified in samples collected from residential water wells withdrawing groundwater from the Regional Gravel Aquifer (RGA) north of the Paducah Gaseous Diffusion Plant (PGDP) facility. In response, the U.S. Department of Energy (DOE) provided temporary drinking water supplies to approximately 100 potentially affected residents by initially supplying bottled water, water tanks, and water-treatment systems, and then by extending municipal water lines, all at no cost, to those persons whose wells could be affected by contaminated groundwater. The Water Policy boundary was established in 1993. In the Policy, DOE agreed to pay the reasonable monthly cost of water for homes and businesses and, in exchange, many of the land owners signed license agreements committing to cease using the groundwater via rural water wells. In 2012, DOE requested that Oak Ridge Associated Universities (ORAU), managing contractor of Oak Ridge Institute for Science and Education (ORISE), provide an independent assessment of the quality and quantity of the existing groundwater monitoring data and determine if there is sufficient information to support a modification to the boundary of the current Water Policy. As a result of the assessment, ORAU concludes that sufficient groundwater monitoring data exists to determine that a shrinkage and/or shift of the plume(s) responsible for the initial development of this policy has occurred. Specifically, there is compelling evidence that the TCE plume is undergoing shrinkage due to natural attenuation and associated degradation. The plume shrinkage (and migration) has also been augmented in local areas where large volumes of groundwater were recovered by pump-and treat remedial systems along the eastern and western boundaries of the Northwest Plume, and in other areas where pump-and-treat systems have been deployed by DOE to remove source contaminants. The

  3. Determination of operating limits for radionuclides for a proposed landfill at Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Wang, J.C.; Lee, D.W.; Ketelle, R.H.; Lee, R.R.; Kocher, D.C.

    1994-01-01

    The operating limits for radionuclides in sanitary and industrial wastes were determined for a proposed landfill at the Paducah Gaseous Diffusion Plant (PGDP), Kentucky. These limits, which may be very small but nonzero, are not mandated by law or regulation but are needed for rational operation. The approach was based on analyses of the potential contamination of groundwater at the plant boundary and the potential exposure to radioactivity of an intruder at the landfill after closure. The groundwater analysis includes (1) a source model describing the disposal of waste and the release of radionuclides from waste to the groundwater, (2) site-specific groundwater flow and contaminant transport calculations, and (3) calculations of operating limits from the dose limit and conversion factors. The intruder analysis includes pathways through ingestion of contaminated vegetables and soil, external exposure to contaminated soil, and inhalation of suspended activity from contaminated soil particles. In both analyses, a limit on annual effective dose equivalent of 4 mrem (0.04 mSv) was adopted. The intended application of the results is to refine the radiological monitoring standards employed by the PGDP Health Physics personnel to determine what constitutes radioactive wastes, with concurrence of the Commonwealth of Kentucky

  4. Strong motion modeling at the Paducah Diffusion Facility for a large New Madrid earthquake

    International Nuclear Information System (INIS)

    Herrmann, R.B.

    1991-01-01

    The Paducah Diffusion Facility is within 80 kilometers of the location of the very large New Madrid earthquakes which occurred during the winter of 1811-1812. Because of their size, seismic moment of 2.0 x 10 27 dyne-cm or moment magnitude M w = 7.5, the possible recurrence of these earthquakes is a major element in the assessment of seismic hazard at the facility. Probabilistic hazard analysis can provide uniform hazard response spectra estimates for structure evaluation, but a deterministic modeling of a such a large earthquake can provide strong constraints on the expected duration of motion. The large earthquake is modeled by specifying the earthquake fault and its orientation with respect to the site, and by specifying the rupture process. Synthetic time histories, based on forward modeling of the wavefield, from each subelement are combined to yield a three component time history at the site. Various simulations are performed to sufficiently exercise possible spatial and temporal distributions of energy release on the fault. Preliminary results demonstrate the sensitivity of the method to various assumptions, and also indicate strongly that the total duration of ground motion at the site is controlled primarily by the length of the rupture process on the fault

  5. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January--December 1997

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.; Peterson, M.J.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1998-03-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). A plan for the biological monitoring of the receiving streams was implemented in 1987 and consisted of ecological surveys, toxicity monitoring of effluents and receiving streams, evaluation of bioaccumulation of trace contaminants in biota, and supplemental chemical characterization of effluents. Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in (1) identifying those effluents with the potential for adversely affecting instream fauna, (2) assessing the ecological health of receiving streams, and (3) guiding plans for remediation and protecting human health. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of benthic macroinvertebrate communities and fish. With the exception of the benthic macroinvertebrate community surveys, this report focuses on activities from January to December 1997.

  6. Report on the Watershed Monitoring Program at the Paducah Site January-December 1998

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.; Peterson, M.J.; Ryon, M.G.; Southworth, G.R.

    1999-03-01

    Watershed Monitoring of Big Bayou and Little Bayou creeks has been conducted since 1987. The monitoring was conducted by the University of Kentucky between 1987 and 1991 and by staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) from 1991 to present. The goals of monitoring are to (1) demonstrate that the effluent limitations established for DOE protect and maintain the use of Little Bayour and Big Bayou creeks for frowth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, and (3) document the effects of pollution abatement facilities on stream biota. The watershed (biological) monitoring discussed in this report was conducted under DOE Order 5400.1, General Environmental Protection Program. Future monitoring will be conducted as required by the Kentucky Pollutant Discharge Elimination System (KPDES) permit issued to the Department of Energy (DOE) in March 1998. A draft Watershed Monitoring Program plan was approved by the Kentucky Division of Water and will be finalized in 1999. The DOE permit also requires toxicity monitoring of one continuous outfall and of three intermittent outfalls on a quarterly basis. The Watershed Monitoring Program for the Paducah Site during calendar year 1998 consisted of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of fish communities. This report focuses on ESD activities occurring from january 1998 to December 1998, although activities conducted outside this time period are included as appropriate.

  7. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January-December 1997

    International Nuclear Information System (INIS)

    Kszos, L.A.; Peterson, M.J.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1998-03-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). A plan for the biological monitoring of the receiving streams was implemented in 1987 and consisted of ecological surveys, toxicity monitoring of effluents and receiving streams, evaluation of bioaccumulation of trace contaminants in biota, and supplemental chemical characterization of effluents. Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in (1) identifying those effluents with the potential for adversely affecting instream fauna, (2) assessing the ecological health of receiving streams, and (3) guiding plans for remediation and protecting human health. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of benthic macroinvertebrate communities and fish. With the exception of the benthic macroinvertebrate community surveys, this report focuses on activities from January to December 1997

  8. Martin Marietta Paducah Gaseous Diffusion Plant comprehensive earthquake emergency management program

    International Nuclear Information System (INIS)

    1990-01-01

    Recognizing the value of a proactive, integrated approach to earthquake preparedness planning, Martin Marietta Energy Systems, Inc. initiated a contract in June 1989 with Murray State University, Murray, Kentucky, to develop a comprehensive earthquake management program for their Gaseous Diffusion Plant in Paducah, Kentucky (PGDP -- Subcontract No. 19P-JV649V). The overall purpose of the program is to mitigate the loss of life and property in the event of a major destructive earthquake. The program includes four distinct (yet integrated) components: (1) an emergency management plan with emphasis on the catas trophic earthquake; (2) an Emergency Operations Center Duty Roster Manual; (3) an Integrated Automated Emergency Management Information System (IAEMIS); and (4) a series of five training program modules. The PLAN itself is comprised of four separate volumes: Volume I -- Chapters 1--3; Volume II -- Chapters 4--6; Volume III -- Chapter 7; and Volume IV -- 23 Appendices. The EOC Manual (which includes 15 mutual aid agreements) is designated as Chapter 7 in the PLAN and is this document numbered as Volume III

  9. Martin Marietta Paducah Gaseous Diffusion Plant comprehensive earthquake emergency management program

    International Nuclear Information System (INIS)

    1990-01-01

    Recognizing the value of a proactive, integrated approach to earthquake preparedness planning, Martin Marietta Energy Systems, Inc. initiated a contract in June 1989 with Murray State University, Murray, Kentucky, to develop a comprehensive earthquake management program for their Gaseous Diffusion Plant in Paducah, Kentucky (PGDP -- Subcontract No. 19P-JV649V). The overall purpose of the program is to mitigate the loss of life and property in the event of a major destructive earthquake. The program includes four distinct (yet integrated) components: an emergency management plan, with emphasis on the catastrophic earthquake; an Emergency Operations Center Duty Roster Manual; an Integrated Automated Emergency Management Information System (IAEMIS); and a series of five training program modules. The PLAN itself is comprised of four separate volumes: Volume I -- Chapters 1--3; Volume II -- Chapters 4--6, Volume III -- Chapter 7, and Volume IV -- 23 Appendices. The EOC Manual (which includes 15 mutual aid agreements) is designated as Chapter 7 in the PLAN and is a ''stand alone'' document numbered as Volume III. This document, Volume II, discusses methodology, engineering and environmental analyses, and operational procedures

  10. Martin Marietta Paducah Gaseous Diffusion Plant comprehensive earthquake emergency management program

    International Nuclear Information System (INIS)

    1990-01-01

    Recognizing the value of a proactive, integrated approach to earthquake preparedness planning, Martin Marietta Energy Systems, Inc. initiated a contract in June 1989 with Murray State University, Murray, Kentucky, to develop a comprehensive earthquake management program for their Gaseous Diffusion Plant in Paducah, Kentucky. The overall purpose of the program is to mitigate the loss of life and property in the event of a major destructive earthquake. The program includes four distinct (yet integrated) components: an emergency management plan, with emphasis on the catastrophic earthquake; an Emergency Operations Center Duty Roster Manual; an Integrated Automated Emergency Management Information System (IAEMIS); and a series of five training program modules. The PLAN itself is comprised of four separate volumes: Volume I -- Chapters 1--3; Volume II -- Chapters 4--6, Volume III -- Chapter 7, and Volume IV -- 23 Appendices. The EOC Manual (which includes 15 mutual aid agreements) is designated as Chapter 7 in the PLAN and is a ''stand alone'' document numbered as Volume III. This document, Volume I, provides an introduction, summary and recommendations, and the emergency operations center direction and control

  11. Martin Marietta Paducah Gaseous Diffusion Plant comprehensive earthquake emergency management program

    International Nuclear Information System (INIS)

    1990-01-01

    Recognizing the value of a proactive, integrated approach to earthquake preparedness planning, Martin Marietta Energy Systems, Inc, initiated a contract in June 1989 with Murray State University, Murray, Kentucky, to develop a comprehensive earthquake management program for their Gaseous Diffusion Plant in Paducah, Kentucky (PGDP--Subcontract No. 19P-JV649V). The overall purpose of the program is to mitigate the loss of life and property in the event of a major destructive earthquake. The program includes four distinct (yet integrated) components: (1) an emergency management plan, with emphasis on the catas trophic earthquake, (2) an Emergency Operations Center Duty Roster Manual, (3) an Integrated Automated Emergency Management Information System (IAEMIS), and (4) a series of five training program modules. The PLAN itself is comprised of four separate volumes: Volume I--Chapters 1--3; Volume II--Chapters 4--6, Volume III--Chapter 7, and Volume IV--23 Appendices. The EOC Manual (which includes 15 mutual aid agreements) is designated as Chapter 7 in the PLAN and is a ''stand alone'' document numbered as Volume III. This document, Volume IV contains the appendices to this report

  12. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January - December 1996

    International Nuclear Information System (INIS)

    Kszos, L.A.; Konetsky, B.K.; Peterson, M.J.; Petrie, R.B.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1997-06-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous diffusion Plant (PGDP). The PGDP BMP was conducted by the University of Kentucky Between 1987 and 1992 and by staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) from 1991 to present. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, and (3) document the effects of pollution abatement facilities on stream. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report focuses on ESD activities occurring from January 1996 to December 1996, although activities conducted outside this time period are included as appropriate

  13. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January--December 1996

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A. [ed.; Konetsky, B.K.; Peterson, M.J.; Petrie, R.B.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1997-06-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous diffusion Plant (PGDP). The PGDP BMP was conducted by the University of Kentucky Between 1987 and 1992 and by staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) from 1991 to present. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, and (3) document the effects of pollution abatement facilities on stream. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report focuses on ESD activities occurring from January 1996 to December 1996, although activities conducted outside this time period are included as appropriate.

  14. Operating limit study for the proposed solid waste landfill at Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Lee, D.W.; Wang, J.C.; Kocher, D.C.

    1995-06-01

    A proposed solid waste landfill at Paducah Gaseous Diffusion Plant (PGDP) would accept wastes generated during normal operations that are identified as non-radioactive. These wastes may include small amounts of radioactive material from incidental contamination during plant operations. A site-specific analysis of the new solid waste landfill is presented to determine a proposed operating limit that will allow for waste disposal operations to occur such that protection of public health and the environment from the presence of incidentally contaminated waste materials can be assured. Performance objectives for disposal were defined from existing regulatory guidance to establish reasonable dose limits for protection of public health and the environment. Waste concentration limits were determined consistent with these performance objectives for the protection of off-site individuals and inadvertent intruders who might be directly exposed to disposed wastes. Exposures of off-site individuals were estimated using a conservative, site-specific model of the groundwater transport of contamination from the wastes. Direct intrusion was analyzed using an agricultural homesteader scenario. The most limiting concentrations from direct intrusion or groundwater transport were used to establish the concentration limits for radionuclides likely to be present in PGDP wastes

  15. JMBR VOLUME 14 Number 2.cdr

    African Journals Online (AJOL)

    FINEPRINT

    January 2000 to December 2009) was carried out to define the histopathological pattern of nasopharyngeal carcinoma (NPC) in Nigerian patients in Edo state. Parameters included in the review where histological types of NPC according to.

  16. 16nov Sadhana broch prn.cdr

    Indian Academy of Sciences (India)

    sadh/). SADHANA. ACADEMY PROCEEDINGS IN. ENGINEERING. SCIENCES ... collection. Print subscriptions within India and open online access are served from Indian Academy of Sciences. Peer review system. ISSN 0256-2499 (print). elSSN.

  17. NOAA Climate Data Record (CDR) of Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN-CDR), Version 1 Revision 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — PERSIANN Precipitation Climate Data Record (PERSIANN-CDR) is a daily quasi-global precipitation product for the period of 1982 to 2011. The data covers from 60...

  18. IJS v10 n1.cdr

    African Journals Online (AJOL)

    De Don

    sector, ... being a major role player in the West African sub- region and a front liner in Africa needs a virile and ... Oluwadare and Kayode: Binary logistic regression model for electronic banking in Akure. 4. Literature Review. Historical evolution of ...

  19. DECEMBER JMBR 13 - 2 correction.cdr

    African Journals Online (AJOL)

    Fine Print

    JMBR: A Peer-review Journal of Biomedical Sciences. December 2014, Vol. 13 No.2 pp 5-15. KEYWORDS: Caffeine, Milk, Lung function. ABSTRACT. Caffeine has been reported to be a respiratory stimulant; there is paucity of literatures relating the effect of ingestion of a mixture of caffeine and milk on lung function. This.

  20. JUNE NJCP 2009 FINAL sp.cdr

    African Journals Online (AJOL)

    User

    Utilizing the case records in the morbid anatomy department of LUTH, cases of histologically confirmed primary bone tumours over the study period were retrieved. They were reviewed and analysed for age, gender and histological types. Tumours of the marrow elements except for Ewing's. 12. MATERIALSANDMETHODS ...

  1. JUNE 2010.for Ogidi (final).cdr

    African Journals Online (AJOL)

    User

    clinical audit, intra-partum care, birth attendants, health facilities, quality ... of the baby at birth. Names were excluded from extracted information in order to ensure confidentiality of individual parturients and health care providers, which a study of this nature required. ... records reviewed was 23.4 ± 3.3 years (Confidence.

  2. TJOG Vol 26 No 2.cdr

    African Journals Online (AJOL)

    histologically confirmed in the period under presented with GTD had no formal education. review giving a ..... London: Hodder. 4. World Health Organisation Scientific Group. Headline Group2001; 231-237. Gestational Trophoblastic Disease 692. Geneva: 2. Howie PW. Trophoblastic disease. In: Edmunds D. World Health ...

  3. The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans.

    Science.gov (United States)

    Shao, Jing; Zhang, MengXiang; Wang, TianMing; Li, Yue; Wang, ChangZhong

    2016-01-01

    Fungal infections caused by fluconazole-resistant Candida albicans are an intractable clinical problem, calling for new efficient antifungal drugs. Kaempferol, an active flavonoid, has been considered a potential candidate against Candida species. This work investigates the resistance reversion of kaempferol in fluconazole-resistant C. albicans and the underlying mechanism. The antifungal activities of fluconazole and/or kaempferol were assessed by a series of standard procedures including broth microdilution method, checkerboard assay and time-kill (T-K) test in nine clinical strains as well as a standard reference isolate of C. albicans. Subsequently, the morphological changes, the efflux of rhodamine 6G, and the expressions of CDR 1, CDR 2, and MDR 1 were analysed by scanning electron microscope (SEM), inverted fluorescence microscope and quantitative reverse transcription polymerase chain reaction (qRT-PCR) in C. albicans z2003. For all the tested C. albicans strains, the minimum inhibitory concentrations (MICs) of fluconazole and kaempferol ranged 0.25-32 and 128-256 μg/mL with a range of fractional inhibitory concentration index of 0.257-0.531. In C. albicans z2003, the expression of both CDR 1 and CDR 2 were decreased after exposure to kaempferol alone with negligible rhodamine 6G accumulation, while the expression of CDR 1, CDR 2 and MDR 1 were all decreased when fluconazole and kaempferol were used concomitantly with notable fluorescence of rhodamine 6G observed. Kaempferol-induced reversion in fluconazole-resistant C. albicans might be likely due to the suppression of the expression of CDR1, CDR2 and MDR1.

  4. Task analysis methods applicable to control room design review (CDR)

    International Nuclear Information System (INIS)

    Moray, N.P.; Senders, J.W.; Rhodes, W.

    1985-06-01

    This report presents the results of a research study conducted in support of the human factors engineering program of the Atomic Energy Control Board in Canada. It contains five products which may be used by the Atomic Enegy Control Board in relation to Task Analysis of jobs in CANDU nuclear power plants: 1. a detailed method for preparing for a task analysis; 2. a Task Data Form for recording task analysis data; 3. a detailed method for carrying out task analyses; 4. a guide to assessing alternative methods for performing task analyses, if such are proposed by utilities or consultants; and 5. an annotated bibliography on task analysis. In addition, a short explanation of the origins, nature and uses of task analysis is provided, with some examples of its cost effectiveness. 35 refs

  5. Cooling tower drift studies at the Paducah, Kentucky Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Taylor, F.G.; Hanna, S.R.; Parr, P.D.

    1979-01-01

    The transfer and fate of chromium from cooling tower drift to terrestrial ecosystems were quantified at the Department of Energy's uranium enrichment facility at Paducah, Kentucky. Chromium concentrations in plant materials (fescue grass) decreased with increasing distance from the cooing tower, ranging from 251 +- 19 ppM at 15 meters to 0.52 +- 0.07 ppM at 1500 meters. The site of drift contamination, size characteristics, and elemental content of drift particles were determined using a scanning electron microscope with energy dispersive x-ray analysis capabilities. Results indicate that elemental content in drift water (mineral residue) may not be equivalent to the content in the recirculating cooling water of the tower. This hypothesis is contrary to basic assumptions in calculating drift emissions. A laboratory study simulating throughfall from 1 to 6 inches of rain suggested that there are more exchange sites associated with litter than live foliage. Leachate from each one inch throughfall simulant removed 3% of the drift mass from litter compared to 7 to 9% from live foliage. Results suggest that differences in retention are related to chemical properties of the drift rather than physical lodging of the particle residue. To determine the potential for movement of drift-derived chromium to surface streams, soil--water samplers (wells) were placed along a distance gradient to Little Bayou Creek. Samples from two depths following rainstorms revealed the absence of vertical or horizontal movement with maximum concentrations of 0.13 ppb at 50 meters from the tower. Preliminary model estimates of drift deposition are compared to depositionmeasurements. Isopleths of the predicted deposition are useful to identify areas of maximum drift transport in the environs of the gaseous diffusion plant

  6. High Performance CDR Processing with MapReduce

    Directory of Open Access Journals (Sweden)

    Mulya Agung

    2016-09-01

    Full Text Available A call detail record (CDR is a data record produced by telecommunication equipment consisting of call detail transaction logs. It contains valuable information for many purposes in several domains, such as billing, fraud detection and analytical purposes. However, in the real world these needs face a big data challenge. Billions of CDRs are generated every day and the processing systems are expected to deliver results in a timely manner. The capacity of our current production system is not enough to meet these needs. Therefore a better performing system based on MapReduce and running on Hadoop cluster was designed and implemented. This paper presents an analysis of the previous system and the design and implementation of the new system, called MS2. In this paper also empirical evidence is provided to demonstrate the efficiency and linearity of MS2. Tests have shown that MS2 reduces overhead by 44% and speeds up performance nearly twice compared to the previous system. From benchmarking with several related technologies in large-scale data processing, MS2 was also shown to perform better in the case of CDR batch processing.  When it runs on a cluster consisting of eight CPU cores and two conventional disks, MS2 is able to process 67,000 CDRs/second.

  7. Ontogeny of the avian intestinal immunoglobulin repertoire: modification in CDR3 length and conserved VH-pseudogene usage.

    Science.gov (United States)

    den Hartog, Gerco; Crooijmans, Richard P M A; Parmentier, Henk K; Savelkoul, Huub F J; Bos, Nicolaas A; Lammers, Aart

    2013-12-01

    Immunoglobulins play an important role in maintenance of mucosal homeostasis in the gut. The antigen binding specificity of these immunoglobulins depends for a large part on the hypervariable CDR3 region. To gain knowledge about isotype-specific development of the CDR3 repertoire we examined CDR3 spectratypes at multiple time points between 4 and 70 days post hatch. In order to identify clonal expansions deviation from the normal distribution (SS) and the average CDR3 length was calculated. IgA-CDR3 regions were studied in more detail by DNA sequence analysis at day 7 and 70 and preferential VH pseudogene usage was estimated. The SS of CDR3 repertoires of the IgM, IgG and IgA isotypes successively increased, but for each isotype this increase was transiently. The length of the CDR3 regions decreased with age for IgM becoming similar to the CDR3 length of IgA at day 70. The IgA- and IgG-CDR3 lengths did not change with age. On average, the CDR3 length of IgA was the shortest. IgA CDR3 sequences were similar between animals aged 7 and 70 days. A limited number of pseudogenes was used, and no differences in pseudogene usage were observed between animals aged 7 and 70 days. Of the identified VH pseudogenes, half of the sequences used VH15, whilst a number of the pseudogenes were not used at all. We conclude that CDR3 spectratype profiles change during aging, whilst at the CDR3-sequence level, variation in VH pseudogene usage for ileal IgA is limited suggesting conservation during ontogeny. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Floodplain/wetland assessment of the effects of construction and operation ofa depleted uranium hexafluoride conversion facility at the Paducah, Kentucky,site.

    Energy Technology Data Exchange (ETDEWEB)

    Van Lonkhuyzen, R.

    2005-09-09

    The U.S. Department of Energy (DOE) Depleted Uranium Hexafluoride (DUF{sub 6}) Management Program evaluated alternatives for managing its inventory of DUF{sub 6} and issued the ''Programmatic Environmental Impact Statement for Alternative Strategies for the Long-Term Management and Use of Depleted Uranium Hexafluoride'' (DUF{sub 6} PEIS) in April 1999 (DOE 1999). The DUF{sub 6} inventory is stored in cylinders at three DOE sites: Paducah, Kentucky; Portsmouth, Ohio; and East Tennessee Technology Park (ETTP), near Oak Ridge, Tennessee. In the Record of Decision for the DUF{sub 6} PEIS, DOE stated its decision to promptly convert the DUF{sub 6} inventory to a more stable chemical form. Subsequently, the U.S. Congress passed, and the President signed, the ''2002 Supplemental Appropriations Act for Further Recovery from and Response to Terrorist Attacks on the United States'' (Public Law No. 107-206). This law stipulated in part that, within 30 days of enactment, DOE must award a contract for the design, construction, and operation of a DUF{sub 6} conversion plant at the Department's Paducah, Kentucky, and Portsmouth, Ohio, sites, and for the shipment of DUF{sub 6} cylinders stored at ETTP to the Portsmouth site for conversion. This floodplain/wetland assessment has been prepared by DOE, pursuant to Executive Order 11988 (''Floodplain Management''), Executive Order 11990 (Protection of Wetlands), and DOE regulations for implementing these Executive Orders as set forth in Title 10, Part 1022, of the ''Code of Federal Regulations'' (10 CFR Part 1022 [''Compliance with Floodplain and Wetland Environmental Review Requirements'']), to evaluate potential impacts to floodplains and wetlands from the construction and operation of a conversion facility at the DOE Paducah site. Reconstruction of the bridge crossing Bayou Creek would occur within the Bayou Creek 100-year

  9. NOAA Climate Data Record (CDR) of Passive Microwave Sea Ice Concentration, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Passive Microwave Sea Ice Concentration Climate Data Record (CDR) dataset is generated using daily gridded brightness temperatures from the Defense...

  10. A 5 Gb/s low area CDR for embedded clock serial links

    Science.gov (United States)

    You, Li; Junsheng, Lü; Yumei, Zhou; Jianzhong, Zhao; Yuhu, Chen; Feng, Zhang

    2015-02-01

    A multi-standard compatible clock and data recovery circuit (CDR) with a programmable equalizer and wide tracking range is presented. Considering the jitter performance, tracking range and chip area, the CDR employs a first-order digital loop filter, two 6-bit DACs and high linearity phase interpolators to achieve high phase resolution and low area. Meanwhile the tracking range is greater than ±2200 ppm, making this proposed CDR suitable for the embedded clock serial links. A test chip was fabricated in the 55 nm CMOS process. The measurements show that the test chip can achieve BER < 10-12 and meet the jitter tolerance specification. The test chip occupies 0.19 mm2 with a 0.0486 mm2 CDR core, which only consumes 30 mW from a 1.2 V supply at 5 Gb/s.

  11. NOAA Climate Data Record (CDR) of Ocean Near Surface Atmospheric Properties, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Ocean Surface Bundle (OSB) Climate Data Record (CDR) consist of three parts: sea surface temperature; near-surface wind speed, air temperature, and specific...

  12. NOAA Climate Data Record (CDR) of Solar Spectral Irradiance (SSI), NRLSSI Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) contains solar spectral irradiance (SSI) as a function of time and wavelength created with the Naval Research Laboratory model for...

  13. NOAA Fundamental Climate Data Record (CDR) of AMSU-B and MHS Brightness Temperature, Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Climate Data Record (CDR) of Advanced Microwave Sounding Unit-B (AMSU-B) and Microwave Humidity Sounder (MHS) brightness temperature (Tb) in "window...

  14. NOAA Climate Data Record (CDR) of Monthly Outgoing Longwave Radiation (OLR), Version 2.2-1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) of monthly mean High Resolution Infrared Radiation Sounder (HIRS) Outgoing Longwave Radiation (OLR) flux at the top of the atmosphere...

  15. NOAA Climate Data Record (CDR) of Daily Outgoing Longwave Radiation (OLR), Version 1.2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) contains the daily mean Outgoing Longwave Radiation (OLR) time series in global 1 degree x 1 degree equal-angle gridded maps spanning...

  16. NOAA Climate Data Record (CDR) of Ocean Heat Fluxes, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Ocean Surface Bundle (OSB) Climate Data Record (CDR) consist of three parts: sea surface temperature; near-surface wind speed, air temperature, and specific...

  17. NOAA Climate Data Record (CDR) of Passive Microwave Sea Ice Concentration, Version 1.0

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset version has been superseded by version 2. This data set provides a Climate Data Record (CDR) of passive microwave sea ice concentration based on the...

  18. NOAA Climate Data Record (CDR) of Atmospheric Layer Temperatures, Version 3.3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Atmospheric Layer Temperature Climate Data Record (CDR) dataset is a monthly analysis of the tropospheric and stratospheric data using temperature sounding...

  19. NOAA Climate Data Record (CDR) of Northern Hemisphere (NH) Snow Cover Extent (SCE), Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) is a record for the Northern Hemisphere (NH) Snow Cover Extent (SCE) spanning from October 4, 1966 to present, updated monthly...

  20. NOAA Climate Data Record (CDR) of Total Solar Irradiance (TSI), NRLTSI Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) contains total solar irradiance (TSI) as a function of time created with the Naval Research Laboratory model for spectral and total...

  1. NOAA Climate Data Record (CDR) of Normalized Difference Vegetation Index (NDVI), Version 4

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains gridded daily Normalized Difference Vegetation Index (NDVI) derived from the NOAA Climate Data Record (CDR) of Advanced Very High Resolution...

  2. NOAA Climate Data Record (CDR) of AVHRR Polar Pathfinder Extended (APP-X) Cryosphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Climate Data Record (CDR) of the extended AVHRR Polar Pathfinder (APP-x) cryosphere contains 19 geophysical variables over the Arctic and Antarctic for the...

  3. Chemicals Reported for the 2012 Chemical Data Reporting (CDR) in Alphabetical Order

    Science.gov (United States)

    For the 2012 CDR, 7,674 unique chemicals were reported by manufacturers (including importers).Chemicals are listed in alphabetical order by CA Index Name (for non-confidential chemicals) or by generic chemical name.

  4. NOAA Climate Data Record (CDR) of Sea Surface Temperature - WHOI, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Ocean Surface Bundle (OSB) Climate Data Record (CDR) consist of three parts: sea surface temperature, near-surface atmospheric properties, and heat fluxes....

  5. Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans

    International Nuclear Information System (INIS)

    Shukla, Suneet; Sauna, Zuben E.; Prasad, Rajendra; Ambudkar, Suresh V.

    2004-01-01

    To find novel drugs for effective antifungal therapy in candidiasis, we examined disulfiram, a drug used for the treatment of alcoholism, for its role as a potential modulator of Candida multidrug transporter Cdr1p. We show that disulfiram inhibits the oligomycin-sensitive ATPase activity of Cdr1p and 2.5 mM dithiothreitol reverses this inhibition. Disulfiram inhibited the binding of photoaffinity analogs of both ATP ([α- 32 P]8-azidoATP; IC 50 = 0.76 μM) and drug-substrates ([ 3 H]azidopine and [ 125 I]iodoarylazidoprazosin; IC 50 ∼ 12 μM) to Cdr1p in a concentration-dependent manner, suggesting that it can interact with both ATP and substrate-binding site(s) of Cdr1p. Furthermore, a non-toxic concentration of disulfiram (1 μM) increased the sensitivity of Cdr1p expressing Saccharomyces cerevisiae cells to antifungal agents (fluconazole, miconazole, nystatin, and cycloheximide). Collectively these results demonstrate that disulfiram reverses Cdr1p-mediated drug resistance by interaction with both ATP and substrate-binding sites of the transporter and may be useful for antifungal therapy

  6. Correlation between heavy metals and turtle abundance in ponds near the Paducah Gaseous Diffusion Plant, Kentucky, USA.

    Science.gov (United States)

    Yu, Shuangying; Halbrook, Richard S; Sparling, Donald W

    2013-10-01

    Reptiles are declining globally, and environmental contamination has been suggested as a contributing factor; however, few studies have investigated the relationship between contamination and reptile populations. We performed a mark-recapture study at ponds near the Paducah Gaseous Diffusion Plant (PGDP), Kentucky, to determine if heavy metals had an impact on turtle populations. We measured concentrations of cadmium, chromium, copper, lead, and mercury in red-eared slider turtle (Trachemys scripta elegans) tissues and pond sediment and determined the correlation between metal concentrations and red-eared slider density. Metal concentrations measured in the current study were low, and turtle density was not significantly correlated with metal concentrations in tissues or sediment. However, we observed a trend of decreasing turtle density in ponds that had greater metal concentrations. Sex ratio and proportion of juveniles were significantly different among ponds, but it is unclear if these differences are related to contamination associated with the PGDP.

  7. Expression of the CDR1 efflux pump in clinical Candida albicans isolates is controlled by a negative regulatory element

    International Nuclear Information System (INIS)

    Gaur, Naseem Akhtar; Manoharlal, Raman; Saini, Preeti; Prasad, Tulika; Mukhopadhyay, Gauranga; Hoefer, Milan; Morschhaeuser, Joachim; Prasad, Rajendra

    2005-01-01

    Resistance to azole antifungal drugs in clinical isolates of the human fungal pathogen Candida albicans is often caused by constitutive overexpression of the CDR1 gene, which encodes a multidrug efflux pump of the ABC transporter superfamily. To understand the relevance of a recently identified negative regulatory element (NRE) in the CDR1 promoter for the control of CDR1 expression in the clinical scenario, we investigated the effect of mutation or deletion of the NRE on CDR1 expression in two matched pairs of azole-sensitive and resistant clinical isolates of C. albicans. Expression of GFP or lacZ reporter genes from the wild type CDR1 promoter was much higher in the azole-resistant C. albicans isolates than in the azole-susceptible isolates, reflecting the known differences in CDR1 expression in these strains. Deletion or mutation of the NRE resulted in enhanced reporter gene expression in azole-sensitive strains, but did not further increase the already high CDR1 promoter activity in the azole-resistant strains. In agreement with these findings, electrophoretic mobility shift assays showed a reduced binding to the NRE of nuclear extracts from the resistant C. albicans isolates as compared with extracts from the sensitive isolates. These results demonstrate that the NRE is involved in maintaining CDR1 expression at basal levels and that this repression is overcome in azole-resistant clinical C. albicans isolates, resulting in constitutive CDR1 overexpression and concomitant drug resistance

  8. Increased Suicide Risk among Workers following Toxic Metal Exposure at the Paducah Gaseous Diffusion Plant From 1952 to 2003: A Cohort Study

    OpenAIRE

    LW Figgs; H Holsinger; SJ Freitas; GM Brion; RW Hornung; CH Rice; D Tollerud

    2011-01-01

    Background: Suicide is a problem worldwide and occupation is an important risk factor. In the last decade, 55 200 deaths in the US were attributed to occupational risk factors. Objective: To determine if toxic metal exposure was associated with suicide risk among Paducah gaseous diffusion plant (PGDP) workers. Methods: We assembled a cohort of 6820 nuclear industry workers employed from 1952 to 2003. A job-specific exposure matrix (JEM) was used to determine metal exposure likelihoo...

  9. Detecting Treatment Group Differences in Alzheimer's Disease Clinical Trials: A Comparison of Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) and the Clinical Dementia Rating - Sum of Boxes (CDR-SB).

    Science.gov (United States)

    Wessels, A M; Dowsett, S A; Sims, J R

    2018-01-01

    The Alzheimer's Disease Assessment Scale's cognitive subscale (ADAS-Cog) has been widely used as an outcome measure in Alzheimer's Disease (AD) clinical trials. In its original form (ADAS-Cog11), the scale has been used successfully in mild-to-moderate AD dementia populations, but its use is more limited in the study of earlier disease (mild cognitive impairment [MCI] or mild dementia due to AD) owing to lack of appropriate sensitivity of some items. With recent focus on earlier treatment, efforts have focused on the development of more sensitive tools, including the Clinical Dementia Rating-Sum of Boxes (CDR-SB), a global assessment tool to evaluate both cognition and function. The ability of the ADAS-Cog and CDR-SB to detect treatment group differences in the clinical trial environment has not been systematically studied. The aim of this analysis was to compare the utility of these tools in detecting treatment group differences, by reviewing study findings identified through advanced searches of clinicaltrials.gov and Ovid, and press releases and scientific presentations. Findings from placebo-controlled studies of ≥ 6m duration and enrolling >100 participants were included; reporting of both the ADAS-Cog and CDR-SB at endpoint was also a requirement. Of the >300 records identified, 34 studies fulfilled the criteria. There were significant placebo versus active drug group differences based on findings from at least one measure for 14 studies. The ADAS-Cog detected treatment differences more frequently than the CDR-SB. Based on these and previously published findings, the ADAS-Cog appears more useful than the CDR-SB in detecting treatment group differences.

  10. Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions

    Directory of Open Access Journals (Sweden)

    Catherine L Townsend

    2016-09-01

    Full Text Available Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain CDR-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 - light chain variable region sequences from IgM-transcribing, newly formed B cells isolated from human bone marrow and peripheral blood. We also used a published human naïve dataset to investigate the CDR-H3 properties of heavy chains paired with kappa and lambda light chains, and probed the Protein Data Bank (PDB to investigate the structural differences between kappa and lambda antibody CDR regions. We found that kappa and lambda light chains have very different CDR physicochemical and structural properties, whereas the heavy chains with which they are paired do not differ significantly. We also observed that the mean CDR3 N nucleotide addition in the kappa, lambda and heavy chain gene rearrangements are correlated within donors, but can differ between donors. This indicates that TdT may work with differing efficiencies between different people, but the same efficiency in the different classes of immunoglobulin chain within one person. We have observed large differences in the physicochemical and structural properties of kappa and lambda light chain CDR regions. This may reflect different roles in the humoral immune response.

  11. CLIC CDR - physics and detectors: CLIC conceptual design report.

    Energy Technology Data Exchange (ETDEWEB)

    Berger, E.; Demarteau, M.; Repond, J.; Xia, L.; Weerts, H. (High Energy Physics); (Many)

    2012-02-10

    This report forms part of the Conceptual Design Report (CDR) of the Compact LInear Collider (CLIC). The CLIC accelerator complex is described in a separate CDR volume. A third document, to appear later, will assess strategic scenarios for building and operating CLIC in successive center-of-mass energy stages. It is anticipated that CLIC will commence with operation at a few hundred GeV, giving access to precision standard-model physics like Higgs and top-quark physics. Then, depending on the physics landscape, CLIC operation would be staged in a few steps ultimately reaching the maximum 3 TeV center-of-mass energy. Such a scenario would maximize the physics potential of CLIC providing new physics discovery potential over a wide range of energies and the ability to make precision measurements of possible new states previously discovered at the Large Hadron Collider (LHC). The main purpose of this document is to address the physics potential of a future multi-TeV e{sup +}e{sup -} collider based on CLIC technology and to describe the essential features of a detector that are required to deliver the full physics potential of this machine. The experimental conditions at CLIC are significantly more challenging than those at previous electron-positron colliders due to the much higher levels of beam-induced backgrounds and the 0.5 ns bunch-spacing. Consequently, a large part of this report is devoted to understanding the impact of the machine environment on the detector with the aim of demonstrating, with the example of realistic detector concepts, that high precision physics measurements can be made at CLIC. Since the impact of background increases with energy, this document concentrates on the detector requirements and physics measurements at the highest CLIC center-of-mass energy of 3 TeV. One essential output of this report is the clear demonstration that a wide range of high precision physics measurements can be made at CLIC with detectors which are challenging, but

  12. Cdr2p contributes to fluconazole resistance in Candida dubliniensis clinical isolates.

    LENUS (Irish Health Repository)

    2011-05-01

    The development of resistance to azole antifungals used in the treatment of fungal infections can be a serious medical problem. Here, we investigate the molecular mechanisms associated with reduced susceptibility to fluconazole in clinical isolates of Candida dubliniensis , showing evidence of the trailing growth phenomenon. The changes in membrane sterol composition were studied in the presence of subinhibitory fluconazole concentrations. Despite lanosterol and eburicol accumulating as the most prevalent sterols after fluconazole treatment, these ergosterol precursors still support growth of Candida isolates. The overexpression of ABC transporters was demonstrated by immunoblotting employing specific antibodies against Cdr1p and Cdr2p. The presence of a full-length 170 kDa protein Cdr1p was detected in two isolates, while a truncated form of Cdr1p with the molecular mass of 85 kDa was observed in isolate 966\\/3(2). Notably, Cdr2p was detected in this isolate, and the expression of this transporter was modulated by subinhibitory concentrations of fluconazole. These results suggest that C. dubliniensis can display the trailing growth phenomenon, and such isolates express similar molecular mechanisms like that of fluconazole-resistant isolates and can therefore be associated with recurrent infections.

  13. Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients

    Directory of Open Access Journals (Sweden)

    João Guilherme Fiorani Borgio

    2012-11-01

    Full Text Available OBJECTIVE: To evaluate the combination of two factors: clinical dementia rating sum of boxes scores (CDR-SB and hippocampal volume (HV as predictors of conversion from mild cognitive impairment (MCI to dementia. METHODS: Twenty-eight individuals (9 normal and 19 with MCI were classified according to their CDR sum of boxes scores into 3 groups. RESULTS: The hippocampal volume was significantly lower in the high-risk group and in those who developed dementia after two years. The rate of conversion was crescent among the three groups. CONCLUSION: We were proposed an additional measurement of the hippocampal volume which may be helpful in the prognosis. However, we noted that the CDR-SB is a method as efficient as neuroimaging to predict dementia with the advantage of being a procedure for low cost and easy implementation, more consistent with public policy.

  14. Refurbishment of uranium hexafluoride cylinder storage yards C-745-K, L, M, N, and P and construction of a new uranium hexafluoride cylinder storage yard (C-745-T) at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    The Paducah Gaseous Diffusion Plant (PGDP) is a uranium enrichment facility owned by the US Department of Energy (DOE). A residual of the uranium enrichment process is depleted uranium hexafluoride (UF6). Depleted UF6, a solid at ambient temperature, is stored in 32,200 steel cylinders that hold a maximum of 14 tons each. Storage conditions are suboptimal and have resulted in accelerated corrosion of cylinders, increasing the potential for a release of hazardous substances. Consequently, the DOE is proposing refurbishment of certain existing yards and construction of a new storage yard. This environmental assessment (EA) evaluates the impacts of the proposed action and no action and considers alternate sites for the proposed new storage yard. The proposed action includes (1) renovating five existing cylinder yards; (2) constructing a new UF6 storage yard; handling and onsite transport of cylinders among existing yards to accommodate construction; and (4) after refurbishment and construction, restacking of cylinders to meet spacing and inspection requirements. Based on the results of the analysis reported in the EA, DOE has determined that the proposed action is not a major Federal action that would significantly affect the quality of the human environment within the context of the National Environmental Policy Act of 1969. Therefore, DOE is issuing a Finding of No Significant Impact. Additionally, it is reported in this EA that the loss of less than one acre of wetlands at the proposed project site would not be a significant adverse impact.

  15. Refurbishment of uranium hexafluoride cylinder storage yards C-745-K, L, M, N, and P and construction of a new uranium hexafluoride cylinder storage yard (C-745-T) at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    1996-07-01

    The Paducah Gaseous Diffusion Plant (PGDP) is a uranium enrichment facility owned by the US Department of Energy (DOE). A residual of the uranium enrichment process is depleted uranium hexafluoride (UF6). Depleted UF6, a solid at ambient temperature, is stored in 32,200 steel cylinders that hold a maximum of 14 tons each. Storage conditions are suboptimal and have resulted in accelerated corrosion of cylinders, increasing the potential for a release of hazardous substances. Consequently, the DOE is proposing refurbishment of certain existing yards and construction of a new storage yard. This environmental assessment (EA) evaluates the impacts of the proposed action and no action and considers alternate sites for the proposed new storage yard. The proposed action includes (1) renovating five existing cylinder yards; (2) constructing a new UF6 storage yard; handling and onsite transport of cylinders among existing yards to accommodate construction; and (4) after refurbishment and construction, restacking of cylinders to meet spacing and inspection requirements. Based on the results of the analysis reported in the EA, DOE has determined that the proposed action is not a major Federal action that would significantly affect the quality of the human environment within the context of the National Environmental Policy Act of 1969. Therefore, DOE is issuing a Finding of No Significant Impact. Additionally, it is reported in this EA that the loss of less than one acre of wetlands at the proposed project site would not be a significant adverse impact

  16. A Wide Lock-Range Referenceless CDR with Automatic Frequency Acquisition

    OpenAIRE

    Seon-Kyoo Lee; Young-Sang Kim; Hong-June Park; Jae-Yoon Sim

    2011-01-01

    A wide lock-range referenceless CDR circuit is proposed with an automatic tracking of data rate. For efficient frequency acquisition, a DLL-based loop is used with a simple phase/frequency detector to extract 1-bit period of input data stream. The CDR, implemented in a 65 nm CMOS, shows a lock range of 650 Mb/s-to-8 Gb/s and BER of less than 10-12 at 8 Gb/s with low power consumption.

  17. A Wide Lock-Range Referenceless CDR with Automatic Frequency Acquisition

    Directory of Open Access Journals (Sweden)

    Seon-Kyoo Lee

    2011-01-01

    Full Text Available A wide lock-range referenceless CDR circuit is proposed with an automatic tracking of data rate. For efficient frequency acquisition, a DLL-based loop is used with a simple phase/frequency detector to extract 1-bit period of input data stream. The CDR, implemented in a 65 nm CMOS, shows a lock range of 650 Mb/s-to-8 Gb/s and BER of less than 10-12 at 8 Gb/s with low power consumption.

  18. U.S. child death review programs: assessing progress toward a standard review process.

    Science.gov (United States)

    Shanley, Jenelle R; Risch, Elizabeth C; Bonner, Barbara L

    2010-12-01

    Child death review (CDR) programs examine the circumstances of children's deaths to gain information on how and why children die for the purpose of promoting the health, safety, and protection of children. The purpose of this study was to conduct a systematic review of the 50 states and District of Columbia CDR programs, with specific focus on the use of standardized procedures and best-practice recommendations. This included assessment of which deaths are reviewed, the model of review, team membership, and standardization of data collection and reporting. Data were collected through semistructured phone interviews with representatives of the 50 states and District of Columbia CDR programs and online sources. Data collection and analyses were conducted in 2009. Forty-eight states and the District of Columbia have active CDR programs at the state and/or local level, and the majority use a national data collection system. However, results revealed numerous inconsistencies across programs in policies, procedures, and data collection. This study reflects the minimal progress that has been made in the CDR process in the U.S. since the last systematic review of the programs in 2001. The study documents substantial discrepancies among the U.S. CDR programs, affecting the consistency of data obtained by individual states and, ultimately, prevention efforts at the national level. Information from this review can inform CDR programs as they develop and refine procedures and guide future research on the effectiveness and limitations of variations in procedures. Copyright © 2010 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  19. Sampling and Analysis at the Vortec Vitrification Facility in Paducah, Kentucky. Semiannual report, November 1, 1996--March 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Laudal, Dennis L.; Lillemoen, Carolyn M.; Hurley, John P.; Ness, Sumitra R.; Stepan, Daniel J.; Thompson, Jeffrey, S.

    1997-12-31

    The Vortec Cyclone Melting System (CMS) facility; to be located at the U.S. Department of Energy (DOE) Paducah Gaseous Diffusion Plant, is designed to treat soil contaminated with low levels of heavy metals and radioactive elements, as well as organic waste. The primary components of Vortec`s CMS are a counter rotating vortex (CRV) reactor and cyclone melter. In the CMS process, granular glass forming ingredients and other feedstocks are introduced into the CRV reactor where the intense CRV mixing allows the mixture to achieve a stable reaction and rapid heating of the feedstock materials. Organic contaminants in the feedstock are effectively oxidized, and the inert inorganic solids are melted. The University of North Dakota Energy {ampersand} Environmental Research Center (EERC) has been contacted to help in the development of sampling plans and to conduct the sampling at the facility. This document is written in a format that assumes that the EERC will perform the sampling activities and be in charge of sample chain of custody, but that another laboratory will perform required sample analyses.

  20. Sampling and Analysis at the Vortec Vitrification Facility in Paducah, Kentucky. Semiannual report, November 1, 1996--March 31, 1997

    International Nuclear Information System (INIS)

    Laudal, Dennis L.; Lillemoen, Carolyn M.; Hurley, John P.; Ness, Sumitra R.; Stepan, Daniel J.; Thompson, Jeffrey S.

    1997-01-01

    The Vortec Cyclone Melting System (CMS) facility; to be located at the U.S. Department of Energy (DOE) Paducah Gaseous Diffusion Plant, is designed to treat soil contaminated with low levels of heavy metals and radioactive elements, as well as organic waste. The primary components of Vortec's CMS are a counter rotating vortex (CRV) reactor and cyclone melter. In the CMS process, granular glass forming ingredients and other feedstocks are introduced into the CRV reactor where the intense CRV mixing allows the mixture to achieve a stable reaction and rapid heating of the feedstock materials. Organic contaminants in the feedstock are effectively oxidized, and the inert inorganic solids are melted. The University of North Dakota Energy ampersand Environmental Research Center (EERC) has been contacted to help in the development of sampling plans and to conduct the sampling at the facility. This document is written in a format that assumes that the EERC will perform the sampling activities and be in charge of sample chain of custody, but that another laboratory will perform required sample analyses

  1. Environmental exposure to polychlorinated biphenyls among raccoons (Procyon lotor) at the paducah gaseous diffusion plant, Western Kentucky, USA.

    Science.gov (United States)

    Smith, Philip N; Johnson, Kevin A; Anderson, Todd A; McMurry, Scott T

    2003-02-01

    An investigation involving raccoons (Procyon lotor) as a sentinel species at the Paducah Gaseous Diffusion Plant (PGDP) in Western Kentucky (USA) delineated the extent of exposure to polychlorinated biphenyls (PCBs) and PCB spatial distribution. Raccoon exposure to PCBs was demonstrated through analysis of subcutaneous fat, abdominal fat, liver, and brain tissues from raccoons collected at the PGDP but also was clearly evident in raccoons from a reference area situated along the Ohio River (USA). Raccoons with the highest tissue PCB concentrations appeared to be those inhabiting areas nearest the plant itself and most likely those that ventured into the plants interior. Male raccoons at the PGDP had similar concentrations of total PCBs in subcutaneous fat (1.86 +/- 0.64 microg/g) as males from the reference site (1.41 +/- 0.35 microg/g), but females had higher PCB body burdens than those at the reference site (9.90 +/- 6.13 microg/g vs 0.75 +/- 0.40 microg/g). Gross measurements of exposure to radiation-producing materials revealed that counts per minute exceeded background in 61% of PGDP raccoons compared with 27% at the reference site and five raccoons at the PGDP had beta counts that were more than twice the background. Differences among trapping success, growth rates, and serum chemistry parameters were noted but may have been related to habitat and other environmental and population density factors.

  2. Detection of inhibitors of Candida albicans Cdr transporters using a diS-C3(3 fluorescence

    Directory of Open Access Journals (Sweden)

    Joanna eSzczepaniak

    2015-03-01

    Full Text Available Candida albicans is a major cause of opportunistic and life-threatening, systemic fungal infections. Hence new antifungal agents, as well as new methods to treat fungal infections, are still needed. The application of inhibitors of drug-efflux pumps may increase the susceptibility of C. albicans to drugs. We developed a new fluorescence method that allows the in vivo activity evaluation of compounds inhibiting of C. albicans transporters. We show that the potentiometric dye 3,3′-dipropylthiacarbocyanine iodide diS-C3(3 is pumped out by both Cdr1 and Cdr2 transporters. The fluorescence labeling with diS-C3(3 enables a real-time observation of the activity of C. albicans Cdr1 and Cdr2 transporters. We demonstrate that enniatin A and beauvericin show different specificities toward these transporters. Enniatin A inhibits diS-C3(3 efflux by Cdr1 while beauvericin inhibits both Cdr1p and Cdr2p.

  3. Between Scylla and Charybdis: Delayed mitigation narrows the passage between large-scale CDR and high costs

    Science.gov (United States)

    Strefler, Jessica; Bauer, Nico; Kriegler, Elmar; Popp, Alexander; Giannousakis, Anastasis; Edenhofer, Ottmar

    2018-04-01

    There are major concerns about the sustainability of large-scale deployment of carbon dioxide removal (CDR) technologies. It is therefore an urgent question to what extent CDR will be needed to implement the long term ambition of the Paris Agreement. Here we show that ambitious near term mitigation significantly decreases CDR requirements to keep the Paris climate targets within reach. Following the nationally determined contributions (NDCs) until 2030 makes 2 °C unachievable without CDR. Reducing 2030 emissions by 20% below NDC levels alleviates the trade-off between high transitional challenges and high CDR deployment. Nevertheless, transitional challenges increase significantly if CDR is constrained to less than 5 Gt CO2 a‑1 in any year. At least 8 Gt CO2 a‑1 CDR are necessary in the long term to achieve 1.5 °C and more than 15 Gt CO2 a‑1 to keep transitional challenges in bounds.

  4. Biological assessment of the effects of construction and operation of a depleted uranium hexafluoride conversion facility at the Paducah, Kentucky, site.

    Energy Technology Data Exchange (ETDEWEB)

    Van Lonkhuyzen, R.

    2005-09-09

    The U.S. Department of Energy (DOE) Depleted Uranium Hexafluoride (DUF{sub 6}) Management Program evaluated alternatives for managing its inventory of DUF{sub 6} and issued the ''Programmatic Environmental Impact Statement for Alternative Strategies for the Long-Term Management and Use of Depleted Uranium Hexafluoride'' (DUF{sub 6} PEIS) in April 1999 (DOE 1999). The DUF{sub 6} inventory is stored in cylinders at three DOE sites: Paducah, Kentucky; Portsmouth, Ohio; and East Tennessee Technology Park (ETTP), near Oak Ridge, Tennessee. In the Record of Decision for the DUF{sub 6} PEIS, DOE stated its decision to promptly convert the DUF6 inventory to a more stable chemical form. Subsequently, the U.S. Congress passed, and the President signed, the ''2002 Supplemental Appropriations Act for Further Recovery from and Response to Terrorist Attacks on the United States'' (Public Law No. 107-206). This law stipulated in part that, within 30 days of enactment, DOE must award a contract for the design, construction, and operation of a DUF{sub 6} conversion plant at the Department's Paducah, Kentucky, and Portsmouth, Ohio, sites, and for the shipment of DUF{sub 6} cylinders stored at ETTP to the Portsmouth site for conversion. This biological assessment (BA) has been prepared by DOE, pursuant to the National Environmental Policy Act of 1969 (NEPA) and the Endangered Species Act of 1974, to evaluate potential impacts to federally listed species from the construction and operation of a conversion facility at the DOE Paducah site.

  5. Software and Parameters for Detailed TPC Studies in the CLIC CDR

    CERN Document Server

    Killenberg, M.

    2011-01-01

    For the TPC occupancy and time stamping studies in the CLIC CDR the MarlinTPC software package has been used in combination with Mokka for the full detector simulation. This document describes the working principle of the Marlin processors used for digitisation and reconstruction, and lists the parameters for reference.

  6. How Do Scores on the ADAS-Cog, MMSE, and CDR-SOB Correspond?

    Science.gov (United States)

    Balsis, Steve; Benge, Jared F; Lowe, Deborah A; Geraci, Lisa; Doody, Rachelle S

    2015-01-01

    Clinicians and researchers who measure cognitive dysfunction often use the Alzheimer's Disease Assessment Scale--Cognitive Subscale (ADAS-Cog), the Mini-Mental State Examination (MMSE), or the Clinical Dementia Rating scale (CDR-SOB). But, the use of different measures can make it difficult to compare data across patients or studies. What is needed is a simple chart that shows how scores on these three important measures correspond to each other. Using data from 1709 participants from the Alzheimer's Disease Neuroimaging Initiative and item response theory-based statistics, we analyzed how scores on each measure, the ADAS-Cog, the MMSE, and the CDR-SOB, correspond. Results indicated multiple inflections in CDR-SOB and ADAS-Cog scores within a given MMSE score, suggesting that the CDR-SOB and ADAS-Cog are more precise in measuring the severity of cognitive dysfunction than the MMSE. This study shows how scores on these three popular measures of cognitive dysfunction correspond to each other, which is very useful information for both researchers and clinicians.

  7. CLIC Detector Concepts as described in the CDR: Differences between the GEANT4 and Engineering Models

    CERN Document Server

    Elsener, K; Schlatter, D; Siegrist, N

    2011-01-01

    The CLIC_ILD and CLIC_SiD detector concepts as used for the CDR Vol. 2 in 2011 exist both in GEANT4 simulation models and in engineering layout drawings. At this early stage of a conceptual design, there are inevitably differences between these models, which are described in this note.

  8. Theoretical Modeling and Simulation of Phase-Locked Loop (PLL for Clock Data Recovery (CDR

    Directory of Open Access Journals (Sweden)

    Zainab Mohamad Ashari

    2012-01-01

    Full Text Available Modern communication and computer systems require rapid (Gbps, efficient  and large bandwidth data transfers. Agressive scaling of digital integrated systems  allow buses and communication controller circuits to be integrated with the microprocessor on the same chip. The  Peripheral Component Interconnect Express (PCIe protocol handles all communcation between the central processing unit (CPU and hardware devices. PCIe buses require efficient clock data recovery circuits (CDR to recover clock signals embedded in data during transmission. This paper describes the theoretical modeling and simulation of a phase-locked loop (PLL used in a CDR circuit. A simple PLL architecture for a 5 GHz CDR circuit is proposed  and elaborated in this work. Simulations were carried out using a Hardware Description Language, Verilog-AMS. The effect of jitter on the proposed design is also simulated and evaluated in this work. It was found that the proposed design is robust against both input and VCO jitter.ABSTRAK: Sistem komunikasi dan komputer moden memerlukan pemindahan data yang cekap (Gbps, dan bandwidth yang besar. Pengecilan agresif menggunakan teknik sistem digital bersepadu membenarkan bas dan litar pengawal komunikasi disatukan dengan  mikroprocessor dalam cip yang sama. Protokol persisian komponen sambung tara ekspres (PCIe mengendalikan semua komunikasi antara unit pemprosesan pusat (CPU dan peranti perkakasan. Bas PCIe memerlukan litar jam pemulihan data (CDR yang cekap untuk mendapatkan kembali isyarat jam yang tertanam dalam data semasa transmisi. Karya ini menerangkan teori pemodelan dan simulasi gelung fasa terkunci (PLL untuk CDR. Rekabentuk 5 GHz PLL yang mudah telah dicadangkan dalm kertas kerja ini. Simulasi telah dijalankan menggunakan perisian verilog-AMS. Simulasi mengunnakan kesan ketar dalam reka bentuk yang dicadangkan telah dinilai. Reka bentuk yang dicadangkan terbukti teguh mengatasi ganguan ketar di input dan VCO.KEY WORDS

  9. TECHNICAL EVALUATION OF TEMPORAL GROUNDWATER MONITORING VARIABILITY IN MW66 AND NEARBY WELLS, PADUCAH GASEOUS DIFFUSION PLANT

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Eddy-Dilek, C.

    2012-08-28

    Evaluation of disposal records, soil data, and spatial/temporal groundwater data from the Paducah Gaseous Diffusion Plant (PGDP) Solid Waste Management Unit (SWMU) 7 indicate that the peak contaminant concentrations measured in monitoring well (MW) 66 result from the influence of the regional PGDP NW Plume, and does not support the presence of significant vertical transport from local contaminant sources in SWMU 7. This updated evaluation supports the 2006 conceptualization which suggested the high and low concentrations in MW66 represent different flow conditions (i.e., local versus regional influences). Incorporation of the additional lines of evidence from data collected since 2006 provide the basis to link high contaminant concentrations in MW66 (peaks) to the regional 'Northwest Plume' and to the upgradient source, specifically, the C400 Building Area. The conceptual model was further refined to demonstrate that groundwater and the various contaminant plumes respond to complex site conditions in predictable ways. This type of conceptualization bounds the expected system behavior and supports development of environmental cleanup strategies, providing a basis to support decisions even if it is not feasible to completely characterize all of the 'complexities' present in the system. We recommend that the site carefully consider the potential impacts to groundwater and contaminant plume migration as they plan and implement onsite production operations, remediation efforts, and reconfiguration activities. For example, this conceptual model suggests that rerouting drainage water, constructing ponds or basin, reconfiguring cooling water systems, capping sites, decommissioning buildings, fixing (or not fixing) water leaks, and other similar actions will potentially have a 'direct' impact on the groundwater contaminant plumes. Our conclusion that the peak concentrations in MW66 are linked to the regional PGDP NW Plume does not imply that

  10. NOAA Climate Data Record (CDR) of Advanced Microwave Sounding Unit (AMSU)-A Brightness Temperature, Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Climate Data Record (CDR) for Advanced Microwave Sounding Unit-A (AMSU-A) brightness temperature in "window channels". The data cover a time period from...

  11. NOAA Climate Data Record (CDR) of Zonal Mean Ozone Binary Database of Profiles (BDBP), version 1.0

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of Zonal Mean Ozone Binary Database of Profiles (BDBP) dataset is a vertically resolved, global, gap-free and zonal mean dataset...

  12. NOAA Climate Data Record (CDR) of SSM/I and SSMIS Microwave Brightness Temperatures, CSU Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) from Colorado State University (CSU) contains brightness temperatures that have been improved and quality-controlled over the...

  13. NOAA Climate Data Record (CDR) of SSM/I and SSMIS Microwave Brightness Temperatures, RSS Version 7

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Version 7 NOAA Fundamental Climate Data Record (CDR) from Remote Sensing Systems (RSS) contains brightness temperatures that have been inter-calibrated and...

  14. NOAA Climate Data Record (CDR) of MSU and AMSU-A Mean Layer Temperatures, UAH Version 5.4 (Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Please note: this dataset has been superseded by a newer version (see below). This version is archived offline by NOAA NCEI. This Climate Data Record (CDR) includes...

  15. NOAA Climate Data Record (CDR) of Cloud Properties from AVHRR Pathfinder Atmospheres - Extended (PATMOS-x), Version 5.3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of cloud products was produced by the University of Wisconsin using the AVHRR Pathfinder Atmospheres - Extended (PATMOS-X)...

  16. MESSENGER E/V/H MLA 3/4 CDR/RDR DATA V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — Abstract ======== This data set consists of the MESSENGER Mercury Laser Altimeter (MLA) Calibrated Data Record (CDR) and Reduced Data Record (RDR) products. The MLA...

  17. PHENIX CDR update: An experiment to be performed at the Brookhaven National Laboratory relativistic heavy ion collider. Revision

    Energy Technology Data Exchange (ETDEWEB)

    1994-11-01

    The PHENIX Conceptual Design Report Update (CDR Update) is intended for use together with the Conceptual Design Report (CDR). The CDR Update is a companion document to the CDR, and it describes the collaboration`s progress since the CDR was submitted in January 1993. Therefore, this document concentrates on changes, refinements, and decisions that have been made over the past year. These documents together define the baseline PHENIX detector that the collaboration intends to build for operation at RHIC startup. In this chapter the current status of the detector and its motivation are briefly described. In Chapters 2 and 3 the detector and the physics performance are more fully developed. In Chapters 4 through 13 the details of the present design status, the technology choices, and the construction costs and schedules are presented. The physics goals of PHENIX collaboration have remained exactly as they were described in the CDR. Primary among these is the detection of a new phase of matter, the quark-gluon plasma (QGP), and the measurement of its properties. The PHENIX experiment will measure many of the best potential QGP signatures to see if any or all of these physics variables show anomalies simultaneously due to the formation of the QGP.

  18. Impact in stability during sequential CDR grafting to construct camelid VHH antibodies against zinc oxide and gold.

    Science.gov (United States)

    Saito, Ryota; Saito, Yutaro; Nakazawa, Hikaru; Hattori, Takamitsu; Kumagai, Izumi; Umetsu, Mitsuo; Makabe, Koki

    2018-01-22

    Biomolecules which recognize inorganic materials and metal surfaces gain much attention for creating new type of nanomaterials and sensors. 4F2, a camelid VHH antibody, recognizes ZnO surface and has been applied for sensor applications. 4F2 was constructed sequential CDR replacement on the parental VHH antibody, termed the Construction of Antibody by Integrating Grafting and Evolution Technology; CAnIGET procedure. Here, we evaluate the influence of CDR replacements during 4F2 generation using calorimetric technique. We found that the initial peptide grafting at CDR1 results in the stability reduction and subsequent CDR3 randomize and selection restore the stability during the construction of 4F2. Further examination using anti-gold VHH, AuE32, revealed that the final CDR3 randomize and selection step has little effect in stability while the initial CDR1 grafting reduces the stability as same as the case for 4F2. Our results showing here provide the detailed view of the stability alteration during the CAnIGET procedure. © The Authors 2018. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

  19. PHENIX CDR update: An experiment to be performed at the Brookhaven National Laboratory relativistic heavy ion collider. Revision

    International Nuclear Information System (INIS)

    1994-11-01

    The PHENIX Conceptual Design Report Update (CDR Update) is intended for use together with the Conceptual Design Report (CDR). The CDR Update is a companion document to the CDR, and it describes the collaboration's progress since the CDR was submitted in January 1993. Therefore, this document concentrates on changes, refinements, and decisions that have been made over the past year. These documents together define the baseline PHENIX detector that the collaboration intends to build for operation at RHIC startup. In this chapter the current status of the detector and its motivation are briefly described. In Chapters 2 and 3 the detector and the physics performance are more fully developed. In Chapters 4 through 13 the details of the present design status, the technology choices, and the construction costs and schedules are presented. The physics goals of PHENIX collaboration have remained exactly as they were described in the CDR. Primary among these is the detection of a new phase of matter, the quark-gluon plasma (QGP), and the measurement of its properties. The PHENIX experiment will measure many of the best potential QGP signatures to see if any or all of these physics variables show anomalies simultaneously due to the formation of the QGP

  20. Comparisons of Safety and Clinical Outcomes Between Multiple-level and Single-level Cervical Disk Replacement for Cervical Spondylosis: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Jiang, Lianghai; Tan, Mingsheng; Yang, Feng; Yi, Ping; Tang, Xiangsheng; Hao, Qingying

    2016-12-01

    This is a systematic review and meta-analysis. The aim of this study was to evaluate the efficacy and safety of multiple-level cervical disk replacement (CDR) over single-level CDR for the treatment of cervical spondylosis. Some authors advocate for the multiple-level CDR instead of anterior decompression and fusion in cervical multiple-level spondylosis. However, whether the efficacy and safety of multi-level CDR are as favorable as that of single-level CDR remains controversial. MEDLINE, EMBASE, and Cochrane library databases were searched up to November 2015 for controlled studies that compared the clinical outcomes of single-level and multiple-level CDR for the treatment of cervical spondylosis. The following outcomes were extracted and analyzed: prevalence of heterotopic ossification and reoperation, preoperative and postoperative Neck Disability Index scores, preoperative and postoperative Visual Analog Scale scores, and success rate using the Odom grading system. Ten studies involving 1402 patients were included: including 3 randomized controlled trials, 5 prospective studies, and 3 retrospective studies. No significant differences between single-level and multiple-level groups were found in terms of the prevalence of heterotopic ossification and reoperation rate, Neck Disability Index score, Visual Analog Scale score, and success rate using the Odom grading system. On the basis of this meta-analysis, clinical outcomes of multiple-level CDR are similar to those of single-level CDR for cervical spondylosis, which suggests the multiple-level CDR is as effective and safe as the single-level CDR. Nonetheless, more well-designed studies are needed for further evaluation.

  1. The physics benchmark processes for the detector performance studies used in CLIC CDR Volume 3

    CERN Document Server

    Allanach, B.J.; Desch, K.; Ellis, J.; Giudice, G.; Grefe, C.; Kraml, S.; Lastovicka, T.; Linssen, L.; Marschall, J.; Martin, S.P.; Muennich, A.; Poss, S.; Roloff, P.; Simon, F.; Strube, J.; Thomson, M.; Wells, J.D.

    2012-01-01

    This note describes the detector benchmark processes used in volume 3 of the CLIC conceptual design report (CDR), which explores a staged construction and operation of the CLIC accelerator. The goal of the detector benchmark studies is to assess the performance of the CLIC ILD and CLIC SiD detector concepts for different physics processes and at a few CLIC centre-of-mass energies.

  2. Evaluation of PERSIANN-CDR for Meteorological Drought Monitoring over China

    Directory of Open Access Journals (Sweden)

    Hao Guo

    2016-05-01

    Full Text Available In this paper, Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks–Climate Data Record (PERSIANN-CDR is analyzed for the assessment of meteorological drought. The evaluation is conducted over China at 0.5° spatial resolution against a ground-based gridded China monthly Precipitation Analysis Product (CPAP from 1983 to 2014 (32 years. The Standardized Precipitation Index (SPI at various time scales (1 month to 12 months is calculated for detecting drought events. The results show that PERSIANN-CDR depicts similar drought behavior as the ground-based CPAP in terms of capturing the spatial and temporal patterns of drought events over eastern China, where the intensity of gauge networks and the frequency of droughts are high. 6-month SPI shows the best agreement with CPAP in identifying drought months. However, large differences between PERSIANN-CDR and CPAP in depicting drought patterns and identifying specific drought events are found over northwestern China, particularly in Xinjiang and Qinghai-Tibet Plateau region. Factors behind this may be due to the relatively sparse gauge networks, the complicated terrain and the performance of PERSIANN algorithm.

  3. A normal T cell receptor beta CDR3 length distribution in patients with APECED.

    Science.gov (United States)

    Niemi, Heikki J; Laakso, Sini; Salminen, Jukka T; Arstila, T Petteri; Tuulasvaara, Anni

    2015-06-01

    Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by mutations in the AIRE gene. Murine studies suggest that AIRE controls thymic expression of tissue-restricted antigens, its absence allowing nonselected autoreactive cells to escape. We tested this in humans using the TCRβ CDR3 length repertoire as a surrogate of thymic selection, as it shortens during the process. Analysis of healthy thymuses showed an altogether 1.9 base pair shortening, starting at the CD4(+)CD8(+)CD3(low) stage and continuing until the CD4(+) subset, likely encompassing both the positive and negative selection. Comparison of five APECED patients with eight healthy controls showed a skewed repertoire with oligoclonal expansions in the patients' CD4(+) and CD8(+) populations. The average CDR3 length, however, was normal and unaffected by the skewing. This was also true of the hypothesized autoreactive CD8(+)CD45RA(+) population. We failed to detect a subset with an abnormally long CDR3 repertoire, as would be predicted by a failure in selection. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. ATBUJET VOLUME 7 NO. 1 Final.cdr

    African Journals Online (AJOL)

    Sharpe. Index, Treynor Index ... namely income and capital gain. The rate of returns for each REITS was calculated, the return on the ..... Corporate income taxes and the cost of capital; a correction. American. Economic Review, 53(3), 433 - 43 .

  5. vol. 11 no 1 june 2012 - correction article 7.cdr

    African Journals Online (AJOL)

    FinePrint

    2012-06-01

    Jun 1, 2012 ... JMBR: A Peer-review Journal of Biomedical Sciences. June 2012, Vol. .... He apparently tolerated the procedure well initially, only ... common ventricular chamber via a common mildly regurgitant atrio- ventricular valve (Fig V). The common ventricle has fine trabeculations. There is a smaller subaortic right- ...

  6. NJP Volume 38 Number 1 PDF.cdr

    African Journals Online (AJOL)

    Prof Ezechukwu

    progress. While authors need the visibility and the academic points which publications in journals provide, they (authors) must at all times consider the greater interest of the larger society. Editors and reviewers have limited capacity to pick up duplicate, redundant or even plagiarized papers so that, ultimately, the integrity of ...

  7. COMBINED GEOPHYSICAL INVESTIGATION TECHNIQUES TO IDENTIFY BURIED WASTE IN AN UNCONTROLLED LANDFILL AT THE PADUCAH GASEOUS DIFFUSION PLANT, KENTUCKY

    International Nuclear Information System (INIS)

    Miller, Peter T.; Starmer, R. John

    2003-01-01

    The primary objective of the investigation was to confirm the presence and determine the location of a cache of 30 to 60 buried 55-gallon drums that were allegedly dumped along the course of the pre-existing, northsouth diversion ditch (NSDD) adjacent to permitted landfills at the Paducah Gaseous Diffusion Plant, Kentucky. The ditch had been rerouted and was being filled and re-graded at the time of the alleged dumping. Historic information and interviews with individuals associated with alleged dumping activities indicated that the drums were dumped prior to the addition of other fill materials. In addition, materials alleged to have been dumped in the ditch, such as buried roofing materials, roof flashing, metal pins, tar substances, fly ash, and concrete rubble complicated data interpretation. Some clean fill materials have been placed over the site and graded. This is an environment that is extremely complicated in terms of past waste dumping activities, construction practices and miscellaneous landfill operations. The combination of site knowledge gained from interviews and research of existing site maps, variable frequency EM data, classical total magnetic field data and optimized GPR lead to success where a simpler less focused approach by other investigators using EM-31 and EM-61 electromagnetic methods and unfocused ground penetrating radar (GPR)did not produce results and defined no real anomalies. A variable frequency electromagnetic conductivity unit was used to collect the EM data at 3,030 Hz, 5,070 Hz, 8,430 Hz, and 14,010 Hz. Both in-phase and quadrature components were recorded at each station point. These results provided depth estimates for targets and some information on the subsurface conditions. A standard magnetometer was used to conduct the magnetic survey that showed the locations and extent of buried metal, the approximate volume of ferrous metal present within a particular area, and allowed estimation of approximate target depths. The GPR

  8. Turkish Cloud-Radiation Database (CRD) and Its Application with CDR Bayesian Probability Algorithm

    Science.gov (United States)

    Oztopal, A.; Mugnai, A.; Casella, D.; Formenton, M.; Sano, P.; Sonmez, I.; Sen, Z.; Hsaf Team

    2010-12-01

    ABSTRACT It is rather a very difficult task to determine ground rainfall amounts from few Special Sensor Microwave Imager/Sounder (SSMI/S) channels. Although ground rainfall cannot be observed from the space directly, but knowledge about the cloud physics helps to estimate the amound of ground rainfall. SSMI/S includes so much information about the atmospheric structure, however it cannot provide cloud micro-physical structural information. In such a situation, in the rainfall algorithm, besides the SSMI/S data, it is necessary to incorporate cloud micro-physical properties from an external data source. These properties can be obtained quite simply by the help of Cloud Resolving Model (CRM). Later, in addition to all available data, also micro-physical properties obtained from Radiative Transfer Model (RTM) help to determine the SSMI/S brightness temperatures (Brightness temperatures - TBs), which can then be correlated with Cloud-Radiation Database (CRD) data generation. SSMI/S satellite data and CDR provide a common basis for rainfall prediction procedure through CDR Bayesian probability algorithm, which combines the two sets of data in a scientific manner. The first applications of this algorithm, which is being used up today, is due to various researchers. In this work, in order to establish a reflection of available data processing CDR CRM University of Wisconsin - Non-hydrostatic Modeling System (UW-NMS) model is employed, which is first developed by Prof. Gregory J. Tripoli. It is also used by Turkish Meteorological Service by benefiting from radar network data, and finally 14 simulations are realized in this study. Moreover, one case study is fulfilled by using a 3X3 spatial filtering, and then radar data and result of CDR Bayesian probability algorithm are compared with each other. On 9 September 2009 at 03:40 GMT rainfall event on comparatively flat area matches far better with the retrieval values and hence the spatial rainfall occurrence extent and

  9. BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome

    International Nuclear Information System (INIS)

    Pickman, Yishai; Mehr, Ramit; Dunn-Walters, Deborah

    2013-01-01

    Complementarity-determining region 3 (CDR3) is the most hyper-variable region in B cell receptor (BCR) and T cell receptor (TCR) genes, and the most critical structure in antigen recognition and thereby in determining the fates of developing and responding lymphocytes. There are millions of different TCR Vβ chain or BCR heavy chain CDR3 sequences in human blood. Even now, when high-throughput sequencing becomes widely used, CDR3 length distributions (also called spectratypes) are still a much quicker and cheaper method of assessing repertoire diversity. However, distribution complexity and the large amount of information per sample (e.g. 32 distributions of the TCRα chain, and 24 of TCRβ) calls for the use of machine learning tools for full exploration. We have examined the ability of supervised machine learning, which uses computational models to find hidden patterns in predefined biological groups, to analyze CDR3 length distributions from various sources, and distinguish between experimental groups. We found that (a) splenic BCR CDR3 length distributions are characterized by low standard deviations and few local maxima, compared to peripheral blood distributions; (b) healthy elderly people's BCR CDR3 length distributions can be distinguished from those of the young; and (c) a machine learning model based on TCR CDR3 distribution features can detect myelodysplastic syndrome with approximately 93% accuracy. Overall, we demonstrate that using supervised machine learning methods can contribute to our understanding of lymphocyte repertoire diversity. (paper)

  10. CMDT E.G.M. ALEXANDER, CMDT G.K.B. BARREN AND CDR A.A. ...

    African Journals Online (AJOL)

    CMDT E.G.M. ALEXANDER, CMDT G.K.B.. BARREN AND CDR A.A. BATEMAN: SOUTH. AFRICAN ORDERS DECORATIONS AND. MEDALS (160pp). This book was written by authors representing the SA Army, Air Force and Navy each an auth- ority in his field, and is the standard reference on the subject of South Africa's ...

  11. A ‘Social Form Of Knowledge’ in Practice: Unofficial Compiling of 1960s Pop Music on CD-R

    Directory of Open Access Journals (Sweden)

    Paul Martin

    2012-01-01

    Full Text Available In this article I explore the ‘unofficial’ (and technically illegal compiling of marginally known 1960s pop records on Compact Disc Recordable (CD-R. I do so by situating it within the proposition by the late Raphael Samuel, that history is ‘social knowledge’ and a practice rather than a profession. I propose that this compiling activity exemplifies this proposition. The core of the paper is centred on a 2007 survey which I conducted via three on-line 1960s music enthusiast discussion forums. I draw on the sixteen responses to demonstrate how the motivations, values and intentions of those respondents engaging in the practice of CD-R compiling are historically and socially centred. In doing so, I seek to problematise the music industry’s undifferentiated condemnation of all copying as theft. I do so by showing how, far from stealing, these CD-R compilers are adding to the musical social knowledge of 1960s pop and rock music. I further situate them within a longer lineage of ‘unofficial listening’ dating back to at least the 1930s. In using the term ‘unofficial’ in both a legal and public historical sense (eg to take issue with a received narrative, I point to wider definitions of what historically has or has not been musically ‘official’ to listen to. I seek also to point to the practice of CD-R compiling as a historical ‘moment’ in technological change, which might otherwise go unremarked upon as the CD-R itself heads towards utilitarian obsolescence. Although, the issues and concepts raised in the paper can be little more than pointed to, it is hoped it might act as one platform for the historical engagement with a subject more commonly discussed in sociological terms. As public historians we should be reflexive and inter-disciplinary and it is with this mind set that this article is written.

  12. Task 16 -- Sampling and analysis at the Vortec vitrification facility in Paducah, Kentucky. Semi-annual report, April 1--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Laudal, D.L.; Lilemoen, C.M.; Hurley, J.P.; Ness, S.R.; Stepan, D.J.; Thompson, J.S.

    1997-05-01

    The Vortec Cyclone Melting System (CMS{reg_sign}) facility, to be located at the US Department of Energy (DOE) Paducah Gaseous Diffusion Plant, is designed to treat soil contaminated with low levels of heavy metals and radioactive elements, as well as organic waste. To assure that costs of sampling and analysis are contained, Vortec and the DOE Federal Energy Technology Center (FETC) have decided that initially the primary focus of the sampling activities will be on meeting permitting requirements of the state of Kentucky. Therefore, sampling will be limited to the feedstock entering the system, and the glass, flue gas, and water leaving the system. The authors provide suggestions for optional sampling points and procedures in case there is later interest in operations or mass balance data. The permits do not require speciation of the materials in the effluents, only opacity, total radioactivity, total particulate, and total HCl emissions for the gaseous emissions and total radioactivity in the water and solid products. In case future testing to support operations or mass balances is required, the authors include in this document additional information on the analyses of some species of interest. They include heavy metals (RCRA [Resource Conservation and Recovery Act] and Cu and Ni), radionuclides (Th{sub 230}, U{sub 235}, Tc{sup 99}, Cs{sup 137}, and Pu{sup 239}), and dioxins/furans.

  13. Applicable or relevant and appropriate requirements (ARARs) for remedial actions at the Paducah Gaseous Diffusion Plant: A compendium of environmental laws and guidance. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Etnier, E.L.; Eaton, L.A. [Oak Ridge National Lab., TN (United States)

    1992-03-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances found at sites placed on the National Priorities List (NPL) by the US Environmental Protection Agency (EPA) must comply with applicable or relevant and appropriate requirements (ARARs) or standards under federal and state environmental laws. To date, the US Department of Energy (DOE) Paducah Gaseous Diffusion Plant (PGDP) has not been on the NPL. Although DOE and EPA have entered into an Administrative Consent Order (ACO), the prime regulatory authority for cleanup at PGDP will be the Resource Conservation and Recovery Act (RCRA). This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at PGDP in the event that the plant becomes included on the NPL or the ACO is modified to include CERCLA cleanup. A description of the terms ``applicable`` and ``relevant and appropriate`` is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Kentucky are listed in tables. In addition, the major provisions of RCRA, the Safe Drinking Water Act, the Clean Water Act, the Clean Air Act, and other acts, as they apply to hazardous and radioactive waste cleanup, are discussed.

  14. Applicable or relevant and appropriate requirements (ARARs) for remedial actions at the Paducah Gaseous Diffusion Plant: A compendium of environmental laws and guidance

    Energy Technology Data Exchange (ETDEWEB)

    Etnier, E.L.; Eaton, L.A. (Oak Ridge National Lab., TN (United States))

    1992-03-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances found at sites placed on the National Priorities List (NPL) by the US Environmental Protection Agency (EPA) must comply with applicable or relevant and appropriate requirements (ARARs) or standards under federal and state environmental laws. To date, the US Department of Energy (DOE) Paducah Gaseous Diffusion Plant (PGDP) has not been on the NPL. Although DOE and EPA have entered into an Administrative Consent Order (ACO), the prime regulatory authority for cleanup at PGDP will be the Resource Conservation and Recovery Act (RCRA). This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at PGDP in the event that the plant becomes included on the NPL or the ACO is modified to include CERCLA cleanup. A description of the terms applicable'' and relevant and appropriate'' is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Kentucky are listed in tables. In addition, the major provisions of RCRA, the Safe Drinking Water Act, the Clean Water Act, the Clean Air Act, and other acts, as they apply to hazardous and radioactive waste cleanup, are discussed.

  15. Applicable or relevant and appropriate requirements (ARARs) for remedial actions at the Paducah Gaseous Diffusion Plant: A compendium of environmental laws and guidance

    International Nuclear Information System (INIS)

    Etnier, E.L.; Eaton, L.A.

    1992-03-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances found at sites placed on the National Priorities List (NPL) by the US Environmental Protection Agency (EPA) must comply with applicable or relevant and appropriate requirements (ARARs) or standards under federal and state environmental laws. To date, the US Department of Energy (DOE) Paducah Gaseous Diffusion Plant (PGDP) has not been on the NPL. Although DOE and EPA have entered into an Administrative Consent Order (ACO), the prime regulatory authority for cleanup at PGDP will be the Resource Conservation and Recovery Act (RCRA). This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at PGDP in the event that the plant becomes included on the NPL or the ACO is modified to include CERCLA cleanup. A description of the terms ''applicable'' and ''relevant and appropriate'' is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Kentucky are listed in tables. In addition, the major provisions of RCRA, the Safe Drinking Water Act, the Clean Water Act, the Clean Air Act, and other acts, as they apply to hazardous and radioactive waste cleanup, are discussed

  16. CHANGING THE LANDSCAPE--LOW-TECH SOLUTIONS TO THE PADUCAH SCRAP METAL REMOVAL PROJECT ARE PROVIDING SAFE, COST-EFFECTIVE REMEDIATION OF CONTAMINATED SCRAP YARDS

    International Nuclear Information System (INIS)

    Watson, Dan; Eyman, Jeff

    2003-01-01

    Between 1974 and 1983, contaminated equipment was removed from the Paducah Gaseous Diffusion Plant (PGDP) process buildings as part of an enrichment process upgrade program. The upgrades consisted of the dismantlement, removal, and on-site storage of contaminated equipment, cell components, and scrap material (e.g., metal) from the cascade facilities. Scrap metal including other materials (e.g., drums, obsolete equipment) not related to this upgrade program have thus far accumulated in nine contiguous radiologically-contaminated and non-contaminated scrap yards covering 1.05E5 m2 (26 acres) located in the northwestern portion of the PGDP. This paper presents the sequencing of field operations and methods used to achieve the safe removal and disposition of over 47,000 tonnes (53,000 tons) of metal and miscellaneous items contained in these yards. The methods of accomplishment consist of mobilization, performing nuclear criticality safety evaluations, moving scrap metal to ground level, inspection and segregation, sampling and characterization, scrap metal sizing, packaging and disposal, and finally demobilization. Preventing the intermingling of characteristically hazardous and non-hazardous wastes promotes waste minimization, allowing for the metal and materials to be segregated into 13 separate waste streams. Low-tech solutions such as using heavy equipment to retrieve, size, and package scrap materials in conjunction with thorough planning that integrates safe work practices, commitment to teamwork, and incorporating lessons learned ensures that field operations will be conducted efficiently and safely

  17. Task 16 -- Sampling and analysis at the Vortec vitrification facility in Paducah, Kentucky. Semi-annual report, April 1--September 30, 1997

    International Nuclear Information System (INIS)

    Laudal, D.L.; Lilemoen, C.M.; Hurley, J.P.; Ness, S.R.; Stepan, D.J.; Thompson, J.S.

    1997-05-01

    The Vortec Cyclone Melting System (CMS reg-sign) facility, to be located at the US Department of Energy (DOE) Paducah Gaseous Diffusion Plant, is designed to treat soil contaminated with low levels of heavy metals and radioactive elements, as well as organic waste. To assure that costs of sampling and analysis are contained, Vortec and the DOE Federal Energy Technology Center (FETC) have decided that initially the primary focus of the sampling activities will be on meeting permitting requirements of the state of Kentucky. Therefore, sampling will be limited to the feedstock entering the system, and the glass, flue gas, and water leaving the system. The authors provide suggestions for optional sampling points and procedures in case there is later interest in operations or mass balance data. The permits do not require speciation of the materials in the effluents, only opacity, total radioactivity, total particulate, and total HCl emissions for the gaseous emissions and total radioactivity in the water and solid products. In case future testing to support operations or mass balances is required, the authors include in this document additional information on the analyses of some species of interest. They include heavy metals (RCRA [Resource Conservation and Recovery Act] and Cu and Ni), radionuclides (Th 230 , U 235 , Tc 99 , Cs 137 , and Pu 239 ), and dioxins/furans

  18. Thermal Discharges from Paducah Gaseous Diffusion Plant Outfalls: Impacts on Stream Temperatures and Fauna of Little Bayou and Big Bayou Creeks

    International Nuclear Information System (INIS)

    Roy, W.K.

    1999-01-01

    The development of a biological monitoring plan for the receiving streams of the Paducah Gaseous Diffusion Plant (PGDP) began in the late 1980s, because of an Agreed Order (AO) issued in September 1987 by the Kentucky Division of Water (KDOW). Five years later, in September 1992, more stringent effluent limitations were imposed upon the PGDP operations when the KDOW reissued Kentucky Pollutant Discharge Elimination System permit No. KY 0004049. This action prompted the US Department of Energy (DOE) to request a stay of certain limits contained in the permit. An AO is being negotiated between KDOW, the United States Enrichment Corporation (USEC), and DOE that will require that several studies be conducted, including this stream temperature evaluation study, in an effort to establish permit limitations. All issues associated with this AO have been resolved, and the AO is currently being signed by all parties involved. The proposed effluent temperature limit is 89 F (31.7C) as a mean monthly temperature. In the interim, temperatures are not to exceed 95 F (35 C) as a monthly mean or 100 F (37.8 C) as a daily maximum. This study includes detailed monitoring of instream temperatures, benthic macroinvertebrate communities, fish communities, and a laboratory study of thermal tolerances

  19. Thermal discharges from Paducah Gaseous Diffusion Plant outfalls: Impacts on stream temperatures and fauna of Little Bayou and Big Bayou Creeks

    International Nuclear Information System (INIS)

    Roy, W.K.; Ryon, M.G.; Hinzman, R.L.

    1996-03-01

    The development of a biological monitoring plan for the receiving streams of the Paducah Gaseous Diffusion Plant (PGDP) began in the late 1980s, because of an Agreed Order (AO) issued in September 1987 by the Kentucky Division of Water (KDOW). Five years later, in September 1992, more stringent effluent limitations were imposed upon the PGDP operations when the KDOW reissued Kentucky Pollutant Discharge Elimination System permit No. KY 0004049. This action prompted the US Department of Energy (DOE) to request a stay of certain limits contained in the permit. An AO is being negotiated between KDOW, the US Enrichment Corporation (USEC), and DOE that will require that several studies be conducted, including this stream temperature evaluation study, in an effort to establish permit limitations. All issues associated with this AO have been resolved, and the AO is currently being signed by all parties involved. The proposed effluent temperature limit is 89 F (31.7 C) as a mean monthly temperature. In the interim, temperatures are not to exceed 95 F (35 C) as a monthly mean or 100 F (37.8 C) as a daily maximum. This study includes detailed monitoring of instream temperatures, benthic macroinvertebrate communities, fish communities, and a laboratory study of thermal tolerances

  20. Thermal Discharges from Paducah Gaseous Diffusion Plant Outfalls: Impacts on Stream Temperatures and Fauna of Little Bayou and Big Bayou Creeks

    Energy Technology Data Exchange (ETDEWEB)

    Roy, W.K.

    1999-01-01

    The development of a biological monitoring plan for the receiving streams of the Paducah Gaseous Diffusion Plant (PGDP) began in the late 1980s, because of an Agreed Order (AO) issued in September 1987 by the Kentucky Division of Water (KDOW). Five years later, in September 1992, more stringent effluent limitations were imposed upon the PGDP operations when the KDOW reissued Kentucky Pollutant Discharge Elimination System permit No. KY 0004049. This action prompted the US Department of Energy (DOE) to request a stay of certain limits contained in the permit. An AO is being negotiated between KDOW, the United States Enrichment Corporation (USEC), and DOE that will require that several studies be conducted, including this stream temperature evaluation study, in an effort to establish permit limitations. All issues associated with this AO have been resolved, and the AO is currently being signed by all parties involved. The proposed effluent temperature limit is 89 F (31.7C) as a mean monthly temperature. In the interim, temperatures are not to exceed 95 F (35 C) as a monthly mean or 100 F (37.8 C) as a daily maximum. This study includes detailed monitoring of instream temperatures, benthic macroinvertebrate communities, fish communities, and a laboratory study of thermal tolerances.

  1. Thermal discharges from Paducah Gaseous Diffusion Plant outfalls: Impacts on stream temperatures and fauna of Little Bayou and Big Bayou Creeks

    Energy Technology Data Exchange (ETDEWEB)

    Roy, W.K.; Ryon, M.G.; Hinzman, R.L. [Oak Ridge National Lab., TN (United States). Computer Science and Mathematics Div.

    1996-03-01

    The development of a biological monitoring plan for the receiving streams of the Paducah Gaseous Diffusion Plant (PGDP) began in the late 1980s, because of an Agreed Order (AO) issued in September 1987 by the Kentucky Division of Water (KDOW). Five years later, in September 1992, more stringent effluent limitations were imposed upon the PGDP operations when the KDOW reissued Kentucky Pollutant Discharge Elimination System permit No. KY 0004049. This action prompted the US Department of Energy (DOE) to request a stay of certain limits contained in the permit. An AO is being negotiated between KDOW, the US Enrichment Corporation (USEC), and DOE that will require that several studies be conducted, including this stream temperature evaluation study, in an effort to establish permit limitations. All issues associated with this AO have been resolved, and the AO is currently being signed by all parties involved. The proposed effluent temperature limit is 89 F (31.7 C) as a mean monthly temperature. In the interim, temperatures are not to exceed 95 F (35 C) as a monthly mean or 100 F (37.8 C) as a daily maximum. This study includes detailed monitoring of instream temperatures, benthic macroinvertebrate communities, fish communities, and a laboratory study of thermal tolerances.

  2. Increased Suicide Risk among Workers following Toxic Metal Exposure at the Paducah Gaseous Diffusion Plant From 1952 to 2003: A Cohort Study

    Directory of Open Access Journals (Sweden)

    LW Figgs

    2011-09-01

    Full Text Available Background: Suicide is a problem worldwide and occupation is an important risk factor. In the last decade, 55 200 deaths in the US were attributed to occupational risk factors. Objective: To determine if toxic metal exposure was associated with suicide risk among Paducah gaseous diffusion plant (PGDP workers. Methods: We assembled a cohort of 6820 nuclear industry workers employed from 1952 to 2003. A job-specific exposure matrix (JEM was used to determine metal exposure likelihood. Uranium exposure was also assessed by urinalysis. All suicide/self-injury International Classification for Disease (ICD codes were used to identify suicides. Standardized mortality ratios (SMR, odds ratios (OR, and hazard ratios (HR were used to estimate suicide risk. Results: PGDP suicide victims typically were younger white men. Within exposure likelihood categories, several suicide SMRs were typically elevated for several metals. Only beryllium exposure likelihood was associated with an increased HR. Uranium urine concentration was associated with an elevated suicide risk after stratification by urinalysis frequency. Conclusion: Suicide risk is associated with uranium exposure.

  3. Increased suicide risk among workers following toxic metal exposure at the Paducah gaseous diffusion plant from 1952 to 2003: a cohort study.

    Science.gov (United States)

    Figgs, L W; Holsinger, H; Freitas, S J; Brion, G M; Hornung, R W; Rice, C H; Tollerud, D

    2011-10-01

    Suicide is a problem worldwide and occupation is an important risk factor. In the last decade, 55 200 deaths in the US were attributed to occupational risk factors. To determine if toxic metal exposure was associated with suicide risk among Paducah gaseous diffusion plant (PGDP) workers. We assembled a cohort of 6820 nuclear industry workers employed from 1952 to 2003. A job-specific exposure matrix (JEM) was used to determine metal exposure likelihood. Uranium exposure was also assessed by urinalysis. All suicide/self-injury International Classification for Disease (ICD) codes were used to identify suicides. Standardized mortality ratios (SMR), odds ratios (OR), and hazard ratios (HR) were used to estimate suicide risk. PGDP suicide victims typically were younger white men. Within exposure likelihood categories, several suicide SMRs were typically elevated for several metals. Only beryllium exposure likelihood was associated with an increased HR. Uranium urine concentration was associated with an elevated suicide risk after stratification by urinalysis frequency. Suicide risk is associated with uranium exposure.

  4. Streamflow, specific-conductance, and temperature data for Bayou and Little Bayou Creeks near Paducah, Kentucky, August 15 and 16, 1989

    Science.gov (United States)

    Evaldi, R.D.; McClain, D.L.

    1989-01-01

    Discharge, temperature, and specific conductance measurements were made August 15 and 16, 1989, at 74 main channel sites and seven flowing tributaries on Bayou and Little Bayou Creeks, Kentucky in the vicinity of the Paducah Gaseous Diffusion Plant. These measurements were made during base flow conditions to provide data for analysis of the interaction of surface and groundwater. The discharge of Bayou Creek was 0.30 cfs at the most upstream site, and 5.8 cfs at the most downstream site. Total measured tributary inflow of Bayou Creek was 5.7 cfs. Specific conductance values in the Bayou Creek watershed ranged from 208 to 489 microsiemens/cm, and water temperature ranged from 20.0 to 32.6 C. The discharge of Little Bayou Creek was 0.65 cfs at the most upstream site, and 1.8 cfs at the most downstream site. Total measured tributary inflow of Little Bayou Creek was 0.38 cfs. Specific conductance values in the Little Bayou Creek watershed ranged from 211 to 272 microsiemens/cm, and water temperature ranged from 14.5 to 24.9 C. (USGS)

  5. NOAA Climate Data Record (CDR) of Reflectance and Brightness Temperatures from AVHRR Pathfinder Atmospheres - Extended (PATMOS-x), Version 5.3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of AVHRR reflectance and brightness temperatures was produced by the University of Wisconsin using the AVHRR Pathfinder...

  6. NOAA Climate Data Record (CDR) of GPS RO-Calibrated AMSU Channel 7 (Temperatures of Troposphere / Stratosphere, TTS), Version 1.0 (Version Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Climate Data Records (CDR) for Channel 7 contains Radio Occulation (RO) calibrated brightness temperatures from AMSU-A channel 7 measurements at 54.9 GHz from...

  7. NOAA Climate Data Record (CDR) of AVHRR Daily and Monthly Aerosol Optical Thickness (AOT) over Global Oceans, Version 3.0

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The product is the aerosol optical thickness (AOT) at 0.63 micron, which is retrieved from NOAA PATMOS-x level-2B orbital radinace and cloud CDR products. The...

  8. NOAA Climate Data Record (CDR) of Intersatellite Calibrated Clear-Sky HIRS Channel 12 Brightness Temperature, Version 2.6 (Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of Inter-Satellite Calibrated Clear-Sky High Resolution Infrared Radiation Sounder (HIRS) Channel 12 brightness temperatures...

  9. Expression of cold and drought regulatory protein (CcCDR) of pigeonpea imparts enhanced tolerance to major abiotic stresses in transgenic rice plants.

    Science.gov (United States)

    Sunitha, Mellacheruvu; Srinath, Tamirisa; Reddy, Vudem Dashavantha; Rao, Khareedu Venkateswara

    2017-06-01

    Transgenic rice expressing pigeonpea Cc CDR conferred high-level tolerance to different abiotic stresses. The multiple stress tolerance observed in CcCDR -transgenic lines is attributed to the modulation of ABA-dependent and-independent signalling-pathway genes. Stable transgenic plants expressing Cajanus cajan cold and drought regulatory protein encoding gene (CcCDR), under the control of CaMV35S and rd29A promoters, have been generated in indica rice. Different transgenic lines of CcCDR, when subjected to drought, salt, and cold stresses, exhibited higher seed germination, seedling survival rates, shoot length, root length, and enhanced plant biomass when compared with the untransformed control plants. Furthermore, transgenic plants disclosed higher leaf chlorophyll content, proline, reducing sugars, SOD, and catalase activities, besides lower levels of MDA. Localization studies revealed that the CcCDR-GFP fusion protein was mainly present in the nucleus of transformed cells of rice. The CcCDR transgenics were found hypersensitive to abscisic acid (ABA) and showed reduced seed germination rates as compared to that of control plants. When the transgenic plants were exposed to drought and salt stresses at vegetative and reproductive stages, they revealed larger panicles and higher number of filled grains compared to the untransformed control plants. Under similar stress conditions, the expression levels of P5CS, bZIP, DREB, OsLEA3, and CIPK genes, involved in ABA-dependent and-independent signal transduction pathways, were found higher in the transgenic plants than the control plants. The overall results amply demonstrate that the transgenic rice expressing CcCDR bestows high-level tolerance to drought, salt, and cold stress conditions. Accordingly, the CcCDR might be deployed as a promising candidate gene for improving the multiple stress tolerance of diverse crop plants.

  10. A Climate Data Record (CDR for the global terrestrial water budget: 1984–2010

    Directory of Open Access Journals (Sweden)

    Y. Zhang

    2018-01-01

    Full Text Available Closing the terrestrial water budget is necessary to provide consistent estimates of budget components for understanding water resources and changes over time. Given the lack of in situ observations of budget components at anything but local scale, merging information from multiple data sources (e.g., in situ observation, satellite remote sensing, land surface model, and reanalysis through data assimilation techniques that optimize the estimation of fluxes is a promising approach. Conditioned on the current limited data availability, a systematic method is developed to optimally combine multiple available data sources for precipitation (P, evapotranspiration (ET, runoff (R, and the total water storage change (TWSC at 0.5° spatial resolution globally and to obtain water budget closure (i.e., to enforce P − ET − R − TWSC =  0 through a constrained Kalman filter (CKF data assimilation technique under the assumption that the deviation from the ensemble mean of all data sources for the same budget variable is used as a proxy of the uncertainty in individual water budget variables. The resulting long-term (1984–2010, monthly 0.5° resolution global terrestrial water cycle Climate Data Record (CDR data set is developed under the auspices of the National Aeronautics and Space Administration (NASA Earth System Data Records (ESDRs program. This data set serves to bridge the gap between sparsely gauged regions and the regions with sufficient in situ observations in investigating the temporal and spatial variability in the terrestrial hydrology at multiple scales. The CDR created in this study is validated against in situ measurements like river discharge from the Global Runoff Data Centre (GRDC and the United States Geological Survey (USGS, and ET from FLUXNET. The data set is shown to be reliable and can serve the scientific community in understanding historical climate variability in water cycle fluxes and stores, benchmarking

  11. A Climate Data Record (CDR) for the global terrestrial water budget: 1984–2010

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yu; Pan, Ming; Sheffield, Justin; Siemann, Amanda L.; Fisher, Colby K.; Liang, Miaoling; Beck, Hylke E.; Wanders, Niko; MacCracken, Rosalyn F.; Houser, Paul R.; Zhou, Tian; Lettenmaier, Dennis P.; Pinker, Rachel T.; Bytheway, Janice; Kummerow, Christian D.; Wood, Eric F.

    2018-01-01

    Closing the terrestrial water budget is necessary to provide consistent estimates of budget components for understanding water resources and changes over time. Given the lack of in situ observations of budget components at anything but local scale, merging information from multiple data sources (e.g., in situ observation, satellite remote sensing, land surface model, and reanalysis) through data assimilation techniques that optimize the estimation of fluxes is a promising approach. Conditioned on the current limited data availability, a systematic method is developed to optimally combine multiple available data sources for precipitation (P), evapotranspiration (ET), runoff (R), and the total water storage change (TWSC) at 0.5° spatial resolution globally and to obtain water budget closure (i.e., to enforce P-ET-R-TWSC = 0) through a constrained Kalman filter (CKF) data assimilation technique under the assumption that the deviation from the ensemble mean of all data sources for the same budget variable is used as a proxy of the uncertainty in individual water budget variables. The resulting long-term (1984–2010), monthly 0.5° resolution global terrestrial water cycle Climate Data Record (CDR) data set is developed under the auspices of the National Aeronautics and Space Administration (NASA) Earth System Data Records (ESDRs) program. This data set serves to bridge the gap between sparsely gauged regions and the regions with sufficient in situ observations in investigating the temporal and spatial variability in the terrestrial hydrology at multiple scales. The CDR created in this study is validated against in situ measurements like river discharge from the Global Runoff Data Centre (GRDC) and the United States Geological Survey (USGS), and ET from FLUXNET. The data set is shown to be reliable and can serve the scientific community in understanding historical climate variability in water cycle fluxes and stores, benchmarking the

  12. A Climate Data Record (CDR) for the global terrestrial water budget: 1984-2010

    Science.gov (United States)

    Zhang, Yu; Pan, Ming; Sheffield, Justin; Siemann, Amanda L.; Fisher, Colby K.; Liang, Miaoling; Beck, Hylke E.; Wanders, Niko; MacCracken, Rosalyn F.; Houser, Paul R.; Zhou, Tian; Lettenmaier, Dennis P.; Pinker, Rachel T.; Bytheway, Janice; Kummerow, Christian D.; Wood, Eric F.

    2018-01-01

    Closing the terrestrial water budget is necessary to provide consistent estimates of budget components for understanding water resources and changes over time. Given the lack of in situ observations of budget components at anything but local scale, merging information from multiple data sources (e.g., in situ observation, satellite remote sensing, land surface model, and reanalysis) through data assimilation techniques that optimize the estimation of fluxes is a promising approach. Conditioned on the current limited data availability, a systematic method is developed to optimally combine multiple available data sources for precipitation (P), evapotranspiration (ET), runoff (R), and the total water storage change (TWSC) at 0.5° spatial resolution globally and to obtain water budget closure (i.e., to enforce P - ET - R - TWSC = 0) through a constrained Kalman filter (CKF) data assimilation technique under the assumption that the deviation from the ensemble mean of all data sources for the same budget variable is used as a proxy of the uncertainty in individual water budget variables. The resulting long-term (1984-2010), monthly 0.5° resolution global terrestrial water cycle Climate Data Record (CDR) data set is developed under the auspices of the National Aeronautics and Space Administration (NASA) Earth System Data Records (ESDRs) program. This data set serves to bridge the gap between sparsely gauged regions and the regions with sufficient in situ observations in investigating the temporal and spatial variability in the terrestrial hydrology at multiple scales. The CDR created in this study is validated against in situ measurements like river discharge from the Global Runoff Data Centre (GRDC) and the United States Geological Survey (USGS), and ET from FLUXNET. The data set is shown to be reliable and can serve the scientific community in understanding historical climate variability in water cycle fluxes and stores, benchmarking the current climate, and

  13. Stakeholders' opinions on the implementation of Child Death Review in the Netherlands.

    Science.gov (United States)

    Gijzen, Sandra; L'Hoir, Monique P; Boere-Boonekamp, Magda M; Need, Ariana

    2016-04-21

    The death of a child is an enormous tragedy for both the family and others involved. A child's death appeals to everyone's responsibility to take measures to prevent similar deaths in the future. Child Death Review (CDR) is an interagency approach in which a child's death is systematically analyzed by a multidisciplinary team. The aim of CDR is to identify avoidable factors that give direction to prevention and to improve death statistics. CDR is not yet implemented in the Netherlands. The purpose of this study is to determine Dutch stakeholders' opinions regarding the facilitating and impeding factors in the implementation of CDR in the Netherlands. Four focus groups were conducted: three with professionals who are involved in children's deaths and one with parents who have lost a child under the age of 2 years. The recorded discussions were transcribed and analyzed using Atlas ti. The facilitating and impeding factors were measured using the measurement instrument for determinants of innovations (MIDI). The MIDI identifies facilitating and impeding determinants associated with the innovation, user, organization and social-political context. Improvement of the quality of (health) care and obtaining a clear explanation for the child's death (user and innovation) were identified as benefits of CDR. The emotional burden for professionals and parents and the time implications were considered to be drawbacks of CDR (user and innovation). The multidisciplinary approach (innovation), parental consent and the use of anonimyzed data (user) were considered as facilitators to implementation. Insufficient information (innovation), potential legal consequences for professionals and organizations (user), insufficient ratification by organizations (organization) and confidentiality (social-political context) were identified as impeding implementation. The determinants identified as facilitating and the recommendations provided to overcome the barriers can be used as input for

  14. JOPATW~1.cdr 08.cdr

    African Journals Online (AJOL)

    tablets, the mechanism and kinetics of drug delivery were studied. Aminophyline was the prototype ... The mechanism of release of aminophyline from ADM as in Cp and HPMC was by diffusion. Key words: Adansonia .... cohesive and adhesive forces between polymerspolymer and polymer-drug or lactose particles (14).

  15. JOPATW~1.cdr 08.cdr

    African Journals Online (AJOL)

    were conducted among the traditional medical practitioners and herbal traders in both urban and rural areas of the state. ..... 1N. Araliaceae. 193. Cussonia arborea Hochst ex. A.Rich. (Syn:.Cussonia barteri). Barters cussunia,. Cork – bark tree. Kpawu/Efokoci (N), Takandargiwa. (H), Shigo (Y) sb;m. 1N. Asclepiaceae. 369.

  16. JOPATW~1.cdr 08.cdr

    African Journals Online (AJOL)

    HIV serial and parallel serologic testing algorithms in Abidjan, Côte d'Ivoire. AIDS 13:109-. 117. 10. Palmer, C. J., J. M. Dubon, E. Koenig, E. Perez, A. Ager, D. Jayaweera, R. R. Cuadrado, A. Rivera, A. Rubido, and D. A. Palmer (1999): Field evaluation of the Determine rapid human immunodeficiency virus diagnostic test in ...

  17. Overcoming the heterologous bias: An in vivo functional analysis of multidrug efflux transporter, CgCdr1p in matched pair clinical isolates of Candida glabrata

    Energy Technology Data Exchange (ETDEWEB)

    Puri, Nidhi; Manoharlal, Raman; Sharma, Monika [Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067 (India); Sanglard, Dominique [Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne (Switzerland); Prasad, Rajendra, E-mail: rp47jnu@gmail.com [Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067 (India)

    2011-01-07

    Research highlights: {yields} First report to demonstrate an in vivo expression system of an ABC multidrug transporter CgCdr1p of C. glabrata. {yields} First report on the structure and functional characterization of CgCdr1p. {yields} Functional conservation of divergent but typical residues of CgCdr1p. {yields} CgCdr1p elicits promiscuity towards substrates and has a large drug binding pocket with overlapping specificities. -- Abstract: We have taken advantage of the natural milieu of matched pair of azole sensitive (AS) and azole resistant (AR) clinical isolates of Candida glabrata for expressing its major ABC multidrug transporter, CgCdr1p for structure and functional analysis. This was accomplished by tagging a green fluorescent protein (GFP) downstream of ORF of CgCDR1 and integrating the resultant fusion protein at its native chromosomal locus in AS and AR backgrounds. The characterization confirmed that in comparison to AS isolate, CgCdr1p-GFP was over-expressed in AR isolates due to its hyperactive native promoter and the GFP tag did not affect its functionality in either construct. We observed that in addition to Rhodamine 6 G (R6G) and Fluconazole (FLC), a recently identified fluorescent substrate of multidrug transporters Nile Red (NR) could also be expelled by CgCdr1p. Competition assays with these substrates revealed the presence of overlapping multiple drug binding sites in CgCdr1p. Point mutations employing site directed mutagenesis confirmed that the role played by unique amino acid residues critical to ATP catalysis and localization of ABC drug transporter proteins are well conserved in C. glabrata as in other yeasts. This study demonstrates a first in vivo novel system where over-expression of GFP tagged MDR transporter protein can be driven by its own hyperactive promoter of AR isolates. Taken together, this in vivo system can be exploited for the structure and functional analysis of CgCdr1p and similar proteins wherein the arte-factual concerns

  18. Using the NASA EOS A-Train to Probe the Performance of the NOAA PATMOS-x Cloud Fraction CDR

    Directory of Open Access Journals (Sweden)

    Andrew Heidinger

    2016-06-01

    Full Text Available An important component of the AVHRR PATMOS-x climate date record (CDR—or any satellite cloud climatology—is the performance of its cloud detection scheme and the subsequent quality of its cloud fraction CDR. PATMOS-x employs the NOAA Enterprise Cloud Mask for this, which is based on a naïve Bayesian approach. The goal of this paper is to generate analysis of the PATMOS-x cloud fraction CDR to facilitate its use in climate studies. Performance of PATMOS-x cloud detection is compared to that of the well-established MYD35 and CALIPSO products from the EOS A-Train. Results show the AVHRR PATMOS-x CDR compares well against CALIPSO with most regions showing proportional correct values of 0.90 without any spatial filtering and 0.95 when a spatial filter is applied. Values are similar for the NASA MODIS MYD35 mask. A direct comparison of PATMOS-x and MYD35 from 2003 to 2014 also shows agreement over most regions in terms of mean cloud amount, inter-annual variability, and linear trends. Regional and seasonal differences are discussed. The analysis demonstrates that PATMOS-x cloud amount uncertainty could effectively screen regions where PATMOS-x differs from MYD35.

  19. Evaluation of alternatives for best available technology treatment and retreatment of uranium-contaminated wastewater at the Paducah Gaseous Diffusion Plant C-400 Facility

    International Nuclear Information System (INIS)

    Del Cul, G.D.; Osborne, P.E.; Beck, D.E.

    1991-01-01

    The Paducah Gaseous Diffusion Plant (PGDP) C-400 Decontamination Facility generates aqueous solutions that originate in drum washing, machine parts and equipment cleaning, and other decontamination processes. The chemical composition of the waste depends on the particular operation involved. In general, the waste contains uranyl, fluoride, carbonate, and nitrate ions, plus soaps, detergents, secondary contaminants, and particulate matter. The uranium content is rather variable ranging between 0.5 and 30 g/l. The main contaminants are fluoride, technetium, uranium, and other heavy metals. The plan included (1) a literature search to support best available technology (BAT) evaluation of treatment alternatives, (2) a quality assurance/quality control plan, (3) suggestion of alternative treatment options, (4) bench-scale tests studies of the proposed treatment alternatives, and (5) establishment of the final recommendation. The following report records the evaluation of items (1) to (3) of the action plan for the BAT evaluation of alternatives for the treatment and retreatment of uranium-contaminated wastewater at the PGDP C-400 treatment facility. After a thorough literature search, five major technologies were considered: (1) precipitation/coprecipitation, (2) reverse osmosis, (3) ultrafiltration, (4) supported liquid membranes, and (5) ion exchange. Biosorption was also considered, but as it is a fairly new technology with few demonstrations of its capabilities, it is mentioned only briefly in the report. Based on C-400's requirements and facilities, the precipitation/coprecipitation process appears to be the best suited for use at the plant. Four different treatment options using the precipitation/coprecipitation technology are proposed. Bench-scale studies of the four options are suggested. 37 refs

  20. ECOSYSTEM IMPACTS OF GEOENGINEERING: A Review for Developing a Science Plan

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Lynn M.; Rasch, Philip J.; Mace, Georgina; Jackson, Robert B.; Shepherd, John; Liss, Peter; Leinen, Margaret; Schimel, David; Vaughan, Naomi E.; Janetos, Anthony C.; Boyd, Philip W.; Norby, Richard J.; Caldeira, Ken; Merikanto, Joonas; Artaxo, Paulo; Melillo, Jerry; Morgan, M. Granger

    2012-06-01

    Geoengineering methods are intended to reduce the magnitude of climate change. Climate change in some regions is already having demonstrable effects on ecosystem structure and functioning. Two different types of geoengineering activities have been proposed: carbon dioxide removal (CDR), which includes a range of engineered and biological processes to remove carbon dioxide (CO2) from the atmosphere, and solar radiation management (SRM, or sunlight reflection methods), whereby a small percentage of sunlight is reflected back into space to offset warming from greenhouse gases. In this review, we evaluate some of the possible impacts of CDR and SRM on the physical climate and their subsequent influence on ecosystems, including the risks and uncertainties associated with new kinds of purposeful perturbations to Earth. Specifically, we find evidence that, if implemented successfully, some CDR methods and continue use of some SRM methods) could alleviate some of the deleterious ecosystem impacts associated with climate changes that might occur in the foreseeable future.

  1. Stakeholders' opinions on the implementation of Child Death Review in the Netherlands

    NARCIS (Netherlands)

    Gijzen, S.; Hoir, M.P. L; Boere-Boonekamp, M.M.; Need, A.

    2016-01-01

    Background The death of a child is an enormous tragedy for both the family and others involved. A child’s death appeals to everyone’s responsibility to take measures to prevent similar deaths in the future. Child Death Review (CDR) is an interagency approach in which a child’s death is

  2. Stakeholders’ opinions on the implementation of Child Death Review in the Netherlands

    NARCIS (Netherlands)

    Knoeff-Gijzen, Sandra; L'Hoir, Monique P.; Boere-Boonekamp, Magdalena M.; Need, Ariana

    2016-01-01

    Background The death of a child is an enormous tragedy for both the family and others involved. A child’s death appeals to everyone’s responsibility to take measures to prevent similar deaths in the future. Child Death Review (CDR) is an interagency approach in which a child’s death is

  3. Procedures in child deaths in The Netherlands: a comparison with child death review

    NARCIS (Netherlands)

    Gijzen, S.; Petter, J.; L'Hoir, M.P.; Boere-Boonekamp, M.M.; Need, A.

    2017-01-01

    Aim: Child Death Review (CDR) is a method in which every child death is systematically and multidisciplinary examined to (1) improve death statistics, (2) identify factors that give direction for prevention, (3) translate the results into possible interventions, and (4) support families. The aim of

  4. ENZYME ACTIVITY PROBE AND GEOCHEMICAL ASSESSMENT FOR POTENTIAL AEROBIC COMETABOLISM OF TRICHLOROETHENE IN GROUNDWATER OF THE NORTHWEST PLUME, PADUCAH GASEOUS DIFFUSION PLANT, KENTUCKY

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B; M. Hope Lee, M; S. K. Hampson, S

    2008-06-27

    The overarching objective of the Paducah Gaseous Diffusion Plant (PGDP) enzyme activity probe (EAP) effort is to determine if aerobic cometabolism is contributing to the attenuation of trichloroethene (TCE) and other chlorinated solvents in the contaminated groundwater beneath PGDP. The site-specific objective for the EAP assessment is to identify if key metabolic pathways are present and expressed in the microbial community--namely the pathways that are responsible for degradation of methane and aromatic (e.g. toluene, benzene, phenol) substrates. The enzymes produced to degrade methane and aromatic compounds also break down TCE through a process known as cometabolism. EAPs directly measure if methane and/or aromatic enzyme production pathways are operating and, for the aromatic pathways, provide an estimate of the number of active organisms in the sampled groundwater. This study in the groundwater plumes at PGDP is a major part of a larger scientific effort being conducted by Interstate Technology and Regulatory Council (ITRC), U.S. Department of Energy (DOE) Office of Environmental Management (EM), Savannah River National Laboratory (SRNL), and North Wind Inc. in which EAPs are being applied to contaminated groundwater from diverse hydrogeologic and plume settings throughout the U.S. to help standardize their application as well as their interpretation. While EAP data provide key information to support the site specific objective for PGDP, several additional lines of evidence are being evaluated to increase confidence in the determination of the occurrence of biodegradation and the rate and sustainability of aerobic cometabolism. These complementary efforts include: (1) Examination of plume flowpaths and comparison of TCE behavior to 'conservative' tracers in the plume (e.g., {sup 99}Tc); (2) Evaluation of geochemical conditions throughout the plume; and (3) Evaluation of stable isotopes in the contaminants and their daughter products throughout the

  5. Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans.

    Science.gov (United States)

    Maurya, Indresh Kumar; Thota, Chaitanya Kumar; Verma, Sachin Dev; Sharma, Jyotsna; Rawal, Manpreet Kaur; Ravikumar, Balaguru; Sen, Sobhan; Chauhan, Neeraj; Lynn, Andrew M; Chauhan, Virander Singh; Prasad, Rajendra

    2013-06-07

    Drug-resistant pathogenic fungi use several families of membrane-embedded transporters to efflux antifungal drugs from the cells. The efflux pump Cdr1 (Candida drug resistance 1) belongs to the ATP-binding cassette (ABC) superfamily of transporters. Cdr1 is one of the most predominant mechanisms of multidrug resistance in azole-resistant (AR) clinical isolates of Candida albicans. Blocking drug efflux represents an attractive approach to combat the multidrug resistance of this opportunistic human pathogen. In this study, we rationally designed and synthesized transmembrane peptide mimics (TMPMs) of Cdr1 protein (Cdr1p) that correspond to each of the 12 transmembrane helices (TMHs) of the two transmembrane domains of the protein to target the primary structure of the Cdr1p. Several FITC-tagged TMPMs specifically bound to Cdr1p and blocked the efflux of entrapped fluorescent dyes from the AR (Gu5) isolate. These TMPMs did not affect the efflux of entrapped fluorescent dye from cells expressing the Cdr1p homologue Cdr2p or from cells expressing a non-ABC transporter Mdr1p. Notably, the time correlation of single photon counting fluorescence measurements confirmed the specific interaction of FITC-tagged TMPMs with their respective TMH. By using mutant variants of Cdr1p, we show that these TMPM antagonists contain the structural information necessary to target their respective TMHs of Cdr1p and specific binding sites that mediate the interactions between the mimics and its respective helix. Additionally, TMPMs that were devoid of any demonstrable hemolytic, cytotoxic, and antifungal activities chemosensitize AR clinical isolates and demonstrate synergy with drugs that further improved the therapeutic potential of fluconazole in vivo.

  6. Intercomparison of PERSIANN-CDR and TRMM-3B42V7 precipitation estimates at monthly and daily time scales

    Science.gov (United States)

    Katiraie-Boroujerdy, Pari-Sima; Akbari Asanjan, Ata; Hsu, Kuo-lin; Sorooshian, Soroosh

    2017-09-01

    In the first part of this paper, monthly precipitation data from Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks-Climate Data Record (PERSIANN-CDR) and Tropical Rainfall Measuring Mission 3B42 algorithm Version 7 (TRMM-3B42V7) are evaluated over Iran using the Generalized Three-Cornered Hat (GTCH) method which is self-sufficient of reference data as input. Climate Data Unit (CRU) is added to the GTCH evaluations as an independent gauge-based dataset thus, the minimum requirement of three datasets for the model is satisfied. To ensure consistency of all datasets, the two satellite products were aggregated to 0.5° spatial resolution, which is the minimum resolution of CRU. The results show that the PERSIANN-CDR has higher Signal to Noise Ratio (SNR) than TRMM-3B42V7 for the monthly rainfall estimation, especially in the northern half of the country. All datasets showed low SNR in the mountainous area of southwestern Iran, as well as the arid parts in the southeast region of the country. Additionally, in order to evaluate the efficacy of PERSIANN-CDR and TRMM-3B42V7 in capturing extreme daily-precipitation amounts, an in-situ rain-gauge dataset collected by the Islamic Republic of the Iran Meteorological Organization (IRIMO) was employed. Given the sparsity of the rain gauges, only 0.25° pixels containing three or more gauges were used for this evaluation. There were 228 such pixels where daily and extreme rainfall from PERSIANN-CDR and TRMM-3B42V7 could be compared. However, TRMM-3B42V7 overestimates most of the intensity indices (correlation coefficients; R between 0.7648-0.8311, Root Mean Square Error; RMSE between 3.29mm/day-21.2mm/5day); PERSIANN-CDR underestimates these extremes (R between 0.6349-0.7791 and RMSE between 3.59mm/day-30.56mm/5day). Both satellite products show higher correlation coefficients and lower RMSEs for the annual mean of consecutive dry spells than wet spells. The results show that TRMM-3B42V7

  7. Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport.

    Science.gov (United States)

    Baghel, Pratima; Rawal, Manpreet Kaur; Khan, Mohammad Firoz; Sen, Sobhan; Siddiqui, Mohammed Haris; Chaptal, Vincent; Falson, Pierre; Prasad, Rajendra

    2017-10-01

    The present study examines the kinetics of steroids efflux mediated by the Candida drug resistance protein 1 (Cdr1p) and evaluates their interaction with the protein. We exploited our in-house mutant library for targeting the 252 residues forming the twelve transmembrane helices (TMHs) of Cdr1p. The screening revealed 65 and 58 residues critical for β-estradiol and corticosterone transport, respectively. Notably, up to 83% critical residues for corticosterone face the lipid interface compared to 54% for β-estradiol. Molecular docking identified a possible peripheral corticosterone-binding site made of 8/14 critical/non-critical residues between TMHs 3, 4 and 6. β-estradiol transport was severely hampered by alanine replacements of Cdr1p core residues involving TMHs 2, 5 and 8, in a binding site made of 10/14 critical residues mainly shared with rhodamine 6G with which it competes. By contrast, TMH11 was poorly impacted, although being part of the core domain. Finally, we observed the presence of several contiguous stretches of 3-5 critical residues in TMHs 2, 5 and 10 that points to a rotation motion of these helices during the substrate transport cycle. The selective structural arrangement of the steroid-binding pockets in the core region and at the lipid-TMD interface, which was never reported before, together with the possible rotation of some TMHs may be the structural basis of the drug-transport mechanism achieved by these type II ABC transporters. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression.

    Directory of Open Access Journals (Sweden)

    Hai-Hua Geng

    Full Text Available Recent studies have demonstrated the role of Cdr1as (or CiRS-7, one of the well-identified circular RNAs (circRNAs, as a miR-7a/b sponge or inhibitor in brain tissues or islet cells. This study aimed to investigate the presence of Cdr1as/miR-7a pathway in cardiomyocytes, and explore the mechanism underlying the function of miR-7a in protecting against myocardial infarction (MI-induced apoptosis.Mouse MI injury model was established and evaluated by infarct size determination. Real-time PCR was performed to quantify the expression of Cdr1as and miR-7a in cardiomyocytes. Cell apoptosis was determined by caspase-3 activity analysis and flow cytometry assays with Annexin V/PI staining. Transfection of Cdr1as overexpressing plasmid and miR-7a mimic were conducted for gain-of-function studies. Luciferase reporter assay and western blot analysis were performed to verity potential miR-7a targets.Cdr1as and miR-7a were both upregulated in MI mice with increased cardiac infarct size, or cardiomyocytes under hypoxia treatment. Cdr1as overexpression in MCM cells promoted cell apoptosis, but was then reversed by miR-7a overexpression. The SP1 was identified as a new miR-7a target, in line with previously identified PARP, while miR-7a-induced decrease of cell apoptosis under hypoxia treatment was proven to be inhibited by PARP-SP1 overexpression. Moreover, Cdr1as overexpression in vivo increased cardiac infarct size with upregulated expression of PARP and SP1, while miR-7a overexpression reversed these changes.Cdr1as also functioned as a powerful miR-7a sponge in myocardial cells, and showed regulation on the protective role of miR-7a in MI injury, involving the function of miR-7a targets, PARP and SP1.

  9. Project W-519 CDR supplement: Raw water and electrical services for privatization contractor, AP tank farm operations

    International Nuclear Information System (INIS)

    Parazin, R.J.

    1998-01-01

    This supplement to the Project W-519 Conceptual Design will identify a means to provide RW and Electrical services to serve the needs of the TWRS Privatization Contractor (PC) at AP Tank Farm as directed by DOE-RL. The RW will serve the fire suppression and untreated process water requirements for the PC. The purpose of this CDR supplement is to identify Raw Water (RW) and Electrical service line routes to the TWRS Privatization Contractor (PC) feed delivery tanks, AP-106 and/or AP-108, and establish associated cost impacts to the Project W-519 baseline

  10. Project W-519 CDR supplement: Raw water and electrical services for privatization contractor, AP tank farm operations

    Energy Technology Data Exchange (ETDEWEB)

    Parazin, R.J.

    1998-07-31

    This supplement to the Project W-519 Conceptual Design will identify a means to provide RW and Electrical services to serve the needs of the TWRS Privatization Contractor (PC) at AP Tank Farm as directed by DOE-RL. The RW will serve the fire suppression and untreated process water requirements for the PC. The purpose of this CDR supplement is to identify Raw Water (RW) and Electrical service line routes to the TWRS Privatization Contractor (PC) feed delivery tanks, AP-106 and/or AP-108, and establish associated cost impacts to the Project W-519 baseline.

  11. Pre-clinical studies with CDR-grafted humanised anti-colorectal monoclonal antibody A33

    Energy Technology Data Exchange (ETDEWEB)

    Scott, A.M.; Lee, F.T.; Hutchinson, D.; Cebon, J. [Ludwig Inst. for Cancer Research, Austin Hospital, Heidelberg, VIC (Australia); Sturrock, S.; Pollock, D.; Armes, J.; Sinclair, R. [Austin Hospital, Heilderberg, VIC (Australia). Dept. of Anatomical Pathology; Welt, S.; Old, L.J. [Ludwig Inst. for Cancer Research, New York, NY (United States)

    1998-03-01

    Full text: Monoclonal antibodies (mAbs) can be raised to selected antigens preferentially expressed on cancer cells compared to normal tissues, and therefore have attractive properties for targeting of cancers for therapy. Numerous strategies can be employed for cell kill, including conjugation of isotopes or toxins, and utilisation of intrinsic immune effector function of mAbs. To date, immunogenicity of murine antibodies (HAMA) has been a major limitation in effectiveness of mAb therapy. The anticolorectal mAb A33 in its murine form has been studied in Phase l/ll trials. A CDR-grafted humanised versions of A33 (huA33) has been developed, and we are evaluating this for clinical trials. The intact mAb huA33 has been radiolabelled and shown to have retained immunoreactivity of 80% specific binding to SW-1222 colon cells (Ka of 1.4 x 10{sup -9} M). An F(ab``)2 fragment has been produced, and demonstrates similar affinity to the intact version with immunoreactivity of 74% specific binding, a Ka of 2 x 10{sup -9} M, and similar molar displacement by intact huA33 in in-vitro displacement assays. Immunohistochemistry with biotinylated huA33 has demonstrated similar normal tissue and colon cancer specificity to the murine A33. Biodistribution studies with {sup 125}I labelled huA33 and {sup 125}I-F(ab``)2 huA33 have been performed in SW-1222 xenografted balb-c nude mice, and have demonstrated excellent targeting to tumours with maximal tumour: blood and tumour: liver ratios ranging from 37:1 and 62:1, respectively. Clinical trials with intact and F(ab``)2 huA33 are planned based on the results of these pre-clinical studies.

  12. Pre-clinical studies with CDR-grafted humanised anti-colorectal monoclonal antibody A33

    International Nuclear Information System (INIS)

    Scott, A.M.; Lee, F.T.; Hutchinson, D.; Cebon, J.; Sturrock, S.; Pollock, D.; Armes, J.; Sinclair, R.

    1998-01-01

    Full text: Monoclonal antibodies (mAbs) can be raised to selected antigens preferentially expressed on cancer cells compared to normal tissues, and therefore have attractive properties for targeting of cancers for therapy. Numerous strategies can be employed for cell kill, including conjugation of isotopes or toxins, and utilisation of intrinsic immune effector function of mAbs. To date, immunogenicity of murine antibodies (HAMA) has been a major limitation in effectiveness of mAb therapy. The anticolorectal mAb A33 in its murine form has been studied in Phase l/ll trials. A CDR-grafted humanised versions of A33 (huA33) has been developed, and we are evaluating this for clinical trials. The intact mAb huA33 has been radiolabelled and shown to have retained immunoreactivity of 80% specific binding to SW-1222 colon cells (Ka of 1.4 x 10 -9 M). An F(ab'')2 fragment has been produced, and demonstrates similar affinity to the intact version with immunoreactivity of 74% specific binding, a Ka of 2 x 10 -9 M, and similar molar displacement by intact huA33 in in-vitro displacement assays. Immunohistochemistry with biotinylated huA33 has demonstrated similar normal tissue and colon cancer specificity to the murine A33. Biodistribution studies with 125 I labelled huA33 and 125 I-F(ab'')2 huA33 have been performed in SW-1222 xenografted balb-c nude mice, and have demonstrated excellent targeting to tumours with maximal tumour: blood and tumour: liver ratios ranging from 37:1 and 62:1, respectively. Clinical trials with intact and F(ab'')2 huA33 are planned based on the results of these pre-clinical studies

  13. Integration technique of digital I and C replacement and its Critical Digital Review procedure

    International Nuclear Information System (INIS)

    Huang, Hui-Wen; Yang, Wen-Long

    2013-01-01

    Highlights: ► A digital I and C replacement integration technique have been developed. ► Establishment of Nuclear Power Plant Digital Replacement Integration Guideline. ► Preliminary Investigation on I and C System Digitalization. ► Evaluation on I and C System Digitalization. ► Establishment of I and C System Digitalization Architectures. -- Abstract: Institute of Nuclear Energy Research (INER) developed a digital Instrumentation and Control (I and C) replacement integration technique on the basis of requirement of the three existing nuclear power plants (NPPs), which are Chin–Shan (CS) NPP, Kuo–Sheng (KS) NPP, and Maanshan (MS) NPP, in Taiwan, and also developed the related Critical Digital Review (CDR) procedure. The digital I and C replacement integration technique includes: (1) Establishment of Nuclear Power Plant Digital Replacement Integration Guideline, (2) Preliminary Investigation on I and C System Digitalization, (3) Evaluation on I and C System Digitalization, and (4) Establishment of I and C System Digitalization Architectures. These works can be a reference for performing I and C system digital replacement integration of the three existing NPPs of Taiwan Power Company (TPC). A CDR is the review for a critical system digital I and C replacement. The major reference of this procedure is EPRI TR-1011710 (2005) “Handbook for Evaluating Critical Digital Equipment and Systems” which was published by the Electric Power Research Institute (EPRI). With this document, INER developed a TPC-specific CDR procedure. Currently, CDR becomes one of the policies for digital I and C replacement in TPC. The contents of this CDR procedure include: Scope, Responsibility, Operation Procedure, Operation Flow Chart, CDR review items. The CDR review items include the comparison of the design change, Software Verification and Validation (SV and V), Failure Mode and Effects Analysis (FMEA), Evaluation of Diversity and Defense-in-depth (D3), Evaluation of

  14. Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity.

    Science.gov (United States)

    Chen, Xiaojing; Poncette, Lucia; Blankenstein, Thomas

    2017-11-06

    For thymic selection and responses to pathogens, T cells interact through their αβ T cell receptor (TCR) with peptide-major histocompatibility complex (MHC) molecules on antigen-presenting cells. How the diverse TCRs interact with a multitude of MHC molecules is unresolved. It is also unclear how humans generate larger TCR repertoires than mice do. We compared the TCR repertoire of CD4 T cells selected from a single mouse or human MHC class II (MHC II) in mice containing the human TCR gene loci. Human MHC II yielded greater thymic output and a more diverse TCR repertoire. The complementarity determining region 3 (CDR3) length adjusted for different inherent V-segment affinities to MHC II. Humans evolved with greater nontemplate-encoded CDR3 diversity than did mice. Our data, which demonstrate human TCR-MHC coevolution after divergence from rodents, explain the greater T cell diversity in humans and suggest a mechanism for ensuring that any V-J gene combination can be selected by a single MHC II. © 2017 Chen et al.

  15. A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition.

    Directory of Open Access Journals (Sweden)

    David Lutje Hulsik

    2013-03-01

    Full Text Available The membrane proximal external region (MPER of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies. We immunized llamas with gp41-MPER proteoliposomes and selected a MPER-specific single chain antibody (VHH, 2H10, whose epitope overlaps with that of mAb 2F5. Bi-2H10, a bivalent form of 2H10, which displayed an approximately 20-fold increased affinity compared to the monovalent 2H10, neutralized various sensitive and resistant HIV-1 strains, as well as SHIV strains in TZM-bl cells. X-ray and NMR analyses combined with mutagenesis and modeling revealed that 2H10 recognizes its gp41 epitope in a helical conformation. Notably, tryptophan 100 at the tip of the long CDR3 is not required for gp41 interaction but essential for neutralization. Thus bi-2H10 is an anti-MPER antibody generated by immunization that requires hydrophobic CDR3 determinants in addition to epitope recognition for neutralization similar to the mode of neutralization employed by mAbs 2F5 and 4E10.

  16. Systemic lupus erythematosus: molecular mimicry between anti-dsDNA CDR3 idiotype, microbial and self peptides as antigens for Th cells

    Directory of Open Access Journals (Sweden)

    Kristin eAas-Hanssen

    2015-07-01

    Full Text Available Systemic lupus erythematosus (SLE is marked by a T helper (Th cell dependent B cell hyperresponsiveness, with frequent germinal center reactions, and gammaglobulinemia. A hallmark of SLE is the finding of IgG autoantibodies specific for dsDNA. The specificity of the Th cells that drive the expansion of anti-dsDNA B cells is unresolved. However, anti-microbial, anti-histone and anti-idiotype Th cell responses have been hypothesized to play a role. It has been entirely unclear if these seemingly disparate Th cell responses and hypotheses could be related or unified. Here we describe that H chain CDR3 idiotypes from IgG+ B cells of lupus mice have sequence similarities with both microbial and other self peptides, matched sequences were increased within the mutated CDR3 repertoire and when sequences were derived from lupus mice with expanded anti-dsDNA B cells. Analyses of histone sequences showed that particular histone peptides were similar to VDJ junctions. Moreover, lupus mice had Th cell responses towards histone peptides similar to anti-dsDNA CDR3 sequences. The results suggest that Th cell in lupus may have multiple cross-reactive specificities linked to the IgVH CDR3 Id-peptide sequences as well as similar DNA-associated protein motifs.

  17. Comparison of GPM IMERG, TMPA 3B42 and PERSIANN-CDR satellite precipitation products over Malaysia

    Science.gov (United States)

    Tan, Mou Leong; Santo, Harrif

    2018-04-01

    The launch of the Global Precipitation Measurement (GPM) mission has prompted the assessment of the newly released satellite precipitation products (SPPs) in different parts of the world. This study performed an initial comparison of three GPM IMERG products (IMERG_E, IMERG_L and IMERG_F) with its predecessor, the TMPA 3B42 and 3B42RT products, and a long-term PERSIANN-CDR product over Malaysia. The performance of six SPPs was evaluated using 501 precipitation gauges from 12 March 2014 to 29 February 2016. The annual, seasonal, monthly and daily precipitation measurements were validated using three widely used statistical metrics (CC, RMSE and RB). The precipitation detection capability (POD, FAR and CSI), probability density function (PDF) and the 2014-2015 flood event analysis were also considered in this assessment. The results show that all the SPPs perform well in annual and monthly precipitation measurements. The spatial variability of the total annual precipitation in 2015 is well captured by all six SPPs, with high precipitation amount in southern East Malaysia, and low precipitation amount in the middle part of Peninsular Malaysia. In contrast, all the SPPs show moderate correlation at daily precipitation estimations, with better performance during the northeast monsoon season. The performance of all the SPPs is better in eastern Peninsular Malaysia, but poorer in northern Peninsular Malaysia. All the SPPs have good precipitation detection ability, except the PERSIANN-CDR. All the SPPs underestimate the light (0-1 mm/day) and violent (> 50 mm/day) precipitation classes, but overestimate moderate and heavy (1-50 mm/day) precipitation classes. The IMERG is shown to have a better capability in detecting light precipitation (0-1 mm/day) compared to the other SPPs. The PERSIANN-CDR has the worst performance in capturing all the precipitation classes, with significant underestimation of light precipitation (0-1 mm/day) class and overestimation of moderate and

  18. The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2.

    Science.gov (United States)

    Reinink, Peter; Van Rhijn, Ildiko

    2009-07-01

    Alphabeta T cells and gammadelta T cells perform nonoverlapping immune functions. In mammalian species with a high percentage of very diverse gammadelta T cells, like ruminants and pigs, it is often assumed that alphabeta T cells are less diverse than gammadelta T cells. Based on the bovine genome, we have created a map of the bovine TRA/TRD locus and show that, in cattle, in addition to the anticipated >100 TRDV genes, there are also >300 TRAV or TRAV/DV genes. Among the V genes in the TRA/TRD locus, there are several genes that lack a CDR2 and are functionally rearranged and transcribed and, in some cases, have an extended CDR1. The number of bovine V genes is a multiple of the number in mice and humans and may encode T cell receptors that use a novel way of interacting with antigen.

  19. A Peer Review of the Strategy for Characterizing Ransuranics and Technetium Contamination in Uranium Hexafluoride Tails Cylinders

    International Nuclear Information System (INIS)

    Sengupta, S.K.; Randich, E.; Avci, H.I.; Steindler, M.J.; Brumburgh, G.P.

    2000-01-01

    This document provides the findings from a peer review of the Oak Ridge National Laboratory (ORNL) Hightower 2000 study, which set forth a strategy for characterization of low levels of radioactive contaminants in depleted uranium hexafluoride (DUF 6 ) cylinders at the Oak Ridge, Paducah, and Portsmouth gaseous diffusion plants. The information from that study will be used in a DOE-issued request for proposal (RFP) for conversion services from the private sector, to assist vendors in reducing costs associated with contingencies relating to handling this DUF 6 with elevated transuranics (TRUs) and technetium (Tc). The Hightower study developed a general strategy for DUF 6 sampling and analysis in accordance with their task but also recommended the following courses of action: (a) Collect and analyze liquid samples from the two identified Paducah Gaseous Diffusion Plant (PGDP) feed cylinders, feed the DUF 6 into the cascades, and conduct an analysis on the resulting heels by washing and analyzing the wash rinsate; (b) Characterize the cylinder coatings to determine the extent and levels of polychlorinated biphenyl (PCB) contamination; and (c) Verify the characterization of the cylinder inventory's compliance with Department of Transportation (DOT) regulations and the American Society of Mechanical Engineers (ASME) pressure vessel code In addition to the above recommendations, the study also concluded that additional characterization is not likely to result in lower bids by prospective vendors, and that direct sampling of many older tails cylinders may be impractical

  20. Updated systematic review and meta-analysis of the performance of risk prediction rules in children and young people with febrile neutropenia.

    Directory of Open Access Journals (Sweden)

    Robert S Phillips

    Full Text Available Febrile neutropenia is a common and potentially life-threatening complication of treatment for childhood cancer, which has increasingly been subject to targeted treatment based on clinical risk stratification. Our previous meta-analysis demonstrated 16 rules had been described and 2 of them subject to validation in more than one study. We aimed to advance our knowledge of evidence on the discriminatory ability and predictive accuracy of such risk stratification clinical decision rules (CDR for children and young people with cancer by updating our systematic review.The review was conducted in accordance with Centre for Reviews and Dissemination methods, searching multiple electronic databases, using two independent reviewers, formal critical appraisal with QUADAS and meta-analysis with random effects models where appropriate. It was registered with PROSPERO: CRD42011001685.We found 9 new publications describing a further 7 new CDR, and validations of 7 rules. Six CDR have now been subject to testing across more than two data sets. Most validations demonstrated the rule to be less efficient than when initially proposed; geographical differences appeared to be one explanation for this.The use of clinical decision rules will require local validation before widespread use. Considerable uncertainty remains over the most effective rule to use in each population, and an ongoing individual-patient-data meta-analysis should develop and test a more reliable CDR to improve stratification and optimise therapy. Despite current challenges, we believe it will be possible to define an internationally effective CDR to harmonise the treatment of children with febrile neutropenia.

  1. SU-E-P-55: The Reaserch of Cervical Cancer Delivered with Constant Dose Rate and Gantry Speed Arc Therapy(CDR-CAS-IMAT) On Conventional Linac

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, R; Bai, W; Chi, Z; Gao, C; Xiaomei, F [The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei (China); Gao, Y [Hebei General Hospital, Shijiazhuang, Hebei (China)

    2015-06-15

    Purpose: Postoperative cervical cancer patients with large target volume and the target shape is concave, treatmented with static intensity-modulated radiotherapy (IMRT) is time consuming. The purpose of this study is to investigate using constant dose rate and gantry speed arc therapy(CDR-CAS-IMAT) on conventional linear accelrator, by comparing with the IMRT technology to evaluate the performance of CDR-CAS-IMAT on postoperative cervical cancer patients. Methods: 18 cervical cancer patients treated with IMRT on Varian 23IX were replanted using CDR-CAS-IMAT. The plans were generated on Oncentra v4.1 planning system, PTV was prescribed to 50.4 Gy in 28 fractions. Plans were evaluated based on the ability to meet the dose volume histogram. The homogeneity index (HI), conformity index (CI) of target volume, the dose of organs at risk, radiation delivery time and monitor units were also compared. SPSS 19.0 software paired T-test analysis was carried out on the two sets of data. Results: Compared with the IMRT plans PTV’s CI (t= 3.85, P =0.001), CTV’s CI, HI, D90, D95, D98, V95, V98, V100 (t=4.21, −3.18, 2.13, 4.65, 7.79, 2.29, 6.00, 2.13, p=0.001, 0.005, 0.049, 0.000, 0.000, 0.035, 0.000, 0.049), and cord D2 and rectum V40 (t=−2.65, −2.47, p= P =0.017, 0.025), and treatment time and MU (t=−36.0, −6.26, P =0.000, 0.000) were better than that of IMRT group. But the IMRT plans in terms of decreasing bladder V50, bowel V30 (t=2.14, 3.00, P =0.048, 0.008) and low dose irradiation volume were superior to that of CDR-CAS-IMAT plans. There were no significant differences in other statistical index. Conclusion: Cervical cancer patients with CDR-CAS-IMAT on Varian Clinical 23IX can get equivalent or superior dose distribution compared with the IMRT technology. IMAT have much less treatment time and MU can reduce the uncertainty factor and patient discomfort in treatment. This work was supported by the Medical Science Foundation of the health department of Hebei

  2. Review

    Indian Academy of Sciences (India)

    Review. J. Astrophys. Astr., Vol. 36, No. 4, December 2015, pp. 433–445. Line Shape Variability in a Sample of AGN with Broad Lines. D. Ilic1,∗, L. ˇC. Popovic1,2 ... ing from. We give here a comparative review of the line shape variability ..... using the mean continuum flux at 5100 Å and the online calculator for luminosity.

  3. Reviews

    Science.gov (United States)

    2004-01-01

    BOOK REVIEWS (99) Complete A-Z Physics Handbook Science Magic in the Kitchen The Science of Cooking Science Experiments You Can Eat WEB WATCH (101) These journal themes are pasta joke Microwave oven Web links CD REVIEW (104) Electricity and Magnetism, KS3 Big Science Comics

  4. Reviews

    OpenAIRE

    Revista alicantina de estudios ingleses

    1996-01-01

    Contiene: Jan Pilditch, ed. The Critical Response to Katherine Mansfield. Critical Responses in Arts and Letters. 21. Westport, CT: Greenwood Press, 1996 / reviewed by Ana Belén López Pérez; Edith Wharton. Cartas a Morton Fullerton (1907-1931), (Barcelona, Grijalbo Mondadori, 1995). Ed. Marina Premoli. Translation: Esther Gómez / reviewed by Teresa Gómez Reus; Elizabeth Deeds Ermarth. The English Novel in History: 1840-1895. London and New York: Routledge, 1997 / reviewed by Ángel Pé...

  5. INCIDENCE.CDR NEW 1.CDR

    African Journals Online (AJOL)

    and Asia . In most high-income countries, cars make up the largest proportion of the road traffic, while in low- income and middle-income countries pedestrians and riders of bicycles, motorcycles and mopeds are more common. These differences in road users have an important impact on the occurrence of injuries among ...

  6. Review

    Indian Academy of Sciences (India)

    2017-04-18

    jbiosci. J. Biosci. 42(2), June 2017, 345–353 * Indian Academy of Sciences. 345. DOI: 10.1007/s12038-017-9681-x. Keywords. Angiogenesis; FRG1; FSHD; neuromuscular disorder; RNA biogenesis. Review. Published online: ...

  7. Reviews.

    Science.gov (United States)

    Radcliffe, George; And Others

    1988-01-01

    Reviews three software packages: 1) a package containing 68 programs covering general topics in chemistry; 2) a package dealing with acid-base titration curves and allows for variables to be changed; 3) a chemistry tutorial and drill package. (MVL)

  8. Reviews.

    Science.gov (United States)

    Greenleaf, Floyd; And Others

    1986-01-01

    Reviews eight textbooks, readers, and books. Topics include Latin America, colonial America, the Carolinians, women in French textbooks, the Vikings, the Soviet Union, nineteenth-century Black America, and Ernest Rutherford. (TRS)

  9. Review

    African Journals Online (AJOL)

    , complications are relatively common and this needs to be considered in patient counseling and clinical decision making. Review: Fertility generally returns after renal transplantation. Approximately 74% of pregnancies in kidney transplant ...

  10. Reviews

    OpenAIRE

    Revista alicantina de estudios ingleses

    2000-01-01

    Contiene: Villalba, Estefanía. Claves para interpretar la literatura inglesa. Madrid: Alianza Editorial, 1999,211 p. / reviewed by Eva M. Pérez Rodríguez; Dieter Stein & Rosanna Sornicola (ed.) The Virtues of Language. History in Language, Linguistics and Texts. Number 87. Amsterdam: John Benjamin Pub. Co., 1998 / reviewed by José Manuel Belda Medina; Antonia Sánchez-Macarro and R. Carter (eds.) (1998): Linguistic Choice across Genres: Variation in Spoken and Written English. Amsterd...

  11. Assessing the state of the art in biomedical relation extraction: overview of the BioCreative V chemical-disease relation (CDR) task.

    Science.gov (United States)

    Wei, Chih-Hsuan; Peng, Yifan; Leaman, Robert; Davis, Allan Peter; Mattingly, Carolyn J; Li, Jiao; Wiegers, Thomas C; Lu, Zhiyong

    2016-01-01

    Manually curating chemicals, diseases and their relationships is significantly important to biomedical research, but it is plagued by its high cost and the rapid growth of the biomedical literature. In recent years, there has been a growing interest in developing computational approaches for automatic chemical-disease relation (CDR) extraction. Despite these attempts, the lack of a comprehensive benchmarking dataset has limited the comparison of different techniques in order to assess and advance the current state-of-the-art. To this end, we organized a challenge task through BioCreative V to automatically extract CDRs from the literature. We designed two challenge tasks: disease named entity recognition (DNER) and chemical-induced disease (CID) relation extraction. To assist system development and assessment, we created a large annotated text corpus that consisted of human annotations of chemicals, diseases and their interactions from 1500 PubMed articles. 34 teams worldwide participated in the CDR task: 16 (DNER) and 18 (CID). The best systems achieved an F-score of 86.46% for the DNER task--a result that approaches the human inter-annotator agreement (0.8875)--and an F-score of 57.03% for the CID task, the highest results ever reported for such tasks. When combining team results via machine learning, the ensemble system was able to further improve over the best team results by achieving 88.89% and 62.80% in F-score for the DNER and CID task, respectively. Additionally, another novel aspect of our evaluation is to test each participating system's ability to return real-time results: the average response time for each team's DNER and CID web service systems were 5.6 and 9.3 s, respectively. Most teams used hybrid systems for their submissions based on machining learning. Given the level of participation and results, we found our task to be successful in engaging the text-mining research community, producing a large annotated corpus and improving the results of

  12. The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface

    DEFF Research Database (Denmark)

    Rybtke, Morten; Berthelsen, Jens; Yang, Liang

    2015-01-01

    formation and biofilm dispersal. The P. aeruginosa LapG protein is shown to be a functional homolog of the Pseudomonas putida LapG protein which has previously been shown to function as a periplasmic protease that targets the surface adhesin LapA. Transposon mutagenesis and characterization of defined......Pseudomonas aeruginosa is a clinically relevant species involved in biofilm-based chronic infections. We provide evidence that the P. aeruginosa LapG protein functions as a periplasmic protease that can cleave the protein adhesin CdrA off the cell surface, and thereby plays a role in biofilm...

  13. Review

    NARCIS (Netherlands)

    Prud’homme van Reine, W.F.

    1998-01-01

    The two published parts of the Desmid Flora of Austria are well-illustrated review volumes on a group of precious freshwater microalgae. Volume 1 contains a pretty, visual key to the genera, completed by figures of one or more characteristic species. In all keys of the separate genera many visual

  14. Review

    NARCIS (Netherlands)

    Kalkman, C.

    1996-01-01

    The first volume of this series was published in 1991, and reviewed in Blumea 38, p. 216. The treatments of volumes 2 and 3 are each based on a doctor’s thesis by the first author, elaborated under supervision of Dr. Panigrahi. Volume 2 contains regional revisions of six genera: Prunus, Prinsepia,

  15. Review

    DEFF Research Database (Denmark)

    Van Den Hazel, H B; Kielland-Brandt, Morten; Winther, Jakob R.

    1996-01-01

    The yeast vacuole, which is equivalent to the lysosome of higher eukaryotes, is one of the best characterized degradative organelles. This review describes the biosynthesis and function of yeast vacuolar proteases. Most of these enzymes are delivered to the vacuole via the early compartments...

  16. Reviews

    NARCIS (Netherlands)

    Adema, Frits

    1995-01-01

    This is the second volume of a revision of Tabernaemontana (Apocynaceae). The volume covers the New World species (44) and the genus Stemmadenia (10 species). This part of the revision of Tabernaemontana comes up to the high standards set in the first volume [see the review by Leenhouts, Blumea 38

  17. Review

    African Journals Online (AJOL)

    2016-03-19

    Dave Richards and Brian Finch. March 19, 2016, Penguin Random House South Africa, ISBN 978-1775842514, pp. 64, full colour. Price US$10.00/GB£6.70. In this review, I shall attempt to convince readers that ... head and slams her book down as the memory arrives. “Oh no. That bird still sends shivers through me!

  18. Review

    NARCIS (Netherlands)

    Kalkman, C.; Adema, F.

    1998-01-01

    This book intends (according to the preface) to afford at once a review, a general outline of what has been accomplished, and a set of signposts for the future. It attempts to do so in three sections on Origin and Diversification of Primitive Land Plants (4 papers), Origin and Diversification of

  19. Review

    NARCIS (Netherlands)

    Wilde, de W.J.J.O.

    1994-01-01

    This review marks the appearance of Volume II, after the publication of Volume I, Pteridophytes and Gymnosperms, in 1990; several more volumes are expected in the future before completion of the Vascular plants as a whole. The present volume contains 73 families out of some 250-500 families which

  20. Analysis of hydrological changes and flood increase in Niamey based on the PERSIANN-CDR satellite rainfall estimate and hydrological simulations over the 1983–2013 period

    Directory of Open Access Journals (Sweden)

    C. Casse

    2015-06-01

    Full Text Available A dramatic increase in the frequency and intensity of floods due to the Niger River in the city of Niamey (Niger has been observed in the last decade. Previous studies highlighted the role of the land use changes on the flood increase since 1970s. In the last decade, observations have raised the issue of a possible increase in extreme rainfall in the Sahel, which may have caused the recent and extreme floods in Niamey in 2010, 2012 and 2013. The study focuses on the 125 000 km2 basin between Ansongo and Niamey. This is the drainage area of the monsoon rainfall that leads to the rapid flow rise occurring between June and October. To understand the possible role of rainfall in flood intensification, satellite rainfall estimate is attractive in a region where the operational gauge network is sparse. This paper analyses the evolution of the Niger hydrograph in Niamey based on discharge observations, hydrological modelling and the satellite product PERSIANN-CDR, over the 1983–2013 period. PERSIANN-CDR is first compared with four other rainfall products. The salient features of the observed changes, i.e. a marked change in the mean decadal hydrograph, is well mimicked by the simulations, implying that rainfall is the first driver to the observed changes. The increase of flooded years over the period is also well reproduced but with some uncertainties in the exact number of flood days per year.

  1. Preliminary report: NIF laser bundle review

    International Nuclear Information System (INIS)

    Tietbohl, G.L.; Larson, D.W.; Erlandson, A.C.

    1995-01-01

    As requested in the guidance memo 1 , this committe determined whether there are compelling reasons to recommend a change from the NIF CDR baseline laser. The baseline bundle design based on a tradeoff between cost and technical risk, which is replicated four times to create the required 192 beams. The baseline amplifier design uses bottom loading 1x4 slab and flashlamp cassettes for amplifier maintenance and large vacuum enclosures (2.5m high x 7m wide in cross-section for each of the two spatial filters in each of the four bundles. The laser beams are arranged in two laser bays configured in a u-shape around the target area. The entire bundle review effort was performed in a very short time (six weeks) and with limited resources (15 personnel part-time). This should be compared to the effort that produced the CDR design (12 months, 50 to 100 personnel). This committee considered three alternate bundle configurations (2x2, 4x2, and 4x4 bundles), and evaluated each bundle against the baseline design using the seven requested issues in the guidance memo: Cost; schedule; performance risk; maintainability/operability; hardware failure cost exposure; activation; and design flexibility. The issues were reviewed to identify differences between each alternate bundle configuration and the baseline

  2. Melt onset dates for Arctic regions derived from satellite passive microwave data for 1979-2010; a comparison between the operational CDR and research level ESDR data sets

    Science.gov (United States)

    Anderson, M. R.; Bliss, A. C.

    2012-12-01

    The rapid nature and extent of the sea ice loss during recent summers have shown the importance of monitoring melt during the spring and summer transition. Using remotely sensed brightness temperatures, snow overlying sea ice can be identified. The purpose of this presentation is to show the usefulness of the new NOAA CDR for melt onset dates and the new NASA MEaSURES ESDR for melt onset dates records. The NOAA CDR melt onset algorithm is designed as an operational algorithm and uses the daily brightness temperature differences between the 37H and 19H Ghz channels from the special sensor microwave imager (SSMI) and special sensor microwave imager and sounder (SSMIS) on board the Defense Meteorology Satellite Program (DMSP) platform for the years 1987-2007 to determine the melt onset date. The melt onset dates are archived as part of the NOAA CDR for sea ice. The NASA MEaSURES ESDR melt onset date algorithm uses the same brightness temperature differences between the 37H and 19H Ghz channels, however, a ten day window and different thresholds are used to determine melt onset dates. The ESDR melt onset dates are also calculated for the scanning multi-channel microwave sensor (SMMR) on board the NASA Nimbus-7 platform. Therefore ESDR melt onset dates are calculated from 1979-2010. Comparisons are made between the NOAA CDR melt onset date data and the NASA MEaSURES ESDR melt onset date data. For the most part, the two data sets are comparable, indicating melt occurring at roughly the same time during spring. However, there are instances when the two algorithms differ, producing different melt onset dates. The main difference occurs during the earlier part of spring when spurious brightness temperatures are observed. For example, there may be low level clouds containing liquid water passing over the area, affecting the brightness temperature data for a single day, however, there is no change in the snow crystals which the algorithm should identify as melt. To account

  3. Sequence similarities of protein kinase substrates and inhibitors with immunoglobulins and model immunoglobulin homologue: cell adhesion molecule from the living fossil sponge Geodia cydonium. Mapping of coherent database similarities and implications for evolution of CDR1 and hypermutation

    Czech Academy of Sciences Publication Activity Database

    Kubrycht, J.; Borecký, Jiří; Souček, P.; Ježek, Petr

    2004-01-01

    Roč. 49, č. 3 (2004), s. 219-246 ISSN 0015-5632 R&D Projects: GA MZd NJ6747 Institutional research plan: CEZ:AV0Z5011922 Keywords : CDR1 * immunoglobulin Subject RIV: EE - Microbiology, Virology Impact factor: 1.034, year: 2004

  4. Review

    DEFF Research Database (Denmark)

    Van Den Hazel, H B; Kielland-Brandt, Morten; Winther, Jakob R.

    1996-01-01

    The yeast vacuole, which is equivalent to the lysosome of higher eukaryotes, is one of the best characterized degradative organelles. This review describes the biosynthesis and function of yeast vacuolar proteases. Most of these enzymes are delivered to the vacuole via the early compartments...... of the secretory pathway and the endosome, while one of them is directly imported from the cytoplasm. The proteases are synthesized as precursors which undergo many post-translational modifications before the final active form is generated. Proteolytic activation by developments in the analysis of the functions...

  5. Characterization of the CDR3 structure of the Vβ21 T cell clone in patients with P210(BCR-ABL)-positive chronic myeloid leukemia and B-cell acute lymphoblastic leukemia.

    Science.gov (United States)

    Zha, Xianfeng; Chen, Shaohua; Yang, Lijian; Li, Bo; Chen, Yu; Yan, Xiaojuan; Li, Yangqiu

    2011-10-01

    The clonally expanded T cells identified in most cancer patients that respond to tumor-associated antigen such as P210(BCR-ABL) protein have definite, specific antitumor cytotoxicity. T cell receptor (TCR) Vβ CDR3 repertoire diversity was analyzed in patients with chronic myeloid leukemia (CML) and BCR-ABL(+) B-cell acute lymphoblastic leukemia (B-ALL) by GeneScan. A high frequency of oligoclonal expansion of the TCR Vβ21 subfamily was observed in the peripheral blood of CML and B-ALL patients. These clonally expanded Vβ21 T cells were correlated with the pathophysiologic process of CML. A conserved amino acid motif (SLxxV) was observed within the CDR3 region in only 3 patients with CML. Preferential usage of the Jβ segments was also observed in a minority of patients. The 3-dimensional structures of the CDR3 region containing the same motif or using the same Jβ segment displayed low similarity; on the contrary, the conformation of the CDR3 region containing no conserved motif in some T cell clones was highly similar. In conclusion, our findings indicate a high frequency of TCR Vβ21 subfamily expansion in p210(BCR-ABL)-positive CML and B-ALL patients. The characterization of the CDR3 structure was complex. Regrettably, at this time it was not possible to confirm that the Vβ21 T cell clones were derived from the stimulation of p210(BCR-ABL) protein. Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

  6. Failure to Obtain Computed Tomography Imaging in Head Trauma: A Review of Relevant Case Law.

    Science.gov (United States)

    Lindor, Rachel A; Boie, Eric T; Campbell, Ronna L; Hess, Erik P; Sadosty, Annie T

    2015-12-01

    The objectives were to describe lawsuits against providers for failing to order head computed tomography (CT) in cases of head trauma and to determine the potential effects of available clinical decision rules (CDRs) on each lawsuit. The authors collected jury verdicts, settlements, and court opinions regarding alleged malpractice for failure to order head CT in the setting of head trauma from 1972 through February 2014 from an online legal research tool (WestlawNext). Data were abstracted onto a standardized data form. The performance of five CDRs was evaluated. Sixty relevant cases were identified (52 adult, eight children). Of 48 cases with known outcomes, providers were found negligent in 10 cases (six adult, four pediatric), settled in 11 cases (nine adult, two pediatric), and were found not liable in 27 cases. In all 10 cases in which providers were found negligent, every applicable CDR studied would have indicated the need for head CT. In all eight cases involving children, the applicable CDR would have suggested the need for head CT or observation. A review of legal cases reported in a major online legal research system revealed 60 lawsuits in which providers were sued for failing to order head CTs in cases of head trauma. In all cases in which providers were found negligent, CT imaging or observation would have been indicated by every applicable CDR. © 2015 by the Society for Academic Emergency Medicine.

  7. Reviews

    Science.gov (United States)

    2005-07-01

    WE RECOMMEND When Physics Became King This book delves into the history of science since the 18th century. The History of the Laser An interesting read that will teach you far more than its title suggests. History of Physics Selected Reprints A fascinating collection of physics papers spanning four decades. Datalogging set-ups Five great products from Leybold Didactic’s CASSY range. Videocom Measure motion and convert it to graphs with this great device. Basic Raybox This simple piece of equipment offers great performance. WORTH A LOOK Virtual Physics Lab John Nunn’s software demystifies science using clear illustrations. HANDLE WITH CARE Microchem Electricity Kit This box of equipment for introducing electricity lacks quality. Raymond the Raybox A disappointing raybox. The basic version reviewed on p389 is better. WEB WATCH A rough guide to e-learning.

  8. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Fig 1: Phylogenetic tree based on amino acid sequences of haemagglutinin (A) and neuraminidase (B) genes of selected pandemic influenza A/H1N1 strains from Africa. 1257. ISSN 0331-3026. Meseko et al ...

  9. Valid Journal.cdr

    African Journals Online (AJOL)

    dialectical and at the same time eclectic. The regenerative essence of culture deifies and housed .... within the dialectic of new historicism is but a reconstruction of an existing culture. To answer the question of what ..... Same method was adopted for the choice of costumes and props. Dense myths inherent in our history and ...

  10. Oyesiku (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    The mechanism of water condition in the Musci considered in relation to habitat. III. Mosses growing in dry environments. Annals of Botany 47: 889-912. Clausen, E. 1952.Hepatics and humidity. Dansk. Botany Arkive15 (1): 80. Dilks, T.J.K. &Proctor, M.C.F. 1979. Photosynthesis, respiration and water content in bryophytes.

  11. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    To determine the pattern of clinical presentation of carcinoma of the cervix in Nnewi Southeast. Nigeria with a view to ... presented with the advanced form of the disease with 20 (46.5%) and 14 (32.6%) presenting in stage III and IV respectively. ... from lack of established and effective screening protocol, most of the ...

  12. Journal 02.cdr

    African Journals Online (AJOL)

    Stephen

    Deficiency of calcium causes blossom end rot and can be treated by adding lime to the soil or spraying the leaves with a calcium solution. Maintaining adequate .... NPK (15:15:15) fertilizer was applied by spot placement at the rate of 5 g/stand two weeks after transplanting. Manual weeding and staking were done as at ...

  13. march issue.cdr

    African Journals Online (AJOL)

    User

    To determine the incidence and risk of hospital-related TB amongst the health care workers and trainee students of this institution. ... varied from half a year to 11.5 years and the rate of diagnosis of cases varied from nil to 3 per year. Identified risks for .... related TB; it ranged from the security officer at the hospital gate to the ...

  14. Ogolo (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    ABSTRACT. 191. INTRODUCTION. Evapotranspiration (ET) is an essential component of water balance and hydrological cycles. It is a key variable in yield models, water balance, drought prediction, irrigation scheduling and soil traffic ability estimates (karim, 1991; Tyagi et al., 2003; Sabziparvar et al., 2009, 2011). It is also.

  15. Valid Journal.cdr

    African Journals Online (AJOL)

    Nation”. Today, this motto reads thus “Radio Nigeria;. Uplifting the people and uniting the Nation” On February th. 28 1978, a decree was promulgated establishing the Federal. Radio Corporation of Nigeria. (FRCN). In 1992, the. Government established the National Broadcasting. Commission (NBC) a body whose sole aim ...

  16. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    thick, 1 µm sections were cut, stained with toluidine blue and viewed under the light microscope (Olympus. BH2) for tissue ... diamond or glass knife on the ultramicrotome. (Vienna, Austria) .... musculature lead to grinding, pressing and rubbing ...

  17. Fadiya SL (13).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    sidewall of a well by a wireline tool or gun after the well has been drilled. Percussion sidewall cores are obtained by firing a hollow core recovery bullet into the sidewall ...... African Earth Sciences, pp. 283-286. Bankole, S. I.; Schrak, E.; Erdtmann, B. D. and akande, S. O. 2005. Palynostratigraphic and paleoenvironments of ...

  18. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    ABSTRACT. Objective: To determine the association between maternal gingivitis and pregnancy outcome, including low birth weight (LBW) and preterm delivery. This prospective study was conducted among 300 randomly selected pregnant women aged 20-34 years attending the antenatal clinic, University of Benin.

  19. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    extremities in domestic poultry was a serious problem in the ... brought in to the Poultry Clinic of the Veterinary. Teaching Hospital ... disease. The affected quails that were unable to move eventually died, probably due to inability to access feed and water as described by. McNamee and Smyth (2000). Fig 1:Photograph of a ...

  20. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    We report the case of a 16 year old boy who presented with 8 months history of weight loss, 3 months history of polydypsia, polyuria and polyphagia. The child had poor growth since age of 5 years, during which time he developed recurrent abdominal pain for 4 years. A diagnosis of chronic calcific pancreatitis complicated ...

  1. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    relationship between body mass index and relative plasma viscosity in normal young Nigerian adults. A total of 22 normal undergraduate students (8 male and 14 females) of both sexes and between the ages of 18 and 27 years participated in the study. The age, weight and height of each subject was obtained and BMI was.

  2. New draft.cdr

    African Journals Online (AJOL)

    HP USER

    morphology. Pictures of the cysts were captured using digital Camera (Sony, Carl Zeisis, Optical Zoom 4X, 7.2 megapixels), modified and resized using computer program Microsoft office (2007 version). Results. Post mortem inspection of 261 sheep carcasses at. Sokoto abattoir revealed Cysticercus tenuicollis cysts in.

  3. Bamgbose (2).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    biodegradability, safety and cost (Li et al. 1997). A wide range of hydrophilic polymers have been examined for preparing hydrogels and chitosan is one of them. Chitosan is biodegradable and biocompatible. It exhibits bio-adhesive .... solutions were cast into films in plastic petri dishes and air dried for 24 h. The dry films ...

  4. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Twenty non-pregnant, non-lactating female albino wistar rats weighing between. 156.4±12.8 grams wereused in this study. They were assigned to four groups ..... (2007).Melatonin and estradiol effects on food intake, body weight, and leptin in ovariectomized rats.Maturitas.58: 91–101. UDEGBUNAM R.I., AGU, N.N., and.

  5. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Nigerian Veterinary Journal. A R T I C L E. Vol 36 (3) 1222-1225. ABSTRACT. There is paucity of information on the incidence and haematological changes associated with trypanosome infection in Nigerian fishes. This investigation examined randomly buffy coat and blood smears of Tilapia in the wild by direct microscopy ...

  6. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    hypercalcaemia, hyperlipoproteinamia type- I, IV, V, cystic fibrosis, viral infections like mumps and hepatitis, ascaris infestation, as well as biliary and pancreatic duct anomalies. Studies have shown that there is some evidence of permanent pancreatic damage after recovery from malnutrition. Fibrosis follows atrophy of the.

  7. MATERNAL BELIEFS.CDR

    African Journals Online (AJOL)

    Maternal beliefs about infant teething. 1. 2. 3. OG Uti , KO Savage ... Nigeria. 3Department of Community Health, College of Medicine, University of Lagos, Lagos. Nigeria. KEY WORDS: Infant teething. Maternal beliefs. Lagos. Nigeria now accurately .... the questions into the appropriate language or Pidgin. English. Analysis.

  8. Valid Journal.cdr

    African Journals Online (AJOL)

    Hospital in the outskirt of Port Harcourt, Banji Falegan, a lawyer, Papa the Old educationist, Tekena Dokubo, a. Professor of medicine, Chinwe Ejindu with a first class honours degree in mathematics, and of course, the young. Onyema. The playwright has in the play tried to make the electorate choose their leader through ...

  9. Valid Journal.cdr

    African Journals Online (AJOL)

    pre-colonial and Islamic era” (Omojola 16). For better understanding of dance development in Africa as stated .... quasi-informal national cultural policy. Some independent African nations gave dance no ... School Umunze and began to teach them the rudiments of traditional Igbo dance. The exercise was aborted when Mr.

  10. Journal 02.cdr

    African Journals Online (AJOL)

    Stephen

    unintended force molting, egg disposal at unit prices below break-even points, reduction of flock size through sale of live animals, dumping of stale and poorly stored eggs etc. these effects can be further compounded by lack of storage facilities and erratic power outages. The summation of these effects will further precipitate ...

  11. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    Sixty-nine cases of neonatal bacterial meningitis were encountered, (25 were early-onset, and 44 late- onset); the incidence was 6.5/1000 live births. 22 Positive CSF cultures were grown in early-onset meningitis, and 28 in late-onset disease. Low birth weight showed higher risk of bacterial meningitis and it was.

  12. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    cholesterol (LDLc) ≥ 150mg/dL. (3.89mmol/dL). Hypertension was present if systolic blood pressure ≥ 140mmHg or diastolic blood pressure ≥ 90mmHg, or if subject was on antihypertensive medication. Abdominal obesity was defined as WC. >88cm in women and WC > 102 cm in men while generalized obesity was BMI.

  13. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    90mmHg6. All the information which included ethnicity, age, marital status, occupation, highest level of education attained, number of drugs taken, number of drugs prescribed, reason for dosage omissions or discontinuation of drugs were obtained ...

  14. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    history of throat pain, hoarseness of the voice and cough, unconscious or sedated patients, patients too ..... acupuncture point. Anaesthesia 2004; 59: 647-. 651. 10. Post-thyroidectomy sorethroat following endotracheal intubation. ANZ J. Surg. 2001;. 71:669-671. 11. Tracheal intubation and sorethroat: a mechanical ...

  15. Odukoya Abiodun (12).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Keywords: Soil, Dumpsites, Trace Elements, Contamination, Lagos. ABSTRACT. 351. INTRODUCTION. Soil is not only a medium for plants growth or waste disposal but also a transmitter of many pollutants to surface water, ground water, atmosphere and food. Soil pollution may threaten human health not only through its ...

  16. Omafuvbe (18).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Food Technical Biotechnol. 41 (3), 243-246. Rohde, B. and Hartman, G. 1980. Introducing. Mycology by Example. Schering Akti- engesellschaft, Hamburg, 111pp. Santos M., Jimenez, J.J., Bartolome, B., Gomez-. Cordoves, C., Del Nozal ,M.J. 2003. Variability of brewers' spent grain within a brewery. Food Chem. 80, 17-21.

  17. Ukpebor (15).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    conditions were chosen that provided the optimum analyte resolution on a C reverse-phase LC column, along. 18 with optimum ... water and methanol with the addition of 0.1% formic acid (to aid protonation) provided the optimum resolution and ionization of .... to a mass spectrometer (Model LDP00360) was used for this ...

  18. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Poyser NJ, Kelleher MC, Briggs PFA. Managing discolored non vital teeth. The inside/ outside bleaching technique. Dental Update 2004; 31: 204-210. 3. Osuji OO. Traumatized primary teeth in. Nigerian children attending University. Hospital: the delay in seeking treatment. Int. Dent J 1996; 46:165-170. 4. Attin T, Paque´ F, ...

  19. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    with 180µl of the Lysis buffer (ATL) containing 200ng/m lysostaphin; 20mM. Tris Hel; pH 8:0; 2Mm EDTA; 1.2% Triton o and incubated at 37 C for 30mins before proteinase K treatment. The mixture was o then vortexed and incubated at 56 C for 3 hours, with occasional vortexing in between. The tube was briefly centrifuged.

  20. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    environmental sanitation, poor health hygiene, overpopulation and poverty constitute major risk factors to ill-health. Whereas, all these risk factors have been ... lymphadenitis in their study. Yet again, studies by Gupta in India also show that granulomatous lymphadenopathy was the. 2 most common lesions encountered.

  1. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    Aim: To determine the factors affecting the choice of surgery as a future career specialty among medical interns in a regional hospital in ... personal interest and career ambitions . In our setting however, the views of fresh medical ... using Graph pad instat software (2012). P value less than 0.05 was considered significant.

  2. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    acute problems. Furthermore, all children with CVA were newly diagnosed HbSS. It is concluded that sickle cell anaemia related morbidities contribute significantly to paediatric ... Sickle cell disease is a problem of major public health significance as it is a major ... birthday from malaria, bacterial infections. 3,5 and anaemia.

  3. Akinsanya (9).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    The parasitic helminth fauna of a fish Synodontis filamentosus and Calamoichthys calabaricus was investigated. A total of 100 ..... paper, 31: 220pp. Patrlcio, T., and Eileen, R., Walter, G., and Aldo, M. 1991. Gastrointestinal Helminths of Fish. Eating Birds from Chiloe Island,. Chile.Journal of Wildlife Diseases 27(1):178-. 179.

  4. march issue.cdr

    African Journals Online (AJOL)

    User

    suspicion and to thoroughly evaluate cases of stroke in individuals below age 45, especially in the absence of cardiovascular risk factors such as diabetes mellitus, hypertension or hyperlipidemia. 9,10. 5,6,9. 16,17,18. 17,18. 18. 18. 19. REFERENCE. 1. Kappelle IJ, Adas HP Jr, Heffner ML,. Torner JC, Gomez F, Biller J. 2.

  5. Enarvube & Atedhor (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    2Department of Geography and Regional Planning, University of Benin, Benin City, Nigeria .... Aniocha South. The population of the area, according to the 2006 national population census data, is approximately 241,289. Figure 1 shows the location of the study area which lies in ..... Hunter of New South Wales, Australia.

  6. Valid Journal.cdr

    African Journals Online (AJOL)

    The 'she' in the last line refers to Ogwoma. In spite of her futile search for the charm which she claims Ogwoma has used in killing her son and her inability to establish that she has a hand in her son's death the mother-in-law still goes ahead to kill her. 52. 51. Articulation Of Women And Gender Issues In Drama And Theatre .

  7. Valid Journal.cdr

    African Journals Online (AJOL)

    tradition, rites and other practices) which form the bed rock upon which these ideologies are hinged to ... She eats with her left hand from a broken plate or calabash that will never be washed throughout the ... and canker worm eaten deep into the fabrics of our society. The barbaric and inhuman treatment meted on widows ...

  8. 11 Mapping.cdr

    African Journals Online (AJOL)

    Administrator

    KRFR) in the Kadjebi District of the. Volta Region was transformed into digital spatial data, using Landsat ETM+ December 2000 satellite imagery. With available ground data sets, the December 2000 pictorial result of processed Landsat ETM+ ...

  9. march issue.cdr

    African Journals Online (AJOL)

    User

    operated upon in March and October 2005 in order to evaluate the safety of thyroidectomy under local anaesthesia in a rural medical outreach setting in. North central Nigeria. 2, 3. 4. Nigerian Journal of Clinical Practice. March 2008 Vol.11(1) :37-40. THYROIDECTOMY UNDER LOCAL ANAESTHESIA: HOW SAFE?

  10. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    incomplete understanding of factors aiding wound healing, high anaesthetic and surgical complication rates ... Considered obligatory for wound healing, post operative bed rest up to 21 days was commonly enforced on .... but may be problematic in children. Central. (spinal/epidural) anaesthesia and regional blocks.

  11. march issue.cdr

    African Journals Online (AJOL)

    User

    which poses a diagnostic challenge due to limited facilities for thorough investigation. This article, hope to highlight intracardiac lesion (most likely left atria myxoma) as a possible risk factor for stroke in young patients in our environment. Since high index of suspicion is the key to the diagnosis, attending clinicians therefore.

  12. Ukpebor (15).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Liquid chromatography-mass spectrometric conditions were chosen that provided the optimum analyte resolution ..... 1). This was done by isolating the parent ion and subsequently applying a voltage to induce fragmentation into .... Extoxnet. 1996. "EXTOXNET Extension. Toxicology Network Pesticide. Information Profiles.

  13. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

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    . (Glucophage), Imipramine, Paracetamol,. Promethazine, Quinine tablets. Storage of poisons. Kerosene and alcohol were stored in empty bottles of assorted drinks comprising coca cola, fanta, beer, water and empty cups and jerry cans.

  14. Valid Journal.cdr

    African Journals Online (AJOL)

    Chief tells his son, Makwo, to warn his mother who has suddenly turned evil to change her ways. He notes that but for his spiritual sense, she would have killed him long ago. Six months later, Chief introduces Ijeoma to his family saying. “this is my new wife,” and that she will take over from their mother. A woman who has ...

  15. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    brownish discharge from the umbilicus which occurred about 12 days of commencing menstrual period. This was stained her clothes and occurred regularly each month. She had been placed on. Primolut-N (Norethisterone, a progestogen) tablets. 10 mg twice a day for endometriosis of the umbilicus. She was asked to take ...

  16. 05 Pavel 03.cdr

    African Journals Online (AJOL)

    User

    (Skorupa 2004: 120–1). Het boek van een andere Duitse auteur, August Wildenstein, werd in 1900 vertaald door. Władysław Umiński (1865–1954) als Bohater spod Spionkopu (“De held van Spionkop”). In 1901 gaf Umiński hetzelfde boek onder zijn eigen naam uit. Eginhard van Barfus' Im. Lande der Buren (Barfus 1899b) ...

  17. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    odontogenesis cannot be witnessed, fusion and gemination seem to be equivalent, hence the term double tooth/conjoined teeth is used. Double tooth is seen more in the primary dentition than permanent dentition and this has effect on the succedenous dentition such as delayed exfoliation of the affected teeth due to ...

  18. JMBR APRIL.cdr

    African Journals Online (AJOL)

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    Premarital screening for the diagnosis of Sickle Cell Disease is helpful in the prevention of the condition. It provides information about ... and in-utero therapy using stem cell. 2 transplantation. However, prevention of the disease ... estimated that each year over 300,000 babies are born worldwide manifesting severe forms of ...

  19. march issue.cdr

    African Journals Online (AJOL)

    User

    Ectopic breast tissues are subject to the similar physiological and pathological alterations seen in breast tissues situated in their ... Fibroadenoma is the most common benign tumour of the female breast and consist of both epithelial and stromal components. Extra-mammary fibroadenoma, however, is rare. It has been seen ...

  20. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    autopsy the cause of death can be wrong in as many as 30% of cases, although autopsies do not always provide the cause. 4 of death. Nigeria being the most populous country in the region has a very high childhood mortality rate of 157 deaths per 1,000 live. 5 births. Very few epidemiological studies of childhood coroner's ...

  1. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    Children were most often injured as pedestrians while adults and older patients were more often victims of passenger ... severity of head injury and higher frequency of multi-system trauma may contribute to worse outcome in older patients. Head Injury, Pattern, Outcome, Age ..... Risk factors predicting operable intracranial.

  2. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Breast Cancer, war, Female, Undergraduate, Students,. 1. Sambo M.N, Idris S.H, Dahiru I.L , Gobir A.A. Department of Community Medicine, Ahmadu Bello University, Zaria .... Nigeria, South Asia and Brazil. . Knowledge and Practice of Self-breast Examination Among Female Undergraduate Students in a Northern Nigeria ...

  3. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

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    (PSA) and its role in cancer screening. Method of Scoring: Respondents who have heard of prostate cancer ... (52.2%) knew it plays a role in male reproduction while 150 (37.3%) were aware that the prostate gland ... remarkable improvement in the level of awareness and knowledge of prostate cancer after a 1 hour health ...

  4. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Reducing waiting time for PMTCT counselling is crucial to improving client satisfaction. KEYWORD: and Testing, Nigeria ... the workload of counsellors and the waiting time for HIV test results.8 In line with the above, a study was ..... Development Project, 2010:1-2. 15. Cochran WG. Sampling Techniques, 3rd edition, New ...

  5. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

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    having chronic kidney disease, diabetes and hypertension, but clinically stable were recruited from ... in hypertensive and diabetic patients but was normal in CKD (Chronic kidney disease) patients. Blood pressure was increased in CKD patients. Biochemical ..... Diabetes in African American Women, South. Carolina.

  6. march issue.cdr

    African Journals Online (AJOL)

    User

    Departments of *Dental Surgery, **Maxillofacial Surgeon, ***Paediatric ****. Paediatric, Radiology. *Federal Medical Center, Nguru, ... Department of Dental Surgery, Federal Medical. Centre, Nguru, Nigeria, with a history of ... syngnathia co-existent with agenesis or hypoplasia of the proximal mandible. In 2001, Laster et al.

  7. Fadiya & Ojoawo (21).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    invaluable information for consideration in the construction and building purposes of which aim the hole was drilled. ... solving geological problems associated with .... The residue was then transferred carefully into an aluminium plate and dried in an oven at a temperature of o about 60 C for about thirty minutes. The dried.

  8. Valid Journal.cdr

    African Journals Online (AJOL)

    Abstract. This work chronicles some aspects of Yoruba language and culture that are near extinction. We look at the decadent use of. Yoruba by young native speakers. The near loss of some cultural aspects like oríkì (lineage praises), Ekún ìyàwó (nuptial art), ìjálá. (hunters' chant), ìrèmòjé (hunters, dirge), among others, is.

  9. 6 Assessment.cdr

    African Journals Online (AJOL)

    user

    concentrations of both bicarbonate and sulfate ions in solution. This is ... enrichment of the groundwater with sulfate, bicarbonate, and calcium ions. ...... Ghana is likely to pose sodium or salinity effects. This is however dependent on the conditions of the soils, whereby poor drainage can lead to the retention of salts in.

  10. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    and compared with values at initiation of study. There was significant reduction in blood pressure (BP) from .... was done for serial values of the respective parameters monitored over the years. P value < 0.05 was ..... Praga M, Morales E. Renal damage associated with proteinuria. Kidney Int. 2002;62: supl. 82:42-46. 32.

  11. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Alterations in the Hippocampus and Cerebellum of Rats. Nigerian Veterinary Journal. A R T I C L E. Vol 36 (3) 1240-1250. SUMMARY. Cancer causes great morbidity and mortality. Radiotherapy, one of the treatment modalities is associated with neurotoxicity; and oxidative damage has been reported to play an important.

  12. Imande (7).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    We assume that the errors m are distributed with. 1ij zero mean and constant variance and that they are not correlated either with one another across pupils or with the true values x . We make similar. 1ij assumptions about the errors m and q . Now,. 2ij ij where as the adjustment for incidence of errors in. Y were based on an ...

  13. march issue.cdr

    African Journals Online (AJOL)

    User

    certificate of fitness to surgery. Fifteen (9.4%) had lost relations they participated in. RESULT. Requests by family members. Frequency of requests. Payment for services. Refusal to treat/Uncomfortable request. Outcome of treatment. 42. Nigerian Journal of Clinical Practice March. 2008, Vol.11(1). Treatment of Relatives By ...

  14. map jalahalli.cdr

    Indian Academy of Sciences (India)

    RAJAJINAGAR. TUMKUR ROAD. GORAGUNTE PALYA. PLATINUM CITY. YESVANTPUR. M. E. S. R. O. A. D. ACADEMY. FELLOWS. RESIDENCY. ISRO. APTS. I T Qtrs. CFWRI. Play. Ground. R. IN. G. R. O. A. D. HMT SCHOOL. TUMKUR ROAD. CWB .7 km. 0. YESVANTPUR RAIL WAY STATION.

  15. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Department of Veterinary Anatomy University of Agriculture Makurdi, Nigeria, Department of Veterinary Anatomy. University of ..... the roots of the teeth. Nerve block techniques failure occurs if any of these nerves or their branches passes through these accessory foramina (Olopade and Okandeji, 2010). This knowledge is ...

  16. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    Neonatal bacterial meningitis was confirmed if the cerebrospinal fluid (CSF) microbiological, chemical, immunological and ... usefulness of blood cultures in the detection of neonatal bacterial meningitis, increasing resistance of Gram- positive neonatal ...... Nursing Personnel of the Special Care Baby Unit for their good care ...

  17. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    malnutrition and secondary bacterial infections. World Health ... A total number of 43 children with measles presenting at the National Hospital Abuja, seen over a 40 ..... immune response of Nigerian children Arch Dis. Child 1973; 48: 753-6. World Health Organization. Strategies for reducing global measles mortality Wkly.

  18. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    known. Among the pathogenetic mechanisms of the neurological defects of CML suggested in literature so far, hyperleucocytosis-induced stasis. (hyperviscosity syndrome) appears to be the most predominant .This is said to slow down the circulation through small blood vessels in the brainstem and results in deafness .

  19. HEALTH STATUS.CDR

    African Journals Online (AJOL)

    Aaby P, Bukh J, Lisse IM and Smits AJ. Overcrowding and intensive exposure as determinants of measles mortality. Am J Epidemiology 1984;120: 49-63. 19. Aaby P, Samb B, Simondon F, Coll seck AM,. Knudsen K and Whittle H. Non-specific beneficial effect of measles immunisation: analysis of mortality studies from.

  20. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    Method. An open- ended questionnaire on the reasons underlying failure to seek early dental treatment among patients attending a Nigerian tertiary hospital was administered to subjects attending the. Dental and Maxillofacial clinic of the. University of Calabar Teaching Hospital. (UCTH) from November 2010 to April 2011.

  1. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    order to meet these social challenges and needs, it must be research based. This is because within the nursing profession, it is expected that new information in the form of research findings will be incorporated constantly and knowledgeably into nursing practice. This becomes more important as the nurse is a critical link in.

  2. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    This trend is also in keeping with similar works in the local environment; at Abia State University Teaching. Hospital, Aba, CVS cases accounted for 26.1% of the total medical admissions ; while the Nnamdi. Azikiwe University Teaching Hospital study revealed CVS cases (both hypertension and congestive cardiac failure) as ...

  3. Valid Journal.cdr

    African Journals Online (AJOL)

    members cannot use a language proficiently with the majority members. 5. Negative attitude towards language can prove detrimental to the maintenance of that language, while learner with positive attitude towards their own language maintain additive bilingualism. 6. Yoruba language is potentially technically endangered.

  4. Samuel & Odunigba (25).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    container (no cover) and this was labelled C. These three storage containers containing sample feed were stored in a cool dry place of the research laboratory of the Department of. Botany, University of Lagos for six weeks. Table 1: Fish Feed Constituents. Medium Preparation. Twenty grammmes of commercially produced.

  5. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    Males, 5th and 6th decades of life, poor education, lower socioeconomic class,. Margi, Hausa and .... their education. Stratifying the subjects into low and high socioeconomic class, 90.2 % of the users of smokeless tobacco belonged to low socioeconomic class, while 9.8% ... cigarette smoking in Nigeria, Kuwait and India.

  6. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    of the Guthri Smith apparatus frame to which a firm stretcher and two spring balances were attached on a horizontal level position. The heights of the subjects were also taken on supine lying on a firm plinth. The body weight and height of each of the subjects were also measured in standing with the conventional weighing ...

  7. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    Informed consent in surgical practice sometimes involved a process of sharing decisional authority with the patient when the choice hinged on personal values or preferences. This process, in which a continuous physician-patient decision making partnership agrees on an option of treatment, has been described as the best ...

  8. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    ABSTRACT. Close-to-client operation of Patent Medicine Vendors can play a significant role in the fight against malaria if their health knowledge of the disease and appropriate interventions are improved upon. The objective of this study was to assess the effect of health workshop on knowledge of malaria, anti-.

  9. New draft.cdr

    African Journals Online (AJOL)

    HP USER

    agriculture and rural cooperative (CTA). Manual of tropical veterinary parasitology, Pp 113 – 117. Dada BJO & Belino ED (1979). Prevalence of hydatidosis and cysticercosis in slaughtered livestock in. Sokoto state, Nigeria. International Journal of. Zoonoses, 6: 115-117. Dada BJO, Adegboye DS & Mohammed AN (1979).

  10. Akinnifesi (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Numerical simulations of the effect of the presence of point defects in the matrix of ZnO were carried out using MATLAB computation procedure. The variation of impurity atom concentration with the energy gap was simulated. The plot obtained exhibited an exponential increase in energy gap with respect to the concentration.

  11. JMBR vol 7.cdr

    African Journals Online (AJOL)

    Tope

    Bikers. ABSTRACT. The ambient noise level and noise-induced hearing impairment (NIHI) in 200 motorbike riders from six motorbike ... The mean ambient noise for motor bike riders was 90 +10 dB a level significantly. (x=0.000), higher than the .... the metabolic stress exerts pressure on the maximally stimulated cells which ...

  12. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    an impaired immune system leading to high susceptibility to many other viral and bacterial infections (5). Those immunological abnormalities affect both acquired and innate immunity. The impaired immune response may be the possible explanation for the differences between the consequences of HBV exposure of an ...

  13. Valid Journal.cdr

    African Journals Online (AJOL)

    drama as trivial; believe it as reality; and see it as too critical or threatening while capitalists see it as the poor people's advocate. Though make-believe, drama is sort of a ... manipulate the medium as a change agent. Hence, the dramatic medium is an effective channel to canvass for peaceful co-existence and meaningful ...

  14. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    later deformity, and to encourage healing and normal use of the bone3. The operative protocol for the treatment of maxillofacial fractures include one or a combination .... have informed this, it brings to mind the loss in terms of human and material resources that accompanies maxillofacial trauma. The fact that motor vehicle.

  15. Fabiyi (19).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    COASTAL AREAS AND THE EFFECTS ON RURAL COMMUNITIES IN NIGERIA. Fabiyi Oluseyi O. .... environment. Though there is no consensus on the boundaries and geographies of ecosystems, however the importance of ecosystem to human ... sea level rise and coastal submergence on Nigerian coastal area include ...

  16. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Clostridium sp (2.42%), Serratia sp (2.42%). Bacterial isolates from the waste workers were essentially similar to those isolated from the dumpsites although the latter were more heavily colonized. The highest bacterial burden was recorded from the top soil samples at Benin Bye-pass dumpsite with a mean viable count of.

  17. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    anti-inflammatory drugs. Pregnant patients with this disease usually do not have problems. Bleeding time is prolonged in persons with von Willebrand disease, and because the Von Willebrand protein is phase-reactant (i.e., increased synthesis in the presence of inflammation, infection, tissue injury and pregnancy), a mild.

  18. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    ABSTRACT. There is paucity of information on the incidence and haematological changes associated with trypanosome infection in Nigerian fishes. This investigation examined randomly buffy coat and blood smears of Tilapia in the wild by direct microscopy for Trypanosomes and complete haematology were analyzed.

  19. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    babies delivered at SPCH were weighed naked, within the first 30 minutes after birth, by a trained midwife using a mechanical Waymaster weighing .... Teenage twin mothers demonstrated an increased risk of delivery of LBW infants. A similar finding has been reported from Ilorin. Teenage twin mothers may not have the ...

  20. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    periodontitis on pregnancy out-come such as preterm delivery and low birth weight; no published work yet in Nigeria. Also, most studies are on the effect of maternal periodontitis and not gingivitis and plaque-induced gingivitis which is the most common form of periodontal disease in pregnant women. This study may be an.

  1. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    INTRODUCTION/REVIEWOFLITERATURE. Crohn's disease (CD) is a multifactorial polygenic disease characterised by chronic inflammation of the gastrointestinal tract (GIT) . It may involve any part of the GIT. The transmural inflammation characteristic of Crohn's disease predisposes patients to the formation of fistulas and ...

  2. The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening: a systematic review.

    Science.gov (United States)

    Henriksen, Emilie L; Carlsen, Jonathan F; Vejborg, Ilse Mm; Nielsen, Michael B; Lauridsen, Carsten A

    2018-01-01

    Background Early detection of breast cancer (BC) is crucial in lowering the mortality. Purpose To present an overview of studies concerning computer-aided detection (CAD) in screening mammography for early detection of BC and compare diagnostic accuracy and recall rates (RR) of single reading (SR) with SR + CAD and double reading (DR) with SR + CAD. Material and Methods PRISMA guidelines were used as a review protocol. Articles on clinical trials concerning CAD for detection of BC in a screening population were included. The literature search resulted in 1522 records. A total of 1491 records were excluded by abstract and 18 were excluded by full text reading. A total of 13 articles were included. Results All but two studies from the SR vs. SR + CAD group showed an increased sensitivity and/or cancer detection rate (CDR) when adding CAD. The DR vs. SR + CAD group showed no significant differences in sensitivity and CDR. Adding CAD to SR increased the RR and decreased the specificity in all but one study. For the DR vs. SR + CAD group only one study reported a significant difference in RR. Conclusion All but two studies showed an increase in RR, sensitivity and CDR when adding CAD to SR. Compared to DR no statistically significant differences in sensitivity or CDR were reported. Additional studies based on organized population-based screening programs, with longer follow-up time, high-volume readers, and digital mammography are needed to evaluate the efficacy of CAD.

  3. A Systematic Review of the Literature on Women’s Health, 2000-2010

    Science.gov (United States)

    2015-03-30

    Experts for the Military Women’s Health Literature Review (2000-2010) LTC (Ret) Janice Griffin Agazio, PhD, CRNP, RN LCDR Elizabeth Gloor, FNP Maj Aimee L...Braun, APRN, FNP -BC, PhD (c), MBA, JD, FAANP COL Christina C. Hill, MD, FACOG CAPT (Ret) Min Chung-Park, PhD Marjan Holloway, PhD Nakia S. Clemmons, MPH...Everett F. (Pat) Magann, MD, FACOG, FRANZCOG Diane Seibert, PhD, CRNP, FAANP CDR Abigail Marter, PhD (c), MSN, NP-C Maureen Shannon, CNM, FNP , PhD

  4. Antipurinergic therapy for autism-An in-depth review.

    Science.gov (United States)

    Naviaux, Robert K

    2017-12-16

    Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the abnormal persistence of a normal, alternative functional state of mitochondria? A small clinical trial published in 2017 suggests this is possible. Based on a new unifying theory of pathogenesis for autism called the cell danger response (CDR) hypothesis, this study of 10 boys, ages 5-14years, showed that all 5 boys who received antipurinergic therapy (APT) with a single intravenous dose of suramin experienced improvements in all the core symptoms of autism that lasted for 5-8weeks. Language, social interaction, restricted interests, and repetitive movements all improved. Two children who were non-verbal spoke their first sentences. None of these improvements were observed in the placebo group. Larger and longer studies are needed to confirm this promising discovery. This review introduces the concept of M2 (anti-inflammatory) and M1 (pro-inflammatory) mitochondria that are polarized along a functional continuum according to cell stress. The pathophysiology of the CDR, the complementary functions of M1 and M2 mitochondria, relevant gene-environment interactions, and the metabolic underpinnings of behavior are discussed as foundation stones for understanding the improvements in ASD behaviors produced by antipurinergic therapy in this small clinical trial. Copyright © 2017 The Author. Published by Elsevier B.V. All rights reserved.

  5. Department of Energy review of the National Spallation Neutron Source Project

    International Nuclear Information System (INIS)

    1997-06-01

    A Department of Energy (DOE) review of the Conceptual Design Report (CDR) for the National Spallation Neutron Source (NSNS) was conducted. The NSNS will be a new high-power spallation neutron source; initially, it will operate at 1 megawatt (MW), but is designed to be upgradeable to significantly higher power, at lower cost, when accelerator and target technologies are developed for higher power. The 53-member Review Committee examined the projected cost, schedule, technical scope, and management structure described in the CDR. For each of the major components of the NSNS, the Committee determined that the project team had produced credible designs that can be expected to work well. What remains to be done is to integrate the design of these components. With the exception of the liquid mercury target, the NSNS Project will rely heavily on proven technologies and, thus, will face a relatively low risk to successful project completion. The Total Project Cost (TPC) presented to the Committee in the CDR was $1.266 billion in as-spent dollars. In general, the Committee felt that the laboratory consortium had presented a credible estimate for each of the major components but that value engineering might produce some savings. The construction schedule presented to the Committee covered six years beginning in FY 1999. The Committee questioned whether all parts of the project could be completed according to this schedule. In particular, the linac and the conventional facilities appeared to have overly optimistic schedules. The NSNS project team was encouraged to reexamine these activities and to consider a more conservative seven-year schedule. Another concern of the Committee was the management structure. In summary, the Committee felt that this Conceptual Design Report was a very credible proposal, and that there is a high probability for successful completion of this major project within the proposed budget, although the six-year proposed schedule may be optimistic

  6. Department of Energy review of the National Spallation Neutron Source Project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    A Department of Energy (DOE) review of the Conceptual Design Report (CDR) for the National Spallation Neutron Source (NSNS) was conducted. The NSNS will be a new high-power spallation neutron source; initially, it will operate at 1 megawatt (MW), but is designed to be upgradeable to significantly higher power, at lower cost, when accelerator and target technologies are developed for higher power. The 53-member Review Committee examined the projected cost, schedule, technical scope, and management structure described in the CDR. For each of the major components of the NSNS, the Committee determined that the project team had produced credible designs that can be expected to work well. What remains to be done is to integrate the design of these components. With the exception of the liquid mercury target, the NSNS Project will rely heavily on proven technologies and, thus, will face a relatively low risk to successful project completion. The Total Project Cost (TPC) presented to the Committee in the CDR was $1.266 billion in as-spent dollars. In general, the Committee felt that the laboratory consortium had presented a credible estimate for each of the major components but that value engineering might produce some savings. The construction schedule presented to the Committee covered six years beginning in FY 1999. The Committee questioned whether all parts of the project could be completed according to this schedule. In particular, the linac and the conventional facilities appeared to have overly optimistic schedules. The NSNS project team was encouraged to reexamine these activities and to consider a more conservative seven-year schedule. Another concern of the Committee was the management structure. In summary, the Committee felt that this Conceptual Design Report was a very credible proposal, and that there is a high probability for successful completion of this major project within the proposed budget, although the six-year proposed schedule may be optimistic.

  7. Clinical classification in low back pain: best-evidence diagnostic rules based on systematic reviews.

    Science.gov (United States)

    Petersen, Tom; Laslett, Mark; Juhl, Carsten

    2017-05-12

    Clinical examination findings are used in primary care to give an initial diagnosis to patients with low back pain and related leg symptoms. The purpose of this study was to develop best evidence Clinical Diagnostic Rules (CDR] for the identification of the most common patho-anatomical disorders in the lumbar spine; i.e. intervertebral discs, sacroiliac joints, facet joints, bone, muscles, nerve roots, muscles, peripheral nerve tissue, and central nervous system sensitization. A sensitive electronic search strategy using MEDLINE, EMBASE and CINAHL databases was combined with hand searching and citation tracking to identify eligible studies. Criteria for inclusion were: persons with low back pain with or without related leg symptoms, history or physical examination findings suitable for use in primary care, comparison with acceptable reference standards, and statistical reporting permitting calculation of diagnostic value. Quality assessments were made independently by two reviewers using the Quality Assessment of Diagnostic Accuracy Studies tool. Clinical examination findings that were investigated by at least two studies were included and results that met our predefined threshold of positive likelihood ratio ≥ 2 or negative likelihood ratio ≤ 0.5 were considered for the CDR. Sixty-four studies satisfied our eligible criteria. We were able to construct promising CDRs for symptomatic intervertebral disc, sacroiliac joint, spondylolisthesis, disc herniation with nerve root involvement, and spinal stenosis. Single clinical test appear not to be as useful as clusters of tests that are more closely in line with clinical decision making. This is the first comprehensive systematic review of diagnostic accuracy studies that evaluate clinical examination findings for their ability to identify the most common patho-anatomical disorders in the lumbar spine. In some diagnostic categories we have sufficient evidence to recommend a CDR. In others, we have only

  8. Comments on a systematic review and meta-analysis of steroids for epidural injections in spinal stenosis

    Directory of Open Access Journals (Sweden)

    Manchikanti L

    2015-05-01

    Full Text Available Laxmaiah Manchikanti,1,2 Joshua A Hirsch3,41Pain Management Center of Paducah, Paducah, KY, USA; 2Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USA; 3Interventional Care, Minimally Invasive Spine Surgery, Interventional Radiology, NeuroInterventional Services and Neuroendovascular Program, Massachusetts General Hospital, Boston, MA, USA; 4Department of Radiology, Harvard Medical School, Boston, MA, USAWe read with interest the manuscript by Liu et al a systematic review and meta-analysis of steroids for epidural injection in spinal stenosis. The results showed there was fair short- and long-term benefit for treating spinal stenosis with local anesthetic and steroids; however, the authors concluded that the meta-analysis suggested that epidural steroid injections provided limited improvement in short- and long-term benefits in lumbar spinal stenosis patients. This may be confusing to the readership. Fair evidence essentially provides moderate benefits, but the conclusion shows limited improvement.Further, the authors included a wide variety of studies which are not applicable to the meta-analysis. Issues include studies performed with or without fluoroscopy, with short-term and long-term follow-up, with local anesthetic or without local anesthetic, inter-laminar, caudal, and transforaminal approaches, and some very small studies. Multiple studies with variable bias were also included in the meta-analysis. Further, the risk of bias assessment appears to be inappropriate. For example, both studies by Manchikanti et al, even though identical, were rated differently showing variable bias. Further, multiple items were rated inaccurately which differed for each study even though they were identical. These two trials have been assessed in the past in multiple systematic reviews and were rated as high quality, meeting at least 8 of 12 criteria of Cochrane review criteria which have been compressed to 7 in this

  9. Environmental program audit, Paducah Gaseous Diffusion Plant, Paducah, Kentucky. Final report

    International Nuclear Information System (INIS)

    1985-08-01

    The environmental monitoring program, environmental control equipment and its use, and the facility's compliance with DOE orders, Federal and State laws and regulations were evaluated in this audit. No imminent threat to public health and safety was discovered. A needed quality assurance program is being added. Recommendations are given

  10. Final environmental impact assessment of the Paducah Gaseous Diffusion Plant site, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    1982-08-01

    This document considers: the need for uranium enrichment facilities; site location; plant description; and describes the power generating facilities in light of its existing environment. The impacts from continuing operations are compared with alternatives of shutdown, relocation, and alternative power systems. (PSB)

  11. Independent Peer Review of Communications, Navigation, and Networking re-Configurable Testbed (CoNNeCT) Project Antenna Pointing Subsystem (APS) Integrated Gimbal Assembly (IGA) Structural Analysis

    Science.gov (United States)

    Raju, Ivatury S.; Larsen, Curtis E.; Pellicciotti, Joseph W.

    2010-01-01

    Glenn Research Center Chief Engineer's Office requested an independent review of the structural analysis and modeling of the Communications, Navigation, and Networking re-Configurable Testbed (CoNNeCT) Project Antenna Pointing Subsystem (APS) Integrated Gimbal Assembly (IGA) to be conducted by the NASA Engineering and Safety Center (NESC). At this time, the IGA had completed its critical design review (CDR). The assessment was to be a peer review of the NEi-NASTRAN1 model of the APS Antenna, and not a peer review of the design and the analysis that had been completed by the GRC team for CDR. Thus, only a limited amount of information was provided on the structural analysis. However, the NESC team had difficulty separating analysis concerns from modeling issues. The team studied the NASTRAN model, but did not fully investigate how the model was used by the CoNNeCT Project and how the Project was interpreting the results. The team's findings, observations, and NESC recommendations are contained in this report.

  12. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    , pelvic floor repairs. , repair of vesico-vaginal fistulae, bartholin cyst marsupialisation, urethral bouginage, excision of breast lumps, mastectomy, tubal ligation, and. 5-8 thyroidectomies .He is truly the surgeon-in-general. He also doubles as a ...

  13. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    Role of research and innovation. · The future of Rural surgery. Geographical Scope. The scope of Rural ... acquire these skills by taking time off to be exposed to the rural surgery environment as obtains in India. The .... Trained and quality staff are often difficult to hire and retain. Doctors are reluctant to work in rural areas.

  14. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    Objective. Communication between the surgeon and the patient is a core clinical skill. The ability to communicate with patients and their family members is very important in the optimum care of the surgical patient. Few studies have assessed communication between surgical trainees and their patients in sub-Saharan. Africa ...

  15. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    All Correspondence: Dr MON Ibe. Central Medicare. 43 Okigwe Road. Box 453, Owerri,. Imo State, Nigeria. E-mail: Snowwhyte_hosp@yahoo.com. Abstract. Objective and Background: There are various postulated possible ... nerve root injury, vascular injury, development of pseudo-aneurysms and arterio-venous fistulas,.

  16. Asowata et al (10).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    (Nyarko et al., 2006; Ajmone-Marsan et al., 2008). Sediment contamination and subsequent pollution resulting ..... leachate, such as alloys for corrosion resistant equipment and batteries. The third group consists of U .... Abimbola, A.F., Asaah, V.A. and Suh, C.E, 2006. Heavy Metal Concentrations and. Distribution in Surface ...

  17. Okonji et al (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    information on the properties of rhodanese from garden snails. ... column and equilibrated with 0.05 M citrate buffer. (pH 5.0). Three millilitres (3 ml) of enzyme solution from the preceding step was then layered on the column. The column was then washed ... active fractions from the column were pooled and dialyzed against ...

  18. Ajikah et al (11).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Faculty of Science, Senate Building and New Hall respectively. A total of 3,495 palynomorphs belonging to ... dust mites, insect debris and organic dust present in the air (Hyde, 1972). Another point of ..... Table 2: Percentage Composition of Total Pollen Counts from Senate Building. Ajikah et al.: Palynological Survey of ...

  19. Oke et al (3).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    The study revealed that flow in pipe network analysis varied with the method. The flow was a function of the method used, length and diameter of the pipe; and withdraws from the node. The values of model of selection criterion and coefficient of determination varied from 1.2195 to 24.5549 and 0.7912 to 0.9751 respectively.

  20. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Noah Olatoye

    The analyses are based upon the values obtained from the actuarial valuation ... his nal or average salary at retirement, and the length of ..... Actuary. Ibadan: Board Publications Ltd. Pension Reform Act No. 2 (2004). Abuja: Federal Government of Nigeria. Pension Reform Act (2014). Abuja: Federal Government of Nigeria.

  1. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    It is native to West Africa and is cultivated for its use as food, medicinal or ornamental purposes. Eggplant fruits are .... Functional Ecology. 15(5):688-695. Imonide, E.M. and Obi, I.V. (1991) “Rapid Method of Estimating Total Maize Plant Leaf Area as. Affected by Genotype and Fertilizer Rate''.East African Agriculture and ...

  2. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    Variance Parameter. Sigma square δ2. 0.069. 4.9***. Gamma. Γ. 0.71. 7.1***. Logliklehood Ratio. 28.9. Mean technical efficiency. 0.88. Minimum technical ... farmer need to increase output by 53% to reach the frontier while the most efficient fish farmer in the area need to increase his output by only 3%. The mean efficiency.

  3. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    progressive despite no signs of discomfort exhibited by the dog. Medical history revealed current vaccination. Physical examination revealed a non-painful bilateral perineal swelling with partially reducible contents. On digital rectal palpation, there was bilateral absence ofthe pelvic diaphragm, rectal dilatation and.

  4. Oyebola and Awodiran (7).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Clariidae) is very popular in Nigeria due to its adaptable culture characteristic which has endeared it to many fish farmers. Clarias gariepinus is the most popular fish of culture in Nigeria and most fish farmers undertake its production. ..... Fish Centre, Penang, Malaysia, pp 130. Oyebola and Awodiran: Effect of Spawning ...

  5. PDF-JOURNAL 2006.cdr

    African Journals Online (AJOL)

    identified after 24-48 hours using physical examinations (morphological characteristics and colony count with the help of a +20.00D magnifying lens), and biochemical tests (Gram staining and coagulase test) according to Baker et al . The chi-square (X ) test at the 0.05 level of significance was used to test for statistical.

  6. Olorunfemi et al (11).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    There is currently no study on the genotoxicity evaluation of bilge water using molecular maker. Physicochemical analysis of ... powerful molecular marker assay for the detection of the genotoxic effect of bilge water. Keywords: Bilge water, RAPD, ... used, most of which leak into the water through bilge pumping. Depending ...

  7. PDF-JOURNAL 2006.cdr

    African Journals Online (AJOL)

    INTRODUCTION. Man ingests every palatable and edible substance, which he believes can quench his hunger and satisfy his nutritional needs. Some of these edible foods are consumed, not only for their nutritional values, but also for their medical potentials. Some have adverse effect(s) when taken inexcess.

  8. Cover Final May.cdr

    Indian Academy of Sciences (India)

    user

    1926-04-17

    Narasimhan was born on April 17, 1926, in Madras (now Chennai), India. He grew up in. Mylapore, a middle class area of Chennai. The school where he had studied, the P S High. School, was an elite school, but was not known at that time for its teaching of science. Narasimhan joined the College of Engineering in Guindy, ...

  9. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    diagnosed were fibroadenoma, followed by breast cysts. Most breast lesions had been reported to be benign in previous studies. (1,2,3,14,15), this is in tandem with our finding which also reported that fibroadenoma of the breast was more prevalent than other breast lesions, though some studies had postulated other.

  10. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    paramount rather than depending on the traditional model of bring your own infrastructure. Keywords: In ation, Sub-Sahara Africa, Panel .... components like xed effect, trend or a mixture of xed effects and trend; represents the .... Li, Qi, Juan Lin, and Jeffrey S. Racine (2013). Optimal bandwidth selection for nonparametric.

  11. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    ORIGINAL RESEARCH ARTICLES. User and ... Key words: Teenage pregnancy, Cross-sectional Survey, Secondary School, Nigeria, High School Drop-out. Cette enquête sur ... widely used “three delays model”to disentangle different perspectives and to identify a feasible strategy of action to improve access to timely and ...

  12. Cover Final May.cdr

    Indian Academy of Sciences (India)

    user

    interdisciplinary area of psychology, linguistics and computer science. He was curious about how children acquire language abilities. His thesis was opposed to the mainstream thinking which prevailed then and he maintained that the acquisition of. Email:rajaram@serc.iisc.ernet.in. Even though R. Narasimhan is known.

  13. Ajayi and Ogunjobi (10).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Research & Application 8: 181-194. Atwood, T.C.; Weeks, H.P., Jr. 2002. Sex- and age- specific patterns of mineral lick use by white-tailed deer (Odocoileus virginianus). Amer. Midl. Natur. 148: 289-296. Atwood, T.C., Weeks, H. P., Jr. 2003. Sex-specific patterns of mineral lick preference in white-tailed deer. Northeast Nat.

  14. Afolabi et al (17).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Very Low Frequency Electromagnetic (VLF-EM), Electrical Resistivity (ER) hydrogeological, hydrochemical ... earth. All plants and animals must have water to survive. Accessing pure, clean and safe or potable water is of primary concern to individuals, organizations and governments alike. .... total field at each station.

  15. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    sector, information and communication sector, manufacturing sector, transportation and other services. INFLATION. According to National Bureau of Statistics. (NBS), in ation, measured by Consumer Price. Index (CPI) ... Nigeria can produce (rice, starch, sugar, wheat etc.) to promote domestic production and local content ...

  16. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    developments, embryologists have only microscopic observations to assess the quality of embryos. After more ... fiber optic technology, in an office procedure without general anesthesia, as the first arm of the study, and to ... advanced fiber optic microlaparoscopic set in an office procedure. The day of oocyte retrieval was.

  17. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    This paper reports two scenarios whereby goring injury sustained by a Bunaji bull and a Yankasa lamb were managed by pastoralists before the cases were ... The injuries caused by horns of cattle or buffaloes are of various shapes, sizes and ... Physical examination of the bull revealed the following vital parameters; ...

  18. Ayeni and Egharevba (14).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    INTRODUCTION. Studies of Mannich base complexes have grown over the years due to the selectivity and sensitivity of the ligands to various metal ions. Several media have been reported to operate for the reaction including acidic, basic and neutral media (Syamala,. 2009).In practice, phenols can serve as substrate.

  19. Alao and Oludare (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    This study estimated reservoir properties, classified the reservoir sand-facies distribution and identified potential hydrocarbon pay zones. This was with a view to optimizing placements of wells in “Bigola” Field. Conventional interpretation of seismic and well datasets was carried out to provide the sub-surface structures and ...

  20. Falebita et al (4).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    These indicate that they have above minimum TOC to generate hydrocarbon .... exploration. At the deep-water toe of the delta, a series of large fold and thrust belts composed of thrust faults and fault-related folds have been reported (Wu and Bally, 2000; Corredor et al., ..... continental margins: American Geophysical.

  1. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    designed to improve access to social housing, is expected to operate as a PPP to the tune of about N1 trillion. While PPPs explore private capital in the provision of infrastructure and reduces the. nancial burden of the government in delivering such projects, one of the key features of PPPs lies in their ability to relieve the.

  2. Olorunfemi et al (16).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Oshoke, O.J. 2010, Acute toxicity of glyphosate on Clarias gariepinus fingerlings. Journal of Research in Forestry, Wildlife and. Environment 2(2): 150-155. Okayi, R.G., Daku, V. and Mbata, F.U. 2013, Some aquatic macrophytes and water quality parameters of River Guma, Benue,. Nigeria. Nigerian Journal of Fisheries and.

  3. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    EI. Amber1**. 1Department of Veterinary Surgery and Medicine,. 2Department of Veterinary Anatomy,. 3Department of Veterinary Pathology and Microbiology, ... Rabbit kidneys preserved in Euro-Collins alone did not improve preservation time nor protect vascular endothelium, which regulate function and urine excretion in ...

  4. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    Methods:A descriptive study of consenting patients referred for colonoscopy at the endoscopy unit of the. University College ... Objectif: L'intubation caecale est une mesure importante de la qualité de la coloscopie. L'information sur l'effet du temps de la coloscopie sur le taux d'intubation caecale (CIR) est rare. Cette étude ...

  5. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    La maladie rénale chronique constitue un problème de santé publique avec une incidence croissante, une prévalence, de mauvais résultats et un coût élevé. La sensibilisation et le dépistage de l'insuffisance rénale chronique demeurent faibles partout dans le monde. Ainsi, des millions de personnes à travers le monde ...

  6. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    aspergilloma or complications such as bronchiectasis are also known causes of haemoptysis world wide. However, cystic fibrosis (CF) is the commonest etiologic factor in Europe. Haematemesis may be misinterpreted as haemoptysis, particularly when accurate history is not possible in children. Therefore, bleeding from.

  7. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    Production Function for Panel Data'' Journal of Empirical Economics, 20:325-332. Battese, G.E. and G.S. Corra (1977): “Estimation of a Production Frontier Model with. Application to the Pastoral Zone of Eastern Australia” Journal of Agricultural. Economics, 21: 169-179. Battese, G.E. and G.A. Tessema (1993): “Estimation of ...

  8. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    single institution experience. Ann Thorac. Cardiovasc Surg. 2000; 4: 232-5. ACKNOWLEDGEMENT. REFERENCES. 1. Osinusi K. 2. Aderele WI. 3. Hendrickse RG. 4. Wong KS, Wang CR, Lin TY. 5. Coss-Bu JA, Sachdeva RC, Bricker JT,. Harrison GM, Jefferson. LS. 6. Van Kralingen KW, Van Kralin. 7. Patel U, Pattison CW, ...

  9. 09g julycovcurv.cdr

    Indian Academy of Sciences (India)

    mathematics (see the article by Vivek Monteiro in this issue). India has had a long tradition of honoring its teachers – the gurus of our land. Unfortunately, today our teachers, including math- ematics teachers, are not as well treated as they should be in terms of academic respect and financial compensation. Most of.

  10. 1 Ecosystem-based.cdr

    African Journals Online (AJOL)

    Administrator

    methodology that can be adapted to a wide range of situations and particular problems of sustainable ... appropriate adaptation to local, national and regional conditions. It also requested the identification of good ... show how good or bad a particular value is. Compatibility with existing methodologies. (e.g. water quality ...

  11. Shaibu and Watkins (3).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    of them can be prepared. Structurally they are compounds in ... base. Furthermore, enzymes such as tryptophan synthase, transaminases, transketolases, etc. are observed to contain Schiff bases (Wojciechowski et al. 2003). There are two types of ... This paper reports the synthesis of four. Schiff bases derived from the ...

  12. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    Route used. Number %. Oral (concoction). 2. 9.5. Vaginal (suppository). 4. 19.0. Rectal (suppository). 5. 23.8. Rectal (Enema). 7. 33.3. Topical (on th e navel) 3. 14.3. TOTAL. 21. 100. Table 5: Route of Herbal Preparations used for emergency contraception. African Journal of Reproductive Health - June 2011; 15(2): 150 ...

  13. Njan et al (9).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    induced pain through analgesiometer, tail immersion test, hot-plate, and acetic acid-induced analgesic test methods. HME, significantly and dose-dependently produced analgesic effects ... intensive work has been done in this area of ethnopharmacology (Iwalewa et al., 2003,. Omisore et al., 2004, Fadeyi et al., 2004, ...

  14. Ajayi et al (24).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    for 2 hr with intermittent shaking. The absorbance ... Thereafter, they were fasted for 16 hours but allowed access to water ad libitum prior to intraperitoneal administration of alloxan dissolved in 0.9 % saline at 50 mg/kg BW. Hyperglycaemia was confirmed in the alloxan- treated rats by measuring the fasting blood glucose.

  15. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    Parenting Style and Family Functioning. The. ANNALS of the American Academy of Political and Social Science, 2008, 615: 11-37. 16. Peatling S. Children of single parents disadvantaged for longer. Federal Politics, 2013,. 1-4. 17. Yeung JWK & Chan YC. Family functioning of. Chinese families on an impoverished.

  16. Akanni et al (11).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    disturb the structure of the solvent as well as affect the micellar characteristics. The specific volumes ... arguments for the existence of micelles and the model or .... of decanoic acid at three different temperatures. Table 1: Relative Viscosity and Specific Volume of Some Concentrations of Glucose in. Water at 307 K. Percent ...

  17. Edegbai and Emofurieta (12).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Maastrichtian Tidal flat sequences from the northern Anambra. Basin, Southern Nigeria. Nig. Assoc. Petrol. Explor. Bull. 6, p.56-66. Akaegbobi, M. I., Nwachukwu, J. I., and Smith, M. 2000. Aromatic hydrocarbon distribution and calculation of oil and gas volumes in. Post Santonian Shale and Coal, Anambra. Basin, Nigeria.

  18. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    study showed that fruits and vegetable were contaminated with potential food borne pathogens with varying degree ... fruits and vegetables include; Escherichia coli, Salmonella spp., Listeria monocytogenes,. Aeromonas .... Malassieziaand Aspergillus specieshad a close prevalence rates of 24.1% and 21.4% respectively.

  19. Chemical Data Reporting rule (CDR)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains information on chemicals that company's produce domestically or import into the United States during the principal reporting year. For the 2012...

  20. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    of steroidal oral contraceptive methods. In a community such as ours with these confirmed prevalent risk factors predisposing to cervical cancer, it is considered important to determine the antenatal women's knowledge of cervical cancer, screening with papinicolaous smear test as well the utilization of the Pap smear test.

  1. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Correspondence: Tel.: +2347031092062, E-mail: torkarshima@yahoo.co.uk. Abstract. This study was carried out to determine the prevalence of biting flies from Gashaka, Ibi and Karim Lamido Local. Government Areas (LGA) of Taraba State between July and ...

  2. 09g julycovcurv.cdr

    Indian Academy of Sciences (India)

    638. Snippets of Physics. Random Walk Through Random Walks – I. T Padmanabhan. 650. Aerobasics – An Introduction to Aeronautics. Airplane Propulsion. S P Govinda Raju. GENERAL ARTICLES. 667. Model Checking. Automated Verification of Computational Systems. Madhavan Mukund. 682. Computational Lower ...

  3. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    This might be partly explained by the fact that percentage of morphologically normal spermatozoa increases as the male ages and reach highest at puberty as reported by Rekwot (1987) which is true for this study where all rams used had attained puberty. The findings in this study were consistent with those of Barth et al.

  4. Adekunle et al (8).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Ife Journal of Science vol. 17, no. 3 (2015) ... Aspergillus niger had the highest ability to degrade diesel and spent engine oil with efficiency of 84% and 95% in ..... research. REFERENCES. Adekunle, A. A. and Adebambo, O. A. 2007. Petroleum Hydrocarbon Utilization by. Fungi Isolated From Detarium senegalense. Seeds.

  5. PDF-JOURNAL 2006.cdr

    African Journals Online (AJOL)

    AGING CHANGES IN VISION. DEVELOPMENT. Ageing is a life long process of progressive physiological changes in biological, psychological and social structure of a person, which no ... lesions affecting the brain and visual pathway and a decrease in the number of cortical cells. There are three possible refractive states.

  6. Abdul et al (9).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Some stock parameters of Elops lacerta in Ogun State coastal estuary, Nigeria were carried out between February and July, 2014. Data were collected on ... 2012 (FDF, 2013). Despite the significance of this fishery in Nigeria, there is dearth of ..... years and growth performance index, ɸ , was. 3.036/year. Estimates of growth ...

  7. Oresajo et al (15).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    fluvial depositional settings to pro delta and deltaic shorelines. The Agbada Formation is generally interpreted to contain fluvial deltaic deposits. (Weber and Daukoru, 1975). The maximum flooding surfaces (MFS) delineated in the study area are interpreted to have developed during the highest point of sea level rise and.

  8. Okiongbo and Soronnadi (22).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Pleistocene eustatic sea levels. The Coastal Plain. Sands (Benin Formation) fluvial in origin have been identified as the main regional and most important freshwater water bearing aquifer in the study area. Groundwater in the Coastal Plain. Sands occurs mainly under phreatic (unconfined) conditions. The sediments of the ...

  9. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    spacing between births if the mother has not yet given birth to a male child is lower when compared to the need for a female child; among the Yoruba the preceding birth interval is shorter if the unmet sex preference is female than when it is male. A tentative inference from these findings is that of son preference among the ...

  10. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Abstract. The meat retail selling points are the major places where people usually purchase meat from morning through to evening at retail points in Samaru, Zaria. A total of 100 meat samples were collected from five different retail meat selling points in Samaru market Zaria, Kaduna state. Twenty samples were obtained ...

  11. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    water for irrigation is very poor due to the high level of heavy metals in water and sediment. Consequently, the ... plethora of human activities, Of all the human activities, industrial waste is the most common source of water pollution in .... input which got distributed into the water body and sediment during the course of their.

  12. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    Saharan Africa . Things started to deteriorate from mid-1990s. By late 1990s, a political and economic crisis unfolded in. Zimbabwe. As a result the country witnessed a two- digit negative growth rates, a sky-rocketing inflation, a decline in the rule of ...

  13. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    before analysis with pH meter. Diagnosis and management. Hydrated lime toxicity was diagnosed. In managing the case, the surviving juveniles (Plate 1) were transferred to a fresh pond, and prophylactically treated with broad spectrum antibiotic (oxytetetracycline/neomycin) and vitamin supplement incorporated in feed at ...

  14. Asaolu et al (16).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    and fractions of Citrus sinensis stem-bark, investigate and to evaluate the hepatoprotective potential of the most active fraction (EAF) of the ethanolic ... Ngogang, 2005). Many herbs contain antioxidant compounds which protect the cells ... Eighteen albino mice of either sex, bred from the same colony, weighing between 20 ...

  15. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Noah Olatoye

    contribution and de ned bene t pension plans in three workplace scenarios in Nigeria that differed only on how monthly ... that the cash balance mean gratuity and the cash balance mean pension are individually higher than those of the traditional ..... Pension scheme in Nigeria: History, problems and prospects. Arab.

  16. Oke et al (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    means they are perfectly positively correlated; while its correlation with Krishna Rao Formula is. (+0.999), which means they are highly positively correlated. Oke et al.: Comparative Analysis of Groundwater Recharge Estimation Value. Table 7: Inter-Item Correlation Matrix of Annual Areal Recharge. Modified. Chaturvedi ...

  17. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    134,119,91,65,51. 6. -Terpenene. HM. 1062. 9.6. 136,121,105,91,65. 7. Terpinolene. HM. 1001. 3.3. 136,115,93,67,53. 8. Linalool. OM. 1098. 4.6. 154,121,93,71,53. 9. Sabinene. Hydrate. OM. 1068. 5. 154,121,93,71,55. 10. Camphor. OM. 1143. 1.6. 152,108,95,77,55. 11. Terpinen-4-ol. OM. 1177. 29.8. 154,111,93, 71,53.

  18. Jacob et al (21).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    1Department of Chemistry, Federal University of Technology, Minna, Nigeria. 2Department of Chemistry, University of Abuja, PMB 117, Abuja, Nigeria ... pesticides, use of polluted water for irrigation, waste disposal, industrial and mining activities. (Ashish et al., 2013). Massive and regular chemical analysis of farmland soil ...

  19. Oyebola et al (23).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    3+ described elsewhere (Oyebola et al., 2010). Ho absorption peaks were obtained from transmission studies carried out with a Cary 5000. UV-VIS-NIR spectrophotometer and corresponding absorption coefficients deduced using the Beer-Lambert law. Spectral emission measurements were carried out using the schematic ...

  20. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    , Ahmadu Bello University, Zaria. 2Veterinary Teaching Hospital, Ahmadu Bello University, Zaria. *Correspondence: Tel.: +2348062261840, E-mail: connections4life@yahoo.com,. Abstract. This paper reports two scenarios whereby goring ...

  1. Elueze et al (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Appraisal of the functional potential of the marble based on mineralogical, chemical, physical and mechanical characteristics indicate that Obajana marble ... varying stages of geological, engineering and economic appraisals. It is noteworthy ... N-S structural trends of the basement rocks. (Grants, et al.,1972; Turner, 1983).

  2. Adeoye et al (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    showed that all the ASF recovered pigs tested positive, the Large White had more of ASF antibody compared .... haemoglobin and white blood cell differentials ..... Adeloye, A. A., Fatoba T. A and. Soladoye A. O. 2005. Haematological and biochemical parameters of West African. Dwarf goats. Livestock Research for Rural.

  3. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    Unintended pregnancy and termination of studies among students in Anambra state, Nigeria: Are secondary schools playing their part? Abstract. Key words: Teenage pregnancy, Cross-sectional Survey, Secondary School, Nigeria, High School Drop-out. Cette étude a évalué les efforts des écoles secondaires pour prévenir ...

  4. PDF-JOURNAL 2006.cdr

    African Journals Online (AJOL)

    general public while latter acts both as a clinical guide to the practitioner and as an assurance to the patient that the practitioner has ... The external structures are those that can be observed during external examination while the internal structure can be observed with basic instruments and some expertise. The authors ...

  5. Dankwah et al (12).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    breakfast cereals (Tareke et al., 2002). Coultate. (2009), has reported that prolonged heating of legumes .... (2005). A mass of 1.0 g portion of defatted treated. Cajanus cajan sample was measured into a 50 mL ... added and the mixture was vortex briefly to disperse test portion in 30 mL of 70 % acetonitrile. A volume of 500 ...

  6. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    Patients in both groups were supplemented with progesterone (Prontogest 400 mg / day, IBSA Egypt) starting from day 3 following the oocyte retrieval. Pregnancies were diagnosed with Tandom Icon urine hCG test (Hybritech, USA), and upon positive urine tests, serum B-hCG levels were quantifed. The status of pregnancy ...

  7. Okiyi et al (8).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    of the site for civil engineering construction works. Fifty six (56) VES stations were occupied along eight (8) traverses while the dipole-dipole profiling was carried out along segments of three of the traverses. The VES curves were quantitatively interpreted and the results were used for the generation of geoelectric sections ...

  8. Idowu et al (19).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    lakes, rivers and canals) and lateral or vertical inter- aquifer flow (MacDonald et al., 2005). Typically, it travels vertically ... been used for the evaluation of Opeki drainage. Basin, also in southwestern Nigeria, by Idowu and ... Nigeria in which the drainage basins of the study area are located. The daily discharge values were.

  9. Akinlabi et al (10).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    In order to establish empirical equations that relate layer resistivity values with geotechnical parameters for engineering site characterization, geotechnical tests comprising Standard Penetration Test (SPT), Atterberg limit, Triaxial Compression and Oedometer consolidation tests were conducted on soil samples collected ...

  10. Elueze et al (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    characteristics of the marble deposits, in order to lucidly elucidate its functional applications. This is anticipated to complement other efforts towards sustainable development of industrial mineral sector of the country. GEOLOGICAL SETTING. Geology of Lokoja-Jakura Schist Belt. Rocks of Obajana area lie within the Lokoja-.

  11. Oyebola et al (23).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Most laser gain media are characterized by emission quenching in the mid-IR wavelength region as a result of the high phonon structure of such media. The need for more emission in the mid-IR region has made the development of low phonon hosts a major research interest. In this work, we compared the infrared ...

  12. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    modifications dans l'usage des contraceptifs chez les adolescentes sexuellement actives (âgées de 15-19). Les résultats montrent qu'entre 2003 et 2008, il y a eu une augmentation importante dans l'usage actuel de n'importe quelle méthode contraceptive (de 23,7% à 35,1%, p=0,03). Ils indiquent également un ...

  13. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    because of a swollen perineum. Physical and laboratory examinations revealed normal parameters, however a bilateral protrusion was noticed at the perineum suggestive of a bilateral perineal hernia. Contrast radiography revealed a hernia sac with intestinal segments on the left, urinary bladder and prostate on the right.

  14. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    the reproductive age, attending the gynecologic and family planning clinics in Ahmadu Bello University. Teaching Hospital Zaria, Nigeria (ABUTH) during the period of ... dorsal position on an examination couch.An unlubricated bivalve speculum was inserted into the vagina and a cervical cytology specimen was obtained.

  15. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    disapproved Omri (2013) by investigating EKC hypothesis for 36 high income economies. (including Bahrain .... emission in Singapore, Philippines, Malaysia,. Thailand and Indonesia. The relationship between .... Environmental taxes and economic growth: evidence from panel causality tests. Journal of Energy Economics ...

  16. 09g julycovcurv.cdr

    Indian Academy of Sciences (India)

    Reproduced with permission from W W Sawyer, A Path to Modern Mathematics, pp.19-32, 1966. 19. Page 2. 723. RESONANCE │ July 2009. CLASSICS. 20. Page 3. 724. RESONANCE │ July 2009. CLASSICS. 21. Page 4. 725. RESONANCE │ July 2009. CLASSICS. 22. Page 5. 726. RESONANCE │ July 2009.

  17. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    This paper examines the impact of in ation on economic growth in Sub-Saharan Africa in order to provide an empirical evidence whether in ation hinders or ... 2017, as a result of a recovery in oil production in Nigeria, increasing government .... lead to loss of power (Breitung, 2000). Therefore, Im et al. (2003) correct this.

  18. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    , pharmacists, image scientists and nurses to elicit facts and information on issues, challenges and problems they experience in their hospitals. The findings of their experiences revealed that constellation of social, economic and environmental ...

  19. Laniyan et al (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    effect of fuel combustion and quarry activities behind the residential area. The study concluded that the ... the emission of fuel combustion into the atmosphere. ..... Internal journal environment and waste management 8: 40 – 61. Piper, A. M. 1944. A Graphical procedure in Geo –. Chemical interpretation of water analysis.

  20. 10 Watershed Disturbance.cdr

    African Journals Online (AJOL)

    Administrator

    plant species and several endemic butterfly species like N. lamborni and B. ... been colonized by invasive species notably the Siam weed ..... to climate change. If these activities are not checked, the water bodies which owe their existence to the watershed will be negatively affected. Conclusion. The study examined the ...

  1. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    in Morocco. Abstract. Key words: Reproductive health, social determinants, inequity, regional disparities. La population marocaine a connu une croissance ..... the Public Sphere. MENA Development. Report, 2004, Washington , DC. 18. Boutayeb S, Boutayeb A & Bensouda Y. Inequalities and Disparities in North Africa.

  2. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    lateness in the disbursement of farm credit were major problems in credit allocation and utilization. In conclusion, most ... However in Nigeria, findings have revealed that one of the major problems confronting small scale farmers is poor ... According to Okojie et al (2010), the lack of bank accounts, collateral, and information ...

  3. Adewale et al (18).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    period of Pan-African magmatism. Pegmatites are formed from granitic magmas in the final stages of crystallization. These pegmatites, if mineralized contains varying proportions of minerals such as Beryl, Tourmaline, Tantalite and. Columbite. The metals recovered from pegmatite are Niobium, Tin, Thorium and Uranium.

  4. Ezeh et al (17).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    According to the United Nations Environmental. Programme/World Health Organization,. (UNEP/WHO, 1994), atmospheric particulate matter have been implicated to cause adverse effects on human health, visibility and climate, ecosystems and deterioration of physical properties The influence of atmospheric aerosols.

  5. Adewuyi et al (19).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    KBr disc pellets of the biopolymer samples were recorded on a Perkin-Elmer Fourier Transformed. Infra-red (FTIR) spectrophotometer version. 10.03.07, while that of PVAc product was recorded on high resolution SCHIMADZU. FTIR-8400S (Tokyo, Japan). Synthesis of Zn(II)-Chitosan Biopolymeric. Complex. Zn(II)-Chit was ...

  6. 5 Water Quality.cdr

    African Journals Online (AJOL)

    Administrator

    (mg/l CaCO )3. Fe. 0.908 ± 0.679. 20. 1.03 ± 1.76. 26. 0.579 ± 0.614. 13. SD: Standard Deviation; N: number of Samples. Calcium, Magnesium and Chloride had their mean values significantly different from each other in the three river basins. The. P< 0.001, p < 0.003, P< 0.001 were ANOVA significant values for Calcium, ...

  7. Umebese and Fabiyi (4).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    of stomata aperture, decreased photosynthetic activity leading to chlorosis and necrosis of leaves, total decrease in ... of photosynthesis, stomata conductance, and transpiration could also be affected by the application of SA ..... Phytoremediation of. Cr (III) by Ipomonea aquatica (water spinach) from water in the presence of.

  8. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    stock of external reserve sustained a continued marginal increase driven ... Investment (FPI) showed a slight increase.. State of the ... investments. The tight monetary policy environment, according to the CBN, is required to combat rising in ation, ensure exchange rate stability and stimulate economic activities. EXCHANGE ...

  9. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    fashion world and products despite Nigeria's comparative advantage in the industry. Tough investment climate, the high cost of credit and low nished goods standards for exports have also hindered the leather industry in Nigeria. Highly fragmented Cattle rearing market –. Nigeria's cattle rearing industry is dominated.

  10. Adejoro et al (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Quantum mechanics gives a mathematical description of the behavior of electrons that have never been found to be wrong. However, the quantum mechanical equations have never been solved exactly for any chemical system other than the hydrogen atom. Thus, the entire field of computational chemistry is built around.

  11. Fehintola et al (13).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    ADSORPTION EQUILIBRIUM ISOTHERMS OF Pb , Ni AND Cd ONTO. POWDERED EGG SHELLS. 2. 2. 2. 1. Fehintola E. O.; Obijole , O. A.; Amoko , J. S. and Oke , I. A.. 1Department of Civil Engineering, Obafemi Awolowo University, Ile-Ife, Nigeria. E-mail: okeia@oauife.edu.ng;. 2Department of Chemistry, Adeyemi ...

  12. yahaya et al.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Anatomical Study of the Variations of the Facial bones in Skull of the Camel ... osteological investigation or osteoarchaeology, and also offer elements for eventual comparative studies that can be used for tracing origin of the animal. Key words: Morphology ... region of the skull of various domestic animals is composed of os ...

  13. Laniyan et al (16).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    they are hazard-resistant construction materials. (Hodgson et al., 2000) These geo-materials which are also known as geotechnical materials can be found between the ground surface and the rock and influences the structural damage examples of such are marble, clay, soil, activated charcoal/carbon, this materials can ...

  14. Health technology assessment of drugs for rare diseases: insights, trends, and reasons for negative recommendations from the CADTH common drug review.

    Science.gov (United States)

    Janoudi, Ghayath; Amegatse, William; McIntosh, Brendan; Sehgal, Chander; Richter, Trevor

    2016-12-01

    A shift in biochemical research towards drugs for rare diseases has created new challenges for the pharmaceutical industry, government regulators, health technology assessment agencies, and public and private payers. In this article, we aim to comprehensively review, characterize, identify possible trends, and explore reasons for negative reimbursement recommendations in submissions made to the Common Drug Review (CDR) for drugs for rare diseases (DRD) at the Canadian Agency for Drugs and Technologies in Health (CADTH), a publicly funded pan-Canadian health technology assessment agency. A public database (cadth.ca) was screened to identify DRD submissions to CDR. A diseases prevalence of ≤50 per 100,000 people was considered a rare disease. We calculated descriptive statistics for prevalence, study design, study size, treatment cost, reimbursement recommendation types, and reasons for negative reimbursement recommendations. From 2004 to 2015, 63 of 434 submissions to the CDR were for DRD (range: 1 submission in 2005 to 10 submissions in 2013). Most (74.6%) submissions included at least one double-blind randomized controlled trial (RCT). The average study size was 190 patients (range: 20 to 742). The average annual treatment cost was C$215,631 (range: $9,706 to $940,084). Reimbursement recommendations were positive for 54% of the submissions. Negative reimbursement recommendations were made due to a lack of clinical effectiveness (38.5%), insufficient evidence (30.8%), multiple reasons (23.1%), or lack of cost effectiveness/high cost (7.7%). The number of DRD submissions to CDR increased since 2013; from 4 to 5 per year between 2004 and 2012, to 10, 9, and 8 in 2013, 2014, and 2015 respectively. More than half of DRD submissions received positive reimbursement recommendation. Poor quality evidence and/or lack of supportive clinical evidence was at least partly responsible for a negative reimbursement recommendation in all cases. Although the average cost of DRD

  15. Effectiveness of Integration and Re-Integration into Work Strategies for Persons with Chronic Conditions: A Systematic Review of European Strategies

    Directory of Open Access Journals (Sweden)

    Carla Sabariego

    2018-03-01

    Full Text Available Due to low employment rates associated to chronic conditions in Europe, it is essential to foster effective integration and re-integration into work strategies. The objective of this systematic review is to summarize the evidence on the effectiveness of strategies for integration and re-integration to work for persons with chronic diseases or with musculoskeletal disorders, implemented in Europe in the past five years. A systematic search was conducted in MedLine, PsycINFO, CDR-HTA, CDR-DARE and Cochrane Systematic Reviews. Overall, 32 relevant publications were identified. Of these, 21 were considered eligible after a methodological assessment and included. Positive changes in employment status, return to work and sick leave outcomes were achieved with graded sickness-absence certificates, part-time sick leave, early ergonomic interventions for back pain, disability evaluation followed by information and advice, and with multidisciplinary, coordinated and tailored return to work interventions. Additionally, a positive association between the co-existence of active labour market policies to promote employment and passive support measures (e.g., pensions or benefits and the probability of finding a job was observed. Research on the evaluation of the effectiveness of strategies targeting integration and re-integration into work for persons with chronic health conditions needs, however, to be improved and strengthened.

  16. Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients

    Directory of Open Access Journals (Sweden)

    Natali Pier

    2009-03-01

    Full Text Available Abstract Background Assessment of T-cell diversity, besides giving insights about the molecular basis of tumor antigen recognition, has clinical implications since it provides criteria for evaluating antigen-specific T cells clinically relevant for spontaneous and vaccine-induced anti-tumor activity. Melan-A is one of the melanoma antigens most frequently recognized by peripheral and tumor-infiltrating lymphocytes in HLA-A2+ melanoma patients. Many clinical trials involving anti-tumor vaccination have been conducted using modified versions of this peptide. Methods We conducted an in-depth characterization of 210 T-cell receptor beta chain (TRB clonotypes derived from T cells of HLA-A2+ melanoma patients displaying cytotoxic activity against natural and A27L-modified Melan-A peptides. One hundred and thirteen Melan-A-specific clonotypes from melanoma-free subjects, 199 clonotypes from T-cell clones from melanoma patients specific for melanoma antigens other than Melan-A, and 305 clonotypes derived from T cells of HLA-A2+ individuals showing unrelated specificities, were used as control. After sequence analysis, performed according to the IMGT definitions, TRBV and TRBJ usage, CDR3 length and amino acid composition were compared in the four groups of clonotypes. Results TRB sequences of Melan-A-specific clonotypes obtained from melanoma patients were highly heterogeneous, but displayed a preferential usage of few TRBV and TRBJ segments. Furthermore, they included a recurrent "public" amino acid motif (Glycine-Leucine-Glycine at positions 110-112-113 of the CDR3 rearranged with dominant TRBV and TRBJ segments and, in one case, associated with a full conservation of the entire TRB sequence. Conclusion Contrary to what observed for public anti-Melan-A T-cell receptor alpha motifs, which had been identified in several clonotypes of both melanoma patients and healthy controls, the unexpectedly high contribution of a public TRB motif in the recognition

  17. Community Visions for the Paducah Gaseous Diffusion Plant Site

    Energy Technology Data Exchange (ETDEWEB)

    Ormsbee, Lindell e [Civil Engineering, Univ. of KY; Kipp, James A [Univ. of KY, Kentucky water research Institute

    2011-09-01

    This report focuses on assessing community preferences for the future use of the PGDP site, given the site's pending closure by US DOE. The project approach fostered interaction and engagement with the public based on lessons learned at other complex DOE environmental cleanup sites and upon the integration of a number of principles and approaches to public engagement from the Project Team's local, state, regional and international public engagement experience. The results of the study provide the community with a record of the diversity of values and preferences related to the environmental cleanup and future use of the site.

  18. Final report. Paducah Gaseous Diffusion Plant PCB sediment survey: Big Bayou Creek and Little Bayou Creek, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-12-01

    Laboratory analysis of collected samples along drainage features at PGDP. Report documents levels of PCB contamination and considers locations of contamination and known releases to theorize probable sources to further investigate.

  19. Review the 'peer review'.

    Science.gov (United States)

    Blockeel, Christophe; Drakopoulos, Panagiotis; Polyzos, Nikolaos P; Tournaye, Herman; García-Velasco, Juan Antonio

    2017-12-01

    Peer review has been the main form of appraisal of scientific knowledge for over a century. In essence, this process involves the evaluation of a scientific finding by independent experts prior to its dissemination to the scientific community, in an attempt to ensure that both the research and conclusions meet the necessary standards regarding quality, accuracy, relevance and novelty. However, although 'peer review' is considered the current gold standard, it is far from perfect. A focus on the methodology of an article and reviewers' training are key messages for the scientific community. Guidelines on how to review an article are needed and may help reviewers deal with this difficult process. Copyright © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  20. Thor (Total-house waste recycling). A new technology for recovery of urban wastes in refuse derived fuel (RDF); Thor (Total-house waste recycling). Una tecnologia alternativa per la conversione di rifiuti solidi urbani in combustibile da rifiuto (CDR)

    Energy Technology Data Exchange (ETDEWEB)

    Plescia, P.; Mauro, E.; Benedetti, S.; Gizi, D. [Consiglio Nazionale delle Ricerche, Istituto Trattamento Minerali, Monterotondo, Rome (Italy)

    2001-06-01

    to the areas to reclaimed, such as the abusive landfills. [Italian] In questo lavoro viene presentata la nuova tecnologia THOR (Total-House-waste recycling) per il trattamento di rifiuti solidi urbani (RSU) e la loro conversione in combustibili da rifiuto (CDR). La tecnologia THOR si basa sull'utilizzo di un reattore meccanochimico, un mulino ad alta velocita' con elevato rapporto massa macinante/materiale macinato, applicato alla frazione organica umida e secca del rifiuto. Le trasformazioni indotte dal reattore meccanochimico sul rifiuto sono di vario tipo: un'essiccazione quasi completa, una riduzione dimensionale con un prodotto finale con D80 inferiore ai 30 mm e una omogeneizzazione, una eliminazione di alogeni che si combinano in forma salina ed una cessione di ioni metallici. Questi ultimi, in fase di trattamento possono essere legati ad un reattivo ad hoc al fine di rimuoverli definitivamente dal CDR prodotto. A valle del trattamento il prodotto in uscita e' costituito da un materiale secco con un contenuto di carbonio totale minimo superiore al 65% e di idrogeno totale pari al 12%, avente un potere calorifico pari o superiore a 4600 kcal/kg. Il combustibile cosi' prodotto risulta essere privo di alogeni ed ha un tenore in solfo ridotto rispetto ai valori indicati dalla normativa europea. Le ceneri risultanti dalla combustione di qusto prodotto sono povere in metalli, in quanto questi vengono estratti durante la trasformazione dal trattamento meccanochimico. Un'ulteriore elemento positivo di questa tecnologia e' legato all'assenza di emissioni di atmosfera, quali gas-serra, NO{sub x}, polveri e diossine. Le prove effettuate in impianto da laboratorio hanno dimostrato la fattibilita' della tecnologia. L'impianto sperimentale che verra' realizzato con questa tecnologia avra' una produttivita' di 3-5 ton/ora, e sara' adeguato al trattamento dei RSU di comunita' di circa 30