Sample records for cbne detection microsystem

  1. Viral RNA testing and automation on the bead-based CBNE detection microsystem.

    Energy Technology Data Exchange (ETDEWEB)

    Galambos, Paul C.; Bourdon, Christopher Jay; Farrell, Cara M.; Rossito, Paul (University of California at Davis); McClain, Jaime L.; Derzon, Mark Steven; Cullor, James Sterling (University of California at Davis); Rahimian, Kamayar


    We developed prototype chemistry for nucleic acid hybridization on our bead-based diagnostics platform and we established an automatable bead handling protocol capable of 50 part-per-billion (ppb) sensitivity. We are working towards a platform capable of parallel, rapid (10 minute), raw sample testing for orthogonal (in this case nucleic acid and immunoassays) identification of biological (and other) threats in a single sensor microsystem. In this LDRD we developed the nucleic acid chemistry required for nucleic acid hybridization. Our goal is to place a non-cell associated RNA virus (Bovine Viral Diarrhea, BVD) on the beads for raw sample testing. This key pre-requisite to showing orthogonality (nucleic acid measurements can be performed in parallel with immunoassay measurements). Orthogonal detection dramatically reduces false positives. We chose BVD because our collaborators (UC-Davis) can supply samples from persistently infected animals; and because proof-of-concept field testing can be performed with modification of the current technology platform at the UC Davis research station. Since BVD is a cattle-prone disease this research dovetails with earlier immunoassay work on Botulinum toxin simulant testing in raw milk samples. Demonstration of BVD RNA detection expands the repertoire of biological macromolecules that can be adapted to our bead-based detection. The resources of this late start LDRD were adequate to partially demonstrate the conjugation of the beads to the nucleic acids. It was never expected to be adequate for a full live virus test but to motivate that additional investment. In addition, we were able to reduce the LOD (Limit of Detection) for the botulinum toxin stimulant to 50 ppb from the earlier LOD of 1 ppm. A low LOD combined with orthogonal detection provides both low false negatives and low false positives. The logical follow-on steps to this LDRD research are to perform live virus identification as well as concurrent nucleic acid and

  2. Differential thermal analysis microsystem for explosive detection

    DEFF Research Database (Denmark)

    Olsen, Jesper Kenneth; Greve, Anders; Senesac, L.


    A micro differential thermal analysis (DTA) system is used for detection of trace explosive particles. The DTA system consists of two silicon micro chips with integrated heaters and temperature sensors. One chip is used for reference and one for the measurement sample. The sensor is constructed...... as a small silicon nitride membrane incorporating heater elements and a temperature measurement resistor. In this manuscript the DTA system is described and tested by measuring calorimetric response of 3 different kinds of explosives (TNT, RDX and PETN). This project is carried out under the framework...

  3. Microsystem strategies for sample preparation in biological detection.

    Energy Technology Data Exchange (ETDEWEB)

    James, Conrad D.; Galambos, Paul C.; Bennett, Dawn Jonita (University of Maryland Baltimore County, Baltimore, MD); Manginell, Monica; Okandan, Murat; Acrivos, Andreas (The City College of New York, NY); Brozik, Susan Marie; Khusid, Boris (New Jersey Institute of Technology, Newark, NJ)


    The objective of this LDRD was to develop microdevice strategies for dealing with samples to be examined in biological detection systems. This includes three sub-components: namely, microdevice fabrication, sample delivery to the microdevice, and sample processing within the microdevice. The first component of this work focused on utilizing Sandia's surface micromachining technology to fabricate small volume (nanoliter) fluidic systems for processing small quantities of biological samples. The next component was to develop interfaces for the surface-micromachined silicon devices. We partnered with Micronics, a commercial company, to produce fluidic manifolds for sample delivery to our silicon devices. Pressure testing was completed to examine the strength of the bond between the pressure-sensitive adhesive layer and the silicon chip. We are also pursuing several other methods, both in house and external, to develop polymer-based fluidic manifolds for packaging silicon-based microfluidic devices. The second component, sample processing, is divided into two sub-tasks: cell collection and cell lysis. Cell collection was achieved using dielectrophoresis, which employs AC fields to collect cells at energized microelectrodes, while rejecting non-cellular particles. Both live and dead Staph. aureus bacteria have been collected using RF frequency dielectrophoresis. Bacteria have been separated from polystyrene microspheres using frequency-shifting dielectrophoresis. Computational modeling was performed to optimize device separation performance, and to predict particle response to the dielectrophoretic traps. Cell lysis is continuing to be pursued using microactuators to mechanically disrupt cell membranes. Novel thermal actuators, which can generate larger forces than previously tested electrostatic actuators, have been incorporated with and tested with cell lysis devices. Significant cell membrane distortion has been observed, but more experiments need to be

  4. Portable microsystem integrates multifunctional dielectrophoresis manipulations and a surface stress biosensor to detect red blood cells for hemolytic anemia. (United States)

    Sang, Shengbo; Feng, Qiliang; Jian, Aoqun; Li, Huiming; Ji, Jianlong; Duan, Qianqian; Zhang, Wendong; Wang, Tao


    Hemolytic anemia intensity has been suggested as a vital factor for the growth of certain clinical complications of sickle cell disease. However, there is no effective and rapid diagnostic method. As a powerful platform for bio-particles testing, biosensors integrated with microfluidics offer great potential for a new generation of portable point of care systems. In this paper, we describe a novel portable microsystem consisting of a multifunctional dielectrophoresis manipulations (MDM) device and a surface stress biosensor to separate and detect red blood cells (RBCs) for diagnosis of hemolytic anemia. The peripheral circuit to power the interdigitated electrode array of the MDM device and the surface stress biosensor test platform were integrated into a portable signal system. The MDM includes a preparing region, a focusing region, and a sorting region. Simulation and experimental results show the RBCs trajectories when they are subjected to the positive DEP force, allowing the successful sorting of living/dead RBCs. Separated RBCs are then transported to the biosensor and the capacitance values resulting from the variation of surface stress were measured. The diagnosis of hemolytic anemia can be realized by detecting RBCs and the portable microsystem provides the assessment to the hemolytic anemia patient.

  5. Microsystem Interfaces for Space



    Microsystem interfaces to the macroscopic surroundings and within the microsystems themselves are formidable challenges that this thesis makes an effort to overcome, specifically for enabling a spacecraft based entirely on microsystems. The NanoSpace-1 nanospacecraft is a full-fledged satellite design with mass below 10 kg. The high performance with respect to mass is enabled by a massive implementation of microsystem technology – the entire spacecraft structure is built from square silicon p...

  6. Microsystem Aeromechanics Wind Tunnel (United States)

    Federal Laboratory Consortium — The Microsystem Aeromechanics Wind Tunnel advances the study of fundamental flow physics relevant to micro air vehicle (MAV) flight and assesses vehicle performance...

  7. A giant magnetoresistance ring-sensor based microsystem for magnetic bead manipulation and detection

    KAUST Repository

    Gooneratne, Chinthaka P.


    In this paper a novel spin valvegiant magnetoresistance(GMR) ring-sensor integrated with a microstructure is proposed for concentrating, trapping, and detecting superparamagnetic beads (SPBs). Taking advantage of the fact that SPBs can be manipulated by an external magnetic field, a unique arrangement of conducting microrings is utilized to manipulate the SPBs toward the GMR sensing area in order to increase the reliability of detection. The microrings are arranged and activated in such a manner so as to enable the detection of minute concentrations of SPBs in a sample. Precise manipulation is achieved by applying current sequentially to the microrings. The fabricated ring-shaped GMR element is located underneath the innermost ring and has a magnetoresistance of approximately 5.9%. By the performed experiments it was shown that SPBs could be successfully manipulated toward the GMR sensing zone.

  8. Chromatographic air analyser microsystem for the selective and sensitive detection of atmospheric pollutants

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, Jean-Baptiste; Lahlou, Houda; Mohsen, Yehya; Berger, Franck [Laboratoire de Chimie Physique et Rayonnements, Alain Chambaudet, UMR CEA E4 UFR ST, Universite de Franche Comte, 25000 Besancon (France); Vilanova, Xavier; Correig, Xavier, E-mail: [Departament d' Enginyeria Electronica, Electrica i Automatica, Universitat Rovira i Virgili, Paisos Catalans 26, 43007, Tarragona (Spain)


    The development of industry and automotive trafic produces Volatile Organic Compounds (VOCs) whose toxicity can affect seriously human health and environment. The level of those contaminants in air must be as low as possible. In this context, there is a need for in situ systems that could monitor selectively the concentration of these compounds. The aim of this study is to demonstrate the efficiency of a system build with a pre-concentrator, a chromatographic micro-column and a tin oxide-based gas sensor for the selective and sensitive detection of atmospheric pollutants. In particular, this study is focused on the selective detection of benzene and 1,3 butadiene.

  9. Portable microsystem integrates multifunctional dielectrophoresis manipulations and a surface stress biosensor to detect red blood cells for hemolytic anemia


    Shengbo Sang; Qiliang Feng; Aoqun Jian; Huiming Li; Jianlong Ji; Qianqian Duan; Wendong Zhang; Tao Wang


    Hemolytic anemia intensity has been suggested as a vital factor for the growth of certain clinical complications of sickle cell disease. However, there is no effective and rapid diagnostic method. As a powerful platform for bio-particles testing, biosensors integrated with microfluidics offer great potential for a new generation of portable point of care systems. In this paper, we describe a novel portable microsystem consisting of a multifunctional dielectrophoresis manipulations (MDM) devic...

  10. Continuous flow analytical microsystems based on low-temperature co-fired ceramic technology. Integrated potentiometric detection based on solvent polymeric ion-selective electrodes. (United States)

    Ibanez-Garcia, Nuria; Mercader, Manel Bautista; Mendes da Rocha, Zaira; Seabra, Carlos Antonio; Góngora-Rubio, Mario Ricardo; Chamarro, Julian Alonso


    In this paper, the low-temperature co-fired ceramics (LTCC) technology, which has been commonly used for electronic applications, is presented as a useful alternative to construct continuous flow analytical microsystems. This technology enables not only the fabrication of complex three-dimensional structures rapidly and at a realistic cost but also the integration of the elements needed to carry out a whole analytical process, such as pretreatment steps, mixers, and detection systems. In this work, a simple and general procedure for the integration of ion-selective electrodes based on liquid ion exchanger is proposed and illustrated by using ammonium- and nitrate-selective membranes. Additionally, a screen-printed reference electrode was easily incorporated into the microfluidic LTCC structure allowing a complete on-chip integration of the potentiometric detection. Analytical features of the proposed systems are presented.

  11. Electrohydrodynamic pumping in microsystems

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Antonio, E-mail: [Deptartamento de Electronica y Electromagnetismo, Universidad de Sevilla, Avenida Reina Mercedes s/n, 41012-Sevilla (Spain)


    The physical principles behind the electrohydrodynamic (EHD) actuation in microsystems is presented by reviewing five different EHD micropumps. These are classified into two groups: micropumps that exert electric forces in the liquid bulk and micropumps that exert forces in the diffuse double layer. This review of five EHD micropumps allows us to analyse the EHD actuation ranging from very insulating liquids to electrolytic solutions.

  12. Microsystem Cooler Development (United States)

    Moran, Matthew E.; Wesolek, Danielle M.; Berhane, Bruk T.; Rebello, Keith J.


    A patented microsystem Stirling cooler is under development with potential application to electronics, sensors, optical and radio frequency (RF) systems, microarrays, and other microsystems. The microsystem Stirling cooler is most suited to volume-limited applications that require cooling below the ambient or sink temperature. Primary components of the planar device include: two diaphragm actuators that replace the pistons found in traditional-scale Stirling machines; and a micro-regenerator that stores and releases thermal energy to the working gas during the Stirling cycle. The use of diaphragms eliminates frictional losses and bypass leakage concerns associated with pistons, while permitting reversal of the hot and cold sides of the device during operation to allow precise temperature control. Three candidate microregenerators were custom fabricated for initial evaluation: two constructed of porous ceramic, and one made of multiple layers of nickel and photoresist in an offset grating pattern. An additional regenerator was prepared with a random stainless steel fiber matrix commonly used in existing Stirling machines for comparison to the custom fabricated regenerators. The candidate regenerators were tested in a piezoelectric-actuated test apparatus designed to simulate the Stirling refrigeration cycle. In parallel with the regenerator testing, electrostatically-driven comb-drive diaphragm actuators for the prototype device have been designed for deep reactive ion etching (DRIE) fabrication.

  13. Rapid sample preparation for detection and identification of avian influenza virus from chicken faecal samples using magnetic bead microsystem

    DEFF Research Database (Denmark)

    Dhumpa, Raghuram; Bu, Minqiang; Handberg, Kurt;


    Avian influenza virus (AIV) is an infectious agent of birds and mammals. AIV is causing huge economic loss and can be a threat to human health. Reverse transcriptase polymerase chain reaction (RT-PCR) has been used as a method for the detection and identification of AIV virus. Although RT...

  14. Infrastructure for microsystem production (United States)

    van Heeren, Henne; Sanchez, Stefan; Elders, Job; Heideman, Rene G.


    Manufacturing of micro-systems differs from IC manufacturing because the market requires a diversity of products and lower volumes per product. In addition, a diversity of micro-technologies has been developed, including non-IC compatible processes and potentially IC compatible processes. An infrastructure for the production of micro- system devices is lacking. On one side the technology for MST is available at the universities and small university related companies. On the other side there are several small and medium enterprises and bigger companies wanting to implement MST devices in their products, but unwilling to be dependent on universities. Philips Electronics in the Netherlands and Twente MicroProducts realized this problem and have started a project to fill this gap. At this moment the basic of the infrastructure is available: OnStream BV, Eindhoven, The Netherlands, opened its waferfab and assembly facilities for the production of MST devices. Twente MicroProducts will take care of the design of the products and of the small-scale production. Integration of quality systems for maintenance, yield, statistical process control and production in a Manufacturing Execution System offers direct access for all people involved to all the relevant information. It also ensures quality of the products made. The available capabilities of the infrastructure in the current status are compared to the market needs. In this article, a description of a seamless Micro-System Engineering Foundry is given. A seamless organization is capable of helping the customer from design to production. Several examples are given.

  15. Microsystems - The next big thing

    Energy Technology Data Exchange (ETDEWEB)



    Micro-Electro-Mechanical Systems (MEMS) is a big name for tiny devices that will soon make big changes in everyday life and the workplace. These and other types of Microsystems range in size from a few millimeters to a few microns, much smaller than a human hair. These Microsystems have the capability to enable new ways to solve problems in commercial applications ranging from automotive, aerospace, telecommunications, manufacturing equipment, medical diagnostics to robotics, and in national security applications such as nuclear weapons safety and security, battlefield intelligence, and protection against chemical and biological weapons. This broad range of applications of Microsystems reflects the broad capabilities of future Microsystems to provide the ability to sense, think, act, and communicate, all in a single integrated package. Microsystems have been called the next silicon revolution, but like many revolutions, they incorporate more elements than their predecessors. Microsystems do include MEMS components fabricated from polycrystalline silicon processed using techniques similar to those used in the manufacture of integrated electrical circuits. They also include optoelectronic components made from gallium arsenide and other semiconducting compounds from the III-V groups of the periodic table. Microsystems components are also being made from pure metals and metal alloys using the LIGA process, which utilizes lithography, etching, and casting at the micron scale. Generically, Microsystems are micron scale, integrated systems that have the potential to combine the ability to sense light, heat, pressure, acceleration, vibration, and chemicals with the ability to process the collected data using CMOS circuitry, execute an electrical, mechanical, or photonic response, and communicate either optically or with microwaves.

  16. Implantable biomedical microsystems design principles and applications

    CERN Document Server

    Bhunia, Swarup; Sawan, Mohamad


    Research and innovation in areas such as circuits, microsystems, packaging, biocompatibility, miniaturization, power supplies, remote control, reliability, and lifespan are leading to a rapid increase in the range of devices and corresponding applications in the field of wearable and implantable biomedical microsystems, which are used for monitoring, diagnosing, and controlling the health conditions of the human body. This book provides comprehensive coverage of the fundamental design principles and validation for implantable microsystems, as well as several major application areas. Each co

  17. Development of packaging technologies for microsystems

    Institute of Scientific and Technical Information of China (English)

    JIN Yu-feng; WANG Zhen-feng; WEI Jun


    It is well known that packaging plays a very important role in developing microsystems. Packaging accounts for about 60%~80% of cost and function of a microsystem. Package is required to provide mechanical protection, media separation or coupling, signal conditioning, etc.

  18. Optimized microsystems-enabled photovoltaics

    Energy Technology Data Exchange (ETDEWEB)

    Cruz-Campa, Jose Luis; Nielson, Gregory N.; Young, Ralph W.; Resnick, Paul J.; Okandan, Murat; Gupta, Vipin P.


    Technologies pertaining to designing microsystems-enabled photovoltaic (MEPV) cells are described herein. A first restriction for a first parameter of an MEPV cell is received. Subsequently, a selection of a second parameter of the MEPV cell is received. Values for a plurality of parameters of the MEPV cell are computed such that the MEPV cell is optimized with respect to the second parameter, wherein the values for the plurality of parameters are computed based at least in part upon the restriction for the first parameter.

  19. Heterogeneously integrated microsystem-on-a-chip (United States)

    Chanchani, Rajen


    A microsystem-on-a-chip comprises a bottom wafer of normal thickness and a series of thinned wafers can be stacked on the bottom wafer, glued and electrically interconnected. The interconnection layer comprises a compliant dielectric material, an interconnect structure, and can include embedded passives. The stacked wafer technology provides a heterogeneously integrated, ultra-miniaturized, higher performing, robust and cost-effective microsystem package. The highly integrated microsystem package, comprising electronics, sensors, optics, and MEMS, can be miniaturized both in volume and footprint to the size of a bottle-cap or less.

  20. Microsystem Cooler Concept Developed and Being Fabricated (United States)

    Moran, Matthew E.


    A patented microsystem cooler concept has been developed by the NASA Glenn Research Center. It incorporates diaphragm actuators to produce the Stirling refrigeration cycle within a planar configuration compatible with the thermal management of electronics, sensors, optical and radiofrequency systems, microarrays, and other microsystems. The microsystem cooler is most suited to volume-limited applications that require cooling below the ambient or sink temperature. Johns Hopkins University Applied Physics Laboratory is conducting development testing and fabrication of a prototype under a grant from Glenn.

  1. Silicon carbide microsystems for harsh environments

    CERN Document Server

    Wijesundara, Muthu B J


    Silicon Carbide Microsystems for Harsh Environments reviews state-of-the-art Silicon Carbide (SiC) technologies that, when combined, create microsystems capable of surviving in harsh environments, technological readiness of the system components, key issues when integrating these components into systems, and other hurdles in harsh environment operation. The authors use the SiC technology platform suite the model platform for developing harsh environment microsystems and then detail the current status of the specific individual technologies (electronics, MEMS, packaging). Additionally, methods

  2. Small Antennas for Wireless Micro-Systems


    Rainer Wansch


    This paper will describe the topology of wireless micro-systems networks and some of their key components. In particular we will deal with the antennas: loops, helices, F-antennas, patches and dielectrically loaded antennas.

  3. High performance microsystem packaging: A perspective

    Energy Technology Data Exchange (ETDEWEB)

    Romig, A.D. Jr.; Dressendorfer, P.V.; Palmer, D.W.


    The second silicon revolution will be based on intelligent, integrated microsystems where multiple technologies (such as analog, digital, memory, sensor, micro-electro-mechanical, and communication devices) are integrated onto a single chip or within a multichip module. A necessary element for such systems is cost-effective, high-performance packaging. This paper examines many of the issues associated with the packaging of integrated microsystems, with an emphasis on the areas of packaging design, manufacturability, and reliability.

  4. European Master Programs in Nanoelectronics and Microsystems

    DEFF Research Database (Denmark)

    Bruun, Erik; Demarchi, Danilo; Nielsen, Ivan Ring


    Nanotechnology and Microsystems are having increasing impact on university curricula in electrical engineering. The advent of nanotechnology brings about new possibilities in nanoelectronics, including increasingly complex systems on chip, sophisticated technology fusion between electronic device...... been around for a number of years. This paper presents an overview of present European programs in nanoelectronics and Microsystems. Also, the services provided for universities by the EuroTraining program1 are described....

  5. Intelligent agents: adaptation of autonomous bimodal microsystems (United States)

    Smith, Patrice; Terry, Theodore B.


    Autonomous bimodal microsystems exhibiting survivability behaviors and characteristics are able to adapt dynamically in any given environment. Equipped with a background blending exoskeleton it will have the capability to stealthily detect and observe a self-chosen viewing area while exercising some measurable form of selfpreservation by either flying or crawling away from a potential adversary. The robotic agent in this capacity activates a walk-fly algorithm, which uses a built in multi-sensor processing and navigation subsystem or algorithm for visual guidance and best walk-fly path trajectory to evade capture or annihilation. The research detailed in this paper describes the theoretical walk-fly algorithm, which broadens the scope of spatial and temporal learning, locomotion, and navigational performances based on optical flow signals necessary for flight dynamics and walking stabilities. By observing a fly's travel and avoidance behaviors; and, understanding the reverse bioengineering research efforts of others, we were able to conceptualize an algorithm, which works in conjunction with decisionmaking functions, sensory processing, and sensorimotor integration. Our findings suggest that this highly complex decentralized algorithm promotes inflight or terrain travel mobile stability which is highly suitable for nonaggressive micro platforms supporting search and rescue (SAR), and chemical and explosive detection (CED) purposes; a necessity in turbulent, non-violent structured or unstructured environments.

  6. Optical MEMS at Silex Microsystems (United States)

    Rimskog, Magnus; Kaelvesten, Edvard; Svedin, Niklas


    Silex Microsystems produces Silicon Optical Benches and Silicon Optical Mirrors for a variety of customers on an international market. The core of the activity is the MEMS chip itself and the related processes. By qualifying processes Silex provides the opportunity for clients to increase the degree of development in the MEMS cores of their products. The designs are customized in order to meet the specifications for a wide customer base with even wider demands. The Silicon Optical Benches can incorporate BCB layers in order to integrate RF-lines and make it possible to design for example coils of high performance. The polysilicon resistors have been qualified to be stable within 3-ppm over 6 months at elevated temperatures. The polysilicon temperature dependence makes it possible to use the resistors in order to measure temperature and excludes thermistors from the designs. Electrical feed through vias can be incorporated to enable backside connection and simplify packaging. The Silicon Optical Mirrors are produced both as large arrays of small mirrors and smaller arrays of larger mirrors depending on applications. Also for the mirrors the incorporations of electrical vias simplify design and process issues. The pads under the mirrors are connected from backside and it is possible to avoid difficult contacting down in cavities.

  7. pH-Taxis of Biohybrid Microsystems (United States)

    Zhuang, Jiang; Wright Carlsen, Rika; Sitti, Metin


    The last decade has seen an increasing number of studies developing bacteria and other cell-integrated biohybrid microsystems. However, the highly stochastic motion of these microsystems severely limits their potential use. Here, we present a method that exploits the pH sensing of flagellated bacteria to realize robust drift control of multi-bacteria propelled microrobots. Under three specifically configured pH gradients, we demonstrate that the microrobots exhibit both unidirectional and bidirectional pH-tactic behaviors, which are also observed in free-swimming bacteria. From trajectory analysis, we find that the swimming direction and speed biases are two major factors that contribute to their tactic drift motion. The motion analysis of microrobots also sheds light on the propulsion dynamics of the flagellated bacteria as bioactuators. It is expected that similar driving mechanisms are shared among pH-taxis, chemotaxis, and thermotaxis. By identifying the mechanism that drives the tactic behavior of bacteria-propelled microsystems, this study opens up an avenue towards improving the control of biohybrid microsystems. Furthermore, assuming that it is possible to tune the preferred pH of bioactuators by genetic engineering, these biohybrid microsystems could potentially be applied to sense the pH gradient induced by cancerous cells in stagnant fluids inside human body and realize targeted drug delivery.

  8. New EUROPRACTICE microsystem design and foundry services (United States)

    Salomon, Patric R.; Beernaert, Dirk; Turner, Rob


    The microsystems market for MST is predicted to grow to 38 billion dollars by the year 2002, with systems containing these components generating even higher revenues and growth. One of the barriers to successful exploitation of this technology has been the lack of access to industrial foundries capable of producing certified microsystems devices in commercial quantities. To overcome this problem, the European Commission has started the EUROPRACTICE program in 1996 with the installation of manufacturing clusters and demonstration activities to provide access to microsystems foundry services for European small and medium sized companies (SMEs). Since 1996, there has been a shift form providing 'broad technology offers' and 'raising awareness fro microsystem capabilities' to 'direct support of design needs' and 'focused services' which allow SMEs to use even complex microsystems technologies to implement their products, The third phase of EUROPRACTICE has just been launched, and contains 5 Manufacturing Clusters, 12 Designs Houses, and 7 Competence Centers, each working in different application/technology areas. The EUROPRACTICE program will be presented together with a detail description of the capabilities of the participants and information on how to access their services.

  9. Development and Outlook of Wireless Implantable Continuously Intraocular Pressure Detection Microsystems%无线植入式连续眼内压检测微系统发展与展望

    Institute of Scientific and Technical Information of China (English)

    刘德盟; 吴淼; 梅年松; 张钊锋


    The implantable intraocular pressure detection microsystem is a system which can be implanted in eyes to detect intraocular pressure continuously and transmit the signal to outside. The system is summarized according to the research progress of the system in recent years. The principle and development of LC oscillation and SoC structure always used in the system are introduced, and the main technical indexes, fabrication process and existing problems are analyzed. Based on bioelectromagnetics, MEMS technology and IC technology, the development status, existing problems and breakthrough directions of the key technologies such as antenna, circuit system and pressure sensor are analyzed. Then the application level problems such as biological compatibility materials and implant position are summarized and prospected. At last, the development direction of the system is prospected according to the existing problems of the system.%植入式眼压检测微系统是一种植入到眼内进行眼内压连续检测并通过电磁波传输到体外的微系统.根据该系统近些年的研究进展对该系统进行综述,介绍了该系统常采用的LC振荡结构和SoC结构的原理和发展历程,并对其主要技术指标和制作工艺以及存在问题进行论述;结合生物电磁效应、MEMS技术和集成电路技术等,综合分析了SoC系统的天线、电路系统和压力传感器等关键技术的发展现状、存在的问题和突破方向;对生物兼容性材料和植入位置等应用层面进行总结和展望;最后根据对该系统存在问题的总结,对该系统的发展趋势进行展望.

  10. Recent Advances in Neural Recording Microsystems

    Directory of Open Access Journals (Sweden)

    Benoit Gosselin


    Full Text Available The accelerating pace of research in neuroscience has created a considerable demand for neural interfacing microsystems capable of monitoring the activity of large groups of neurons. These emerging tools have revealed a tremendous potential for the advancement of knowledge in brain research and for the development of useful clinical applications. They can extract the relevant control signals directly from the brain enabling individuals with severe disabilities to communicate their intentions to other devices, like computers or various prostheses. Such microsystems are self-contained devices composed of a neural probe attached with an integrated circuit for extracting neural signals from multiple channels, and transferring the data outside the body. The greatest challenge facing development of such emerging devices into viable clinical systems involves addressing their small form factor and low-power consumption constraints, while providing superior resolution. In this paper, we survey the recent progress in the design and the implementation of multi-channel neural recording Microsystems, with particular emphasis on the design of recording and telemetry electronics. An overview of the numerous neural signal modalities is given and the existing microsystem topologies are covered. We present energy-efficient sensory circuits to retrieve weak signals from neural probes and we compare them. We cover data management and smart power scheduling approaches, and we review advances in low-power telemetry. Finally, we conclude by summarizing the remaining challenges and by highlighting the emerging trends in the field.

  11. MEMS & microsystems design, manufacture, and nanoscale engineering

    CERN Document Server

    Hsu, Tai-Ran


    A bestselling MEMS better than ever. An engineering design approach to Microelectromechanical Systems, MEMS and Microsystems remains the only available text to cover both the electrical and the mechanical aspects of the technology. In the five years since the publication of the first edition, there have been significant changes in the science and technology of miniaturization, including microsystems technology and nanotechnology. In response to the increasing needs of engineers to acquire basic knowledge and experience in these areas, this popular text has been carefully updated, including an entirely new section on the introduction of nanoscale engineering. Following a brief introduction to the history and evolution of nanotechnology, the author covers the fundamentals in the engineering design of nanostructures, including fabrication techniques for producing nanoproducts, engineering design principles in molecular dynamics, and fluid flows and heat transmission in nanoscale substances.


    Directory of Open Access Journals (Sweden)

    O. G. Reutskaya


    Full Text Available Manufacture of module of chemical sensors on a single chip is one of the promising directions in the development of gas sensory. The aim of this work was development of construction of multisensor microsystem enabled to retain the characteristics of a single sensor and its dimensions and, at the same time, to reduce power consumption and cycle time of measuring concentration of gases CO, H2 , C3H8 , CO2 in the environment. Multisensor microsystem consists of four detached sensors placed on a single substrate of nanostructured aluminum oxide. The use of through-holes and the dielectric substrate itself in microsystem topology reduced power consumption of gas microsystems. We have devised a method of measuring sensitivity of foursensor microsystem to the concentration of gases CO, H2 , C3H8 , CO2. A full cycle of measuring gases concentration consisted of the time required for preliminary heating of all sensors of the microsystem (5 s, the heating time of each of the sensors sequentially (5 s and time required to measure resistance for each sensor (80 s. The measured results show that the reaction time of multisensor microsystem when exposed to gases – H2 at a concentration of 0,001 %, CO2  1 %, СО – 0,02 %, C3H8 – 0,01 % does not exceed 90 s for full measurement cycle. Sensitivity value at power consumption of < 150 mW makes up 48–64 % for H2 , 32– 36 % for CO2 , 20–29 % for СО, 68–78 % for C3H8 . The proposed method to control sensitivity of multisensor microsystem to the concentration of gases CO, H2 , C3H8 , CO2 allows performing measurements within 90 s while the measurement cycle by a single sensor in pulse heating mode is 2 min, in continuous heat mode – 5 min. Maximum power consumption of the microsystem does not exceed 150 mW. Microsystems allow measuring lower concentrations of detected gases. 

  13. Digital holography for MEMS and microsystem metrology

    CERN Document Server

    Asundi, Anand


    Approaching the topic of digital holography from the practical perspective of industrial inspection, Digital Holography for MEMS and Microsystem Metrology describes the process of digital holography and its growing applications for MEMS characterization, residual stress measurement, design and evaluation, and device testing and inspection. Asundi also provides a thorough theoretical grounding that enables the reader to understand basic concepts and thus identify areas where this technique can be adopted. This combination of both practical and theoretical approach will ensure the

  14. Energy harvesting with functional materials and microsystems

    CERN Document Server

    Bhaskaran, Madhu; Iniewski, Krzysztof


    For decades, people have searched for ways to harvest energy from natural sources. Lately, a desire to address the issue of global warming and climate change has popularized solar or photovoltaic technology, while piezoelectric technology is being developed to power handheld devices without batteries, and thermoelectric technology is being explored to convert wasted heat, such as in automobile engine combustion, into electricity. Featuring contributions from international researchers in both academics and industry, Energy Harvesting with Functional Materials and Microsystems explains the growi

  15. Mechanics of Multifunctional Materials and Microsystems (United States)


    Program on “Mechanics of Multifunctional Materials & Microsystems" 30 July-1 August 2012 Hilton Arlington Hotel , Arlington, VA Workshop Co...automatic fashion 11 FUNCTIONS OF INTEREST Active Regulation Reactive Materials Mesoporous Networks Adaptive Fluids/Solids Self-Regulating Function...Vitraloy PAN Polyaniline LCE IPMC Ionic Gel Structural metals – dislocations Polymer – reptation Active materials – domains motion Intercalants – free

  16. An integrated QCM-based narcotics sensing microsystem. (United States)

    Frisk, Thomas; Sandström, Niklas; Eng, Lars; van der Wijngaart, Wouter; Månsson, Per; Stemme, Göran


    We present the design, fabrication and successful testing of a 14x14x4 mm3 integrated electronic narcotics sensing system which consists of only four parts. The microsystem absorbs airborne narcotics molecules and performs a liquid assay using an integrated quartz crystal microbalance (QCM). A vertically conductive double-sided adhesive foil (VCAF) was used and studied as a novel material for LOC and MEMS applications and provides easy assembly, electrical contacting and liquid containment. The system was tested for measuring cocaine and ecstasy, with successful detection of amounts as small as 100 ng and 200 ng, respectively. These levels are of interest in security activities in customs, prisons and by the police.

  17. International Forum on Advanced Microsystems for Automotive Application

    CERN Document Server

    Meyer, Gereon


    The automobile is going through the biggest transformation in its history. Automation and electrification of vehicles are expected to enable safer and cleaner mobility. The prospects and requirements of the future automobile affect innovations in major technology fields like driver assistance systems, vehicle networking and drivetrain development. Smart systems such as adaptive ICT components and MEMS devices, novel network architectures, integrated sensor systems, intelligent interfaces and functional materials form the basis of these features and permit their successful and synergetic integration. It has been the mission of the International Forum on Advanced Microsystems for Automotive Applications (AMAA) for more than fifteen years to detect novel trends and to discuss the technological implications from early on. Therefore, the topic of the AMAA 2014 will be “Smart Systems for Safe, Clean, and Automated Vehicles”. This book contains peer-reviewed papers written by leading engineers and researchers w...

  18. Modeling Strategies for Electro-Mechanical Microsystems with Uncertainty Quantification

    NARCIS (Netherlands)

    Hannot, S.D.A.


    Microsystems are very small sensors and actuators, manufactured with the same technology as computer chips. Well known applications of these machines are the acceleration sensors in the Wii game console and the iPhone. At the micrometer length scales of microsystems the physical forces behave diffe

  19. Robust Bioinformatics Recognition with VLSI Biochip Microsystem (United States)

    Lue, Jaw-Chyng L.; Fang, Wai-Chi


    A microsystem architecture for real-time, on-site, robust bioinformatic patterns recognition and analysis has been proposed. This system is compatible with on-chip DNA analysis means such as polymerase chain reaction (PCR)amplification. A corresponding novel artificial neural network (ANN) learning algorithm using new sigmoid-logarithmic transfer function based on error backpropagation (EBP) algorithm is invented. Our results show the trained new ANN can recognize low fluorescence patterns better than the conventional sigmoidal ANN does. A differential logarithmic imaging chip is designed for calculating logarithm of relative intensities of fluorescence signals. The single-rail logarithmic circuit and a prototype ANN chip are designed, fabricated and characterized.

  20. Cost-driven design of smart microsystems

    CERN Document Server

    Niedermayer, Michael


    Today's professionals are constantly striving to create sensor technology and systems with lower cost and higher efficiency. Miniaturization and standardization have become critical drivers for cost reduction in the design and development process, giving rise to a new era of smart sensors and actuators. These devices contain more components, but normally provide significant cost savings due to wider applicability and mass production. This first-of-its-kind resource presents methods for cost optimization of smart microsystems to help you select highly cost-efficient implementation variants. Wri

  1. Microsystem design framework based on tool adaptations and library developments (United States)

    Karam, Jean Michel; Courtois, Bernard; Rencz, Marta; Poppe, Andras; Szekely, Vladimir


    Besides foundry facilities, Computer-Aided Design (CAD) tools are also required to move microsystems from research prototypes to an industrial market. This paper describes a Computer-Aided-Design Framework for microsystems, based on selected existing software packages adapted and extended for microsystem technology, assembled with libraries where models are available in the form of standard cells described at different levels (symbolic, system/behavioral, layout). In microelectronics, CAD has already attained a highly sophisticated and professional level, where complete fabrication sequences are simulated and the device and system operation is completely tested before manufacturing. In comparison, the art of microsystem design and modelling is still in its infancy. However, at least for the numerical simulation of the operation of single microsystem components, such as mechanical resonators, thermo-elements, elastic diaphragms, reliable simulation tools are available. For the different engineering disciplines (like electronics, mechanics, optics, etc) a lot of CAD-tools for the design, simulation and verification of specific devices are available, but there is no CAD-environment within which we could perform a (micro-)system simulation due to the different nature of the devices. In general there are two different approaches to overcome this limitation: the first possibility would be to develop a new framework tailored for microsystem-engineering. The second approach, much more realistic, would be to use the existing CAD-tools which contain the most promising features, and to extend these tools so that they can be used for the simulation and verification of microsystems and of the devices involved. These tools are assembled with libraries in a microsystem design environment allowing a continuous design flow. The approach is driven by the wish to make microsystems accessible to a large community of people, including SMEs and non-specialized academic institutions.

  2. Hyperspectral Polymer Solar Cells, Integrated Power for Microsystems

    Energy Technology Data Exchange (ETDEWEB)

    Stiebitz, Paul [Rochester Institute of Technology, NY (United States)


    The purpose of this research is to address a critical technology barrier to the deployment of next generation autonomous microsystems – the availability of efficient and reliable power sources. The vast majority of research on microsystems has been directed toward the development and miniaturization of sensors and other devices that enhance their intelligence, physical, and networking capabilities. However, the research into power generating and power storage technologies has not keep pace with this development. This research leveraged the capabilities of RIT’s NanoPower Research Laboratories (NPRL) in materials for advanced lithium ion batteries, nanostructured photovoltaics, and hybrid betavoltaics to develop reliable power sources for microsystems.

  3. Micro-system inertial sensing technology overview.

    Energy Technology Data Exchange (ETDEWEB)

    Allen, James Joe


    The purpose of this report is to provide an overview of Micro-System technology as it applies to inertial sensing. Transduction methods are reviewed with capacitance and piezoresistive being the most often used in COTS Micro-electro-mechanical system (MEMS) inertial sensors. Optical transduction is the most recent transduction method having significant impact on improving sensor resolution. A few other methods are motioned which are in a R&D status to hopefully allow MEMS inertial sensors to become viable as a navigation grade sensor. The accelerometer, gyroscope and gravity gradiometer are the type of inertial sensors which are reviewed in this report. Their method of operation and a sampling of COTS sensors and grade are reviewed as well.

  4. Micro-concentrators for a microsystems-enabled photovoltaic system. (United States)

    Jared, Bradley H; Saavedra, Michael P; Anderson, Ben J; Goeke, Ron S; Sweatt, William C; Nielson, Gregory N; Okandan, Murat; Elisberg, Brenton; Snively, Dave; Duncan, John; Gu, Tian; Agrawal, Gautam; Haney, Michael W


    A 100X magnification, ± 2.5° field of view micro-concentrating optical system has been developed for a microsystems-enabled photovoltaic (MEPV) prototype module using 250 µm diameter multi-junction "stacked" PV cells.

  5. Microsystems Engineering of Lab-on-a-Chip Devices

    DEFF Research Database (Denmark)

    , mechanics and fluidics, have to be miniaturized. In this book we will discuss the different aspects of (bio)chemical microsystem development, which are simulation, design, materials, microfabrication, microliquid handling components, interconnections, integration and applications. These topics...

  6. A bioanalytical microsystem for protein and DNA sensing based on a monolithic silicon optoelectronic transducer

    Energy Technology Data Exchange (ETDEWEB)

    Misiakos, K [Microelectronics Institute, NCSR ' Demokritos' , 15310, Athens (Greece); Petrou, P S [Immunoassay Lab., I/R-RP, NCSR ' Demokritos' , 15310, Athens (Greece); Kakabakos, S E [Immunoassay Lab., I/R-RP, NCSR ' Demokritos' , 15310, Athens (Greece); Ruf, H H [Fraunhofer Institute of Biomedical Engineering (IBMT) and University of Saarland, 66386, St Ingbert (Germany); Ehrentreich-Foerster, E [Department of Molecular Bioanalytics and Bioelectronics, Fraunhofer Institute for Biomedical Engineering, D-14558 Nuthetal (Germany); Bier, F F [Department of Molecular Bioanalytics and Bioelectronics, Fraunhofer Institute for Biomedical Engineering, D-14558 Nuthetal (Germany)


    A bioanalytical microsystem that is based on a monolithic silicon optical transducer and a microfluidic module and it is appropriate for real-time sensing of either DNA or protein analytes is presented. The optical transducer monolithically integrates silicon avalanche diodes as light sources, silicon nitride optical fibers and detectors and efficiently intercouples these optical elements through a self-alignment technique. After hydrophilization and silanization of the transducer surface, the biomolecular probes are immobilized through physical adsorption. Detection is performed through reaction of the immobilized biomolecules with gold nanoparticle labeled counterpart molecules. The binding of these molecules within the evanescent field at the surface of the optical fiber cause attenuated total reflection of the waveguided modes and reduction of the detector photocurrent. Using the developed microsystem, determination of single nucleotide polymorphism (SNP) in the gene of the human phenol sulfotransferase SULT1A1 was achieved. Full-matching hybrid resulted in 4-5 times higher signals compared to the mismatched hybrid after hybridization and dissociation processes. The protein sensing abilities of the developed microsystem were also investigated through a non-competitive assay for the determination of the MB isoform of creatine kinase enzyme (CK-MB) that is a widely used cardiac marker.

  7. Amperometric electrochemical microsystem for a miniaturized protein biosensor array. (United States)

    Chao Yang; Yue Huang; Hassler, B L; Worden, R M; Mason, A J


    Protein-based bioelectrochemical interfaces offer great potential for rapid detection, continuous use, and miniaturized sensor arrays. This paper introduces a microsystem platform that enables multiple bioelectrochemical interfaces to be interrogated simultaneously by an onchip amperometric readout system. A post-complementary metal-oxide semiconductor (CMOS) fabrication procedure is described that permits the formation of planar electrode arrays and self assembly of biosensor interfaces on the electrodes. The onchip, 0.5-mum CMOS readout electronics include a compact potentiostat that supports a very broad range of input currents-6 pA to 10 muA-to accommodate diverse biosensor interfaces. The 2.3 times 2.2-mm chip operates from a 5-V supply at 0.6 mA. A prototype electrochemical sensor platform, including an onchip potentiostat and miniaturized biosensor array, was characterized by using cyclic voltammetry. The linear relationship between the oxidization peak values and the concentrations of target analytes in the solution verifies functionality of the system and demonstrates the potential for future implementations of this platform in high sensitivity, low cost, and onchip protein-based sensor arrays.

  8. Analytical heat and fluid flow in microchannels and microsystems

    CERN Document Server

    Cotta, Renato M; Naveira-Cotta, Carolina P


    This book focuses on the modeling and analysis of heat and fluid flow in microchannels and micro-systems, compiling a number of analytical and hybrid numerical-analytical solutions for models that account for the relevant micro-scale effects, with the corresponding experimental analysis validation when applicable. The volume stands as the only available compilation of easy to use analytically-based solutions for micro-scale heat and fluid flow problems, that systematically incorporates the most relevant micro-scale effects into the mathematical models, followed by their physical interpretation on the micro-system behavior.

  9. Introduction to microsystem technology a guide for students

    CERN Document Server

    Gerlach, Gerald; Müller, Dörte


    Over half a century after the discovery of the piezoresistive effect, microsystem technology has experienced considerable developments. Expanding the opportunities of microelectronics to non-electronic systems, its number of application fields continues to increase. Microsensors are one of the most important fields, used in medical applications and micromechanics. Microfluidic systems are also a significant area, most commonly used in ink-jet printer heads. This textbook focuses on the essentials of microsystems technology, providing a knowledgeable grounding and a clear path through this we

  10. Microsystem engineering of lab-on-a-chip devices

    CERN Document Server

    Geschke, Oliver; Telleman, Pieter


    Written on a non-specialist level by an interdisciplinary team of chemists, biologists and engineers from one of Europe's leading centres for microsystem research, the Danish Mikroelektronik Centret (MIC), this is a concise practical introduction to the subject. As such, the book is the first to focus on analytical applications, providing life and analytical scientists, biotechnologists and pharmaceutists with an understanding of the principles behind the design and manufacture of chemical and biochemical microsystems. The text is backed by a chapter devoted to troubleshooting as well as a g

  11. Preliminary Thermal Characterization of a Fully-Passive Wireless Backscattering Neuro-Recording Microsystem (United States)

    Schwerdt, H. N.; Xu, W.; Shekhar, S.; Chae, J.; Miranda, F. A.


    We present analytical and experimental thermal characteristics of a battery-less, fully-passive wireless backscattering microsystem for recording of neuropotentials. A major challenge for cortically implantable microsystems involves minimizing the heat dissipated by on-chip circuitry, which can lead to permanent brain damage. Therefore, knowledge of temperature changes induced by implantable microsystems while in operation is of utmost importance. In this work, a discrete diode appended to the neuro-recording microsystem has been used to indirectly monitor the aforesaid temperature changes. Using this technique, the maximum temperature rise measured for the microsystem while in operation was 0.15 +/- 0.1 C, which is significantly less than current safety guidelines. Specific absorption ratio (SAR) due to the microsystem was also computed to further demonstrate fully-passive functionality of the neuro-recording microsystem.

  12. Internet Use and Child Development: The Techno-Microsystem (United States)

    Johnson, Genevieve Marie


    Ecological systems theory assumes that child development is the consequence of ongoing reciprocal and spiraling interactions between the child and his/her microsystem (immediate home, school, and community environments). The increasing presence of digital technologies in children's immediate environments suggests the need for the proposed…

  13. Macro-meso-microsystems integration in LTCC : LDRD report.

    Energy Technology Data Exchange (ETDEWEB)

    De Smet, Dennis J.; Nordquist, Christopher Daniel; Turner, Timothy Shawn; Rohrer, Brandon Robinson; Walker, Charles A.; Ho, Clifford K..; Patel, Kamlesh D.; Okandan, Murat; Rohde, Steven Barney; Wroblewski, Brian D.; Pfeifer, Kent Bryant; Peterson, Kenneth Allen; Buerger, Stephen P.


    Low Temperature Cofired Ceramic (LTCC) has proven to be an enabling medium for microsystem technologies, because of its desirable electrical, physical, and chemical properties coupled with its capability for rapid prototyping and scalable manufacturing of components. LTCC is viewed as an extension of hybrid microcircuits, and in that function it enables development, testing, and deployment of silicon microsystems. However, its versatility has allowed it to succeed as a microsystem medium in its own right, with applications in non-microelectronic meso-scale devices and in a range of sensor devices. Applications include silicon microfluidic ''chip-and-wire'' systems and fluid grid array (FGA)/microfluidic multichip modules using embedded channels in LTCC, and cofired electro-mechanical systems with moving parts. Both the microfluidic and mechanical system applications are enabled by sacrificial volume materials (SVM), which serve to create and maintain cavities and separation gaps during the lamination and cofiring process. SVMs consisting of thermally fugitive or partially inert materials are easily incorporated. Recognizing the premium on devices that are cofired rather than assembled, we report on functional-as-released and functional-as-fired moving parts. Additional applications for cofired transparent windows, some as small as an optical fiber, are also described. The applications described help pave the way for widespread application of LTCC to biomedical, control, analysis, characterization, and radio frequency (RF) functions for macro-meso-microsystems.

  14. A Differential Monolithically Integrated Inductive Linear Displacement Measurement Microsystem

    Directory of Open Access Journals (Sweden)

    Matija Podhraški


    Full Text Available An inductive linear displacement measurement microsystem realized as a monolithic Application-Specific Integrated Circuit (ASIC is presented. The system comprises integrated microtransformers as sensing elements, and analog front-end electronics for signal processing and demodulation, both jointly fabricated in a conventional commercially available four-metal 350-nm CMOS process. The key novelty of the presented system is its full integration, straightforward fabrication, and ease of application, requiring no external light or magnetic field source. Such systems therefore have the possibility of substituting certain conventional position encoder types. The microtransformers are excited by an AC signal in MHz range. The displacement information is modulated into the AC signal by a metal grating scale placed over the microsystem, employing a differential measurement principle. Homodyne mixing is used for the demodulation of the scale displacement information, returned by the ASIC as a DC signal in two quadrature channels allowing the determination of linear position of the target scale. The microsystem design, simulations, and characterization are presented. Various system operating conditions such as frequency, phase, target scale material and distance have been experimentally evaluated. The best results have been achieved at 4 MHz, demonstrating a linear resolution of 20 µm with steel and copper scale, having respective sensitivities of 0.71 V/mm and 0.99 V/mm.

  15. A Differential Monolithically Integrated Inductive Linear Displacement Measurement Microsystem (United States)

    Podhraški, Matija; Trontelj, Janez


    An inductive linear displacement measurement microsystem realized as a monolithic Application-Specific Integrated Circuit (ASIC) is presented. The system comprises integrated microtransformers as sensing elements, and analog front-end electronics for signal processing and demodulation, both jointly fabricated in a conventional commercially available four-metal 350-nm CMOS process. The key novelty of the presented system is its full integration, straightforward fabrication, and ease of application, requiring no external light or magnetic field source. Such systems therefore have the possibility of substituting certain conventional position encoder types. The microtransformers are excited by an AC signal in MHz range. The displacement information is modulated into the AC signal by a metal grating scale placed over the microsystem, employing a differential measurement principle. Homodyne mixing is used for the demodulation of the scale displacement information, returned by the ASIC as a DC signal in two quadrature channels allowing the determination of linear position of the target scale. The microsystem design, simulations, and characterization are presented. Various system operating conditions such as frequency, phase, target scale material and distance have been experimentally evaluated. The best results have been achieved at 4 MHz, demonstrating a linear resolution of 20 µm with steel and copper scale, having respective sensitivities of 0.71 V/mm and 0.99 V/mm. PMID:26999146

  16. A Differential Monolithically Integrated Inductive Linear Displacement Measurement Microsystem. (United States)

    Podhraški, Matija; Trontelj, Janez


    An inductive linear displacement measurement microsystem realized as a monolithic Application-Specific Integrated Circuit (ASIC) is presented. The system comprises integrated microtransformers as sensing elements, and analog front-end electronics for signal processing and demodulation, both jointly fabricated in a conventional commercially available four-metal 350-nm CMOS process. The key novelty of the presented system is its full integration, straightforward fabrication, and ease of application, requiring no external light or magnetic field source. Such systems therefore have the possibility of substituting certain conventional position encoder types. The microtransformers are excited by an AC signal in MHz range. The displacement information is modulated into the AC signal by a metal grating scale placed over the microsystem, employing a differential measurement principle. Homodyne mixing is used for the demodulation of the scale displacement information, returned by the ASIC as a DC signal in two quadrature channels allowing the determination of linear position of the target scale. The microsystem design, simulations, and characterization are presented. Various system operating conditions such as frequency, phase, target scale material and distance have been experimentally evaluated. The best results have been achieved at 4 MHz, demonstrating a linear resolution of 20 µm with steel and copper scale, having respective sensitivities of 0.71 V/mm and 0.99 V/mm.

  17. 17th National Conference on Sensors and Microsystems

    CERN Document Server

    Ferrari, Vittorio; Ponzoni, Andrea; Sberveglieri, Giorgio; Ferrari, Marco


    This book contains a selection of papers presented at the 17th AISEM (“Associazione Italiana Sensori e Microsistemi”) National Conference on Sensors and Microsystems, held in Brescia, 5-7 February, 2013. The conference highlighted state-of-the-art results from both theoretical and applied research in the field of sensors and related technologies. This book presents material in an interdisciplinary approach, covering many aspects of the disciplines related to sensors, including physics, chemistry, materials science, biology and applications.  ·         Provides a selection of the best papers from the 17th National Conference on Sensors and Microsystems; ·         Covers a broad range of topics relating to sensors and microsystems, including physics, chemistry, materials science, biology and applications; ·         Offers interdisciplinary coverage, aimed at defining a common ground for sensors beyond the specific differences among the different particular implementation of senso...

  18. Detection of Dissolved Lactose Employing an Optofluidic Micro-System

    Directory of Open Access Journals (Sweden)

    Franz Keplinger


    Full Text Available In this work, a novel optofluidic sensor principle is employed for a non-invasive and label-free characterization of lactose containing liquid samples. Especially for medicine and food industry, a simple, fast and accurate determination of the amount of lactose in various products is highly desirable. The presented system exploits the impact of dissolved molecules on the refractive index for sample characterization. On the optofluidic chip, a microfluidic channel filled with the analyte is hit by slightly diverging laser light. The center incident angle of the beam on-chip is set close to the critical angle for total internal reflection. Both the reflected and the transmitted light signals are recorded at the solid-liquid interface. The ratio of those two signals is then used as representative value for the analyte. Using this principle, lactose containing samples were differentiated based on their concentrations at a step size of 10 mmol/L. The use of the signals ratio instead of a single signal approach improves the stability of the system significantly, allowing for higher resolutions to be achieved. Furthermore, the fabrication of the devices in PDMS ensures biocompatibility and provides low absorbance of light in the visible range.

  19. 16th International Forum on Advanced Microsystems for Automotive Applications (AMAA)

    CERN Document Server

    Advanced Microsystems for Automotive Applications 2012 : Smart Systems for Safe, Sustainable and Networked Vehicles


    The ambitious objectives of future road mobility, i.e. fuel efficiency, reduced emissions, and zero accidents, imply a paradigm shift in the concept of the car regarding its architecture, materials, and propulsion technology, and require an intelligent integration into the systems of transportation and power. ICT, components and smart systems have been essential for a multitude of recent innovations, and are expected to be key enabling technologies for the changes ahead, both inside the vehicle and at its interfaces for the exchange of data and power with the outside world. It has been the objective of the International Forum on Advanced Microsystems for Automotive Applications (AMAA) for almost two decades to detect novel trends and to discuss technological implications and innovation potential from day one on. In 2012, the topic of the AMAA conference is “Smart Systems for Safe, Sustainable and Networked Vehicles”. The conference papers selected for this book address current research, developments and i...

  20. Advanced microsystems for automotive applications 2013 smart systems for safe and green vehicles

    CERN Document Server

    Meyer, Gereon


    The road vehicle of the future will embrace innovations from three major automotive technology fields: driver assistance systems, vehicle networking and alternative propulsion. Smart systems such as adaptive ICT components and MEMS devices, novel network architectures, integrated sensor systems, intelligent interfaces and functional materials form the basis of these features and permit their successful and synergetic integration. They increasingly appear to be the key enabling technologies for safe and green road mobility. For more than fifteen years the International Forum on Advanced Microsystems for Automotive Applications (AMAA) has been successful in detecting novel trends and in discussing the technological implications from early on. The topic of the AMAA 2013 will be “Smart Systems for Safe and Green Vehicles”. This book contains peer-reviewed papers written by leading engineers and researchers which all address the ongoing research and novel developments in the field.

  1. VLSI Microsystem for Rapid Bioinformatic Pattern Recognition (United States)

    Fang, Wai-Chi; Lue, Jaw-Chyng


    A system comprising very-large-scale integrated (VLSI) circuits is being developed as a means of bioinformatics-oriented analysis and recognition of patterns of fluorescence generated in a microarray in an advanced, highly miniaturized, portable genetic-expression-assay instrument. Such an instrument implements an on-chip combination of polymerase chain reactions and electrochemical transduction for amplification and detection of deoxyribonucleic acid (DNA).

  2. MBB strategy consideration: From microsystem technique to the space transportation system SAENGER 2 (United States)

    Vogels, Hanns Arnt

    Microsystems technique, as an example of technology developments, and the future space transportation system SAENGER 2 are treated. Microelectronics, micromechanics, and microoptics are presented. The characteristics of the materials used in microsystems technology are discussed. Economic and nonpolluting solar energy systems for future space systems are discussed. The status and the future of hypersonic transportation systems are discussed.

  3. An analysis of microsystems development at Sandia National Laboratories (United States)

    Herrera, Gilbert V.; Myers, David R.


    While Sandia initially was motivated to investigate emergent microsystem technology to miniaturize existing macroscale structures, present designs embody innovative approaches that directly exploit the fundamentally different material properties of a new technology at the micro- and nano-scale. Direct, hands-on experience with the emerging technology gave Sandia engineers insights that not only guided the evolution of the technology but also enabled them to address new applications that enlarged the customer base for the new technology. Sandia's early commitment to develop complex microsystems demonstrated the advantages that early adopters gain by developing an extensive design and process tool kit and a shared awareness of multiple approaches to achieve the multiple goals. As with any emergent technology, Sandia's program benefited from interactions with the larger technical community. However, custom development followed a spiral path of direct trial-and-error experience, analysis, quantification of materials properties at the micro- and nano-scale, evolution of design tools and process recipes, and an understanding of reliability factors and failure mechanisms even in extreme environments. The microsystems capability at Sandia relied on three key elements. The first was people: a mix of mechanical and semiconductor engineers, chemists, physical scientists, designers, and numerical analysts. The second was a unique facility that enabled the development of custom technologies without contaminating mainline product deliveries. The third was the arrival of specialized equipment as part of a Cooperative Research And Development Agreement (CRADA) enabled by the National Competitiveness Technology Transfer Act of 1989. Underpinning all these, the program was guided and sustained through the research and development phases by accomplishing intermediate milestones addressing direct mission needs.

  4. Microsystems for enhanced control of cell behavior fundamentals, design and manufacturing strategies, applications and challenges

    CERN Document Server


    This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (incl...

  5. Development of vapor deposited thin films for bio-microsystems (United States)

    Popat, Ketul Chandrakant

    Increasing demands for more biocompatible and sophisticated bio-microsystems in recent years has led to the development of a new technology called BioMEMS (biological micro-electro-mechanical systems). The foundation of this technology is the same as that of the traditional field of IC (integrated circuits), but an emphasis on developing new diagnostic and therapeutic modalities. Micro- and nano-fabrication techniques are currently being used to develop implants that can record, sense, stimulate and deliver to biological systems. Micromachined substrates can provide unique advantages over traditional implantable devices in terms of their ability to control surface micro-architecture, topography and feature size in micron and nano sizes. However, as BioMEMS technology is rapidly being developed, the practical use of these bio-microsystems is limited due to the inability to effectively interface with the biological system in non-immunogenic and stable manner. This is one of the most important considerations, and hence it is useful to focus on the fundamental scientific issues relating to material science, surface chemistry and immunology of silicon based bio-microsystems. This results in development of biomolecular interfaces that are compatible with both microfabrication processing and biological systems. The overall thrust of this research is to develop, characterize and integrate vapor deposited thin films with bio-microsystems in a manner that it is both reproducible and fully integrated with existing technologies. The main strategy is to use silane coatings precursor coatings on which poly (ethylene glycol) (PEG) will be coated in vapor phase. Silane has been coated user vapor phase, but its chemical and biological characterization and stability of the films under physiological conditions has not been investigated for biological applications. PEG has been coated in solution phase on silicon surface. However, it has not been coated under vapor phase. Here we are

  6. Separation and sorting of cells in microsystems using physical principles (United States)

    Lee, Gi-Hun; Kim, Sung-Hwan; Ahn, Kihoon; Lee, Sang-Hoon; Park, Joong Yull


    In the last decade, microfabrication techniques have been combined with microfluidics and applied to cell biology. Utilizing such new techniques, various cell studies have been performed for the research of stem cells, immune cells, cancer, neurons, etc. Among the various biological applications of microtechnology-based platforms, cell separation technology has been highly regarded in biological and clinical fields for sorting different types of cells, finding circulating tumor cells (CTCs), and blood cell separation, amongst other things. Many cell separation methods have been created using various physical principles. Representatively, these include hydrodynamic, acoustic, dielectrophoretic, magnetic, optical, and filtering methods. In this review, each of these methods will be introduced, and their physical principles and sample applications described. Each physical principle has its own advantages and disadvantages. The engineers who design the systems and the biologists who use them should understand the pros and cons of each method or principle, to broaden the use of microsystems for cell separation. Continuous development of microsystems for cell separation will lead to new opportunities for diagnosing CTCs and cancer metastasis, as well as other elements in the bloodstream.

  7. Chalk-microfluidic: flooding microsystems with reactive fluids (United States)

    Neuville, Amélie; Dysthe, Dag Kristian; Li, Lei; Hiorth, Aksel


    Experiments on core scale and field tests that have been carried out the last decade have clearly shown that water chemistry affects the final oil recovery. However, there is generally no consensus in the scientific community of why additional oil is released. Part of the reason for this is that there are very few in-situ observations of how the water chemistry affects fluid distributions on the pore scale, and/or the pore surface characteristics. In this work, as a first step, our aim is to focus on in-situ observations of single phase flow and interactions at the pore scale. In order to work at this small scale, we first investigate how to control the flow location. We propose to use the same principle as "paper-microfluidic": some areas of the chalk are chemically treated so that no fluid flows inside while other areas let the fluids flow in the chalk pores. Since chalk and paper obviously has different mechanical behavior, we need to adapt this technique. Custom-made microsystems with chalk and calcite will be presented. We will then show experiments with reacting fluids in these microsystems. These experiments are observed using wide field fluorescence microscopy and white light vertical/phase shift interferometric microscopy.

  8. CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review. (United States)

    Li, Haitao; Liu, Xiaowen; Li, Lin; Mu, Xiaoyi; Genov, Roman; Mason, Andrew J


    Modern biosensors play a critical role in healthcare and have a quickly growing commercial market. Compared to traditional optical-based sensing, electrochemical biosensors are attractive due to superior performance in response time, cost, complexity and potential for miniaturization. To address the shortcomings of traditional benchtop electrochemical instruments, in recent years, many complementary metal oxide semiconductor (CMOS) instrumentation circuits have been reported for electrochemical biosensors. This paper provides a review and analysis of CMOS electrochemical instrumentation circuits. First, important concepts in electrochemical sensing are presented from an instrumentation point of view. Then, electrochemical instrumentation circuits are organized into functional classes, and reported CMOS circuits are reviewed and analyzed to illuminate design options and performance tradeoffs. Finally, recent trends and challenges toward on-CMOS sensor integration that could enable highly miniaturized electrochemical biosensor microsystems are discussed. The information in the paper can guide next generation electrochemical sensor design.

  9. Microsystems for pharmatechnology manipulation of fluids, particles, droplets, and cells

    CERN Document Server


    This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.

  10. CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review (United States)

    Li, Haitao; Liu, Xiaowen; Li, Lin; Mu, Xiaoyi; Genov, Roman; Mason, Andrew J.


    Modern biosensors play a critical role in healthcare and have a quickly growing commercial market. Compared to traditional optical-based sensing, electrochemical biosensors are attractive due to superior performance in response time, cost, complexity and potential for miniaturization. To address the shortcomings of traditional benchtop electrochemical instruments, in recent years, many complementary metal oxide semiconductor (CMOS) instrumentation circuits have been reported for electrochemical biosensors. This paper provides a review and analysis of CMOS electrochemical instrumentation circuits. First, important concepts in electrochemical sensing are presented from an instrumentation point of view. Then, electrochemical instrumentation circuits are organized into functional classes, and reported CMOS circuits are reviewed and analyzed to illuminate design options and performance tradeoffs. Finally, recent trends and challenges toward on-CMOS sensor integration that could enable highly miniaturized electrochemical biosensor microsystems are discussed. The information in the paper can guide next generation electrochemical sensor design. PMID:28042860

  11. From microsystems technology to the Saenger II space transportation system (United States)

    Vogels, Hanns Arnt

    The role of space projects as drivers and catalysts of technology advances is discussed and illustrated from the perspective of the West German aerospace industry, summarizing a talk presented at the 1986 meeting of the German aerospace society DGLR. The history of space-transportation-system (STS) technology since the 1950s is traced, emphasizing the needs for greater payload weights and lower costs, and the design concept of Saenger II, a proposed two-stage ESA STS employing a hypersonic jet transport aircraft as its first stage, is outlined. It is argued that experience gained in developing the rocket-launched Hermes STS will be applicable to the second stage of Saenger II. Recent developments in microsystems (combining microelectronics, micromechanics, and microoptics), advanced materials (fiber-reinforced plastics, metals, and ceramics), and energy technology (hydrogen-based systems and solar cells) are surveyed, and their applicability to STSs is considered.

  12. Micro-system Design for Wireless Endoscopy System. (United States)

    Xie, Xiang; Li, Guolin; Chi, Baoyong; Yu, Xueyi; Zhang, Chun; Wang, Zhihua


    This paper proposes a micro-system design for the wireless endoscopic capsule, which assures that the capsule has small size(less than 25mm*10mm), can implement the diagnoses of whole human digestive tract and provide real time endoscopic image monitoring. The designs of two core hardware parts inside the capsule, low power analog-digital mix-mode single-chip and micro-antenna are discussed in detail. A new automatic retransmission request (ARQ) communication scheme is proposed for the high quality image communication system. The micro-antenna design with less than 9 mm diameter is implemented. The digital circuits have been verified on FPGAs and analog circuits have been simulated. The analog-digital mix-mode single-chip has been implemented in 0.18μm CMOS process.

  13. Shape-dependent orientation of thermophoretic forces in microsystems

    KAUST Repository

    Li, Qi


    It is generally acknowledged that the direction of the thermophoretic force acting on microparticles is largely determined by the imposed temperature gradient, and the shape of the microparticle has little influence on its direction. We show that one type of thermophoretic force, emerged due to the advent of microfabrication techniques, is highly sensitive to object shape, and it is feasible to tune force orientation via proper shape design. We reveal the underlying mechanism by an asymptotic analysis of the Boltzmann equation and point out the reason why the classical thermophoretic force is insensitive to the particle shape, but the force in microsystems is. The discovered phenomenon could find its applications in methods for microparticle manipulation and separation.

  14. CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

    Directory of Open Access Journals (Sweden)

    Haitao Li


    Full Text Available Modern biosensors play a critical role in healthcare and have a quickly growing commercial market. Compared to traditional optical-based sensing, electrochemical biosensors are attractive due to superior performance in response time, cost, complexity and potential for miniaturization. To address the shortcomings of traditional benchtop electrochemical instruments, in recent years, many complementary metal oxide semiconductor (CMOS instrumentation circuits have been reported for electrochemical biosensors. This paper provides a review and analysis of CMOS electrochemical instrumentation circuits. First, important concepts in electrochemical sensing are presented from an instrumentation point of view. Then, electrochemical instrumentation circuits are organized into functional classes, and reported CMOS circuits are reviewed and analyzed to illuminate design options and performance tradeoffs. Finally, recent trends and challenges toward on-CMOS sensor integration that could enable highly miniaturized electrochemical biosensor microsystems are discussed. The information in the paper can guide next generation electrochemical sensor design.

  15. In-plane biocompatible microfluidic interconnects for implantable microsystems. (United States)

    Johnson, Dean G; Frisina, Robert D; Borkholder, David A


    Small mammals, particularly mice, are very useful animal models for biomedical research. Extremely small anatomical dimensions, however, make design of implantable microsystems quite challenging. A method for coupling external fluidic systems to microfluidic channels via in-plane interconnects is presented. Capillary tubing is inserted into channels etched in the surface of a Si wafer with a seal created by Parylene-C deposition. Prediction of Parylene-C deposition into tapered channels based on Knudsen diffusion and deposition characterizations allows for design optimization. Low-volume interconnects using biocompatible, chemical resistant materials have been demonstrated and shown to withstand pressure as high as 827 kPa (120 psi) with an average pull test strength of 2.9 N. Each interconnect consumes less than 0.018 mm3 (18 nL) of volume. The low added volume makes this an ideal interconnect technology for medical applications where implant volume is critical.

  16. Biparametric potentiometric analytical microsystem for nitrate and potassium monitoring in water recycling processes for manned space missions. (United States)

    Calvo-López, Antonio; Arasa-Puig, Eva; Puyol, Mar; Casalta, Joan Manel; Alonso-Chamarro, Julián


    The construction and evaluation of a Low Temperature Co-fired Ceramics (LTCC)-based continuous flow potentiometric microanalyzer prototype to simultaneously monitor the presence of two ions (potassium and nitrate) in samples from the water recycling process for future manned space missions is presented. The microsystem integrates microfluidics and the detection system in a single substrate and it is smaller than a credit card. The detection system is based on two ion-selective electrodes (ISEs), which are built using all-solid state nitrate and potassium polymeric membranes, and a screen-printed Ag/AgCl reference electrode. The obtained analytical features after the optimization of the microfluidic design and hydrodynamics are a linear range from 10 to 1000 mg L(-1) and from 1.9 to 155 mg L(-1) and a detection limit of 9.56 mg L(-1) and 0.81 mg L(-1) for nitrate and potassium ions respectively.

  17. Wireless Performance of a Fully Passive Neurorecording Microsystem Embedded in Dispersive Human Head Phantom (United States)

    Schwerdt, Helen N.; Chae, Junseok; Miranda, Felix A.


    This paper reports the wireless performance of a biocompatible fully passive microsystem implanted in phantom media simulating the dispersive dielectric properties of the human head, for potential application in recording cortical neuropotentials. Fully passive wireless operation is achieved by means of backscattering electromagnetic (EM) waves carrying 3rd order harmonic mixing products (2f(sub 0) plus or minus f(sub m)=4.4-4.9 GHZ) containing targeted neuropotential signals (fm approximately equal to 1-1000 Hz). The microsystem is enclosed in 4 micrometer thick parylene-C for biocompatibility and has a footprint of 4 millimeters x 12 millimeters x 500 micrometers. Preliminary testing of the microsystem implanted in the lossy biological simulating media results in signal-to-noise ratio's (SNR) near 22 (SNR approximately equal to 38 in free space) for millivolt level neuropotentials, demonstrating the potential for fully passive wireless microsystems in implantable medical applications.

  18. Integrating nanotubes into microsystems with electron beam lithography and in situ catalytically activated growth

    DEFF Research Database (Denmark)

    Gjerde, Kjetil; Fornés-Mora, Marc; Kjelstrup-Hansen, Jakob;


    Integration of freestanding wire-like structures such as multi walled carbon nanotubes (MWCNT) into microsystems has many potential applications. Devices such as AFM tips or improved electrodes for conductivity measurements are obvious candidates. Catalytically activated growth opens up...... the possibility of waferscale fabrication of such devices. We combine conventional microfabrication techniques with state of the art electron beam lithography (EBL) to precisely position catalyst nanoparticles with sub 100 nm diameter into the microsystems. In particular, we have explored two main approaches...

  19. Microsystems technologist workforce development capacity and challenges in Central New Mexico.

    Energy Technology Data Exchange (ETDEWEB)

    Osborn, Thor D.


    Sandia National Laboratories has made major investments in microsystems-related infrastructure and research staff development over the past two decades, culminating most recently in the MESA project. These investment decisions have been made based in part upon the necessity for highly reliable, secure, and for some purposes, radiation-hardened devices and subsystems for safety and sustainability of the United States nuclear arsenal and other national security applications. SNL's microsystems development and fabrication capabilities are located almost entirely within its New Mexico site, rendering their effectiveness somewhat dependent on the depth and breadth of the local microsystems workforce. Consequently, the status and development capacity of this workforce has been seen as a key personnel readiness issue in relation to the maintenance of SNL's microsystems capabilities. For this reason SNL has supported the instantiation and development of the Southwest Center for Microsystems Education, an Advanced Technology Education center funded primarily by the National Science Foundation, in order to foster the development of local training capacity for microsystems technologists. Although the SCME and the associated Manufacturing Technology program at Central New Mexico Community College have developed an effective curriculum and graduated several highly capable microsystems technologists, the future of both the center and the degree program remain uncertain due to insufficient student enrollment. The central region of New Mexico has become home to many microsystems-oriented commercial firms. As the demands of those firms for technologists evolve, SNL may face staffing problems in the future, especially if local training capacity is lost.

  20. Biomimetic/Bioinspired Design of Enzyme@capsule Nano/Microsystems. (United States)

    Shi, J; Jiang, Y; Zhang, S; Yang, D; Jiang, Z


    Enzyme@capsule nano/microsystems, which refer to the enzyme-immobilized capsules, have received tremendous interest owing to the combination of the high catalytic activities of encapsulated enzymes and the hierarchical structure of the capsule. The preparation of capsules and simultaneous encapsulation of enzymes is recognized as the core process for the rational design and construction of enzyme@capsule nano/microsystems. The strategy used has three major steps: (a) generation of the templates, (b) surface coating on the templates, and (c) removal of the templates, and it has been proven to be effective and versatile for the construction of enzyme@capsule nano/microsystems. Several conventional methods, including layer-by-layer assembly of polyelectrolytes, liquid crystalline templating method, etc., were used to design and construct enzyme@capsule nano/microsystems, but these have two major drawbacks. One is the low mechanical stability of the systems and the second is the harsh conditions used in the construction process. Learning from nature, several biomimetic/bioinspired methods such as biomineralization, biomimetic/bioinspired adhesion, and their combination have been exploited for the construction of enzyme@capsule nano/microsystems. In this chapter, we will present a general protocol for the construction of enzyme@capsule nano/microsystems using the latter approach. Some suggestions for improved design, construction, and characterization will also be presented with detailed procedures for specific examples.

  1. Raman spectroscopic differentiation of beef and horse meat using a 671 nm microsystem diode laser (United States)

    Ebrahim, Halah Al; Sowoidnich, Kay; Kronfeldt, Heinz-Detlef


    A non-invasive Raman spectroscopic approach for meat species identification and quality detection was successfully demonstrated for the two closely related species beef and horse. Fresh beef and horse muscles were cut and ice-stored at 5 °C, and time-dependent Raman measurements were performed daily up to 12 days postmortem. Applying a 671 nm microsystem diode laser and a laser power of 50 mW, spectra were recorded with integration times of 1-4 s. A pronounced offset of the Raman spectra was observed between horse and beef, with high fluorescence background for horse compared to beef for all days of storage. Principal components analysis was applied for data evaluation revealing a clear distinction between beef and horse meat which can be attributed to differences in the myoglobin content of both species. Furthermore, separations according to aging and spoilage for the two species could be identified simultaneously. Therefore, Raman spectroscopy might be an efficient test method for meat species identification in combination with spoilage detection.

  2. FERMI: a digital Front End and Readout MIcrosystem for high resolution calorimetry (United States)

    Alexanian, H.; Appelquist, G.; Bailly, P.; Benetta, R.; Berglund, S.; Bezamat, J.; Blouzon, F.; Bohm, C.; Breveglieri, L.; Brigati, S.; Cattaneo, P. W.; Dadda, L.; David, J.; Engström, M.; Genat, J. F.; Givoletti, M.; Goggi, V. G.; Gong, S.; Grieco, G. M.; Hansen, M.; Hentzell, H.; Holmberg, T.; Höglund, I.; Inkinen, S. J.; Kerek, A.; Landi, C.; Ledortz, O.; Lippi, M.; Lofstedt, B.; Lund-Jensen, B.; Maloberti, F.; Mutz, S.; Nayman, P.; Piuri, V.; Polesello, G.; Sami, M.; Savoy-Navarro, A.; Schwemling, P.; Stefanelli, R.; Sundblad, R.; Svensson, C.; Torelli, G.; Vanuxem, J. P.; Yamdagni, N.; Yuan, J.; Ödmark, A.; Fermi Collaboration


    We present a digital solution for the front-end electronics of high resolution calorimeters at future colliders. It is based on analogue signal compression, high speed {A}/{D} converters, a fully programmable pipeline and a digital signal processing (DSP) chain with local intelligence and system supervision. This digital solution is aimed at providing maximal front-end processing power by performing waveform analysis using DSP methods. For the system integration of the multichannel device a multi-chip, silicon-on-silicon multi-chip module (MCM) has been adopted. This solution allows a high level of integration of complex analogue and digital functions, with excellent flexibility in mixing technologies for the different functional blocks. This type of multichip integration provides a high degree of reliability and programmability at both the function and the system level, with the additional possibility of customising the microsystem to detector-specific requirements. For enhanced reliability in high radiation environments, fault tolerance strategies, i.e. redundancy, reconfigurability, majority voting and coding for error detection and correction, are integrated into the design.

  3. Microsystem for remote sensing of high energy radiation with associated extremely low photon flux densities (United States)

    Otten, A.; Jain, V. K.


    This paper presents a microsystem for remote sensing of high energy radiation in extremely low flux density conditions. With wide deployment in mind, potential applications range from nuclear non-proliferation, to hospital radiation-safety. The daunting challenge is the low level of photon flux densities - emerging from a Scintillation Crystal (SC) on to a ~1 mm-square detector, which are a factor of 10000 or so lower than those acceptable to recently reported photonic chips (including `single-photon detection' chips), due to a combination of low Lux, small detector size, and short duration SC output pulses - on the order of 1 μs. These challenges are attempted to be overcome by the design of an innovative `System on a Chip' type microchip, with high detector sensitivity, and effective coupling from the SC to the photodetector. The microchip houses a tiny n+ diff p-epi photodiode (PD) as well as the associated analog amplification and other related circuitry, all fabricated in 0.5micron, 3-metal 2-poly CMOS technology. The amplification, together with pulse-shaping of the photocurrent-induced voltage signal, is achieved through a tandem of two capacitively coupled, double-cascode amplifiers. Included in the paper are theoretical estimates and experimental results.

  4. Metal oxide-based monolithic complementary metal oxide semiconductor gas sensor microsystem. (United States)

    Graf, Markus; Barrettino, Diego; Taschini, Stefano; Hagleitner, Christoph; Hierlemann, Andreas; Baltes, Henry


    A fully integrated gas sensor microsystem is presented, which comprises for the first time a micro hot plate as well as advanced analog and digital circuitry on a single chip. The micro hot plate is coated with a nanocrystalline SnO2 thick film. The sensor chip is produced in an industrial 0.8-microm CMOS process with subsequent micromachining steps. A novel circular micro hot plate, which is 500 x 500 microm(2) in size, features an excellent temperature homogeneity of +/-2% over the heated area (300-microm diameter) and a high thermal efficiency of 6.0 degrees C/mW. A robust prototype package was developed, which relies on standard microelectronic packaging methods. Apart from a microcontroller board for managing chip communication and providing power supply and reference signals, no additional measurement equipment is needed. The on-chip digital temperature controller can accurately adjust the membrane temperature between 170 and 300 degrees C with an error of +/-2 degrees C. The on-chip logarithmic converter covers a wide measurement range between 1 kOmega and 10 MOmega. CO concentrations in the sub-parts-per-million range are detectable, and a resolution of +/-0.1 ppm CO was achieved, which renders the sensor capable of measuring CO concentrations at threshold levels.

  5. Bio-hybrid cell-based actuators for microsystems. (United States)

    Carlsen, Rika Wright; Sitti, Metin


    As we move towards the miniaturization of devices to perform tasks at the nano and microscale, it has become increasingly important to develop new methods for actuation, sensing, and control. Over the past decade, bio-hybrid methods have been investigated as a promising new approach to overcome the challenges of scaling down robotic and other functional devices. These methods integrate biological cells with artificial components and therefore, can take advantage of the intrinsic actuation and sensing functionalities of biological cells. Here, the recent advancements in bio-hybrid actuation are reviewed, and the challenges associated with the design, fabrication, and control of bio-hybrid microsystems are discussed. As a case study, focus is put on the development of bacteria-driven microswimmers, which has been investigated as a targeted drug delivery carrier. Finally, a future outlook for the development of these systems is provided. The continued integration of biological and artificial components is envisioned to enable the performance of tasks at a smaller and smaller scale in the future, leading to the parallel and distributed operation of functional systems at the microscale.

  6. Thermo-actuated migration in a micro-system (United States)

    Jullien, Marie-Caroline; Selva, Bertrand; Cantat, Isabelle


    Digital microfluidics require element displacement by simple means featuring high integration rates. Within this context, the transport and handling of elements constitutes a problem [Squires and Quake, 2005]. This context has rekindled interest in the Marangoni surface effect, which refers to tangential stresses along an interface. Producing a surface tension gradient by imposing a temperature gradient is especially efficient and easy to control. In a recent paper, we have shown [Selva et al., Phys. Fluids (2011)] that a bubble undergoing a constant temperature gradient is indeed set into motion. However, the direction of motion (toward the cooler side) is in contradiction with experiments performed at the millimetre scale in which bubble migration is driven towards hoter regions. We believe this observation is due to the PDMS deformability. Indeed, PDMS expands when the temperature increases. A temperature gradient inside a microsystem results in a cavity thickness gradient, and thus leads to the bubble travelling towards the thicker part of the cavity. The physical phenomena involved in such a system are multifaceted (PDMS dilation, thermocapillarity, solutocapillarity) and may have either complementary or opposite effects depending on the experimental conditions.

  7. PREFACE: The Second Conference on Microelectronics, Microsystems and Nanotechnology (United States)

    Nassiopoulou, Androula G.; Papanikolaou, Nikos; Tsamis, Christos


    The Second Conference on Microelectronics, Microsystems and Nanotechnology took place at the National Centre for Scientific Research `Demokritos', in Athens, Greece, between 14 and 17 November 2004. The conference was organized by the Institute of Microelectronics (IMEL) with the aim to bring together scientists and engineers working in the above exciting fields in an interactive forum. The conference included 45 oral presentations with 9 invited papers and was attended by 146 participants from 16 countries. The topics covered were nanotechnologies, quantum devices, sensors, micro- and nano-systems, semiconductor devices, C-MOS fabrication and characterization techniques, new materials, and IC design. Quantum devices and nanostructured materials attracted considerable attention. Both theoretical and experimental studies of metallic and semiconducting quantum systems were presented, with emphasis on their applications in electronics, optoelectronics, and nanocrystal memory devices. Another exciting topic was the recent developments in biocompatible lithographic processes for applications in biosensors. In particular novel processes for bio-friendly lithography, together with innovations in Si sensors for applications in medicine and food industry were presented. Recent developments and perspectives in CMOS technology towards the ultimate limit were also discussed. The conference covered issues and concepts of IC design with two invited talks on RF design and cryptography.The conference included presentations from several companies active in the field of microelectronics and systems in Greece.

  8. Bio-Inspired Microsystem for Robust Genetic Assay Recognition

    Directory of Open Access Journals (Sweden)

    Jaw-Chyng Lue


    Full Text Available A compact integrated system-on-chip (SoC architecture solution for robust, real-time, and on-site genetic analysis has been proposed. This microsystem solution is noise-tolerable and suitable for analyzing the weak fluorescence patterns from a PCR prepared dual-labeled DNA microchip assay. In the architecture, a preceding VLSI differential logarithm microchip is designed for effectively computing the logarithm of the normalized input fluorescence signals. A posterior VLSI artificial neural network (ANN processor chip is used for analyzing the processed signals from the differential logarithm stage. A single-channel logarithmic circuit was fabricated and characterized. A prototype ANN chip with unsupervised winner-take-all (WTA function was designed, fabricated, and tested. An ANN learning algorithm using a novel sigmoid-logarithmic transfer function based on the supervised backpropagation (BP algorithm is proposed for robustly recognizing low-intensity patterns. Our results show that the trained new ANN can recognize low-fluorescence patterns better than an ANN using the conventional sigmoid function.

  9. Restoring visual perception using microsystem technologies: engineering and manufacturing perspectives. (United States)

    Krisch, I; Hosticka, B J


    Microsystem technologies offer significant advantages in the development of neural prostheses. In the last two decades, it has become feasible to develop intelligent prostheses that are fully implantable into the human body with respect to functionality, complexity, size, weight, and compactness. Design and development enforce collaboration of various disciplines including physicians, engineers, and scientists. The retina implant system can be taken as one sophisticated example of a prosthesis which bypasses neural defects and enables direct electrical stimulation of nerve cells. This micro implantable visual prosthesis assists blind patients to return to the normal course of life. The retina implant is intended for patients suffering from retinitis pigmentosa or macular degeneration. In this contribution, we focus on the epiretinal prosthesis and discuss topics like system design, data and power transfer, fabrication, packaging and testing. In detail, the system is based upon an implantable micro electro stimulator which is powered and controlled via a wireless inductive link. Microelectronic circuits for data encoding and stimulation are assembled on flexible substrates with an integrated electrode array. The implant system is encapsulated using parylene C and silicone rubber. Results extracted from experiments in vivo demonstrate the retinotopic activation of the visual cortex.

  10. Features of Microsystems for Cultivation and Characterization of Stem Cells with the Aim of Regenerative Therapy

    Directory of Open Access Journals (Sweden)

    Kihoon Ahn


    Full Text Available Stem cells have infinite potential for regenerative therapy thanks to their advantageous ability which is differentiable to requisite cell types for recovery and self-renewal. The microsystem has been proved to be more helpful to stem cell studies compared to the traditional methods, relying on its advantageous feature of mimicking in vivo cellular environments as well as other profitable features such as minimum sample consumption for analysis and multiprocedures. A wide variety of microsystems were developed for stem cell studies; however, regenerative therapy-targeted applications of microtechnology should be more emphasized and gain more attractions since the regenerative therapy is one of ultimate goals of biologists and bioengineers. In this review, we introduce stem cell researches harnessing well-known microtechniques (microwell, micropattern, and microfluidic channel in view point of physical principles and how these systems and principles have been implemented appropriately for characterizing stem cells and finding possible regenerative therapies. Biologists may gain information on the principles of microsystems to apply them to find solutions for their current challenges, and engineers may understand limitations of the conventional microsystems and find new chances for further developing practical microsystems. Through the well combination of engineers and biologists, the regenerative therapy-targeted stem cell researches harnessing microtechnology will find better suitable treatments for human disorders.

  11. Removal of PCR inhibitors using dielectrophoresis as a selective filter in a microsystem

    DEFF Research Database (Denmark)

    Perch-Nielsen, Ivan Ryberg; Bang, Dang Duong; Poulsen, Claus Riber;


    Diagnostic PCR has been used to analyse a wide range of biological materials. Conventional PCR consists of several steps such as sample preparation, template purification, and PCR amplification. PCR is often inhibited by contamination of DNA templates. To increase the sensitivity of the PCR...... of these components to PCR have been well documented. The usefulness of DEP in a microsystem to withhold baker's yeast (Saccharomyces cerevisiae) cells while the PCR inhibitors haemoglobin and heparin are removed will be presented and factors that influence the effect of DEP in the microsystem will be discussed...

  12. Large concentration changes due to thermal diffusion effects in gas flow microsystems with temperature gradients

    DEFF Research Database (Denmark)

    Quaade, Ulrich; Johannessen, Tue; Jensen, Søren;

    Thermal diffusion, or Sorét diffusion, is shown to cause significant concentration changes and transients in gas flow microsystems with temperature gradients. In a silicon microsystem, a temperature gradient of about 100 oC/mm is measured to produce concentration transients of up to 13.......7 % in an argon/helium mixture, when the flow is abruptly changed from a high value to a low value. Finite element simulations of the thermal diffusion in a geometry similar to the experimental setup reproduce the measurements....

  13. Local Synthesis of Carbon Nanotubes in Silicon Microsystems: The Effect of Temperature Distribution on Growth Structure

    Directory of Open Access Journals (Sweden)

    Knut E. Aasmundtveit


    Full Text Available Local synthesis and direct integration of carbon nanotubes (CNTs into microsystems is a promising method for producing CNT-based devices in a single step, low-cost, and wafer-level, CMOS/MEMS-compatible process. In this report, the structure of the locally grown CNTs are studied by transmission imaging in scanning electron microscopy—S(TEM. The characterization is performed directly on the microsystem, without any post-synthesis processing required. The results show an effect of temperature on the structure of CNTs: high temperature favors thin and regular structures, whereas low temperature favors “bamboo-like” structures.

  14. Bonding technique of polymer layer with ceramic elements of analytical microsystems (United States)

    Chudy, Michał; Malecha, Karol; Golonka, Leszek; Sosicki, Adam; Roguszczak, Henryk; Jakubowska, Małgorzata; Dybko, Artur; Brzózka, Zbigniew


    The possibilities of the construction of microsystems using ceramics and polymers are presented in the paper. The technology of irreversible and reversible bonding of ceramic and polymer microsystems' layers was developed. The irreversible bonding is required only for microfluidic structures, in which samples and reagents are introduced into the system using pressure methods. For the systems with an electroosmotic reagents dosing adhesion forces between particular layers are enough to seal the microchannels. In both cases a glaze layer was screen-printed on ceramic plates to eliminate their surface roughness.

  15. Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem. (United States)

    Weltin, Andreas; Slotwinski, Kinga; Kieninger, Jochen; Moser, Isabella; Jobst, Gerhard; Wego, Marcus; Ehret, Ralf; Urban, Gerald A


    We present a novel, multiparametric microphysiometry system for the dynamic online monitoring of human cancer cell metabolism. The optically transparent, modular, hybrid microsystem is based on a glass chip and combines a cell cultivation chamber, microfluidics and metabolic monitoring with fully integrated chemo- and biosensors. pH and oxygen are measured in the cell culture area, and biosensors for lactate and glucose are connected downstream by microfluidics. The wafer-level fabrication features thin-film platinum and iridium oxide microelectrodes on a glass chip, microfluidics in an epoxy resist, a hybrid assembly and an on-chip reference electrode. The reliable analytical performance of the sensors in cell culture medium was demonstrated. The pH sensors exhibit a long-term stable, linear response. The oxygen sensors show a linear behaviour, which is also observed for low oxygen concentrations. Glucose and lactate measurements show a linear, long-term stable, selective and reversible behaviour in the desired range. T98G human brain cancer cells were cultivated and cell culture metabolism was measured on-chip. Stop/flow cycles were applied and extracellular acidification, respiration, glucose consumption and lactate production were quantified. Long-term metabolic rates were determined and all parameters could be measured in the outlet channel. A placement downstream of the cell cultivation area for biosensors was realised. A highly effective medium exchange and undiluted sampling from the cell culture chamber with low flow rates (2 μl min(-1)) and low volumes (15 μl per cycle) were achieved. The drug screening application was demonstrated by detecting alteration and recovery effects of cellular metabolism induced by the addition of substances to the medium.

  16. Implantable Microsystems for Anatomical Rewiring of Cortical Circuitry: A New Approach for Brain Repair (United States)


    reaching, retrieval of small food items, and locomotion demonstrate that deficits persist during the 5-week recovery period following injury. This will...Implantable microsystem; Neuroplasticity ; Rehabilitation; Traumatic brain injury 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER...we have successfully induced TBI in the CFA, sparing the RFA. Behavioral assessments of reaching, retrieval of small food items, and locomotion

  17. Results of external review Sandia microelectronics and microsystems program (September 2004).

    Energy Technology Data Exchange (ETDEWEB)

    Peercy, Paul S. (University of Wisconsin-Madison, Madision, WI); Myers, David R.


    The US Department of Energy requires a periodic assessment of the Microsystems Program at Sandia National Laboratories. An external review of this program is held approximately every 18 months to 24 months. The report from the External Review Panel serves as the basis for Sandia's ''self assessment'' and is a specific deliverable of the governance contract between Lockheed Martin and the Department of Energy. The External Review of Microelectronics and Microsystems for Fiscal Year 2004 was held September 27-29, 2004 at Sandia National Laboratories, Albuquerque, NM. The external review panel consisted of experts in the fields of microelectronics, photonics and microsystems from universities, industry and other Government agencies. A complete list of the panel members is included as Appendix A of the attached report. The review assessed four areas: relevance to national needs and agency mission; quality of science, technology and engineering; performance in the operation of a major facility; and program performance management and planning. Relevance to national needs and agency mission was rated as ''outstanding''. The quality of science, technology, and engineering was rated as ''outstanding''. Operation of a major facility was rated as ''outstanding'', and the category of program performance, management, and planning was rated as ''outstanding''. Sandia's Microsystems Program thus received an overall rating of ''outstanding'' [the highest possible rating].

  18. Epitaxial integration of nanowires in microsystems by local micrometer-scale vapor-phase epitaxy. (United States)

    Mølhave, Kristian; Wacaser, Brent A; Petersen, Dirch Hjorth; Wagner, Jakob B; Samuelson, Lars; Bøggild, Peter


    Free-standing epitaxially grown nanowires provide a controlled growth system and an optimal interface to the underlying substrate for advanced optical, electrical, and mechanical nanowire device connections. Nanowires can be grown by vapor-phase epitaxy (VPE) methods such as chemical vapor deposition (CVD) or metal organic VPE (MOVPE). However, VPE of semiconducting nanowires is not compatible with several microfabrication processes due to the high synthesis temperatures and issues such as cross-contamination interfering with the intended microsystem or the VPE process. By selectively heating a small microfabricated heater, growth of nanowires can be achieved locally without heating the entire microsystem, thereby reducing the compatibility problems. The first demonstration of epitaxial growth of silicon nanowires by this method is presented and shows that the microsystem can be used for rapid optimization of VPE conditions. The important issue of the cross-contamination of other parts of the microsystem caused by the local growth of nanowires is also investigated by growth of GaN near previously grown silicon nanowires. The design of the cantilever heaters makes it possible to study the grown nanowires with a transmission electron microscope without sample preparation.

  19. Microsystems and Nanoscience for Biomedical Applications: A View to the Future (United States)

    Pilarski, Linda M.; Mehta, Michael D.; Caulfield, Timothy; Kaler, Karan V. I. S.; Backhouse, Christopher J.


    At present there is an enormous discrepancy between our nanotechnological capabilities (particularly our nanobiotechnologies), our social wisdom, and consensus on how to apply them. To date, cost considerations have greatly constrained our application of nanotechnologies. However, novel advances in microsystem platform technologies are about to…

  20. Novel Acoustic Wave Microsystems for Biophysical Studies of Cells (United States)

    Senveli, Sukru Ufuk

    Single cell analysis is an important topic for understanding of diseases. In this understanding, biomechanics approach serves as an important tool as it relates and connects the mechanical properties of biological cells with diseases such as cancer. In this context, analysis methods based on ultrasonics are promising owing to their non-invasive nature and ease of use. However, there is a lack of miniature systems that provide accurate ultrasonic measurements on single cancer cells for diagnostic purposes. The platform presented in this study exploits high frequency acoustic interaction and uses direct coupling of Rayleigh type SAWs with various samples placed inside microcavities to analyze their structural properties. The samples used are aqueous glycerin solutions and polystyrene microbeads for demonstrating proper system operation, and lead up to biological cells. The microcavity is instrumental in trapping a predetermined volume of sample inside and facilitating the interaction of the surface waves with the sample in question via a resonance condition. Ultimately, the resultant SAW reaching the output transducer incurs a phase delay due to its interaction with the sample in the microcavity. The system operates in a different manner compared to similar systems as a result of multiple wave reflections in the small volume and coupling back to the piezoelectric substrate. The proposed microsystem was first analyzed using finite element methods. Liquid and solid media were modeled by considering frequency dependent characteristics. Similarly, mechanical behavior of cells with respect to different conditions is considered, and biological cells are modeled accordingly. Prototype devices were fabricated on quartz and lithium niobate in a cleanroom environment. Process steps were optimized separately for devices with microcavities. Precise fabrication, alignment, and bonding of PDMS microchannels were carried out. Soft microprobes were fabricated out of SU-8, a

  1. Study on Wireless Power Transmission for Gastrointestinal Microsystems Based on Inductive Coupling

    Institute of Scientific and Technical Information of China (English)


    Wireless power transmission based on inductive coupling for remotely implanted micro devices has been considered in this paper. The receiving coil, integrated in microsystems and the external transmitting coil compose a loosely coupled transformer. The coupling coefficient was calculated and measured on spacing misalignments. The geometric size of transmitting coil was analyzed for the target of remotely delivering power. The received power was maximized by choosing appropriate value of frequency, tuning capacitance and the load resistance. A conventional full bridge rectifier circuit was employed to convert ac to dc voltage. The Received dc power was up to 160 mW with a transmitting voltage of 5 Vrms when the receiving coil was placed at the center of the transmitting coil.This may meet the requirement of some microsystems for high power over a long time.

  2. A digital front-end and readout microsystem for calorimetry at LHC--The FERMI project

    Energy Technology Data Exchange (ETDEWEB)

    Dell' Acqua, A.; Hansen, M.; Lofstedt, B.; Vanuxem, J.P. (CERN, Geneva (Switzerland)); Svensson, C.; Yuan, J. (Univ. of Linkoeping (Sweden). Dept. of Physics and Measurement Technology); Hentzell, H. (Univ. of Linkoeping (Sweden). Center for Industrial Microelectronics and Materials Technology); Alippi, C.; Breveglieri, L.; Dadda, L.; Piuri, V.; Salice, F.; Sami, M.; Stefanelli, R. (Sezione INFN, Pavia, Milano (Italy). Dept. di Ellettronica); Cattaneo, P.; Fumagalli, G.; Goggi, V.G. (Univ. e Sezione INFN, Pavia (Italy). Dept. di Fisica Nucleare); Brigati, S.; Gatti, U.; Maloberti, F.; Torelli, G. (Univ. e Sezione INFN, Pavia (Italy). Dept. di Electronica); Carlson, P.; Fuglesang, C.; Kerek, A. (Manne Siegbahn Inst. of Physics, Stockholm (Sweden)); Appelquist, G.; Berglund, S.; Bohm, C.; Yamdagni, N. (Univ. of Stockholm (Sweden)); Sundblad, R. (SiCon AB, Linkoeping (Sweden))


    The authors present a digital solution to the front-end electronics for calorimetric detectors at future supercolliders based on high speed A/D converters, a fully programmable pipeline/digital filter chain and local intelligence. Questions of error correction, fault-tolerance and system redundancy are also considered. A system integration of a multichannel device in a multichip, Silicon-on-Silicon Microsystem hybrid will be used. This solution allows a new level of integration of complex analog and digital functions, with an excellent flexibility in mixing technologies for the different functional blocks. This type of VLSI multichip integration allows a high degree of programmability at both the function and the system level, and offers the possibility of customizing the microsystem with detector-specific functions.

  3. Implementation of an electronic documentation system using microsystem and quality improvement concepts. (United States)

    Rikli, Joan; Huizinga, Beth; Schafer, Dorothea; Atwater, Amy; Coker, Kara; Sikora, Chad


    Electronic documentation systems have become integral to improving the quality of healthcare, reducing medical errors, and advancing the delivery of evidence-based medical care. A smooth transition from paper charting to an electronic documentation system is challenging. Using quality improvement tools and building on the clinical microsystems concept can assist with a smooth transition. Specific strategies include involving all stakeholders in the development and implementation of the plan, assessing the culture of the department, and identifying processes and patterns that require attention. Specific steps include developing a statement of aim, formulating a specific path to reach the aim, evaluating the progress of implementation, and creating a template for future process improvement. This article describes the process used in one midwestern NICU to implement an integrated electronic documentation system using a clinical microsystems approach and quality improvement methods. Challenges encountered and lessons learned are discussed.

  4. A digital Front-End and Readout MIcrosystem for calorimetry at LHC

    CERN Multimedia


    % RD-16 A Digital Front-End and Readout Microsystem for Calorimetry at LHC \\\\ \\\\Front-end signal processing for calorimetric detectors is essential in order to achieve adequate selectivity in the trigger function of an LHC experiment, with data identification and compaction before readout being required in the harsh, high rate environment of a high luminosity hadron machine. Other crucial considerations are the extremely wide dynamic range and bandwidth requirements, as well as the volume of data to be transferred to following stages of the trigger and readout system. These requirements are best met by an early digitalization of the detector information, followed by integrated digital signal processing and buffering functions covering the trigger latencies.\\\\ \\\\The FERMI (Front-End Readout MIcrosystem) is a digital implementation of the front-end and readout electronic chain for calorimeters. It is based on dynamic range compression, high speed A to D converters, a fully programmable pipeline/digital filter c...

  5. Photonic microsystems micro and nanotechnology applied to optical devices and systems

    CERN Document Server

    Solgaard, Olav


    ""Photonic Microsystems: Micro and Nanotechnology Applied to Optical Devices and Systems"", describes MEMS technology and demonstrates how MEMS allow miniaturization, parallel fabrication, and efficient packaging of optics, as well as integration of optics and electronics. It shows how the characteristics of MEMS enable practical implementations of a variety of applications, including projection displays, fiber switches, interferometers, spectrometers. The book describes the phenomenon of Photonic crystals (nanophotonics) and demonstrates how Photonic crystals enable synthesis of materials wit

  6. A new construction of measurement system based on specialized microsystem design for laryngological application (United States)

    Paczesny, Daniel; Mikłaszewicz, Franciszek


    This article describes the design, construction and parameters of diagnostic medical system for air humidity measurement which can be proceeded in various places of human nasal cavities and also human throat. The system can measure dynamic changes of dew point temperature (absolute value of humidity) of inspired and expired air in different places of human upper airways. During regular respiration process dew point temperature is measured in nasal cavity, middle part cavity and nasopharynx. The presented system is the next step in construction of measurement system based on specialized microsystem for laryngological application. The microsystem fabricated on silicon substrate includes microheater, microthermoresistor and interdigitated electrodes. In comparison with previously built measurement system with current version some system functionalities and measurement parameters were improved. Additionally 3D printing technology was applied for rapid prototyping a measurement system housing. Presented measurement system is set of microprocessor module with signal conditioning circuits; heated measurement head based on specialized microsystem with disposable heated pipe for air sucking from various places of upper airways; power supplier and computer application for monitoring all system parameters and presenting on-line and off-line measured results. Some example results of constructed measurement system and dew point temperature measurements during respiration cycle are presented.

  7. Hybrid microsystem with functionalized silicon substrate and PDMS sample operating microchannel: A reconfigurable microfluidics scheme

    Institute of Scientific and Technical Information of China (English)


    A hybrid microsystem with separately functioned temperature controlling substrate and sample operating fluidic microchannel was developed to demonstrate a reconfigurable microfluidics scheme.The temperature controlling substrate integrated a micro heater and a temperature sensor by using traditional silicon-based micromechanical system(MEMS)technique,which guaranteed high performance and robust reliability for repeatable usage.The sample operating fluidic microchannel was prepared by poly-(dimethylsiloxane) (PDMS)based soft lithography technique,which made it cheap enough for disposable applications.The PDMS microchannel chip was attached to the temperature controlling substrate for reconfigurable thermal applications.A thin PDMS film was used to seal the microchannel and bridge the functionalized substrate and the sample inside the channel,which facilitated heat transferring and prevented sample contaminating the temperature controlling substrate.Demonstrated by a one dimensional thermal resistance model,the thin PDMS film was important for the present reconfiguration applications.Thermal performance of this hybrid microsystem was examined,and the experimental results demonstrated that the chip system could work stably over hours with temperature variation less than 0.1oC.Multiple PDMS microchannel chips were tested on one heating substrate sequentially with a maximum intra-chip temperature difference of 1.0oC.DNA extracted from serum of a chronic hepatitis B virus(HBV)patient was amplified by this hybrid microsystem and the gel electrophoresis result indicated that the present reconfigurable microfluidic scheme worked successfully.

  8. Selecting a process paradigm for an emergent disruptive technology: Evidence from the emerging microsystems technology base

    Energy Technology Data Exchange (ETDEWEB)

    Smith, J.H. [Sandia National Labs., Albuquerque, NM (United States). Intelligent Micromachine Dept.; Walsh, S.T. [New Jersey Inst. of Tech., Newark, NJ (United States). School of Industrial Management


    Emergent technologies often suffer from a lack of an installed manufacturing base and an obvious dominant manufacturing technique. Firms which base their search for competitive advantage on emergent disruptive technologies must make hard production choices and endure major manufacturing discontinuities. The authors as well as many other firms, are now facing these challenges with the embrace of microsystems technologies. They add to the literature by providing a set of criteria for firms investing in emergent disruptive technologies. Sandia has long been associated as a pioneer in the development of new manufacturing techniques. Microsystems is just the current in a long line of manufacturing technologies that have been considered for mission critical system applications. The authors as well as others, have had to make the hard choice of investing in specific microsystems manufacturing techniques. Important considerations in the technique choice include: the existing internal manufacturing bases, commonality with existing commercial manufacturing infrastructure, current and projected critical performance characteristics, learning curves, the promise to add new but un-thought-of functionally to existing systems, and the anticipated ability to qualify devices built from the technique for mission critical applications.

  9. High-throughput in situ cell electroporation microsystem for parallel delivery of single guide RNAs into mammalian cells (United States)

    Bian, Shengtai; Zhou, Yicen; Hu, Yawei; Cheng, Jing; Chen, Xiaofang; Xu, Youchun; Liu, Peng


    Arrayed genetic screens mediated by the CRISPR/Cas9 technology with single guide RNA (sgRNA) libraries demand a high-throughput platform capable of transfecting diverse cell types at a high efficiency in a genome-wide scale for detection and analysis of sophisticated cellular phenotypes. Here we developed a high-throughput in situ cell electroporation (HiCEP) microsystem which leveraged the superhydrophobic feature of the microwell array to achieve individually controlled conditions in each microwell and coupled an interdigital electrode array chip with the microwells in a modular-based scheme for highly efficient delivery of exogenous molecules into cells. Two plasmids encoding enhanced green and red fluorescent proteins (EGFP and ERFP), respectively, were successfully electroporated into attached HeLa cells on a 169-microwell array chip with transfection efficiencies of 71.6 ± 11.4% and 62.9 ± 2.7%, and a cell viability above 95%. We also successfully conducted selective electroporation of sgRNA into 293T cells expressing the Cas9 nuclease in a high-throughput manner and observed the four-fold increase of the GFP intensities due to the repair of the protein coding sequences mediated by the CRISPR/Cas9 system. This study proved that this HiCEP system has the great potential to be used for arrayed functional screens with genome-wide CRISPR libraries on hard-to-transfect cells in the future. PMID:28211892

  10. Analysis of river water samples utilising a prototype industrial sensing system for phosphorus based on micro-system technology. (United States)

    Bowden, Michaela; Sequiera, Margaret; Krog, Jens Peter; Gravesen, Peter; Diamond, Dermot


    The application of a phosphorus monitoring device based on microsystems technology (MST) to the analysis of river water is presented. An alternative to the standard molybdenum blue method known as the yellow vanadomolybdophosphoric acid method has been very effectively implemented. The method is simple, a reagent and sample are mixed in a 1:1 ratio forming a yellow complex that absorbs strongly below 400 nm in the UV spectrum. The kinetics of the reaction are rapid and sample turnaround is typically 3 min at room temperature. Therefore a very uncomplicated microfluidic design can be adopted. The working wavelength was chosen as 380 nm to coincide with the peak output of a UV-LED narrow bandwidth light source recently developed by Nichia. The limit of detection for the yellow method in the microfluidic system is 0.2 ppm with a dynamic linear range from 0-50 ppm. The method was applied to a measurement of phosphorus in a local river at specific sampling points along its course.

  11. Electroplating and characterization of cobalt-nickel-iron and nickel-iron for magnetic microsystems applications

    DEFF Research Database (Denmark)

    Rasmussen, Frank Engel; Ravnkilde, Jan Tue; Tang, Peter Torben


    The magnetic properties of pulse reverse (PR) electroplated CoNiFe and DC electroplated NiTe are presented. CoNiFe is a very promising material for magnetic microsystems due to the possibility of achieving a high saturation flux density (B-s) and a low coercivity (H-c). A new bath formulation has...... been developed, which by means of PR electroplating makes it possible to deposit high B-s CoNiFe with a low residual stress level. The magnetic properties have been determined using a new simple measurement setup that allows for wafer level characterization. The results have been validated...

  12. LIGA-based microsystem manufacturing:the electrochemistry of through-mold depostion and material properties.

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, James J. (Sandia National Laboratories, Livermore, CA); Goods, Steven Howard (Sandia National Laboratories, Livermore, CA)


    The report presented below is to appear in ''Electrochemistry at the Nanoscale'', Patrik Schmuki, Ed. Springer-Verlag, (ca. 2005). The history of the LIGA process, used for fabricating dimensional precise structures for microsystem applications, is briefly reviewed, as are the basic elements of the technology. The principal focus however, is on the unique aspects of the electrochemistry of LIGA through-mask metal deposition and the generation of the fine and uniform microstructures necessary to ensure proper functionality of LIGA components. We draw from both previously published work by external researchers in the field as well as from published and unpublished studies from within Sandia.

  13. Epitaxial Integration of Nanowires in Microsystems by Local Micrometer Scale Vapor Phase Epitaxy

    DEFF Research Database (Denmark)

    Mølhave, Kristian; Wacaser, Brent A.; Petersen, Dirch Hjorth;


    Free-standing epitaxially grown nanowires provide a controlled growth system and an optimal interface to the underlying substrate for advanced optical, electrical, and mechanical nanowire device connections. Nanowires can be grown by vapor-phase epitaxy (VPE) methods such as chemical vapor...... deposition (CVD) or metal organic VPE (MOVPE). However, VPE of semiconducting nanowires is not compatible with several microfabrication processes due to the high synthesis temperatures and issues such as cross-contamination interfering with the intended microsystem or the VPE process. By selectively heating...

  14. 20th International Forum on Advanced Microsystems for Automotive Applications

    CERN Document Server

    Müller, Beate; Meyer, Gereon


    This book contains the papers presented at the 20th anniversary edition of the AMAA conference held in Brussels, Belgium in 2016. The theme of the conference was "Smart Systems for the Automobile of the Future". The automobile is currently being reshaped at unprecedented pace. Automation and electrification are the two dominant megatrends which dramatically change the choice and design of components, systems, vehicular architectures and ultimately the way we use cars in the coming decades. Novel E/E architectures, vehicular connectivity and cloud services will be key to extending the perception and decision-making horizons of automated vehicles, to enable cooperative functions and a seamless digital user experience. The AMAA's ongoing mission to detect novel trends in automotive ICT, electronics and smart systems and to discuss the technological implications is once again reflected in this volume. The book will be a valuable read for research experts and professionals in the automotive and smart systems indus...

  15. Bio-inspired polymeric patterns with enhanced wear durability for microsystem applications

    Energy Technology Data Exchange (ETDEWEB)

    Singh, R. Arvind; Siyuan, L.; Satyanarayana, N. [Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576 (Singapore); Kustandi, T.S. [Institute of Materials Research and Engineering, A-STAR, 3 Research Link, Singapore 117602 (Singapore); Sinha, Sujeet K., E-mail: [Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576 (Singapore)


    At micro/nano-scale, friction force dominates at the interface between bodies moving in relative motion and severely affects their smooth operation. This effect limits the performance of microsystem devices such as micro-electro-mechanical systems (MEMS). In addition, friction force also leads to material removal or wear and thereby reduces the durability i.e. the useful operating life of the devices. In this work, we fabricated bio-inspired polymeric patterns for tribological applications. Inspired by the surface features on lotus leaves namely, the protuberances and wax, SU-8 polymeric films spin-coated on silicon wafers were topographically and chemically modified. For topographical modification, micro-scale patterns were fabricated using nanoimprint lithography and for chemical modification, the micro-patterns were coated with perfluoropolyether nanolubricant. Tribological investigation of the bio-inspired patterns revealed that the friction coefficients reduced significantly and the wear durability increased by several orders. In order to enhance the wear durability much further, the micro-patterns were exposed to argon/oxygen plasma and were subsequently coated with the perfluoropolyether nanolubricant. Bio-inspired patterns with enhanced wear durability, such as the ones investigated in the current work, have potential tribological applications in MEMS/Bio-MEMS actuator-based devices. Highlights: {yields}Bio-inspired polymeric patterns for tribological applications in microsystems. {yields}Novel surface modification for the patterns to enhance tribological properties. {yields}Patterns show low friction properties and extremely high wear durability.

  16. Final report on LDRD project : narrow-linewidth VCSELs for atomic microsystems.

    Energy Technology Data Exchange (ETDEWEB)

    Chow, Weng Wah; Geib, Kent Martin; Peake, Gregory Merwin; Serkland, Darwin Keith


    Vertical-cavity surface-emitting lasers (VCSELs) are well suited for emerging photonic microsystems due to their low power consumption, ease of integration with other optical components, and single frequency operation. However, the typical VCSEL linewidth of 100 MHz is approximately ten times wider than the natural linewidth of atoms used in atomic beam clocks and trapped atom research, which degrades or completely destroys performance in those systems. This report documents our efforts to reduce VCSEL linewidths below 10 MHz to meet the needs of advanced sub-Doppler atomic microsystems, such as cold-atom traps. We have investigated two complementary approaches to reduce VCSEL linewidth: (A) increasing the laser-cavity quality factor, and (B) decreasing the linewidth enhancement factor (alpha) of the optical gain medium. We have developed two new VCSEL devices that achieved increased cavity quality factors: (1) all-semiconductor extended-cavity VCSELs, and (2) micro-external-cavity surface-emitting lasers (MECSELs). These new VCSEL devices have demonstrated linewidths below 10 MHz, and linewidths below 1 MHz seem feasible with further optimization.

  17. Optofluidic microsystem for on-chip L2-waveguide modulation featuring flow stabilization and a novel input coupling region

    NARCIS (Netherlands)

    Weber, E.; Rosenauer, M.; Verhaert, P.D.E.M.; Vellekoop, M.J.


    We present an optofluidic microsystem integrated onto a single device featuring on-chip light guiding and positioning under stable and low-loss conditions. Integration of optical components onto a microfluidic chip offers numerous new possibilities in the field of particle and cell analysis, but rec

  18. Biomedical microsystems

    CERN Document Server

    Meng, Ellis


    IntroductionEvolution of MEMSApplications of MEMSBioMEMS ApplicationsMEMS ResourcesText Goals and OrganizationMiniaturization and ScalingBioMEMS MaterialsTraditional MEMS and Microelectronic MaterialsPolymeric Materials for MEMSBiomaterialsMicrofabrication Methods and Processes for BioMEMSIntroductionMicrolithographyDopingMicromachiningWafer Bonding, Assembly, and PackagingSurface TreatmentConversion Factors for Energy and Intensity UnitsLaboratory ExercisesMicrofluidicsIntroduction and Fluid PropertiesConcepts in MicrofluidicsFluid-Transport Phenomena and PumpingFlow ControlLaboratory Exercis

  19. The BioSentinel Bioanalytical Microsystem: Characterizing DNA Radiation Damage in Living Organisms Beyond Earth Orbit (United States)

    Ricco, A. J.; Hanel, R.; Bhattacharya, S.; Boone, T.; Tan, M.; Mousavi, A.; Rademacher, A.; Schooley, A.; Klamm, B.; Benton, J.; Padgen, M.; Gentry, D.; Friedericks, C.; Defouw, G.; Parra, M.; Santa Maria, S.; Marina, D.; Swan, B. G.; Wheeler, S.; Gavalas, S.; Lewis, B.; Sanchez, H.; Chartres, J.; Lusby, T.


    We will present details and initial lab test results from an integrated bioanalytical microsystem designed to conduct the first biology experiments beyond low Earth orbit (LEO) since Apollo 17 (1972). The 14-kg, 12x24x37-cm BioSentinel spacecraft (Figure 1) assays radiation-responsive yeast in its science payload by measuring DNA double-strand breaks (DSBs) repaired via homologous recombination, a mechanism common to all eukaryotes including humans. S. cerevisiae (brewer's yeast) in 288 microwells are provided with nutrient and optically assayed for growth and metabolism via 3-color absorptimetry monthly during the 18-month mission. BioSentinel is one of several secondary payloads to be deployed by NASA's Exploration Mission 1 (EM-1) launch vehicle into approximately 0.95 AU heliocentric orbit in July 2018; it will communicate with Earth from up to 100 million km.

  20. A microsystem integration platform dedicated to build multi-chip-neural interfaces. (United States)

    Ayoub, Amer E; Gosselin, Benoit; Sawan, Mohamad


    In this paper, we present an electrical discharge machining (EDM) technique associated with electrochemical steps to construct an appropriate biological interface to neural tissues. The presented microprobe design permits to short the time of production compared to available techniques, while improving the integrity of the electrodes. In addition, we are using a 3D approach to create compact and independent microsystem integration platefrom incorporating array of electrodes and signal processing chips. System-in-package and die-stacking are used to connect the integrated circuits and the array of electrodes on the platform. This approach enables to build a device that will fit in a volume smaller than 1.7 x 1.7 x 3.0 mm(3). This demonstrates the possibility of creating small devices that are suitable to fit in restricted areas for interfacing the brain.

  1. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells. (United States)

    Wang, Xue-Ying; Pei, Ying; Xie, Min; Jin, Zi-He; Xiao, Ya-Shi; Wang, Yang; Zhang, Li-Na; Li, Yan; Huang, Wei-Hua


    Reproducing a tumor microenvironment consisting of blood vessels and tumor cells for modeling tumor invasion in vitro is particularly challenging. Here, we report an artificial blood vessel implanted 3D microfluidic system for reproducing transvascular migration of tumor cells. The transparent, porous and elastic artificial blood vessels are obtained by constructing polysaccharide cellulose-based microtubes using a chitosan sacrificial template, and possess excellent cytocompatibility, permeability, and mechanical characteristics. The artificial blood vessels are then fully implanted into the collagen matrix to reconstruct the 3D microsystem for modeling transvascular migration of tumor cells. Well-defined simulated vascular lumens were obtained by proliferation of the human umbilical vein endothelial cells (HUVECs) lining the artificial blood vessels, which enables us to reproduce structures and functions of blood vessels and replicate various hemodynamic parameters. Based on this model, the adhesion and transvascular migration of tumor cells across the artificial blood vessel have been well reproduced.

  2. White light interferometer with color CCD for 3D-surface profiling of microsystems (United States)

    Upputuri, Paul K.; Pramanik, Manojit; Nandigana, Krishna M.; Kothiyal, Mahendra P.


    White light interferometry (WLI) is a state-of-the-art technique for high resolution full-filed 3-D surface profiling of Microsystems. However, the WLI is rather slow, because the number of frames to be recorded and evaluated is large compared to the single wavelength phase shifting interferometry. In this paper, we combine white light interferometer with a single-chip color CCD camera which makes the measurement faster, simpler, and cost-effective. The red-bluegreen (RGB) color interferogram stored in a computer is then decomposed into its individual components and corresponding phase maps for red, green, and blue components are calculated independently. The usefulness of the technique is demonstrated on reflective micro-scale-samples.

  3. Microsystems enabled photovoltaics: 14.9% efficient 14 {mu}m thick crystalline silicon solar cell

    Energy Technology Data Exchange (ETDEWEB)

    Cruz-Campa, Jose L. [Sandia National Laboratories, M.S. 1080, 1515 Eubank Blvd. SE, Albuquerque, NM 87123 (United States); University of Texas at El Paso, Department of Electrical and Computer Engineering, 500 West University Avenue, El Paso, TX 79968 (United States); Okandan, Murat; Resnick, Paul J.; Clews, Peggy; Pluym, Tammy; Grubbs, Robert K.; Gupta, Vipin P.; Nielson, Gregory N. [Sandia National Laboratories, M.S. 1080, 1515 Eubank Blvd. SE, Albuquerque, NM 87123 (United States); Zubia, David [University of Texas at El Paso, Department of Electrical and Computer Engineering, 500 West University Avenue, El Paso, TX 79968 (United States)


    Crystalline silicon solar cells 10-15 times thinner than traditional commercial c-Si cells with 14.9% efficiency are presented with modeling, fabrication, and testing details. These cells are 14 {mu}m thick, 250 {mu}m wide, and have achieved 14.9% solar conversion efficiency under AM 1.5 spectrum. First, modeling results illustrate the importance of high-quality passivation to achieve high efficiency in thin silicon, back contacted solar cells. Then, the methodology used to fabricate these ultra thin devices by means of established microsystems processing technologies is presented. Finally, the optimization procedure to achieve high efficiency as well as the results of the experiments carried out with alumina and nitride layers as passivation coatings are discussed. (author)

  4. Advanced modeling and simulation to design and manufacture high performance and reliable advanced microelectronics and microsystems.

    Energy Technology Data Exchange (ETDEWEB)

    Nettleship, Ian (University of Pittsburgh, Pittsburgh, PA); Hinklin, Thomas; Holcomb, David Joseph; Tandon, Rajan; Arguello, Jose Guadalupe, Jr. (,; .); Dempsey, James Franklin; Ewsuk, Kevin Gregory; Neilsen, Michael K.; Lanagan, Michael (Pennsylvania State University, University Park, PA)


    An interdisciplinary team of scientists and engineers having broad expertise in materials processing and properties, materials characterization, and computational mechanics was assembled to develop science-based modeling/simulation technology to design and reproducibly manufacture high performance and reliable, complex microelectronics and microsystems. The team's efforts focused on defining and developing a science-based infrastructure to enable predictive compaction, sintering, stress, and thermomechanical modeling in ''real systems'', including: (1) developing techniques to and determining materials properties and constitutive behavior required for modeling; (2) developing new, improved/updated models and modeling capabilities, (3) ensuring that models are representative of the physical phenomena being simulated; and (4) assessing existing modeling capabilities to identify advances necessary to facilitate the practical application of Sandia's predictive modeling technology.

  5. Using a co-culture microsystem for cell migration under fluid shear stress. (United States)

    Yeh, Chia-Hsien; Tsai, Shen-Hsing; Wu, Li-Wha; Lin, Yu-Cheng


    We have successfully developed a microsystem to co-cultivate two types of cells with a minimum defined gap of 50 μm, and to quantitatively study the impact of fluid shear stress on the mutual influence of cell migration velocity and distance. We used the hydrostatic pressure to seed two different cells, endothelial cells (ECs) and smooth muscle cells (SMCs), on opposite sides of various gap sizes (500 μm, 200 μm, 100 μm, and 50 μm). After cultivating the cells for 12 h and peeling the co-culture microchip from the culture dish, we studied the impacts of gap size on the migration of either cell type in the absence or presence of fluid shear stress (7 dyne cm(-2) and 12 dyne cm(-2)) influence. We found that both gap size and shear stress have profound influence on cell migration. Smaller gap sizes (100 μm and 50 μm) significantly enhanced cell migration, suggesting a requirement of an effective concentration of released factor(s) by either cell type in the gap region. Flow-induced shear stress delayed the migration onset of either cell type in a dose-dependent manner regardless of the gap size. Moreover, shear stress-induced decrease of cell migration becomes evident when the gap size was 500 μm. We have developed a co-culture microsystem for two kinds of cells and overcome the conventional difficulties in observation and mixed culture, and it would have more application for bio-manipulation and tissue repair engineering.

  6. Screen printing as a holistic manufacturing method for multifunctional microsystems and microreactors (United States)

    Bejarano, D.; Lozano, P.; Mata, D.; Cito, S.; Constantí, M.; Katakis, I.


    Microsystems are commonly manufactured by photolithographic or injection moulding techniques in a variety of realizations and on almost any material. A perennial problem in the manufacturing of microsystems is the difficulty to obtain hybrid devices that incorporate distinct materials with different functionalities. In most of the cases, cumbersome prototyping and high investment needed for manufacturing are additional problems that add to the cost of the final product. Such drawbacks are true not only for lab-on-a-chip but also for certain microreactor applications. Most importantly, in many commercial applications where an intermediate product between full fluidics control and a 'strip' is needed, such restraints prohibit the feasibility of reduction to practice. Screen printing on the other hand is a low cost technique that has been used for years in mass producing two-dimensional low cost reproductions of a mask pattern for circuits and art incorporates prototyping in production and allows the use of an almost limitless variety of materials as 'inks'. In this work it is demonstrated that taking advantage of the deposited ink's three-dimensional nature, screen printing can be used as a versatile and low cost technique for the fabrication of microchannels. Microchannels with dimensions in the order of 100 µm were fabricated that could readily incorporate functionalities through the choice of the materials used to create the microstructure. Variables have been investigated through a factorial experimental design as important process parameters that affect the resolution and print thickness of the resulting microchannels that incorporate electroactive elements. Such studies can lead to the optimization of the process for custom applications.

  7. Superamphiphobic Silicon-Nanowire-Embedded Microsystem and In-Contact Flow Performance of Gas and Liquid Streams. (United States)

    Ko, Dong-Hyeon; Ren, Wurong; Kim, Jin-Oh; Wang, Jun; Wang, Hao; Sharma, Siddharth; Faustini, Marco; Kim, Dong-Pyo


    Gas and liquid streams are invariably separated either by a solid wall or by a membrane for heat or mass transfer between the gas and liquid streams. Without the separating wall, the gas phase is present as bubbles in liquid or, in a microsystem, as gas plugs between slugs of liquid. Continuous and direct contact between the two moving streams of gas and liquid is quite an efficient way of achieving heat or mass transfer between the two phases. Here, we report a silicon nanowire built-in microsystem in which a liquid stream flows in contact with an underlying gas stream. The upper liquid stream does not penetrate into the lower gas stream due to the superamphiphobic nature of the silicon nanowires built into the bottom wall, thereby preserving the integrity of continuous gas and liquid streams, although they are flowing in contact. Due to the superamphiphobic nature of silicon nanowires, the microsystem provides the best possible interfacial mass transfer known to date between flowing gas and liquid phases, which can achieve excellent chemical performance in two-phase organic syntheses.

  8. ac-Field-induced fluid pumping in microsystems with asymmetric temperature gradients. (United States)

    Holtappels, Moritz; Stubbe, Marco; Gimsa, Jan


    We present two different designs of electrohydrodynamic micropumps for microfluidic systems. The micropumps have no movable parts, and their simple design allows for fabrication by microsystems technology. The pumps are operated by ac voltages from 1 to 60 V and were tested with aqueous solutions in the conductivity range of 1-112 mS m(-1). The pump effect is induced by an ac electric field across a fluid medium with an inhomogeneous temperature distribution. It is constant over a wide range of the ac field frequency with a conductivity-dependent drop-off at high frequencies. The temperature-dependent conductivity and permittivity distributions in the fluid induce space charges that interact with the electric field and induce fluid motion. The temperature distribution can be generated either by Joule heating in the medium or by external heating. We present experimental results obtained with two prototypes featuring Joule heating and external heating by a heating filament. Experimental and numerical results are compared with an analytical model.

  9. The risk and protective functions of perceived family and peer microsystems among urban adolescents in poverty. (United States)

    Seidman, E; Chesir-Teran, D; Friedman, J L; Yoshikawa, H; Allen, L; Roberts, A; Aber, J L


    Utilized a pattern-based approach to discover the different constellations of perceived social transactions separately for family and peer systems and explored the risk and protective functions of these microsystem profiles for both depression and antisocial behavior among a sample of ethnically and racially diverse urban adolescents living in poverty. Measures of perceived social support, involvement and hassles with family and peers, as well as perceived social acceptance and peers' values were entered into two sets of iterative cluster analyses to identify distinct profiles of family and peer transactions. From each of the perceived family and peer transactional analyses, six replicated profiles emerged. Several of the profiles were consistent with expectations from prior literature such as Enmeshing families and Rejecting peer networks, while others were novel and intriguing such as Entangling peers. Family profiles were consistent in their risk and protective associations for both depression and antisocial behavior, while the peer profiles varied in their effects for each developmental outcome. For example, the Rejecting peer profile placed adolescents at increased risk for depression but protected them from antisocial behavior. Implications for future research and preventive intervention are discussed.

  10. Biocompatible circuit-breaker chip for thermal management of biomedical microsystems (United States)

    Luo, Yi; Dahmardeh, Masoud; Takahata, Kenichi


    This paper presents a thermoresponsive micro circuit breaker for biomedical applications specifically targeted at electronic intelligent implants. The circuit breaker is micromachined to have a shape-memory-alloy cantilever actuator as a normally closed temperature-sensitive switch to protect the device of interest from overheating, a critical safety feature for smart implants including those that are electrothermally driven with wireless micro heaters. The device is fabricated in a size of 1.5  ×  2.0  ×  0.46 mm3 using biocompatible materials and a chip-based titanium package, exhibiting a nominal cold-state resistance of 14 Ω. The breaker rapidly enters the full open condition when the chip temperature exceeds 63 °C, temporarily breaking the circuit of interest to lower its temperature until chip temperature drops to 51 °C, at which the breaker closes the circuit to allow current to flow through it again, physically limiting the maximum temperature of the circuit. This functionality is tested in combination with a wireless resonant heater powered by radio-frequency electromagnetic radiation, demonstrating self-regulation of heater temperature. The developed circuit-breaker chip operates in a fully passive manner that removes the need for active sensor and circuitry to achieve temperature regulation in a target device, contributing to the miniaturization of biomedical microsystems including electronic smart implants where thermal management is essential.

  11. Preliminary Investigation of an SOI-based Arrayed Waveguide Grating Demodulation Integration Microsystem (United States)

    Li, Hongqiang; Zhou, Wenqian; Liu, Yu; Dong, Xiaye; Zhang, Cheng; Miao, Changyun; Zhang, Meiling; Li, Enbang; Tang, Chunxiao


    An arrayed waveguide grating (AWG) demodulation integration microsystem is investigated in this study. The system consists of a C-band on-chip LED, a 2 × 2 silicon nanowire-based coupler, a fiber Bragg grating (FBG) array, a 1 × 8 AWG, and a photoelectric detector array. The coupler and AWG are made from silicon-on-insulator wafers using electron beam exposure and response-coupled plasma technology. Experimental results show that the excess loss in the MMI coupler with a footprint of 6 × 100 μm2 is 0.5423 dB. The 1 × 8 AWG with a footprint of 267 × 381 μm2 and a waveguide width of 0.4 μm exhibits a central channel loss of −3.18 dB, insertion loss non-uniformity of −1.34 dB, and crosstalk level of −23.1 dB. The entire system is preliminarily tested. Wavelength measurement precision is observed to reach 0.001 nm. The wavelength sensitivity of each FBG is between 0.04 and 0.06 nm/dB. PMID:24797561

  12. Medical capability team: the clinical microsystem for combat healthcare delivery in counterinsurgency operations. (United States)

    Clark, Susz; Van Steenvort, Jon K


    Today's operational environment in the support of counterinsurgency operations requires greater tactical and operational flexibility and diverse medical capabilities. The skills and organizations required for full spectrum medical operations are different from those of the past. Combat healthcare demands agility and the capacity for rapid change in clinical systems and processes to better support the counterinsurgency environment. This article proposes the Army Medical Department (AMEDD) develop and implement the medical capability team (MCT) for combat healthcare delivery. It discusses using the concept of the brigade combat team to develop medical capability teams as the unit of effectiveness to transform frontline care; provides a theoretical overview of the MCT as a "clinical microsystem"; discusses MCT leadership, training, and organizational support, and the deployment and employment of the MCT in a counterinsurgency environment. Additionally, this article proposes that the AMEDD initiate the development of an AMEDD Combat Training Center of Excellence to train and validate the MCTs. The complexity of combat healthcare demands an agile and campaign quality AMEDD with joint expeditionary capability in order to promote the best patient outcomes in a counterinsurgency environment.

  13. Innovative optical microsystem for static and dynamic tissue diagnosis in minimally invasive surgical operations (United States)

    Ahmadi, Roozbeh; Packirisamy, Muthukumaran; Dargahi, Javad


    During conventional surgical tasks, surgeons use their tactile perception in their finger tips to sense the degree of softness of biological tissues to identify tissue types and to feel for any abnormalities. However, in robotic-assisted surgical systems, surgeons are unable to sense this information because only surgical tools interact with tissues. In order to provide surgeons with such useful tactile perception, therefore, a tactile sensor is required that is capable of simultaneously measuring contact force and resulting tissue deformation. Accordingly, this paper discusses the design, prototyping, testing, and validation of an innovative tactile sensor that is capable of measuring the degree of softness of soft objects such as tissues under both static and dynamic loading conditions and which is also magnetic resonance compatible and electrically passive. These unique characteristics of the proposed sensor would also make it a practical choice for use in robotic-assisted surgical platforms. The prototype version of this sensor was developed by using optical micro-systems technology and, thus far, experimental test results performed on the prototyped sensor have validated its ability to measure the relative softness of artificial tissues.

  14. Some metal oxides and their applications for creation of Microsystems (MEMS) and Energy Harvesting Devices (EHD) (United States)

    Denishev, K.


    This is a review of a part of the work of the Technological Design Group at Technical University of Sofia, Faculty of Electronic Engineering and Technologies, Department of Microelectronics. It is dealing with piezoelectric polymer materials and their application in different microsystems (MEMS) and Energy Harvesting Devices (EHD), some organic materials and their applications in organic (OLED) displays, some transparent conductive materials etc. The metal oxides Lead Zirconium Titanate (PZT) and Zinc Oxide (ZnO) are used as piezoelectric layers - driving part of different sensors, actuators and EHD. These materials are studied in term of their performance in dependence on the deposition conditions and parameters. They were deposited as thin films by using RF Sputtering System. As technological substrates, glass plates and Polyethylenetherephtalate (PET) foils were used. For characterization of the materials, a test structure, based on Surface Acoustic Waves (SAW), was designed and prepared. The layers were characterized by Fourier Transform Infrared spectroscopy (FTIR). The piezoelectric response was tested at variety of mechanical loads (tensile strain, stress) in static and dynamic (multiple bending) mode. The single-layered and double-layered structures were prepared for piezoelectric efficiency increase. A structure of piezoelectric energy transformer is proposed and investigated.

  15. Synthesis of analog behavioral models of variable complexity for use in simulation of electronic circuits associated with microsystems

    CERN Document Server

    Boucher, J; Ayoub, K I; Cousineau, S M; Ahmadpanah, M; Rakotondrazafy, C; Harchani, N; Andreu, D; Montagner, L; Marin, M


    The analog behavioral modeling must constitute a privileged axis of research for a global simulation of systems and micro-systems. This paper presents a research/education (R&E) methodology which has been developed by the authors as a result of many years of experience in the domains of electronic components, circuits and systems, in different university and industrial research laboratories. It concerns the entire constitutive analog functions, used in the processing of energy and information, with different abstraction levels, extending from a simple component to complex macro-functions used in system electronics. (10 refs).

  16. Air-core microcavities and metal-dielectric filters - building blocks for optofluidic microsystems (United States)

    Allen, Trevor Warren

    This thesis describes a study on two optical devices intended to be building blocks for the creation of integrated optical/microfluidic lab-on-a-chip systems. First, arrays of curved-mirror dome-shaped microcavities were fabricated by buckling self-assembly of a-Si/SiO2 multilayers. This novel technique employs controlled, stress-induced film delamination to form highly symmetric cavities with minimal roughness defects or geometrical imperfections. Measured cavity heights were in good agreement with predictions from elastic buckling theory. Also, the measured finesse (> 103) and quality factor (> 104 in the 1550-nm range) were close to reflectance-limited predictions, indicating low defects and roughness. Hermite- and Laguerre-Gaussian modes were observable, indicating a high degree of cylindrical symmetry. In the second part of the research, transmittance in periodic metal-dielectric multilayer structures was studied. Metal-dielectric stacks have many potential applications in optofluidic microsystems, including as transmission filters, superlenses, and substrates for surface plasmon sensors. In this work, we showed that potential transmittance theory provides a good method for describing the tunneling of photons through metal-dielectric stacks, for both Fabry-Perot and surface plasmon resonances. This approach explains the well-known fact that for a given thickness of metal, subdividing the metal into several thin films can increase the maximum transmittance. Conditions for admittance matching of dielectric-metal-dielectric unit cells to an external air medium were explored for Fabry-Perot based tunneling, revealing that thicker metal films require higher-index dielectrics for optimal admittance matching. It was also shown for the first time that potential transmittance theory can be used to predict the maximum possible transmittance in surface-plasmon-mediated tunneling. In a subsequent study, potential transmittance was used to derive an expression for

  17. Water pollution analysis and detection. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning water pollution analysis, detection, monitoring, and regulation. Citations review online systems, bioassay monitoring, laser-based detection, sensor and biosensor systems, metabolic analyzers, and microsystem techniques. References cover fiber-optic portable detection instruments and rapid detection of toxicants in drinking water. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  18. The Development of Microsystems and New Applications of Electrochemistry%微系统科技的发展及电化学的新应用

    Institute of Scientific and Technical Information of China (English)

    田昭武; 林华水; 孙建军; 周勇亮; 祖延斌; 田中群; 罗瑾; 林仲华; 谢兆雄; 胡维玲; 胡涌刚; 苏文煅


    1 )Brief introduction to microsystems. 2)Discussio ns on the developments of microsystem technologies. 3)Applications of electrochemistry in microsystem: Confined Etchant Layer Technique (CELT) for the complex 3D-pattern micromachining; Focusing Electrophoresis and the application of microsystem in (bio) chemistry (μTAS or Lab on A Chip) ;Smart Electro-Osmosis pump a reasonable choosing for microfluidic network. 4)Concluding remark.%根据田昭武在中国化学会第一届全国纳米技术与应用会议(2000.11.28,厦门)特邀大会报告内容整理而成:1)微系统技术概述(技术的必要性和前景);2)发展微系统技术的特殊困难;3)电化学在微系统技术中的应用,包括用于复杂3D-图形微加工的约束刻蚀剂层技术(CELT);聚焦电泳和微系统在(生物)化学中的应用(μ-TAS或芯片上实验室);芯片实验室中微流体输运网络的合理选择之一-灵巧(Smart)电渗泵;4)结论.

  19. 3D Packaging for Microsystems%微系统三维(3D)封装技术

    Institute of Scientific and Technical Information of China (English)



    文章论述塑料三维(3D)结构微系统封装技术相关问题,描述了把微电机硅膜泵与3D塑料密封垂直多芯片模块封装(MCM-V)相结合的微系统集成化。采用有限元技术分析封装结构中的封装应力,根据有限元设计研究结果,改变芯片载体结构,降低其发生裂纹的危险。计划采用板上芯片和塑料无引线芯片载体的替代低应力和低成本的3D封装技术方案。%Issues associated with the packaging of microsystems in plastic and three-dimensional (3D) body styles are discussed. The integration of a microsystem incorporating a micromachined silicon membrane pump into a 3D plastic encapsulated vertical multichip module package (MCM-V) is described. Finite element techniques are used to analyze the encapsulation stress in the structure of the package. Cracks develop in the chip carrier due to thermornechanical stress. Based on the results of a finite element design study, the structures of the chip carriers are modified to reduce their risk of cracking. Alternative low stress 3D packaging methodologies based on chip on board and plastic leadless chip carriers are discussed.

  20. Hydronyms Ending in -zha (-жа in the Russian North-West (Structure, Etymology, Microsystemic Ties, Linguo-Ethnic Attribution

    Directory of Open Access Journals (Sweden)

    Valery L. Vasilyev


    Full Text Available The article deals with river and lake-names ending in -zha in the Russian North-West, notably on the historical territories of Novgorod, Pskov and Toropets, analyzing the abovementioned hydronyms in the structural, derivational, microsystemic, semantic, etymological and lingo-ethnic aspects. The study of the names in question soundly reveals the basic ancient strata of the region: Slavic, Baltic and Finno-Ugric.

  1. The Development of Microsystems and New Applications of Electrochemistry%微系统科技的发展及电化学的新应用

    Institute of Scientific and Technical Information of China (English)

    田昭武; 林华水; 孙建军; 周勇亮; 祖延斌; 田中群; 罗瑾; 林仲华; 谢兆雄; 胡维玲; 胡涌刚; 苏文煅


    本文根据田昭武在中国化学会第一届全国纳米技术与应用会议(2000.11.28,厦门)特邀大会报告内容整理而成:   1 微系统技术概述(技术的必要性和前景)   2 发展微系统技术的特殊困难   3 电化学在微系统技术中的应用    3.1 用于复杂3D-图形微加工的约束刻蚀剂层技术(CELT)    3.2 聚焦电泳和微系统在(生物)化学中的应用(μ-TAS或芯片上实验室)    3.3 芯片实验室中微流体输运网络的合理选择之一-灵巧(Smart)电渗泵   4 结论%1 Brief introduction to microsystems   2 Discussions on the developments of microsystem technologies   3 Applications of electrochemistry in microsystem    3.1 Confined Etchant Layer Technique (CELT) for the complex 3D-pattern micromachining    3.2 Focusing Electrophoresis and the application of microsystem in (bio) chemistry (μTAS or Lab on A Chip)    3.3 Smart Electro-Osmosis pump——a reasonable choosing for microfluidic network   4 Concluding remark

  2. New Effective Material Couple--Oxide Ceramic and Carbon Nanotube-- Developed for Aerospace Microsystem and Micromachine Technologies (United States)

    Miyoshi, Kazuhisa; VanderWal, Randall L.; Tomasek, Aaron J.; Sayir, Ali; Farmer, Serene C.


    The prime driving force for using microsystem and micromachine technologies in transport vehicles, such as spacecraft, aircraft, and automobiles, is to reduce the weight, power consumption, and volume of components and systems to lower costs and increase affordability and reliability. However, a number of specific issues need to be addressed with respect to using microsystems and micromachines in aerospace applications--such as the lack of understanding of material characteristics; methods for producing and testing the materials in small batches; the limited proven durability and lifetime of current microcomponents, packaging, and interconnections; a cultural change with respect to system designs; and the use of embedded software, which will require new product assurance guidelines. In regards to material characteristics, there are significant adhesion, friction, and wear issues in using microdevices. Because these issues are directly related to surface phenomena, they cannot be scaled down linearly and they become increasingly important as the devices become smaller. When microsystems have contacting surfaces in relative motion, the adhesion and friction affect performance, energy consumption, wear damage, maintenance, lifetime and catastrophic failure, and reliability. Ceramics, for the most part, do not have inherently good friction and wear properties. For example, coefficients of friction in excess of 0.7 have been reported for ceramics and ceramic composite materials. Under Alternate Fuels Foundation Technologies funding, two-phase oxide ceramics developed for superior high-temperature wear resistance in NASA's High Operating Temperature Propulsion Components (HOTPC) project and new two-layered carbon nanotube (CNT) coatings (CNT topcoat/iron bondcoat/quartz substrate) developed in NASA's Revolutionary Aeropropulsion Concepts (RAC) project have been chosen as a materials couple for aerospace applications, including micromachines, in the nanotechnology

  3. EDITORIAL: Special section: Selected papers from OMS'05, the 1st Topical Meeting of the European Optical Society on Optical Microsystems (OMS) (United States)

    Rendina, Ivo; Fazio, Eugenio; Ferraro, Pietro


    OMS'05 is the first international conference wholly dedicated to optical microsystems. It was organized by the European Optical Society (EOS) in the frame of its international topical meeting activity and was held in Italy, September 2005, amidst the wonderful scenery of the Island of Capri. A possible definition of an optical microsystem is a complex system, able to perform one or more sensing and actuation functions, where optical devices are integrated in a smart way with electronic, mechanical and sensing components by taking advantage of the progress in micro- and nano-technologies. The increasing interest in this field arises from the expected applications that would significantly improve the quality of life. The list of possibilities offered by the optical microsystem enabling technologies is very long and seems to increase day by day. We are not only thinking about the next generation of optical telecommunication networks and computers, but also about low-cost, compact microsystems for environmental monitoring, in order to improve safety in the avionic and automotive fields, medical diagnostics and proteomic/genomic studies, or just finding general applications in several industrial fields. The goal of the conference was to involve scientists and young researchers from the main public and private laboratories, giving them the opportunity to present new scientific results and compare their know-how in the exciting and emerging field of optical microsystems. We believe that we succeeded in this. More than 200 scientists from all over the world attended the conference. We had more than 100 oral presentations and approximately 20 from the keynote lectures and invited speeches. It was an opportunity to define the most recent progress carried out in the field and to outline the possible road-map leading to the expected results in the industrial and social fields. We strongly believe that research and technology are closely interconnected at present and cannot

  4. A hybrid poly(dimethylsiloxane) microsystem for on-chip whole blood filtration optimized for steroid screening. (United States)

    Thorslund, Sara; Klett, Oliver; Nikolajeff, Fredrik; Markides, Karin; Bergquist, Jonas


    Miniaturized biochemical devices in glass, silicon and polymer materials are starting to find their way from the academic laboratories to real-life applications. However, most attention has been given to miniaturize the downstream functions of various microfluidic systems, leaving the sample introduction and preparation steps to more conventional, bulkier solutions. For point-of-care diagnostics in particular, it becomes crucial to be able to handle complex human samples in a miniaturized format.In this work, we report on a microsystem for on-chip sample preparation that is able to remove blood cells from whole blood. The hybrid system consists of a commercially available membrane filter incorporated into a poly(dimethylsiloxane) (PDMS) casted device. Membrane materials were evaluated on the bases of low nonspecific adsorption of free and protein-bound testosterone as analyte substance. The hybrid system including a hydrophilic polypropylene filter successfully removed blood cells from diluted human whole blood. Surface oxidation was sufficient to make the plasma filtrate flow through the membrane filter and the channel system by capillary force alone and thus no external pumping source was needed.

  5. A micro-system based on glass-nanoporous silicon for optical sensing of organic solvent vapor. (United States)

    Kim, Young-You; Kim, Han-Jung; Kim, Ho-Jong; Choi, Dae-Geun; Cheng, Horchhong


    We present a recent experimental study on the application of nanoporous silicon (np-Si) to an optical vapor sensor. We fabricated the micro-system based on a glass-nanoporous silicon layer on a p(+)-type silicon wafer. To check the selectivity and sensitivity of the np-Si layer to organic vapors, we prepared three types of np-Si layer samples--a single layer, distributed Bragg reflector (DBR) layer, and microcavity layer--and investigated its reflectance spectra upon exposure to different concentrations of various organic vapors. When the np-Si layer samples were exposed to the organic vapors, a red-shift occurred in the reflectance spectrum, and we determined that this red-shift can be attributed to the changes in the refractive index induced by the capillary condensation of the organic vapor within the pores of the np-Si layer. The np-Si layer samples showed excellent sensing ability to different types and concentrations of organic vapors. After removing the organic vapors, the reflectance spectrum immediately returned to its original state.

  6. Dielectrophoresis microsystem with integrated flow cytometers for on-line monitoring of sorting efficiency

    DEFF Research Database (Denmark)

    Wang, Zhenyu; Hansen, Ole; Petersen, Peter Kalsen


    Dielectrophoresis (DEP) and flow cytometry are powerful technologies and widely applied in microfluidic systems for handling and measuring cells and particles. Here, we present a novel microchip with a DEP selective filter integrated with two microchip flow cytometers (FCs) for on-line monitoring...... of cell sorting processes. On the microchip, the DEP filter is integrated in a microfluidic channel network to sort yeast cells by positive DER The two FCs detection windows are set upstream and downstream of the DEP filter. When a cell passes through the detection windows, the light scattered by the cell...

  7. The Intersection of CMOS Microsystems and Upconversion Nanoparticles for Luminescence Bioimaging and Bioassays

    Directory of Open Access Journals (Sweden)

    Liping Wei


    Full Text Available Organic fluorophores and quantum dots are ubiquitous as contrast agents for bio-imaging and as labels in bioassays to enable the detection of biological targets and processes. Upconversion nanoparticles (UCNPs offer a different set of opportunities as labels in bioassays and for bioimaging. UCNPs are excited at near-infrared (NIR wavelengths where biological molecules are optically transparent, and their luminesce in the visible and ultraviolet (UV wavelength range is suitable for detection using complementary metal-oxide-semiconductor (CMOS technology. These nanoparticles provide multiple sharp emission bands, long lifetimes, tunable emission, high photostability, and low cytotoxicity, which render them particularly useful for bio-imaging applications and multiplexed bioassays. This paper surveys several key concepts surrounding upconversion nanoparticles and the systems that detect and process the corresponding luminescence signals. The principle of photon upconversion, tuning of emission wavelengths, UCNP bioassays, and UCNP time-resolved techniques are described. Electronic readout systems for signal detection and processing suitable for UCNP luminescence using CMOS technology are discussed. This includes recent progress in miniaturized detectors, integrated spectral sensing, and high-precision time-domain circuits. Emphasis is placed on the physical attributes of UCNPs that map strongly to the technical features that CMOS devices excel in delivering, exploring the interoperability between the two technologies.

  8. On-chip electrochemical microsystems for measurements of copper and conductivity in artificial seawater. (United States)

    Herzog, Grégoire; Moujahid, Waleed; Twomey, Karen; Lyons, Conor; Ogurtsov, Vladimir I


    The fabrication and characterisation of microelectrochemical sensors for Cu(2+) and conductivity suitable for operation in the marine environment are presented. The impact of the designs on sensor performance and their adequacy to operate in real conditions are discussed. The sensors, tailored to voltammetric and impedimetric measurements, are fabricated on silicon using photolithographic and thin film deposition techniques. The impedimetric sensor is made of Pt interdigitated electrodes which are used for the measurement of conductivity. The voltammetric sensors are based on a three electrode electrochemical cell with on-chip Ag|AgCl reference and Pt counter and working electrodes, used for detection of copper by underpotential deposition-stripping voltammetry at microelectrode array. The sensors operated in the Cu(2+) concentrations ranging from 0.48 to 3.97 µM with a limit of detection of 0.115 μM. The impact of the temperature, the pH and the salinity of the artificial seawater on the sensitivity for Cu(2+) detection are also considered. Measurements of copper concentration and conductivity are validated using certified reference materials and standard solutions.

  9. Pulse-Reverse Electrodeposition and Micromachining of Graphene-Nickel Composite: An Efficient Strategy toward High-Performance Microsystem Application. (United States)

    Li, Jinhua; An, Zhonglie; Wang, Zhuqing; Toda, Masaya; Ono, Takahito


    Graphene reinforced nickel (Ni) is an intriguing nanocomposite with tremendous potential for microelectromechanical system (MEMS) applications by remedying mechanical drawbacks of the metal matrix for device optimization, though very few related works have been reported. In this paper, we developed a pulse-reverse electrodeposition method for synthesizing graphene-Ni (G-Ni) composite microcomponents with high content and homogeneously dispersed graphene filler. While the Vickers hardness is largely enhanced by 2.7-fold after adding graphene, the Young's modulus of composite under dynamic condition shows ∼1.4-fold increase based on the raised resonant frequency of a composite microcantilever array. For the first time, we also demonstrate the application of G-Ni composite in microsystems by fabricating a Si micromirror with the composite supporting beams as well as investigate the long-term stability of the mirror at resonant vibration. Compared with the pure Ni counterpart, the composite mirror shows an apparently lessened fluctuations of resonant frequency and scanning angle due to a suppressed plastic deformation even under the sustaining periodic loading. This can be ascribed to the reduced grain size of Ni matrix and dislocation hindering in the presence of graphene by taking into account the crystalline refinement strengthen mechanism. The rational discussions also imply that the strong interface and efficient load transfer between graphene layers and metal matrix play an important role for improving stiffness in composite. It is believed that a proper design of graphene-metal composite makes it a promising structural material candidate for advanced micromechanical devices.

  10. Shifted excitation resonance Raman difference spectroscopy using a microsystem light source at 488 nm (United States)

    Maiwald, M.; Sowoidnich, K.; Schmidt, H.; Sumpf, B.; Erbert, G.; Kronfeldt, H.-D.


    Experimental results in shifted excitation resonance Raman difference spectroscopy (SERRDS) at 488 nm will be presented. A novel compact diode laser system was used as excitation light source. The device is based on a distributed feedback (DFB) diode laser as a pump light source and a nonlinear frequency doubling using a periodically poled lithium niobate (PPLN) waveguide crystal. All elements including micro-optics are fixed on a micro-optical bench with a footprint of 25 mm × 5 mm. An easy temperature management of the DFB laser and the crystal was used for wavelength tuning. The second harmonic generation (SHG) provides an additional suppression of the spontaneous emission. Raman spectra of polystyrene demonstrate that no laser bandpass filter is needed for the Raman experiments. Resonance-Raman spectra of the restricted food colorant Tartrazine (FD&C Yellow 5, E 102) in distilled water excited at 488 nm demonstrate the suitability of this light source for SERRDS. A limit of detection (LOD) of 0.4 μmol.l-1 of E102 enables SERRDS at 488 nm for trace detection in e.g. food safety control as an appropriate contactless spectroscopic technique.

  11. Electroanalysis of metabolic flux from single cells in simple picoliter-volume microsystems. (United States)

    Yasukawa, Tomoyuki; Glidle, Andrew; Cooper, Jonathan M; Matsue, Tomokazu


    A picoliter-volume electrochemical analytical chamber has been developed for detecting the metabolic flux resulting from the stress responses of a single plant cell. Electrochemical cells, with volumes as small as 100 pL, were fabricated by controlled electrochemical dissolution of a gold wire sealed in glass (the back-etching of the metal realizing an ultralow-volume titer chamber). In the first instance, the electrode contained within the chamber was characterized by the microinjection of standard aliquots of either ascorbic acid or hydrogen peroxide. In all cases, experimental currents obtained correlated well with theoretical calculations. Subsequently, single plant cells were micromanipulated into the chambers and were exposed to amounts of the detergent SDS (which permeabilized the cell membrane and released the intracellular contents). The flux of metabolite released from a single cell was estimated by using electrochemical-linked assays based upon the enzymes catalase, ascorbate oxidase, and horseradish peroxidase (in each case), in the presence of a mediator. In so doing, we investigated the activity of the cellular protection mechanisms through the determination of peroxides, while the individual cell was "stressed". The technique was found to provide a reliable and reproducible method for making single-cell measurements, using fabrication procedures that are both simple and do not require photolithographic methods.

  12. A Wireless and Batteryless Microsystem with Implantable Grid Electrode/3-Dimensional Probe Array for ECoG and Extracellular Neural Recording in Rats

    Directory of Open Access Journals (Sweden)

    Chih-Wei Chang


    Full Text Available This paper presents the design and implementation of an integrated wireless microsystem platform that provides the possibility to support versatile implantable neural sensing devices in free laboratory rats. Inductive coupled coils with low dropout regulator design allows true long-term recording without limitation of battery capacity. A 16-channel analog front end chip located on the headstage is designed for high channel account neural signal conditioning with low current consumption and noise. Two types of implantable electrodes including grid electrode and 3D probe array are also presented for brain surface recording and 3D biopotential acquisition in the implanted target volume of tissue. The overall system consumes less than 20 mA with small form factor, 3.9 × 3.9 cm2 mainboard and 1.8 × 3.4 cm2 headstage, is packaged into a backpack for rats. Practical in vivo recordings including auditory response, brain resection tissue and PZT-induced seizures recording demonstrate the correct function of the proposed microsystem. Presented achievements addressed the aforementioned properties by combining MEMS neural sensors, low-power circuit designs and commercial chips into system-level integration.

  13. Microsystems Research in Japan (United States)


    tubes. A linked group of 10 micromachines is used. These self-assemble to form a chain. This includes a micro-reducer gear assembly and...and cell phones (e.g., for Samsung , etc.). Sales are approximately $30M/yr. Appendix B. Site Reports 92 The long-term scheme for silicon devices... s2 ±_ Figure B.15. Silicon capacitive micromachined sensors (total shipment over 8 million chips). In 1998, Omron�s MEMS division became a profit

  14. Etching in microsystem technology

    CERN Document Server

    Kohler, Michael


    Microcomponents and microdevices are increasingly finding application in everyday life. The specific functions of all modern microdevices depend strongly on the selection and combination of the materials used in their construction, i.e., the chemical and physical solid-state properties of these materials, and their treatment. The precise patterning of various materials, which is normally performed by lithographic etching processes, is a prerequisite for the fabrication of microdevices.The microtechnical etching of functional patterns is a multidisciplinary area, the basis for the etching p

  15. Energy harvesting for microsystems

    DEFF Research Database (Denmark)

    Xu, Ruichao

    The purpose of this project is to design and fabricate piezoelectric energy harvesters based on integration of Pb(ZrxTi1-x)O3 (PZT) thick film technology and silicon microtechnology. The fabrication processes are carried out in close collaboration with Meggitt Sensing Systems (MSS) who has...... the unique expertise to screen print piezoelectric thick film layers, thus all screen printing steps are done by MSS while the silicon micromachining is carried out at Danchip facility at DTU. The presented energy harvesters are all based on using piezoelectric thick film operating in the 31-mode to generate...... power when strained. Three archetypes of the numerous fabricated energy harvesters will be presented in detail, they represent three major milestones in this project. The first energy harvester archetype has an unimorph cantilever beam, which consists of a 20 µm silicon layer and 10-30 µm screen printed...

  16. Energy harvesting for microsystems

    Energy Technology Data Exchange (ETDEWEB)

    Ruichao Xu


    The purpose of this project is to design and fabricate piezoelectric energy harvesters based on integration of Pb(ZrxTi1-x)O3 (PZT) thick film technology and silicon microtechnology. The fabrication processes are carried out in close collaboration with Meggitt Sensing Systems (MSS) who has the unique expertise to screen print piezoelectric thick film layers, thus all screen printing steps are done by MSS while the silicon micromachining is carried out at Danchip facility at DTU. The presented energy harvesters are all based on using piezoelectric thick film operating in the 31-mode to generate power when strained. Three archetypes of the numerous fabricated energy harvesters will be presented in detail, they represent three major milestones in this project. The first energy harvester archetype has an unimorph cantilever beam, which consists of a 20 {mu}m silicon layer and 10-30 {mu}m screen printed PZT layer, anchored on a silicon frame at one end and attached to a silicon proof mass at the other. Electrodes will cover both side of the PZT layer, so the harvested energy can be collected electrically. The second archetype has a bimorph cantilever beam, which consists of two 15-35 {mu}m PZT layers, anchored on a silicon frame at the one end and attached to a silicon proof mass at the other. Electrodes are deposited below, between and above the two PZT layers. The root mean square (RMS) power output measured on this type of harvesters is as high as 37.1{mu}W at 1 g. The third archetype is similar to the first one, the screen printed PZT layer is replaced by a lead free piezoelectric material, (KxNa1-x)NbO3 (KNN). Some of the major challenges encountered during the development processes are bad adhesion, fragile structures and short circuiting through the PZT layer. All of which have being fully or partially solved in this project. The final energy harvesters are designed to be used in an energy harvester powered wireless sensing system. (Author)

  17. Sample pretretment in microsystems

    DEFF Research Database (Denmark)

    Perch-Nielsen, Ivan R.


    : Sample preparation → DNA amplification → DNA analysis. The overall goal of the project is integration of as many as possible of these steps. This thesis covers mainly pretreatment in a microchip. Some methods for sample pretreatment have been tested. Most conventional is fluorescence activated cell sort...

  18. Heat Pipe Integrated Microsystems

    Energy Technology Data Exchange (ETDEWEB)

    Gass, K.; Robertson, P.J.; Shul, R.; Tigges, C.


    The trend in commercial electronics packaging to deliver ever smaller component packaging has enabled the development of new highly integrated modules meeting the demands of the next generation nano satellites. At under ten kilograms, these nano satellites will require both a greater density electronics and a melding of satellite structure and function. Better techniques must be developed to remove the subsequent heat generated by the active components required to-meet future computing requirements. Integration of commercially available electronics must be achieved without the increased costs normally associated with current generation multi chip modules. In this paper we present a method of component integration that uses silicon heat pipe technology and advanced flexible laminate circuit board technology to achieve thermal control and satellite structure. The' electronics/heat pipe stack then becomes an integral component of the spacecraft structure. Thermal management on satellites has always been a problem. The shrinking size of electronics and voltage requirements and the accompanying reduction in power dissipation has helped the situation somewhat. Nevertheless, the demands for increased onboard processing power have resulted in an ever increasing power density within the satellite body. With the introduction of nano satellites, small satellites under ten kilograms and under 1000 cubic inches, the area available on which to place hot components for proper heat dissipation has dwindled dramatically. The resulting satellite has become nearly a solid mass of electronics with nowhere to dissipate heat to space. The silicon heat pipe is attached to an aluminum frame using a thermally conductive epoxy or solder preform. The frame serves three purposes. First, the aluminum frame provides a heat conduction path from the edge of the heat pipe to radiators on the surface of the satellite. Secondly, it serves as an attachment point for extended structures attached to the satellite such as solar panels, radiators, antenna and.telescopes (for communications or sensors). Finally, the packages make thermal contact to the surface of the silicon heat pipe through soft thermal pads. Electronic components can be placed on both sides of the flexible circuit interconnect. Silicon heat pipes have a number of advantages over heat pipe constructed from other materials. Silicon heat pipes offer the ability to put the heat pipe structure beneath the active components of a processed silicon wafer. This would be one way of efficiently cooling the heat generated by wafer scale integrated systems. Using this technique, all the functions of a satellite could be reduced to a few silicon wafers. The integration of the heat pipe and the electronics would further reduce the size and weight of the satellite.

  19. Introduction to microsystem design

    CERN Document Server

    Schomburg, Werner Karl


    This book systematically describes the design options for micro systems as well as the equations needed for calculating the behavior of their basic elements. The fundamental equations needed to calculate the effects and forces that are important in micro systems are also provided. Readers do not require previous knowledge of fabrication processes. This second edition of the volume is a thoroughly revised and extended update. The target audience primarily comprises experts in the field of micro systems and the book is also suitable for graduate engineering students. For quick reference, equations are presented in tables that can be found in an index at the end of the book.  .

  20. Ultrafast nanolaser device for detecting cancer in a single live cell.

    Energy Technology Data Exchange (ETDEWEB)

    Gourley, Paul Lee; McDonald, Anthony Eugene


    Emerging BioMicroNanotechnologies have the potential to provide accurate, realtime, high throughput screening of live tumor cells without invasive chemical reagents when coupled with ultrafast laser methods. These optically based methods are critical to advancing early detection, diagnosis, and treatment of disease. The first year goals of this project are to develop a laser-based imaging system integrated with an in- vitro, live-cell, micro-culture to study mammalian cells under controlled conditions. In the second year, the system will be used to elucidate the morphology and distribution of mitochondria in the normal cell respiration state and in the disease state for normal and disease states of the cell. In this work we designed and built an in-vitro, live-cell culture microsystem to study mammalian cells under controlled conditions of pH, temp, CO2, Ox, humidity, on engineered material surfaces. We demonstrated viability of cell culture in the microsystem by showing that cells retain healthy growth rates, exhibit normal morphology, and grow to confluence without blebbing or other adverse influences of the material surfaces. We also demonstrated the feasibility of integrating the culture microsystem with laser-imaging and performed nanolaser flow spectrocytometry to carry out analysis of the cells isolated mitochondria.

  1. Immuno-capture and in situ detection of Salmonella typhimurium on a novel microfluidic chip

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Renjie, E-mail: [College of Chemistry and Chemical Engineering, Chongqing University, No. 174, St. Shazheng, Shapingba District, Chongqing (China); Ni, Yanan, E-mail: [College of Chemistry and Chemical Engineering, Chongqing University, No. 174, St. Shazheng, Shapingba District, Chongqing (China); Xu, Yi, E-mail: [College of Chemistry and Chemical Engineering, Chongqing University, No. 174, St. Shazheng, Shapingba District, Chongqing (China); National Center for International Research of Micro/Nano-System and New Material Technology, No. 174, St. Shazhengjie, Shapingba District, Chongqing (China); Key Laboratory of Fundamental Science of Micro/Nano-Device and System Technology for National Defense, Chongqing (China); Jiang, Yan, E-mail: [College of Chemistry and Chemical Engineering, Chongqing University, No. 174, St. Shazheng, Shapingba District, Chongqing (China); Dong, Chunyan, E-mail: [College of Chemistry and Chemical Engineering, Chongqing University, No. 174, St. Shazheng, Shapingba District, Chongqing (China); Chuan, Na, E-mail: [College of Chemistry and Chemical Engineering, Chongqing University, No. 174, St. Shazheng, Shapingba District, Chongqing (China)


    Highlights: • A novel microfluidic chip and a LIF microsystem were designed and fabricated. • Salmonella typhimurium was captured and labeled by specific immuno-capture on chip. • CdSe/ZnS quantum dots-labeled bacteria were detected by in situ analysis using LIF microsystem. • The proposed method has potential application in practice. - Abstract: The new method presented in this article achieved the goal of capturing Salmonella typhimurium via immunoreaction and rapid in situ detection of the CdSe/ZnS quantum dots (QDs) labeled S. typhimurium by self-assembly light-emitting diode-induced fluorescence detection (LIF) microsystem on a specially designed multichannel microfluidic chip. CdSe/ZnS QDs were used as fluorescent markers improving detection sensitivity. The microfluidic chip developed in this study was composed of 12 sample channels, 3 mixing zones, and 6 immune reaction zones, which also acted as fluorescence detection zones. QDs–IgG–primary antibody complexes were generated by mixing CdSe/ZnS QDs conjugated secondary antibody (QDs–IgG) and S. typhimurium antibody (primary antibody) in mixing zones. Then, the complexes went into immune reaction zones to label previously captured S. typhimurium in the sandwich mode. The capture rate of S. typhimurium in each detection zone was up to 70%. The enriched QDs-labeled S. typhimurium was detected using a self-assembly LIF microsystem. A good linear relationship was obtained in the range from 3.7 × 10 to 3.7 × 10{sup 5} cfu mL{sup −1} using the equation I = 0.1739 log (C) − 0.1889 with R{sup 2} = 0.9907, and the detection limit was down to 37 cfu mL{sup −1}. The proposed method of online immunolabeling with QDs for in situ fluorescence detection on the designed multichannel microfluidic chip had been successfully used to detect S. typhimurium in pork sample, and it has shown potential advantages in practice.

  2. 系统工程方法论在微系统设计中的应用探索%Exploration of System Engineering Methodology in Micro-System Design

    Institute of Scientific and Technical Information of China (English)

    金长林; 郝继山; 罗海坤


    The history of the system engineering methodology is reviewed and the concept, characterization and features of the micro-system are summarized. Based on the Three Dimensional Morphology by A.D.Hall, the Four Dimensional Morphology for Micro-System (FDMMS) is presented for the first time. The benefits of the Model Based System Engineering (MBSE) approach over the Text Based System Engineering(TBSE) one have been emphasized and the classification of the micro-system model into descriptive model and analytic model for the practical engineering application is suggested. Finally, an example of micro-system design by the visual derivation, allocation and correlation of the requirements, functions, logics and physics of the system and unified data management of the descriptive model and analytical model is discussed in detail.%回顾了系统工程方法论的发展历史,总结了微系统的概念、内涵和特点。在系统工程方法论经典三维结构的基础上,提出了微系统四维结构体系。分析了“基于模型的系统工程”(MBSE)方法的优越性,从实际应用出发,提出把微系统模型分为描述模型和分析模型的建议。以一个实际例子,展示了微系统基于需求、功能、逻辑和物理的可视化分解、相互特性关联以及描述模型和分析模型的统一数据管理。

  3. Evaluation of the thermal and hydraulic performances of a very thin sintered copper flat heat pipe for 3D microsystem packages

    CERN Document Server

    Tzanova, S; Avenas, Y; Schaeffer, Ch


    The reported research work presents numerical studies validated by experimental results of a flat micro heat pipe with sintered copper wick structure. The objectives of this project are to produce and demonstrate the efficiency of the passive cooling technology (heat pipe) integrated in a very thin electronic substrate that is a part of a multifunctional 3-D electronic package. The enhanced technology is dedicated to the thermal management of high dissipative microsystems having heat densities of more than 10W/cm2. Future applications are envisaged in the avionics sector. In this research 2D numerical hydraulic model has been developed to investigate the performance of a very thin flat micro heat pipe with sintered copper wick structure, using water as a refrigerant. Finite difference method has been used to develop the model. The model has been used to determine the mass transfer and fluid flow in order to evaluate the limits of heat transport capacity as functions of the dimensions of the wick and the vapou...

  4. A 4 μW/Ch analog front-end module with moderate inversion and power-scalable sampling operation for 3-D neural microsystems. (United States)

    Al-Ashmouny, Khaled M; Chang, Sun-Il; Yoon, Euisik


    We report an analog front-end prototype designed in 0.25 μm CMOS process for hybrid integration into 3-D neural recording microsystems. For scaling towards massive parallel neural recording, the prototype has investigated some critical circuit challenges in power, area, interface, and modularity. We achieved extremely low power consumption of 4 μW/channel, optimized energy efficiency using moderate inversion in low-noise amplifiers (K of 5.98 × 10⁸ or NEF of 2.9), and minimized asynchronous interface (only 2 per 16 channels) for command and data capturing. We also implemented adaptable operations including programmable-gain amplification, power-scalable sampling (up to 50 kS/s/channel), wide configuration range (9-bit) for programmable gain and bandwidth, and 5-bit site selection capability (selecting 16 out of 128 sites). The implemented front-end module has achieved a reduction in noise-energy-area product by a factor of 5-25 times as compared to the state-of-the-art analog front-end approaches reported to date.

  5. Centrifugal loop-mediated isothermal amplification microdevice for rapid, multiplex and colorimetric foodborne pathogen detection. (United States)

    Oh, Seung Jun; Park, Byung Hyun; Jung, Jae Hwan; Choi, Goro; Lee, Doh C; Kim, Do Hyun; Seo, Tae Seok


    We present a centrifugal microfluidic device which enables multiplex foodborne pathogen identification by loop-mediated isothermal amplification (LAMP) and colorimetric detection using Eriochrome Black T (EBT). Five identical structures were designed in the centrifugal microfluidic system to perform the genetic analysis of 25 pathogen samples in a high-throughput manner. The sequential loading and aliquoting of the LAMP cocktail, the primer mixtures, and the DNA sample solutions were accomplished by the optimized zigzag-shaped microchannels and RPM control. We targeted three kinds of pathogenic bacteria (Escherichia coli O157:H7, Salmonella typhimurium and Vibrio parahaemolyticus) and detected the amplicons of the LAMP reaction by the EBT-mediated colorimetric method. For the limit-of-detection (LOD) test, we carried out the LAMP reaction on a chip with serially diluted DNA templates of E. coli O157:H7, and could observe the color change with 380 copies. The used primer sets in the LAMP reaction were specific only to the genomic DNA of E. coli O157:H7, enabling the on-chip selective, sensitive, and high-throughput pathogen identification with the naked eyes. The entire process was completed in 60min. Since the proposed microsystem does not require any bulky and expensive instrumentation for end-point detection, our microdevice would be adequate for point-of-care (POC) testing with high simplicity and high speed, providing an advanced genetic analysis microsystem for foodborne pathogen detection.

  6. Comparison of measurement methods for microsystem components: application to microstructures made by the deep x-ray lithography process (x-ray LIGA) (United States)

    Meyer, Pascal; Mäder, Olaf; Saile, Volker; Schulz, Joachim


    The LIGA (a German acronym for lithography, electroplating and molding) process using highly parallel x-rays permits the production of a microstructure with still unique characteristics: high aspect ratio, high accuracy, high perpendicularity and lower roughness of the side wall. From a marketing point of view, this qualitative description might suffice to attract users to the technology. Regarding widespread commercialization and standardization of x-ray LIGA products, our goal is to establish a rigorous dimensional metrology for which we need to understand and quantify uncertainty, which is the key to accuracy. We report on our metrological study using a coordinate measurement machine (CMM) equipped with a fibre probe (3D measurements) which will be compared to two versions of lateral top-view measurements (2D/surface measurements): an optical microscope provided with a micrometric table and a CMM with an image processing sensor; these two types of measurement methods being complementary. In fact, microsystem technology requires measurements to be performed with precision and accuracy within the range of 0.1 µm. In this paper, we present an analysis and a discussion of both types of measurement systems. The precision and reproducibility of the CMM (with fibre probe) during a two-year study will be exposed; a calibrated series part is being measured every time the machine is used. In this case, the CMM is used as a comparator. Its accuracy and the calibration of the ball diameter using an etalon (ceramic gage block) will be exposed. Furthermore, by taking into account the results obtained by the measurement system analysis (MSA), we will show the measurement's impact on the process by taking as an example the fabrication of mm gold gears for watch industry; a quantitative description of process reproducibility and of the influence of processing parameters influence will be possible in the future.

  7. The Fe-rich clay microsystems in basalt-komatiite lavas: importance of Fe-smectites for pre-biotic molecule catalysis during the Hadean eon. (United States)

    Meunier, Alain; Petit, Sabine; Cockell, Charles S; El Albani, Abderrazzak; Beaufort, Daniel


    During the Hadean to early Archean period (4.5-3.5 Ga), the surface of the Earth's crust was predominantly composed of basalt and komatiite lavas. The conditions imposed by the chemical composition of these rocks favoured the crystallization of Fe-Mg clays rather than that of Al-rich ones (montmorillonite). Fe-Mg clays were formed inside chemical microsystems through sea weathering or hydrothermal alteration, and for the most part, through post-magmatic processes. Indeed, at the end of the cooling stage, Fe-Mg clays precipitated directly from the residual liquid which concentrated in the voids remaining in the crystal framework of the mafic-ultramafic lavas. Nontronite-celadonite and chlorite-saponite covered all the solid surfaces (crystals, glass) and are associated with tiny pyroxene and apatite crystals forming the so-called "mesostasis". The mesostasis was scattered in the lava body as micro-settings tens of micrometres wide. Thus, every square metre of basalt or komatiite rocks was punctuated by myriads of clay-rich patches, each of them potentially behaving as a single chemical reactor which could concentrate the organics diluted in the ocean water. Considering the high catalytic potentiality of clays, and particularly those of the Fe-rich ones (electron exchangers), it is probable that large parts of the surface of the young Earth participated in the synthesis of prebiotic molecules during the Hadean to early Archean period through innumerable clay-rich micro-settings in the massive parts and the altered surfaces of komatiite and basaltic lavas. This leads us to suggest that Fe,Mg-clays should be preferred to Al-rich ones (montmorillonite) to conduct experiments for the synthesis and the polymerisation of prebiotic molecules.

  8. Array-type miniature interferometer as the core optical microsystem of an optical coherence tomography device for tissue inspection (United States)

    Passilly, Nicolas; Perrin, Stéphane; Lullin, Justine; Albero, Jorge; Bargiel, Sylwester; Froehly, Luc; Gorecki, Christophe; Krauter, Johann; Osten, Wolfgang; Wang, Wei-Shan; Wiemer, Maik


    Some of the critical limitations for widespread use in medical applications of optical devices, such as confocal or optical coherence tomography (OCT) systems, are related to their cost and large size. Indeed, although quite efficient systems are available on the market, e.g. in dermatology, they equip only a few hospitals and hence, are far from being used as an early detection tool, for instance in screening of patients for early detection of cancers. In this framework, the VIAMOS project aims at proposing a concept of miniaturized, batch-fabricated and lower-cost, OCT system dedicated to non-invasive skin inspection. In order to image a large skin area, the system is based on a full-field approach. Moreover, since it relies on micro-fabricated devices whose fields of view are limited, 16 small interferometers are arranged in a dense array to perform multi-channel simultaneous imaging. Gaps between each channel are then filled by scanning of the system followed by stitching. This approach allows imaging a large area without the need of large optics. It also avoids the use of very fast and often expensive laser sources, since instead of a single point detector, almost 250 thousands pixels are used simultaneously. The architecture is then based on an array of Mirau interferometers which are interesting for their vertical arrangement compatible with vertical assembly at the wafer-level. Each array is consequently a local part of a stack of seven wafers. This stack includes a glass lens doublet, an out-of-plane actuated micro-mirror for phase shifting, a spacer and a planar beam-splitter. Consequently, different materials, such as silicon and glass, are bonded together and well-aligned thanks to lithographic-based fabrication processes.

  9. Rapid Detection of Viable Microorganisms Based on a Plate Count Technique Using Arrayed Microelectrodes

    Directory of Open Access Journals (Sweden)

    Behraad Bahreyni


    Full Text Available Development of a miniaturized biosensor system that can be used for rapid detection and counting of microorganisms in food or water samples is described. The developed microsystem employs a highly sensitive impedimetric array of biosensors to monitor the growth of bacterial colonies that are dispersed across an agar growth medium. To use the system, a sample containing the bacteria is cultured above the agar layer. Using a multiplexing network, the electrical properties of the medium at different locations are continuously measured, recorded, and compared against a baseline signal. Variations of signals from different biosensors are used to reveal the presence of bacteria in the sample, as well as the locations of bacterial colonies across the biochip. This technique forms the basis for a label-free bacterial detection for rapid analysis of food samples, reducing the detection time by at least a factor of four compared to the current required incubation times of 24 to 72 hours for plate count techniques. The developed microsystem has the potential for miniaturization to a stage where it could be deployed for rapid analysis of food samples at commercial scale at laboratories, food processing facilities, and retailers.

  10. Design of an intelligent monitoring microsystem for dangerous/fragile cargo transportation%危险/易损货物运输监测智能微系统设计

    Institute of Scientific and Technical Information of China (English)

    娄文忠; 郭明儒; 祖绍鹏


    针对当前物流行业发展需求及现有监测系统的不足,提出了一种新的危险/易损货物运输监测智能微系统.该系统采用信息管理分系统、数据交换分系统和状态监测分系统3层构架,分别实现信息管理、数据传输和状态监测等功能,形成了全程、多态、实时的货物监测网络.系统采用模块化设计,通过独立的微型模块执行感知、处理、传输和存储等功能,并可根据需求进行模块裁剪.系统充分采用MEMS技术成果,实现了小型化、低功耗.试运行结果表明,该系统可以对危险/易损货物的运输实施有效监控,有助于提高物流的安全性和信息化.%An intelligent micro-system system is designed to monitor the transportation of dangerous/ fragile goods. It is necessary to monitor the transportation of special goods such as toxic substances or fireworks, but the correlation systems or devices have some deficiencies in the functional integrity and application scope. A novel monitoring system is designed to solve this problem. The new system consists of information management subsystem, communication subsystem and monitoring subsystem. The information management subsystem includes a server and several clients. It manages the data of the system and provides query functions. The communication subsystem is mainly used to convert the communication protocols. The monitoring subsystem is the key of the whole system which performs the functions of monitoring, data processing and safety assessing. The three parts work together to form a powerful net that could realize real-time monitoring. The monitoring subsystem, which adapts modularization design, can be divided into several function modules such as controlling module, detecting module, communicating module, etc. These modules are connected by internal bus, so the monitoring subsystem is scalable to meet the requirements of different customers. The MEMS technology and achievements

  11. Superoxide microsensor integrated into a Sensing Cell Culture Flask microsystem using direct oxidation for cell culture application. (United States)

    Flamm, H; Kieninger, J; Weltin, A; Urban, G A


    A new electrochemical sensor system for reliable and continuous detection of superoxide radical release from cell culture was developed utilizing direct oxidation of superoxide on polymer covered gold microelectrodes. Direct superoxide oxidation was demonstrated to provide robust measurement principle for sensitive and selective reactive oxygen species (ROS) quantification without the need for biocomponent supported conversion. Sensor performance was investigated by using artificial enzymatic superoxide production revealing a sensitivity of 2235AM(-1)m(-2). An electrode protection layer with molecular weight cut-off property from adsorbed linear branched polyethylenimine was successfully introduced for long term and selectivity improvement. Thin-film based sensor chip fabrication with implemented three-electrode setup and full integration into the technological platform Sensing Cell Culture Flask was described. Cell culturing directly on-chip and free radical release by phorbol-12-myristate-13-acetate (PMA) stimulation was demonstrated using T-47D human breast cancer carcinoma cell model. Transient extracellular superoxide production upon stimulation was successfully observed from amperometric monitoring. Signal inhibition from scavenging of extracellular superoxide by specific superoxide dismutase (SOD) showed the applicability for selective in vitro ROS determination. The results confirm the possibility of direct superoxide oxidation, with exclusion of the main interfering substances uric acid and hydrogen peroxide. This offers new insights into the development of reliable and robust ROS sensors.

  12. Detecting transforming growth factor-β release from liver cells using an aptasensor integrated with microfluidics. (United States)

    Matharu, Zimple; Patel, Dipali; Gao, Yandong; Haque, Amranul; Zhou, Qing; Revzin, Alexander


    We developed a cell-culture/biosensor platform consisting of aptamer-modified Au electrodes integrated with reconfigurable microfluidics for monitoring of transforming growth factor-beta 1 (TGF-β1), an important inflammatory and pro-fibrotic cytokine. Aptamers were thiolated, labeled with redox reporters, and self-assembled on gold surfaces. The biosensor was determined to be specific for TGF-β1 with an experimental detection limit of 1 ng/mL and linear range extending to 250 ng/mL. Upon determining figures of merit, aptasensor was miniaturized and integrated with human hepatic stellate cells inside microfluidic devices. Reconfigurable microfluidics were developed to ensure that seeding of "sticky" stromal cells did not foul the electrode and compromise sensor performance. This microsystem with integrated aptasensors was used to monitor TGF-β1 release from activated stellate cells over the course of 20 h. The electrochemical response went down upon infusing anti-TGF-β1 antibodies into the microfluidic devices containing activated stellate cells. To further validate aptasensor responses, stellate cells were stained for markers of activation (e.g., alpha smooth muscle actin) and were also tested for presence of TGF-β1 using enzyme linked immunosorbent assay (ELISA). Given the importance of TGF-β1 as a fibrogenic signal, a microsystem with integrated biosensors for local and continuous detection of TGF-β1 may prove to be an important tool to study fibrosis of the liver and other organs.

  13. A CMOS detection chip for amperometric sensors with chopper stabilized incremental ΔΣ ADC (United States)

    Min, Chen; Yuntao, Liu; Jingbo, Xiao; Jie, Chen


    This paper presents a low noise complimentary metal-oxide-semiconductor (CMOS) detection chip for amperometric electrochemical sensors. In order to effectively remove the input offset of the cascaded integrators and the low frequency noise in the modulator, a novel offset cancellation chopping scheme was proposed in the Incremental ΔΣ analog to digital converter (IADC). A novel low power potentiostat was employed in this chip to provide the biasing voltage for the sensor while mirroring the sensor current out for detection. The chip communicates with FPGA through standard built in I2C interface and SPI bus. Fabricated in 0.18-μm CMOS process, this chip detects current signal with high accuracy and high linearity. A prototype microsystem was produced to verify the detection chip performance with current input as well as micro-sensors. Project supported by the State Key Development Program for Basic Research of China (No. 2015CB352100).

  14. Solar Glitter -- Microsystems Enabled Photovoltaics (United States)

    Nielson, Gregory N.


    Many products have significantly benefitted from, or been enabled by, the ability to manufacture structures at an ever decreasing length scale. Obvious examples of this include integrated circuits, flat panel displays, micro-scale sensors, and LED lighting. These industries have benefited from length scale effects in terms of improved performance, reduced cost, or new functionality (or a combination of these). In a similar manner, we are working to take advantage of length scale effects that exist within solar photovoltaic (PV) systems. While this is a significant step away from traditional approaches to solar power systems, the benefits in terms of new functionality, improved performance, and reduced cost for solar power are compelling. We are exploring scale effects that result from the size of the solar cells within the system. We have developed unique cells of both crystalline silicon and III-V materials that are very thin (5-20 microns thick) and have very small lateral dimensions (on the order of hundreds of microns across). These cells minimize the amount of expensive semiconductor material required for the system, allow improved cell performance, and provide an expanded design space for both module and system concepts allowing optimized power output and reduced module and balance of system costs. Furthermore, the small size of the cells allows for unique high-efficiency, high-flexibility PV panels and new building-integrated PV options that are currently unavailable. These benefits provide a pathway for PV power to become cost competitive with grid power and allow unique power solutions independent of grid power.

  15. Synthesis of Biofluidic Microsystems (SYNBIOSYS) (United States)


    as a collection of interconnected mixing elements composed of microchannels , converging intersections and diverging intersections...reaction system. 58 FIGURE 41. The micro reactor is represented by a PFR network model. The calculation of reaction and convection is conducted in...82]. (b) Its system-level schematic. 65 FIGURE 46. Behavioral model structure for the electrokinetic reactor . At the inlet, the Fourier coefficients

  16. Fourier-transform optical microsystems (United States)

    Collins, S. D.; Smith, R. L.; Gonzalez, C.; Stewart, K. P.; Hagopian, J. G.; Sirota, J. M.


    The design, fabrication, and initial characterization of a miniature single-pass Fourier-transform spectrometer (FTS) that has an optical bench that measures 1 cm x 5 cm x 10 cm is presented. The FTS is predicated on the classic Michelson interferometer design with a moving mirror. Precision translation of the mirror is accomplished by microfabrication of dovetailed bearing surfaces along single-crystal planes in silicon. Although it is miniaturized, the FTS maintains a relatively high spectral resolution, 0.1 cm-1, with adequate optical throughput.

  17. Microsystem for signal processing applications (United States)

    Frankenstein, B.; Froehlich, K.-J.; Hentschel, D.; Reppe, G.


    Acoustic monitoring of technological processes requires methods that eliminate noise as much as possible. Sensor-near signal evaluation can contribute substantially. Frequently, a further necessity exists to integrate the measuring technique in the monitored structure. The solution described contains components for analog preprocessing of acoustic signals, their digitization, algorithms for data reduction, and digital communication. The core component is a digital signal processor (DSP). Digital signal processors perform the algorithms necessary for filtering, down sampling, FFT computation and correlation of spectral components particularly effective. A compact, sensor-near signal processing structure was realized. It meets the Match-X standard, which as specified by the German Association for Mechanical and Plant Engineering (VDMA) for development of micro-technical modules, which can be combined to applicaiton specific systems. The solution is based on AL2O3 ceramic components including different signal processing modules as ADC, as well as memory and power supply. An arbitrary waveform generator has been developed and combined with a power amplifier for piezoelectric transducers in a special module. A further module interfaces to these transducers. It contains a multi-channel preamplifier, some high-pass filters for analog signal processing and an ADC-driver. A Bluetooth communication chip for wireless data transmission and a DiscOnChip module are under construction. As a first application, the combustion behavior of safety-relevant contacts is monitored. A special waveform up to 5MHz is produced and sent to the monitored object. The resulting signal form is evaluated with special algorithms, which extract significant parameters of the signal, and transmitted via CAN-bus.

  18. Integration of Nanocomponents in Microsystems

    DEFF Research Database (Denmark)

    Kjelstrup-Hansen, Jakob


    beskadiges. Ved at forbinde fibrene med elektrodematerialer, der kan være ens såvel som forskellige, kan de elektriske egenskaber studeres, med henblik på at opnå strøm induceret lysudsendelse fra en enkelt nanofiber. På grundlag af studiet af forskellige metallers elektron- og hul-injicerende egenskaber...

  19. Reduced Dimensionality Lithium Niobate Microsystems

    Energy Technology Data Exchange (ETDEWEB)

    Eichenfield, Matt [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    The following report describes work performed under the LDRD program at Sandia National Laboratories October 2014 and September 2016. The work presented demonstrates the ability of Sandia Labs to develop state-of-the-art photonic devices based on thin film lithium niobate (LiNbO3 ). Section 1 provides an introduction to integrated LiNbO3 devices and motivation for developing thin film nonlinear optical systems. Section 2 describes the design, fabrication, and photonic performance of thin film optical microdisks fabricated from bulk LiNbO3 using a bulk implantation method developed at Sandia. Sections 3 and 4 describe the development of similar thin film LiNbO3 structures fabricated from LiNbO3 on insulator (LNOI) substrates and our demonstration of optical frequency conversion with state-of-the-art efficiency. Finally, Section 5 describes similar microdisk resonators fabricated from LNOI wafers with a buried metal layer, in which we demonstrate electro-optic modulation.

  20. Mechanics of Multifunctional Materials & Microsystems (United States)


    Thermal Energy Harvesting Flexible Battery of Graphene -CNT Hybrid > Integrated Solar Cells for MAV Wings < Multifunctional Mg-Li Alloy...Design of Reconfigurable Structures Active Cells for Multifunctional Structures Morphing CNT Microstructures Metamaterial Enhanced MEMS Acoustic... Metamaterials w Local Resonance Macroscale Meta-Materials Active Materials w Sensory & Adaptive Capabilities > Mechano-Responsive Polymer Systems

  1. Detection of a single magnetic microbead using a miniaturized silicon Hall sensor (United States)

    Besse, Pierre-A.; Boero, Giovanni; Demierre, Michel; Pott, Vincent; Popovic, Radivoje


    Using a highly sensitive silicon Hall sensor fabricated in a standard complementary metal-oxide-semiconductor (CMOS) technology, we detect a single magnetic microbead of 2.8 μm in diameter. The miniaturized sensor has an active area of 2.4×2.4 μm2, a sensitivity of 175 V/AT and a resistance of 8.5 kΩ. Two detection methods, both exploiting the superparamagnetic behavior of the bead, are experimentally tested and their performances are compared. This work opens the way to the fabrication of low cost microsystems for biochemical applications based on the use of dense arrays of silicon Hall sensors and CMOS electronics.

  2. Microfabricated Chemical Sensors for Aerospace Fire Detection Applications (United States)

    Hunter, Gary W.; Neudeck, Philip G.; Fralick, Gustave; Thomas, Valarie; Makel, D.; Liu, C. C.; Ward, B.; Wu, Q. H.


    The detection of fires on-board commercial aircraft is extremely important for safety reasons. Although dependable fire detection equipment presently exists within the cabin, detection of fire within the cargo hold has been less reliable and susceptible to false alarms. A second, independent method of fire detection to complement the conventional smoke detection techniques, such as the measurement of chemical species indicative of a fire, will help reduce false alarms and improve aircraft safety. Although many chemical species are indicative of a fire, two species of particular interest are CO and CO2. This paper discusses microfabricated chemical sensor development tailored to meet the needs of fire safety applications. This development is based on progress in three types of technology: 1) Micromachining and microfabrication (Microsystem) technology to fabricate miniaturized sensors. 2) The use of nanocrystalline materials to develop sensors with improved stability combined with higher sensitivity. 3) The development of high temperature semiconductors, especially silicon carbide. The individual sensor being developed and their level of maturity will be presented.

  3. 微型诊疗系统无线供能技术及其生物电磁效应研究%Wireless power transmission of microsystem and bioelectromagnetic effects

    Institute of Scientific and Technical Information of China (English)

    马官营; 颜国正; 王文兴


    Objective A wireless power transmission system based on inductive coupling was researched for power supplying of microsystem in intestinal tract.The bioelectromagnetic effects produced by the power transmission system were analyzed.Methods A time-varying electromagnetic field was produced by the transmitting coil rounded at abdomen.Inductive voltage provided energy for the in-body microsystem produced by a miniature coil.A high resolution realistic human model,including 56 kinds of tissues,was built in order to investigate the effects on human cased by the electromagnetic field.In this paper these tissues were identified by image segmentation technology.The bioelectromagnetic effects in the human model were calculated via numerical calculation method.Results The distribution of current density,magnetic intensity and specific energy absorption rate (SAR) were obtained.Whole-body average SAR at different frequencies was also achieved.Conclusions This research on bioelectromagnetic effects established a biology safety foundation for the application of this wireless power transmission technology.%目的 针对人体肠道内微型诊疗系统能量供应问题,研究了一种基于电磁耦合的无线能量传输系统,并对其产生的生物电磁效应进行分析.方法 围绕在人体腹部的发射线圈产生的交变磁场,体内微小线圈产生感应电动势为肠内诊疗系统提供电能.为了研究电磁场在人体组织产生的生物效应,本文首先采用图像分割技术对人体横断面图像进行组织识别,建立了包含56种组织的高精度三维真实人体数字化模型,然后通过数值计算的方法研究了能量传输系统的生物电磁效应.结果 获得电流密度、比吸收率、磁场强度在人体的分布,以及不同频率下全身平均比吸收率.结论 生物电磁效应的研究为无线供能技术在人体肠道诊疗系统的应用奠定了生物安全性基础.

  4. Highly sensitive polymer-based cantilever-sensors for DNA detection

    Energy Technology Data Exchange (ETDEWEB)

    Calleja, M. [Biosensors Group, Nacional Center of Microelectronics (CNM-CSIC), Isaac Newton 8, Tres Cantos, E-28760 Madrid (Spain) and Mikroelektronics Centret, Technical University of Denmark, 345E, DK-2800, Lyngby (Denmark)]. E-mail:; Nordstroem, M. [Mikroelektronics Centret, Technical University of Denmark, 345E, DK-2800, Lyngby (Denmark); Alvarez, M. [Biosensors Group, Nacional Center of Microelectronics (CNM-CSIC), Isaac Newton 8, Tres Cantos, E-28760 Madrid (Spain); Tamayo, J. [Biosensors Group, Nacional Center of Microelectronics (CNM-CSIC), Isaac Newton 8, Tres Cantos, E-28760 Madrid (Spain); Lechuga, L.M. [Biosensors Group, Nacional Center of Microelectronics (CNM-CSIC), Isaac Newton 8, Tres Cantos, E-28760 Madrid (Spain); Boisen, A. [Mikroelektronics Centret, Technical University of Denmark, 345E, DK-2800, Lyngby (Denmark)


    We present a technology for the fabrication of cantilever arrays aimed to develop an integrated biosensor microsystem. The fabrication process is based on spin coating of the photosensitive polymer and near-ultraviolet exposure. Arrays of up to 33 microcantilevers are fabricated in the novel polymer material SU-8. The low Young's modulus of the polymer, 40 times lower than that of silicon, enables to improve the sensitivity of the sensor device for target detection. The mechanical properties of SU-8 cantilevers, such as spring constant, resonant frequency and quality factor are characterized as a function of the dimensions and the medium. The devices have been tested for measurement of the adsorption of single stranded DNA and subsequent interstitial adsorption of lateral spacer molecules. We demonstrate that sensitivity is enhanced by a factor of six compared to that of commercial silicon nitride cantilevers.

  5. A novel capillary electrophoresis microchip with amperometric detection using a Prussian blue-modified indium tin oxide electrode (United States)

    Kim, Ju-Ho; Kang, C. J.; Kim, Yong-Sang


    A novel approach to construct a disposable capillary electrophoresis microchip is proposed. The electrocatalytic oxidation of dopamine at a Prussian blue (PB)-modified indium tin oxide (ITO) electrode was described and the amperometric detection of dopamine was then investigated. The PB film on ITO electrode was electrodeposited using FeCl3 and K3Fe(CN)6 mixed solution. Our results indicated that PB film was uniform, smooth, and defect-free. The CE-chip has been tested successfully by detecting dopamine and catechol within a very short time of around 80 sec using an electric field of 60 V/cm. The results also showed that dopamine and catechol mixtures were separated efficiently and rapidly. The microsystems gave a very good reproducibility for peak height and separation time. This microchip is cost effective and adequate for a disposable sensor.

  6. Microchip-Based Organophosphorus Detection Using Bienzyme Bioelectrocatalysis (United States)

    Han, Yong Duk; Jeong, Chi Yong; Lee, Jun Hee; Lee, Dae-Sik; Yoon, Hyun C.


    We have developed a microsystem for the detection of organophosphorus (OP) compounds using acetylcholine esterase (AchE) and choline oxidase (ChOx) bienzyme bioelectrocatalysis. Because AchE is irreversibly inhibited by OP pesticides, the change in AchE activity with OP treatment can be traced to determine OP concentration. Polymer-associated ChOx immobilization on the working electrode surface and magnetic microparticle (MP)-assisted AchE deposition methods were employed to create an AchE-ChOx bienzyme-modified biosensing system. ChOx was immobilized on the micropatterned electrodes using poly(L-lysine), glutaraldehyde, and amine-rich interfacial surface. AchE was immobilized on the MP surface via Schiff's base formation, and the enzyme-modified MPs were deposited on the working electrode using a magnet under the microfluidic channel. The bioelectrocatalytic reaction between AchE-ChOx bienzyme cascade and the ferrocenyl electron shuttle was successfully used to detect OP with the developed microchip. This provides a self-contained and relatively easy method for OP detection. It requires minimal time and a small sample size, and has potential analytic applications in pesticides and chemical warfare agents.

  7. Academic Emotions of Adolescents:Based on the View of Family Microsystem%青少年学业情绪:基于家庭微系统视角的探索

    Institute of Scientific and Technical Information of China (English)

    俞国良; 朱琳; 董妍


    This study elaborates the role of family in academic emotions from the view of microsys-tem.Based on the perspectives of the ecosystem theories and control value theory,the paper analyzes plenty of researches on the influence of family and parents in academic emotions.We find that family characteristics (socioeconomic status and parents’emotionality),parent child interaction (parent child relationship and parenting styles)and child characteristics factors (cognitive ability,personality treats and self cognition)all can affect adolescents’academic emotions,and academic emotions are af-fected by family characteristics via parent child interactive and child characteristics factors.Based on the above findings,we propound a hypothetical dynamic model about family microsystem impact aca-demic emotions,and propose the future research direction from a comprehensive perspective.%本文从微系统的视角阐述了家庭环境因素对青少年学业情绪的作用。以生态系统理论和学业情绪的控制价值理论为依托,在分析大量研究文献的基础上,作者发现家庭特征(家庭社会经济地位、父母情绪特点等)、亲子互动(亲子关系、教养方式等)以及青少年自身因素(认知能力、人格特征和自我认知等)都会显著影响青少年的学业情绪,且家庭特征往往通过亲子互动状况及青少年自身因素对学业情绪发挥作用。基于此,作者提出了家庭微系统影响青少年学业情绪的理论模型,并以此模型为基础对将来研究方向进行了全面展望。

  8. A new method of micro-system and high-throughput determination of glucoamylase activity by Colorimetry%小体系高通量比色测定糖化酶活力新方法

    Institute of Scientific and Technical Information of China (English)

    刘洋; 唐芳荣; 相宏宇; 朱洪亮; 谢秋宏


    In this study, we reported a new assay method that a micro-system determined the activity of glucoamylase by dinitrosalicylic acid (DNS) reaction. In 96-well plates, glucose concentration and optical density (OD) values showed linear relationship at 540nm, and the linear correlation coefficient (r) values was 0.9996. The sample recovery experiment described that the recovery range and the relative standard deviation (RSD) was 98.5%~ 103.2% and 1.8%, respectively. The precision analysis to confirm the method is accurate and reliable. To compared with national standard method, the differences in rates of glucoamylase activity assay was less than 0.5%. The method is rapid, accurate and high-throughput on determination of glucoamylase activity, and will become an important method on quality control of commodity glucoamylase and screening of glucoamylase producing strain.%本研究建立了一种小体系结合96孔板比色测定糖化酶活力的新方法.经实验证明,在96孔板内,波长540nm处,葡萄糖浓度与光密度(OD)值有很好的线性关系,其线性相关系数r值达到0.9996;通过加样回收实验发现,其回收率为98.5%~103.2%,相对标准差为1.8%;通过精密度分析实验发现该方法测量样品的精密度优于国标法及普通DNS法,其测定的结果与现行国家标准测定糖化酶方法所得到的结果差异率小于0.5%.本研究建立的方法不仅准确、可靠,而且实现了小体系、高通量快速比色测定,为糖化酶工业检测及糖化酶生产菌株的高通量筛选奠定了重要方法基础.

  9. Stacking technology for a space constrained microsystem

    DEFF Research Database (Denmark)

    Heschel, Matthias; Kuhmann, Jochen Friedrich; Bouwstra, Siebe;


    In this paper we present a stacking technology for an integrated packaging of an intelligent transducer which is formed by a micromachined silicon transducer and an integrated circuit chip. Transducer and circuitry are stacked on top of each other with an intermediate chip in between. The bonding...... of the transducer and the intermediate chip is done by flip chip solder bump bonding. The bonding between the above two-layer stack and the circuit chip is done by conductive adhesive bonding combined with gold studs. We demonstrate the stacking technologies on passive test chips rather than real devices and report...... on technological details...

  10. Conformable M3 Microsystems for Aerodynamic Control (United States)


    we have fabricated sensors, actuators, and electronics all on the same chip. Control: • A CMOS control circuit has been designed and sent to MOSIS ...macro aerodynamic devices. (3) After the chip from MOSIS is fabricated, it will be tested to confirm that it works as designed. (4) The process and...identify the separation point from the outputs of shear stress sensors and drive the corresponding actuators. The layout has been sent to MOSIS for

  11. Biodriven microsystem for treatment of hydrocephalus (United States)

    Joswig, Jurgen; Oswald, Jens; Seifert, Steffen


    A microvalve system made of silicon for use in hydrocephalus therapy is presented, which will provide an excellent intracranial pressure stabilization. Design and processing are described. Testing results (in vitro) are presented.

  12. Applications of Integrated Polymer Waveguides in Microsystems

    DEFF Research Database (Denmark)

    Wang, Zhenyu


    Denne PhD afhandling fokuserer på anvendelsen af integrerede polymerer bølgeledere for real-time optisk detektion i mikrofabikerede analysesystemer. Ved at anvende en ny fabrikationsteknologi til plane bølgeledere blev SU-8 bølgeledere integreret i mikrochip flow cytometer, mikrochip DEP-flow...... cytometer, og real-time mikrochip PCR. På grund af sine gode optiske egenskaber blev den negative epoxy fotoresist SU-8 valgt til at fremstille integreret polymer optik (bølgeledere, linser, og fiber-til-bølgeledere koblere) til optisk detektion. Det mikrofluide netværk blev også fremstillet i SU-8. Den...

  13. Biomechanical microsystems design, processing and applications

    CERN Document Server

    Ostasevicius, Vytautas; Palevicius, Arvydas; Gaidys, Rimvydas; Jurenas, Vytautas


    This book presents the most important aspects of analysis of dynamical processes taking place on the human body surface. It provides an overview of the major devices that act as a prevention measure to boost a person‘s motivation for physical activity. A short overview of the most popular MEMS sensors for biomedical applications is given. The development and validation of a multi-level computational model that combines mathematical models of an accelerometer and reduced human body surface tissue is presented. Subsequently, results of finite element analysis are used together with experimental data to evaluate rheological properties of not only human skin but skeletal joints as well. Methodology of development of MOEMS displacement-pressure sensor and adaptation for real-time biological information monitoring, namely “ex vivo” and “in vitro” blood pulse type analysis, is described. Fundamental and conciliatory investigations, achieved knowledge and scientific experience about biologically adaptive mu...

  14. Wireless power transfer for medical microsystems

    CERN Document Server

    Sun, Tianjia; Wang, Zhihua


    This book equips readers with tools for computer architecture of high performance, low power, and high reliability memory hierarchy in computer systems based on emerging memory technologies, such as STTRAM, PCM, FBDRAM, etc.  The techniques described offer advantages of high density, near-zero static power, and immunity to soft errors, which have the potential of overcoming the “memory wall.”  The authors discuss memory design from various perspectives: emerging memory technologies are employed in the memory hierarchy with novel architecture modification;  hybrid memory structure is introduced to leverage advantages from multiple memory technologies; an analytical model named “Moguls” is introduced to explore quantitatively the optimization design of a memory hierarchy; finally, the vulnerability of the CMPs to radiation-based soft errors is improved by replacing different levels of on-chip memory with STT-RAMs.  ·         Provides a holistic study of using emerging memory technologies in...

  15. Electrohydrodynamics and dielectrophoresis in microsystems: scaling laws

    Energy Technology Data Exchange (ETDEWEB)

    Castellanos, A [Dpto. Electronica y Electromagnetismo, Facultad de FIsica, Universidad de Sevilla, Reina Mercedes s/n, 41012 Sevilla (Spain); Ramos, A [Dpto. Electronica y Electromagnetismo, Facultad de FIsica, Universidad de Sevilla, Reina Mercedes s/n, 41012 Sevilla (Spain); Gonzalez, A [Dpto. Electronica y Electromagnetismo, Facultad de FIsica, Universidad de Sevilla, Reina Mercedes s/n, 41012 Sevilla (Spain); Green, N G [Bioelectronics Research Centre, Dept. Electronics and Electrical Engineering, University of Glasgow, Oakfield Avenue, Glasgow G12 8LT (United Kingdom); Morgan, H [Bioelectronics Research Centre, Dept. Electronics and Electrical Engineering, University of Glasgow, Oakfield Avenue, Glasgow G12 8LT (United Kingdom)


    The movement and behaviour of particles suspended in aqueous solutions subjected to non-uniform ac electric fields is examined. The ac electric fields induce movement of polarizable particles, a phenomenon known as dielectrophoresis. The high strength electric fields that are often used in separation systems can give rise to fluid motion, which in turn results in a viscous drag on the particle. The electric field generates heat, leading to volume forces in the liquid. Gradients in conductivity and permittivity give rise to electrothermal forces and gradients in mass density to buoyancy. In addition, non-uniform ac electric fields produce forces on the induced charges in the diffuse double layer on the electrodes. This causes a steady fluid motion termed ac electro-osmosis. The effects of Brownian motion are also discussed in this context. The orders of magnitude of the various forces experienced by a particle in a model microelectrode system are estimated. The results are discussed in relation to experiments and the relative influence of each type of force is described.

  16. Flexible neuroendoscopy with laser and microsystem technique (United States)

    Huewel, Norbert M.; Urban, Volker; Perneczky, A.


    The use of flexible neuroendoscopic techniques in neurosurgical procedures is routinely performed in the spinal canal and in the intracranial subdural space. Treated entities are syringomyelia, tumors with concomitant syrinxes in spinal cord, cystic legions in the subdural and subarachnoid space in the spinal canal as myelomeningoceles.

  17. Biochip microsystem for bioinformatics recognition and analysis (United States)

    Lue, Jaw-Chyng (Inventor); Fang, Wai-Chi (Inventor)


    A system with applications in pattern recognition, or classification, of DNA assay samples. Because DNA reference and sample material in wells of an assay may be caused to fluoresce depending upon dye added to the material, the resulting light may be imaged onto an embodiment comprising an array of photodetectors and an adaptive neural network, with applications to DNA analysis. Other embodiments are described and claimed.

  18. Optical microsystems based on a nanomaterial technology

    Energy Technology Data Exchange (ETDEWEB)

    De Stefano, L [National Council of Research-Institute for Microelectronic and Microsystems-Department of Naples, Via P Castellino 111, 80131 Naples (Italy); Rotiroti, L [National Council of Research-Institute for Microelectronic and Microsystems-Department of Naples, Via P Castellino 111, 80131 Naples (Italy); Rea, I [National Council of Research-Institute for Microelectronic and Microsystems-Department of Naples, Via P Castellino 111, 80131 Naples (Italy); Iodice, M [National Council of Research-Institute for Microelectronic and Microsystems-Department of Naples, Via P Castellino 111, 80131 Naples (Italy); Rendina, I [National Council of Research-Institute for Microelectronic and Microsystems-Department of Naples, Via P Castellino 111, 80131 Naples (Italy)


    In this work, we present an optical sensor for quantitative determination of the alcohol content in hydro-alcohol mixtures, realized by using porous silicon (PSi) nanotechnology. The device is an oxidized PSi micro-cavity (PSMC) constituted by a Fabry-Perot layer between two distributed Bragg reflectors. Due to the capillary condensation, a red shift of the PSMC reflectivity spectrum is observed on exposure to vapour mixtures. The phenomenon is completely reversible. Moreover, to reduce the analysis time, we have designed the integration of the sensor in a thermally controlled lab-on-chip, by merging PSi and anodic bonding technologies. Numerical calculations have been performed to study the thermal behaviour of the integrated device.

  19. CMOS post-processing for monolithic microsystems

    NARCIS (Netherlands)

    Schmitz, Jurriaan


    The semiconductor industry is adjusting focus towards the so-called “More than Moore” innovation. By this is meant that microchip progress may not (or not only) follow from Moore’s Law and its resulting dimensional scaling, but can also come from the addition of new components, new layers and new fu

  20. Electrospun Nanopaper and its Applications to Microsystems (United States)

    Lingaiah, Shivalingappa; Shivakumar, Kunigal; Sadler, Robert


    A new method of preparing Nylon-66 nanopaper using electrospun nonwoven nanofiber and fiber fusing is presented. The fusing temperature for Nylon-66 nanofiber was found to be 190°C. Both carbon and glass fiber reinforced nanopapers were prepared. The unreinforced Nylon-66 nanopaper of areal density 4.5 g/m2 had a modulus and strength of 681 MPa and 92.8 MPa, respectively, while the unfused nanopaper had 430 MPa and 59.3 MPa, respectively. This increase was attributed to fusing of randomly oriented fibers. Several types of insect wings, namely FlyTech dragonfly and Deadalus flight system wings, were fabricated and tested for their flyability. Vibration test was conducted to measure the wing stiffness by matching the measured first natural frequency to the stiffness.

  1. Integrated microsystems packaging approach with LCP (United States)

    Jaynes, Paul; Shacklette, Lawrence W.


    Within the government communication market there is an increasing push to further miniaturize systems with the use of chip-scale packages, flip-chip bonding, and other advances over traditional packaging techniques. Harris' approach to miniaturization includes these traditional packaging advances, but goes beyond this level of miniaturization by combining the functional and structural elements of a system, thus creating a Multi-Functional Structural Circuit (MFSC). An emerging high-frequency, near hermetic, thermoplastic electronic substrate material, Liquid Crystal Polymer (LCP), is the material that will enable the combination of the electronic circuit and the physical structure of the system. The first embodiment of this vision for Harris is the development of a battlefield acoustic sensor module. This paper will introduce LCP and its advantages for MFSC, present an example of the work that Harris has performed, and speak to LCP MFSCs' potential benefits to miniature communications modules and sensor platforms.

  2. A microsystems enabled field desorption source.

    Energy Technology Data Exchange (ETDEWEB)

    Hertz, Kristin L.; Resnick, Paul James; Schwoebel, Paul R. (University of New Mexico, Albuquerque, NM); Holland, Christopher E. (SRI International, Menlo Park, CA); Chichester, David L. (Idaho National Laboratory, Idaho Falls, ID)


    Technologies that have been developed for microelectromechanical systems (MEMS) have been applied to the fabrication of field desorption arrays. These techniques include the use of thick films for enhanced dielectric stand-off, as well as an integrated gate electrode. The increased complexity of MEMS fabrication provides enhanced design flexibility over traditional methods.

  3. Integration of bulk piezoelectric materials into microsystems (United States)

    Aktakka, Ethem Erkan

    Bulk piezoelectric ceramics, compared to deposited piezoelectric thin-films, provide greater electromechanical coupling and charge capacity, which are highly desirable in many MEMS applications. In this thesis, a technology platform is developed for wafer-level integration of bulk piezoelectric substrates on silicon, with a final film thickness of 5-100microm. The characterized processes include reliable low-temperature (200°C) AuIn diffusion bonding and parylene bonding of bulk-PZT on silicon, wafer-level lapping of bulk-PZT with high-uniformity (+/-0.5microm), and low-damage micro-machining of PZT films via dicing-saw patterning, laser ablation, and wet-etching. Preservation of ferroelectric and piezoelectric properties is confirmed with hysteresis and piezo-response measurements. The introduced technology offers higher material quality and unique advantages in fabrication flexibility over existing piezoelectric film deposition methods. In order to confirm the preserved bulk properties in the final film, diaphragm and cantilever beam actuators operating in the transverse-mode are designed, fabricated and tested. The diaphragm structure and electrode shapes/sizes are optimized for maximum deflection through finite-element simulations. During tests of fabricated devices, greater than 12microm PP displacement is obtained by actuation of a 1mm2 diaphragm at 111kHz with management IC, which incorporates a supply-independent bias circuitry, an active diode for low-dropout rectification, a bias-flip system for higher efficiency, and a trickle battery charger. The overall system does not require a pre-charged battery, and has power consumption of sleep-mode (simulated). Under lg vibration at 155Hz, a 70mF ultra-capacitor is charged from OV to 1.85V in 50 minutes.

  4. Reliability of industrial packaging for microsystems

    DEFF Research Database (Denmark)

    Reus, Roger De; Christensen, Carsten; Weichel, Steen


    Packaging concepts for silicon-based micromachined sensors exposed to harsh environments are explored. By exposing the sensors directly to the media and applying protection at the wafer level the packaging and assembly will be simplified as compared to conventional methods of fabrication. Protect...

  5. Magneto-mechanical trapping systems for biological target detection

    KAUST Repository

    Li, Fuquan


    We demonstrate a magnetic microsystem capable of detecting nucleic acids via the size difference between bare magnetic beads and bead compounds. The bead compounds are formed through linking nonmagnetic beads and magnetic beads by the target nucleic acids. The system comprises a tunnel magneto-resistive (TMR) sensor, a trapping well, and a bead-concentrator. The TMR sensor detects the stray field of magnetic beads inside the trapping well, while the sensor output depends on the number of beads. The size of the bead compounds is larger than that of bare magnetic beads, and fewer magnetic beads are required to fill the trapping well. The bead-concentrator, in turn, is capable of filling the trap in a controlled fashion and so to shorten the assay time. The bead-concentrator includes conducting loops surrounding the trapping well and a conducting line underneath. The central conducting line serves to attract magnetic beads in the trapping well and provides a magnetic field to magnetize them so to make them detectable by the TMR sensor. This system excels by its simplicity in that the DNA is incubated with magnetic and nonmagnetic beads, and the solution is then applied to the chip and analyzed in a single step. In current experiments, a signal-to-noise ratio of 40.3 dB was obtained for a solution containing 20.8 nM of DNA. The sensitivity and applicability of this method can be controlled by the size or concentration of the nonmagnetic bead, or by the dimension of the trapping well.

  6. Hydrogel-Framed Nanofiber Matrix Integrated with a Microfluidic Device for Fluorescence Detection of Matrix Metalloproteinases-9. (United States)

    Han, Sang Won; Koh, Won-Gun


    Matrix metalloproteinases (MMPs) play a pivotal role in regulating the composition of the extracellular matrix and have a critical role in vascular disease, cancer progression, and bone disorders. This paper describes the design and fabrication of a microdevice as a new platform for highly sensitive MMP-9 detection. In this sensing platform, fluorescein isocyanate (FITC)-labeled MMP-9 specific peptides were covalently immobilized on an electrospun nanofiber matrix to utilize an enzymatic cleavage strategy. Prior to peptide immobilization, the nanofiber matrix was incorporated into hydrogel micropatterns for easy size control and handling of the nanofiber matrix. The resultant hydrogel-framed nanofiber matrix immobilizing the peptides was inserted into microfluidic devices consisting of reaction chambers and detection zones. The immobilized peptides were reacted with the MMP-9-containing solution in a reaction chamber, which resulted in the cleavage of the FITC-containing peptide fragments and subsequently generated fluorescent flow at the detection zone. As higher concentrations of the MMP-9 solution were introduced or larger peptide-immobilizing nanofiber areas were used, more peptides were cleaved, and a stronger fluorescence signal was observed. Due to the huge surface area of the nanofiber and small dimensions of the microsystem, a faster response time (30 min) and lower detection limit (10 pM) could be achieved in this study. The hydrogel-framed nanofiber matrix is disposable and can be replaced with new ones immobilizing either the same or different biomolecules for various bioassays, while the microfluidic system can be continuously reused.

  7. One-chip electronic detection of DNA hybridization using precision impedance-based CMOS array sensor. (United States)

    Lee, Kang-Ho; Lee, Jeong-Oen; Sohn, Mi-Jin; Lee, Byunghun; Choi, Suk-Hwan; Kim, Sang Kyu; Yoon, Jun-Bo; Cho, Gyu-Hyeong


    This paper describes a label-free and fully electronic detection method of DNA hybridization, which is achieved through the use of a 16×8 microarray sensor in conjunction with a new type of impedance spectroscopy constructed with standard complementary metal-oxide-semiconductor (CMOS) technology. The impedance-based method is based on changes in the reactive capacitance and the charge-transfer resistance after hybridization with complementary DNA targets. In previously published label-free techniques, the measured capacitance presented unstable capacitive properties due to the parallel resistance that is not infinite and can cause a leakage by discharging the charge on the capacitor. This paper presents an impedance extraction method that uses excitation by triangular wave voltage, which enables a reliable measurement of both C and R producing a highly sensitive sensor with a stable operation independent of external variables. The system was fabricated in an industrial 0.35-μm 4-metal 2-poly CMOS process, integrating working electrodes and readout electronics into one chip. The integrated readout, which uses a parasitic insensitive integrator, achieves an enlarged detection range and improved noise performance. The maximum average relative variations of C and R are 31.5% and 68.6%, respectively, after hybridization with a 1 μM target DNA. The proposed sensor allows quantitative evaluation of the molecule densities on the chip with distinguishable variation in the impedance. This fully electronic microsystem has great potential for use with bioanalytical tools and point-of-care diagnosis.

  8. Antithyroid drug detection using an enzyme cascade blocking in a nanoparticle-based lab-on-a-chip system. (United States)

    Kurbanoglu, Sevinc; Mayorga-Martinez, Carmen C; Medina-Sánchez, Mariana; Rivas, Lourdes; Ozkan, Sibel A; Merkoçi, Arben


    A methimazole (MT) biosensor based on a nanocomposite of magnetic nanoparticles (MNPs) functionalized with iridium oxide nanoparticles (IrOx NPs) and tyrosinase (Tyr) immobilized onto screen printed electrode (SPE) by using a permanent magnet is presented. This system is evaluated in batch mode via chelating copper at the active site of tyrosinase and in flow mode by thioquinone formation. The MT detection in flow mode is achieved using a hybrid polydimethylsiloxane/polyester amperometric lab-on-a-chip (LOC) microsystem with an integrated SPE. Both systems are very sensitive with low limit of detection (LOD): 0.006 μM and 0.004 μM for batch and flow modes, respectively. Nevertheless, the flow mode has advantages such as its reusability, automation, low sample volume (6 μL), and fast response (20 s). Optimization and validation parameters such as enzyme-substrate amount, flow rate, inhibition conditions, repeatability and reproducibility of the biosensor have been performed. The proposed methods have been applied in MT detection in spiked human serum and pharmaceutical dosage forms.

  9. Supernova detection

    Energy Technology Data Exchange (ETDEWEB)

    Nakahata, Masayuki [Kamioka Observatory, Institute for Cosmic Ray research, University of Tokyo, Higashi-Mozumi, Kamioka-cho, Hida-shi, Gifu, Japan, 506-1205 (Japan)], E-mail:


    The detection of supernova neutrinos is reviewed, focusing on the current status of experiments to detect supernova burst neutrinos and supernova relic neutrinos. The capabilities of each detector currently operating and in development are assessed and the likely neutrino yield for a future supernova is estimated. It is expected that much more information will be obtained if a supernova burst were to occur in our Galaxy than was obtained for supernova SN1987A. The detection of supernova relic neutrinos is considered and it is concluded that a large volume detector with a neutron tagging technique is necessary.

  10. Arteriosclerosis Detection (United States)


    The Veterans Administration Hospital used computer image-processing techniques to detect arteriosclerosis. Originally developed by Goddard Space Flight Center engineers to enhance spacecraft pictures, this device replaced the previous testing for this disease which was extremely painful and time consuming. With this instrument, computer detected edges are shown along with an estimate of location of pre-arteriosclerosis vessel wall. The difference between the two represents the relative amount of disease in the blood vessel. Instrumentation will be expanded again in 1976 to analyze the coronary arteries and the blood vessels of the retina.

  11. Fingerprint detection

    Energy Technology Data Exchange (ETDEWEB)

    Saunders, G.C.


    This patent describes a method for detection and visualization of latent fingerprints. It comprises contacting a substrate containing a latent print thereon the a colloidal metal composition at a pH from about 2.5 to about 4.0 for time sufficient to allow reaction of the colloidal metal composition with the latent print; and, preserving or recording the observable print.

  12. Detection device (United States)

    Smith, J.E.


    The present invention is directed to a detection device comprising: (1) an entrance chamber; (2) a central chamber; and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

  13. Animal Detectives (United States)

    Mulvey, Bridget; Warnock, Carly


    During a two-week inquiry-based 5E learning cycle unit, children made observations and inferences to guide their explorations of animal traits and habitats (Bybee 2014). The children became "animal detectives" by studying a live-feed webcam and digital images of wolves in their natural habitat, reading books and online sources about…

  14. An integrated rotary microfluidic system with DNA extraction, loop-mediated isothermal amplification, and lateral flow strip based detection for point-of-care pathogen diagnostics. (United States)

    Park, Byung Hyun; Oh, Seung Jun; Jung, Jae Hwan; Choi, Goro; Seo, Ji Hyun; Kim, Do Hyun; Lee, Eun Yeol; Seo, Tae Seok


    Point-of-care (POC) molecular diagnostics plays a pivotal role for the prevention and treatment of infectious diseases. In spite of recent advancement in microfluidic based POC devices, there are still rooms for development to realize rapid, automatic and cost-effective sample-to-result genetic analysis. In this study, we propose an integrated rotary microfluidic system that is capable of performing glass microbead based DNA extraction, loop mediated isothermal amplification (LAMP), and colorimetric lateral flow strip based detection in a sequential manner with an optimized microfluidic design and a rotational speed control. Rotation direction-dependent coriolis force and siphon valving structures enable us to perform the fluidic control and metering, and the use of the lateral flow strip as a detection method renders all the analytical processes for nucleic acid test simplified and integrated without the need of expensive instruments or human intervention. As a proof of concept for point-of-care DNA diagnostics, we identified the food-borne bacterial pathogen which was contaminated in water or milk. Not only monoplex Salmonella Typhimurium but also multiplex Salmonella Typhimurium and Vibrio parahaemolyticus were analysed on the integrated rotary genetic analysis microsystem with a limit of detection of 50 CFU in 80min. In addition, three multiple samples were simultaneously analysed on a single device. The sample-to-result capability of the proposed microdevice provides great usefulness in the fields of clinical diagnostics, food safety and environment monitoring.

  15. A scalable engineering approach to improve performance of a miniaturized optical detection system for in vitro point-of-care testing (United States)

    Robbins, Hannah; Hu, Sijung; Liu, Changqing


    The demand for rapid screening technologies, to be used outside of a traditional healthcare setting, has been vastly expanding. This is requiring a new engineering platform for faster and cost effective techniques to be easily adopted through forward-thinking manufacturing procedures, i.e., advanced miniaturisation and heterogeneous integration of high performance microfluidics based point-of-care testing (POCT) systems. Although there has been a considerable amount of research into POCT systems, there exist tremendous challenges and bottlenecks in the design and manufacturing in order to reach a clinical acceptability of sensitivity and selectivity, as well as smart microsystems for healthcare. The project aims to research how to enable scalable production of such complex systems through 1) advanced miniaturisation of a physical layout and opto-electronic component allocation through an optimal design; and 2) heterogeneous integration of multiplexed fluorescence detection (MFD) for in vitro POCT. Verification is being arranged through experimental testing with a series of dilutions of commonly used fluorescence dye, i.e. Cy5. Iterative procedures will be engaged until satisfaction of the detection limit, of Cy5 dye, 1.209x10-10 M. The research creates a new avenue of rapid screening POCT manufacturing solutions with a particular view on high performance and multifunctional detection systems not only in POCT, but also life sciences and environmental applications.

  16. Edge Detection, (United States)


    PROJECT. T ASK0 Artificial Inteligence Laboratory AREA It WORK UNIT NUMBERS V 545 Technology Square ( Cambridge, HA 02139 I I* CONTOOL1LIN@4OFFICE NAME...ARD-A1t62 62 EDGE DETECTION(U) NASSACNUSETTS INST OF TECH CAMBRIDGE 1/1 ARTIFICIAL INTELLIGENCE LAB E C HILDRETH SEP 85 AI-M-8 N99SI4-8S-C-6595...used to carry out this analysis. cce~iO a N) ’.~" D LI’BL. P p ------------ Sj. t i MASSACHUSETTS INSTITUTE OF TECHNOLOGY i ARTIFICIAL INTELLIGENCE

  17. Smoke detection

    Energy Technology Data Exchange (ETDEWEB)

    Warmack, Robert J. Bruce; Wolf, Dennis A.; Frank, Steven Shane


    Various apparatus and methods for smoke detection are disclosed. In one embodiment, a method of training a classifier for a smoke detector comprises inputting sensor data from a plurality of tests into a processor. The sensor data is processed to generate derived signal data corresponding to the test data for respective tests. The derived signal data is assigned into categories comprising at least one fire group and at least one non-fire group. Linear discriminant analysis (LDA) training is performed by the processor. The derived signal data and the assigned categories for the derived signal data are inputs to the LDA training. The output of the LDA training is stored in a computer readable medium, such as in a smoke detector that uses LDA to determine, based on the training, whether present conditions indicate the existence of a fire.

  18. On-line ion exchange preconcentration in a sequential injection lab-on-valve microsystem incorporating a renewable column with ETAAS for the trace-level determination of bismuth in urine and river sediment

    DEFF Research Database (Denmark)

    Wang, Jianhua; Hansen, Elo Harald


    A sequential injection system for on-line ion-exchange separation and preconcentration of trace-level amounts of metal ions with ensuing detection by electrothermal atomic absorption spectrometry (ETAAS) is described. Based on the use of a renewable microcolumn incorporated within an integrated l.......3% for the determination of 2.0 mug/l Bi (n = 7). The procedure was validated by determination of bismuth in a certified reference material CRM 320 (river sediment), and by bismuth spike recoveries in two human urine samples....

  19. Development and Application of Analytical Microsystem for Environmental Pollutants Monitoring%微全分析系统在环境污染物检测中的研究与应用

    Institute of Scientific and Technical Information of China (English)

    张晓凤; 徐溢; 马亮波


    In the researching field of environmental monitoring, high effective detecting methodology of environmental pollutants had been attracted significant interest all over the world. Micro total analysis systems (μTAS)provided favorable technology platform and new technique ways for this purpose. The progress of the detection of the small molecules environmental pollutants, for example, organic pollutants including organophosphate,nitroaromatic compounds, phenols, carbamate pesticides, and aromatic amines; inorganic pollutants including various anions and metal cation; air pollutants including nitrogen oxides, SO2, H2S, formaldehyde, and ammonia etc with μTAS during the last few years was reviewed in this paper. Corresponding research situation and technology progress of quick and efficient separation detection on microfluidic chips were discussed. In addition, the problems in environmental pollutants monitoring with μTAS were put forward and the future of μTAS in environmental pollutants monitoring were prospected.%环境污染物的高效检测是分析领域关注的焦点,微全分析系统(μTAS)为现代环境监测提供了良好的技术平台和新的技术途径.本文综述了近年来μTAS在小分子环境样品检测和分析方面的研究进展,重点针对有机磷类、含硝基化合物、酚类、氨基甲酸酯类、芳香胺等有机污染物,各类阴离子和金属阳离子等无机污染物,氮氧化物、二氧化硫、硫化氢、甲醛和氨等气体污染物,探讨和综述了微流控芯片分析技术对其进行快速高效分离检测的相关研究现状和技术进展,进而指出了μTAS目前用于环境样品分析时存在的问题,展望了μTAS在环境污染物样品检测和分析方面的发展趋势.

  20. Demonstration of submersible high-throughput microfluidic immunosensors for underwater explosives detection. (United States)

    Adams, André A; Charles, Paul T; Deschamps, Jeffrey R; Kusterbeck, Anne W


    Significant security threats posed by highly energetic nitroaromatic compounds in aquatic environments and the demilitarization and pending cleanup of areas previously used for munitions manufacture and storage represent a challenge for less expensive, faster, and more sensitive systems capable of analyzing groundwater and seawater samples for trace levels of explosive materials. Presented here is an inexpensive high throughput microfluidic immunosensor (HTMI) platform intended for the rapid, highly selective quantitation of nitroaromatic compounds in the field. Immunoaffinity and fluorescence detection schemes were implemented in tandem on a novel microfluidic device containing 39 parallel microchannels that were 500 μm tall, 250 μm wide, and 2.54 cm long with covalently tethered antibodies that was engineered for high-throughput high-volume sample processing. The devices were produced via a combination of high precision micromilling and hot embossing. Mass transfer limitations were found in conventional microsystems and were minimized due to higher surface area to volume ratios that exceeded those possessed by conventional microdevices and capillaries. Until now, these assays were limited to maximum total volume flow rates of ~1 mL/min due in part to kinetics and high head pressures of single microchannels. In the design demonstrated here, highly parallelized microchannels afforded up to a 100-fold increase in total volume flow rate while maintaining favorable kinetic constraints for efficient antigen-antibody interaction. The assay employed total volume throughput of up to 6 mL/min while yielding signal-to-noise ratios of >15 in all cases. In addition to samples being processed up to 60 times faster than in conventional displacement-based immunoassays, the current system was capable of quantitating 0.01 ng/mL TNT samples without implementing offline preconcentration, thereby, demonstrating the ability to improve sensitivity by as much as 2 orders of magnitude

  1. Highly Sensitive Polymer-based Cantilever-sensors for DNA Detection

    DEFF Research Database (Denmark)

    Gomez, Montserrat; Nordström, Maria; Alvarez, M.


    We present a technology for the fabrication of cantilever arrays aimed to develop an integrated biosensor microsystem. The fabrication process is based on spin coating of the photosensitive polymer and near-ultraviolet exposure. Arrays of up to 33 microcantilevers are fabricated in the novel poly...

  2. Evaluating Edge Detection through Boundary Detection

    Directory of Open Access Journals (Sweden)

    Wang Song


    Full Text Available Edge detection has been widely used in computer vision and image processing. However, the performance evaluation of the edge-detection results is still a challenging problem. A major dilemma in edge-detection evaluation is the difficulty to balance the objectivity and generality: a general-purpose edge-detection evaluation independent of specific applications is usually not well defined, while an evaluation on a specific application has weak generality. Aiming at addressing this dilemma, this paper presents new evaluation methodology and a framework in which edge detection is evaluated through boundary detection, that is, the likelihood of retrieving the full object boundaries from this edge-detection output. Such a likelihood, we believe, reflects the performance of edge detection in many applications since boundary detection is the direct and natural goal of edge detection. In this framework, we use the newly developed ratio-contour algorithm to group the detected edges into closed boundaries. We also collect a large data set ( of real images with unambiguous ground-truth boundaries for evaluation. Five edge detectors (Sobel, LoG, Canny, Rothwell, and Edison are evaluated in this paper and we find that the current edge-detection performance still has scope for improvement by choosing appropriate detectors and detector parameters.

  3. Miniaturized tools and devices for bioanalytical applications: an overview

    DEFF Research Database (Denmark)

    Chudy, M.; Grabowska, I.; Ciosek, P.


    This article presents an overview of various miniaturized devices and technologies developed by our group. Innovative, fast and cheap procedures for the fabrication of laboratory microsystems based on commercially available materials are reported and compared with well-established microfabricatio...... optic detectors, potentiometric sensors platforms, microreactors and capillary electrophoresis (CE) microchips as well as integrated microsystems e. g. double detection microanalytical systems, devices for studying enzymatic reactions and a microsystem for cell culture and lysis....

  4. Detection of Terahertz Radiation

    DEFF Research Database (Denmark)


    The present invention relates to a system for detecting terahertz radiation, a camera device, and a method for detecting terahertz radiation.......The present invention relates to a system for detecting terahertz radiation, a camera device, and a method for detecting terahertz radiation....

  5. On Edge Detection, (United States)


    T. 0. "On boundary detection." A. I. Memo 183, MIT, 1980. Hildreth, E. C. "Implementation of a theory of edge detection ." A. /. Memo 579, MIT, 1980...Detection." IEEE Trans. PAMI, 6, 678-680, 1983. Marr, 0. C. and Hildreth, E. C, " Theory of edge detection ." Proc. R. Soc. Lond. B, 207, 187-217, 1980. Marr

  6. Bio-Mechanical Interfaces for Cell-Based Microsystems (United States)


    cytoskeleton. SCPFM overcomes these limitations by utilizing novel polymer Nano- Electro-Mechanical-Systems ( NEMS ) force sensors . SCPFM is a fully...integrated, monolithic instrument that combines the near-single molecule force measurement capabilities of ( NEMS ) based force sensors with integrated...developed novel polymer NEMS devices that contain integrated metallic piezoresistive (strain coupled) force sensors . Polymer (SU-8, polyimide or

  7. Ultraviolet transparent silicon oxynitride waveguides for biochemical microsystems

    DEFF Research Database (Denmark)

    Mogensen, Klaus Bo; Friis, Peter; Hübner, Jörg


    The UV wavelength region is of great interest in absorption spectroscopy, which is employed for chemical analysis, since many organic compounds absorb in only this region. Germanium-doped silica, which is often preferred as the waveguide core material in optical devices for telecommunication......, cannot accommodate guidance below 400 nm, owing to the presence of UV-absorbing centers. We show that silicon oxynitride (SiOxNy) waveguides exhibit very good UV performance. The propagation loss for 24-mum-wide SiOxNy waveguides was found to be similar to1.0 dB/cm in the wavelength range 220-550 nm...

  8. Noncontact surface thermometry for microsystems: LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Abel, Mark (Georgia Institute of Technology, Atlanta, GA); Beecham, Thomas (Georgia Institute of Technology, Atlanta, GA); Graham, Samuel (Georgia Institute of Technology, Atlanta, GA); Kearney, Sean Patrick; Serrano, Justin Raymond; Phinney, Leslie Mary


    We describe a Laboratory Directed Research and Development (LDRD) effort to develop and apply laser-based thermometry diagnostics for obtaining spatially resolved temperature maps on working microelectromechanical systems (MEMS). The goal of the effort was to cultivate diagnostic approaches that could adequately resolve the extremely fine MEMS device features, required no modifications to MEMS device design, and which did not perturb the delicate operation of these extremely small devices. Two optical diagnostics were used in this study: microscale Raman spectroscopy and microscale thermoreflectance. Both methods use a low-energy, nonperturbing probe laser beam, whose arbitrary wavelength can be selected for a diffraction-limited focus that meets the need for micron-scale spatial resolution. Raman is exploited most frequently, as this technique provides a simple and unambiguous measure of the absolute device temperature for most any MEMS semiconductor or insulator material under steady state operation. Temperatures are obtained from the spectral position and width of readily isolated peaks in the measured Raman spectra with a maximum uncertainty near {+-}10 K and a spatial resolution of about 1 micron. Application of the Raman technique is demonstrated for V-shaped and flexure-style polycrystalline silicon electrothermal actuators, and for a GaN high-electron-mobility transistor. The potential of the Raman technique for simultaneous measurement of temperature and in-plane stress in silicon MEMS is also demonstrated and future Raman-variant diagnostics for ultra spatio-temporal resolution probing are discussed. Microscale thermoreflectance has been developed as a complement for the primary Raman diagnostic. Thermoreflectance exploits the small-but-measurable temperature dependence of surface optical reflectivity for diagnostic purposes. The temperature-dependent reflectance behavior of bulk silicon, SUMMiT-V polycrystalline silicon films and metal surfaces is presented. The results for bulk silicon are applied to silicon-on-insulator (SOI) fabricated actuators, where measured temperatures with a maximum uncertainty near {+-}9 K, and 0.75-micron inplane spatial resolution, are achieved for the reflectance-based measurements. Reflectance-based temperatures are found to be in good agreement with Raman-measured temperatures from the same device.

  9. Nanothermite-Based Microsystem for Drug Delivery and Cell Transfection (United States)


    the atrium or ventricle with Papain (Worthington, Lakewood, NJ) according to the manufacturer’s protocol. Briefly, Papain was activated for 30 min...a Papain solution in a Hanks Balanced Salt (HBBS) solution of Ca2+ and Mg2+ free for 5 to10 minutes. Then the Papain was inactivated by the addition

  10. Innovative Microsystems: Novel Nanostructures to Capture Circulating Breast Cancer Cells (United States)


    agitated by the auto shake function 5 seconds before each read. These data are then interpreted with a Michaelis - Menten model of the HRP enzyme kinetics ...Amplex Red) and fluorescent product (Resorufin) in a given micro-plate well as a function of time t; Vmax and KM are the standard Michaelis - Menten ...Molecular Probes). The fluorescence signal, generated by the action of the HRP immobilized on the chiclets, is then read in kinetic mode with excitation

  11. Magnetic forces produced by rectangular permanent magnets in static microsystems. (United States)

    Gassner, Anne-Laure; Abonnenc, Mélanie; Chen, Hong-Xu; Morandini, Jacques; Josserand, Jacques; Rossier, Joel S; Busnel, Jean-Marc; Girault, Hubert H


    Finite element numerical simulations were carried out in 2D geometries to map the magnetic field and force distribution produced by rectangular permanent magnets as a function of their size and position with respect to a microchannel. A single magnet, two magnets placed in attraction and in repulsion have been considered. The goal of this work is to show where magnetic beads are preferentially captured in a microchannel. These simulations were qualitatively corroborated, in one geometrical case, by microscopic visualizations of magnetic bead plug formation in a capillary. The results show that the number of plugs is configuration dependent with: in attraction, one plug in the middle of the magnets; in repulsion, two plugs near the edges of the magnets; and with a single magnet, a plug close to the center of the magnet. The geometry of the magnets (h and l are the height and length of the magnets respectively) and their relative spacing s has a significant impact on the magnetic flux density. Its value inside a magnet increases with the h/l ratio. Consequently, bar magnets produce larger and more uniform values than flat magnets. The l/s ratio also influences the magnetic force value in the microchannel, both increasing concomitantly for all the configurations. In addition, a zero force zone in the middle appears in the attraction configuration as the l/s ratio increases, while with a single magnet, the number of maxima and minima goes from one to two, producing two focusing zones instead of only one.

  12. Injection moulding and selective metallisation technologies for polymer Microsystems

    DEFF Research Database (Denmark)

    Tenchine, L.; Gout, S.; Dessors, S.;


    The present paper describes how developing and optimizing high-throughput integrated technologies for theproduction of miniaturised multi-material and multi-functional components at industrial scale. Based on 2 industrialdemonstrators (a band diplexer and a micro aeraulic device), the paper shows...

  13. Microfluidic pressure amplifier circuits and electrostatic gates for pneumatic microsystems

    Energy Technology Data Exchange (ETDEWEB)

    Tice, Joshua D.; Bassett, Thomas A.; Desai, Amit V.; Apblett, Christopher A.; Kenis, Paul J. A.


    An electrostatic actuator is provide that can include a fluidic line, a first electrode, and a second electrode such that a gate chamber portion of the fluidic line is sandwiched between the first electrode and the second electrode. The electrostatic actuator can also include a pressure-balancing channel in fluid communication with the gate chamber portion where the first electrode is sandwiched between the pressure-balancing channel and the gate chamber portion. A pneumatic valve system is provided which includes an electrostatic gate and a fluidic channel fluidly separate from a fluidic control line. A pneumatic valve portion of the fluidic control line can be positioned relative to a portion of the fluidic channel such that expansion of the pneumatic valve portion restricts fluid flow through the fluidic channel. Methods of using an electrostatic actuator and a pneumatic valve system are also provided.

  14. Digital holography and its application for microsystems inspection

    Institute of Scientific and Technical Information of China (English)


    A large number of applications in the before mentioned sense is reported in the literature. In this paper a special remark will be given to the application of 3D deformation measurements using only one illumination direction for the recording of the two holograms in the reference and the loaded state, and only one observation direction for the reconstruction.

  15. Circuitry for a Wireless Microsystem for Neural Recording Microprobes (United States)


    Fig. 2. The receiver coil, D1 and C1 form a half-rectifier. The opamp works in the negative feedback loop to adjust the current through the pass...problem associated with NMOS pass device, a simple voltage-doubling block, made up of C2 and D2, is used to provide higher supply voltage to the opamp ...ensure that the two integrator outputs mostly vary within the normal output range of the practical opamp . The circuit is shown in Fig. 7. Fig. 6

  16. Large Scale Integration of Carbon Nanotubes in Microsystems

    DEFF Research Database (Denmark)

    Gjerde, Kjetil


    nøjere. Det blir vist at nanorør skove kan bruges som non-stick overflader hvilket gør manipulering av mikro og nanostrukturer meget lettere. Objekter som latex microkugler og organiske nanofibre kan manipuleres, efter først at have været spredt ud på nanorør skoven. I tredje del beskrives konstruktion...

  17. Microsystem technology for high-flux hydrogen separation membranes

    NARCIS (Netherlands)

    Gielens, F.C.; Tong, H.D.; Rijn, van C.J.M.; Vorstman, M.A.G.; Keurentjes, J.T.F.


    The application of thin hydrogen-selective membranes suffers from the occurrence of pinholes and a significant resistance to mass transfer in the porous support. To overcome these problems, Pd, Pd/Ag and Pd–Ta–Pd membranes with a thickness between 0.5 and 1.2 μm have been deposited on a dense and sm

  18. Wafer scale integration of catalyst dots into nonplanar microsystems

    DEFF Research Database (Denmark)

    Gjerde, Kjetil; Kjelstrup-Hansen, Jakob; Gammelgaard, Lauge;


    In order to successfully integrate bottom-up fabricated nanostructures such as carbon nanotubes or silicon, germanium, or III-V nanowires into microelectromechanical systems on a wafer scale, reliable ways of integrating catalyst dots are needed. Here, four methods for integrating sub-100-nm...... diameter nickel catalyst dots on a wafer scale are presented and compared. Three of the methods are based on a p-Si layer utilized as an in situ mask, an encapsulating layer, and a sacrificial window mask, respectively. All methods enable precise positioning of nickel catalyst dots at the end...

  19. Interconnect schemes for stretchable array-type microsystems

    NARCIS (Netherlands)

    Sosin, S.


    Flexible systems can be found in many fields such as automotive electronics, computers and peripherals (hard drives, image scanners, ink-jet print-head cables), aerospace, consumer electronics (mobile phones, cameras etc), medical (hearing aids, pacemakers) and many others. Further reduction in size

  20. Sol-gel layers for ceramic microsystems application (United States)

    Czok, Mateusz; Golonka, Leszek


    This paper describes research on sol-gel solutions preparation process. Utilize of a sol-gel layers in the LTCC technology for reduction of surface roughness and influence on the ceramics properties is examined and described. The influence of sol-gel layer on possible sedimentation of dyes or biological substances in channels, mixers or chambers of ceramic microfluidic structures was investigated. Moreover, properties of sol-gel coated surfaces have been precisely examined and described. Finally, positive results of conducted experiments made it possible to design and manufacture a simple microfluidic ceramic structure, with embedded protective layer of sol-gel, for fluorescence measurements.

  1. Robust hermetic packaging techniques for MEMS integrated microsystems.

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Junseok (University of Michigan); Stark, Brian H. (University of Michigan); Kuo, Andrew (University of Michigan); Oliver, Andrew David; Najafi, Khalil (University of Michigan)


    This work is the result of a Sandia National Laboratories LDRD funded fellowship at the University of Michigan. Although, guidance and suggestions were offered by Sandia, the work contained here is primarily the work of Brian H. Stark, and his advisor, Professor Khalil Najafi. Junseok Chae, Andrew Kuo, and their coworkers at the University of Michigan helped to record some of the data. The following is an abstract of their work. We have developed a vacuum packaging technology using a thick nickel film to seal MEMS structures at the wafer level. The package is fabricated in a three-mask process by electroplating a 40 micro-meter thick nickel film over an 8 micro-meter sacrificial photoresist that is removed prior to package sealing. Implementation of electrical feedthroughs in this process requires no planarization. The large release channel enables an 800x800 micro-meter package to be released in less than three hours. Several mechanisms, based upon localized melting and lead/tin solder bumping, for sealing the release channel have been investigated. We have also developed Pirani gauges, integrated with this package, which can be used to establish the hermeticity of the different sealing technologies. They have measured a sealing pressure of approximately 1.5 Torr. Our work differs from previous Pirani gauges in that we utilize a novel doubly anchored structure that stiffens the structural membrane while not substantially degrading performance in order to measure fine leak rates.

  2. Microsystem reliability: Polymer adhesive and coating materials for packaging

    DEFF Research Database (Denmark)

    Janting, Jakob

    aggressive surroundings. Focus is on how the adhesion of protective polymer adhesives and coatings can be characterized theoretically and practically and optimized regarding intrinsic properties, the surroundings and their mutual influences. The main conclusion is that the mutual influences make a system...


    Directory of Open Access Journals (Sweden)



    Full Text Available La micromanipulación de partículas biológicas es una operación frecuente en medicina y microbiología, y se ha dedicado una gran cantidad de trabajo para desarrollar técnicas de manipulación mas rápidas, baratas y eficientes. En este sentido, la tecnología de microsistemas juega un papel importante ya que se puede utilizar para fabricar manipuladores de micropartículas. En este articulo se describe el diseño y fabricación de un microsistema para la manipulación de objetos biológicos, basado en el efecto dielectroforetico. También se discute la selección de la alternativa tecnológica mas adecuada dentro de las disponibles. El diseño propuesto, es un microsistema completo que incluye interfases eléctrica, óptica y fluidica, y se desarrolló empleando oro y platino como metales para los electrodos, micro mecanizado del silicio y técnicas de fotocurado de resinas fotosensibles. De la misma forma se describe la estructura de los microelectrodos desarrollados al igual que el circuito integrado resultante.

  4. Outlier detection using autoencoders

    CERN Document Server

    Lyudchik, Olga


    Outlier detection is a crucial part of any data analysis applications. The goal of outlier detection is to separate a core of regular observations from some polluting ones, called “outliers”. We propose an outlier detection method using deep autoencoder. In our research the invented method was applied to detect outlier points in the MNIST dataset of handwriting digits. The experimental results show that the proposed method has a potential to be used for anomaly detection.

  5. Revolution in Detection Affairs

    Energy Technology Data Exchange (ETDEWEB)

    Stern W.


    The detection of nuclear or radioactive materials for homeland or national security purposes is inherently difficult. This is one reason detection efforts must be seen as just one part of an overall nuclear defense strategy which includes, inter alia, material security, detection, interdiction, consequence management and recovery. Nevertheless, one could argue that there has been a revolution in detection affairs in the past several decades as the innovative application of new technology has changed the character and conduct of detection operations. This revolution will likely be most effectively reinforced in the coming decades with the networking of detectors and innovative application of anomaly detection algorithms.

  6. Interior intrusion detection systems

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, J.R.; Matter, J.C. (Sandia National Labs., Albuquerque, NM (United States)); Dry, B. (BE, Inc., Barnwell, SC (United States))


    The purpose of this NUREG is to present technical information that should be useful to NRC licensees in designing interior intrusion detection systems. Interior intrusion sensors are discussed according to their primary application: boundary-penetration detection, volumetric detection, and point protection. Information necessary for implementation of an effective interior intrusion detection system is presented, including principles of operation, performance characteristics and guidelines for design, procurement, installation, testing, and maintenance. A glossary of sensor data terms is included. 36 figs., 6 tabs.

  7. Enzyme detection by microfluidics

    DEFF Research Database (Denmark)


    Microfluidic-implemented methods of detecting an enzyme, in particular a DNA-modifying enzyme, are provided, as well as methods for detecting a cell, or a microorganism expressing said enzyme. The enzyme is detected by providing a nucleic acid substrate, which is specifically targeted...... by that enzyme...

  8. Autonomous Forest Fire Detection

    NARCIS (Netherlands)

    Breejen, E. den; Breuers, M.; Cremer, F.; Kemp, R.A.W.; Roos, M.; Schutte, K.; Vries, J.S. de


    Forest fire detection is a very important issue in the pre-suppression process. Timely detection allows the suppression units to reach the fire in its initial stages and this will reduce the suppression costs considerably. The autonomous forest fire detection principle is based on temporal contrast

  9. Cotidianos de famílias de crianças convivendo com doenças crônicas: microssistemas em intersecção com vulnerabilidades individuais Diario de vida de las familias de los niños que viven con enfermedades crónicas: microsistemas en la intersección con la vulnerabilidad individual Daily life of children living with chronic diseases: microsystems in the intersection with individual vulnerability

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes Rodrigues Pedroso


    familiar como objeto de la construcción del componente individual de la vulnerabilidad. La búsqueda de una intersección muestra que un componente individual de la vulnerabilidad tiene reflejos en la constitución del microsistema, lo que reafirma la importancia de visualizar el individuo como el objeto de la construcción y también como el constructor del ambiente donde transcurre su existencia.Vulnerability situations the environment where a child and its family are inserted may be translated into life and development conditions. This study aimed to learn the perceptions by the family of vulnerability situations and its components, related to the ecological environment, in children who face chronic diseases, hospitalized in a Hospital School in the city of Porto Alegre, Rio Grande do Sul, Brazil. It is a quantitative research from the perspective of a descriptive exploratory study. Data was collected from nine participants, by using dynamic activities of creativity and sensibility, analyzed according to the Content Analysis referential. Three categories of analysis emerged, and here the familiar micro-system was explored as construct of the individual component of vulnerability. The search for an intersection demonstrates that an individual component of vulnerability has reflexes on the micro-system constitution, which reinforces the importance of envisioning the individual as construct and constructor of the environment where his/her existence takes place.

  10. Can Gravitons Be Detected?

    CERN Document Server

    Rothman, T; Boughn, Stephen; Rothman, Tony


    Freeman Dyson has questioned whether any conceivable experiment in the real universe can detect a single graviton. If not, is it meaningful to talk about gravitons as physical entities? We attempt to answer Dyson's question and find it is possible concoct an idealized thought experiment capable of detecting one graviton; however, when anything remotely resembling realistic physics is taken into account, detection becomes impossible, indicating that Dyson's conjecture is very likely true. We also point out several mistakes in the literature dealing with graviton detection and production.

  11. Explicit Content Image Detection

    Directory of Open Access Journals (Sweden)

    Jorge Alberto Marcial Basilio


    Full Text Available This paper proposes a system gives for explicit content image detection based on Computer VisionAlgorithms, pattern recognition and FTK software Explicit Image Detection. In the first stage, HSV colormodel is used for the input images for the purpose of discriminating elements that are not human skinimages. Then the image is filtered using skin detection. The output image only contains the areas of whichit is composed. The results show a comparison between the proposed system and the company softwareAccess Data called Forensic Toolkit 3.1 Explicit Image Detection isperformed.

  12. Explicit Content Image Detection

    Directory of Open Access Journals (Sweden)

    Jorge Alberto Marcial Basilio


    Full Text Available This paper proposes a system gives for explicit content image detection based on Computer Vision Algorithms, pattern recognition and FTK software Explicit Image Detection. In the first stage, HSV color model is used for the input images for the purpose of discriminating elements that are not human skin images. Then the image is filtered using skin detection. The output image only contains the areas of which it is composed. The results show a comparison between the proposed system and the company software Access Data called Forensic Toolkit 3.1 Explicit Image Detection isperformed.

  13. Lean blowoff detection sensor (United States)

    Thornton, Jimmy; Straub, Douglas L.; Chorpening, Benjamin T.; Huckaby, David


    Apparatus and method for detecting incipient lean blowoff conditions in a lean premixed combustion nozzle of a gas turbine. A sensor near the flame detects the concentration of hydrocarbon ions and/or electrons produced by combustion and the concentration monitored as a function of time are used to indicate incipient lean blowoff conditions.

  14. Array for detecting microbes

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, Gary L.; DeSantis, Todd D.


    The present embodiments relate to an array system for detecting and identifying biomolecules and organisms. More specifically, the present embodiments relate to an array system comprising a microarray configured to simultaneously detect a plurality of organisms in a sample at a high confidence level.

  15. Detecting Illicit Nuclear Materials

    Energy Technology Data Exchange (ETDEWEB)

    Kouzes, Richard T.


    The threat that weapons of mass destruction might enter the United States has led to a number of efforts for the detection and interdiction of nuclear, radiological, chemical, and biological weapons at our borders. There have been multiple deployments of instrumentation to detect radiation signatures to interdict radiological material, including weapons and weapons material worldwide.

  16. Fraud detection tools

    Directory of Open Access Journals (Sweden)

    Katerina Hawlova


    Full Text Available This article aims to introduce to readers the topic of fraud management – detection of fraudulent behaviour. The article is divided into two parts. The first part presents what is meant by fraud and fraudulent behaviour. In the second part a case study dealing with fraudulent behaviour detection in the procurement area is introduced.

  17. Semiconductor radiation detection systems

    CERN Document Server


    Covers research in semiconductor detector and integrated circuit design in the context of medical imaging using ionizing radiation. This book explores other applications of semiconductor radiation detection systems in security applications such as luggage scanning, dirty bomb detection and border control.

  18. Analogue MIMO Detection

    Directory of Open Access Journals (Sweden)

    McNamara Darren


    Full Text Available In this contribution we propose an analogue receiver that can perform turbo detection in MIMO systems. We present the case for a receiver that is built from nonlinear analogue devices, which perform detection in a "free-flow" network (no notion of iterations. This contribution can be viewed as an extension of analogue turbo decoder concepts to include MIMO detection. These first analogue implementations report reductions of few orders of magnitude in the number of required transistors and in consumed energy, and the same order of improvement in processing speed. It is anticipated that such analogue MIMO decoder could bring about the same advantages, when compared to traditional digital implementations.

  19. Light Detection And Ranging (United States)

    U.S. Geological Survey, Department of the Interior — LiDAR (Light Detection and Ranging) discrete-return point cloud data are available in the American Society for Photogrammetry and Remote Sensing (ASPRS) LAS format....

  20. Anomaly Detection in Sequences (United States)

    National Aeronautics and Space Administration — We present a set of novel algorithms which we call sequenceMiner, that detect and characterize anomalies in large sets of high-dimensional symbol sequences that...

  1. Lead Poison Detection (United States)


    With NASA contracts, Whittaker Corporations Space Science division has developed an electro-optical instrument to mass screen for lead poisoning. Device is portable and detects protoporphyrin in whole blood. Free corpuscular porphyrins occur as an early effect of lead ingestion. Also detects lead in urine used to confirm blood tests. Test is inexpensive and can be applied by relatively unskilled personnel. Similar Whittaker fluorometry device called "drug screen" can measure morphine and quinine in urine much faster and cheaper than other methods.

  2. Sensor for metal detection

    KAUST Repository

    Kodzius, Rimantas


    NOVELTY - The sensor has a microfluidic flow channel that is provided with an inlet port, an outlet port, and a detection chamber. The detection chamber is provided with a group of sensing electrodes (4) having a working electrode (8), a counter electrode (9), and a reference electrode (10). A flow sensor is configured to measure flow in the channel. A temperature sensor (6) is configured to measure temperature in the channel (3). An electrical connection is configured to connect the sensor to a sensing device. USE - Sensor for detecting metal such as toxic metal in sample such as clinical sample such as stool, saliva, sputum, bronchial lavage, urine, vaginal swab, nasal swab, biopsy, tissue, tears, breath, blood, serum, plasma, cerebrospinal fluid, peritoneal fluid, pleural fluid, pericardial fluid, joint fluid, and amniotic fluid, water sample, food sample, air sample, and soil sample (all claimed). ADVANTAGE - The sensor for use with the portable analytical instrument is configured for detection of metalsin samples. The sensor can provide the excellent solution for on-site metal detection, including heavy metal detection. The sensors can provide significant advantages in higher throughput, lower cost, at the same time being less labor intensive and less dependent on individual skills. The disposable design of the sensor, the enhanced reliability and repeatability of measurements can be obtained. The sensors can be widely applied in various industries. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a system for detecting metal in sample; and (2) a method for using sensor for detecting metal in sample. DESCRIPTION OF DRAWING(S) - The drawing shows a schematic view of the sensor prototype. Channel (3) Sensing electrodes (4) Temperature sensor (6) Working electrode (8) Counter electrode (9) Reference electrode (10)

  3. Object Duplicate Detection


    Vajda, Péter


    With the technological evolution of digital acquisition and storage technologies, millions of images and video sequences are captured every day and shared in online services. One way of exploring this huge volume of images and videos is through searching a particular object depicted in images or videos by making use of object duplicate detection. Therefore, need of research on object duplicate detection is validated by several image and video retrieva...

  4. Dengue disease outbreak detection. (United States)

    Dayama, Pankaj; Sampath, Kameshwaran


    Early detection of outbreak of a disease may help in timely and effective public health interventions. Our motivation for this work is to assist EHD planning officer to analyze the incidence data and based on it declare whether there is an outbreak or not. In this paper, we develop ensemble of multiple techniques for detecting dengue disease outbreak. These techniques are applied to dengue incidence data from Singapore and results are summarized.

  5. Emotion Detection from Text

    CERN Document Server

    Shivhare, Shiv Naresh


    Emotion can be expressed in many ways that can be seen such as facial expression and gestures, speech and by written text. Emotion Detection in text documents is essentially a content - based classification problem involving concepts from the domains of Natural Language Processing as well as Machine Learning. In this paper emotion recognition based on textual data and the techniques used in emotion detection are discussed.

  6. Methods of Endotoxin Detection. (United States)

    Su, Wenqiong; Ding, Xianting


    Endotoxin, present in the outer membrane of all gram-negative bacteria, can pose serious risks to human health, from irreversible shock to death. Therefore, it is essential to develop sensitive, accurate, and rapid methods for its detection. The rabbit pyrogen test is the first standard technique for endotoxin detection and, nowadays, has been replaced by the Limulus Amoebocyte Lysate test, which is the most popular detection technique for endotoxin. With in-depth understanding of endotoxin, biosensors based on endotoxin-sensing components are promising alternatives to pursue in developing low-cost, easy-operation, and fast-response endotoxin detection techniques. This article summarizes the recent advances of endotoxin detection methods with a particular emphasis on optical and electrochemical biosensors based on various sensing elements ranging from nature biomolecules to artificial materials. As the research and technological revolution continues, the highly integrated and miniaturized commercial devices for sensitively and reliably detecting endotoxin will provide a wide range of applications in people's daily life.

  7. Proactive malware detection (United States)

    Gloster, Jonathan; Diep, Michael; Dredden, David; Mix, Matthew; Olsen, Mark; Price, Brian; Steil, Betty


    Small-to-medium sized businesses lack resources to deploy and manage high-end advanced solutions to deter sophisticated threats from well-funded adversaries, but evidence shows that these types of businesses are becoming key targets. As malicious code and network attacks become more sophisticated, classic signature-based virus and malware detection methods are less effective. To augment the current malware methods of detection, we developed a proactive approach to detect emerging malware threats using open source tools and intelligence to discover patterns and behaviors of malicious attacks and adversaries. Technical and analytical skills are combined to track adversarial behavior, methods and techniques. We established a controlled (separated domain) network to identify, monitor, and track malware behavior to increase understanding of the methods and techniques used by cyber adversaries. We created a suite of tools that observe the network and system performance looking for anomalies that may be caused by malware. The toolset collects information from open-source tools and provides meaningful indicators that the system was under or has been attacked. When malware is discovered, we analyzed and reverse engineered it to determine how it could be detected and prevented. Results have shown that with minimum resources, cost effective capabilities can be developed to detect abnormal behavior that may indicate malicious software.

  8. Forensic audio watermark detection (United States)

    Steinebach, Martin; Zmudzinski, Sascha; Petrautzki, Dirk


    Digital audio watermarking detection is often computational complex and requires at least as much audio information as required to embed a complete watermark. In some applications, especially real-time monitoring, this is an important drawback. The reason for this is the usage of sync sequences at the beginning of the watermark, allowing a decision about the presence only if at least the sync has been found and retrieved. We propose an alternative method for detecting the presence of a watermark. Based on the knowledge of the secret key used for embedding, we create a mark for all potential marking stages and then use a sliding window to test a given audio file on the presence of statistical characteristics caused by embedding. In this way we can detect a watermark in less than 1 second of audio.

  9. Neurology and detective writing. (United States)

    Kempster, Peter A; Lees, Andrew J


    When searching for clues to reach a diagnosis, neurologists often empathise with the detective who is trying to solve a case. The premise of this article is that detective stories have been part of the fabric of neurology ever since the time that it evolved into a discrete medical speciality. We will examine how this form of narrative has found expression in detective mystery fiction and popular science publications created by 20th century neurologist physician-writers. We will also investigate the power of the neurologist's alter ego, Sherlock Holmes: his relationship to founders of clinical neuroscience such as Jean-Martin Charcot, William Gowers and Sigmund Freud, and his influences on neurological practice and its literary traditions.

  10. Changing change detection

    DEFF Research Database (Denmark)

    Kyllingsbæk, Søren; Bundesen, Claus


    The change detection paradigm is a popular way of measuring visual short-term memory capacity. Using the paradigm, researchers have found evidence for a capacity of about four independent visual objects, confirming classic estimates that were based on the number of items that could be reported....... Here, we determine the reliability of capacity measures found by change detection. We derive theoretical predictions of the variance of the capacity estimates and show how they depend on the number of items to be remembered and the guessing strategy of the observer. We compare the theoretically derived...... variance to the variance estimated over repeated blocks of trials with the same observer and find close correspondence between predicted and observed variances. Also, we propose a new version of the two-alternative choice change detection paradigm, in which the choice is unforced. This new paradigm reduces...

  11. Detection of solar events (United States)

    Fischbach, Ephraim; Jenkins, Jere


    A flux detection apparatus can include a radioactive sample having a decay rate capable of changing in response to interaction with a first particle or a field, and a detector associated with the radioactive sample. The detector is responsive to a second particle or radiation formed by decay of the radioactive sample. The rate of decay of the radioactive sample can be correlated to flux of the first particle or the field. Detection of the first particle or the field can provide an early warning for an impending solar event.

  12. Detecting Patterns of Anomalies (United States)


    detect anomalies in the dataset is used in [Leung and Leckie, 2005] and [Eskin et al., 2002]. One-class SVMs [Li et al., 2003, Heller et al., 2003] and...IEE Proceedings F, 140(2): 107–113, 1993. J.D.F. Habbema, J. Hermans , and K. Vandenbroek. A stepwise discriminant analysis pro- gram using density...Technometrics, 29(4):409–412, 1987. K.A. Heller , K.M. Svore, A. Keromytis, and S.J. Stolfo. One class support vector machines for detecting anomalous

  13. Handbook for Language Detectives

    DEFF Research Database (Denmark)

    Bryanne, Ulla; Bruntt, Karen Scheel Lassen

    Handbook for Language Detectives gives a thorough presentation of English grammar and discusses how to teach grammar. The book unveils to the readers, who will be working as grammar detectives, the fascinating world of language. It does not only deal with "traditional grammar" but also discusses...... be done. The book serves a double purpose: - English grammar and language usage at bachelor level from a functional linguistic point of view. - How to teach English grammar within a communicative approach. The book is mainly intended for Danish student teachers of English, but anyone else interested...

  14. Readers as research detectives

    Directory of Open Access Journals (Sweden)

    Gøtzsche Peter C


    Full Text Available Abstract Flaws in research papers are common but it may require arduous detective work to unravel them. Checklists are helpful, but many inconsistencies will only be revealed through repeated cross-checks of every little detail, just like in a crime case. As a major deterrent for dishonesty, raw data from all trials should be posted on a public website. This would also make it much easier to detect errors and flaws in publications, and it would allow many research projects to be performed without collecting new data. The prevailing culture of secrecy and ownership to data is not in the best interests of patients.

  15. Readers as research detectives

    DEFF Research Database (Denmark)

    Gøtzsche, Peter C


    Flaws in research papers are common but it may require arduous detective work to unravel them. Checklists are helpful, but many inconsistencies will only be revealed through repeated cross-checks of every little detail, just like in a crime case. As a major deterrent for dishonesty, raw data from...... all trials should be posted on a public website. This would also make it much easier to detect errors and flaws in publications, and it would allow many research projects to be performed without collecting new data. The prevailing culture of secrecy and ownership to data is not in the best interests...

  16. Pretentiously detecting power cancellation

    CERN Document Server

    Jung, Junehyuk


    Granville and Soundararajan have recently introduced the notion of pretentiousness in the study of multiplicative functions of modulus bounded by 1, essentially the idea that two functions which are similar in a precise sense should exhibit similar behavior. It turns out, somewhat surprisingly, that this does not directly extend to detecting power cancellation - there are multiplicative functions which exhibit as much cancellation as possible in their partial sums that, modified slightly, give rise to functions which exhibit almost as little as possible. We develop two new notions of pretentiousness under which power cancellation can be detected, one of which applies to a much broader class of multiplicative functions.

  17. Sequential Detection of Digital Watermarking

    Institute of Scientific and Technical Information of China (English)

    LI Li; YU Yu-lian; WANG Pei


    The paper analyzed a new watermarking detection paradigm including double detection thresholds based on sequential hypothesis testing. A joint design of watermarking encoding and detection was proposed. The paradigm had good immunity to noisy signal attacks and high detection probability. Many experiments proved that the above algorithm can detect watermarks about 66% faster than popular detectors, which could have significant impact on many applications such as video watermarking detection and watermark-searching in a large database of digital contents.

  18. Immunity Based Worm Detection System

    Institute of Scientific and Technical Information of China (English)

    HONG Zheng; WU Li-fa; WANG Yuan-yuan


    Current worm detection methods are unable to detect multi-vector polymorphic worms effectively.Based on negative selection mechanism of the immune system,a local network worm detection system that detects worms was proposed.Normal network service requests were represented by self-strings,and the detection system used self-strings to monitor the network for anomaly.According to the properties of worm propagation,a control center correlated the anomalies detected in the form of binary trees to ensure the accuracy of worm detection.Experiments show the system to be effective in detecting the traditional as well as multi-vector polymorphic worms.

  19. Detecting Android Malware Using Clone Detection

    Institute of Scientific and Technical Information of China (English)

    陈健; Manar H. Alalfi; Member; ACM; IEEE; Thomas R. Dean; 邹颖


    Android is currently one of the most popular smartphone operating systems. However, Android has the largest share of global mobile malware and significant public attention has been brought to the security issues of Android. In this paper, we investigate the use of a clone detector to identify known Android malware. We collect a set of Android applications known to contain malware and a set of benign applications. We extract the Java source code from the binary code of the applications and use NiCad, a near-miss clone detector, to find the classes of clones in a small subset of the malicious applications. We then use these clone classes as a signature to find similar source files in the rest of the malicious applications. The benign collection is used as a control group. In our evaluation, we successfully decompile more than 1 000 malicious apps in 19 malware families. Our results show that using a small portion of malicious applications as a training set can detect 95% of previously known malware with very low false positives and high accuracy at 96.88%. Our method can effectively and reliably pinpoint malicious applications that belong to certain malware families.

  20. Detection of colorectal neoplasia

    DEFF Research Database (Denmark)

    Wilhelmsen, Michael; Christensen, Ib J; Rasmussen, Louise


    Serological biomarkers may be an option for early detection of colorectal cancer (CRC). The present study assessed 8 cancer-associated protein biomarkers in plasma from subjects undergoing first time ever colonoscopy due to symptoms attributable to colorectal neoplasia. Plasma AFP, CA19-9, CEA, hs...

  1. Evolutionary Theories of Detection

    Energy Technology Data Exchange (ETDEWEB)

    Fitch, J P


    Current, mid-term and long range technologies for detection of pathogens and toxins are briefly described in the context of performance metrics and operational scenarios. Predictive (evolutionary) and speculative (revolutionary) assessments are given with trade-offs identified, where possible, among competing performance goals.

  2. Electrically detected ferromagnetic resonance

    NARCIS (Netherlands)

    Goennenwein, S.T.B.; Schink, S.W.; Brandlmaier, A.; Boger, A.; Opel, M.; Gross, R.; Keizer, R.S.; Klapwijk, T.M.; Gupta, A.; Huebl, H.; Bihler, C.; Brandt, M.S.


    We study the magnetoresistance properties of thin ferromagnetic CrO2 and Fe3O4 films under microwave irradiation. Both the sheet resistance ρ and the Hall voltage VHall characteristically change when a ferromagnetic resonance (FMR) occurs in the film. The electrically detected ferromagnetic resonanc

  3. Automatic detection of laughter

    NARCIS (Netherlands)

    Truong, K.P.; Leeuwen, D.A. van


    In the context of detecting ‘paralinguistic events’ with the aim to make classification of the speaker’s emotional state possible, a detector was developed for one of the most obvious ‘paralinguistic events’, namely laughter. Gaussian Mixture Models were trained with Perceptual Linear Prediction fea

  4. Soybean allergen detection methods

    DEFF Research Database (Denmark)

    Pedersen, Mona H; Holzhauser, Thomas; Bisson, Caroline


    Soybean containing products are widely consumed, thus reliable methods for detection of soy in foods are needed in order to make appropriate risk assessment studies to adequately protect soy allergic patients. Six methods were compared using eight food products with a declared content of soy...

  5. Change Detection Tools

    NARCIS (Netherlands)

    Dekker, R.J.; Kuenzer, C.; Lehner, M.; Reinartz, P.; Niemeyer, I.; Nussbaum, S.; Lacroix, V.; Sequeira, V.; Stringa, E.; Schöpfer, E.


    In this chapter a wide range of change detection tools is addressed. They are grouped into methods suitable for optical and multispectral data, synthetic aperture radar (SAR) images, and 3D data. Optical and multispectral methods include unsupervised approaches, supervised and knowledge-based approa

  6. Detection of counterfeit currency (United States)

    Burns, D.A.


    A method is disclosed of detecting counterfeit currency by contacting the currency to be tested with near infrared beams in the spectrum below 1,250 nanometers, measuring reflectance of the near infrared beams and comparing the reflectance values with those from genuine currency. 18 figs.

  7. Global Disease Detectives

    Centers for Disease Control (CDC) Podcasts


    This podcast documents U.S. efforts to prevent, detect, and control emerging infectious diseases, such as SARS and pandemic influenza.  Created: 9/21/2010 by CDC Center for Global Health.   Date Released: 9/21/2010.

  8. Electrical load detection aparatus

    DEFF Research Database (Denmark)


    A load detection technique for a load comprising multiple frequency-dependant sub-loads comprises measuring a representation of the impedance characteristic of the load; providing stored representations of a multiplicity of impedance characteristics of the load; each one of the stored representat...

  9. Portable raman explosives detection

    Energy Technology Data Exchange (ETDEWEB)

    Moore, David Steven [Los Alamos National Laboratory; Scharff, Robert J [Los Alamos National Laboratory


    Recent advances in portable Raman instruments have dramatically increased their application to emergency response and forensics, as well as homeland defense. This paper reviews the relevant attributes and disadvantages of portable Raman spectroscopy, both essentially and instrumentally, to the task of explosives detection in the field.

  10. Bayesian microsaccade detection (United States)

    Mihali, Andra; van Opheusden, Bas; Ma, Wei Ji


    Microsaccades are high-velocity fixational eye movements, with special roles in perception and cognition. The default microsaccade detection method is to determine when the smoothed eye velocity exceeds a threshold. We have developed a new method, Bayesian microsaccade detection (BMD), which performs inference based on a simple statistical model of eye positions. In this model, a hidden state variable changes between drift and microsaccade states at random times. The eye position is a biased random walk with different velocity distributions for each state. BMD generates samples from the posterior probability distribution over the eye state time series given the eye position time series. Applied to simulated data, BMD recovers the “true” microsaccades with fewer errors than alternative algorithms, especially at high noise. Applied to EyeLink eye tracker data, BMD detects almost all the microsaccades detected by the default method, but also apparent microsaccades embedded in high noise—although these can also be interpreted as false positives. Next we apply the algorithms to data collected with a Dual Purkinje Image eye tracker, whose higher precision justifies defining the inferred microsaccades as ground truth. When we add artificial measurement noise, the inferences of all algorithms degrade; however, at noise levels comparable to EyeLink data, BMD recovers the “true” microsaccades with 54% fewer errors than the default algorithm. Though unsuitable for online detection, BMD has other advantages: It returns probabilities rather than binary judgments, and it can be straightforwardly adapted as the generative model is refined. We make our algorithm available as a software package. PMID:28114483

  11. Mask Blank Defect Detection

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, M A; Sommargren, G E


    Mask blanks are the substrates that hold the master patterns for integrated circuits. Integrated circuits are semiconductor devices, such as microprocessors (mPs), dynamic random access memory (DRAMs), and application specific integrated circuits (ASICs) that are central to the computer, communication, and electronics industries. These devices are fabricated using a set of master patterns that are sequentially imaged onto light-sensitive coated silicon wafers and processed to form thin layers of insulating and conductive materials on top of the wafer. These materials form electrical paths and transistors that control the flow of electricity through the device. For the past forty years the semiconductor industry has made phenomenal improvements in device functionality, compactness, speed, power, and cost. This progress is principally due to the exponential decrease in the minimum feature size of integrated circuits, which has been reduced by a factor of {radical}2 every three years. Since 1992 the Semiconductor Industry Association (SIA) has coordinated the efforts of producing a technology roadmap for semiconductors. In the latest document, ''The International Technology Roadmap for Semiconductors: 1999'', future technology nodes (minimum feature sizes) and targeted dates were specified and are summarized in Table 1. Lithography is the imaging technology for producing a de-magnified image of the mask on the wafer. A typical de-magnification factor is 4. Mask blank defects as small as one-eighth the equivalent minimum feature size are printable and may cause device failure. Defects might be the result of the surface preparation, such as polishing, or contamination due to handling or the environment. Table 2 shows the maximum tolerable defect sizes on the mask blank for each technology node. This downward trend puts a tremendous burden on mask fabrication, particularly in the area of defect detection and reduction. A new infrastructure for mask

  12. Exoplanet Detection Techniques

    CERN Document Server

    Fischer, Debra A; Laughlin, Greg P; Macintosh, Bruce; Mahadevan, Suvrath; Sahlmann, Johannes; Yee, Jennifer C


    We are still in the early days of exoplanet discovery. Astronomers are beginning to model the atmospheres and interiors of exoplanets and have developed a deeper understanding of processes of planet formation and evolution. However, we have yet to map out the full complexity of multi-planet architectures or to detect Earth analogues around nearby stars. Reaching these ambitious goals will require further improvements in instrumentation and new analysis tools. In this chapter, we provide an overview of five observational techniques that are currently employed in the detection of exoplanets: optical and IR Doppler measurements, transit photometry, direct imaging, microlensing, and astrometry. We provide a basic description of how each of these techniques works and discuss forefront developments that will result in new discoveries. We also highlight the observational limitations and synergies of each method and their connections to future space missions.

  13. Acoustic detection of pneumothorax (United States)

    Mansy, Hansen A.; Royston, Thomas J.; Balk, Robert A.; Sandler, Richard H.


    This study aims at investigating the feasibility of using low-frequency (pneumothorax detection were tested in dogs. In the first approach, broadband acoustic signals were introduced into the trachea during end-expiration and transmitted waves were measured at the chest surface. Pneumothorax was found to consistently decrease pulmonary acoustic transmission in the 200-1200-Hz frequency band, while less change was observed at lower frequencies (ppneumothorax states (pPneumothorax was found to be associated with a preferential reduction of sound amplitude in the 200- to 700-Hz range, and a decrease of sound amplitude variation (in the 300 to 600-Hz band) during the respiration cycle (pPneumothorax changed the frequency and decay rate of percussive sounds. These results imply that certain medical conditions may be reliably detected using appropriate acoustic measurements and analysis. [Work supported by NIH/NHLBI #R44HL61108.

  14. Solar neutrino detection

    CERN Document Server

    Miramonti, Lino


    More than 40 years ago, neutrinos where conceived as a way to test the validity of the solar models which tell us that stars are powered by nuclear fusion reactions. The first measurement of the neutrino flux, in 1968 in the Homestake mine in South Dakota, detected only one third of the expected value, originating what has been known as the Solar Neutrino Problem. Different experiments were built in order to understand the origin of this discrepancy. Now we know that neutrinos undergo oscillation phenomenon changing their nature traveling from the core of the Sun to our detectors. In the work the 40 year long saga of the neutrino detection is presented; from the first proposals to test the solar models to last real time measurements of the low energy part of the neutrino spectrum.

  15. Chaos detection and predictability

    CERN Document Server

    Gottwald, Georg; Laskar, Jacques


    Distinguishing chaoticity from regularity in deterministic dynamical systems and specifying the subspace of the phase space in which instabilities are expected to occur is of utmost importance in as disparate areas as astronomy, particle physics and climate dynamics.   To address these issues there exists a plethora of methods for chaos detection and predictability. The most commonly employed technique for investigating chaotic dynamics, i.e. the computation of Lyapunov exponents, however, may suffer a number of problems and drawbacks, for example when applied to noisy experimental data.   In the last two decades, several novel methods have been developed for the fast and reliable determination of the regular or chaotic nature of orbits, aimed at overcoming the shortcomings of more traditional techniques. This set of lecture notes and tutorial reviews serves as an introduction to and overview of modern chaos detection and predictability techniques for graduate students and non-specialists.   The book cover...

  16. Gas Detection for Experiments

    CERN Document Server

    Hay, D


    Flammable gases are often used in detectors for physics experiments. The storage, distribution and manipulation of such flammable gases present several safety hazards. As most flammable gases cannot be detected by human senses, specific well-placed gas detection systems must be installed. Following a request from the user group and in collaboration with CERN safety officers, risk analyses are performed. An external contractor, who needs to receive detailed user requirements from CERN, performs the installations. The contract is passed on a guaranteed results basis. Co-ordination between all the CERN groups and verification of the technical installation is done by ST/AA/AS. This paper describes and focuses on the structured methodology applied to implement such installations based on goal directed project management techniques (GDPM). This useful supervision tool suited to small to medium sized projects facilitates the task of co-ordinating numerous activities to achieve a completely functional system.

  17. Bayesian community detection

    DEFF Research Database (Denmark)

    Mørup, Morten; Schmidt, Mikkel N


    Many networks of scientific interest naturally decompose into clusters or communities with comparatively fewer external than internal links; however, current Bayesian models of network communities do not exert this intuitive notion of communities. We formulate a nonparametric Bayesian model...... consistent with ground truth, and on real networks, it outperforms existing approaches in predicting missing links. This suggests that community structure is an important structural property of networks that should be explicitly modeled....... for community detection consistent with an intuitive definition of communities and present a Markov chain Monte Carlo procedure for inferring the community structure. A Matlab toolbox with the proposed inference procedure is available for download. On synthetic and real networks, our model detects communities...

  18. Skin Cancer Detection

    Directory of Open Access Journals (Sweden)

    N. Durga Rao


    Full Text Available : In recent days, skin cancer is seen as one of the most Hazardous form of the Cancers found in Humans. Skin cancer is found in various types such as Melanoma, Basal and Squamous cell Carcinoma among which Melanoma is the most unpredictable. The detection of Melanoma cancer in early stage can be helpful to cure it. Computer vision can play important role in Medical Image Diagnosis and it has been proved by many existing systems. In this paper, we present a survey on different steps which are being to detect the Melanoma Skin Cancer using Image Processing tools. In every step, what are the different methods are be included in our paper

  19. Exoplanet Detection Methods

    CERN Document Server

    Wright, Jason T


    This chapter reviews various methods of detecting planetary companions to stars from an observational perspective, focusing on radial velocities, astrometry, direct imaging, transits, and gravitational microlensing. For each method, this chapter first derives or summarizes the basic observable phenomena that are used to infer the ex- istence of planetary companions, as well as the physical properties of the planets and host stars that can be derived from the measurement of these signals. This chapter then outlines the general experimental requirements to robustly detect the signals us- ing each method, by comparing their magnitude to the typical sources of measurement uncertainty. This chapter goes on to compare the various methods to each other by outlining the regions of planet and host star parameter space where each method is most sensitive, stressing the complementarity of the ensemble of the methods at our disposal. Finally, there is a brief review of the history of the young exoplanet field, from the f...

  20. Early detection of psychosis

    DEFF Research Database (Denmark)

    Larsen, T. K.; Melle, I.; Auestad, B.


    Background During the last decades we have seen a new focus on early treatment of psychosis. Several reviews have shown that duration of untreated psychosis (DUP) is correlated to better outcome. However, it is still unknown whether early treatment will lead to a better long-term outcome....... This study reports the effects of reducing DUP on 5-year course and outcome.Method During 1997â€"2000 a total of 281 consecutive patients aged >17 years with first episode non-affective psychosis were recruited, of which 192 participated in the 5-year follow-up. A comprehensive early detection (ED) programme...... with public information campaigns and low-threshold psychosis detection teams was established in one healthcare area (ED-area), but not in a comparable area (no-ED area). Both areas ran equivalent treatment programmes during the first 2 years and need-adapted treatment thereafter.Results At the start...

  1. Cell Phone Detection Techniques

    Energy Technology Data Exchange (ETDEWEB)

    Pratt, Richard M.; Bunch, Kyle J.; Puzycki, David J.; Slaugh, Ryan W.; Good, Morris S.; McMakin, Douglas L.


    A team composed of Rick Pratt, Dave Puczyki, Kyle Bunch, Ryan Slaugh, Morris Good, and Doug McMakin teamed together to attempt to exploit cellular telephone features and detect if a person was carrying a cellular telephone into a Limited Area. The cell phone’s electromagnetic properties were measured, analyzed, and tested in over 10 different ways to determine if an exploitable signature exists. The method that appears to have the most potential for success without adding an external tag is to measure the RF spectrum, not in the cell phone band, but between 240 and 400MHz. Figures 1- 7 show the detected signal levels from cell phones from three different manufacturers.

  2. Benchtop Detection of Proteins (United States)

    Scardelletti, Maximilian C.; Varaljay, Vanessa


    A process, and a benchtop-scale apparatus for implementing the process, have been developed to detect proteins associated with specific microbes in water. The process and apparatus may also be useful for detection of proteins in other, more complex liquids. There may be numerous potential applications, including monitoring lakes and streams for contamination, testing of blood and other bodily fluids in medical laboratories, and testing for microbial contamination of liquids in restaurants and industrial food-processing facilities. A sample can be prepared and analyzed by use of this process and apparatus within minutes, whereas an equivalent analysis performed by use of other processes and equipment can often take hours to days. The process begins with the conjugation of near-infrared-fluorescent dyes to antibodies that are specific to a particular protein. Initially, the research has focused on using near-infrared dyes to detect antigens or associated proteins in solution, which has proven successful vs. microbial cells, and streamlining the technique in use for surface protein detection on microbes would theoretically render similar results. However, it is noted that additional work is needed to transition protein-based techniques to microbial cell detection. Consequently, multiple such dye/antibody pairs could be prepared to enable detection of multiple selected microbial species, using a different dye for each species. When excited by near-infrared light of a suitable wavelength, each dye fluoresces at a unique longer wavelength that differs from those of the other dyes, enabling discrimination among the various species. In initial tests, the dye/antibody pairs are mixed into a solution suspected of containing the selected proteins, causing the binding of the dye/antibody pairs to such suspect proteins that may be present. The solution is then run through a microcentrifuge that includes a membrane that acts as a filter in that it retains the dye

  3. Sherlock Holmes: scientific detective. (United States)

    Snyder, Laura J


    Sherlock Holmes was intended by his creator, Arthur Conan Doyle, to be a 'scientific detective'. Conan Doyle criticized his predecessor Edgar Allan Poe for giving his creation - Inspector Dupin - only the 'illusion' of scientific method. Conan Doyle believed that he had succeeded where Poe had failed; thus, he has Watson remark that Holmes has 'brought detection as near an exact science as it will ever be brought into the world.' By examining Holmes' methods, it becomes clear that Conan Doyle modelled them on certain images of science that were popular in mid- to late-19th century Britain. Contrary to a common view, it is also evident that rather than being responsible for the invention of forensic science, the creation of Holmes was influenced by the early development of it.

  4. Passive MIMO Radar Detection (United States)


    from history to future”. Proc. 11th Int. Radar Symp. (IRS), 1–4. 2010. [58] Levanon, N. “ Interferometry against differential Doppler: performance...2141, 2013. [71] Richards, M. A., J. A. Scheer, and W. A. Holm. Principles of Modern Radar , volume 1. SciTech Publishing, Inc., 2010. [72] Scharf, L...PASSIVE MIMO RADAR DETECTION DISSERTATION Daniel E. Hack, Civilian AFIT-ENG-DS-13-S-07 DEPARTMENT OF THE AIR FORCE AIR UNIVERSITY AIR FORCE INSTITUTE

  5. Detection of pump degradation

    Energy Technology Data Exchange (ETDEWEB)

    Greene, R.H.; Casada, D.A.; Ayers, C.W. [and others


    This Phase II Nuclear Plant Aging Research study examines the methods of detecting pump degradation that are currently employed in domestic and overseas nuclear facilities. This report evaluates the criteria mandated by required pump testing at U.S. nuclear power plants and compares them to those features characteristic of state-of-the-art diagnostic programs and practices currently implemented by other major industries. Since the working condition of the pump driver is crucial to pump operability, a brief review of new applications of motor diagnostics is provided that highlights recent developments in this technology. The routine collection and analysis of spectral data is superior to all other technologies in its ability to accurately detect numerous types and causes of pump degradation. Existing ASME Code testing criteria do not require the evaluation of pump vibration spectra but instead overall vibration amplitude. The mechanical information discernible from vibration amplitude analysis is limited, and several cases of pump failure were not detected in their early stages by vibration monitoring. Since spectral analysis can provide a wealth of pertinent information concerning the mechanical condition of rotating machinery, its incorporation into ASME testing criteria could merit a relaxation in the monthly-to-quarterly testing schedules that seek to verify and assure pump operability. Pump drivers are not included in the current battery of testing. Operational problems thought to be caused by pump degradation were found to be the result of motor degradation. Recent advances in nonintrusive monitoring techniques have made motor diagnostics a viable technology for assessing motor operability. Motor current/power analysis can detect rotor bar degradation and ascertain ranges of hydraulically unstable operation for a particular pump and motor set. The concept of using motor current or power fluctuations as an indicator of pump hydraulic load stability is presented.

  6. Method for detecting biomolecules (United States)

    Huo, Qisheng; Liu, Jun


    A method for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with controllable pore size distribution characteristics applied to at least one surface of the conducting electrode. The film is functionalized with probe molecules that chemically interact with the target biomolecules at the film surface, blocking indicator molecules present in solution from diffusing from the solution to the electrode, thereby changing the electrochemical response of the electrode

  7. Nuclear material detection techniques (United States)

    Christian, James F.; Sia, Radia; Dokhale, Purushottam; Shestakova, Irina; Nagarkar, Vivek; Shah, Kanai; Johnson, Erik B.; Stapels, Christopher J.; Ryan, James M.; Macri, John; Bravar, Ulisse; Leung, Ka-Ngo; Squillante, Michael R.


    Illicit nuclear materials represent a threat for the safety of the American citizens, and the detection and interdiction of a nuclear weapon is a national problem that has not been yet solved. Alleviating this threat represents an enormous challenge to current detection methods that have to be substantially improved to identify and discriminate threatening from benign incidents. Rugged, low-power and less-expensive radiation detectors and imagers are needed for large-scale wireless deployment. Detecting the gamma rays emitted by nuclear and fissionable materials, particularly special nuclear materials (SNM), is the most convenient way to identify and locate them. While there are detectors that have the necessary sensitivity, none are suitable to meet the present need, primarily because of the high occurrence of false alarms. The exploitation of neutron signatures represents a promising solution to detecting illicit nuclear materials. This work presents the development of several detector configurations such as a mobile active interrogation system based on a compact RF-Plasma neutron generator developed at LBNL and a fast neutron telescope that uses plastic scintillating-fibers developed at the University of New Hampshire. A human-portable improved Solid-State Neutron Detector (SSND) intended to replace pressurized 3He-tubes will be also presented. The SSND uses an ultra-compact CMOS-SSPM (Solid-State Photomultiplier) detector, developed at Radiation Monitoring devices Inc., coupled to a neutron sensitive scintillator. The detector is very fast and can provide time and spectroscopy information over a wide energy range including fast neutrons.

  8. Dynamic Network Change Detection (United States)


    detection methods is presented; the cumulative sum ( CUSUM ), the exponentially weighted moving average (EWMA), and a scan statistic (SS). Statistical...minimizing the risk of false alarms. Three common SPC methods that we consider here are the CUSUM (Page, 1961), EWMA (Roberts, 1959), and the SS...successive dynamic network measures are then used to calculate the statistics for the CUSUM , the EWMA, and the SS. These are then compared to decision

  9. Aspects of leak detection

    Energy Technology Data Exchange (ETDEWEB)

    Chivers, T.C. [Berkeley Technology Centre, Glos (United Kingdom)


    A requirement of a Leak before Break safety case is that the leakage from the through wall crack be detected prior to any growth leading to unacceptable failure. This paper sets out to review some recent developments in this field. It does not set out to be a comprehensive guide to all of the methods available. The discussion concentrates on acoustic emission and how the techniques can be qualified and deployed on operational plant.

  10. Asynchrony Detection in Amblyopes

    Directory of Open Access Journals (Sweden)

    Pi-Chun Huang


    Full Text Available Amblyopia is a developmental abnormality of visual cortex. Although amblyopes experience perceptual deficits in spatial vision tasks, they have less temporal sensitivity loss. We investigated whether their temporal synchrony sensitivity is impaired. In experiment 1, four Gaussian blobs, located at the top, bottom, left, and right of a presentation screen, were flickering in 3 Hz and one of them was flickering in out-of-phase fashion in time. Participants needed to tell which blob was different from the other three and contrast threshold of the blobs was measured to determine the synchrony detection threshold. We found the thresholds were not correlated with the contrast thresholds for detecting the flickering blobs, suggesting synchrony detection and temporal detection threshold are processed by different mechanisms. In experiment 2, synchrony thresholds were measured as participants' ability to tell if one of the four high contrast Gaussian blobs was flickering asynchronously in time. Three temporal frequencies (1, 2, and 3 Hz and two element separations (1.25 and 5 deg were compared. We found that the amblyopic group exhibited a deficit only for the 1.25 deg element separation in amblyopic eye but was normal for the other configurations compared to controlled participants. It suggests amblyopes have deficits in temporal processing but only for foveal vision. We also found the sensitivity for the non-strabismic anismetropia group is reduced for all three temporal frequencies whereas for the strabismic anisometropia group it was reduced at 3Hz only, suggesting the impairment in temporal synchrony might be different for different types of amblyopia.

  11. CDC Disease Detective Camp

    Centers for Disease Control (CDC) Podcasts


    The CDC Disease Detective Camp gives rising high school juniors and seniors exposure to key aspects of the CDC, including basic epidemiology, infectious and chronic disease tracking, public health law, and outbreak investigations. The camp also helps students explore careers in public health.  Created: 8/2/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 8/2/2010.

  12. Cloud Detection with MATLAB


    P. Shrivastava


    The accurate detection of clouds in satellite imagery is important in research and operational applications. Cloud cover influences the distribution of solar radiation reaching the ground where it is absorbed. Resulting fluxes of sensible and latent heat are critical to the accurate characterization of boundary layer behavior and mesoscale circulations that often lead to convective development. Therefore the spatial and temporal variation in cloud cover can greatly affect regional an...

  13. Fraud Detection in Healthcare

    Energy Technology Data Exchange (ETDEWEB)

    Chandola, Varun [ORNL; Schryver, Jack C [ORNL; Sukumar, Sreenivas R [ORNL


    We discuss the problem of fraud detection in healthcare in this chapter. Given the recent scrutiny of the ineciencies in the US healthcare system, identifying fraud has been on the forefront of the eorts towards reducing the healthcare costs. In this chapter we will focus on understanding the issue of healthcare fraud in detail, and review methods that have been proposed in the literature to combat this issue using data driven approach.

  14. Extrasolar planet detection (United States)

    Korechoff, R. P.; Diner, D. J.; Tubbs, E. F.; Gaiser, S. L.


    This paper discusses the concept of extrasolar planet detection using a large-aperture infared imaging telescope. Coronagraphic stellar apodization techniques are less efficient at infrared wavelengths compared to the visible, as a result of practical limitations on aperture dimensions, thus necessitating additional starlight suppression to make planet detection feasible in this spectral domain. We have been investigating the use of rotational shearing interferometry to provide up to three orders of magnitude of starlight suppression over broad spectral bandwidths. We present a theoretical analysis of the system performance requirements needed to make this a viable instrument for planet detection, including specifications on the interferometer design and telescope aperture characteristics. The concept of using rotational shearing interferometry as a wavefront error detector, thus providing a signal that can be used to adaptively correct the wavefront, will be discussed. We also present the status of laboratory studies of on-axis source suppression using a recently constructed rotational shearing interferometer that currently operates in the visible.

  15. Nonlinear Multiantenna Detection Methods

    Directory of Open Access Journals (Sweden)

    Chen Sheng


    Full Text Available A nonlinear detection technique designed for multiple-antenna assisted receivers employed in space-division multiple-access systems is investigated. We derive the optimal solution of the nonlinear spatial-processing assisted receiver for binary phase shift keying signalling, which we refer to as the Bayesian detector. It is shown that this optimal Bayesian receiver significantly outperforms the standard linear beamforming assisted receiver in terms of a reduced bit error rate, at the expense of an increased complexity, while the achievable system capacity is substantially enhanced with the advent of employing nonlinear detection. Specifically, when the spatial separation expressed in terms of the angle of arrival between the desired and interfering signals is below a certain threshold, a linear beamformer would fail to separate them, while a nonlinear detection assisted receiver is still capable of performing adequately. The adaptive implementation of the optimal Bayesian detector can be realized using a radial basis function network. Two techniques are presented for constructing block-data-based adaptive nonlinear multiple-antenna assisted receivers. One of them is based on the relevance vector machine invoked for classification, while the other on the orthogonal forward selection procedure combined with the Fisher ratio class-separability measure. A recursive sample-by-sample adaptation procedure is also proposed for training nonlinear detectors based on an amalgam of enhanced -means clustering techniques and the recursive least squares algorithm.

  16. Human kin detection. (United States)

    Bressan, Paola; Kramer, Peter


    Natural selection has favored the evolution of behaviors that benefit not only one's genes, but also their copies in genetically related individuals. These behaviors include optimal outbreeding (choosing a mate that is neither too closely related, nor too distant), nepotism (helping kin), and spite (hurting non-kin at a personal cost), and all require some form of kin detection or kin recognition. Yet, kinship cannot be assessed directly; human kin detection relies on heuristic cues that take into account individuals' context (whether they were reared by our mother, or grew up in our home, or were given birth by our spouse), appearance (whether they smell or look like us), and ability to arouse certain feelings (whether we feel emotionally close to them). The uncertainties of kin detection, along with its dependence on social information, create ample opportunities for the evolution of deception and self-deception. For example, babies carry no unequivocal stamp of their biological father, but across cultures they are passionately claimed to resemble their mother's spouse; to the same effect, 'neutral' observers are greatly influenced by belief in relatedness when judging resemblance between strangers. Still, paternity uncertainty profoundly shapes human relationships, reducing not only the investment contributed by paternal versus maternal kin, but also prosocial behavior between individuals who are related through one or more males rather than females alone. Because of its relevance to racial discrimination and political preferences, the evolutionary pressure to prefer kin to non-kin has a manifold influence on society at large.

  17. Neutrino Detection With CLEAN

    CERN Document Server

    McKinsey, D N


    This article describes CLEAN, an approach to the detection of low-energy solar neutrinos and neutrinos released from supernovae. The CLEAN concept is based on the detection of elastic scattering events (neutrino-electron scattering and neutrino-nuclear scattering) in liquified noble gases such as liquid helium, liquid neon, and liquid xenon, all of which scintillate brightly in the ultraviolet. Key to the CLEAN technique is the use of a thin film of wavelength-shifting fluor to convert the ultraviolet scintillation light to the visible. This allows the same liquid to be used as both a passive shielding medium and an active self-shielding detector, allowing lower intrinsic radioactive backgrounds at low energies. Liquid neon is a particularly promising medium for CLEAN. Because liquid neon has a high scintillation yield, has no long-lived radioactive isotopes, and can be easily purified by use of cold traps, it is an ideal medium for the detection of rare nuclear events. In addition, neon is inexpensive, dense...

  18. Hand Detection Using HSV Model

    Directory of Open Access Journals (Sweden)

    Uzma Noreen


    Full Text Available Natural Human Computer Interaction HCI is the demand of todays technology oriented world. Detecting and tracking of face and hands are important for gesture recognition. Skin detection is a very popular and useful technique for detecting and tracking human-body parts. It has been much attention mainly because of its vast range of applications such as face detection and tracking naked people detection hand detection and tracking people retrieval in databases and Internet etc. Many models and algorithms are being used for detection of face hand and its gesture. Hand detection using model or classification is to build a decision rule that will discriminate between skin and non-skin pixels. Identifying skin color pixels involves finding the range of values for which most skin pixels would fall in a given color space. All external factors will be eliminated to detect the hand and its color in the image in complex background.

  19. Outlier Detection Method Use for the Network Flow Anomaly Detection

    Directory of Open Access Journals (Sweden)

    Rimas Ciplinskas


    Full Text Available New and existing methods of cyber-attack detection are constantly being developed and improved because there is a great number of attacks and the demand to protect from them. In prac-tice, current methods of attack detection operates like antivirus programs, i. e. known attacks signatures are created and attacks are detected by using them. These methods have a drawback – they cannot detect new attacks. As a solution, anomaly detection methods are used. They allow to detect deviations from normal network behaviour that may show a new type of attack. This article introduces a new method that allows to detect network flow anomalies by using local outlier factor algorithm. Accom-plished research allowed to identify groups of features which showed the best results of anomaly flow detection according the highest values of precision, recall and F-measure.

  20. Rapid Detection of Pathogens

    Energy Technology Data Exchange (ETDEWEB)

    David Perlin


    Pathogen identification is a crucial first defense against bioterrorism. A major emphasis of our national biodefense strategy is to establish fast, accurate and sensitive assays for diagnosis of infectious diseases agents. Such assays will ensure early and appropriate treatment of infected patients. Rapid diagnostics can also support infection control measures, which monitor and limit the spread of infectious diseases agents. Many select agents are highly transmissible in the early stages of disease, and it is critical to identify infected patients and limit the risk to the remainder of the population and to stem potential panic in the general population. Nucleic acid-based molecular approaches for identification overcome many of the deficiencies associated with conventional culture methods by exploiting both large- and small-scale genomic differences between organisms. PCR-based amplification of highly conserved ribosomal RNA (rRNA) genes, intergenic sequences, and specific toxin genes is currently the most reliable approach for bacterial, fungal and many viral pathogenic agents. When combined with fluorescence-based oligonucleotide detection systems, this approach provides real-time, quantitative, high fidelity analysis capable of single nucleotide allelic discrimination (4). These probe systems offer rapid turn around time (<2 h) and are suitable for high throughput, automated multiplex operations that are critical for clinical diagnostic laboratories. In this pilot program, we have used molecular beacon technology invented at the Public health Research Institute to develop a new generation of molecular probes to rapidly detect important agents of infectious diseases. We have also developed protocols to rapidly extract nucleic acids from a variety of clinical specimen including and blood and tissue to for detection in the molecular assays. This work represented a cooperative research development program between the Kramer-Tyagi/Perlin labs on probe development

  1. Theory of Edge Detection (United States)

    Marr, D.; Hildreth, E.


    A theory of edge detection is presented. The analysis proceeds in two parts. (1) Intensity changes, which occur in a natural image over a wide range of scales, are detected separately at different scales. An appropriate filter for this purpose at a given scale is found to be the second derivative of a Gaussian, and it is shown that, provided some simple conditions are satisfied, these primary filters need not be orientation-dependent. Thus, intensity changes at a given scale are best detected by finding the zero values of nabla 2G(x, y)* I(x, y) for image I, where G(x, y) is a two-dimensional Gaussian distribution and nabla 2 is the Laplacian. The intensity changes thus discovered in each of the channels are then represented by oriented primitives called zero-crossing segments, and evidence is given that this representation is complete. (2) Intensity changes in images arise from surface discontinuities or from reflectance or illumination boundaries, and these all have the property that they are spatially localized. Because of this, the zero-crossing segments from the different channels are not independent, and rules are deduced for combining them into a description of the image. This description is called the raw primal sketch. The theory explains several basic psychophysical findings, and the operation of forming oriented zero-crossing segments from the output of centre-surround nabla 2G filters acting on the image forms the basis for a physiological model of simple cells (see Marr & Ullman 1979).

  2. License plate detection algorithm (United States)

    Broitman, Michael; Klopovsky, Yuri; Silinskis, Normunds


    A novel algorithm for vehicle license plates localization is proposed. The algorithm is based on pixel intensity transition gradient analysis. Near to 2500 natural-scene gray-level vehicle images of different backgrounds and ambient illumination was tested. The best set of algorithm's parameters produces detection rate up to 0.94. Taking into account abnormal camera location during our tests and therefore geometrical distortion and troubles from trees this result could be considered as passable. Correlation between source data, such as license Plate dimensions and texture, cameras location and others, and parameters of algorithm were also defined.

  3. High Speed Edge Detection (United States)

    Prokop, Norman F (Inventor)


    Analog circuits for detecting edges in pixel arrays are disclosed. A comparator may be configured to receive an all pass signal and a low pass signal for a pixel intensity in an array of pixels. A latch may be configured to receive a counter signal and a latching signal from the comparator. The comparator may be configured to send the latching signal to the latch when the all pass signal is below the low pass signal minus an offset. The latch may be configured to hold a last negative edge location when the latching signal is received from the comparator.

  4. Traffic Light Detection

    DEFF Research Database (Denmark)

    Philipsen, Mark Philip; Jensen, Morten Bornø; Møgelmose, Andreas


    Traffic light recognition (TLR) is an integral part of any intelligent vehicle, which must function in the existing infrastructure. Pedestrian and sign detection have recently seen great improvements due to the introduction of learning based detectors using integral channel features. A similar push...... database is collected based on footage from US roads. The database consists of both test and training data, totaling 46,418 frames and 112,971 annotated traffic lights, captured in continuous sequences under a varying light and weather conditions. The learning based detector achieves an AUC of 0.4 and 0...

  5. Visual Concept Detection and Real Time Object Detection

    CERN Document Server

    Tao, Ran


    Bag-of-words model is implemented and tried on 10-class visual concept detection problem. The experimental results show that "DURF+ERT+SVM" outperforms "SIFT+ERT+SVM" both in detection performance and computation efficiency. Besides, combining DURF and SIFT results in even better detection performance. Real-time object detection using SIFT and RANSAC is also tried on simple objects, e.g. drink can, and good result is achieved.

  6. DCA for Bot Detection

    CERN Document Server

    Al-Hammadi, Yousof; Greensmith, Julie


    Ensuring the security of computers is a non-trivial task, with many techniques used by malicious users to compromise these systems. In recent years a new threat has emerged in the form of networks of hijacked zombie machines used to perform complex distributed attacks such as denial of service and to obtain sensitive data such as password information. These zombie machines are said to be infected with a 'bot' - a malicious piece of software which is installed on a host machine and is controlled by a remote attacker, termed the 'botmaster of a botnet'. In this work, we use the biologically inspired Dendritic Cell Algorithm (DCA) to detect the existence of a single bot on a compromised host machine. The DCA is an immune-inspired algorithm based on an abstract model of the behaviour of the dendritic cells of the human body. The basis of anomaly detection performed by the DCA is facilitated using the correlation of behavioural attributes such as keylogging and packet flooding behaviour. The results of the applica...

  7. Distributed Impact Detection System Project (United States)

    National Aeronautics and Space Administration — Automated impact detection and characterization on manned spacecraft has been an elusive goal due to the transitory nature of the detectable high-frequency signals....

  8. Nucleic acid detection system and method for detecting influenza

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Hong; Song, Jian


    The invention provides a rapid, sensitive and specific nucleic acid detection system which utilizes isothermal nucleic acid amplification in combination with a lateral flow chromatographic device, or DNA dipstick, for DNA-hybridization detection. The system of the invention requires no complex instrumentation or electronic hardware, and provides a low cost nucleic acid detection system suitable for highly sensitive pathogen detection. Hybridization to single-stranded DNA amplification products using the system of the invention provides a sensitive and specific means by which assays can be multiplexed for the detection of multiple target sequences.

  9. Novelty Detection Methods and Novel Fault Class Detection

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jiafan; HUANG Zhichu; WANG Xiaoming


    The ability to detect a new fault class can be a useful feature for an intelligent fault classification and diagnosis system. We adopt two novelty detection methods, the support vector data description (SVDD) and the Parzen density estimation, to represent known fault class samples, and to detect new fault class samples. The experiments on real multi-class bearing fault data show that the SVDD can give both high novelty detection rate and target recognition rate, respectively for the prescribed 'unknown' fault samples and the known fault samples by choosing the appropriate SVDD algorithm parameters; but the Parzen density estimation only give a better novelty detection rate in our experiments.

  10. Detection of anomalous events

    Energy Technology Data Exchange (ETDEWEB)

    Ferragut, Erik M.; Laska, Jason A.; Bridges, Robert A.


    A system is described for receiving a stream of events and scoring the events based on anomalousness and maliciousness (or other classification). The system can include a plurality of anomaly detectors that together implement an algorithm to identify low-probability events and detect atypical traffic patterns. The anomaly detector provides for comparability of disparate sources of data (e.g., network flow data and firewall logs.) Additionally, the anomaly detector allows for regulatability, meaning that the algorithm can be user configurable to adjust a number of false alerts. The anomaly detector can be used for a variety of probability density functions, including normal Gaussian distributions, irregular distributions, as well as functions associated with continuous or discrete variables.

  11. Immunological Detection of Arbutin

    Institute of Scientific and Technical Information of China (English)


    The relative molecular mass of Arbutin is small.Both fluorolabeling and radiolabeling may affect its properties and functions.Therefore, the immunoassay of Arbutin was studied.Arbutin was coupled to bovine serum albumin to get the Arbutin-BSA conjugate with high molar ratio of Arbutin to BSA.Two rabbits were injected with the conjugate to develop the anti-Arbutin serum.Ammonium sulfate precipitation and affinity chromatography were used to purify the antibody.Double agar diffusion test and enzyme-linked immunosorbent assay (ELISA) were adopted to identify the antibody titer.The results demonstrated that the purity and activity of the antibody are high.The method proposed is satisfactory for the immunological detection of Arbutin.

  12. Watermark Embedding and Detection

    CERN Document Server

    Zhong, Jidong


    The embedder and the detector (or decoder) are the two most important components of the digital watermarking systems. Thus in this work, we discuss how to design a better embedder and detector (or decoder). I first give a summary of the prospective applications of watermarking technology and major watermarking schemes in the literature. My review on the literature closely centers upon how the side information is exploited at both embedders and detectors. In Chapter 3, I explore the optimum detector or decoder according to a particular probability distribution of the host signals. We found that the performance of both multiplicative and additive spread spectrum schemes depends on the shape parameter of the host signals. For spread spectrum schemes, the performance of the detector or the decoder is reduced by the host interference. Thus I present a new host-interference rejection technique for the multiplicative spread spectrum schemes. Its embedding rule is tailored to the optimum detection or decoding rule. T...

  13. Transient Detection and Classification

    CERN Document Server

    Becker, Andrew C


    I provide an incomplete inventory of the astronomical variability that will be found by next-generation time-domain astronomical surveys. These phenomena span the distance range from near-Earth satellites to the farthest Gamma Ray Bursts. The surveys that detect these transients will issue alerts to the greater astronomical community; this decision process must be extremely robust to avoid a slew of ``false'' alerts, and to maintain the community's trust in the surveys. I review the functionality required of both the surveys and the telescope networks that will be following them up, and the role of VOEvents in this process. Finally, I offer some ideas about object and event classification, which will be explored more thoroughly by other articles in these proceedings.

  14. Silicosis: controversy in detection

    Directory of Open Access Journals (Sweden)

    Diemen Darwin Delgado García


    Full Text Available In many countries, the work of mining, quarrying, construction of tunnels and galleries, abrasive jet cleaning and smelting continue to present significant risks of silica exposure and silicosis epidemics still occur, even in developed countries. Patients with silicosis are particularly susceptible to opportunistic lung infections such as aspergillosis and tuberculosis. Occasionally silicosis is associated with scleroderma, systemic lupus erythematosus, nephritis and cancer. Early detection of silicosis is made by chest X-ray method, being the presence of rounded opacities the main sign of illness. However, no systematic information is available that allows use as a standard method of evaluation because their interpretation remains operator dependent both conventional radiological technique, digital and interpretation of computed tomography with high resolution.

  15. Suicide bomber detection (United States)

    Alexander, Naomi; Callejero, Carlos; Fiore, Franco; Gómez, Ignacio; Gonzalo, Ramón; Enríquez de Luna, Álvaro; Ederra, Iñigo; Palacios, Inés


    The chance of suicide bomber attacks against troops in the Theatre of Operations is currently quite high. Most of the time checkpoints and compound gates are not equipped with the appropriate equipment to screen for potential suicide bombers. The ultimate solution would be to be able to perform stand-off screening under various weather conditions whilst avoiding contact between Force Protection personnel and potential suicide bombers. Radiation in the millimeterwave and the lower Terahertz range, having the useful property of being able to penetrate clothing in addition to fog and rain, makes it a clear candidate for imaging in this situation. A study has been made simulating real case scenarios to test practical detection performance and stand-off distances at a range of frequencies in this band, the results of which will be presented.

  16. Strategies of Life Detection

    CERN Document Server

    Botta, Oliver; Gomez-Elvira, Javier; Javaux, Emmanuelle; Selsis, Franck; Summons, Roger


    The search for life outside the Earth has been one of mankind's most challenging quests. We have reached a level of technology that allows for initial steps toward thorough scientific investigation. The aim of this workshop was to take an interdisciplinary look at the signatures that would be indicative of past or present life on another planet and compare them to biosignatures on Earth. The purpose of the workshop was also to discuss state-of-the-art in-situ instruments that are envisioned to search for these signatures in the exploration of the solar system, as well as the discussion of concepts descriptive of the search for habitable planets around other stars. This book is intended to provide a reference to scientists and instrument developers working in the field of in-situ and remote life detection. It can also be used as an interdisciplinary introduction for students and post-doctoral researchers entering this new and exciting field.

  17. Purge corruption detection

    Energy Technology Data Exchange (ETDEWEB)

    Nankee, R.J. II; Frantz, D.C.; Tamm, J.R.; Gutermuth, T.R.


    This patent describes an adaptive memory cell update method for the detection and correction of a possible purge corruption of the adaptive memory portion of the memory in an internal combustion engine control unit, the adaptive memory portion having purge free cells and normal cells. The method consists of: determining the adaptive memory cells to be used during the adaptive memory cell update by determining if the engine conditions are right to turn the purge system off; if the conditions are right to turn the purge system off, turning the purge system off and using the purge free cells in the adaptive memory cell update; if the conditions are not right to turn the purge system off, turning the purge system on and using the normal cells in the adaptive memory cell update.

  18. Pulsed ELDOR detected NMR (United States)

    Schosseler, P.; Wacker, Th.; Schweiger, A.


    A pulsed EPR method for the determination of small hyperfine interactions in disordered systems is described. A selective preparation pulse of frequency ω mw(1) excites allowed and forbidden transitions, thereby burning spectral holes into the EPR line. The positions of the holes caused by the excitation of forbidden transitions correspond to the nuclear transition frequencies of the spin system. A selective detection pulse of frequency ω mw(2) creates an FID with integrated intensity proportional to the magnetization at frequency ω mw(2). The entire hole pattern is obtained by recording the integrated intensity of the FID while varying the frequency difference Δω mw=ω mw(1)-ω mw(2) step by step.

  19. How mammals detect pheromones. (United States)

    Silvotti, L; Montani, G; Tirindelli, R


    One of the most intriguing discoveries in mammalian pheromone research is the report that a short exposure of women to volatile compounds from sweat can significantly alter their menstrual cycle. This work suggests that specific molecules are produced by women at different stages of the menstrual cycle and that this putative 'pheromonal' blend has effects on the timing of the cycle in women that were briefly exposed to it. What human pheromones are and how they work are not known, however a considerable progress has been made in understanding how other mammals are likely to detect pheromones with the discovery of pheromone receptors. Even though it is proved that pheromones affect human responses, it remains unlikely that similar receptors account for these effects.

  20. Metal Detecting in Denmark

    DEFF Research Database (Denmark)

    Dobat, A.S.


    Since the early 1980s, metal detector surveying conducted by non-professional volunteers (amateur archaeologists) has contributed significantly to archaeological research and heritage practice in Denmark. Metal detecting has always been legal in Denmark, and official stakeholders have from...... the beginning of metal detector archaeology pursued a liberal model, focusing on cooperation and inclusion rather than confrontation and criminalization. Like no other surveying method, the metal detector has contributed to increasing enormously the amount of data and sites from metal-rich periods. Virtually...... all of the spectacular and ground-breaking discoveries of the past decades are owed to metal detectors in the hands of amateur archaeologists. In order to serve as a contribution to the discussion on the upsides and downsides of liberal metal detector archaeology, this article addresses mainly three...

  1. Dark matter detection (United States)

    Baudis, Laura


    More than 80 years after its first postulation in modern form, the existence and distribution of dark matter in our Universe is well established. Dark matter is the gravitational glue that holds together galaxies, galaxy clusters and structures on the largest cosmological scales, and an essential component to explain the observed fluctuations in the cosmic microwave background. Yet its existence is inferred indirectly, through its gravitational influence on luminous matter, and its nature is not known. A viable hypothesis is that dark matter is made of new, elementary particles, with allowed masses and interaction strengths spanning a wide range. Two well-motivated classes of candidates are axions and weakly interacting massive particles (WIMPs), and experimental efforts have now reached sensitivities that allow them to test this hypothesis. Axions, produced non-thermally in the early Universe, can be detected by exploiting their predicted couplings to photons and electrons. WIMPs can be detected directly by looking for their collisions with atomic nuclei ultra-low background detectors, or indirectly, through the observation of their annihilation products such as neutrinos, gamma rays, positrons and antiprotons over the astrophysical background. A complementary method is the production of dark matter particles at colliders such as the Large Hadron Collider, where they could be observed indirectly via missing transverse energy, or via associated particle production. I will review the main experimental efforts to search for dark matter particles, and the existing constraints on the interaction cross sections. I will also discuss future experiments, their complementarity and their ability to measure the properties of these particles.

  2. Early Detection Of Cancer

    Directory of Open Access Journals (Sweden)

    V B Bhatnagar


    Full Text Available Farly detection of cancer is based upon three fundamental assumptions, firstly that the trea'ment of benign and precancerous lesions reduces the incidence of cancer, secondly, that the treatment of in situ cancers is conducive to total cure and thirdly that early diagnosis and management of invasive cancer ensures be.ter survival. When patient seeks medical advice for vague symptoms, which could however be due to a possible malignant tumour at a particular site, the alert clinician should investigate the patient immediately to exclude cancer. At this stage cancer is usually not significantly advanced.Currently the U. I. C. C. (International Union for Cancer Control} is studying the epidemiology of cancers in various countries The importance of this is two folds : Firstly by focussing attention on a section of population vulnerable to a particular cancer an early detection is facilitated Secondly by changing the causative factors responsible to a particular cancer, the incidence of that cancer can be reduced e. g. reduction in lung cancer following campaigns against ciguette smoking and reductioi in breast cancer after campaigns for advocating breast feeding of infants, lowering fat consumption and encouraging self palpation of breast regularly.Indeed early diagnosis of cancer implies diagnosis of cancer in almost a symptomatic stage It involves motiva’ion of the population towards acquisitio : of knowledge, attitude and practice.. Epidemiologies and clinicians should be able to recognise high risk cases exposed to particular neoplasia and knowledge of alarming symptoms should be pro- pogated for wide publicity through common available media and means. Probable cases should have regular clhrcal examination periodically and relevant investigations including radiological, imaging techniques and Bio-Chemical examination should be undertaken as and when desired Suspicious lesions should be investigated by specific tests including smear cytology

  3. Corner Detection of Hand Gesture

    Directory of Open Access Journals (Sweden)

    Lili Zhang


    Full Text Available This paper studies the methods of corner detection of hand gesture, and mainly introduces the orthogonal three-direction chain code (3OT and uses it in corner detection of hand gesture. The study is discussed from four aspects: the techniques used in corner detection, the techniques of Freeman chain code, the main idea of 3OT, the process of corner detection with 3OT and the experiments on corner detectors used for hand gesture images of 26 letters in American Sign Language are described in detail. Experiment results show that the 3OT has well performance with exact corner detection rate and least false corner’s number.

  4. Statistical theory of signal detection

    CERN Document Server

    Helstrom, Carl Wilhelm; Costrell, L; Kandiah, K


    Statistical Theory of Signal Detection, Second Edition provides an elementary introduction to the theory of statistical testing of hypotheses that is related to the detection of signals in radar and communications technology. This book presents a comprehensive survey of digital communication systems. Organized into 11 chapters, this edition begins with an overview of the theory of signal detection and the typical detection problem. This text then examines the goals of the detection system, which are defined through an analogy with the testing of statistical hypotheses. Other chapters consider

  5. Detection Range of Airborne Magnetometers in Magnetic Anomaly Detection

    Directory of Open Access Journals (Sweden)

    Chengjing Li


    Full Text Available Airborne magnetometers are utilized for the small-range search, precise positioning, and identification of the ferromagnetic properties of underwater targets. As an important performance parameter of sensors, the detection range of airborne magnetometers is commonly set as a fixed value in references regardless of the influences of environment noise, target magnetic properties, and platform features in a classical model to detect airborne magnetic anomalies. As a consequence, deviation in detection ability analysis is observed. In this study, a novel detection range model is proposed on the basis of classic detection range models of airborne magnetometers. In this model, probability distribution is applied, and the magnetic properties of targets and the environment noise properties of a moving submarine are considered. The detection range model is also constructed by considering the distribution of the moving submarine during detection. A cell-averaging greatest-of-constant false alarm rate test method is also used to calculate the detection range of the model at a desired false alarm rate. The detection range model is then used to establish typical submarine search probabilistic models. Results show that the model can be used to evaluate not only the effects of ambient magnetic noise but also the moving and geomagnetic features of the target and airborne detection platform. The model can also be utilized to display the actual operating range of sensor systems.

  6. Features Based Text Similarity Detection

    CERN Document Server

    Kent, Chow Kok


    As the Internet help us cross cultural border by providing different information, plagiarism issue is bound to arise. As a result, plagiarism detection becomes more demanding in overcoming this issue. Different plagiarism detection tools have been developed based on various detection techniques. Nowadays, fingerprint matching technique plays an important role in those detection tools. However, in handling some large content articles, there are some weaknesses in fingerprint matching technique especially in space and time consumption issue. In this paper, we propose a new approach to detect plagiarism which integrates the use of fingerprint matching technique with four key features to assist in the detection process. These proposed features are capable to choose the main point or key sentence in the articles to be compared. Those selected sentence will be undergo the fingerprint matching process in order to detect the similarity between the sentences. Hence, time and space usage for the comparison process is r...

  7. Robust fault detection filter design (United States)

    Douglas, Randal Kirk

    The detection filter is a specially tuned linear observer that forms the residual generation part of an analytical redundancy system designed for model-based fault detection and identification. The detection filter has an invariant state subspace structure that produces a residual with known and fixed directional characteristics in response to a known design fault direction. In addition to a parameterization of the detection filter gain, three methods are given for improving performance in the presence of system disturbances, sensor noise, model mismatch and sensitivity to small parameter variations. First, it is shown that by solving a modified algebraic Riccati equation, a stabilizing detection filter gain is found that bounds the H-infinity norm of the transfer matrix from system disturbances and sensor noise to the detection filter residual. Second, a specially chosen expanded-order detection filter is formed with fault detection properties identical to a set of independent reduced-order filters that have no structural constraints. This result is important to the practitioner because the difficult problem of finding a detection filter insensitive to disturbances and sensor noise is converted to the easier problem of finding a set of uncoupled noise insensitive filters. Furthermore, the statistical properties of the reduced-order filter residuals are easier to find than the statistical properties of the structurally constrained detection filter residual. Third, an interpretation of the detection filter as a special case of the dual of the restricted decoupling problem leads to a new detection filter eigenstructure assignment algorithm. The new algorithm places detection filter left eigenvectors, which annihilate the detection spaces, rather than right eigenvectors, which span the detection spaces. This allows for a more flexible observer based fault detection system structure that could not be formulated as a detection filter. Furthermore, the link to the dual

  8. Detecting alternative graph clusterings. (United States)

    Mandala, Supreet; Kumara, Soundar; Yao, Tao


    The problem of graph clustering or community detection has enjoyed a lot of attention in complex networks literature. A quality function, modularity, quantifies the strength of clustering and on maximization yields sensible partitions. However, in most real world networks, there are an exponentially large number of near-optimal partitions with some being very different from each other. Therefore, picking an optimal clustering among the alternatives does not provide complete information about network topology. To tackle this problem, we propose a graph perturbation scheme which can be used to identify an ensemble of near-optimal and diverse clusterings. We establish analytical properties of modularity function under the perturbation which ensures diversity. Our approach is algorithm independent and therefore can leverage any of the existing modularity maximizing algorithms. We numerically show that our methodology can systematically identify very different partitions on several existing data sets. The knowledge of diverse partitions sheds more light into the topological organization and helps gain a more complete understanding of the underlying complex network.

  9. Fracture Detection and Mapping

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, Norman E.; Iovenitti, Joseph L.


    Because the costs of drilling, completing, and testing a well can be extremely high, it is important to develop better tools and methods for locating high permeability zones prior to drilling, and to develop better tools and methods for identifying and characterizing major fracture zones during the drilling and well testing stages. At the recommendation of the LBL Industry Review Panel on Geothermal Reservoir Technology, we organized and convened a one-day workshop this past July to discuss various aspects of DOE's current and planned activities in fracture detection, to review the geothermal industry's near-term and long-term research needs, to determine the priority of those needs, to disseminate to industry the status of research in progress, and to discuss the possibility of future joint research between industry and DOE. In this paper we present a brief overview of the workshop from the perspective of those who participated in it and provided us with written comments to a questionnaire that was distributed.

  10. Fracture detection and mapping

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, N.E.; Iovenitti, J.L.


    Because the costs of drilling, completing, and testing a well can be extremely high, it is important to develop better tools and methods for locating high permeability zones prior to drilling, and to develop better tools and methods for identifying and characterizing major fracture zones during the drilling and well testing stages. At the recommendation of the LBL Industry Review Panel on Geothermal Reservoir Technology, we organized and convened a one-day workshop this past July to discuss various aspects of DOE's current and planned activities in fracture detection, to review the geothermal industry's near-term and long-term research needs, to determine the priority of those needs, to disseminate to industry the status of research in progress, and to discuss the possibility of future joint research between industry and DOE. In this paper we present a brief overview of the workshop from the perspective of those who participated in it and provided us with written comments to a questionnaire that was distributed.

  11. Network intrusion detection

    Institute of Scientific and Technical Information of China (English)

    Oboile Tirelo; YANG Chun-hua


    Nowadays, network computer systems play an increasingly important role in society and economy. They have become the targets of a wide array of malicious attacks that invariably turn into actual intrusions. This is why the computer security has become an essential concern for network administrators. Too often, intrusions wreak havoc inside LANs and the time and cost to repair the damage can grow to extreme proportions. Instead of using passive measures to fix and patch security holes once they have been exploited, it is more effective to adopt a protective approach to intrusions. In addition to the well-established intrusion prevention techniques such as data encryption and message integrity, user authentication and user authorization, as well as the avoidance of security flaws inherent to many off-the-shelf applications, intrusion detection techniques can be viewed as an addition safeguard for network computers. The paper discusses traditional and new security designs, the approach to implementing best-practice security measures and the method to trace the malicious computer attackers.

  12. Detection of pump degradation

    Energy Technology Data Exchange (ETDEWEB)

    Casada, D. [Oak Ridge National Lab., TN (United States)


    There are a variety of stressors that can affect the operation of centrifugal pumps. Although these general stressors are active in essentially all centrifugal pumps, the stressor level and the extent of wear and degradation can vary greatly. Parameters that affect the extent of stressor activity are manifold. In order to assure the long-term operational readiness of a pump, it is important to both understand the nature and magnitude of the specific degradation mechanisms and to monitor the performance of the pump. The most commonly applied method of monitoring the condition of not only pumps, but rotating machinery in general, is vibration analysis. Periodic or continuous special vibration analysis is a cornerstone of most pump monitoring programs. In the nuclear industry, non-spectral vibration monitoring of safety-related pumps is performed in accordance with the ASME code. Pump head and flow rate are also monitored, per code requirements. Although vibration analysis has dominated the condition monitoring field for many years, there are other measures that have been historically used to help understand pump condition; advances in historically applied technologies and developing technologies offer improved monitoring capabilities. The capabilities of several technologies (including vibration analysis, dynamic pressure analysis, and motor power analysis) to detect the presence and magnitude of both stressors and resultant degradation are discussed.

  13. Molecular detection of foodborne pathogens

    DEFF Research Database (Denmark)

    Josefsen, Mathilde Hartmann

    Microbiological Methods (NordVal) in comparative and collaborative trials, and was approved for detection of Campylobacter in chicken neck skin, cloacal swab and boot swab samples. A comparison study on probe chemistries for real-time PCR was performed on locked nucleic acid (LNA), minor groove binder (MGB......Val in comparative and collaborative trials and was approved as an alternative method for detection of Salmonella in chicken neck skin, minced meat and pig carcass swabs. In conclusion, this thesis presents the development and validation of real-time PCR methods for detection of Salmonella and Campylobacter...... for detection and enumeration of Salmonella and Campylobacter are time-consuming and laborious. They lack specificity and do not enable detection of viable but non-culturable (VBNC) bacteria. The focus of the present thesis has been development and validation of PCR-based detection methods for Salmonella...

  14. Novelty detection in dermatological images

    DEFF Research Database (Denmark)

    Maletti, Gabriela Mariel


    The problem of novelty detection is considered for at set of dermatological image data. Different points of view are analyzed in detail. First, novelty detection is treated as a contextual classification problem. Different learning phases can be detected when the sample size is increased....... The detection of the emergence a new class is considered here. A model that estimates the minimal amount of information required to recognize structure in the data as a function of class separability is also proposed. Secondly, texture alteration detection is considered a novelty detection problem....... The possibility of avoiding pattern registration by transforming the data to a space invariant of registration is explored through a canonical analysis tool. Problems of expressing the data in a way they can be compared are also considered here, for instance, pattern registration. An approach for patterns...

  15. Detection statistics in the micromaser

    CERN Document Server

    Johnson, D B; Johnson, David B.


    We present a general method for the derivation of various statistical quantities describing the detection of a beam of atoms emerging from a micromaser. The user of non-normalized conditioned density operators and a linear master equation for the dynamics between detection events is discussed as are the counting statistics, sequence statistics, and waiting time statistics. In particular, we derive expressions for the mean number of successive detections of atoms in one of any two orthogonal states of the two-level atom. We also derive expressions for the mean waiting times between detections. We show that the mean waiting times between de- tections of atoms in like states are equivalent to the mean waiting times calculated from the uncorrelated steady state detection rates, though like atoms are indeed correlated. The mean waiting times between detections of atoms in unlike states exhibit correlations. We evaluate the expressions for various detector efficiencies using numerical integration, reporting re- sul...

  16. A fast meteor detection algorithm (United States)

    Gural, P.


    A low latency meteor detection algorithm for use with fast steering mirrors had been previously developed to track and telescopically follow meteors in real-time (Gural, 2007). It has been rewritten as a generic clustering and tracking software module for meteor detection that meets both the demanding throughput requirements of a Raspberry Pi while also maintaining a high probability of detection. The software interface is generalized to work with various forms of front-end video pre-processing approaches and provides a rich product set of parameterized line detection metrics. Discussion will include the Maximum Temporal Pixel (MTP) compression technique as a fast thresholding option for feeding the detection module, the detection algorithm trade for maximum processing throughput, details on the clustering and tracking methodology, processing products, performance metrics, and a general interface description.

  17. Directional Antineutrino Detection (United States)

    Safdi, B. R.; Suerfu, J.


    We propose the first truly directional antineutrino detector for antineutrinos near the threshold for the inverse beta decay (IBD) of hydrogen, with potential applications including the spatial mapping of geo-neutrinos, searches for stellar antineutrinos, and the monitoring of nuclear reactors. The detector consists of adjacent and separated target and neutron-capture layers. The IBD events, which result in a neutron and a positron, take place in the target layers. These layers are thin enough so that the neutrons escape without scattering elastically. The neutrons are detected in the thicker neutron-capture layers. The location of the IBD event is determined from the energy deposited by the positron as it slows in the medium and from the two gamma rays that come from the positron annihilation. Since the neutron recoils in the direction of the antineutrino's motion, a line may then be drawn between the IBD event location and the neutron-capture location to approximate the antineutrino's velocity. In some events, we may even measure the positron's velocity, which further increases our ability to reconstruct the antineutrino's direction of motion. Our method significantly improves upon previous methods by allowing the neutron to freely travel a long distance before diffusing and being captured. Moreover, our design is a straightforward modification of existing antineutrino detectors; a prototype could easily be built with existing technology. We verify our design through Monte Carlo simulations in Geant4, using commercially-available boron-loaded plastic scintillators for the target and neutron-capture layer materials. We are able to discriminate from background using multiple coincidence signatures within a short, ~microsecond time interval. We conclude that the detector could likely operate above ground with minimal shielding.

  18. Nanosensors for trace explosive detection



    Selective and sensitive detection of explosives is very important in countering terrorist threats. Detecting trace explosives has become a very complex and expensive endeavor because of a number of factors, such as the wide variety of materials that can be used as explosives, the lack of easily detectable signatures, the vast number of avenues by which these weapons can be deployed, and the lack of inexpensive sensors with high sensitivity and selectivity. High sensitivity and selectivity, co...

  19. Automatic Sarcasm Detection: A Survey


    Joshi, Aditya; Bhattacharyya, Pushpak; Carman, Mark James


    Automatic sarcasm detection is the task of predicting sarcasm in text. This is a crucial step to sentiment analysis, considering prevalence and challenges of sarcasm in sentiment-bearing text. Beginning with an approach that used speech-based features, sarcasm detection has witnessed great interest from the sentiment analysis community. This paper is the first known compilation of past work in automatic sarcasm detection. We observe three milestones in the research so far: semi-supervised pat...

  20. Detection of signals in noise

    CERN Document Server

    McDonough, Robert N


    The Second Edition is an updated revision to the authors highly successful and widely used introduction to the principles and application of the statistical theory of signal detection. This book emphasizes those theories that have been found to be particularly useful in practice including principles applied to detection problems encountered in digital communications, radar, and sonar.Detection processing based upon the fast Fourier transform

  1. Materials science for nuclear detection

    Directory of Open Access Journals (Sweden)

    Anthony Peurrung


    Full Text Available The increasing importance of nuclear detection technology has led to a variety of research efforts that seek to accelerate the discovery and development of useful new radiation detection materials. These efforts aim to improve our understanding of how these materials perform, develop formalized discovery tools, and enable rapid and effective performance characterization. We provide an overview of these efforts along with an introduction to the history, physics, and taxonomy of radiation detection materials.

  2. Theoretically Optimal Distributed Anomaly Detection (United States)

    National Aeronautics and Space Administration — A novel general framework for distributed anomaly detection with theoretical performance guarantees is proposed. Our algorithmic approach combines existing anomaly...

  3. Detection of signals in noise

    CERN Document Server

    Whalen, Anthony D; Declaris, Nicholas


    Detection of Signals in Noise serves as an introduction to the principles and applications of the statistical theory of signal detection. The book discusses probability and random processes; narrowband signals, their complex representation, and their properties described with the aid of the Hilbert transform; and Gaussian-derived processes. The text also describes the application of hypothesis testing for the detection of signals and the fundamentals required for statistical detection of signals in noise. Problem exercises, references, and a supplementary bibliography are included after each c

  4. Adaptive filtering and change detection

    CERN Document Server

    Gustafsson, Fredrik


    Adaptive filtering is a classical branch of digital signal processing (DSP). Industrial interest in adaptive filtering grows continuously with the increase in computer performance that allows ever more conplex algorithms to be run in real-time. Change detection is a type of adaptive filtering for non-stationary signals and is also the basic tool in fault detection and diagnosis. Often considered as separate subjects Adaptive Filtering and Change Detection bridges a gap in the literature with a unified treatment of these areas, emphasizing that change detection is a natural extensi

  5. Novel Model for Intrusion Detection

    Institute of Scientific and Technical Information of China (English)

    Li Jia-chun; Li Zhi-tang


    It's very difficult that the traditional intrusion detection methods based on accurate match adapt to the blur and uncertainty of user information and expert knowledge, it results in failing to report the variations of attack signature. In addition security itself includes fuzziness, the judgment standard of confidentiality, integrity and availability of system resource is uncertain. In this paper fuzzy intrusion detection based on partial match is presented to detect some types of attacks availably and alleviate some of the difficulties of above approaches, the architecture of fuzzy intrusion detection system(FIDS) is introduced and its performance is analyzed.

  6. Novel Model for Intrusion Detection

    Institute of Scientific and Technical Information of China (English)

    Li; Jia-chun; Li; Zhi-tang


    It's very difficult that the traditional intrusion detection methods based on accurate match adapt to the blur and uncertainty of user information and expert knowledge, it results in failing to report the variation of attack signature.In addition security itself includes fuzziness, the judgment standard of confidentiality, integrity and availability of system resource is uncertain. In this paper fuzzy intrusion detection based on partial match is presented to detect some types of attacks availably and alleviate some of the difficulties of above approaches, the architecture of fuzzy intrusion detection system(FIDS) is introduced and its performance is analyzed.

  7. Fusion of Heterogeneous Intrusion Detection Systems for Network Attack Detection

    Directory of Open Access Journals (Sweden)

    Jayakumar Kaliappan


    Full Text Available An intrusion detection system (IDS helps to identify different types of attacks in general, and the detection rate will be higher for some specific category of attacks. This paper is designed on the idea that each IDS is efficient in detecting a specific type of attack. In proposed Multiple IDS Unit (MIU, there are five IDS units, and each IDS follows a unique algorithm to detect attacks. The feature selection is done with the help of genetic algorithm. The selected features of the input traffic are passed on to the MIU for processing. The decision from each IDS is termed as local decision. The fusion unit inside the MIU processes all the local decisions with the help of majority voting rule and makes the final decision. The proposed system shows a very good improvement in detection rate and reduces the false alarm rate.

  8. MPI Runtime Error Detection with MUST: Advances in Deadlock Detection

    Directory of Open Access Journals (Sweden)

    Tobias Hilbrich


    Full Text Available The widely used Message Passing Interface (MPI is complex and rich. As a result, application developers require automated tools to avoid and to detect MPI programming errors. We present the Marmot Umpire Scalable Tool (MUST that detects such errors with significantly increased scalability. We present improvements to our graph-based deadlock detection approach for MPI, which cover future MPI extensions. Our enhancements also check complex MPI constructs that no previous graph-based detection approach handled correctly. Finally, we present optimizations for the processing of MPI operations that reduce runtime deadlock detection overheads. Existing approaches often require (p analysis time per MPI operation, for p processes. We empirically observe that our improvements lead to sub-linear or better analysis time per operation for a wide range of real world applications.

  9. Detecting suicidality on Twitter

    Directory of Open Access Journals (Sweden)

    Bridianne O'Dea


    Full Text Available Twitter is increasingly investigated as a means of detecting mental health status, including depression and suicidality, in the population. However, validated and reliable methods are not yet fully established. This study aimed to examine whether the level of concern for a suicide-related post on Twitter could be determined based solely on the content of the post, as judged by human coders and then replicated by machine learning. From 18th February 2014 to 23rd April 2014, Twitter was monitored for a series of suicide-related phrases and terms using the public Application Program Interface (API. Matching tweets were stored in a data annotation tool developed by the Commonwealth Scientific and Industrial Research Organisation (CSIRO. During this time, 14,701 suicide-related tweets were collected: 14% were randomly (n = 2000 selected and divided into two equal sets (Set A and B for coding by human researchers. Overall, 14% of suicide-related tweets were classified as ‘strongly concerning’, with the majority coded as ‘possibly concerning’ (56% and the remainder (29% considered ‘safe to ignore’. The overall agreement rate among the human coders was 76% (average κ = 0.55. Machine learning processes were subsequently applied to assess whether a ‘strongly concerning’ tweet could be identified automatically. The computer classifier correctly identified 80% of ‘strongly concerning’ tweets and showed increasing gains in accuracy; however, future improvements are necessary as a plateau was not reached as the amount of data increased. The current study demonstrated that it is possible to distinguish the level of concern among suicide-related tweets, using both human coders and an automatic machine classifier. Importantly, the machine classifier replicated the accuracy of the human coders. The findings confirmed that Twitter is used by individuals to express suicidality and that such posts evoked a level of concern that warranted

  10. Instruments for Methane Gas Detection

    Directory of Open Access Journals (Sweden)

    Mr. Sibu Thomas


    Full Text Available This paper gives the explanation of different instruments for detecting methane gas in detail. This paper discusses their working principles. Methane gas detection is essentially required in the areas like in coal mines, power plant, Waste Water Treatment, Boiler Rooms etc. This paper also discusses their roles in various applications.

  11. Surface Detection using Round Cut

    DEFF Research Database (Denmark)

    Dahl, Vedrana Andersen; Dahl, Anders Bjorholm; Larsen, Rasmus


    We propose an iterative method for detecting closed surfaces in a volumetric data, where an optimal search is performed in a graph build upon a triangular mesh. Our approach is based on previous techniques for detecting an optimal terrain-like or tubular surface employing a regular grid. Unlike s...

  12. Detection of COPD in smokers

    NARCIS (Netherlands)

    Geijer, R.M.M.


    Smoking is the main risk factor for Chronic Obstructive Pulmonary Disease (COPD), formerly known as lung emphysema or ‘chronic bronchitis’. Early detection of COPD and smoking cessation may result in significant health gain. In a thesis titled ‘Detection of COPD in smokers’ the results of 6 studies

  13. Learning to Detect Traffic Signs

    DEFF Research Database (Denmark)

    Møgelmose, Andreas; Trivedi, Mohan M.; Moeslund, Thomas B.


    This study compares the performance of sign detection based on synthetic training data to the performance of detection based on real-world training images. Viola-Jones detectors are created for 4 different traffic signs with both synthetic and real data, and varying numbers of training samples. T...

  14. Candida infections : detection and epidemiology

    NARCIS (Netherlands)

    Borst, A. (Annemarie)


    Despite the fact that the yeast Candida is the number 4 cause of bloodstream infections in the United States and ranks number 8 in Europe, adequate detection methods are lacking. Furthermore, relatively little is known about the epidemiology of Candida. Our aim was to improve the detection and ident

  15. Putting sarcasm detection into context

    DEFF Research Database (Denmark)

    Abercrombie, Gavin; Hovy, Dirk


    Sarcasm can radically alter or invert a phrase's meaning. Sarcasm detection can therefore help improve natural language processing (NLP) tasks. However, the majority of prior research has treated sarcasm detection as classification, with three important limitations: 1. Balanced datasets, when sar...

  16. Calculations for cosmic axion detection (United States)

    Krauss, L.; Moody, J.; Wilczek, F.; Morris, D. E.


    Calculations are presented, using properly nomalized couplings and masses for Dine-Fischler-Srednicki axions, of power rates and signal temperatures for axion-photon conversion in microwave cavities. The importance of the galactic-halo axion line shape is emphasized. Spin-coupled detection as an alternative to magnetic-field-coupled detection is mentioned.

  17. The history of exoplanet detection. (United States)

    Perryman, Michael


    I summarize the early developments of the more quantitative aspects of exoplanet detection. After a brief overview of the observational methods currently applied to exoplanet searches and a summary of the first true exoplanet detections resulting from these various techniques, the more relevant historical background is organized according to the observational techniques that are currently most relevant.

  18. Technology improves CBRNE response, detection



    Center for Homeland Defense and Security, OUT OF THE CLASSROOM The Washington, D.C. Metropolitan Police Department uses numerous programs designed to assist in the detection and response to Chemical-Biological-Radiological-Nuclear and Explosive (CBRNE incidents). These programs include deployment of detection and...

  19. Change detection in satellite images (United States)

    Thonnessen, U.; Hofele, G.; Middelmann, W.


    Change detection plays an important role in different military areas as strategic reconnaissance, verification of armament and disarmament control and damage assessment. It is the process of identifying differences in the state of an object or phenomenon by observing it at different times. The availability of spaceborne reconnaissance systems with high spatial resolution, multi spectral capabilities, and short revisit times offer new perspectives for change detection. Before performing any kind of change detection it is necessary to separate changes of interest from changes caused by differences in data acquisition parameters. In these cases it is necessary to perform a pre-processing to correct the data or to normalize it. Image registration and, corresponding to this task, the ortho-rectification of the image data is a further prerequisite for change detection. If feasible, a 1-to-1 geometric correspondence should be aspired for. Change detection on an iconic level with a succeeding interpretation of the changes by the observer is often proposed; nevertheless an automatic knowledge-based analysis delivering the interpretation of the changes on a semantic level should be the aim of the future. We present first results of change detection on a structural level concerning urban areas. After pre-processing, the images are segmented in areas of interest and structural analysis is applied to these regions to extract descriptions of urban infrastructure like buildings, roads and tanks of refineries. These descriptions are matched to detect changes and similarities.

  20. Robust Adaptable Video Copy Detection

    DEFF Research Database (Denmark)

    Assent, Ira; Kremer, Hardy


    Video copy detection should be capable of identifying video copies subject to alterations e.g. in video contrast or frame rates. We propose a video copy detection scheme that allows for adaptable detection of videos that are altered temporally (e.g. frame rate change) and/or visually (e.g. change...... in contrast). Our query processing combines filtering and indexing structures for efficient multistep computation of video copies under this model. We show that our model successfully identifies altered video copies and does so more reliably than existing models....


    Directory of Open Access Journals (Sweden)

    S. V. Bibikov


    Full Text Available The paper deals with detection algorithm for rail vibroacoustic waves caused by approaching train on the background of increased noise. The urgency of algorithm development for train detection in view of increased rail noise, when railway lines are close to roads or road intersections is justified. The algorithm is based on the method of weak signals detection in a noisy environment. The information statistics ultimate expression is adjusted. We present the results of algorithm research and testing of the train approach alarm device that implements the proposed algorithm. The algorithm is prepared for upgrading the train approach alarm device “Signalizator-P".


    Directory of Open Access Journals (Sweden)

    Kazi Tanvir Ahmed Siddiqui


    Full Text Available The increasing popularity of animes makes it vulnerable to unwanted usages like copyright violations and pornography. That’s why, we need to develop a method to detect and recognize animation characters. Skin detection is one of the most important steps in this way. Though there are some methods to detect human skin color, but those methods do not work properly for anime characters. Anime skin varies greatly from human skin in color, texture, tone and in different kinds of lighting. They also vary greatly among themselves. Moreover, many other things (for example leather, shirt, hair etc., which are not skin, can have color similar to skin. In this paper, we have proposed three methods that can identify an anime character’s skin more successfully as compared with Kovac, Swift, Saleh and Osman methods, which are primarily designed for human skin detection. Our methods are based on RGB values and their comparative relations.

  3. Hydrocarbon Leak Detection Sensor Project (United States)

    National Aeronautics and Space Administration — FTT is proposing the development of a sensor to detect the presence of hydrocarbons in turbopump Inter-Propellant Seals (IPS). The purpose of the IPS is to prevent...

  4. Marfan's Syndrome: Detection and Management. (United States)

    Cantwell, John D.


    Marfan's Syndrome, a disorder of connective tissue, has gained increased attention since the death of volleyball star Flo Hyman. This article reviews the disease and discusses methods of detection and management. (Author/MT)

  5. Method for detecting biological toxins

    Energy Technology Data Exchange (ETDEWEB)

    Ligler, F.S.; Campbell, J.R.


    Biological toxins are indirectly detected by using polymerase chain reaction to amplify unique nucleic acid sequences coding for the toxins or enzymes unique to toxin synthesis. Buffer, primers coding for the unique nucleic acid sequences and an amplifying enzyme are added to a sample suspected of containing the toxin. The mixture is then cycled thermally to exponentially amplify any of these unique nucleic acid sequences present in the sample. The amplified sequences can be detected by various means, including fluorescence. Detection of the amplified sequences is indicative of the presence of toxin in the original sample. By using more than one set of labeled primers, the method can be used to simultaneously detect several toxins in a sample.

  6. Nanotechnology for Early Cancer Detection

    Directory of Open Access Journals (Sweden)

    Joon Won Park


    Full Text Available Vast numbers of studies and developments in the nanotechnology area have been conducted and many nanomaterials have been utilized to detect cancers at early stages. Nanomaterials have unique physical, optical and electrical properties that have proven to be very useful in sensing. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon nanotubes, gold nanowires and many other materials have been developed over the years, alongside the discovery of a wide range of biomarkers to lower the detection limit of cancer biomarkers. Proteins, antibody fragments, DNA fragments, and RNA fragments are the base of cancer biomarkers and have been used as targets in cancer detection and monitoring. It is highly anticipated that in the near future, we might be able to detect cancer at a very early stage, providing a much higher chance of treatment.

  7. Mystery in Sepedi detective stories

    Directory of Open Access Journals (Sweden)

    M.J. Mojalefa


    Full Text Available The aim of this article is to illustrate the importance of the concept “mystery” in the classification of Sepedi detective stories. Mystery is therefore first defined, and then some rules governing how mystery is created and sustained in a narrative are reviewed. Examples are given of how the writers of Sepedi detective stories mislead their readers in order to create mystery. Mystery is then examined according to five of its constituent elements, namely the real character of the detective, the name of the criminal, the identity of the victim, the evidence that reveals the mystery in the end, and the investigation that reveals the mystery. Each category is explored by citing relevant examples from Sepedi detective stories.

  8. Detection of precessing circumpulsar disks

    CERN Document Server

    Grimani, C


    Experimental evidences indicate that formations of disks and planetary systems around pulsars are allowed. Unfortunately, direct detections through electromagnetic observations appear to be quite rare. In the case of PSR 1931+24, the hypothesis of a rigid precessing disk penetrating the pulsar light cylinder is found consistent with radio transient observations from this star. Disk self-occultation and precession may limit electromagnetic observations. Conversely, we show here that gravitational waves generated by disk precessing near the light cylinder of young and middle aged pulsars would be detected by future space interferometers with sensitivities like those expected for DECIGO (DECI-hertz Interferometer Gravitational Wave Observatory) and BBO (Big Bang Observer). The characteristics of circumpulsar detectable precessing disks are estimated as a function of distance from the Solar System. Speculations on upper limits to detection rates are presented.

  9. Separating detection and catalog production

    CERN Document Server

    Akhlaghi, Mohammad


    In the coming era of massive surveys (e.g. LSST, SKA), the role of the database designers and the algorithms they choose to adopt becomes the decisive factor in scientific progress. Systems that allow/encourage users/scientists to be more creative with the reduction/analysis algorithms can greatly enhance scientific productivity. The separation/modularity of the detection processes and catalog production is one proposal for achieving `Reduction/analysis algorithms for large databases and vice versa' (a key theme for the 26th ADASS). With the new noise-based detection paradigm, non-parametric detection is now possible for astronomical objects to very low surface brightness limits. In our implementation, one software (NoiseChisel) is in charge of detection and another (MakeCatalog) is in charge of catalog production. This modularity has many advantages for pipeline developers, and more importantly, it empowers scientific curiosity and creativity.

  10. Trends In Android Malware Detection

    Directory of Open Access Journals (Sweden)

    Kaveh Shaerpour


    Full Text Available This paper analyzes different Android malware detection techniques from several research papers, some of these techniques are novel while others bring a new perspective to the research work done in the past. The techniques are of various kinds ranging from detection using host based frameworks and static analysis of executable to feature extraction and behavioral patterns. Each paper is reviewed extensively and the core features of each technique are highlighted and contrasted with the others. The challenges faced during the development of such techniques are also discussed along with the future prospects for Android malware detection. The findings of the review have been well documented in this paper to aid those making an effort to research in the area of Android malware detection by understanding the current scenario and developments that have happened in the field thus far.

  11. Detecting coherent structures using braids

    CERN Document Server

    Allshouse, Michael R


    The detection of coherent structures is an important problem in fluid dynamics, particularly in geophysical applications. For instance, knowledge of how regions of fluid are isolated from each other allows prediction of the ultimate fate of oil spills. Existing methods detect Lagrangian coherent structures, which are barriers to transport, by examining the stretching field as given by finite-time Lyapunov exponents. These methods are very effective when the velocity field is well-determined, but in many applications only a small number of flow trajectories are known, for example when dealing with oceanic float data. We introduce a topological method for detecting invariant regions based on a small set of trajectories. In the method we regard the two-dimensional trajectory data as a braid in three dimensions, with time being the third coordinate. Invariant regions then correspond to trajectories that travel together and do not entangle other trajectories. We detect these regions by examining the growth of hypo...

  12. Detection of interstellar $CH_{3}$

    CERN Document Server

    Feuchtgruber, H; Van Dishoeck, E F; Wright, C M


    Observations with the Short Wavelength Spectrometer (SWS) onboard the {\\it Infrared Space Observatory} (ISO) have led to the first detection of the methyl radical ${\\rm CH_3}$ in the interstellar medium. The $\

  13. Recent advances in mycotoxins detection. (United States)

    Chauhan, Ruchika; Singh, Jay; Sachdev, Tushar; Basu, T; Malhotra, B D


    Mycotoxins contamination in both food and feed is inevitable. Mycotoxin toxicity in foodstuff can occur at very low concentrations necessitating early availability of sensitive and reliable methods for their detection. The present research thrust is towards the development of a user friendly biosensor for mycotoxin detection at both academic and industrial levels to replace conventional expensive chromatographic and ELISA techniques. This review critically analyzes the recent research trend towards the construction of immunosensor, aptasensor, enzymatic sensors and others for mycotoxin detection with a reference to label and label free methods, synthesis of new materials including nano dimension, and transuding techniques. Technological aspects in the development of biosensors for mycotoxin detection, current challenges and future prospects are also included to provide a overview and suggestions for future research directions.

  14. Standoff Detection Technology Evaluation Facility (United States)

    Federal Laboratory Consortium — The Standoff Detection Technology Evaluation facility is the only one of its kind in the country and allows researchers to release a known amount of material while...

  15. Detecting Stochastic Information of Electrocardiograms

    CERN Document Server

    Gutíerrez, R M; Guti'errez, Rafael M.; Sandoval, Luis A.


    In this work we present a method to detect, identify and characterize stochastic information contained in an electrocardiogram (ECG). We assume, as it is well known, that the ECG has information corresponding to many different processes related to the cardiac activity. We analyze scaling and Markov processes properties of the detected stochastic information using the power spectrum of the ECG and the Fokker-Planck equation respectively. The detected stochastic information is then characterized by three measures. First, the slope of the power spectrum in a particular range of frequencies as a scaling parameter. Second, an empirical estimation of the drift and diffusion coefficients of the Fokker-Planck equation through the Kramers-Moyal coefficients which define the evolution of the probability distribution of the detected stochastic information.

  16. Measurement and detection of radiation

    CERN Document Server

    Tsoulfanidis, Nicholas


    This is an update of the standard textbook for the field of radiation measurement. It includes illustrative examples and new problems. The research and applications of nuclear instrumentation have grown substantially since publication of the previous editions. With the miniaturization of equipment, increased speed of electronic components, and more sophisticated software, radiation detection systems are now more productively used in many disciplines, including nuclear nonproliferation, homeland security, and nuclear medicine. Continuing in the tradition of its bestselling predecessors, "Measurement and Detection of Radiation, Third Edition" illustrates the fundamentals of nuclear interactions and radiation detection with a multitude of examples and problems. It offers a clearly written, accessible introduction to nuclear instrumentation concepts. The following are new to the third edition: a new chapter on the latest applications of radiation detection, covering nuclear medicine, dosimetry, health physics, no...

  17. Detection of Life Forms Project (United States)

    National Aeronautics and Space Administration — Gaia Genomics proposes to develop an instrument for the detection of earthborn and/or planetary life forms that are based on a nucleic acid paradigm. Highly...

  18. Dendritic Cells for Anomaly Detection

    CERN Document Server

    Greensmith, Julie; Aickelin, Uwe


    Artificial immune systems, more specifically the negative selection algorithm, have previously been applied to intrusion detection. The aim of this research is to develop an intrusion detection system based on a novel concept in immunology, the Danger Theory. Dendritic Cells (DCs) are antigen presenting cells and key to the activation of the human signals from the host tissue and correlate these signals with proteins know as antigens. In algorithmic terms, individual DCs perform multi-sensor data fusion based on time-windows. The whole population of DCs asynchronously correlates the fused signals with a secondary data stream. The behaviour of human DCs is abstracted to form the DC Algorithm (DCA), which is implemented using an immune inspired framework, libtissue. This system is used to detect context switching for a basic machine learning dataset and to detect outgoing portscans in real-time. Experimental results show a significant difference between an outgoing portscan and normal traffic.

  19. The Detectability of Orphan Afterglows

    CERN Document Server

    Piran, E N T


    The realization that GRBs release a rather constant amount of energy implies that the post jet-break afterglow evolution would be rather universal and for a given redshift they should be detected up to a fixed observer angle. We estimate the observed magnitude and the implied detectability of orphan afterglows. We show that orphan afterglows would be detectable only up to rather small ($\\sim 10^o$) angles away from the GRB jet axis. Thus a detection orphan afterglow would generally correspond to a "near-miss" of the GRB whose jet was pointing just slightly away from us. Both theoretical and phenomenological estimates of the rate of orphan afterglows suffer from a rather large uncertainty. With our "canonical" parameters we expect a dozen transients that would arise from orphan GRBs in the SDSS and a comparable number of transients in a dedicated 2M class telescope operating full time in an orphan afterglow search.

  20. Kernel Rootkits Implement and Detection

    Institute of Scientific and Technical Information of China (English)

    LI Xianghe; ZHANG Liancheng; LI Shuo


    Rootkits, which unnoticeably reside in your computer, stealthily carry on remote control and software eavesdropping, are a great threat to network and computer security. It' time to acquaint ourselves with their implement and detection. This article pays more attention to kernel rootkits, because they are more difficult to compose and to be identified than useland rootkits. The latest technologies used to write and detect kernel rootkits, along with their advantages and disadvantages, are present in this article.

  1. Machine Learning Based Malware Detection (United States)


    A TRIDENT SCHOLAR PROJECT REPORT NO. 440 Machine Learning Based Malware Detection by Midshipman 1/C Zane A. Markel, USN...public release and sale; its distribution is limited. U.S.N.A. --- Trident Scholar project report; no. 440 (2015) MACHINE LEARNING BASED MALWARE...COVERED (From - To) 4. TITLE AND SUBTITLE Machine Learning Based Malware Detection 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM

  2. Trace Explosives Detection by Photoluminescence



    Some field tests in counter-terrorism efforts to detect explosive traces employ chemistries that yield colored products. We have examined a test kit of this kind, ETKPlus, based on widely used chemistries and employed extensively by the Israel Police. Our investigation focuses on the prospect of gaining sensitivity by replacing the normal colorimetric modality with photoluminescence detection, which, to our knowledge, has not been explored to date. We find two or more orders of magnitude sens...

  3. Local method for detecting communities (United States)

    Bagrow, James P.; Bollt, Erik M.


    We propose a method of community detection that is computationally inexpensive and possesses physical significance to a member of a social network. This method is unlike many divisive and agglomerative techniques and is local in the sense that a community can be detected within a network without requiring knowledge of the entire network. A global application of this method is also introduced. Several artificial and real-world networks, including the famous Zachary karate club, are analyzed.

  4. Event Detection by Velocity Pyramid



    In this paper, we propose velocity pyramid for multimediaevent detection. Recently, spatial pyramid matching is proposed to in-troduce coarse geometric information into Bag of Features framework,and is eective for static image recognition and detection. In video, notonly spatial information but also temporal information, which repre-sents its dynamic nature, is important. In order to fully utilize it, wepropose velocity pyramid where video frames are divided into motionalsub-regions. Our meth...

  5. A Voltage Quality Detection Method

    DEFF Research Database (Denmark)

    Chen, Zhe; Wei, Mu


    This paper presents a voltage quality detection method based on a phase-locked loop (PLL) technique. The technique can detect the voltage magnitude and phase angle of each individual phase under both normal and fault power system conditions. The proposed method has the potential to evaluate various...... power quality disturbances, such as interruptions, sags and imbalances. Simulation studies have been performed. The effectiveness of the proposed method has been demonstrated under the simulated typical power disturbances....

  6. Mine Safety Detection System (MSDS) (United States)


    BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS Acronym Term ALMDS Airborne Laser -Mine Detection System AMCM Airborne Mine Countermeasure AoA...Streak Tube Imaging Laser ULCC Ultra Large Crude Carrier USN United States Navy UWIED Under Water Improvised Explosive Devices VLCC Very Large sonar, passive sonar, infra-red (IR) thermal imaging, LIDAR (Light Detection and Ranging), and the use of marine mammals ( dolphins and porpoises

  7. Detection of landmines (Review Paper

    Directory of Open Access Journals (Sweden)

    A.K. Sinha


    Full Text Available Detection of landmines is a problem concerning both military and peacekeeping forces. This paper reviews literature on strategic minefield layouts, modern mine clearing, and mine countermeasure techniques based on mechanical methods. Discusses hydraulic and signal processing techniques, ion-trap mobility spectrometer, subsurface probing radar and few other novel methods employed for this purpose. The specialised directions that the landmine detection methods are taking are clearly pointed out.

  8. Accounting fraud detection and prevention




    The purpose, of my thesis, was to extend results of my previous thesis concerning ethics in accounting. Mainly in the field of accounting fraud detection and prevention. First, I referred to ethics in accounting, financial fraud, risks resulting from its insufficient sentencing and specific types of fraud. Secondly, I described methods of accounting fraud detection and prevention. Among others internal audit, whistleblowing, software, preventive controls, confirmation of work history and educ...

  9. Ferromagnetic Objects Magnetovision Detection System

    Directory of Open Access Journals (Sweden)

    Michał Nowicki


    Full Text Available This paper presents the application of a weak magnetic fields magnetovision scanning system for detection of dangerous ferromagnetic objects. A measurement system was developed and built to study the magnetic field vector distributions. The measurements of the Earth’s field distortions caused by various ferromagnetic objects were carried out. The ability for passive detection of hidden or buried dangerous objects and the determination of their location was demonstrated.

  10. Photoacoustic Spectroscopy for Chemical Detection (United States)


    Photoacoustic Spectroscopy for Chemical Detection by Ellen L. Holthoff and Paul M. Pellegrino ARL-RP-0410 September 2012...Laboratory Adelphi, MD 20783-1197 ARL-RP-0410 September 2012 Photoacoustic Spectroscopy for Chemical Detection Ellen L. Holthoff and Paul M...ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) September 2012 2. REPORT TYPE 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Photoacoustic

  11. Seismic data fusion anomaly detection (United States)

    Harrity, Kyle; Blasch, Erik; Alford, Mark; Ezekiel, Soundararajan; Ferris, David


    Detecting anomalies in non-stationary signals has valuable applications in many fields including medicine and meteorology. These include uses such as identifying possible heart conditions from an Electrocardiography (ECG) signals or predicting earthquakes via seismographic data. Over the many choices of anomaly detection algorithms, it is important to compare possible methods. In this paper, we examine and compare two approaches to anomaly detection and see how data fusion methods may improve performance. The first approach involves using an artificial neural network (ANN) to detect anomalies in a wavelet de-noised signal. The other method uses a perspective neural network (PNN) to analyze an arbitrary number of "perspectives" or transformations of the observed signal for anomalies. Possible perspectives may include wavelet de-noising, Fourier transform, peak-filtering, etc.. In order to evaluate these techniques via signal fusion metrics, we must apply signal preprocessing techniques such as de-noising methods to the original signal and then use a neural network to find anomalies in the generated signal. From this secondary result it is possible to use data fusion techniques that can be evaluated via existing data fusion metrics for single and multiple perspectives. The result will show which anomaly detection method, according to the metrics, is better suited overall for anomaly detection applications. The method used in this study could be applied to compare other signal processing algorithms.

  12. Hanle Detection for Optical Clocks

    Directory of Open Access Journals (Sweden)

    Xiaogang Zhang


    Full Text Available Considering the strong inhomogeneous spatial polarization and intensity distribution of spontaneous decay fluorescence due to the Hanle effect, we propose and demonstrate a universe Hanle detection configuration of electron-shelving method for optical clocks. Experimental results from Ca atomic beam optical frequency standard with electron-shelving method show that a designed Hanle detection geometry with optimized magnetic field direction, detection laser beam propagation and polarization direction, and detector position can improve the fluorescence collection rate by more than one order of magnitude comparing with that of inefficient geometry. With the fixed 423 nm fluorescence, the improved 657 nm optical frequency standard signal intensity is presented. The potential application of the Hanle detection geometry designed for facilitating the fluorescence collection for optical lattice clock with a limited solid angle of the fluorescence collection has been discussed. The Hanle detection geometry is also effective for ion detection in ion optical clock and quantum information experiments. Besides, a cylinder fluorescence collection structure is designed to increase the solid angle of the fluorescence collection in Ca atomic beam optical frequency standard.

  13. Multi-Sensor Mud Detection (United States)

    Rankin, Arturo L.; Matthies, Larry H.


    Robust mud detection is a critical perception requirement for Unmanned Ground Vehicle (UGV) autonomous offroad navigation. A military UGV stuck in a mud body during a mission may have to be sacrificed or rescued, both of which are unattractive options. There are several characteristics of mud that may be detectable with appropriate UGV-mounted sensors. For example, mud only occurs on the ground surface, is cooler than surrounding dry soil during the daytime under nominal weather conditions, is generally darker than surrounding dry soil in visible imagery, and is highly polarized. However, none of these cues are definitive on their own. Dry soil also occurs on the ground surface, shadows, snow, ice, and water can also be cooler than surrounding dry soil, shadows are also darker than surrounding dry soil in visible imagery, and cars, water, and some vegetation are also highly polarized. Shadows, snow, ice, water, cars, and vegetation can all be disambiguated from mud by using a suite of sensors that span multiple bands in the electromagnetic spectrum. Because there are military operations when it is imperative for UGV's to operate without emitting strong, detectable electromagnetic signals, passive sensors are desirable. JPL has developed a daytime mud detection capability using multiple passive imaging sensors. Cues for mud from multiple passive imaging sensors are fused into a single mud detection image using a rule base, and the resultant mud detection is localized in a terrain map using range data generated from a stereo pair of color cameras.

  14. Detecting true lies: police officers' ability to detect suspects' lies. (United States)

    Mann, Samantha; Vrij, Aldert; Bull, Ray


    Ninety-nine police officers, not identified in previous research as belonging to groups that are superior in lie detection, attempted to detect truths and lies told by suspects during their videotaped police interviews. Accuracy rates were higher than those typically found in deception research and reached levels similar to those obtained by specialized lie detectors in previous research. Accuracy was positively correlated with perceived experience in interviewing suspects and with mentioning cues to detecting deceit that relate to a suspect's story. Accuracy was negatively correlated with popular stereotypical cues such as gaze aversion and fidgeting. As in previous research, accuracy and confidence were not significantly correlated, but the level of confidence was dependent on whether officers judged actual truths or actual lies and on the method by which confidence was measured.

  15. Zeptomole electrochemical detection of metallothioneins.

    Directory of Open Access Journals (Sweden)

    Vojtech Adam

    Full Text Available BACKGROUND: Thiol-rich peptides and proteins possess a large number of biological activities and may serve as markers for numerous health problems including cancer. Metallothionein (MT, a small molecular mass protein rich in cysteine, may be considered as one of the promising tumour markers. The aim of this paper was to employ chronopotentiometric stripping analysis (CPSA for highly sensitive detection of MT. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we used adsorptive transfer stripping technique coupled with CPSA for detection of cysteine, glutathione oxidized and reduced, phytochelatin, bovine serum albumin, and metallothionein. Under the optimal conditions, we were able to estimate detection limits down to tens of fg per ml. Further, this method was applied to detect metallothioneins in blood serum obtained from patients with breast cancer and in neuroblastoma cells resistant and sensitive to cisplatin in order to show the possible role of metallothioneins in carcinogenesis. It was found that MT level in blood serum was almost twice higher as compared to the level determined in healthy individuals. CONCLUSIONS/SIGNIFICANCE: This paper brings unique results on the application of ultra-sensitive electroanalytical method for metallothionein detection. The detection limit and other analytical parameters are the best among the parameters of other techniques. In spite of the fact that the paper is mainly focused on metallothionein, it is worth mentioning that successful detection of other biologically important molecules is possible by this method. Coupling of this method with simple isolation methods such as antibody-modified paramagnetic particles may be implemented to lab-on-chip instrument.

  16. On Applications of Selenodesy to Lunar Detection

    Institute of Scientific and Technical Information of China (English)

    WEI Erhu; LIU Jingnan


    According to the history of lunar detection, the relationship between selenodesy and lunar detection is reviewed , and the focus of the lunar detection and the lunar detection plan of China are summarized. The key techniques of selenodesy are presented, and the applications of selenodesy to the lunar detection are discussed.

  17. Application of detecting algorithm based on network

    Institute of Scientific and Technical Information of China (English)

    张凤斌; 杨永田; 江子扬; 孙冰心


    Because currently intrusion detection systems cannot detect undefined intrusion behavior effectively,according to the robustness and adaptability of the genetic algorithms, this paper integrates the genetic algorithms into an intrusion detection system, and a detection algorithm based on network traffic is proposed. This algorithm is a real-time and self-study algorithm and can detect undefined intrusion behaviors effectively.

  18. Complementarity between collider, direct detection, and indirect detection experiments

    CERN Document Server

    Cahill-Rowley, Matthew


    We examine the capabilities of planned direct detection, indirect detection, and collider experiments in exploring the 19-parameter p(henomenological)MSSM, focusing on the complementarity between the different search techniques. In particular, we consider dark matter searches at the 7, 8 (and eventually 14) TeV LHC, \\Fermi, CTA, IceCube/DeepCore, and LZ. We see that the search sensitivities depend strongly on the WIMP mass and annihilation mechanism, with the result that different search techniques explore orthogonal territory. We also show that advances in each technique are necessary to fully explore the space of Supersymmetric WIMPs.

  19. Radio frequency detection assembly and method for detecting radio frequencies (United States)

    Cown, Steven H.; Derr, Kurt Warren


    A radio frequency detection assembly is described and which includes a radio frequency detector which detects a radio frequency emission produced by a radio frequency emitter from a given location which is remote relative to the radio frequency detector; a location assembly electrically coupled with the radio frequency detector and which is operable to estimate the location of the radio frequency emitter from the radio frequency emission which has been received; and a radio frequency transmitter electrically coupled with the radio frequency detector and the location assembly, and which transmits a radio frequency signal which reports the presence of the radio frequency emitter.

  20. Software Defect Detection with Rocus

    Institute of Scientific and Technical Information of China (English)

    Yuan Jiang; Ming Li; Zhi-Hua Zhou


    Software defect detection aims to automatically identify defective software modules for efficient software test in order to improve the quality of a software system. Although many machine learning methods have been successfully applied to the task, most of them fail to consider two practical yet important issues in software defect detection. First, it is rather difficult to collect a large amount of labeled training data for learning a well-performing model; second, in a software system there are usually much fewer defective modules than defect-free modules, so learning would have to be conducted over an imbalanced data set. In this paper, we address these two practical issues simultaneously by proposing a novel semi-supervised learning approach named Rocus. This method exploits the abundant unlabeled examples to improve the detection accuracy, as well as employs under-sampling to tackle the class-imbalance problem in the learning process. Experimental results of real-world software defect detection tasks show that Rocgs is effective for software defect detection. Its performance is better than a semi-supervised learning method that ignores the class-imbalance nature of the task and a class-imbalance learning method that does not make effective use of unlabeled data.

  1. Bioreporter bacteria for landmine detection

    Energy Technology Data Exchange (ETDEWEB)

    Burlage, R.S. [Oak Ridge National Lab., TN (United States); Youngblood, T. [Frisby Technologies, Aiken, SC (United States); Lamothe, D. [American Technologies, Inc., Huntsville, AL (United States). Ordnance/Explosives Environmental Services Div.


    Landmines (and other UXO) gradually leak explosive chemicals into the soil at significant concentrations. Bacteria, which have adapted to scavenge low concentrations of nutrients, can detect these explosive chemicals. Uptake of these chemicals results in the triggering of specific bacterial genes. The authors have created genetically recombinant bioreporter bacteria that detect small concentrations of energetic chemicals. These bacteria are genetically engineered to produce a bioluminescent signal when they contact specific explosives. A gene for a brightly fluorescent compound can be substituted for increased sensitivity. By finding the fluorescent bacteria, you find the landmine. Detection might be accomplished using stand-off illumination of the minefield and GPS technology, which would result in greatly reduced risk to the deminers. Bioreporter technology has been proven at the laboratory scale, and will be tested under field conditions in the near future. They have created a bacterial strain that detects sub-micromolar concentrations of o- and p-nitrotoluene. Related bacterial strains were produced using standard laboratory protocols, and bioreporters of dinitrotoluene and trinitrotoluene were produced, screening for activity with the explosive compounds. Response time is dependent on the growth rate of the bacteria. Although frill signal production may require several hours, the bacteria can be applied over vast areas and scanned quickly, producing an equivalent detection speed that is very fast. This technology may be applicable to other needs, such as locating buried explosives at military and ordnance/explosive manufacturing facilities.

  2. Saliency detection for stereoscopic images. (United States)

    Fang, Yuming; Wang, Junle; Narwaria, Manish; Le Callet, Patrick; Lin, Weisi


    Many saliency detection models for 2D images have been proposed for various multimedia processing applications during the past decades. Currently, the emerging applications of stereoscopic display require new saliency detection models for salient region extraction. Different from saliency detection for 2D images, the depth feature has to be taken into account in saliency detection for stereoscopic images. In this paper, we propose a novel stereoscopic saliency detection framework based on the feature contrast of color, luminance, texture, and depth. Four types of features, namely color, luminance, texture, and depth, are extracted from discrete cosine transform coefficients for feature contrast calculation. A Gaussian model of the spatial distance between image patches is adopted for consideration of local and global contrast calculation. Then, a new fusion method is designed to combine the feature maps to obtain the final saliency map for stereoscopic images. In addition, we adopt the center bias factor and human visual acuity, the important characteristics of the human visual system, to enhance the final saliency map for stereoscopic images. Experimental results on eye tracking databases show the superior performance of the proposed model over other existing methods.

  3. Optomechanics for absolute rotation detection (United States)

    Davuluri, Sankar


    In this article, we present an application of optomechanical cavity for the absolute rotation detection. The optomechanical cavity is arranged in a Michelson interferometer in such a way that the classical centrifugal force due to rotation changes the length of the optomechanical cavity. The change in the cavity length induces a shift in the frequency of the cavity mode. The phase shift corresponding to the frequency shift in the cavity mode is measured at the interferometer output to estimate the angular velocity of absolute rotation. We derived an analytic expression to estimate the minimum detectable rotation rate in our scheme for a given optomechanical cavity. Temperature dependence of the rotation detection sensitivity is studied.

  4. Quickest detection in coupled systems

    CERN Document Server

    Hadjiliadis, Olympia; Poor, H Vincent


    This work considers the problem of quickest detection of signals in a coupled system of N sensors, which receive continuous sequential observations from the environment. It is assumed that the signals, which are modeled a general Ito processes, are coupled across sensors, but that their onset times may differ from sensor to sensor. The objective is the optimal detection of the first time at which any sensor in the system receives a signal. The problem is formulated as a stochastic optimization problem in which an extended average Kullback- Leibler divergence criterion is used as a measure of detection delay, with a constraint on the mean time between false alarms. The case in which the sensors employ cumulative sum (CUSUM) strategies is considered, and it is proved that the minimum of N CUSUMs is asymptotically optimal as the mean time between false alarms increases without bound.

  5. Minimax Robust Quickest Change Detection

    CERN Document Server

    Unnikrishnan, Jayakrishnan; Meyn, Sean


    The two popular criteria of optimality for quickest change detection procedures are Lorden's criterion and the Bayesian criterion. In this paper a robust version of these quickest change detection problems is considered when the pre-change and post-change distributions are not known exactly but belong to known uncertainty classes of distributions. For uncertainty classes that satisfy a specific condition, it is shown that one can identify least favorable distributions (LFDs) from the uncertainty classes, such that the detection rule designed for the LFDs is optimal for the robust problem in a minimax sense. The condition is similar to that required for the identification of LFDs for the robust hypothesis testing problem studied by Huber. An upper bound on the delay incurred by the robust test is also obtained in the asymptotic setting under Lorden's criterion of optimality, which quantifies the delay penalty incurred to guarantee robustness. When the LFDs can be identified, the proposed test is easier to impl...

  6. Electochemical detection of chromosome translocation

    DEFF Research Database (Denmark)

    Kwasny, Dorota; Dimaki, Maria; Silahtaroglu, Asli;


    Cytogenetics is a study of the cell structure with a main focus on chromosomes content and their structure. Chromosome abnormalities, such as translocations may cause various genetic disorders and heametological malignancies. Chromosome translocations are structural rearrangements of two...... chromosomes that results in formation of derivative chromosomes with a mixed DNA sequence. The method currently used for their detection is Fluorescent In Situ Hybridization, which requires a use of expensive, fluorescently labeled probes that target the derivative chromosomes. We present here a double...... hybridization approach developed for label-free detection of the chromosome translocations. For specific translocation detection it is necessary to determine that the two DNA sequences forming a derivative chromosome are connected, which is achieved by two subsequent hybridization steps. The electrochemical...

  7. Optimal dynamic detection of explosives

    Energy Technology Data Exchange (ETDEWEB)

    Moore, David Steven [Los Alamos National Laboratory; Mcgrane, Shawn D [Los Alamos National Laboratory; Greenfield, Margo T [Los Alamos National Laboratory; Scharff, R J [Los Alamos National Laboratory; Rabitz, Herschel A [PRINCETON UNIV; Roslund, J [PRINCETON UNIV


    The detection of explosives is a notoriously difficult problem, especially at stand-off distances, due to their (generally) low vapor pressure, environmental and matrix interferences, and packaging. We are exploring optimal dynamic detection to exploit the best capabilities of recent advances in laser technology and recent discoveries in optimal shaping of laser pulses for control of molecular processes to significantly enhance the standoff detection of explosives. The core of the ODD-Ex technique is the introduction of optimally shaped laser pulses to simultaneously enhance sensitivity of explosives signatures while reducing the influence of noise and the signals from background interferents in the field (increase selectivity). These goals are being addressed by operating in an optimal nonlinear fashion, typically with a single shaped laser pulse inherently containing within it coherently locked control and probe sub-pulses. With sufficient bandwidth, the technique is capable of intrinsically providing orthogonal broad spectral information for data fusion, all from a single optimal pulse.

  8. A new vehicle detection method

    Directory of Open Access Journals (Sweden)

    Zebbara Khalid


    Full Text Available This paper presents a new vehicle detection method from images acquired by cameras embedded in a moving vehicle. Given the sequence of images, the proposed algorithms should detect out all cars in realtime. Related to the driving direction, the cars can be classified into two types. Cars drive in the same direction as the intelligent vehicle (IV and cars drive in the opposite direction. Due to the distinct features of these two types, we suggest to achieve this method in two main steps. The first one detects all obstacles from images using the so-called association combined with corner detector. The second step is applied to validate each vehicle using AdaBoost classifier. The new method has been applied to different images data and the experimental results validate the efficacy of our method.

  9. Visual Inspection for Caries Detection

    DEFF Research Database (Denmark)

    Gimenez, T; Piovesan, C; Braga, M M


    We aimed to perform a systematic review including a meta-analysis to evaluate the overall accuracy of visual methods for detecting carious lesions and to identify possible sources of heterogeneity among the studies included. Two reviewers searched PubMed, Embase, Scopus, and other sources through...... July 2014 to identify published and nonpublished studies in English. Studies of visual inspection were included that 1) assessed accuracy of the method in detecting caries lesions; 2) were performed on occlusal, proximal, or free smooth surfaces in primary or permanent teeth; 3) had a reference...... (from 5,808 articles initially identified) and 1 abstract (from 168) met the inclusion criteria. In general, the analysis demonstrated that the visual method had good accuracy for detecting caries lesions. Although laboratory and clinical studies have presented similar accuracy, clinically obtained...

  10. Historical Techniques of Lie Detection

    Directory of Open Access Journals (Sweden)

    Martina Vicianova


    Full Text Available Since time immemorial, lying has been a part of everyday life. For this reason, it has become a subject of interest in several disciplines, including psychology. The purpose of this article is to provide a general overview of the literature and thinking to date about the evolution of lie detection techniques. The first part explores ancient methods recorded circa 1000 B.C. (e.g., God’s judgment in Europe. The second part describes technical methods based on sciences such as phrenology, polygraph and graphology. This is followed by an outline of more modern-day approaches such as FACS (Facial Action Coding System, functional MRI, and Brain Fingerprinting. Finally, after the familiarization with the historical development of techniques for lie detection, we discuss the scope for new initiatives not only in the area of designing new methods, but also for the research into lie detection itself, such as its motives and regulatory issues related to deception.

  11. APDS: Autonomous Pathogen Detection System

    Energy Technology Data Exchange (ETDEWEB)

    Langlois, R G; Brown, S; Burris, L; Colston, B; Jones, L; Makarewicz, T; Mariella, R; Masquelier, D; McBride, M; Milanovich, F; Masarabadi, S; Venkateswaran, K; Marshall, G; Olson, D; Wolcott, D


    An early warning system to counter bioterrorism, the Autonomous Pathogen Detection System (APDS) continuously monitors the environment for the presence of biological pathogens (e.g., anthrax) and once detected, it sounds an alarm much like a smoke detector warns of a fire. Long before September 11, 2001, this system was being developed to protect domestic venues and events including performing arts centers, mass transit systems, major sporting and entertainment events, and other high profile situations in which the public is at risk of becoming a target of bioterrorist attacks. Customizing off-the-shelf components and developing new components, a multidisciplinary team developed APDS, a stand-alone system for rapid, continuous monitoring of multiple airborne biological threat agents in the environment. The completely automated APDS samples the air, prepares fluid samples in-line, and performs two orthogonal tests: immunoassay and nucleic acid detection. When compared to competing technologies, APDS is unprecedented in terms of flexibility and system performance.

  12. Intelligent Detection of Drill Wear (United States)

    Liu, T. I.; Chen, W. Y.; Anatharaman, K. S.


    Backpropagation neural networks (BPNs) were used for on-line detection of drill wear. The neural network consisted of three layers: input, hidden, and output. The input vector comprised drill size, feed rate, spindle speed, and eight features obtained by processing the thrust and torque signals. The output was the drill wear state which either usable or failure. Drilling experiments with various drill sizes, feed rates and spindle speeds were carried out. The learning process was performed effectively by utilising backpropagation with smoothing and an activation function slope. The on-line detection of drill wear states using BPNs achieved 100% reliability even when the drill size, feed rate and spindle speed were changed. In other words, the developed on-line drill wear detection systems have very high robustness and hence can be used in very complex production environments, such as flexible manufacturing systems.

  13. Analog electronics for radiation detection

    CERN Document Server


    Analog Electronics for Radiation Detection showcases the latest advances in readout electronics for particle, or radiation, detectors. Featuring chapters written by international experts in their respective fields, this authoritative text: Defines the main design parameters of front-end circuitry developed in microelectronics technologies Explains the basis for the use of complementary metal oxide semiconductor (CMOS) image sensors for the detection of charged particles and other non-consumer applications Delivers an in-depth review of analog-to-digital converters (ADCs), evaluating the pros and cons of ADCs integrated at the pixel, column, and per-chip levels Describes incremental sigma delta ADCs, time-to-digital converter (TDC) architectures, and digital pulse-processing techniques complementary to analog processing Examines the fundamental parameters and front-end types associated with silicon photomultipliers used for single visible-light photon detection Discusses pixel sensors ...

  14. The detectability of climate engineering (United States)

    Bürger, Gerd; Cubasch, Ulrich


    We assess the detection and attribution (D&A) of climate engineering (CE) as a function of their duration after initiation. We employ "surrogate" climates where observations are mimicked by simulations. Unlike classical, stationary D&A, the null hypothesis for this analysis is the nonstationary gradual warming caused by continued greenhouse gas (GHG) forcing, which creates a number of theoretical and technical complications. Adapting D&A to this nonstationary setting requires several ad hoc assumptions whose validity is analyzed and discussed. We study the stratospheric sulfur injection scenarios G3 and G4 of the Geoengineering Model Intercomparison Project. For G3, which smoothly balances global warming with a corresponding cooling, the effect is smaller initially and harder to detect. Temperature and precipitation signals are detectable about a decade after commencing CE and attributable a few years later (details depending on model and scenario). The G4 scenario consists of a continuous injection of 5 Tg SO2 (roughly one fourth of the Pinatubo eruption per year), which represents a shock-like forcing that is easier and earlier detectable, just after a few years. Later into the century, uncertainty in GHG sensitivity increasingly dominates the background noise, hampering G4 detection. Spatiotemporal CE fingerprints produce more stable D&A results, with smoother dependence on time. Spatial resolution (within the range of a few spherical harmonics) is less relevant. We argue that especially for early detectability, climate predictions (with proper initialization from observations) are more promising. Many details depend on the choice of climate model for observation and fingerprint. We discuss the potential and limitation of using multimodel ensembles.

  15. Community Detection by Neighborhood Similarity

    Institute of Scientific and Technical Information of China (English)

    LIU Xu; XIE Zheng; YI Dong-Yun


    Detection of the community structure in a network is important for understanding the structure and dynamics of the network.By exploring the neighborhood of vertices,a local similarity metric is proposed,which can be quickly computed.The resulting similarity matrix retains the same support as the adjacency matrix.Based on local similarity,an agglomerative hierarchical clustering algorithm is proposed for community detection.The algorithm is implemented by an efficient max-heap data structure and runs in nearly linear time,thus is capable of dealing with large sparse networks with tens of thousands of nodes.Experiments on synthesized and real-world networks demonstrate that our method is efficient to detect community structures,and the proposed metric is the most suitable one among all the tested similarity indices.%Detection of the community structure in a network is important for understanding the structure and dynamics of the network. By exploring the neighborhood of vertices, a local similarity metric is proposed, which can be quickly computed. The resulting similarity matrix retains the same support as the adjacency matrix. Based on local similarity, an agglomerative hierarchical clustering algorithm is proposed for community detection. The algorithm is implemented by an efficient max-heap data structure and runs in nearly linear time, thus is capable of dealing with large sparse networks with tens of thousands of nodes. Experiments on synthesized and real-world networks demonstrate that our method is efficient to detect community structures, and the proposed metric is the most suitable one among all the tested similarity indices.

  16. Anomaly detection enhanced classification in computer intrusion detection

    Energy Technology Data Exchange (ETDEWEB)

    Fugate, M. L. (Michael L.); Gattiker, J. R. (James R.)


    This report describes work with the goal of enhancing capabilities in computer intrusion detection. The work builds upon a study of classification performance, that compared various methods of classifying information derived from computer network packets into attack versus normal categories, based on a labeled training dataset. This previous work validates our classification methods, and clears the ground for studying whether and how anomaly detection can be used to enhance this performance, The DARPA project that initiated the dataset used here concluded that anomaly detection should be examined to boost the performance of machine learning in the computer intrusion detection task. This report investigates the data set for aspects that will be valuable for anomaly detection application, and supports these results with models constructed from the data. In this report, the term anomaly detection means learning a model from unlabeled data, and using this to make some inference about future data. Our data is a feature vector derived from network packets: an 'example' or 'sample'. On the other hand, classification means building a model from labeled data, and using that model to classify unlabeled (future) examples. There is some precedent in the literature for combining these methods. One approach is to stage the two techniques, using anomaly detection to segment data into two sets for classification. An interpretation of this is a method to combat nonstationarity in the data. In our previous work, we demonstrated that the data has substantial temporal nonstationarity. With classification methods that can be thought of as learning a decision surface between two statistical distributions, performance is expected to degrade significantly when classifying examples that are from regions not well represented in the training set. Anomaly detection can be seen as a problem of learning the density (landscape) or the support (boundary) of a statistical

  17. EUROmediCAT signal detection

    DEFF Research Database (Denmark)

    Luteijn, Johannes Michiel; Morris, Joan K; Garne, Ester


    AIMS: Information about medication safety in pregnancy is inadequate. We aimed to develop a signal detection methodology to routinely identify unusual associations between medications and congenital anomalies using data collected by 15 European congenital anomaly registries. METHODS: EUROmediCAT......). CONCLUSIONS: Medication exposure data in the EUROmediCAT central database can be analyzed systematically to determine a manageable set of associations for validation and then testing in independent datasets. Detection of teratogens depends on frequency of exposure, level of risk and teratogenic specificity....

  18. Intrusion Detection using unsupervised learning

    Directory of Open Access Journals (Sweden)

    Kusum bharti


    Full Text Available Clustering is the one of the efficient datamining techniques for intrusion detection. In clustering algorithm kmean clustering is widely used for intrusion detection. Because it gives efficient results incase of huge datasets. But sometime kmean clustering fails to give best result because of class dominance problem and no class problem. So for removing these problems we are proposing two new algorithms for cluster to class assignment. According to our experimental results the proposed algorithm are having high precision and recall for low class instances.

  19. Detecting lateral genetic material transfer

    CERN Document Server

    Calderón, C; Mireles, V; Miramontes, P


    The bioinformatical methods to detect lateral gene transfer events are mainly based on functional coding DNA characteristics. In this paper, we propose the use of DNA traits not depending on protein coding requirements. We introduce several semilocal variables that depend on DNA primary sequence and that reflect thermodynamic as well as physico-chemical magnitudes that are able to tell apart the genome of different organisms. After combining these variables in a neural classificator, we obtain results whose power of resolution go as far as to detect the exchange of genomic material between bacteria that are phylogenetically close.

  20. A contrario line segment detection

    CERN Document Server

    von Gioi, Rafael Grompone


    The reliable detection of low-level image structures is an old and still challenging problem in computer vision. This?book leads a detailed tour through the LSD algorithm, a line segment detector designed to be fully automatic. Based on the a contrario framework, the algorithm works efficiently without the need of any parameter tuning. The design criteria are thoroughly explained and the algorithm's good and bad results are illustrated on real and synthetic images. The issues involved, as well as the strategies used, are common to many geometrical structure detection problems and some possible

  1. On computational Gestalt detection thresholds. (United States)

    Grompone von Gioi, Rafael; Jakubowicz, Jérémie


    The aim of this paper is to show some recent developments of computational Gestalt theory, as pioneered by Desolneux, Moisan and Morel. The new results allow to predict much more accurately the detection thresholds. This step is unavoidable if one wants to analyze visual detection thresholds in the light of computational Gestalt theory. The paper first recalls the main elements of computational Gestalt theory. It points out a precision issue in this theory, essentially due to the use of discrete probability distributions. It then proposes to overcome this issue by using continuous probability distributions and illustrates it on the meaningful alignment detector of Desolneux et al.

  2. Thermographic Detection of separated Flow (United States)

    Dollinger, C.; Balaresque, N.; Schaffarczyk, A. P.; Fischer, A.


    Thermographic wind tunnel measurements, both on a cylinder as well as on a 2D airfoil, were performed at various Reynolds numbers in order to evaluate the possibility of detecting and visualizing separated flow areas. A new approach by acquiring a series of thermographic images and applying a spatial-temporal statistical analysis allows improving both the resolution and the information content of the thermographic images. Separated flow regions become visible and laminar/turbulent transitions can be detected more accurately. The knowledge about possibly present stall cells can be used to confirm two-dimensional flow conditions and support the development of more effective and silent rotorblades.

  3. Intelligent System for Worm Detection

    Directory of Open Access Journals (Sweden)

    Tarek S. Sobh


    Full Text Available Worms are on the top of malware threats attacking computer system although of the evolution of worms detectiontechniques. Early detection of unknown worms is still a problem. This paper produce a method for detecting unknown wormsbased on local victim information. The proposed system uses Artificial Neural Network (ANN for classifying worm/ nonwormtraffic and predicting the percentage of infection in the infected network. This prediction can be used to support decisionmaking process for network administrator to respond quickly to worm propagation in an accurate procedure.

  4. The Bering Autonomous Target Detection

    DEFF Research Database (Denmark)

    Jørgensen, John Leif; Denver, Troelz; Betto, Maurizio


    An autonomous asteroid target detection and tracking method has been developed. The method features near omnidirectionality and focus on high speed operations and completeness of search of the near space rather than the traditional faint object search methods, employed presently at the larger...... telescopes. The method has proven robust in operation and is well suited for use onboard spacecraft. As development target for the method and the associated instrumentation the asteroid research mission Bering has been used. Onboard a spacecraft, the autonomous detection is centered around the fully...

  5. Detection of Water Borne Protozoa

    DEFF Research Database (Denmark)

    Al-Sabi, Mohammad Nafi Solaiman; Enemark, Heidi L.; Kurtzhals, J.A.L.

    Protozoa of several species play a key role in water borne outbreaks of diarrhea worldwide. Identification of such protozoa depends mainly on parasite detection. However, water contains several hundreds of thousands of microorganisms belonging to different taxa. The exact identification...... of pathogenic protozoa relies on selective isolation and detection that is conducted by experienced technicians. Advanced techniques such as immuno-fluorescent dyes, polymerase chain reaction, and many other techniques, may be used for species-specific identification of pathogenic protozoa. Each diagnostic...... parasitic protozoa from other organisms in the aquatic environment....

  6. Detecting and detering employee theft. (United States)

    Stewart, E E


    Physician group practices can limit their vulnerability to employee theft by taking steps to detect theft when it occurs and to deter future occurrences. Steps for detecting theft include being wary of an employee's refusal to take earned time off, conducting periodic credit checks on employees, rotating employees' duties, and conducting impromptu reviews of the practice's finances. Steps for detering theft include routing the practice's checks to a lock box; reviewing cash reports; reconciling check with deposit statements; separating employees' duties; reviewing bank, credit card, and ATM statements; setting the tone for prudent financial management; and reporting cases of theft when they occur.

  7. The Portable Metal Detecting Meter

    Institute of Scientific and Technical Information of China (English)


    Using backscatter principle of ray, one kind of the portable metal detecting meters, which comprises five parts, i.e., a ray-emitter, a ray acceptor, discriminating and forming pulse circuits, storing and processing data units, a light and sound alarm device, and a power supply, had been invented. It can judge existence of danger articles as weapons and daggers hided inside luggages, pracels, or clothing of passengers or persons without opening packing. The detecting distance between the meter and danger objects, at present, is about one meter, but can be extended adopting improvement for key parts. For comparison, up to now, in the whole world, known information

  8. Picosecond measurements using photoacoustic detection (United States)

    Heritier, J.-M.; Siegman, A. E.


    A report is presented of experimental results on picosecond time-resolved photoacoustic measurements of excited-state lifetimes, cross sections, and polarization properties for organic dye molecules in solution, using a new technique in which the total photoacoustic impulse produced by two ultrashort optical pulses with variable time delay between them is detected. The picosecond photoacoustic detection technique reported here appears to be a promising new way to observe weak excited-state cross sections and to perform picosecond lifetime measurements in a large variety of weakly absorbing and/or nonfluorescing atomic and molecular systems.

  9. Fire detection in warehouse facilities

    CERN Document Server

    Dinaburg, Joshua


    Automatic sprinklers systems are the primary fire protection system in warehouse and storage facilities. The effectiveness of this strategy has come into question due to the challenges presented by modern warehouse facilities, including increased storage heights and areas, automated storage retrieval systems (ASRS), limitations on water supplies, and changes in firefighting strategies. The application of fire detection devices used to provide early warning and notification of incipient warehouse fire events is being considered as a component of modern warehouse fire protection.Fire Detection i

  10. Single Bacterium Detection Using Sers (United States)

    Gonchukov, S. A.; Baikova, T. V.; Alushin, M. V.; Svistunova, T. S.; Minaeva, S. A.; Ionin, A. A.; Kudryashov, S. I.; Saraeva, I. N.; Zayarny, D. A.


    This work is devoted to the study of a single Staphylococcus aureus bacterium detection using surface-enhanced Raman spectroscopy (SERS) and resonant Raman spectroscopy (RS). It was shown that SERS allows increasing sensitivity of predominantly low frequency lines connected with the vibrations of Amide, Proteins and DNA. At the same time the lines of carotenoids inherent to this kind of bacterium are well-detected due to the resonance Raman scattering mechanism. The reproducibility and stability of Raman spectra strongly depend on the characteristics of nanostructured substrate, and molecular structure and size of the tested biological object.

  11. Worm attack detection and response

    Institute of Scientific and Technical Information of China (English)

    CHEN Bo; YU Xiangzhan; FANG Binxing; YUN Xiaochun


    There appear many Internet-scale worm incidents in recent years,which have caused severe damage to the society.It is clear that a simple self-propagation worm can quickly spread across the Internet.Therefore,it is necessary to implement automatic mitigation which can detect worm and drop its packet.In this paper,the worm's framework was first analyzed and its two characteristies were detected.Based on the two characteristics,a defending algorithm was presented to protect network.Experimental results verify that our algorithm is very effective to constrain the worm propagation and meanwhile it almost does not interfere in normal activity.

  12. Comparison of time to detect definitions


    Dubois, Laurence M.


    Approved for public release; distribution is unlimited This thesis concerns the measurement of times to detect multiple targets. It compares two common definitions of times to detection--interdetection time, and search time to detection--to a relatively new definition called time in field-of-view until detection. This comparison uses the data from the Thermal Pinpoint Test conducted from July to December 1983. Detection time distributions and mean times to detection were studied, lookin...

  13. Point pattern match-based change detection in a constellation of previously detected objects (United States)

    Paglieroni, David W.


    A method and system is provided that applies attribute- and topology-based change detection to objects that were detected on previous scans of a medium. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, detection strength, size, elongation, orientation, etc. The locations define a three-dimensional network topology forming a constellation of previously detected objects. The change detection system stores attributes of the previously detected objects in a constellation database. The change detection system detects changes by comparing the attributes and topological consistency of newly detected objects encountered during a new scan of the medium to previously detected objects in the constellation database. The change detection system may receive the attributes of the newly detected objects as the objects are detected by an object detection system in real time.

  14. Microvariability Detection of Mrk 421

    Indian Academy of Sciences (India)

    Xu Chen; Shao Ming Hu; Di Fu Guo


    BL Lac object Mrk 421 was observed in optical bands from 2009 April to 2012 May with the 1.0-m telescope at Weihai Observatory of Shandong University. Microvariability was analysed by C and F tests, but no significant microvariability was detected during our observations.

  15. Turning Students into Symmetry Detectives (United States)

    Wilders, Richard; VanOyen, Lawrence


    Exploring mathematical symmetry is one way of increasing students' understanding of art. By asking students to search designs and become pattern detectives, teachers can potentially increase their appreciation of art while reinforcing their perception of the use of math in their day-to-day lives. This article shows teachers how they can interest…

  16. Metamaterial Absorbers for Microwave Detection (United States)


    ABSORBERS FOR MICROWAVE DETECTION by Michael T. McMahan June 2015 Thesis Advisor: Dragoslav Grbovic Co-Advisor: Richard C. Olsen THIS PAGE......presented. 14. SUBJECT TERMS metamaterials, metamaterial absorbers , metamaterial detectors 15. NUMBER OF PAGES 65 16. PRICE

  17. Detecting selection needs comparative data

    DEFF Research Database (Denmark)

    Nielsen, Rasmus; Hubisz, Melissa J.


    Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al. 1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show her...

  18. Computer Viruses: Pathology and Detection. (United States)

    Maxwell, John R.; Lamon, William E.


    Explains how computer viruses were originally created, how a computer can become infected by a virus, how viruses operate, symptoms that indicate a computer is infected, how to detect and remove viruses, and how to prevent a reinfection. A sidebar lists eight antivirus resources. (four references) (LRW)

  19. EUROmediCAT signal detection

    DEFF Research Database (Denmark)

    Given, Joanne E; Loane, Maria; Luteijn, Johannes Michiel


    AIMS: To evaluate congenital anomaly (CA)-medication exposure associations produced by the new EUROmediCAT signal detection system and determine which require further investigation. METHODS: Data from 15 EUROCAT registries (1995-2011) with medication exposures at the chemical substance (5th level...

  20. Adjunct methods for caries detection

    DEFF Research Database (Denmark)

    Twetman, Svante; Axelsson, Susanna Bihari; Dahlén, Gunnar


    Abstract Objective. To assess the diagnostic accuracy of adjunct methods used to detect and quantify dental caries. Study design. A systematic literature search for relevant papers was conducted with pre-determined inclusion and exclusion criteria. Abstracts and full text articles were assessed i...

  1. Experiences with network intrusion detection

    NARCIS (Netherlands)

    Coolen, R.; Luiijf, H.A.M.; Geloven, W.J.F. van; Bakker, E.A.


    This paper describes our experience with several commercial Network Intrusion Detection Systems (NIDSs)deployed in a network connected to the Internet. Specific problems in the operation of NIDS are highlighted, and a number of solutions to identified problems will be presented. Finally, we shall pr

  2. Ship Infrared Detection/Vulnerability

    NARCIS (Netherlands)

    Jong, A.N. de


    The IR contrast of ships at sea is of importance for those who want to detect or identify the ship and for those who worry about this. This IR contrast is determined by a large number of parameters. Of course temperatures of the ship's structure and those of the ambient sea and air are important, bu

  3. System for detecting microbial contamination

    NARCIS (Netherlands)

    Gerritse, J.; Groenestijn, J.W.; Zegers, N.D.


    The present invention relates to a system for detecting microbial contamination of a liquid specimen comprising a device for concentrating micro-organisms from a liquid specimen, having (i) a hypobaric chamber, (ii) a filter housing comprising a liquid-permeable bed of an adsorbent material and adap

  4. Dark Matter Detection in Space


    Feng, Jonathan L.


    I review prospects for detecting dark matter in space-based experiments, with an emphasis on recent developments. I propose the ``Martha Stewart criterion'' for identifying dark matter candidates that are particularly worth investigation and focus on three that satisfy it: neutralino dark matter, Kaluza-Klein dark matter, and superWIMP gravitino dark matter.

  5. Molecular detection of foodborne pathogens

    DEFF Research Database (Denmark)

    Josefsen, Mathilde Hartmann

    ), Scorpion and TaqMan probes. The LNA probe was shown to be the most sensitive probe chemistry in the real-time PCR assay for detection of Campylobacter, producing the highest amplification efficiency. Choice of probe chemistry was found to impact the sensitivity of PCR assays, and should be considered...

  6. Computational Attention for Event Detection


    Mancas, Matei; Couvreur, Laurent; Gosselin, Bernard; Macq, Benoît


    This article deals with a biologically-motivated three-level computational attention model architecture based on the rarity and the information theory framework. It mainly focuses on low-level and medium-level steps and their application in pre-attentive detection of tumours in CT scans and unusual events in audio recordings.

  7. Protein Detection with Aptamer Biosensors

    Directory of Open Access Journals (Sweden)

    Regina Stoltenburg


    Full Text Available Aptamers have been developed for different applications. Their use as new biological recognition elements in biosensors promises progress for fast and easy detection of proteins. This new generation of biosensor (aptasensors will be more stable and well adapted to the conditions of real samples because of the specific properties of aptamers.

  8. Operational formulation of homodyne detection

    CERN Document Server

    Tyc, T; Tyc, Tomas; Sanders, Barry C.


    We obtain the standard quadrature-phase positive operator-valued measure (POVM) for homodyne detection directly and rigorously from the POVM for direct photon counting. In addition we obtain correction terms for the quadrature-phase POVM that are applicable for relatively weak local oscillator field strengths and typical signal states.

  9. Global Disease Detectives in Kibera

    Centers for Disease Control (CDC) Podcasts


    In partnership with our disease detectives, urban poor open their homes to the world to prevent and control emerging diseases.  Created: 12/6/2010 by CDC Center for Global Health.   Date Released: 12/6/2010.

  10. Fault Detection for Nonlinear Systems

    DEFF Research Database (Denmark)

    Stoustrup, Jakob; Niemann, H.H.


    The paper describes a general method for designing fault detection and isolation (FDI) systems for nonlinear processes. For a rich class of nonlinear systems, a nonlinear FDI system can be designed using convex optimization procedures. The proposed method is a natural extension of methods based...

  11. Towards Detection of Unknown GMOs

    NARCIS (Netherlands)

    Holst-Jensen, A.; Berdal, K.G.; Bertheau, Y.; Bohanec, M.; Bohlin, J.; Chaouachi, M.; Gruden, K.; Hamels, S.; Kok, E.J.; Krech, A.; Kristoffersen, A.B.; Laval, V.; Leimanis, S.; Lovoll, M.; Morisset, D.; Nemeth, A.; Papazova, N.; Prins, T.W.; Remacle, J.; Richl, P.; Ruttink, T.; Taverniers, I.; Tengs, T.; Dijk, van J.P.; Wulff, D.; Zel, J.; Zhang, H.; Znidarsic, M.


    The state-of-the-art technology for detection of genetically modified organisms (GMOs) is polymerase chain reaction. The targets are novel sequences such as genes, but the insertion locus sequences are also important for GMO identification. GMOs go through a series of developmental stages, in which

  12. Cousin of Higgs boson detected

    CERN Multimedia


    "A particle with no chage, a very low mass and a lifetime much shorter than a nanosecond, known as the axion, has been detected by the University of Buffalo (UB) physicist who first suggested its existence 30 years ago. (1,5 page)

  13. Detecting non-transiting exoplanets (United States)

    Placek, Ben; Richards, Zachary; Knuth, Kevin H.


    Currently, the most popular way of detecting Extra-solar planets (exoplanets) is via the Transit Method. This method is limited only to planets with orbits such that we observe them transiting their host star. In this work in progress, we propose to identify non-transiting exoplanets in the data currently being collected by the Kepler Space Telescope by detecting orbital phase reflected light variations. Since such variations are due to light from the host star reflected by the planet, we expect this method to work best on closely orbitting large planets. Using the Metropolis-Hastings Monte Carlo and Nested Sampling algorithms, we will determine the presence or absence of nontransiting planets and estimate their orbital parameters such as, orbital inclination, semi-major axis, period, and eccentricity. Our estimates indicate that the development of this technique has the potential to double the number of detectable planets in the Kepler data sets. Here we demonstrate feasibility using portions of data from one of the first transiting planets detected by Kepler, HAT-P-7b.

  14. Detecting Social Polarization and Radicalization

    DEFF Research Database (Denmark)

    Qureshi, Pir Abdul Rasool; Memon, Nasrullah; Wiil, Uffe Kock


    This paper proposes a novel system to detect social polarization and to estimate the chances of violent radicalization associated with it. The required processes for such a system are indicated; it is also analyzed how existing technologies can be integrated into the proposed system to fulfill...

  15. Can Lies Be Detected Unconsciously?

    Directory of Open Access Journals (Sweden)

    David eShanks


    Full Text Available People are typically poor at telling apart truthful and deceptive statements. Based on the Unconscious Thought Theory, it has been suggested that poor lie detection arises from the intrinsic limitations of conscious thinking and can be improved by facilitating the contribution of unconscious thought. In support of this hypothesis, Reinhard, Greifeneder, and Scharmach (2013 observed improved lie detection among participants engaging in unconscious thought. The present study aimed to replicate this unconscious thought advantage using a similar experimental procedure but with an important improvement in a key control condition. Specifically, participants judged the truthfulness of 8 video recordings in three thinking modes: immediately after watching them or after a period of unconscious or conscious deliberation. Results from two experiments (combined N = 226 failed to reveal a significant difference in lie detection accuracy between the thinking modes, even after efforts were made to facilitate the occurrence of an unconscious thought advantage in Experiment 2. The results imply that the unconscious thought advantage in deception detection is not a robust phenomenon.

  16. Anomalous change detection in imagery (United States)

    Theiler, James P.; Perkins, Simon J.


    A distribution-based anomaly detection platform is described that identifies a non-flat background that is specified in terms of the distribution of the data. A resampling approach is also disclosed employing scrambled resampling of the original data with one class specified by the data and the other by the explicit distribution, and solving using binary classification.

  17. Fault detection using (PI) observers

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Stoustrup, J.; Shafai, B.

    The fault detection and isolation (FDI) problem in connection with Proportional Integral (PI) Observers is considered in this paper. A compact formulation of the FDI design problem using PI observers is given. An analysis of the FDI design problem is derived with respectt to the time domain...... properties. A method for design of PI observers applied to FDI is given....

  18. Social Network Aided Plagiarism Detection (United States)

    Zrnec, Aljaž; Lavbic, Dejan


    The prevalence of different kinds of electronic devices and the volume of content on the Web have increased the amount of plagiarism, which is considered an unethical act. If we want to be efficient in the detection and prevention of these acts, we have to improve today's methods of discovering plagiarism. The paper presents a research study where…

  19. The Detectability of Orphan Afterglows (United States)

    Nakar, Ehud; Piran, Tsvi; Granot, Jonathan


    The realization that gamma-ray bursts (GRBs) release a constant amount of energy implies that post-jet-break afterglow evolution is largely universal. For a given redshift, all afterglows should be detected up to a fixed observer angle. We estimate the observed magnitude and the implied detectability of orphan afterglows. We show that for reasonable limiting magnitudes (mlim=25), orphan afterglows will typically be detected from small (~10°) angles away from the GRB jet axis. A detected orphan afterglow generally corresponds to a ``near miss'' of a GRB whose jet is pointing just slightly away from us. With our most optimistic parameters, we expect that 15 orphan afterglows will be recorded in the Sloan Digital Sky Survey, and 35 transients will be recorded in a dedicated 2 m class telescope operating full time for a year in an orphan afterglow search. The rate is smaller by a factor of 15 for our ``canonical'' parameters. We show that for a given facility, an optimal survey should be shallower, covering a larger area, rather than deeper. The limiting magnitude should not be, however, lower than ~23, as in this case, more transients from on-axis GRBs will be discovered than orphan afterglows. About 15% of the transients could be discovered with a second exposure of the same area provided that it follows after 3, 4, and 8 days for mlim=23, 25, and 27, respectively.

  20. Detection in superheated water chromatography

    Energy Technology Data Exchange (ETDEWEB)

    Chienthavorn, O


    Superheated water has been used successfully as an eluent in liquid chromatography and has been coupled to various modes of detection, ultraviolet (UV), fluorescence, and nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). A number of compounds were examined on poly(styrene-divinylbenzene) (PS-DVB), polybutadiene (PBD), and octadecylsilyl bonded silica (ODS) column with isothermal and temperature programmes. The PS-DVB column was mostly used throughout the project as it was the most stable. Not only pure water could serve as superheated water mobile phase; inorganic buffered water and ion-pairing reagent with a concentration of 1-3 mM of the buffer and reagent were also exploited. It was shown that the pH could be controlled during the separation without salt precipitation and the separations followed a conventional reversed-phase HPLC method. Results from fluorescence detection showed good separation of a series of vitamins, such as pyridoxine, riboflavin, thiamine, and some analgesics. The relationship of riboflavin using the detection was linear and the detection limit was seven times higher than that of a conventional method. Simultaneous separation and identification using superheated water chromatography-NMR was demonstrated. With using a stop flow method, NMR spectra of model drugs, namely barbiturates, paracetamol, caffeine and phenacetin were obtained and the results agreed with reference spectra, confirming a perfect separation. A demonstration to obtain COSY spectrum of salicylamide was also performed. The method was expanded to the coupling of superheated water LC to NMR-MS. Results from the hyphenated detection method showed that deuteration and degradation happened in the superheated water conditions. The methyl group hydrogens of pyrimidine ring of sulfonamide and thiamine were exchanged with deuterium. Thiamine was decomposed to 4-methyl-5-thiazoleethanol and both were deuterated under the conditions. (author)

  1. Marker Detection in Aerial Images

    KAUST Repository

    Alharbi, Yazeed


    The problem that the thesis is trying to solve is the detection of small markers in high-resolution aerial images. Given a high-resolution image, the goal is to return the pixel coordinates corresponding to the center of the marker in the image. The marker has the shape of two triangles sharing a vertex in the middle, and it occupies no more than 0.01% of the image size. An improvement on the Histogram of Oriented Gradients (HOG) is proposed, eliminating the majority of baseline HOG false positives for marker detection. The improvement is guided by the observation that standard HOG description struggles to separate markers from negatives patches containing an X shape. The proposed method alters intensities with the aim of altering gradients. The intensity-dependent gradient alteration leads to more separation between filled and unfilled shapes. The improvement is used in a two-stage algorithm to achieve high recall and high precision in detection of markers in aerial images. In the first stage, two classifiers are used: one to quickly eliminate most of the uninteresting parts of the image, and one to carefully select the marker among the remaining interesting regions. Interesting regions are selected by scanning the image with a fast classifier trained on the HOG features of markers in all rotations and scales. The next classifier is more precise and uses our method to eliminate the majority of the false positives of standard HOG. In the second stage, detected markers are tracked forward and backward in time. Tracking is needed to detect extremely blurred or distorted markers that are missed by the previous stage. The algorithm achieves 94% recall with minimal user guidance. An average of 30 guesses are given per image; the user verifies for each whether it is a marker or not. The brute force approach would return 100,000 guesses per image.

  2. Landmine Detection Technologies to TraceExplosive Vapour Detection Techniques

    Directory of Open Access Journals (Sweden)

    J. C. Kapoor


    Full Text Available Large quantity of explosive is manufactured worldwide for use in various types of ammunition,arms, and mines, and used in armed conflicts. During manufacturing and usage of the explosiveequipment, some of the explosive residues are released into the environment in the form ofcontaminated effluents, unburnt explosives fumes and vapours. Limited but uncontrolledcontinuous release of trace vapours also takes place when explosive-laden landmines are deployedin the field. One of the major technological challenges in post-war scenario worldwide is thedetection of landmines using these trace vapour signatures and neutralising them safely.  Differenttypes of explosives are utilised as the main charge in antipersonnel and antitank landmines. Inthis paper, an effort has been made to review the techniques so far available based on explosivevapour detection especially to detect the landmines. A comprehensive compilation of relevantinformation on the techniques is presented, and their maturity levels, shortcomings, and difficultiesfaced are highlighted.

  3. Countering countermeasures: detecting identity lies by detecting conscious breakthrough.

    Directory of Open Access Journals (Sweden)

    Howard Bowman

    Full Text Available One major drawback of deception detection is its vulnerability to countermeasures, whereby participants wilfully modulate their physiological or neurophysiological response to critical guilt-determining stimuli. One reason for this vulnerability is that stimuli are usually presented slowly. This allows enough time to consciously apply countermeasures, once the role of stimuli is determined. However, by increasing presentation speed, stimuli can be placed on the fringe of awareness, rendering it hard to perceive those that have not been previously identified, hindering the possibility to employ countermeasures. We tested an identity deception detector by presenting first names in Rapid Serial Visual Presentation and instructing participants to lie about their own identity. We also instructed participants to apply a series of countermeasures. The method proved resilient, remaining effective at detecting deception under all countermeasures.

  4. Real-Time Detection of a Virus Using Detection Dogs

    Directory of Open Access Journals (Sweden)

    Craig eAngle


    Full Text Available Viral infections are ubiquitous in humans, animals, and plants. Real-time methods to identify viral infections are limited and do not exist for use in harsh or resource-constrained environments. Previous research identified that tissues produce unique volatile organic compounds (VOC and demonstrated that VOC concentrations change during pathologic states including infection, neoplasia, or metabolic disease. Patterns of VOC expression may be pathogen-specific and may be associated with an odor that could be used for disease detection.We investigated the ability of two trained dogs to detect cell cultures infected with bovine viral diarrhea virus (BVDV and to discriminate BVDV-infected cell cultures from uninfected cell cultures and from cell cultures infected with bovine herpes virus 1 (BHV 1 and bovine parainfluenza virus 3 (BPIV 3. Dogs were trained to recognize cell cultures infected with two different biotypes of BVDV propagated in MDBK cells using one of three culture media. For detection trials, one target and seven distractors were presented on a scent wheel by a dog handler unaware of the location of targets and distractors.Detection of BVDV- infected cell cultures by Dog 1 had a diagnostic sensitivity of 0.850 (95% CI: 0.701 - 0.942, which was lower than Dog 2 (0.967, 95% CI: 0.837 - 0.994. Both dogs exhibited very high diagnostic specificity (0.981, 95% CI: 0.960 - 0.993 and (0.993, 95% CI: 0.975 - 0.999, respectively.These findings demonstrate that trained dogs can differentiate between cultured cells infected with BVDV, BHV1, and BPIV3 and are a realistic real-time mobile pathogen sensing technology for viral pathogens. The ability to discriminate between target and distractor samples plausibly results from expression of unique VOC patterns virus-infected and uninfected cells.

  5. Effective LiDAR Damage Detection: Comparing Two Detection Algorithms

    Institute of Scientific and Technical Information of China (English)

    BIAN Haitao; BAI Libin; WANG Xiaoyu; LIU Wangiu; CHEN Shenen; WANG Shengguo


    The health conditions of highway bridges is critical for sustained transportation operations. US federal government mandates that all bridges built with public funds are to be inspected visually every two years.There is a growing consensus that additional rapid and non-intrusive methods for bridge damage evaluation are needed. This paper explores the potential of applying ground-based laser scanners for bridge damage evaluation. LiDAR has the potential of providing high-density, full-field surface static imaging. Hence, it can generate volumetric quantification of concrete corrosion or steel erosion. By recording object surface topology, LiDAR can detect different damages on the bridge structure and differentiate damage types according to the surface flatness and smoothness. To determine the effectiveness of LiDAR damage detection, two damage detection algorithms are presented and compared using scans on actual bridge damages. The results demonstrate and validate LiDAR damage quantification, which can be a powerful tool for bridge condition evaluation.

  6. A three-dimensional vortex microsystem designed and fabricated for controllable mixing

    Institute of Scientific and Technical Information of China (English)


    A three-dimensional micromixer is designed and fabricated by using glass-poly(dimethylsiloxane)(PDMS) hybridized materials.The improvement of the fabrication process makes the micromixer endure much higher flow rate.Based on the self-rotation effect of the fluid,the fast mixing can be achieved.The mixing process is evaluated by connecting the micromixer to a UV-Vis detector.The results show that by adjusting the infuse flow rate,the mixing process can be accurately controlled.

  7. Integration of evidence-based knowledge management in microsystems: a tele-ICU experience. (United States)

    Rincon, Teresa A


    The Institute of Medicine's proposed 6 aims to improve health care are timely, safe, effective, efficient, equitable, and patient-centered care. Unfortunately, it also asserts that improvements in these 6 dimensions cannot be achieved within the existing framework of care systems. These systems are based on unrealistic expectations on human cognition and vigilance, and demonstrate a lack of dependence on computerized systems to support care processes and put information at the point of use. Knowledge-based care and evidence-based clinical decision-making need to replace the unscientific care that is being delivered in health care. Building care practices on evidence within an information technology platform is needed to support sound clinical decision-making and to influence organizational adoption of evidence-based practice in health care. Despite medical advances and evidence-based recommendations for treatment of severe sepsis, it remains a significant cause of mortality and morbidity in the world. It is a complex disease state that has proven difficult to define, diagnose, and treat. Supporting bedside teams with real-time knowledge and expertise to target early identification of severe sepsis and compliance to Surviving Sepsis Campaign, evidence-based practice bundles are important to improving outcomes. Using a centralized, remote team of expert nurses and an open-source software application to advance clinical decision-making and execution of the severe sepsis bundle will be examined.

  8. Advanced Microsystems for Automotive Applications 2015 : Smart Systems for Green and Automated Driving

    CERN Document Server

    Müller, Beate; Meyer, Gereon


    This edited volume presents the proceedings of the AMAA 2015 conference, Berlin, Germany. The topical focus of the 2015 conference lies on smart systems for green and automated driving. The automobile of the future has to respond to two major trends, the electrification of the drivetrain, and the automation of the transportation system. These trends will not only lead to greener and safer driving but re-define the concept of the car completely, particularly if they interact with each other in a synergetic way as for autonomous parking and charging, self-driving shuttles or mobile robots. Key functionalities like environment perception are enabled by electronic components and systems, sensors and actuators, communication nodes, cognitive systems and smart systems integration. The book will be a valuable read for research experts and professionals in the automotive industry but the book may also be beneficial for graduate students.

  9. Rapid prototyping tools and methods for all-Topas (R) cyclic olefin copolymer fluidic microsystems

    DEFF Research Database (Denmark)

    Bundgaard, Frederik; Perozziello, Gerardo; Geschke, Oliver


    , good machinability, and good optical properties. A number of different processes for rapid and low-cost prototyping of all-Topas microfluidic systems, made with desktop machinery, are presented. Among the processes are micromilling of fluidic structures with a width down to 25 p,m and sealing...

  10. Topas Based Lab-on-a-chip Microsystems Fabricated by Thermal Nanoimprint Lithography

    DEFF Research Database (Denmark)

    Olsen, Brian Bilenberg; Hansen, Michael Søren; Özkapici, V.


    We, present a one-step technology for fabrication of Topas-based lab-on-a-chip (LOC) microsysterris by the use of thermal nanoimprint lithography (NIL). The technology is demonstrated by the fabrication of two working devices: a particle separator and a LOC with integrated optics for absorbance...

  11. Media processors using a new microsystem architecture designed for the Internet era (United States)

    Wyland, David C.


    The demands of digital image processing, communications and multimedia applications are growing more rapidly than traditional design methods can fulfill them. Previously, only custom hardware designs could provide the performance required to meet the demands of these applications. However, hardware design has reached a crisis point. Hardware design can no longer deliver a product with the required performance and cost in a reasonable time for a reasonable risk. Software based designs running on conventional processors can deliver working designs in a reasonable time and with low risk but cannot meet the performance requirements. What is needed is a media processing approach that combines very high performance, a simple programming model, complete programmability, short time to market and scalability. The Universal Micro System (UMS) is a solution to these problems. The UMS is a completely programmable (including I/O) system on a chip that combines hardware performance with the fast time to market, low cost and low risk of software designs.

  12. Implementation of ion-beam techniques in microsystems manufacturing: opportunities in cell biology (United States)

    Campo, E. M.; Lopez-Martinez, M. J.; Fernández, E.; Esteve, J..; Plaza, J. A.


    Micromachining techniques are proposed to mass-manufacture innovative silicon oxide micropipettes and conventional boron-silicate pipettes with highly customized tips to address increasingly demanding cell handling procedures. Cell handling has become a crucial procedure in cell biology, especially in nuclear transfer, DNA injection, and in assisted reproductive techniques. Most pipette manufacturing procedures involve tedious artisanal methods prone to failure and with limited functionality. We expect high tip customization to have a large impact in current and future cell manipulation, paving the way for augmented functionality. Although proper biocompatibility assessments remain to be explored, initial pierced embryos are seen to continue their division procedure up to at least 24 hours. The continued cellular division is a good sign of biocompatibility. These results suggest that residual chemical agents or gallium ions injected during milling could be harmless to life development. We conclude that we have produced a novel technique combining microfabrication and Focus Ion Beam processes with great potential for industrial applications.


    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

  14. Flame spray deposition of porous catalysts on surfaces and in microsystems

    DEFF Research Database (Denmark)

    Thybo, Susanne; Jensen, Søren; Johansen, Johnny;


    . With shadow masks, porous catalyst layers can be deposited selectively into microchannels. Using Au/TiO$_2$ as test catalyst and CO-oxidation as test reaction, it is found that the apparent activation energy of the deposited catalyst is similar to what is normally seen for supported gold catalysts...... in the literature. The surface area of the deposited material is more than twice as large as when the flame-produced material is collected on a filter at the outlet of the flame reactor unit....

  15. Directing functional chemistries on micropatterned conducting polymers for all-polymer cell analysis microsystems

    DEFF Research Database (Denmark)

    Lind, Johan Ulrik; Daugaard, Anders Egede; Andresen, Thomas Lars;

    Micrometer scale electrical circuits of PEDOT (poly(3,4-dioxythiophene)) were created by locally oxidizing PEDOT thin films with an agarose stamp containing the oxidizing agent NaOCl. The oxidized PEDOT was removed completely by applying detergents. The process was sufficiently mild that chemical...

  16. Insider action research and the microsystem of a Danish surgical ward

    DEFF Research Database (Denmark)

    Paltved, Charlotte; Mørcke, Anne Mette; Musaeus, Peter


    This insider action research project aimed to improve interprofessional team performance at a surgical ward. The purpose of the project was (1) to critically appraise potential deficiencies in staffs’ identification, clinical judgment, and management of deteriorating ward patients, (2) to develop...

  17. Reconfigurable Switched-Capacitor Power Converters Principles and Designs for Self-Powered Microsystems

    CERN Document Server

    Ma, Dongsheng


    This book provides readers specializing in ultra-low power supply design for self-powered applications, an invaluable reference on reconfigurable switched capacitor power converters. Readers will benefit from a comprehensive introduction to the design of robust power supplies for energy harvesting and self-power applications, focusing on the use of reconfigurable switched capacitor based DC-DC converters, which is ideal for such applications.  Coverage includes all aspects of switched capacitor power supply designs, from fundamentals, to reconfigurable power stages, and sophisticated controller designs.    Provides a comprehensive introduction to the fundamentals of switched capacitor power supply design for novices, as well as advanced design and implementation  techniques for advanced readers; Includes discussion of all aspects of switched capacitor power supply designs, from fundamentals, to reconfigurable power stages, and sophisticated controller designs; Covers most state-of-art power supply design...

  18. Automated Design Tools for Integrated Mixed-Signal Microsystems (NeoCAD) (United States)


    the modulator using gnuplot . 115 I Gnuplot . . -20 ""netO us 3:4- -40 -60 -80 -100 -120 -140 -160 -180 0 500 1000 1500 2000 Fig. 3: FFT of the output...Fig. 4: 3-Latch Quantizer test circuit with input of 250mV at 980MHz The HAARSPICE-ese results are plotted with gnuplot are shown below 蕈... Gnuplot 2.1 1.9 1.8 1.5 -40 1 2 3 4 5 6 7 89, to Fig. 5: 3-Latch Quantizer output Performance Metrics HAARSPICE-ese performance for a 3-latch Quantizer used

  19. A Novel Transdermal Power Transfer Device for the Application of Implantable Microsystems

    Directory of Open Access Journals (Sweden)

    Jing-Quan Liu


    Full Text Available This paper presents a transdermal power transfer device for the application of implantable devices or systems. The device mainly consists of plug and socket. The power transfer process can be started after inserting the plug into the socket with an applied potential on the plug. In order to improve the maneuverability and reliability of device during power transfer process, the metal net with mesh structure were added as a part of the socket to serve as intermediate electrical connection layer. The socket was encapsulated by polydimethylsiloxane (PDMS with good biocompatibility and flexibility. Two stainless steel hollow needles placed in the same plane acted as the insertion part of the needle plug, and Parylene C thin films were deposited on needles to serve as insulation layers. At last, the properties of the transdermal power transfer device were tested. The average contact resistance between needle and metal mesh was 0.454 Ω after 50 random insertions, which showed good electrical connection. After NiMH (nickel-metal hydride batteries were recharged for 10 min with current up to 200 mA, the caused resistive heat was less than 0.6 °C, which also demonstrated the low charging temperature and was suitable for charging implantable devices.

  20. 现代显微成像技术综述%Imaging technology in modern microsystems

    Institute of Scientific and Technical Information of China (English)



    概述了光学宽视场显微镜、共聚焦显微镜、超分辨率显微镜中所应用的现代显微成像技术,对各种传统和先进的显微成像原理进行了总结。光学宽视场显微镜最常用的显微技术有明场成像、暗场成像、相衬成像、偏光成像、微分干涉(DIC)成像、调制对比成像和荧光成像。相衬成像中根据不同的成像结构还有切趾相衬成像。微分干涉除了传统的偏振光照明还有圆偏振光照明(C-DIC)和专用于塑料的微分干涉(PlasDIC)。共聚焦显微镜随着计算机技术和制造技术的发展而有了巨大的发展。除了传统的共聚焦荧光显微镜以外,还有连续反斯托克斯拉曼散射(CARS)共聚焦、多光子共聚焦和白光共聚焦。超分辨率显微镜中主要介绍了受激辐射淬灭(STED)技术和紧随基态淬灭显微技术的单分子返回(GSDIM)技术。%The imaging technology in modern microscope for widefield microscope,confocal microscope and super-resolution microscope is outlined here. The most frequently-used technology in the widefield microscope is brightfield,darkfield,phase contrast,polarization, DIC,modulation contrast and fluorescence.In phase contrast,there is also apodized phase contrast.In addition,DIC,C-DIC and PlasDIC are also presented.Confocal microscope is developed greatly with the development of computer and manufacture technology.Besides conventional confocal system,the principle of coherent anti-Stokes Raman scattering(CARS) confocal,multi-photo confocal,white confocal are also explained in detail.As for super-resolution microscope,the principle of stimulated emission depletion(STED)and ground state depletion microscopy followed by individual molecule return(GSDIM)are clarified.