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Sample records for cdr review paducah

  1. Spent nuclear fuel Canister Storage Building CDR Review Committee report

    International Nuclear Information System (INIS)

    Dana, W.P.

    1995-12-01

    The Canister Storage Building (CSB) is a subproject under the Spent Nuclear Fuels Major System Acquisition. This subproject is necessary to design and construct a facility capable of providing dry storage of repackaged spent fuels received from K Basins. The CSB project completed a Conceptual Design Report (CDR) implementing current project requirements. A Design Review Committee was established to review the CDR. This document is the final report summarizing that review

  2. Review of earthquake hazard assessments of plant sites at Paducah, Kentucky and Portsmouth, Ohio

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    Members of the US Geological Survey staff in Golden, Colorado, have reviewed the submissions of Lawrence Livermore National Laboratory (LLNL) staff and of Risk Engineering, Inc. (REI) (Golden, Colorado) for seismic hazard estimates for Department of Energy facilities at Portsmouth, Ohio, and Paducah, Kentucky. We reviewed the historical seismicity and seismotectonics near the two sites, and general features of the LLNL and EPRI/SOG methodologies used by LLNL and Risk Engineering respectively, and also the separate Risk Engineering methodology used at Paducah. We discussed generic issues that affect the modeling of both sites, and performed alternative calculations to determine sensitivities of seismic hazard results to various assumptions and models in an attempt to assign reasonable bounding values of the hazard. In our studies we find that peak acceleration values of 0.08 g for Portsmouth and 0.32 g for Paducah represent central values of the, ground motions obtained at 1000-year return periods. Peak accelerations obtained in the LLNL and Risk Engineering studies have medians near these values (results obtained using the EPRI/SOG methodology appear low at both sites), and we believe that these medians are appropriate values for use in the evaluation of systems, structures, and components for seismic structural integrity and for the seismic design of new and improved systems, structures, and components at Portsmouth and Paducah.

  3. Review of earthquake hazard assessments of plant sites at Paducah, Kentucky, and Portsmouth, Ohio

    International Nuclear Information System (INIS)

    1992-03-01

    Members of the US Geological Survey staff in Golden, Colorado, have reviewed the submissions of Lawrence Livermore National Laboratory (LLNL) staff and of Risk Engineering, Inc. (REI) (Golden, Colorado) for seismic hazard estimates for Department of Energy facilities at Portsmouth, Ohio, and Paducah, Kentucky. We reviewed the historical seismicity and seismotectonics near the two sites, and general features of the LLNL and EPRI/SOG methodologies used by LLNL and Risk Engineering respectively, and also the separate Risk Engineering methodology used at Paducah. We discussed generic issues that affect the modeling of both sites, and performed alternative calculations to determine sensitivities of seismic hazard results to various assumptions and models in an attempt to assign reasonable bounding values of the hazard. In our studies we find that peak acceleration values of 0.08 g for Portsmouth and 0.32 g for Paducah represent central values of the ground motions obtained at 1000-year return periods. Peak accelerations obtained in the LLNL and Risk Engineering studies have medians near these values (results obtained using the EPRI/SOG methodology appear low at both sites), and we believe that these medians are appropriate values for use in the evaluation of systems, structures, and components for seismic structural integrity and for the seismic design of new and improved systems, structures, and components at Portsmouth and Paducah

  4. Review of earthquake hazard assessments of plant sites at Paducah, Kentucky and Portsmouth, Ohio

    International Nuclear Information System (INIS)

    1997-01-01

    Members of the US Geological Survey staff in Golden, Colorado, have reviewed the submissions of Lawrence Livermore National Laboratory (LLNL) staff and of Risk Engineering, Inc. (REI) (Golden, Colorado) for seismic hazard estimates for Department of Energy facilities at Portsmouth, Ohio, and Paducah, Kentucky. We reviewed the historical seismicity and seismotectonics near the two sites, and general features of the LLNL and EPRI/SOG methodologies used by LLNL and Risk Engineering respectively, and also the separate Risk Engineering methodology used at Paducah. We discussed generic issues that affect the modeling of both sites, and performed alternative calculations to determine sensitivities of seismic hazard results to various assumptions and models in an attempt to assign reasonable bounding values of the hazard. In our studies we find that peak acceleration values of 0.08 g for Portsmouth and 0.32 g for Paducah represent central values of the, ground motions obtained at 1000-year return periods. Peak accelerations obtained in the LLNL and Risk Engineering studies have medians near these values (results obtained using the EPRI/SOG methodology appear low at both sites), and we believe that these medians are appropriate values for use in the evaluation of systems, structures, and components for seismic structural integrity and for the seismic design of new and improved systems, structures, and components at Portsmouth and Paducah

  5. Optical System Critical Design Review (CDR) Flight Software Summary

    Science.gov (United States)

    Khorrami, Mori

    2006-01-01

    The Mid Infrared Instrument (MIRI FSW presentation covers: (1) Optical System FSW only and Cooling System FSW is covered at its CDR (2) Requirements & Interfaces (3) Relationship with the ISIM FSW (4) FSW Design Drivers & Solutions.

  6. Independent Technical Review of the C-400 Interim Remedial Project Phase I Results, Paducah, Kentucky

    International Nuclear Information System (INIS)

    Looney, B.; Rossabi, J.; Stewart, L.; Richards, W.

    2010-01-01

    The groundwater and soil in the vicinity of the C-400 Building at the Paducah Gaseous Diffusion Plant (PGDP), is contaminated with substantial quantities of industrial solvents, primarily trichoroethene (TCE). This solvent 'source' is recognized as a significant challenge and an important remediation target in the overall environmental cleanup strategy for PGDP. Thus, the cleanup of the C-400 TCE Source is a principal focus for the Department of Energy (DOE) and its contractors, and for PGDP regulators and stakeholders. Using a formal investigation, feasibility study and decision process, Electrical Resistance Heating (ERH) was selected for the treatment of the soil and groundwater in the vicinity of C-400. ERH was selected as an interim action to remove 'a significant portion of the contaminant mass of TCE at the C-400 Cleaning Building area through treatment' with the longer term goal of reducing 'the period the TCE concentration in groundwater remains above its Maximum Contaminant Level (MCL).' ERH is a thermal treatment that enhances the removal of TCE and related solvents from soil and groundwater. The heterogeneous conditions at PGDP, particularly the high permeability regional gravel aquifer (RGA), are challenging to ERH. Thus, a phased approach is being followed to implement this relatively expensive and complex remediation technology. Conceptually, the phased approach encourages safety and efficiency by providing a 'lessons learned' process and allowing appropriate adjustments to be identified and implemented prior to follow-on phase(s) of treatment. More specifically, early deployment targeted portions of the challenging RGA treatment zone with relatively little contamination reducing the risk of adverse collateral impacts from underperformance in terms of heating and capture. Because of the importance and scope of the C-400 TCE source remediation activities, DOE chartered an Independent Technical Review (ITR) in 2007 to assess the C-400 ERH plans prior

  7. INDEPENDENT TECHNICAL REVIEW OF THE C-400 INTERIM REMEDIAL PROJECT PHASE I RESULTS, PADUCAH, KENTUCKY

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Rossabi, J.; Stewart,L.; Richards, W.

    2010-10-29

    The groundwater and soil in the vicinity of the C-400 Building at the Paducah Gaseous Diffusion Plant (PGDP), is contaminated with substantial quantities of industrial solvents, primarily trichoroethene (TCE). This solvent 'source' is recognized as a significant challenge and an important remediation target in the overall environmental cleanup strategy for PGDP. Thus, the cleanup of the C-400 TCE Source is a principal focus for the Department of Energy (DOE) and its contractors, and for PGDP regulators and stakeholders. Using a formal investigation, feasibility study and decision process, Electrical Resistance Heating (ERH) was selected for the treatment of the soil and groundwater in the vicinity of C-400. ERH was selected as an interim action to remove 'a significant portion of the contaminant mass of TCE at the C-400 Cleaning Building area through treatment' with the longer term goal of reducing 'the period the TCE concentration in groundwater remains above its Maximum Contaminant Level (MCL).' ERH is a thermal treatment that enhances the removal of TCE and related solvents from soil and groundwater. The heterogeneous conditions at PGDP, particularly the high permeability regional gravel aquifer (RGA), are challenging to ERH. Thus, a phased approach is being followed to implement this relatively expensive and complex remediation technology. Conceptually, the phased approach encourages safety and efficiency by providing a 'lessons learned' process and allowing appropriate adjustments to be identified and implemented prior to follow-on phase(s) of treatment. More specifically, early deployment targeted portions of the challenging RGA treatment zone with relatively little contamination reducing the risk of adverse collateral impacts from underperformance in terms of heating and capture. Because of the importance and scope of the C-400 TCE source remediation activities, DOE chartered an Independent Technical Review (ITR) in

  8. 77 FR 51789 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-08-27

    ... management and related activities. Tentative Agenda Call to Order, Introductions, Review of Agenda... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act...

  9. REVIEW REPORT: BUILDING C-400 THERMAL TREATMENT 90 PERCENT REMEDIAL DESIGN REPORT AND SITE INVESTIGATION, PGDP, PADUCAH, KENTUCKY

    International Nuclear Information System (INIS)

    Looney, B; Jed Costanza, J; Eva Davis, E; Joe Rossabi, J; Lloyd Stewart, L; Hans Stroo, H

    2007-01-01

    On 9 April 2007, the U.S. Department of Energy (DOE) Headquarters, Office of Soil and Groundwater Remediation (EM-22) initiated an Independent Technical Review (ITR) of the 90% Remedial Design Report (RDR) and Site Investigation (RDSI) for thermal treatment of trichloroethylene (TCE) in the soil and groundwater in the vicinity of Building C-400 at the Paducah Gaseous Diffusion Plant (PGDP). The general ITR goals were to assess the technical adequacy of the 90% RDSI and provide recommendations sufficient for DOE to determine if modifications are warranted pertaining to the design, schedule, or cost of implementing the proposed design. The ultimate goal of the effort was to assist the DOE Paducah/Portsmouth Project Office (PPPO) and their contractor team in ''removing'' the TCE source zone located near the C-400 Building. This report provides the ITR findings and recommendations and supporting evaluations as needed to facilitate use of the recommendations. The ITR team supports the remedial action objective (RAO) at C-400 to reduce the TCE source area via subsurface Electrical Resistance Heating (ERH). Further, the ITR team commends PPPO, their contractor team, regulators, and stakeholders for the significant efforts taken in preparing the 90% RDR. To maximize TCE removal at the target source area, several themes emerge from the review which the ITR team believes should be considered and addressed before implementing the thermal treatment. These themes include the need for: (1) Accurate and site-specific models as the basis to verify the ERH design for full-scale implementation for this challenging hydrogeologic setting; (2) Flexible project implementation and operation to allow the project team to respond to observations and data collected during construction and operation; (3) Defensible performance metrics and monitoring, appropriate for ERH, to ensure sufficient and efficient clean-up; and (4) Comprehensive (creative and diverse) contingencies to address the

  10. Thermal Analysis of Iodine Satellite (iSAT) from Preliminary Design Review (PDR) to Critical Design Review (CDR)

    Science.gov (United States)

    Mauro, Stephanie

    2016-01-01

    The Iodine Satellite (iSAT) is a 12U cubesat with a primary mission to demonstrate the iodine fueled Hall Effect Thruster (HET) propulsion system. The spacecraft (SC) will operate throughout a one year mission in an effort to mature the propulsion system for use in future applications. The benefit of the HET is that it uses a propellant, iodine, which is easy to store and provides a high thrust-to-mass ratio. This paper will describe the thermal analysis and design of the SC between Preliminary Design Review (PDR) and Critical Design Review (CDR). The design of the satellite has undergone many changes due to a variety of challenges, both before PDR and during the time period discussed in this paper. Thermal challenges associated with the system include a high power density, small amounts of available radiative surface area, localized temperature requirements of the propulsion components, and unknown orbital parameters. The thermal control system is implemented to maintain component temperatures within their respective operational limits throughout the mission, while also maintaining propulsion components at the high temperatures needed to allow gaseous iodine propellant to flow. The design includes heaters, insulation, radiators, coatings, and thermal straps. Currently, the maximum temperatures for several components are near to their maximum operation limit, and the battery is close to its minimum operation limit. Mitigation strategies and planned work to solve these challenges will be discussed.

  11. Independent Technical Review Of The Focused Feasibility Study And Proposed Plan For Designated Solid Waste Management Units Contributing To The Southwest Groundwater Plume At The Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Looney, B.; Eddy-Dilek, C.; Amidon, M.; Rossabi, J.; Stewart, L.

    2011-01-01

    The U. S. Department of Energy (DOE) is currently developing a Proposed Plan (PP) for remediation of designated sources of chlorinated solvents that contribute contamination to the Southwest (SW) Groundwater Plume at the Paducah Gaseous Diffusion Plant (PGDP), in Paducah, KY. The principal contaminants in the SW Plume are trichloroethene (TCE) and other volatile organic compounds (VOCs); these industrial solvents were used and disposed in various facilities and locations at PGDP. In the SW plume area, residual TCE sources are primarily in the fine-grained sediments of the Upper Continental Recharge System (UCRS), a partially saturated zone that delivers contaminants downward into the coarse-grained Regional Gravel Aquifer (RGA). The RGA serves as the significant lateral groundwater transport pathway for the plume. In the SW Plume area, the four main contributing TCE source units are: (1) Solid Waste Management Unit (SWMU) 1 / Oil Landfarm; (2) C-720 Building TCE Northeast Spill Site (SWMU 211A); (3) C-720 Building TCE Southeast Spill Site (SWMU 211B); and (4) C-747 Contaminated Burial Yard (SWMU 4). The PP presents the Preferred Alternatives for remediation of VOCs in the UCRS at the Oil Landfarm and the C-720 Building spill sites. The basis for the PP is documented in a Focused Feasibility Study (FFS) (DOE, 2011) and a Site Investigation Report (SI) (DOE, 2007). The SW plume is currently within the boundaries of PGDP (i.e., does not extend off-site). Nonetheless, reasonable mitigation of the multiple contaminant sources contributing to the SW plume is one of the necessary components identified in the PGDP End State Vision (DOE, 2005). Because of the importance of the proposed actions DOE assembled an Independent Technical Review (ITR) team to provide input and assistance in finalizing the PP.

  12. INDEPENDENT TECHNICAL REVIEW OF THE FOCUSED FEASIBILITY STUDY AND PROPOSED PLAN FOR DESIGNATED SOLID WASTE MANAGEMENT UNITS CONTRIBUTING TO THE SOUTHWEST GROUNDWATER PLUME AT THE PADUCAH GASEOUS DIFFUSION PLANT

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Eddy-Dilek, C.; Amidon, M.; Rossabi, J.; Stewart, L.

    2011-05-31

    The U. S. Department of Energy (DOE) is currently developing a Proposed Plan (PP) for remediation of designated sources of chlorinated solvents that contribute contamination to the Southwest (SW) Groundwater Plume at the Paducah Gaseous Diffusion Plant (PGDP), in Paducah, KY. The principal contaminants in the SW Plume are trichloroethene (TCE) and other volatile organic compounds (VOCs); these industrial solvents were used and disposed in various facilities and locations at PGDP. In the SW plume area, residual TCE sources are primarily in the fine-grained sediments of the Upper Continental Recharge System (UCRS), a partially saturated zone that delivers contaminants downward into the coarse-grained Regional Gravel Aquifer (RGA). The RGA serves as the significant lateral groundwater transport pathway for the plume. In the SW Plume area, the four main contributing TCE source units are: (1) Solid Waste Management Unit (SWMU) 1 / Oil Landfarm; (2) C-720 Building TCE Northeast Spill Site (SWMU 211A); (3) C-720 Building TCE Southeast Spill Site (SWMU 211B); and (4) C-747 Contaminated Burial Yard (SWMU 4). The PP presents the Preferred Alternatives for remediation of VOCs in the UCRS at the Oil Landfarm and the C-720 Building spill sites. The basis for the PP is documented in a Focused Feasibility Study (FFS) (DOE, 2011) and a Site Investigation Report (SI) (DOE, 2007). The SW plume is currently within the boundaries of PGDP (i.e., does not extend off-site). Nonetheless, reasonable mitigation of the multiple contaminant sources contributing to the SW plume is one of the necessary components identified in the PGDP End State Vision (DOE, 2005). Because of the importance of the proposed actions DOE assembled an Independent Technical Review (ITR) team to provide input and assistance in finalizing the PP.

  13. The Iodine Satellite (iSat) Project Development Towards Critical Design Review (CDR)

    Science.gov (United States)

    Dankanich, John W.; Selby, Michael; Polzin, Kurt A.; Kamhawi, Hani; Hickman, Tyler; Byrne, Larry

    2016-01-01

    Despite the prevalence of Small Satellites in recent years, the systems flown to date have very limited propulsion capability. SmallSats are typically secondary payloads and have significant constraints for volume, mass, and power in addition to limitations on the use of hazardous propellants or stored energy (i.e. high pressure vessels). These constraints limit the options for SmallSat maneuverability. NASA's Space Technology Mission Directorate approved the iodine Satellite flight project for a rapid demonstration of iodine Hall thruster technology in a 12U configuration under the Small Spacecraft Technology Program. The project formally began in FY15 as a partnership between NASA MSFC, NASA GRC, and Busek Co, Inc., with the Air Force supporting the propulsion technology maturation. The team is in final preparation of the Critical Design Review prior to initiating the fabrication and integration phase of the project. The iSat project is on schedule for a launch opportunity in November 2017.

  14. Paducah site annual environmental for 1996

    Energy Technology Data Exchange (ETDEWEB)

    Belcher, G. [ed.

    1997-12-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US Department of Energy (DOE) leased the production areas of the site to the United States Enrichment Corporation (USEC). A subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. The DOE maintains responsibility for the environmental restoration, waste management, and depleted uranium hexafluoride cylinder program activities at the plant through its management contractor, Lockheed Martin Energy Systems. The purpose of this document is to summarize calendar year 1996 environmental monitoring activities for DOE activities at the Paducah Site. The DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities.

  15. Paducah Site annual report for 1995

    Energy Technology Data Exchange (ETDEWEB)

    Belcher, G. [ed.

    1997-01-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US department of Energy (DOE) leased the production areas of the site to the US Enrichment Corporation (USEC). A new subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. DOE maintains responsibility for the environmental restoration, waste management, and enrichment facilities activities at the plant through its management contractor, Lockheed Martin Energy Systems. The purpose of this document is to summarize calendar year 1995 environmental monitoring activities for DOE activities at the Paducah Site. DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities.

  16. Paducah Site annual environmental report for 1994

    International Nuclear Information System (INIS)

    Horak, C.M.

    1996-02-01

    Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US Department of Energy (DOE) leased the production areas of the site to the United States Enrichment Corporation (USEC). A new subsidiary of Lockheed Martin Corporation (formerly Martin Marietta Corporation), Lockheed Martin Utility Services, manages the leased facilities for USEC. DOE maintains responsibility for the environmental restoration and waste management activities at the plant through its management contractor, Lockheed Martin Energy Systems. The purpose of this document is to summarize calendar year 1994 environmental monitoring activities for DOE activities at the Paducah site. DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities

  17. Paducah Site 1997 annual environmental report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US Department of Energy (DOE) leased the production areas of the site to the US Enrichment Corporation (USEC). A subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. The DOE maintains responsibility for the environmental restoration, waste management, and depleted uranium hexafluoride cylinder program activities at the plant through its management contractor. The purpose of this document is to summarize calendar year 1997 environmental monitoring activities for DOE activities at the Paducah Site managed by Lockheed Martin Energy Systems. The DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities.

  18. Paducah Site 1997 annual environmental report

    International Nuclear Information System (INIS)

    1998-12-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US Department of Energy (DOE) leased the production areas of the site to the US Enrichment Corporation (USEC). A subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. The DOE maintains responsibility for the environmental restoration, waste management, and depleted uranium hexafluoride cylinder program activities at the plant through its management contractor. The purpose of this document is to summarize calendar year 1997 environmental monitoring activities for DOE activities at the Paducah Site managed by Lockheed Martin Energy Systems. The DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities

  19. Paducah site annual environmental report for 1996

    International Nuclear Information System (INIS)

    Belcher, G.

    1997-12-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US Department of Energy (DOE) leased the production areas of the site to the United States Enrichment Corporation (USEC). A subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. The DOE maintains responsibility for the environmental restoration, waste management, and depleted uranium hexafluoride cylinder program activities at the plant through its management contractor, Lockheed Martin Energy Systems. The purpose of this document is to summarize calendar year 1996 environmental monitoring activities for DOE activities at the Paducah Site. The DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities

  20. Paducah Site annual report for 1995

    International Nuclear Information System (INIS)

    Belcher, G.

    1997-01-01

    The Paducah Gaseous Diffusion Plant, located in McCracken County, Kentucky, has been producing enriched uranium since 1952. In July 1993, the US department of Energy (DOE) leased the production areas of the site to the US Enrichment Corporation (USEC). A new subsidiary of Lockheed Martin Corporation, Lockheed Martin Utility Services, manages the leased facilities for USEC. DOE maintains responsibility for the environmental restoration, waste management, and enrichment facilities activities at the plant through its management contractor, Lockheed Martin Energy Systems. The purpose of this document is to summarize calendar year 1995 environmental monitoring activities for DOE activities at the Paducah Site. DOE requires all of its facilities to conduct and document such activities annually. This report does not include USEC environmental activities

  1. Regional flood hazard assessment of the Paducah and Portsmouth Gaseous Diffusion Plants

    International Nuclear Information System (INIS)

    Johnson, R.O.; Wang, J.C.; Lee, D.W.

    1991-01-01

    Regional flood-hazard assessments performed for the Paducah and Portsmouth Gaseous Diffusion Plants are reviewed, compared, and contrasted to determine the relationship of probable maximum flood methodology with respect to US Department of Energy design and evaluation guidelines. The Paducah assessment was carried out using probable minimum flood methodology, while the Portsmouth assessment utilized probabilistic techniques. Results indicated that regional flooding along nearby rivers would not inundate either plant, and that the guidelines were satisfied. A comparison of results indicated that the probable minimum flood recurrence interval associated with the Paducah assessment exceeded the 10,000-year requirement of the guidelines, while recurrence intervals obtained in the Portsmouth assessment could be above or below 10,000 years depending on the choice of the probabilistic model used to perform the assessment. It was concluded, based on an analysis of two data points, that smaller watersheds driven by single event storms could be assessed using probabilistic techniques, while probable maximum flood methodology could be applied to larger drainage basins flooded by storm sequences

  2. Paducah Site annual environmental report summary for 1994

    International Nuclear Information System (INIS)

    Horak, C.M.

    1996-02-01

    This pamphlet contains summaries of the environmental programs at the Paducah Gaseous Plant site, environmental monitoring and the results, and the impact of operations on the environment and the public for 1994

  3. Project plan for the background soils project for the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    The Background Soils Project for the Paducah Gaseous Diffusion Plant (BSPP) will determine the background concentration levels of selected naturally occurring metals, other inorganics, and radionuclides in soils from uncontaminated areas in proximity to the Paducah Gaseous Diffusion Plant (PGDP) in Paducah, Kentucky. The data will be used for comparison with characterization and compliance data for soils, with significant differences being indicative of contamination. All data collected as part of this project will be in addition to other background databases established for the PGDP. The BSPP will address the variability of surface and near-surface concentration levels with respect to (1) soil taxonomical types (series) and (2) soil sampling depths within a specific soil profile. The BSPP will also address the variability of concentration levels in deeper geologic formations by collecting samples of geologic materials. The BSPP will establish a database, with recommendations on how to use the data for contaminated site assessment, and provide data to estimate the potential human and health and ecological risk associated with background level concentrations of potentially hazardous constituents. BSPP data will be used or applied as follows.

  4. Project plan for the background soils project for the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    1995-09-01

    The Background Soils Project for the Paducah Gaseous Diffusion Plant (BSPP) will determine the background concentration levels of selected naturally occurring metals, other inorganics, and radionuclides in soils from uncontaminated areas in proximity to the Paducah Gaseous Diffusion Plant (PGDP) in Paducah, Kentucky. The data will be used for comparison with characterization and compliance data for soils, with significant differences being indicative of contamination. All data collected as part of this project will be in addition to other background databases established for the PGDP. The BSPP will address the variability of surface and near-surface concentration levels with respect to (1) soil taxonomical types (series) and (2) soil sampling depths within a specific soil profile. The BSPP will also address the variability of concentration levels in deeper geologic formations by collecting samples of geologic materials. The BSPP will establish a database, with recommendations on how to use the data for contaminated site assessment, and provide data to estimate the potential human and health and ecological risk associated with background level concentrations of potentially hazardous constituents. BSPP data will be used or applied as follows

  5. An aerial radiological survey of the Paducah Gaseous Diffusion Plant and surrounding area, Paducah, Kentucky

    International Nuclear Information System (INIS)

    1992-11-01

    An aerial radiological survey of the Paducah Gaseous Diffusion Plant (PGDP) and surrounding area in Paducah, Kentucky, was conducted during May 15--25, 1990. The purpose of the survey was to measure and document the terrestrial radiological environment at the PGDP and surrounding area for use in effective environmental management and emergency response planning. The aerial survey was flown at an altitude of 61 meters (200 feet) along a series of parallel lines 107 meters (350 feet) apart. The survey encompassed an area of 62 square kilometers (24 square miles), bordered on the north by the Ohio River. The results of the aerial survey are reported as inferred exposure rates at 1 meter above ground level in the form of a gamma radiation contour map. Typical background exposure rates were found to vary from 5 to 12 microroentgens per hour (μR/h). Protactinium-234m, a radioisotope indicative of uranium-238, was detected at several facilities at the PGDR. In support of the aerial survey, ground-based exposure rate and soil sample measurements were obtained at several sites within the survey perimeter. The results of the aerial and ground-based measurements were found to agree within ±15%

  6. Reassessment of liquefaction potential and estimation of earthquake- induced settlements at Paducah Gaseous Diffusion Plant, Paducah, Kentucky. Final report

    International Nuclear Information System (INIS)

    Sykora, D.W.; Yule, D.E.

    1996-04-01

    This report documents a reassessment of liquefaction potential and estimation of earthquake-induced settlements for the U.S. Department of Energy (DOE), Paducah Gaseous Diffusion Plant (PGDP), located southwest of Paducah, KY. The U.S. Army Engineer Waterways Experiment Station (WES) was authorized to conduct this study from FY91 to FY94 by the DOE, Oak Ridge Operations (ORO), Oak Ridge, TN, through Inter- Agency Agreement (IAG) No. DE-AI05-91OR21971. The study was conducted under the Gaseous Diffusion Plant Safety Analysis Report (GDP SAR) Program

  7. Paducah Gaseous Diffusion Plant Environmental report for 1990

    Energy Technology Data Exchange (ETDEWEB)

    Counce-Brown, D. (ed.)

    1991-09-01

    This two-part report, Paducah Gaseous Diffusion Plant Site Environmental Report for 1990, is published annually. It reflects the results of a comprehensive, year-round program to monitor the impact of operations at Paducah Gaseous Diffusion Plant (PGDP) on the area's groundwater and surface waters, soil, air quality, vegetation, and wildlife. In addition, an assessment of the effect of PGDP effluents on the resident human population is made. PGDP's overall goal for environmental management is to protect the environment and PGDP's neighbors and to maintain full compliance with all current regulations. The current environmental strategy is to identify any deficiencies and to develop a system to resolve them. The long-range goal of environmental management is to minimize the source of pollutants, to reduce the formation of waste, and to minimize hazardous waste by substitution of materials.

  8. Paducah Gaseous Diffusion Plant environmental report for 1992

    Energy Technology Data Exchange (ETDEWEB)

    Horak, C.M. [ed.] [Martin Marietta Energy Systems, Inc., Oak Ridge, TN (United States)

    1993-09-01

    This two-part report, Paducah Gaseous Diffusion Plant Environmental Report for 1992, is published annually. It reflects the results of an environmental monitoring program designed to quantify potential increases in the concentration of contaminants and potential doses to the resident human population. The Paducah Gaseous Diffusion Plant (PGDP) overall goal for environmental management is to protect the environment and PGDP`s neighbors and to maintain full compliance with all current regulations. The current environmental strategy is to identify any deficiencies and to develop a system to resolve them. The long-range goal of environmental management is to minimize the source of pollutants, reduce the generation of waste, and minimize hazardous waste by substitution of materials.

  9. Paducah Gaseous Diffusion Plant environmental report for 1992

    International Nuclear Information System (INIS)

    Horak, C.M.

    1993-09-01

    This two-part report, Paducah Gaseous Diffusion Plant Environmental Report for 1992, is published annually. It reflects the results of an environmental monitoring program designed to quantify potential increases in the concentration of contaminants and potential doses to the resident human population. The Paducah Gaseous Diffusion Plant (PGDP) overall goal for environmental management is to protect the environment and PGDP's neighbors and to maintain full compliance with all current regulations. The current environmental strategy is to identify any deficiencies and to develop a system to resolve them. The long-range goal of environmental management is to minimize the source of pollutants, reduce the generation of waste, and minimize hazardous waste by substitution of materials

  10. Paducah Site annual environmental report summary for 1995

    International Nuclear Information System (INIS)

    Belcher, G.

    1997-01-01

    This report contains summaries of the environmental programs at the Paducah Site, as well as the impacts of its operations on the environment and the public for 1995. The results of environmental monitoring are presented. The goal is to keep emissions as low as possible, enhance the strict safety controls that are in place and use state-of-the-art technology to complete environmental remediation projects in the most cost-effective and efficient manner possible

  11. Proposed sale of radioactively contaminated nickel ingots located at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    1995-10-01

    The U.S. Department of Energy (DOE) proposes to sell 8,500 radioactively contaminated nickel ingots (9.350 short tons), currently in open storage at the Paducah Gaseous Diffusion Plant (PGDP), to Scientific Ecology Group, Inc. (SEG) for decontamination and resale on the international market. SEG would take ownership of the ingots when they are loaded for transport by truck to its facility in Oak Ridge, Tennessee. SEG would receive approximately 200 short tons per month over approximately 48 months (an average of 180 ingots per month). The nickel decontamination process specified in SEG's technical proposal is considered the best available technology and has been demonstrated in prototype at SEG. The resultant metal for resale would have contamination levels between 0.3 and 20 becquerel per gram (Bq/g). The health hazards associated with release of the decontaminated nickel are minimal. The activity concentration of the end product would be further reduced when the nickel is combined with other metals to make stainless steel. Low-level radioactive waste from the SEG decontamination process, estimated to be approximately 382 m 3 (12,730 ft), would be shipped to a licensed commercial or DOE disposal facility. If the waste were packaged in 0.23 m 3 -(7.5 ft 3 -) capacity drums, approximately 1,500 to 1,900 drums would be transported over the 48-month contract period. Impacts from the construction of decontamination facilities and the selected site are minimal

  12. An interim report to the manager of the Paducah Gaseous Diffusion Plant from the Paducah Environmental Advisory Committee

    International Nuclear Information System (INIS)

    Jackson, G.D.

    1987-01-01

    The Paducah Environmental Advisory Committee was formed as: (1) an outgrowth of other Environmental Advisory Committees already in existence at Oak Ridge and other Martin Marietta Energy Systems plants; (2) a result of public concern following significant nuclear incidents at Bhopal and Chernobyl; (3) a result of the new direction and commitment of the management of the Paducah Gaseous Diffusion Plant following contract acquisition by Martin Marietta Energy Systems; and (4) a means of reducing and/or preventing local and/or public concern regarding the activities of and potential risks created by PGDP. This report discusses the following issues and concerns of the Committee arrived at through a series of meetings: (1) groundwater monitoring; (2) long-range tails storage; C-404, scrap yrads, and PCB and TCE cleanup; nuclear criticality plan and alarm systems; documentation of historical data regarding hazardous waste burial grounds; dosimeter badges; and asbestos handling and removal

  13. An interim report to the manager of the Paducah Gaseous Diffusion Plant from the Paducah Environmental Advisory Committee

    International Nuclear Information System (INIS)

    Jackson, G.D.

    1987-10-01

    The Paducah Environmental Advisory Committee was formed as: (1) an outgrowth of other Environmental Advisory Committees already in existence at Oak Ridge and other Martin Marietta Energy Systems plants; (2) a result of public concern following significant nuclear incidents at Bhopal and Chernobyl; (3) a result of the new direction and commitment of the management of the Paducah Gaseous Diffusion Plant following contract acquisition by Martin Marietta Energy Systems; and (4) a means of reducing and/or preventing local and/or public concern regarding the activities of and potential risks created by PGDP. This report discusses the following issues and concerns of the Committee arrived at through a series of meetings: (1) groundwater monitoring; (2) long-range tails storage; C-404, scrap yrads, and PCB and TCE cleanup; nuclear criticality plan and alarm systems; documentation of historical data regarding hazardous waste burial grounds; dosimeter badges; and asbestos handling and removal

  14. 76 FR 5147 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-01-28

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  15. 77 FR 59598 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-09-28

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  16. 75 FR 54600 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-09-08

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  17. 75 FR 66074 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-10-27

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  18. 75 FR 24686 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-05-05

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  19. 76 FR 80355 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-12-23

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... make recommendations to DOE-EM and site management in the areas of environmental restoration, waste...

  20. 75 FR 9404 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-03-02

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  1. 77 FR 43583 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-07-25

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  2. 75 FR 61711 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-10-06

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  3. 75 FR 82002 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-12-29

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  4. 76 FR 61350 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-10-04

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... make recommendations to DOE-EM and site management in the areas of environmental restoration, waste...

  5. 77 FR 2282 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-01-17

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... the Environmental Management Site-Specific Advisory Board, Paducah. This notice announces the... Management Officer. [FR Doc. 2012-831 Filed 1-12-12; 4:15 pm] BILLING CODE 6405-01-P ...

  6. 76 FR 48148 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-08-08

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  7. Local drainage analyses of the Paducah and Portsmouth Gaseous Diffusion Plants during an extreme storm

    International Nuclear Information System (INIS)

    Johnson, R.O.; Wang, J.C.; Lee, D.W.

    1993-01-01

    Local drainage analyses have been performed for the Paducah and Portsmouth Gaseous Diffusion Plants during an extreme storm having an approximate 10,000-yr recurrence interval. This review discusses the methods utilized to accomplish the analyses in accordance with US Department of Energy (DOE) design and evaluation guidelines, and summarizes trends, results, generalizations, and uncertainties applicable to other DOE facilities. Results indicate that some culverts may be undersized, and that the storm sewer system cannot drain the influx of precipitation from the base of buildings. Roofs have not been designed to sustain ponding when the primary drainage system is clogged. Some underground tunnels, building entrances, and ground level air intakes may require waterproofing

  8. On-line vibration and analysis system at the Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Herricks, D.M.; Strunk, W.D.

    1987-11-01

    The enrichment facility in Paducah, KY uses a unique hard-wired vibration monitoring and analysis system for gaseous diffusion equipment. The axial flow and centrifugal flow compressors used in uranium enrichment range in size from 6 feet in diameter to less than one foot in diameter. These compressors must operate smoothly and safely, without breech of containment, since the working fluid of gaseous diffusion is gaseous UF 6 . The condition of 1925 compressors is monitored by use of the 2500 point vibration analysis system. Since the failure mechanisms of the compressors are well known and documented, only one accelerometer per machine is needed for most machines. The system is completely automated and can generate spectra or broadband levels in either acceleration or velocity units. Levels are stored for historical review. The analyst can, via a custom telecommunications link, view and analyze data from all monitored points with an office PC. 4 figs

  9. Inorganic soil and groundwater chemistry near Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    Moore, G.K.

    1995-03-01

    Near-surface soils, boreholes, and sediments near the Paducah Gaseous Diffusion Plant (PGDP) were sampled in 1989-91 as were monitoring wells, TVA wells, and privately-owned wells. Most wells were sampled two or three times. The resulting chemical analyses have been published in previous reports and have been previously described (CH2M HILL 1991, 1992; Clausen et al. 1992). The two reports by CH2M HILL are controversial, however, because, the concentrations of some constituents were reported to exceed background levels or drinking water standards and because both on-site (within the perimeter fence at PGDP) and off-site pollution was reported to have occurred. The groundwater samples upon which these interpretations were based may not be representative, however. The CH2M HILL findings are discussed in the report. The purpose of this report is to characterize the inorganic chemistry of groundwater and soils near PGDP, using data from the CH2M HILL reports (1991, 1992), and to determine whether or not any contamination has occurred. The scope is limited to analysis and interpretation of data in the CH2M HILL reports because previous interpretations of these data may not be valid, because samples were collected in a relatively short period of time at several hundred locations, and because the chemical analyses are nearly complete. Recent water samples from the same wells were not considered because the characterization of inorganic chemistry for groundwater and soil requirements only one representative sample and an accurate analysis from each location

  10. Inorganic soil and groundwater chemistry near Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Moore, G.K. [Tennessee Univ., Knoxville, TN (United States)

    1995-03-01

    Near-surface soils, boreholes, and sediments near the Paducah Gaseous Diffusion Plant (PGDP) were sampled in 1989-91 as were monitoring wells, TVA wells, and privately-owned wells. Most wells were sampled two or three times. The resulting chemical analyses have been published in previous reports and have been previously described (CH2M HILL 1991, 1992; Clausen et al. 1992). The two reports by CH2M HILL are controversial, however, because, the concentrations of some constituents were reported to exceed background levels or drinking water standards and because both on-site (within the perimeter fence at PGDP) and off-site pollution was reported to have occurred. The groundwater samples upon which these interpretations were based may not be representative, however. The CH2M HILL findings are discussed in the report. The purpose of this report is to characterize the inorganic chemistry of groundwater and soils near PGDP, using data from the CH2M HILL reports (1991, 1992), and to determine whether or not any contamination has occurred. The scope is limited to analysis and interpretation of data in the CH2M HILL reports because previous interpretations of these data may not be valid, because samples were collected in a relatively short period of time at several hundred locations, and because the chemical analyses are nearly complete. Recent water samples from the same wells were not considered because the characterization of inorganic chemistry for groundwater and soil requirements only one representative sample and an accurate analysis from each location.

  11. Environmental assessment for the construction and operation of waste storage facilities at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    1994-06-01

    DOE is proposing to construct and operate 3 waste storage facilities (one 42,000 ft 2 waste storage facility for RCRA waste, one 42,000 ft 2 waste storage facility for toxic waste (TSCA), and one 200,000 ft 2 mixed (hazardous/radioactive) waste storage facility) at Paducah. This environmental assessment compares impacts of this proposed action with those of continuing present practices aof of using alternative locations. It is found that the construction, operation, and ultimate closure of the proposed waste storage facilities would not significantly affect the quality of the human environment within the meaning of NEPA; therefore an environmental impact statement is not required

  12. Partnering efforts at the Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Warren, C.B.

    1995-01-01

    Before individuals or agencies can effectively work together to solve common problems, they must first agree on exactly what those problems are and establish common goals and methods that will lead to mutually acceptable solutions. Then, they must make a conscientious effort to form a cohesive team that focuses on the established goals and deemphasize traditional roles, which may in some instances be considered adversarial. This kind of teamwork/partnering process can be more difficult, though not impossible, to achieve in cases where there are traditional (real or imagined) adversarial relationships between the parties, i.e. regulator vs. regulated. The US Department of Energy Site Office (DOE) at Paducah, Kentucky, the Kentucky Department of Environmental Protection (KDEP) and the US Environmental Protection Agency, Region IV (EPA) have made t strides toward teamwork and partnering at DOE's Paducah Gaseous Diffusion Plant. They have accomplished this in a number of ways, which will be discussed in greater detail but first and foremost, the agencies agreed up front that they had mutual goals and interests. These goals are to protect public health and the environment in a cost-effective and timely manner, taking care to make the wisest use of public resources (tax dollars); to evaluate and minimize risks, and to achieve ''Win-Win'' for all parties concerned

  13. Paducah Gaseous Diffusion Plant Annual Site Environmental Report for 1993

    International Nuclear Information System (INIS)

    1994-10-01

    The purpose of this document is to summarize effluent monitoring and environmental surveillance results and compliance with environmental laws, regulations, and orders at the Paducah Gaseous Diffusion Plant (PGDP). Environmental monitoring at PGDP consists of two major activities: effluent monitoring and environmental surveillance. Effluent monitoring is direct measurement or the collection and analysis of samples of liquid and gaseous discharges to the environment. Environmental surveillance is direct measurement or the collection and analysis of samples of air, water, soil, foodstuff, biota, and other media. Environmental monitoring is performed to characterize and quantify contaminants, assess radiation exposures of members of the public, demonstrate compliance with applicable standards and permit requirements, and detect and assess the effects (if any) on the local environment. Multiple samples are collected throughout the year and are analyzed for radioactivity, chemical content, and various physical attributes

  14. Paducah Gaseous Diffusion Plant environmental report for 1989

    Energy Technology Data Exchange (ETDEWEB)

    Turner, J.W. (ed.) (Martin Marietta Energy Systems, Inc., Oak Ridge, TN (USA))

    1990-10-01

    This two-part environmental report is published annually. It reflects the results of a comprehensive, year-round program to monitor the impact of operations at Paducah Gaseous Diffusion Plant (PGDP) on the area's groundwater and surface waters, soil, air quality, vegetation, and wildlife. In addition, an assessment of the effect of PGDP effluents on the resident human population is made. PGDP's overall goal for environmental management is to protect the environment and PGDP's neighbors and to maintain full compliance with all current regulations. The current environmental strategy is to identify any deficiencies and to develop a system to resolve them. The long-range goal of environmental management is to minimize the source of pollutants, to reduce the formation of waste, and to minimize hazardous waste by substitution of materials. 36 refs.

  15. Environmental assessment for the construction and operation of waste storage facilities at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-06-01

    DOE is proposing to construct and operate 3 waste storage facilities (one 42,000 ft{sup 2} waste storage facility for RCRA waste, one 42,000 ft{sup 2} waste storage facility for toxic waste (TSCA), and one 200,000 ft{sup 2} mixed (hazardous/radioactive) waste storage facility) at Paducah. This environmental assessment compares impacts of this proposed action with those of continuing present practices aof of using alternative locations. It is found that the construction, operation, and ultimate closure of the proposed waste storage facilities would not significantly affect the quality of the human environment within the meaning of NEPA; therefore an environmental impact statement is not required.

  16. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1993 to December 1994

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A. [ed.

    1996-05-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). The PGDP BMP was implemented in 1987 by the University of Kentucky. Research staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) served as reviewers and advisers to the University of Kentucky. Beginning in fall 1991, ESD added data collection and report preparation to its responsibilities for the PGDP BMP. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, (3) document the effects of pollution abatement facilities on stream biota, and (4) recommend any program improvements that would increase effluent treatability. In September 1992, a renewed Kentucky Pollutant Discharge Elimination System (KPDES) permit was issued to PGDP. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report includes ESD activities occurring from December 1993 to December 1994, although activities conducted outside this time period are included as appropriate.

  17. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1993 to December 1994

    International Nuclear Information System (INIS)

    Kszos, L.A.

    1996-05-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). The PGDP BMP was implemented in 1987 by the University of Kentucky. Research staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) served as reviewers and advisers to the University of Kentucky. Beginning in fall 1991, ESD added data collection and report preparation to its responsibilities for the PGDP BMP. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, (3) document the effects of pollution abatement facilities on stream biota, and (4) recommend any program improvements that would increase effluent treatability. In September 1992, a renewed Kentucky Pollutant Discharge Elimination System (KPDES) permit was issued to PGDP. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report includes ESD activities occurring from December 1993 to December 1994, although activities conducted outside this time period are included as appropriate

  18. Depleted uranium hexafluoride management program : data compilation for the Paducah site

    International Nuclear Information System (INIS)

    Hartmann, H.

    2001-01-01

    This report is a compilation of data and analyses for the Paducah site, near Paducah, Kentucky. The data were collected and the analyses were done in support of the U.S. Department of Energy (DOE) 1999 Programmatic Environmental Impact Statement for Alternative Strategies for the Long-Term Management and Use of Depleted Uranium Hexafluoride (DOE/EIS-0269). The report describes the affected environment at the Paducah site and summarizes potential environmental impacts that could result from conducting the following depleted uranium hexafluoride (UF 6 ) activities at the site: continued cylinder storage, preparation of cylinders for shipment, conversion, and long-term storage. DOE's preferred alternative is to begin converting the depleted UF 6 inventory as soon as possible to either uranium oxide, uranium metal, or a combination of both, while allowing for use of as much of this inventory as possible

  19. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) 99 Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD

  20. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant

    Energy Technology Data Exchange (ETDEWEB)

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) [sup 99]Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD.

  1. Bioavailability study for the Paducah Gaseous Diffusion Plant

    Energy Technology Data Exchange (ETDEWEB)

    Phipps, T.L.; Kszos, L.A.

    1996-08-01

    The overall purpose of this plan is to assess the bioavailability of metals in the continuous and intermittent outfalls. The results may be used to determine alternative metal limits that more appropriately measure the portion of metal present necessary for toxicity to aquatic life. These limits must remain protective of in-stream aquatic life; thus, the highest concentration of metal in the water will be determined concurrently with an assessment of acute or chronic toxicity on laboratory tests. Using the method developed by the Kentucky Division of Water (KDOW), biomonitoring results and chemical data will be used to recommend alternative metal limits for the outfalls of concern. The data will be used to meet the objectives of the study: (1) evaluate the toxicity of continuous outfalls and intermittent outfalls at Paducah Gaseous Diffusion Plant; (2) determine the mean ratio of dissolved to Total Recoverable metal for Cd, Cr, Cu, Pb, Ni, and Zn in the continuous and intermittent outfalls; (3) determine whether the concentration of total recoverable metal discharged causes toxicity to fathead minnows and /or Ceriodaphnia; and (4) determine alternative metal limits for each metal of concern (Cd, Cr, Cu, Pb, Ni, and Zn).

  2. Paducah Gaseous Diffusion Plant Northwest Plume interceptor system evaluation

    International Nuclear Information System (INIS)

    Laase, A.D.; Clausen, J.L.

    1998-01-01

    The Paducah Gaseous Diffusion Plant (PGDP) recently installed an interceptor system consisting of four wells, evenly divided between two well fields, to contain the Northwest Plume. As stated in the Northwest Plume Record of Decision (ROD), groundwater will be pumped at a rate to reduce further contamination and initiate control of the northwest contaminant plume. The objective of this evaluation was to determine the optimum (minimal) well field pumping rates required for plume hotspot containment. Plume hotspot, as defined in the Northwest Plume ROD and throughout this report, is that portion of the plume with trichloroethene (TCE) concentrations greater than 1,000 microg/L. An existing 3-dimensional groundwater model was modified and used to perform capture zone analyses of the north and south interceptor system well fields. Model results suggest that the plume hotspot is not contained at the system design pumping rate of 100 gallons per minute (gal/min) per well field. Rather, the modeling determined that north and south well field pumping rates of 400 and 150 gal/min, respectively, are necessary for plume hotspot containment. The difference between the design and optimal pumping rates required for containment can be attributed to the discovery of a highly transmissive zone in the vicinity of the two well fields

  3. Preliminary study of PCBs in raccoons living on or near the Paducah Gaseous Diffusion Plant, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Halbrook, Richard S. [Southern Illinois Univ., Carbondale, IL (United States). Dept. of Zoology. Cooperative Wildlife Research Lab. Kentucky Research Consortium for Energy and Environment

    2016-01-15

    The “Ecological Monitoring at the Paducah Gaseous Diffusion Plant: Historical Evaluation and Guidelines for Future Monitoring” report (Halbrook, et al. 2007) recommended the raccoon as a species for study at the Paducah Gaseous Diffusion Plant (PGDP). This species was selected to fill data gaps in ecological resources and provide resource managers with knowledge that will be valuable in making decisions and implementing specific actions to safeguard ecological resources and reduce human exposure. The current paper reports results of a preliminary evaluation to establish protocols for collection of tissues and initial screening of polychlorinated biphenyls (PCBs) in raccoons collected near the PGDP. These data are useful in developing future more comprehensive studies.

  4. Experiment Simulation Configurations Used in DUNE CDR

    Energy Technology Data Exchange (ETDEWEB)

    Alion, T. [Univ. of South Carolina, Columbia, SC (United States); Black, J. J. [Univ. of Warwick, Coventry (United Kingdom); Bashyal, A. [Oregon State Univ., Corvallis, OR (United States); Bass, M. [Univ. of Oxford (United Kingdom); Bishai, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Cherdack, D. [Colorado State Univ., Fort Collins, CO (United States); Diwan, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Djurcic, Z. [Argonne National Lab. (ANL), Argonne, IL (United States); Evans, J. [Univ. of Manchester (United Kingdom); Fernandez-Martinez, E. [Madrid Autonama Univ. (Spain); Fields, L. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Fleming, B. [Yale Univ., New Haven, CT (United States); Gran, R. [Univ. of Minnesota, Duluth, MN (United States); Guenette, R. [Univ. of Oxford (United Kingdom); Hewes, J. [Univ. of Manchester (United Kingdom); Hogan, M. [Colorado State Univ., Fort Collins, CO (United States); Hylen, J. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Junk, T. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Kohn, S. [Univ. of California, Berkeley, CA (United States); LeBrun, P. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Lundberg, B. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Marchionni, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Morris, C. [Univ. of California, Berkeley, CA (United States); Papadimitriou, V. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Rameika, R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Rucinski, R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Soldner-Rembold, S. [Univ. of Manchester (United Kingdom); Sorel, M. [Spanish National Research Council (CSIC), Valencia (Spain). Univ. of Valencia (UV), Inst. de Fisica Corpuscular; Urheim, J. [Indiana Univ., Bloomington, IN (United States); Viren, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Whitehead, L. [Univ. of Houston, TX (United States); Wilson, R. [Colorado State Univ., Fort Collins, CO (United States); Worcester, E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Zeller, G. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2016-06-30

    The LBNF/DUNE CDR describes the proposed physics program and experimental design at the conceptual design phase. Volume 2, entitled The Physics Program for DUNE at LBNF, outlines the scientific objectives and describes the physics studies that the DUNE collaboration will perform to address these objectives. The long-baseline physics sensitivity calculations presented in the DUNE CDR rely upon simulation of the neutrino beam line, simulation of neutrino interactions in the far detector, and a parameterized analysis of detector performance and systematic uncertainty. The purpose of this posting is to provide the results of these simulations to the community to facilitate phenomenological studies of long-baseline oscillation at LBNF/DUNE. Additionally, this posting includes GDML of the DUNE single-phase far detector for use in simulations. DUNE welcomes those interested in performing this work as members of the collaboration, but also recognizes the benefit of making these configurations readily available to the wider community.

  5. XML Schema Guide for Primary CDR Submissions

    Science.gov (United States)

    This document presents the extensible markup language (XML) schema guide for the Office of Pollution Prevention and Toxics’ (OPPT) e-CDRweb tool. E-CDRweb is the electronic, web-based tool provided by Environmental Protection Agency (EPA) for the submission of Chemical Data Reporting (CDR) information. This document provides the user with tips and guidance on correctly using the version 1.7 XML schema. Please note that the order of the elements must match the schema.

  6. Assessment of the influences of groundwater colloids on the migration of technetium-99 at the Paducah Gaseous Diffusion Plant Site in Paducah, Kentucky

    International Nuclear Information System (INIS)

    Gu, B.; McDonald, J.A.; McCarthy, J.F.; Clausen, J.L.

    1994-07-01

    This short report summarizes the influences of groundwater colloids on the migration/transport of 99 Tc at the Paducah Gaseous Diffusion Plant (PGDP) site in Paducah, Kentucky. Limited data suggest that inorganic colloidal materials (e.g., aluminosilicate clay minerals) may not play a significant role in the retention and transport of Tc. Studies by size fractionation reveal that both Tc and natural organic matter (NOM) are largely present in the -8 mol/L or parts per billion), regardless of the redox conditions, Tc will stay in solution phase as TC(IV) or Tc(VII). The mechanisms of adsorption/association vs precipitation must be understood under reduced and low Tc conditions so that strategic plans for remediation of Tc contaminated soils and groundwaters can be developed

  7. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    process and enucleate the nucleus pulposus totally, through an ... 20yrs. 21-. 30yrs. 31-. 40yrs. 41-. 50yrs. 51-. 60yrs. 61-. 70yrs. 71-. 80yrs. Total ..... Gallucci M, Limbucci N, Zugaro L, Barile A,. Stavroulis E ... Systematic review. European ...

  8. Laniyan et al (16).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Keyword: Arsenic, Absorption, Contamination, Phytoremediation, Filtrates ttlaniyan@yahoo.com ... Arsenic (As) a toxic metal occurs naturally in soil and minerals and may get ..... cadmium toxicity in plants: A review. Environ Pollution. 98(1): ...

  9. Safety analysis report on the ''Paducah Tiger'' protective overpack for 10-ton cylinders of uranium hexafluoride

    International Nuclear Information System (INIS)

    Stitt, D.H.

    1975-01-01

    The ''Paducah Tiger'' is a protective overpack used in shipment of 10-ton cylinders of enriched UF 6 . The calculations and tests are described which made and which indicate that the overpack is in compliance with the type B packaging requirements of ERDA Manual Chapter 0529 and Title 10 Code Federal Regulations Part 71. (U.S.)

  10. 78 FR 65389 - United States Enrichment Corporation, Paducah Gaseous Diffusion Plant

    Science.gov (United States)

    2013-10-31

    ..., USEC notified the NRC of its decision to permanently cease uranium enrichment activities at the PGDP... Accession Nos. ML13105A010 and ML13176A151, respectively. NRC's PDR: You may examine and purchase copies of... in Paducah, Kentucky, using the gaseous [[Page 65390

  11. 78 FR 66779 - United States Enrichment Corporation, Paducah Gaseous Diffusion Plant, Including On-Site Leased...

    Science.gov (United States)

    2013-11-06

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-82,862] United States Enrichment..., applicable to workers of United States Enrichment Corporation, Paducah Gaseous Diffusion Plant, including on... were engaged in the production of low enrichment uranium. The company reports that workers leased from...

  12. 78 FR 73519 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-12-06

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  13. 78 FR 45518 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-07-29

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  14. 78 FR 38969 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-06-28

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  15. 77 FR 31837 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-05-30

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. No. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  16. 78 FR 63172 - Environmental Management Site-Specific Advisory Board, Paducah; Meeting

    Science.gov (United States)

    2013-10-23

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  17. 78 FR 54460 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-09-04

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  18. 78 FR 25064 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-04-29

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  19. 78 FR 78952 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-12-27

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  20. 78 FR 16260 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-03-14

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. No. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  1. 78 FR 32640 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-05-31

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  2. 77 FR 4799 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-01-31

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  3. 78 FR 26635 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-05-07

    ...On April 29, 2013, the Department of Energy (DOE) published a notice of open meeting announcing a meeting on May 16, 2013 of the Environmental Management Site-Specific Advisory Board, Paducah (78 FR 25064). This document makes a correction to that notice.

  4. 78 FR 7767 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2013-02-04

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  5. Real Time Demonstration Project XRF Performance Evaluation Report for Paducah Gaseous Diffusion Plant AOC 492

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Robert L [Argonne National Laboratory

    2008-04-03

    This activity was undertaken to demonstrate the applicability of market-available XRF instruments to quantify metal concentrations relative to background and risk-based action and no action levels in Paducah Gaseous Diffusion Plant (PGDP) soils. As such, the analysis below demonstrates the capabilities of the instruments relative to soil characterization applications at the PGDP.

  6. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    treatment of hyperparathyroidism and the remaining 9 cases diagnosed during the management of thyroid disorders or cervical nodules . These authors have therefore suggested that the old dictum stating that lateral aberrant thyroid represents metastatic cancer should be either modified or removed in review texts and.

  7. The CLIC ILD CDR Geometry for the CDR Monte Carlo Mass Production

    CERN Document Server

    Muennich, A

    2012-01-01

    The CLIC ILD CDR detector for the Monte Carlo event simulation is described in a GEANT4 application, with some parameters available in a database and XML files. This makes it difficult to quickly “look up” interesting parameters of the detector geometry used for the simulation. This note summarises the important geometrical parameters and some details of the implemented detector components.

  8. OCCUPATIONAL EXPOSURE TO TRICHLOROETHYLENE AND CANCER RISK FOR WORKERS AT THE PADUCAH GASEOUS DIFFUSION PLANT

    Science.gov (United States)

    BAHR, DEBRA E.; ALDRICH, TIMOTHY E.; SEIDU, DAZAR; BRION, GAIL M.; TOLLERUD, DAVID J.; MULDOON, SUSAN; REINHART, NANCY; YOUSEEFAGHA, AHMED; MCKINNEY, PAUL; HUGHES, THERESE; CHAN, CAROLINE; RICE, CAROL; BREWER, DAVID E.; FREYBERG, RONALD W.; MOHLENKAMP, ADRIANE MOSER; HAHN, KRISTEN; HORNUNG, RICHARD; HO, MONA; DASTIDAR, ANIRUDDHA; FREITAS, SAMANTHA; SAMAN, DANIEL; RAVDAL, HEGE; SCUTCHFIELD, DOUGLAS; EGER, KENNETH J.; MINOR, STEVE

    2016-01-01

    Objective The Paducah Gaseous Diffusion Plant (PGDP) became operational in 1952; it is located in the western part of Kentucky. We conducted a mortality study for adverse health effects that workers may have suffered while working at the plant, including exposures to chemicals. Materials and Methods We studied a cohort of 6820 workers at the PGDP for the period 1953 to 2003; there were a total of 1672 deaths to cohort members. Trichloroethylene (TCE) is a specific concern for this workforce; exposure to TCE occurred primarily in departments that clean the process equipment. The Life Table Analysis System (LTAS) program developed by NIOSH was used to calculate the standardized mortality ratios for the worker cohort and standardized rate ratio relative to exposure to TCE (the U.S. population is the referent for age-adjustment). LTAS calculated a significantly low overall SMR for these workers of 0.76 (95% CI: 0.72–0.79). A further review of three major cancers of interest to Kentucky produced significantly low SMR for trachea, bronchus, lung cancer (0.75, 95% CI: 0.72–0.79) and high SMR for Non-Hodgkin's lymphoma (NHL) (1.49, 95% CI: 1.02–2.10). Results No significant SMR was observed for leukemia and no significant SRRs were observed for any disease. Both the leukemia and lung cancer results were examined and determined to reflect regional mortality patterns. However, the Non-Hodgkin's Lymphoma finding suggests a curious amplification when living cases are included with the mortality experience. Conclusions Further examination is recommended of this recurrent finding from all three U.S. Gaseous Diffusion plants. PMID:21468904

  9. Safety analysis report on the ''Paducah Tiger'' protective overpack for 10-ton cylinders of uranium hexafluoride. Supplement 1

    International Nuclear Information System (INIS)

    Stitt, D.H.

    1977-01-01

    This supplement details design changes made to the ''Paducah Tiger'' since the issue date of the SAR, June 16, 1976. A 3 / 8 -inch thick, 304L stainless steel plate has been added on the valve end of existing and future overpacks to provide increased puncture resistance and the overpack cavity has been modified to preclude incorrect loading of the type 48X cylinder. Temperature profiles of the ''Paducah Tiger'' during the 30-minute fire test are included

  10. XML Schema Guide for Secondary CDR Submissions

    Science.gov (United States)

    This document presents the extensible markup language (XML) schema guide for the Office of Pollution Prevention and Toxics’ (OPPT) e-CDRweb tool. E-CDRweb is the electronic, web-based tool provided by Environmental Protection Agency (EPA) for the submission of Chemical Data Reporting (CDR) information. This document provides the user with tips and guidance on correctly using the version 1.1 XML schema for the Joint Submission Form. Please note that the order of the elements must match the schema.

  11. Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.

    Science.gov (United States)

    Apgar, James R; Mader, Michelle; Agostinelli, Rita; Benard, Susan; Bialek, Peter; Johnson, Mark; Gao, Yijie; Krebs, Mark; Owens, Jane; Parris, Kevin; St Andre, Michael; Svenson, Kris; Morris, Carl; Tchistiakova, Lioudmila

    2016-10-01

    Antibodies are an important class of biotherapeutics that offer specificity to their antigen, long half-life, effector function interaction and good manufacturability. The immunogenicity of non-human-derived antibodies, which can be a major limitation to development, has been partially overcome by humanization through complementarity-determining region (CDR) grafting onto human acceptor frameworks. The retention of foreign content in the CDR regions, however, is still a potential immunogenic liability. Here, we describe the humanization of an anti-myostatin antibody utilizing a 2-step process of traditional CDR-grafting onto a human acceptor framework, followed by a structure-guided approach to further reduce the murine content of CDR-grafted antibodies. To accomplish this, we solved the co-crystal structures of myostatin with the chimeric (Protein Databank (PDB) id 5F3B) and CDR-grafted anti-myostatin antibody (PDB id 5F3H), allowing us to computationally predict the structurally important CDR residues as well as those making significant contacts with the antigen. Structure-based rational design enabled further germlining of the CDR-grafted antibody, reducing the murine content of the antibody without affecting antigen binding. The overall "humanness" was increased for both the light and heavy chain variable regions.

  12. Development of critical digital review procedure

    International Nuclear Information System (INIS)

    Huang Huiwen; Liao Benching; Tseng Maosheng; Chung Hsianghan; Cheng Tsungchieh; Chen Minghuei

    2011-01-01

    This paper describes the critical digital review (CDR) procedure, which was developed by Institute of Nuclear Energy Research (INER), and sponsored by Taiwan Power Company (TPC). A preliminary CDR application experience which was performed by INER, is also described in this paper. Currently, CDR becomes one of the policies for digital Instrumentation and Control (I and C) system replacement in TPC. The contents of this CDR procedure include: Scope, Responsibility, Operation Procedure, Operation Flow Chart, CDR review items. The 'CDR Review Items' chapter proposes optional review items, including the comparison of the design change, Software Verification and Validation (SV and V), Failure Mode and Effects Analysis (FMEA), Evaluation of Watchdog Timer, Evaluation of Electromagnetic Compatibility (EMC), Evaluation of Grounding for System/Component, Seismic Evaluation, HFE Evaluation, Witness and Inspection, Lessons Learnt from the Digital I and C Failure Events. Since CDR has become a TPC policy, Chin Shan Nuclear Power Plant (NPP) performed the CDR practice of Automatic Voltage Regulator (AVR) digital I and C replacement, even though the project had been on the half way. The major review items of this CDR were: the comparison of the design change, SV and V, FMEA, Evaluation of Watchdog Timer, Evaluation of Electromagnetic Compatibility (EMC), Evaluation of Grounding for System/ Component, Witness and Inspection, Lessons Learnt from the Digital I and C Failure Events. The experience of the CDR showed the importance of preparation of the documents by the vendor. This means the communication with the vendors for the bid preparation is crucial. (author)

  13. Dose Modeling Evaluations and Technical Support Document for the Authorized Limits Request for the C-746-U Landfill at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    Boerner, A. J.; Maldonado, D. G.; Hansen, Tom

    2012-01-01

    This report contains the technical basis in support of the DOE's derivation of Authorized Limits (ALs) for the DOE Paducah C-746-U Landfill. A complete description of the methodology, including an assessment of the input parameters, model inputs, and results is provided in this report. This report also provides initial recommendations on applying the derived soil guidelines. The ORISE-derived soil guidelines are specifically applicable to the Landfill at the end of its operational life. A suggested 'upper bound' multiple of the derived soil guidelines for individual shipments is provided

  14. Dose Modeling Evaluations and Technical Support Document for the Authorized Limits Request for the C-746-U Landfill at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Boerner, A. J. [IEAVP, ORISE, Oak Ridge, TN (United States); Maldonado, D. G. [IEAVP, ORISE, Oak Ridge, TN (United States; Hansen, Tom [Ameriphysics, LLC (United States)

    2012-06-01

    This report contains the technical basis in support of the DOE?s derivation of Authorized Limits (ALs) for the DOE Paducah C-746-U Landfill. A complete description of the methodology, including an assessment of the input parameters, model inputs, and results is provided in this report. This report also provides initial recommendations on applying the derived soil guidelines. The ORISE-derived soil guidelines are specifically applicable to the Landfill at the end of its operational life. A suggested 'upper bound' multiple of the derived soil guidelines for individual shipments is provided.

  15. Paducah Gaseous Diffusion Plant Annual Site Environmental Report summary for 1993

    International Nuclear Information System (INIS)

    1994-11-01

    This report contains summaries of the environmental programs at Paducah Gaseous Diffusion Plant, environmental monitoring and the results, and the impact of operations on the environment and the public for 1993. The environmental monitoring program at Paducah includes effluent monitoring and environmental surveillance. Effluent monitoring is measurement of releases as they occur. Contaminants are released through either airborne emissions or liquids discharged from the plant. These releases occur as part of normal site operations, such as cooling water discharged from the uranium enrichment cascade operations or airborne releases from ventilation systems. In the event of system failure, this monitoring provides timely warning so that corrective action can be taken before releases reach an unsafe level. Environmental surveillance tracks the dispersion of materials into the environment after they have been released. This involves the collection of samples from various media, such as water, soil, vegetation, and food crops, and the analysis of these samples for certain radionuclides, chemicals, and metals

  16. Environmental Restoration Site-Specific Plan for the Paducah Gaseous Diffusion Plant, FY 93

    International Nuclear Information System (INIS)

    1993-01-01

    This report provides an overview of the major Environmental Restoration (ER) concerns at Paducah Gaseous Diffusion Plant (PGDP). The identified solid waste management units at PGDP are listed. In the Department of Energy (DOE) Five Year Plan development process, one or more waste management units are addressed in a series of activity data sheets (ADSs) which identify planned scope, schedule, and cost objectives that are representative of the current state of planned technical development for individual or multiple sites

  17. Dual wall reverse circulation drilling with multi-level groundwater sampling for groundwater contaminant plume delineation at Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    Smuin, D.R.; Morti, E.E.; Zutman, J.L.; Pickering, D.A.

    1995-01-01

    Dual wall reverse circulation (DWRC) drilling was used to drill 48 borings during a groundwater contaminant investigation at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky. This method was selected as an alternative to conventional hollow stem auger drilling for a number of reasons, including the expectation of minimizing waste, increasing the drilling rate, and reducing the potential for cross contamination of aquifers. Groundwater samples were collected from several water-bearing zones during drilling of each borehole. The samples were analyzed for volatile organic compounds using a field gas chromatograph. This approach allowed the investigation to be directed using near-real-time data. Use of downhole geophysical logging, in conjunction with lithologic descriptions of borehole cuttings, resulted in excellent correlation of the geology in the vicinity of the contaminant plume. The total volume of cuttings generated using the DWRC drilling method was less than half of what would have been produced by hollow stem augering; however, the cuttings were recovered in slurry form and had to be dewatered prior to disposal. The drilling rate was very rapid, often approaching 10 ft/min; however, frequent breaks to perform groundwater sampling resulted in an average drilling rate of < 1 ft/min. The time required for groundwater sampling could be shortened by changing the sampling methodology. Analytical results indicated that the drilling method successfully isolated the various water bearing zones and no cross contamination resulted from the investigation

  18. Evaluation of the proposed pilot groundwater pump and treat demonstration for the Paducah Gaseous Diffusion Plant. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Bodenstein, G.W.; Bonczek, R.R.; Early, T.O.; Hale, T.B.; Huff, D.D.; Nickelson, M.D.; Rightmire, C.T.

    1992-11-01

    This report contains the evaluation and recommendations of a Groundwater Corrective Actions Review Team. The primary goal is to evaluate the technical merit of and the need to implement a proposed groundwater pump-and-treat demonstration project for the Northwest contaminant plume at Paducah, Kentucky. A key distinction recognized by the review team is that the proposed project is intended to be a full-scale hydraulic containment of contaminants migrating from the sources of the plume, not plume remediation. The key questions incorporated into this plan are whether (1) dense, nonaqueous-phase liquids (DNAPLS) are present in the Regional Gravel Aquifer (RGA) at the source of the plume and (2) {sup 99}Tc removal must be included as part of any groundwater treatment process. The first question cannot be answered until the contaminant sources are better defined; the second question requires further risk assessment and/or a policy decision by DOE. Technical evaluation by the review team suggests that the recommended course of action be to modify the proposed work plan to include accurate identification of the sources of contaminants and vertical distribution of contaminants within the Northwest plume before a decision is made on the preferred source-control option. If DNAPLs are not present in the RGA, removal or containment of the sources is recommended. If DNAPLs are present, then hydraulic containment will be required. Finally, the review team recognizes that it is necessary to initiate a more comprehensive analysis of sitewide remediation needs to create links between action taken for the Northwest plume and action taken for other contamination sites at PGPD.

  19. NOAA Climate Data Record (CDR) of AVHRR Polar Pathfinder (APP) Cryosphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) contains the AVHRR Polar Pathfinder (APP) product. APP is a fundamental CDR comprised of calibrated and navigated AVHRR channel...

  20. Dose Modeling Evaluations and Technical Support Document For the Authorized Limits Request for the DOE-Owned Property Outside the Limited Area, Paducah Gaseous Diffusion Plant Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    Boerner, A. J. [Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States). Independent Environmental Assessment and Verification Program; Maldonado, D. G. [Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States). Independent Environmental Assessment and Verification Program; Hansen, Tom [Ameriphysics, LLC (United States)

    2012-09-01

    Environmental assessments and remediation activities are being conducted by the U.S. Department of Energy (DOE) at the Paducah Gaseous Diffusion Plant (PGDP), Paducah, Kentucky. The Oak Ridge Institute for Science and Education (ORISE), a DOE prime contractor, was contracted by the DOE Portsmouth/Paducah Project Office (DOE-PPPO) to conduct radiation dose modeling analyses and derive single radionuclide soil guidelines (soil guidelines) in support of the derivation of Authorized Limits (ALs) for 'DOE-Owned Property Outside the Limited Area' ('Property') at the PGDP. The ORISE evaluation specifically included the area identified by DOE restricted area postings (public use access restrictions) and areas licensed by DOE to the West Kentucky Wildlife Management Area (WKWMA). The licensed areas are available without restriction to the general public for a variety of (primarily) recreational uses. Relevant receptors impacting current and reasonably anticipated future use activities were evaluated. In support of soil guideline derivation, a Conceptual Site Model (CSM) was developed. The CSM listed radiation and contamination sources, release mechanisms, transport media, representative exposure pathways from residual radioactivity, and a total of three receptors (under present and future use scenarios). Plausible receptors included a Resident Farmer, Recreational User, and Wildlife Worker. single radionuclide soil guidelines (outputs specified by the software modeling code) were generated for three receptors and thirteen targeted radionuclides. These soil guidelines were based on satisfying the project dose constraints. For comparison, soil guidelines applicable to the basic radiation public dose limit of 100 mrem/yr were generated. Single radionuclide soil guidelines from the most limiting (restrictive) receptor based on a target dose constraint of 25 mrem/yr were then rounded and identified as the derived soil guidelines. An additional evaluation using the derived soil

  1. Dose Modeling Evaluations and Technical Support Document For the Authorized Limits Request for the DOE-Owned Property Outside the Limited Area, Paducah Gaseous Diffusion Plant Paducah, Kentucky

    International Nuclear Information System (INIS)

    Boerner, A. J.

    2012-01-01

    Environmental assessments and remediation activities are being conducted by the U.S. Department of Energy (DOE) at the Paducah Gaseous Diffusion Plant (PGDP), Paducah, Kentucky. The Oak Ridge Institute for Science and Education (ORISE), a DOE prime contractor, was contracted by the DOE Portsmouth/Paducah Project Office (DOE-PPPO) to conduct radiation dose modeling analyses and derive single radionuclide soil guidelines (soil guidelines) in support of the derivation of Authorized Limits (ALs) for 'DOE-Owned Property Outside the Limited Area' ('Property') at the PGDP. The ORISE evaluation specifically included the area identified by DOE restricted area postings (public use access restrictions) and areas licensed by DOE to the West Kentucky Wildlife Management Area (WKWMA). The licensed areas are available without restriction to the general public for a variety of (primarily) recreational uses. Relevant receptors impacting current and reasonably anticipated future use activities were evaluated. In support of soil guideline derivation, a Conceptual Site Model (CSM) was developed. The CSM listed radiation and contamination sources, release mechanisms, transport media, representative exposure pathways from residual radioactivity, and a total of three receptors (under present and future use scenarios). Plausible receptors included a Resident Farmer, Recreational User, and Wildlife Worker. single radionuclide soil guidelines (outputs specified by the software modeling code) were generated for three receptors and thirteen targeted radionuclides. These soil guidelines were based on satisfying the project dose constraints. For comparison, soil guidelines applicable to the basic radiation public dose limit of 100 mrem/yr were generated. Single radionuclide soil guidelines from the most limiting (restrictive) receptor based on a target dose constraint of 25 mrem/yr were then rounded and identified as the derived soil guidelines. An additional evaluation using the derived soil

  2. PGDP [Paducah Gaseous Diffusion Plant]-UF6 handling, sampling, analysis and associated QC/QA and safety related procedures

    International Nuclear Information System (INIS)

    Harris, R.L.

    1987-01-01

    This document is a compilation of Paducah Gaseous Diffusion Plant procedures on UF 6 handling, sampling, and analysis, along with associated QC/QA and safety related procedures. It was assembled for transmission by the US Department of Energy to the Korean Advanced Energy Institute as a part of the US-Korea technical exchange program

  3. Draft Environmental Impact Statement for Construction and Operation of a Depleted Uranium Hexafluoride Conversion Facility at the Paducah, Kentucky, Site

    International Nuclear Information System (INIS)

    2003-01-01

    This document is a site-specific environmental impact statement (EIS) for construction and operation of a proposed depleted uranium hexafluoride (DUF 6 ) conversion facility at the U.S. Department of Energy (DOE) Paducah site in northwestern Kentucky (Figure S-1). The proposed facility would convert the DUF 6 stored at Paducah to a more stable chemical form suitable for use or disposal. In a Notice of Intent (NOI) published in the ''Federal Register'' (FR) on September 18, 2001 (''Federal Register'', Volume 66, page 48123 [66 FR 48123]), DOE announced its intention to prepare a single EIS for a proposal to construct, operate, maintain, and decontaminate and decommission two DUF 6 conversion facilities at Portsmouth, Ohio, and Paducah, Kentucky, in accordance with the National Environmental Policy Act of 1969 (NEPA) (''United States Code'', Title 42, Section 4321 et seq. [42 USC 4321 et seq.]) and DOE's NEPA implementing procedures (''Code of Federal Regulations'', Title 10, Part 1021 [10 CFR Part 1021]). Subsequent to award of a contract to Uranium Disposition Services, LLC (hereafter referred to as UDS), Oak Ridge, Tennessee, on August 29, 2002, for design, construction, and operation of DUF 6 conversion facilities at Portsmouth and Paducah, DOE reevaluated its approach to the NEPA process and decided to prepare separate site-specific EISs. This change was announced in a ''Federal Register'' Notice of Change in NEPA Compliance Approach published on April 28, 2003 (68 FR 22368); the Notice is included as Attachment B to Appendix C of this EIS. This EIS addresses the potential environmental impacts from the construction, operation, maintenance, and decontamination and decommissioning (DandD) of the proposed conversion facility at three alternative locations within the Paducah site; from the transportation of depleted uranium conversion products to a disposal facility; and from the transportation, sale, use, or disposal of the fluoride-containing conversion products

  4. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1990 to November 1992

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A. [ed.

    1994-03-01

    On September 23, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Lab (ORNL) added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in identifying those effluents with the potential for adversely affecting instream fauna, assessing the ecological health of receiving streams, guiding plans for remediation, and protecting human health. In September 1992, a renewed permit was issued which requires toxicity monitoring of continuous and intermittent outfalls on a quarterly basis. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities. This report includes ESD/ORNL activities occurring from December 1990 to November 1992.

  5. An in situ survey of the Paducah Gaseous Diffusion Plant and surrounding area

    International Nuclear Information System (INIS)

    Hoover, R.A.

    1994-02-01

    An in situ survey of the area surrounding the Paducah Gaseous Diffusion Plant was conducted between May 17 and 24, 1990. The survey consisted of in situ measurements and of ground sampling. A High Purity Germanium detector was used for the in situ measurements. The ground samples were taken to the, laboratory at EG ampersand G Energy Measurements, Inc., in Santa Barbara, California, for a radionuclide assay on a laboratory system. Results of the in situ measurements found evidence of naturally occurring radioisotopes, cesium-137 from international fallout, and some evidence of anomalous uranium-238. The soil sampling results show only the presence of naturally occurring radioisotopes, cesium-137, and also anomalous uranium-238

  6. Seismically-induced soil amplification at the DOE Paducah Gaseous Diffusion Plant site

    International Nuclear Information System (INIS)

    Sykora, D.W.; Haynes, M.E.

    1991-01-01

    A site-specific earthquake site response (soil amplification) study is being conducted for the Department of Energy (DOE), Paducah Gaseous Diffusion Plant (PGDP). This study is pursuant to an upgraded Final Safety Analysis Report in accordance with requirements specified by DOE. The seismic hazard at PGDP is dominated by the New Madrid Seismic Zone. Site-specific synthetic earthquake records developed by others were applied independently to four soil columns with heights above baserock of about 325 ft. The results for the 1000-year earthquake event indicate that the site period is between 1.0 and 1.5 sec. Incident shear waves are amplified at periods of motion greater than 0.15 sec. The peak free-field horizontal acceleration, occurring at very low periods, is 0.28 g. 13 refs., 13 figs

  7. Seismically-induced soil amplification at the DOE Paducah Gaseous Diffusion Plant Site

    International Nuclear Information System (INIS)

    Sykora, D.W.; Hynes, M.E.; Brock, W.R.; Hunt, R.J.; Shaffer, K.E.

    1991-01-01

    A site-specific earthquake site response (soil amplification) study is being conducted for the Department of Energy (DOE), Paducah Gaseous Diffusion Plant (PGDP). This study is pursuant to an upgraded Final Safety Analysis Report in accordance with requirements specified by DOE. The seismic hazard at PGDP is dominated by the New Madrid Seismic Zone. Site-specific synthetic earthquake records developed by others were applied independently to four soil columns with heights above baserock of about 325 ft. The results for the 1000-year earthquake event indicate that the site period is between 1.0 and 1.5 sec. Incident shear waves are strongly amplified at periods of motion greater than 0.3 sec. The peak free-field horizontal acceleration, occurring at very low periods, is 0.28 g

  8. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant December 1990 to November 1992

    International Nuclear Information System (INIS)

    Kszos, L.A.

    1994-03-01

    On September 23, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Lab (ORNL) added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in identifying those effluents with the potential for adversely affecting instream fauna, assessing the ecological health of receiving streams, guiding plans for remediation, and protecting human health. In September 1992, a renewed permit was issued which requires toxicity monitoring of continuous and intermittent outfalls on a quarterly basis. The BMP for PGDP consists of three major tasks: (1) effluent and ambient toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities. This report includes ESD/ORNL activities occurring from December 1990 to November 1992

  9. Safety analysis report on the ''Paducah Tiger'' overpack for 10-ton cylinder of uranium hexafluoride

    International Nuclear Information System (INIS)

    Stitt, D.H.

    1978-01-01

    A summary of analysis performed to assess the puncture resistance of the Paducah Tiger under a particularly severe (worst case) orientation of the external puncture pin is presented. The six-inch diameter cylindrical puncture pin has been oriented to place its impact location immediately opposite the valve body mounted to the dished head of the uranium hexafluoride cylinder. The valve body is assumed to have a one-inch clearance relative to the inner wall of the overpack. Analysis indicates that significant residual kinetic energy remains in the system at the instant of overpack inner wall contact with the valve body. Thus, there is strong evidence suggesting that the valve body can be damaged, or sheared from the dished head of the UF 6 , under the assumed worst case impact orientation

  10. Report on the Biological Monitoring Program at Paducah Gaseous Diffusion Plant December 1992--December 1993

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.; Hinzman, R.L.; Peterson, M.J.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1995-06-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). The goals of BMP are to demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, characterize potential health and environmental impacts, document the effects of pollution abatement facilities on stream biota, and recommend any program improvements that would increase effluent treatability. The BMP for PGDP consists of three major tasks: effluent and ambient toxicity monitoring, bioaccumulation studies, and ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report includes ESD activities occurring from December 1992 to December 1993, although activities conducted outside this time period are included as appropriate.

  11. CLICdet: The post-CDR CLIC detector model

    CERN Document Server

    Alipour Tehrani, Niloufar; Cure, Benoit; Dannheim, Dominik; Duarte Ramos, Fernando; Elsener, Konrad; Gaddi, Andrea; Gerwig, Hubert; Green, Steven; Grefe, Christian; Hynds, Daniel; Klempt, Wolfgang; Linssen, Lucie; Nikiforou, Nikiforos; Nurnberg, Andreas Matthias; Marshall, John Stuart; Petric, Marko; Redford, Sophie; Roloff, Philipp Gerhard; Sailer, Andre; Sefkow, Felix; Sicking, Eva; Siegrist, Nicolas; Simon, Frank Richard; Simoniello, Rosa; Spannagel, Simon; Sroka, Szymon Krzysztof; Strom, Lars Rickard; Weber, Matthias Artur

    2017-01-01

    A new model for the CLIC detector has been defined based on lessons learnt while working with the CDR detector models and after a series of simulation studies. The new model, dubbed "CLICdet", also incorporates the experience from various R&D activities linked to a future experiment at CLIC. This note describes the studies and thoughts leading to the new detector model, and gives details on all of its sub-detector systems.

  12. MJZ VOL 37 NO 2.CDR

    African Journals Online (AJOL)

    MJZ

    Recommendations for the Use of Antiretroviral Drugs for Treating Pregnant ... than 350 cells/mm , regardless of their clinical stage; includes ... This article reviews these new ... No. 2 (2010). Key words: Guidelines, HIV, prevention of mother to.

  13. Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells.

    Science.gov (United States)

    Yang, Xue; Xiong, Qian; Wu, Ying; Li, Siting; Ge, Feng

    2017-10-06

    Circular RNAs (circRNAs), a class of widespread endogenous RNAs, play crucial roles in diverse biological processes and are potential biomarkers in diverse human diseases and cancers. Cerebellar-degeneration-related protein 1 antisense RNA (CDR1as), an oncogenic circRNA, is involved in human tumorigenesis and is dysregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying CDR1as functions in HCC remain unclear. Here we explored the functions of CDR1as and searched for CDR1as-regulated proteins in HCC cells. A quantitative proteomics strategy was employed to globally identify CDR1as-regulated proteins in HCC cells. In total, we identified 330 differentially expressed proteins (DEPs) upon enhanced CDR1as expression in HepG2 cells, indicating that they could be proteins regulated by CDR1as. Bioinformatic analysis revealed that many DEPs were involved in cell proliferation and the cell cycle. Further functional studies of epidermal growth factor receptor (EGFR) found that CDR1as exerts its effects on cell proliferation at least in part through the regulation of EGFR expression. We further confirmed that CDR1as could inhibit the expression of microRNA-7 (miR-7). EGFR is a validated target of miR-7; therefore, CDR1as may exert its function by regulating EGFR expression via targeting miR-7 in HCC cells. Taken together, we revealed novel functions and underlying mechanisms of CDR1as in HCC cells. This study serves as the first proteome-wide analysis of a circRNA-regulated protein in cells and provides a reliable and highly efficient method for globally identifying circRNA-regulated proteins.

  14. JMBR VOLUME 14 Number 2.cdr

    African Journals Online (AJOL)

    FINEPRINT

    JMBR: A Peer-review Journal of Biomedical Sciences pp 63-72. December 2015, Vol. 14 No. 2. ABSTRACT. Combination therapy or polytherapy is the use of more than one antibacterial agent in the treatment of a single infection. In this study, rifampicin that was mainly used in the treatment of mycobacterial infections has ...

  15. JUNE 2010.for Ogidi (final).cdr

    African Journals Online (AJOL)

    User

    clinical audit, intra-partum care, birth attendants, health facilities, quality ... of the baby at birth. Names were excluded from extracted information in order to ensure confidentiality of individual parturients and health care providers, which a study of this nature required. ... records reviewed was 23.4 ± 3.3 years (Confidence.

  16. NOAA Climate Data Record (CDR) of Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN-CDR), Version 1 Revision 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — PERSIANN Precipitation Climate Data Record (PERSIANN-CDR) is a daily quasi-global precipitation product for the period of 1982 to 2011. The data covers from 60...

  17. The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans.

    Science.gov (United States)

    Shao, Jing; Zhang, MengXiang; Wang, TianMing; Li, Yue; Wang, ChangZhong

    2016-01-01

    Fungal infections caused by fluconazole-resistant Candida albicans are an intractable clinical problem, calling for new efficient antifungal drugs. Kaempferol, an active flavonoid, has been considered a potential candidate against Candida species. This work investigates the resistance reversion of kaempferol in fluconazole-resistant C. albicans and the underlying mechanism. The antifungal activities of fluconazole and/or kaempferol were assessed by a series of standard procedures including broth microdilution method, checkerboard assay and time-kill (T-K) test in nine clinical strains as well as a standard reference isolate of C. albicans. Subsequently, the morphological changes, the efflux of rhodamine 6G, and the expressions of CDR 1, CDR 2, and MDR 1 were analysed by scanning electron microscope (SEM), inverted fluorescence microscope and quantitative reverse transcription polymerase chain reaction (qRT-PCR) in C. albicans z2003. For all the tested C. albicans strains, the minimum inhibitory concentrations (MICs) of fluconazole and kaempferol ranged 0.25-32 and 128-256 μg/mL with a range of fractional inhibitory concentration index of 0.257-0.531. In C. albicans z2003, the expression of both CDR 1 and CDR 2 were decreased after exposure to kaempferol alone with negligible rhodamine 6G accumulation, while the expression of CDR 1, CDR 2 and MDR 1 were all decreased when fluconazole and kaempferol were used concomitantly with notable fluorescence of rhodamine 6G observed. Kaempferol-induced reversion in fluconazole-resistant C. albicans might be likely due to the suppression of the expression of CDR1, CDR2 and MDR1.

  18. A Technical Assessment Of The Current Water Policy Boundary At U.S. Department Of Energy, Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    None

    2012-01-01

    In 1988, groundwater contaminated with trichloroethene (TCE) and technetium-99 (Tc-99) was identified in samples collected from residential water wells withdrawing groundwater from the Regional Gravel Aquifer (RGA) north of the Paducah Gaseous Diffusion Plant (PGDP) facility. In response, the U.S. Department of Energy (DOE) provided temporary drinking water supplies to approximately 100 potentially affected residents by initially supplying bottled water, water tanks, and water-treatment systems, and then by extending municipal water lines, all at no cost, to those persons whose wells could be affected by contaminated groundwater. The Water Policy boundary was established in 1993. In the Policy, DOE agreed to pay the reasonable monthly cost of water for homes and businesses and, in exchange, many of the land owners signed license agreements committing to cease using the groundwater via rural water wells. In 2012, DOE requested that Oak Ridge Associated Universities (ORAU), managing contractor of Oak Ridge Institute for Science and Education (ORISE), provide an independent assessment of the quality and quantity of the existing groundwater monitoring data and determine if there is sufficient information to support a modification to the boundary of the current Water Policy. As a result of the assessment, ORAU concludes that sufficient groundwater monitoring data exists to determine that a shrinkage and/or shift of the plume(s) responsible for the initial development of this policy has occurred. Specifically, there is compelling evidence that the TCE plume is undergoing shrinkage due to natural attenuation and associated degradation. The plume shrinkage (and migration) has also been augmented in local areas where large volumes of groundwater were recovered by pump-and treat remedial systems along the eastern and western boundaries of the Northwest Plume, and in other areas where pump-and-treat systems have been deployed by DOE to remove source contaminants. The

  19. Task analysis methods applicable to control room design review (CDR)

    International Nuclear Information System (INIS)

    Moray, N.P.; Senders, J.W.; Rhodes, W.

    1985-06-01

    This report presents the results of a research study conducted in support of the human factors engineering program of the Atomic Energy Control Board in Canada. It contains five products which may be used by the Atomic Enegy Control Board in relation to Task Analysis of jobs in CANDU nuclear power plants: 1. a detailed method for preparing for a task analysis; 2. a Task Data Form for recording task analysis data; 3. a detailed method for carrying out task analyses; 4. a guide to assessing alternative methods for performing task analyses, if such are proposed by utilities or consultants; and 5. an annotated bibliography on task analysis. In addition, a short explanation of the origins, nature and uses of task analysis is provided, with some examples of its cost effectiveness. 35 refs

  20. Report on the Watershed Monitoring Program at the Paducah Site January-December 1998

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.; Peterson, M.J.; Ryon, M.G.; Southworth, G.R.

    1999-03-01

    Watershed Monitoring of Big Bayou and Little Bayou creeks has been conducted since 1987. The monitoring was conducted by the University of Kentucky between 1987 and 1991 and by staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) from 1991 to present. The goals of monitoring are to (1) demonstrate that the effluent limitations established for DOE protect and maintain the use of Little Bayour and Big Bayou creeks for frowth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, and (3) document the effects of pollution abatement facilities on stream biota. The watershed (biological) monitoring discussed in this report was conducted under DOE Order 5400.1, General Environmental Protection Program. Future monitoring will be conducted as required by the Kentucky Pollutant Discharge Elimination System (KPDES) permit issued to the Department of Energy (DOE) in March 1998. A draft Watershed Monitoring Program plan was approved by the Kentucky Division of Water and will be finalized in 1999. The DOE permit also requires toxicity monitoring of one continuous outfall and of three intermittent outfalls on a quarterly basis. The Watershed Monitoring Program for the Paducah Site during calendar year 1998 consisted of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of fish communities. This report focuses on ESD activities occurring from january 1998 to December 1998, although activities conducted outside this time period are included as appropriate.

  1. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January--December 1996

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A. [ed.; Konetsky, B.K.; Peterson, M.J.; Petrie, R.B.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1997-06-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous diffusion Plant (PGDP). The PGDP BMP was conducted by the University of Kentucky Between 1987 and 1992 and by staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) from 1991 to present. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, and (3) document the effects of pollution abatement facilities on stream. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report focuses on ESD activities occurring from January 1996 to December 1996, although activities conducted outside this time period are included as appropriate.

  2. LANMAS alpha configured for Sandia National Laboratories and Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Woychick, M.R.; Bracey, J.T.; Kern, E.A.; Alvarado, A.

    1993-07-01

    Los Alamos National Laboratory and the Westinghouse Hanford Company have been working jointly for the past 2 years to develop LANMAS (Local Area Network Material Accountability System), the next generation of a US Department of Energy nuclear material accountability system. LANMAS is being designed to reflect the broad-based needs of the US Department of Energy's Material Control ampersand Accountability and Nuclear Materials Management communities, and its developers believe that significant cost savings can be achieved by implementing LANMAS complex-wide, where feasible. LANMAS is being designed so that it is transportable to appropriate US Department of Energy sites. To accomplish this, LANMAS will be configurable to local site work culture. Many US Department of Energy sites are interested in the LANMAS project, and several have participated in its development; some have committed resources. The original LANMAS project team included representatives from the Hanford Site and Los Alamos. As of June 1993, the following sites have also supported the project: Sandia National Laboratory Albuquerque; Sandia National Laboratory Livermore; Paducah Gaseous Diffusion Plant; Lawrence Livermore National Laboratory; Bettis Atomic Power Laboratory; and Knolls Atomic Power Laboratory. In addition, LANMAS is being targeted as a candidate for the US Department of Energy Complex 21, a project designed to restructure the nation's nuclear weapons complex

  3. Martin Marietta Paducah Gaseous Diffusion Plant comprehensive earthquake emergency management program

    International Nuclear Information System (INIS)

    1990-01-01

    Recognizing the value of a proactive, integrated approach to earthquake preparedness planning, Martin Marietta Energy Systems, Inc. initiated a contract in June 1989 with Murray State University, Murray, Kentucky, to develop a comprehensive earthquake management program for their Gaseous Diffusion Plant in Paducah, Kentucky. The overall purpose of the program is to mitigate the loss of life and property in the event of a major destructive earthquake. The program includes four distinct (yet integrated) components: an emergency management plan, with emphasis on the catastrophic earthquake; an Emergency Operations Center Duty Roster Manual; an Integrated Automated Emergency Management Information System (IAEMIS); and a series of five training program modules. The PLAN itself is comprised of four separate volumes: Volume I -- Chapters 1--3; Volume II -- Chapters 4--6, Volume III -- Chapter 7, and Volume IV -- 23 Appendices. The EOC Manual (which includes 15 mutual aid agreements) is designated as Chapter 7 in the PLAN and is a ''stand alone'' document numbered as Volume III. This document, Volume I, provides an introduction, summary and recommendations, and the emergency operations center direction and control

  4. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January-December 1997

    International Nuclear Information System (INIS)

    Kszos, L.A.; Peterson, M.J.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1998-03-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). A plan for the biological monitoring of the receiving streams was implemented in 1987 and consisted of ecological surveys, toxicity monitoring of effluents and receiving streams, evaluation of bioaccumulation of trace contaminants in biota, and supplemental chemical characterization of effluents. Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in (1) identifying those effluents with the potential for adversely affecting instream fauna, (2) assessing the ecological health of receiving streams, and (3) guiding plans for remediation and protecting human health. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of benthic macroinvertebrate communities and fish. With the exception of the benthic macroinvertebrate community surveys, this report focuses on activities from January to December 1997

  5. Operating limit study for the proposed solid waste landfill at Paducah Gaseous Diffusion Plant

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D.W.; Wang, J.C.; Kocher, D.C.

    1995-06-01

    A proposed solid waste landfill at Paducah Gaseous Diffusion Plant (PGDP) would accept wastes generated during normal operations that are identified as non-radioactive. These wastes may include small amounts of radioactive material from incidental contamination during plant operations. A site-specific analysis of the new solid waste landfill is presented to determine a proposed operating limit that will allow for waste disposal operations to occur such that protection of public health and the environment from the presence of incidentally contaminated waste materials can be assured. Performance objectives for disposal were defined from existing regulatory guidance to establish reasonable dose limits for protection of public health and the environment. Waste concentration limits were determined consistent with these performance objectives for the protection of off-site individuals and inadvertent intruders who might be directly exposed to disposed wastes. Exposures of off-site individuals were estimated using a conservative, site-specific model of the groundwater transport of contamination from the wastes. Direct intrusion was analyzed using an agricultural homesteader scenario. The most limiting concentrations from direct intrusion or groundwater transport were used to establish the concentration limits for radionuclides likely to be present in PGDP wastes.

  6. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January--December 1997

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.; Peterson, M.J.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1998-03-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous Diffusion Plant (PGDP). A plan for the biological monitoring of the receiving streams was implemented in 1987 and consisted of ecological surveys, toxicity monitoring of effluents and receiving streams, evaluation of bioaccumulation of trace contaminants in biota, and supplemental chemical characterization of effluents. Beginning in fall 1991, the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory added data collection and report preparation to its responsibilities for the PGDP BMP. The BMP has been continued because it has proven to be extremely valuable in (1) identifying those effluents with the potential for adversely affecting instream fauna, (2) assessing the ecological health of receiving streams, and (3) guiding plans for remediation and protecting human health. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of benthic macroinvertebrate communities and fish. With the exception of the benthic macroinvertebrate community surveys, this report focuses on activities from January to December 1997.

  7. Strong motion modeling at the Paducah Diffusion Facility for a large New Madrid earthquake

    International Nuclear Information System (INIS)

    Herrmann, R.B.

    1991-01-01

    The Paducah Diffusion Facility is within 80 kilometers of the location of the very large New Madrid earthquakes which occurred during the winter of 1811-1812. Because of their size, seismic moment of 2.0 x 10 27 dyne-cm or moment magnitude M w = 7.5, the possible recurrence of these earthquakes is a major element in the assessment of seismic hazard at the facility. Probabilistic hazard analysis can provide uniform hazard response spectra estimates for structure evaluation, but a deterministic modeling of a such a large earthquake can provide strong constraints on the expected duration of motion. The large earthquake is modeled by specifying the earthquake fault and its orientation with respect to the site, and by specifying the rupture process. Synthetic time histories, based on forward modeling of the wavefield, from each subelement are combined to yield a three component time history at the site. Various simulations are performed to sufficiently exercise possible spatial and temporal distributions of energy release on the fault. Preliminary results demonstrate the sensitivity of the method to various assumptions, and also indicate strongly that the total duration of ground motion at the site is controlled primarily by the length of the rupture process on the fault

  8. Determination of operating limits for radionuclides for a proposed landfill at Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Wang, J.C.; Lee, D.W.; Ketelle, R.H.; Lee, R.R.; Kocher, D.C.

    1994-01-01

    The operating limits for radionuclides in sanitary and industrial wastes were determined for a proposed landfill at the Paducah Gaseous Diffusion Plant (PGDP), Kentucky. These limits, which may be very small but nonzero, are not mandated by law or regulation but are needed for rational operation. The approach was based on analyses of the potential contamination of groundwater at the plant boundary and the potential exposure to radioactivity of an intruder at the landfill after closure. The groundwater analysis includes (1) a source model describing the disposal of waste and the release of radionuclides from waste to the groundwater, (2) site-specific groundwater flow and contaminant transport calculations, and (3) calculations of operating limits from the dose limit and conversion factors. The intruder analysis includes pathways through ingestion of contaminated vegetables and soil, external exposure to contaminated soil, and inhalation of suspended activity from contaminated soil particles. In both analyses, a limit on annual effective dose equivalent of 4 mrem (0.04 mSv) was adopted. The intended application of the results is to refine the radiological monitoring standards employed by the PGDP Health Physics personnel to determine what constitutes radioactive wastes, with concurrence of the Commonwealth of Kentucky

  9. Operating limit study for the proposed solid waste landfill at Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Lee, D.W.; Wang, J.C.; Kocher, D.C.

    1995-06-01

    A proposed solid waste landfill at Paducah Gaseous Diffusion Plant (PGDP) would accept wastes generated during normal operations that are identified as non-radioactive. These wastes may include small amounts of radioactive material from incidental contamination during plant operations. A site-specific analysis of the new solid waste landfill is presented to determine a proposed operating limit that will allow for waste disposal operations to occur such that protection of public health and the environment from the presence of incidentally contaminated waste materials can be assured. Performance objectives for disposal were defined from existing regulatory guidance to establish reasonable dose limits for protection of public health and the environment. Waste concentration limits were determined consistent with these performance objectives for the protection of off-site individuals and inadvertent intruders who might be directly exposed to disposed wastes. Exposures of off-site individuals were estimated using a conservative, site-specific model of the groundwater transport of contamination from the wastes. Direct intrusion was analyzed using an agricultural homesteader scenario. The most limiting concentrations from direct intrusion or groundwater transport were used to establish the concentration limits for radionuclides likely to be present in PGDP wastes

  10. Martin Marietta Paducah Gaseous Diffusion Plant comprehensive earthquake emergency management program

    International Nuclear Information System (INIS)

    1990-01-01

    Recognizing the value of a proactive, integrated approach to earthquake preparedness planning, Martin Marietta Energy Systems, Inc. initiated a contract in June 1989 with Murray State University, Murray, Kentucky, to develop a comprehensive earthquake management program for their Gaseous Diffusion Plant in Paducah, Kentucky (PGDP -- Subcontract No. 19P-JV649V). The overall purpose of the program is to mitigate the loss of life and property in the event of a major destructive earthquake. The program includes four distinct (yet integrated) components: an emergency management plan, with emphasis on the catastrophic earthquake; an Emergency Operations Center Duty Roster Manual; an Integrated Automated Emergency Management Information System (IAEMIS); and a series of five training program modules. The PLAN itself is comprised of four separate volumes: Volume I -- Chapters 1--3; Volume II -- Chapters 4--6, Volume III -- Chapter 7, and Volume IV -- 23 Appendices. The EOC Manual (which includes 15 mutual aid agreements) is designated as Chapter 7 in the PLAN and is a ''stand alone'' document numbered as Volume III. This document, Volume II, discusses methodology, engineering and environmental analyses, and operational procedures

  11. Martin Marietta Paducah Gaseous Diffusion Plant comprehensive earthquake emergency management program

    International Nuclear Information System (INIS)

    1990-01-01

    Recognizing the value of a proactive, integrated approach to earthquake preparedness planning, Martin Marietta Energy Systems, Inc, initiated a contract in June 1989 with Murray State University, Murray, Kentucky, to develop a comprehensive earthquake management program for their Gaseous Diffusion Plant in Paducah, Kentucky (PGDP--Subcontract No. 19P-JV649V). The overall purpose of the program is to mitigate the loss of life and property in the event of a major destructive earthquake. The program includes four distinct (yet integrated) components: (1) an emergency management plan, with emphasis on the catas trophic earthquake, (2) an Emergency Operations Center Duty Roster Manual, (3) an Integrated Automated Emergency Management Information System (IAEMIS), and (4) a series of five training program modules. The PLAN itself is comprised of four separate volumes: Volume I--Chapters 1--3; Volume II--Chapters 4--6, Volume III--Chapter 7, and Volume IV--23 Appendices. The EOC Manual (which includes 15 mutual aid agreements) is designated as Chapter 7 in the PLAN and is a ''stand alone'' document numbered as Volume III. This document, Volume IV contains the appendices to this report

  12. Martin Marietta Paducah Gaseous Diffusion Plant comprehensive earthquake emergency management program

    International Nuclear Information System (INIS)

    1990-01-01

    Recognizing the value of a proactive, integrated approach to earthquake preparedness planning, Martin Marietta Energy Systems, Inc. initiated a contract in June 1989 with Murray State University, Murray, Kentucky, to develop a comprehensive earthquake management program for their Gaseous Diffusion Plant in Paducah, Kentucky (PGDP -- Subcontract No. 19P-JV649V). The overall purpose of the program is to mitigate the loss of life and property in the event of a major destructive earthquake. The program includes four distinct (yet integrated) components: (1) an emergency management plan with emphasis on the catas trophic earthquake; (2) an Emergency Operations Center Duty Roster Manual; (3) an Integrated Automated Emergency Management Information System (IAEMIS); and (4) a series of five training program modules. The PLAN itself is comprised of four separate volumes: Volume I -- Chapters 1--3; Volume II -- Chapters 4--6; Volume III -- Chapter 7; and Volume IV -- 23 Appendices. The EOC Manual (which includes 15 mutual aid agreements) is designated as Chapter 7 in the PLAN and is this document numbered as Volume III

  13. Assessment and interpretation of cross- and down-hole seismograms at the Paducah Gaseous Diffusion Plant

    Energy Technology Data Exchange (ETDEWEB)

    Staub, W.P.; Wang, J.C. (Oak Ridge National Lab., TN (United States)); Selfridge, R.J. (Automated Sciences Group, (United States))

    1991-09-01

    This paper is an assessment and interpretation of cross-and down-hole seismograms recorded at four sites in the vicinity of the Paducah Gaseous Diffusion Plant (PGDP). Arrival times of shear (S-) and compressional (P-) waves are recorded on these seismograms in milliseconds. Together with known distances between energy sources and seismometers lowered into boreholes, these arrival times are used to calculate S- and P-wave velocities in unconsolidated soils and sediments that overlie bedrock approximately 320 ft beneath PGDP. The soil columns are modified after an earlier draft by ERC Environmental and Energy Services Company (ERCE), 1990. In addition to S- and P- wave velocity estimates from this paper, the soil columns contain ERCE's lithologic and other geotechnical data for unconsolidated soils and sediments from the surface to bedrock. Soil columns for Sites 1 through 4 and a site location map are in Plates 1 through 5 of Appendix 6. The velocities in the four columns are input parameters for the SHAKE computer program, a nationally recognized computer model that simulates ground response of unconsolidated materials to earthquake generated seismic waves. The results of the SHAKE simulation are combined with predicted ground responses on rock foundations (caused by a given design earthquake) to predict ground responses of facilities with foundations placed on unconsolidated materials. 3 refs.

  14. Report on the biological monitoring program at Paducah Gaseous Diffusion Plant, January - December 1996

    International Nuclear Information System (INIS)

    Kszos, L.A.; Konetsky, B.K.; Peterson, M.J.; Petrie, R.B.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.

    1997-06-01

    On September 24, 1987, the Commonwealth of Kentucky Natural Resources and Environmental Protection Cabinet issued an Agreed Order that required the development of a Biological Monitoring Program (BMP) for the Paducah Gaseous diffusion Plant (PGDP). The PGDP BMP was conducted by the University of Kentucky Between 1987 and 1992 and by staff of the Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) from 1991 to present. The goals of BMP are to (1) demonstrate that the effluent limitations established for PGDP protect and maintain the use of Little Bayou and Big Bayou creeks for growth and propagation of fish and other aquatic life, (2) characterize potential environmental impacts, and (3) document the effects of pollution abatement facilities on stream. The BMP for PGDP consists of three major tasks: (1) effluent toxicity monitoring, (2) bioaccumulation studies, and (3) ecological surveys of stream communities (i.e., benthic macroinvertebrates and fish). This report focuses on ESD activities occurring from January 1996 to December 1996, although activities conducted outside this time period are included as appropriate

  15. Cooling tower drift studies at the Paducah, Kentucky Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Taylor, F.G.; Hanna, S.R.; Parr, P.D.

    1979-01-01

    The transfer and fate of chromium from cooling tower drift to terrestrial ecosystems were quantified at the Department of Energy's uranium enrichment facility at Paducah, Kentucky. Chromium concentrations in plant materials (fescue grass) decreased with increasing distance from the cooing tower, ranging from 251 +- 19 ppM at 15 meters to 0.52 +- 0.07 ppM at 1500 meters. The site of drift contamination, size characteristics, and elemental content of drift particles were determined using a scanning electron microscope with energy dispersive x-ray analysis capabilities. Results indicate that elemental content in drift water (mineral residue) may not be equivalent to the content in the recirculating cooling water of the tower. This hypothesis is contrary to basic assumptions in calculating drift emissions. A laboratory study simulating throughfall from 1 to 6 inches of rain suggested that there are more exchange sites associated with litter than live foliage. Leachate from each one inch throughfall simulant removed 3% of the drift mass from litter compared to 7 to 9% from live foliage. Results suggest that differences in retention are related to chemical properties of the drift rather than physical lodging of the particle residue. To determine the potential for movement of drift-derived chromium to surface streams, soil--water samplers (wells) were placed along a distance gradient to Little Bayou Creek. Samples from two depths following rainstorms revealed the absence of vertical or horizontal movement with maximum concentrations of 0.13 ppb at 50 meters from the tower. Preliminary model estimates of drift deposition are compared to depositionmeasurements. Isopleths of the predicted deposition are useful to identify areas of maximum drift transport in the environs of the gaseous diffusion plant

  16. NOAA Climate Data Record (CDR) of Ocean Near Surface Atmospheric Properties, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Ocean Surface Bundle (OSB) Climate Data Record (CDR) consist of three parts: sea surface temperature; near-surface wind speed, air temperature, and specific...

  17. NOAA Climate Data Record (CDR) of Ocean Heat Fluxes, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Ocean Surface Bundle (OSB) Climate Data Record (CDR) consist of three parts: sea surface temperature; near-surface wind speed, air temperature, and specific...

  18. NOAA Climate Data Record (CDR) of Sea Surface Temperature - WHOI, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Ocean Surface Bundle (OSB) Climate Data Record (CDR) consist of three parts: sea surface temperature, near-surface atmospheric properties, and heat fluxes....

  19. NOAA Climate Data Record (CDR) of Total Solar Irradiance (TSI), NRLTSI Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) contains total solar irradiance (TSI) as a function of time created with the Naval Research Laboratory model for spectral and total...

  20. NOAA Climate Data Record (CDR) of Solar Spectral Irradiance (SSI), NRLSSI Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) contains solar spectral irradiance (SSI) as a function of time and wavelength created with the Naval Research Laboratory model for...

  1. NOAA Climate Data Record (CDR) of Atmospheric Layer Temperatures, Version 3.3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Atmospheric Layer Temperature Climate Data Record (CDR) dataset is a monthly analysis of the tropospheric and stratospheric data using temperature sounding...

  2. NOAA Climate Data Record (CDR) of Passive Microwave Sea Ice Concentration, Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Passive Microwave Sea Ice Concentration Climate Data Record (CDR) dataset is generated using daily gridded brightness temperatures from the Defense...

  3. NOAA Climate Data Record (CDR) of AVHRR Polar Pathfinder Extended (APP-X) Cryosphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Climate Data Record (CDR) of the extended AVHRR Polar Pathfinder (APP-x) cryosphere contains 19 geophysical variables over the Arctic and Antarctic for the...

  4. NOAA Climate Data Record (CDR) of Monthly Outgoing Longwave Radiation (OLR), Version 2.2-1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) of monthly mean High Resolution Infrared Radiation Sounder (HIRS) Outgoing Longwave Radiation (OLR) flux at the top of the atmosphere...

  5. NOAA Climate Data Record (CDR) of Daily Outgoing Longwave Radiation (OLR), Version 1.2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Climate Data Record (CDR) contains the daily mean Outgoing Longwave Radiation (OLR) time series in global 1 degree x 1 degree equal-angle gridded maps spanning...

  6. NOAA Climate Data Record (CDR) of Normalized Difference Vegetation Index (NDVI), Version 4

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains gridded daily Normalized Difference Vegetation Index (NDVI) derived from the NOAA Climate Data Record (CDR) of Advanced Very High Resolution...

  7. NOAA Climate Data Record (CDR) of Northern Hemisphere (NH) Snow Cover Extent (SCE), Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) is a record for the Northern Hemisphere (NH) Snow Cover Extent (SCE) spanning from October 4, 1966 to present, updated monthly...

  8. NOAA Fundamental Climate Data Record (CDR) of AMSU-B and MHS Brightness Temperature, Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Climate Data Record (CDR) of Advanced Microwave Sounding Unit-B (AMSU-B) and Microwave Humidity Sounder (MHS) brightness temperature (Tb) in "window...

  9. NOAA Climate Data Record (CDR) of Passive Microwave Sea Ice Concentration, Version 1.0

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset version has been superseded by version 2. This data set provides a Climate Data Record (CDR) of passive microwave sea ice concentration based on the...

  10. Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans

    International Nuclear Information System (INIS)

    Shukla, Suneet; Sauna, Zuben E.; Prasad, Rajendra; Ambudkar, Suresh V.

    2004-01-01

    To find novel drugs for effective antifungal therapy in candidiasis, we examined disulfiram, a drug used for the treatment of alcoholism, for its role as a potential modulator of Candida multidrug transporter Cdr1p. We show that disulfiram inhibits the oligomycin-sensitive ATPase activity of Cdr1p and 2.5 mM dithiothreitol reverses this inhibition. Disulfiram inhibited the binding of photoaffinity analogs of both ATP ([α- 32 P]8-azidoATP; IC 50 = 0.76 μM) and drug-substrates ([ 3 H]azidopine and [ 125 I]iodoarylazidoprazosin; IC 50 ∼ 12 μM) to Cdr1p in a concentration-dependent manner, suggesting that it can interact with both ATP and substrate-binding site(s) of Cdr1p. Furthermore, a non-toxic concentration of disulfiram (1 μM) increased the sensitivity of Cdr1p expressing Saccharomyces cerevisiae cells to antifungal agents (fluconazole, miconazole, nystatin, and cycloheximide). Collectively these results demonstrate that disulfiram reverses Cdr1p-mediated drug resistance by interaction with both ATP and substrate-binding sites of the transporter and may be useful for antifungal therapy

  11. JMBR VOLUME 14 NO 1 - JUNE 2015.cdr- CORRESPONDENCE.cdr

    African Journals Online (AJOL)

    FinePrint

    2015-06-01

    Jun 1, 2015 ... physical functioning, work, productivity and health costs. ... prevalence of neck pain in the study population were 67.9%, 65.9% and ... Male gender (OR=0.325, CI=0.16-0.67), being married (OR=0.308, ... importance of finding out the prevalence ..... population: A systematic critical review of the literature.

  12. Expression of the CDR1 efflux pump in clinical Candida albicans isolates is controlled by a negative regulatory element

    International Nuclear Information System (INIS)

    Gaur, Naseem Akhtar; Manoharlal, Raman; Saini, Preeti; Prasad, Tulika; Mukhopadhyay, Gauranga; Hoefer, Milan; Morschhaeuser, Joachim; Prasad, Rajendra

    2005-01-01

    Resistance to azole antifungal drugs in clinical isolates of the human fungal pathogen Candida albicans is often caused by constitutive overexpression of the CDR1 gene, which encodes a multidrug efflux pump of the ABC transporter superfamily. To understand the relevance of a recently identified negative regulatory element (NRE) in the CDR1 promoter for the control of CDR1 expression in the clinical scenario, we investigated the effect of mutation or deletion of the NRE on CDR1 expression in two matched pairs of azole-sensitive and resistant clinical isolates of C. albicans. Expression of GFP or lacZ reporter genes from the wild type CDR1 promoter was much higher in the azole-resistant C. albicans isolates than in the azole-susceptible isolates, reflecting the known differences in CDR1 expression in these strains. Deletion or mutation of the NRE resulted in enhanced reporter gene expression in azole-sensitive strains, but did not further increase the already high CDR1 promoter activity in the azole-resistant strains. In agreement with these findings, electrophoretic mobility shift assays showed a reduced binding to the NRE of nuclear extracts from the resistant C. albicans isolates as compared with extracts from the sensitive isolates. These results demonstrate that the NRE is involved in maintaining CDR1 expression at basal levels and that this repression is overcome in azole-resistant clinical C. albicans isolates, resulting in constitutive CDR1 overexpression and concomitant drug resistance

  13. Floodplain/wetland assessment of the effects of construction and operation ofa depleted uranium hexafluoride conversion facility at the Paducah, Kentucky,site.

    Energy Technology Data Exchange (ETDEWEB)

    Van Lonkhuyzen, R.

    2005-09-09

    The U.S. Department of Energy (DOE) Depleted Uranium Hexafluoride (DUF{sub 6}) Management Program evaluated alternatives for managing its inventory of DUF{sub 6} and issued the ''Programmatic Environmental Impact Statement for Alternative Strategies for the Long-Term Management and Use of Depleted Uranium Hexafluoride'' (DUF{sub 6} PEIS) in April 1999 (DOE 1999). The DUF{sub 6} inventory is stored in cylinders at three DOE sites: Paducah, Kentucky; Portsmouth, Ohio; and East Tennessee Technology Park (ETTP), near Oak Ridge, Tennessee. In the Record of Decision for the DUF{sub 6} PEIS, DOE stated its decision to promptly convert the DUF{sub 6} inventory to a more stable chemical form. Subsequently, the U.S. Congress passed, and the President signed, the ''2002 Supplemental Appropriations Act for Further Recovery from and Response to Terrorist Attacks on the United States'' (Public Law No. 107-206). This law stipulated in part that, within 30 days of enactment, DOE must award a contract for the design, construction, and operation of a DUF{sub 6} conversion plant at the Department's Paducah, Kentucky, and Portsmouth, Ohio, sites, and for the shipment of DUF{sub 6} cylinders stored at ETTP to the Portsmouth site for conversion. This floodplain/wetland assessment has been prepared by DOE, pursuant to Executive Order 11988 (''Floodplain Management''), Executive Order 11990 (Protection of Wetlands), and DOE regulations for implementing these Executive Orders as set forth in Title 10, Part 1022, of the ''Code of Federal Regulations'' (10 CFR Part 1022 [''Compliance with Floodplain and Wetland Environmental Review Requirements'']), to evaluate potential impacts to floodplains and wetlands from the construction and operation of a conversion facility at the DOE Paducah site. Reconstruction of the bridge crossing Bayou Creek would occur within the Bayou Creek 100-year

  14. Detecting Treatment Group Differences in Alzheimer's Disease Clinical Trials: A Comparison of Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) and the Clinical Dementia Rating - Sum of Boxes (CDR-SB).

    Science.gov (United States)

    Wessels, A M; Dowsett, S A; Sims, J R

    2018-01-01

    The Alzheimer's Disease Assessment Scale's cognitive subscale (ADAS-Cog) has been widely used as an outcome measure in Alzheimer's Disease (AD) clinical trials. In its original form (ADAS-Cog11), the scale has been used successfully in mild-to-moderate AD dementia populations, but its use is more limited in the study of earlier disease (mild cognitive impairment [MCI] or mild dementia due to AD) owing to lack of appropriate sensitivity of some items. With recent focus on earlier treatment, efforts have focused on the development of more sensitive tools, including the Clinical Dementia Rating-Sum of Boxes (CDR-SB), a global assessment tool to evaluate both cognition and function. The ability of the ADAS-Cog and CDR-SB to detect treatment group differences in the clinical trial environment has not been systematically studied. The aim of this analysis was to compare the utility of these tools in detecting treatment group differences, by reviewing study findings identified through advanced searches of clinicaltrials.gov and Ovid, and press releases and scientific presentations. Findings from placebo-controlled studies of ≥ 6m duration and enrolling >100 participants were included; reporting of both the ADAS-Cog and CDR-SB at endpoint was also a requirement. Of the >300 records identified, 34 studies fulfilled the criteria. There were significant placebo versus active drug group differences based on findings from at least one measure for 14 studies. The ADAS-Cog detected treatment differences more frequently than the CDR-SB. Based on these and previously published findings, the ADAS-Cog appears more useful than the CDR-SB in detecting treatment group differences.

  15. Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions

    Directory of Open Access Journals (Sweden)

    Catherine L Townsend

    2016-09-01

    Full Text Available Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain CDR-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 - light chain variable region sequences from IgM-transcribing, newly formed B cells isolated from human bone marrow and peripheral blood. We also used a published human naïve dataset to investigate the CDR-H3 properties of heavy chains paired with kappa and lambda light chains, and probed the Protein Data Bank (PDB to investigate the structural differences between kappa and lambda antibody CDR regions. We found that kappa and lambda light chains have very different CDR physicochemical and structural properties, whereas the heavy chains with which they are paired do not differ significantly. We also observed that the mean CDR3 N nucleotide addition in the kappa, lambda and heavy chain gene rearrangements are correlated within donors, but can differ between donors. This indicates that TdT may work with differing efficiencies between different people, but the same efficiency in the different classes of immunoglobulin chain within one person. We have observed large differences in the physicochemical and structural properties of kappa and lambda light chain CDR regions. This may reflect different roles in the humoral immune response.

  16. Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions.

    Science.gov (United States)

    Townsend, Catherine L; Laffy, Julie M J; Wu, Yu-Chang Bryan; Silva O'Hare, Joselli; Martin, Victoria; Kipling, David; Fraternali, Franca; Dunn-Walters, Deborah K

    2016-01-01

    Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 light chain variable region sequences from IgM-transcribing, newly formed B cells isolated from human bone marrow and peripheral blood. We also used a published human naïve dataset to investigate the CDR-H3 properties of heavy chains paired with kappa and lambda light chains and probed the Protein Data Bank to investigate the structural differences between kappa and lambda antibody CDR regions. We found that kappa and lambda light chains have very different CDR physicochemical and structural properties, whereas the heavy chains with which they are paired do not differ significantly. We also observed that the mean CDR3 N nucleotide addition in the kappa, lambda, and heavy chain gene rearrangements are correlated within donors but can differ between donors. This indicates that terminal deoxynucleotidyl transferase may work with differing efficiencies between different people but the same efficiency in the different classes of immunoglobulin chain within one person. We have observed large differences in the physicochemical and structural properties of kappa and lambda light chain CDR regions. This may reflect different roles in the humoral immune response.

  17. CLIC CDR - physics and detectors: CLIC conceptual design report.

    Energy Technology Data Exchange (ETDEWEB)

    Berger, E.; Demarteau, M.; Repond, J.; Xia, L.; Weerts, H. (High Energy Physics); (Many)

    2012-02-10

    This report forms part of the Conceptual Design Report (CDR) of the Compact LInear Collider (CLIC). The CLIC accelerator complex is described in a separate CDR volume. A third document, to appear later, will assess strategic scenarios for building and operating CLIC in successive center-of-mass energy stages. It is anticipated that CLIC will commence with operation at a few hundred GeV, giving access to precision standard-model physics like Higgs and top-quark physics. Then, depending on the physics landscape, CLIC operation would be staged in a few steps ultimately reaching the maximum 3 TeV center-of-mass energy. Such a scenario would maximize the physics potential of CLIC providing new physics discovery potential over a wide range of energies and the ability to make precision measurements of possible new states previously discovered at the Large Hadron Collider (LHC). The main purpose of this document is to address the physics potential of a future multi-TeV e{sup +}e{sup -} collider based on CLIC technology and to describe the essential features of a detector that are required to deliver the full physics potential of this machine. The experimental conditions at CLIC are significantly more challenging than those at previous electron-positron colliders due to the much higher levels of beam-induced backgrounds and the 0.5 ns bunch-spacing. Consequently, a large part of this report is devoted to understanding the impact of the machine environment on the detector with the aim of demonstrating, with the example of realistic detector concepts, that high precision physics measurements can be made at CLIC. Since the impact of background increases with energy, this document concentrates on the detector requirements and physics measurements at the highest CLIC center-of-mass energy of 3 TeV. One essential output of this report is the clear demonstration that a wide range of high precision physics measurements can be made at CLIC with detectors which are challenging, but

  18. Cdr2p contributes to fluconazole resistance in Candida dubliniensis clinical isolates.

    LENUS (Irish Health Repository)

    2011-05-01

    The development of resistance to azole antifungals used in the treatment of fungal infections can be a serious medical problem. Here, we investigate the molecular mechanisms associated with reduced susceptibility to fluconazole in clinical isolates of Candida dubliniensis , showing evidence of the trailing growth phenomenon. The changes in membrane sterol composition were studied in the presence of subinhibitory fluconazole concentrations. Despite lanosterol and eburicol accumulating as the most prevalent sterols after fluconazole treatment, these ergosterol precursors still support growth of Candida isolates. The overexpression of ABC transporters was demonstrated by immunoblotting employing specific antibodies against Cdr1p and Cdr2p. The presence of a full-length 170 kDa protein Cdr1p was detected in two isolates, while a truncated form of Cdr1p with the molecular mass of 85 kDa was observed in isolate 966\\/3(2). Notably, Cdr2p was detected in this isolate, and the expression of this transporter was modulated by subinhibitory concentrations of fluconazole. These results suggest that C. dubliniensis can display the trailing growth phenomenon, and such isolates express similar molecular mechanisms like that of fluconazole-resistant isolates and can therefore be associated with recurrent infections.

  19. Environmental investigations at the Paducah Gaseous Diffusion Plant and surrounding area, McCracken County, Kentucky. Volume 1 - Executive summary. Final report

    International Nuclear Information System (INIS)

    1994-05-01

    This report details the results of four studies into environmental and cultural resources on and near the Department of Energy's (DOE) Paducah Gaseous Diffusion Plant (PGDP) located in Western Kentucky in McCracken County, approximately 10 miles west of Paducah, KY. The area investigated includes the PGDP facility proper, additional area owned by DOE under use permit to the Western Kentucky Wildlife Management Area (WKWMA), area owned by the Commonwealth of Kentucky that is administered by the WKWMA, area owned by the Tennessee Valley Authority (TVA), the Metropolis Lake State Nature preserve and some privately held land. DOE requested the assistance and support of the US Army Engineer District, Nashville (CEORN) in conducting various environmental investigations of the area. The US Army Engineer Waterways Experiment Station (WES) provided technical support to the CEORN for environmental investigations of (1) wetland resources, (2) threatened or endangered species and habitats, and (3) cultural resources. A floodplain investigation was conducted by CEORN

  20. APPLICATION OF THE LASAGNA(trademark) SOIL REMEDIATION TECHNOLOGY AT THE DOE PADUCAH GASEOUS DIFFUSION PLANT

    International Nuclear Information System (INIS)

    Swift, Barry D.; Tarantino, Joseph J. P. E.

    2003-01-01

    The Paducah Gaseous Diffusion Plant (PGDP), owned by the Department of Energy (DOE), has been enriching uranium since the early 1950s. The enrichment process involves electrical and mechanical components that require periodic cleaning. The primary cleaning agent was trichloroethene (TCE) until the late 1980s. Historical documentation indicates that a mixture of TCE and dry ice were used at PGDP for testing the integrity of steel cylinders, which stored depleted uranium. TCE and dry ice were contained in a below-ground pit and used during the integrity testing. TCE seeped from the pit and contaminated the surrounding soil. The Lasagna(trademark) technology was identified in the Record of Decision (ROD) as the selected alternative for remediation of the cylinder testing site. A public-private consortium formed in 1992 (including DOE, the U.S. Environmental Protection Agency, and the Kentucky Department for Environmental Protection, Monsanto, DuPont, and General Electric) developed the Lasagna(trademark) technology. This innovative technology employs electrokinetics to remediate soil contaminated with organics and is especially suited to sites with low permeability soils. This technology uses direct current to move water through the soil faster and more uniformly than hydraulic methods. Electrokinetics moves contaminants in soil pore water through treatment zones comprised of iron filings, where the contaminants are decomposed to basic chemical compounds such as ethane. After three years of development in the laboratory, the consortium field tested the Lasagna(trademark) process in several phases. CDM installed and operated Phase I, the trial installation and field test of a 150-square-foot area selected for a 120-day run in 1995. Approximately 98 percent of the TCE was removed. CDM then installed and operated the next phase (IIa), a year-long test on a 600-square-foot site. Completed in July 1997, this test removed 75 percent of the total volume of TCE down to a

  1. Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients

    Directory of Open Access Journals (Sweden)

    João Guilherme Fiorani Borgio

    2012-11-01

    Full Text Available OBJECTIVE: To evaluate the combination of two factors: clinical dementia rating sum of boxes scores (CDR-SB and hippocampal volume (HV as predictors of conversion from mild cognitive impairment (MCI to dementia. METHODS: Twenty-eight individuals (9 normal and 19 with MCI were classified according to their CDR sum of boxes scores into 3 groups. RESULTS: The hippocampal volume was significantly lower in the high-risk group and in those who developed dementia after two years. The rate of conversion was crescent among the three groups. CONCLUSION: We were proposed an additional measurement of the hippocampal volume which may be helpful in the prognosis. However, we noted that the CDR-SB is a method as efficient as neuroimaging to predict dementia with the advantage of being a procedure for low cost and easy implementation, more consistent with public policy.

  2. A Wide Lock-Range Referenceless CDR with Automatic Frequency Acquisition

    OpenAIRE

    Seon-Kyoo Lee; Young-Sang Kim; Hong-June Park; Jae-Yoon Sim

    2011-01-01

    A wide lock-range referenceless CDR circuit is proposed with an automatic tracking of data rate. For efficient frequency acquisition, a DLL-based loop is used with a simple phase/frequency detector to extract 1-bit period of input data stream. The CDR, implemented in a 65 nm CMOS, shows a lock range of 650 Mb/s-to-8 Gb/s and BER of less than 10-12 at 8 Gb/s with low power consumption.

  3. A Wide Lock-Range Referenceless CDR with Automatic Frequency Acquisition

    Directory of Open Access Journals (Sweden)

    Seon-Kyoo Lee

    2011-01-01

    Full Text Available A wide lock-range referenceless CDR circuit is proposed with an automatic tracking of data rate. For efficient frequency acquisition, a DLL-based loop is used with a simple phase/frequency detector to extract 1-bit period of input data stream. The CDR, implemented in a 65 nm CMOS, shows a lock range of 650 Mb/s-to-8 Gb/s and BER of less than 10-12 at 8 Gb/s with low power consumption.

  4. Between Scylla and Charybdis: Delayed mitigation narrows the passage between large-scale CDR and high costs

    Science.gov (United States)

    Strefler, Jessica; Bauer, Nico; Kriegler, Elmar; Popp, Alexander; Giannousakis, Anastasis; Edenhofer, Ottmar

    2018-04-01

    There are major concerns about the sustainability of large-scale deployment of carbon dioxide removal (CDR) technologies. It is therefore an urgent question to what extent CDR will be needed to implement the long term ambition of the Paris Agreement. Here we show that ambitious near term mitigation significantly decreases CDR requirements to keep the Paris climate targets within reach. Following the nationally determined contributions (NDCs) until 2030 makes 2 °C unachievable without CDR. Reducing 2030 emissions by 20% below NDC levels alleviates the trade-off between high transitional challenges and high CDR deployment. Nevertheless, transitional challenges increase significantly if CDR is constrained to less than 5 Gt CO2 a‑1 in any year. At least 8 Gt CO2 a‑1 CDR are necessary in the long term to achieve 1.5 °C and more than 15 Gt CO2 a‑1 to keep transitional challenges in bounds.

  5. Detection of inhibitors of Candida albicans Cdr transporters using a diS-C3(3 fluorescence

    Directory of Open Access Journals (Sweden)

    Joanna eSzczepaniak

    2015-03-01

    Full Text Available Candida albicans is a major cause of opportunistic and life-threatening, systemic fungal infections. Hence new antifungal agents, as well as new methods to treat fungal infections, are still needed. The application of inhibitors of drug-efflux pumps may increase the susceptibility of C. albicans to drugs. We developed a new fluorescence method that allows the in vivo activity evaluation of compounds inhibiting of C. albicans transporters. We show that the potentiometric dye 3,3′-dipropylthiacarbocyanine iodide diS-C3(3 is pumped out by both Cdr1 and Cdr2 transporters. The fluorescence labeling with diS-C3(3 enables a real-time observation of the activity of C. albicans Cdr1 and Cdr2 transporters. We demonstrate that enniatin A and beauvericin show different specificities toward these transporters. Enniatin A inhibits diS-C3(3 efflux by Cdr1 while beauvericin inhibits both Cdr1p and Cdr2p.

  6. Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists.

    Science.gov (United States)

    Liu, Tao; Zhang, Yong; Liu, Yan; Wang, Ying; Jia, Haiqun; Kang, Mingchao; Luo, Xiaozhou; Caballero, Dawna; Gonzalez, Jose; Sherwood, Lance; Nunez, Vanessa; Wang, Danling; Woods, Ashley; Schultz, Peter G; Wang, Feng

    2015-02-03

    On the basis of the 3D structure of a bovine antibody with a well-folded, ultralong complementarity-determining region (CDR), we have developed a versatile approach for generating human or humanized antibody agonists with excellent pharmacological properties. Using human growth hormone (hGH) and human leptin (hLeptin) as model proteins, we have demonstrated that functional human antibody CDR fusions can be efficiently engineered by grafting the native hormones into different CDRs of the humanized antibody Herceptin. The resulting Herceptin CDR fusion proteins were expressed in good yields in mammalian cells and retain comparable in vitro biological activity to the native hormones. Pharmacological studies in rodents indicated a 20- to 100-fold increase in plasma circulating half-life for these antibody agonists and significantly extended in vivo activities in the GH-deficient rat model and leptin-deficient obese mouse model for the hGH and hLeptin antibody fusions, respectively. These results illustrate the utility of antibody CDR fusions as a general and versatile strategy for generating long-acting protein therapeutics.

  7. CLIC Detector Concepts as described in the CDR: Differences between the GEANT4 and Engineering Models

    CERN Document Server

    Elsener, K; Schlatter, D; Siegrist, N

    2011-01-01

    The CLIC_ILD and CLIC_SiD detector concepts as used for the CDR Vol. 2 in 2011 exist both in GEANT4 simulation models and in engineering layout drawings. At this early stage of a conceptual design, there are inevitably differences between these models, which are described in this note.

  8. How Do Scores on the ADAS-Cog, MMSE, and CDR-SOB Correspond?

    Science.gov (United States)

    Balsis, Steve; Benge, Jared F; Lowe, Deborah A; Geraci, Lisa; Doody, Rachelle S

    2015-01-01

    Clinicians and researchers who measure cognitive dysfunction often use the Alzheimer's Disease Assessment Scale--Cognitive Subscale (ADAS-Cog), the Mini-Mental State Examination (MMSE), or the Clinical Dementia Rating scale (CDR-SOB). But, the use of different measures can make it difficult to compare data across patients or studies. What is needed is a simple chart that shows how scores on these three important measures correspond to each other. Using data from 1709 participants from the Alzheimer's Disease Neuroimaging Initiative and item response theory-based statistics, we analyzed how scores on each measure, the ADAS-Cog, the MMSE, and the CDR-SOB, correspond. Results indicated multiple inflections in CDR-SOB and ADAS-Cog scores within a given MMSE score, suggesting that the CDR-SOB and ADAS-Cog are more precise in measuring the severity of cognitive dysfunction than the MMSE. This study shows how scores on these three popular measures of cognitive dysfunction correspond to each other, which is very useful information for both researchers and clinicians.

  9. Refurbishment of uranium hexafluoride cylinder storage yards C-745-K, L, M, N, and P and construction of a new uranium hexafluoride cylinder storage yard (C-745-T) at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    International Nuclear Information System (INIS)

    1996-07-01

    The Paducah Gaseous Diffusion Plant (PGDP) is a uranium enrichment facility owned by the US Department of Energy (DOE). A residual of the uranium enrichment process is depleted uranium hexafluoride (UF6). Depleted UF6, a solid at ambient temperature, is stored in 32,200 steel cylinders that hold a maximum of 14 tons each. Storage conditions are suboptimal and have resulted in accelerated corrosion of cylinders, increasing the potential for a release of hazardous substances. Consequently, the DOE is proposing refurbishment of certain existing yards and construction of a new storage yard. This environmental assessment (EA) evaluates the impacts of the proposed action and no action and considers alternate sites for the proposed new storage yard. The proposed action includes (1) renovating five existing cylinder yards; (2) constructing a new UF6 storage yard; handling and onsite transport of cylinders among existing yards to accommodate construction; and (4) after refurbishment and construction, restacking of cylinders to meet spacing and inspection requirements. Based on the results of the analysis reported in the EA, DOE has determined that the proposed action is not a major Federal action that would significantly affect the quality of the human environment within the context of the National Environmental Policy Act of 1969. Therefore, DOE is issuing a Finding of No Significant Impact. Additionally, it is reported in this EA that the loss of less than one acre of wetlands at the proposed project site would not be a significant adverse impact

  10. Refurbishment of uranium hexafluoride cylinder storage yards C-745-K, L, M, N, and P and construction of a new uranium hexafluoride cylinder storage yard (C-745-T) at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    The Paducah Gaseous Diffusion Plant (PGDP) is a uranium enrichment facility owned by the US Department of Energy (DOE). A residual of the uranium enrichment process is depleted uranium hexafluoride (UF6). Depleted UF6, a solid at ambient temperature, is stored in 32,200 steel cylinders that hold a maximum of 14 tons each. Storage conditions are suboptimal and have resulted in accelerated corrosion of cylinders, increasing the potential for a release of hazardous substances. Consequently, the DOE is proposing refurbishment of certain existing yards and construction of a new storage yard. This environmental assessment (EA) evaluates the impacts of the proposed action and no action and considers alternate sites for the proposed new storage yard. The proposed action includes (1) renovating five existing cylinder yards; (2) constructing a new UF6 storage yard; handling and onsite transport of cylinders among existing yards to accommodate construction; and (4) after refurbishment and construction, restacking of cylinders to meet spacing and inspection requirements. Based on the results of the analysis reported in the EA, DOE has determined that the proposed action is not a major Federal action that would significantly affect the quality of the human environment within the context of the National Environmental Policy Act of 1969. Therefore, DOE is issuing a Finding of No Significant Impact. Additionally, it is reported in this EA that the loss of less than one acre of wetlands at the proposed project site would not be a significant adverse impact.

  11. Theoretical Modeling and Simulation of Phase-Locked Loop (PLL for Clock Data Recovery (CDR

    Directory of Open Access Journals (Sweden)

    Zainab Mohamad Ashari

    2012-01-01

    Full Text Available Modern communication and computer systems require rapid (Gbps, efficient  and large bandwidth data transfers. Agressive scaling of digital integrated systems  allow buses and communication controller circuits to be integrated with the microprocessor on the same chip. The  Peripheral Component Interconnect Express (PCIe protocol handles all communcation between the central processing unit (CPU and hardware devices. PCIe buses require efficient clock data recovery circuits (CDR to recover clock signals embedded in data during transmission. This paper describes the theoretical modeling and simulation of a phase-locked loop (PLL used in a CDR circuit. A simple PLL architecture for a 5 GHz CDR circuit is proposed  and elaborated in this work. Simulations were carried out using a Hardware Description Language, Verilog-AMS. The effect of jitter on the proposed design is also simulated and evaluated in this work. It was found that the proposed design is robust against both input and VCO jitter.ABSTRAK: Sistem komunikasi dan komputer moden memerlukan pemindahan data yang cekap (Gbps, dan bandwidth yang besar. Pengecilan agresif menggunakan teknik sistem digital bersepadu membenarkan bas dan litar pengawal komunikasi disatukan dengan  mikroprocessor dalam cip yang sama. Protokol persisian komponen sambung tara ekspres (PCIe mengendalikan semua komunikasi antara unit pemprosesan pusat (CPU dan peranti perkakasan. Bas PCIe memerlukan litar jam pemulihan data (CDR yang cekap untuk mendapatkan kembali isyarat jam yang tertanam dalam data semasa transmisi. Karya ini menerangkan teori pemodelan dan simulasi gelung fasa terkunci (PLL untuk CDR. Rekabentuk 5 GHz PLL yang mudah telah dicadangkan dalm kertas kerja ini. Simulasi telah dijalankan menggunakan perisian verilog-AMS. Simulasi mengunnakan kesan ketar dalam reka bentuk yang dicadangkan telah dinilai. Reka bentuk yang dicadangkan terbukti teguh mengatasi ganguan ketar di input dan VCO.KEY WORDS

  12. Sampling and Analysis at the Vortec Vitrification Facility in Paducah, Kentucky. Semiannual report, November 1, 1996--March 31, 1997

    International Nuclear Information System (INIS)

    Laudal, Dennis L.; Lillemoen, Carolyn M.; Hurley, John P.; Ness, Sumitra R.; Stepan, Daniel J.; Thompson, Jeffrey S.

    1997-01-01

    The Vortec Cyclone Melting System (CMS) facility; to be located at the U.S. Department of Energy (DOE) Paducah Gaseous Diffusion Plant, is designed to treat soil contaminated with low levels of heavy metals and radioactive elements, as well as organic waste. The primary components of Vortec's CMS are a counter rotating vortex (CRV) reactor and cyclone melter. In the CMS process, granular glass forming ingredients and other feedstocks are introduced into the CRV reactor where the intense CRV mixing allows the mixture to achieve a stable reaction and rapid heating of the feedstock materials. Organic contaminants in the feedstock are effectively oxidized, and the inert inorganic solids are melted. The University of North Dakota Energy ampersand Environmental Research Center (EERC) has been contacted to help in the development of sampling plans and to conduct the sampling at the facility. This document is written in a format that assumes that the EERC will perform the sampling activities and be in charge of sample chain of custody, but that another laboratory will perform required sample analyses

  13. NOAA Climate Data Record (CDR) of Advanced Microwave Sounding Unit (AMSU)-A Brightness Temperature, Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Climate Data Record (CDR) for Advanced Microwave Sounding Unit-A (AMSU-A) brightness temperature in "window channels". The data cover a time period from...

  14. NOAA Climate Data Record (CDR) of SSM/I and SSMIS Microwave Brightness Temperatures, CSU Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) from Colorado State University (CSU) contains brightness temperatures that have been improved and quality-controlled over the...

  15. NOAA Climate Data Record (CDR) of MSU and AMSU-A Mean Layer Temperatures, UAH Version 5.4 (Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Please note: this dataset has been superseded by a newer version (see below). This version is archived offline by NOAA NCEI. This Climate Data Record (CDR) includes...

  16. NOAA Climate Data Record (CDR) of Cloud Properties from AVHRR Pathfinder Atmospheres - Extended (PATMOS-x), Version 5.3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of cloud products was produced by the University of Wisconsin using the AVHRR Pathfinder Atmospheres - Extended (PATMOS-X)...

  17. MESSENGER E/V/H MLA 3/4 CDR/RDR DATA V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — Abstract ======== This data set consists of the MESSENGER Mercury Laser Altimeter (MLA) Calibrated Data Record (CDR) and Reduced Data Record (RDR) products. The MLA...

  18. NOAA Climate Data Record (CDR) of Zonal Mean Ozone Binary Database of Profiles (BDBP), version 1.0

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of Zonal Mean Ozone Binary Database of Profiles (BDBP) dataset is a vertically resolved, global, gap-free and zonal mean dataset...

  19. NOAA Climate Data Record (CDR) of SSM/I and SSMIS Microwave Brightness Temperatures, RSS Version 7

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This Version 7 NOAA Fundamental Climate Data Record (CDR) from Remote Sensing Systems (RSS) contains brightness temperatures that have been inter-calibrated and...

  20. Biological assessment of the effects of construction and operation of a depleted uranium hexafluoride conversion facility at the Paducah, Kentucky, site.

    Energy Technology Data Exchange (ETDEWEB)

    Van Lonkhuyzen, R.

    2005-09-09

    The U.S. Department of Energy (DOE) Depleted Uranium Hexafluoride (DUF{sub 6}) Management Program evaluated alternatives for managing its inventory of DUF{sub 6} and issued the ''Programmatic Environmental Impact Statement for Alternative Strategies for the Long-Term Management and Use of Depleted Uranium Hexafluoride'' (DUF{sub 6} PEIS) in April 1999 (DOE 1999). The DUF{sub 6} inventory is stored in cylinders at three DOE sites: Paducah, Kentucky; Portsmouth, Ohio; and East Tennessee Technology Park (ETTP), near Oak Ridge, Tennessee. In the Record of Decision for the DUF{sub 6} PEIS, DOE stated its decision to promptly convert the DUF6 inventory to a more stable chemical form. Subsequently, the U.S. Congress passed, and the President signed, the ''2002 Supplemental Appropriations Act for Further Recovery from and Response to Terrorist Attacks on the United States'' (Public Law No. 107-206). This law stipulated in part that, within 30 days of enactment, DOE must award a contract for the design, construction, and operation of a DUF{sub 6} conversion plant at the Department's Paducah, Kentucky, and Portsmouth, Ohio, sites, and for the shipment of DUF{sub 6} cylinders stored at ETTP to the Portsmouth site for conversion. This biological assessment (BA) has been prepared by DOE, pursuant to the National Environmental Policy Act of 1969 (NEPA) and the Endangered Species Act of 1974, to evaluate potential impacts to federally listed species from the construction and operation of a conversion facility at the DOE Paducah site.

  1. PHENIX CDR update: An experiment to be performed at the Brookhaven National Laboratory relativistic heavy ion collider. Revision

    International Nuclear Information System (INIS)

    1994-11-01

    The PHENIX Conceptual Design Report Update (CDR Update) is intended for use together with the Conceptual Design Report (CDR). The CDR Update is a companion document to the CDR, and it describes the collaboration's progress since the CDR was submitted in January 1993. Therefore, this document concentrates on changes, refinements, and decisions that have been made over the past year. These documents together define the baseline PHENIX detector that the collaboration intends to build for operation at RHIC startup. In this chapter the current status of the detector and its motivation are briefly described. In Chapters 2 and 3 the detector and the physics performance are more fully developed. In Chapters 4 through 13 the details of the present design status, the technology choices, and the construction costs and schedules are presented. The physics goals of PHENIX collaboration have remained exactly as they were described in the CDR. Primary among these is the detection of a new phase of matter, the quark-gluon plasma (QGP), and the measurement of its properties. The PHENIX experiment will measure many of the best potential QGP signatures to see if any or all of these physics variables show anomalies simultaneously due to the formation of the QGP

  2. TECHNICAL EVALUATION OF TEMPORAL GROUNDWATER MONITORING VARIABILITY IN MW66 AND NEARBY WELLS, PADUCAH GASEOUS DIFFUSION PLANT

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B.; Eddy-Dilek, C.

    2012-08-28

    Evaluation of disposal records, soil data, and spatial/temporal groundwater data from the Paducah Gaseous Diffusion Plant (PGDP) Solid Waste Management Unit (SWMU) 7 indicate that the peak contaminant concentrations measured in monitoring well (MW) 66 result from the influence of the regional PGDP NW Plume, and does not support the presence of significant vertical transport from local contaminant sources in SWMU 7. This updated evaluation supports the 2006 conceptualization which suggested the high and low concentrations in MW66 represent different flow conditions (i.e., local versus regional influences). Incorporation of the additional lines of evidence from data collected since 2006 provide the basis to link high contaminant concentrations in MW66 (peaks) to the regional 'Northwest Plume' and to the upgradient source, specifically, the C400 Building Area. The conceptual model was further refined to demonstrate that groundwater and the various contaminant plumes respond to complex site conditions in predictable ways. This type of conceptualization bounds the expected system behavior and supports development of environmental cleanup strategies, providing a basis to support decisions even if it is not feasible to completely characterize all of the 'complexities' present in the system. We recommend that the site carefully consider the potential impacts to groundwater and contaminant plume migration as they plan and implement onsite production operations, remediation efforts, and reconfiguration activities. For example, this conceptual model suggests that rerouting drainage water, constructing ponds or basin, reconfiguring cooling water systems, capping sites, decommissioning buildings, fixing (or not fixing) water leaks, and other similar actions will potentially have a 'direct' impact on the groundwater contaminant plumes. Our conclusion that the peak concentrations in MW66 are linked to the regional PGDP NW Plume does not imply that

  3. Cooling tower drift studies at the Paducah, Kentucky Gaseous Diffusion Plant. [Transport of drift-derived chromium in terrestrial ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, F.G.; Hanna, S.R.; Parr, P.D.

    1979-01-01

    The transfer and fate of chromium from cooling tower drift to terrestrial ecosystems were quantified at the Department of Energy's uranium enrichment facility at Paducah, Kentucky. Chromium concentrations in plant materials (fescue grass) decreased with increasing distance from the cooing tower, ranging from 251 +- 19 ppM at 15 meters to 0.52 +- 0.07 ppM at 1500 meters. The site of drift contamination, size characteristics, and elemental content of drift particles were determined using a scanning electron microscope with energy dispersive x-ray analysis capabilities. Results indicate that elemental content in drift water (mineral residue) may not be equivalent to the content in the recirculating cooling water of the tower. This hypothesis is contrary to basic assumptions in calculating drift emissions. A laboratory study simulating throughfall from 1 to 6 inches of rain suggested that there are more exchange sites associated with litter than live foliage. Leachate from each one inch throughfall simulant removed 3% of the drift mass from litter compared to 7 to 9% from live foliage. Results suggest that differences in retention are related to chemical properties of the drift rather than physical lodging of the particle residue. To determine the potential for movement of drift-derived chromium to surface streams, soil--water samplers (wells) were placed along a distance gradient to Little Bayou Creek. Samples from two depths following rainstorms revealed the absence of vertical or horizontal movement with maximum concentrations of 0.13 ppb at 50 meters from the tower. Preliminary model estimates of drift deposition are compared to depositionmeasurements. Isopleths of the predicted deposition are useful to identify areas of maximum drift transport in the environs of the gaseous diffusion plant.

  4. T cells to a dominant epitope of GAD65 express a public CDR3 motif.

    Science.gov (United States)

    Quinn, Anthony; McInerney, Marcia; Huffman, Donald; McInerney, Brigid; Mayo, Stella; Haskins, Kathryn; Sercarz, Eli

    2006-06-01

    Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes, and serve as a model for type 1 diabetes (T1D) and natural autoimmunity. T cell responses to the pancreatic islet antigen glutamic acid decarboxylase 65 (GAD65) can be detected in the spleens of young prediabetic NOD mice, which display a unique MHC class II molecule. Here, we report that a distinct TcR beta chain and CDR3 motif are utilized by all NOD mice in response to a dominant determinant on GAD65, establishing a public repertoire in the spontaneous autoimmunity to an important islet cell antigen. GAD65 530-543 (p530)-reactive T cells preferentially utilize the Vbeta4, Dbeta2.1 and Jbeta2.7 gene segments, with a CDR3 that is characterized by a triad of amino acids, DWG, preceded by a polar residue. In addition, we used CDR3 length spectratyping, CDR3-specific reverse transcriptase-PCR and direct TcR sequencing to show that the TcR beta chain structural patterns associated with p530-specific T cells consistently appeared in the islets of young NOD mice with insulitis, but not in the inflamed islets of streptozotocin-treated C57BL/6 mice, or in inflamed NOD salivary glands. To our knowledge, this is the first report to demonstrate that a public T cell repertoire is used in spontaneous autoimmunity to a dominant self-determinant. These findings suggest that defined clonotypes and repertoires may be preferentially selected in haplotypes predisposed to spontaneous autoimmunity.

  5. The physics benchmark processes for the detector performance studies used in CLIC CDR Volume 3

    CERN Document Server

    Allanach, B.J.; Desch, K.; Ellis, J.; Giudice, G.; Grefe, C.; Kraml, S.; Lastovicka, T.; Linssen, L.; Marschall, J.; Martin, S.P.; Muennich, A.; Poss, S.; Roloff, P.; Simon, F.; Strube, J.; Thomson, M.; Wells, J.D.

    2012-01-01

    This note describes the detector benchmark processes used in volume 3 of the CLIC conceptual design report (CDR), which explores a staged construction and operation of the CLIC accelerator. The goal of the detector benchmark studies is to assess the performance of the CLIC ILD and CLIC SiD detector concepts for different physics processes and at a few CLIC centre-of-mass energies.

  6. Evaluation of PERSIANN-CDR for Meteorological Drought Monitoring over China

    Directory of Open Access Journals (Sweden)

    Hao Guo

    2016-05-01

    Full Text Available In this paper, Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks–Climate Data Record (PERSIANN-CDR is analyzed for the assessment of meteorological drought. The evaluation is conducted over China at 0.5° spatial resolution against a ground-based gridded China monthly Precipitation Analysis Product (CPAP from 1983 to 2014 (32 years. The Standardized Precipitation Index (SPI at various time scales (1 month to 12 months is calculated for detecting drought events. The results show that PERSIANN-CDR depicts similar drought behavior as the ground-based CPAP in terms of capturing the spatial and temporal patterns of drought events over eastern China, where the intensity of gauge networks and the frequency of droughts are high. 6-month SPI shows the best agreement with CPAP in identifying drought months. However, large differences between PERSIANN-CDR and CPAP in depicting drought patterns and identifying specific drought events are found over northwestern China, particularly in Xinjiang and Qinghai-Tibet Plateau region. Factors behind this may be due to the relatively sparse gauge networks, the complicated terrain and the performance of PERSIANN algorithm.

  7. Procedures in child deaths in The Netherlands: a comparison with child death review

    OpenAIRE

    Knoeff-Gijzen, Sandra; Petter, Jessica; L'Hoir, Monique P.; Boere-Boonekamp, Magdalena M.; Need, Ariana

    2017-01-01

    Aim: Child Death Review (CDR) is a method in which every child death is systematically and multidisciplinary examined to (1) improve death statistics, (2) identify factors that give direction for prevention, (3) translate the results into possible interventions, and (4) support families. The aim of this study was to determine to what extent procedures of organizations involved in the (health) care for children in The Netherlands cover these four objectives of CDR. Subject and methods: Organiz...

  8. JMBR VOLUME 15 Number 1 JUNE 2016 - correction.cdr

    African Journals Online (AJOL)

    Fineprint

    2016-06-01

    Jun 1, 2016 ... JMBR: A Peer-review Journal of Biomedical Sciences. June 2016, Vol. 15 No. ... Combination therapy, Plasmodium falciparum. Introduction. Multidrug .... JMBR 2016:15(1). 76....Journal of Medicine and Biomedical Research ...

  9. NJP Volume 38 Number 1 PDF.cdr

    African Journals Online (AJOL)

    Prof Ezechukwu

    reviewers have limited capacity to pick up duplicate, redundant or even plagiarized papers so that, ultimately, the integrity of any published paper rests with the individual author . Authors guarantee the integrity of scientific literature. We must hold ourselves accountable. How to avoid duplicate and/redundant publication.

  10. JMBR VOLUME 15 Number 2 Decemebr 2016 - correction.cdr

    African Journals Online (AJOL)

    Fine Print

    across the country; stock-outs of antiretroviral medications in several health facilities and irregular supply of. 7 rapid HIV test kits, etc. Without specific intervention, the relatively high prevalence of HIV infection in Benin City increases risk of. MTCT of HIV infection, in Benin City. This creates an urgent need to review,.

  11. Turkish Cloud-Radiation Database (CRD) and Its Application with CDR Bayesian Probability Algorithm

    Science.gov (United States)

    Oztopal, A.; Mugnai, A.; Casella, D.; Formenton, M.; Sano, P.; Sonmez, I.; Sen, Z.; Hsaf Team

    2010-12-01

    ABSTRACT It is rather a very difficult task to determine ground rainfall amounts from few Special Sensor Microwave Imager/Sounder (SSMI/S) channels. Although ground rainfall cannot be observed from the space directly, but knowledge about the cloud physics helps to estimate the amound of ground rainfall. SSMI/S includes so much information about the atmospheric structure, however it cannot provide cloud micro-physical structural information. In such a situation, in the rainfall algorithm, besides the SSMI/S data, it is necessary to incorporate cloud micro-physical properties from an external data source. These properties can be obtained quite simply by the help of Cloud Resolving Model (CRM). Later, in addition to all available data, also micro-physical properties obtained from Radiative Transfer Model (RTM) help to determine the SSMI/S brightness temperatures (Brightness temperatures - TBs), which can then be correlated with Cloud-Radiation Database (CRD) data generation. SSMI/S satellite data and CDR provide a common basis for rainfall prediction procedure through CDR Bayesian probability algorithm, which combines the two sets of data in a scientific manner. The first applications of this algorithm, which is being used up today, is due to various researchers. In this work, in order to establish a reflection of available data processing CDR CRM University of Wisconsin - Non-hydrostatic Modeling System (UW-NMS) model is employed, which is first developed by Prof. Gregory J. Tripoli. It is also used by Turkish Meteorological Service by benefiting from radar network data, and finally 14 simulations are realized in this study. Moreover, one case study is fulfilled by using a 3X3 spatial filtering, and then radar data and result of CDR Bayesian probability algorithm are compared with each other. On 9 September 2009 at 03:40 GMT rainfall event on comparatively flat area matches far better with the retrieval values and hence the spatial rainfall occurrence extent and

  12. COMBINED GEOPHYSICAL INVESTIGATION TECHNIQUES TO IDENTIFY BURIED WASTE IN AN UNCONTROLLED LANDFILL AT THE PADUCAH GASEOUS DIFFUSION PLANT, KENTUCKY

    International Nuclear Information System (INIS)

    Miller, Peter T.; Starmer, R. John

    2003-01-01

    The primary objective of the investigation was to confirm the presence and determine the location of a cache of 30 to 60 buried 55-gallon drums that were allegedly dumped along the course of the pre-existing, northsouth diversion ditch (NSDD) adjacent to permitted landfills at the Paducah Gaseous Diffusion Plant, Kentucky. The ditch had been rerouted and was being filled and re-graded at the time of the alleged dumping. Historic information and interviews with individuals associated with alleged dumping activities indicated that the drums were dumped prior to the addition of other fill materials. In addition, materials alleged to have been dumped in the ditch, such as buried roofing materials, roof flashing, metal pins, tar substances, fly ash, and concrete rubble complicated data interpretation. Some clean fill materials have been placed over the site and graded. This is an environment that is extremely complicated in terms of past waste dumping activities, construction practices and miscellaneous landfill operations. The combination of site knowledge gained from interviews and research of existing site maps, variable frequency EM data, classical total magnetic field data and optimized GPR lead to success where a simpler less focused approach by other investigators using EM-31 and EM-61 electromagnetic methods and unfocused ground penetrating radar (GPR)did not produce results and defined no real anomalies. A variable frequency electromagnetic conductivity unit was used to collect the EM data at 3,030 Hz, 5,070 Hz, 8,430 Hz, and 14,010 Hz. Both in-phase and quadrature components were recorded at each station point. These results provided depth estimates for targets and some information on the subsurface conditions. A standard magnetometer was used to conduct the magnetic survey that showed the locations and extent of buried metal, the approximate volume of ferrous metal present within a particular area, and allowed estimation of approximate target depths. The GPR

  13. COMBINED GEOPHYSICAL INVESTIGATION TECHNIQUES TO IDENTIFY BURIED WASTE IN AN UNCONTROLLED LANDFILL AT THE PADUCAH GASEOUS DIFFUSION PLANT, KENTUCKY

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Peter T.; Starmer, R. John

    2003-02-27

    The primary objective of the investigation was to confirm the presence and determine the location of a cache of 30 to 60 buried 55-gallon drums that were allegedly dumped along the course of the pre-existing, northsouth diversion ditch (NSDD) adjacent to permitted landfills at the Paducah Gaseous Diffusion Plant, Kentucky. The ditch had been rerouted and was being filled and re-graded at the time of the alleged dumping. Historic information and interviews with individuals associated with alleged dumping activities indicated that the drums were dumped prior to the addition of other fill materials. In addition, materials alleged to have been dumped in the ditch, such as buried roofing materials, roof flashing, metal pins, tar substances, fly ash, and concrete rubble complicated data interpretation. Some clean fill materials have been placed over the site and graded. This is an environment that is extremely complicated in terms of past waste dumping activities, construction practices and miscellaneous landfill operations. The combination of site knowledge gained from interviews and research of existing site maps, variable frequency EM data, classical total magnetic field data and optimized GPR lead to success where a simpler less focused approach by other investigators using EM-31 and EM-61 electromagnetic methods and unfocused ground penetrating radar (GPR)did not produce results and defined no real anomalies. A variable frequency electromagnetic conductivity unit was used to collect the EM data at 3,030 Hz, 5,070 Hz, 8,430 Hz, and 14,010 Hz. Both in-phase and quadrature components were recorded at each station point. These results provided depth estimates for targets and some information on the subsurface conditions. A standard magnetometer was used to conduct the magnetic survey that showed the locations and extent of buried metal, the approximate volume of ferrous metal present within a particular area, and allowed estimation of approximate target depths. The GPR

  14. BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome

    International Nuclear Information System (INIS)

    Pickman, Yishai; Mehr, Ramit; Dunn-Walters, Deborah

    2013-01-01

    Complementarity-determining region 3 (CDR3) is the most hyper-variable region in B cell receptor (BCR) and T cell receptor (TCR) genes, and the most critical structure in antigen recognition and thereby in determining the fates of developing and responding lymphocytes. There are millions of different TCR Vβ chain or BCR heavy chain CDR3 sequences in human blood. Even now, when high-throughput sequencing becomes widely used, CDR3 length distributions (also called spectratypes) are still a much quicker and cheaper method of assessing repertoire diversity. However, distribution complexity and the large amount of information per sample (e.g. 32 distributions of the TCRα chain, and 24 of TCRβ) calls for the use of machine learning tools for full exploration. We have examined the ability of supervised machine learning, which uses computational models to find hidden patterns in predefined biological groups, to analyze CDR3 length distributions from various sources, and distinguish between experimental groups. We found that (a) splenic BCR CDR3 length distributions are characterized by low standard deviations and few local maxima, compared to peripheral blood distributions; (b) healthy elderly people's BCR CDR3 length distributions can be distinguished from those of the young; and (c) a machine learning model based on TCR CDR3 distribution features can detect myelodysplastic syndrome with approximately 93% accuracy. Overall, we demonstrate that using supervised machine learning methods can contribute to our understanding of lymphocyte repertoire diversity. (paper)

  15. CDR3 analysis of TCR Vβ repertoire of CD8⁺ T cells from chickens infected with Eimeria maxima.

    Science.gov (United States)

    Ren, Chao; Yin, Guangwen; Qin, Mei; Suo, Jingxia; Lv, Qiyao; Xie, Li; Wang, Yunzhou; Huang, Xiaoxi; Chen, Yuchen; Liu, Xianyong; Suo, Xun

    2014-08-01

    CD8(+) T cells play a major role in the immune protection of host against the reinfection of Eimeria maxima, the most immunogenic species of eimerian parasites in chickens. To explore the dominant complementarity-determining regions 3 (CDR3) of CD8(+) T cell populations induced by the infection of this parasite, sequence analysis was performed in this study for CDR3 of CD8(+) T cells from E. maxima infected chickens. After 5 days post the third or forth infection, intraepithelial lymphocytes were isolated from the jejunum of bird. CD3(+)CD8(+) T cells were sorted and subjected to total RNA isolation and cDNA preparation. PCR amplification and cloning of the loci between Vβ1 and Cβ was conducted for the subsequent sequencing of CDR3 of T cell receptor (TCR). After the forth infection, 2 birds exhibited two same frequent TCR CDR3 sequences, i.e., AKQDWGTGGYSNMI and AGRVLNIQY; while the third bird showed two different frequent TCR CDR3 sequences, AKQGARGHTPLN and AKQDIEVRGPNTPLN. No frequent CDR3 sequence was detected from uninfected birds, though AGRVLNIQY was also found in two uninfected birds. Our result preliminarily demonstrates that frequent CDR3 sequences may exist in E. maxima immunized chickens, encouraging the mining of the immunodominant CD8(+) T cells against E. maxima infection. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome

    Science.gov (United States)

    Pickman, Yishai; Dunn-Walters, Deborah; Mehr, Ramit

    2013-10-01

    Complementarity-determining region 3 (CDR3) is the most hyper-variable region in B cell receptor (BCR) and T cell receptor (TCR) genes, and the most critical structure in antigen recognition and thereby in determining the fates of developing and responding lymphocytes. There are millions of different TCR Vβ chain or BCR heavy chain CDR3 sequences in human blood. Even now, when high-throughput sequencing becomes widely used, CDR3 length distributions (also called spectratypes) are still a much quicker and cheaper method of assessing repertoire diversity. However, distribution complexity and the large amount of information per sample (e.g. 32 distributions of the TCRα chain, and 24 of TCRβ) calls for the use of machine learning tools for full exploration. We have examined the ability of supervised machine learning, which uses computational models to find hidden patterns in predefined biological groups, to analyze CDR3 length distributions from various sources, and distinguish between experimental groups. We found that (a) splenic BCR CDR3 length distributions are characterized by low standard deviations and few local maxima, compared to peripheral blood distributions; (b) healthy elderly people's BCR CDR3 length distributions can be distinguished from those of the young; and (c) a machine learning model based on TCR CDR3 distribution features can detect myelodysplastic syndrome with approximately 93% accuracy. Overall, we demonstrate that using supervised machine learning methods can contribute to our understanding of lymphocyte repertoire diversity.

  17. Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.

    Directory of Open Access Journals (Sweden)

    Gediminas Matulis

    2010-06-01

    Full Text Available Invariant Natural Killer T cells (iNKT are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance. They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule CD1d. The structure of human iNKT TCRs is unique in that only one of the six complementarity determining region (CDR loops, CDR3beta, is hypervariable. The role of this loop for iNKT biology has been controversial, and it is unresolved whether it contributes to iNKT TCR:CD1d binding or antigen selectivity. On the one hand, the CDR3beta loop is dispensable for iNKT TCR binding to CD1d molecules presenting the xenobiotic alpha-galactosylceramide ligand KRN7000, which elicits a strong functional response from mouse and human iNKT cells. However, a role for CDR3beta in the recognition of CD1d molecules presenting less potent ligands, such as self-lipids, is suggested by the clonal distribution of iNKT autoreactivity. We demonstrate that the human iNKT repertoire comprises subsets of greatly differing TCR affinity to CD1d, and that these differences relate to their autoreactive functions. These functionally different iNKT subsets segregate in their ability to bind CD1d-tetramers loaded with the partial agonist alpha-linked glycolipid antigen OCH and structurally different endogenous beta-glycosylceramides. Using surface plasmon resonance with recombinant iNKT TCRs and different ligand-CD1d complexes, we demonstrate that the CDR3beta sequence strongly impacts on the iNKT TCR affinity to CD1d, independent of the loaded CD1d ligand. Collectively our data reveal a crucial role for CDR3beta for the function of human iNKT cells by tuning the overall affinity of the iNKT TCR to CD1d. This mechanism is relatively independent of the bound CD1d ligand and thus forms the basis of an inherent, CDR3beta dependent functional hierarchy of human iNKT cells.

  18. A Climate-Data Record (CDR) of the "Clear-Sky" Surface Temperature of the Greenland Ice Sheet

    Science.gov (United States)

    Hall, Dorothy K.; Comiso, Josefino C.; DiGirolamo, Nocolo E.; Shuman, Christopher A.

    2011-01-01

    We have developed a climate-data record (CDR) of "clear-sky" ice-surface temperature (IST) of the Greenland Ice Sheet using Moderate-Resolution Imaging Spectroradiometer (MODIS) data. The CDR provides daily and monthly-mean IST from March 2000 through December 2010 on a polar stereographic projection at a resolution of 6.25 km. The CDR is amenable to extension into the future using Visible/Infrared Imager Radiometer Suite (VIIRS) data. Regional "clear-sky" surface temperature increases since the early 1980s in the Arctic, measured using Advanced Very High Resolution Radiometer (AVHRR) infrared data, range from 0.57 +/- 0.02 to 0.72 +/- 0.1 c per decade. Arctic warming has important implications for ice-sheet mass balance because much of the periphery of the Greenland Ice Sheet is already near O C during the melt season, and is thus vulnerable to rapid melting if temperatures continue to increase. An increase in melting of the ice sheet would accelerate sea-level rise, an issue affecting potentially billions of people worldwide. The IST CDR will provide a convenient data set for modelers and for climatologists to track changes of the surface temperature of the ice sheet as a whole and of the individual drainage basins on the ice sheet. The daily and monthly maps will provide information on surface melt as well as "clear-sky" temperature. The CDR will be further validated by comparing results with automatic-weather station data and with satellite-derived surface-temperature products.

  19. A ‘Social Form Of Knowledge’ in Practice: Unofficial Compiling of 1960s Pop Music on CD-R

    Directory of Open Access Journals (Sweden)

    Paul Martin

    2012-01-01

    Full Text Available In this article I explore the ‘unofficial’ (and technically illegal compiling of marginally known 1960s pop records on Compact Disc Recordable (CD-R. I do so by situating it within the proposition by the late Raphael Samuel, that history is ‘social knowledge’ and a practice rather than a profession. I propose that this compiling activity exemplifies this proposition. The core of the paper is centred on a 2007 survey which I conducted via three on-line 1960s music enthusiast discussion forums. I draw on the sixteen responses to demonstrate how the motivations, values and intentions of those respondents engaging in the practice of CD-R compiling are historically and socially centred. In doing so, I seek to problematise the music industry’s undifferentiated condemnation of all copying as theft. I do so by showing how, far from stealing, these CD-R compilers are adding to the musical social knowledge of 1960s pop and rock music. I further situate them within a longer lineage of ‘unofficial listening’ dating back to at least the 1930s. In using the term ‘unofficial’ in both a legal and public historical sense (eg to take issue with a received narrative, I point to wider definitions of what historically has or has not been musically ‘official’ to listen to. I seek also to point to the practice of CD-R compiling as a historical ‘moment’ in technological change, which might otherwise go unremarked upon as the CD-R itself heads towards utilitarian obsolescence. Although, the issues and concepts raised in the paper can be little more than pointed to, it is hoped it might act as one platform for the historical engagement with a subject more commonly discussed in sociological terms. As public historians we should be reflexive and inter-disciplinary and it is with this mind set that this article is written.

  20. Ambiguity Function Analysis and Processing for Passive Radar Based on CDR Digital Audio Broadcasting

    Directory of Open Access Journals (Sweden)

    Zhang Qiang

    2015-01-01

    Full Text Available China Digital Radio (CDR broadcasting is a new standard of digital audio broadcasting of FM frequency (87–108 MHz based on our research and development efforts. It is compatible with the frequency spectrum in analog FM radio and satisfies the requirements for smooth transition from analog to digital signal in FM broadcasting in China. This paper focuses on the signal characteristics and processing methods of radio-based passive radar. The signal characteristics and ambiguity function of a passive radar illumination source are analyzed. The adverse effects on the target detection of the side peaks owing to cyclic prefix, the Doppler ambiguity strips because of signal synchronization, and the range of side peaks resulting from the signal discontinuous spectrum are then studied. Finally, methods for suppressing these side peaks are proposed and their effectiveness is verified by simulations.

  1. NOAA Climate Data Record (CDR) of Intersatellite Calibrated Clear-Sky HIRS Channel 12 Brightness Temperature, Version 2.6 (Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of Inter-Satellite Calibrated Clear-Sky High Resolution Infrared Radiation Sounder (HIRS) Channel 12 brightness temperatures...

  2. NOAA Climate Data Record (CDR) of Reflectance and Brightness Temperatures from AVHRR Pathfinder Atmospheres - Extended (PATMOS-x), Version 5.3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) of AVHRR reflectance and brightness temperatures was produced by the University of Wisconsin using the AVHRR Pathfinder...

  3. NOAA Climate Data Record (CDR) of AVHRR Daily and Monthly Aerosol Optical Thickness (AOT) over Global Oceans, Version 3.0

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The product is the aerosol optical thickness (AOT) at 0.63 micron, which is retrieved from NOAA PATMOS-x level-2B orbital radinace and cloud CDR products. The...

  4. NOAA Climate Data Record (CDR) of GPS RO-Calibrated AMSU Channel 7 (Temperatures of Troposphere / Stratosphere, TTS), Version 1.0 (Version Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Climate Data Records (CDR) for Channel 7 contains Radio Occulation (RO) calibrated brightness temperatures from AMSU-A channel 7 measurements at 54.9 GHz from...

  5. A Climate Data Record (CDR) for the global terrestrial water budget: 1984-2010

    Science.gov (United States)

    Zhang, Yu; Pan, Ming; Sheffield, Justin; Siemann, Amanda L.; Fisher, Colby K.; Liang, Miaoling; Beck, Hylke E.; Wanders, Niko; MacCracken, Rosalyn F.; Houser, Paul R.; Zhou, Tian; Lettenmaier, Dennis P.; Pinker, Rachel T.; Bytheway, Janice; Kummerow, Christian D.; Wood, Eric F.

    2018-01-01

    Closing the terrestrial water budget is necessary to provide consistent estimates of budget components for understanding water resources and changes over time. Given the lack of in situ observations of budget components at anything but local scale, merging information from multiple data sources (e.g., in situ observation, satellite remote sensing, land surface model, and reanalysis) through data assimilation techniques that optimize the estimation of fluxes is a promising approach. Conditioned on the current limited data availability, a systematic method is developed to optimally combine multiple available data sources for precipitation (P), evapotranspiration (ET), runoff (R), and the total water storage change (TWSC) at 0.5° spatial resolution globally and to obtain water budget closure (i.e., to enforce P - ET - R - TWSC = 0) through a constrained Kalman filter (CKF) data assimilation technique under the assumption that the deviation from the ensemble mean of all data sources for the same budget variable is used as a proxy of the uncertainty in individual water budget variables. The resulting long-term (1984-2010), monthly 0.5° resolution global terrestrial water cycle Climate Data Record (CDR) data set is developed under the auspices of the National Aeronautics and Space Administration (NASA) Earth System Data Records (ESDRs) program. This data set serves to bridge the gap between sparsely gauged regions and the regions with sufficient in situ observations in investigating the temporal and spatial variability in the terrestrial hydrology at multiple scales. The CDR created in this study is validated against in situ measurements like river discharge from the Global Runoff Data Centre (GRDC) and the United States Geological Survey (USGS), and ET from FLUXNET. The data set is shown to be reliable and can serve the scientific community in understanding historical climate variability in water cycle fluxes and stores, benchmarking the current climate, and

  6. Expression of cold and drought regulatory protein (CcCDR) of pigeonpea imparts enhanced tolerance to major abiotic stresses in transgenic rice plants.

    Science.gov (United States)

    Sunitha, Mellacheruvu; Srinath, Tamirisa; Reddy, Vudem Dashavantha; Rao, Khareedu Venkateswara

    2017-06-01

    Transgenic rice expressing pigeonpea Cc CDR conferred high-level tolerance to different abiotic stresses. The multiple stress tolerance observed in CcCDR -transgenic lines is attributed to the modulation of ABA-dependent and-independent signalling-pathway genes. Stable transgenic plants expressing Cajanus cajan cold and drought regulatory protein encoding gene (CcCDR), under the control of CaMV35S and rd29A promoters, have been generated in indica rice. Different transgenic lines of CcCDR, when subjected to drought, salt, and cold stresses, exhibited higher seed germination, seedling survival rates, shoot length, root length, and enhanced plant biomass when compared with the untransformed control plants. Furthermore, transgenic plants disclosed higher leaf chlorophyll content, proline, reducing sugars, SOD, and catalase activities, besides lower levels of MDA. Localization studies revealed that the CcCDR-GFP fusion protein was mainly present in the nucleus of transformed cells of rice. The CcCDR transgenics were found hypersensitive to abscisic acid (ABA) and showed reduced seed germination rates as compared to that of control plants. When the transgenic plants were exposed to drought and salt stresses at vegetative and reproductive stages, they revealed larger panicles and higher number of filled grains compared to the untransformed control plants. Under similar stress conditions, the expression levels of P5CS, bZIP, DREB, OsLEA3, and CIPK genes, involved in ABA-dependent and-independent signal transduction pathways, were found higher in the transgenic plants than the control plants. The overall results amply demonstrate that the transgenic rice expressing CcCDR bestows high-level tolerance to drought, salt, and cold stress conditions. Accordingly, the CcCDR might be deployed as a promising candidate gene for improving the multiple stress tolerance of diverse crop plants.

  7. JOPATW~1.cdr 08.cdr

    African Journals Online (AJOL)

    tablets, the mechanism and kinetics of drug delivery were studied. ... different pH environments with a characteristic swelling ratio of 12 and 5 in ... stored in an air tight container and placed in a desiccator until used. ... Tablet physical quality.

  8. JOPATW~1.cdr 08.cdr

    African Journals Online (AJOL)

    4HIV Vaccine Trial Unit, Asokoro District Hospital, Abuja, Nigeria. Abstract ... for patient management and prevention of new infections and a number of test kits by different ... arriving HIV antibody detection assays are dynamic process. ... personnel should not only pay attention to public awareness about HIV/AIDS but.

  9. Thermal discharges from Paducah Gaseous Diffusion Plant outfalls: Impacts on stream temperatures and fauna of Little Bayou and Big Bayou Creeks

    Energy Technology Data Exchange (ETDEWEB)

    Roy, W.K.; Ryon, M.G.; Hinzman, R.L. [Oak Ridge National Lab., TN (United States). Computer Science and Mathematics Div.

    1996-03-01

    The development of a biological monitoring plan for the receiving streams of the Paducah Gaseous Diffusion Plant (PGDP) began in the late 1980s, because of an Agreed Order (AO) issued in September 1987 by the Kentucky Division of Water (KDOW). Five years later, in September 1992, more stringent effluent limitations were imposed upon the PGDP operations when the KDOW reissued Kentucky Pollutant Discharge Elimination System permit No. KY 0004049. This action prompted the US Department of Energy (DOE) to request a stay of certain limits contained in the permit. An AO is being negotiated between KDOW, the US Enrichment Corporation (USEC), and DOE that will require that several studies be conducted, including this stream temperature evaluation study, in an effort to establish permit limitations. All issues associated with this AO have been resolved, and the AO is currently being signed by all parties involved. The proposed effluent temperature limit is 89 F (31.7 C) as a mean monthly temperature. In the interim, temperatures are not to exceed 95 F (35 C) as a monthly mean or 100 F (37.8 C) as a daily maximum. This study includes detailed monitoring of instream temperatures, benthic macroinvertebrate communities, fish communities, and a laboratory study of thermal tolerances.

  10. Task 16 -- Sampling and analysis at the Vortec vitrification facility in Paducah, Kentucky. Semi-annual report, April 1--September 30, 1997

    International Nuclear Information System (INIS)

    Laudal, D.L.; Lilemoen, C.M.; Hurley, J.P.; Ness, S.R.; Stepan, D.J.; Thompson, J.S.

    1997-05-01

    The Vortec Cyclone Melting System (CMS reg-sign) facility, to be located at the US Department of Energy (DOE) Paducah Gaseous Diffusion Plant, is designed to treat soil contaminated with low levels of heavy metals and radioactive elements, as well as organic waste. To assure that costs of sampling and analysis are contained, Vortec and the DOE Federal Energy Technology Center (FETC) have decided that initially the primary focus of the sampling activities will be on meeting permitting requirements of the state of Kentucky. Therefore, sampling will be limited to the feedstock entering the system, and the glass, flue gas, and water leaving the system. The authors provide suggestions for optional sampling points and procedures in case there is later interest in operations or mass balance data. The permits do not require speciation of the materials in the effluents, only opacity, total radioactivity, total particulate, and total HCl emissions for the gaseous emissions and total radioactivity in the water and solid products. In case future testing to support operations or mass balances is required, the authors include in this document additional information on the analyses of some species of interest. They include heavy metals (RCRA [Resource Conservation and Recovery Act] and Cu and Ni), radionuclides (Th 230 , U 235 , Tc 99 , Cs 137 , and Pu 239 ), and dioxins/furans

  11. CHANGING THE LANDSCAPE--LOW-TECH SOLUTIONS TO THE PADUCAH SCRAP METAL REMOVAL PROJECT ARE PROVIDING SAFE, COST-EFFECTIVE REMEDIATION OF CONTAMINATED SCRAP YARDS

    International Nuclear Information System (INIS)

    Watson, Dan; Eyman, Jeff

    2003-01-01

    Between 1974 and 1983, contaminated equipment was removed from the Paducah Gaseous Diffusion Plant (PGDP) process buildings as part of an enrichment process upgrade program. The upgrades consisted of the dismantlement, removal, and on-site storage of contaminated equipment, cell components, and scrap material (e.g., metal) from the cascade facilities. Scrap metal including other materials (e.g., drums, obsolete equipment) not related to this upgrade program have thus far accumulated in nine contiguous radiologically-contaminated and non-contaminated scrap yards covering 1.05E5 m2 (26 acres) located in the northwestern portion of the PGDP. This paper presents the sequencing of field operations and methods used to achieve the safe removal and disposition of over 47,000 tonnes (53,000 tons) of metal and miscellaneous items contained in these yards. The methods of accomplishment consist of mobilization, performing nuclear criticality safety evaluations, moving scrap metal to ground level, inspection and segregation, sampling and characterization, scrap metal sizing, packaging and disposal, and finally demobilization. Preventing the intermingling of characteristically hazardous and non-hazardous wastes promotes waste minimization, allowing for the metal and materials to be segregated into 13 separate waste streams. Low-tech solutions such as using heavy equipment to retrieve, size, and package scrap materials in conjunction with thorough planning that integrates safe work practices, commitment to teamwork, and incorporating lessons learned ensures that field operations will be conducted efficiently and safely

  12. Application of the electromagnetic borehole flowmeter and evaluation of previous pumping tests at Paducah Gaseous Diffusion Plant. Final report, June 15, 1992--August 31, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Young, S.C.; Julian, S.C.; Neton, M.J.

    1993-01-01

    Multi-well pumping tests have been concluded at wells MW79, MW108, and PW1 at the Paducah Gaseous Diffusion Plant (PGDP) to determine the hydraulic properties of the Regional Gravel Aquifer (RGA). Soil cores suggest that the RGA consists of a thin sandy facies (2 to 6 feet) at the top of a thicker (> 10 feet) gravelly facies. Previous analyses have not considered any permeability contrast between the two facies. To assess the accuracy of this assumption, TVA personnel conducted borehole flowmeter tests at wells MW108 and PW1. Well MW79 could not be tested. The high K sand unit is probably 10 times more permeable than comparable zone in the gravelly portion of the RGA. Previous analyses of the three multi-well aquifer tests do not use the same conceptual aquifer model. Data analysis for one pumping test assumed that leakance was significant. Data analysis for another pumping test assumed that a geologic boundary was significant. By collectively analyzing all three tests with the borehole flowmeter results, the inconsistency among the three pumping tests can be explained. Disparity exists because each pumping test had a different placement of observation wells relative to the high K zone delineating by flowmeter testing.

  13. Applicable or relevant and appropriate requirements (ARARs) for remedial actions at the Paducah Gaseous Diffusion Plant: A compendium of environmental laws and guidance

    International Nuclear Information System (INIS)

    Etnier, E.L.; Eaton, L.A.

    1992-03-01

    Section 121 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 specifies that remedial actions for cleanup of hazardous substances found at sites placed on the National Priorities List (NPL) by the US Environmental Protection Agency (EPA) must comply with applicable or relevant and appropriate requirements (ARARs) or standards under federal and state environmental laws. To date, the US Department of Energy (DOE) Paducah Gaseous Diffusion Plant (PGDP) has not been on the NPL. Although DOE and EPA have entered into an Administrative Consent Order (ACO), the prime regulatory authority for cleanup at PGDP will be the Resource Conservation and Recovery Act (RCRA). This report supplies a preliminary list of available federal and state ARARs that might be considered for remedial response at PGDP in the event that the plant becomes included on the NPL or the ACO is modified to include CERCLA cleanup. A description of the terms ''applicable'' and ''relevant and appropriate'' is provided, as well as definitions of chemical-, location-, and action-specific ARARS. ARARs promulgated by the federal government and by the state of Kentucky are listed in tables. In addition, the major provisions of RCRA, the Safe Drinking Water Act, the Clean Water Act, the Clean Air Act, and other acts, as they apply to hazardous and radioactive waste cleanup, are discussed

  14. Thermal discharges from Paducah Gaseous Diffusion Plant outfalls: Impacts on stream temperatures and fauna of Little Bayou and Big Bayou Creeks

    International Nuclear Information System (INIS)

    Roy, W.K.; Ryon, M.G.; Hinzman, R.L.

    1996-03-01

    The development of a biological monitoring plan for the receiving streams of the Paducah Gaseous Diffusion Plant (PGDP) began in the late 1980s, because of an Agreed Order (AO) issued in September 1987 by the Kentucky Division of Water (KDOW). Five years later, in September 1992, more stringent effluent limitations were imposed upon the PGDP operations when the KDOW reissued Kentucky Pollutant Discharge Elimination System permit No. KY 0004049. This action prompted the US Department of Energy (DOE) to request a stay of certain limits contained in the permit. An AO is being negotiated between KDOW, the US Enrichment Corporation (USEC), and DOE that will require that several studies be conducted, including this stream temperature evaluation study, in an effort to establish permit limitations. All issues associated with this AO have been resolved, and the AO is currently being signed by all parties involved. The proposed effluent temperature limit is 89 F (31.7 C) as a mean monthly temperature. In the interim, temperatures are not to exceed 95 F (35 C) as a monthly mean or 100 F (37.8 C) as a daily maximum. This study includes detailed monitoring of instream temperatures, benthic macroinvertebrate communities, fish communities, and a laboratory study of thermal tolerances

  15. Increased Suicide Risk among Workers following Toxic Metal Exposure at the Paducah Gaseous Diffusion Plant From 1952 to 2003: A Cohort Study

    Directory of Open Access Journals (Sweden)

    LW Figgs

    2011-09-01

    Full Text Available Background: Suicide is a problem worldwide and occupation is an important risk factor. In the last decade, 55 200 deaths in the US were attributed to occupational risk factors. Objective: To determine if toxic metal exposure was associated with suicide risk among Paducah gaseous diffusion plant (PGDP workers. Methods: We assembled a cohort of 6820 nuclear industry workers employed from 1952 to 2003. A job-specific exposure matrix (JEM was used to determine metal exposure likelihood. Uranium exposure was also assessed by urinalysis. All suicide/self-injury International Classification for Disease (ICD codes were used to identify suicides. Standardized mortality ratios (SMR, odds ratios (OR, and hazard ratios (HR were used to estimate suicide risk. Results: PGDP suicide victims typically were younger white men. Within exposure likelihood categories, several suicide SMRs were typically elevated for several metals. Only beryllium exposure likelihood was associated with an increased HR. Uranium urine concentration was associated with an elevated suicide risk after stratification by urinalysis frequency. Conclusion: Suicide risk is associated with uranium exposure.

  16. Thermal Discharges from Paducah Gaseous Diffusion Plant Outfalls: Impacts on Stream Temperatures and Fauna of Little Bayou and Big Bayou Creeks

    International Nuclear Information System (INIS)

    Roy, W.K.

    1999-01-01

    The development of a biological monitoring plan for the receiving streams of the Paducah Gaseous Diffusion Plant (PGDP) began in the late 1980s, because of an Agreed Order (AO) issued in September 1987 by the Kentucky Division of Water (KDOW). Five years later, in September 1992, more stringent effluent limitations were imposed upon the PGDP operations when the KDOW reissued Kentucky Pollutant Discharge Elimination System permit No. KY 0004049. This action prompted the US Department of Energy (DOE) to request a stay of certain limits contained in the permit. An AO is being negotiated between KDOW, the United States Enrichment Corporation (USEC), and DOE that will require that several studies be conducted, including this stream temperature evaluation study, in an effort to establish permit limitations. All issues associated with this AO have been resolved, and the AO is currently being signed by all parties involved. The proposed effluent temperature limit is 89 F (31.7C) as a mean monthly temperature. In the interim, temperatures are not to exceed 95 F (35 C) as a monthly mean or 100 F (37.8 C) as a daily maximum. This study includes detailed monitoring of instream temperatures, benthic macroinvertebrate communities, fish communities, and a laboratory study of thermal tolerances

  17. Dispersion of UO2F2 aerosol and HF vapor in the operating floor during winter ventilation at the Paducah Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Kim, S.H.; Chen, N.C.J.; Taleyarkhan, R.P.; Keith, K.D.; Schmidt, R.W.; Carter, J.C.

    1996-01-01

    The gaseous diffusion process is currently employed at two plants in the US: the Paducah Gaseous Diffusion Plant and the Portsmouth Gaseous Diffusion Plant. As part of a facility-wide safety evaluation, a postulated design basis accident involving large line-rupture induced releases of uranium hexafluoride (UF 6 ) into the process building of a gaseous diffusion plant (GDP) is evaluated. When UF 6 is released into the atmosphere, it undergoes an exothermic chemical reaction with moisture (H 2 O) in the air to form vaporized hydrogen fluoride (HF) and aerosolized uranyl fluoride (UO 2 F 2 ). These reactants disperse in the process building and transport through the building ventilation system. The ventilation system draws outside air into the process building, distributes it evenly throughout the building, and discharges it to the atmosphere at an elevated temperature. Since air is recirculated from the cell floor area to the operating floor, issues concerning in-building worker safety and evacuation need to be addressed. Therefore, the objective of this study is to evaluate the transport of HF vapor and UO 2 F 2 aerosols throughout the operating floor area following B-line break accident in the cell floor area

  18. Thermal Discharges from Paducah Gaseous Diffusion Plant Outfalls: Impacts on Stream Temperatures and Fauna of Little Bayou and Big Bayou Creeks

    Energy Technology Data Exchange (ETDEWEB)

    Roy, W.K.

    1999-01-01

    The development of a biological monitoring plan for the receiving streams of the Paducah Gaseous Diffusion Plant (PGDP) began in the late 1980s, because of an Agreed Order (AO) issued in September 1987 by the Kentucky Division of Water (KDOW). Five years later, in September 1992, more stringent effluent limitations were imposed upon the PGDP operations when the KDOW reissued Kentucky Pollutant Discharge Elimination System permit No. KY 0004049. This action prompted the US Department of Energy (DOE) to request a stay of certain limits contained in the permit. An AO is being negotiated between KDOW, the United States Enrichment Corporation (USEC), and DOE that will require that several studies be conducted, including this stream temperature evaluation study, in an effort to establish permit limitations. All issues associated with this AO have been resolved, and the AO is currently being signed by all parties involved. The proposed effluent temperature limit is 89 F (31.7C) as a mean monthly temperature. In the interim, temperatures are not to exceed 95 F (35 C) as a monthly mean or 100 F (37.8 C) as a daily maximum. This study includes detailed monitoring of instream temperatures, benthic macroinvertebrate communities, fish communities, and a laboratory study of thermal tolerances.

  19. Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification

    Directory of Open Access Journals (Sweden)

    Jeliazko R. Jeliazkov

    2018-03-01

    Full Text Available Antibodies can rapidly evolve in specific response to antigens. Affinity maturation drives this evolution through cycles of mutation and selection leading to enhanced antibody specificity and affinity. Elucidating the biophysical mechanisms that underlie affinity maturation is fundamental to understanding B-cell immunity. An emergent hypothesis is that affinity maturation reduces the conformational flexibility of the antibody’s antigen-binding paratope to minimize entropic losses incurred upon binding. In recent years, computational and experimental approaches have tested this hypothesis on a small number of antibodies, often observing a decrease in the flexibility of the complementarity determining region (CDR loops that typically comprise the paratope and in particular the CDR-H3 loop, which contributes a plurality of antigen contacts. However, there were a few exceptions and previous studies were limited to a small handful of cases. Here, we determined the structural flexibility of the CDR-H3 loop for thousands of recent homology models of the human peripheral blood cell antibody repertoire using rigidity theory. We found no clear delineation in the flexibility of naïve and antigen-experienced antibodies. To account for possible sources of error, we additionally analyzed hundreds of human and mouse antibodies in the Protein Data Bank through both rigidity theory and B-factor analysis. By both metrics, we observed only a slight decrease in the CDR-H3 loop flexibility when comparing affinity matured antibodies to naïve antibodies, and the decrease was not as drastic as previously reported. Further analysis, incorporating molecular dynamics simulations, revealed a spectrum of changes in flexibility. Our results suggest that rigidification may be just one of many biophysical mechanisms for increasing affinity.

  20. Mediator Tail Module Is Required for Tac1-Activated CDR1 Expression and Azole Resistance in Candida albicans.

    Science.gov (United States)

    Liu, Zhongle; Myers, Lawrence C

    2017-11-01

    The human fungal pathogen Candida albicans develops drug resistance after long-term exposure to azole drugs in the treatment of chronic candidiasis. Gain-of-function (GOF) mutations in the transcription factor Tac1 and the consequent expression of its targets, drug efflux pumps Cdr1 and Cdr2, are a common mechanism by which C. albicans acquires fluconazole resistance. The mechanism by which GOF mutations hyperactivate Tac1 is currently unknown. Here, we define a transcriptional activation domain (TAD) at the C terminus of Tac1. GOF mutations within the Tac1 TAD, outside the context of full-length Tac1, generally do not enhance its absolute potential as a transcriptional activator. Negative regulation of the Tac1 TAD by the Tac1 middle region is necessary for the activating effect of GOF mutations or fluphenazine to be realized. We have found that full-length Tac1, when hyperactivated by xenobiotics or GOF mutations, facilitates the recruitment of the Mediator coactivator complex to the CDR1 promoter. Azole resistance and the activation of Tac1 target genes, such as CDR1 , are dependent on the Tac1 TAD and subunits of the Mediator tail module. The dependence of different Tac1 target promoters on the Mediator tail module, however, varies widely. Lastly, we show that hyperactivation of Tac1 is correlated with its Mediator-dependent phosphorylation, a potentially useful biomarker for Tac1 hyperactivation. The role of Mediator in events downstream of Tac1 hyperactivation in fluconazole-resistant clinical isolates is complex and provides opportunities and challenges for therapeutic intervention. Copyright © 2017 American Society for Microbiology.

  1. Overcoming the heterologous bias: An in vivo functional analysis of multidrug efflux transporter, CgCdr1p in matched pair clinical isolates of Candida glabrata

    International Nuclear Information System (INIS)

    Puri, Nidhi; Manoharlal, Raman; Sharma, Monika; Sanglard, Dominique; Prasad, Rajendra

    2011-01-01

    Research highlights: → First report to demonstrate an in vivo expression system of an ABC multidrug transporter CgCdr1p of C. glabrata. → First report on the structure and functional characterization of CgCdr1p. → Functional conservation of divergent but typical residues of CgCdr1p. → CgCdr1p elicits promiscuity towards substrates and has a large drug binding pocket with overlapping specificities. -- Abstract: We have taken advantage of the natural milieu of matched pair of azole sensitive (AS) and azole resistant (AR) clinical isolates of Candida glabrata for expressing its major ABC multidrug transporter, CgCdr1p for structure and functional analysis. This was accomplished by tagging a green fluorescent protein (GFP) downstream of ORF of CgCDR1 and integrating the resultant fusion protein at its native chromosomal locus in AS and AR backgrounds. The characterization confirmed that in comparison to AS isolate, CgCdr1p-GFP was over-expressed in AR isolates due to its hyperactive native promoter and the GFP tag did not affect its functionality in either construct. We observed that in addition to Rhodamine 6 G (R6G) and Fluconazole (FLC), a recently identified fluorescent substrate of multidrug transporters Nile Red (NR) could also be expelled by CgCdr1p. Competition assays with these substrates revealed the presence of overlapping multiple drug binding sites in CgCdr1p. Point mutations employing site directed mutagenesis confirmed that the role played by unique amino acid residues critical to ATP catalysis and localization of ABC drug transporter proteins are well conserved in C. glabrata as in other yeasts. This study demonstrates a first in vivo novel system where over-expression of GFP tagged MDR transporter protein can be driven by its own hyperactive promoter of AR isolates. Taken together, this in vivo system can be exploited for the structure and functional analysis of CgCdr1p and similar proteins wherein the arte-factual concerns encountered in using

  2. Overcoming the heterologous bias: An in vivo functional analysis of multidrug efflux transporter, CgCdr1p in matched pair clinical isolates of Candida glabrata

    Energy Technology Data Exchange (ETDEWEB)

    Puri, Nidhi; Manoharlal, Raman; Sharma, Monika [Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067 (India); Sanglard, Dominique [Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne (Switzerland); Prasad, Rajendra, E-mail: rp47jnu@gmail.com [Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067 (India)

    2011-01-07

    Research highlights: {yields} First report to demonstrate an in vivo expression system of an ABC multidrug transporter CgCdr1p of C. glabrata. {yields} First report on the structure and functional characterization of CgCdr1p. {yields} Functional conservation of divergent but typical residues of CgCdr1p. {yields} CgCdr1p elicits promiscuity towards substrates and has a large drug binding pocket with overlapping specificities. -- Abstract: We have taken advantage of the natural milieu of matched pair of azole sensitive (AS) and azole resistant (AR) clinical isolates of Candida glabrata for expressing its major ABC multidrug transporter, CgCdr1p for structure and functional analysis. This was accomplished by tagging a green fluorescent protein (GFP) downstream of ORF of CgCDR1 and integrating the resultant fusion protein at its native chromosomal locus in AS and AR backgrounds. The characterization confirmed that in comparison to AS isolate, CgCdr1p-GFP was over-expressed in AR isolates due to its hyperactive native promoter and the GFP tag did not affect its functionality in either construct. We observed that in addition to Rhodamine 6 G (R6G) and Fluconazole (FLC), a recently identified fluorescent substrate of multidrug transporters Nile Red (NR) could also be expelled by CgCdr1p. Competition assays with these substrates revealed the presence of overlapping multiple drug binding sites in CgCdr1p. Point mutations employing site directed mutagenesis confirmed that the role played by unique amino acid residues critical to ATP catalysis and localization of ABC drug transporter proteins are well conserved in C. glabrata as in other yeasts. This study demonstrates a first in vivo novel system where over-expression of GFP tagged MDR transporter protein can be driven by its own hyperactive promoter of AR isolates. Taken together, this in vivo system can be exploited for the structure and functional analysis of CgCdr1p and similar proteins wherein the arte-factual concerns

  3. An analysis of redactions in Canada's Common Drug Review Clinical Review Reports and how they relate to the patients' voice.

    Science.gov (United States)

    Soprovich, Allison; El Kurdi, Sylvia; Eurich, Dean T

    2017-09-11

    Canada's Common Drug Review (CDR) evaluates drug data from published and unpublished research, as well as input from patient groups, to recommend provincial coverage. Currently, the CDR process gives manufacturers the opportunity to redact information in the final publicly available report. Patients often have strong feelings regarding the efficacy, harms, health-related quality of life (HRQL), and cost associated with the drugs under review and their redacted data. Highlighting Canada's approach will hopefully build on the growing international concern regarding transparency of clinical study data. The purpose was to objectively examine and classify completed, publicly available CDR-Clinical Review Reports (CRR) for redactions, and compare them to the patients' reported interests as patient-centred outcomes. Two independent reviewers searched for and examined publicly available CDR-CRR from November 2013-September 2016 through the Canadian Agency for Drugs and Technologies in Health (CADTH) on-line database. Both reviewers separately classified the redactions and patient-reported interests into the following categories: efficacy, harms, HRQL and costs. All discrepancies were rectified by consensus involving a third reviewer. Fifty-two completed CDR-CRR were reviewed. 48 (92%) included patient-reported interests and 40 (77%) had redactions classified in the following categories: efficacy (75%), costs (48%), harms (38%), HRQL (23%). 89% of redactions were outcomes identified as patient-reported interests (69% efficacy, 42% harms, 36% cost, 33% HRQL). When examining drug characteristics, biological agents were statistically associated with increased odds of redactions with respect to either efficacy (OR 3.4, 95% CI 1.0 to 11.6) or harms (OR 3.5, 95% CI 1.02 to 12.4) compared with non-biological agents. Whether data from the CDR-CRR used in the decision-making should be fully disclosed to the public is controversial. Our findings suggest clinical data (efficacy

  4. The engineering design evolution of IFMIF: From CDR to EDA phase

    Energy Technology Data Exchange (ETDEWEB)

    Pérez, Mario, E-mail: mario.perez@ifmif.org

    2015-10-15

    Highlights: • Brief description of International Fusion Materials Irradiation Facility (IFMIF), its background and scope its Engineering Design and Validation Activities (EVEDA) phase. • Description and justification of the main design evolutions from previous phases; and in particular from the baseline described in the “Comprehensive Design Report” (CDR). - Abstract: The International Fusion Materials Irradiation Facility (IFMIF), presently in its Engineering Design and Engineering Validation Activities (EVEDA) phase, started in 2007 under the framework of the Broader Approach (BA) Agreement between Japanese Government and EURATOM. The mandate assigned was to develop an integrated engineering design of IFMIF together with accompanying sub-projects to validate the major technological challenges that included the construction of either full scale prototypes or cleverly devised scaled down facilities, which are essential to reliably face the construction of IFMIF on schedule and cost. The Engineering Design Activities were accomplished on-schedule with the release of its “Intermediate Engineering Design Report (IIEDR)” in June 2013 compliant with our mandate. This paper highlights the design improvements implemented from the previous Conceptual Design Phase.

  5. Intercomparison of PERSIANN-CDR and TRMM-3B42V7 precipitation estimates at monthly and daily time scales

    Science.gov (United States)

    Katiraie-Boroujerdy, Pari-Sima; Akbari Asanjan, Ata; Hsu, Kuo-lin; Sorooshian, Soroosh

    2017-09-01

    In the first part of this paper, monthly precipitation data from Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks-Climate Data Record (PERSIANN-CDR) and Tropical Rainfall Measuring Mission 3B42 algorithm Version 7 (TRMM-3B42V7) are evaluated over Iran using the Generalized Three-Cornered Hat (GTCH) method which is self-sufficient of reference data as input. Climate Data Unit (CRU) is added to the GTCH evaluations as an independent gauge-based dataset thus, the minimum requirement of three datasets for the model is satisfied. To ensure consistency of all datasets, the two satellite products were aggregated to 0.5° spatial resolution, which is the minimum resolution of CRU. The results show that the PERSIANN-CDR has higher Signal to Noise Ratio (SNR) than TRMM-3B42V7 for the monthly rainfall estimation, especially in the northern half of the country. All datasets showed low SNR in the mountainous area of southwestern Iran, as well as the arid parts in the southeast region of the country. Additionally, in order to evaluate the efficacy of PERSIANN-CDR and TRMM-3B42V7 in capturing extreme daily-precipitation amounts, an in-situ rain-gauge dataset collected by the Islamic Republic of the Iran Meteorological Organization (IRIMO) was employed. Given the sparsity of the rain gauges, only 0.25° pixels containing three or more gauges were used for this evaluation. There were 228 such pixels where daily and extreme rainfall from PERSIANN-CDR and TRMM-3B42V7 could be compared. However, TRMM-3B42V7 overestimates most of the intensity indices (correlation coefficients; R between 0.7648-0.8311, Root Mean Square Error; RMSE between 3.29mm/day-21.2mm/5day); PERSIANN-CDR underestimates these extremes (R between 0.6349-0.7791 and RMSE between 3.59mm/day-30.56mm/5day). Both satellite products show higher correlation coefficients and lower RMSEs for the annual mean of consecutive dry spells than wet spells. The results show that TRMM-3B42V7

  6. A Climate-Data Record (CDR) of the "Clear Sky" Surface Temperature of the Greenland Ice Sheet

    Science.gov (United States)

    Hall, Dorothy K.; Comiso, J. C.; DiGirolamo, N. E.; Shuman, C. A.

    2011-01-01

    To quantify the ice-surface temperature (IST) we are developing a climate-data record (CDR) of monthly IST of the Greenland ice sheet, from 1982 to the present using Advanced Very High Resolution Radiometer (AVHRR) and Moderate-Resolution Imaging Spectroradiometer (MODIS) data at 5-km resolution. "Clear-sky" surface temperature increases have been measured from the early 1980s to the early 2000s in the Arctic using AVHRR data, showing increases ranging from 0.57-0.02 (Wang and Key, 2005) to 0.72 0.10 deg C per decade (Comiso, 2006). Arctic warming has implications for ice-sheet mass balance because much of the periphery of the ice sheet is near 0 deg C in the melt season and is thus vulnerable to more extensive melting (Hanna et al., 2008). The algorithm used for this work has a long history of measuring IST in the Arctic with AVHRR (Key and Haefliger, 1992). The data are currently available from 1981 to 2004 in the AVHRR Polar Pathfinder (APP) dataset (Fowler et al., 2000). J. Key1NOAA modified the AVHRR algorithm for use with MODIS (Hall et al., 2004). The MODIS algorithm is now being processed over Greenland. Issues being addressed in the production of the CDR are: time-series bias caused by cloud cover, and cross-calibration between AVHRR and MODIS instruments. Because of uncertainties, time series of satellite ISTs do not necessarily correspond with actual surface temperatures. The CDR will be validated by comparing results with in-situ (see Koenig and Hall, in press) and automatic-weather station data (e.g., Shuman et al., 2001).

  7. Project W-519 CDR supplement: Raw water and electrical services for privatization contractor, AP tank farm operations

    International Nuclear Information System (INIS)

    Parazin, R.J.

    1998-01-01

    This supplement to the Project W-519 Conceptual Design will identify a means to provide RW and Electrical services to serve the needs of the TWRS Privatization Contractor (PC) at AP Tank Farm as directed by DOE-RL. The RW will serve the fire suppression and untreated process water requirements for the PC. The purpose of this CDR supplement is to identify Raw Water (RW) and Electrical service line routes to the TWRS Privatization Contractor (PC) feed delivery tanks, AP-106 and/or AP-108, and establish associated cost impacts to the Project W-519 baseline

  8. Stakeholders' opinions on the implementation of Child Death Review in the Netherlands

    NARCIS (Netherlands)

    Gijzen, S.; Hoir, M.P. L; Boere-Boonekamp, M.M.; Need, A.

    2016-01-01

    Background The death of a child is an enormous tragedy for both the family and others involved. A child’s death appeals to everyone’s responsibility to take measures to prevent similar deaths in the future. Child Death Review (CDR) is an interagency approach in which a child’s death is

  9. Stakeholders’ opinions on the implementation of Child Death Review in the Netherlands

    NARCIS (Netherlands)

    Knoeff-Gijzen, Sandra; L'Hoir, Monique P.; Boere-Boonekamp, Magdalena M.; Need, Ariana

    2016-01-01

    Background The death of a child is an enormous tragedy for both the family and others involved. A child’s death appeals to everyone’s responsibility to take measures to prevent similar deaths in the future. Child Death Review (CDR) is an interagency approach in which a child’s death is

  10. Classification of maltreatment-related mortality by Child Death Review teams: How reliable are they?

    Science.gov (United States)

    Parrish, Jared W; Schnitzer, Patricia G; Lanier, Paul; Shanahan, Meghan E; Daniels, Julie L; Marshall, Stephen W

    2017-05-01

    Accurate estimation of the incidence of maltreatment-related child mortality depends on reliable child fatality review. We examined the inter-rater reliability of maltreatment designation for two Alaskan Child Death Review (CDR) panels. Two different multidisciplinary CDR panels each reviewed a series of 101 infant and child deaths (ages 0-4 years) in Alaska. Both panels independently reviewed identical medical, autopsy, law enforcement, child welfare, and administrative records for each death utilizing the same maltreatment criteria. Percent agreement for maltreatment was 64.7% with a weighted Kappa of 0.61 (95% CI 0.51, 0.70). Across maltreatment subtypes, agreement was highest for abuse (69.3%) and lowest for negligence (60.4%). Discordance was higher if the mother was unmarried or a smoker, if residence was rural, or if there was a family history of child protective services report(s). Incidence estimates did not depend on which panel's data were used. There is substantial room for improvement in the reliability of CDR panel assessment of maltreatment related mortality. Standardized decision guidance for CDR panels may improve the reliability of their data. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Procedures in child deaths in The Netherlands: a comparison with child death review

    NARCIS (Netherlands)

    Gijzen, S.; Petter, J.; L'Hoir, M.P.; Boere-Boonekamp, M.M.; Need, A.

    2017-01-01

    Aim: Child Death Review (CDR) is a method in which every child death is systematically and multidisciplinary examined to (1) improve death statistics, (2) identify factors that give direction for prevention, (3) translate the results into possible interventions, and (4) support families. The aim of

  12. Procedures in child deaths in The Netherlands : a comparison with child death review

    NARCIS (Netherlands)

    Knoeff-Gijzen, Sandra; Petter, Jessica; L'Hoir, Monique P.; Boere-Boonekamp, Magdalena M.; Need, Ariana

    2017-01-01

    Aim Child Death Review (CDR) is a method in which every child death is systematically and multidisciplinary examined to (1) improve death statistics, (2) identify factors that give direction for prevention, (3) translate the results into possible interventions, and (4) support families. The aim of

  13. ENZYME ACTIVITY PROBE AND GEOCHEMICAL ASSESSMENT FOR POTENTIAL AEROBIC COMETABOLISM OF TRICHLOROETHENE IN GROUNDWATER OF THE NORTHWEST PLUME, PADUCAH GASEOUS DIFFUSION PLANT, KENTUCKY

    International Nuclear Information System (INIS)

    Looney, B; M. Hope Lee, M; S. K. Hampson, S

    2008-01-01

    The overarching objective of the Paducah Gaseous Diffusion Plant (PGDP) enzyme activity probe (EAP) effort is to determine if aerobic cometabolism is contributing to the attenuation of trichloroethene (TCE) and other chlorinated solvents in the contaminated groundwater beneath PGDP. The site-specific objective for the EAP assessment is to identify if key metabolic pathways are present and expressed in the microbial community--namely the pathways that are responsible for degradation of methane and aromatic (e.g. toluene, benzene, phenol) substrates. The enzymes produced to degrade methane and aromatic compounds also break down TCE through a process known as cometabolism. EAPs directly measure if methane and/or aromatic enzyme production pathways are operating and, for the aromatic pathways, provide an estimate of the number of active organisms in the sampled groundwater. This study in the groundwater plumes at PGDP is a major part of a larger scientific effort being conducted by Interstate Technology and Regulatory Council (ITRC), U.S. Department of Energy (DOE) Office of Environmental Management (EM), Savannah River National Laboratory (SRNL), and North Wind Inc. in which EAPs are being applied to contaminated groundwater from diverse hydrogeologic and plume settings throughout the U.S. to help standardize their application as well as their interpretation. While EAP data provide key information to support the site specific objective for PGDP, several additional lines of evidence are being evaluated to increase confidence in the determination of the occurrence of biodegradation and the rate and sustainability of aerobic cometabolism. These complementary efforts include: (1) Examination of plume flowpaths and comparison of TCE behavior to 'conservative' tracers in the plume (e.g., 99 Tc); (2) Evaluation of geochemical conditions throughout the plume; and (3) Evaluation of stable isotopes in the contaminants and their daughter products throughout the plume. If the

  14. Aplicação da versão brasileira da escala de avaliação clínica da demência (Clinical Dementia Rating - CDR em amostras de pacientes com demência Application of the Brazilian version of the CDR scale in samples of dementia patients

    Directory of Open Access Journals (Sweden)

    Alberto Luiz Grigoli Maia

    2006-06-01

    Full Text Available OBJETIVO: Avaliar a concordância da escala CDR com critérios diagnósticos e mini exame do estado mental (MEEM, e correlação com escala de Blessed, numa amostra de pacientes do sul do Brasil. MÉTODO: A escala foi avaliada em 269 pacientes com doença de Alzheimer (DA, demência vascular e demência questionável num desenho transversal. Os critérios do NINCDS-ADRDA para provável DA e NINDS-AIREN para provável demência vascular foram os padrões-ouro. O MEEM, a escala Blessed para gravidade da demência, o escore isquêmico de Hachinski, e uma bateria de testes cognitivos também foram aplicados. RESULTADOS: A concordância com o padrão-ouro foi boa (kappa=0,73, e com o MEEM em categorias foi moderada (kappa= 0,53. Observou-se correlação significativa da escala CDR com Blessed (r=0,96; p=0,001. Não se observou diferença de escolaridade ou de idade entre as categorias da escala CDR. CONCLUSÃO: A concordância da CDR foi boa para os critérios diagnósticos e moderada para o MEEM. A escala mostrou validade de construto para gravidade de demência. Não se observou impacto da escolaridade sobre este instrumento.OBJECTIVE: The objective of the study was the analysis of agreement between the CDR scale with diagnostic criteria and mini mental state examination (MMSE, as well as correlation with Blessed scale, in a sample of Southern Brazilian patients. METHOD: The CDR scale was cross-sectionaly evaluated in 269 dementia patients Alzheimer’s disease (AD vascular dementia, and questionable. The NINCDS-ADRDA criteria for probable AD and the NINDS-AIREN for probable vascular dementia were the gold standard. The MMSE, the Blessed scale, the Hachinski ischemic score, and a battery of cognitive tests were also applied. RESULTS: The agreement to gold standard was good (kappa=0.73, while to MMSE categorized was moderate (kappa=0.53. A significant correlation with the Blessed scale (r=0.96; p=0.001 was observed. Education and age were similar

  15. The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface

    DEFF Research Database (Denmark)

    Rybtke, Morten; Berthelsen, Jens; Yang, Liang

    2015-01-01

    Pseudomonas aeruginosa is a clinically relevant species involved in biofilm-based chronic infections. We provide evidence that the P. aeruginosa LapG protein functions as a periplasmic protease that can cleave the protein adhesin CdrA off the cell surface, and thereby plays a role in biofilm...... formation and biofilm dispersal. The P. aeruginosa LapG protein is shown to be a functional homolog of the Pseudomonas putida LapG protein which has previously been shown to function as a periplasmic protease that targets the surface adhesin LapA. Transposon mutagenesis and characterization of defined...... and whole-cell protein fractions showed that CdrA was retained in the whole-cell protein fraction when LapG was absent, whereas it was found in the culture supernatant when LapG was present. The finding that CdrA is a target of LapG in P. aeruginosa is surprising because CdrA has no homology to LapA....

  16. Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

    Science.gov (United States)

    Dunn, Steven M.; Rizkallah, Pierre J.; Baston, Emma; Mahon, Tara; Cameron, Brian; Moysey, Ruth; Gao, Feng; Sami, Malkit; Boulter, Jonathan; Li, Yi; Jakobsen, Bent K.

    2006-01-01

    The mammalian α/β T cell receptor (TCR) repertoire plays a pivotal role in adaptive immunity by recognizing short, processed, peptide antigens bound in the context of a highly diverse family of cell-surface major histocompatibility complexes (pMHCs). Despite the extensive TCR–MHC interaction surface, peptide-independent cross-reactivity of native TCRs is generally avoided through cell-mediated selection of molecules with low inherent affinity for MHC. Here we show that, contrary to expectations, the germ line-encoded complementarity determining regions (CDRs) of human TCRs, namely the CDR2s, which appear to contact only the MHC surface and not the bound peptide, can be engineered to yield soluble low nanomolar affinity ligands that retain a surprisingly high degree of specificity for the cognate pMHC target. Structural investigation of one such CDR2 mutant implicates shape complementarity of the mutant CDR2 contact interfaces as being a key determinant of the increased affinity. Our results suggest that manipulation of germ line CDR2 loops may provide a useful route to the production of high-affinity TCRs with therapeutic and diagnostic potential. PMID:16600963

  17. Systemic Lupus Erythematosus: Molecular Mimicry between Anti-dsDNA CDR3 Idiotype, Microbial and Self Peptides-As Antigens for Th Cells.

    Science.gov (United States)

    Aas-Hanssen, Kristin; Thompson, Keith M; Bogen, Bjarne; Munthe, Ludvig A

    2015-01-01

    Systemic lupus erythematosus (SLE) is marked by a T helper (Th) cell-dependent B cell hyperresponsiveness, with frequent germinal center reactions, and gammaglobulinemia. A feature of SLE is the finding of IgG autoantibodies specific for dsDNA. The specificity of the Th cells that drive the expansion of anti-dsDNA B cells is unresolved. However, anti-microbial, anti-histone, and anti-idiotype Th cell responses have been hypothesized to play a role. It has been entirely unclear if these seemingly disparate Th cell responses and hypotheses could be related or unified. Here, we describe that H chain CDR3 idiotypes from IgG(+) B cells of lupus mice have sequence similarities with both microbial and self peptides. Matched sequences were more frequent within the mutated CDR3 repertoire and when sequences were derived from lupus mice with expanded anti-dsDNA B cells. Analyses of histone sequences showed that particular histone peptides were similar to VDJ junctions. Moreover, lupus mice had Th cell responses toward histone peptides similar to anti-dsDNA CDR3 sequences. The results suggest that Th cells in lupus may have multiple cross-reactive specificities linked to the IgVH CDR3 Id-peptide sequences as well as similar DNA-associated protein motifs.

  18. The T-cell receptor beta chain CDR3 region of BV8S1/BJ1S5 transcripts in type 1 diabetes.

    Science.gov (United States)

    Naserke, H E; Durinovic-Bellò, I; Seidel, D; Ziegler, A G

    1996-01-01

    We recently described the T-cell receptor (TCR) beta chain CDR3 motif S-SDRLG-NQPQH (BV8S1-BJ1S5) in an islet-specific T-cell clone (K2.12) from a type 1 diabetic patient (AS). A similar motif (RLGNQ) was also reported in a T-cell clone of non-obese diabetic (NOD) mice by others. In order to determine the frequency of our motif in selected and unselected T-cell populations, we cloned and sequenced the CDR3 region of BV8S1-BJ1S5 transcripts. These transcripts were derived from unstimulated peripheral blood T lymphocytes from two type 1 diabetic patients (AS and FS) and their non-diabetic sibling (WS), as well as from an islet-specific T-cell line of one of the patients. In addition, we compared the structure and composition of the CDR3 region in BV8S1-BJ1S5 transcripts from peripheral blood T cells between the patients and their non-diabetic sibling (>50 sequences each). We found that 30% of the islet-specific T-cell line cDNA clones expressed the entire sequence-motif, whereas it was absent in the clones of unstimulated peripheral blood T cells from both patients and their non-diabetic sibling. The average length of the CDR3 region was shorter in the patients (mean AS 9.9, FS 9.9, versus WS 10.7, p = 0.0037) and the number of inserted nucleotides in N nucleotide addition at the DJ-junction lower (mean AS 3.5, FS 3. 2, versus WS 5.2, P = diabetic sibling. Moreover, the pattern of amino acid usage in the CDR3 region was dissimilar at positions 5 and 6, where polar amino acids predominated in both diabetic siblings. In contrast, basic amino acids are preferentially used at position 5 in the clones of the non-diabetic sibling. These data provide information on the general structure of the TCR(BV8S1-BJ1S5) CDR3 region in type 1 diabetes and may indicate differences in the amino and nucleic acid composition of the TCR beta chain CDR3 region between two type 1 diabetic patients and their non-diabetic sibling.

  19. Effect of the herbal formulation Jianpijiedu on the TCRVβCDR3 repertoire in rats with hepatocellular carcinoma and subjected to food restriction combined with laxative.

    Science.gov (United States)

    Sun, Baoguo; Meng, Jun; Xiang, Ting; Zhang, Lei; Deng, Liuxiang; Chen, Yan; Luo, Haoxuan; Yang, Zhangbin; Chen, Zexiong; Zhang, Shijun

    2016-03-01

    The aim of this study was to investigate the effects of the Chinese herbal formulation Jianpijiedu (JPJD) in a rat model of orthotopic hepatocellular carcinoma (OHC). The tumor-bearing rats underwent food restriction combined with laxative (FRL) treatment in order to model the nutritional and digestive symptoms of patients with hepatocellular carcinoma. In addition, the study aimed to elucidate the effect of JPJD on the T cell receptor Vβ-chain complementarity-determining region 3 (TCRVβCDR3) repertoire and the underlying mechanism. The FRL rat model was established by alternate-day food restriction and the oral administration of Glauber's salt (sodium sulfate), based on which the OHC model was then established. Subsequently, the FRL-OHC induced animals received JPJD or thymopentin-5 (TP5) for 17 days. Differences in the TCRVβCDR3 repertoire in the rat thymus, liver and hepatocellular carcinoma tissues were analyzed by polymerase chain reaction. Compared with the FRL-OHC model animals without any treatment, those treated with JPJD exhibited significantly inhibited hepatocellular carcinoma growth (PSimpsons diversity index (Ds) values and the quasi-Gaussian distribution rate of the TCRVβCDR3 repertoire in the thymus, liver and hepatocellular carcinoma tissues. However, no anti-hepatoma effects were evident in the rats treated with TP5. In addition, TP5 increased the Ds values and the quasi-Gaussian distribution rate of the TCRVβCDR3 repertoire in hepatocellular carcinoma tissues compared with those in the JPJD-treated group. The anti-hepatoma effects of JPJD in FRL-OHC-induced animals may be due to the promotion of the Ds values of the TCRVβCDR3 repertoire.

  20. Integration technique of digital I and C replacement and its Critical Digital Review procedure

    International Nuclear Information System (INIS)

    Huang, Hui-Wen; Yang, Wen-Long

    2013-01-01

    Highlights: ► A digital I and C replacement integration technique have been developed. ► Establishment of Nuclear Power Plant Digital Replacement Integration Guideline. ► Preliminary Investigation on I and C System Digitalization. ► Evaluation on I and C System Digitalization. ► Establishment of I and C System Digitalization Architectures. -- Abstract: Institute of Nuclear Energy Research (INER) developed a digital Instrumentation and Control (I and C) replacement integration technique on the basis of requirement of the three existing nuclear power plants (NPPs), which are Chin–Shan (CS) NPP, Kuo–Sheng (KS) NPP, and Maanshan (MS) NPP, in Taiwan, and also developed the related Critical Digital Review (CDR) procedure. The digital I and C replacement integration technique includes: (1) Establishment of Nuclear Power Plant Digital Replacement Integration Guideline, (2) Preliminary Investigation on I and C System Digitalization, (3) Evaluation on I and C System Digitalization, and (4) Establishment of I and C System Digitalization Architectures. These works can be a reference for performing I and C system digital replacement integration of the three existing NPPs of Taiwan Power Company (TPC). A CDR is the review for a critical system digital I and C replacement. The major reference of this procedure is EPRI TR-1011710 (2005) “Handbook for Evaluating Critical Digital Equipment and Systems” which was published by the Electric Power Research Institute (EPRI). With this document, INER developed a TPC-specific CDR procedure. Currently, CDR becomes one of the policies for digital I and C replacement in TPC. The contents of this CDR procedure include: Scope, Responsibility, Operation Procedure, Operation Flow Chart, CDR review items. The CDR review items include the comparison of the design change, Software Verification and Validation (SV and V), Failure Mode and Effects Analysis (FMEA), Evaluation of Diversity and Defense-in-depth (D3), Evaluation of

  1. Comparison of GPM IMERG, TMPA 3B42 and PERSIANN-CDR satellite precipitation products over Malaysia

    Science.gov (United States)

    Tan, Mou Leong; Santo, Harrif

    2018-04-01

    The launch of the Global Precipitation Measurement (GPM) mission has prompted the assessment of the newly released satellite precipitation products (SPPs) in different parts of the world. This study performed an initial comparison of three GPM IMERG products (IMERG_E, IMERG_L and IMERG_F) with its predecessor, the TMPA 3B42 and 3B42RT products, and a long-term PERSIANN-CDR product over Malaysia. The performance of six SPPs was evaluated using 501 precipitation gauges from 12 March 2014 to 29 February 2016. The annual, seasonal, monthly and daily precipitation measurements were validated using three widely used statistical metrics (CC, RMSE and RB). The precipitation detection capability (POD, FAR and CSI), probability density function (PDF) and the 2014-2015 flood event analysis were also considered in this assessment. The results show that all the SPPs perform well in annual and monthly precipitation measurements. The spatial variability of the total annual precipitation in 2015 is well captured by all six SPPs, with high precipitation amount in southern East Malaysia, and low precipitation amount in the middle part of Peninsular Malaysia. In contrast, all the SPPs show moderate correlation at daily precipitation estimations, with better performance during the northeast monsoon season. The performance of all the SPPs is better in eastern Peninsular Malaysia, but poorer in northern Peninsular Malaysia. All the SPPs have good precipitation detection ability, except the PERSIANN-CDR. All the SPPs underestimate the light (0-1 mm/day) and violent (> 50 mm/day) precipitation classes, but overestimate moderate and heavy (1-50 mm/day) precipitation classes. The IMERG is shown to have a better capability in detecting light precipitation (0-1 mm/day) compared to the other SPPs. The PERSIANN-CDR has the worst performance in capturing all the precipitation classes, with significant underestimation of light precipitation (0-1 mm/day) class and overestimation of moderate and

  2. Efecto e influencia de los certificados de depositos reprogramados (cdr`s) durante 1999-2000 en el mercado ecuatoriano

    OpenAIRE

    Leon Cercado, Alejandra; Triana Villanueva, Milton

    2009-01-01

    Por ser los certificados de depósitos (CDR) instrumentos financieros que surgieron como respuesta a la crisis que experimentó la economía ecuatoriana durante el año 1999, al producirse un alza incontrolable de la cotización del sucre respecto del dólar que desembocó en un nuevo modelo de dolarización y en cuyo proceso también la banca en general se vió afectada con el cierre de varios bancos que presentaban problemas de íliquidez y mala administración de sus recursos, el análisis efectuado de...

  3. In vitro radiographic determination of distances from working length files to root ends comparing Kodak RVG 6000, Schick CDR, and Kodak insight film.

    Science.gov (United States)

    Radel, Robert T; Goodell, Gary G; McClanahan, Scott B; Cohen, Mark E

    2006-06-01

    Previous studies suggest that digital and film-based radiography are similar for endodontic measurements. This study compared the accuracy and acceptability of measured distances from the tips of size #10 and #15 files to molar root apices in cadaver jaw sections using the newly developed Kodak RVG 6000, and the Schick CDR digital systems to digitized Kodak film. Standardized images were taken of files placed 0.5 to 1.5 mm short of true radiographic lengths. Images were imported into Adobe PhotoShop 7.0, thereby blinding observers who measured distances from files to root apices and assessed images for clarity (acceptability). Repeated measures ANOVA and Tukey-Kramer post hoc tests demonstrated that Kodak RVG 6000 images with enhanced contrast produced significantly less measurement error than unenhanced contrast Schick CDR images (p Kodak RVG 6000 system provided the best overall images.

  4. ABC transporter Cdr1p harbors charged residues in the intracellular loop and nucleotide-binding domain critical for protein trafficking and drug resistance.

    Science.gov (United States)

    Shah, Abdul Haseeb; Banerjee, Atanu; Rawal, Manpreet Kaur; Saxena, Ajay Kumar; Mondal, Alok Kumar; Prasad, Rajendra

    2015-08-01

    The ABC transporter Cdr1 protein of Candida albicans, which plays a major role in antifungal resistance, has two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The 12 transmembrane helices of TMDs that are interconnected by extracellular and intracellular loops (ICLs) mainly harbor substrate recognition sites where drugs bind while cytoplasmic NBDs hydrolyze ATP which powers drug efflux. The coupling of ATP hydrolysis to drug transport requires proper communication between NBDs and TMDs typically accomplished by ICLs. This study examines the role of cytoplasmic ICLs of Cdr1p by rationally predicting the critical residues on the basis of their interatomic distances. Among nine pairs that fall within a proximity of trafficking. These results point to a new role for ICL/NBD interacting residues in PDR ABC transporters in protein folding and trafficking. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  5. T-cell receptor Vbeta CDR3 oligoclonality frequently occurs in childhood refractory cytopenia (MDS-RC) and severe aplastic anemia

    DEFF Research Database (Denmark)

    Vries, A.C. de; Langerak, A.W.; Verhaaf, B.

    2008-01-01

    (Very) severe acquired aplastic anemia ((v)SAA) and myelodysplastic syndrome (MDS) are rare diseases in childhood. (V)SAA is a bone marrow (BM) failure syndrome characterized by immune-mediated destruction of hematopoietic progenitors. MDS is a malignant clonal stem cell disorder, of which...... the hypoplastic variant is, in case of absence of a cytogenetic clone, difficult to separate from (v)SAA. Recently, studies provided a molecular signature of autoimmunity in adult (v)SAA, by showing oligoclonality based on the length of the TCR Vbeta CDR3 region. We investigated retrospectively the frequency...... and the discriminative value of TCR Vbeta CDR3 oligoclonality in pediatric (v)SAA and MDS patients. Peripheral blood (PB) and/or BM mononuclear cell samples of pediatric patients with (v)SAA (n=38), refractory cytopenia (MDS-RC) (n=28) and 18 controls were analysed via TCR Vbeta heteroduplex PCR analysis of extracted...

  6. SU-E-P-55: The Reaserch of Cervical Cancer Delivered with Constant Dose Rate and Gantry Speed Arc Therapy(CDR-CAS-IMAT) On Conventional Linac

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, R; Bai, W; Chi, Z; Gao, C; Xiaomei, F [The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei (China); Gao, Y [Hebei General Hospital, Shijiazhuang, Hebei (China)

    2015-06-15

    Purpose: Postoperative cervical cancer patients with large target volume and the target shape is concave, treatmented with static intensity-modulated radiotherapy (IMRT) is time consuming. The purpose of this study is to investigate using constant dose rate and gantry speed arc therapy(CDR-CAS-IMAT) on conventional linear accelrator, by comparing with the IMRT technology to evaluate the performance of CDR-CAS-IMAT on postoperative cervical cancer patients. Methods: 18 cervical cancer patients treated with IMRT on Varian 23IX were replanted using CDR-CAS-IMAT. The plans were generated on Oncentra v4.1 planning system, PTV was prescribed to 50.4 Gy in 28 fractions. Plans were evaluated based on the ability to meet the dose volume histogram. The homogeneity index (HI), conformity index (CI) of target volume, the dose of organs at risk, radiation delivery time and monitor units were also compared. SPSS 19.0 software paired T-test analysis was carried out on the two sets of data. Results: Compared with the IMRT plans PTV’s CI (t= 3.85, P =0.001), CTV’s CI, HI, D90, D95, D98, V95, V98, V100 (t=4.21, −3.18, 2.13, 4.65, 7.79, 2.29, 6.00, 2.13, p=0.001, 0.005, 0.049, 0.000, 0.000, 0.035, 0.000, 0.049), and cord D2 and rectum V40 (t=−2.65, −2.47, p= P =0.017, 0.025), and treatment time and MU (t=−36.0, −6.26, P =0.000, 0.000) were better than that of IMRT group. But the IMRT plans in terms of decreasing bladder V50, bowel V30 (t=2.14, 3.00, P =0.048, 0.008) and low dose irradiation volume were superior to that of CDR-CAS-IMAT plans. There were no significant differences in other statistical index. Conclusion: Cervical cancer patients with CDR-CAS-IMAT on Varian Clinical 23IX can get equivalent or superior dose distribution compared with the IMRT technology. IMAT have much less treatment time and MU can reduce the uncertainty factor and patient discomfort in treatment. This work was supported by the Medical Science Foundation of the health department of Hebei

  7. INCIDENCE.CDR NEW 1.CDR

    African Journals Online (AJOL)

    KEY WORDS: Commercial ... are at far greater risk than the drivers and passengers of. 4 ... Despite the clear evidence of higher ... recall, thus the incidence of accidents is likely to be ..... complete picture of the pattern of injuries which occur.

  8. Iodine-131-labelled CDR grafted monoclonal antibody huA33 metastatic colorectal carcinoma: A case study

    International Nuclear Information System (INIS)

    Thomas, D.L.; Lee, F.T.; Scott, A.M.

    1997-01-01

    Full text: A 58-year-old woman was diagnosed with metastatic colorectal carcinoma two years after initial surgery for sigmoid carcinoma. As part of the staging work-up she was initially referred for a 18 F-FDG PET scan at the PET Centre. FDG PET scans of the abdomen and pelvis demonstrated multiple hepatic lesions, but there was no evidence of disease outside the liver. On the basis of extensive hepatic disease, the patient was scheduled for a laparotomy for insertion of an hepatic artery catheter for chemotherapy. In view of her clinical presentation, the patient was eligible for a Phase 1 trial with 131 l-labelled huA33, and agreed to participate. HuA33 is a humanised CDR-grafted recombinant monoclonal antibody directed against an antigen found on >95 per cent of all colorectal carcinomas, and on small bowel and colonic mucosa. The phase 1 trial is a protein dose escalation study designed to examine the biodistribution, pharmacokinetics, dosimetry and safety profile of huA33, and sequential gamma camera images of the whole body were obtained daily until seven days post infusion. SPECT images were obtained on day 6. Excellent localisation of 131 l-huA33 was seen in hepatic lesions. Calculation of whole body retention and tumour uptake was performed, and pharmacokinetic analysis also undertaken. Biopsies of tumour obtained at surgery were used to quantitate tumour uptake and cellular trafficking of 131 l-huA33. On the basis of this phase 1 study, future therapeutic trials of 131 I-huA33 are planned

  9. Assessing the state of the art in biomedical relation extraction: overview of the BioCreative V chemical-disease relation (CDR) task.

    Science.gov (United States)

    Wei, Chih-Hsuan; Peng, Yifan; Leaman, Robert; Davis, Allan Peter; Mattingly, Carolyn J; Li, Jiao; Wiegers, Thomas C; Lu, Zhiyong

    2016-01-01

    Manually curating chemicals, diseases and their relationships is significantly important to biomedical research, but it is plagued by its high cost and the rapid growth of the biomedical literature. In recent years, there has been a growing interest in developing computational approaches for automatic chemical-disease relation (CDR) extraction. Despite these attempts, the lack of a comprehensive benchmarking dataset has limited the comparison of different techniques in order to assess and advance the current state-of-the-art. To this end, we organized a challenge task through BioCreative V to automatically extract CDRs from the literature. We designed two challenge tasks: disease named entity recognition (DNER) and chemical-induced disease (CID) relation extraction. To assist system development and assessment, we created a large annotated text corpus that consisted of human annotations of chemicals, diseases and their interactions from 1500 PubMed articles. 34 teams worldwide participated in the CDR task: 16 (DNER) and 18 (CID). The best systems achieved an F-score of 86.46% for the DNER task--a result that approaches the human inter-annotator agreement (0.8875)--and an F-score of 57.03% for the CID task, the highest results ever reported for such tasks. When combining team results via machine learning, the ensemble system was able to further improve over the best team results by achieving 88.89% and 62.80% in F-score for the DNER and CID task, respectively. Additionally, another novel aspect of our evaluation is to test each participating system's ability to return real-time results: the average response time for each team's DNER and CID web service systems were 5.6 and 9.3 s, respectively. Most teams used hybrid systems for their submissions based on machining learning. Given the level of participation and results, we found our task to be successful in engaging the text-mining research community, producing a large annotated corpus and improving the results of

  10. Reviews

    Science.gov (United States)

    2002-11-01

    CD-ROM REVIEW (551) Essential Physics BOOK REVIEWS (551) Collins Advanced Science: Physics, 2nd edition Quarks, Leptons and the Big Bang, 2nd edition Do Brilliantly: A2 Physics IGCSE Physics Geophysics in the UK Synoptic Skills in Advanced Physics Flash! The hunt for the biggest explosions in the universe Materials Maths for Advanced Physics

  11. Gamma radiological surveys of the Oak Ridge Reservation, Paducah Gaseous Diffusion Plant, and Portsmouth Gaseous Diffusion Plant, 1990-1993, and overview of data processing and analysis by the Environmental Restoration Remote Sensing Program, Fiscal Year 1995

    International Nuclear Information System (INIS)

    Smyre, J.L.; Moll, B.W.; King, A.L.

    1996-06-01

    Three gamma radiological surveys have been conducted under auspices of the ER Remote Sensing Program: (1) Oak Ridge Reservation (ORR) (1992), (2) Clinch River (1992), and (3) Portsmouth Gaseous Diffusion Plant (PORTS) (1993). In addition, the Remote Sensing Program has acquired the results of earlier surveys at Paducah Gaseous Diffusion Plant (PGDP) (1990) and PORTS (1990). These radiological surveys provide data for characterization and long-term monitoring of U.S. Department of Energy (DOE) contamination areas since many of the radioactive materials processed or handled on the ORR, PGDP, and PORTS are direct gamma radiation emitters or have gamma emitting daughter radionuclides. High resolution airborne gamma radiation surveys require a helicopter outfitted with one or two detector pods, a computer-based data acquisition system, and an accurate navigational positioning system for relating collected data to ground location. Sensors measure the ground-level gamma energy spectrum in the 38 to 3,026 KeV range. Analysis can provide gamma emission strength in counts per second for either gross or total man-made gamma emissions. Gross count gamma radiation includes natural background radiation from terrestrial sources (radionuclides present in small amounts in the earth's soil and bedrock), from radon gas, and from cosmic rays from outer space as well as radiation from man-made radionuclides. Man-made count gamma data include only the portion of the gross count that can be directly attributed to gamma rays from man-made radionuclides. Interpretation of the gamma energy spectra can make possible the determination of which specific radioisotopes contribute to the observed man-made gamma radiation, either as direct or as indirect (i.e., daughter) gamma energy from specific radionuclides (e.g., cesium-137, cobalt-60, uranium-238)

  12. Reviews.

    Science.gov (United States)

    Journal of Chemical Education, 1987

    1987-01-01

    Provides a review of both the Apple and IBM versions of ENZPACK, a software package which is designed to assist in the teaching of enzyme kinetics in courses where this topic is treated in some depth. (TW)

  13. Review

    Indian Academy of Sciences (India)

    2012-03-29

    Mar 29, 2012 ... The present review documents an overview of speciation mediated through behavioural ...... The Drosophila model (New York: Oxford University Press) .... second part of his big species book written from 1856–1858. (New ...

  14. Validity, reliability, and feasibility of clinical staging scales in dementia: a systematic review

    DEFF Research Database (Denmark)

    Rikkert, Marcel G M Olde; Tona, Klodiana Daphne; Janssen, Lieneke

    2011-01-01

    New staging systems of dementia require adaptation of disease management programs and adequate staging instruments. Therefore, we systematically reviewed the literature on validity and reliability of clinically applicable, multidomain, and dementia staging instruments. A total of 23 articles...... describing 12 staging instruments were identified (N = 6109 participants, age 65-87). Reliability was studied in most (91%) of the articles and was judged moderate to good. Approximately 78% of the articles evaluated concurrent validity, which was good to very good, while discriminant validity was assessed...... in only 25%. The scales can be applied in ±15 minutes. Clinical Dementia Rating (CDR), Global Deterioration scale (GDS), and Functional Assessment Staging (FAST) have been monitored on reliability and validity, and the CDR currently is the best-evidenced scale, also studied in international perspective...

  15. The efficacy of using CAD for detection of breast cancer in mammography screening A systematic review

    DEFF Research Database (Denmark)

    Henriksen, Emilie; Lauridsen, Carsten Ammitzbøl

    Abstract Purpose: The aim of this systematic review is to present an overview of the available studies concerning the use of computer-aided detection (CAD) systems in screening mammography for early detection of breast cancer and compare the diagnostic accuracy and recall rates of single reading....... The literature search resulted in 1522 records after duplicates were removed. 1491 records were excluded by abstract and 18 were excluded after assessing the eligibility by full text reading. A total of 13 articles were included in this study. Results: The results for the single reading vs. single reading...... with CAD group indicate that the addition of CAD increases sensitivity and cancer detection rate (CDR). For the double reading vs. single reading with CAD group none of the studies reported significant differences in sensitivity and CDR. Adding CAD to single reading increased the recall rates and decreased...

  16. Sequence similarities of protein kinase substrates and inhibitors with immunoglobulins and model immunoglobulin homologue: cell adhesion molecule from the living fossil sponge Geodia cydonium. Mapping of coherent database similarities and implications for evolution of CDR1 and hypermutation

    Czech Academy of Sciences Publication Activity Database

    Kubrycht, J.; Borecký, Jiří; Souček, P.; Ježek, Petr

    2004-01-01

    Roč. 49, č. 3 (2004), s. 219-246 ISSN 0015-5632 R&D Projects: GA MZd NJ6747 Institutional research plan: CEZ:AV0Z5011922 Keywords : CDR1 * immunoglobulin Subject RIV: EE - Microbiology, Virology Impact factor: 1.034, year: 2004

  17. Characterization of the CDR3 structure of the Vβ21 T cell clone in patients with P210(BCR-ABL)-positive chronic myeloid leukemia and B-cell acute lymphoblastic leukemia.

    Science.gov (United States)

    Zha, Xianfeng; Chen, Shaohua; Yang, Lijian; Li, Bo; Chen, Yu; Yan, Xiaojuan; Li, Yangqiu

    2011-10-01

    The clonally expanded T cells identified in most cancer patients that respond to tumor-associated antigen such as P210(BCR-ABL) protein have definite, specific antitumor cytotoxicity. T cell receptor (TCR) Vβ CDR3 repertoire diversity was analyzed in patients with chronic myeloid leukemia (CML) and BCR-ABL(+) B-cell acute lymphoblastic leukemia (B-ALL) by GeneScan. A high frequency of oligoclonal expansion of the TCR Vβ21 subfamily was observed in the peripheral blood of CML and B-ALL patients. These clonally expanded Vβ21 T cells were correlated with the pathophysiologic process of CML. A conserved amino acid motif (SLxxV) was observed within the CDR3 region in only 3 patients with CML. Preferential usage of the Jβ segments was also observed in a minority of patients. The 3-dimensional structures of the CDR3 region containing the same motif or using the same Jβ segment displayed low similarity; on the contrary, the conformation of the CDR3 region containing no conserved motif in some T cell clones was highly similar. In conclusion, our findings indicate a high frequency of TCR Vβ21 subfamily expansion in p210(BCR-ABL)-positive CML and B-ALL patients. The characterization of the CDR3 structure was complex. Regrettably, at this time it was not possible to confirm that the Vβ21 T cell clones were derived from the stimulation of p210(BCR-ABL) protein. Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

  18. Review

    DEFF Research Database (Denmark)

    Van Den Hazel, H B; Kielland-Brandt, Morten; Winther, Jakob R.

    1996-01-01

    The yeast vacuole, which is equivalent to the lysosome of higher eukaryotes, is one of the best characterized degradative organelles. This review describes the biosynthesis and function of yeast vacuolar proteases. Most of these enzymes are delivered to the vacuole via the early compartments...

  19. Reviews

    NARCIS (Netherlands)

    Adema, Frits

    1995-01-01

    This is the second volume of a revision of Tabernaemontana (Apocynaceae). The volume covers the New World species (44) and the genus Stemmadenia (10 species). This part of the revision of Tabernaemontana comes up to the high standards set in the first volume [see the review by Leenhouts, Blumea 38

  20. Reviews.

    Science.gov (United States)

    Science Teacher, 1989

    1989-01-01

    Reviews a software planetarium package called "Sky Travel." Includes two audiovisuals: "Conquest of Space" and "Windows on Science: Earth Science"; and four books: "Small Energy Sources: Choices that Work,""Stonehenge Complete,""Uneasy Careers and Intimate Lives: Women in Science…

  1. REVIEW

    African Journals Online (AJOL)

    2012-03-01

    Mar 1, 2012 ... narrowing the gap between recommended treatment protocols in ... for pregnant women is complicated by the need to take into account the health and safety of both the ... meta-analysis as at July 2011 (which reviews the APR and other ... 0.82 - 3.18) and relative risk of birth defects in EFV-containing ART.

  2. Review

    Indian Academy of Sciences (India)

    Review. J. Astrophys. Astr., Vol. 36, No. 4, December 2015, pp. 623–634 ..... 4000 K ≤ T ≤ 10000 K. The processes (1b) are characterized in this paper via ..... Mihajlov, A. A., Sreckovic, V. A., Ignjatovic, L. M., Klyucharev, A. N. 2012, J. Cluster.

  3. Review

    NARCIS (Netherlands)

    Kalkman, C.; Adema, F.

    1998-01-01

    This book intends (according to the preface) to afford at once a review, a general outline of what has been accomplished, and a set of signposts for the future. It attempts to do so in three sections on Origin and Diversification of Primitive Land Plants (4 papers), Origin and Diversification of

  4. Review

    NARCIS (Netherlands)

    Wilde, de W.J.J.O.

    1994-01-01

    This review marks the appearance of Volume II, after the publication of Volume I, Pteridophytes and Gymnosperms, in 1990; several more volumes are expected in the future before completion of the Vascular plants as a whole. The present volume contains 73 families out of some 250-500 families which

  5. Preliminary report: NIF laser bundle review

    International Nuclear Information System (INIS)

    Tietbohl, G.L.; Larson, D.W.; Erlandson, A.C.

    1995-01-01

    As requested in the guidance memo 1 , this committe determined whether there are compelling reasons to recommend a change from the NIF CDR baseline laser. The baseline bundle design based on a tradeoff between cost and technical risk, which is replicated four times to create the required 192 beams. The baseline amplifier design uses bottom loading 1x4 slab and flashlamp cassettes for amplifier maintenance and large vacuum enclosures (2.5m high x 7m wide in cross-section for each of the two spatial filters in each of the four bundles. The laser beams are arranged in two laser bays configured in a u-shape around the target area. The entire bundle review effort was performed in a very short time (six weeks) and with limited resources (15 personnel part-time). This should be compared to the effort that produced the CDR design (12 months, 50 to 100 personnel). This committee considered three alternate bundle configurations (2x2, 4x2, and 4x4 bundles), and evaluated each bundle against the baseline design using the seven requested issues in the guidance memo: Cost; schedule; performance risk; maintainability/operability; hardware failure cost exposure; activation; and design flexibility. The issues were reviewed to identify differences between each alternate bundle configuration and the baseline

  6. Reviews

    Directory of Open Access Journals (Sweden)

    Philip Barker

    1998-12-01

    Full Text Available There were two copy-editing blunders in Clive Betts's review, in ALT-J 5 (3, of Shirley Fletcher's Designing Competence-Based Training, one in paragraph 2 line 1, the other in paragraph 3 line 8. The errors (the result of the Editor, Gabriel Jacobs, trying to perform a final proof of the journal at lightning speed in order to meet the printing deadline, and not of any mistake on the part of either Philip Barker or the University of Wales Press hardly affected meaning, but the fact that they appeared in a review of a book on competence makes the embarrassment all the more telling. The Editor apologizes, and thanks eagle-eyed readers. He has decided to read the book in the hope that such errors will not recur.

  7. Reviews

    Directory of Open Access Journals (Sweden)

    Wilma D'Ambrosio

    2013-12-01

    Full Text Available In the wake of the great interest raised by Maurizio Gabrieli’s review of the book Musical Networks. Parallel Distributed Perception and Performance (various authors; edited by Niall Griffith and Peter M. Todd, MA: MIT Press, Cambridge, 1999 which appeared in our last issue of Analitica, the present review section no longer follows the format used up to now but offers a survey of texts dedicated to the relationship between music analysis and technology. This decision was also made as a result of the request for more information on the subject by many of our readers. In coming issues we plan to extend this bibliography and comment on at least some of the most interesting texts published in recent years, among which we would immediately like to draw attention to the important work by Baroni, Dalmonte and Jacoboni published in 1999 (Le regole della musica. Indagine sui meccanismi della comunicazione, Torino, I Manuali EDT/SIdM, 1999.

  8. Fadiya & Ojoawo (21).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    (Received: 16 April, 2015; Accepted: 16 June, 2015). Biostratigraphic and ... and buildings) in recent years in various parts of ... the basin after the separation of South American ...... (25.50 – 17.25 m), a maximum flooding surface ... U.S.A. 4 ed.

  9. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    extremities in domestic poultry was a serious problem in the ... brought in to the Poultry Clinic of the Veterinary. Teaching Hospital ... disease. The affected quails that were unable to move eventually died, probably due to inability to access feed and water as described by. McNamee and Smyth (2000). Fig 1:Photograph of a ...

  10. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    the nurses and years of working experience had an impact on their .... home and returned the following night. ... in reading research findings include lack of ... well as involving nursing staff in ... lack of equipment, modern technology and time to.

  11. Valid Journal.cdr

    African Journals Online (AJOL)

    not caused by the tiny population of speakers alone as big languages have ceased to ... that an average native speaker of Yoruba would never concede to the fact that Yoruba ..... What will I eat to forget my benefactors? A sheep doesn't forget ...

  12. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    She had no history of dysmenorrhoea or dyspareunia. her last normal menstrual period was on 21 March. 2007, and she bled for 5 days. She developed cyclical pre-menstrual lower abdominal pain 12 years after menarche. She noticed brownish discharge from the umbilicus which occurred about 12 days of commencing ...

  13. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    were purchased from Bodija market, Ibadan,. Nigeria. TPP was ... field test. After weighing the rats, the tests were th performed on the 26 day of the experiment so as to investigate the ..... declines rapidly in the postnatal mouse neocortex.

  14. Valid Journal.cdr

    African Journals Online (AJOL)

    on to declare that mental science is revealing more clearly the nature of those ... with the socio-cultural changes of the society, and this evolution has come to be known as dance ... dispositions include exorcising illness and other form of misfortune ..... in Africa should do what their Asian counterpart did with their marshal art.

  15. march issue.cdr

    African Journals Online (AJOL)

    User

    vessel diseases are the often reported common aetiology in ... heart surgery could not be carryout and the histologic diagnosis ... and the systemic blood pressure reading was120/80. mmHg. ... putaminal infarct with surrounding oedema and.

  16. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    90mmHg6. All the information which included ethnicity, age, marital status, occupation, highest level of education attained, number of drugs taken, number of drugs prescribed, reason for dosage omissions or discontinuation of drugs were obtained ...

  17. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    treating discoloured non-vital teeth as a majority of the population may be unable to afford the alternative treatments like ceramic veneers and crowns. The aim of this study was to compare the efficacy and safety of 35% carbamide peroxide and sodium perborate as intracoronal bleaching agents; with a view to encouraging ...

  18. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    A cross-sectional survey of 1776 adults in Yola, North-East Nigeria was carried out in June 2007. A modified .... of tobacco leaf by native Indians in America while in. Asia; smokeless tobacco is an integral culture of the. South East Asians.

  19. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    INTRODUCTION. Informed consent is an established ethical and legal requirement for most diagnostic and therapeutic ... In some instances, information disclosure to a patient may ... benefits, risks and possible alternatives as well as possible ...

  20. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    (n=132, 31.5%) were in their third decade of life and the mean age was 33 ±. 4.2 years. ... difference with respect to age (p=0.374). Majority (n=249, 59.5%) were in the lower socio-economic class. ... need to strengthen the continuing oral health education programme, and ..... oral health beliefs and attitudes of Chinese in.

  1. map jalahalli.cdr

    Indian Academy of Sciences (India)

    RAJAJINAGAR. TUMKUR ROAD. GORAGUNTE PALYA. PLATINUM CITY. YESVANTPUR. M. E. S. R. O. A. D. ACADEMY. FELLOWS. RESIDENCY. ISRO. APTS. I T Qtrs. CFWRI. Play. Ground. R. IN. G. R. O. A. D. HMT SCHOOL. TUMKUR ROAD. CWB .7 km. 0. YESVANTPUR RAIL WAY STATION.

  2. JMBR vol 7.cdr

    African Journals Online (AJOL)

    Tope

    1. Department of Physiology, College of Medical Sciences,. University of Benin, P.M.B. 1156, Benin ... were on insulin, metformin or glibenclamide treatment and 25 non-diabetic subjects matched by ..... in type 1 Insulin dependent diabetes.

  3. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    aspirin use, effects of other drugs, liver diseases, uremia, etc. .... processed, and stored in the Weibel-Palade bodies of the ... aggregation tests occur. In patients with .... accumulation of urinary toxins. In most of .... resolves the problem quickly.

  4. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    Department of Medical Laboratory Science, School of Basic Medical. Sciences .... an impaired immune system leading to ... function in HIV infected people may be due ... disorders in chronic kidney disease. ... Immunology 2003;110:131-. 140.

  5. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    Aim: To determine the factors affecting the choice of surgery as a future career specialty among medical interns in a regional hospital in ... personal interest and career ambitions . In our setting however, the views of fresh medical ... using Graph pad instat software (2012). P value less than 0.05 was considered significant.

  6. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    environmental sanitation, poor health hygiene, overpopulation and poverty constitute major risk factors to ill-health. Whereas, all these risk factors have been ... lymphadenitis in their study. Yet again, studies by Gupta in India also show that granulomatous lymphadenopathy was the. 2 most common lesions encountered.

  7. Valid Journal.cdr

    African Journals Online (AJOL)

    metaphorically used to capture the essence of “racial turn” which in itself encapsulates .... list and our insistence that the rest should go fell on deaf ears because the Audition was ..... London: James Currency, 1994. Udumukwu, Onyaemachi.

  8. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    ... total antioxidant capacity (TAC) and its relationship with other risk factors like blood pressure and ... High sensitivity CRP, Total antioxidant capacity, chronic. 1. 2. 1. *Oboh ..... Erel O. A novel automated direct measurement method for total ...

  9. Valid Journal.cdr

    African Journals Online (AJOL)

    THE LEADERSHIP QUESTION IN CONTEMPORARY. NIGERIA: A STUDY OF .... honours degree in mathematics, and of course, the young. Onyema. The playwright .... the foreign business puppet, the men in high and low places who seek ...

  10. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    grade fever and anorexia . He had about five episodes a day, each lasting for a few minutes and relieved by applying pressure on the abdomen. There was no history of passage of bulky malodorous stool and no family history of diabetes mellitus. Physical examination revealed a chronically ill looking but alert boy.

  11. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    Smoking has also been associated with more aggressive disease but not with other clinical or biological characterics, particularly CD behaviour. Besides ... essentially normal. Abdomen was soft with mild tenderness in both iliac fossae; bowel sounds were heard and normal. No organomegaly. Rectal examination was also ...

  12. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    and compared with values at initiation of study. There was significant reduction in blood pressure (BP) from .... was done for serial values of the respective parameters monitored over the years. P value < 0.05 was ..... Praga M, Morales E. Renal damage associated with proteinuria. Kidney Int. 2002;62: supl. 82:42-46. 32.

  13. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    (PSA) and its role in cancer screening. Method of Scoring: Respondents who have heard of prostate cancer ... (52.2%) knew it plays a role in male reproduction while 150 (37.3%) were aware that the prostate gland ... remarkable improvement in the level of awareness and knowledge of prostate cancer after a 1 hour health ...

  14. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    body mass index, weight, height, waist circumference, blood pressure and fasting ... high prevalence of total cholesterol dyslipidaemia and low-density ..... Nigerian oil workers with type 2 diabetes ... and in white patients treated for essential.

  15. New draft.cdr

    African Journals Online (AJOL)

    HP USER

    1. & AU Ambursa. 1 . 1Faculty of Veterinary Medicine, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria ... and Preventive Medicine laboratory, Faculty of. Veterinary ... with ruminant offal, including are important risk factors. This may ...

  16. Enarvube & Atedhor (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    settlement increased by 1.4% and 1.5% respectively while forest and water decreased by 0.7% and .... forest, while water is composed of streams, rivers .... have shown that urban development is a threat to ... Sokoto-Rima Basin of N.W. Nigeria based .... the Atlantic rainforest region: Consequences for the hydrology of small.

  17. Journal 02.cdr

    African Journals Online (AJOL)

    Stephen

    dynamics. Several factors such as poor education, low personal income, availability of ... strategies are put in place. Studies on ... effects of gluts on the farm, farmer and the industry. .... Heading towards effective egg marketing in West Africa.

  18. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Nigeria, Department of Veterinary Surgery, University of Abuja, Abuja,. Nigeria. ... avoidance of ventral abdominal contact and refusal to stand on hind limbs ... The need to identify and manage pain in animals has been clearly ... abdominal surgery in animals. ... On the third postoperative day, the frequency of defeacation.

  19. Valid Journal.cdr

    African Journals Online (AJOL)

    Articulation Of Women And Gender Issues In Drama And Theatre ... Dr. (Mrs) Regina Ode & Paul ... the right to initiate divorce proceedings, it has also granted women the right to make ..... altar of greed and or poverty of parents. The girl.

  20. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    contribution of SCA related morbidities to paediatric admissions. This descriptive ... morbidities in children with. SCA were infections (44.1%), vaso-occlusive crisis (29.4%), severe anaemia .... system complications, particularly cerebrovascular ...

  1. march issue.cdr

    African Journals Online (AJOL)

    User

    frequent source of decision-making about health matters and personal care of its members . Family dynamics expect the physician-member of the family to be fully ... treat without distracting emotions .The family set up in developed countries are different from ours. In. Nigeria, extended family members are integrated into the ...

  2. HEALTH STATUS.CDR

    African Journals Online (AJOL)

    option. While child day-care setting is supported to provide opportunities for ... under two-year old children cared for in the home environment in a settlement in the junior staff ..... child's needs because of the far-reaching effects on the physical,.

  3. Journal 02.cdr

    African Journals Online (AJOL)

    Stephen

    In recent years, there has been a great increase in smallholder tomato cultivation in Nigeria and other African countries both as food and as cash crops. In some countries after a few good years,. The incidence and severity of common fungal and viral diseases affecting dry season tomato crop were determined on the tomato ...

  4. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    history of throat pain, hoarseness of the voice and cough, unconscious or sedated patients, patients too ..... acupuncture point. Anaesthesia 2004; 59: 647-. 651. 10. Post-thyroidectomy sorethroat following endotracheal intubation. ANZ J. Surg. 2001;. 71:669-671. 11. Tracheal intubation and sorethroat: a mechanical ...

  5. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    were processed for light and electron. m i c r o s c o p y . ... information exist particularly on the ultrastructural peculiarities .... deeper in the longitudinal ridges than those seen in the ... longitudinal ridges and shallow grooves of the membrane.

  6. Akinsanya (9).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    information on the parasitofauna of other relatives of S filamentosus. ... A large portion of the lagoon is shallow and less than 3.0 m deep. The Lekki lagoon is part ... They were subsequently processed for parasitic examination. Morphological ...

  7. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    of an integrated, cross-sectoral and transboundary approach to zoonotic ..... laboratory capacity for diagnosis. In Africa, ... between countries indicate a likelihood of dual or multiple .... H1N1 virus circulation: a modeling study. Lancet infectious ...

  8. Akinnifesi (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    processing temperatures and readily available doping materials. ... not a shallow donor but deep level below the conduction band ... simulations generate information at the microscopic level .... helps to examine the behaviour of defects when.

  9. Valid Journal.cdr

    African Journals Online (AJOL)

    into space in the form of waves similar to those of light and heat. The emergent of ... vehicles conveying atrocities through which the lives of the masses are threatened. .... structures, Eagle on radio pose no treat to an ordinary radio audience ...

  10. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    Nigerian Journal of Clinical Practice. Sept. ... were 4324 (58.4%) males and 3075 (41.6%) females, with a male to female ratio of 1.4:1. Disorders of the .... The most productive workforce group, aged 20 to ... well as empowering of the population, especially the women folk ... corroborated by the studies in Nnewi , with the top.

  11. Imande (7).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    In many of the variables used in the physical, biological, social and medical science, measurement errors are found. These errors, which could be problematic in .... (v) Use the values σ and σ to adjust for hm. hX measurement error in the variable (s) of interest and hence re-estimate the k-level model accordingly via Gibbs ...

  12. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    blood pressure discrepancy of greater than 30 mmHg between arms . ... inflammation. Presentations include hypertension, pain over ... unequal arm blood pressure, subclavian bruit and ... and a blood pressure difference of 30mmHg between.

  13. 05 Pavel 03.cdr

    African Journals Online (AJOL)

    User

    showing the ways in which the contents related to the state of subjugation, such as political repressions, forced migration, critique of the rulers, unfortunate national uprisings were all included in the books whose main plot took place in South Africa. Paradoxically, the symbolism of subjugation was accompanied by Polish ...

  14. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    relationship between body mass index and relative plasma viscosity in normal young Nigerian adults. A total of 22 normal undergraduate students (8 male and 14 females) of both sexes and between the ages of 18 and 27 years participated in the study. The age, weight and height of each subject was obtained and BMI was.

  15. Odukoya Abiodun (12).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    CONTAMINATION ASSESSMENT OF TOXIC ELEMENTS IN THE SOIL WITHIN. AND AROUND TWO .... The background value is average crustal values. (Taylor, 1964) in .... This is also confirmed by R- mode factor analysis ..... Application of.

  16. Omafuvbe (18).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    of utilizing BSG (a low cost readily available by-product of brewing) to ensure a sustainable reuse of its bio- resources. ... combustion or anaerobic digestion to biogas, adsorbent .... such as Zinc, Ferrous, Magnesium and Hydrogen ions in the ...

  17. Ukpebor (15).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Liquid chromatography-mass spectrometric conditions were ... environmental quality standards for water (EC,. 2000; EC, 2001). .... Synergi Fusion RP HPLC Column; 150 x 2.0 mm, .... applying a voltage to induce fragmentation into daughter ...

  18. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    To evaluate the level of awareness and acceptability of premarital screening for sickle cell disease amongst .... Table 2 shows the knowledge of sickle cell disease and premarital .... Nigeria, a predominantly islamic region, where religion was a ...

  19. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    7 and various authors have proffered diverse ... includes bio data (age, gender, date of admission); poison ... and water. Hospital Management ... City and demonstrated that the top most ... related to the absence of care givers because of ...

  20. MATERNAL BELIEFS.CDR

    African Journals Online (AJOL)

    1Department of Preventive Dentistry, Lagos University Teaching Hospital, ... parents interviewed believed that teething causes no .... prevalent in Nigeria but also in other parts of the world. 14 .... Ahmed I S, Elton A R, Karrar Z A. Knowledge,.

  1. Valid Journal.cdr

    African Journals Online (AJOL)

    common in Nigeria as captured in the world of the play The Woman in Black. Beyond highlighting ... through social structures such as the family (marriage, tradition, rites and other .... the determination of sex of a child is dependent on the mother. ..... International Conference on Performance held at University of th st. Ibadan ...

  2. Valid Journal.cdr

    African Journals Online (AJOL)

    A call for the rebirth of African culture and religion is borne out of the need. 14. 13 ... as thesis to elicit cultural ingredients that advocate for peaceful co-existence of ..... agent here acts on the psychology of the character. The Igbo cosmology of ...

  3. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Breast Cancer, war, Female, Undergraduate, Students,. 1. Sambo M.N, Idris S.H, Dahiru I.L , Gobir A.A. Department of Community Medicine, Ahmadu Bello University, Zaria .... Nigeria, South Asia and Brazil. . Knowledge and Practice of Self-breast Examination Among Female Undergraduate Students in a Northern Nigeria ...

  4. Valid Journal.cdr

    African Journals Online (AJOL)

    relation to women's representation in the Nigerian video film .... (India). And that, so many people who do not know how these recurring ... state. She is ritually sacrificed by her husband whose love for money would not let him value the woman who has gone .... “inhuman” show that the battle against gender inequality.

  5. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    ABSTRACT. There is paucity of information on the incidence and haematological changes associated with trypanosome infection in Nigerian fishes. This investigation examined randomly buffy coat and blood smears of Tilapia in the wild by direct microscopy for Trypanosomes and complete haematology were analyzed.

  6. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    local anaesthesia in Edinburgh and demonstrated ..... pre-assessment clinic is an effective aid to proper ... Pain controlled by oral analgesics ... applies to patients that meet the fast tracking criteria ... System related reasons for admission.

  7. Bamgbose (2).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    A decrease in equilibrium swelling ratio of the gel in SDS/TX-100 mixtures was observed with an increase in the ... one of them. Chitosan is biodegradable and .... distilled water, the films were air dried for 24 hrs. ... water gently with filter paper.

  8. December 2010.cdr

    African Journals Online (AJOL)

    Prof

    malnutrition and secondary bacterial infections. World Health ... A total number of 43 children with measles presenting at the National Hospital Abuja, seen over a 40 ..... immune response of Nigerian children Arch Dis. Child 1973; 48: 753-6. World Health Organization. Strategies for reducing global measles mortality Wkly.

  9. Fabiyi (19).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    ecosystems and three shoreline/marine ecosystem; Mangrove, Nypa and ... the inland ecosystem in the western part of the coastal areas around Ogun, Ondo ... Keywords: Ecosystem, Agricultural Produce, Fresh Water Agriculture, Marine ... local and global environmental conditions ( Sahid ...... A National Assessment of the.

  10. sept edition 2008.cdr

    African Journals Online (AJOL)

    User

    known. Among the pathogenetic mechanisms of the neurological defects of CML suggested in literature so far, hyperleucocytosis-induced stasis. (hyperviscosity syndrome) appears to be the most predominant .This is said to slow down the circulation through small blood vessels in the brainstem and results in deafness .

  11. nvj 36 3.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    multiple regressions and histogram distributions. TABLE I: .... made the group most widely varied. Adults' mandibles. Average .... within the bone (Chapnick, 1980; Freitas et al.,. 1994; Mc ... Merkel's cartilage and connections of ... The human.

  12. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    The purpose of this study was to develop an alternative technique for the determination of body .... Exclusion criteria included having stiffness or contracture on any of the .... For this reason, there are no direct studies to use to buttress or refute ...

  13. 6 Assessment.cdr

    African Journals Online (AJOL)

    user

    West African Journal of Applied Ecology, vol. 24(2), 2016: 67–89 ... approach to identify the key process controlling the .... chemical parameters analyzed in this study are presented in ...... Biological Engineers 52(2): 493–496. Leube A., Hirdes ...

  14. JMBR APRIL.cdr

    African Journals Online (AJOL)

    FinePrint

    Test group with reduced gingival bleeding did not have low birth weight deliveries. The 18 low .... February 2011. This was a longitudinal ... undetected multiple pregnancy deliveries ..... Source of fund: No external funding was provided for this ...

  15. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Clostridium sp (2.42%), Serratia sp (2.42%). Bacterial isolates from the waste workers were essentially similar to those isolated from the dumpsites although the latter were more heavily colonized. The highest bacterial burden was recorded from the top soil samples at Benin Bye-pass dumpsite with a mean viable count of.

  16. Oyesiku (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Department of Plant Science and Applied Zoology, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria. ... dehydration from which they rapidly recover on rehydration. The main ... under tap water on a metal screen (mesh 20) to.

  17. JMBR - SEPTEMBER 2013.cdr

    African Journals Online (AJOL)

    FinePrint

    Having noticed some phenotypic similarities in bacteria isolates from hands or clothings of waste dump workers .... of soil, leacheates, hand and clothing swabs were inoculated onto ... the second eye was left uninoculated to serve as control.

  18. Failure to Obtain Computed Tomography Imaging in Head Trauma: A Review of Relevant Case Law.

    Science.gov (United States)

    Lindor, Rachel A; Boie, Eric T; Campbell, Ronna L; Hess, Erik P; Sadosty, Annie T

    2015-12-01

    The objectives were to describe lawsuits against providers for failing to order head computed tomography (CT) in cases of head trauma and to determine the potential effects of available clinical decision rules (CDRs) on each lawsuit. The authors collected jury verdicts, settlements, and court opinions regarding alleged malpractice for failure to order head CT in the setting of head trauma from 1972 through February 2014 from an online legal research tool (WestlawNext). Data were abstracted onto a standardized data form. The performance of five CDRs was evaluated. Sixty relevant cases were identified (52 adult, eight children). Of 48 cases with known outcomes, providers were found negligent in 10 cases (six adult, four pediatric), settled in 11 cases (nine adult, two pediatric), and were found not liable in 27 cases. In all 10 cases in which providers were found negligent, every applicable CDR studied would have indicated the need for head CT. In all eight cases involving children, the applicable CDR would have suggested the need for head CT or observation. A review of legal cases reported in a major online legal research system revealed 60 lawsuits in which providers were sued for failing to order head CTs in cases of head trauma. In all cases in which providers were found negligent, CT imaging or observation would have been indicated by every applicable CDR. © 2015 by the Society for Academic Emergency Medicine.

  19. Evaluation of Susceptibility of Strains of Candida Albicans Isolated from AIDS Patients to Fluconazole and Determination of CDR2 Resistance Gene in Resistant Strains by RT-PCR Method

    Directory of Open Access Journals (Sweden)

    E Farahbakhsh

    2011-08-01

    Full Text Available Introduction & Objective: Nowadays, opportunistic fungi especially Candida albicans are the most common cause of life-threatening infections in immunodeficiency patients. Increasing Azole-resistant strains of C.albicans are a main problem in human immunodeficiency virus-infected patients. The aim of this study was to evaluate the CDR2 gene in C.albicans azole resistant strains, isolated from AIDS patients with oropharyngeal candidiasis by RT-PCR method. Materials & Methods: The present experimental study was conducted at Tarbiat Modares University of Medical Sciences in 2009. C. albicans isolates from HIV infected patients were identified by standard procedures, including germ tube formation, clamidospor and color of colonies on CHROM agar. At first, susceptibility of C. albicans isolates was assessed by disk diffusion agar technique. Then, CDR2 resistance gene was analyzed by RT-PCR and electrophoresis of the PCR products. Finally, patterns of the resulted bands were compared with standard fluconazole resistant strains. The collected data was analyzed using the SPSS software. Results: The results of drug sensitivity of 66 C. albicans isolates from AIDS patients revealed that 62.6% were susceptible, 8.6% were susceptible-dose dependent (SDD and 28.7% were resistant. In RT-PCR analysis, 6% of patients had the CDR2 gene. Conclusion: The use of phenotypic methods like disk diffusion agar, which is cheaper, along with genotypic methods, like RT-PCR, which provide the possibility of studying the mechanism of drug resistance, is recommended.

  20. The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening: a systematic review.

    Science.gov (United States)

    Henriksen, Emilie L; Carlsen, Jonathan F; Vejborg, Ilse Mm; Nielsen, Michael B; Lauridsen, Carsten A

    2018-01-01

    Background Early detection of breast cancer (BC) is crucial in lowering the mortality. Purpose To present an overview of studies concerning computer-aided detection (CAD) in screening mammography for early detection of BC and compare diagnostic accuracy and recall rates (RR) of single reading (SR) with SR + CAD and double reading (DR) with SR + CAD. Material and Methods PRISMA guidelines were used as a review protocol. Articles on clinical trials concerning CAD for detection of BC in a screening population were included. The literature search resulted in 1522 records. A total of 1491 records were excluded by abstract and 18 were excluded by full text reading. A total of 13 articles were included. Results All but two studies from the SR vs. SR + CAD group showed an increased sensitivity and/or cancer detection rate (CDR) when adding CAD. The DR vs. SR + CAD group showed no significant differences in sensitivity and CDR. Adding CAD to SR increased the RR and decreased the specificity in all but one study. For the DR vs. SR + CAD group only one study reported a significant difference in RR. Conclusion All but two studies showed an increase in RR, sensitivity and CDR when adding CAD to SR. Compared to DR no statistically significant differences in sensitivity or CDR were reported. Additional studies based on organized population-based screening programs, with longer follow-up time, high-volume readers, and digital mammography are needed to evaluate the efficacy of CAD.

  1. A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions

    Science.gov (United States)

    Shimizu, Kiminori; Paul, Sanjoy; Ohba, Ayumi; Gonoi, Tohru; Watanabe, Akira; Gomi, Katsuya

    2017-01-01

    Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To elucidate mechanisms underlying azole resistance, we identified a novel transcription factor that is required for normal azole resistance in Aspergillus fungi including A. fumigatus, Aspergillus oryzae, and Aspergillus nidulans. This fungal-specific Zn2-Cys6 type transcription factor AtrR was found to regulate expression of the genes related to ergosterol biosynthesis, including cyp51A that encodes a target protein of azoles. The atrR deletion mutant showed impaired growth under hypoxic conditions and attenuation of virulence in murine infection model for aspergillosis. These results were similar to the phenotypes for a mutant strain lacking SrbA that is also a direct regulator for the cyp51A gene. Notably, AtrR was responsible for the expression of cdr1B that encodes an ABC transporter related to azole resistance, whereas SrbA was not involved in the regulation. Chromatin immunoprecipitation assays indicated that AtrR directly bound both the cyp51A and cdr1B promoters. In the clinically isolated itraconazole resistant strain that harbors a mutant Cyp51A (G54E), deletion of the atrR gene resulted in a hypersensitivity to the azole drugs. Together, our results revealed that AtrR plays a pivotal role in a novel azole resistance mechanism by co-regulating the drug target (Cyp51A) and putative drug efflux pump (Cdr1B). PMID:28052140

  2. Antipurinergic therapy for autism-An in-depth review.

    Science.gov (United States)

    Naviaux, Robert K

    2017-12-16

    Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the abnormal persistence of a normal, alternative functional state of mitochondria? A small clinical trial published in 2017 suggests this is possible. Based on a new unifying theory of pathogenesis for autism called the cell danger response (CDR) hypothesis, this study of 10 boys, ages 5-14years, showed that all 5 boys who received antipurinergic therapy (APT) with a single intravenous dose of suramin experienced improvements in all the core symptoms of autism that lasted for 5-8weeks. Language, social interaction, restricted interests, and repetitive movements all improved. Two children who were non-verbal spoke their first sentences. None of these improvements were observed in the placebo group. Larger and longer studies are needed to confirm this promising discovery. This review introduces the concept of M2 (anti-inflammatory) and M1 (pro-inflammatory) mitochondria that are polarized along a functional continuum according to cell stress. The pathophysiology of the CDR, the complementary functions of M1 and M2 mitochondria, relevant gene-environment interactions, and the metabolic underpinnings of behavior are discussed as foundation stones for understanding the improvements in ASD behaviors produced by antipurinergic therapy in this small clinical trial. Copyright © 2017 The Author. Published by Elsevier B.V. All rights reserved.

  3. Department of Energy review of the National Spallation Neutron Source Project

    International Nuclear Information System (INIS)

    1997-06-01

    A Department of Energy (DOE) review of the Conceptual Design Report (CDR) for the National Spallation Neutron Source (NSNS) was conducted. The NSNS will be a new high-power spallation neutron source; initially, it will operate at 1 megawatt (MW), but is designed to be upgradeable to significantly higher power, at lower cost, when accelerator and target technologies are developed for higher power. The 53-member Review Committee examined the projected cost, schedule, technical scope, and management structure described in the CDR. For each of the major components of the NSNS, the Committee determined that the project team had produced credible designs that can be expected to work well. What remains to be done is to integrate the design of these components. With the exception of the liquid mercury target, the NSNS Project will rely heavily on proven technologies and, thus, will face a relatively low risk to successful project completion. The Total Project Cost (TPC) presented to the Committee in the CDR was $1.266 billion in as-spent dollars. In general, the Committee felt that the laboratory consortium had presented a credible estimate for each of the major components but that value engineering might produce some savings. The construction schedule presented to the Committee covered six years beginning in FY 1999. The Committee questioned whether all parts of the project could be completed according to this schedule. In particular, the linac and the conventional facilities appeared to have overly optimistic schedules. The NSNS project team was encouraged to reexamine these activities and to consider a more conservative seven-year schedule. Another concern of the Committee was the management structure. In summary, the Committee felt that this Conceptual Design Report was a very credible proposal, and that there is a high probability for successful completion of this major project within the proposed budget, although the six-year proposed schedule may be optimistic

  4. Clinical classification in low back pain: best-evidence diagnostic rules based on systematic reviews.

    Science.gov (United States)

    Petersen, Tom; Laslett, Mark; Juhl, Carsten

    2017-05-12

    Clinical examination findings are used in primary care to give an initial diagnosis to patients with low back pain and related leg symptoms. The purpose of this study was to develop best evidence Clinical Diagnostic Rules (CDR] for the identification of the most common patho-anatomical disorders in the lumbar spine; i.e. intervertebral discs, sacroiliac joints, facet joints, bone, muscles, nerve roots, muscles, peripheral nerve tissue, and central nervous system sensitization. A sensitive electronic search strategy using MEDLINE, EMBASE and CINAHL databases was combined with hand searching and citation tracking to identify eligible studies. Criteria for inclusion were: persons with low back pain with or without related leg symptoms, history or physical examination findings suitable for use in primary care, comparison with acceptable reference standards, and statistical reporting permitting calculation of diagnostic value. Quality assessments were made independently by two reviewers using the Quality Assessment of Diagnostic Accuracy Studies tool. Clinical examination findings that were investigated by at least two studies were included and results that met our predefined threshold of positive likelihood ratio ≥ 2 or negative likelihood ratio ≤ 0.5 were considered for the CDR. Sixty-four studies satisfied our eligible criteria. We were able to construct promising CDRs for symptomatic intervertebral disc, sacroiliac joint, spondylolisthesis, disc herniation with nerve root involvement, and spinal stenosis. Single clinical test appear not to be as useful as clusters of tests that are more closely in line with clinical decision making. This is the first comprehensive systematic review of diagnostic accuracy studies that evaluate clinical examination findings for their ability to identify the most common patho-anatomical disorders in the lumbar spine. In some diagnostic categories we have sufficient evidence to recommend a CDR. In others, we have only

  5. Department of Energy review of the National Spallation Neutron Source Project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    A Department of Energy (DOE) review of the Conceptual Design Report (CDR) for the National Spallation Neutron Source (NSNS) was conducted. The NSNS will be a new high-power spallation neutron source; initially, it will operate at 1 megawatt (MW), but is designed to be upgradeable to significantly higher power, at lower cost, when accelerator and target technologies are developed for higher power. The 53-member Review Committee examined the projected cost, schedule, technical scope, and management structure described in the CDR. For each of the major components of the NSNS, the Committee determined that the project team had produced credible designs that can be expected to work well. What remains to be done is to integrate the design of these components. With the exception of the liquid mercury target, the NSNS Project will rely heavily on proven technologies and, thus, will face a relatively low risk to successful project completion. The Total Project Cost (TPC) presented to the Committee in the CDR was $1.266 billion in as-spent dollars. In general, the Committee felt that the laboratory consortium had presented a credible estimate for each of the major components but that value engineering might produce some savings. The construction schedule presented to the Committee covered six years beginning in FY 1999. The Committee questioned whether all parts of the project could be completed according to this schedule. In particular, the linac and the conventional facilities appeared to have overly optimistic schedules. The NSNS project team was encouraged to reexamine these activities and to consider a more conservative seven-year schedule. Another concern of the Committee was the management structure. In summary, the Committee felt that this Conceptual Design Report was a very credible proposal, and that there is a high probability for successful completion of this major project within the proposed budget, although the six-year proposed schedule may be optimistic.

  6. Final environmental impact assessment of the Paducah Gaseous Diffusion Plant site, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    1982-08-01

    This document considers: the need for uranium enrichment facilities; site location; plant description; and describes the power generating facilities in light of its existing environment. The impacts from continuing operations are compared with alternatives of shutdown, relocation, and alternative power systems. (PSB)

  7. Environmental program audit, Paducah Gaseous Diffusion Plant, Paducah, Kentucky. Final report

    International Nuclear Information System (INIS)

    1985-08-01

    The environmental monitoring program, environmental control equipment and its use, and the facility's compliance with DOE orders, Federal and State laws and regulations were evaluated in this audit. No imminent threat to public health and safety was discovered. A needed quality assurance program is being added. Recommendations are given

  8. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    Challenges include poor living conditions, poor accessibility, lack of infrastructure and .... training local staff on specific assignments, as such trained staff have been ... out-sourced at inconvenience and increased costs for the patient. None of ...

  9. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    We present our experience with this treatment modality over a three ... been called to question in the light of development of less invasive ... Materials and Methods. This is a .... The patient was undergoing dialysis for symptomatic azotemia.

  10. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    Trauma continues to be a major cause of morbidity and mortality world over. ... rib fracture(s) (23.8%), hemopneumothorax (14.3%), hemothorax (7.1%), ... The mortality rate was 2.4%. Only 7(16.7%) patients were seen beyond the first outpatient clinic appointment. Conclusion. Most patients arriving at the hospital survived, ...

  11. NJS July 2011 for Ogidi.cdr final.cdr

    African Journals Online (AJOL)

    communication skills as a basis for developing an effective education program me. Materials and Method. Residents in the department of surgery were surveyed after a weekly mortality and morbidity meeting. The questionnaire contained 4 demographic items; age, gender, junior or senior registrar and postgraduate year of ...

  12. Ajikah et al (11).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Faculty of Science, Senate Building and New Hall respectively. A total of 3,495 palynomorphs belonging to about 22 families were recovered in all. The Poaceae family dominates representing 13.67 % of the total palynomorph count, followed by Cyperaceae (12.72 %) Euphorbiaceae (5.34 %) Mimosaceae (8.89 %), Fern.

  13. Oresajo et al (15).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    2 (2015). SEQUENCE STRATIGRAPHY AND STRUCTURAL ANALYSIS OF THE EMI FIELD,. OFFSHORE ... flooding surfaces, which subdivided the stratigraphic succession within the Emi Field into three depositional sequences. ..... American Association of Petroleum Geologists, ... Africa. U.S. Geological Survey Open-File.

  14. Chemical Data Reporting rule (CDR)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains information on chemicals that company's produce domestically or import into the United States during the principal reporting year. For the 2012...

  15. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    between 40 and 49 years old. Majority of the study women (98%) were married. Four (4%) of the respondents had learned about pap smear and none knew what Pap smear screened for. None of the respondents had ever had a pap smear taken before. Thirty (30%) of the respondents had heard of the cancer of the cervix.

  16. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    affirm that water is life, also water is necessary for domestic uses like .... these metals can be transported by particulate matters to the sediment which serve as the sink for .... Biomaker of Black Jaw Tilapia From Lagos Lagoon Agrosearch.

  17. Adejoro et al (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    band gaps of the complex with different substituents. These properties were obtained ... Keywords: Geometric Parameters, Dipole Moments, Band Gaps Modelling. ABSTRACT. 533 ..... Rhodium and Iron. Complexes and Transition States: A.

  18. Afolabi et al (17).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    and as glaciers and about 4% of the earth's water is present in the ... veins which were exposed in some places by erosion. Figure 1: .... Field VES Curves and Model Parameters of VES 2, VES 1 and VES 3 (from Southeast to. Northwest).

  19. Asaolu et al (16).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    antioxidants, change in gene expression and .... Wistar albino rats of either sex were divided into ... The liver sample (1g) from each rat was transferred .... Table 5: Percentage ABTS Radical Scavenging Activity of Extract and Fractions ofC.

  20. Olorunfemi et al (16).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Oily wastewater pollution not only affects ... control and prevent marine pollution in the ... the Atlantic Ocean in April 2014. ..... Journal of Research in Forestry, Wildlife and ... parameters of River Guma, Benue, ... Emerging risk from ballast water.

  1. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    2018-04-26

    Apr 26, 2018 ... Methods: Fifty PH sessions of 20 minutes each was applied on the subject. Results: On ... Abstrait. Objectifs: Un garçon de quatorze ans a reçu un diagnostic de déficience visuelle de l'œil droit depuis ... Pulmonary Disorder (COPD) (10), Musco- skeletal .... Effect of 'pranic'healing in chronic musculoskeletal.

  2. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    National Programme for Food Security, Nigerian Agricultural Insurance ... Notwithstanding, the impact of this bank is yet to be felt as expected by its target .... indicated that they usually give gifts to credit officers so as to fast-track the farm credit .... nothing bad about it and are more interested in accessing loan than to follow ...

  3. Ajayi and Ogunjobi (10).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    1Dept of Wildlife and Ecotourism Mgt, Federal College of Wildlife Mgt, New Bussa, Niger State ... of the composition of large animals visiting salt lick sites during the day-time at the Borgu ... For effective in-situ wildlife management capable.

  4. PDF-JOURNAL 2006.cdr

    African Journals Online (AJOL)

    also medical benefit and contribute significantly to ... sensation produced by light, invading the eyes as to. 1. 2. 3. 4. 4 ... such as aged related macular degeneration, ... pigment epithelial retinopathy and other retinal or macular problems could benefit from high dose of T. ... gender, refractive error, and occupation from Abia.

  5. Alao and Oludare (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Hydrocarbon accumulation resides within the ... the data in various regions of the reservoir and grouping them together ... pay facies allowing for prediction of oil saturation and reservoir ..... Divergent and Passive Margin Basin. American ...

  6. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    Leaf area models are simple, accurate and non-destructive. They are important in many ... area model for S. macrocarpon using linear measurements. A total of 80 fully opened ... Regression analysis of leaf area obtained from graph tracing as ...

  7. Oyebola et al (23).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    3+ described elsewhere (Oyebola et al., 2010). Ho absorption peaks were obtained from transmission studies carried out with a Cary 5000. UV-VIS-NIR spectrophotometer and corresponding absorption coefficients deduced using the Beer-Lambert law. Spectral emission measurements were carried out using the schematic ...

  8. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Abstract. Endless efforts are required in the investigation of the best organ preservative. Normal Saline, 5% dextrose, Darrows and. Ringers' Lactate were used as preservatives with the view to investigate the prospect of kidney survival in these solutions post harvest at the Veterinary Teaching Hospital, Ahmadu Bello ...

  9. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    2Department of Theriogenology and Animal Production ... male Jack-Russel was presented to the Usmanu Danfodiyo University Veterinary Teaching Hospital, Sokoto .... Animal. Hospital Association. ... Journal of the American Animal Hospital.

  10. Oresajo et al (15).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    3D seismic data, wireline logs from six wells, checkshot and biostratigraphic data were used to subdivide the stratigraphic section within the Emi Field, eastern Niger Delta, into packages of sediments bounded by chronostratigraphically significant surfaces. The results revealed two sequence boundaries and three maximum.

  11. Edegbai and Emofurieta (12).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    ABSTRACT. 131. INTRODUCTION. The Maastrichtian Mamu Formation has been described as a cyclotherm comprising Dark Shale, sandstones and sandy shales (with coal beds at various stratigraphic levels) deposited in a marginal marine environment (tidal flat - estuarine setting; Ladipo, 1988).This Formation exhibits.

  12. Ayeni and Egharevba (14).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    STUDIES OF SOME MORPHOLINO- AND METHYLPIPERAZIN-1-YL MANNICH. LIGANDS AND THEIR ... Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria. *Corresponding ..... Acetophenone. International Journal of.

  13. Okiyi et al (8).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    A geoelectric investigation, involving 1-D Vertical Electrical Sounding (VES) with the Schlumberger array and 2- ... curves were quantitatively interpreted and the results were used for the generation of ..... and Electromagnetic Investigation of.

  14. 4 Hydrogeochemical Framework.cdr

    African Journals Online (AJOL)

    user

    indicates the strength of the mutual relation amongst the hydrochemical ... the world are exposed to health risks due to ... the Bureau of Indian Standards, Drinking ... fluoride concentration in drinking water in ... availability of potable water to these .... regolith is thin or absent, ample ..... drinking water consumption within the.

  15. Adewuyi et al (19).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Ife Journal of Science vol. 17, no. ... Department of Chemistry, College of Physical Sciences, Federal University of Agriculture, Abeokuta, Ogun State,. Nigeria. ... coatings, paint and other industrial coatings as binder in ..... library generation.

  16. Jacob et al (21).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    city of Kaduna, Nigeria vis-à-vis the soil physicochemical properties.The city was ... Lead and cadmium, like arsenic and ... danger of soil contamination and to evaluate the impact of waste ..... remediation study of metal contaminated soils with ...

  17. Ajayi et al (24).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    In this study, an assessment of the analgesic potential of Zea mays L., Nauclea latifolia Sm leaf; leaf and stalk of. Manihot esculenta Crantz was made. Pain was induced by 0.6% acetic acid in high fat diet-manipulated, alloxan- induced hyperglycaemic rats. Paracetamol® (65 mg/kgBW) served as positive control, while olive ...

  18. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    The fertility trend observed is mainly explained by use of contraception. The contraceptive .... 2005/06 showed that, for the first time in Zimbabwe, the TFR declined to .... this well given a long list of challenges the country is facing? One would ...

  19. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    L) by Gas- ... and lipophilic properties that enable them penetrate rapidly into insects and also interfere with ... essential oils of basil did not lose their viability. ... an eco-friendly alternative to synthetic fumigants in the control of this insect pest.

  20. Fehintola et al (13).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    pollutant were adsorbed from lead, cadmium and .... It is well documented that the essential characteristic of the ..... existence of adsorbent- adsorbate interactions, the heat of ...... bone mineral density in healthy late post- menopausal Dutch ...

  1. Umebese and Fabiyi (4).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    . ... Treatment of stressed plants with SA under chelated Al toxicity (Al + SA + EDTA) improved .... used as a chelate for zinc (Salama etal., 2012). .... Generally, plants subjected to Al+EDTA .... effect of EDTA on the growth of Indian mustard.

  2. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    society the female partners are more willing to per take in ... focused on women without much consideration given to .... probably due to poor knowledge and subsequent .... Divorced. 126. 159. 15. 42.0. 53.0. 5.0. Level of Education No formal.

  3. Cover Final May.cdr

    Indian Academy of Sciences (India)

    user

    Kane was responsible for this development and RN had a keen interest in it. The three years ... the role of language in problem solving and how children learn language. Some of his insights ... linguistics and cognitive sciences. He was one of ...

  4. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    This study aimed at determining the prevalence, sociodemographic features, aetiology, clinical presentation management .... accident, assaults, falls and sports injuries (3,4,7). .... managed with trauma and neurosurgical team. Foreign bodies ...

  5. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    Moroccan population has known a growing demographic trend. ... postnatal care should be enhanced especially towards poor women living in rural areas and ... percentage of married women using contraception .... of births assisted by skilled personnel. 30. 70. 95. % of newly mothers who received antenatal care 40. 71.

  6. yahaya et al.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    bones in Skull of the Camel (Camelus dromendarius) in Nigeria. SUMMARY. The morphological features of facial region of the camel skull were investigated. A total of 42 camel skulls. (30 mature and 12 immature) from three geographical locations. (Maiduguri, Kano and Sokoto) in. Nigeria were used in this study. The.

  7. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    Analytical tools used for the study was Stochastic Frontier. Model (SFM). ..... The maximum likelihood estimates of the parameters of the frontier models for the cultured fish farms are ... The table shows the estimates of regression and variance.

  8. Olorunfemi et al (11).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Keywords: Bilge water, RAPD, DNA damage, Allium cepa, Ships. ABSTRACT. 121 ... component in the socio-economic development of any given maritime .... categories of industries. Lead, copper ... used produced bands between 120 and 1300 bp in length (Plates 1 -5). .... enzyme activities in Allium cepa L. Being a th.

  9. Elueze et al (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    OBAJANA MARBLE DEPOSIT IN THE PRECAMBRIAN BASEMENT COMPLEX OF. CENTRAL NIGERIA. 1 .... analyses and physical and mechanical properties determinations. .... bases, construction stone and ornamental stone. The loss on ...

  10. Umukoro et al (4).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    cost adsorbent for the removal of heavy metal ions from wastewaters. Keywords: Adsorption ... specific surface area, high adsorption capacity and special surface chemical .... increasing negative charge density on the adsorbent (Olayinka et ...

  11. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    La maladie rénale chronique constitue un problème de santé publique avec une incidence croissante, une prévalence, de mauvais résultats et un coût élevé. La sensibilisation et le dépistage de l'insuffisance rénale chronique demeurent faibles partout dans le monde. Ainsi, des millions de personnes à travers le monde ...

  12. Oke et al (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    River Basin using three empirical formulae which include modified Chaturvedi formula, Krishna Rao ... Keywords: Empirical Formulae; Groundwater Recharge; Ogun River Basin; Oshun River Basin, Inter Item ..... Modeling of Groundwater in.

  13. Okiongbo and Soronnadi (22).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    et al., 1999), evaluation of basin slope stability. (Dugan and ... pore medium. .... F, and takes the clay effects into consideration is c used in this ..... Ha – aquifer thickness from VES data, ρ – pore water resistivity, K – hydraulic conductivity, w.

  14. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    aspergilloma or complications such as bronchiectasis are also known causes of haemoptysis world wide. However, cystic fibrosis (CF) is the commonest etiologic factor in Europe. Haematemesis may be misinterpreted as haemoptysis, particularly when accurate history is not possible in children. Therefore, bleeding from.

  15. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    breast cancer is associated with high rate of mortality and morbidity. The aim of this study ... Results: During the period of study, 166 females with symptomatic breast lesions had diagnostic .... case use of ultrasonography as an adjunct would.

  16. Cover Final May.cdr

    Indian Academy of Sciences (India)

    user

    tions on the sym bols ofthe initialtext,a sim ple exam ple being to replace each letter ... French Mathematical ... In a visionary paper on the m ilitary cryptography pub- lished in ..... m any years, or decades later, in a com pletely unpre- dictable w ...

  17. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    Abstract. Objectives: The main aim of the study was to explore the influence of family ... assessment device while BMI and blood pressures measures were used to ... number of one-parent mothers had normal BMI (49%) compared to .... self, nuclear family emotional system, family ..... Parenting Style and Family Functioning.

  18. sept 2 edition 2009.cdr

    African Journals Online (AJOL)

    User

    media may go along way to increase contraceptive up take. .... women . The finding of Muslim acceptors being twice their Christian counterpart is a ... Its Social,. Political, Economic, Moral and Religious aspects. Islamic publication Ltd. Lahore.

  19. Dankwah et al (12).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    The optimization of process parameters to give low concentration of acrylamide ... products such as potato chips, deep-fat fried foods, crisp bread ... Factors. Level of Variation. Soaking. H3PO4 /Citric acid. Amount of additive. 0.1 – 1.0 g or mL.

  20. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    everyone will enjoy life at all levels of human endeavor. This statutory ..... sector because of poor electricity, the internet and weak communication .... International Student Edition. Mcgraw-Hill Kogakusha, Ltd, 1960. 5. The Nation, Thursday ...

  1. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    dissemination of antibiotic resistant organisms as well as serve as a reservoir ... The process of transporting these food products from the farm to households ... pattern of bacteria associated with raw vegetables and fruits in the study area, and ...

  2. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    Department of Basic Medical Sciences, Achievers University, Owo, Nigeria. 4. Department ... Research Journal of Health Sciences subscribed to terms and conditions of Open Access publication. Articles are ..... Bearing in mind that these two ...

  3. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    reproductive health services. ... Cet article se sert des données tirées des Enquêtes Démographiques Ghanéennes de 2003 et 2008 ... family planning services and negative attitudes of ..... The vigorous social marketing campaigns carried out.

  4. Adewale et al (18).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    MATERIAL IN SOIL AND MINE TAILINGS OF AWO AND EDE, OSUN-STATE,. NIGERIA. 1*. 1. 2 ... The materials may be original (such as uranium and thorium) or decay .... following equation (Beck et al., 1972). D = 0.042A (K) + 0.429A.

  5. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Abstract. This paper reports two scenarios whereby goring injury sustained by a Bunaji bull and a Yankasa lamb were managed by pastoralists before the cases were presented to the Large Animal Clinic Unit of the Veterinary Teaching Hospital, Ahmadu. Bello University, Zaria. Anamnesis of the cases presented was that ...

  6. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Abstract. Blood samples from external jugular vein of camels presented for slaughter at randomly selected slaughter houses in northwestern Nigeria were collected. This is to determine some haematological baseline data and to investigate the influence of pulmonary lesions on the blood parameters studied. Accordingly ...

  7. SJVS Draft Vol 9.cdr

    African Journals Online (AJOL)

    HP USER

    Abstract. Despite the efforts made by stake holders towards eradication of pathogens from poultry flocks, Newcastle disease virus infection is still of continuing economic concern in Nigeria. Consequently, adapting prompt, sensitive and inexpensive diagnostic techniques will without doubt clamp down on the menace of the ...

  8. Ajayi et al (24).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    EXTRACTS IN HIGH FAT DIET-MANIPULATED HYPERGLYCAEMIC RATS. Ajayi, E. I. O.* .... 700 nm (to correct for haze) against a blank cell filled with ... did not suffer any lethal effect or death except two .... of the frequency of phenylquinone-.

  9. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    risk of death and lifelong complications because they are still not well ... Ghanaian cultural and religious settings. This makes it ..... system factors such as attitude of health workers and the ... only contraceptives that provide dual protection form.

  10. Njan et al (9).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    observed for the reaction time to the thermal stimulus. The reaction time .... possess many toxic adverse effects. There is, therefore, a dire ..... Oxide and Nitric Oxide Donors. Pharmacological ... in the mouse without increasing blood pressure.

  11. Akanni et al (11).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Viscosity is a measure of the resistance of one part of a fluid to move ... exponential factor in the Arrhenius equation, E is η. RT. E. A. 303 .2 log log. 10. 10 h h. +. = .... the relationship,. (Feakins, 1974). ..... An empirical formula for the relation ...

  12. Shaibu and Watkins (3).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    compound 1 was oily with 68 % yield. Mass spectra data of compound GL1a, GL1b and GL1c confirmed the proposed structure of the Schiff bases. The spectra mass of three compounds show the molecular ion peak corresponding to theirformulation. The resulting Schiff bases were intensely coloured. The intensities of the ...

  13. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    This paper examines the impact of in ation on economic growth in Sub-Saharan Africa in ... because of the importance of in ation rate in ... ongoing slowdown in private sector credit ..... Optimal in ation for the U.S. economy. ... United States.

  14. 5 Water Quality.cdr

    African Journals Online (AJOL)

    Administrator

    The water quality assessment conducted in the Densu, Birim and Ayensu Basins of Ghana in the Okyeman area ... All the mean nutrient values for Densu, Birim and Ayensu were not significantly .... variability in the composition of the river.

  15. Ezeh et al (17).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Source apportionment results by PCA resolved five sources (Soil dust, 31 %; Sea ... Non-ferrous smelting, 12 %; Heavy oil combustion, 10 %; Biomass burning, 9 %; Sea spray, 6 % ) for PM ..... classified as a non-toxic metal; however exposure.

  16. Idowu et al (19).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    aquifer flow (MacDonald et al., 2005). Typically, it travels vertically downwards through the unsaturated zone to the water table, from where it flows according to the hydraulic gradient, until it reaches an area of discharge where it occurs as springs or seepages, providing part of the dry season flow and constituting part of the.

  17. Falebita et al (4).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    This study evaluated and assessed the organic richness and some ... organic carbon (TOC), thickness, volume of shale (VShale) and effective porosity (PHIE) from wireline logs. ..... A: Thickness vs TOC .... Origin (Source or non-Source) and its.

  18. Abdul et al (9).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    fishery in Nigeria, there is dearth of information on the species' biology in the ... Biometric data such as body weight (BW to the nearest 1 ... This was checked with integrated methods of Pauly (1980). ..... Fisheries Techniques. Bethesda, Amer.

  19. RJHS 5(4).cdr

    African Journals Online (AJOL)

    USER

    Background:Caecal intubation is an important measure of the quality of colonoscopy. Information on the effect of the time of colonoscopy on caecal intubation rate (CIR) is scarce. This study aimed to compare .... CIR had been studied, but information on the .... interval between the start of bowel preparation and the timing of ...

  20. Okonji et al (6).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    +234 806 016 4991, okonjire@yahoo.co.uk; reokonji@oauife.edu.ng. (Received: 26th ... apple, mango, peach, and bitter almonds (ATSDR,. 2006). In plants ... Inc., Benicia Ca., USA. Other chemicals used .... The elution profiles after reactive ...

  1. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Noah Olatoye

    contributions into the scheme, the investment ... Insurance Trust Fund in 1993). .... to the employees and also unload pension liabilities to third parties like insurance companies, and shifts to DC .... thereby increasing economic activities and.

  2. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    emissions and energy consumption to economic growth and strong unidirectional causality running from CO2 emissions, energy ..... Estimating the environmental Kuznets curve for Spain by considering ... In uences of indirect lifestyle aspects.

  3. African Journal June 2011.cdr

    African Journals Online (AJOL)

    SEGUN ADENIJI

    Pregnancy rates were higher in day 3 group (55/131, 42%) when compared to ... insemination or ICSI) of pronuclear morphology as a predictor of ... until the time of the transfer. Embryos were ..... A (2001) The effect of pronuclear morphology ...

  4. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    Mean. Std.Dev. Minimum. Maximum. Output in (kg). 2206.4. 933.47. 650. 5000. Pond size (cm2). 807.8 ... Table 3: Stochastic frontier estimates for catfish production in Ijumu LGA. Variables. Parameter ... Variance Parameter. Sigma square δ2.

  5. Adeoye et al (5).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    2 (2015). HAEMATOLOGY AND SERUM BIOCHEMISTRY OF F AND F PIGS PRODUCED BY. 1 ... Animal Production and Health, Federal University, Katsina State. ABSTRACT ... volume and haemoglobin of guinea fowl, with the male having ...

  6. Akinlabi et al (10).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    VES 12. VES 11. VES 10. VES 9. VES 8. VES 7. RIVER. CHANNEL. BH01. BH02. BH03. BH04. BH05. BH06. 1833. 2592. 4272. 4161. 3025. 2687. 708. 562. 265. 1272. 734. 2989. 9270. Geoelectrical interface. Lithologic interface. Distance along dam axis(m). Resistivity value in ohm-m. Borehole point. VES station. CH 100.

  7. 1 Ecosystem-based.cdr

    African Journals Online (AJOL)

    Administrator

    Abstract. The ecosystem approach is a widely accepted framework for natural resource ... Here, we present a set of indicators, and a toolkit to aid their application, that are intended to support the ... Ability to adapt to different spatial scales ... growth of plants and algae, which may increase to create .... taxonomic resources).

  8. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    improvements in manufacturing and trade activities, which ... Product (GDP) recorded a slight improvement within the period ... tenor of the forward sales cycle from 180 days to 30 days ... decrease in Foreign Direct Investment (FDI) and other ...

  9. Adekunle et al (8).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    BIODEGRADATION OF PETROLEUM OILS BY FUNGI ISOLATED FROM OIL ... compounds which possesses a measurable toxicity towards ... indigenous organisms, including oil-degrading ... papers were dipped in 250 ml crude oil contained.

  10. Laniyan et al (1).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Pollution of groundwater has become a major environmental problem. Anthropogenic ... drinking water comes from aquifers (Forster et al.,. 1998). Aquifers ... improvement in public health. ..... Arsenic (As): Chemical properties,. Health and ...

  11. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    with equally huge market given its population size-180 million. ... industrialization as speci ed in the Economic Recovery and Growth Plan (ERGP), the .... industry lacks a strong and positive brand image among consumers and investors, as.

  12. Agro. No. 2.cdr Corrected

    African Journals Online (AJOL)

    TOSHIBA

    In Nigeria, genotype by environment interaction effect on maize grain yield is ... This is because growing of high yielding and stable maize ... flexibility in planting dates which enables multiple plantings to spread the risk of crop failure due to ... includes analysis of variance followed by a joint regression (JR) analysis to ...

  13. Asowata et al (10).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Thirty six river sediment samples were collected from Ala River, Akure, and were ... activities such as vehicle related workshops, road junctions, municipal waste, abattoir and farm gardens were ... The toxicological risks of consumption of water.

  14. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    2018-04-24

    Apr 24, 2018 ... both days and the unit the patient was managed; the type of surgery done and the age ... entre les valeurs de l'hématocrite sur les deux jours et l'unité du patient a été géré; le type de chirurgie .... Human Coagulation Factors.

  15. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    2018-04-27

    Apr 27, 2018 ... Butanol extract of Manihot esculenta leaf modulated cigarette butt ... Manihot esculenta leaf, in vivo, and against the effects of cigarette butt leachate, in vitro on liver ..... Novotny T. E., Lum K. and Smith E. Cigarettes butts and ...

  16. Oke et al (3).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    β Postgraduate Student in Department of Civil Engineering, Obafemi Awolowo University, Ile-Ife, Nigeria ... The study revealed that flow in pipe network analysis varied with the method. The flow was a ...... Applied Hydraulic ... Chem Eng Sci.

  17. PDF-JOURNAL 2006.cdr

    African Journals Online (AJOL)

    eyes equally; functions mostly affected include ... and 30 after which it decreases as a function of age, colour vision and visual fields also diminish with age. ... up around 7-8 years of age. ... increased depth of focus induced by senile and.

  18. NESG EPR Journal.cdr

    African Journals Online (AJOL)

    Tosin Bashir

    Among many other nancing models, Public-Private. Partnerships ... Integrated Infrastructure Master Plan (NIIMP), enactment of PPP legislation and implementation support ... is expected to operate as a PPP to the tune of ... This company was.

  19. RJHS 6(1).cdr

    African Journals Online (AJOL)

    USER

    Challenges of teaching Basic Medical Sciences in Nigeria ... In Nigeria, didactic lectures which are the predominant supervised learning environment ... changed and student population increasing without comparative expansion of resources, ...

  20. Independent Peer Review of Communications, Navigation, and Networking re-Configurable Testbed (CoNNeCT) Project Antenna Pointing Subsystem (APS) Integrated Gimbal Assembly (IGA) Structural Analysis

    Science.gov (United States)

    Raju, Ivatury S.; Larsen, Curtis E.; Pellicciotti, Joseph W.

    2010-01-01

    Glenn Research Center Chief Engineer's Office requested an independent review of the structural analysis and modeling of the Communications, Navigation, and Networking re-Configurable Testbed (CoNNeCT) Project Antenna Pointing Subsystem (APS) Integrated Gimbal Assembly (IGA) to be conducted by the NASA Engineering and Safety Center (NESC). At this time, the IGA had completed its critical design review (CDR). The assessment was to be a peer review of the NEi-NASTRAN1 model of the APS Antenna, and not a peer review of the design and the analysis that had been completed by the GRC team for CDR. Thus, only a limited amount of information was provided on the structural analysis. However, the NESC team had difficulty separating analysis concerns from modeling issues. The team studied the NASTRAN model, but did not fully investigate how the model was used by the CoNNeCT Project and how the Project was interpreting the results. The team's findings, observations, and NESC recommendations are contained in this report.

  1. ERG [Engineering Review Group] and GRG [Geologic Review Group] review of the horizontal versus vertical modes of waste emplacement at the Deaf Smith County site, Texas

    International Nuclear Information System (INIS)

    Chytrowski, B.R.

    1988-01-01

    The Engineering Review Group (ERG) and Geologic Review Group (GRG) were established by the Office of Nuclear Waste Isolation (ONWI) to help evaluate specific issues in the US Department of Energy's nuclear waste repository program. The December 1985 meeting and the February 1986 meeting dealt with the evaluation of the Fluor Technology, Inc., architect-engineer recommendation of the horizontal mode of waste package emplacement for the Site Characterization Plan Conceptual Design Report (SCP-CDR). The ONWI recommendation regarding horizontal and vertical modes of waste package emplacement and associated studies was reviewed. This report documents the ERG and GRG's comments and recommendations on this subject and ONWI responses to the specific points raised by these groups. The ERG and GRG joint review groups concurred with ONWI recommendations that additional studies are required in order to reach a decision on the method of emplacement to be used. In the opinion of these groups, both methods can be implemented; however, should the decision be reached today the vertical mode would be preferred

  2. RDF gasification with water vapour: influence of process temperature on yield and products composition; Gassificazione con vapore del CDR: influenza della temperatura di processo su rese e composizione dei prodotti

    Energy Technology Data Exchange (ETDEWEB)

    Galvagno, S.; Casciaro, G.; Russo, A.; Casu, S.; Martino, M.; Portofino, S. [C. R. ENEA Trisaglia, Rotondella (Italy). PROT-STP

    2005-08-01

    The opportunity of using RDF (Refused Derived Fuel) to produce fuel gas seems to be promising and particular attention has been focused on alternative process technologies such as pyrolysis and gasification. Within this frame, present work relates to experimental tests and obtained results of a series of experimental surveys on RDF gasification with water vapour, carried out by means of a bench scale rotary kiln plant at different process temperature, using thermogravimetry (TG) and infrared spectrometry (FTIR), in order to characterize the incoming material, and online gas chromatography to qualify the gaseous stream. Experimental data show that gas yield rise with temperature and, with respect to the gas composition, hydrogen content grows up mainly at the expense of the other gaseous compound, pointing out the major extension of secondary cracking reactions into the gaseous fraction at higher temperature. Syngas obtained at process temperature of 950{sup o}C or higher seems to be suitable for fuel cells applications; at lower process temperature, gas composition suggest a final utilisation for feedstock recycling. The low organic content of solid residue does not suggest any other exploitation of the char apart from the land filling. [Italian] La possibilita' di usare il CDR (combustibile derivato dai rifiuti) per produrre gas combustibile, sembra particolarmente promettente e particolare attenzione si sta rivolgendo a tecnologie alternative di trattamento termico, quali la pirolisi e la gassificazione. In questo ambito, il presente lavoro riporta le prove sperimentali e i risultati ottenuti in una campagna di prove di gassificazione di CDR con vapor d'acqua, effettuate su scala banco in un forno a tamburo rotante a temperatura di processo variabile, utilizzando tecniche di analisi termogravimetrica (TG) e di spettrometria infrarossa in trasformata di Fourier (FTIR), per la caratterizzazione del materiale di ingresso, e analisi gascromatografiche on

  3. Effectiveness of Integration and Re-Integration into Work Strategies for Persons with Chronic Conditions: A Systematic Review of European Strategies

    Directory of Open Access Journals (Sweden)

    Carla Sabariego

    2018-03-01

    Full Text Available Due to low employment rates associated to chronic conditions in Europe, it is essential to foster effective integration and re-integration into work strategies. The objective of this systematic review is to summarize the evidence on the effectiveness of strategies for integration and re-integration to work for persons with chronic diseases or with musculoskeletal disorders, implemented in Europe in the past five years. A systematic search was conducted in MedLine, PsycINFO, CDR-HTA, CDR-DARE and Cochrane Systematic Reviews. Overall, 32 relevant publications were identified. Of these, 21 were considered eligible after a methodological assessment and included. Positive changes in employment status, return to work and sick leave outcomes were achieved with graded sickness-absence certificates, part-time sick leave, early ergonomic interventions for back pain, disability evaluation followed by information and advice, and with multidisciplinary, coordinated and tailored return to work interventions. Additionally, a positive association between the co-existence of active labour market policies to promote employment and passive support measures (e.g., pensions or benefits and the probability of finding a job was observed. Research on the evaluation of the effectiveness of strategies targeting integration and re-integration into work for persons with chronic health conditions needs, however, to be improved and strengthened.

  4. Effectiveness of Integration and Re-Integration into Work Strategies for Persons with Chronic Conditions: A Systematic Review of European Strategies.

    Science.gov (United States)

    Sabariego, Carla; Coenen, Michaela; Ito, Elizabeth; Fheodoroff, Klemens; Scaratti, Chiara; Leonardi, Matilde; Vlachou, Anastasia; Stavroussi, Panayiota; Brecelj, Valentina; Kovačič, Dare S; Esteban, Eva

    2018-03-19

    Due to low employment rates associated to chronic conditions in Europe, it is essential to foster effective integration and re-integration into work strategies. The objective of this systematic review is to summarize the evidence on the effectiveness of strategies for integration and re-integration to work for persons with chronic diseases or with musculoskeletal disorders, implemented in Europe in the past five years. A systematic search was conducted in MedLine, PsycINFO, CDR-HTA, CDR-DARE and Cochrane Systematic Reviews. Overall, 32 relevant publications were identified. Of these, 21 were considered eligible after a methodological assessment and included. Positive changes in employment status, return to work and sick leave outcomes were achieved with graded sickness-absence certificates, part-time sick leave, early ergonomic interventions for back pain, disability evaluation followed by information and advice, and with multidisciplinary, coordinated and tailored return to work interventions. Additionally, a positive association between the co-existence of active labour market policies to promote employment and passive support measures (e.g., pensions or benefits) and the probability of finding a job was observed. Research on the evaluation of the effectiveness of strategies targeting integration and re-integration into work for persons with chronic health conditions needs, however, to be improved and strengthened.

  5. Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation.

    Science.gov (United States)

    Bryson, Steve; Thomson, Christy A; Risnes, Louise F; Dasgupta, Somnath; Smith, Kenneth; Schrader, John W; Pai, Emil F

    2016-06-01

    The human Ab response to certain pathogens is oligoclonal, with preferred IgV genes being used more frequently than others. A pair of such preferred genes, IGVK3-11 and IGVH3-30, contributes to the generation of protective Abs directed against the 23F serotype of the pneumonococcal capsular polysaccharide of Streptococcus pneumoniae and against the AD-2S1 peptide of the gB membrane protein of human CMV. Structural analyses of Fab fragments of mAbs 023.102 and pn132p2C05 in complex with portions of the 23F polysaccharide revealed five germline-encoded residues in contact with the key component, l-rhamnose. In the case of the AD-2S1 peptide, the KE5 Fab fragment complex identified nine germline-encoded contact residues. Two of these germline-encoded residues, Arg91L and Trp94L, contact both the l-rhamnose and the AD-2S1 peptide. Comparison of the respective paratopes that bind to carbohydrate and protein reveals that stochastic diversity in both CDR3 loops alone almost exclusively accounts for their divergent specificity. Combined evolutionary pressure by human CMV and the 23F serotype of S. pneumoniae acted on the IGVK3-11 and IGVH3-30 genes as demonstrated by the multiple germline-encoded amino acids that contact both l-rhamnose and AD-2S1 peptide. Copyright © 2016 by The American Association of Immunologists, Inc.

  6. An Approach to Tailoring Major Technical Reviews Based on Project Characteristics and Stakeholder Interests

    Science.gov (United States)

    Richstein, Alan B.; Nolte, Jerome T.; Pfarr, Barbara B.

    2004-01-01

    There are numerous technical reviews that occur throughout the systems engineering process life cycle. Many are well known by project managers and stakeholders such as developers and end users, an example of much is the critical design review (CDR). This major milestone for a large, complex new project may last two or more days, include an extensive agenda of topics, and entail hundreds of hours of developer time to prepare presentation materials and associated documents. Additionally, the weeks of schedule spent on review preparation is at least partly at the expense of other work. This paper suggests an approach for tailoring technical reviews, based on the project characteristics and the project manager s identification of the key stakeholders and understanding of their most important issues and considerations. With this insight the project manager can communicate to, manage expectations oc and establish formal agreement with the stakeholders as to which reviews, and at what depth, are most appropriate to achieve project success. The authors, coming from diverse organizations and backgrounds, have drawn on their personal experiences and summarized the best practices of their own organizations to create a common framework to provide guidance on the adaptation of design reviews to other system engineers.

  7. Community Visions for the Paducah Gaseous Diffusion Plant Site

    Energy Technology Data Exchange (ETDEWEB)

    Ormsbee, Lindell e [Civil Engineering, Univ. of KY; Kipp, James A [Univ. of KY, Kentucky water research Institute

    2011-09-01

    This report focuses on assessing community preferences for the future use of the PGDP site, given the site's pending closure by US DOE. The project approach fostered interaction and engagement with the public based on lessons learned at other complex DOE environmental cleanup sites and upon the integration of a number of principles and approaches to public engagement from the Project Team's local, state, regional and international public engagement experience. The results of the study provide the community with a record of the diversity of values and preferences related to the environmental cleanup and future use of the site.

  8. Paducah Gaseous Diffusion Plant site environmental report for 1988

    International Nuclear Information System (INIS)

    Rogers, J.G.; Jett, T.G.

    1989-05-01

    Quantities of nonradiological chemical emissions are not included in this report this year. An addendum that will include the information will be published after the Superfund Amendments Reauthorization Act (SARA) Title III report is issued on July 1, 1989. When the addendum is published, probably in late July, a summary of the SARA Title III 313 report will be included. The SARA report provides the community with the opportunity to lean about estimated quantities of certain toxic chemicals used at a facility that are routinely or accidentally released into the environment. The addendum that will be published after the SARA report will summarize the SARA report and is expected to include some additional ''large quantity'' chemicals used or stored at the facilities that are not required to be reported by SARA Title III but are known to be emitted from the facilities. The addendum will not be all inclusive but will provide emissions information on the major chemical emissions to the air, water, or land from processes at the facilities

  9. Final report. Paducah Gaseous Diffusion Plant PCB sediment survey: Big Bayou Creek and Little Bayou Creek, Paducah, Kentucky

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-12-01

    Laboratory analysis of collected samples along drainage features at PGDP. Report documents levels of PCB contamination and considers locations of contamination and known releases to theorize probable sources to further investigate.

  10. Lessons Learned from Independent Technical Reviews of U.S. Department of Energy Low-Level Radioactive Waste Landfills/Disposal Facilities

    International Nuclear Information System (INIS)

    Adams, V.; Gupta, D.C.; Smegal, J.S.

    2009-01-01

    This paper describes the lessons learned from a series of independent technical reviews (ITRs) of waste management operations conducted at existing and proposed low-level radioactive waste landfills/disposal facilities at U.S. Department of Energy (DOE) sites. The evaluated waste disposal programs include those at Hanford, Idaho, Savannah River Site, Oak Ridge, Portsmouth, Paducah, and the Nevada Test Site. Based on these evaluations, cost-effective lessons learned were identified to improve reliability and effectiveness of DOE on-site disposal facilities. Key recommendations covered a wide range of issues, including the following: complex-wide applied research effort is needed to evaluate settlement behavior of DOE wastes and how they may affect cover performance; there is a need for unbiased assessment of relevance of liners for different climates and wastes to evaluate where and when liners should be used; there is a need to develop information to demonstrate attenuation capability of modern liner materials and to understand the attenuation capability of liners during performance assessment; a review of historical data on demolition volumes and logistics from past DOE projects can provide valuable insight that can be helpful in planning capacity of future on-site disposal facilities; and operating procedures need to be reviewed and updated on a regular basis so that procedures remain consistent with changes in requirements and take advantage of improvements in technology. The complex-wide independent reviews have assisted DOE sites in considering lessons learned regarding common technical, regulatory, and management issues. Facility management and their operating contractors have begun implementing the applicable recommendations within the context of the DOE Order 435.1, Radioactive Waste Management. (authors)

  11. MJZ VOL 37 NO 2.CDR

    African Journals Online (AJOL)

    MJZ

    taking ART. In both years, 63-73% of medical inpatients were HIV-infected and 98.5% of inpatients agreed to testing. On-the-ward testing in. 2006 avoided the 2003 problem of patient discharge before learning ... adult inpatient aged >17 years old admitted to the medical .... benefits of diagnosis (i.e., use of ART) for the sick.

  12. JUNE NJCP 2009 FINAL sp.cdr

    African Journals Online (AJOL)

    User

    cyst formation with reduction in food intake, aspirations and external surgical drainage; while the .... of clear-coloured salivary fluid via an opening in the ... for exploration, the mandibular fracture was fixed .... International Journal of Pediatric.

  13. nvj 36 1 new.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    physiology, nutrition, endocrinology, pathology, embryology, reproduction and immunology (Tilgar et al., 2008; Vatsalya and. Arora, 2011). Infectious Bursal Disease (IBD) is a highly contagious immunosuppressive disease. (Kasanga et al., 2008). Chickens between 3 and. 6 weeks of age are most susceptible to IBD virus.

  14. TJOG Vol 25 No 2.cdr

    African Journals Online (AJOL)

    and neonatal periods probably due to high levels of maternal Human Chorionic. Results. 3. The total ... Yolksac tumour. 2. Ovary. 5.0. Sertoli Leydig cell tumour. 1. Ovary. 2.5. Adenocarcinoma. 1. Cervix. 2.5. Kaposis sarcoma. 1. Cervix. 2.5. Leiomyoma. 2. Uterus. 5.0. Table 1: Reproductive Tract Tumour Types in Children & ...

  15. nvj 36 2 new.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    ABSTRACT. A survey on gastrointestinal parasites of intensively managed rodents was conducted between December2012 and November 2013 at two tertiary institutions in Ibadan, Nigeria. Samples werecollected from 246 rodents comprising 100 brown field rats (Rattusnorvegicus), 100 grasscutters( ...

  16. DECEMBER JMBR 13 - 2 correction.cdr

    African Journals Online (AJOL)

    Fine Print

    case report is to create awareness on this disorder and its treatment outcome. The patient is a .... In Mood disorder with psychotic symptom, delusion of having HIV/AIDS may occur. But the ... the patient at risk of violence, suicide or homicide.

  17. TJOG Vol 25 No 2.cdr

    African Journals Online (AJOL)

    Although hysterectomy is a common pregnancies, induced abortions and births procedure and well ... Attempts at termination of pregnancy are self worth as a woman because it is an end to embarked .... Key Words:Hysterectomy, Adolescents, Teenagers, Sexuality Education. Correspondence: Dr. C. I. Akani. Department Of ...

  18. nvj 34 4 corrected.cdr

    African Journals Online (AJOL)

    dry and dusty West Africantrade wind that fragility test were carried out using blows from the Sahara desert .... each day of blood collection, 5 ml of blood during this period when the ambient was obtained from each goat, .... transported by road for short-term oxidative damage to several tissues. d u r a t i o n d u r i n g t h e.

  19. RJHS V2(3).cdr

    African Journals Online (AJOL)

    Abe Olugbenga

    diabetics, macrovascular benefits have only been clearly seen in type 1 diabetics ... Keywords Glycemic control· Hyperglycemia· Type 2 diabetes·Glucose .... as the American Diabetes Association (ADA) ..... Endocrinology position statement on.

  20. 3(2) Supplement.cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    Objective:The aims and objective of University Education are well ... The contributions of all stakeholders-the Academic and Non-Teaching Staff;Students, Parents ... Methods: The structure and the design of the university administration system have .... leadership in the faculty and acts as .... positive learning experience.

  1. JUNE 2010.for Ogidi (final).cdr

    African Journals Online (AJOL)

    User

    and creatinine, urinalysis, liver function test and intravenous urography were normal. Apart from her packed cell volume of ... of epithelial ovarian tumours accounting for approximately 10-20% of these neoplasia . About 75 ... Heinemann Educational Books (Nig.) Plc;. 2006: 197-217. Benign and malignant ovarian masses.

  2. TJOG Vol 26 No 1.cdr

    African Journals Online (AJOL)

    Objectives: To determine pregnancy outcomes and microbial organisms in .... urinary tract infection giving an asymptomatic abdominal/uterine tenderness and foul smelling bacteriuria rate of 42.3%. lochia. .... expect of expectant management.

  3. 2010 SEPTEMBER EDITION FINAL.cdr

    African Journals Online (AJOL)

    abnormal behavior, focal seizures and weakness of ... in size and reacted briskly to bright pen torch light. ... detection and treatment could prevent long-term sequelae such as focal neurologic ... signs, convulsions and focal neurologic deficits.

  4. Ujah (Vol. 8 No. 2).cdr

    African Journals Online (AJOL)

    user

    relationship between Tradition and Talent and how each feeds ... something dynamic and something which lives and grows. In ... music therefore, as in all creative activities, the musician or .... achieve because 'performance is a creative activity and the ... 'You and I will live as one' is a popular traditional song that tells.

  5. TJOG Vol 26 No 2.cdr

    African Journals Online (AJOL)

    modern world . point in Obstetric practice in developing countries. It shows the greatest discrepancy. Nigeria, though constituting less than 1% of the between developed and developing countries. 1,2 with regards to WHO health indices . While 25% world's total population, contributes of females of reproductive age live in ...

  6. NJP Number 39 Vol 1, 2012.cdr

    African Journals Online (AJOL)

    Prof Ezechukwu

    Nigerian Journal of Paediatrics 2012;39(1): 14 - 17. Prevalence and pattern of sleep disorder among children with neurological diseases in University of Benin Teaching. Hospital, Benin City, Nigeria. Children were judged to have sleep disorder if the symptom were present frequently or very frequently. Variables were.

  7. nvj 34 4 corrected.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    INTRODUCTION. The rabbit has been bred for several purposes inclusive of which are: as a source of cholesterol-free animal protein; as a domestic pet; and as a laboratory animal ..... (2010): Evaluation of xylazine, acepromazine and medetomidine with ketamine for general anaesthesia in rabbits. Scand. J. Lab Anim.

  8. 3(2) Supplement.cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    used to determine the proximate chemical composition while atomic .... groundnuts flours, soya bean grains, white ... highest protein content (4.69%) while UYM ... O. Iron content was highest (72 mg/100 g) in ... wheat, sorghum and millet (9).

  9. RJHS V2(2).cdr

    African Journals Online (AJOL)

    Abe Olugbenga

    projected to increase to 552million by 2030), and is undoubtedly one of the ... Diabetes exerts a significant burden in sub-Saharan Africa, ... highest mortality rates due to diabetes. The first step ..... Singapore Med J. 2002;43:128–34. 16. Cullen KW ...

  10. TJOG Vol 25 No 1.cdr

    African Journals Online (AJOL)

    All the students knew about the disease getting most of their information from television (31.7%) and radio (27.2%).The aetiological agent of HIV/AIDS was known by 76.3% of the students while blood test was correctly identified as the best method of diagnosis. Only 49.8% mentioned the condom as a method of prevention .

  11. 3(2) Supplement.cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    Web is defined by the Dictionary of Science as: “a hypermedia system…that allows users to view and ... plus the addition of library holdings (number of volumes). ... This ranking system utilizes a .... impact, a virtual referendum among third-.

  12. Res Sep 2013 Cover Tp.cdr

    Indian Academy of Sciences (India)

    Admin

    1885–1977). ISSN 0971-8044. Regn No.KRNA/BGE-340/2012-2014. Licenced to Post without prepayment No.6. Posted at MBC, GPO, Bangalore 560 001, 12.09.13. Registered with Registrar of Newspapers in India vide Regn. No. 66273/96.

  13. IJS v10 n1.cdr

    African Journals Online (AJOL)

    De Don

    2-dicarbonyl derivatives under different reaction conditions) have been reported to show various biological properties. The quinoxaline ring system has been described as bioisoster of aromatic rings, including quinoline, naphthalene,.

  14. nvj 34 4 corrected.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    Brommer et al, 2001) Errors that affect the results of biochemical tests may be ... pH. Total protein and albumin. Vitamins. Lactate. Aminotransferases. (ALT and ... inappropriate container, handling, storage ... undetected failure in quality control) or.

  15. nvj 34 4 corrected.cdr

    African Journals Online (AJOL)

    GRAPHICS DEPT

    rhonchi, cough, arrhythmias, bradycardia, tachycardia, etc (The Merck Veterinary. Manual, 1991). Thoracic radiographs are helpful in the diagnosis of heart disease especially when radiographic findings are compared with results of other diagnostic modalities. Various measurement methods have been reported but none of ...

  16. DECEMBER JMBR 13 - 2 correction.cdr

    African Journals Online (AJOL)

    Fine Print

    control group and others were fed on feed mash (Growers) and water ad libitum. The saline group had physiological saline ... water only ad libitum throughout the duration of experiment before sacrifice at the end of the .... 5. Richburg, J. H and Boekelheide, K. Mono-(2- ethylhexyl) Phthalate Rapidly Alters both Sertoli.

  17. Oladipo and Ayo-Ayinde (7).cdr

    African Journals Online (AJOL)

    Timothy Ademakinwa

    Result also reveals that simple hooked bicellular and unicellular non glandular trichome is diagnostic of Commelinabenghalensisand Aneilema aequinoctialerespectively. Similarities exist in foliar epidermal characters like the trichome and stomata types among other characters between the genera Commelina and ...

  18. Legon Journal of the Humanitie_2.cdr

    African Journals Online (AJOL)

    user

    1Micah Corum is a research fellow in Linguistic Diversity Management in. Urban Areas, Universität .... in various forms in Afro-Caribbean creole languages, Philippine. Creole Spanish ...... d? koti kam, bat ì no si nob? di f? di. DET [police] come ...

  19. NJS July - Dec 2010.cdr (cynt...

    African Journals Online (AJOL)

    NAM

    University of Nigeria Teaching. Hospital ... attract adequate medical manpower in most developing countries. As a result, ... In this study, we examined the factors influencing choice of future career by .... intellectual stimulation and future patient.

  20. RJHS 3(4b).cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    beliefs regarding HIV strongly influence stigma and discrimination ... Cultural issues (gender inequality, ignorance, mis-information) ... pregnant women in rural India showed that 85% of respondents ..... Research in Malaysia. AIDS Care 2006 ...

  1. JUNE ISSUE 2008 FINAL.cdr

    African Journals Online (AJOL)

    birth and 40 weeks post conception, growth rates for different gestational age groups were 129 to 207g/week. (weight) ... half of intra-uterine life, there is a rapid weight gain especially in ... increase is accounted for by an increase in size and.

  2. NJB VOL.34 Original Lower.cdr

    African Journals Online (AJOL)

    rhizosphere heterotrophic population, nitrogen fixing bacteria and enzyme activity of an ... decomposition to reduce its organic strength and degrade its toxic fractions. It was then .... POME samples were collected in clean plastic reduction of 2 ...

  3. TJOG Vol 26 No 1.cdr

    African Journals Online (AJOL)

    Perinatal Outcomes of Rural Population of South Africa. 1. 2. 3. 4. Monjurul ..... population such as poverty and high rate of HIV. 25 infection. ... Low birth weight delivery rates though remained antenatal ... World Health Organization. Health and ...

  4. JMBR VOLUME 14 Number 2.cdr

    African Journals Online (AJOL)

    FINEPRINT

    2. ABSTRACT. Background: Improving reproductive health of young women in least developed ... the primary decision-makers on family size and their ... contributes to improved health outcomes .... educational attainment, wealth and fertility.

  5. 3(2) NEW.cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    Methods: A cross-sectional survey was conducted among patients attending the endocrine clinic of Ekiti ... complications of diabetes mellitus. Among patients with type 1 diabetes mellitus, it has .... Malaysia (7); 64.6% in a Chinese study (8).

  6. DECEMBER JMBR 13 - 2 correction.cdr

    African Journals Online (AJOL)

    Fine Print

    J. E. ATAMAN, D. BAXTER-GRILLO, A.A.A. OSINUBI largely influenced by hormonal factor. Gonadotropin-releasing hormone (GnRH) from the hypothalamus, which is released in pursatile manner, stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) release from the anterior. 4 pituitary. They both ...

  7. DECEMBER JMBR 13 - 2 correction.cdr

    African Journals Online (AJOL)

    Fine Print

    , there is need to define the ... analysed using simple descriptive statistics. .... hormones in African-Americans compared to. 11 ... Our study showed three peak ... lesser mortality compared to ductal ... –positive or hormone receptor negative.

  8. JUNE NJCP 2009 FINAL sp.cdr

    African Journals Online (AJOL)

    User

    Methods. Results: Conclusion. Departments of *Surgery and **Morbid ... heightened in developing countries due to limited diagnostic and therapeutic ... disease in our population, albeit from a hospital .... musculoskeletal tumours in Nigeria. Int.

  9. RJHS Vol 4(1).cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    postmenopausal women associated with a decreased body image and quality of life. ... 1Department of Obstetrics And Gynaecology, Bowen University Teaching Hospital, Ogbomosho, ... Awotunde OT . , Fehintola AO. , Ogunlaja OA. , Olujide LO. , Aaron OI. , Bakare B . , .... stress of multiple unsupervised vaginal deliveries.

  10. 1. REACHING THE UNREACHED.cdr

    African Journals Online (AJOL)

    RICHY

    including attention to care givers or parental concerns. ... and not involving them in decisions about immunisation. But now, most of .... decision making and explore any specific concerns ... Ley P, Improving patients' understanding, recall, nd.

  11. IJS v10 n1.cdr

    African Journals Online (AJOL)

    De Don

    group consisting of 30 individuals was studied using the constant animal group follow method carried out for consecutive fifteen days each month. The animal species frequently observed with the olive baboons were the black and white colobus ... of the diversity of social behaviour shown by primates and its importance in ...

  12. RJHS 3(4b).cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    2013-08-08

    Aug 8, 2013 ... respondents had an accident at the workplace while 4% had injury, 60% had ... Department of Community Health, Federal Medical Centre, Owo, Ondo State, Nigeria. Res. ... fluids is a common problem among health care.

  13. RJHS 3(4b).cdr

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    provided, had no access to mass media, had more children and had ... drug addiction and has been found to be an effective method of .... worship places and social groups to re-enforce ... They were called on phone a week before the monthly ...

  14. 2012 edition JMBR - CORRECTION.cdr

    African Journals Online (AJOL)

    FinePrint

    Cataract and uncorrected refractive errors were reported to be the ... cataract cases are often age related, with ... School of Optometry, Faculty of Medicine ... have reduced the risk of blindness after eye ... major problem of cataract surgery. This.

  15. JMBR VOLUME 14 Number 2.cdr

    African Journals Online (AJOL)

    FINEPRINT

    Acute poisoning with typically HgCl 2 generally targets ... abdominal pain, vomiting, and bloody diarrhoea with ... concomitant occupational exposure to mercury ... activity of superoxide dismutase, catalase ..... Acetylcholinesterase Inhibitory,.

  16. 2010 SEPTEMBER EDITION FINAL.cdr

    African Journals Online (AJOL)

    haematuria. The diagnosis is mainly from the history of cyclical haematuria following a lower segment caesarean section, clinical evaluation, high index of suspicion and a simple investigation and confirmation at operation. The treatment of a vesico-uterine fistula is. 3 by surgical repair , preferably in conjunction with a.

  17. TJOG Vol 25 No 1.cdr

    African Journals Online (AJOL)

    where my father also studied medicine. an array of good ... a difference to the lives of women in Ibadan, to qualify for an .... weapon to our Safe Motherhood armory. ward and put all the ... fill this glaring and yawning gap in public forgetting its ...

  18. TJOG Vol 25 No 1.cdr

    African Journals Online (AJOL)

    places of delivery were government facilities (54.8%), private hospital (24.5%), traditional birth attendants ... public health institutions will encourage women to use the available maternity services. ... At the Safe Motherhood Initiative (SMI).

  19. 2012 edition JMBR - CORRECTION.cdr

    African Journals Online (AJOL)

    FinePrint

    Boehringer spectrophometer 4010) at appropriate wavelengths. The concentration of plasma low density lipoprotein cholesterol (LDLc) was. 1 estimated according to Okwusidi (1988) as the difference between TPC and HDLc to obtain summed LDLc + VLDLc; with subsequent adjustment for determined. TRG concentration ...

  20. 37(4) All.cdr

    African Journals Online (AJOL)

    HP

    Department of Veterinary Surgery and Theriogenology, Faculty of Veterinary Medicine, University of Maiduguri,. Nigeria. Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria. Veterinary Teaching Hospital, University of Maiduguri. Department of Pathology and Microbiology ...