WorldWideScience

Sample records for causeway immigration checkpoint

  1. Exposure to methyl tert-butyl ether, benzene, and total hydrocarbons at the Singapore-Malaysia causeway immigration checkpoint

    Energy Technology Data Exchange (ETDEWEB)

    Tan, C.; Ong, H.Y.; Kok, P.W. [and others

    1996-12-31

    The primary aim of this study was to determine the extent and levels of exposure to volatile organic compounds (VOCs) from automobile emissions in a group of immigration officers at a busy cross-border checkpoint. A majority (80%) of the workers monitored were exposed to benzene at levels between 0.01 and 0.5 ppm, with only 1.2% exceeding the current Occupational Safety and Health Administration occupational exposure limit of 1 ppm. The geometric mean (GM) concentrations of 8-hr time-weighted average exposure were 0.03 ppm, 0.9 ppm, and 2.46 ppm for methyl-tert-butyl ether (MTBE), benzene, and total hydrocarbons (THC), respectively. The highest time-weighted average concentrations measured were 1.05 ppm for MTBE, 2.01 ppm for benzene, and 34 ppm for THC. It was found that motorbikes emitted a more significant amount of pollutants compared with motor cars. On average, officers at the motorcycle booths were exposed to four to five times higher levels of VOCs (GMs of 0.07 ppm, 0.23 ppm, and 4.7 ppm for MTBE, benzene, and THC) than their counterparts at the motor car booths (GMs of 0.01 ppm, 0.05 ppm, and 1.5 ppm). The airborne concentrations of all three pollutants correlated with the flow of vehicle traffic. Close correlations were also noted for the concentrations in ambient air for the three pollutants measured. Benzene and MTBE had a correlation coefficient of 0.97. The overall findings showed that the concentrations of various VOCs were closely related to the traffic density, suggesting that they were from a common source, such as exhaust emissions from the vehicles. The results also indicated that although benzene, MTBE, and THC are known to be volatile, a significant amount could still be detected in the ambient environment, thus contributing to our exposure to these compounds. 4 refs., 6 figs.

  2. Immune checkpoints

    OpenAIRE

    Chawla, Akhil; Philips, Anne V; Alatrash, Gheath; Mittendorf, Elizabeth,

    2014-01-01

    Early clinical trials investigating monoclonal antibodies targeting the T-cell inhibitory receptor programmed cell death 1 (PD-1) and its ligand PD-L1 have shown efficacy in melanoma, non-small cell lung cancer and renal cell carcinoma. We recently demonstrated PD-L1 expression in 20% of triple negative breast cancers suggesting that targeting the PD-1/PD-L1 immune checkpoint may be an effective treatment modality in patients with this disease.

  3. Modeling the effect of Causeways on Circulation in the Banana River

    Science.gov (United States)

    Saberi, A.; Weaver, R. J.

    2015-12-01

    The Indian River Lagoon (IRL) is a restricted estuary along the east coast of Florida. Although Banana River, a 50 km long sub-basin of IRL, has an outlet to the ocean through the Port Canaveral locks, the locks remain closed when there is no passing vessel. The lack of direct ocean connection results in limited circulation, long flushing time and poor water quality. Existence of the causeways limits the circulation even more. In this study, the impact of the causeways on flushing time is studied. This study also examines the extent to which constructing a low crested weir adjacent to Port Canaveral can improve flushing in this region. ADCIRC 2DDI is forced with meteorological inputs as well as tides to simulate the hydrodynamic properties of the study area and determine the 2D depth-averaged velocity field for four separate cases: Existing System with and without consideration of the causeways, and modified system (adding a weir near port Canaveral) with and without consideration of the causeways. Passive particles are placed in Banana River, and their movement is tracked using a Lagrangian Particle Tracking Model (LPTM). Transport timescales are then computed, and residence time contours as well as pathlines of selected particles are plotted. Results indicate that the narrow raised pathway section of the causeways acts as a plate which diverts the flow direction and generates eddies in the downstream which causes the particles in the vicinity of the causeways remain in the domain for a longer duration. There is a longer residence time for the case in which the causeways are considered. The results with the added weir suggest a noticeable improvement in flushing time and residence time even for the case in which the causeways are considered in the model.

  4. Checkpoint control and cancer

    Czech Academy of Sciences Publication Activity Database

    Medema, R.H.; Macůrek, Libor

    2012-01-01

    Roč. 31, č. 21 (2012), s. 2601-2613. ISSN 0950-9232 R&D Projects: GA ČR GAP301/10/1525; GA ČR GPP305/10/P420 Institutional support: RVO:68378050 Keywords : DNA damage * checkpoint control * anticancer strategies Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 7.357, year: 2012

  5. Checkpoint inhibition in meningiomas.

    Science.gov (United States)

    Bi, Wenya Linda; Wu, Winona W; Santagata, Sandro; Reardon, David A; Dunn, Ian F

    2016-06-01

    Meningiomas are increasingly appreciated to share similar features with other intra-axial central nervous system neoplasms as well as systemic cancers. Immune checkpoint inhibition has emerged as a promising therapy in a number of cancers, with durable responses of years in a subset of patients. Several lines of evidence support a role for immune-based therapeutic strategies in the management of meningiomas, especially high-grade subtypes. Meningiomas frequently originate juxtaposed to venous sinuses, where an anatomic conduit for lymphatic drainage resides. Multiple populations of immune cells have been observed in meningiomas. PD-1/PD-L1 mediated immunosuppression has been implicated in high-grade meningiomas, with association between PD-L1 expression with negative prognostic outcome. These data point to the promise of future combinatorial therapeutic strategies in meningioma. PMID:27197540

  6. Toward an Optimal Online Checkpoint Solution under a Two-Level HPC Checkpoint Model

    OpenAIRE

    Di, Sheng; Robert, Yves; Vivien, Frédéric; Cappello, Franck

    2016-01-01

    The traditional single-level checkpointing method suffers from significantoverhead on large-scale platforms. Hence, multilevel checkpointing protocols have been studied extensively in recent years. The multilevel checkpoint approach allows different levels of checkpoints to be set (each with different checkpoint overheads and recovery abilities), in order to further improve the fault tolerance performance of extreme-scale HPC applications. How to optimize the checkpoint intervals for each lev...

  7. Efficient Incremental Checkpointing of Java Programs

    DEFF Research Database (Denmark)

    Lawall, Julia Laetitia; Muller, Gilles

    2000-01-01

    This paper investigates the optimization of language-level checkpointing of Java programs. First, we describe how to systematically associate incremental checkpoints with Java classes. While being safe, the genericness of this solution induces substantial execution overhead. Second, to solve...

  8. Cambridge checkpoint English workbook 1

    CERN Document Server

    Reynolds, John

    2013-01-01

    This Workbook supports our bestselling Checkpoint English series, with exercises specifically matched to the Cambridge Progression tests and the Checkpoint English tests. - Offers plenty of additional questions for use in class or as homework. - Includes clearly identified questions on grammar and punctuation, comprehension, use of language and essay planning. - Follows the structure of the relevant textbook to ensure a thorough understanding of all aspects of the course. - Provides a space for Students to write their answers. This Workbook is matched to the Cambridge Secondary 1 Curriculum Fr

  9. Network support for system initiated checkpoints

    Science.gov (United States)

    Chen, Dong; Heidelberger, Philip

    2013-01-29

    A system, method and computer program product for supporting system initiated checkpoints in parallel computing systems. The system and method generates selective control signals to perform checkpointing of system related data in presence of messaging activity associated with a user application running at the node. The checkpointing is initiated by the system such that checkpoint data of a plurality of network nodes may be obtained even in the presence of user applications running on highly parallel computers that include ongoing user messaging activity.

  10. Construction of a Causeway Bridge across the Lake Urmia and its Influence on Drying Trend of the Lake

    Science.gov (United States)

    Ghadimi, M.; Nezammahalleh, M. A.

    2015-12-01

    Construction of a causeway bridge on the Lake Urmia accelerated the drying trend of the largest hyper-saline lake of the world. The objective of the research is to investigate the differences of precipitation and river discharge before and after initiation of the construction of the bridge in 2000. The study area was the watershed of the lake. The averages of the precipitation data in the two periods before and after the project have been interpolated by IDW based on GIS Geostatistical Analyst. The two interpolated precipitation layers were used to be plugged into Student T-test equation in GIS in a spatial basis. To do this, the study area was divided to 25 regions based on drainage sub-basins. Less than 30 sample areas were randomly selected as cases from each of the regions to put into the equation. The discharge data were also compared for the two periods. The results indicated that except in some limited areas, the precipitation differences in the two periods are significant. This means that there were little changes in precipitation and river discharge in the area and consequently the drying may be caused mainly by hydrodynamic changes in the lake due to construction of the causeway. However, it can be argued that the changes in the lake's surface area are accompanied by changes in precipitation and river discharge. The t test statistic can be applied samples based on spatial analysis.

  11. Checkpointing for a hybrid computing node

    Science.gov (United States)

    Cher, Chen-Yong

    2016-03-08

    According to an aspect, a method for checkpointing in a hybrid computing node includes executing a task in a processing accelerator of the hybrid computing node. A checkpoint is created in a local memory of the processing accelerator. The checkpoint includes state data to restart execution of the task in the processing accelerator upon a restart operation. Execution of the task is resumed in the processing accelerator after creating the checkpoint. The state data of the checkpoint are transferred from the processing accelerator to a main processor of the hybrid computing node while the processing accelerator is executing the task.

  12. DNA damage checkpoint recovery and cancer development

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Haiyong [First affiliated hospital, Zhejiang University, School of medicine, Cancer Center, 79 Qingchun Road, Hangzhou 310003 (China); Zhang, Xiaoshan [Department of Genetics, University of Texas M.D. Anderson Cancer Center, Department of Genetics Unit 1010, 1515 Holcombe Blvd. Houston, TX 77030 (United States); Teng, Lisong, E-mail: lsteng@zju.edu.cn [First affiliated hospital, Zhejiang University, School of medicine, Cancer Center, 79 Qingchun Road, Hangzhou 310003 (China); Legerski, Randy J., E-mail: rlegersk@mdanderson.org [Department of Genetics, University of Texas M.D. Anderson Cancer Center, Department of Genetics Unit 1010, 1515 Holcombe Blvd. Houston, TX 77030 (United States)

    2015-06-10

    Cell cycle checkpoints were initially presumed to function as a regulator of cell cycle machinery in response to different genotoxic stresses, and later found to play an important role in the process of tumorigenesis by acting as a guard against DNA over-replication. As a counterpart of checkpoint activation, the checkpoint recovery machinery is working in opposition, aiming to reverse the checkpoint activation and resume the normal cell cycle. The DNA damage response (DDR) and oncogene induced senescence (OIS) are frequently found in precancerous lesions, and believed to constitute a barrier to tumorigenesis, however, the DDR and OIS have been observed to be diminished in advanced cancers of most tissue origins. These findings suggest that when progressing from pre-neoplastic lesions to cancer, DNA damage checkpoint barriers are overridden. How the DDR checkpoint is bypassed in this process remains largely unknown. Activated cytokine and growth factor-signaling pathways were very recently shown to suppress the DDR and to promote uncontrolled cell proliferation in the context of oncovirus infection. In recent decades, data from cell line and tumor models showed that a group of checkpoint recovery proteins function in promoting tumor progression; data from patient samples also showed overexpression of checkpoint recovery proteins in human cancer tissues and a correlation with patients' poor prognosis. In this review, the known cell cycle checkpoint recovery proteins and their roles in DNA damage checkpoint recovery are reviewed, as well as their implications in cancer development. This review also provides insight into the mechanism by which the DDR suppresses oncogene-driven tumorigenesis and tumor progression. - Highlights: • DNA damage checkpoint works as a barrier to cancer initiation. • DDR machinary response to genotoxic and oncogenic stress in similar way. • Checkpoint recovery pathways provide active signaling in cell cycle control. • Checkpoint

  13. DNA damage checkpoint recovery and cancer development

    International Nuclear Information System (INIS)

    Cell cycle checkpoints were initially presumed to function as a regulator of cell cycle machinery in response to different genotoxic stresses, and later found to play an important role in the process of tumorigenesis by acting as a guard against DNA over-replication. As a counterpart of checkpoint activation, the checkpoint recovery machinery is working in opposition, aiming to reverse the checkpoint activation and resume the normal cell cycle. The DNA damage response (DDR) and oncogene induced senescence (OIS) are frequently found in precancerous lesions, and believed to constitute a barrier to tumorigenesis, however, the DDR and OIS have been observed to be diminished in advanced cancers of most tissue origins. These findings suggest that when progressing from pre-neoplastic lesions to cancer, DNA damage checkpoint barriers are overridden. How the DDR checkpoint is bypassed in this process remains largely unknown. Activated cytokine and growth factor-signaling pathways were very recently shown to suppress the DDR and to promote uncontrolled cell proliferation in the context of oncovirus infection. In recent decades, data from cell line and tumor models showed that a group of checkpoint recovery proteins function in promoting tumor progression; data from patient samples also showed overexpression of checkpoint recovery proteins in human cancer tissues and a correlation with patients' poor prognosis. In this review, the known cell cycle checkpoint recovery proteins and their roles in DNA damage checkpoint recovery are reviewed, as well as their implications in cancer development. This review also provides insight into the mechanism by which the DDR suppresses oncogene-driven tumorigenesis and tumor progression. - Highlights: • DNA damage checkpoint works as a barrier to cancer initiation. • DDR machinary response to genotoxic and oncogenic stress in similar way. • Checkpoint recovery pathways provide active signaling in cell cycle control. • Checkpoint

  14. Visualizing the spindle checkpoint in Drosophila spermatocytes

    OpenAIRE

    Rebollo, Elena; González, Cayetano

    2000-01-01

    The spindle assembly checkpoint detects defects in spindle structure or in the alignment of the chromosomes on the metaphase plate and delays the onset of anaphase until defects are corrected. Thus far, the evidence regarding the presence of a spindle checkpoint during meiosis in male Drosophila has been indirect and contradictory. On the one hand, chromosomes without pairing partners do not prevent meiosis progression. On the other hand, some conserved components of the spindle checkpoint ma...

  15. GRID COMPUTING AND CHECKPOINT APPROACH

    Directory of Open Access Journals (Sweden)

    Pankaj gupta

    2011-05-01

    Full Text Available Grid computing is a means of allocating the computational power of alarge number of computers to complex difficult computation or problem. Grid computing is a distributed computing paradigm thatdiffers from traditional distributed computing in that it is aimed toward large scale systems that even span organizational boundaries. In this paper we investigate the different techniques of fault tolerance which are used in many real time distributed systems. The main focus is on types of fault occurring in the system, fault detection techniques and the recovery techniques used. A fault can occur due to link failure, resource failure or by any other reason is to be tolerated for working the system smoothly and accurately. These faults can be detected and recovered by many techniques used accordingly. An appropriate fault detector can avoid loss due to system crash and reliable fault tolerance technique can save from system failure. This paper provides how these methods are applied to detect and tolerate faults from various Real Time Distributed Systems. The advantages of utilizing the check pointing functionality are obvious; however so far the Grid community has notdeveloped a widely accepted standard that would allow the Gridenvironment to consciously utilize low level check pointing packages.Therefore, such a standard named Grid Check pointing Architecture isbeing designed. The fault tolerance mechanism used here sets the jobcheckpoints based on the resource failure rate. If resource failureoccurs, the job is restarted from its last successful state using acheckpoint file from another grid resource. A critical aspect for anautomatic recovery is the availability of checkpoint files. A strategy to increase the availability of checkpoints is replication. Grid is a form distributed computing mainly to virtualizes and utilize geographically distributed idle resources. A grid is a distributed computational and storage environment often composed of

  16. Overlapped checkpointing with hardware assist

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Christopher J [Los Alamos National Laboratory; Nunez, James A [Los Alamos National Laboratory; Wang, Jun [U. OF CENTRAL FLORIDA (UCF)

    2009-01-01

    We present a new approach to handling the demanding I/O workload incurred during checkpoint writes encountered in High Performance Computing. Prior efforts to improve performance have been primarily bound by mechanical limitations of the hard drive. Our research surpasses this limitation by providing a method to: (1) write checkpoint data to a high-speed, non-volatile buffer, and (2) asynchronously write this data to permanent storage while resuming computation. This removes the hard drive from the critical data path because our I/O node based buffers isolate the compute nodes from the storage servers. This solution is feasible because of industry declines in cost for high-capacity, non-volatile storage technologies. Testing was conducted on a small-scale cluster to prove the design, and then scaled at Los Alamos National Laboratory. Results show a definitive speedup factor for select workloads over writing directly to a typical global parallel file system; the Panasas ActiveScale File System.

  17. Kinase signaling in the spindle checkpoint.

    Science.gov (United States)

    Kang, Jungseog; Yu, Hongtao

    2009-06-01

    The spindle checkpoint is a cell cycle surveillance system that ensures the fidelity of chromosome segregation. In mitosis, it elicits the "wait anaphase" signal to inhibit the anaphase-promoting complex or cyclosome until all chromosomes achieve bipolar microtubule attachment and align at the metaphase plate. Because a single kinetochore unattached to microtubules activates the checkpoint, the wait anaphase signal is thought to be generated by this kinetochore and is then amplified and distributed throughout the cell to inhibit the anaphase-promoting complex/cyclosome. Several spindle checkpoint kinases participate in the generation and amplification of this signal. Recent studies have begun to reveal the activation mechanisms of these checkpoint kinases. Increasing evidence also indicates that the checkpoint kinases not only help to generate the wait anaphase signal but also actively correct kinetochore-microtubule attachment defects. PMID:19228686

  18. Visualizing the spindle checkpoint in Drosophila spermatocytes

    Science.gov (United States)

    Rebollo, Elena; González, Cayetano

    2000-01-01

    The spindle assembly checkpoint detects defects in spindle structure or in the alignment of the chromosomes on the metaphase plate and delays the onset of anaphase until defects are corrected. Thus far, the evidence regarding the presence of a spindle checkpoint during meiosis in male Drosophila has been indirect and contradictory. On the one hand, chromosomes without pairing partners do not prevent meiosis progression. On the other hand, some conserved components of the spindle checkpoint machinery are expressed in these cells and behave as their homologue proteins do in systems with an active spindle checkpoint. To establish whether the spindle checkpoint is active in Drosophila spermatocytes we have followed meiosis progression by time-lapse microscopy under conditions where the checkpoint is likely to be activated. We have found that the presence of a relatively high number of misaligned chromosomes or a severe disruption of the meiotic spindle results in a significant delay in the time of entry into anaphase. These observations provide the first direct evidence substantiating the activity of a meiotic spindle checkpoint in male Drosophila. PMID:11256627

  19. REVIEW OF CHECKPOINTING ALGORITHMS IN DISTRIBUTED SYSTEMS

    Directory of Open Access Journals (Sweden)

    Poonam Gahlan

    2010-06-01

    Full Text Available Checkpointing is the process of saving the status information. Checkpoint is defined as a designated place in a program at which normal processing is interrupted specifically to preserve the status information necessary to allow resumption of processing at a later time. Mobile computing raises many new issues such as lack of stablestorage, low bandwidth of wireless channel, high mobility, and limited battery life. Coordinated checkpointing is an attractive approach for transparently adding fault tolerance to distributed applications since it avoids domino effects and minimizes the stable storage requirement. This paper presents the review of the algorithms,which have been reported in the literature for checkpointing. This paper also covers backward error recovery techniques for distributed systems specially the distributed mobile systems.

  20. A Nonblocking Coordinated Checkpointing Algorithm for Mobile Computing Systems

    Directory of Open Access Journals (Sweden)

    Rachit Garg

    2010-05-01

    Full Text Available A checkpoint algorithm for mobile computing systems needs to handle many new issues like: mobility, low bandwidth of wireless channels, lack of stable storage on mobile nodes, disconnections, limited battery power and high failure rate of mobile nodes. These issues make traditional checkpointing techniques unsuitable for such environments. Minimum-process coordinated checkpointing is an attractive approach to introduce fault tolerance in mobile distributed systems transparently. This approach is domino-free, requires at most two checkpoints of a process on stable storage, and forces only a minimum number of processes to checkpoint. But, it requires extra synchronization messages, blocking of the underlying computation or taking some useless checkpoints. In this paper, we propose a nonblocking coordinated checkpointing algorithm for mobile computing systems, which requires only a minimum number of processes to take permanent checkpoints. We reduce the message complexity as compared to the Cao-Singhal algorithm [4], while keeping the number of useless checkpoints unchanged. We also address the related issues like: failures during checkpointing, disconnections, concurrent initiations of the algorithm and maintaining exact dependencies among processes. Finally, the paper presents an optimization technique, which significantly reduces the number of useless checkpoints at the cost of minor increase in the message complexity. In coordinated checkpointing, if a single process fails to take its tentative checkpoint; all the checkpoint effort is aborted. We try to reduce this effort by taking soft checkpoints in the first phase at Mobile Hosts.

  1. Ethnosizing Immigrants

    OpenAIRE

    Constant, Amelie F.; Gataullina, Liliya; Zimmermann, Klaus F.

    2006-01-01

    The paper provides a new measure of the ethnic identity of immigrants and explores its evolution in the host country. The ethnosizer, a measure of the intensity of a person's ethnic identity, is constructed from information on the following elements: language, culture, societal interaction, history of migration, and ethnic self-identification. A two-dimensional concept of the ethnosizer classifies immigrants into four states: integration, assimilation, separation and marginalization. We find ...

  2. Asynchronous Checkpoint Migration with MRNet in the Scalable Checkpoint / Restart Library

    Energy Technology Data Exchange (ETDEWEB)

    Mohror, K; Moody, A; de Supinski, B R

    2012-03-20

    Applications running on today's supercomputers tolerate failures by periodically saving their state in checkpoint files on stable storage, such as a parallel file system. Although this approach is simple, the overhead of writing the checkpoints can be prohibitive, especially for large-scale jobs. In this paper, we present initial results of an enhancement to our Scalable Checkpoint/Restart Library (SCR). We employ MRNet, a tree-based overlay network library, to transfer checkpoints from the compute nodes to the parallel file system asynchronously. This enhancement increases application efficiency by removing the need for an application to block while checkpoints are transferred to the parallel file system. We show that the integration of SCR with MRNet can reduce the time spent in I/O operations by as much as 15x. However, our experiments exposed new scalability issues with our initial implementation. We discuss the sources of the scalability problems and our plans to address them.

  3. Checkpoint triggering in a computer system

    Energy Technology Data Exchange (ETDEWEB)

    Cher, Chen-Yong

    2016-09-06

    According to an aspect, a method for triggering creation of a checkpoint in a computer system includes executing a task in a processing node of the computer system and determining whether it is time to read a monitor associated with a metric of the task. The monitor is read to determine a value of the metric based on determining that it is time to read the monitor. A threshold for triggering creation of the checkpoint is determined based on the value of the metric. Based on determining that the value of the metric has crossed the threshold, the checkpoint including state data of the task is created to enable restarting execution of the task upon a restart operation.

  4. Garbage Collection in Uncoordinated Checkpointing Algorithms

    Institute of Scientific and Technical Information of China (English)

    LIU Yunlong; CHEN Junliang

    1999-01-01

    In this paper, the hard problem of thethorough garbage collection in uncoordinated checkpointing algorithms isstudied. After introduction of the traditional garbage collectingscheme, with which only obsolete checkpoints can be discarded, it isshown that this kind of traditional method may fail to discard anycheckpoint in some special cases, and it is necessary and urgent to finda thorough garbage collecting method, with which all the checkpointsuseless for any future rollback-recovery including the obsolete ones canbe discarded. Then, the Thorough Garbage Collection Theorem is proposedand proved, which ensures the feasibility of the thorough garbagecollection, and gives the method to calculate the set of the usefulcheckpoints as well.

  5. Checkpointing and Recovery in Distributed and Database Systems

    Science.gov (United States)

    Wu, Jiang

    2011-01-01

    A transaction-consistent global checkpoint of a database records a state of the database which reflects the effect of only completed transactions and not the results of any partially executed transactions. This thesis establishes the necessary and sufficient conditions for a checkpoint of a data item (or the checkpoints of a set of data items) to…

  6. Immigrant selection systems and immigrant health

    OpenAIRE

    Chiswick, Barry R; Lee, Yew Liang; Paul W. Miller

    2006-01-01

    This paper is an analysis of the determinants of self-reported health status of immigrants, with a particular focus on type of visa used to gain admission. The concept of health capital” and an immigrant selection and adjustment model are employed. The empirical analysis uses the three waves of the Longitudinal Survey of Immigrants to Australia (panel I). Immigrant health is greater for immigrants who are younger, more educated, male, more proficient in English, and living outside of an immig...

  7. Targeting the Checkpoint to Kill Cancer Cells

    Czech Academy of Sciences Publication Activity Database

    Benada, Jan; Macůrek, Libor

    2015-01-01

    Roč. 6, č. 3 (2015), s. 1912-1937. ISSN 2218-273X R&D Projects: GA ČR(CZ) GA14-34264S Institutional support: RVO:68378050 Keywords : checkpoint * DNA damage response * cancer Subject RIV: EB - Genetics ; Molecular Biology

  8. Immigration Reform: 1986 & Today

    OpenAIRE

    Woods, Gregory

    2013-01-01

    In 1986 president Ronald Reagan passed the largest immigration bill in American history. He granted amnesty to nearly three million undocumented immigrants, but many still considered this immigration bill to be a failure. The 1986 Amnesty Act, more properly known as the Immigration Reform and Control Act of 1986 (IRCA), was supposed to secure the border, crack down on businesses that continued to hire undocumented immigrants and put an end to illegal immigration here in the United States. It ...

  9. Germany; an Immigration Country

    OpenAIRE

    Siebert, Horst

    2003-01-01

    Germany has about the same proportion of foreigners in its population as the United States, it is an immigration country. In a way, Germany has let immigration happen, but it did not really have an explicit immigration policy in the past. Now it has to make up its mind on its immigration policy in the future. The paper looks at the experience with immigration in the past, at the integration of foreigners and at the issues of immigration policy.

  10. Replication licensing and the DNA damage checkpoint

    OpenAIRE

    Cook, Jeanette Gowen

    2009-01-01

    Accurate and timely duplication of chromosomal DNA requires that replication be coordinated with processes that ensure genome integrity. Significant advances in determining how the earliest steps in DNA replication are affected by DNA damage have highlighted some of the mechanisms to establish that coordination. Recent insights have expanded the relationship between the ATM and ATR-dependent checkpoint pathways and the proteins that bind and function at replication origins. These findings sug...

  11. Immune Checkpoint Inhibitors in Older Adults.

    Science.gov (United States)

    Elias, Rawad; Morales, Joshua; Rehman, Yasser; Khurshid, Humera

    2016-08-01

    Cancer is primarily a disease of older adults. The treatment of advanced stage tumors usually involves the use of systemic agents that may be associated with significant risk of toxicity, especially in older patients. Immune checkpoint inhibitors are newcomers to the oncology world with improved efficacy and better safety profiles when compared to traditional cytotoxic drugs. This makes them an attractive treatment option. While there are no elderly specific trials, this review attempts to look at the current available data from a geriatric oncology perspective. We reviewed data from phase III studies that led to newly approved indications of checkpoint inhibitors in non-small cell lung cancer, melanoma, and renal cell cancer. Data were reviewed with respect to response, survival, and toxicity according to three groups: 75 years. Current literature does not allow one to draw definitive conclusions regarding the role of immune checkpoint inhibitors in older adults. However, they may offer a potentially less toxic but equally efficacious treatment option for the senior adult oncology patient. PMID:27287329

  12. The New Asian Immigrants.

    Science.gov (United States)

    Wong, Morrison G.; Hirschman, Charles

    In the early 1960s, Asian immigration to the United States was severely limited. The passage of the Immigration Act of 1965 expanded Asian immigration and ended a policy of racial discrimination and exclusion. Currently, over one third of the total immigrant population to the United States is from Asia, particularly China, Japan, Korea, the…

  13. An Anti-Checkpoint Activity for Rif1

    OpenAIRE

    Xue, Yuan; Rushton, Michael D.; Maringele, Laura

    2011-01-01

    Cells accumulate single-stranded DNA (ssDNA) when telomere capping, DNA replication, or DNA repair is impeded. This accumulation leads to cell cycle arrest through activating the DNA–damage checkpoints involved in cancer protection. Hence, ssDNA accumulation could be an anti-cancer mechanism. However, ssDNA has to accumulate above a certain threshold to activate checkpoints. What determines this checkpoint-activation threshold is an important, yet unanswered question. Here we identify Rif1 (R...

  14. A Monitor for Bud Emergence in the Yeast Morphogenesis Checkpoint

    OpenAIRE

    Theesfeld, Chandra L.; Zyla, Trevin R.; Bardes, Elaine G.S.; Lew, Daniel J.

    2003-01-01

    Cell cycle transitions are subject to regulation by both external signals and internal checkpoints that monitor satisfactory progression of key cell cycle events. In budding yeast, the morphogenesis checkpoint arrests the cell cycle in response to perturbations that affect the actin cytoskeleton and bud formation. Herein, we identify a step in this checkpoint pathway that seems to be directly responsive to bud emergence. Activation of the kinase Hsl1p is dependent upon...

  15. Immigrant Families in Australia

    OpenAIRE

    Jock Collins

    1992-01-01

    Australia has a larger and more diverse immigrant population than most Western societies. Australia's immigration history is linked to the story of family migration as Australia sought immigrants for permanent settlement. However, it is important to aviod over-generalisation when studying immigrant families in Australia today. The main hypothesis is that in order to understand the immigrant family in Australia today it is necessary to study the intersection of factors such as ethnicity, class...

  16. Immigration Enforcement and Crime

    OpenAIRE

    Paolo Pinotti

    2015-01-01

    Immigration enforcement has ambiguous implications for the crime rate of undocumented immigrants. On the one hand, expulsions reduce the pool of immigrants at risk of committing crimes, on the other they lower the opportunity cost of crime for those who are not expelled. We estimate the effect of expulsions on the crime rate of undocumented immigrants in Italy exploiting variation in enforcement toward immigrants of different nationality, due to the existence of bilateral agreements for the c...

  17. Immigrants and Religion

    OpenAIRE

    Chiswick, Carmel U.

    2014-01-01

    Religious considerations affect the decision to immigrate as well as the choice of destination country, and religious behaviors change as immigrants adjust to the economic context of their new country. This paper considers the interaction between the Economics of Religion and the Economics of Immigration, and distinguishes between religiosity per se and an immigrant's religious identity (affiliation). Religious groups are described as quasi-enclaves and immigrant churches as a subset of these...

  18. Immigrant Settlement Services Literacy

    OpenAIRE

    Mambo Tabu Masinda

    2014-01-01

    The global migration is transforming the social fabric of modern societies around the world. As a result, countries hosting large number of immigrants have developed a range of services to help immigrants adjust to their new countries. Many studies have investigated immigrant services, however, there is no discussion looking at immigrant services under what I call ¡°Immigrant settlement services literacy¡± (ISSL). This paper aims to close this gap. The discussion proposes some implications fo...

  19. Immigration and Firm Expansion

    OpenAIRE

    William W. Olney

    2008-01-01

    Research generally focuses on how immigration affects native workers, while the impact of immigration on domestic firms is often overlooked. This paper addresses this important omission by examining whether firms respond to immigration by expanding their production activities within a city in order to utilize the abundant supply of low-skilled workers. Using data on immigration and the universe of establishments in U.S. cities, the results indicate that firms respond to immigration at the ext...

  20. Auctioning Immigration Visas

    OpenAIRE

    Collie, David R.

    2007-01-01

    Freeman (2006) suggested that auctioning immigration visas and redistributing the revenue to native residents in the host country would increase migration from low-income to high-income countries. The effect of the auctioning of immigration visas, in the Ricardian model from Findlay (1982), on the optimal level of immigration for the host country is considered. It is shown that auctioning immigration visas will lead to a positive level of immigration only if the initial wage difference betwee...

  1. Slope Failure Hazards at Basalt Geomorphosites: A Comparative Analysis of the Giant's Causeway World Heritage Site, UK and Penghu Marine Geopark, Taiwan.

    Science.gov (United States)

    Gruendemann, Ciaran; Chung Lin, Jiun; Smith, Bernard

    2010-05-01

    Columnar basalt landscapes hold a fascination that transcends geographical and cultural boundaries. It is because of this that they feature so prominently on the global register of significant geomorphosites. Arguably the most iconic of these basalt landscapes is the Giant's Causeway in Northern Ireland, a status recognized by its inscription as a World Heritage Site. Recognition at this level invariably brings visitor pressure, and with it concern as to the impact they exert on site integrity. Rarely, however, is the same overt concern expressed for the risks that such sites pose to the visitors - or not at least until disaster strikes. Yet, the very features that make these sites attractive - tall, exposed, largely unconstrained columns - render many of them intrinsically unstable, prone to catastrophic collapse and potentially hazardous to visitors. In this presentation we highlight the nature of these slope instability issues through a comparative analysis of two geographically contrasting basalt geomorphosites. Investigations of slope hazard at the Giant's Causeway have shown that many are linked to the distinctive structural characteristics and weathering patterns of flood basalts. Typically, individual flows comprise a columnar ‘colonnade', topped by a blocky ‘entablature' and separated from the flows above and below it by a structurally weaker, but often less-permeable, palaeosol that formed during periods of volcanic quiescence. The collapse of columns is often facilitated by a combination of weathering along ever-widening joints and wedging outwards by debris that falls into them. This gradual distortion of the colonnade makes columns increasingly susceptible to collapse. Often this is triggered by intense rainfall (perhaps following a dry spell) that rapidly infiltrates joints and is ponded on the underlying palaeosol. The precise nature of the failure (toppling or outwards rotation of the column base) is largely dictated by the nature of the

  2. Anaphase onset before complete DNA replication with intact checkpoint responses

    DEFF Research Database (Denmark)

    Torres-Rosell, Jordi; De Piccoli, Giacomo; Cordon-Preciado, Violeta;

    2007-01-01

    Cellular checkpoints prevent mitosis in the presence of stalled replication forks. Whether checkpoints also ensure the completion of DNA replication before mitosis is unknown. Here, we show that in yeast smc5-smc6 mutants, which are related to cohesin and condensin, replication is delayed, most...

  3. Immune checkpoint inhibition in lymphoid disease.

    Science.gov (United States)

    Eyre, Toby A; Collins, Graham P

    2015-08-01

    It has long been understood that the immune system has intrinsic anti-tumour activity in humans, and that a key mechanism of tumour progression is the ability of a tumour to escape this immune surveillance. A number of attempts have been made to harness this anti-tumour immunity in both solid tumour oncology and haematological malignancies with variable success. Examples include the use of allogeneic stem cell transplantation and donor lymphocyte infusion in haematological cancer and vaccine studies in solid tumours. Enhanced signalling of the Programmed cell death-1 (PDCD1, PD-1)/cytotoxic T-lymphocyte-associated protein 4 (CTLA4) 'immune checkpoint' pathway has emerged recently as a critical mechanism by which tumours can escape the natural anti-tumour immune response. As such, novel therapies have been developed to help enhance this natural immunity by switching off the PDCD1/CTLA4 immune checkpoint pathway. The following review will discuss the pathobiology of these pathways and the exciting new data now available in lymphoid malignancies. PMID:25824455

  4. Developmental checkpoints guarded by regulated necrosis.

    Science.gov (United States)

    Dillon, Christopher P; Tummers, Bart; Baran, Katherine; Green, Douglas R

    2016-06-01

    The process of embryonic development is highly regulated through the symbiotic control of differentiation and programmed cell death pathways, which together sculpt tissues and organs. The importance of programmed necrotic (RIPK-dependent necroptosis) cell death during development has recently been recognized as important and has largely been characterized using genetically engineered animals. Suppression of necroptosis appears to be essential for murine development and occurs at three distinct checkpoints, E10.5, E16.5, and P1. These distinct time points have helped delineate the molecular pathways and regulation of necroptosis. The embryonic lethality at E10.5 seen in knockouts of caspase-8, FADD, or FLIP (cflar), components of the extrinsic apoptosis pathway, resulted in pallid embryos that did not exhibit the expected cellular expansions. This was the first suggestion that these factors play an important role in the inhibition of necroptotic cell death. The embryonic lethality at E16.5 highlighted the importance of TNF engaging necroptosis in vivo, since elimination of TNFR1 from casp8 (-/-), fadd (-/-), or cflar (-/-), ripk3 (-/-) embryos delayed embryonic lethality from E10.5 until E16.5. The P1 checkpoint demonstrates the dual role of RIPK1 in both the induction and inhibition of necroptosis, depending on the upstream signal. This review summarizes the role of necroptosis in development and the genetic evidence that helped detail the molecular mechanisms of this novel pathway of programmed cell death. PMID:27056574

  5. Immune checkpoints in cancer clinical trials

    Institute of Scientific and Technical Information of China (English)

    Elad Sharon; Howard Streicher; Priscila Goncalves; Helen XChen

    2014-01-01

    Immunology-based therapy is rapidly developing into an effective treatment option for a surprising range of cancers. We have learned over the last decade that powerful immunologic effector cells may be blocked by inhibitory regulatory pathways controlled by specific molecules often called“immune checkpoints.” These checkpoints serve to control or turn off the immune response when it is no longer needed to prevent tissue injury and autoimmunity. Cancer cells have learned or evolved to use these mechanisms to evade immune control and elimination. The development of a new therapeutic class of drugs that inhibit these inhibitory pathways has recently emerged as a potent strategy in oncology. Three sets of agents have emerged in clinical trials exploiting this strategy. These agents are antibody-based therapies targeting cytotoxic T-lymphocyte antigen4 (CTLA4), programmed cell death1 (PD-1), and programmed cell death ligand 1 (PD-L1). These inhibitors of immune inhibition have demonstrated extensive activity as single agents and in combinations. Clinical responses have been seen in melanoma, renal cellcarcinoma, non-smal celllung cancer, and several other tumor types. Despite the autoimmune or inflammatory immune-mediated adverse effects which have been seen, the responses and overall survival benefits exhibited thus far warrant further clinical development.

  6. Checkpoint kinase 1 negatively regulates somatic hypermutation.

    Science.gov (United States)

    Frankenberger, Samantha; Davari, Kathrin; Fischer-Burkart, Sabine; Böttcher, Katrin; Tomi, Nils-Sebastian; Zimber-Strobl, Ursula; Jungnickel, Berit

    2014-04-01

    Immunoglobulin (Ig) diversification by somatic hypermutation in germinal center B cells is instrumental for maturation of the humoral immune response, but also bears the risk of excessive or aberrant genetic changes. Thus, introduction of DNA damage by activation-induced cytidine deaminase as well as DNA repair by multiple pathways need to be tightly regulated during the germinal center response to prevent lymphomagenesis. In the present study, we show that DNA damage checkpoint signaling via checkpoint kinase 1 (Chk1) negatively regulates somatic hypermutation. Chk1 inhibition in human B cell lymphoma lines as well as inactivation of Chk1 alleles by gene targeting in DT40 B cells leads to increased somatic hypermutation. This is apparently due to changes in DNA repair pathways regulated by Chk1, such as a decreased homologous recombination efficiency that also leads to decreased Ig gene conversion in DT40. Our data show that Chk1 signaling plays a crucial role in regulation of Ig diversification and sheds unexpected light on potential origins of aberrant somatic hypermutation in B cell lymphomagenesis. PMID:24423870

  7. DMTCP: Scalable User-Level Transparent Checkpointing for Cluster Computations

    CERN Document Server

    Ansel, Jason; Arya, Kapil

    2008-01-01

    As the size of clusters increases, failures are becoming increasingly frequent. Applications must become fault tolerant if they are to run for extended periods of time. We present DMTCP (Distributed MultiThreaded CheckPointing), the first user-level distributed checkpointing package not dependent on a specific message passing library. This contrasts with existing approaches either specific to libraries such as MPI or requiring kernel modification. DMTCP provides fault tolerance through checkpointing. DMTCP transparently checkpoints general cluster computations consisting of many nodes, processes, and threads. DMTCP automatically accounts for TCP/IP sockets, UNIX domain sockets, pipes, ptys (pseudo-terminals), signal handlers, ordinary file descriptors, shared file descriptors, and other operating system artifacts. We demonstrate checkpointing and restart of applications communicating through MPICH2, OpenMPI, and sockets directly. These applications were written with a variety of languages including Fortran, C...

  8. Poverty and Immigration Policy

    OpenAIRE

    Oberman, Kieran

    2015-01-01

    What are the ethical implications of global poverty for immigration policy? This article finds substantial evidence that migration is effective at reducing poverty. There is every indication that the adoption of a fairly open immigration policy by rich countries, coupled with selective use of immigration restrictions in cases of deleterious brain drain, could be of significant assistance to people living in poor countries. Empirically there is nothing wrong with using immigration policy to ad...

  9. A Market for Immigration

    OpenAIRE

    Israelsen, Karl E.; Israelsen, L. Dwight; Israelsen, William J.

    2006-01-01

    Illegal immigration imposes large economic costs on U.s. taxpayers. The costs are disproportionately concentrated on citizens of southern border states and of other states in which illegal immigrants concentrate. The illegal immigrants themselves also suffer significant costs of migration, such as monetary payments for transportation to or across the border and physical costs, including death. These costs, as well as the benefits to the economy of the illegal immigrant labor force, have been ...

  10. Do Immigrants Cause Crime?

    OpenAIRE

    Milo Bianchi; Paolo Buonanno; Paolo Pinotti

    2008-01-01

    In this paper we examine the empirical relationship between immigration and crime across Italian provinces during the period 1990-2003. Drawing on police administrative data, we first document that the size of immigrant population is positively correlated with the incidence of most types of crime, as well as with the overall number of criminal offenses. However, using changes of immigrant population in other European countries to identify exogenous shifts of immigrant population in Italy, the...

  11. Do Immigrants Cause Crime?

    OpenAIRE

    Bianchi, Milo; Buonanno, Paolo; Pinotti, Paolo

    2010-01-01

    We examine the empirical relationship between immigration and crime across Italian provinces during the period 1990-2003. Drawing on police administrative records, we first document that the size of the immigrant population is positively correlated with the incidence of property crimes and with the overall crime rate. Then, we use instrumental variables based on immigration toward destination countries other than Italy to identify the causal impact of exogenous changes in Italy's immigrant po...

  12. Do Immigrants Cause Crime?.

    OpenAIRE

    Bianchi, Milo; Buonanno, Paolo; Pinotti, Paolo

    2012-01-01

    We examine the empirical relationship between immigration and crime across Italian provinces during the period 1990-2003. Drawing on police administrative records, we first document that the size of the immigrant population is positively correlated with the incidence of property crimes and with the overall crime rate. Then, we use instrumental variables based on immigration toward destination countries other than Italy to identify the causal impact of exogenous changes in Italy's immigrant po...

  13. Do Immigrants Cause Crime?

    OpenAIRE

    Bianchi, Milo; Buonanno, Paolo; Pinotti, Paolo

    2012-01-01

    We examine the empirical relationship between immigration and crime across Italian provinces during the period 1990-2003. Drawing on police administrative records, we first document that the size of the immigrant population is positively correlated with the incidence of property crimes and with the overall crime rate. Then, we use instrumental variables based on immigration toward destination countries other than Italy to identify the causal impact of exogenous changes in Italy's immigrant po...

  14. Immigrant America: A Portrait

    OpenAIRE

    Rumbaut, RG; Portes, A.

    2014-01-01

    This revised, updated, and expanded fourth edition of Immigrant America: A Portrait provides readers with a comprehensive and current overview of immigration to the United States in a single volume. Updated with the latest available data, Immigrant America explores the economic, political, spatial, and linguistic aspects of immigration; the role of religion in the acculturation and social integration of foreign minorities; and the adaptation process for the second generation. This revised ed...

  15. Attitudes towards immigration

    DEFF Research Database (Denmark)

    Malchow-Møller, Nikolaj; Munch, Jakob Roland; Skaksen, Jan Rose;

    2008-01-01

    Using the European Social Survey 2002/3, we develop a new test of whether economic self-interest influences people's attitudes towards immigration, exploiting that people have widely different perceptions of the consequences of immigration......Using the European Social Survey 2002/3, we develop a new test of whether economic self-interest influences people's attitudes towards immigration, exploiting that people have widely different perceptions of the consequences of immigration...

  16. Crime and immigration

    OpenAIRE

    Bell, Brian

    2014-01-01

    Immigration is one of the most important policy debates in Western countries. However, one aspect of the debate is often mischaracterized by accusations that higher levels of immigration lead to higher levels of crime. The evidence, based on empirical studies of many countries, indicates that there is no simple link between immigration and crime. Crucially, the evidence points to substantial differences in the impact on property crime, depending on the labor market opportunities of immigrant ...

  17. Attitudes towards Immigration

    DEFF Research Database (Denmark)

    Dinesen, Peter Thisted; Klemmensen, Robert; Nørgaard, Asbjørn Sonne

    2016-01-01

    immigration: scoring higher on this trait implies a greater willingness to admit immigrants. Moreover, individuals react differently to economic threat depending on their score on the traits Agreeableness and Conscientiousness. Specifically, individuals scoring low on Agreeableness and individuals scoring...... high on Conscientiousness are more sensitive to the skill level of immigrants. The results imply that personality is important for attitudes toward immigration, and in the conclusion, we further discuss how the observed conditional and unconditional effects of personality make sense theoretically....

  18. The Ideal Immigrant

    Science.gov (United States)

    Delgadillo, Theresa

    2011-01-01

    The public discourse about immigration in the United States has long been fraught with xenophobia and racism. Since 9/11, moreover, the immigration issue has been firmly linked to questions of national security in the public imagination. In this recent period, the state has asserted extraordinary controls over immigrants and citizens that affect…

  19. A New Immigration Policy.

    Science.gov (United States)

    Dummett, Anne

    This book focuses on the issue of immigration to the United Kingdom (U.K.). Causes of migration, such as economic opportunities and emergency political refuge, are discussed in terms of the need for the government to devise an effective and just immigration system. Immigration laws of Norway, Sweden, Australia, Canada, and the U.K. are outlined,…

  20. FORMAL VERIFICATION OF DISTRIBUTED CHECKPOINTING USING EVENT-B

    Directory of Open Access Journals (Sweden)

    Girish Chandra

    2015-10-01

    Full Text Available The development of complex system makes challenging task for correct software development. Due to faulty specification, software may involve errors. The traditional testing methods are not sufficient to verify the correctness of such complex system. In order to capture correct system requirements and rigorous reasoning about the problems, formal methods are required. Formal methods are mathematical techniques that provide precise specification of problems with their solutions and proof of correctness. In this paper, we have done formal verification of check pointing process in a distributed database system using Event B. Event-B is an event driven formal method which is used to develop formal models of distributed database systems. In a distributed database system, the database is stored at different sites that are connected together through the network. Checkpoint is a recovery point which contains the state information about the site. In order to do recovery of a distributed transaction a global checkpoint number (GCPN is required. A global checkpoint number decides which transaction will be included for recovery purpose. All transactions whose timestamp are less than global checkpoint number will be marked as before checkpoint transaction (BCPT and will be considered for recovery purpose. The transactions whose timestamp are greater than GCPN will be marked as after checkpoint transaction (ACPT and will be part of next global checkpoint number.

  1. Keeping checkpoint/restart viable for exascale systems.

    Energy Technology Data Exchange (ETDEWEB)

    Riesen, Rolf E.; Bridges, Patrick G. (IBM Research, Ireland, Mulhuddart, Dublin); Stearley, Jon R.; Laros, James H., III; Oldfield, Ron A.; Arnold, Dorian (University of New Mexico, Albuquerque, NM); Pedretti, Kevin Thomas Tauke; Ferreira, Kurt Brian; Brightwell, Ronald Brian

    2011-09-01

    Next-generation exascale systems, those capable of performing a quintillion (10{sup 18}) operations per second, are expected to be delivered in the next 8-10 years. These systems, which will be 1,000 times faster than current systems, will be of unprecedented scale. As these systems continue to grow in size, faults will become increasingly common, even over the course of small calculations. Therefore, issues such as fault tolerance and reliability will limit application scalability. Current techniques to ensure progress across faults like checkpoint/restart, the dominant fault tolerance mechanism for the last 25 years, are increasingly problematic at the scales of future systems due to their excessive overheads. In this work, we evaluate a number of techniques to decrease the overhead of checkpoint/restart and keep this method viable for future exascale systems. More specifically, this work evaluates state-machine replication to dramatically increase the checkpoint interval (the time between successive checkpoint) and hash-based, probabilistic incremental checkpointing using graphics processing units to decrease the checkpoint commit time (the time to save one checkpoint). Using a combination of empirical analysis, modeling, and simulation, we study the costs and benefits of these approaches on a wide range of parameters. These results, which cover of number of high-performance computing capability workloads, different failure distributions, hardware mean time to failures, and I/O bandwidths, show the potential benefits of these techniques for meeting the reliability demands of future exascale platforms.

  2. Protein phosphatases acting on the replication checkpoint

    OpenAIRE

    Conde, Rui Miguel Esteves Antunes Seabra

    2010-01-01

    A génese de um cancro está dependente da acumulação de mutações genéticas que dão origem a instabilidade genómica, que por sua vez resulta na proliferação descontrolada. Para prevenir a acumulação destas mutações, as células têm mecanismos de controlo (checkpoints) que suspendem o ciclo celular e accionam as vias de reparação do ADN. Estes eventos são muitas vezes regulados por dinâmicas de (des)fosforilação de proteínas. As proteínas fosfatases (PPs), enzimas responsáveis p...

  3. Managing Adverse Events With Immune Checkpoint Agents.

    Science.gov (United States)

    Dadu, Ramona; Zobniw, Chrystia; Diab, Adi

    2016-01-01

    Immune checkpoint inhibitors (anti-cytotoxic T-lymphocyte antigen 4 and anti programmed cell death 1/programmed cell death 1 ligand antibodies) have shown impressive clinical activity in multiple cancer types. Despite achieving great clinical success, challenges and limitations of these drugs as monotherapy or various combinational strategies include the development of a unique set of immune-related adverse events (irAEs) that can be severe and even fatal. Therefore, identification of patients at risk, prevention, consistent communication between patients and medical team, rapid recognition, and treatment of irAEs are critical in optimizing treatment outcomes. This review focuses on the description of more common irAEs and provides a suggested approach for management of specific irAEs. PMID:27111908

  4. Immigration and income inequality

    DEFF Research Database (Denmark)

    Deding, Mette; Hussain, Azhar; Jakobsen, Vibeke;

    2010-01-01

    During the last two decades most Western countries have experienced increased net immigration as well as increased income inequality. This article analyzes the effects on income inequality of an increased number of immigrants in Denmark and Germany for the 20- year period 1984-2003 and how the...... impact of the increased number of immigrants differs between the two countries. We find higher inequality for immigrants than natives in Denmark but vice versa for Germany. Over the period 1984-2003, this particular inequality gap has narrowed in both countries. At the same time, the contribution of...... immigrants to overall inequality has increased, primarily caused by increased between-group inequality. The share of immigrants in the population is more important for the change in overall inequality in Denmark than in Germany, while the opposite is the case for inequality among immigrants....

  5. Targeting lung cancer through inhibition of checkpoint kinases

    OpenAIRE

    Syljuåsen, Randi G; Hasvold, Grete; Hauge, Sissel; Helland, Åslaug

    2015-01-01

    Inhibitors of checkpoint kinases ATR, Chk1, and Wee1 are currently being tested in preclinical and clinical trials. Here, we review the basic principles behind the use of such inhibitors as anticancer agents, and particularly discuss their potential for treatment of lung cancer. As lung cancer is one of the most deadly cancers, new treatment strategies are highly needed. We discuss how checkpoint kinase inhibition in principle can lead to selective killing of lung cancer cells while sparing t...

  6. A New Adaptive Checkpointing Strategy for Mobile Computing

    Institute of Scientific and Technical Information of China (English)

    MENChaoguang; ZUODecheng; YANGXiaozong

    2005-01-01

    Adaptive checkpointing strategy is an efficient recovery scheme, which is suitable for mobile computing system. However, all existing adaptive checkpointing schemes are not correct to recover system when failure occurs in some special period. In this paper, the issues that will lead to system inconsistency are first discussed and then a new adaptive strategy that can recover system to correct consistent state is proposed. Our algorithm improves system recovery performance because only failure process needs rollback through logging.

  7. A Hierarchical Checkpointing Protocol for Parallel Applications in Cluster Federations

    OpenAIRE

    Monnet, Sébastien; Morin, Christine; Badrinath, Ramamurthy

    2004-01-01

    Code coupling applications can be divided into communicating modules, that may be executed on different clusters in a cluster federation. As a cluster federation comprises of a large number of nodes, there is a high probability of a node failure. We propose a hierarchical checkpointing protocol that combines a synchronized checkpointing technique inside clusters and a communication-induced technique between clusters. This protocol fits to the characteristics of a cluster federation (large num...

  8. Cyclin-dependent kinase CDK1/CDC28 and checkpoints

    International Nuclear Information System (INIS)

    The genetic instability induced by defects in the cell cycle progression contributes to different human diseases, particularly neoplastic transformation. The control mechanisms of correct cell cycle progression are the most studied in the yeast Saccharomyces cerevisiae, in which checkpoint was first discovered. Many components of these processes have been identified by now. Here, the role of the central kinase of cell cycle CDK1/CDC28 is considered in checkpoint in different phases.

  9. DMTCP: bringing interactive checkpoint-restart to Python

    Science.gov (United States)

    Arya, Kapil; Cooperman, Gene

    2015-01-01

    DMTCP (Distributed MultiThreaded CheckPointing) is a mature checkpoint-restart package. It operates in user space without kernel privilege, and adapts to application-specific requirements through plugins. While DMTCP has been able to checkpoint Python and IPython ‘from the outside’ for many years, a Python module has recently been created to support DMTCP. IPython support is included through a new DMTCP plugin. A checkpoint can be requested interactively within a Python session or under the control of a specific Python program. Further, the Python program can execute specific Python code prior to checkpoint, upon resuming (within the original process) and upon restarting (from a checkpoint image). Applications of DMTCP are demonstrated for: (i) Python-based graphics using virtual network client, (ii) a fast/slow technique to use multiple hosts or cores to check one (Cython Behnel S et al 2011 Comput. Sci. Eng. 13 31-39) computation in parallel, and (iii) a reversible debugger, FReD, with a novel reverse-expression watchpoint feature for locating the cause of a bug.

  10. A survey of checkpointing algorithms for parallel and distributed computers

    Indian Academy of Sciences (India)

    S Kalaiselvi; V Rajaraman

    2000-10-01

    Checkpoint is defined as a designated place in a program at which normal processing is interrupted specifically to preserve the status information necessary to allow resumption of processing at a later time. Checkpointing is the process of saving the status information. This paper surveysthe algorithms which have been reported in the literature for checkpointing parallel/distributed systems. It has been observed that most of the algorithms published for checkpointing in message passing systems are based on the seminal article by Chandy and Lamport. A large number of articles have been published in this area by relaxing the assumptions made in this paper and by extending it to minimise the overheads of coordination and context saving. Checkpointing for sharedmemory systems primarily extend cache coherence protocolstomaintain a consistent memory. All of them assume that the main memory is safe for storing the context. Recently algorithms have been published for distributed shared memory systems, which extend the cache coherence protocols used in shared memory systems. They however also include methods for storing the status of distributed memory in stable storage. Most of the algorithms assume that there is no knowledge about the programs being executed.It is howeverfelt that in development of parallel programs the user has to do a fair amount of work in distributing tasks and this information can be effectively used to simplify checkpointing and rollback recovery.

  11. An Analysis of Checkpointing Algorithms for Distributed Mobile Systems

    Directory of Open Access Journals (Sweden)

    Ajay Khunteta

    2010-07-01

    Full Text Available Distributed snapshots are an important building block for distributed systems, and are useful for constructing efficient checkpointing protocols, among other uses. Direct application of these algorithms to mobile systems is not easible, however, due to differences in the environment in which mobile systems operate, relative to general distributed systems. The mobile computing environment introduces newchallenges in the area of fault-tolerant computing. Compared to traditional distributed environments, wireless networks are typically slower, providing lower throughput and latency, comparing to wireline networks. In addition, the mobile hosts have limited computation esources, are often exposed to harsh operating environment that makes them more likely to fail, and can roam while operating. Over the past two decades, intensive research work has been carried out on providing efficient checkpointing protocols in traditional distributed computing. Recently, more attention has been paid to providing checkpointing protocols for mobile systems. Some of these protocols have been adapted from the traditional distributed environment; others have been created from scratch for mobile systems. Checkpoint is defined as a designated place in a program at which normal processing is interrupted specifically to preserve the status information necessary to allow resumption of processing at alater time. Checkpointing is the process of saving the status information. This paper surveys the algorithms which have been reported in the literature for checkpointing in Mobile Distributed systems.

  12. A Tunable Checkpointing Algorithm for Distributed Mobile Applications

    Directory of Open Access Journals (Sweden)

    Sungchae Lim

    2011-11-01

    Full Text Available The aim of a distributed checkpointing algorithm is to efficiently restore the execution state of distributed applications in face of hardware or software failures. Originally, such algorithms were devised for fixed networking systems, of which computing components communicate with each other via wired networks. Therefore, those algorithms usually suffer from heavy networking costs coming from frequent data transits over wireless networks, if they are used in the wireless computing environment. In this paper, to reduce usage of wireless communications, our checkpointing algorithm allows the distributed mobile application to tune the level of its checkpointing strictness. The strictness is defined by the maximum rollback distance (MRD that says how many recent local checkpoints can be rolled back in the worst case. Since our algorithm have more flexibility in checkpointing schedule due to the use of MRD, it is possible to reduce the number of enforced local checkpointing. In particular, the amount of data transited on wirelesses networks becomes smaller than in earlier methods; thus, our algorithm provides less communication cost and shortened blocking time.

  13. Raja Junankar, Economics of Immigration: Immigration and the Australian Economy

    OpenAIRE

    DOUGLAS, Kacey

    2016-01-01

    Abstract. The Economics of Immigration: Immigration and the Australian Economy is a compilation of academic articles written by P.N. Junankar and coauthors on the topic of immigration in Australia. From the effects of immigration on Australia’s economy to the Australian labor market environment immigrants encounter, this book addresses important questions regarding immigration that are relevant to any economy.Keywords. Australia, International migration, International economics.JEL. F00, F22,...

  14. Workplace Concentration of Immigrants

    OpenAIRE

    Monica I. Garcia-Perez; Fredrik Andersson; John Haltiwanger; Fredrik Kristin McCue; Seth Sanders

    2014-01-01

    To what extent do immigrants and the native-born work in separate workplaces? Do worker and firm characteristics explain the degree of workplace concentration? We explore these questions using a matched employer-employee database that extensively covers employers in selected MSAs. We find that immigrants are much more likely to have immigrant coworkers than are natives, and are particularly likely to work with their compatriots. We find much higher levels of concentration for small businesses...

  15. Do immigrants cause crime?

    OpenAIRE

    Bianchi, Milo; Buonanno, Paolo; Pinotti, Paolo

    2008-01-01

    In this paper we examine the empirical relationship between immigration and crime across Italian provinces during the period 1990-2003. Drawing on police administrative data, we first document that the size of immigrant population is positively correlated with the incidence of property crimes and with the overall crime rate. Then, we use instrumental variables based on migration toward other European countries to identify the causal impact of exogenous changes of immigrant population in Italy...

  16. Do Immigrants Cause Crime?

    OpenAIRE

    Bianchi, Milo; Buonanno, Paolo; Pinotti, Paolo

    2012-01-01

    International audience We examine the empirical relationship between immigration and crime across Italian provinces during the period 1990-2003. Drawing on police administrative records, we first document that the size of the immigrant population is positively correlated with the incidence of property crimes and with the overall crime rate. Then, we use instrumental variables based on immigration toward destination countries other than Italy to identify the causal impact of exogenous chang...

  17. Culture And Adult Immigrants

    OpenAIRE

    Andersen, Tamar Barbara; Fogde, Anne-Sofie; Rasmussen, Ditte Ninna; Uski, Juha Janne Olavi

    2005-01-01

    "Culture and adult immigrants" is a project about integration of adult immigrants into the Danish society. It is based on an integration theory by Charlotte Hamburger and a culture theory by Thomas Hylland Eriksen and Torunn Arntsen Sørheim. The two theories conclude in a joined analysis of language school material from the language centre of Roskilde, in search for an answer to the question if and how the Danish language education supports the integration of adult immigrants into the D...

  18. Immigrants and entrepreneurship

    OpenAIRE

    Lofstrom, Magnus

    2014-01-01

    Immigrants are widely perceived to be highly entrepreneurial, contributing to economic growth and innovation, and self-employment is often viewed as a means of enhancing labor market integration and success among immigrants. Accordingly, many countries have established special visas and entry requirements to attract immigrant entrepreneurs. Research supports some of these stances, but expectations may be too high. There is no strong evidence that self-employment is an effective tool of upward...

  19. Occupational Adjustment of Immigrants

    OpenAIRE

    Zorlu, Aslan

    2011-01-01

    This paper examines the speed of the occupational adjustment of immigrants using Labour Force Surveys 2004 and 2005 from Statistics Netherlands. The analysis provides new evidence that immigrants start with jobs at the lower levels of skill distribution. Their occupational achievement improves significantly with the duration of residence. The extent of this initial disadvantage and the rate of adjustment vary across immigrant groups according to the transferability of skills associated with t...

  20. Can Immigrants Hurt Trade?

    OpenAIRE

    Tomas Konecny

    2007-01-01

    This paper estimates the impact of immigrant network spillovers on international trade. Contrary to previous studies focusing mostly on the trade enhancing role of immigrant networks, the present framework allows for potential trade diverting effects. A simple matching model that incorporates both trade creation and diversion channels furthermore points at the importance of relative as opposed to absolute measures of immigrant networks. Using a new dataset of 19 OECD countries, I find that wh...

  1. Libertarianism and Immigration

    OpenAIRE

    Diana Virginia Todea

    2010-01-01

    In this paper I investigate the libertarian account of immigration. In the first section I distinguish between right-libertarianism and left-libertarianism. In the second section I analyze the arguments focused on immigration from the perspective of self-ownership focused on Nozick’s case and Steiner’s analogy. In the third section I discuss the conflict between the collective consent on the issue of immigration and the individuals’ decision. The conclusion sets the libertarian framework as b...

  2. Prejudice and Immigration

    OpenAIRE

    Paolo E. Giordani; Michele Ruta

    2008-01-01

    We study immigration policy in a small open receiving economy under self-selection of migrants. We show that immigration policy choice affects and is affected by the migratory decisions of skilled and unskilled foreign workers. From this interaction multiple equilibria may arise, which are driven by the natives' expectations on the migrants' size and skill composition (and, hence, on the welfare effects of immigration). In particular, pessimistic (optimistic) beliefs induce a country to impos...

  3. Immigration and native welfare

    OpenAIRE

    Gabriel J. Felbermayr; Kohler, Wilhelm

    2004-01-01

    We unify two approaches towards identifying native welfare effects of immigration, one emphasizing the immigration surplus (Borjas, 1995,1999), the other identifying a welfare loss due to terms-of-trade effects (Davis & Weinstein, 2002). We decompose the native welfare effect of immigration into the standard complementarity effect, augmented by a Stolper-Samuelson effect, and a terms-of-trade effect. Using a structural model with three skill-classes we derive propositions on the wage and nati...

  4. Review of Some Checkpointing Schemes for Distributed and Mobile Computing Environments

    Directory of Open Access Journals (Sweden)

    Mr Raman Kumar

    2015-05-01

    Full Text Available Fault Tolerance Techniques facilitate systems to carry out tasks in the incidence of faults. A checkpoint is a local state of a process saved on stable storage. In a distributed system, since the processes in the system do not share memory; a global state of the system is defined as a combination of local states, one from each process. In case of a fault in distributed systems, checkpointing enables the execution of a program to be resumed from a previous consistent global state rather than resuming the execution from the commencement. In this way, the sum of constructive processing vanished because of the fault is appreciably reduced. In this paper, we talk about various issues related to the checkpointing for distributed systems and mobile computing environments. We also confer various types of checkpointing: coordinated checkpointing, asynchronous checkpointing, communication induced checkpointing and message logging based checkpointing. We also present a survey of some checkpointing algorithms for distributed systems.

  5. The integration of immigrants

    OpenAIRE

    Bauböck, Rainer

    1995-01-01

    from the Table of Contents: Migration and integration - Basic concepts and definitions; Immigration and Integration policies; The legal framework for integration; Dimension of social integration; Cultural integration; Conclusions;

  6. Workplace concentration of immigrants.

    Science.gov (United States)

    Andersson, Fredrik; García-Pérez, Mónica; Haltiwanger, John; McCue, Kristin; Sanders, Seth

    2014-12-01

    Casual observation suggests that in most U.S. urban labor markets, immigrants have more immigrant coworkers than native-born workers do. While seeming obvious, this excess tendency to work together has not been precisely measured, nor have its sources been quantified. Using matched employer-employee data from the U.S. Census Bureau Longitudinal Employer-Household Dynamics (LEHD) database on a set of metropolitan statistical areas (MSAs) with substantial immigrant populations, we find that, on average, 37 % of an immigrant's coworkers are themselves immigrants; in contrast, only 14 % of a native-born worker's coworkers are immigrants. We decompose this difference into the probability of working with compatriots versus with immigrants from other source countries. Using human capital, employer, and location characteristics, we narrow the mechanisms that might explain immigrant concentration. We find that industry, language, and residential segregation collectively explain almost all the excess tendency to work with immigrants from other source countries, but they have limited power to explain work with compatriots. This large unexplained compatriot component suggests an important role for unmeasured country-specific factors, such as social networks. PMID:25425452

  7. Berkeley lab checkpoint/restart (BLCR) for Linux clusters

    Science.gov (United States)

    Hargrove, Paul H.; Duell, Jason C.

    2006-09-01

    This article describes the motivation, design and implementation of Berkeley Lab Checkpoint/Restart (BLCR), a system-level checkpoint/restart implementation for Linux clusters that targets the space of typical High Performance Computing applications, including MPI. Application-level solutions, including both checkpointing and fault-tolerant algorithms, are recognized as more time and space efficient than system-level checkpoints, which cannot make use of any application-specific knowledge. However, system-level checkpointing allows for preemption, making it suitable for responding to ''fault precursors'' (for instance, elevated error rates from ECC memory or network CRCs, or elevated temperature from sensors). Preemption can also increase the efficiency of batch scheduling; for instance reducing idle cycles (by allowing for shutdown without any queue draining period or reallocation of resources to eliminate idle nodes when better fitting jobs are queued), and reducing the average queued time (by limiting large jobs to running during off-peak hours, without the need to limit the length of such jobs). Each of these potential uses makes BLCR a valuable tool for efficient resource management in Linux clusters.

  8. Message Efficient Checkpointing and Rollback Recovery in Heterogeneous Mobile Networks

    Science.gov (United States)

    Jaggi, Parmeet Kaur; Singh, Awadhesh Kumar

    2016-06-01

    Heterogeneous networks provide an appealing way of expanding the computing capability of mobile networks by combining infrastructure-less mobile ad-hoc networks with the infrastructure-based cellular mobile networks. The nodes in such a network range from low-power nodes to macro base stations and thus, vary greatly in their capabilities such as computation power and battery power. The nodes are susceptible to different types of transient and permanent failures and therefore, the algorithms designed for such networks need to be fault-tolerant. The article presents a checkpointing algorithm for the rollback recovery of mobile hosts in a heterogeneous mobile network. Checkpointing is a well established approach to provide fault tolerance in static and cellular mobile distributed systems. However, the use of checkpointing for fault tolerance in a heterogeneous environment remains to be explored. The proposed protocol is based on the results of zigzag paths and zigzag cycles by Netzer-Xu. Considering the heterogeneity prevalent in the network, an uncoordinated checkpointing technique is employed. Yet, useless checkpoints are avoided without causing a high message overhead.

  9. Berkeley lab checkpoint/restart (BLCR) for Linux clusters

    International Nuclear Information System (INIS)

    This article describes the motivation, design and implementation of Berkeley Lab Checkpoint/Restart (BLCR), a system-level checkpoint/restart implementation for Linux clusters that targets the space of typical High Performance Computing applications, including MPI. Application-level solutions, including both checkpointing and fault-tolerant algorithms, are recognized as more time and space efficient than system-level checkpoints, which cannot make use of any application-specific knowledge. However, system-level checkpointing allows for preemption, making it suitable for responding to ''fault precursors'' (for instance, elevated error rates from ECC memory or network CRCs, or elevated temperature from sensors). Preemption can also increase the efficiency of batch scheduling; for instance reducing idle cycles (by allowing for shutdown without any queue draining period or reallocation of resources to eliminate idle nodes when better fitting jobs are queued), and reducing the average queued time (by limiting large jobs to running during off-peak hours, without the need to limit the length of such jobs). Each of these potential uses makes BLCR a valuable tool for efficient resource management in Linux clusters

  10. The blockade of immune checkpoints in cancer immunotherapy

    Science.gov (United States)

    Pardoll, Drew M.

    2016-01-01

    Among the most promising approaches to activating therapeutic antitumour immunity is the blockade of immune checkpoints. Immune checkpoints refer to a plethora of inhibitory pathways hardwired into the immune system that are crucial for maintaining self-tolerance and modulating the duration and amplitude of physiological immune responses in peripheral tissues in order to minimize collateral tissue damage. It is now clear that tumours co-opt certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumour antigens. Because many of the immune checkpoints are initiated by ligand–receptor interactions, they can be readily blocked by antibodies or modulated by recombinant forms of ligands or receptors. Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) antibodies were the first of this class of immunotherapeutics to achieve US Food and Drug Administration (FDA) approval. Preliminary clinical findings with blockers of additional immune-checkpoint proteins, such as programmed cell death protein 1 (PD1), indicate broad and diverse opportunities to enhance antitumour immunity with the potential to produce durable clinical responses. PMID:22437870

  11. 10 Myths about Immigration

    Science.gov (United States)

    Teaching Tolerance, 2011

    2011-01-01

    Myths about immigration and immigrants are common. This article presents a few of the most frequently heard misconceptions, along with information to help teachers and their students separate fact from fear. Teachers should debunk the misinformation students bring to school--and help them think for themselves. They must guide students to find a…

  12. Irelands' Immigrant Children

    Science.gov (United States)

    Culleton, Jonathan

    2004-01-01

    In industrialised Western nations generally, and European Union (EU) nations particularly, immigration is an issue of considerable concern and debate. In the EU, however, discussion of immigration has tended to centre on a number of policy issues, from reliance on welfare provision, to labour force participation, to healthcare provision, to…

  13. Immigration: Coming to America

    Science.gov (United States)

    Anderson, Kristin

    2011-01-01

    To say that immigration is currently a controversial issue would be an understatement. The media is rife with misinformation and does a very poor job of making the critical distinction between legal and illegal immigration. Because of this, it is vitally important that libraries provide students with clear and unbiased material on the topic. In…

  14. "A Day Without Immigrants"

    DEFF Research Database (Denmark)

    Heiskanen, Benita

    2009-01-01

    Abstract This article considers the debates surrounding the "Day Without Immigrants" protests organized in major U.S. cities on 1 May 2006, prompted by H.R. 4437, the Border Protection, Anti-Terrorism, and Illegal Immigration Control Act of 2005, from the multiple perspectives of scholars, pundits...

  15. Encounters with immigrant customers

    DEFF Research Database (Denmark)

    Mygind, Anna; Espersen, Sacha; Nørgaard, Lotte Stig;

    2013-01-01

    OBJECTIVES: To explore the challenges that Danish community pharmacy staff encounter when serving non-Western immigrant customers. Special attention was paid to similarities and differences between the perceptions of pharmacists and pharmacy assistants. METHODS: A questionnaire was distributed...... to one pharmacist and one pharmacy assistant employed at each of the 55 community pharmacies located in the five local councils in Denmark with the highest number of immigrant inhabitants. KEY FINDINGS: The total response rate was 76% (84/110). Most respondents found that the needs of immigrant customers...... interval, CI, 1.27-8.04). Forty-two per cent (n = 35) perceived that immigrant customers put pressure on pharmacy staff resources, while 27% (n = 23) found that the immigrant customer group make work more interesting. More pharmacists than assistants agreed on the latter (OR, 3.43; 95% CI, 1...

  16. Holdninger til immigration

    DEFF Research Database (Denmark)

    Malchow-Møller, Nikolaj; Munch, Jakob Roland; Schroll, Sanne;

    Denne artikel belyser holdninger til immigration blandt borgere i Danmark og de øvrige EU-15 lande - herunder holdningerne til immigration, der følger af den seneste EU-udvidelse. Det analyseres, hvilke faktorer der ligger til frund for disse holdninger, samt i hvilken udstrækning danskere afviger...... fra EU-gennemsnittet. Den typiske dansker er lidt mere skeptisk overfor immigration end andre europæere. Danskerne afskiller sig desuden ved, at forholdsvis få forbinder øget immigration med negative konsekvenser for arbejdsmarkedet, men forholdsvis mange forbinder det med højere omkostninger for...... velfærdsstaten. Når der tages hensyn til opfattelserne af de økonomiske konsekvenser af immigration, kommer Danmark til at fremstå som et væsentligt mere immigrationsskeptisk land, end hvad der kommer til udtryk i de ukorrigerede holdninger...

  17. Holdninger til Immigration

    DEFF Research Database (Denmark)

    Malchow-Møller, Nikolaj; Roland Munch, Jakob; Schroll, Sanne;

    2006-01-01

    Denne artikel belyser holdninger til immigration blandt borgere i Danmark og de øvrige EU-15 lande - herunder holdningerne til immigration, der følger af den seneste EU-udvidelse. Det analyseres, hvilke faktorer der ligger til frund for disse holdninger, samt i hvilken udstrækning danskere afviger...... fra EU-gennemsnittet. Den typiske dansker er lidt mere skeptisk overfor immigration end andre europæere. Danskerne afskiller sig desuden ved, at forholdsvis få forbinder øget immigration med negative konsekvenser for arbejdsmarkedet, men forholdsvis mange forbinder det med højere omkostninger for...... velfærdsstaten. Når der tages hensyn til opfattelserne af de økonomiske konsekvenser af immigration, kommer Danmark til at fremstå som et væsentligt mere immigrationsskeptisk land, end hvad der kommer til udtryk i de ukorrigerede holdninger....

  18. Checkpoint Inhibitors for the Treatment of Hodgkin Lymphoma.

    Science.gov (United States)

    Bennani-Baiti, Nabila; Thanarajasingam, Gita; Ansell, Stephen

    2016-06-01

    Hodgkin lymphoma's (HL) tumor composition is characterized by a paucity of malignant cells and a preponderance of immune and stromal cells. Despite the rich immune milieu within the tumor microenvironment, malignant cells are able to effectively evade the immune system and use immune support to promote lymphoma cell growth and proliferation. Recognizing this has led to the identification of checkpoint inhibitory signals that enable immune evasion and to opening the door to therapeutic strategies on how to exploit the immune system in targeting tumor cells. We discuss herein some of the tumor evasion mechanisms in HL with a particular focus on the immune checkpoint pathways and focus on recent clinical data of checkpoint blockade in HL treatment. PMID:26818843

  19. Immune checkpoint blockade therapy for bladder cancer treatment.

    Science.gov (United States)

    Kim, Jayoung

    2016-06-01

    Bladder cancer remains the most immunogenic and expensive malignant tumor in the United States today. As the 4th leading cause of death from cancer in United States, Immunotherapy blocking immune checkpoints have been recently been applied to many aggressive cancers and changed interventions of urological cancers including advanced bladder cancer. The applied inhibition of PD-1-PD-L1 interactions can restore antitumor T-cell activity and enhance the cellular immune attack on antigens. The overall goals of this short review article are to introduce current cancer immunotherapy and immune checkpoint inhibitors, and to provide new insight into the underlying mechanisms that block immune checkpoints in tumor microenvironment. Furthermore, this review will address the preclinical and clinical trials to determine whether bladder cancer patients could benefit from this new cancer therapy in near future. PMID:27326412

  20. Voting over Selective Immigration Policies with Immigration Aversion

    OpenAIRE

    Russo, Giuseppe

    2008-01-01

    The claim that "skilled immigration is welcome" is often associated to the increasing adoption of selective immigration policies. I study the voting over differentiated immigration policies in a two-country, three-factor one-period model where there exist skilled and unskilled workers, migration decisions are endogenous, enforcing immigration restriction is costly, and natives dislike unskilled immigration. According to my findings, decisions over border closure are made to protect the median...

  1. Voting over Selective Immigration Policies with Immigration Aversion

    OpenAIRE

    Russo, Giuseppe

    2008-01-01

    The claim that "skilled immigration is welcome" is often associated to the increasing adoption of selective immigration policies. I study the voting over differentiated immigration policies in a two-country, three-factor general equilibrium model where there exist skilled and unskilled workers, migration decisions are endogenous, enforcing immigration restriction is costly, and natives dislike unskilled immigration. According to my findings, decisions over border closure are made to protect t...

  2. The Human Face of Immigration

    Science.gov (United States)

    Costello, Maureen

    2011-01-01

    In the past, nativists opposed immigration, period. The sharp distinction between "legal" and "illegal" immigrants emerged fairly recently, according to immigration historian David Reimers, a professor of history at New York University. "Basically, by the mid-90s 'legal' immigration was no longer an issue," he says. "The hot-button issue became…

  3. Empower Educators to Teach Immigration

    Science.gov (United States)

    Burnett, Sara; Kugler, Eileen Gale; Tesh, Claire

    2016-01-01

    Over the past decades, U.S. immigration has changed significantly, yet the way we teach about immigration in schools has changed little. The American Immigration Council has developed a two-year program on Long Island, an area experiencing an increase of new arrivals and anti-immigrant sentiment. The program empowers teachers with the knowledge to…

  4. Low-Overhead Non-Blocking Checkpointing Scheme for Mobile Computing Systems

    Institute of Scientific and Technical Information of China (English)

    MEN Chaoguang; CAO Liujuan; WANG Liwen; XU Zhenpeng

    2007-01-01

    When applied to mobile computing systems, checkpoint protocols for distributed computing systems would face many new challenges, such as low wireless bandwidth, frequent disconnections, and lack of stable storage at mobile hosts. This paper proposes a novel checkpoint protocol to effectively reduce the coordinating overhead. By using a communication vector, only a few processes participate in the checkpointing event. During checkpointing, the scheme can save the time used to trace the dependency tree by sending checkpoint requests to dependent processes at once. In addition, processes are non-blocking in this scheme, since the inconsistency is resolved by the piggyback technique. Hence the unnecessary and orphan messages can be avoided. Compared with the traditional coordinated checkpoint approach, the proposed non-blocking algorithm obtains a minimal number of processes to take checkpoints. It also reduces the checkpoint latency, which brings less overhead to mobile host with limited resources.

  5. Keeping it together in times of stress: checkpoint function at stalled replication forks

    OpenAIRE

    Berens, Theresa J.; David P Toczyski

    2012-01-01

    In this issue, De Piccoli et al. (2012) show that, contrary to current models of DNA replication checkpoint function, replication proteins remain associated with each other and with replicating DNA when replication is stressed in checkpoint-deficient cells.

  6. Overeducation among immigrants in Sweden

    DEFF Research Database (Denmark)

    Andersson Joona, Pernilla; Datta Gupta, Nabanita; Wadensjo, Eskil

    2014-01-01

    The utilization and reward of the human capital of immigrants in the labor market of the host country has been studied extensively. Using Swedish register data from 2001–2008, we extend the immigrant educational mismatch literature by analyzing incidence, wage effects and state dependence in...... overeducation among natives and immigrants. In line with previous research we find a higher incidence and a lower return to overeducation among immigrants indicating that immigrants lose more from being overeducated. We find a high degree of state dependence in overeducation both among natives and immigrants......, but considerably higher among immigrants....

  7. Immigration and the Dutch economy

    OpenAIRE

    Hans Roodenburg; Rob Euwals; Harry ter Rele

    2003-01-01

    For some time now, immigration has been high on the national and international agenda. In addition to the legal, humanitarian and social aspects, the economic impact of immigration is receiving increasing attention. Read also the accompanying press release . What costs and benefits of immigration accrue to the host country? How can immigration and integration policies be modified so as to improve the balance? Is immigration an effective instrument in alleviating the burden of ageing? What can...

  8. Immigrant Teachers in Australia

    Directory of Open Access Journals (Sweden)

    Jock Collins

    2012-11-01

    Full Text Available One of the features of contemporary society is the increasing global mobility of professionals. While the education industry is a key site of the demand for contemporary global professional migration, little attention has been given to the global circulation of education professionals. Over past decades, immigrant teachers have been an important component of skilled and professional immigration into Australia, there is no comprehensive contemporary national study of the experiences of immigrant teachers in Australia. This article aims to fill this gap and to answer questions about their decision to move to Australia, their experience with Australian Education Departments in getting appointed to a school, their experiences as teachers in the classroom and in their new Australian community. It draws on primary data sources - in the form of a survey of 269 immigrant teachers in schools in NSW, SA and WA conducted in 2008-9 - and secondary sources - in the form of the 2006 national census and Longitudinal Survey of Immigrants in Australia – to provide insights into immigrant teachers in Australian schools, adding also to our understanding of Australia’s contemporary immigration experience.

  9. [Antenatal care in immigrants].

    Science.gov (United States)

    de la Torre, J; Coll, C; Coloma, M; Martín, J I; Padrón, E; González González, N L

    2006-01-01

    The phenomenon of immigration has had an impact on the health care of the population. The immigrant population in Spain today represents approximately 8% of the total population. The majority of this population proceeds from countries with low income, and its origin and distribution is diverse. The immigrant population is characterised by its being young and healthy, and with a capacity to adapt to changes, but its social, economic and labour conditions are frequently insecure and favour vulnerability to disease. In spite of the number of immigrants of the male sex being globally higher than that of women, the percentage of immigrants of the female sex is growing. This increase of the female immigrant population has resulted in the appearance of specific health care needs, especially with respect to sexual and reproductive health. To which we must add a substantial increase in pathologies prevalent in the countries of origin, such as anaemia, tuberculosis, malnutrition, haemoglobinopathies, consanguinity, hypocalcaemia, hepatitis B and/or C, sexually transmitted infections, infectious diseases transmitted by arthropods, such as Chagas disease and other parasitoses, as well as genital mutilations. The aim of this article is to analyse the factors that make it difficult to control gestation in the immigrant population, as well as to establish guidelines for acting in antenatal care consultations. Insistence is placed on health education and prevention during pregnancy, and consideration is given to the appearance of rare diseases related to some of these groups. PMID:16721417

  10. How integrated are immigrants?

    Directory of Open Access Journals (Sweden)

    Rickard Sandell

    2015-12-01

    Full Text Available Background: The successful integration of immigrants is seen as a principal means to secure economic growth and welfare in many countries. Success in this task depends on the capacity to formulate effective integration policies, which in turn is based on research capable of describing and explaining the integration process properly. Objective: Our objective is to define a conceptual and quantifiable measure of full immigrant integration.This enables a quantitative evaluation of how integrated immigrants are in a specific context in an immigrant - native system - a question poorly addressed by past research. Methods: Our approach consists of looking at the functional dependency of different integrationquantifiers on immigrant density. The empirical analysis uses register data from Spain. We focus on social integration and labour market integration in formal employment. Results: In our empirical analysis we find dramatic differences in immigrant integration levels across integration contexts. While labour market integration approaches the level of full integration, social integration quickly declines as immigration levels surge. It is shown that these differences are primarily due to the presence of social network effects in the social integration process, absent in the labour market integration process. Conclusions: Proper identification of integration deficits and its causes is likely to improve the efficiency of integration policy making, and the capacity to reach integration targets. Our framework has this quality. The research presented here shows that full labour market integration of immigrants is a realistic target. However, it also shows that, if left unattended, the segregation forces contained in social networks, quite dramatically obstruct the social integration process. Lack of social integration undermines the strategy of reliance on increasing immigration to secure future economic well-being that many governments andinternational

  11. Toward immigration reform.

    Science.gov (United States)

    Franken, Mark

    2005-01-01

    For the most part, immigrants in the United States do not have access to the very safety-net benefits supported by their taxes, nor to essential due-process rights, simply because they are not citizens or legal residents. Contemporary demographics of immigration and post-9/11 security concerns have colored our traditional hospitality as a nation of immigrants and made life more difficult for immigrants. The Catholic Church has a rich history of scriptural and social teaching that addresses the question of immigration. Stories of forced migration in the Pentateuch led to commandments regarding strangers and the responsibility to be welcoming. In the New Testament, we see that the Holy Family themselves were refugees. The Gospel of St. Matthew tells us that we will be judged by the way we respond to migrants and others in need. In Exsul Familia, Pope Pius XII reaffirms the commitment of the church to care for pilgrims, aliens, exiles, and migrants. In Ecclesia in America, Pope John Paul II states that the ultimate solution to illegal immigration is the elimination of global underdevelopment and that, in the meantime, the human rights of all migrants must be respected. In 2003, the bishops of Mexico and the United States jointly issued the pastoral letter Strangers No Longer: Together on the Journey of Hope. In this letter, the bishops say that U.S. immigration policy should protect the human rights and dignity of immigrants and asylum seekers. The bishops also offer a number of proposed public policy responses toward that end. To advance the principles contained in Strangers No Longer, the bishops have decided to mount a national campaign designed to unite and mobilize a growing network of Catholic organizations and individuals, as well as others of good faith. In addition, the campaign will seek to dispel myths and misperceptions about immigrants. PMID:15693224

  12. S&E immigration

    Science.gov (United States)

    Despite an overall decline in immigration to the United States in 1993, the number of scientists and engineers (S&Es) entering the country continued to rise, with women representing 21.3% of the total admitted with permanent resident status. According to the Immigration and Naturalization Service, 23,534 S&Es were admitted to the United States on permanent visas in 1993, 3.1% more than in 1992. Of that total, 5,020 were women. S&Es made up 2.6% of the total U.S. immigration in 1993. The slight 1993 increase followed a large jump in 1992 of 62% over the previous year.

  13. Immigration measures, 1988.

    Science.gov (United States)

    1988-01-01

    In 1988, the Government of Norway undertook the following immigration measures: 1) it merged the Office of Immigration, which deals with asylum matters, and the Government Refugee Agency, which handles reception and settlement, into a new Directorate for Immigration under the Ministry of Local Government and Labour; 2) it instituted visa requirements for Chileans; and 3) it established a new reception program, under which five regional reception centers are to be created accommodating 200 to 300 people each, where asylum seekers will be placed until they have completed their police interview and a municipality has agreed to accept them. PMID:12289341

  14. Attitudes Towards Immigration

    DEFF Research Database (Denmark)

    Malchow-Møller, Nikolaj; Roland Munch, Jakob; Schroll, Sanne;

    2006-01-01

    In this paper, we re-examine the role of economic self-interest in shaping people's attitudes towards immigration, using data from the European Social Survey 2002/2003. Compared to the existing literature, there are two main contributions of the present paper. First, we develop a more powerful test...... of the hypothesis that a positive relationship between education and attitudes towards immigration reflects economic self-interest in the labour market. Second, we develop an alternativeand more direct test of whether economic self-interest mattersfor people's attitudes towards immigration. We find...

  15. Attitudes Towards Immigration

    DEFF Research Database (Denmark)

    Malchow-Møller, Nikolaj; Munch, Jakob Roland; Schroll, Sanne;

    In this paper, we re-examine the role of economic self-interest in shaping people’s attitudes towards immigration, using data from the European Social Survey 2002/2003. Compared to the existing literature, there are two main contributions of the present paper. First, we develop a more powerful test...... of the hypothesis that a positive relationship between education and attitudes towards immigration reflects economic self-interest in the labour market. Second, we develop an alternative and more direct test of whether economic self-interest matters for people’s attitudes towards immigration. We find...

  16. The New Immigrant Ethic

    Institute of Scientific and Technical Information of China (English)

    Kwame; Dougan

    2011-01-01

    AMY Chua’s parenting is grounded in a fear of failure,but her authoritarian style is no more exclusively Chinese than rice is:it can be found operating, to varying degrees of rigor,in most homes of recently arrived - and relatively poor - immigrants. I call this take-no-prisoners type of parenting the "new immigrant ethic." And as a black African immigrant to the West,I overcame significant odds,odds that don’t factor in Chua’s life and her Chinese-mother parenting model.

  17. Immigration Policy, Assimilation of Immigrants, and Natives' Sentiments Towards Immigrants: Evidence from 12 OECD Countries

    OpenAIRE

    Bauer, Thomas K.; Lofstrom, Magnus; Zimmermann, Klaus F.

    2001-01-01

    As in the U.S. and Canada, migration is a controversial issue in Europe. This paper explores the possibility that immigration policy may affect the labor market assimilation of immigrants and hence natives’ sentiments towards immigrants. It first reviews the assimilation literature in economics and the policy approaches taken in Europe and among the traditional immigration countries. Second, a new analysis of individual data from the OECD countries studies sentiments concerning immigration an...

  18. Immune-Checkpoint Blockade and Active Immunotherapy for Glioma

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Brian J. [Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 (United States); Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 (United States); Pollack, Ian F. [Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 (United States); Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 (United States); Okada, Hideho, E-mail: okadah@upmc.edu [Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 (United States); Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 (United States); Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 (United States); Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 (United States)

    2013-11-01

    Cancer immunotherapy has made tremendous progress, including promising results in patients with malignant gliomas. Nonetheless, the immunological microenvironment of the brain and tumors arising therein is still believed to be suboptimal for sufficient antitumor immune responses for a variety of reasons, including the operation of “immune-checkpoint” mechanisms. While these mechanisms prevent autoimmunity in physiological conditions, malignant tumors, including brain tumors, actively employ these mechanisms to evade from immunological attacks. Development of agents designed to unblock these checkpoint steps is currently one of the most active areas of cancer research. In this review, we summarize recent progresses in the field of brain tumor immunology with particular foci in the area of immune-checkpoint mechanisms and development of active immunotherapy strategies. In the last decade, a number of specific monoclonal antibodies designed to block immune-checkpoint mechanisms have been developed and show efficacy in other cancers, such as melanoma. On the other hand, active immunotherapy approaches, such as vaccines, have shown encouraging outcomes. We believe that development of effective immunotherapy approaches should ultimately integrate those checkpoint-blockade agents to enhance the efficacy of therapeutic approaches. With these agents available, it is going to be quite an exciting time in the field. The eventual success of immunotherapies for brain tumors will be dependent upon not only an in-depth understanding of immunology behind the brain and brain tumors, but also collaboration and teamwork for the development of novel trials that address multiple layers of immunological challenges in gliomas.

  19. The absence of a DNA replication checkpoint in porcine zygotes

    Czech Academy of Sciences Publication Activity Database

    Vacková, I.; Křen, Radomír; Loi, P.; Krylov, V.; Fulka Jr., J.

    2006-01-01

    Roč. 14, 1 (2006), s. 33-37. ISSN 0967-1994 Institutional research plan: CEZ:AV0Z50450515 Keywords : checkpoint * DNA replication * fertilization Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.782, year: 2006

  20. Immune-Checkpoint Blockade and Active Immunotherapy for Glioma

    Directory of Open Access Journals (Sweden)

    Brian J. Ahn

    2013-11-01

    Full Text Available Cancer immunotherapy has made tremendous progress, including promising results in patients with malignant gliomas. Nonetheless, the immunological microenvironment of the brain and tumors arising therein is still believed to be suboptimal for sufficient antitumor immune responses for a variety of reasons, including the operation of “immune-checkpoint” mechanisms. While these mechanisms prevent autoimmunity in physiological conditions, malignant tumors, including brain tumors, actively employ these mechanisms to evade from immunological attacks. Development of agents designed to unblock these checkpoint steps is currently one of the most active areas of cancer research. In this review, we summarize recent progresses in the field of brain tumor immunology with particular foci in the area of immune-checkpoint mechanisms and development of active immunotherapy strategies. In the last decade, a number of specific monoclonal antibodies designed to block immune-checkpoint mechanisms have been developed and show efficacy in other cancers, such as melanoma. On the other hand, active immunotherapy approaches, such as vaccines, have shown encouraging outcomes. We believe that development of effective immunotherapy approaches should ultimately integrate those checkpoint-blockade agents to enhance the efficacy of therapeutic approaches. With these agents available, it is going to be quite an exciting time in the field. The eventual success of immunotherapies for brain tumors will be dependent upon not only an in-depth understanding of immunology behind the brain and brain tumors, but also collaboration and teamwork for the development of novel trials that address multiple layers of immunological challenges in gliomas.

  1. Attachment issues : kinetochore transformations and spindle checkpoint silencing

    NARCIS (Netherlands)

    Etemad, Banafsheh; Kops, Geert Jpl

    2016-01-01

    Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior to cellular fission. This process is guarded by the spindle assembly checkpoint (SAC), which prevents the anaphase of cell division until stable connections between spindle microtubules and the kinetoc

  2. Immune-Checkpoint Blockade and Active Immunotherapy for Glioma

    International Nuclear Information System (INIS)

    Cancer immunotherapy has made tremendous progress, including promising results in patients with malignant gliomas. Nonetheless, the immunological microenvironment of the brain and tumors arising therein is still believed to be suboptimal for sufficient antitumor immune responses for a variety of reasons, including the operation of “immune-checkpoint” mechanisms. While these mechanisms prevent autoimmunity in physiological conditions, malignant tumors, including brain tumors, actively employ these mechanisms to evade from immunological attacks. Development of agents designed to unblock these checkpoint steps is currently one of the most active areas of cancer research. In this review, we summarize recent progresses in the field of brain tumor immunology with particular foci in the area of immune-checkpoint mechanisms and development of active immunotherapy strategies. In the last decade, a number of specific monoclonal antibodies designed to block immune-checkpoint mechanisms have been developed and show efficacy in other cancers, such as melanoma. On the other hand, active immunotherapy approaches, such as vaccines, have shown encouraging outcomes. We believe that development of effective immunotherapy approaches should ultimately integrate those checkpoint-blockade agents to enhance the efficacy of therapeutic approaches. With these agents available, it is going to be quite an exciting time in the field. The eventual success of immunotherapies for brain tumors will be dependent upon not only an in-depth understanding of immunology behind the brain and brain tumors, but also collaboration and teamwork for the development of novel trials that address multiple layers of immunological challenges in gliomas

  3. Liberal nationalism on immigration

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2009-01-01

    Liberal nationalists such as David Miller and Will Kymlicka have claimed that liberal principles have implausible implications with regard to the issue of immigration. They hold that nationality should play a normative role in this regard, and that this is necessary in order to justify restrictions...... on immigration. The present chapter discusses the envisaged role for considerations of nationality with regard to admission and residence, and examines the actual implications of arguments advanced by liberal nationalists as to why nationality should play this role. It is argued that the connection...... between nationality and immigration on liberal nationalist premises is not as straightforward as one might expect, and that the addition of considerations of nationality to liberal principles makes no practical difference with regard to reasons for restricting immigration or criteria of selection among...

  4. Immigrant Child Poverty

    DEFF Research Database (Denmark)

    Galloway, Taryn Ann; Gustafsson, Björn; Pedersen, Peder J.;

    2015-01-01

    Immigrant and native child poverty in Denmark, Norway, and Sweden 1993–2001 is studied using large sets of panel data. While native children face yearly poverty risks of less than 10 percent in all three countries and for all years studied the increasing proportion of immigrant children...... with an origin in middle- and low-income countries have poverty risks that vary from 38 up to as much as 58 percent. At the end of the observation period, one third of the poor children in Norway and as high as about a half in Denmark and in Sweden are of immigrant origin. The strong overrepresentation...... of immigrant children from low- and middle-income countries when measured in yearly data is also found when applying a longer accounting period for poverty measurement. We find that child poverty rates are generally high shortly after arrival to the new country and typically decrease with years since...

  5. Experiences with treating immigrants

    DEFF Research Database (Denmark)

    Sandhu, Sima; Bjerre, Neele V; Dauvrin, Marie;

    2012-01-01

    human trafficking. Interviews were transcribed and analysed using thematic analysis. RESULTS: The interviews highlighted specific challenges to treating immigrants in mental health services across all 16 countries including complications with diagnosis, difficulty in developing trust and increased risk...

  6. Immigrants and Native Workers

    DEFF Research Database (Denmark)

    Foged, Mette; Peri, Giovanni

    Using a database that includes the universe of individuals and establishments in Denmark over the period 1991-2008 we analyze the effect of a large inflow of non-European (EU) immigrants on Danish workers. We first identify a sharp and sustained supply-driven increase in the inflow of non......-EU immigrants in Denmark, beginning in 1995 and driven by a sequence of international events such as the Bosnian, Somalian and Iraqi crises. We then look at the response of occupational complexity, job upgrading and downgrading, wage and employment of natives in the short and long run. We find that the...... increased supply of non-EU low skilled immigrants pushed native workers to pursue more complex occupations. This reallocation happened mainly through movement across firms. Immigration increased mobility of natives across firms and across municipalities but it did not increase their probability of...

  7. Libertarianism and Immigration

    Directory of Open Access Journals (Sweden)

    Diana Virginia Todea

    2010-11-01

    Full Text Available In this paper I investigate the libertarian account of immigration. In the first section I distinguish between right-libertarianism and left-libertarianism. In the second section I analyze the arguments focused on immigration from the perspective of self-ownership focused on Nozick’s case and Steiner’s analogy. In the third section I discuss the conflict between the collective consent on the issue of immigration and the individuals’ decision. The conclusion sets the libertarian framework as being flawed in its argumentation on the issue of immigration because it fails to provide strong arguments about the fact that the individuals are free to choose to open or close the borders.

  8. Checkpointing for graceful degradation in distributed embedded systems

    Science.gov (United States)

    Sababha, Belal Hussein

    Graceful degradation is an approach to developing dependable safety-critical embedded applications, where redundant active or standby resources are used to cope with faults through a system reconfiguration at run-time. Compared to traditional hardware and software redundancy, it is a promising technique that may achieve dependability with a significant reduction in cost, size, weight, and power requirements. Reconfiguration at run-time necessitates using proper checkpointing protocols to support state reservation to ensure correct task restarts after a system reconfiguration. One of the most common checkpointing protocols are communication induced checkpointing (CIC) protocols, which are well developed and understood for large parallel and information systems, but not much has been done for resource limited embedded systems. This work implements and evaluates some of the most common CIC protocols in a periodic resource constrained distributed embedded system for graceful degradation purposes. A test-bed has been developed and used for the evaluation of the various protocols. The implemented protocols are thoroughly studied and performances are contrasted. Specifically the periodicity property and how it benefits checkpointing in embedded systems is investigated. This work introduces a unique effort of CIC protocol implementation and evaluation in the field of distributed embedded systems. Other than providing a test-bed for graceful degradation support, this work shows that some checkpointing protocols that are not efficient in large information systems and supercomputers perform well in embedded systems. We show that a simple index-based CIC protocol, such as the BCS protocol, is more appropriate in embedded system applications compared to other protocols that piggyback a significant amount of information to reduce the number of forced checkpoints. Finally, this work proposes a whole graceful degradation approach to achieve fault tolerance in resource constrained

  9. Local regulation of immigration

    OpenAIRE

    Appleby, Clare A.

    2009-01-01

    Cities and states across the United States are attempting to formulate immigration policies. What is driving these local ordinances, and what are the consequences of such attempts? To answer these questions, this thesis examines Farmers Branch, Texas and Arizona. Both communities have experienced significant growth in their foreign born population over the last two decades. Mexican immigrants account for the majority of the growth in both locations. This growth and the pervasive stereotype of...

  10. Diabetes Screening Among Immigrants

    OpenAIRE

    Creatore, Maria I.; Gillian L Booth; Manuel, Douglas G.; Moineddin, Rahim; Glazier, Richard H.

    2012-01-01

    OBJECTIVE To examine diabetes screening, predictors of screening, and the burden of undiagnosed diabetes in the immigrant population and whether these estimates differ by ethnicity. RESEARCH DESIGN AND METHODS A population-based retrospective cohort linking administrative health data to immigration files was used to follow the entire diabetes-free population aged 40 years and up in Ontario, Canada (N = 3,484,222) for 3 years (2004–2007) to determine whether individuals were screened for diabe...

  11. How integrated are immigrants?

    OpenAIRE

    Rickard Sandell; Pierluigi Contucci

    2015-01-01

    Background: The successful integration of immigrants is seen as a principal means to secure economic growth and welfare in many countries. Success in this task depends on the capacity to formulate effective integration policies, which in turn is based on research capable of describing and explaining the integration process properly. Objective: Our objective is to define a conceptual and quantifiable measure of full immigrant integration.This enables a quantitative evaluation of how integra...

  12. Democratic Europe and immigrants

    Directory of Open Access Journals (Sweden)

    Lidak J.

    2012-06-01

    Full Text Available Author dicusses the problems of today’s democracies that are connected to increasing international migration. He mentions especially the rise of extreme-right political parties, changes in the attitudes to immigrants, as well as the problems caused illegal immigration. Europe will have to get used to increased Muslim presence on the continent and accept it, though it poses a certain threat to democracy as we know it.

  13. Immigrant Teachers in Australia

    OpenAIRE

    Jock Collins; Carol Reid

    2012-01-01

    One of the features of contemporary society is the increasing global mobility of professionals. While the education industry is a key site of the demand for contemporary global professional migration, little attention has been given to the global circulation of education professionals. Over past decades, immigrant teachers have been an important component of skilled and professional immigration into Australia, there is no comprehensive contemporary national study of the experiences of immigra...

  14. Cell size checkpoint control by the retinoblastoma tumor suppressor pathway.

    Directory of Open Access Journals (Sweden)

    Su-Chiung Fang

    2006-10-01

    Full Text Available Size control is essential for all proliferating cells, and is thought to be regulated by checkpoints that couple cell size to cell cycle progression. The aberrant cell-size phenotypes caused by mutations in the retinoblastoma (RB tumor suppressor pathway are consistent with a role in size checkpoint control, but indirect effects on size caused by altered cell cycle kinetics are difficult to rule out. The multiple fission cell cycle of the unicellular alga Chlamydomonas reinhardtii uncouples growth from division, allowing direct assessment of the relationship between size phenotypes and checkpoint function. Mutations in the C. reinhardtii RB homolog encoded by MAT3 cause supernumerous cell divisions and small cells, suggesting a role for MAT3 in size control. We identified suppressors of an mat3 null allele that had recessive mutations in DP1 or dominant mutations in E2F1, loci encoding homologs of a heterodimeric transcription factor that is targeted by RB-related proteins. Significantly, we determined that the dp1 and e2f1 phenotypes were caused by defects in size checkpoint control and were not due to a lengthened cell cycle. Despite their cell division defects, mat3, dp1, and e2f1 mutants showed almost no changes in periodic transcription of genes induced during S phase and mitosis, many of which are conserved targets of the RB pathway. Conversely, we found that regulation of cell size was unaffected when S phase and mitotic transcription were inhibited. Our data provide direct evidence that the RB pathway mediates cell size checkpoint control and suggest that such control is not directly coupled to the magnitude of periodic cell cycle transcription.

  15. IMMIGRATION, IDENTITY AND LITERATURE

    Directory of Open Access Journals (Sweden)

    Semran CENGİZ

    2010-12-01

    Full Text Available The leading problems incidental to the globalization are the immigration, the poverty, the adaptation problems of the immigrants, the identity and the cultural conflicts. The globalization actors that are transforming the whole world to a huge market, consider to commercialize the product even to the people at the other end of the world. Therefore they lay emphasis on its local identity and remark its variety as its richness. In this way the limits are easily exceeded and the consumption culture becomes available to be instilled upon even the people at the back of the beyond. However one party always wins; the more some people consume, the more some people make profit. The people who does not have any power to consume anymore, becomes the guest of the ones who get them adopt this habit and desires to receive a share from this profit.The modern world people who are not pleased with this situation, have made every effort to alienate the immigrants from the center but they could not succeed. The situation that gave rise to a conflict between parties, have also led the identity problems to occur. In the present situation, the immigrants are trying to take place in the modern world as people with hybrid identities. The music produced by the children of the immigrants with double identities, attracts attention of the world where the immigrant identity, changing its shell, promises hope as the conciliation area of the new century.

  16. Labor Market Discrimination: Vietnamese Immigrants

    Directory of Open Access Journals (Sweden)

    Linus Yamane

    2012-01-01

    Full Text Available Vietnamese and East European immigrants face similar obstacles in the US labor market. This provides for an interesting test of racial discrimination in the labor market. Does it make any difference if an immigrant is Asian or White? When Vietnamese immigrants are compared to East European immigrants, Vietnamese men earn 7-9% less than comparable East European men, with more discrimination among the less educated, and in the larger Vietnamese population centers like California. Vietnamese women earn as much as comparable East European women. Vietnamese immigrants, male and female, are much less likely to hold managerial and supervisory positions than comparable East European immigrants.

  17. Labor Market Discrimination: Vietnamese Immigrants

    Directory of Open Access Journals (Sweden)

    Linus Yamane

    2012-01-01

    Full Text Available Vietnamese and East European immigrants face similar obstacles in the U.S. labor market. This provides for an interesting test of racial discrimination in the labor market. Does it make any difference if an immigrant is Asian or White? When Vietnamese immigrants are compared to East European immigrants, Vietnamese men earn 7-9% less than comparable East European men, with more discrimination among the less educated, and in the larger Vietnamese population centers like California. Vietnamese women earn as much as comparable East European women. Vietnamese immigrants, male and female, are much less likely to hold managerial and supervisory positions than comparable East European immigrants.

  18. Language Skills and Immigrant Adjustment : What Immigration Policy Can Do!

    OpenAIRE

    Chiswick, Barry R; Paul W. Miller

    2004-01-01

    This study provides an account of the dynamics of the dominant language adjustment process among immigrants in Australia using the Longitudinal Survey of Immigrants to Australia, which comprises two cohorts of immigrants that arrived in Australia around five years apart. There are two special features of these data that provide the framework for analysis. First, the visa class under which the immigrants entered Australia is known from administrative records. Second, between the two surveys, s...

  19. The Economic Benefits from Immigration

    OpenAIRE

    George J. Borjas

    1995-01-01

    Natives benefit from immigration mainly because of production complementarities between immigrant workers and other factors of production, and these benefits are larger when immigrants are sufficiently `different' from the stock of native productive inputs. The available evidence suggests that the economic benefits from immigration for the United States are small, on the order of $6 billion and almost certainly less than $20 billion annually. These gains, however, could be increased considera...

  20. Immigrant Mental Health and Unemployment

    OpenAIRE

    Steven Kennedy

    2003-01-01

    The objective of this research is to assess whether stress associated with the transition to a new country combined with additional stress arising from unemployment affects the mental health of immigrants. I use the Longitudinal Survey of Immigrants to Australia (LSIA) to examine the effect of labour force status on the mental health of immigrants. By using a rich longitudinal data set, I am able to control for individual immigrant differences whilst examining whether changes in mental health...

  1. Editorial: Immigrant and Ethnic Entrepreneurship

    OpenAIRE

    Jan Brzozowski

    2016-01-01

    The importance of businesses started and developed by immigrants is host countries is substantial. Just in the US, 90 of the enterprises listed on Fortune 500 have been founded by immigrants, and additional 114 have been started by the second-generation immigrants, i.e. children of foreign-born persons (cf. Partnership for a New American Economy, 2011). As the contribution of immigrant entrepreneurship for the global economy is recognized by policy makers and experts, it is also reflected in ...

  2. Immigrant earnings: a longitudinal analysis

    OpenAIRE

    Chiswick, Barry R; Lee, Yew Liang; Paul W. Miller

    2005-01-01

    This paper uses the Longitudinal Survey of Immigrants to Australia to analyze the determinants of the level and growth in earnings of adult male immigrants in their first 3.5 years in Australia. The theoretical framework is based on the immigrant adjustment model, which incorporates both the transferability of immigrant skills and selectively in migration. The cross-sectional and longitudinal analyses generate similar findings. The level and relative growth of earnings are higher for immigran...

  3. Interpersonal relationships of immigrant students

    OpenAIRE

    Olkinuora-Guzman, Johanna

    2011-01-01

    This study explores the interpersonal relationships of immigrant students. This is a current topic because immigration to Finland has increased rapidly and student groups are more diverse than ever before. The aim is to study immigrant students’ experiences and expectations of their interpersonal relationships and how they develop and maintain them, and also to understand how interpersonal relationships affect the immigrant students’ adaptation to the new environment. This study is qualitativ...

  4. Immigration and Swiss House Prices

    OpenAIRE

    Degen, Kathrin; Andreas M. Fischer

    2010-01-01

    This study examines the behavior of Swiss house prices to immigration flows for 85 districts from 2001 to 2006. The results show that the nexus between immigration and house prices holds even in an environment of low house price inflation, nationwide rent control, and modest immigration flows. An immigration inflow equal to 1% of an area's population is coincident with an increase in prices for single-family homes of about 2.7%: a result consistent with previous studies. The overall immigrati...

  5. Review of some Minimum-Process Synchronous Checkpointing Schemes for Mobile Distributed Systems

    Directory of Open Access Journals (Sweden)

    Preeti Gupta,

    2010-07-01

    Full Text Available The term Distributed Systems is used to describe a system with the following characteristics: i it consists of several computers that do not share memory or a clock, ii the computers communicate with each other by exchanging messages over a communication network, iii each computer has its own memory and runs its own operating system. A mobile computing system is a distributed system where some of processes are running on mobile hosts (MHs, whose location in the network changes with time. The number of processes that take checkpoints is minimized to 1 avoid awakening of MHs in doze mode of operation, 2 minimize thrashing of MHs with checkpointing activity, 3 save limited battery life of MHs and low bandwidth of wireless channels. In minimum-process checkpointing protocols, some useless checkpoints are taken or blocking of processes takes place. To take a checkpoint, an MH has to transfer a large amount of checkpoint data to its local MSS over the wireless network. Since the wireless network has low bandwidth and MHs have low computation power, all-process checkpointing will waste the scarce resources of the mobile system on every checkpoint.Minimum-process coordinated checkpointing is a preferred approach for mobile distributed systems. In this paper, we discuss various existing minimum-process checkpointing protocols for mobile distributed systems.

  6. Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions.

    Science.gov (United States)

    Ólafsson, Guðjón; Thorpe, Peter H

    2016-01-01

    The spindle assembly checkpoint (SAC) is a key mechanism to regulate the timing of mitosis and ensure that chromosomes are correctly segregated to daughter cells. The recruitment of the Mad1 and Mad2 proteins to the kinetochore is normally necessary for SAC activation. This recruitment is coordinated by the SAC kinase Mps1, which phosphorylates residues at the kinetochore to facilitate binding of Bub1, Bub3, Mad1, and Mad2. There is evidence that the essential function of Mps1 is to direct recruitment of Mad1/2. To test this model, we have systematically recruited Mad1, Mad2, and Mps1 to most proteins in the yeast kinetochore, and find that, while Mps1 is sufficient for checkpoint activation, recruitment of either Mad1 or Mad2 is not. These data indicate an important role for Mps1 phosphorylation in SAC activation, beyond the direct recruitment of Mad1 and Mad2. PMID:27280788

  7. Epigenetic modifiers in immunotherapy: a focus on checkpoint inhibitors.

    Science.gov (United States)

    Terranova-Barberio, Manuela; Thomas, Scott; Munster, Pamela N

    2016-06-01

    Immune surveillance should be directed to suppress tumor development and progression, involving a balance of coinhibitory and costimulatory signals that amplify immune response without overwhelming the host. Immunotherapy confers durable clinical benefit in 'immunogenic tumors', whereas in other tumors the responses are modest. Thus, immune checkpoint inhibitors may need to be combined with strategies to boost immune response or increase the tumor immune profile. Epigenetic aberrations contribute significantly to carcinogenesis. Recent findings suggest that epigenetic drugs prime the immune response by increasing expression of tumor-associated antigens and immune-related genes, as well as modulating chemokines and cytokines involved in immune system activation. This review describes our current understanding regarding epigenetic and immunotherapy combination, focusing on immune response priming to checkpoint blockade. PMID:27197539

  8. [Tuberculosis and immigration].

    Science.gov (United States)

    Salas-Coronas, Joaquín; Rogado-González, M Cruz; Lozano-Serrano, Ana Belén; Cabezas-Fernández, M Teresa

    2016-04-01

    The incidence of tuberculosis worldwide is declining. However, in Western countries this decline is slower due to the impact of immigration. Tuberculosis in the immigrant population is related to health status in the country of origin and with overcrowding and poverty conditions in the host country. Immigrants with tuberculosis are younger, have a higher prevalence of extrapulmonary forms, greater proportion of drug resistance and higher treatment default rates than those of natives. New molecular techniques not only reduce diagnostic delay time but also allow the rapid identification of resistances and improve knowledge of transmission patterns. It is necessary to implement measures to improve treatment compliance in this population group like facilitating access to health card, the use of fixed-dose combination drugs, the participation of cultural mediators and community health workers and gratuity of drugs. PMID:26851978

  9. Checkpoint signaling from a single DNA interstrand crosslink

    OpenAIRE

    Ben-Yehoyada, Merav; Wang, Lily C; Kozekov, Ivan D.; Rizzo, Carmelo J.; Gottesman, Max E.; Gautier, Jean

    2009-01-01

    DNA interstrand crosslinks (ICLs) are the most toxic lesions induced by chemotherapeutic agents such as Mitomycin C and Cisplatin. By covalently linking both DNA strands, ICLs prevent DNA melting, transcription, and replication. Studies on ICL signaling and repair have been limited because these drugs generate additional DNA lesions that trigger checkpoint signaling. Here, we monitor sensing, signaling from and repairing of a single, site-specific ICL in cell-free extract derived from Xenopus...

  10. Checkpointing for the RESTART problem in Markov networks

    OpenAIRE

    Lipsky, Lester; Doran, Derek; Gokhale, Swapna

    2011-01-01

    We apply the known formulae of the RESTART problem to Markov models of software (and many other) systems, and derive new equations. We show how checkpoints might be included, with their resultant performance under RESTART. The result is a complete procedure for finding the mean, variance, and tail behavior of the job completion time as a function of the failure rate. We also provide a detailed example.

  11. Immigration reform, American style.

    Science.gov (United States)

    Papademetriou, D G

    1984-01-01

    This article reviews the background of the proposed Immigration and Reform Act (also known as the Simpson-Mazzoli bill), which seeks to overhaul US immigration law for the first time since 1952. This bill is consistent with President Reagan's hard line on border enforcement and mandates stiff penalties for those who transport illegal aliens for commercial advantage or private profit. It further offers Mexico preferential treatment in immigration (40,000 additional visas/year). It includes an amnesty program to offer legal status to qualified illegal residents. The bill directs the President to develop a secure national worker identification system and would create a large-scale temporary foreign agricultural program for perishable commodities. Agricultural workers' families would not be eligible to accompany them unless they also obtain temporary visas. Foreign temporary workers, employable only in cases where local domestic workers are not available, must be provided with wages and working conditions equal to those prevailing among domestic workers. Stiff penalties are stipulated for employers who fail to abide with the terms of the program. In the author's opinion, this bill fails to appreciate the global character of international migration and its complexity. It relects a fundamental ambivalence about a strictly controlled main gate versus a back door approach to immigration as well as the conflicting images of the US as a nation of immigrants versus the historical reality of American nativism and xenophobia. Needed are comprehensive initiatives whose mutually reinforcing components can address the multiple dimensions of the immigration problem within a framework that does not ignore workers who have contributed to the economic well-being of the US, regardless of their legal status. PMID:12159575

  12. A Monitor for Bud Emergence in the Yeast Morphogenesis Checkpoint

    Science.gov (United States)

    Theesfeld, Chandra L.; Zyla, Trevin R.; Bardes, Elaine G.S.; Lew, Daniel J.

    2003-01-01

    Cell cycle transitions are subject to regulation by both external signals and internal checkpoints that monitor satisfactory progression of key cell cycle events. In budding yeast, the morphogenesis checkpoint arrests the cell cycle in response to perturbations that affect the actin cytoskeleton and bud formation. Herein, we identify a step in this checkpoint pathway that seems to be directly responsive to bud emergence. Activation of the kinase Hsl1p is dependent upon its recruitment to a cortical domain organized by the septins, a family of conserved filament-forming proteins. Under conditions that delayed or blocked bud emergence, Hsl1p recruitment to the septin cortex still took place, but hyperphosphorylation of Hsl1p and recruitment of the Hsl1p-binding protein Hsl7p to the septin cortex only occurred after bud emergence. At this time, the septin cortex spread to form a collar between mother and bud, and Hsl1p and Hsl7p were restricted to the bud side of the septin collar. We discuss models for translating cellular geometry (in this case, the emergence of a bud) into biochemical signals regulating cell proliferation. PMID:12925763

  13. Potential biomarker for checkpoint blockade immunotherapy and treatment strategy.

    Science.gov (United States)

    Dong, Zhong-Yi; Wu, Si-Pei; Liao, Ri-Qiang; Huang, Shu-Mei; Wu, Yi-Long

    2016-04-01

    Programmed cell death protein-1 (PD-1) and ligand (PD-L1) provide an important escape mechanism from immune attack, and blockade therapy of these proteins show promising clinical benefits in many types of cancer. PD-L1 can be induced by interferon-gamma (IFN-γ), hypoxia, or toll-like receptor (TLR)-mediated pathways that confer adaptive immune resistance, or upregulated by oncogenic signals leading to constitutive expression and resulting in intrinsic immune resistance. The PD-1/PD-L1 checkpoint blockade, which targets regulatory pathways in T cells to overcome immune resistance, is correlated to PD-L1 expression pattern and the presence of tumor-infiltrating lymphocytes (TILs). Meanwhile, immunogenic mutation loads show significant response to checkpoint blockade, which is probably due to PD-1/L1 status and TIL content. Finally, the clinical strategies to design effective checkpoint-targeting immunotherapies are based on the classification of inducible/constitutive expression of PD-L1 and the presence of TILs. PMID:26779629

  14. Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint

    Directory of Open Access Journals (Sweden)

    Ikram Mossaid

    2015-11-01

    Full Text Available The segregation of the chromosomes during mitosis is an important process, in which the replicated DNA content is properly allocated into two daughter cells. To ensure their genomic integrity, cells present an essential surveillance mechanism known as the spindle assembly checkpoint (SAC, which monitors the bipolar attachment of the mitotic spindle to chromosomes to prevent errors that would result in chromosome mis-segregation and aneuploidy. Multiple components of the nuclear pore complex (NPC, a gigantic protein complex that forms a channel through the nuclear envelope to allow nucleocytoplasmic exchange of macromolecules, were shown to be critical for faithful cell division and implicated in the regulation of different steps of the mitotic process, including kinetochore and spindle assembly as well as the SAC. In this review, we will describe current knowledge about the interconnection between the NPC and the SAC in an evolutional perspective, which primarily relies on the two mitotic checkpoint regulators, Mad1 and Mad2. We will further discuss the role of NPC constituents, the nucleoporins, in kinetochore and spindle assembly and the formation of the mitotic checkpoint complex during mitosis and interphase.

  15. Learning common lessons and checkpoints form human error incidents. Maintenance

    International Nuclear Information System (INIS)

    CRIEPI has been conducting detailed and structured analyses of all human error incidents collected from Japanese Licensee Event Reports using J-HPES (Japanese version of HPES) as an analysis method. Results obtained by the analyses have been stored in J-HPES database. This paper described the process to analyze J-HPES data concerning maintenance systematically to extract problems identified in the process of error action and checkpoints for preventing errors. Human error actions of these J-HPES data are classified by viewpoints of error mode and work type. As to each of these error categories, problems are extracted based on J-HPES causal relation charts in following three viewpoints: acts at workplace, activities, and preconditions of job. Moreover, checkpoints for preventing errors are developed referring proposed countermeasures in J-HPES database. In order to share these results, we started to issue 4-pages booklets 'Catch the Point' periodically. In future, based on these results, we will publish a teaching material. We also have a plan to store the contents of Catch the Point in a database, which facilitate users to find necessary checkpoints and hazards before they start their activities. (author)

  16. The New Immigration

    OpenAIRE

    Rumbaut, RG

    1995-01-01

    Immigration, it has been said, is the sincerest form of flattery. That may well be, but you wouldn't know it from the current political climate. It's open season on immigrants, from Europe to the United States. In Europe, migration and the control of external borders has become an issue of high politics, rising to the top of the policy agenda, even as the European Community (EC) was focusing on abolishing internal borders. In the U.S., it too has been a red-hot topic of public debate in state...

  17. Familles et immigration

    OpenAIRE

    Streiff-Fénart, Jocelyne

    2004-01-01

    A l'ère de la mondialisation, le devenir encore incertain et variable selon les groupes de l'immigration familiale se noue dans les rapports complexes entre des redéfinitions identitaires qui se jouent sur la scène culturelle mondialisée, et l'intégration des descendants des immigrés dans l'ordre national, qui se joue sur le terrain socio-économique et politique de l'égalisation des chances.

  18. Do immigrants cause crime?

    OpenAIRE

    Milo Bianchi; Paolo Buonanno; Paolo Pinotti

    2008-01-01

    Dans cet article nous examinons le rapport empirique entre immigration et crime dans les provinces italiennes pendant la période 1990-2003. Travaillant à partie de données administratives de la police, nous constatons d'abord que la taille de la population immigrée est positivement correlée avec la fréquence des atteintes à la propriété et avec le taux de criminalité dans son ensemble. Puis, nous employons des variables instrumentales basées sur la migration vers d'autres pays européens pour ...

  19. Immigrants' location preferences

    DEFF Research Database (Denmark)

    Damm, Anna Piil

    This paper exploits a spatial dispersal policy for refugee immigrants to estimate the importance of local and regional factors for refugees' location preferences. The main results of a mixed proportional hazard competing risks model are that placed refugees react to high regional unemployment and...... lack of a local immigrant population by migrating to large municipalities. Lack of local fellow countrymen, however, increases the exit rate to medium-sized as well as large municipalities. This finding is likely to be a result of the dispersal policy. Finally, refugees react strongly to assignment to...

  20. Emodnet Med Sea Check-Point - Indicators for decision- maker

    Science.gov (United States)

    Besnard, Sophie; Claverie, Vincent; Blanc, Frédérique

    2015-04-01

    The Emodnet Checkpoint projects aim is to assess the cost-effectiveness, reliability and utility of the existing monitoring at the sea basin level. This involves the development of monitoring system indicators and a GIS Platform to perform the assessment and make it available. Assessment or production of Check-Point information is made by developing targeted products based on the monitoring data and determining whether the products are meeting the needs of industry and public authorities. Check-point users are the research community, the 'institutional' policy makers for IMP and MSFD implementation, the 'intermediate users', i.e., users capable to understand basic raw data but that benefit from seeing the Checkpoint targeted products and the assessment of the fitness for purpose. We define assessment criteria aimed to characterize/depict the input datasets in terms of 3 territories capable to show performance and gaps of the present monitoring system, appropriateness, availability and fitness for purpose. • Appropriateness: What is made available to users? What motivate/decide them to select this observation rather than this one. • Availability: How this is made available to the user? Place to understand the readiness and service performance of the EU infrastructure • Fitness for use / fitness for purpose: Ability for non-expert user to appreciate the data exploitability (feedback on efficiency & reliability of marine data) For each territory (appropriateness, Availability and Fitness for purpose / for use), we define several indicators. For example, for Availability we define Visibility, Accessibility and Performance. And Visibility is itself defined by "Easily found" and "EU service". So these indicators can be classified according to their territory and sub-territory as seen above, but also according to the complexity to build them. Indicators are built from raw descriptors in 3 stages:  Stage 1: to give a neutral and basic status directly computed from

  1. Immigrant Capital and Entrepreneurial Opportunities

    Directory of Open Access Journals (Sweden)

    Malavika Sundararajan

    2016-01-01

    Full Text Available Objective: The main objective of this study is to define and operationalize the concept of immigrant capital, a key factor that differentiates immigrant from host country entrepreneurs in how they recognize and start new ventures. Research Design & Methods: A detailed analysis of contemporary immigrant entrepreneurship and opportunity recognition literature was carried out. Using grounded theory, we synthesized the outcomes from the analysis of eight Canadian and U.S. case studies of successful immigrant entrepreneurs with the key findings from the literature to define and develop a model of immigrant capital. Findings: Based on our grounded theory development process we show that the concept of immigrant capital as a distillate of human, cultural, economic and social capital that goes beyond expected opportunity recognition (OR drivers like prior knowledge and prior experience to differentiate and enhance the immigrant entrepreneur’s ability to recognize business opportunities compared to host country entrepreneurs. We found immigrant capital to be a consequence of being boundary spanners in host and home country networks. Implications & Recommendations: Understanding a unique resource like immigrant capital, will help immigrant as well as host country entrepreneurs further develop their opportunity recognition ability by bridging gaps and fulfilling the needs for both, immigrant and host country consumers. Contribution & Value Added: The main contribution is the theoretical development, identification and definition of the immigrant capital model and propositions that will articulate the factors that lead to the conceptualization and operationalization of immigrant capital. Furthermore, the immigrant capital model can serve host country entrepreneurs to develop cross-cultural networks and jump-start entrepreneurial activities in their home countries as well as learn how to expand their operations into global markets.

  2. Checkpoint Defects Leading to Premature Mitosis Also Cause Endoreplication of DNA in Aspergillus nidulans

    OpenAIRE

    De Souza, Colin P. C.; Ye, Xiang S.; Osmani, Stephen A.

    1999-01-01

    The G2 DNA damage and slowing of S-phase checkpoints over mitosis function through tyrosine phosphorylation of NIMXcdc2 in Aspergillus nidulans. We demonstrate that breaking these checkpoints leads to a defective premature mitosis followed by dramatic rereplication of genomic DNA. Two additional checkpoint functions, uvsB and uvsD, also cause the rereplication phenotype after their mutation allows premature mitosis in the presence of low concentrations of hydroxyurea. uvsB is shown to encode ...

  3. The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts.

    OpenAIRE

    Adjerid, Nassiba

    2008-01-01

    When unreplicated or damaged DNA is present, cell cycle checkpoint pathways cause cell cycle arrest by inhibiting cyclin-dependent kinases (Cdks). In Xenopus laevis, early embryonic development consists of twelve rapid cleavage cycles between DNA replication (S) and mitosis (M) without checkpoints or gap phases. However, checkpoints are engaged in Xenopus once the embryo reaches the midblastula transition (MBT). At this point, the embryo initiates transcription, acquires gap phases between S...

  4. Assays Used to Study the DNA Replication Checkpoint in Fission Yeast

    OpenAIRE

    Noguchi, Eishi; Ansbach, Alison B.; Noguchi, Chiaki; Russell, Paul

    2009-01-01

    The DNA replication checkpoint, also known as the intra-S or S-phase checkpoint, plays a central role in ensuring the accuracy of DNA replication. When replication is impeded by DNA damage or other conditions, this checkpoint delays cell cycle progression and coordinates resumption of replication with DNA repair pathways. One of its critical functions is to stabilize stalled replication forks in a replication-competent state, presumably by maintaining proper assembly of replisome components a...

  5. Academic Mobility and Immigration

    Science.gov (United States)

    Tremblay, Karine

    2005-01-01

    In the late 1990s, sustained economic growth in most Organisation for Economic Cooperation and Development (OECD) countries and the development of the information economy led to a considerable increase in migration of highly skilled individuals, especially in science and technology. Some OECD countries relaxed their immigration policies to attract…

  6. Wealth & Immigration in Denmark

    DEFF Research Database (Denmark)

    Dreyer, Johannes Kabderian; Wolffsen, Poul; Mortensen, Mia

    2014-01-01

    Applying newly developed methods this paper quantifies human capital in Denmark and analyzes highly qualified immigration as a potential source of wealth generation. In order to quantify human capital, we use the methodology of Lettau and Ludvigson (2001, 2004), Zhang (2006) and Dreyer et al. (2013...

  7. Can immigrants hurt trade?

    Czech Academy of Sciences Publication Activity Database

    Konečný, Tomáš

    -, č. 329 (2007), s. 1-42. ISSN 1211-3298 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : immigrants * international trade * informal trade barriers Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp329.pdf

  8. Action-oriented use of ergonomic checkpoints for healthy work design in different settings.

    Science.gov (United States)

    Kogi, Kazutaka

    2007-12-01

    Recent experiences in the action-oriented use of ergonomic checkpoints in different work settings are reviewed. The purpose is to know what features are useful for healthy work design adjusted to each local situation. Based on the review results, common features of ergonomic checkpoints used in participatory training programs for improving workplace conditions in small enterprises, construction sites, home work and agriculture in industrially developing countries in Asia are discussed. These checkpoints generally compile practical improvement options in a broad range of technical areas, such as materials handling, workstation design, physical environment and work organization. Usually, "action checklists" comprising the tiles of the checkpoints are used together. A clear focus is placed on readily applicable low-cost options. Three common features of these various checkpoints appear to be important. First, the checkpoints represent typical good practices in multiple areas. Second, each how-to section of these checkpoints presents simple improvements reflecting basic ergonomic principles. Examples of these principles include easy reach, fewer and faster transport, elbow-level work, coded displays, isolated or screened hazards and shared teamwork. Third, the illustrated checkpoints accompanied by corresponding checklists are used as group work tools in short-term training courses. Many practical improvements achieved are displayed in websites for inter-country work improvement networks. It is suggested to promote the use of locally adjusted checkpoints in various forms of participatory action-oriented training in small-scale workplaces and in agriculture particularly in industrially developing countries. PMID:18572793

  9. Task Specialization, Immigration, and Wages

    OpenAIRE

    Peri, Giovanni; Sparber, Chad

    2008-01-01

    Many workers with low levels of educational attainment immigrated to the United States in recent decades. Large inflows of less-educated immigrants would reduce wages paid to comparably-educated native-born workers if the two groups are perfectly substitutable in production. In a simple model exploiting comparative advantage, however, we show that if less-educated foreign and native-born workers specialize in performing different tasks, immigration will cause natives to reallocate their...

  10. Ethnic goods and immigrant assimilation

    OpenAIRE

    Abdulloev, Ilhom; Epstein, Gil S.; Ira N. Gang

    2014-01-01

    Some immigrants try to keep their ethnicity hidden while others become ever deeply more mired in their home culture. We argue that among immigrants this struggle manifests itself in the ethnic goods they choose to consume. Different types of ethnic goods have vastly different effects on immigrant assimilation. We develop a simple theoretical model useful for capturing the consequences of this struggle, illustrating it with examples of Central Asian assimilation into the Muscovite economy.

  11. Immigration, Integration and Ghetto Formation

    Science.gov (United States)

    Meyer-Ortmanns, Hildegard

    We study ghetto formation in a population with natives and immigrants in the framework of the two-dimensional Ising-model with Kawasaki-exchange dynamics. It is the phase structure of the Ising model, the integration speed and the immigration rate which determine whether ghetto formation between natives and immigrants can be avoided or not. Our simulations are performed in- and out-of-equilibrium.

  12. Immigration, integration and ghetto formation

    OpenAIRE

    Meyer-Ortmanns, Hildegard

    2002-01-01

    We study ghetto formation in a population with natives and immigrants in the framework of the two-dimensional Ising-model with Kawasaki-exchange dynamics. It is the phase structure of the Ising model, the integration speed and the immigration rate which determine whether ghetto formation between natives and immigrants can be avoided or not. Our simulations are performed in and out-of equilibrium.

  13. Shifting landscapes of immigrant entrepreneurship

    OpenAIRE

    Kloosterman, R.; Rath, J.

    2010-01-01

    Although immigrant entrepreneurship still comprises small businesses confined to lower segments of markets, today immigrant entrepreneurs are also visible in the high-value activities that characterise advanced urban economies. The potential of self-employment to open up avenues of upward social mobility has also increased over time. This qualitative shift from low-value to high-value added business has emphasised the potential significance of immigrant entrepreneurs for the national and, in ...

  14. Immigrant Capital and Entrepreneurial Opportunities

    OpenAIRE

    Malavika Sundararajan; Binod Sundararajan

    2016-01-01

    Objective: The main objective of this study is to define and operationalize the concept of immigrant capital, a key factor that differentiates immigrant from host country entrepreneurs in how they recognize and start new ventures. Research Design & Methods: A detailed analysis of contemporary immigrant entrepreneurship and opportunity recognition literature was carried out. Using grounded theory, we synthesized the outcomes from the analysis of eight Canadian and U.S. case studies of successf...

  15. Immigration Wage Impacts by Origin

    OpenAIRE

    Bernt Bratsberg; Oddbjørn Raaum; Marianne Røed; Pål Schøne

    2010-01-01

    We estimate the direct partial wage effect for native workers of an immigrant-induced increase in labor supply, using longitudinal records drawn from Norwegian registers and the national skill cell approach of Borjas (2003). Our results show overall negative wage impacts for both men and women. Focusing on differential wage impacts by immigrant origin, we find that immigrant inflows from the neighboring Nordic countries have more negative wage effects than inflows from developing countries. T...

  16. Welfare Dependency among Danish Immigrants.

    OpenAIRE

    Blume, Kræn; Verner, Mette

    2006-01-01

    In this paper, we investigate determinants of the welfare dependency among immigrants in an assimilation framework. The duration of stay is a major determinant of welfare dependency. Also, assimilation patterns vary substantially across immigrants from developed and less devel-oped countries, respectively. The late arriving immigrants are relatively more dependent on transfers, explaining part of the general increase in welfare dependency during the latest years. This is partly attributed to ...

  17. Is there too little immigration?

    OpenAIRE

    Bandyopadhyay, Subhayu; Wall, Howard J.

    2007-01-01

    This paper presents a model of legal migration from one source country to two host countries, both of which can control their levels of immigration. Because of complementarities between capital and labor, the return on capital is positively related to the level of immigration. Consequently, when capital is immobile, host nations' optimal levels of immigration are positively related to their capital endowments. Further, when capital is mobile between the two host nations, the common return on ...

  18. The Self-Employment Experience of Immigrants

    OpenAIRE

    George J. Borjas

    1986-01-01

    Self-employment is an important aspect of the immigrant experience in the labor market. Self-employment rates for immigrants exceed 15 percent for some national groups. This paper addresses three related questions on the self-employment experience of immigrants. First, how do self-employment rates of immigrants compare to those of native-born men? Second, is there an "assimilation" effect on the self-employment propensity of immigrants? Finally, are the more recent waves of immigrants facing ...

  19. Immigrants' Labor Supply and Exchange Rate Volatility

    OpenAIRE

    Arash Nekoei

    2013-01-01

    Are an immigrant's decisions affected in real time by her home country's economy? I examine this question by exploiting exchange rate variations as exogenous price shocks to immigrants' budget constraints. I find that in response to a 10 percent dollar appreciation, an immigrant decreases her earnings by 0.92 percent, mainly by reducing hours worked. The exchange rate effect is greater for recent immigrants, married immigrants with absent spouses, Mexicans close to the border, and immigrants ...

  20. Immigration policy and self-selecting migrants

    OpenAIRE

    Milo Bianchi

    2008-01-01

    I build a simple theory of self-selection into migration and immigration policy formation. I show that any immigration policy affects immigrants skill composition, and this effect may drive the policy outcome in the receiving country. For example, restricting immigration when it is low skilled may worsen immigrants' self-selection and thus the receiving country skill distribution. Hence, understanding the migration decision becomes crucial for analyzing the political economy of immigration. B...

  1. Immigration Policy and Self-Selecting Migrants.

    OpenAIRE

    BIANCHI, MILO

    2013-01-01

    I build a simple theory of self-selection into migration and immigration policy formation. I show that any immigration policy affects immigrants skill composition, and this effect may drive the policy outcome in the receiving country. For example, restricting immigration when it is low skilled may worsen immigrants' self-selection and thus the receiving country skill distribution. Hence, understanding the migration decision becomes crucial for analyzing the political economy of immigration. B...

  2. EU enlargement and immigration

    OpenAIRE

    Kraus, Margit; Schwager, Robert

    2000-01-01

    This paper assesses the consequences of EU enlargement for East West migration. In the theoretical part, we identify several factors in addition to the reduction of moving costs by which EU membership influences migration. Specifically, EU accession affects income gaps. Moreover, if EU membership is refused, fear of future restrictions on immigration will lead to increased current migration. Additionally, casual evidence from the 1980s EU South enlargement is examined. Since then no increases...

  3. Immigration and Innovation

    OpenAIRE

    David C Maré; Fabling, Richard; Stillman, Steven

    2011-01-01

    We combine firm-level innovation data with area-level Census data to examine the relationship between local workforce characteristics, especially the presence of immigrants and local skills, and the likelihood of innovation by firms. We examine a range of innovation outcomes, and test the relationship for selected subgroups of firms. We find a positive relationship between local workforce characteristics and average innovation outcomes in labour market areas, but this is accounted for by vari...

  4. Immigration Enforcement Actions - Annual Report

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  5. From Multiculturalism to Immigration Shock

    OpenAIRE

    Paul Lauter

    2009-01-01

    Immigration is a tense political topic in virtually every Western country, and in many others as well. In fact, immigration is an international issue: 3 percent of the world's population, 191,000,000 people, now live in countries other than those in which they were born. This paper discusses why immigration is so fraught, the relation of the crisis over immigration to the growing fracture of the Western world's economy, as well as to terrorism like September 11 and the train bombings...

  6. Depression and Korean American immigrants.

    Science.gov (United States)

    Park, So-Youn; Bernstein, Kunsook Song

    2008-02-01

    Koreans are a relatively new and fast-growing immigrant group in the United States. Research has shown that immigration experiences are associated with depression, whereas acculturation and social support are moderating factors. Korean culture is informed by Confucianism, which emphasizes family integrity, group conformity, and traditional gender roles, and has influenced how Korean immigrants conceptualize depression, express depressive symptoms, and demonstrate help-seeking behavior. An understanding of Korean patterns of manifesting and expressing depression will be helpful to provide culturally appropriate mental health services to Korean American immigrants. PMID:18207052

  7. Activation of repair and checkpoints by double-strand breaks of DNA. Activational cascade of protein phosphorylation

    International Nuclear Information System (INIS)

    Molecular mechanisms of double-strand breaks repair and checkpoints include phosphorylations of repair and checkpoint-proteins by protein kinases. Chemical modification of proteins has different consequences including activation, changing of affinity to proteins and localization

  8. [Immigration to Venezuela].

    Science.gov (United States)

    Picouet, M; Pellegrino, A; Papail, J

    1986-11-01

    Immigration to Venezuela is examined using census data with the focus on the period 1971-1981. A brief overview of trends since the beginning of the twentieth century is first presented. The analysis indicates that "immigration to Venezuela is clearly of a short-term nature. Flows follow job opportunities and adjust to the labour market and to the financial capacity of the exchange market. The large increase of migratory movements to Venezuela in the 1970's is characterized by a diversification of their places of origin and by a greater instability. To a large extent, the migrants are illegal, especially those coming from Colombia and the Caribbean islands. Because of the crisis of the early 1980's, which is now worsened by the down trend of both oil prices and the U.S. dollar, Venezuela has become less attractive to immigrants, particularly from neighbouring countries." The authors observe that migrants in Venezuela are not well integrated and may depart, disrupting the labor supply in certain technical and specialized occupations (SUMMARY IN ENG AND SPA) PMID:12341015

  9. Centrosome-associated regulators of the G2/M checkpoint as targets for cancer therapy

    Directory of Open Access Journals (Sweden)

    Broaddus Russell R

    2009-02-01

    Full Text Available Abstract In eukaryotic cells, control mechanisms have developed that restrain cell-cycle transitions in response to stress. These regulatory pathways are termed cell-cycle checkpoints. The G2/M checkpoint prevents cells from entering mitosis when DNA is damaged in order to afford these cells an opportunity to repair the damaged DNA before propagating genetic defects to the daughter cells. If the damage is irreparable, checkpoint signaling might activate pathways that lead to apoptosis. Since alteration of cell-cycle control is a hallmark of tumorigenesis, cell-cycle regulators represent potential targets for therapy. The centrosome has recently come into focus as a critical cellular organelle that integrates G2/M checkpoint control and repairs signals in response to DNA damage. A growing number of G2/M checkpoint regulators have been found in the centrosome, suggesting that centrosome has an important role in G2/M checkpoint function. In this review, we discuss centrosome-associated regulators of the G2/M checkpoint, the dysregulation of this checkpoint in cancer, and potential candidate targets for cancer therapy.

  10. Twitter as a Tool to Warn Others about Sobriety Checkpoints: A Pilot Observational Study

    Science.gov (United States)

    Seitz, Christopher M.; Orsini, Muhsin Michael; Fearnow-Kenney, Melodie; Hatzudis, Kiki; Wyrick, David L.

    2012-01-01

    Anecdotal evidence suggests that young people use the website Twitter as a tool to warn drivers about the locations of sobriety checkpoints. Researchers investigated this claim by independently analyzing the website's content regarding a sample of 10 sobriety checkpoints that were conducted in cities throughout the United States during the weekend…

  11. Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A

    NARCIS (Netherlands)

    Wolthuis, Rob; Clay-Farrace, Lori; van Zon, Wouter; Yekezare, Mona; Koop, Lars; Ogink, Janneke; Medema, Rene; Pines, Jonathon

    2008-01-01

    Successful mitosis requires the right protein be degraded at the right time. Central to this is the spindle checkpoint that prevents the destruction of securin and cyclin 131 when there are improperly attached chromosomes. The principal target of the checkpoint is Cdc20, which activates the anaphase

  12. Space Reclamation for Uncoordinated Checkpointing in Message-Passing Systems. Ph.D. Thesis

    Science.gov (United States)

    Wang, Yi-Min

    1993-01-01

    Checkpointing and rollback recovery are techniques that can provide efficient recovery from transient process failures. In a message-passing system, the rollback of a message sender may cause the rollback of the corresponding receiver, and the system needs to roll back to a consistent set of checkpoints called recovery line. If the processes are allowed to take uncoordinated checkpoints, the above rollback propagation may result in the domino effect which prevents recovery line progression. Traditionally, only obsolete checkpoints before the global recovery line can be discarded, and the necessary and sufficient condition for identifying all garbage checkpoints has remained an open problem. A necessary and sufficient condition for achieving optimal garbage collection is derived and it is proved that the number of useful checkpoints is bounded by N(N+1)/2, where N is the number of processes. The approach is based on the maximum-sized antichain model of consistent global checkpoints and the technique of recovery line transformation and decomposition. It is also shown that, for systems requiring message logging to record in-transit messages, the same approach can be used to achieve optimal message log reclamation. As a final topic, a unifying framework is described by considering checkpoint coordination and exploiting piecewise determinism as mechanisms for bounding rollback propagation, and the applicability of the optimal garbage collection algorithm to domino-free recovery protocols is demonstrated.

  13. Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control

    DEFF Research Database (Denmark)

    Klein, Ditte Kjærsgaard; Hoffmann, Saskia; Ahlskog, Johanna K;

    2015-01-01

    an important role in checkpoint control following ionizing radiation. Cyclin F-depleted cells initiate checkpoint signalling after ionizing radiation, but fail to maintain G2 phase arrest and progress into mitosis prematurely. Importantly, cyclin F suppresses the B-Myb-driven transcriptional programme...

  14. Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy

    OpenAIRE

    Lutz, Eric R.; Kinkead, Heather; Jaffee, Elizabeth M.; Zheng, Lei

    2014-01-01

    Single agent immunotherapy is effective against several cancers, but has failed against poorly immunogenic cancers, including pancreatic cancer. Evaluation of pancreatic tumors following treatment with an experimental vaccine (Lutz et al. Cancer Immunology Research 2014) suggests that vaccination primes the tumor microenvironment (TME) for checkpoint-inhibitor immunotherapy, and supports a new platform for evaluating checkpoint-inhibitors in poorly immunogenic cancers.

  15. Identification of inhibitors of checkpoint kinase 1 through template screening.

    Science.gov (United States)

    Matthews, Thomas P; Klair, Suki; Burns, Samantha; Boxall, Kathy; Cherry, Michael; Fisher, Martin; Westwood, Isaac M; Walton, Michael I; McHardy, Tatiana; Cheung, Kwai-Ming J; Van Montfort, Rob; Williams, David; Aherne, G Wynne; Garrett, Michelle D; Reader, John; Collins, Ian

    2009-08-13

    Checkpoint kinase 1 (CHK1) is an oncology target of significant current interest. Inhibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient cancer cells to genotoxic therapies. Using template screening, a fragment-based approach to small molecule hit generation, we have identified multiple CHK1 inhibitor scaffolds suitable for further optimization. The sequential combination of in silico low molecular weight template selection, a high concentration biochemical assay and hit validation through protein-ligand X-ray crystallography provided 13 template hits from an initial in silico screening library of ca. 15000 compounds. The use of appropriate counter-screening to rule out nonspecific aggregation by test compounds was essential for optimum performance of the high concentration bioassay. One low molecular weight, weakly active purine template hit was progressed by iterative structure-based design to give submicromolar pyrazolopyridines with good ligand efficiency and appropriate CHK1-mediated cellular activity in HT29 colon cancer cells. PMID:19572549

  16. Cenp-meta is required for sustained spindle checkpoint

    Directory of Open Access Journals (Sweden)

    Thomas Rubin

    2014-05-01

    Full Text Available Cenp-E is a kinesin-like motor protein required for efficient end-on attachment of kinetochores to the spindle microtubules. Cenp-E immunodepletion in Xenopus mitotic extracts results in the loss of mitotic arrest and massive chromosome missegregation, whereas its depletion in mammalian cells leads to chromosome segregation defects despite the presence of a functional spindle assembly checkpoint (SAC. Cenp-meta has previously been reported to be the Drosophila homolog of vertebrate Cenp-E. In this study, we show that cenp-metaΔ mutant neuroblasts arrest in mitosis when treated with colchicine. cenp-metaΔ mutant cells display a mitotic delay. Yet, despite the persistence of the two checkpoint proteins Mad2 and BubR1 on unattached kinetochores, these cells eventually enter anaphase and give rise to highly aneuploid daughter cells. Indeed, we find that cenp-metaΔ mutant cells display a slow but continuous degradation of cyclin B, which eventually triggers the mitotic exit observed. Thus, our data provide evidence for a role of Cenp-meta in sustaining the SAC response.

  17. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

    OpenAIRE

    Biggins, Sue; Murray, Andrew W.

    2001-01-01

    The spindle checkpoint prevents cell cycle progression in cells that have mitotic spindle defects. Although several spindle defects activate the spindle checkpoint, the exact nature of the primary signal is unknown. We have found that the budding yeast member of the Aurora protein kinase family, Ipl1p, is required to maintain a subset of spindle checkpoint arrests. Ipl1p is required to maintain the spindle checkpoint that is induced by overexpression of the protein kinase Mps1. Inactivating I...

  18. Detailed Modeling, Design, and Evaluation of a Scalable Multi-level Checkpointing System

    Energy Technology Data Exchange (ETDEWEB)

    Moody, A T; Bronevetsky, G; Mohror, K M; de Supinski, B R

    2010-04-09

    High-performance computing (HPC) systems are growing more powerful by utilizing more hardware components. As the system mean-time-before-failure correspondingly drops, applications must checkpoint more frequently to make progress. However, as the system memory sizes grow faster than the bandwidth to the parallel file system, the cost of checkpointing begins to dominate application run times. A potential solution to this problem is to use multi-level checkpointing, which employs multiple types of checkpoints with different costs and different levels of resiliency in a single run. The goal is to design light-weight checkpoints to handle the most common failure modes and rely on more expensive checkpoints for less common, but more severe failures. While this approach is theoretically promising, it has not been fully evaluated in a large-scale, production system context. To this end we have designed a system, called the Scalable Checkpoint/Restart (SCR) library, that writes checkpoints to storage on the compute nodes utilizing RAM, Flash, or disk, in addition to the parallel file system. We present the performance and reliability properties of SCR as well as a probabilistic Markov model that predicts its performance on current and future systems. We show that multi-level checkpointing improves efficiency on existing large-scale systems and that this benefit increases as the system size grows. In particular, we developed low-cost checkpoint schemes that are 100x-1000x faster than the parallel file system and effective against 85% of our system failures. This leads to a gain in machine efficiency of up to 35%, and it reduces the the load on the parallel file system by a factor of two on current and future systems.

  19. Immigrant Workers and Farm Performance

    DEFF Research Database (Denmark)

    Malchow-Møller, Nikolaj; Munch, Jakob R.; Seidelin, Claus Aastrup;

    2013-01-01

    Danish farms in 1980–2008 to analyze the micro-level relationship between these two developments. Farms employing immigrants tend to be both larger than and no less productive than other farms. Furthermore, an increased use of immigrants is associated with an improvement in job creation and revenue...

  20. Identity Transformation of Korean Immigrants.

    Science.gov (United States)

    Kim, Saekyung; Gaa, John; Swank, Paul; Liberman, Dov

    Immigration is one of the most significant changes which can occur in one's lifetime. Immigrants struggle with their foreign environment and renewed crises; they suffer from "uprootedness" and "missed embeddedness" and have difficulty integrating their identity roles. Erikson's psychosocial development theory and Marcia's expansion of it are…

  1. Immigration and Religion in Denmark

    DEFF Research Database (Denmark)

    Christoffersen, Lisbet

    2009-01-01

    An overview over legal framework for immigration into Denmark, special clauses on religion as a parameter for residence permit and asylum in churches......An overview over legal framework for immigration into Denmark, special clauses on religion as a parameter for residence permit and asylum in churches...

  2. Overeducation among immigrants in Sweden

    DEFF Research Database (Denmark)

    Andersson Joona, Pernilla; Datta Gupta, Nabanita; Wadensjo, Eskil

    2014-01-01

    The utilization and reward of the human capital of immigrants in the labor market of the host country has been studied extensively. Using Swedish register data from 2001–2008, we extend the immigrant educational mismatch literature by analyzing incidence, wage effects and state dependence in...

  3. From Multiculturalism to Immigration Shock

    Directory of Open Access Journals (Sweden)

    Paul Lauter

    2009-02-01

    Full Text Available

    Immigration is a tense political topic in virtually every Western country, and in many others as well. In fact, immigration is an international issue: 3 percent of the world's population, 191,000,000 people, now live in countries other than those in which they were born. This paper discusses why immigration is so fraught, the relation of the crisis over immigration to the growing fracture of the Western world's economy, as well as to terrorism like September 11 and the train bombings in Madrid, Mumbai, and London, and how these factors—growing economic disparity, immigration, and terrorism—have altered one of the basic cultural phenomena of the United States in the last three decades, namely, what we call multiculturalism.

  4. Immigration, ethnicity, and the pandemic.

    Science.gov (United States)

    Kraut, Alan M

    2010-04-01

    The influenza pandemic of 1918-1919 coincided with a major wave of immigration to the United States. More than 23.5 million newcomers arrived between 1880 and the 1920s, mostly from Southern and Eastern Europe, Asia, Canada, and Mexico. During earlier epidemics, the foreign-born were often stigmatized as disease carriers whose very presence endangered their hosts. Because this influenza struck individuals of all groups and classes throughout the country, no single immigrant group was blamed, although there were many local cases of medicalized prejudice. The foreign-born needed information and assistance in coping with influenza. Among the two largest immigrant groups, Southern Italians and Eastern European Jews, immigrant physicians, community spokespeople, newspapers, and religious and fraternal groups shouldered the burden. They disseminated public health information to their respective communities in culturally sensitive manners and in the languages the newcomers understood, offering crucial services to immigrants and American public health officials. PMID:20568574

  5. Parallelization and checkpointing of GPU applications through program transformation

    Energy Technology Data Exchange (ETDEWEB)

    Solano-Quinde, Lizandro Damian [Iowa State Univ., Ames, IA (United States)

    2012-01-01

    GPUs have emerged as a powerful tool for accelerating general-purpose applications. The availability of programming languages that makes writing general-purpose applications for running on GPUs tractable have consolidated GPUs as an alternative for accelerating general purpose applications. Among the areas that have benefited from GPU acceleration are: signal and image processing, computational fluid dynamics, quantum chemistry, and, in general, the High Performance Computing (HPC) Industry. In order to continue to exploit higher levels of parallelism with GPUs, multi-GPU systems are gaining popularity. In this context, single-GPU applications are parallelized for running in multi-GPU systems. Furthermore, multi-GPU systems help to solve the GPU memory limitation for applications with large application memory footprint. Parallelizing single-GPU applications has been approached by libraries that distribute the workload at runtime, however, they impose execution overhead and are not portable. On the other hand, on traditional CPU systems, parallelization has been approached through application transformation at pre-compile time, which enhances the application to distribute the workload at application level and does not have the issues of library-based approaches. Hence, a parallelization scheme for GPU systems based on application transformation is needed. Like any computing engine of today, reliability is also a concern in GPUs. GPUs are vulnerable to transient and permanent failures. Current checkpoint/restart techniques are not suitable for systems with GPUs. Checkpointing for GPU systems present new and interesting challenges, primarily due to the natural differences imposed by the hardware design, the memory subsystem architecture, the massive number of threads, and the limited amount of synchronization among threads. Therefore, a checkpoint/restart technique suitable for GPU systems is needed. The goal of this work is to exploit higher levels of parallelism and

  6. Nation and Immigration

    Directory of Open Access Journals (Sweden)

    Ali Behdad

    2005-08-01

    Full Text Available In my paper, I wish to offer a critical assessment of the cultural and political implications of postcolonial and cultural critics’ abandonment of situated terms like immigration, citizenship, race, state, and their celebratory embracing of such unmoored notions as nomadism, deterritorialization, exile, hybridy, and postnation. On the one hand, I hope to demonstrate that postcolonial critics’ valorization of displacement’s redemptive power mystifies the oppositional possibilities of hybrid consciousness. On the other, I wish to argue that such theoretical projects fail to both historicize the particularities of postcolonial cultural formations and the importance of the politics of location in describing various manifestations of the global.

  7. California Immigrants Today

    OpenAIRE

    Cornelius, Wayne A.

    1990-01-01

    This paper will focus on the Mexico-origin component of the California immigrant population. Drawing on the results of field studies conducted throughout California and in west-central Mexico during the last ten years,the paper will describe how the profile of Mexican migration to California has changed since the 197Os, suggest explanations for these changes, and discuss their implications for public policy. Effects of the long-running economic crisis in Mexico and of the 1986 U.S. immigra-ti...

  8. Fueling the engine and releasing the break:combinational therapy of cancer vaccines and immune checkpoint inhibitors

    Institute of Scientific and Technical Information of China (English)

    Jennifer Kleponis; Richard Skelton; Lei Zheng

    2015-01-01

    Immune checkpoint inhibitors are increasingly drawing much attention in the therapeutic development for cancer treatment. However, many cancer patients do not respond to treatments with immune checkpoint inhibitors, partly because of the lack of tumor-inifltrating effector T cells. Cancer vaccines may prime patients for treatments with immune checkpoint inhibitors by inducing effector T-cell infiltration into the tumors and immune checkpoint signals. The combination of cancer vaccine and an immune checkpoint inhibitor may function synergistically to induce more effective antitumor immune responses, and clinical trials to test the combination are currently ongoing.

  9. 8 CFR 1240.41 - Immigration judges.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Immigration judges. 1240.41 Section 1240.41 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION..., 1997) § 1240.41 Immigration judges. (a) Authority. In any proceeding conducted under this part...

  10. 8 CFR 1240.1 - Immigration judges.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Immigration judges. 1240.1 Section 1240.1 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION... Immigration judges. (a) Authority. (1) In any removal proceeding pursuant to section 240 of the Act,...

  11. The Changing Face of Immigration Law.

    Science.gov (United States)

    Nugent, Christopher

    2001-01-01

    Focuses on laws that influence U.S. immigration, such as the Illegal Immigration Reform and Immigrant Responsibility Act (1996), the Personal Responsibility and Work Opportunity Reconciliation Act (1996), the Anti-Terrorism and Effective Death Penalty Act (1996), and the Legal Immigration and Family Equity Act (2000). Includes discussion…

  12. A novel role for the GTPase-activating protein Bud2 in the spindle position checkpoint.

    Directory of Open Access Journals (Sweden)

    Scott A Nelson

    Full Text Available The spindle position checkpoint (SPC ensures correct mitotic spindle position before allowing mitotic exit in the budding yeast Saccharomyces cerevisiae. In a candidate screen for checkpoint genes, we identified bud2Δ as deficient for the SPC. Bud2 is a GTPase activating protein (GAP, and the only known substrate of Bud2 was Rsr1/Bud1, a Ras-like GTPase and a central component of the bud-site-selection pathway. Mutants lacking Rsr1/Bud1 had no checkpoint defect, as did strains lacking and overexpressing Bud5, a guanine-nucleotide exchange factor (GEF for Rsr1/Bud1. Thus, the checkpoint function of Bud2 is distinct from its role in bud site selection. The catalytic activity of the Bud2 GAP domain was required for the checkpoint, based on the failure of the known catalytic point mutant Bud2(R682A to function in the checkpoint. Based on assays of heterozygous diploids, bud2(R682A, was dominant for loss of checkpoint but recessive for bud-site-selection failure, further indicating a separation of function. Tem1 is a Ras-like protein and is the critical regulator of mitotic exit, sitting atop the mitotic exit network (MEN. Tem1 is a likely target for Bud2, supported by genetic analyses that exclude other Ras-like proteins.

  13. Probabilistic Checkpointing Protocol to Sensor Network Fault-Tolerant

    Directory of Open Access Journals (Sweden)

    Titouna Faiza

    2012-09-01

    Full Text Available A wireless sensor network WSN is a collection of autonomous sensors nodes organized into a cooperative network. A sensor node transmits the data quantity to the sink. Indeed, a failed sink may abort the overall mission of the network. Due to their crucial functions, sinks must be designed and maintained to be robust enough in order to face trouble coming from the harsh environment. Thus, as a keystone of a WSN, a sink has to be provided with ability to recover from failures. In this paper, we propose a new protocol avoiding to the sink to be a central point of failure. First, we model a sensor node failure estimation problem through a causal network. Then, we show how the checkpointing process ensures the recovery of the network. This approach reduces both energy consumption and communication bandwidth requirements, and prolongs the lifetime of WSN. Interesting results are given by simulation

  14. EMODnet MedSea Checkpoint for sustainable Blue Growth

    Science.gov (United States)

    Moussat, Eric; Pinardi, Nadia; Manzella, Giuseppe; Blanc, Frederique

    2016-04-01

    The EMODNET checkpoint is a wide monitoring system assessment activity aiming to support the sustainable Blue Growth at the scale of the European Sea Basins by: 1) Clarifying the observation landscape of all compartments of the marine environment including Air, Water, Seabed, Biota and Human activities, pointing out to the existing programs, national, European and international 2) Evaluating fitness for use indicators that will show the accessibility and usability of observation and modeling data sets and their roles and synergies based upon selected applications by the European Marine Environment Strategy 3) Prioritizing the needs to optimize the overall monitoring Infrastructure (in situ and satellite data collection and assembling, data management and networking, modeling and forecasting, geo-infrastructure) and release recommendations for evolutions to better meet the application requirements in view of sustainable Blue Growth The assessment is designed for : - Institutional stakeholders for decision making on observation and monitoring systems - Data providers and producers to know how their data collected once for a given purpose could fit other user needs - End-users interested in a regional status and possible uses of existing monitoring data Selected end-user applications are of paramount importance for: (i) the blue economy sector (offshore industries, fisheries); (ii) marine environment variability and change (eutrophication, river inputs and ocean climate change impacts); (iii) emergency management (oil spills); and (iv) preservation of natural resources and biodiversity (Marine Protected Areas). End-user applications generate innovative products based on the existing observation landscape. The fitness for use assessment is made thanks to the comparison of the expected product specifications with the quality of the product derived from the selected data. This involves the development of checkpoint information and indicators based on Data quality and

  15. Attachment issues: kinetochore transformations and spindle checkpoint silencing.

    Science.gov (United States)

    Etemad, Banafsheh; Kops, Geert J P L

    2016-04-01

    Cell division culminates in the segregation of duplicated chromosomes in opposite directions prior to cellular fission. This process is guarded by the spindle assembly checkpoint (SAC), which prevents the anaphase of cell division until stable connections between spindle microtubules and the kinetochores of all chromosomes are established. The anaphase inhibitor is generated at unattached kinetochores and inhibitor production is prevented when microtubules are captured. Understanding the molecular changes in the kinetochore that are evoked by microtubule attachments is crucial for understanding the mechanisms of SAC signaling and silencing. Here, we highlight the most recent findings on these events, pinpoint some remaining mysteries, and argue for incorporating holistic views of kinetochore dynamics in order to understand SAC silencing. PMID:26947988

  16. Checkpoint inhibition for colorectal cancer: progress and possibilities.

    Science.gov (United States)

    Paul, Barry; O'Neil, Bert H; McRee, Autumn J

    2016-06-01

    Colorectal cancer (CRC) remains the third most common cause of cancer death in the USA. Despite an increase in the repertoire of treatment options available for CRC, median overall survival has plateaued at approximately 2.5 years. Strategies that engage the patient's native immune system to overcome checkpoint inhibition have proven to be promising in subsets of CRCs, specifically those with mismatch repair deficiency. Further studies are required to determine combinations of standard therapies with immunotherapy drugs and to discover the best biomarkers to predict response. This review provides insight into the progress made in treating patients with advanced CRC with immunotherapeutics and the areas that demand further research to make these drugs more effective in this patient population. PMID:27197538

  17. Checkpoint Blockade in Cancer Immunotherapy: Squaring the Circle

    Directory of Open Access Journals (Sweden)

    Maria A.V. Marzolini

    2015-03-01

    Full Text Available Manipulating the complex interaction between the immune system and tumour cells has been the focus of cancer research for many years, but it is only in the past decade that significant progress has been made in the field of cancer immunotherapy resulting in clinically effective treatments. The blockade of co-inhibitory immune checkpoints, essential for maintaining lymphocyte homeostasis and self-tolerance, by immunomodulatory monoclonal antibodies has resulted in the augmentation of anti-tumour responses. The greatest successes so far have been seen with the blockade of cytotoxic T lymphocyte associated antigen-4, which has resulted in the first Phase III clinical trial showing an overall survival benefit in metastatic melanoma, and in the blockade of the programmed cell death protein-1 axis. This concise review will focus on the clinical advances made by the blockade of these two pathways and their role in current cancer treatment strategies.

  18. Crime and Immigration: Evidence from Large Immigrant Waves

    OpenAIRE

    Bell, B.; Fasani, F.; Machin, S.

    2010-01-01

    This paper examines the relationship between immigration and crime in a setting where large migration flows offer an opportunity to carefully appraise whether the populist view that immigrants cause crime is borne out by rigorous evidence. We consider possible crime effects from two large waves of immigration that recently occurred in the UK. The first of these was the late 1990s/early 2000s wave of asylum seekers, and the second the large inflow of workers from EU accession countries that to...

  19. A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint

    DEFF Research Database (Denmark)

    van Vugt, Marcel A T M; Gardino, Alexandra K; Linding, Rune; Ostheimer, Gerard J; Reinhardt, H Christian; Ong, Shao-En; Tan, Chris S; Miao, Hua; Keezer, Susan M; Li, Jeijin; Pawson, Tony; Lewis, Timothy A; Carr, Steven A; Smerdon, Stephen J; Brummelkamp, Thijn R; Yaffe, Michael B

    2010-01-01

    DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While activation of DNA damage checkpoints has been studied extensively, molecular...

  20. NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling

    DEFF Research Database (Denmark)

    Sørensen, Claus Storgaard; Melixetian, Marina; Klein, Ditte Kjaersgaard;

    2010-01-01

    The DNA damage induced G(2)/M checkpoint is an important guardian of the genome that prevents cell division when DNA lesions are present. The checkpoint prevents cells from entering mitosis by degrading CDC25A, a key CDK activator. CDC25A proteolysis is controlled by direct phosphorylation events...... required for beta-TrCP mediated CDC25A polyubiquitylation and degradation. The activity of NEK11 is in turn controlled by CHK1 that activates NEK11 via phosphorylation on serine 273. Since inhibition of NEK11 activity forces checkpoint-arrested cells into mitosis and cell death, NEK11 is, like CHK1, a...

  1. The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor

    OpenAIRE

    Ivanova, Tsvetomira Georgieva, 1978-; Alves-Rodrigues, Isabel; G??mez Escoda, Blanca; Dutta, Chaitali; DeCaprio, James A.; Rhind, Nick; Hidalgo Hernando, Elena; Ayt?? del Olmo, Jos??

    2013-01-01

    In fission yeast cells, Cds1 is the effector kinase of the DNA replication checkpoint. We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1 is phosphorylated and inactivated by Cds1, resulting in activation of MluI-binding factor (MBF)-dependent transcription. This is essential to reinitiate DNA synthesis and for correct G1-to-S transition. Here we show that Cdc10, which is an essential part of the MBF core, is the target of the DNA damage checkpoint....

  2. Immigration adjudication reform: the case for automation

    OpenAIRE

    Sanford, Abigail J.

    2014-01-01

    Approved for public release; distribution is unlimited A bill that has passed the United States Senate, S. 744, proposes a Lawful Prospective Immigrant (LPI) status and a path to Citizenship for an estimated 11–12 million undocumented immigrants in the United States. United States Citizenship and Immigration Services (USCIS) is the agency that would be responsible for processing applications for LPI status or other immigration benefits authorized by immigration reform legislation or admini...

  3. Immigrants and Gender Roles: Assimilation vs. Culture

    OpenAIRE

    Francine D. Blau

    2015-01-01

    This paper examines evidence on the role of assimilation versus source country culture in influencing immigrant women's behavior in the United States – looking both over time with immigrants' residence in the United States and across immigrant generations. It focuses particularly on labor supply but, for the second generation, also examines fertility and education. We find considerable evidence that immigrant source country gender roles influence immigrant and second generation women's behavi...

  4. The Slump and Immigration Policy in Europe

    OpenAIRE

    Hatton, Timothy J.

    2014-01-01

    Historical experience suggests that when a period of rising immigration is followed by a sudden slump, this can trigger a policy backlash. This has not occurred in the current recession. This paper examines three links in the chain between the slump and immigration policy. First, although immigration flows have responded to the slump, and immigrants have borne more than their share of the burden, this has done little to protect the employment of non-immigrants. Second, despite the recession f...

  5. Immigration and Housing Booms: Evidence from Spain

    OpenAIRE

    Gonz??lez Luna, Libertad; Ortega, Francesc

    2009-01-01

    We estimate empirically the effect of immigration on house prices and residential construction activity in Spain over the period 1998-2008. This decade is characterized by both a spectacular housing market boom and a stunning immigration wave. We exploit the variation in immigration across Spanish provinces and construct an instrument based on the historical location patterns of immigrants by country of origin. The evidence points to a sizeable causal effect of immigration on b...

  6. Suicide Attempts among Immigrants in Europe

    OpenAIRE

    Bursztein Lipsicas, Cendrine

    2012-01-01

    Introduction and Aims: Immigrants comprise about 10% of the total population of Europe, but our knowledge about their suicidal behaviour is still insufficient. This study presents an overview of suicidal behaviour of immigrants in Europe compared to host populations focusing on: (I) The frequencies of attempted suicide, compared between immigrants and their hosts, between different immigrant groups, and between immigrants and their countries of origin, (II) the variations of these frequencies...

  7. Economic Impacts of Immigration: A Survey

    OpenAIRE

    Sari Pekkala

    2005-01-01

    This survey presents findings from recent empirical studies on economic impacts of immigration with particular emphasis on European and Nordic countries. The survey consists of three parts. First, we look at the extent of immigration as an economic phenomenon in various host countries. The second part deals with the assimilation of immigrant workers in host country labor markets and the use of social benefits by immigrants. Third, the effect of immigration on natives? labor market outcomes is...

  8. Evidence of New Immigrant Assimilation in Canada

    OpenAIRE

    Mary L. Grant

    1999-01-01

    Previous studies of the labour market experience of male immigrants to Canada have uncovered two disturbing trends: declining entry earnings for successive new immigrant cohorts and low assimilation rates. These findings suggest that many of these cohorts may never assimilate. The 1991 Census provides a first look at the immigrant cohorts arriving in the 1980s. These immigrants appear to avoid the plight of their predecessors; entry earnings have stopped falling, and those immigrants arriving...

  9. Employment Assimilation of Immigrants in the Netherlands

    OpenAIRE

    Zorlu, Aslan; Hartog, Joop

    2008-01-01

    This discussion Paper led to a publication in International Journal of Population Research , Vol. 2012, article ID 634276. Using two Dutch labour force surveys, employment assimilation of immigrants is examined. We observe marked differences between immigrants by source country. Non-western immigrants never reach parity with native Dutch. Even second generation immigrants never fully catch up. Caribbean immigrants, who share a colonial history with the Dutch, assimilate relatively quick compa...

  10. Immigrants on Welfare: Assimilation and Benefit Substitution

    OpenAIRE

    Ekhaugen, Tyra

    2005-01-01

    Non-western immigrants in Norway are shown to rely heavily on welfare transfers for several years after immigration. While refugee immigrants assimilate slightly out of welfare, other non-western immigrants assimilate rapidly into welfare. Re-migration is selective for both non-western and western immigrants, insofar as the probability of re-migration correlates negatively with the probability of receiving welfare. We argue that previous studies may have reached biased estimates of welfare as...

  11. Immigration, amnesties and the shadow economy

    OpenAIRE

    Bracco, Emanuele; ONNIS, LUISANNA

    2016-01-01

    This paper investigates the effects of immigration and immigration amnesties on the shadow economy. We find a robust and positive relationship between the presence of immigrants and the unobserved economic activity at the local level, but the implementation of a large immigration amnesty substantially weakens this link. Our analysis exploits newly compiled datasets of Italian immigration and shadow economy estimates for the years 1995-2006, comprising a panel of local-level aggregate statisti...

  12. Immigrant unemployment: the Australian experience.

    Science.gov (United States)

    Miller, P W; Neo, L M

    1997-01-01

    "Between 1980 and 1996 both male and female immigrants experienced higher unemployment rates than Australia-born workers....A multivariate analysis is used in this article to examine unemployment rate differentials between Australia-born and immigrants from English-speaking countries and immigrants from non-English-speaking countries. A feature of the analysis is decomposition of unemployment rate differences between birthplace groups into a component attributable to the different characteristics of the birthplace groups (e.g. different mean levels of education) and a part that is viewed as an impact associated simply with being foreign born." (EXCERPT) PMID:12292381

  13. Pre- to Post-Immigration Alcohol Use Trajectories among Recent Latino Immigrants

    OpenAIRE

    Sanchez, Mariana; La Rosa, Mario; Blackson, Timothy C.; Sastre, Francisco; Rojas, Patria; Li, Tan; Dillon, Frank

    2014-01-01

    The escalation of alcohol use among some Latino immigrant groups as their time in the United States increases has been well-documented. Yet, little is known about the alcohol use behaviors of Latino immigrants prior to immigration. This prospective longitudinal study examines pre- to post-immigration alcohol use trajectories among a cohort of recent Latino immigrants. Retrospective pre-immigration data were collected at baseline from a sample of 455 Cuban, South American and Central American ...

  14. Immigration Policy and the Skills of Immigrants to Australia, Canada, and the United States

    OpenAIRE

    Antecol, Heather; Cobb-Clark, Deborah A.; Stephen J. Trejo

    2001-01-01

    Census data for 1990/91 indicate that Australian and Canadian immigrants have higher levels of English fluency, education, and income (relative to natives) than do U.S. immigrants. This skill deficit for U.S. immigrants arises primarily because the United States receives a much larger share of immigrants from Latin America than do the other two countries. After excluding Latin American immigrants, the observable skills of immigrants are similar in the three countries. These patterns suggest t...

  15. Immigrant Assimilation And Welfare Participation: Do Immigrants Assimilate Into Or Out Of Welfare?

    OpenAIRE

    Hansen, Jörgen; Lofstrom, Magnus

    2000-01-01

    This paper analyses differences in welfare utilization between immigrants and natives in Sweden using a large panel data set, LINDA, for the years 1990 to 1996. Both welfare expenditures and immigration increased substantially in Sweden in the 1990's. We find that immigrants use welfare to a greater extent than natives and that non-refugee immigrants utilize social assistance less than refugee immigrants. Differences in welfare participation and number of months on welfare between immigrants ...

  16. Differences in attitudes towards immigration between Australia and Germany: the role of immigration policy

    OpenAIRE

    Ueffing, Philipp; Rowe, Francisco; Mulder, Clara H.

    2015-01-01

    "This paper investigates the connection between national immigration policy and a society's attitudes towards immigration. It argues that a country's immigration policy framework plays an important role in the formation of attitudes towards immigration by shaping the local national context of the receiving country. It examines the influence of a country's immigration policy framework by contrasting two countries - Australia and Germany - that developed remarkably different immigration policie...

  17. Immigrants' language skills: the immigrant experience in a longitudinal survey

    OpenAIRE

    Barry CHISWICK; Lee, Yew; Paul W. Miller

    2003-01-01

    This paper is concerned with the determinants of English language proficiency among immigrants. It presents a model based on economic incentives, exposure, and efficiency in language acquisition, which it tests using the Longitudinal Survey of Immigrants to Australia. Probit and bivariate probit analyses are employed. The hypotheses are supported by the data. The bivariate probit analysis across waves indicates a "regression to the mean" in the unobserved components of English language profic...

  18. Does Coordination of Immigration Policies among Destination Countries Increase Immigration?

    OpenAIRE

    Rose Skaksen, Jan; Malchow-Møller, Nikolaj; Aastrup Jensen, Claus

    2007-01-01

    We set up a theoretical model to analyze the implications of coordination of immigration policies among destination countries. The model contains two types of spill-overs between destination countries: A terms of trade externality and a welfare policy externality. We show that while coordination unambiguously increases welfare of the destination countries, the effects on the level of immigration and on the income distribution of natives are ambiguous. Thus, coordination among destination coun...

  19. Immigration and Muslim Immigrants: A Comparative Analysis of European States

    Directory of Open Access Journals (Sweden)

    Natasha T. Duncan

    2011-10-01

    Full Text Available Immigration policies serve a number of functions for states. Governments may use policies as instruments of foreign policy, economic growth, population growth, and/ or national security. In this post-September 11, 2001 global environment, integration policies have become more assimilationist and immigration restrictions toward nationals from Muslim countries of origin have increased in the name of national security. While this trend is common among many Western states, Britain’s immigration stance toward Muslim migrants remains unchanged. This study examines changes in policies toward immigrants—changes that make these policies de facto immigration policies though they may not have been conceived as such—in the Netherlands, Germany, France, and the absence of this change in the UK. It seeks to answer the question: what explains reforms in the Netherlands, Germany, and France while British immigration policy remained unchanged? In this effort, the article emphasizes the impact of these changes on potential migrants from predominantly Muslim countries of origin. Based on a comparative case study analysis using process tracing, findings indicate that Dutch immigration/integration policy choices influence government policy changes in other West European countries. Through a learning process, governments experiencing similar socio-political challenges observe overlapping societal responses to them and optimize in creating policy alternatives by using short-cuts and adopting policies implemented in comparable states and situations.

  20. Defining the optimal murine models to investigate immune checkpoint blockers and their combination with other immunotherapies.

    Science.gov (United States)

    Sanmamed, M F; Chester, C; Melero, I; Kohrt, H

    2016-07-01

    The recent success of checkpoint blockers to treat cancer has demonstrated that the immune system is a critical player in the war against cancer. Historically, anticancer therapeutics have been tested in syngeneic mouse models (with a fully murine immune system) or in immunodeficient mice that allow the engraftment of human xenografts. Animal models with functioning human immune systems are critically needed to more accurately recapitulate the complexity of the human tumor microenvironment. Such models are integral to better predict tumor responses to both immunomodulatory agents and directly antineoplastic therapies. In this regard, the development of humanized models is a promising, novel strategy that offers the possibility of testing checkpoint blockers' capacity and their combination with other antitumor drugs. In this review, we discuss the strengths and weaknesses of the available animal models regarding their capacity to evaluate checkpoint blockers and checkpoint blocker-based combination immunotherapy. PMID:26912558

  1. Coupling end resection with the checkpoint response at DNA double-strand breaks.

    Science.gov (United States)

    Villa, Matteo; Cassani, Corinne; Gobbini, Elisa; Bonetti, Diego; Longhese, Maria Pia

    2016-10-01

    DNA double-strand breaks (DSBs) are a nasty form of damage that needs to be repaired to ensure genome stability. The DSB ends can undergo a strand-biased nucleolytic processing (resection) to generate 3'-ended single-stranded DNA (ssDNA) that channels DSB repair into homologous recombination. Generation of ssDNA also triggers the activation of the DNA damage checkpoint, which couples cell cycle progression with DSB repair. The checkpoint response is intimately linked to DSB resection, as some checkpoint proteins regulate the resection process. The present review will highlight recent works on the mechanism and regulation of DSB resection and its interplays with checkpoint activation/inactivation in budding yeast. PMID:27141941

  2. Immigration process in catalytic medium

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The longtime behavior of the immigration process associated with a catalytic super-Brownian motion is studied. A large number law is proved in dimension d≤3 and a central limit theorem is proved for dimension d=3.

  3. Public Transit Use Among Immigrants

    OpenAIRE

    Heisz, Andrew; Schellenberg, Grant

    2004-01-01

    This paper examines the likelihood of immigrants and the Canadian-born to use public transit. It also discusses implications for public transit services. It uses data from the 1996 and 2001 censuses of Canada.

  4. The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA.

    OpenAIRE

    Lancelot, Nathalie; Charier, Gaëlle; Couprie, Joël; Duband-Goulet, Isabelle; Alpha-Bazin, Béatrice; Quémeneur, Eric; Ma, Emilie; Marsolier-Kergoat, Marie-Claude; Ropars, Virginie; Charbonnier, Jean-Baptiste; Miron, Simona; Craescu, Constantin,; Callebaut, Isabelle; Gilquin, Bernard; Zinn-Justin, Sophie

    2007-01-01

    DNA damage checkpoints are signal transduction pathways that are activated after genotoxic insults to protect genomic integrity. At the site of DNA damage, 'mediator' proteins are in charge of recruiting 'signal transducers' to molecules 'sensing' the damage. Budding yeast Rad9, fission yeast Crb2 and metazoan 53BP1 are presented as mediators involved in the activation of checkpoint kinases. Here we show that, despite low sequence conservation, Rad9 exhibits a tandem tudor domain structurally...

  5. Cambridge checkpoint English revision guide for the Cambridge secondary 1 test

    CERN Document Server

    Reynolds, John

    2013-01-01

    With Checkpoint English Revision Guide for the Cambridge Secondary 1 test you can aim for the best grade with the help of relevant and accessible notes, examiner advice plus questions and answers on each key topic. - Clear explanations of every topic covered in the Cambridge Secondary 1 Checkpoint English syllabus. - Builds revision skills you need for success in the test. - Exam tips wirtten by test setters and examiners giving you their expert advice. This text has not been through the Cambridge endorsement process.

  6. Cambridge checkpoint maths revision guide for the Cambridge secondary 1 test

    CERN Document Server

    Smith, Alan

    2013-01-01

    With Checkpoint Maths Revision Guide for the Cambridge Secondary 1 test you can aim for the best grade with the help of relevant and accessible notes, examiner advice plus questions and answers on each key topic. - Clear explanations of every topic covered in the Cambridge Secondary 1 Checkpoint Maths syllabus. - Builds revision skills you need for success in the test. - Exam tips wirtten by test setters and examiners giving you their expert advice. This text has not been through the Cambridge endorsement process.

  7. The pachytene checkpoint prevents accumulation and phosphorylation of the meiosis-specific transcription factor Ndt80

    OpenAIRE

    Tung, Kuei-Shu; Hong, Eun-Jin Erica; Roeder, G. Shirleen

    2000-01-01

    In budding yeast, many mutants defective in meiotic recombination and chromosome synapsis undergo checkpoint-mediated arrest at the pachytene stage of meiotic prophase. We recovered the NDT80 gene in a screen for genes whose overexpression bypasses the pachytene checkpoint. Ndt80 is a meiosis-specific transcription factor that promotes expression of genes required for exit from pachytene and entry into meiosis I. Herein, we show that the Ndt80 protein accumulates a...

  8. A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint

    OpenAIRE

    Hong, Eun-Jin Erica; Roeder, G. Shirleen

    2002-01-01

    The pachytene checkpoint prevents meiotic cell cycle progression in response to unrepaired recombination intermediates. We show that Ddc1 is required for the pachytene checkpoint in Saccharomyces cerevisiae. During meiotic prophase, Ddc1 localizes to chromosomes and becomes phosphorylated; these events depend on the formation and processing of double-strand breaks (DSBs). Ddc1 colocalizes with Rad51, a DSB-repair protein, indicating that Ddc1 associates with sites of DSB repair. The Rad24 che...

  9. "Hospitality and the Immigration Crisis"

    OpenAIRE

    Tobin, RW

    2016-01-01

    The recent debate in the United States over the wisdom of “Sanctuary Cities” for undocumented immigrants has once again cast the spotlight on the multiple crises caused by immigration, whether forced or not. The reactions have been strikingly different at the national and international levels. Because the responses are from governments and, therefore, political in nature, they have been contradictory and unsatisfactory. The situation cries out for a return to a belief in and practice of an at...

  10. The Economic Progress of Immigrants

    OpenAIRE

    George J. Borjas

    1998-01-01

    This paper presents a theoretical and empirical study of the economic progress experienced by immigrants in the U.S. labor market. The theoretical framework illustrates that the relationship between the entry wage of immigrants and the subsequent rate of wage growth depends on the technology of the human capital production function, particularly the extent of substitution or complementarity between pre-existing' human capital and post-migration investments. The empirical analysis uses the 197...

  11. Voting on Mass Immigration Restriction

    OpenAIRE

    Francesco Magris; Giuseppe Russo

    2004-01-01

    We study how immigration policies are determined under voting in a model where immigration redistributes income from wages to capital. Migration decisions are endogenous, there exist border enforcement costs and preference for home-country consumption. We model the migration policy as a pure entry rationing rather than a necessarily porous screening system. Unlike the existing results of polarization, our findings show that preferences about frontier closure are distributed on a continuum, go...

  12. Skills, Immigration and Selective Policies

    OpenAIRE

    Stefano Bosi; Eleni Iliopulos; Francesco Magris

    2006-01-01

    This paper analyzes the decision process that leads destination countries to introduce selective immigration policies based on skills requirements. We show that in absence of policy implementation costs, preferences in destination countries are polarized between complete openness or complete closure. However, this result changes if we take into account policy implementation costs. In presence of enforcement costs, selective immigration policies consist in positive quotas both for skilled and ...

  13. Immigrant Adaptation and Acculturation Orientations

    OpenAIRE

    Bereza, Monika, 1971-

    2010-01-01

    The goal of this study was to examine the five acculturation orientations: assimilationism, segregationism, exclusionism, individualism and itegrationism toward Polish immigrants. The Host Community Acculturation Scale was used to measure those orientations. This study also called for research on better understanding of dimensions of Polish culture. Ideas are proposed for better co- operation between immigrants and host members. Results showed with the Icelandic students host majority memb...

  14. Immigrant Entrepreneurs in Silicon Valley

    OpenAIRE

    Saxenian, AnnaLee; Edulbehram, Jumbi

    1998-01-01

    This anicle documents the growing presence of highly educated and technically skilled Indian and Chinese immigrants in the Silicon Valle y workforce. These immigrants are employed in the high-tech sectors of the economy at greater rates than the general population, are more likely to work in manufacturing than services, and have a greater degree of professional employment than the norm. Census and corporate data suggest that Indian- and Chinese-run businesses are already a substan tial force ...

  15. Economic Integration of Immigrant Entrepreneurs

    OpenAIRE

    Nonna Kushnirovich

    2016-01-01

    Objective: This study investigates economic integration of immigrant entrepreneurs by comparing them with their native-born counterparts, and examines whether and how entrepreneurs’ socio-cultural integration affects their economic integration. Research Design & Methods: This study is based on data of the Social Surveys conducted by the Israeli Central Bureau of Statistics in 2008, 2010 and 2012. The sample included 1133 native-born and 576 immigrant entrepreneurs. Findings: :Socio-cultural i...

  16. Immigrants' Income and Family Migration

    OpenAIRE

    Rashid, Saman

    2004-01-01

    This thesis consists of three papers studying the economic situation of immigrants in Sweden in terms of wage earnings, labor participation and family internal migration. Paper [I] studies the determinants of the wage earnings for immigrants from different countries, and secondly whether their wage earnings converge to those of comparable native-born Swedes. The study is based on a longitudinal dataset, and the data refers to 1991 and 1995, respectively. The empirical results indicate that im...

  17. A Minimum-Process Coordinated Checkpointing Protocol For Mobile Distributed System

    Directory of Open Access Journals (Sweden)

    Praveen Kumar

    2010-05-01

    Full Text Available While dealing with Mobile Distributed systems, we come across some issues like: mobility, low bandwidth of wireless channels and lack of stable storage on mobile nodes, disconnections, limited battery power and high failure rate of mobile nodes. These issues make traditional checkpointing techniques designed for Distributed systems unsuitable for Mobile environments. In this paper, we design a minimum process algorithm for Mobile Distributed systems, where no useless checkpoints are taken and an effort has been made to optimize the blocking of processes. We propose to delay the processing of selective messages at the receiver end only during the checkpointing period. A Process is allowed to perform its normal computations and send messages during its blocking period. In this way, we try to keep blocking of processes to bare minimum. We captured the transitive dependencies during the normal execution by piggybacking dependency vectors onto computational messages. In this way, we try to reduce the Checkpointing time by avoiding formation of Checkpointing tree. The Z-dependencies are well taken care of. The proposed scheme forces zero useless checkpoints at the cost of very small blocking.

  18. Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins

    Science.gov (United States)

    Gaspar, Miguel; Shenk, Thomas

    2006-02-01

    The DNA damage checkpoint pathway responds to DNA damage and induces a cell cycle arrest to allow time for DNA repair. Several viruses are known to activate or modulate this cellular response. Here we show that the ataxia-telangiectasia mutated checkpoint pathway, which responds to double-strand breaks in DNA, is activated in response to human cytomegalovirus DNA replication. However, this activation does not propagate through the pathway; it is blocked at the level of the effector kinase, checkpoint kinase 2 (Chk2). Late after infection, several checkpoint proteins, including ataxia-telangiectasia mutated and Chk2, are mislocalized to a cytoplasmic virus assembly zone, where they are colocalized with virion structural proteins. This colocalization was confirmed by immunoprecipitation of virion proteins with an antibody that recognizes Chk2. Virus replication was resistant to ionizing radiation, which causes double-strand breaks in DNA. We propose that human CMV DNA replication activates the checkpoint response to DNA double-strand breaks, and the virus responds by altering the localization of checkpoint proteins to the cytoplasm and thereby inhibiting the signaling pathway. ionizing radiation | ataxia-telangiectasia mutated pathway

  19. A Cdc2 dependent checkpoint maintains diploidy in Drosophila.

    Science.gov (United States)

    Hayashi, S

    1996-04-01

    DNA replication in G2 does not normally occur due to the checkpoint control. To elucidate its mechanism, the functions of the escargot and Dmcdc2 genes of Drosophila were studied. When escargot function was eliminated, diploid imaginal cells that were arrested in G2 lost Cyclin A, a regulatory subunit of G2/M cdk, and entered an endocycle. escargot genetically interacted with Dmcdc2 which encodes a catalytic subunit of G2/M cdk. The mutant phenotypes of Dmcdc2 itself was similar to those of escargot: many diploid cells in imaginal discs, salivary glands and the central nervous system entered an endocycle and sometimes formed polytene chromosomes. Since mitotically quiescent abdominal histoblasts still required Dmcdc2 to remain diploid, the inhibitory activity of G2/M cdk on DNA replication appeared to be separable from its activity as the mitosis promoting factor. These results suggest that in G2, escargot is required to maintain a high level of G2/M cdk that actively inhibits the entry into S phase. PMID:8620832

  20. Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena.

    Science.gov (United States)

    Sandoval, Pamela Y; Lee, Po-Hsuen; Meng, Xiangzhou; Kapler, Geoffrey M

    2015-07-01

    The intra-S phase checkpoint kinase of metazoa and yeast, ATR/MEC1, protects chromosomes from DNA damage and replication stress by phosphorylating subunits of the replicative helicase, MCM2-7. Here we describe an unprecedented ATR-dependent pathway in Tetrahymena thermophila in which the essential pre-replicative complex proteins, Orc1p, Orc2p and Mcm6p are degraded in hydroxyurea-treated S phase cells. Chromosomes undergo global changes during HU-arrest, including phosphorylation of histone H2A.X, deacetylation of histone H3, and an apparent diminution in DNA content that can be blocked by the deacetylase inhibitor sodium butyrate. Most remarkably, the cell cycle rapidly resumes upon hydroxyurea removal, and the entire genome is replicated prior to replenishment of ORC and MCMs. While stalled replication forks are elongated under these conditions, DNA fiber imaging revealed that most replicating molecules are produced by new initiation events. Furthermore, the sole origin in the ribosomal DNA minichromosome is inactive and replication appears to initiate near the rRNA promoter. The collective data raise the possibility that replication initiation occurs by an ORC-independent mechanism during the recovery from HU-induced replication stress. PMID:26218270

  1. The Meiotic Recombination Checkpoint Suppresses NHK-1 Kinase to Prevent Reorganisation of the Oocyte Nucleus in Drosophila

    OpenAIRE

    Lancaster, Oscar M.; Breuer, Manuel; Cullen, C. Fiona; Ito, Takashi; Ohkura, Hiroyuki

    2010-01-01

    The meiotic recombination checkpoint is a signalling pathway that blocks meiotic progression when the repair of DNA breaks formed during recombination is delayed. In comparison to the signalling pathway itself, however, the molecular targets of the checkpoint that control meiotic progression are not well understood in metazoans. In Drosophila, activation of the meiotic checkpoint is known to prevent formation of the karyosome, a meiosis-specific organisation of chromosomes, but the molecular ...

  2. U.S. Citizenship and Immigration Services

    Science.gov (United States)

    ... Authorization All USCIS Forms Filing Fees USCIS Electronic Immigration System Order Forms by Mail Order Forms by ... Ask a Question, Get a Trusted Answer Find Immigration Options File Online Manage Your Case Check your ...

  3. Immigration and viral hepatitis.

    Science.gov (United States)

    Sharma, Suraj; Carballo, Manuel; Feld, Jordan J; Janssen, Harry L A

    2015-08-01

    WHO estimates reveal that the global prevalence of viral hepatitis may be as high as 500 million, with an annual mortality rate of up to 1.3 million individuals. The majority of this global burden of disease is borne by nations of the developing world with high rates of vertical and iatrogenic transmission of HBV and HCV, as well as poor access to healthcare. In 2013, 3.2% of the global population (231 million individuals) migrated into a new host nation. Migrants predominantly originate from the developing countries of the south, into the developed economies of North America and Western Europe. This mass migration of individuals from areas of high-prevalence of viral hepatitis poses a unique challenge to the healthcare systems of the host nations. Due to a lack of universal standards for screening, vaccination and treatment of viral hepatitis, the burden of chronic liver disease and hepatocellular carcinoma continues to increase among migrant populations globally. Efforts to increase case identification and treatment among migrants have largely been limited to small outreach programs in urban centers, such that the majority of migrants with viral hepatitis continue to remain unaware of their infection. This review summarizes the data on prevalence of viral hepatitis and burden of chronic liver disease among migrants, current standards for screening and treatment of immigrants and refugees, and efforts to improve the identification and treatment of viral hepatitis among migrants. PMID:25962882

  4. Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis

    Directory of Open Access Journals (Sweden)

    Moore Finola E

    2009-07-01

    Full Text Available Abstract The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications. For example, the timely polyubiquitination of critical mitotic regulators by Anaphase Promoting Complex/Cyclosome (APC/C is essential for the metaphase to anaphase transition and mitotic exit. The spindle assembly checkpoint prevents unscheduled activity of APC/C-Cdc20 in early mitosis, allowing bipolar attachment of kinetochores to mitotic spindle and facilitating equal segregation of sister chromatids. The critical effector of the spindle checkpoint, Mitotic arrest deficient 2 (Mad2, is recruited to unattached kinetochores forming a complex with other regulatory proteins to efficiently and cooperatively inhibit APC/C-Cdc20. A weakened and/or dysfunctional spindle checkpoint has been linked to the development of genomic instability in both cell culture and animal models, and evidence suggests that aberrant regulation of the spindle checkpoint plays a critical role in human carcinogenesis. Recent studies have illuminated a network of both degradative and non-degradative ubiquitination events that regulate the metaphase to anaphase transition and mitotic exit. Within this context, our recent work showed that the HECT (Homologous to E6-AP C-terminus-family E3 ligase Smurf2 (Smad specific ubiquitin regulatory factor 2, known as a negative regulator of transforming growth factor-beta (TGF-β signaling, is required for a functional spindle checkpoint by promoting the functional localization and stability of Mad2. Here we discuss putative models explaining the role of Smurf2 as a new regulator in the spindle checkpoint. The dynamic mitotic localization of Smurf2 to the centrosome and other critical mitotic structures provides implications about mitotic checkpoint control dependent on various ubiquitination events. Finally, deregulated Smurf2 activity may contribute to carcinogenesis by

  5. Economic Integration of Immigrant Entrepreneurs

    Directory of Open Access Journals (Sweden)

    Nonna Kushnirovich

    2016-01-01

    Full Text Available Objective: This study investigates economic integration of immigrant entrepreneurs by comparing them with their native-born counterparts, and examines whether and how entrepreneurs’ socio-cultural integration affects their economic integration. Research Design & Methods: This study is based on data of the Social Surveys conducted by the Israeli Central Bureau of Statistics in 2008, 2010 and 2012. The sample included 1133 native-born and 576 immigrant entrepreneurs. Findings: :Socio-cultural integration is not necessarily associated with economic integration and a high income. Immigrants can earn the same and even more than native-born entrepreneurs do, even if they have a low level of socio-cultural integration. The impact of socio-cultural integration on immigrant entrepreneurs’ income varies by their origin. Implications & Recommendations: Understanding integration of immigrant entrepreneurs and the factors affecting their income will help policy-makers to facilitate their economic advancement. Contribution & Value Added: Based on Berry’s concept, I propose a model of entrepreneurs’ integration. The model stresses interrelations between socio-cultural and economic integration.

  6. Exploring the Economic Determinants of Immigration Attitudes

    OpenAIRE

    Beth Miller

    2012-01-01

    This study explores the economic determinants of attitudes toward immigration across forty-seven countries. The extant research addressing public opinion on immigration tends to concentrate on Anglo attitudes toward immigrants in the United States or attitudes toward immigrants in Western Europe. Thus, empirical evidence currently draws from a limited pool including advanced industrial democracies. To more accurately and completely generalize statements regarding support for economic theories...

  7. The Immigrant Housing Market: Analyses for Australia

    OpenAIRE

    Jamie Chua; Paul W. Miller

    2005-01-01

    This paper examines the immigrant adjustment process in Australia from the perspective of the housing market. It shows that immigrant “catch-up” to the native born in the housing market is much more rapid than in the labour market. A decomposition of the estimated coefficients of a logit model of tenure choice is developed that gives formal recognition to the immigrant adjustment process. The results from this decomposition demonstrate the importance of taking account of immigrant adjustment ...

  8. [What is the effect of immigration policy?].

    Science.gov (United States)

    De Beer, J

    1998-08-01

    "In 1993 and 1994 the Dutch government took new measures in order to restrict immigration. The effect of these measures on the size of immigration is estimated by adding intervention variables to a regression model in which immigration is explained by a linear trend and the unemployment rate.... It is estimated that immigration in 1994-1997 was 20% lower than it would have been if the restrictive measures had not been taken." (EXCERPT) PMID:12294178

  9. Occupational segregation of immigrant women in Spain

    OpenAIRE

    Coral del Río; Olga Alonso-Villar

    2010-01-01

    The aim of this paper is to analyze occupational segregation in the Spanish labor market from a gender and an immigration perspective. In doing so, several local and overall segregation measures are used. Our results suggest that immigrant women in Spain suffer a double segregation since segregation affects them to a greater extent than it does either native women or immigrant men. There are, however, remarkable discrepancies among the segregation of immigrant women depending on their region ...

  10. Security and United States Immigration Policy

    OpenAIRE

    Totten, Robbie James

    2012-01-01

    What is the relationship between security and immigration to the United States? How do security objectives factor into U.S. immigration policy? These questions are significant for the U.S. because the volume of international migration has been increasing in recent years and without sound policy planning immigration will serve as a source of conflict with foreign states, tax the ability of domestic systems to assimilate diverse peoples without violence, and expose citizens and immigrants to cr...

  11. Immigration Policy and Macroeconomic Performance in France

    OpenAIRE

    Hippolyte D'Albis; Ekrame Boubtane; Dramane Coulibaly

    2015-01-01

    This paper quantitatively assesses the interaction between permanent immigration into France and France's macroeconomic performance as seen through its GDP per capita and its unemployment rate. It takes advantage of a new database where immigration is measured by the flow of newly-issued long-term residence permits, categorized by both the nationality of the immigrant and the reason of permit issuance. Using a VAR model estimation of monthly data over the period 1994-2008, we find that immigr...

  12. Development in Children of Immigrant Families.

    Science.gov (United States)

    Cowden, John D; Kreisler, Kelly

    2016-10-01

    Children of immigrant families experience developmental processes in the contexts of migration and settlement, presenting immigration-specific challenges. Child health providers can use awareness of the cultural-ecological model of immigrant child development to explore how acculturation, ethnic identity formation, and bilingualism affect the children and families under their care. Cross-cultural strategies for evaluating and supporting immigrant child development are presented to guide the provider in clinical interactions and community efforts. PMID:27565358

  13. INTEGRATION POLICY TOWARDS IMMIGRANTS: CURRENT EXPERIENCE

    OpenAIRE

    Nadiia Bureiko

    2012-01-01

    In the contemporary world the intensity of the immigration movements is constantly increasing. Countries which experience great immigrant flows are facing numerous problems which should be solved. The article studies the current immigration flows in EU countries, the United States of America and Canada and presents three main models of integration policy towards immigrants – political assimilation, functional integration and multicultural model. Separate models are distinguished for the Musli...

  14. Do Enclaves Matter in Immigrant Adjustment?

    OpenAIRE

    Chiswick, Barry R; Paul W. Miller

    2002-01-01

    This paper is concerned with the determinants and consequences of immigrant/linguistic concentrations (enclaves). The reasons for the formation of these concentrations are discussed. Hypotheses are developed regarding ?ethnic goods? and the effect of concentrations on the immigrant?s language skills, as well as the effects on immigrant earnings of destination language skills and the linguistic concentration. These hypotheses are tested using PUMS data from the 1990 U.S. Census on adult male i...

  15. The Netherlands : Old Emigrants - Young Immigrant Country

    OpenAIRE

    van Ours, J.C.; Veenman, J.M.C.

    1999-01-01

    Since the mid 1960s the Netherlands has an immigration surplus, mainly because of manpower recruitment from Turkey and Morocco and because of immigration from the former Dutch colony of Surinam. Immigrant workers have a weak labour market position, which is mainly related to their educational level and language skills. Children and grandchildren of immigrants are expected to have better chances to integrate into Dutch society. Nevertheless, specific policy measures are needed to avoid social ...

  16. Immigrant Health--Selectivity and Acculturation

    OpenAIRE

    Guillermina Jasso; Massey, Douglas S.; Rosenzweig, Mark R.; Smith, James P.

    2004-01-01

    This paper explores some salient issues concerning immigrant health. Ethnic health disparities are inherently linked to immigration since ethnic identities often are traced to the country of origin of one's immigrant ancestors. Two of the central questions that have dominated the medical and social science literature on immigrant health are the central focus of this paper. These issues involve the magnitude and mechanisms shaping health selectivity and the determinants of health trajectories ...

  17. Immigrant Unionization through the Great Recession

    OpenAIRE

    Catron, Peter

    2012-01-01

    Previous research finds that in recent years immigrants had a higher propensity to unionize than native-born workers. However, there is little research that shows historically marginalized immigrant workers are able to maintain newly acquired union jobs, especially during times unfavorable to unionization more generally. Therefore, this paper focuses on immigrant unionization during the Great Recession of 2008 to determine whether the inroads that immigrants have made through organizing are m...

  18. Assimilation and cohort effects for German immigrants

    OpenAIRE

    Gundel, Sebastian; Peters, Heiko

    2008-01-01

    Demographic change and the rising demand for highly qualified labor in Germany attracts notice to the analysis of immigration. In addition, the pattern of immigration changed markedly during the past decades. Therefore we use the latest data of the German Socioeconomic Panel up to the year 2006 in order to investigate the economic performance of immigrants. We perform regressions of three pooled cross sections (1986, 1996, 2006) to estimate assimilation and quality of immigrants as reflected ...

  19. Intermarriage and the Economic Assimilation of Immigrants

    OpenAIRE

    Xin Meng; Robert G Gregory

    2005-01-01

    This article investigates the assimilation role of intermarriage between immigrants and natives. Intermarried immigrants earn significantly higher incomes than endogamously married immigrants, even after we take account of human capital endowments and endogeneity of intermarriage. The premium does not appear to be a reward for unobservable individual characteristics. Natives who intermarry do not receive this premium, nor do immigrants who intermarry into another ethnic group. The premium is ...

  20. Employment Assimilation of Immigrants - Evidence from Finland

    OpenAIRE

    Hämäläinen, Kari; Kangasharju, Aki; Pekkala, Sari; Sarvimäki, Matti

    2005-01-01

    This paper analyses economic effects of immigrants that moved to Finland be-tween 1990 and 2000. The focus is on labour market participation, which affects direct taxes paid and income transfers received by immigrants. Immigrants are followed from the year of immigration up to 2000 or out-migration. Countries of origin are grouped into four categories: OECD, neighbouring countries (Russia and Estonia), the "JIIS-countries” (i.e. former Yugoslavia, Iran, Irak and Soma-lia), and remaining other...

  1. Immigration, Education and Labour Market Institutions

    OpenAIRE

    Christian Lumpe; Benjamin Weigert

    2004-01-01

    In this paper we analyse the effect of immigration on the labour market conditions for different skill groups. We develop a model of endogenous labour supply in which immigration affects educational decisions. We show how the skill premium changes with immigration of low skilled labour under flexible and rigid wages. Depending on the labour market institutions, immigration of low skilled labour is absorbed either by an increased skill premium or increased unemployment of low skilled labour. T...

  2. Mental health of immigrants and refugees.

    Science.gov (United States)

    Pumariega, Andrés J; Rothe, Eugenio; Pumariega, Joanne B

    2005-10-01

    The United States is a country of immigrants. With the exception of Native-Americans, every other American is, or descends from, an immigrant. First and second generation immigrant children are the most rapidly growing segment of the American population, with the great majority of this population being of non-European origin. This paper reviews the unique risk factors and mental health needs of our new immigrant populations, as well as treatment and services approaches to address their unique needs. PMID:16142540

  3. Immigration and the Distribution of Incomes

    OpenAIRE

    Francine D. Blau; Lawrence M. Kahn

    2012-01-01

    We review research on the impact of immigration on income distribution. We discuss routes through which immigration can affect income distribution in the host and source countries, including compositional effects and effects on native incomes. Immigration may affect the composition of skills among the residents of a country. Moreover, immigrants can, by changing relative factor supplies, affect native wage and employment rates and the return to capital. We then provide evidence on the level a...

  4. The Relationship Between Immigrant School Composition, Classmate Support and Involvement in Physical Fighting and Bullying among Adolescent Immigrants and Non-immigrants in 11 Countries

    DEFF Research Database (Denmark)

    Walsh, Sophie D; De Clercq, Bart; Molcho, Michal;

    2015-01-01

    percentage of immigrant adolescents in a school was related to higher levels of physical fighting and bullying perpetration for both immigrant and non-immigrant adolescents and lower levels of victimization for immigrants. In environments of low classmate support, the positive relationship between immigrant...... school composition and fighting was stronger for non-immigrants than in environments with high classmate support. In environments of low classmate support, the negative relationship between immigrant school composition and fighting and bullying victimization was stronger for immigrant adolescents than in...... influences levels of peer violence. The results highlight a need for school intervention programs encouraging positive relations in schools with immigrant populations....

  5. Do the Falling Earnings of Immigrants Apply to Self-employed Immigrants?

    OpenAIRE

    Frenette, Marc

    2002-01-01

    Many studies have examined the relative success of immigrant men in the (primarily paid) workforce. Despite the fact that they represent approximately one-sixth of the immigrant workforce, self-employed immigrants are a relatively understudied group. This study uses the 1981, 1986, 1991, and 1996 Census files to assess the success of self-employed immigrant men (compared with self-employed native-born men), using the relative success of paid immigrant men as the benchmark. After controlling f...

  6. Emigration of Immigrants and Measures of Immigrant Assimilation: Evidence from Sweden.

    OpenAIRE

    Edin, Per-Anders; Robert J. LaLonde; Åslund, Olof

    2000-01-01

    Most previously used measures of immigrant labor market assimilation will be biased if there is non-random emigration of immigrants. We use longitudinal data on immigration to Sweden 1970-1990 to examine the extent and pattern of immigrant emigration and its consequences for measures of assimilation. Large fractions of the immigrants leave the host country shortly after arrival; within five years, more than a quarter of the people studied emigrated. As expected, economic migrants are much mor...

  7. Immigrant versus natives ? displacement and job creation

    OpenAIRE

    Ozden, Caglar; Wagner, Mathis

    2014-01-01

    The impact of immigration on native workers is driven by two countervailing forces: the degree of substitutability between natives and immigrants, and the increased demand for native workers as immigrants reduce the cost of production and output expands. The literature so far has focused on the former substitution effect, while ignoring the latter scale effect. This paper estimates both of...

  8. Psychological Acculturation of Young Visible Immigrants.

    Science.gov (United States)

    Sam, David Lackland

    1992-01-01

    Discusses the psychological acculturation of young visible immigrants in Western industrialized countries, examining the psychosocial milieu that parents and society provide them, and the inability to assimilate or acculturate. "Visible" immigrant is a value neutral term for nonwhite or non-Caucasian immigrants. (SLD)

  9. Immigration and the transformation of American unionism

    NARCIS (Netherlands)

    B. Burgoon; J. Fine; W. Jacoby; D. Tichenor

    2010-01-01

    Does immigration hamper union organizing in the United States? The prevailing literature strongly suggests that it does and for two reasons: first, immigrants increase the labor pool and diminish union influence over the labor market. And second, immigrants may be harder to organize than native work

  10. Beyond "Culture Clash" Understandings of Immigrant Experiences

    Science.gov (United States)

    Ngo, Bic

    2008-01-01

    This article addresses the ways in which the experiences of immigrant youth and families in U.S. schools and society have been conceptualized primarily as conflicts between immigrant cultures and dominant U.S. culture. Exemplified by the discourse of culture clash or of immigrants being torn between two worlds, this prevalent understanding…

  11. Intergroup Relations and Predictors of Immigrant Experience

    Science.gov (United States)

    Danso, Kofi; Lum, Terry

    2013-01-01

    Using survey data from 1,036 participants, which included 4 immigrant groups, we examined the factors that influence immigrants' experiences as they interact with nonimmigrant Americans. Logistic and multinomial regression results indicate that non-European immigrants were more likely to report negative experiences with Americans. The odds of…

  12. 8 CFR 1003.10 - Immigration judges.

    Science.gov (United States)

    2010-01-01

    ... jurisdiction as provided in 8 CFR 1003.1. (d) Governing standards. Immigration judges shall be governed by the... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Immigration judges. 1003.10 Section 1003.10 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL...

  13. Culturally Competent Qualitative Research with Latino Immigrants

    Science.gov (United States)

    Ojeda, Lizette; Flores, Lisa Y.; Meza, Rocio Rosales; Morales, Alejandro

    2011-01-01

    This article provides recommendations for conducting culturally competent qualitative research with Latino immigrants, a historically exploited group that represents more than half of all U.S. immigrants and is continuously growing. Limited research exists on Latino immigrants despite their large presence in the United States. The authors draw…

  14. In-silico modeling of the mitotic spindle assembly checkpoint.

    Directory of Open Access Journals (Sweden)

    Bashar Ibrahim

    Full Text Available BACKGROUND: The Mitotic Spindle Assembly Checkpoint ((MSAC is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar attachments to the mitotic spindle. Its malfunction can lead to cancer. PRINCIPLE FINDINGS: We have constructed and validated for the human (MSAC mechanism an in silico dynamical model, integrating 11 proteins and complexes. The model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based on the Template Model, MCC formation, and APC inhibition. Originating from the biochemical reactions for the underlying molecular processes, non-linear ordinary differential equations for the concentrations of 11 proteins and complexes of the (MSAC are derived. Most of the kinetic constants are taken from literature, the remaining four unknown parameters are derived by an evolutionary optimization procedure for an objective function describing the dynamics of the APC:Cdc20 complex. MCC:APC dissociation is described by two alternatives, namely the "Dissociation" and the "Convey" model variants. The attachment of the kinetochore to microtubuli is simulated by a switching parameter silencing those reactions which are stopped by the attachment. For both, the Dissociation and the Convey variants, we compare two different scenarios concerning the microtubule attachment dependent control of the dissociation reaction. Our model is validated by simulation of ten perturbation experiments. CONCLUSION: Only in the controlled case, our models show (MSAC behaviour at meta- to anaphase transition in agreement with experimental observations. Our simulations revealed that for (MSAC activation, Cdc20 is not fully sequestered; instead APC is inhibited by MCC binding.

  15. The Europeanisation of immigration politics

    Directory of Open Access Journals (Sweden)

    Adrian Favell

    1998-12-01

    Full Text Available With the 1996-7 IGC and signing of the Amsterdam Treaty, immigration has moved towards the top of the EU policy agenda. This paper offers an overview of developments on immigration, asylum and citizenship. It goes on to develop a sociological approach to Europeanisation, which identifies the principle actors and organisations which constitute the emerging political field of immigration at the EU level. In particular, it discusses in detail the growing presence of NGOs in Brussels, and their strategies for influencing EU policy making. It also relates the success of these transnational organisations to other forms of transnational cooperation between networks of European police and security experts, and between region and city networks. To understand in sociological terms the specific forms of empowerment enabled to certain groups by European integration, it is necessary to show how successful actors in the European circles have created new forms of social and cultural capital beyond the nation state.

  16. Costs of berm and causeway alternatives

    International Nuclear Information System (INIS)

    Experiments initiated in February 1985 and still in progress have demonstrated that removal of 30 cm of topsoil brings the specific activity of Bikini Island soil down to the level of that on Eneu and reduces the external exposure rate to gamma rays from an average of 68 pr/h to 5 pr/h. The analytical data completed thus far for food crops grown in the experimental and control areas indicate a parallel response. During 1986 results became available showing that removal of topsoil would also limit productivity. However, it is now known that with adequate care the excavated plot can be as productive as the unexcavated (natural) one. The removal of 30 cm (1 foot) of topsoil at Bikini Island would produce large amounts of waste vegetable matter and approximately 719,000 cubic meters of contaminated topsoil. Three principal alternatives have been considered for the disposal of the spoil. The cost estimates for these and other rehabilitation alternatives were developed in detail by a panel of engineers, chaired by BARC member Arthur S. Kubo, which met in January 1986. The panel's report constitutes Appendix C of BARC Report No. 4

  17. Checkpoint Kinases Regulate a Global Network of Transcription Factors in Response to DNA Damage

    Directory of Open Access Journals (Sweden)

    Eric J. Jaehnig

    2013-07-01

    Full Text Available DNA damage activates checkpoint kinases that induce several downstream events, including widespread changes in transcription. However, the specific connections between the checkpoint kinases and downstream transcription factors (TFs are not well understood. Here, we integrate kinase mutant expression profiles, transcriptional regulatory interactions, and phosphoproteomics to map kinases and downstream TFs to transcriptional regulatory networks. Specifically, we investigate the role of the Saccharomyces cerevisiae checkpoint kinases (Mec1, Tel1, Chk1, Rad53, and Dun1 in the transcriptional response to DNA damage caused by methyl methanesulfonate. The result is a global kinase-TF regulatory network in which Mec1 and Tel1 signal through Rad53 to synergistically regulate the expression of more than 600 genes. This network involves at least nine TFs, many of which have Rad53-dependent phosphorylation sites, as regulators of checkpoint-kinase-dependent genes. We also identify a major DNA damage-induced transcriptional network that regulates stress response genes independently of the checkpoint kinases.

  18. Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance

    Directory of Open Access Journals (Sweden)

    Huilin Zhou

    2012-10-01

    Full Text Available In order to preserve genome integrity, extrinsic or intrinsic DNA damages must be repaired before they accumulate in cells and trigger other mutations and genome rearrangements. Eukaryotic cells are able to respond to different genotoxic stresses as well as to single DNA double strand breaks (DSBs, suggesting highly sensitive and robust mechanisms to detect lesions that trigger a signal transduction cascade which, in turn, controls the DNA damage response (DDR. Furthermore, cells must be able to distinguish natural chromosomal ends from DNA DSBs in order to prevent inappropriate checkpoint activation, DDR and chromosomal rearrangements. Since the original discovery of RAD9, the first DNA damage checkpoint gene identified in Saccharomyces cerevisiae, many genes that have a role in this pathway have been identified, including MRC1, MEC3, RAD24, RAD53, DUN1, MEC1 and TEL1. Extensive studies have established most of the genetic basis of the DNA damage checkpoint and uncovered its different functions in cell cycle regulation, DNA replication and repair, and telomere maintenance. However, major questions concerning the regulation and functions of the DNA damage checkpoint remain to be answered. First, how is the checkpoint activity coupled to DNA replication and repair? Second, how do cells distinguish natural chromosome ends from deleterious DNA DSBs? In this review we will examine primarily studies performed using Saccharomyces cerevisiae as a model system.

  19. Whose immigration reform ?

    OpenAIRE

    Feldman, David

    2014-01-01

    On October 8, 2013, thousands of migrants, community activists, religious leaders, and “pro-immigrant” politicians descended upon the National Mall and the Capitol building to demand that the US Congress pass so-called “comprehensive immigration reform.” Although two hundred protesters were arrested during the action, the Chicago-based Moratorium on Deportations remained unimpressed, and released a statement in which it decried the current “immigration reform” movement as a “scam,” and the Se...

  20. Immigration and unemployment in Australia.

    Science.gov (United States)

    Tsokhas, K

    1994-01-01

    "This article is presented in two parts. The first contains a discussion of Australia's migration programme, its different categories and changes in intakes. It also deals with the contribution made by immigration to the size of the labour force.... The second part deals with the effect of immigration on the unemployment rate and concludes that its effect is negligible or, at best, slightly positive.... Against this background the paper discusses factors contributing to the employment and unemployment experience of migrants, for whom English language proficiency and the possession of recognized skills and qualifications are important in determining employability." (SUMMARY IN FRE AND SPA) PMID:12289763

  1. Immigration Status and Criminal Behavior

    OpenAIRE

    Georgios Papadopoulos

    2013-01-01

    This paper studies the individual level relationship between immigration and property crime in England and Wales using crime self-reports from the Crime and Justice Survey. Binary and count data models that account for under-reporting of criminal activity are used, since under-reporting is a major concern in self-reported crime data. The results indicate that under-reporting is considerably large, but, if anything, immigrants are less likely to under-report than natives. They also reveal that...

  2. Job matching for Chinese and Asian Indian immigrants in Canada

    OpenAIRE

    Eric Fong; Peter Shi Jiao

    2013-01-01

    Using recently collected data from Toronto, a major city in Canada, we explored job mismatch among Chinese and Asian Indian immigrants. Our study shows that a relatively small percentage of Chinese immigrants, and an even lower percentage of Asian Indian immigrants, work in the same industry and occupation as they did before immigrating. The multivariate analysis suggests that higher education before immigration does help immigrants secure first jobs that match their jobs before immigration. ...

  3. Trade substitution and immigrant networks: can immigrants hurt trade?

    Czech Academy of Sciences Publication Activity Database

    Konečný, Tomáš

    Newcastle upon Tyne : Cambridge Scholars Publishing, 2008, s. 280-301. ISBN 978-1-4438-0038-9 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : immigrant networks * international trade * trade diversion Subject RIV: AH - Economics

  4. The adaptation of non-western and Muslim immigrant adolescents in the Netherlands: An immigrant paradox?

    Science.gov (United States)

    Van Geel, Mitch; Vedder, Paul

    2010-10-01

    This article addresses the possible existence of an immigrant paradox in a sample of immigrant adolescents attending vocational schools in the Netherlands. An immigrant paradox is the finding that first generation immigrants show a more positive pattern of adaptation than nationals despite poorer economic conditions. Second generation immigrants regress to the nationals in terms of adaptation. A sample of 152 first generation immigrant adolescents, 285 second generation immigrant adolescents and 406 national adolescents completed self-reports about socio-economic status, psychological problems, behavioral problems and self-esteem. The results supported the existence of an immigrant paradox in this sample. This indicates that further assimilation among immigrant adolescents does not necessarily lead to increased well being. PMID:20602739

  5. Immune checkpoints aberrations and gastric cancer; assessment of prognostic value and evaluation of therapeutic potentials.

    Science.gov (United States)

    Abdel-Rahman, Omar

    2016-01-01

    Till now, the prognosis of advanced gastric cancer looked dreadful; thus the search for newer better approaches for this lethal disease has been a strategic target for cancer researchers. In recent years, important immunobiological aspects of the tumor have been revealed with the subsequent proposal of immune check point inhibitors to target these pathways. Clinically, unselected use of immune checkpoint inhibitors in gastric cancer has been deemed with failure; in contrast to the clear success of more recent studies reporting on the use of pembrolizumab in molecularly selected patients. This may illustrate that any future use of immune checkpoint inhibitors in gastric cancer has to be molecularly supported. This review provides a delicate dissection of the clinical and immunobiological considerations underlying the use of these agents in addition to a thorough review of the published clinical data of immune checkpoint inhibitors in gastric cancer. PMID:26321371

  6. The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.

    Science.gov (United States)

    Dungrawala, Huzefa; Rose, Kristie L; Bhat, Kamakoti P; Mohni, Kareem N; Glick, Gloria G; Couch, Frank B; Cortez, David

    2015-09-17

    The ATR replication checkpoint ensures that stalled forks remain stable when replisome movement is impeded. Using an improved iPOND protocol combined with SILAC mass spectrometry, we characterized human replisome dynamics in response to fork stalling. Our data provide a quantitative picture of the replisome and replication stress response proteomes in 32 experimental conditions. Importantly, rather than stabilize the replisome, the checkpoint prevents two distinct types of fork collapse. Unsupervised hierarchical clustering of protein abundance on nascent DNA is sufficient to identify protein complexes and place newly identified replisome-associated proteins into functional pathways. As an example, we demonstrate that ZNF644 complexes with the G9a/GLP methyltransferase at replication forks and is needed to prevent replication-associated DNA damage. Our data reveal how the replication checkpoint preserves genome integrity, provide insights into the mechanism of action of ATR inhibitors, and will be a useful resource for replication, DNA repair, and chromatin investigators. PMID:26365379

  7. Blocking CHK1 Expression Induces Apoptosis and Abrogates the G2 Checkpoint Mechanism

    Directory of Open Access Journals (Sweden)

    Yan Luo

    2001-01-01

    Full Text Available Checkpoint kinase 1 (Chki is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates the Cdc2 activating phosphatase Cdc25C. This in turn inactivates Cdc2, which leads to G2/M arrest. We report that blocking Chki expression by antisense or ribozymes in mammalian cells induces apoptosis and interferes with the G2/M arrest induced by adriamycin. The Chki inhibitor UCN-01 also blocks the G2 arrest after DNA damage and renders cells more susceptible to adriamycin. These results indicate that Chki is an essential gene for the checkpoint mechanism during normal cell proliferation as well as in the DNA damage response.

  8. Hierarchical Non-blocking Coordinated Checkpointing Algorithms for Mobile Distributed Computing

    Directory of Open Access Journals (Sweden)

    Parveen Kumar

    2010-01-01

    Full Text Available Mobile system typically uses wireless communication which is based on electromagnetic waves and utilizes a shared broadcast medium. This has made possible creating a mobile distributed computing environment and has brought us several new challenges in distributed protocol design. So many issues such as range of transmission, limited power supply due to battery capacity and mobility of processes. These new issue makes traditional recovery algorithm unsuitable. In this paper, we propose hierarchical non blocking coordinated checkpointing algorithms suitable for mobile distributed computing. The algorithm is non-blocking, requires minimum message logging, has minimum stable storage requirement and produce a consistent set of checkpoints. This algorithm requires minimum number of processes to take checkpoint.

  9. Combining targeted therapy and immune checkpoint inhibitors in the treatment of metastatic melanoma

    Institute of Scientific and Technical Information of China (English)

    Teresa Kim; Rodabe N Amaria; Christine Spencer; Alexandre Reuben; Zachary A Cooper; Jennifer A Wargo

    2014-01-01

    Melanoma is the deadliest form of skin cancer and has an incidence that is rising faster than any other solid tumor. Metastatic melanoma treatment has considerably progressed in the past ifve years with the introduction of targeted therapy (BARF and MEK inhibitors) and immune checkpoint blockade (anti-CTLA4, anti-PD-1, and anti-PD-L1). However, each treatment modality has limitations. Treatment with targeted therapy has been associated with a high response rate, but with short-term responses. Conversely, treatment with immune checkpoint blockade has a lower response rate, but with long-term responses. Targeted therapy affects antitumor immunity, and synergy may exist when targeted therapy is combined with immunotherapy. hTis article presents a brief review of the rationale and evidence for the potential synergy between targeted therapy and immune checkpoint blockade. Challenges and directions for future studies are also proposed.

  10. Use of checkpoint-restart for complex HEP software on traditional architectures and Intel MIC

    International Nuclear Information System (INIS)

    Process checkpoint-restart is a technology with great potential for use in HEP workflows. Use cases include debugging, reducing the startup time of applications both in offline batch jobs and the High Level Trigger, permitting job preemption in environments where spare CPU cycles are being used opportunistically and efficient scheduling of a mix of multicore and single-threaded jobs. We report on tests of checkpoint-restart technology using CMS software, Geant4-MT (multi-threaded Geant4), and the DMTCP (Distributed Multithreaded Checkpointing) package. We analyze both single- and multi-threaded applications and test on both standard Intel x86 architectures and on Intel MIC. The tests with multi-threaded applications on Intel MIC are used to consider scalability and performance. These are considered an indicator of what the future may hold for many-core computing

  11. RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast

    International Nuclear Information System (INIS)

    Highlights: ► RNAi is linked to the cell cycle checkpoint in fission yeast. ► Ptr1 co-purifies with Ago1. ► The ptr1-1 mutation impairs the checkpoint but does not affect gene silencing. ► ago1+ and ptr1+ regulate the cell cycle checkpoint via the same pathway. ► Mutations in ago1+ and ptr1+ lead to the nuclear accumulation of poly(A)+ RNAs. -- Abstract: Ago1, an effector protein of RNA interference (RNAi), regulates heterochromatin silencing and cell cycle arrest in fission yeast. However, the mechanism by which Ago1 controls cell cycle checkpoint following hydroxyurea (HU) treatment has not been elucidated. In this study, we show that Ago1 and other RNAi factors control cell cycle checkpoint following HU treatment via a mechanism independent of silencing. While silencing requires dcr1+, the overexpression of ago1+ alleviated the cell cycle defect in dcr1Δ. Ago1 interacted with the mRNA export factor, Ptr1. The ptr1-1 mutation impaired cell cycle checkpoint but gene silencing was unaffected. Genetic analysis revealed that the regulation of cell cycle checkpoint by ago1+ is dependent on ptr1+. Nuclear accumulation of poly(A)+ RNAs was detected in mutants of ago1+ and ptr1+, suggesting there is a functional link between the cell cycle checkpoint and RNAi-mediated RNA quality control.

  12. The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

    International Nuclear Information System (INIS)

    Inhibition of DNA replication and physical DNA damage induce checkpoint responses that arrest cell cycle progression at two different stages. In Saccharomyces cerevisiae, the execution of both checkpoint responses requires the Mec1 and Rad53 proteins. This observation led to the suggestion that these checkpoint responses are mediated through a common signal transduction pathway. However, because the checkpoint-induced arrests occur at different cell cycle stages, the downstream effectors mediating these arrests are likely to be distinct. We have previously shown that the S. cerevisiae protein Pds1p is an anaphase inhibitor and is essential for cell cycle arrest in mitosis in the presence DNA damage. Herein we show that DNA damage, but not inhibition of DNA replication, induces the phosphorylation of Pds1p. Analyses of Pds1p phosphorylation in different checkpoint mutants reveal that in the presence of DNA damage, Pds1p is phosphorylated in a Mec1p- and Rad9p-dependent hut Rad53p-independent manner. Our data place Pds1p and Rad53p on parallel branches of the DNA damage checkpoint pathway. We suggest that Pds1p is a downstream target of the DNA damage checkpoint pathway and that it is involved in implementing the DNA damage checkpoint arrest specifically in mitosis

  13. Individualist America and Today's Immigrants.

    Science.gov (United States)

    Skerry, Peter

    1991-01-01

    Reviews James Fallows's "More Like Us: Making America Great Again," a book conceived while he resided in Japan. Fallows stresses the virtues of individualism and competition. He advocates workfare, education vouchers, and generous immigration levels. He pays little attention, however, to the institutions that nurture and temper individualism. (DM)

  14. Immigration, social cohesion, and naturalization

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2010-01-01

    The standard appeal to social cohesion in relation to immigration concerns admittance and residence. But social cohesion is sometimes also invoked as a relevant concern in relation to the attainment of citizenship in the state through naturalization. Many western states have recently tightened...

  15. Immigration Facts on Foreign Students

    Science.gov (United States)

    Ruiz, Neil G.

    2013-01-01

    U.S. policymakers have put forth various immigration reform proposals to improve retention of foreign students obtaining advanced degrees in science, technology, engineering, and mathematics (STEM) from American universities. These students are considered particularly desirable because they, like their American counterparts, offer the types of…

  16. Banking unbanked immigrants through remittances

    OpenAIRE

    George Samuels

    2003-01-01

    High service fees for sending money abroad can be a financial strain for low and moderate-income immigrants. George Samuels explores how some mainstream financial institutions are offering competitive pricing for the service and, as a result, are banking a new set of customers.

  17. Functions of spindle check-point and its relationship to chromosome instability

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    It is generally believed that the equal distribution of genetic materials to two daughter cells during mitosis is the key to cell health and development. During the dynamic process, spindle checkpoint plays a very important role in chromosome movements and final sister chromatid separation. The equal and precise segregation of chromosomes contributes to the genomic stability while aberrant separations result in chromosome instability that causes pathogenesis of certain diseases such as Down's syndrome and cancers. Kinetochore and its regulatory proteins consist of the spindle checkpoint and determine the spatial and temporal orders of chromosome segregation.

  18. Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints

    DEFF Research Database (Denmark)

    Jahn, Stephan C; Corsino, Patrick E; Davis, Bradley J;

    2013-01-01

    The cell has many mechanisms for protecting the integrity of its genome. These mechanisms are often weakened or absent in many cancers, leading to high rates of chromosomal instability in tumors. Control of the cell cycle is crucial for the function of these checkpoints, and is frequently lost in...... instability. Expression of these complexes in the MCF10A cell line leads to retinoblastoma protein (Rb) hyperphosphorylation, a subsequent increase in proliferation rate, and increased expression of the spindle assembly checkpoint protein Mad2. This results in a strengthening of the spindle assembly...

  19. Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts

    OpenAIRE

    Kumar, Sanjay; Yoo, Hae Yong; Kumagai, Akiko; Shevchenko, Anna; Shevchenko, Andrej; Dunphy, William G.

    2012-01-01

    TopBP1 is critical for both DNA replication and checkpoint regulation in vertebrate cells. In this study, we have identified Rif1 as a binding partner of TopBP1 in Xenopus egg extracts. In addition, Rif1 also interacts with both ATM and the Mre11-Rad50-Nbs1 (MRN) complex, which are key regulators of checkpoint responses to double-stranded DNA breaks (DSBs). Depletion of Rif1 from egg extracts compromises the activation of Chk1 in response to DSBs but not stalled replication forks. Removal of ...

  20. Immigration and trade creation for the US: The role of immigrant occupation

    OpenAIRE

    Mundra, Kusum

    2012-01-01

    This paper highlights that the immigrants' effect on trade is not identical across all types of immigrants but it varies with the immigrants' occupation. Using a sample of 63 U.S. trading partners which are also big immigrant sending countries over the years 1991-2000, this paper finds that the immigrant trade elasticity for the no occupation group is similar in magnitude to the immigrant effect on trade estimated in the literature. However, this does not capture the full extent of the effect...

  1. Immigration and Trade Creation for the U.S.: The Role of Immigrant Occupation

    OpenAIRE

    Mundra, Kusum

    2012-01-01

    This paper highlights that the immigrants' effect on trade is not identical across all types of immigrants but it varies with the immigrants' occupation. Using a sample of 63 U.S. trading partners which are also big immigrant sending countries over the years 1991-2000, this paper finds that the immigrant trade elasticity for the no occupation group is similar in magnitude to the immigrant effect on trade estimated in the literature. However, this does not capture the full extent of the effect...

  2. Immigration and Trade Creation for the U.S.: Role of Immigrant Occupation

    OpenAIRE

    Kusum Mundra

    2012-01-01

    This paper highlights that the immigrants' effect on trade is not identical across all types of immigrants but it varies with the immigrants' occupation. Using a sample of 63 U.S. trading partners which are also big immigrant sending countries over the years 1991 - 2000 this paper finds that the immigrant trade elasticity for the no occupation group is similar in magnitude to the immigrant effect on trade estimated in the literature. However, this does not capture the full extent of the effec...

  3. Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation.

    Science.gov (United States)

    Johmura, Yoshikazu; Yamashita, Emiri; Shimada, Midori; Nakanishi, Keiko; Nakanishi, Makoto

    2016-01-01

    Susceptibility to senescence caused by defective DNA repair is a major hallmark of progeroid syndrome patients, but molecular mechanisms of how defective DNA repair predisposes to senescence are largely unknown. We demonstrate here that suppression of DNA repair pathways extends the duration of Chk1-dependent G2 checkpoint activation and sensitizes cells to senescence through enhancement of mitosis skipping. Extension of G2 checkpoint activation by introduction of the TopBP1 activation domain and the nondegradable mutant of Claspin sensitizes cells to senescence. In contrast, a shortening of G2 checkpoint activation by expression of SIRT6 or depletion of OTUB2 reduces susceptibility to senescence. Fibroblasts from progeroid syndromes tested shows a correlation between an extension of G2 checkpoint activation and an increase in the susceptibility to senescence. These results suggest that extension of G2 checkpoint activation caused by defective DNA repair is critical for senescence predisposition in progeroid syndrome patients. PMID:27507734

  4. Dialogue on Immigration: Should the Golden Door be Closed?

    Science.gov (United States)

    Durfee, David, Ed.

    1983-01-01

    Papers presented by panelists at the Mid-Atlantic Regional Conference for the Social Studies are reprinted. Titles are: "Why the Focus on Immigration,""The Historical Process of Immigration,""Major Areas of Immigration Concern,""Human Implications of Immigration Law and Policies,""Refugee vs. Immigrant," and "How Educational Agencies Serve…

  5. Immigrant health: legal tools/legal barriers.

    Science.gov (United States)

    Moua, Mee; Guerra, Fernando A; Moore, Jill D; Valdiserri, Ronald O

    2002-01-01

    The United States is a country of immigrants, our government having been formed by recent arrivals. This trend has continued throughout our history; according to the Center for Immigration Studies, more than 26 million immigrants have settled in the United States since 1970, and approximately one million new immigrants come to the United States each year. The immigrant population faces highly diverse health issues that states, cities, and counties must address, many of which pose significant legal and policy issues. Social, cultural, and linguistic factors complicate those challenges, as does the overlay of federal immigration and health policy. Two federal laws, the Welfare Reform Act of 1996 and Title VI of the federal Civil Rights Act of 1964, have affected immigrants in two very different ways. The former made it difficult for immigrants to qualify for publicly funded benefits. In contrast, Title VI made it easier for immigrants to obtain benefits by requiring federally funded service providers to offer translating services to persons with limited English language skills. Tuberculosis treatment is perhaps the most pressing health need among recent arrivals to the United States. Methods to slow down and hopefully eliminate this disease are underway, but a more comprehensive approach to not only tuberculosis but to immigrant health in general is needed. Indeed, it will benefit those directly affected by tuberculosis and will have serious implications for the entire population for generations to come. PMID:12508525

  6. Cells bearing chromosome aberrations lacking one telomere are selectively blocked at the G2/M checkpoint

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, Pilar [Unitat de Biologia Cel.lular, Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Barquinero, Joan Francesc [Unitat d' Antropologia Biologica, Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Duran, Assumpta [Unitat de Biologia Cel.lular, Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Caballin, Maria Rosa [Unitat d' Antropologia Biologica, Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain); Ribas, Montserrat [Servei de Radiofisica i Radioproteccio de l' Hospital de la Santa Creu i Sant Pau, 08025 Barcelona (Spain); Barrios, Leonardo, E-mail: Lleonard.Barrios@uab.cat [Unitat de Biologia Cel.lular, Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Bellaterra (Spain)

    2009-11-02

    Cell cycle checkpoints are part of the cellular mechanisms to maintain genomic integrity. After ionizing radiation exposure, the cells can show delay or arrest in their progression through the cell cycle, as well as an activation of the DNA repair machinery in order to reduce the damage. The G2/M checkpoint prevents G2 cells entering mitosis until the DNA damage has been reduced. The present study evaluates which G0 radiation-induced chromosome aberrations are negatively selected in the G2/M checkpoint. For this purpose, peripheral blood samples were irradiated at 1 and 3 Gy of {gamma}-rays, and lymphocytes were cultured for 48 h. Calyculin-A and Colcemid were used to analyze, in the same slide, cells in G2 and M. Chromosome spreads were consecutively analyzed by solid stain, pancentromeric and pantelomeric FISH and mFISH. The results show that the frequency of incomplete chromosome elements, those lacking a telomeric signal at one end, decreases abruptly from G2 to M. This indicates that cells with incomplete chromosome elements can progress from G0 to G2, but at the G2/M checkpoint suffer a strong negative selection.

  7. Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway

    International Nuclear Information System (INIS)

    When exposed to DNA-damaging insults such as ionizing radiation (IR) or ultraviolet light (UV), mammalian cells activate checkpoint pathways to halt cell cycle progression or induce cell death. Here we examined the ability of five commonly used anticancer drugs with different mechanisms of action to activate the Chk1/Chk2-Cdc25A-CDK2/cyclin E cell cycle checkpoint pathway, previously shown to be induced by IR or UV. Whereas exposure of human cells to topoisomerase inhibitors camptothecin, etoposide, or adriamycin resulted in rapid (within 1 h) activation of the pathway including degradation of the Cdc25A phosphatase and inhibition of cyclin E/CDK2 kinase activity, taxol failed to activate this checkpoint even after a prolonged treatment. Unexpectedly, although the alkylating agent cisplatin also induced degradation of Cdc25A (albeit delayed, after 8-12 h), cyclin E/CDK2 activity was elevated and DNA synthesis continued, a phenomena that correlated with increased E2F1 protein levels and consequently enhanced expression of cyclin E. These results reveal a differential impact of various classes of anticancer chemotherapeutics on the Cdc25A-degradation pathway, and indicate that the kinetics of checkpoint induction, and the relative balance of key components within the DNA damage response network may dictate whether the treated cells arrest their cell cycle progression

  8. A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

    DEFF Research Database (Denmark)

    Blasius, Melanie; Forment, Josep V; Thakkar, Neha;

    2011-01-01

    BACKGROUND: The cell-cycle checkpoint kinase Chk1 is essential in mammalian cells due to its roles in controlling processes such as DNA replication, mitosis and DNA-damage responses. Despite its paramount importance, how Chk1 controls these functions remains unclear, mainly because very few Chk1...

  9. Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

    Institute of Scientific and Technical Information of China (English)

    Hai Jiang; Jianchun Wu; Chen He; Wending Yang; Honglin Li

    2009-01-01

    Cyclin-dependent kinase 1 (Cdk1)/cyclin B1 complex is the driving force for mitotic entry, and its activation is tightly regulated by the G2/M checkpoint. We originally reported that a novel protein C53 (also known as Cdk5rap3 and LZAP) potentiates DNA damage-induced cell death by modulating the G2/M checkpoint. More recently, Wang et al. (2007) found that C53/LZAP may function as a tumor suppressor by way of inhibiting NF-kB signaling. We report here the identification of C53 protein as a novel regulator of Cdk1 activation. We found that knockdown of C53 protein causes delayed Cdkl activation and mitotic entry. During DNA damage response, activation of checkpoint kinase 1 and 2 (Chk1 and Chk2) is partially inhibited by C53 overexpression. Intriguingly, we found that C53 interacts with Chkl and antagonizes its function. Moreover, a portion of C53 protein is localized at the centrosome, and centrosome-targeting C53 potently promotes local Cdk1 activation. Taken together, our results strongly suggest that C53 is a novel negative regulator of checkpoint response. By counteracting Chk1, C53 promotes Cdk1 activation and mitotic entry in both unperturbed cell-cycle progression and DNA damage response.

  10. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

    DEFF Research Database (Denmark)

    McGranahan, Nicholas; Furness, Andrew J S; Rosenthal, Rachel;

    2016-01-01

    As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of neoantigen intratumor heterogeneity (ITH) on antitumor immunity. Through integrated analysis of ITH and neoantigen burden, we...

  11. The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor

    Science.gov (United States)

    Ivanova, Tsvetomira; Alves-Rodrigues, Isabel; Gómez-Escoda, Blanca; Dutta, Chaitali; DeCaprio, James A.; Rhind, Nick; Hidalgo, Elena; Ayté, José

    2013-01-01

    In fission yeast cells, Cds1 is the effector kinase of the DNA replication checkpoint. We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1 is phosphorylated and inactivated by Cds1, resulting in activation of MluI-binding factor (MBF)–dependent transcription. This is essential to reinitiate DNA synthesis and for correct G1-to-S transition. Here we show that Cdc10, which is an essential part of the MBF core, is the target of the DNA damage checkpoint. When fission yeast cells are treated with DNA-damaging agents, Chk1 is activated and phosphorylates Cdc10 at its carboxy-terminal domain. This modification is responsible for the repression of MBF-dependent transcription through induced release of MBF from chromatin. This inactivation of MBF is important for survival of cells challenged with DNA-damaging agents. Thus Yox1 and Cdc10 couple normal cell cycle regulation in unperturbed conditions and the DNA replication and DNA damage checkpoints into a single transcriptional complex. PMID:24006488

  12. The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.

    Science.gov (United States)

    Ivanova, Tsvetomira; Alves-Rodrigues, Isabel; Gómez-Escoda, Blanca; Dutta, Chaitali; DeCaprio, James A; Rhind, Nick; Hidalgo, Elena; Ayté, José

    2013-11-01

    In fission yeast cells, Cds1 is the effector kinase of the DNA replication checkpoint. We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1 is phosphorylated and inactivated by Cds1, resulting in activation of MluI-binding factor (MBF)-dependent transcription. This is essential to reinitiate DNA synthesis and for correct G1-to-S transition. Here we show that Cdc10, which is an essential part of the MBF core, is the target of the DNA damage checkpoint. When fission yeast cells are treated with DNA-damaging agents, Chk1 is activated and phosphorylates Cdc10 at its carboxy-terminal domain. This modification is responsible for the repression of MBF-dependent transcription through induced release of MBF from chromatin. This inactivation of MBF is important for survival of cells challenged with DNA-damaging agents. Thus Yox1 and Cdc10 couple normal cell cycle regulation in unperturbed conditions and the DNA replication and DNA damage checkpoints into a single transcriptional complex. PMID:24006488

  13. Synthesis of Fault-Tolerant Embedded Systems with Checkpointing and Replication

    DEFF Research Database (Denmark)

    Izosimov, Viacheslav; Pop, Paul; Eles, Petru; Peng, Zebo

    We present an approach to the synthesis of fault-tolerant hard real-time systems for safety-critical applications. We use checkpointing with rollback recovery and active replication for tolerating transient faults. Processes are statically scheduled and communications are performed using the time...

  14. Cells bearing chromosome aberrations lacking one telomere are selectively blocked at the G2/M checkpoint

    International Nuclear Information System (INIS)

    Cell cycle checkpoints are part of the cellular mechanisms to maintain genomic integrity. After ionizing radiation exposure, the cells can show delay or arrest in their progression through the cell cycle, as well as an activation of the DNA repair machinery in order to reduce the damage. The G2/M checkpoint prevents G2 cells entering mitosis until the DNA damage has been reduced. The present study evaluates which G0 radiation-induced chromosome aberrations are negatively selected in the G2/M checkpoint. For this purpose, peripheral blood samples were irradiated at 1 and 3 Gy of γ-rays, and lymphocytes were cultured for 48 h. Calyculin-A and Colcemid were used to analyze, in the same slide, cells in G2 and M. Chromosome spreads were consecutively analyzed by solid stain, pancentromeric and pantelomeric FISH and mFISH. The results show that the frequency of incomplete chromosome elements, those lacking a telomeric signal at one end, decreases abruptly from G2 to M. This indicates that cells with incomplete chromosome elements can progress from G0 to G2, but at the G2/M checkpoint suffer a strong negative selection.

  15. Importance of immunopharmacogenomics in cancer treatment: Patient selection and monitoring for immune checkpoint antibodies.

    Science.gov (United States)

    Choudhury, Noura; Nakamura, Yusuke

    2016-02-01

    In the last 5 years, immune checkpoint antibodies have become established as anticancer agents for various types of cancer. These antibody drugs, namely cytotoxic T-lymphocyte-associated antigen, programmed death-1, and programmed death ligand-1 antibodies, have revealed relatively high response rates, the ability to induce durable responses, and clinical efficacy in malignancies not previously thought to be susceptible to immune-based strategies. However, because of its unique mechanisms of activating the host immune system against cancer as well as expensive cost, immune checkpoint blockade faces novel challenges in selecting appropriate patient populations, monitoring clinical responses, and predicting immune adverse events. The development of objective criteria for selecting patient populations that are likely to have benefit from these therapies has been vigorously investigated but still remains unclear. In this review, we describe immune checkpoint inhibition-specific challenges with patient selection and monitoring, and focus on approaches to remedy these challenges. We also discuss applications of the emerging field of immunopharmacogenomics for guiding selection and monitoring for anti-immune checkpoint treatment. PMID:26678880

  16. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes

    Energy Technology Data Exchange (ETDEWEB)

    Bhatt, Shweta; Gupta, Manoj; Khamaisi, Mogher; Martinez, Rachael; Gritsenko, Marina A.; Wagner, Bridget; Guye, Patrick; Busskamp, Volker; Shirakawa, Jun; Wu, Gongxiong; Liew, Chong Wee; Clauss, Therese RW; Valdez, Ivan; EL Ouaaman, Abdelfattah; Dirice, Ercument; Takatani, Tomozumi; Keenan, Hillary; Smith, Richard D.; Church, George; Weiss, Ron; Wagers, Amy J.; Qian, Weijun; King, George L.; Kulkami, Rohit N.

    2015-08-04

    Themechanisms underlying the development of complications in type 1 diabetes (T1D) are poorly understood. Disease modeling of induced pluripotent stem cells (iPSCs) from patients with longstanding T1D(disease durationR50 years) with severe (Medalist +C) or absent to mild complications (Medalist *C) revealed impaired growth, reprogramming, and differentiation in Medalist +C. Genomics and proteomics analyses suggested differential regulation of DNA damage checkpoint proteins favoring protection from cellular apoptosis in Medalist *C. In silico analyses showed altered expression patterns of DNA damage checkpoint factors among the Medalist groups to be targets of miR200, whose expression was significantly elevated in Medalist +C serum. Notably, neurons differentiated from Medalist +C iPSCs exhibited enhanced susceptibility to genotoxic stress that worsened upon miR200 overexpression. Furthermore, knockdown of miR200 in Medalist +C fibroblasts and iPSCs rescued checkpoint protein expression and reduced DNA damage.WeproposemiR200-regulated DNA damage checkpoint pathway as a potential therapeutic target for treating complications of diabetes.

  17. The effect of heavy ion on DNA damage checkpoint, and the discovery of its sensitizing compounds

    International Nuclear Information System (INIS)

    In the present study, we demonstrated that a persimmon leaf extract (PLE) promoted cytotoxic effect of cancer cells by chemotherapeutic agents inhibiting the DNA checkpoint activity. Therefore, PLE is a strong possibility of sensitizing agents for heavy ion cancer therapy. Herein, we investigate the mechanism of cellular responses to DNA damage induced by heavy ion radiation with PLE. Human adenocarcinoma A549 cells were pre-incubated with PLE (0, 1, 10, 30 μg/mL) at one hour. After pre-incubation, the cells were irradiated with carbon-ion beams [135C (linear energy transfer (LET) 70 Kev/um)]. The phosphorylation of p53, Chk1 and SMC1 was increased by 2.5 Gy heavy ion exposure. PLE decreased the phosphorylation of p53, Chk1 and SMC1 in cells damaged by heavy ion with PLE dose-dependent manner. G2/M checkpoint was investigated in percentage of mitotic cell. The percentage of mitotic cell decreased in heavy ion beam treatment. Interestingly, heavy ion with PLE treatment was significantly increased. The result indicated that PLE treatment disrupted the G2/M checkpoint activated by heavy ion. These results indicated that DNA damage checkpoint system in heavy ion exposed cells were abrogated by PLE treatment through the inhibition of ataxia telangiectasia mutated (ATM) and/or AT and Rad3 related (ATR)-dependent signaling pathway. (author)

  18. Restrictive Immigration Policies and Latino Immigrant Identity in the United States

    OpenAIRE

    Massey, Douglas; Sánchez R., Magaly

    2009-01-01

    The United States is presently characterized by rising anti-immigrant sentiment, repressive immigration enforcement, and the negative framing of Latinos as threatening and undesirable. As a result, social boundaries between immigrants and natives have hardened and boundary crossing has become more difficult. Under these circumstances, the prediction of classical assimilation theory is turned on its head: the more time that immigrants spend in the United States and the more contact they have w...

  19. Intimate partner violence against women and its related immigration stressors in Pakistani immigrant families in Germany

    OpenAIRE

    Zakar, Rubeena; Zakar, Muhammad Zakria; Faist, Thomas; Krämer, Alexander

    2012-01-01

    This paper addresses the issue of intimate partner violence against women and its related immigration stressors in Pakistani immigrant families in Germany. Drawing on 32 in-depth interviews with Pakistani women in three cities in Germany, we found that psychological violence was the commonly reported violence among the study participants. The data showed that the process of immigration exacerbated tensions between spouses because of various immigration stressors such as threats to cultural id...

  20. A Comparison of Adjustment to University between Immigrant and Non-Immigrant Students

    OpenAIRE

    Chitnev, Veta

    2014-01-01

    Due to large immigrant student numbers enrolled in post-secondary education in Canada, adjustment of immigrant youth to mainstream culture at the university level is an important issue for Canadian educators. However, research on immigrant students’ adjustment while attending Canadian educational institutions is scarce. The purpose of the present thesis was to address this gap by examining Canadian immigrant students’ adjustment to university and to identify potential protective factors that...

  1. Effects of Immigrant Legalization on Crime: The 1986 Immigration Reform and Control Act

    OpenAIRE

    Scott Baker

    2013-01-01

    In the late 1970's, rates of undocumented immigration into the United States increased dra- matically. This increase led to pressure on the federal government to nd some way of dealing with the immigrants, culminating in the 1986 Immigration Reform and Control Act (IRCA). This paper seeks to examine the e ects that the 1986 IRCA, which legalized over 2.5 million undocumented immigrants, had on the commission of crime in the United States. Using ad- ministrative data from the IRCA application ...

  2. Age at immigration and crime. Findings for male immigrants in Norway

    OpenAIRE

    Synøve Nygaard Andersen; Torbjørn Skardhamar

    2012-01-01

    Previous studies have identified an "immigrant paradox" in crime in which crime rates are highest among immigrants who are young when they arrive in the host country, even though social capital and integration in the labour market and social networks favour the young. We use Norwegian registry data to estimate the probability of committing at least one crime in any year after the year of immigration, and we include interaction terms between age and age at immigration to explore the troublesom...

  3. The Effect of Immigrant Selection and the IT Bust on the Entry Earnings of Immigrants

    OpenAIRE

    Hou, Feng; Picot, Garnett

    2009-01-01

    Immigrant selection rules were altered in the early 1990s, resulting in a dramatic increase in the share of entering immigrants with a university degree and in the skilled economic class. These changes were very successfully implemented following significant deterioration in entry earnings during the 1980s. This paper asks whether these change in immigrant selection contributed positively to immigrant entry earnings during the 1990s. Moving to the 2000s, the paper asks whether, after almost t...

  4. Why are immigrants' incarceration rates so low?: Evidence on selective immigration, deterrence, and deportation

    OpenAIRE

    Kristin F. Butcher; Piehl, Anne Morrison

    2006-01-01

    Immigrants to the United States tend to have characteristics in common with native-born populations that are disproportionately incarcerated. The perception that immigration adversely affects crime rates led to legislation in the 1990s that particularly increased punishment of criminal aliens. In fact, immigrants have much lower institutionalization (incarceration) rates than the native born—on the order of one-fifth the rate of natives. More recently arrived immigrants have the lowest relati...

  5. The Two-Step Australian Immigration Policy and its Impact on Immigrant Employment Outcomes

    OpenAIRE

    Gregory, Robert G.

    2014-01-01

    Three decades ago most immigrants to Australia with work entitlements came as permanent settlers. Today the annual allocation of temporary visas, with work entitlements, outnumbers permanent settler visas by a ratio of three to one. The new environment, with so many temporary visa holders, has led to a two-step immigration policy whereby an increasing proportion of immigrants come first as a temporary immigrant, to work or study, and then seek to move to permanent status. Around one half of p...

  6. Healthcare system information at language schools for newly arrived immigrants

    DEFF Research Database (Denmark)

    Tynell, Lena Lyngholt; Wimmelmann, Camilla Lawaetz; Jervelund, Signe Smith

    2016-01-01

    Objective: In most European countries, immigrants do not systematically learn about the host countries’ healthcare system when arriving. This study investigated how newly arrived immigrants perceived the information they received about the Danish healthcare system. Method: Immigrants attending a ...

  7. Forecasting the Integration of Immigrants

    CERN Document Server

    Contucci, Pierluigi; Seyedi, Seyedalireza

    2015-01-01

    This paper presents a quantitative framework for forecasting immigrant integration using immigrant density as the single driver. By comparing forecasted integration estimates based on data collected up to specific periods in time, with observed integration quantities beyond the specified period, we show that: Our forecasts are prompt-readily available after a short period of time, accurate-with a small relative error-and finally robust-able to predict integration correctly for several years to come. The research reported here proves that the proposed model of integration and its forecast framework are simple and effective tools to reduce uncertainties about how integration phenomena emerge and how they are likely to develop in response to increased migration levels in the future.

  8. Educational Attainment: Analysis by Immigrant Generation

    OpenAIRE

    Chiswick, Barry R.; DebBurman, Noyna

    2003-01-01

    This paper presents a theoretical and empirical analysis of the largely ignored issue of the determinants of the educational attainment of adults by immigrant generation. Using Current Population Survey (CPS) data, differences in educational attainment are analyzed by immigrant generation (first, second, and higher order generations), and among the foreign born by country of birth and age at immigration. Second-generation American adults have the highest level of schooling, exceeding that of ...

  9. Immigrants' Language Skills: The Australian Experience

    OpenAIRE

    Barry R. Chiswick; Yew Liang Lee; Paul W. Miller

    2002-01-01

    This paper is concerned with the determinants of English language proficiency (speaking, reading and writing) among immigrants. It presents a model of immigrant destination language acquisition based on economic incentives, exposure to the destination language, and efficiency in second language acquisition. A unique data set, the Longitudinal Survey of Immigrants to Australia, is used to test the model. This survey had three waves, at about 6 months, 18 months and 3 1/2 years after immigratio...

  10. The Immigrant Wage Gap in Germany

    OpenAIRE

    Thomsen, Stephan L.; Gernandt, Johannes; Aldashev, Alisher

    2008-01-01

    Immigrants consist of foreigners and citizens with migration background. We analyze the wage gap between natives and these two groups in Germany. The estimates show a substantial gap for both groups with respect to natives. Discarding immigrants who completed education abroad reduces much of the immigrants' wage gap. This implies educational attainment in Germany is an important component of economic integration and degrees obtained abroad are valued less.

  11. Do Interest Groups Affects US Immigration Policy?

    OpenAIRE

    Giovanni Facchini; Anna Maria Mayda; Prachi Mishra

    2008-01-01

    While anecdotal evidence suggests that interest groups play a key role in shaping immigration policy, there is no systematic empirical analysis of this issue. In this paper, we construct an industry-level dataset for the United States, by combining information on the number of temporary work visas with data on lobbying activity associated with immigration. We find robust evidence that both pro- and anti-immigration interest groups play a statistically significant and economically relevant rol...

  12. The labour market impact of immigration

    OpenAIRE

    Dustmann, C.; Glitz, A.; Frattini, T.

    2008-01-01

    In the first part of this paper, we present a stylised model of the labour market impact of immigration. We then discuss mechanisms through which an economy can adjust to immigration: changes in factor prices, output mix and production technology. In the second part, we explain the problems of empirically estimating how immigration affects labour market outcomes of the resident population and review some strategies to address these. We then summarise some recent empirical studies for the UK a...

  13. Immigration and crime: an empirical analysis

    OpenAIRE

    Milo Bianchi; Paolo Buonanno; Paolo Pinotti

    2008-01-01

    In this paper we examine the empirical relationship between immigration and crime across Italian provinces during the period 1990-2003. Drawing on police data, we first document that the size of the immigrant population is positively correlated with the incidence of property crimes and with the overall crime rate. We then use instrumental variables based on migration towards other European countries to identify the causal impact of exogenous changes in the immigrant population of Italy. Accor...

  14. Does immigration cause crime? : evidence from Spain

    OpenAIRE

    Alonso-Borrego, César; Garoupa, Nuno; Vázquez, Pablo

    2011-01-01

    The relationship between crime and immigration has been a matter of controversy in the US and around the world. This paper investigates empirically the case of Spain. From 1999 to 2009, Spain has had a large wave of immigration from different areas of the globe. At the same time, crime rates have increased. However, by comparison with other European countries that have received similar massive immigration waves during the same period, crime rates in Spain have increased less considerably. We ...

  15. Immigration and Crime: Evidence from Canada

    OpenAIRE

    Zhang, Haimin

    2014-01-01

    There is growing belief in many developed countries, including Canada, that the large influx of the foreign-born population increases crime. Despite the heated public discussion, the immigrant-crime relationship is understudied in the literature. This paper identifies the causal linkages between immigration and crime using panel data constructed from the Uniform Crime Reporting Survey and the master files of the Census of Canada. This paper distinguishes immigrants by their years in Canada an...

  16. Understanding the Impact of Immigration on Crime

    OpenAIRE

    Spenkuch, Jörg L.

    2010-01-01

    Since the 1960s both crime rates and the share of immigrants among the American population have more than doubled. Almost three quarters of Americans believe immigration increases crime, yet existing academic research has shown no such effect. Using panel data on US counties from 1980 to 2000, this paper presents empirical evidence on a systematic and economically meaningful impact of immigration on crime. Consistent with the economic model of crime this effect is strongest for crimes motivat...

  17. Immigration Policy and Macroeconomic Performance in France

    OpenAIRE

    Boubtane, Ekrame; Coulibaly, Dramane; D'Albis, Hippolyte

    2015-01-01

    This paper quantitatively assesses the interaction between permanent immigration intoFrance and France's macroeconomic performance as seen through its GDP per capita and itsunemployment rate. It takes advantage of a new database where immigration is measuredby the flow of newly- issued long-term residence permits, categorized by both thenationality of the immigrant and the reason of permit issuance. Using a VAR modelestimation of monthly data over the period 1994-2008, we find that immigratio...

  18. Immigrants Responsiveness to Labor Market Conditions

    OpenAIRE

    Amuedo Dorantes, Catalina; De la Rica Goiricelaya, Sara

    2005-01-01

    Using data from the Spanish Labor Force Survey (Encuesta de Población Activa) from 1999 through 2004, we explore the role of regional employment opportunities in explaining the increasing immigrant flows of recent years despite the limited internal mobility on the part of natives. Subsequently, we investigate the policy question of whether immigration has helped reduced unemployment rate disparities across Spanish regions by attracting immigrant flows to regions offering better employment opp...

  19. Immigration Policy and Macroeconomic Performance in France

    OpenAIRE

    Hippolyte d’Albis; Ekrame Boubtane; Dramane Coulibaly

    2015-01-01

    This paper quantitatively assesses the interaction between permanent immigration into France and France's macroeconomic performance as seen through its GDP per capita and its unemployment rate. It takes advantage of a new database where immigration is measured by the ow of newly-issued long-term residence permits, categorized by both the nationality of the immigrant and the reason of permit issuance. Using a VAR model estimation of monthly data over the period 1994-2008, we find that immigrat...

  20. Immigration Policy and Macroeconomic Performance in France

    OpenAIRE

    Boubtane, Ekrame; Coulibaly, Dramane; Hippolyte D'Albis

    2015-01-01

    This paper quantitatively assesses the interaction between permanent immigration into France and France's macroeconomic performance as seen through its GDP per capita and its unemployment rate. It takes advantage of a new database where immigration is measured by the flow of newly- issued long-term residence permits, categorized by both the nationality of the immigrant and the reason of permit issuance. Using a VAR model estimation of monthly data over the period 1994-2008, we find that immig...

  1. Active inclusion of immigrants in Poland

    OpenAIRE

    Duszczyk, Maciej; Góra, Marek

    2012-01-01

    Poland has traditionally been treated as an emigration country. Since recently Poland has been changing into an emigration-immigration country. The latter, namely immigration, was boosted by the European Union membership and by stable and strong growth of the country. In the last years, immigrants have started to play an important role in the Polish labour market, which creates an additional challenge for the institutional structure. At the same time the institutional framework for receiving ...

  2. What drives the language proficiency of immigrants?

    OpenAIRE

    Isphording, Ingo E.

    2015-01-01

    Language proficiency is a key driver of immigrant integration. It increases job opportunities and facilitates social and political participation. However, despite its vital importance, many immigrants never reach adequate proficiency in the host country language. Therefore, insights into the underlying processes and associated factors are crucial for designing measures to improve language acquisition. Empirical evidence shows that immigrants differ in their ability to learn languages, in thei...

  3. Terrorism and integration of Muslim immigrants

    OpenAIRE

    Elsayed, A.E.A.; Grip, A. de

    2013-01-01

    We study the effect that a series of fundamentalist-Islamic terrorist attacks in Europe had on the attitudes of Muslim immigrants in the Netherlands towards integration. Shortly after the attacks, Muslim immigrants' perceived integration, as measured by various indicators, decreased significantly relative to that of non-Muslims immigrants whereas there is no evidence for the existence of a negative trend in the integration of Muslims prior to the terrorist attacks. We further show that terror...

  4. Cardiovascular diseases in immigrants in Sweden

    OpenAIRE

    Gadd, Malin

    2006-01-01

    Aims The general aim with this project was to elucidate coronary heart disease (CHD) morbidity and mortality among immigrants in Sweden, by investigating the morbidity from CHD, comparing all-cause and CHD mortality between immigrants in Sweden and natives in the country of birth, analyzing the trend of CHD, and estimating the prevalence of CHD risk factors. Methods The first study was designed as a follow-up study of the incidence of CHD among twelve immigrant groups. T...

  5. Immigrant Assimilation, Trust and Social Capital

    OpenAIRE

    Cox, James C.; Orman, Wafa Hakim

    2010-01-01

    Trust is a crucial component of social capital. We use an experimental moonlighting game with a representative sample of the U.S. population, oversampling immigrants, to study trust, positive, and negative reciprocity between first-generation immigrants and native-born Americans as a measure of immigrant assimilation. We also survey subjects in order to relate trusting and trustworthy behavior with demographic characteristics and traditional, survey-based measures of social capital. We find t...

  6. Immigrant Entrepreneurs in Israel, Canada and California

    OpenAIRE

    Razin, Eran

    1990-01-01

    Entrepreneurial activity has served as a route of economic advancement and social mobility for many of the more successful immigrant groups in their new host countries. In addition to varying ethnic resources, the formation of small-businesses by new immigrants depends greatly on characteristics of the host country and the specific urban area. Moreover, interaction of location and ethnicity factors may influence entrepreneurial behavior of immigrant groups; i.e. the role of location may diffe...

  7. Characteristics of immigrants and bilateral trade

    OpenAIRE

    José Vicente Blanes-Cristóbal

    2008-01-01

    This paper tests the impact of immigration on bilateral trade using Spanish data from 1995 to 2003. It also explores some possible mechanisms behind this link. It uses a gravity equation for trade augmented with an immigrant’s stock variable and a set of control variables. The immigrants variable enters the estimated equation in different ways depending on immigrant relevant characteristics both individual and non individualspecific. Results show that there is a positive link between immigrat...

  8. The heterogeneity in immigrants unhealthy assimilation

    OpenAIRE

    Barbieri, Paolo Nicola

    2016-01-01

    Immigrants upon their arrival in the United States are in better health condition with respect to their American counterpart however such advantage erodes over time. In this paper, we study the heterogeneity of such unhealthy behaviours assimilation among different arrival cohorts. We focus our analysis on binge drinking and cigarette consumption as a proxy for unhealthy behaviour assimilation by immigrants. Regarding binge drinking we show that more recent immigrant cohorts arriv...

  9. Interethnic Marriages and Economic Assimilation of Immigrants

    OpenAIRE

    Kantarevic, Jasmin

    2004-01-01

    This paper examines the relationship between interethnic marriages and economic assimilation among immigrants in the United States. Two competing hypotheses are evaluated: the productivity hypothesis, according to which immigrants married to native-born spouses assimilate faster than comparable immigrants married to foreign-born spouses because spouses play an integral role in the human capital accumulation of their partners; and the selection hypothesis, according to which the relationship b...

  10. The Acceleration of Immigrant Unhealthy Assimilation

    OpenAIRE

    Giuntella, Osea; Stella, Luca

    2016-01-01

    It is well-known that immigrants tend to be healthier than US natives and that this advantage erodes with time spent in the US. However, we know less about the heterogeneity of these trajectories among arrival cohorts. Recent studies have shown that later arrival cohorts of immigrants have lower entry wages and experience less economic assimilation. In this paper, we investigate whether similar cohort effects can be observed in the weight assimilation of immigrants in the US. Focusing on obes...

  11. Native Welfare Losses from High Skilled Immigration

    OpenAIRE

    Kemnitz, Alexander

    2007-01-01

    This paper explores the effects of high skilled immigration to a host country with unionized low skilled labor and an unemployment insurance scheme. We show that such immigration can create a negative immigration surplus due to adverse effects on low skilled employment, provided that fiscal redistribution is not too intense and the elasticity between high and low skilled labor is high as empirical evidence suggests.

  12. Determinants of Recent Immigrants' Location Choices

    DEFF Research Database (Denmark)

    Damm, Anna Piil

    This paper exploits a Danish spatial dispersal policy on refugees which can be regarded a natural experiment to investigate the influence of regional factors on recent immigrants' locational choices. The main push factors are lack of co-ethnics and presence of immigrants. Additional push factors...... are lack of access to jobs, education and housing which explain why recent immigrants are attracted to large cities. Finally, placed refugees are sensitive to regional unemployment and some evidence of welfare seeking is presented as well....

  13. Immigration and Outsourcing: A General Equilibrium Analysis

    OpenAIRE

    Subhayu Bandoyopadhyay; Wall, Howard J.

    2005-01-01

    This paper analyzes the issues of immigration and outsourcing in a general-equilibrium model of international factor mobility. In our model, legal immigration is controlled through a quota, while outsourcing is determined both by the firms (in response to market conditions) and through policy-imposed barriers. A loosening of the immigration quota reduces outsourcing, enriches capitalists, leads to losses for native workers, and raises national income. If the nation targets an exogenously dete...

  14. Immigration, education and native wage inequality

    OpenAIRE

    Lumpe, Christian; Weigert, Benjamin

    2010-01-01

    In this paper we analyse the effect of immigration on the labour market prospects for different skill groups among natives. We develop a model of endogenous labour supply in which immigration affects educational decisions of natives. We argue that the distributional consequences of immigration with respect to native between-skill-group inequality are ambiguous in general and crucially depend on the host country's level of educational attainment. We show that this result is robust irrespective...

  15. Illegal Immigration: Optimal Enforcement and Capital Mobility

    OpenAIRE

    Subhayu Bandyopadhyay

    2005-01-01

    This paper analyzes the effectiveness of enforcement in controlling illegal immigration in two scenarios, capital mobility and capital immobility in the host nation (for illegal immigrants). The source nation is assumed throughout to have immobility of capital. We show that the net enforcement expenditure is higher (lower) in the presence of capital mobility if the host nation is an importer (exporter) of capital at the target immigration level. Furthermore, we show that if the host nation is...

  16. Detecting immigration by using multilocus genotypes

    OpenAIRE

    Rannala, Bruce; Mountain, Joanna L.

    1997-01-01

    Immigration is an important force shaping the social structure, evolution, and genetics of populations. A statistical method is presented that uses multilocus genotypes to identify individuals who are immigrants, or have recent immigrant ancestry. The method is appropriate for use with allozymes, microsatellites, or restriction fragment length polymorphisms (RFLPs) and assumes linkage equilibrium among loci. Potential applications include studies of dispersal among natural populations of anim...

  17. Immigrant Job Search Assimilation in Canada

    OpenAIRE

    Bowlus, Audra J.; Miyairi, Masashi; Robinson, Chris

    2013-01-01

    Immigrant assimilation is a major issue in many countries. While most of the literature studies assimilation through a human capital framework, we examine the role of job search assimilation. To do so, we estimate an equilibrium search model of immigrants operating in the same labor market as natives, where newly arrived immigrants have lower job offer arrival rates than natives but can acquire the same arrival rates according to a stochastic process. Using Canadian panel data, we find substa...

  18. Immigration and the Interplay among Citizenship, Identity and Career: The Case of Ethiopian Immigration to Israel

    Science.gov (United States)

    Flum, Hanoch; Cinamon, Rachel Gali

    2011-01-01

    Migration is a common phenomenon of the globalization era. In this article we explore the interplay of three foundational concepts in the migration experiences of Ethiopian Jewish immigrants in Israel: citizenship, identity and career. Through our analysis we examine the multiple layers of being an immigrant citizen. Following immigration, as…

  19. Health Insurance Disparities among Immigrants: Are Some Legal Immigrants More Vulnerable than Others?

    Science.gov (United States)

    Pandey, Shanta; Kagotho, Njeri

    2010-01-01

    This study examined health insurance disparities among recent immigrants. The authors analyzed all working-age adult immigrants between the ages of 18 and 64 using the New Immigrant Survey data collected in 2003. This survey is a cross-sectional interview of recent legal permanent residents on their social, economic, and health status. Respondents…

  20. Citizenship and the Social Integration of Immigrants: Evidence from Germany's Immigration Reforms

    OpenAIRE

    Keller, Nicolas; Gathmann, Christina; Monscheuer, Ole

    2015-01-01

    We study whether the option to naturalize improves social and cultural integration of immigrants in the host country. The empirical analysis relies on two immigration reforms in Germany, a country with a traditionally weak record of immigrant integration both in terms of labor market performance but also social integration. For identi

  1. Assimilation Attitudes Predict Lower Immigration-Related Self-Efficacy among Israeli Immigrant Teachers

    Science.gov (United States)

    Tatar, Moshe; Ben-Uri, Ina; Horenczyk, Gabriel

    2011-01-01

    This study focuses on self-efficacy among teachers working in culturally diverse educational contexts. We put forward the notion of immigration-related self-efficacy and provide initial support for its relationship with the acculturation attitudes held by immigrant teachers. One hundred thirty-three teachers who immigrated to Israel from the…

  2. Immigrants as Active Citizens: Exploring the Volunteering Experience of Chinese Immigrants in Vancouver

    Science.gov (United States)

    Guo, Shibao

    2014-01-01

    Despite the fact that immigration has played an important role in transforming Canada into an ethno-culturally diverse and economically prosperous nation, immigrants themselves are often criticised as passive citizens. This study attempts to deconstruct this myth by investigating the volunteering experiences of Chinese immigrants in Vancouver. The…

  3. Selective immigration policy in Australia, Canada, and the United States

    OpenAIRE

    Antecol, Heather; Cobb-Clark, Deborah A.; Stephen J. Trejo

    2004-01-01

    We compare the selective immigration policies in Australia, Canada and the United States over the twentieth century and as they exist today. We then review existing information about the link between selective immigration policy and immigration outcomes in the three countries. The literature reviewed suggests that there does seem to be potential for selective immigration policy to affect immigrant outcomes by altering the skill levels of immigrants. Still, it is clear that other forces are at...

  4. Gendered Immigration: Implications and Impact on Social Work Education

    OpenAIRE

    DeBrenna LaFa Agbényiga; Lihua Huang

    2012-01-01

    Gendered immigration is a frame of reference for contextualizing the need for gender-specific immigrant services. Like other immigration societies, the United States disproportionately pays less attention to immigrant women. This article is a conceptual examination of the critical challenges faced by immigrant women from a global perspective. Special attention is given to the importance of social work education regarding service delivery structures for an increasing number of immigrant women ...

  5. Settlement Policies and the Economic Success of Immigrants

    OpenAIRE

    Edin, Per-Anders; Fredriksson, Peter; Åslund, Olof

    2001-01-01

    Many developed countries, e.g. the UK, Germany, and Sweden, use or have used settlement policies to direct the inflow of new immigrants away from immigrant dense metropolitan areas. We evaluate a reform of Swedish immigration policy that featured dispersion of refugee immigrants across the country, but also a change in the approach to labour market integration. We focus exclusively on how immigrants fared because of the policy. The results indicate that immigrants experienced fairly substanti...

  6. Settlement and migration patterns among immigrants in Norway

    OpenAIRE

    Stambøl, Lasse Sigbjørn

    2014-01-01

    The immigration to Norway has increased strongly since the turn of the millennium and especially since the eastward EU-enlargements. The aim of the paper is to investigate the regional settlement and migration patterns of immigrants mostly recognized by their reason of immigration. The immigration has changed from a gender balance during the first years of the 2000 towards a clear male dominance after 2005, mostly due to increased labour immigration. The immigration has changed from a dominan...

  7. Immigrants'assimilation process in a segmented labor market

    OpenAIRE

    Rodríguez Planas, Núria; Alcobendas, Miguel Angel

    2010-01-01

    While much of the literature on immigrants' assimilation has focused on countries with a large tradition of receiving immigrants and with flexible labor markets, very little is known on how immigrants adjust to other types of host economies. With its severe dual labor market, and an unprecedented immigration boom, Spain presents a quite unique experience to analyze immigrations' assimilation process. Using data from the 2000 to 2008 Labor Force Survey, we find that immigrants are more occupat...

  8. Immigrants' Assimilation Process In A Segmented Labor Market

    OpenAIRE

    Miguel Ángel Alcobendas; Núria Rodríquez-Planas

    2010-01-01

    While much of the literature on immigrants' assimilation has focused on countries with a large tradition of receiving immigrants and with flexible labor markets, very little is known on how immigrants adjust to other types of host economies. With its severe dual labor market, and an unprecedented immigration boom, Spain presents a quite unique experience to analyze immigrations' assimilation process. Using data from the 2000 to 2008 Labor Force Survey, we find that immigrants are more occupat...

  9. The labour market impact of immigration : theory and evidence

    OpenAIRE

    Lumpe, Christian

    2007-01-01

    In this survey, we compare the history and status of immigration of a traditional immigration county (the US) with the experiences of a new immigration country (Germany). This reveals differences in the immigration policy as in the immigration population in the respective countries. We resume the theoretical model implications which the existing immigration should have had on the labour market outcome of natives. This takes into account the differing labour market institutions in both countri...

  10. DO IMMIGRANTS ROB JOBS? A CASE STUDY OF AUSTRALIA

    OpenAIRE

    Hsiao-chuan Chang

    2003-01-01

    This paper constructs a dynamic theoretical model and calibrates the model with the Australian data. The simulations provide new findings which demonstrate that skilled immigrants are not ‘job robbers’ but unskilled immigrants have the potential to become such. The result that immigrants are not job robbers is due to there having been a much larger number of skilled immigrants than the unskilled immigrants in Australia during the past twelve years, 1990-2002. The immigration policy adopted by...

  11. Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.

    Science.gov (United States)

    Shen, John Paul; Srivas, Rohith; Gross, Andrew; Li, Jianfeng; Jaehnig, Eric J; Sun, Su Ming; Bojorquez-Gomez, Ana; Licon, Katherine; Sivaganesh, Vignesh; Xu, Jia L; Klepper, Kristin; Yeerna, Huwate; Pekin, Daniel; Qiu, Chu Ping; van Attikum, Haico; Sobol, Robert W; Ideker, Trey

    2015-11-01

    Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we screened 112 known tumor suppressor genes for synthetic lethal interactions with inhibitors of the CHEK1 and CHEK2 checkpoint kinases. We identified eight interactions, including the Replication Factor C (RFC)-related protein RAD17. Clonogenic assays in RAD17 knockdown cell lines identified a substantial shift in sensitivity to checkpoint kinase inhibition (3.5-fold) as compared to RAD17 wild-type. Additional evidence for this interaction was found in a large-scale functional shRNA screen of over 100 genotyped cancer cell lines, in which CHEK1/2 mutant cell lines were unexpectedly sensitive to RAD17 knockdown. This interaction was widely conserved, as we found that RAD17 interacts strongly with checkpoint kinases in the budding yeast Saccharomyces cerevisiae. In the setting of RAD17 knockdown, CHEK1/2 inhibition was found to be synergistic with inhibition of WEE1, another pharmacologically relevant checkpoint kinase. Accumulation of the DNA damage marker γH2AX following chemical inhibition or transient knockdown of CHEK1, CHEK2 or WEE1 was magnified by knockdown of RAD17. Taken together, our data suggest that CHEK1 or WEE1 inhibitors are likely to have greater clinical efficacy in tumors with RAD17 loss-of-function. PMID:26437225

  12. Immigration Reform: Implications for Agriculture

    OpenAIRE

    Martin, Philip L.

    2006-01-01

    About half of U.S. farm workers are not authorized to work in the United States. Pending immigration reforms aim to prevent the entry and employment of more unauthorized foreigners, but they differ on what to do about unauthorized workers already in the United States. These unauthorized workers are not likely to disappear overnight, and agricultural adjustments to a legal work force are likely to be determined by enforcement patterns, the structure of new guest worker programs, and the speed ...

  13. Immigration, remittances, and business cycles

    OpenAIRE

    Federico S. Mandelman; Zlate, Andrei

    2010-01-01

    We use data on border enforcement and macroeconomic indicators from the United States and Mexico to estimate a two-country business cycle model of labor migration and remittances. The model matches the cyclical dynamics of labor migration to the United States and documents how remittances to Mexico serve an insurance role to smooth consumption across the border. During expansions in the destination economy, immigration increases with the expected stream of future wage gains, but it is dampene...

  14. SPAIN: FROM IMMIGRATION TO EMIGRATION?

    OpenAIRE

    Mario Izquierdo; Juan F. Jimeno; Aitor Lacuesta

    2015-01-01

    Since the start of the Great Recession the unemployment rate in Spain has risen by almost 18 percentage points. The unemployment crisis is affecting all population groups, including the more highly educated; but it is even more acute for the foreign population, whose unemployment rate is close to 40%. This situation follows a period of very high immigration flows (1995-2007) that set the number of foreigners living in Spain at 11% of the population. This paper documents the characteristics of...

  15. What institutions help immigrants Integrate?

    OpenAIRE

    Huber, Peter

    2015-01-01

    WWWforEurope Working Paper No. 77, 38 pages I analyse the importance of national migration policy and labour market institutions for immigrants’ labour market integration. Results indicate that the sending country structure of immigrants to a country, its ethnic diversity and its wage bargaining institutions as well as product market regulation are the most important national institutions impacting immigrants’ labour market integration. Variables related to the generosity of the welfare state...

  16. Financial assimilation of immigrants conference

    OpenAIRE

    anonymous

    2003-01-01

    On June 24, the Consumer and Community Affairs division of the Federal Reserve Bank of Chicago convened, “An Informed Discussion of the Financial Assimilation of Immigrants” in Des Moines, Iowa. The conference was part of the larger, long-term program by the Chicago Reserve Bank to study the ways and means by which immigrants to the United States access mainstream financial services. This Special Edition of PNV comprises summaries of each of the conference presentations.

  17. Immigration in Europe, security, terrorism

    OpenAIRE

    Campani, G

    2008-01-01

    The paper analyzes how the integration of Muslim minorities has become a highly politicized matter all over Europe, raising questions about the forms of recognition that should be granted by the European states to immigrant minorities in order to allow them to keep their religious and cultural specificities in the frame of European laws and values. It considers then the lonks between Islamophobia and the attraction towards fundamentalism by young people who present a complex double identit...

  18. The meiotic recombination checkpoint suppresses NHK-1 kinase to prevent reorganisation of the oocyte nucleus in Drosophila.

    Directory of Open Access Journals (Sweden)

    Oscar M Lancaster

    2010-10-01

    Full Text Available The meiotic recombination checkpoint is a signalling pathway that blocks meiotic progression when the repair of DNA breaks formed during recombination is delayed. In comparison to the signalling pathway itself, however, the molecular targets of the checkpoint that control meiotic progression are not well understood in metazoans. In Drosophila, activation of the meiotic checkpoint is known to prevent formation of the karyosome, a meiosis-specific organisation of chromosomes, but the molecular pathway by which this occurs remains to be identified. Here we show that the conserved kinase NHK-1 (Drosophila Vrk-1 is a crucial meiotic regulator controlled by the meiotic checkpoint. An nhk-1 mutation, whilst resulting in karyosome defects, does so independent of meiotic checkpoint activation. Rather, we find unrepaired DNA breaks formed during recombination suppress NHK-1 activity (inferred from the phosphorylation level of one of its substrates through the meiotic checkpoint. Additionally DNA breaks induced by X-rays in cultured cells also suppress NHK-1 kinase activity. Unrepaired DNA breaks in oocytes also delay other NHK-1 dependent nuclear events, such as synaptonemal complex disassembly and condensin loading onto chromosomes. Therefore we propose that NHK-1 is a crucial regulator of meiosis and that the meiotic checkpoint suppresses NHK-1 activity to prevent oocyte nuclear reorganisation until DNA breaks are repaired.

  19. Immigration Enforcement Actions: Fiscal Year 2011

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  20. [Measles and chickenpox susceptibility among immigrants].

    Science.gov (United States)

    Gétaz, Laurent; Casillas, Alejandra; Wolff, Hans

    2016-05-01

    Exposure of immigrants to infectious diseases in their country of origin influences their susceptibility to infections later in life. Susceptibility to certain infections may significantly differs between immigrants depending on their regions of origin. Both measles and chickenpox (varicella) are conditions for which the level of exposure in the country of origin influences the preventive measures that immigrant health providers should propose. Through these two illustrative examples, this article summarizes the practical implications for clinicians who care for immigrants originating from southern countries. PMID:27323481

  1. Immigration Enforcement Actions: Fiscal Year 2010

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  2. Immigration Enforcement Actions: Fiscal Year 2009

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  3. Immigration Enforcement Actions: Fiscal Year 2007

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  4. Immigration Enforcement Actions: Fiscal Year 2012

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  5. Immigration Enforcement Actions: Fiscal Year 2004

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  6. Immigration Enforcement Actions: Fiscal Year 2006

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  7. Immigration Enforcement Actions: Fiscal Year 2008

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  8. Environmental and Occupational Exposures in Immigrant Health

    Directory of Open Access Journals (Sweden)

    Pracha P. Eamranond

    2008-01-01

    Full Text Available Immigrants comprise vulnerable populations that are frequently exposed to a multitude of environmental and occupational hazards. The historical context behind state and federal legislation has helped to foster an environment that is particularly hostile toward caring for immigrant health. Current hazards include toxic exposures, air and noise pollution, motor vehicle accidents, crowded living and work environments with inadequate ventilation, poor sanitation, mechanical injury, among many others. Immigrants lack the appropriate training, materials, health care access, and other resources to reduce their exposure to preventable environmental and occupational health risks. This dilemma is exacerbated by current anti-immigrant sentiments, miscommunication between native and immigrant populations, and legislation denying immigrants access to publicly funded medical care. Given that current health policy has failed to address immigrant health appropriately and political impetus is lacking, efforts should also focus on alternative solutions, including organized labor. Labor unions that serve to educate workers, survey work environments, and defend worker rights will greatly alleviate and prevent the burden of disease incurred by immigrants. The nation’s health will benefit from improved regulation of living and workplace environments to improve the health of immigrants, regardless of legal status.

  9. Immigration Enforcement Actions: Fiscal Year 2005

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  10. EMPLOYMENT OF RUSSIAN IMMIGRANTS IN FINLAND

    OpenAIRE

    Sinkevitch, Dimitri

    2011-01-01

    There are 150,000 immigrants in Finland. Russians are the second largest group after Estonians. The main purpose of this thesis was to help Russian immigrant get em-ployed in Finland. I tried to map the problems areas through interviews with both Russian immigrants and Finnish employers. The first issue of my theoretical part was to explain who the immigrants are, and what the reasons for migration are. The second part deals with cultural differences, which is supported by Geert Hofstede’s 5D...

  11. The Europeanisation of immigration politics

    Directory of Open Access Journals (Sweden)

    Adrian Favell

    1998-12-01

    Full Text Available With the 1996-7 IGC and signing of the Amsterdam Treaty, immigration has moved towards the top of the EU policy agenda. This paper offers an overview of developments on immigration, asylum and citizenship. It goes on to develop a sociological approach to Europeanisation, which identifies the principle actors and organisations which constitute the emerging ‘political field’ of immigration at the EU level. In particular, it discusses in detail the growing presence of NGOs in Brussels, and their strategies for influencing EU policy making. It also relates the success of these ‘transnational’ organisations to other forms of transnational cooperation between networks of European police and security experts, and between region and city networks. To understand in sociological terms the specific forms of empowerment enabled to certain groups by European integration, it is necessary to show how successful actors in the European circles have created new forms of social and cultural ‘capital’ beyond the nation state.

  12. USCIS Applications for Immigration Benefits and Naturalization Monthly Statistical Reports

    Data.gov (United States)

    Department of Homeland Security — The 'Application for Immigration Benefits' monthly charts provide data on applications and petitions received by USCIS for immigration benefits. The report exclude...

  13. Immigrant Networks and the U.S. Bilateral Trade: the Role of Immigrant Income

    OpenAIRE

    Kusum Mundra

    2010-01-01

    This paper examines the role of immigrant networks on trade, particulalry through the demand effect. First, we examine the effect of immigration on trade when the immigrants consume more of the goods that are abundant in their home country than the natives in a standard Heckscher-Ohlin model and find that the effect of immigration on trade is a priori indeterminate. Our econometric gravity model consists of 63 major trading and immigrant sending countries for the U.S. over 1991 - 2000. We fin...

  14. Immigrant Networks and U.S. Bilateral Trade: The Role of Immigrant Income

    OpenAIRE

    Mundra, Kusum

    2010-01-01

    This paper examines the role of immigrant networks on trade, particularly through the demand effect. First, we examine the effect of immigration on trade when the immigrants consume more of the goods that are abundant in their home country than the natives in a standard Heckscher-Ohlin model and find that the effect of immigration on trade is a priori indeterminate. Our econometric gravity model consists of 63 major trading and immigrant sending countries for the U.S. over 1991-2000. We find ...

  15. Immigrant networks and US bilateral trade: The role of immigrant income

    OpenAIRE

    Mundra, Kusum

    2010-01-01

    This paper examines the role of immigrant networks on trade, particularly through the demand effect. First, we examine the effect of immigration on trade when the immigrants consume more of the goods that are abundant in their home country than the natives in a standard Heckscher-Ohlin model and find that the effect of immigration on trade is a priori indeterminate. Our econometric gravity model consists of 63 major trading and immigrant sending countries for the US over 1991-2000. We find th...

  16. The Relationship Between Immigrant School Composition, Classmate Support and Involvement in Physical Fighting and Bullying among Adolescent Immigrants and Non-immigrants in 11 Countries.

    Science.gov (United States)

    Walsh, Sophie D; De Clercq, Bart; Molcho, Michal; Harel-Fisch, Yossi; Davison, Colleen M; Madsen, Katrine Rich; Stevens, Gonneke W J M

    2016-01-01

    Increasing numbers of migrant youth around the world mean growing numbers of heterogeneous school environments in many countries. Contradictory findings regarding the relationship between immigrant school composition (the percentage of immigrant versus non-immigrant students in a school) and adolescent peer violence necessitate further consideration. The current study examined the relationship between immigrant school composition and peer violence, considering classmate support as a potential moderator among 51,636 adolescents (50.1% female) from 11 countries. The findings showed that a higher percentage of immigrant adolescents in a school was related to higher levels of physical fighting and bullying perpetration for both immigrant and non-immigrant adolescents and lower levels of victimization for immigrants. In environments of low classmate support, the positive relationship between immigrant school composition and fighting was stronger for non-immigrants than in environments with high classmate support. In environments of low classmate support, the negative relationship between immigrant school composition and fighting and bullying victimization was stronger for immigrant adolescents than in environments with high classmate support. In general, the contribution of immigrant school composition was modest in comparison to the contribution of classmate support. The findings emphasize that it is not just the number of immigrants in a class per se, but rather the environment in the classroom which influences levels of peer violence. The results highlight a need for school intervention programs encouraging positive relations in schools with immigrant populations. PMID:26502194

  17. How not to argue about immigration

    Directory of Open Access Journals (Sweden)

    Corlett Angelo J.

    2013-01-01

    Full Text Available This paper describes and assesses the arguments offered both against closed borders and in favor of a more open borders approach to U.S. immigration reform as those arguments are set forth in R. Pevnick’s book, Immigration and the Constraints of Justice. We find numerous problems with Pevnick’s reasoning on both counts.

  18. Immigrant Qualifications: Recognition and Relative Wage Outcomes.

    Science.gov (United States)

    Chapman, Bruce J.; Iredale, Robyn R.

    1993-01-01

    Uses a dataset compiled by the Australian government to examine the qualifications of ostensibly skilled immigrants. Around 39% of immigrants have chosen to subject their qualifications to local assessment, and about 42% of these have been recognized as equivalent to Australian counterparts. Wage considerations are discussed. (SLD)

  19. Do Immigrants Affect Firm-Specific Wages?

    DEFF Research Database (Denmark)

    Malchow-Møller, Nikolaj; Munch, Jakob R.; Skaksen, Jan Rose

    2012-01-01

    formation at the most disaggregate level – the workplace. Using linked employer-employee data, we find that an increased use of low-skilled immigrant workers has a significantly negative effect on the wages of native workers at the workplace – also when controlling for potential endogeneity of the immigrant...

  20. David Miller on Immigration Policy and Nationality

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2007-01-01

    determinative of the scope of distributive justice and as giving rise to national collective responsibility. Three interpretations of his main positive reason for restricting immigration, which concerns the importance of a shared public culture, are then discussed: culture as having valuable social functions...... insignificant in relation to immigration policy....

  1. Immigrant Success Stories in ESL Textbooks

    Science.gov (United States)

    Gulliver, Trevor

    2010-01-01

    Immigrant success stories found in English as a second language (ESL) textbooks used in government-funded language instruction in Canada imagine Canada as a redeemer of immigrant newcomers. Through a critical discourse analysis of ESL textbooks used in Language Instruction for Newcomers to Canada classes in Ontario, I identify two primary…

  2. Immigration Policy and Self-Selecting Migrants

    OpenAIRE

    BIANCHI, MILO

    2013-01-01

    We build a simple model of self-selection into migration and immigration policy determination. We first show that the effect of any immigration policy can be decomposed into a size and a composition effect. We then explore how the optimal policy may change once the latter effect is considered.

  3. Immigration Policy and Self-Selecting Migrants

    OpenAIRE

    Milo Bianchi

    2012-01-01

    We build a simple model of self-selection into migration and immigration policy determination. We first show that the effect of any immigration policy can be decomposed into a size and a composition effect. We then explore how the optimal policy may change once the latter effect is considered.

  4. Academic Trajectories of Newcomer Immigrant Youth

    Science.gov (United States)

    Suarez-Orozco, Carola; Gaytan, Francisco X.; Bang, Hee Jin; Pakes, Juliana; O'Connor, Erin; Rhodes, Jean

    2010-01-01

    Immigration to the United States presents both challenges and opportunities that affect students' academic achievement. Using a 5-year longitudinal, mixed-methods approach, we identified varying academic trajectories of newcomer immigrant students from Central America, China, the Dominican Republic, Haiti, and Mexico. Latent class growth curve…

  5. The Living Arrangements of Children of Immigrants

    Science.gov (United States)

    Landale, Nancy S.; Thomas, Kevin J. A.; Van Hook, Jennifer

    2011-01-01

    Children of immigrants are a rapidly growing part of the U.S. child population. Their health, development, educational attainment, and social and economic integration into the nation's life will play a defining role in the nation's future. Nancy Landale, Kevin Thomas, and Jennifer Van Hook explore the challenges facing immigrant families as they…

  6. Building the Civic Potential of Immigrant Youth

    Science.gov (United States)

    Obenchain, Kathryn M.; Callahan, Rebecca M.

    2014-01-01

    Social studies emerged at the core of the American common school in the mid-nineteenth century amid the rise of the urban immigrant receiving center. These two forces together resulted in the heightened importance of schools in transforming immigrant students into American citizens. Today, U.S. schools often serve as a social and educational nexus…

  7. The Nordic Council and Immigrant Education Policy.

    Science.gov (United States)

    Johnson, Kristi Planck

    Cooperation among Scandinavian nations (Norway, Denmark, Finland, and Sweden) is important in order to develop an effective policy regarding the education of immigrants and refugees. Each of the Scandinavian countries has a definitive education policy for refugees and immigrants. However, cooperative efforts among the nations through the Nordic…

  8. LGBT Adult Immigrants in the United States

    OpenAIRE

    Gates, Gary J.

    2013-01-01

    There are approximately 267,000 LGBT-identified individuals among the adult undocumented immigrant population and an estimated 637,000 LGBT-identified individuals among the adult documented immigrant population. The report finds that approximately 71 percent of undocumented LGBT adults are Hispanic and 15 percent of undocumented LGBT adults are Asian or Pacific Islander.

  9. Critical Quantitative Study of Immigrant Students

    Science.gov (United States)

    Conway, Katherine M.

    2014-01-01

    The author discusses the importance of critical quantitative research for studies of immigrant students, a large and growing group, whose higher education experience is crucial to the future of the United States. The author outlines some of the distinctions to be made among immigrant students and recommends areas of future inquiry.

  10. Immigrant Students and the Obstacles to Achievement

    Science.gov (United States)

    Stratton, Tamiko; Pang, Valerie Ooka; Madueno, Marcelina; Park, Cynthia D.; Atlas, Miriam; Page, Cindy; Oliger, Jennifer

    2009-01-01

    This article describes composites of actual students, but examples of hardworking immigrant students and their families can be found in every state. Many young immigrants are negotiating their place in society. They believe in the American Dream and struggle with issues of poverty, language, cultural assimilation, and the desire to further their…

  11. 49 CFR 1572.105 - Immigration status.

    Science.gov (United States)

    2010-10-01

    ... United States under 8 CFR 214.2(b)(4)(i)(E) to conduct business in the United States. (b) Upon expiration... 49 Transportation 9 2010-10-01 2010-10-01 false Immigration status. 1572.105 Section 1572.105... ASSESSMENTS Standards for Security Threat Assessments § 1572.105 Immigration status. (a) An...

  12. Second-Language Literacy, Immigration, and Globalization

    Science.gov (United States)

    Soto Huerta, M. E.; Pérez, B.

    2015-01-01

    Second language literacy development is a significant factor influencing immigrants' opportunities to integrate with the host society. To examine the opportunities that different immigrant groups have had for obtaining both, we selected four published studies that had been originally analyzed through a sociocultural perspective, a prominent…

  13. Connecting the Immigrant Experience through Literature

    Science.gov (United States)

    Allen, Eliza G.

    2016-01-01

    A 3rd-grade teacher used literature to help her immigrant students grapple with some of the larger issues related to immigration. Through the story of one Latino student, the teacher shares the literature that she used and how one student responded.

  14. K-12 educational outcomes of immigrant youth.

    Science.gov (United States)

    Crosnoe, Robert; Turley, Ruth N López

    2011-01-01

    The children from immigrant families in the United States make up a historically diverse population, and they are demonstrating just as much diversity in their experiences in the K-12 educational system. Robert Crosnoe and Ruth López Turley summarize these K-12 patterns, paying special attention to differences in academic functioning across segments of the immigrant population defined by generational status, race and ethnicity, and national origin. A good deal of evidence points to an immigrant advantage in multiple indicators of academic progress, meaning that many youths from immigrant families outperform their peers in school. This apparent advantage is often referred to as the immigrant paradox, in that it occurs despite higher-than-average rates of social and economic disadvantages in this population as a whole. The immigrant paradox, however, is more pronounced among the children of Asian and African immigrants than other groups, and it is stronger for boys than for girls. Furthermore, evidence for the paradox is far more consistent in secondary school than in elementary school. Indeed, school readiness appears to be one area of potential risk for children from immigrant families, especially those of Mexican origin. For many groups, including those from Latin America, any evidence of the immigrant paradox usually emerges after researchers control for family socioeconomic circumstances and youths' English language skills. For others, including those from Asian countries, it is at least partially explained by the tendency for more socioeconomically advantaged residents of those regions to leave their home country for the United States. Bilingualism and strong family ties help to explain immigrant advantages in schooling; school, community, and other contextual disadvantages may suppress these advantages or lead to immigrant risks. Crosnoe and Turley also discuss several policy efforts targeting young people from immigrant families, especially those of Latin

  15. Community unemployment and immigrants' health in Montreal.

    Science.gov (United States)

    Zunzunegui, Maria-Victoria; Forster, Mathieu; Gauvin, Lise; Raynault, Marie-France; Douglas Willms, J

    2006-07-01

    This research examines the relationship between community unemployment and the physical and mental health of immigrants in comparison to non-immigrants in Montreal under the hypothesis that high unemployment in the community may generate more negative effects on the health of immigrants than on non-immigrants. Possible gender differences in these associations are also examined. Montreal residents were studied via multilevel analysis, using both individual survey data and neighbourhood data from 49 police districts. Individual-level data were excerpted from a 1998 health survey of Montreal residents, while neighbourhood data originated from survey data collected in the 49 Montreal police districts and the 1996 Canadian Census. The associations between community unemployment and self-rated health, psychological distress and obesity are examined, and hypotheses regarding the modifying mechanisms via which male and female immigrants may run a greater risk of poor health than non-immigrants when living in areas of high unemployment were tested. Between neighbourhoods, variations in the three health outcomes were slight, and differences in health were not associated with differences in community unemployment. The associations between community unemployment and health varied according to immigration status. At the individual level, immigrants do not differ from non-immigrants with respect to the three health indicators, except that second-generation males are slightly heavier. However, when living in areas of high unemployment, immigrants tend to report poor physical and mental health in comparison to non-immigrants. Among first-generation immigrants, community unemployment was associated with psychological distress. Among second-generation immigrants, the probability of obesity and poor self-rated health increased significantly for those living in areas with high unemployment, but these associations reached statistical significance only for men. Findings among first

  16. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

    DEFF Research Database (Denmark)

    Reinhardt, H Christian; Hasskamp, Pia; Schmedding, Ingolf;

    2010-01-01

    Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the p38/MK2 pathway for survival after DNA damage, despite a functional ATR-Chk1...... pathway. We used functional genetics to dissect the contributions of Chk1 and MK2 to checkpoint control. We show that nuclear Chk1 activity is essential to establish a G(2)/M checkpoint, while cytoplasmic MK2 activity is critical for prolonged checkpoint maintenance through a process of...... posttranscriptional mRNA stabilization. Following DNA damage, the p38/MK2 complex relocalizes from nucleus to cytoplasm where MK2 phosphorylates hnRNPA0, to stabilize Gadd45α mRNA, while p38 phosphorylates and releases the translational inhibitor TIAR. In addition, MK2 phosphorylates PARN, blocking Gadd45α m...

  17. Festival foods in the immigrant diet.

    Science.gov (United States)

    Azar, Kristen M J; Chen, Edith; Holland, Ariel T; Palaniappan, Latha P

    2013-10-01

    Dietary acculturation for immigrant groups has largely been attributed to the "Westernization" of indigenous diets, as characterized by an increased consumption of unhealthy American foods (i.e., fast foods, hamburgers). However, acculturation and adoption of western dietary habits may not fully explain new dietary patterns among racial/ethnic minority immigrants. The immigrant diet may change in such a way that it elaborates on specific ethnic traditions in addition to the incorporation of Western food habits. In this paper, we explore the role that festival foods, those foods that were once eaten a few times a year and on special occasions, play in the regular diet of immigrants to the US. This paper will focus on the overconsumption of ethnic festival foods, which are often high in carbohydrates, animal protein, sugar and fat, as opposed to Western "junk" food, as an explanation for the increased risk of cardiometabolic disorders among new immigrant groups. PMID:22968231

  18. What is the Right to Exclude Immigrants?

    DEFF Research Database (Denmark)

    Lægaard, Sune

    2010-01-01

    It is normally taken for granted that states have a right to control immigration into their territory. When immigration is raised as a normative issue two questions become salient, one about what the right to exclude is, and one about whether and how it might be justified. This paper considers the...... immigration at all, which results in state discretion positions. This state of debate is both theoretically unsatisfactory and normatively implausible. The paper therefore explores an alternative approach to the right to exclude immigrants from the perspective of recent debates about the territorial rights of...... states. The right to exclude claimed by states is analysed and it is shown to differ both conceptually and normatively from rights to impose political authority within a territory. The paper finally indicates how this analysis might broaden the focus of debates about immigration and suggest alternative...

  19. The Contributions of Immigrants to American Culture.

    Science.gov (United States)

    Hirschman, Charles

    2013-01-01

    The standard account of American immigration focuses on the acculturation and assimilation of immigrants and their children to American society. This analysis typically ignores the significant contributions of immigrants to the creation of American culture through the performing arts, sciences, and other cultural pursuits. Immigrants and their children are not born with more creative talents than native-born citizens, but their selectivity and marginality may have pushed and pulled those with ability into high-risk career paths that reward creative work. The presence of large numbers of talented immigrants in Hollywood, academia, and the high-tech industries has pushed American institutions to be more meritocratic and open to innovation than they would be otherwise. PMID:24339451

  20. Association between Integration Policies and Immigrants' Mortality

    DEFF Research Database (Denmark)

    Ikram, Umar Z; Malmusi, Davide; Juel, Knud;

    2015-01-01

    BACKGROUND: To integrate immigrants into their societies, European countries have adopted different types of policies, which may influence health through both material and psychosocial determinants. Recent studies have suggested poorer health outcomes for immigrants living in countries with poorly...... rated integration policies. OBJECTIVE: To analyse mortality differences of immigrants from the same country of origin living in countries with distinct integration policy contexts. METHODS: From the mortality dataset collected in the Migrant Ethnic Health Observatory (MEHO) project, we chose the...... peers in the Netherlands, Turkish-born immigrants had higher all-cause mortality in Denmark (MRR men 1.92; 95% CI 1.74-2.13 and women 2.11; 1.80-2.47) but lower in France (men 0.64; 0.59-0.69 and women 0.58; 0.51-0.67). A similar pattern emerged for Moroccan-born immigrants. The relative differences...

  1. Ghost Process: a Sound Basis to Implement Process Duplication, Migration and Checkpoint-Restart in Linux Clusters

    OpenAIRE

    Vallée, Geoffroy; Lottiaux, Renaud; Margery, David; Morin, Christine; Berthou, Jean-Yves

    2005-01-01

    Process management mechanisms (process duplication, migration and checkpoint-restart) are very useful for high performance and high availability in clustering systems. The single system image approach aims at providing a global process management service with mechanisms for process checkpoint, process migration and process duplication. In this context, a common mechanism for process virtualization is highly desirable but traditional operating systems do not provide such a mechanism. This pape...

  2. DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

    OpenAIRE

    Marangos, P; Stevense, M.; Niaka, K.; Lagoudaki, M.; Nabti, I.; Jessberger, R.; Carroll, J.

    2015-01-01

    In mammalian oocytes DNA damage can cause chromosomal abnormalities that potentially lead to infertility and developmental disorders. However, there is little known about the response of oocytes to DNA damage. Here we find that oocytes with DNA damage arrest at metaphase of the first meiosis (MI). The MI arrest is induced by the spindle assembly checkpoint (SAC) because inhibiting the SAC overrides the DNA damage-induced MI arrest. Furthermore, this MI checkpoint is compromised in oocytes fro...

  3. Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G1 checkpoint function

    Directory of Open Access Journals (Sweden)

    Simpson Dennis

    2005-01-01

    Full Text Available Abstract Background Secondary cultures of human fibroblasts display a finite lifespan ending at senescence. Loss of p53 function by mutation or viral oncogene expression bypasses senescence, allowing cell division to continue for an additional 10 – 20 doublings. During this time chromosomal aberrations seen in mitotic cells increase while DNA damage and decatenation checkpoint functions in G2 cells decrease. Methods To explore this complex interplay between chromosomal instability and checkpoint dysfunction, human fibroblast lines were derived that expressed HPV16E6 oncoprotein or dominant-negative alleles of p53 (A143V and H179Q with or without the catalytic subunit of telomerase. Results Cells with normal p53 function displayed 86 – 93% G1 arrest after exposure to 1.5 Gy ionizing radiation (IR. Expression of HPV16E6 or p53-H179Q severely attenuated G1 checkpoint function (3 – 20% arrest while p53-A143V expression induced intermediate attenuation (55 – 57% arrest irrespective of telomerase expression. All cell lines, regardless of telomerase expression or p53 status, exhibited a normal DNA damage G2 checkpoint response following exposure to 1.5 Gy IR prior to the senescence checkpoint. As telomerase-negative cells bypassed senescence, the frequencies of chromosomal aberrations increased generally congruent with attenuation of G2 checkpoint function. Telomerase expression allowed cells with defective p53 function to grow >175 doublings without chromosomal aberrations or attenuation of G2 checkpoint function. Conclusion Thus, chromosomal instability in cells with defective p53 function appears to depend upon telomere erosion not loss of the DNA damage induced G1 checkpoint.

  4. RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast

    Energy Technology Data Exchange (ETDEWEB)

    Iida, Tetsushi, E-mail: tiida@nig.ac.jp [Division of Cytogenetics, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); The Graduate University for Advanced Studies, Sokendai, Mishima, 1111 Yata, Mishima 411-8540 (Japan); Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), 4-1-8, Honcho, Kawaguchi-shi, Saitama 332-0012 (Japan); Iida, Naoko [Division of Mutagenesis, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); Tsutsui, Yasuhiro [Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuda-cho, Midori-ku, Yokohama 226-8501 (Japan); Yamao, Fumiaki [Division of Mutagenesis, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); The Graduate University for Advanced Studies, Sokendai, Mishima, 1111 Yata, Mishima 411-8540 (Japan); Kobayashi, Takehiko [Division of Cytogenetics, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); The Graduate University for Advanced Studies, Sokendai, Mishima, 1111 Yata, Mishima 411-8540 (Japan)

    2012-10-12

    Highlights: Black-Right-Pointing-Pointer RNAi is linked to the cell cycle checkpoint in fission yeast. Black-Right-Pointing-Pointer Ptr1 co-purifies with Ago1. Black-Right-Pointing-Pointer The ptr1-1 mutation impairs the checkpoint but does not affect gene silencing. Black-Right-Pointing-Pointer ago1{sup +} and ptr1{sup +} regulate the cell cycle checkpoint via the same pathway. Black-Right-Pointing-Pointer Mutations in ago1{sup +} and ptr1{sup +} lead to the nuclear accumulation of poly(A){sup +} RNAs. -- Abstract: Ago1, an effector protein of RNA interference (RNAi), regulates heterochromatin silencing and cell cycle arrest in fission yeast. However, the mechanism by which Ago1 controls cell cycle checkpoint following hydroxyurea (HU) treatment has not been elucidated. In this study, we show that Ago1 and other RNAi factors control cell cycle checkpoint following HU treatment via a mechanism independent of silencing. While silencing requires dcr1{sup +}, the overexpression of ago1{sup +} alleviated the cell cycle defect in dcr1{Delta}. Ago1 interacted with the mRNA export factor, Ptr1. The ptr1-1 mutation impaired cell cycle checkpoint but gene silencing was unaffected. Genetic analysis revealed that the regulation of cell cycle checkpoint by ago1{sup +} is dependent on ptr1{sup +}. Nuclear accumulation of poly(A){sup +} RNAs was detected in mutants of ago1{sup +} and ptr1{sup +}, suggesting there is a functional link between the cell cycle checkpoint and RNAi-mediated RNA quality control.

  5. Health care utilization by immigrants in Italy.

    Science.gov (United States)

    De Luca, Giuliana; Ponzo, Michela; Andrés, Antonio Rodríguez

    2013-03-01

    Healthcare utilization studies show how well documented disparities between migrants and non-migrants. Reducing such disparities is a major goal in European countries. However, healthcare utilization among Italian immigrants is under-studied. The objective of this study is to explore differences in healthcare use between immigrant and native Italians. Cross-sectional study using the latest available (2004/2005) Italian Health Conditions Survey. We estimated separate hurdle binomial negative regression models for GP, specialist, and telephone consultations and a logit model for emergency room (ER) use. We used logistic regression and zero-truncated negative binomial regression to model the zero (contact decision) and count processes (frequency decisions) respectively. Adjusting for risk factors, immigrants are significantly less likely to use healthcare services with 2.4 and 2.7 % lower utilization probability for specialist and telephone consultations, respectively. First- and second-generation immigrants' probability for specialist and telephone contact is significantly lower than natives'. Immigrants, ceteris paribus, have a much higher probability of using ERs than natives (0.7 %). First-generation immigrants show a higher probability of visiting ERs (1 %). GP visits show no significant difference. In conclusion Italian immigrants are much less likely to use specialist healthcare and medical telephone consultations than natives but more likely to use ERs. Hence, we report an over-use of ERs and under-utilization of preventive care among immigrants. We recommend improved health policies for immigrants: promotion of better information dissemination among them, simplification of organizational procedures, better communications between providers and immigrants, and an increased supply of health services for the most disadvantaged populations. PMID:23239018

  6. Europeanisation of national immigration policies

    OpenAIRE

    Saltik, Serkan

    2015-01-01

    The ‘ever closer union’ motto of the 1957 Rome Treaty was indeed one of the most assertive ‘superordinate goals’ in the history of the EU. Symbolic as it may sound, a formulation of this sort was in the aftermath of a war-stricken Europe intending to promote the initial cooperation between a number of formerly hostile states to a broader audience. For immigration issues, as part of a diverse range of policy areas in the Community’s course of action to that effect, the Schengen Treaties in the...

  7. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis.

    Science.gov (United States)

    Dubin, Krista; Callahan, Margaret K; Ren, Boyu; Khanin, Raya; Viale, Agnes; Ling, Lilan; No, Daniel; Gobourne, Asia; Littmann, Eric; Huttenhower, Curtis; Pamer, Eric G; Wolchok, Jedd D

    2016-01-01

    The composition of the intestinal microbiota influences the development of inflammatory disorders. However, associating inflammatory diseases with specific microbial members of the microbiota is challenging, because clinically detectable inflammation and its treatment can alter the microbiota's composition. Immunologic checkpoint blockade with ipilimumab, a monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) signalling, is associated with new-onset, immune-mediated colitis. Here we conduct a prospective study of patients with metastatic melanoma undergoing ipilimumab treatment and correlate the pre-inflammation faecal microbiota and microbiome composition with subsequent colitis development. We demonstrate that increased representation of bacteria belonging to the Bacteroidetes phylum is correlated with resistance to the development of checkpoint-blockade-induced colitis. Furthermore, a paucity of genetic pathways involved in polyamine transport and B vitamin biosynthesis is associated with an increased risk of colitis. Identification of these biomarkers may enable interventions to reduce the risk of inflammatory complications following cancer immunotherapy. PMID:26837003

  8. Social and ethical checkpoints for bottom-up synthetic biology, or protocells.

    Science.gov (United States)

    Bedau, Mark A; Parke, Emily C; Tangen, Uwe; Hantsche-Tangen, Brigitte

    2009-12-01

    An alternative to creating novel organisms through the traditional "top-down" approach to synthetic biology involves creating them from the "bottom up" by assembling them from non-living components; the products of this approach are called "protocells." In this paper we describe how bottom-up and top-down synthetic biology differ, review the current state of protocell research and development, and examine the unique ethical, social, and regulatory issues raised by bottom-up synthetic biology. Protocells have not yet been developed, but many expect this to happen within the next five to ten years. Accordingly, we identify six key checkpoints in protocell development at which particular attention should be given to specific ethical, social and regulatory issues concerning bottom-up synthetic biology, and make ten recommendations for responsible protocell science that are tied to the achievement of these checkpoints. PMID:19816801

  9. An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer

    Science.gov (United States)

    Teixeira, José Henrique; Silva, Patrícia Manuela; Reis, Rita Margarida; Moura, Inês Moranguinho; Marques, Sandra; Fonseca, Joana; Monteiro, Luís Silva; Bousbaa, Hassan

    2014-01-01

    Abnormal chromosome number, or aneuploidy, is a common feature of human solid tumors, including oral cancer. Deregulated spindle assembly checkpoint (SAC) is thought as one of the mechanisms that drive aneuploidy. In normal cells, SAC prevents anaphase onset until all chromosomes are correctly aligned at the metaphase plate thereby ensuring genomic stability. Significantly, the activity of this checkpoint is compromised in many cancers. While mutations are rather rare, many tumors show altered expression levels of SAC components. Genomic alterations such as aneuploidy indicate a high risk of oral cancer and cancer-related mortality, and the molecular basis of these alterations is largely unknown. Yet, our knowledge on the status of SAC components in oral cancer remains sparse. In this review, we address the state of our knowledge regarding the SAC defects and the underlying molecular mechanisms in oral cancer, and discuss their therapeutic relevance, focusing our analysis on the core components of SAC and its target Cdc20. PMID:24995269

  10. Cloud object store for checkpoints of high performance computing applications using decoupling middleware

    Energy Technology Data Exchange (ETDEWEB)

    Bent, John M.; Faibish, Sorin; Grider, Gary

    2016-04-19

    Cloud object storage is enabled for checkpoints of high performance computing applications using a middleware process. A plurality of files, such as checkpoint files, generated by a plurality of processes in a parallel computing system are stored by obtaining said plurality of files from said parallel computing system; converting said plurality of files to objects using a log structured file system middleware process; and providing said objects for storage in a cloud object storage system. The plurality of processes may run, for example, on a plurality of compute nodes. The log structured file system middleware process may be embodied, for example, as a Parallel Log-Structured File System (PLFS). The log structured file system middleware process optionally executes on a burst buffer node.

  11. The Integration of Immigrant Families in the United States.

    Science.gov (United States)

    Fix, Michael; Zimmermann, Wendy; Passel, Jeffrey S.

    This paper examines the assimilation of immigrant families in the United States. Chapter 1, "Introduction," reviews basic issues. Chapter 2, "Why Discuss the Integration of Immigrant Families?" examines such issues as continuing mismatches between immigration and immigrant policies, population dispersal, the shifting political climate, and policy…

  12. Facing Our Future: Children in the Aftermath of Immigration Enforcement

    Science.gov (United States)

    Chaudry, Ajay; Capps, Randy; Pedroza, Juan Manuel; Castaneda, Rosa Maria; Santos, Robert; Scott, Molly M.

    2010-01-01

    The United States is engaged in an intense debate about immigration policy, particularly with regard to unauthorized immigrants. Debates rage about the economic contributions of immigrants to the U.S. economy, job competition, tax payments and fiscal costs, and the integration of immigrants in communities and the larger society. Largely absent…

  13. Culturally Responsive Leadership: Best Practice in Integrating Immigrant Students

    Science.gov (United States)

    Magno, Cathyrn; Schiff, Margo

    2010-01-01

    Immigration to the US has fluctuated with economic conditions and with American immigration policies. Historically, most immigrants settled in urban areas, while suburban towns and their schools remained almost completely homogeneous and overwhelmingly White. Today, roughly one in five children in the US comes from an immigrant home, altering the…

  14. 28 CFR 0.117 - Office of Chief Immigration Judge.

    Science.gov (United States)

    2010-07-01

    ... accordance with the Immigration and Nationality Act, 8 U.S.C. 1226 and 1252 and 8 CFR 3.9. ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Office of Chief Immigration Judge. 0.117... Executive Office for Immigration Review § 0.117 Office of Chief Immigration Judge. The Chief...

  15. 8 CFR 1235.6 - Referral to immigration judge.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Referral to immigration judge. 1235.6 Section 1235.6 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS INSPECTION OF PERSONS APPLYING FOR ADMISSION § 1235.6 Referral to immigration...

  16. Credible Immigration Policy Reform: A Response to Briggs

    Science.gov (United States)

    Orrenius, Pia M.; Zavodny, Madeline

    2012-01-01

    The authors agree with Vernon M. Briggs, Jr., that U.S. immigration policy has had unexpected consequences. The 1965 immigration reforms led to unanticipated chain migration from developing countries whereas the 1986 Immigration Reform and Control Act failed to slow unauthorized immigration. The result is a large foreign-born population with…

  17. 8 CFR 1003.11 - Administrative control Immigration Courts.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Administrative control Immigration Courts. 1003.11 Section 1003.11 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Office of the Chief Immigration...

  18. Immigration and Ethnic Communities: A Focus on Latinos.

    Science.gov (United States)

    Rochin, Refugio I., Ed.

    For over a decade, Latino immigrants, especially those of Mexican origin, have been at the heart of the immigration debate and have borne the brunt of conservative populism. Contributing factors to the public reaction to immigrants in general and Latinos specifically include the sheer size of recent immigration, the increasing prevalence of…

  19. Skill-based immigration, economic integration, and economic performance

    OpenAIRE

    Aydemir, Abdurrahman

    2014-01-01

    Studies for major immigrant-receiving countries provide evidence on the comparative economic performance of immigrant classes (skill-, kinship-, and humanitarian-based). Developed countries are increasingly competing for high-skilled immigrants, who perform better in the labor market. However, there are serious challenges to their economic integration, which highlights a need for complementary immigration and integration policies.

  20. Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint.

    Directory of Open Access Journals (Sweden)

    Sagar P Mahale

    Full Text Available The multi-functional molecular motor cytoplasmic dynein performs diverse essential roles during mitosis. The mechanistic importance of the dynein Light Intermediate Chain homologs, LIC1 and LIC2 is unappreciated, especially in the context of mitosis. LIC1 and LIC2 are believed to exist in distinct cytoplasmic dynein complexes as obligate subunits. LIC1 had earlier been reported to be required for metaphase to anaphase progression by inactivating the kinetochore-microtubule attachment-sensing arm of the spindle assembly checkpoint (SAC. However, the functional importance of LIC2 during mitosis remains elusive. Here we report prominent novel roles for the LIC2 subunit of cytoplasmic dynein in regulating the spindle assembly checkpoint. LIC2 depletion in mammalian cells led to prolonged metaphase arrest in the presence of an active SAC and also to stretched kinetochores, thus implicating it in SAC inactivation. Quantitative fluorescence microscopy of SAC components revealed accumulation of both attachment- and tension-sensing checkpoint proteins at metaphase kinetochores upon LIC2 depletion. These observations support a stronger and more diverse role in checkpoint inactivation for LIC2 in comparison to its close homolog LIC1. Our study uncovers a novel functional hierarchy during mitotic checkpoint inactivation between the closely related but homologous LIC subunits of cytoplasmic dynein. These subtle functional distinctions between dynein subpopulations could be exploited to study specific aspects of the spindle assembly checkpoint, which is a key mediator of fidelity in eukaryotic cell division.

  1. Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks

    International Nuclear Information System (INIS)

    Highlights: • Inhibition of Src family kinases decreased γ-H2AX signal. • Inhibition of Src family increased ATM-dependent phosphorylation of Chk2 and Kap1. • shRNA-mediated knockdown of Lyn increased phosphorylation of Kap1 by ATM. • Ectopic expression of Src family kinase suppressed ATM-mediated Kap1 phosphorylation. • Src is involved in upstream signaling for inactivation of ATM signaling. - Abstract: DNA damage activates the DNA damage checkpoint and the DNA repair machinery. After initial activation of DNA damage responses, cells recover to their original states through completion of DNA repair and termination of checkpoint signaling. Currently, little is known about the process by which cells recover from the DNA damage checkpoint, a process called checkpoint recovery. Here, we show that Src family kinases promote inactivation of ataxia telangiectasia mutated (ATM)-dependent checkpoint signaling during recovery from DNA double-strand breaks. Inhibition of Src activity increased ATM-dependent phosphorylation of Chk2 and Kap1. Src inhibition increased ATM signaling both in G2 phase and during asynchronous growth. shRNA knockdown of Lyn increased ATM signaling. Src-dependent nuclear tyrosine phosphorylation suppressed ATM-mediated Kap1 phosphorylation. These results suggest that Src family kinases are involved in upstream signaling that leads to inactivation of the ATM-dependent DNA damage checkpoint

  2. Differential activation of intra-S-phase checkpoint in response to tripchlorolide and its effects on DNA replication

    Institute of Scientific and Technical Information of China (English)

    Yan REN; Jia Rui WU

    2004-01-01

    DNA replication is tightly regulated during the S phase of the cell cycle, and the activation of the intra-S-phase checkpoint due to DNA damage usually results in arrest of DNA synthesis. However, the molecular details about the correlation between the checkpoint and regulation of DNA replication are still unclear. To investigate the connections between DNA replication and DNA damage checkpoint, a DNA-damage reagent, tripchlorolide, was applied to CHO (Chinese ovary hamster) cells at early- or middle-stages of the S phase. The early-S-phase treatment with TC significantly delayed the progression of the S phase and caused the phosphorylation of the Chk1 checkpoint protein, whereas the middle-S-phase treatment only slightly slowed down the progression of the S phase. Furthermore, the analysis of DNA replication patterns revealed that replication pattern Ⅱ was greatly prolonged in the cells treated with the drug during the early-S phase, whereas the late-replication patterns of these cells were hardly detected, suggesting that the activation of the intra-S-phase checkpoint inhibits the late-origin firing of DNA replication. We conclude that cells at different stages of the S phase are differentially sensitive to the DNA-damage reagent, and the activation of the intra-Sphase checkpoint blocks the DNA replication progression in the late stage of S phase.

  3. Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint

    Science.gov (United States)

    Mahale, Sagar P.; Sharma, Amit; Mylavarapu, Sivaram V. S.

    2016-01-01

    The multi-functional molecular motor cytoplasmic dynein performs diverse essential roles during mitosis. The mechanistic importance of the dynein Light Intermediate Chain homologs, LIC1 and LIC2 is unappreciated, especially in the context of mitosis. LIC1 and LIC2 are believed to exist in distinct cytoplasmic dynein complexes as obligate subunits. LIC1 had earlier been reported to be required for metaphase to anaphase progression by inactivating the kinetochore-microtubule attachment-sensing arm of the spindle assembly checkpoint (SAC). However, the functional importance of LIC2 during mitosis remains elusive. Here we report prominent novel roles for the LIC2 subunit of cytoplasmic dynein in regulating the spindle assembly checkpoint. LIC2 depletion in mammalian cells led to prolonged metaphase arrest in the presence of an active SAC and also to stretched kinetochores, thus implicating it in SAC inactivation. Quantitative fluorescence microscopy of SAC components revealed accumulation of both attachment- and tension-sensing checkpoint proteins at metaphase kinetochores upon LIC2 depletion. These observations support a stronger and more diverse role in checkpoint inactivation for LIC2 in comparison to its close homolog LIC1. Our study uncovers a novel functional hierarchy during mitotic checkpoint inactivation between the closely related but homologous LIC subunits of cytoplasmic dynein. These subtle functional distinctions between dynein subpopulations could be exploited to study specific aspects of the spindle assembly checkpoint, which is a key mediator of fidelity in eukaryotic cell division. PMID:27441562

  4. Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks

    Energy Technology Data Exchange (ETDEWEB)

    Fukumoto, Yasunori, E-mail: fukumoto@faculty.chiba-u.jp; Kuki, Kazumasa; Morii, Mariko; Miura, Takahito; Honda, Takuya; Ishibashi, Kenichi; Hasegawa, Hitomi; Kubota, Sho; Ide, Yudai; Yamaguchi, Noritaka; Nakayama, Yuji; Yamaguchi, Naoto, E-mail: nyama@faculty.chiba-u.jp

    2014-09-26

    Highlights: • Inhibition of Src family kinases decreased γ-H2AX signal. • Inhibition of Src family increased ATM-dependent phosphorylation of Chk2 and Kap1. • shRNA-mediated knockdown of Lyn increased phosphorylation of Kap1 by ATM. • Ectopic expression of Src family kinase suppressed ATM-mediated Kap1 phosphorylation. • Src is involved in upstream signaling for inactivation of ATM signaling. - Abstract: DNA damage activates the DNA damage checkpoint and the DNA repair machinery. After initial activation of DNA damage responses, cells recover to their original states through completion of DNA repair and termination of checkpoint signaling. Currently, little is known about the process by which cells recover from the DNA damage checkpoint, a process called checkpoint recovery. Here, we show that Src family kinases promote inactivation of ataxia telangiectasia mutated (ATM)-dependent checkpoint signaling during recovery from DNA double-strand breaks. Inhibition of Src activity increased ATM-dependent phosphorylation of Chk2 and Kap1. Src inhibition increased ATM signaling both in G2 phase and during asynchronous growth. shRNA knockdown of Lyn increased ATM signaling. Src-dependent nuclear tyrosine phosphorylation suppressed ATM-mediated Kap1 phosphorylation. These results suggest that Src family kinases are involved in upstream signaling that leads to inactivation of the ATM-dependent DNA damage checkpoint.

  5. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

    OpenAIRE

    Dubin, Krista; Callahan, Margaret K.; Ren, Boyu; Khanin, Raya; Viale, Agnes; Ling, Lilan; No, Daniel; Gobourne, Asia; Littmann, Eric; Huttenhower, Curtis; Pamer, Eric G.; Wolchok, Jedd D.

    2016-01-01

    The composition of the intestinal microbiota influences the development of inflammatory disorders. However, associating inflammatory diseases with specific microbial members of the microbiota is challenging, because clinically detectable inflammation and its treatment can alter the microbiota's composition. Immunologic checkpoint blockade with ipilimumab, a monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) signalling, is associated with new-onset, immune-med...

  6. CDC28, NETI, and HFII are required for checkpoints in Saccharomyces cerevisiae

    International Nuclear Information System (INIS)

    The involvement of SRM genes selected as genes affecting genetic stability and radiosensitivity in a cell cycle arrest under the action of damaging agents was studied. It was shown that the srm5/cdc28-srm, srm8/netI-srm, and srmI2/hfiI-srm mutations prevent checkpoint activation by DNA damage, particularly the G0/S (srm5, srm8), G1/S (srm5, srm8, srm12), S (srm8, srm12) and S/G2 (srm5) checkpoints. It seems that in budding yeast the CDC28, HFII/ADAI, and NETI genes mediate cellular response induced by DNA damage with checkpoint control. The well-known checkpoint-genes RAD9, RAD17, RAD24, and RAD53, and the genes CDC28, and NETI have been found to belong to one epistasis group named RAD9-group as regards cell sensitivity to γ radiation. An analysis of the radiosensitivity of double mutants has revealed that the mutation cdc-28-srm is hypostatic to each of mutations rad9Δ, and rad24Δ, and additive to rad17Δ. The mutation netI-srm is hypostatic to the mutations rad9Δ but additive to rad17Δ, rad24Δ, and rad53. The mutation hfiI-srm has an additive effect in compound with the mutations rad24Δ and rad9Δ. So, investigations of epistatic interactions have demonstrated a branched RAD9-dependent pathway. The analyzed genes can also participate in a minor mechanism involved in determining cell radiation sensitivity independently of the mentioned RAD9-dependent pathway

  7. Handoff Based Secure Checkpointing and Log Based Rollback Recovery for Mobile Hosts

    Directory of Open Access Journals (Sweden)

    Priyanka Dey and Suparna Biswas

    2012-10-01

    Full Text Available An efficient fault tolerant algorithm based on movement-based secure checkpointing and logging formobile computing system is proposed here. The recovery scheme proposed here combines independentcheckpointing and message logging. Here we consider mobility rate of the user in checkpointing so thatmobile host can manage recovery information such as checkpoints and logs properly so that a mobilehost takes less recovery time after failure. Mobile hosts save checkpoints when number of hand-offexceeds a predefined hand-off threshold value. Current approaches save logs in base station. But thisapproach maximizes recovery time if message passing frequency is large. If a mobile host saves log in itsown memory, recovery cost will be less because log retrieval time will be small after failure. But there isa probability of memory crash of a mobile host. In that case logs can not be retrieved if it is saved only inmobile node. If the failure is transient then logs can be retrieved from the memory of mobile node.Hence in this algorithm mobile hosts also save log in own memory and base station. In case of crashrecovery, log will be retrieved from base station and in case of transient failure recovery logs will beretrieved from mobile host. In this algorithm recovery probability is optimized and total recovery time isreduced in comparison to existing works. Logs are very small in size. Hence saving logs in mobile hostsdoes not cause much memory overhead. Hand-off threshold is a function of mobility rate, messagepassing frequency and failure rate of mobile hosts. This algorithm describes a secure check pointingtechnique as a method for providing fault tolerance while preventing information leakage through thecheckpoint data.

  8. Sudden Telomere Lengthening Triggers a Rad53-dependent Checkpoint in Saccharomyces cerevisiae

    OpenAIRE

    Viscardi, Valeria; Baroni, Enrico; Romano, Michele; Lucchini, Giovanna; Longhese, Maria Pia

    2003-01-01

    Telomeres are specialized functional complexes that ensure chromosome stability by protecting chromosome ends from fusions and degradation and avoiding chromosomal termini from being sensed as DNA breaks. Budding yeast Tel1 is required both for telomere metabolism and for a Rad53-dependent checkpoint responding to unprocessed double-strand breaks. We show that overexpression of a GAL1-TEL1 fusion causes transient telomere lengthening and activation of a Rad53-dependent...

  9. In vivo role of checkpoint kinase 2 in signaling telomere dysfunction

    OpenAIRE

    García-Beccaria, María; Martínez, Paula; Flores, Juana M.; Blasco, Maria A.

    2014-01-01

    Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis. Successive generations of telomerase-deficient (Terc) mice show accelerated aging and shorter lifespan due to tissue atrophy and impaired organ regeneration associated to progressive telomere shortening. In contrast, m...

  10. Cdk2 is required for p53-independent G2/M checkpoint control.

    Directory of Open Access Journals (Sweden)

    Jon H Chung

    2010-02-01

    Full Text Available The activation of phase-specific cyclin-dependent kinases (Cdks is associated with ordered cell cycle transitions. Among the mammalian Cdks, only Cdk1 is essential for somatic cell proliferation. Cdk1 can apparently substitute for Cdk2, Cdk4, and Cdk6, which are individually dispensable in mice. It is unclear if all functions of non-essential Cdks are fully redundant with Cdk1. Using a genetic approach, we show that Cdk2, the S-phase Cdk, uniquely controls the G(2/M checkpoint that prevents cells with damaged DNA from initiating mitosis. CDK2-nullizygous human cells exposed to ionizing radiation failed to exclude Cdk1 from the nucleus and exhibited a marked defect in G(2/M arrest that was unmasked by the disruption of P53. The DNA replication licensing protein Cdc6, which is normally stabilized by Cdk2, was physically associated with the checkpoint regulator ATR and was required for efficient ATR-Chk1-Cdc25A signaling. These findings demonstrate that Cdk2 maintains a balance of S-phase regulatory proteins and thereby coordinates subsequent p53-independent G(2/M checkpoint activation.

  11. Biological significance of the focus on DNA damage checkpoint factors remained after irradiation of ionizing radiation

    International Nuclear Information System (INIS)

    This paper reviews recent reports on the focus formation and participation to checkpoint of (such phosphorylated (P-d) as below) ATM and H2AX, MDC1, 53BP1 and NBS1, and discusses their role in DNA damage checkpoint induction mainly around authors' studies. When the cell is irradiated by ionizing radiation, the subtype histone like H2AX is P-d and the formed focus', seen in the nucleus on immuno-fluorographic observation, represents the P-d H2AX at the damaged site of DNA. The role of P-d ATM (the product of causative gene of ataxia-telangiectasia mutation, a protein kinase) has been first shown by laser beam irradiation. Described are discussions on the roles and functions after irradiation in focus formation and DNA damage checkpoint of P-d H2AX (a specific histone product by the radiation like γ-ray as above), P-d ATM, MDC1 (a mediator of DNA damage check point protein 1), 53BP1, (a p53 binding protein) and NBS1 (the product of the causative gene of Nijmegen Breakage Syndrome). Authors have come to point out the remained focal size increase as implications of the efficient repair of damaged DNA, and the second cycled p53 accumulation, of tumor suppression. Thus evaluation of biological significance of these aspects, scarcely noted hitherto, is concluded important. (S.I.)

  12. Efficient checkpointing schemes for depletion perturbation solutions on memory-limited architectures

    International Nuclear Information System (INIS)

    We describe a methodology for decreasing the memory footprint and machine I/O load associated with the need to access a forward solution during an adjoint solve. Specifically, we are interested in the depletion perturbation equations, where terms in the adjoint Bateman and transport equations depend on the forward flux solution. Checkpointing is the procedure of storing snapshots of the forward solution to disk and using these snapshots to recompute the parts of the forward solution that are necessary for the adjoint solve. For large problems, however, the storage cost of just a few copies of an angular flux vector can exceed the available RAM on the host machine. We propose a methodology that does not checkpoint the angular flux vector; instead, we write and store converged source moments, which are typically of a much lower dimension than the angular flux solution. This reduces the memory footprint and I/O load of the problem, but requires that we perform single sweeps to reconstruct flux vectors on demand. We argue that this trade-off is exactly the kind of algorithm that will scale on advanced, memory-limited architectures. We analyze the cost, in terms of FLOPS and memory footprint, of five checkpointing schemes. We also provide computational results that support the analysis and show that the memory-for-work trade off does improve time to solution. (authors)

  13. Efficient checkpointing schemes for depletion perturbation solutions on memory-limited architectures

    Energy Technology Data Exchange (ETDEWEB)

    Stripling, H. F.; Adams, M. L.; Hawkins, W. D. [Texas A and M University, Department of Nuclear Engineering, 3133 TAMU, College Station, TX 77843-3133 (United States)

    2013-07-01

    We describe a methodology for decreasing the memory footprint and machine I/O load associated with the need to access a forward solution during an adjoint solve. Specifically, we are interested in the depletion perturbation equations, where terms in the adjoint Bateman and transport equations depend on the forward flux solution. Checkpointing is the procedure of storing snapshots of the forward solution to disk and using these snapshots to recompute the parts of the forward solution that are necessary for the adjoint solve. For large problems, however, the storage cost of just a few copies of an angular flux vector can exceed the available RAM on the host machine. We propose a methodology that does not checkpoint the angular flux vector; instead, we write and store converged source moments, which are typically of a much lower dimension than the angular flux solution. This reduces the memory footprint and I/O load of the problem, but requires that we perform single sweeps to reconstruct flux vectors on demand. We argue that this trade-off is exactly the kind of algorithm that will scale on advanced, memory-limited architectures. We analyze the cost, in terms of FLOPS and memory footprint, of five checkpointing schemes. We also provide computational results that support the analysis and show that the memory-for-work trade off does improve time to solution. (authors)

  14. Immune checkpoint blockade therapy: The 2014 Tang prize in biopharmaceutical science

    Directory of Open Access Journals (Sweden)

    Ya-Shan Chen

    2015-02-01

    Full Text Available The first Tang Prize for Biopharmaceutical Science has been awarded to Prof. James P. Allison and Prof. Tasuku Honjo for their contributions leading to an entirely new way to treat cancer by blocking the molecules cytotoxic T lymphocyte-associated antigen 4 (CTLA-4 and programmed cell death protein 1 (PD-1 that turn off immune response. The treatment, called "immune checkpoint blockade therapy," has opened a new therapeutic era. Here the discoveries of the immune checkpoints and how they contribute to the maintenance of self-tolerance, as well as how to protect tissues from the excess immune responses causing damage are reviewed. The efforts made by Prof. Allison and Prof. Honjo for developing the most promising approaches to activate therapeutic antitumor immunity are also summarized. Since these certain immune checkpoint pathways appear to be one of the major mechanisms resulting in immune escape of tumors, the presence of anti-CTLA-4 and/or anti-PD-1 should contribute to removal of the inhibition signals for T cell activation. Subsequently, it will enhance specific T cell activation and, therefore, strengthen antitumor immunity.

  15. Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1 receptor pathway

    Directory of Open Access Journals (Sweden)

    Momtaz P

    2014-11-01

    Full Text Available Parisa Momtaz,1,2 Michael A Postow1,2 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; 2Weill Cornell Medical College, New York, NY, USA Abstract: T-lymphocytes have the potential to recognize cancer antigens as foreign and therefore eliminate them. However, immune checkpoints such as cytotoxic T-lymphocyte-associated antigen (CTLA-4 and programmed cell death (PD-1 receptor and its ligands (PD-L1, PD-L2 suppress the activity of T-lymphocytes. Advances in the understanding of immunology and its role in cancer have led to the development of immune checkpoint inhibitors that block CTLA-4 and PD-1 and result in durable responses in patients with a wide range of cancers. PD-1 and PD-L1 inhibitors are currently in many stages of clinical investigation, and the anti-PD-1 antibody, pembrolizumab, was recently approved by the US Food and Drug Administration. Many questions remain to be answered, such as the optimal administration schedule, biomarkers that associate with benefit, and potential for use of PD-1 agents in combination approaches. Nonetheless, immunotherapy with PD-1 blocking antibodies is now becoming an integral part in the management of cancer. Keyword: immune checkpoints, immunotherapy, programmed cell death protein-1, cytotoxic T-lymphocyte antigen 4

  16. Eavesdropping on the cytoskeleton: progress and controversy in the yeast morphogenesis checkpoint.

    Science.gov (United States)

    Keaton, Mignon A; Lew, Daniel J

    2006-12-01

    The morphogenesis checkpoint provides a link between bud formation and mitosis in yeast. In this pathway, insults affecting the actin or septin cytoskeleton trigger a cell cycle arrest, mediated by the Wee1 homolog Swe1p, which catalyzes the inhibitory phosphorylation of the mitosis-promoting cyclin-dependent kinase (CDK) on a conserved tyrosine residue. Analyses of Swe1p phosphorylation have mapped 61 sites targeted by CDKs and Polo-related kinases, which control both Swe1p activity and Swe1p degradation. Although the sites themselves are not evolutionarily conserved, the control of Swe1p degradation exhibits many conserved features, and is linked to DNA-responsive checkpoints in vertebrate cells. At the 'sensing' end of the checkpoint, recent work has begun to shed light on how septins are organized and how they impact Swe1p regulators. However, the means by which Swe1p responds to actin perturbations once a bud has formed remains controversial. PMID:17055334

  17. Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D

    International Nuclear Information System (INIS)

    MultiCellular Tumor Spheroid (MCTS) mimics the organization of a tumor and is considered as an invaluable model to study cancer cell biology and to evaluate new antiproliferative drugs. Here we report how the characteristics of MCTS in association with new technological developments can be used to explore the regionalization and the activation of cell cycle checkpoints in 3D. Cell cycle and proliferation parameters were investigated in Capan-2 spheroids by immunofluorescence staining, EdU incorporation and using cells engineered to express Fucci-red and -green reporters. We describe in details the changes in proliferation and cell cycle parameters during spheroid growth and regionalization. We report the kinetics and regionalized aspects of cell cycle arrest in response to checkpoint activation induced by EGF starvation, lovastatin treatment and etoposide-induced DNA damage. Our data present the power and the limitation of spheroids made of genetically modified cells to explore cell cycle checkpoints. This study paves the way for the investigation of molecular aspects and dynamic studies of the response to novel antiproliferative agents in 3D models

  18. RNF8 Transduces the DNA-Damage Signal Via Histone Ubiquitylation And Checkpoint Protein Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Huen, M.S.Y.; Grant, R.; Manke, I.; Minn, K.; Yu, X.; Yaffe, M.B.; Chen, J.

    2009-06-01

    DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches to regulate cell-cycle checkpoints, DNA repair, cellular senescence, and apoptosis. Here we show that RNF8, a FHA/RING domain-containing protein, plays a critical role in the early DNA-damage response. We have solved the X-ray crystal structure of the FHA domain structure at 1.35 {angstrom}. We have shown that RNF8 facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 to the damaged chromatin, on one hand through the phospho-dependent FHA domain-mediated binding of RNF8 to MDC1, on the other hand via its role in ubiquitylating H2AX and possibly other substrates at damage sites. Moreover, RNF8-depleted cells displayed a defective G2/M checkpoint and increased IR sensitivity. Together, our study implicates RNF8 as a novel DNA-damage-responsive protein that integrates protein phosphorylation and ubiquitylation signaling and plays a critical role in the cellular response to genotoxic stress.

  19. Cultural Clash and Educational Diversity: Immigrant Teachers' Efforts To Rescue the Education of Immigrant Children in Israel.

    Science.gov (United States)

    Epstein, Alek D.; Kheimets, Nina G.

    2000-01-01

    Presents the results of a study on the Mofet system (Israel), founded by immigrant teachers in 1991 as an effort to educate Russian immigrant children. Argues that although the success of the system is linked to the general education system's failure to meet immigrants' needs, it does not express Russian immigrant's desire for socio-cultural…

  20. Pre-school enrollment: an analysis by immigrant generation

    OpenAIRE

    Barry R. Chiswick; DebBurman, Noyna

    2004-01-01

    There has been minimal research on the pre-school enrollment of immigrant children. Using 1990 U.S. Census data, this paper investigates pre-school enrollment of child immigrants, those who immigrated as children and the U.S.-born children of immigrants. The analysis is conducted using probit analysis. Pre-school enrollment is found to vary systematically with parental characteristics (income and education), immigrant generation, number of siblings, mother's labor supply and country of origin...

  1. The economie impact of immigration for the host countries

    OpenAIRE

    Chojnicki, Xavier

    2004-01-01

    In this paper, we will investigate the economic consequences of immigration for the host countries. Recently, the debate has been centered on the role of immigration in the process of aging. A priori, the immigration of workers is likely to affect the economic situation of the host country in multiple ways, both positive and negative. Most studies focused on the labor market reveal a weak net gain of immigration whose distribution depends on the skill structure of immigrants and domestic labo...

  2. Host National Identification of Immigrants in the Netherlands

    OpenAIRE

    de Vroome, Thomas; Verkuyten, Maykel; Martinovic, Borja

    2014-01-01

    This study examines immigrants' identification with the host country. We use survey data of more than 1,700 Turkish and Moroccan immigrants and more than 2,200 natives in the Netherlands. We answer four main questions in this study. First, do immigrants have lower national identification than natives? Second, does the level of national identification differ between immigrant groups? Third, do economic and social integration similarly affect national identification among immigrants and natives...

  3. Immigrant-Native Substitutability: The Role of Language Ability

    OpenAIRE

    Ethan G. Lewis

    2011-01-01

    Wage evidence suggests that immigrant workers are imperfectly substitutable for native-born workers with similar education and experience. Using U.S. Censuses and recent American Community Survey data, I ask to what extent differences in language skills drive this. I find they are important. I estimate that the response of immigrants' relative wages to immigration is concentrated among immigrants with poor English skills. Similarly, immigrants who arrive at young ages, as adults, both have st...

  4. Immigrant quality and assimilation: A review of the US literature

    OpenAIRE

    T. Paul Schultz

    1998-01-01

    Empirical research on US immigrants is reviewed: their productivity and assimilation; their contribution and use of public services; and their impact on native Americans. I discuss the characteristics of cohorts of immigrants that enter the United States at different times, and then quantify the assimilation of immigrants, typically in terms of economic productivity of immigrants compared with natives. Few have found quantifiable negative effects of immigrants on native wages or unemployment ...

  5. Integration and immigration pressures in western Europe.

    Science.gov (United States)

    Bohning, W R

    1991-01-01

    "With xenophobia resurgent in Europe, this article addresses some of the complexities of immigration and integration in EC [European Community] and EFTA [European Free Trade Association] countries. The categories of legal and illegal immigrants (including estimates thereof) are first described, as are the necessary ingredients of an integration policy (a framework law, a secure environment, cultural tolerance, demarginalization in housing and the labour market). The author then considers what types of action would help to ease the present immigration pressure, discussing in turn quota policies, project-tied or training migration and, finally, the use of international aid." PMID:12317134

  6. Illegal Immigration and the Shadow Economy

    OpenAIRE

    Camacho, Carmen; Mariani, Fabio; Pensieroso, Luca

    2015-01-01

    We build a general equilibrium model in which both illegal immigration and the size of the informal sector are endogenously determined and interact in a non-trivial way. We show that policy measures such as tax reduction and detection of informal activities can be used as substitutes for border enforcement, in order to contrast illegal immigration. In our framework, a welfare-maximising Government will never choose to drive illegal immigration to zero, but will set the tax rate to a lower val...

  7. Illegal aliens, unemployment and immigration policy.

    Science.gov (United States)

    Djajic, S

    1987-02-01

    "This paper develops a simple two-country model of illegal immigration in an attempt to examine the interaction among variables such as the stock of migrant labor, the unemployment rates of the two economies, and the rate of spending by the host country on the enforcement of its immigration restrictions. The focus of the analysis is on the dynamics of immigration policy and on its role in determining the nature of the mechanism by which disturbances to the labor market of one country are transmitted to that of the other in the short run and in the long run." PMID:12341287

  8. Children of Immigrants Longitudinal Study (CILS)

    OpenAIRE

    Rumbaut, RG; Portes, A.

    2006-01-01

    Children of Immigrants Longitudinal Study (CILS) was designed to study the adaptation process of the immigrant second generation which is defined broadly as United States-born children with at least one foreign-born parent or children born abroad but brought at an early age to the United States. The original survey was conducted with large samples of second-generation immigrant children attending the 8th and 9th grades in public and private schools in the metropolitan areas of Miami/Ft. Laude...

  9. Immigrant Self-Employment: Does Intermarriage Matter?

    OpenAIRE

    Georgarakos, Dimitris; Tatsiramos, Konstantinos

    2009-01-01

    This paper investigates the effect of a native spouse on the transitions into and out of entrepreneurship of male immigrants in the U.S. We find that those married to a native are less likely to start up a business compared to those married to an immigrant. This finding is robust when the endogeneity of being married to a native is taken into account. We also show that immigrants married to a native are significantly less likely to exit from entrepreneurship compared to their counterparts who...

  10. Determinants of Recent Immigrants' Location Choices

    DEFF Research Database (Denmark)

    Damm, Anna Piil

    2009-01-01

    rental, including social, housing and lack of institutions for qualifying educations which explain why recent immigrants are attracted to large cities. Finally, placed refugees tend to leave locations with relatively high regional unemployment and there is indirect evidence of welfare seeking.......This paper exploits a Danish spatial dispersal policy on refugees which can be regarded as a natural experiment to investigate the influence of regional factors on recent immigrants' location choices. The main push factors are lack of co-nationals and immigrants. Additional push factors are lack of...

  11. IMMIGRATION AND INTEGRATION POLICIES IN UK

    Directory of Open Access Journals (Sweden)

    Anca Voicu

    2009-06-01

    Full Text Available The number of immigrants received by the United Kingdom significantly increased during the past several years. Given the set of economic and social difficulties encountered, UK created for the first time a completely original system of Nationality Legislation and started to apply a severe policy of assimilation instead of integration. UK applied the Community Law concerning immigration, asylum and free movement of workers in its national interest, the whole European construction showing the “British specificities”. Even today, there are a lot of measures to be taken in order to come to a real integration policy of immigrants.

  12. Welfare work addressing immigrants and refugees

    DEFF Research Database (Denmark)

    Øland, Trine

    integrationist visions in their quest to protect immigrants’ and refugees’ fundamental wellbeing and status as human beings with equal rights, group life and history. These opposing elements generate ambiguity and contradiction within integrationist welfare work. The ambition of the presentation is to enquire......In this presentation I will discuss the ways in which welfare workers addressing immigrants and refugees (re)produce integrationist visions, symbolizing society as an integrated whole and immigrants/refugees as a distraction to that whole. Paradoxically, welfare workers also oppose these......, nurses and more) addressing immigrants and refugees and their families and descendants in the Danish welfare nation-state....

  13. Immigration-extinction dynamics of stochastic populations

    Science.gov (United States)

    Meerson, Baruch; Ovaskainen, Otso

    2013-07-01

    How high should be the rate of immigration into a stochastic population in order to significantly reduce the probability of observing the population become extinct? Is there any relation between the population size distributions with and without immigration? Under what conditions can one justify the simple patch occupancy models, which ignore the population distribution and its dynamics in a patch, and treat a patch simply as either occupied or empty? We answer these questions by exactly solving a simple stochastic model obtained by adding a steady immigration to a variant of the Verhulst model: a prototypical model of an isolated stochastic population.

  14. Limit theorems for fragmentation processes with immigration

    CERN Document Server

    Knobloch, Robert

    2012-01-01

    In this paper we extend two limit theorems which were recently obtained for fragmentation processes to such processes with immigration. More precisely, in the setting with immigration we consider a limit theorem for the process counted with a random characteristic as well as the asymptotic behaviour of an empirical measure associated with the stopping line corresponding to the first blocks, in their respective line of descent, that are smaller than a given size. In addition, we determine the asymptotic decay rate of the size of the largest block in a homogeneous fragmentation process with immigration. The techniques used to proves these results are based on submartingale arguments.

  15. Migration trends in Argentina: immigration and exile

    Directory of Open Access Journals (Sweden)

    Fernando Osvaldo ESTEBAN

    2010-10-01

    Full Text Available Through the development of a typology of migration flows, the paper reviews the most important trends in the history of Argentina: the massive European immigration, internal migrations, and immigration from neighbouring countries. The paper then discuss the current process of emigration from Argentina, and the return of old immigrants. The paper assess the economic factors involved through an analysis of unemployment, poverty and income distribution indicators in recent years. Finally, the paper examines the possibility of diminishing the recent emigration trend due to economic reasons.

  16. ADVANCES OF THE COMPREHENSIVE IMMIGRATION REFORM AGENDA IN AN AMERICAN SANCTUARY CITY FOR IMMIGRANTS

    OpenAIRE

    Paola Virginia Suárez Ávila

    2014-01-01

    The analysis of immigration policy on a local space is an important contribution by emphasis on the need for local governments in the United States to redefine its role in the state, which involves thinking about re-emerging activism of local governments thta has promoted the generation of new practices and immigration laws in local governments in the United States in the context of Immigration Reform debate.

  17. ADVANCES OF THE COMPREHENSIVE IMMIGRATION REFORM AGENDA IN AN AMERICAN SANCTUARY CITY FOR IMMIGRANTS

    Directory of Open Access Journals (Sweden)

    Paola Virginia Suárez Ávila

    2014-01-01

    Full Text Available The analysis of immigration policy on a local space is an important contribution by emphasis on the need for local governments in the United States to redefine its role in the state, which involves thinking about re-emerging activism of local governments thta has promoted the generation of new practices and immigration laws in local governments in the United States in the context of Immigration Reform debate.

  18. Prospects for Comprehensive Immigration Reform in 2012-2013: Accounting for Trends in Immigration Public Opinion

    OpenAIRE

    Abrejano, Marisa

    2013-01-01

    Marisa Abrajano examines whether landmark immigration events can leave a permanent mark on an individual's views towards immigration, and whether that impact varies across different racial and ethnic groups. Specifically, the author, examines the cohort of individuals who were in their formative years during the passage of major national immigration bills that were proposed or enacted from 1965-2010. Her findings indicate a clear and consistent relationship between these events and attitudes ...

  19. Trade Unions, immigration and immigrants in Europe revisited: Unions’ attitudes and actions under new conditions

    OpenAIRE

    Marino, S.; Penninx, R.; Roosblad, J.

    2015-01-01

    This paper revisits the comparative approach used by Penninx and Roosblad (Trade Unions, Immigration and Immigrants in Europe, 1960-1993. New York: Berghahn Books) to study trade unions’ attitudes and actions in relation to immigrant workers in seven Western European countries. It reassesses that approach and asks whether it remains valid, as economic, social, and political circumstances nowadays seem fundamentally different from those two to five decades ago. Each element of the original con...

  20. Branching processes with immigration and related topics

    OpenAIRE

    Li, Zenghu

    2006-01-01

    This is a survey on recent progresses in the study of branching processes with immigration, generalized Ornstein-Uhlenbeck processes and affine Markov processes. We mainly focus on the applications of skew convolution semigroups and the connections in those processes.